Neuronal migration disorders in microcephalic osteodysplastic primordial dwarfism type I/III.

PubMed

Juric-Sekhar, Gordana; Kapur, Raj P; Glass, Ian A; Murray, Mitzi L; Parnell, Shawn E; Hevner, Robert F

2011-04-01

Microcephalic osteodysplastic primordial dwarfism (MOPD) is a rare microlissencephaly syndrome, with at least two distinct phenotypic and genetic types. MOPD type II is caused by pericentrin mutations, while types I and III appear to represent a distinct entity (MOPD I/III) with variably penetrant phenotypes and unknown genetic basis. The neuropathology of MOPD I/III is little understood, especially in comparison to other forms of lissencephaly. Here, we report postmortem brain findings in an 11-month-old female infant with MOPD I/III. The cerebral cortex was diffusely pachygyric, with a right parietal porencephalic lesion. Histologically, the cortex was abnormally thick and disorganized. Distinct malformations were observed in different cerebral lobes, as characterized using layer-specific neuronal markers. Frontal cortex was severely disorganized and coated with extensive leptomeningeal glioneuronal heterotopia. Temporal cortex had a relatively normal 6-layered pattern, despite cortical thickening. Occipital cortex was variably affected. The corpus callosum was extremely hypoplastic. Brainstem and cerebellar malformations were also present, as well as old necrotic foci. Findings in this case suggest that the cortical malformation in MOPD I/III is distinct from other forms of pachygyria-lissencephaly.

Subcortical laminar heterotopia and lissencephaly in two families: a single X linked dominant gene.

PubMed Central

Pinard, J M; Motte, J; Chiron, C; Brian, R; Andermann, E; Dulac, O

1994-01-01

Neuronal migration disorders can now be recognised by MRI. This paper reports two families in which the mothers had subcortical laminar heterotopia and four of their children had either similar heterotopia (two girls) or severe pachygyria or lissencephaly (two boys). Laminar heterotopia was more evident on MRI T2 weighted images. The patients had mild to severe epilepsy and mental retardation depending on the extent of cortical abnormalities. In these families, subcortical laminar heterotopia, pachygyria, and lissencephaly seem to share the same X linked or autosomal dominant gene. No chromosomal abnormalities, especially of chromosome 17, could be identified. For appropriate genetic counselling of the family of a child with lissencephaly or subcortical laminar heterotopia, MRI should be performed in parents or siblings with mental retardation or epilepsy. Images PMID:8057113

Targeted deletion of RIC8A in mouse neural precursor cells interferes with the development of the brain, eyes, and muscles.

PubMed

Kask, Keiu; Tikker, Laura; Ruisu, Katrin; Lulla, Sirje; Oja, Eva-Maria; Meier, Riho; Raid, Raivo; Velling, Teet; Tõnissoo, Tambet; Pooga, Margus

2018-04-01

Autosomal recessive disorders such as Fukuyama congenital muscular dystrophy, Walker-Warburg syndrome, and the muscle-eye-brain disease are characterized by defects in the development of patient's brain, eyes, and skeletal muscles. These syndromes are accompanied by brain malformations like type II lissencephaly in the cerebral cortex with characteristic overmigrations of neurons through the breaches of the pial basement membrane. The signaling pathways activated by laminin receptors, dystroglycan and integrins, control the integrity of the basement membrane, and their malfunctioning may underlie the pathologies found in the rise of defects reminiscent of these syndromes. Similar defects in corticogenesis and neuromuscular disorders were found in mice when RIC8A was specifically removed from neural precursor cells. RIC8A regulates a subset of G-protein α subunits and in several model organisms, it has been reported to participate in the control of cell division, signaling, and migration. Here, we studied the role of RIC8A in the development of the brain, muscles, and eyes of the neural precursor-specific conditional Ric8a knockout mice. The absence of RIC8A severely affected the attachment and positioning of radial glial processes, Cajal-Retzius' cells, and the arachnoid trabeculae, and these mice displayed additional defects in the lens, skeletal muscles, and heart development. All the discovered defects might be linked to aberrancies in cell adhesion and migration, suggesting that RIC8A has a crucial role in the regulation of cell-extracellular matrix interactions and that its removal leads to the phenotype characteristic to type II lissencephaly-associated diseases. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 78: 374-390, 2018. © 2018 Wiley Periodicals, Inc.

Genetics Home Reference: isolated lissencephaly sequence

MedlinePlus

... This Page Dobyns WB. The clinical patterns and molecular genetics of lissencephaly and subcortical band heterotopia. Epilepsia. 2010 ... Feb 23. Review. Citation on PubMed Liu JS. Molecular genetics of neuronal migration disorders. Curr Neurol Neurosci Rep. ...

Genetics Home Reference: lissencephaly with cerebellar hypoplasia

MedlinePlus

... on PubMed or Free article on PubMed Central Ross ME, Swanson K, Dobyns WB. Lissencephaly with cerebellar ... AA, Abdel-Salam G, Koeller HB, Ilkin Y, Ross ME, Dobyns WB, Gleeson JG. Identification of a ...

Magnetic Resonance Imaging of Malformations of Midbrain-Hindbrain.

PubMed

Abdel Razek, Ahmed Abdel Khalek; Castillo, Mauricio

2016-01-01

We aim to review the magnetic resonance imaging appearance of malformations of midbrain and hindbrain. These can be classified as predominantly cerebellar malformations, combined cerebellar and brain stem malformations, and predominantly brain stem malformations. The diagnostic criteria for the majority of these morphological malformations are based on neuroimaging findings. The predominantly cerebellar malformations include predominantly vermian hypoplasia seen in Dandy-Walker malformation and rhombencephalosynapsis, global cerebellar hypoplasia reported in lissencephaly and microlissencephaly, and unilateral cerebellar hypoplasia seen in PHACES, vanishing cerebellum, and cerebellar cleft. Cerebellar dysplasias are seen in Chudley-McCullough syndrome, associated with LAMA1 mutations and GPR56 mutations; Lhermitte-Duclos disease; and focal cerebellar dysplasias. Cerebellar hyperplasias are seen in megalencephaly-related syndromes and hemimegalencephaly with ipsilateral cerebellomegaly. Cerebellar and brain stem malformations include tubulinopathies, Joubert syndrome, cobblestone malformations, pontocerebellar hypoplasias, and congenital disorders of glycosylation type Ia. Predominantly brain stem malformations include congenital innervation dysgenesis syndrome, pontine tegmental cap dysplasia, diencephalic-mesencephalic junction dysplasia, disconnection syndrome, and pontine clefts.

Neuronal migration disorders in microcephalic osteodysplastic primordial dwarfism type I/III

PubMed Central

Juric-Sekhar, Gordana; Kapur, Raj P.; Glass, Ian A.; Murray, Mitzi L.; Parnell, Shawn E.

2011-01-01

Microcephalic osteodysplastic primordial dwarfism (MOPD) is a rare microlissencephaly syndrome, with at least two distinct phenotypic and genetic types. MOPD type II is caused by pericentrin mutations, while types I and III appear to represent a distinct entity (MOPD I/III) with variably penetrant phenotypes and unknown genetic basis. The neuropathology of MOPD I/III is little understood, especially in comparison to other forms of lissencephaly. Here, we report postmortem brain findings in an 11-month-old female infant with MOPD I/III. The cerebral cortex was diffusely pachygyric, with a right parietal porencephalic lesion. Histologically, the cortex was abnormally thick and disorganized. Distinct malformations were observed in different cerebral lobes, as characterized using layer-specific neuronal markers. Frontal cortex was severely disorganized and coated with extensive leptomeningeal glioneuronal heterotopia. Temporal cortex had a relatively normal 6-layered pattern, despite cortical thickening. Occipital cortex was variably affected. The corpus callosum was extremely hypoplastic. Brainstem and cerebellar malformations were also present, as well as old necrotic foci. Findings in this case suggest that the cortical malformation in MOPD I/III is distinct from other forms of pachygyria–lissencephaly. PMID:20857301

LIS1-associated classic lissencephaly: A retrospective, multicenter survey of the epileptogenic phenotype and response to antiepileptic drugs.

PubMed

Herbst, Saskia M; Proepper, Christiane R; Geis, Tobias; Borggraefe, Ingo; Hahn, Andreas; Debus, Otfried; Haeussler, Martin; von Gersdorff, Gero; Kurlemann, Gerhard; Ensslen, Matthias; Beaud, Nathalie; Budde, Joerg; Gilbert, Michael; Heiming, Ralf; Morgner, Rita; Philippi, Heike; Ross, Sophia; Strobl-Wildemann, Gertrud; Muelleder, Kerstin; Vosschulte, Paul; Morris-Rosendahl, Deborah J; Schuierer, Gerhard; Hehr, Ute

2016-04-01

Patients with LIS1-associated classic lissencephaly typically present with severe psychomotor retardation and drug-resistant epilepsy within the first year. To analyze the epileptogenic phenotype and response to antiepileptic therapy in LIS1-associated classic lissencephaly. Retrospective evaluation of 22 patients (8 months-24 years) with genetically and radiologically confirmed LIS1-associated classic lissencephaly in 16 study centers. All patients in our cohort developed drug-resistant epilepsy. In 82% onset of seizures was noted within the first six months of life, most frequently with infantile spasms. Later in infancy the epileptogentic phenotype became more variable and included different forms of focal seizures as well generalized as tonic-clonic seizures, with generalized tonic-clonic seizures being the predominant type. Lamotrigine and valproate were rated most successful with good or partial response rates in 88-100% of the patients. Both were evaluated significantly better than levetiracetam (p<0.05) and sulthiame (p<0.01) in the neuropediatric assessment and better than levetiracetam, sulthiame (p<0.05) and topiramate (p<0.01) in the family survey. Phenobarbital and vigabatrin achieved good or partial response in 62-83% of the patients. Our findings suggest that patients with LIS1-associated lissencephaly might benefit most from lamotrigine, valproate, vigabatrin or phenobarbital. Copyright © 2015 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

Emanuel Miller Lecture: Confusions and Controversies about Asperger Syndrome

ERIC Educational Resources Information Center

Frith, Uta

2004-01-01

Background: Hans Asperger drew attention to individuals who show the core symptoms of autism in the presence of high verbal intelligence. Methods: A review of the literature explores current issues concerning the diagnosis and nature of Asperger syndrome. Results: The behavioural and neurophysiological evidence to date suggests that Asperger…

Bickerstaff's encephalitis

PubMed Central

Horton, Emma; Krishnamoorthy, Sanjay; Reynolds, Lucy

2014-01-01

Bickerstaff's brainstem encephalitis is a rare syndrome defined by the triad of ophthalmoplegia, ataxia and decreased consciousness. It is considered to be a variant of Miller Fisher syndrome and Guillain-Barré syndrome but is differentiated from the two by the presence of central nervous system involvement, commonly in the form of impaired consciousness. We present an unusual case of Bickerstaff's encephalitis, where the patient presented with pseudobulbar affect. PMID:25080547

A Competency-Based Medical Student Curriculum Targeting Key Geriatric Syndromes

ERIC Educational Resources Information Center

van Zuilen, Maria H.; Rodriguez, Osvaldo; Mintzer, Michael J.; Paniagua, Miguel A.; Milanez, Marcos N.; Ruiz, Jorge G.; Kaiser, Robert M.; Roos, Bernard A.

2008-01-01

The University of Miami Miller School of Medicine (UMMSM) has developed and implemented a competency-based undergraduate medical education (UME) curriculum that targets 61 learning objectives for three geriattic syndromes: dementia, falls, and delirium. This curriculum redesign changed the educational focus from what is taught to what is learned.…

Malformations of cortical development: clinical spectrum in a series of 101 patients and review of the literature (Part I).

PubMed

Güngör, Serdal; Yalnizoğlu, Dilek; Turanli, Güzide; Saatçi, Işil; Erdoğan-Bakar, Emel; Topçu, Meral

2007-01-01

Patients with malformations of cortical development (MCD) present with a wide spectrum of clinical manifestations ranging from asymptomatic cases to those with epilepsy and neurodevelopmental problems. Thorough clinical delineation of patients with MCD may provide clues for future phenotype-genotype correlation studies. We studied clinical features of patients with MCD, including developmental risk factors and family history. We evaluated 10 patients with MCD at Hacettepe University Children's Hospital, Department of Pediatric Neurology. All patients underwent neurological evaluation with detailed medical and family history, and neuropsychological evaluation. Routine EEG and MRI were obtained. The patients were between 1 month and 19 years of age (mean: 6.1 +/- 4.4 years). Fifty-four patients were diagnosed with polymicrogyria (PMG), 23 patients with lissencephaly, 12 patients with schizencephaly, and 12 patients with heterotopia. Parents were relatives in 31.7% of the cases; consanguinity was most common in patients with lissencephaly and other MCDs with diffuse/bilateral involvement. Initial clinical presentation was seizures in 61.4% of the cases, developmental delays in 12.9%, and microcephaly in 9.9%. Neurological evaluation revealed most severe abnormalities in patients with lissencephaly, and relatively better outcome in patients with heterotopias. Cognitive functions were better in patients with heterotopias compared to other groups. Overall, 71.3% of patients ha epilepsy. In conclusion, initial presentation and clinical course of patients with MCD are variable and seem to be correlated with the extent of cortical involvement. Epilepsy and mental retardation are the most common problems. The most severe clinical outcome was seen in patients with lissencephaly.

Miller Fisher Syndrome

MedlinePlus

... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...

Baraitser and Winter syndrome with growth hormone deficiency.

PubMed

Chentli, Farida; Zellagui, Hadjer

2014-01-01

Baraitser-Winter syndrome (BWS), first reported in 1988, is apparently due to genetic abnormalities that are still not well-defined, although many gene abnormalities are already discovered and de novo missense changes in the cytoplasmic actin-encoding genes (called ACTB and ACTG1) have been recently discovered. The syndrome combines facial and cerebral malformations. Facial malformations totally or partially present in the same patient are: Iris coloboma, bilateral ptosis, hypertelorism, broad nasal bridge, and prominent epicanthic folds. The various brain malformations are probably responsible for growth and mental retardation. To the best of our knowledge, the syndrome is very rare as few cases have been reported so far. Our aim was to describe a child with a phenotype that looks like BWS with proved partial growth hormone (GH) deficiency which was not reported before. A girl aged 7-year-old of consanguineous parents was referred for short stature and mental retardation. Clinical examination showed dwarfism and a delay in her mental development. Other clinical features included: Strabismus, epicanthic folds, broad nasal bridge, and brain anomalies such as lissencephaly, bilateral hygroma, and cerebral atrophy. Hormonal assessment showed partial GH deficiency without other endocrine disorders. Our case looks exactly like BWS. However, apart from facial and cerebral abnormalities, there is a partial GH deficiency which can explain the harmonious short stature. This case seems worth to be reported as it adds GH deficiency to the very rare syndrome.

Miller Fisher Syndrome

MedlinePlus

... weeks earlier. Slurred speech, difficulty swallowing and abnormal facial expression with inability to smile or whistle may also occur. Examination shows poor balance and coordination of the hands as well as loss of ... Facial weakness, enlarged or dilated pupils and a decreased ...

Genetics Home Reference: Miller syndrome

MedlinePlus

... a limb bud, which grows outward. Many different proteins are involved in the normal shaping (patterning) of each limb. Once the overall pattern of a ... for This Page Biesecker LG. Exome sequencing makes medical genomics a reality. Nat Genet. 2010 ...

Recurrent Guillain-Barré syndrome, Miller Fisher syndrome and Bickerstaff brainstem encephalitis.

PubMed

Ishii, Junko; Yuki, Nobuhiro; Kawamoto, Michi; Yoshimura, Hajime; Kusunoki, Susumu; Kohara, Nobuo

2016-05-15

Guillain-Barré syndrome (GBS), Miller Fisher syndrome (MFS), and Bickerstaff brainstem encephalitis (BBE) are usually monophasic, but some patients experience recurrences after long asymptomatic intervals. We aimed to investigate clinical features of recurrent GBS, MFS, and BBE at a single hospital. Records from 97 consecutive patients with GBS, MFS or BBE who were admitted to a tertiary hospital between 2001 and 2013 were reviewed. Clinical and laboratory features of patients with recurrent GBS, MFS, or BBE were investigated. Patients included 55 (32 males) with GBS, 34 (22 males) with MFS, and 8 (6 males) with BBE. Recurrent cases occurred in 2 (4%) of the 55 patients with GBS, 4 (12%) of the 34 patients with MFS, and 2 (25%) of the 8 patients with BBE. Patients with recurrent MFS had a tendency to be younger at the first episode than patients with non-recurrent MFS (median, 22 versus 37years old). Symptoms and signs were less severe during relapses than during the initial episode in recurrent patients. Recurrences occurred more frequently in patients with MFS or BBE compared with those with GBS. Patients with recurrent MFS might be younger than those with non-recurrent MFS. Copyright © 2016 Elsevier B.V. All rights reserved.

The Drosophila cell adhesion molecule Neuroglian regulates Lissencephaly-1 localisation in circulating immunosurveillance cells.

PubMed

Williams, Michael J

2009-03-25

When the parasitoid wasp Leptopilina boulardi lays its eggs in Drosophila larvae phagocytic cells called plasmatocytes and specialized cells known as lamellocytes encapsulate the egg. This requires these circulating immunosurveillance cells (haemocytes) to change from a non-adhesive to an adhesive state enabling them to bind to the invader. Interestingly, attachment of leukocytes, platelets, and insect haemocytes requires the same adhesion complexes as epithelial and neuronal cells. Here evidence is presented showing that the Drosophila L1-type cell adhesion molecule Neuroglian (Nrg) is required for haemocytes to encapsulate L. boulardi wasp eggs. The amino acid sequence FIGQY containing a conserved phosphorylated tyrosine is found in the intracellular domain of all L1-type cell adhesion molecules. This conserved tyrosine is phosphorylated at the cell periphery of plasmatocytes and lamellocytes prior to parasitisation, but dephosphorylated after immune activation. Intriguingly, another pool of Nrg located near the nucleus of plasmatocytes remains phosphorylated after parasitisation. In mammalian neuronal cells phosphorylated neurofascin, another L1-type cell adhesion molecule interacts with a nucleokinesis complex containing the microtubule binding protein lissencephaly-1 (Lis1) 1. Interestingly in plasmatocytes from Nrg mutants the nucleokinesis regulating protein Lissencephaly-1 (Lis1) fails to localise properly around the nucleus and is instead found diffuse throughout the cytoplasm and at unidentified perinuclear structures. After attaching to the wasp egg control plasmatocytes extend filopodia laterally from their cell periphery; as well as extending lateral filopodia plasmatocytes from Nrg mutants also extend many filopodia from their apical surface. The Drosophila cellular adhesion molecule Neuroglian is expressed in haemocytes and its activity is required for the encapsulation of L. boularli eggs. At the cell periphery of haemocytes Neuroglian may be involved in cell-cell interactions, while at the cell centre Neuroglian regulates the localisation of the nucleokinesis complex protein lissencephaly-1.

The Drosophila cell adhesion molecule Neuroglian regulates Lissencephaly-1 localisation in circulating immunosurveillance cells

PubMed Central

Williams, Michael J

2009-01-01

Background When the parasitoid wasp Leptopilina boulardi lays its eggs in Drosophila larvae phagocytic cells called plasmatocytes and specialized cells known as lamellocytes encapsulate the egg. This requires these circulating immunosurveillance cells (haemocytes) to change from a non-adhesive to an adhesive state enabling them to bind to the invader. Interestingly, attachment of leukocytes, platelets, and insect haemocytes requires the same adhesion complexes as epithelial and neuronal cells. Results Here evidence is presented showing that the Drosophila L1-type cell adhesion molecule Neuroglian (Nrg) is required for haemocytes to encapsulate L. boulardi wasp eggs. The amino acid sequence FIGQY containing a conserved phosphorylated tyrosine is found in the intracellular domain of all L1-type cell adhesion molecules. This conserved tyrosine is phosphorylated at the cell periphery of plasmatocytes and lamellocytes prior to parasitisation, but dephosphorylated after immune activation. Intriguingly, another pool of Nrg located near the nucleus of plasmatocytes remains phosphorylated after parasitisation. In mammalian neuronal cells phosphorylated neurofascin, another L1-type cell adhesion molecule interacts with a nucleokinesis complex containing the microtubule binding protein lissencephaly-1 (Lis1) [1]. Interestingly in plasmatocytes from Nrg mutants the nucleokinesis regulating protein Lissencephaly-1 (Lis1) fails to localise properly around the nucleus and is instead found diffuse throughout the cytoplasm and at unidentified perinuclear structures. After attaching to the wasp egg control plasmatocytes extend filopodia laterally from their cell periphery; as well as extending lateral filopodia plasmatocytes from Nrg mutants also extend many filopodia from their apical surface. Conclusion The Drosophila cellular adhesion molecule Neuroglian is expressed in haemocytes and its activity is required for the encapsulation of L. boularli eggs. At the cell periphery of haemocytes Neuroglian may be involved in cell-cell interactions, while at the cell centre Neuroglian regulates the localisation of the nucleokinesis complex protein lissencephaly-1. PMID:19320973

Exclusion of TCOF1 mutations in a case of bilateral Goldenhar syndrome and one familial case of microtia with meatal atresia.

PubMed

Thiel, Christian T; Rosanowski, Frank; Kohlhase, Jürgen; Reis, André; Rauch, Anita

2005-04-01

A number of different disorders involving first and second branchial arch anomalies have been described as distinct entities, including Treacher-Collins-Franceschetti syndrome, Goldenhar syndrome, Nager syndrome and Miller syndrome. The significant phenotypic overlap between these disorders raises the issue of a common developmental origin. After the identification of mutations in TCOF1 as a general cause of the Treacher-Collins-Franceschetti syndrome, TCOF1 mutations were excluded in patients with unilateral signs of the Goldenhar syndrome spectrum. We also present two rare cases of bilateral Goldenhar syndrome and familial microtia with meatal atresia, respectively, in whom we also excluded TCOF1 mutations. Thus, genetic heterogeneity in different disorders of the first and second branchial arch development is supported.

Ocular abnormalities in congenital Zika syndrome: a case report, and review of the literature.

PubMed

Guevara, Jade Gieseke; Agarwal-Sinha, Swati

2018-06-09

As the number of children with Zika virus-related complications grows, the long-term developmental trajectory and its effects on families are unknown. We present the first known case of congenital Zika syndrome seen at our institution with significant fundus findings. A 3-day-old Hispanic baby girl presented with severe microcephaly of 24 cm and temperature instability at birth. Her mother had traveled to Honduras early in pregnancy and testing of amniotic fluid was positive for Zika virus via polymerase chain reaction. A dilated fundus examination was significant for bilateral severe colobomatous chorioretinal atrophy of the macula and pigmentary changes. Neonatal magnetic resonance imaging revealed diffuse lissencephaly with decreased brain volume, atrophic corpus callosum and brainstem, periventricular calcifications, and ventriculomegaly of the lateral ventricles. Our patient, who presented with the first known case of congenital Zika syndrome in Northern Florida, demonstrated profound bilateral colobomatous chorioretinal atrophy of the macula. The ophthalmologic findings along with severe microcephaly emphasize the neurotropism of the Zika virus, and ultimately are indicative of poor developmental and visual prognosis for affected infants. With the increased prevalence of Zika virus, ophthalmologists should be aware of the associated findings and the importance of an eye-screening examination with a dilated fundus examination within 1 month of life of infants in which congenital Zika syndrome is suspected. A multidisciplinary care approach is essential for the care of affected infants and their families.

Neuroimaging findings of congenital Zika virus infection: a pictorial essay.

PubMed

Zare Mehrjardi, Mohammad; Poretti, Andrea; Huisman, Thierry A G M; Werner, Heron; Keshavarz, Elham; Araujo Júnior, Edward

2017-03-01

Zika virus (ZIKV) is a mosquito-borne arbovirus from the Flaviviridae family. It had caused several epidemics since its discovery in 1947, but there was no significant attention to this virus until the recent outbreak in Brazil in 2015. The main concern is the causal relationship between prenatal ZIKV infection and congenital microcephaly, which has been confirmed recently. Moreover, ZIKV may cause other central nervous system abnormalities such as brain parenchymal atrophy with secondary ventriculomegaly, intracranial calcification, malformations of cortical development (such as polymicrogyria, and lissencephaly-pachygyria), agenesis/hypoplasia of the corpus callosum, cerebellar and brainstem hypoplasia, sensorineural hearing-loss, and ocular abnormalities as well as arthrogryposis in the infected fetuses. Postnatal (acquired) ZIKV infection usually has an asymptomatic or mildly symptomatic course, while prenatal (congenital) ZIKV infection has a more severe course and may cause severe brain anomalies that are described as congenital Zika syndrome. In this pictorial essay, we aim to illustrate the prenatal and postnatal neuroimaging findings that may be seen in fetuses and neonates with congenital Zika syndrome, and will discuss possible radiological differential diagnoses. A detailed knowledge of these findings is paramount for an early correct diagnosis, prognosis determination, and counseling of the affected children and families.

Lissencephaly

MedlinePlus

... level. Others may have near-normal development and intelligence. Because of this range, it is important to ... level. Others may have near-normal development and intelligence. Because of this range, it is important to ...

Emanuel Miller Lecture: Early Onset Depressions--Meanings, Mechanisms and Processes

ERIC Educational Resources Information Center

Goodyer, Ian M.

2008-01-01

Background: Depressive syndromes in children and adolescents constitute a serious group of mental disorders with considerable risk for recurrence. A more precise understanding of aetiology is necessary to improve treatment and management. Methods: Three neuroactive agents are purported to be involved in the aetiology of these disorders: serotonin,…

Tumor Microenvironment Inflammation and Obesity in Advanced Prostate Cancer

DTIC Science & Technology

2015-09-30

predicts metabolic syndrome inde- pendently of individual-level SES [47]. A number of limitations affect the inferences of this study. We were unable to...disparities? Biol Res Nurs 7(1):7–15 45. Clegg L, Reichman M, Miller B, Hankey B, Singh G, Lin Y, Goodman M, Lynch C, Schwartz S, Chen V et al (2009) Impact...incidence of metabolic syndrome : a prospective cohort study. BMC public health 13:681 48. Boardman J (2004) Stress and physical health: the role of

Serum antibodies against gangliosides and Campylobacter jejuni lipopolysaccharides in Miller Fisher syndrome.

PubMed Central

Neisser, A; Bernheimer, H; Berger, T; Moran, A P; Schwerer, B

1997-01-01

Seven patients with Miller Fisher syndrome (MFS), six in the acute phase and one in the recovery phase, were investigated for serum antibodies against gangliosides and purified lipopolysaccharides (LPS) from different strains of Campylobacter jejuni, including the MFS-associated serotypes O:2 and O:23. Immunoglobulin G antibodies against gangliosides GT1a and GQ1b were found in five of six patients in the acute phase of disease. Three of these patients also displayed antibodies to ganglioside GD2, a finding not previously reported for MFS. All anti-GT1a- and anti-GQ1b-seropositive patients showed antibody binding to C. jejuni LPS, predominantly to O:2 and O:23 LPS. Antibody cross-reactivity between gangliosides GT1a and GQ1b and O:2 and O:23 LPS was demonstrated by adsorption studies. This cross-reactivity between gangliosides and C.jejuni LPS, which is obviously due to oligosaccharide homologies, may be an important pathogenetic factor in the development of MFS after C. jejuni infection. PMID:9317004

B3GALNT2-Related Dystroglycanopathy: Expansion of the Phenotype with Novel Mutation Associated with Muscle-Eye-Brain Disease, Walker-Warburg Syndrome, Epileptic Encephalopathy-West Syndrome, and Sensorineural Hearing Loss.

PubMed

Al Dhaibani, Muna A; El-Hattab, Ayman W; Ismayl, Omar; Suleiman, Jehan

2018-05-23

Mutations in B3GALNT2 , encoding a glycosyltransferase enzyme involved in α-dystroglycan glycosylation, have been recently associated with dystroglycanopathy, a well-recognized subtype of congenital muscular dystrophy (CMD). Only a few cases have been reported with B3GALNT2 -related dystroglycanopathy with variable severity ranging from mild CMD to severe muscle-eye-brain disease. Here, we describe a child with a novel homozygous nonsense mutation in B3GALNT2 . The affected child has severe neurological disease since birth, including muscle disease manifested as hypotonia, muscle weakness, and wasting with elevated creatine kinase, eye disease including microphthalmia and blindness, brain disease with extensive brain malformations including massive hydrocephalus, diffuse cobblestone-lissencephaly, deformed craniocervical junction, and pontocerebellar hypoplasia. The clinical and radiologic findings are compatible with a diagnosis of severe muscle-eye-brain disease and more specifically Walker-Warburg syndrome. A more distinct aspect of the clinical phenotype in this child is the presence of refractory epilepsy in the form of epileptic spasms, epileptic encephalopathy, and West syndrome, as well as sensorineural hearing loss. These findings could expand the phenotype of B3GALNT2 -related dystroglycanopathy. In this report, we also provide a detailed review of previously reported cases with B3GALNT2 -related dystroglycanopathy and compare them to our reported child. In addition, we study the genotype-phenotype correlation in these cases. Georg Thieme Verlag KG Stuttgart · New York.

Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans

PubMed Central

Keays, David A.; Tian, Guoling; Poirier, Karine; Huang, Guo-Jen; Siebold, Christian; Cleak, James; Oliver, Peter L.; Fray, Martin; Harvey, Robert J.; Molnár, Zoltán; Piñon, Maria C.; Dear, Neil; Valdar, William; Brown, Steve D.M.; Davies, Kay E.; Rawlins, J. Nicholas P.; Cowan, Nicholas J.; Nolan, Patrick; Chelly, Jamel; Flint, Jonathan

2007-01-01

Summary The development of the mammalian brain is dependent on extensive neuronal migration. Mutations in mice and humans that affect neuronal migration result in abnormal lamination of brain structures with associated behavioral deficits. Here, we report the identification of a hyperactive N-ethyl-N-nitrosourea (ENU)-induced mouse mutant with abnormalities in the laminar architecture of the hippocampus and cortex, accompanied by impaired neuronal migration. We show that the causative mutation lies in the guanosine triphosphate (GTP) binding pocket of α-1 tubulin (Tuba1) and affects tubulin heterodimer formation. Phenotypic similarity with existing mouse models of lissencephaly led us to screen a cohort of patients with developmental brain anomalies. We identified two patients with de novo mutations in TUBA3, the human homolog of Tuba1. This study demonstrates the utility of ENU mutagenesis in the mouse as a means to discover the basis of human neurodevelopmental disorders. PMID:17218254

A case of cecal volvulus presenting with chronic constipation in lissencephaly.

PubMed

Lee, Eun-Kyung; Kim, Ji Eun; Lee, Yun-Young; Kim, Saeyoon; Choi, Kwang Hea

2013-06-01

Cecal volvulus is uncommon in pediatric patients and there are few reports of cecal volvulus with cerebral palsy. Here, we report the case of a 19-year-old male patient who presented with abdominal distension, a history of cerebral palsy, refractory epilepsy due to lissencephaly, and chronic constipation. An abdominal x-ray and computed tomography without contrast enhancement showed fixed dilated bowel intensity in the right lower abdomen. Despite decompression with gastric and rectal tube insertion, symptoms did not improve. The patient underwent an exploratory laparotomy that revealed cecal volvulus. Cecal volvulus usually occurs following intestinal malrotation or previous surgery. In this patient, however, intestinal distension accompanying mental disability and chronic constipation resulted in the development of cecal volvulus. We suggest that cecal and proximal large bowel volvulus should be considered in patients presenting with progressive abdominal distension combined with a history of neuro-developmental delay and constipation.

A Case of Cecal Volvulus Presenting with Chronic Constipation in Lissencephaly

PubMed Central

Lee, Eun-Kyung; Kim, Ji Eun; Lee, Yun-young; Kim, Saeyoon

2013-01-01

Cecal volvulus is uncommon in pediatric patients and there are few reports of cecal volvulus with cerebral palsy. Here, we report the case of a 19-year-old male patient who presented with abdominal distension, a history of cerebral palsy, refractory epilepsy due to lissencephaly, and chronic constipation. An abdominal x-ray and computed tomography without contrast enhancement showed fixed dilated bowel intensity in the right lower abdomen. Despite decompression with gastric and rectal tube insertion, symptoms did not improve. The patient underwent an exploratory laparotomy that revealed cecal volvulus. Cecal volvulus usually occurs following intestinal malrotation or previous surgery. In this patient, however, intestinal distension accompanying mental disability and chronic constipation resulted in the development of cecal volvulus. We suggest that cecal and proximal large bowel volvulus should be considered in patients presenting with progressive abdominal distension combined with a history of neuro-developmental delay and constipation. PMID:24010118

A Novel Missense Mutation of Doublecortin: Mutation Analysis of Korean Patients with Subcortical Band Heterotopia

PubMed Central

Kim, Myeong-Kyu; Park, Man-Seok; Kim, Byeong-Chae; Cho, Ki-Hyun; Kim, Young-Seon; Kim, Jin-Hee; Heo, Tag; Kim, Eun-Young

2005-01-01

The neuronal migration disorders, X-linked lissencephaly syndrome (XLIS) and subcortical band heterotopia (SBH), also called "double cortex", have been linked to missense, nonsense, aberrant splicing, deletion, and insertion mutations in doublecortin (DCX) in families and sporadic cases. Most DCX mutations identified to date are located in two evolutionarily conserved domains. We performed mutation analysis of DCX in two Korean patients with SBH. The SBH patients had mild to moderate developmental delays, drug-resistant generalized seizures, and diffuse thick SBH upon brain MRI. Sequence analysis of the DCX coding region in Patient 1 revealed a c.386 C>T change in exon 3. The sequence variation results in a serine to leucine amino acid change at position 129 (S129L), which has not been found in other family members of Patient 1 or in a large panel of 120 control X-chromosomes. We report here a novel c.386 C>T mutation of DCX that is responsible for SBH. PMID:16100463

Bickerstaff's encephalitis and Miller Fisher syndrome associated with voltage-gated potassium channel and novel anti-neuronal antibodies.

PubMed

Tüzün, E; Kürtüncü, M; Lang, B; Içöz, S; Akman-Demir, G; Eraksoy, M; Vincent, A

2010-10-01

GQ1b antibody (GQ1b-Ab) is detected in approximately two-thirds of sera of patients with Bickerstaffs encephalitis (BE). Whilst some of the remaining patients have antibodies to other gangliosides, many patients with BE are reported to be seronegative. Voltage-gated potassium channel antibody (VGKC-Ab) at high titer was detected during the diagnostic work-up of one patient with BE. Sera of an additional patient with BE and nine patients with Miller Fisher syndrome (MF) (all GQ1b-Ab positive) were investigated for VGKC-Ab and other anti-neuronal antibodies by radioimmunoprecipitation using 125I-dendrotoxin-VGKC and immunohistochemistry, respectively. Two patients with MF exhibited moderate titer VGKC-Abs. Regardless of positivity for VGKC or GQ1b antibodies, serum IgG of all patients with BE and MF reacted with the molecular layer and Purkinje cells of the cerebellum in a distinctive pattern. Voltage-gated potassium channel antibodies might be involved in some cases of BE or MF. The common staining pattern despite different antibody results suggests that there might be other, as yet unidentified, antibodies associated with BE and MF.

Electrophysiological evidence of cerebellar fiber system involvement in the Miller Fisher syndrome.

PubMed

Lo, Y L; Fook-Chong, S; Chan, L L; Ong, W Y; Ratnagopal, P

2010-01-15

In the Miller Fisher syndrome (MFS), ataxia may be due involvement of Ia afferents and the cerebellum. Transcranial magnetic stimulation (TMS) over the cerebellum is known to interfere transiently with normal function. In this study, we utilized a previously described TMS protocol over the cerebellum in combination with ballistic movements to investigate cerebellar dysfunction in MFS patients. The agonist (biceps) reaction time in MFS patients during a motor cancellation task was not significantly reduced during the initial TMS study. However, during the repeat TMS study, significant reduction was seen for all patients, in tandem with clinical recovery. There was significant correlation between anti-GQ1b IgG titers and change in agonist reaction time between the initial and repeat TMS studies. TMS likely affected horizontally orientated parallel fibers in the cerebellar molecular layer. During disease onset, antibody binding may have interfered with facilitation of reaction time during motor cancellation tasks seen in normal subjects. Normalization of reaction time facilitation corresponded to resolution of antibody-mediated interference in the molecular layer. Our study has provided evidence suggesting parallel fiber involvement in MFS, and suggested a role of anti-GQ1b IgG antibody in these changes.

A novel mutation in the aristaless domain of the ARX gene leads to Ohtahara syndrome, global developmental delay, and ambiguous genitalia in males and neuropsychiatric disorders in females.

PubMed

Ekşioğlu, Yaman Z; Pong, Amanda W; Takeoka, Masanori

2011-05-01

ARX, the aristaless-related homeobox gene, is implicated in cerebral, testicular, and pancreatic development. ARX mutations are associated with various forms of epilepsy, developmental delay, and ambiguous genitalia in humans. A mouse model that recapitulates X-linked lissencephaly with ambiguous genitalia (XLAG) is far from elucidating the substrate for phenotypes that different ARX mutations cause. Moreover, despite phenotypic pleomorphism associated with X-linked dominant ARX mutations, heterozygous female carriers have not been thoroughly studied. Reviewing records of patients with ARX mutations, infantile epilepsies, and psychomotor retardation, we analyzed a family harboring a novel ARX mutation with different phenotypes in males and females, including Ohtahara syndrome. Children's Hospital Boston patient records were retrospectively screened for patients with infantile epileptic encephalopathies who underwent ARX sequencing based on clinical suspicion. Identified families were analyzed for genetic and neuropsychiatric phenomena. The proband was a male with Ohtahara syndrome, ambiguous genitalia, psychomotor delay, and central nervous system dysgenesis due to a novel ARX mutation in exon 5, causing a frameshift in the aristaless domain. Heterozygous females demonstrated neurocognitive/psychiatric phenomena including learning difficulties, anxiety, depression, and schizophrenia. This is the first reported case of Ohtahara syndrome with abnormal genital and psychomotor development in the setting of this novel ARX mutation in exon 5. Based on the unique phenotype of the proband and on the presence of heterozygous females with neurocognitive/psychiatric ailments, this study describes the potential roles for ARX mutations in epilepsy and neuropsychiatric disease, underscoring the importance of ARX in interneuron development, cerebral electrical activity, cognition, and behavior. Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.

Malformations of cortical development and epilepsy: evaluation of 101 cases (part II).

PubMed

Güngör, Serdal; Yalnizoğlu, Dilek; Turanli, Güzide; Saatçi, Işil; Erdoğan-Bakar, Emel; Topçu, Meral

2007-01-01

Malformations of cortical development (MCD) form a spectrum of lesions produced by insult to the developing neocortex. Clinical presentation and electrophysiologic findings of MCD are variable and depend on the affected cortical area. We evaluated epilepsy, EEG, and response to antiepileptic treatment in patients with MCD with respect to the neuroimaging findings. We studied 101 patients, ranging between 1 month and 19 years of age. Fifty-four patients were diagnosed with polymicrogyria (PMG), 23 patients with lissencephaly, 12 patients with schizencephaly, and 12 patients with heterotopia. With regards to epilepsy and seizure type, 72/101 (71.3%) patients had epilepsy, and 62/101 (61.4%) patients presented with seizures. Overall, 32.7% of patients had generalized seizures, and 25.7% had complex partial seizures. Mean age at the onset of seizures was 2.7 +/- 3.4 years. The onset of epilepsy tended to be younger in patients with lissencephaly and older in patients with heterotopias. Of the cases, 79.2% had abnormal EEG (56.3% with epileptiform abnormality, 22.9% with non-epileptiform abnormality). EEG was abnormal in 44.9% (13/29) of the cases without epilepsy. EEG showed bilateral synchronous and diffuse epileptiform discharges in 90% of patients with lissencephaly. Patients with schizencephaly had mostly focal epileptiform discharges. Heterotopia cases had a high rate of EEG abnormalities (72.7%). Patients with PMG had epileptiform abnormality in 59.5% of the cases. Patients with heterotopias and PMG achieved better seizure control in comparison with the other groups. In conclusion, epilepsy is the most common problem in MCD. Epilepsy and EEG findings of patients with MCD are variable and seem to be correlated with the extent of cortical involvement.

Guillain-Barré Syndrome.

PubMed

Wijdicks, Eelco F M; Klein, Christopher J

2017-03-01

Guillain-Barré syndrome is an acute inflammatory immune-mediated polyradiculoneuropathy presenting typically with tingling, progressive weakness, and pain. Variants and formes frustes may complicate recognition. The best known variant is the sensory ataxic form of Miller Fisher syndrome, which also affects the oculomotor nerves and the brain stem. Divergent pathologic mechanisms lead to demyelinating, axonal, or mixed demyelinating-axonal damage. In the demyelinating form, yet to be identified antigens are inferred by complement activation, myelin destruction, and macrophage-activated cleanup. In the axonal and Miller Fisher variants, gangliosides (GM1, GD1a, GQ1b) are targeted by immunoglobulins and share antigenic epitopes with some bacterial and viral antigens. Campylobacter jejuni infection is associated with an axonal-onset variant; affected patients commonly experience more rapid deterioration. Many other antecedent infectious agents have been recognized including the most recently identified, Zika virus. Supportive care remains the mainstay of therapy. Plasma exchange or intravenous immunoglobin hastens recovery. Combination immunotherapy is not more effective, and the efficacy of prolonged immunotherapy is unproven. One in 3 patients will have deterioration severe enough to require prolonged intensive care monitoring or mechanical ventilation. Full recovery is often seen; most patients regain ambulation, even in severe cases, but disability remains in up to 10% and perhaps more. Numerous challenges remain including early identification and control of infectious triggers, improved access of modern neurointensive care worldwide, and translating our understanding of pathogenesis into meaningful preventive or assistive therapies. This review provides a historical perspective at the centenary of the first description of the syndrome, insights into its pathogenesis, triage, initial immunotherapy, and management in the intensive care unit. Copyright © 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

AIDS and Teenagers: Emerging Issues. Hearing before the Select Committee on Children, Youth, and Families. House of Representatives, One Hundredth Congress, First Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Select Committee on Children, Youth, and Families.

This document presents testimonies from the Congressional hearing examining the Acquired Immunodeficiency Syndrome (AIDS) crisis and its impact on teenagers. Opening remarks from Representatives George Miller, Dan Coats, Ted Weiss, Ron Packard, and J. Roy Rowland stress the importance of determining how to protect adolescents from AIDS. C. Everett…

The muscular dystrophies associated with central nervous system lesions: a brief review from a standpoint of the localization and function of causative genes.

PubMed

Yamamoto, Tomoko; Hiroi, Atsuko; Osawa, Makiko; Shibata, Noriyuki

2014-01-01

The muscular dystrophies have been traditionally classified based mainly on clinical manifestation and mode of inheritance. Owing to the discoveries of causative genes, new terminologies derived from each gene, such as dystrophinopathy, α-dystroglycanopathy, sarcoglycanopathy and fukutinopathy, have also become common. Mutations of each gene may cause several clinical phenotypes. Some muscular dystrophies accompany central nervous system (CNS) lesions, especially in the congenital muscular dystrophies. Cobblestone lissencephaly (type II lissencephaly) is a well-known CNS malformation observed in severe forms of α-dystroglycanopathy. Moreover, CNS involvement has been reported in other muscular dystrophies, such as Duchenne muscular dystrophy. In this review, genes related to the muscular dystrophies associated with CNS lesions are briefly described along with the molecular characteristics of each gene and the pathomechanism of the CNS lesions. Understanding of both the clinicopathological characteristics of these CNS lesions and their molecular mechanisms is important for the diagnosis, care of patients, and development of new therapeutic strategies.

The Effect of Mild Motion Sickness and Sopite Syndrome on Multitasking Cognitive Performance

DTIC Science & Technology

2013-03-01

Ledin, & Falkmer, 2009), in command and control tasks ( Cowings , Toscano, DeRoshia, & Tauson, 2001), or in visual search (Golding & Kerguelen, 1992...common and frequent. Research has shown that drowsiness is among the most frequent symptoms associated with motion sickness ( Cowings et al., 2001...sickness ( Cowings , Naifeh, & Toscano, 1990; J. C. Miller, Sharkey, Graham, & McCauley, 1993). The following paragraphs will focus on the

Mechanics of the brain: perspectives, challenges, and opportunities.

PubMed

Goriely, Alain; Geers, Marc G D; Holzapfel, Gerhard A; Jayamohan, Jayaratnam; Jérusalem, Antoine; Sivaloganathan, Sivabal; Squier, Waney; van Dommelen, Johannes A W; Waters, Sarah; Kuhl, Ellen

2015-10-01

The human brain is the continuous subject of extensive investigation aimed at understanding its behavior and function. Despite a clear evidence that mechanical factors play an important role in regulating brain activity, current research efforts focus mainly on the biochemical or electrophysiological activity of the brain. Here, we show that classical mechanical concepts including deformations, stretch, strain, strain rate, pressure, and stress play a crucial role in modulating both brain form and brain function. This opinion piece synthesizes expertise in applied mathematics, solid and fluid mechanics, biomechanics, experimentation, material sciences, neuropathology, and neurosurgery to address today's open questions at the forefront of neuromechanics. We critically review the current literature and discuss challenges related to neurodevelopment, cerebral edema, lissencephaly, polymicrogyria, hydrocephaly, craniectomy, spinal cord injury, tumor growth, traumatic brain injury, and shaken baby syndrome. The multi-disciplinary analysis of these various phenomena and pathologies presents new opportunities and suggests that mechanical modeling is a central tool to bridge the scales by synthesizing information from the molecular via the cellular and tissue all the way to the organ level.

Diagnostic yield of the comprehensive assessment of developmental delay/mental retardation in an institute of child neuropsychiatry.

PubMed

Battaglia, A; Bianchini, E; Carey, J C

1999-01-01

The Consensus Conference of the American College of Medical Genetics has established guidelines regarding the evaluation of patients with mental retardation (MR) [Curry et al., Am. J. Med. Genet. 72:468-477, 1997]. They emphasized the high diagnostic utility of cytogenetic studies and of neuroimaging in certain clinical settings. However, data on the diagnostic yield of these studies in well-characterized populations of individuals with MR are scant. Majnemer and Shevell [J. Pediatr. 127:193-199, 1995] attained a diagnostic yield of 63%. However, this study included only 60 patients and the classification included pathogenetic and causal groups. The Stella Maris Institute has evaluated systematically patients with developmental delay (DD)/MR and performed various laboratory studies and neuroimaging in almost all patients. We report a retrospective analysis of the diagnostic yield of 120 consecutive patients observed at our Institute during the first 6 months of 1996. There were 77 males and 43 females; 47 were mildly delayed (IQ 70-50), 31 were moderately delayed (IQ 50-35), and 42 were severely delayed (IQ 35-20). Diagnostic studies (history, physical examination, standard cytogenetics, fragile X testing, molecular studies, electroencephalography, electromyography, nerve conduction studies, neuroimaging, and metabolic screening tests) yielded a causal diagnosis in 50 (41.6%) and a pathogenetic diagnosis in 47 (39.2%) of the 120 patients. Causal categories included chromosomal abnormalities (14), Fra(X) syndromes (4), known MCA/MR syndromes (19), fetal environmental syndromes (1), neurometabolic (3) disorders, neurocutaneous (3) disorders, hypoxic-ischemic encephalopathy (3), other encephalopathies (1), and congenital bilateral perisylvian syndrome (2). Pathogenetic categories included idiopathic MCA/MR syndromes (35), epileptic syndromes (10), and isolated lissencephaly sequence (2). Diagnostic yield did not differ across categories and degree of DD. Our results, while confirming the diagnostic utility of cytogenetic/molecular genetic, and neuroimaging studies, suggest the usefulness of accurate electroencephalogram recordings, and stress the importance of a thorough physical examination. Referral to a university child neurology and psychiatry service, where a comprehensive assessment with a selected battery of investigations is possible, yields etiologic findings in a high percentage of DD/MR patients, with important implications for management, prognosis and recurrence risk estimate.

Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs

PubMed Central

Dix, Carly I.; Soundararajan, Harish Chandra; Dzhindzhev, Nikola S.; Begum, Farida; Suter, Beat; Ohkura, Hiroyuki; Stephens, Elaine

2013-01-01

Microtubule-based transport mediates the sorting and dispersal of many cellular components and pathogens. However, the mechanisms by which motor complexes are recruited to and regulated on different cargos remain poorly understood. Here we describe a large-scale biochemical screen for novel factors associated with RNA localization signals mediating minus end–directed mRNA transport during Drosophila development. We identified the protein Lissencephaly-1 (Lis1) and found that minus-end travel distances of localizing transcripts are dramatically reduced in lis1 mutant embryos. Surprisingly, given its well-documented role in regulating dynein mechanochemistry, we uncovered an important requirement for Lis1 in promoting the recruitment of dynein and its accessory complex dynactin to RNA localization complexes. Furthermore, we provide evidence that Lis1 levels regulate the overall association of dynein with dynactin. Our data therefore reveal a critical role for Lis1 within the mRNA localization machinery and suggest a model in which Lis1 facilitates motor complex association with cargos by promoting the interaction of dynein with dynactin. PMID:23918939

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

PubMed Central

Baumbach, Janina; Murthy, Andal; McClintock, Mark A; Dix, Carly I; Zalyte, Ruta; Hoang, Ha Thi; Bullock, Simon L

2017-01-01

The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we elucidate in vitro the roles of dynactin, end-binding protein-1 (EB1) and Lissencephaly-1 (LIS1) in the interaction of end tracking and minus end-directed human dynein complexes with these sites. LIS1 promotes dynactin-dependent tracking of dynein on both growing and shrinking plus ends. LIS1 also increases the frequency and velocity of processive dynein movements that are activated by complex formation with dynactin and a cargo adaptor. This stimulatory effect of LIS1 contrasts sharply with its documented ability to inhibit the activity of isolated dyneins. Collectively, our findings shed light on how mammalian dynein complexes associate with dynamic microtubules and help clarify how LIS1 promotes the plus-end localisation and cargo transport functions of dynein in vivo. DOI: http://dx.doi.org/10.7554/eLife.21768.001 PMID:28406398

A Case of Fisher-Bickerstaff Syndrome Overlapped by Guillain-Barré Syndrome

PubMed Central

Fujii, Daiki; Manabe, Yasuhiro; Takahasi, Yosiaki; Narai, Hisashi; Omori, Nobuhiko; Kusunoki, Susumu; Abe, Koji

2012-01-01

We report a 72-year-old woman with overlapping Miller Fisher syndrome (MFS), Guillain-Barré syndrome (GBS) and Bickerstaff's brainstem encephalitis (BBE). She developed diplopia and unsteady gait a week after an upper respiratory infection on day 1. She had weakness of both upper limbs on day 3 and became drowsy, and her respiratory status worsened on day 5. Neurologic examination revealed ophthalmoplegia, ataxia, symmetrical weakness, areflexia, and consciousness disturbance. We diagnosed her with MFS on day 1, GBS on day 3 and overlapping BBE on day 5. She underwent immunoadsorption therapy and two courses of intravenous immunoglobulin therapy. Ten months after onset, her symptoms had fully recovered. Anti-GM1 IgG, GD1a IgG, GQ1b IgG, and GT1a IgG antibodies were positive. Our case supports the notion that MFS, GBS, and BBE are all part of a continuous clinical spectrum, which is an antibody-mediated process. PMID:23275783

Distinct Immunoglobulin Class and Immunoglobulin G Subclass Patterns against Ganglioside GQ1b in Miller Fisher Syndrome following Different Types of Infection

PubMed Central

Schwerer, Beatrix; Neisser, Andrea; Bernheimer, Hanno

1999-01-01

We studied serum antibodies against gangliosides GQ1b and GM1 in 13 patients with Miller Fisher syndrome (MFS) and in 18 patients with Guillain-Barré syndrome (GBS) with cranial nerve involvement. Anti-GQ1b titers were elevated in all patients with MFS cases (immunoglobulin G [IgG] > IgA, IgM), and in 8 of the 18 with GBS. Lower frequencies of increased anti-GM1 titers were observed in MFS patients (3 of 13), as well as in GBS patients (5 of 18). During the course of MFS, anti-GQ1b titers of all Ig classes decreased within 3 weeks after onset. By contrast, anti-GM1 titers (mainly IgM) transiently increased during the course of MFS in five of six patients, suggesting a nonspecific secondary immune response. In patients with MFS following respiratory infections, IgG was the major anti-GQ1b Ig class (six of six patients) and IgG3 was the major subclass (five of six). In contrast, four of five patients with MFS following gastrointestinal infections showed predominance of anti-GQ1b IgA or IgM over IgG and predominance of the IgG2 subclass; anti-GQ1b IgG (IgG3) prevailed in one patient only. These distinct Ig patterns strongly suggest that different infections may trigger different mechanisms of anti-GQ1b production, such as via T-cell-dependent as opposed to T-cell-independent pathways. Thus, the origin of antibodies against GQ1b in MFS may be determined by the type of infectious agent that precipitates the disease. PMID:10225903

Guillain-Barré Syndrome and Variants

PubMed Central

Barohn, Richard J.

2014-01-01

Synopsis Guillain-Barré syndrome (GBS) is characterized by rapidly evolving ascending weakness, mild sensory loss and hypo- or areflexia, progressing to a nadir over up to four weeks. Cerebrospinal fluid evaluation demonstrates albuminocytologic dissociation in 90% of cases. Acute inflammatory demyelinating polyneuropathy (AIDP) was the first to be recognized over a century ago and is the most common form of GBS. In AIDP, the immune attack is directed at peripheral nerve myelin with secondary by-stander axon loss. Axonal motor and sensorimotor variants have been described in the last 3 decades and are mediated by molecular mimicry targeting peripheral nerve motor axons. Besides the Miller-Fisher syndrome (MFS) and descending weakness, other rare phenotypic variants have been recently described with pure sensory variant, restricted autonomic manifestations and the pharyngeal-cervical-brachial pattern. It is important to recognize GBS and its variants due to the availability of equally effective therapies in the form of plasmapheresis and intravenous immunoglobulins. PMID:23642721

Elisa Miller | NREL

Science.gov Websites

Elisa Miller Photo of Elisa Miller Elisa Link-Miller Researcher III-Chemistry Elisa.Miller@nrel.gov | 303-384-6777 Dr. Elisa Miller-Link studies the surface of semiconductors that are applicable for , and other nanocrystalline films. Elisa came to NREL in 2013 as an NREL Director's Fellowship recipient

Hannah Miller | NREL

Science.gov Websites

Hannah Miller desc Hannah Miller Group Administrative Assistant Hannah.Miller@nrel.gov | 303-275 -3671 Hannah Miller is staff support for the Applied Engineering and Modeling Group in the Integrated Applications Center. Hannah is a former office manager, communications director, and sales consultant for

Cystic kidneys in fetal Walker-Warburg syndrome with POMT2 mutation: Intrafamilial phenotypic variability in four siblings and review of literature.

PubMed

Nabhan, Marwa M; ElKhateeb, Nour; Braun, Daniela A; Eun, Sungho; Saleem, Sahar N; YungGee, Heon; Hildebrandt, Friedhelm; Soliman, Neveen A

2017-10-01

Walker-Warburg syndrome (WWS) is a severe form of congenital muscular dystrophy secondary to α-dystroglycanopathy with muscle, brain, and eye abnormalities often leading to death in the first weeks of life. It is transmitted in an autosomal recessive pattern, and has been linked to at least 15 different genes; including protein O-mannosyltransferase 1 (POMT1), protein O-mannosyltransferase 2 (POMT2), protein O-mannose beta-1,2-N acetylglucosaminyltransferase (POMGNT1), fukutin (FKTN), isoprenoid synthase domain-containing protein (ISPD), and other genes. We report on a consanguineous family with four consecutive siblings affected by this condition with lethal outcome in three (still birth), and termination of the fourth pregnancy based on antenatal MRI identification of brain and kidney anomalies that heralded proper and deep clinical phenotyping. The diagnosis of WWS was suggested based on the unique collective phenotype comprising brain anomalies in the form of lissencephaly, subcortical/subependymal heterotopia, and cerebellar hypoplasia shared by all four siblings; microphthalmia in one sibling; and large cystic kidneys in the fetus and another sibling. Other unshared neurological abnormalities included hydrocephalus and Dandy-Walker malformation. Whole exome sequencing of the fetus revealed a highly conserved missense mutation in POMT2 that is known to cause WWS with brain and eye anomalies.In conclusion, the heterogeneous clinical presentation in the four affected conceptions with POMT2 mutation expands the current clinical spectrum of POMT2-associated WWS to include large cystic kidneys; and confirms intra-familial variability in terms of brain, kidney, and eye anomalies. © 2017 Wiley Periodicals, Inc.

Human radiation studies: Remembering the early years. Oral history of radiologist Earl R. Miller, M.D., August 9 and 17, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-06-01

Dr. Earl R. Miller was interviewed by representatives of US DOE Office of Human Radiation Research (OHRE). The interview covers Dr. Miller`s involvement with the Manhattan Engineer District, with total body irradiation, and heavy-ion therapy. Dr. Miller`s remembrances include wartime work on radiation exposure, Joe Hamilton, Neutron Therapy research, means of obtaining isotopes, consent forms, infinite laminograms, invention of a baby holder to alleviate exposure of radiological technicians in diagnostic procedures involving infants, and several personages.

Lissencephaly: expanded imaging and clinical classification

PubMed Central

Di Donato, Nataliya; Chiari, Sara; Mirzaa, Ghayda M.; Aldinger, Kimberly; Parrini, Elena; Olds, Carissa; Barkovich, A. James; Guerrini, Renzo; Dobyns, William B.

2017-01-01

Lissencephaly (“smooth brain”, LIS) is a malformation of cortical development associated with deficient neuronal migration and abnormal formation of cerebral convolutions or gyri. The LIS spectrum includes agyria, pachygyria, and subcortical band heterotopia. Our first classification of LIS and subcortical band heterotopia (SBH) was developed to distinguish between the first two genetic causes of LIS – LIS1 (PAFAH1B1) and DCX. However, progress in molecular genetics has led to identification of 19 LIS-associated genes, leaving the existing classification system insufficient to distinguish the increasingly diverse patterns of LIS. To address this challenge, we reviewed clinical, imaging and molecular data on 188 patients with LIS-SBH ascertained during the last five years, and reviewed selected archival data on another ~1,400 patients. Using these data plus published reports, we constructed a new imaging based classification system with 21 recognizable patterns that reliably predict the most likely causative genes. These patterns do not correlate consistently with the clinical outcome, leading us to also develop a new scale useful for predicting clinical severity and outcome. Taken together, our work provides new tools that should prove useful for clinical management and genetic counselling of patients with LIS-SBH (imaging and severity based classifications), and guidance for prioritizing and interpreting genetic testing results (imaging based classification). PMID:28440899

Ocular abnormalities in congenital Zika syndrome: are the ophthalmoscopic findings "the top of the iceberg"?

PubMed

de Oliveira Dias, João Rafael; Ventura, Camila V; de Paula Freitas, Bruno; Prazeres, Juliana; Ventura, Liana O; Bravo-Filho, Vasco; Aleman, Tomas; Ko, Albert Icksang; Zin, Andréa; Belfort, Rubens; Maia, Mauricio

2018-04-23

Zika virus (ZIKV) is an arbovirus mainly transmitted to humans by mosquitoes from Aedes genus. Other ways of transmission include the perinatal and sexual routes, blood transfusion, and laboratory exposure. Although the first human cases were registered in 1952 in African countries, outbreaks were only reported since 2007, when entire Pacific islands were affected. In March 2015, the first cases of ZIKV acute infection were notified in Brazil and, to date, 48 countries and territories in the Americas have confirmed local mosquito-borne transmission of ZIKV. Until 2015, ZIKV infection was thought to only cause asymptomatic or mild exanthematous febrile infections. However, after explosive ZIKV outbreaks in Polynesia and Latin American countries, it was confirmed that ZIKV could also lead to Guillain-Barré syndrome and congenital birth abnormalities. These abnormalities, which can include neurologic, ophthalmologic, audiologic, and skeletal findings, are now considered congenital Zika syndrome (CZS). Brain abnormalities in CZS include cerebral calcifications, malformations of cortical development, ventriculomegaly, lissencephaly, hypoplasia of the cerebellum and brainstem. The ocular findings, which are present in up to 70% of infants with CZS, include iris coloboma, lens subluxation, cataract, congenital glaucoma, and especially posterior segment findings. Loss of retinal pigment epithelium, the presence of a thin choroid, a perivascular choroidal inflammatory infiltrate, and atrophic changes within the optic nerve were seen in histologic analyses of eyes from deceased fetuses. To date, there is no ZIKV licensed vaccines or antiviral therapies are available for treatment. Preventive measures include individual protection from mosquito bites, control of mosquito populations and the use of barriers measures such as condoms during sexual intercourse or sexual abstinence for couples either at risk or after confirmed infection. A literature review based on studies that analyzed ocular findings in mothers and infants with CZS, with or without microcephaly, was conducted and a theoretical pathophysiologic explanation for ZIKV-ocular abnormalities was formulated. Copyright © 2018. Published by Elsevier Ltd.

The Role of ARX in Human Pancreatic Endocrine Specification

PubMed Central

Gage, Blair K.; Asadi, Ali; Baker, Robert K.; Webber, Travis D.; Wang, Rennian; Itoh, Masayuki; Hayashi, Masaharu; Miyata, Rie; Akashi, Takumi; Kieffer, Timothy J.

2015-01-01

The in vitro differentiation of human embryonic stem cells (hESCs) offers a model system to explore human development. Humans with mutations in the transcription factor Aristaless Related Homeobox (ARX) often suffer from the syndrome X-linked lissencephaly with ambiguous genitalia (XLAG), affecting many cell types including those of the pancreas. Indeed, XLAG pancreatic islets lack glucagon and pancreatic polypeptide-positive cells but retain somatostatin, insulin, and ghrelin-positive cells. To further examine the role of ARX in human pancreatic endocrine development, we utilized genomic editing in hESCs to generate deletions in ARX. ARX knockout hESCs retained pancreatic differentiation capacity and ARX knockout endocrine cells were biased toward somatostatin-positive cells (94% of endocrine cells) with reduced pancreatic polypeptide (rarely detected), glucagon (90% reduced) and insulin-positive (65% reduced) lineages. ARX knockout somatostatin-positive cells shared expression patterns with human fetal and adult δ-cells. Differentiated ARX knockout cells upregulated PAX4, NKX2.2, ISL1, HHEX, PCSK1, PCSK2 expression while downregulating PAX6 and IRX2. Re-expression of ARX in ARX knockout pancreatic progenitors reduced HHEX and increased PAX6 and insulin expression following differentiation. Taken together these data suggest that ARX plays a key role in pancreatic endocrine fate specification of pancreatic polypeptide, somatostatin, glucagon and insulin positive cells from hESCs. PMID:26633894

The Role of ARX in Human Pancreatic Endocrine Specification.

PubMed

Gage, Blair K; Asadi, Ali; Baker, Robert K; Webber, Travis D; Wang, Rennian; Itoh, Masayuki; Hayashi, Masaharu; Miyata, Rie; Akashi, Takumi; Kieffer, Timothy J

2015-01-01

The in vitro differentiation of human embryonic stem cells (hESCs) offers a model system to explore human development. Humans with mutations in the transcription factor Aristaless Related Homeobox (ARX) often suffer from the syndrome X-linked lissencephaly with ambiguous genitalia (XLAG), affecting many cell types including those of the pancreas. Indeed, XLAG pancreatic islets lack glucagon and pancreatic polypeptide-positive cells but retain somatostatin, insulin, and ghrelin-positive cells. To further examine the role of ARX in human pancreatic endocrine development, we utilized genomic editing in hESCs to generate deletions in ARX. ARX knockout hESCs retained pancreatic differentiation capacity and ARX knockout endocrine cells were biased toward somatostatin-positive cells (94% of endocrine cells) with reduced pancreatic polypeptide (rarely detected), glucagon (90% reduced) and insulin-positive (65% reduced) lineages. ARX knockout somatostatin-positive cells shared expression patterns with human fetal and adult δ-cells. Differentiated ARX knockout cells upregulated PAX4, NKX2.2, ISL1, HHEX, PCSK1, PCSK2 expression while downregulating PAX6 and IRX2. Re-expression of ARX in ARX knockout pancreatic progenitors reduced HHEX and increased PAX6 and insulin expression following differentiation. Taken together these data suggest that ARX plays a key role in pancreatic endocrine fate specification of pancreatic polypeptide, somatostatin, glucagon and insulin positive cells from hESCs.

Top-100 cited articles on Guillain-Barré syndrome: a bibliometric analysis.

PubMed

Kim, Jee-Eun; Kim, Jong Kuk; Park, Kang Min; Kim, Yerim; Yoon, Dae Young; Bae, Jong Seok

2016-12-01

Since the first description of Guillain-Barré syndrome (GBS) 100 years ago, the concept of this syndrome has changed remarkably. The purpose of our study was to identify and characterize the most-cited articles that have contributed to advancing the understanding of GBS. Based on the database of Journal Citation Reports, we selected 554 journals that were considered as potential sources of reports on studies related to clinical neurology and general medicine. The Web of Science search tools were used to identify the most-cited articles relevant to GBS or other variants in the selected journals. Of the selected articles, 18 were review articles and the remainder were original articles or included only a few case series. Among the original articles, 13 described basic research associated with immunological pathogenesis involving anti-ganglioside antibodies. Most of the original studies (42/64, 66%) published after 1990 evaluated anti-ganglioside antibodies that mediated axonal GBS or Miller Fisher syndrome, with only a small number of the papers involving electrodiagnostic medicine (n = 4). Our bibliometric analysis has yielded a detailed list of the top-100 cited articles in the field of GBS. © 2016 Peripheral Nerve Society.

The art and science of switching antipsychotic medications, part 2.

PubMed

Weiden, Peter J; Miller, Alexander L; Lambert, Tim J; Buckley, Peter F

2007-01-01

In the presentation "Switching and Metabolic Syndrome," Weiden summarizes reasons to switch antipsychotics, highlighting weight gain and other metabolic adverse events as recent treatment targets. In "Texas Medication Algorithm Project (TMAP)," Miller reviews the TMAP study design, discusses results related to the algorithm versus treatment as usual, and concludes with the implications of the study. Lambert's presentation, "Dosing and Titration Strategies to Optimize Patient Outcome When Switching Antipsychotic Therapy," reviews the decision-making process when switching patients' medication, addresses dosing and titration strategies to effectively transition between medications, and examines other factors to consider when switching pharmacotherapy.

Exact simulation of max-stable processes.

PubMed

Dombry, Clément; Engelke, Sebastian; Oesting, Marco

2016-06-01

Max-stable processes play an important role as models for spatial extreme events. Their complex structure as the pointwise maximum over an infinite number of random functions makes their simulation difficult. Algorithms based on finite approximations are often inexact and computationally inefficient. We present a new algorithm for exact simulation of a max-stable process at a finite number of locations. It relies on the idea of simulating only the extremal functions, that is, those functions in the construction of a max-stable process that effectively contribute to the pointwise maximum. We further generalize the algorithm by Dieker & Mikosch (2015) for Brown-Resnick processes and use it for exact simulation via the spectral measure. We study the complexity of both algorithms, prove that our new approach via extremal functions is always more efficient, and provide closed-form expressions for their implementation that cover most popular models for max-stable processes and multivariate extreme value distributions. For simulation on dense grids, an adaptive design of the extremal function algorithm is proposed.

Blood donation before surgery

MedlinePlus

... EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice . 7th ed. Philadelphia, PA: Elsevier; 2018:chap 111. Miller RD. Patient blood management: transfusion therapy. In: Miller RD, ed. Miller's Anesthesia . ...

Emanuel Miller lecture: confusions and controversies about Asperger syndrome.

PubMed

Frith, Uta

2004-05-01

Hans Asperger drew attention to individuals who show the core symptoms of autism in the presence of high verbal intelligence. A review of the literature explores current issues concerning the diagnosis and nature of Asperger syndrome. The behavioural and neurophysiological evidence to date suggests that Asperger syndrome is a variant of autism typically occurring in high-functioning individuals, and not a separate disorder. One of the problems of diagnosis is that the typical impairment of social communication may be difficult to identify in early childhood, and can be camouflaged in adulthood by compensatory learning. The range and nature of the social impairments in Asperger syndrome are still in need of investigation, but appear to be less severe than in autism. Experimental evidence suggests that individuals with Asperger syndrome may lack an intuitive theory of mind (mentalising), but may be able to acquire an explicit theory of mind. Brain imaging studies pinpoint a network that links medial prefrontal and temporal cortex as the neural substrate of intuitive mentalising. This network shows reduced activation and poor connectivity in Asperger syndrome. While some individuals with Asperger syndrome have written eloquently about their lives, their ability to talk about their own emotions appears to be impaired (alexithymia). This impairment may be linked to depression and anxiety, which is common in adulthood. Little is as yet known about the often considerable cognitive strengths in Asperger syndrome, or about the difficulties observed in higher-level executive skills. Studies are needed that define the developmental course of the disorder and the nature of the strengths and weaknesses in both social and non-social domains. This requires more sensitive assessment instruments than are currently available. Questions about the prevalence of Asperger syndrome, about associated and secondary features, and about optimal education and management, urgently call for such studies.

Guillain-Barré syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccine: multinational case-control study in Europe

PubMed Central

Dieleman, Jeanne; Romio, Silvana; Johansen, Kari; Weibel, Daniel; Bonhoeffer, Jan

2011-01-01

Objective To assess the association between pandemic influenza A (H1N1) 2009 vaccine and Guillain-Barré syndrome. Design Case-control study. Setting Five European countries. Participants 104 patients with Guillain-Barré syndrome and its variant Miller-Fisher syndrome matched to one or more controls. Case status was classified according to the Brighton Collaboration definition. Controls were matched to cases on age, sex, index date, and country. Main outcome measures Relative risk estimate for Guillain-Barré syndrome after pandemic influenza vaccine. Results Case recruitment and vaccine coverage varied considerably between countries; the most common vaccines used were adjuvanted (Pandemrix and Focetria). The unadjusted pooled risk estimate for all countries was 2.8 (95% confidence interval 1.3 to 6.0). After adjustment for influenza-like illness/upper respiratory tract infection and seasonal influenza vaccination, receipt of pandemic influenza vaccine was not associated with an increased risk of Guillain-Barré syndrome (adjusted odds ratio 1.0, 0.3 to 2.7). The 95% confidence interval shows that the absolute effect of vaccination could range from one avoided case of Guillain-Barré syndrome up to three excess cases within six weeks after vaccination in one million people. Conclusions The risk of occurrence of Guillain-Barré syndrome is not increased after pandemic influenza vaccine, although the upper limit does not exclude a potential increase in risk up to 2.7-fold or three excess cases per one million vaccinated people. When assessing the association between pandemic influenza vaccines and Guillain-Barré syndrome it is important to account for the effects of influenza-like illness/upper respiratory tract infection, seasonal influenza vaccination, and calendar time. PMID:21750072

Tailored Communication to Enhance Adaption Across the Breast Cancer Spectrum

DTIC Science & Technology

2005-10-01

cancer risk assessment programs and adherence to screening recommendations among underserved African- American women; 2) use of a "teachable moment...cancer represents a serious health issue for African American women. Higher morbidity and mortality rates in this population may be due, in part, to...recommendations among African American women (Miller, 1995; Miller, 1996; Miller, Shoda, & Hurley, 1996; Miller, Fang, et al., 1999). These data will be used

Cranial Neuropathies and Neuromuscular Weakness: A Case of Mistaken Identity

PubMed Central

Adams, Daniel Z.; King, Andrew; Kaide, Colin

2017-01-01

We describe a case of wound botulism initially thought to represent Miller-Fisher variant Guillain-Barré syndrome (MFS). Botulism classically presents with the so-called “four D’s” (diplopia, dysarthria, dysphagia, dry mouth) with symmetric, descending weakness. MFS presents with a triad of limb-ataxia, areflexia, and ophthalmoplegia, with variable cranial nerve and extremity involvement. The distinction can be difficult but is important as early initiation of botulinum antitoxin is associated with improved patient outcomes in cases of botulism. Furthermore, it is important to recognize intravenous drug use as a risk factor in the development of botulism, especially given an increase in injection drug use. PMID:29849352

Cranial Neuropathies and Neuromuscular Weakness: A Case of Mistaken Identity.

PubMed

Adams, Daniel Z; King, Andrew; Kaide, Colin

2017-08-01

We describe a case of wound botulism initially thought to represent Miller-Fisher variant Guillain-Barré syndrome (MFS). Botulism classically presents with the so-called "four D's" (diplopia, dysarthria, dysphagia, dry mouth) with symmetric, descending weakness. MFS presents with a triad of limb-ataxia, areflexia, and ophthalmoplegia, with variable cranial nerve and extremity involvement. The distinction can be difficult but is important as early initiation of botulinum antitoxin is associated with improved patient outcomes in cases of botulism. Furthermore, it is important to recognize intravenous drug use as a risk factor in the development of botulism, especially given an increase in injection drug use.

Does the Miller blade truly provide a better laryngoscopic view and intubating conditions than the Macintosh blade in small children?

PubMed

Varghese, Elsa; Kundu, Ratul

2014-08-01

Both Miller and Macintosh blades are widely used for laryngoscopy in small children, though the Miller blade is more commonly recommended in pediatric anesthetic literature. The aim of this study was to compare laryngoscopic views and ease and success of intubation with Macintosh and Miller blades in small children under general anesthesia. One hundred and twenty children aged 1-24 months were randomized for laryngoscopy to be performed in a crossover manner with either the Miller or the Macintosh blade first, following induction of anesthesia and neuromuscular blockade. The tips of both the blades were placed at the vallecula. Intubation was performed following the second laryngoscopy. The glottic views with and without external laryngeal maneuver (ELM) and ease of intubation were observed. Similar glottic views with both blades were observed in 52/120 (43%) children, a better view observed with the Miller blade in 35/120 (29%) children, and with the Macintosh blade in 33/120 (28%). Laryngoscopy was easy in 65/120 (54%) children with both the blades. Restricted laryngoscopy was noted in 55 children: in 27 children with both the blades, 15 with Miller, and 13 with Macintosh blade. Laryngoscopic view improved following ELM with both the blades. In children aged 1-24 months, the Miller and the Macintosh blades provide similar laryngoscopic views and intubating conditions. When a restricted view is obtained, a change of blade may provide a better view. Placing the tip of the Miller blade in the vallecula provides satisfactory intubating conditions in this age group. © 2014 John Wiley & Sons Ltd.

'The Right Time and the Right Place': An Interview with Jacques Miller.

PubMed

Anderson, Warwick

2016-01-01

Professor Jacques F.P. Miller spoke about his career in immunology with Warwick Anderson on 3 February 2014. Born in Nice, France, Miller attended high school and medical school in Sydney, Australia. As a Ph.D. student and postgraduate researcher in London, Miller discovered the immunological function of the thymus gland. Spending the rest of his career at the Walter and Eliza Hall Institute for Medical Research in Melbourne, Miller conducted pioneering research in lymphocyte population dynamics and the mechanisms of the human immune response. With Graham Mitchell, he demonstrated that mammalian lymphocytes can be divided into what became known as T cells and B cells, which interact to produce antibodies.

Straight video blades are advantageous than curved blades in simulated pediatric difficult intubation.

PubMed

Saracoglu, Kemal T; Eti, Zeynep; Kavas, Ayse D; Umuroglu, Tumay

2014-03-01

It is still controversial which laryngoscope may be a better option in unanticipated difficult airway in pediatric patients. The aim of the present study was to compare two direct and two video-assisted laryngoscope devices for the management of difficult pediatric airway. Forty-five anesthesiology residents and nurse anesthetists participated in the study. Macintosh, Miller, Storz Miller, and McGrath Mac curved laryngoscopes were used for tracheal intubation of 3-6-month Airsim Pierre Robin manikin. We compared the duration of successful intubation, number of attempts, glottic view grades, severity of dental trauma, the use of optimization maneuvers, and the difficulty of use of the devices with straight and curved laryngoscope blades. Successful intubation duration was significantly lower in Storz Miller device, and the number of intubation attempts was significantly higher in the Macintosh laryngoscope (P < 0.01). According to the Cormack and Lehane classification, Grades 1 and 2 glottic view was 20% for Macintosh and 40% for Miller laryngoscope, while it was 100% for Storz Miller and 80% for McGrath (P < 0.001). Difficulty VAS scores of Storz Miller device were significantly lower than the scores of Macintosh, Miller, and McGrath laryngoscopes (15.7 ± 14.89, 34.7 ± 26.44, 31.5 ± 26.74, 33.4 ± 26.67 mm, respectively; P < 0.01). The severity of dental trauma was significantly lower in Storz Miller compared with Macintosh, Miller, and McGrath laryngoscopes (0.96 ± 1.04, 1.67 ± 1.15, 1.38 ± 1.05, 1.42 ± 1.27, respectively; P < 0.01). Storz Miller laryngoscope was found to have advantages over the other laryngoscopes in regard to glottic view, duration of successful intubation, number of attempts, dental trauma severity, need for additional maneuvers, and ease of use. © 2013 John Wiley & Sons Ltd.

Prospective comparison of acute motor axonal neuropathy and acute inflammatory demyelinating polyradiculoneuropathy in 140 children with Guillain-Barré syndrome in India.

PubMed

Kalita, Jayantee; Kumar, Mritunjai; Misra, Usha K

2018-05-01

There have been few reports on subtypes of Guillain-Barré syndrome (GBS) in children. We compared clinical and laboratory findings of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). One hundred forty children with GBS were included. Based on nerve conduction study (NCS) findings, patients were subclassified as AIDP, AMAN, acute motor sensory axonal neuropathy (AMSAN), and equivocal. Clinically, 72.1% of patients had pure motor, 24.3% motor sensory, and 3.4% Miller Fisher syndrome. Based on NCS, 67.8% of patients had AIDP, 23.6% had AMAN, and 4.3% had AMSAN. By 3 months, 2.1% patients had died, 47.1% had complete recovery, and 24.3% had poor recovery (wheelchair-bound). Children with AMAN had more frequent lower limb weakness (P = 0.02) and a lower probability of complete recovery (P = 0.01) at 3 months than children with AIDP (56% vs. 30%). AIDP is the most common GBS subtype in children. It is characterized by better recovery at 3 months when compared with AMAN. Muscle Nerve 57: 761-765, 2018. © 2017 Wiley Periodicals, Inc.

Headache and Pain in Guillain-Barré Syndrome.

PubMed

Farmakidis, Constantine; Inan, Seniha; Milstein, Mark; Herskovitz, Steven

2015-08-01

While moderate and severe back or extremity pain is frequent in Guillain-Barré syndrome (GBS), headache appears to be uncommon. Most of the reports of headache in GBS place it in the context of the posterior reversible encephalopathy syndrome (PRES) which is increasingly recognized as a likely dysautonomia-related GBS complication. There are also a few reports of headache in the setting of increased CSF pressure and papilledema and in association with the Miller Fisher GBS variant. In comparison, back and extremity pain is highly prevalent. Aching muscle pain and neuropathic pain are the two most common of several pain types. Pain may be a heralding feature and has been described in patients as long as 2 years after disease onset. Pain management is a major axis of treatment in GBS. Gabapentin is a reasonable first-line choice, and opioid medications can be added for more severe pain but there are few clinical trials to inform specific recommendations. While the understanding of pain pathophysiology in GBS is incomplete, its prevalence and clinical impact are increasingly recognized and studied. Pain should be considered a cardinal manifestation of GBS along with acute, mostly symmetric weakness and diminished reflexes.

Investigating the Skoog-Miller Model for Organogenesis Using Sweet Potato Root Explants.

ERIC Educational Resources Information Center

Delany, William; And Others

1994-01-01

Describes an experiment in which groups of students in a plant tissue culture course worked together to test application of the Skoog-Miller model (developed by Skoog and Miller in regeneration of tobacco experiments to demonstrate organogenesis) to sweet potato root explants. (ZWH)

Stress and Specificity: Reply to Miller (2009)

ERIC Educational Resources Information Center

Denson, Thomas F.; Spanovic, Marija; Miller, Norman

2009-01-01

T. F. Denson, M. Spanovic, and N. Miller (2009) meta-analytically tested the hypotheses that specific appraisals and emotions would predict cortisol and immune responses to laboratory stressors and emotion inductions. Although the cortisol data supported the integrated specificity hypothesis, G. E. Miller (2009) raised questions concerning the…

Does Morality Harm Children? Alice Miller on Morality and Poisonous Pedagogy

ERIC Educational Resources Information Center

Fridley, William L.

2006-01-01

Alice Miller, the former psychoanalyst, has gained world renown for her controversial and provocative writings on child rearing. Miller contends that traditional child rearing practices--in schools, ecclesiastical settings, and the family--consist of physical and emotional cruelty that she labels "poisonous pedagogy." According to…

Ethical Realism: A Guide to Action?

ERIC Educational Resources Information Center

Matkin, Gary

2008-01-01

This article presents the author's response to Gary Miller's essay entitled "Ethical Realism and Continuing Education." In his essay, Dr. Miller has provided a valuable opportunity to reflect on the practice of continuing education (CE) leadership. Dr. Miller reviews six principles that are encapsulated in the concept of ethical realism, but are…

Legitimizing Technical Communication in English Departments: Carolyn Miller's "Humanistic Rationale for Technical Writing"

ERIC Educational Resources Information Center

Moore, Patrick

2006-01-01

Carolyn Miller's oft-cited "Humanistic Rationale for Technical Writing," published in 1979, tries to give technical communication faculty more cultural capital in English departments controlled by literature professors. Miller replaces a positivistic emphasis in technical communication pedagogy with rhetoric. She shows how technical knowledge is…

The Effects of Middle Ear Pressure on Hearing.

DTIC Science & Technology

1984-04-30

Miller, J,M.: Choline salicylate : Effects on cochlear function. Arch. Otolaryngol. 99: 304-308, 1974. *12. Miller, J.M. and Holmquist, J.: An animal model...for study of eustachian tube and middle ear function. Scand. Audiol. 3: 63-68, 1974. 13. McPherson, D. and Miller, J.: Salicylate ototoxicity in the

Malformations of cortical development: 3T magnetic resonance imaging features

PubMed Central

Battal, Bilal; Ince, Selami; Akgun, Veysel; Kocaoglu, Murat; Ozcan, Emrah; Tasar, Mustafa

2015-01-01

Malformation of cortical development (MCD) is a term representing an inhomogeneous group of central nervous system abnormalities, referring particularly to embriyological aspect as a consequence of any of the three developmental stages, i.e., cell proliferation, cell migration and cortical organization. These include cotical dysgenesis, microcephaly, polymicrogyria, schizencephaly, lissencephaly, hemimegalencephaly, heterotopia and focal cortical dysplasia. Since magnetic resonance imaging is the modality of choice that best identifies the structural anomalies of the brain cortex, we aimed to provide a mini review of MCD by using 3T magnetic resonance scanner images. PMID:26516429

33 CFR 110.79b - Millers Bay, Lake Winnebago, Oshkosh, WI

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Millers Bay, Lake Winnebago, Oshkosh, WI 110.79b Section 110.79b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.79b Millers Bay, Lake Winnebago...

33 CFR 110.79b - Millers Bay, Lake Winnebago, Oshkosh, WI.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Millers Bay, Lake Winnebago, Oshkosh, WI. 110.79b Section 110.79b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.79b Millers Bay, Lake Winnebago...

33 CFR 110.79b - Millers Bay, Lake Winnebago, Oshkosh, WI

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Millers Bay, Lake Winnebago, Oshkosh, WI 110.79b Section 110.79b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.79b Millers Bay, Lake Winnebago...

33 CFR 110.79b - Millers Bay, Lake Winnebago, Oshkosh, WI.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Millers Bay, Lake Winnebago, Oshkosh, WI. 110.79b Section 110.79b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.79b Millers Bay, Lake Winnebago...

33 CFR 110.79b - Millers Bay, Lake Winnebago, Oshkosh, WI

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Millers Bay, Lake Winnebago, Oshkosh, WI 110.79b Section 110.79b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.79b Millers Bay, Lake Winnebago...

Ordering Chaos: Eva Miller--Multnomah County Library, Portland, OR

ERIC Educational Resources Information Center

Library Journal, 2004

2004-01-01

Eva Miller has a knack for creating order out of disorder. She single-handedly brought Oregon's virtual reference service, Answerland, live in just under 90 days, says Rivkah Sass, now director of the Omaha Public Library. Miller created its web site, designed the graphics, developed marketing materials, and recruited and trained librarians--all…

J. Hillis Miller's Virtual Reality of Reading

ERIC Educational Resources Information Center

Fosso, Kurt; Harp, Jerry

2012-01-01

We set out to investigate Miller's curious assertion--curious for a deconstructionist committed to a critique of the old metaphysics of presence--that literary works preexist their being written down. We find a basis for this sense of the preexistence of the literary work in Miller's insights about the performative dynamics of reading and writing.…

Comparison of the laryngoscopy views with the size 1 Miller and Macintosh laryngoscope blades lifting the epiglottis or the base of the tongue in infants and children <2 yr of age.

PubMed

Passi, Y; Sathyamoorthy, M; Lerman, J; Heard, C; Marino, M

2014-11-01

Miller laryngoscope blades are preferred for laryngoscopy in infants and children <2 yr of age. Despite their long history, the laryngeal view with the Miller blade size 1 has never been compared with that with the Macintosh (MAC) blade in children. This prospective, single-blinded, randomized study was designed to compare the laryngeal views with the size 1 Miller and MAC blades in children <2 yr. With IRB approval, 50 ASA I and II children <2 yr undergoing elective surgery were enrolled. After an inhalation induction and neuromuscular block with i.v. rocuronium 0.5 mg kg(-1), two laryngeal views were obtained with a single blade (Miller or MAC) in each child: one lifting the epiglottis and another lifting the tongue base. The best laryngeal views in each blade position were photographed with a SONY(®) Cyber-shot camera and rated by a blinded anaesthesiologist using the percentage of glottic opening scale. The scores with the Miller blade lifting the epiglottis and the MAC blade lifting the tongue base were similar. The scores with the Miller blade lifting the epiglottis and the tongue base were similar. The scores for the MAC blade lifting the tongue base were greater than those lifting the epiglottis (95% confidence interval: 7.6-26.8) (P=0.0004). In infants and children <2 yr of age, optimal laryngeal views may be obtained with either the Miller size 1 blade lifting the epiglottis or with the Miller or MAC blades lifting the tongue base. NCT01717872 at Clinical Trials.gov. © The Author 2014. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Maslow and Miller: An Exploration of Gender and Affiliation in the Journey to Competence

ERIC Educational Resources Information Center

Coy, Doris Rhea; Kovacs-Long, Judith

2005-01-01

This article shows that although neither Abraham Maslow nor Jean Baker Miller reference each other in their writings, they are following different paths to the same conclusion: competence proceeds from connection. Miller and Maslow both describe a developmental model that applies equally to women and men. The conclusion of the authors of this…

Experience with Guillain-Barré syndrome in a neurological Intensive Care Unit.

PubMed

González, P; García, X; Guerra, A; Arango, J C; Delgado, H; Uribe, C S; Sará, J; López de Mesa, J C; Hernández, O

2016-01-01

Guillain-Barré syndrome, an acute polyradiculoneuropathy that presents with weakness and areflexia, is the most common cause of acute flaccid paralysis. In certain patients, respiratory failure is secondary to this disorder, eventually causing patients to require mechanical ventilation and experience additional complications due to diminished respiratory support and related mobility limitations. Prognoses for most of these cases are positive; treatment consists of basic support combined with plasmapheresis or administration of immunoglobulins. This study sought to describe the socio-demographic, clinical, laboratory and neurophysiological characteristics of patients with Guillain-Barré syndrome who were hospitalised in the Intensive Care Unit of the Neurological Institute of Colombia between 2006 and 2012. This study presents a case series. We surveyed 25 patients (32% female and 68% male) with Guillain-Barré syndrome and an average age of 54 years. Sixty per cent of these patients were admitted between days 3 and 7 after symptom onset; 64% had a history of respiratory infection and 20% had a history of intestinal infection. In addition, 84% of the patients presented with albuminocytological dissociation. We observed the following clinical subtypes of Guillain-Barré syndrome: inflammatory demyelinating polyneuropathy in 32%, acute motor-sensory axonal neuropathy in 28%, acute motor axonal neuropathy in 28%, and Miller Fisher syndrome in 12%. In this descriptive study of a group of critical care patients with GBS, results depended on patients' clinical severity at time of admission. Our findings are similar to results published in the international literature. Copyright © 2014 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome.

PubMed

Chimelli, Leila; Moura Pone, Sheila; Avvad-Portari, Elyzabeth; Farias Meira Vasconcelos, Zilton; Araújo Zin, Andrea; Prado Cunha, Daniela; Raposo Thompson, Nathalia; Lopes Moreira, Maria Elisabeth; Wiley, Clayton A; da Silva Pone, Marcos Vinicius

2018-03-01

During the Zika epidemic in Brazil, a baby was born at term with microcephaly and arthrogryposis. The mother had Zika symptoms at 10 weeks of gestation. At 17 weeks, ultrasound showed cerebral malformation and ventriculomegaly. At 24 weeks, the amniotic fluid contained ZIKV RNA and at birth, placenta and maternal blood were also positive using RT-qPCR. At birth the baby urine contained ZIKV RNA, whereas CSF at birth and urine at 17 days did not. Seizures started at 6 days. EEG was abnormal and CT scan showed cerebral atrophy, calcifications, lissencephaly, ventriculomegaly, and cerebellar hypoplasia. Bacterial sepsis at 2 months was treated. A sudden increase in head circumference occurred at 4 months necessitating ventricle-peritoneal shunt placement. At 5 months, the infant died with sepsis due to bacterial meningitis. Neuropathological findings were as severe as some of those found in neonates who died soon after birth, including hydrocephalus, destructive lesions/calcification, gliosis, abnormal neuronal migration, dysmaturation of nerve cells, hypomyelination, loss of descending axons, and spinal motor neurons. ZIKV RNA was detected only in frozen brain tissue using RT-qPCR, but infected cells were not detected by in situ hybridization. Progressive gliosis and microgliosis in the midbrain may have contributed to aqueduct compression and subsequent hydrocephalus. The etiology of progressive disease after in utero infection is not clear and requires investigation. © 2018 American Association of Neuropathologists, Inc. All rights reserved.

[Atypical Guillain-Barre syndrome clustering: is it necessary to reconsider the diagnostic criteria and microbiological protocol?

PubMed

Dominguez-Mayoral, A; Gutierrez, C; Lopez-Dominguez, J M; Eichau, S; Abril, J; Navarro-Mascarell, G; Quesada-Garcia, M A; Ramos, M; Alvarez-Lopez, M; Menendez-De Leon, C; Izquierdo, G

2017-05-01

Guillain-Barre syndrome is classically defined as a symmetrical ascending acute polyradiculoneuropathy, although there are atypical variants that make diagnosis difficult. The medical data of six patients in our hospital area are collected during the first quarter of 2013. Lumbar punctures, imaging, neurophysiological studies, ganglioside antibodies and serologies have been proposed in all cases. We focus on the atypical features as late hyporeflexia, increased frequency of asymmetry and distal paresis and initial fever. From a neurophysiological point of view, all patients presented sensorimotor axonal forms. The most consistent datas in early studies is the F wave's alteration. A Miller Fisher variant associated with faciocervicobraquial paresis and cerebral reversible vasoconstriction syndrome has been detected. A bilateral brachial paresis and lumbar polyradiculopathy in the context of influenza A infection is other interesting case. The saltatory variant with cranial nerve involvement and lower limbs paresis has been demonstrated in one patient. Bands in cerebrospinal fluid are positive in three cases and anti-ganglioside antibodies in one patient. The syndrome of inappropriate secretion of antidiuretic hormone may explain some of the hyponatremias registered. The first line of treatment are inmunoglobulins in all patients. Plasmapheresis exchanges has been used as an additional therapy in four cases. These clusters of six axonal cases with atypical clinical features justifies the need for knowledge of these variants in order to achieve an early treatment. Late hyporeflexia and brachialfaciocervico, saltatory and lumbar forms should be considered in the spectrum of Guillain-Barre syndrome. The etiological study should rule out a lots of pathogens as influenza A.

Workshop on Explosive and Propellant Combustion Mechanisms

DTIC Science & Technology

1991-07-01

Trubert, Decomposition and Combustion Measurements 30 R.S. Miller and A.W. Miziolek, High Energy Density Materials Combustion 56 T.B. Brill...arranging this activity came from Dr. R.S. Miller , Chief Scientist, Mechanics Division, ONR, and Dr. Bernard Finck, Head, New Molecules Section, Defense...34. Armstrong, in consultation with R.S. Miller , J. Boileau, and SNPE colleagues, arranged for the participation of U.S. scientists, especially

Miller Creek Demonstration Forest ecology activities - a teachers supplement to the field guide

Treesearch

Bill Schustrom; Reed Kuennen; Raymond C. Shearer

1998-01-01

Miller Creek, on the Flathead National Forest in northwestern Montana, is a demonstration forest, showing up to 30 years of forest change. This teachers supplement to the educational field guide (Miller Creek Demonstration Forest - a forest born of fire: a field guide; Gen. Tech. Rep. RMRS-GTR-7, 1998) outlines eight field and classroom activities that teach students a...

Unmanned Tactical Autonomous Control and Collaboration Coactive Design

DTIC Science & Technology

2016-06-01

AUTONOMOUS CONTROL AND COLLABORATION COACTIVE DESIGN by Matthew S. Zach June 2016 Thesis Advisor: Dan Boger Second Reader: Scot Miller...POSTGRADUATE SCHOOL June 2016 Approved by: Dan Boger, Ph.D. Thesis Advisor Scot Miller Second Reader Dan Boger, Ph.D...assistance, and mentoring, I remain most grateful. I begin by thanking Dr. Dan Boger and Scot Miller for taking me on as a thesis student. You

A Rare Cause of Short Stature: 3M Syndrome in a Patient with Novel Mutation in OBSL1 Gene.

PubMed

Keskin, Melikşah; Muratoğlu Şahin, Nursel; Kurnaz, Erdal; Bayramoğlu, Elvan; Savaş Erdeve, Şenay; Aycan, Zehra; Çetinkaya, Semra

2017-03-01

The Miller-McKusick-Malvaux (3M) syndrome is a rare autosomal disorder that can lead to short stature, dysmorphic features, and skeletal abnormalities with normal intelligence. A 16-month-old female patient had been referred to our clinic due to short stature. Case history revealed a birth weight of 1740 grams on the 39 th week of gestation, with a birth length of 42 cm and no prior hereditary conditions of clinical significance in her family. On physical examination, her length was 67 cm [-3.6 standard deviation (SD) score], weight 7.2 kg (-2.9 SD score), and head circumference 42 cm (below 3 rd percentile). She also had numerous characteristic physical features such as a triangular face, fleshy nose tip, a long philtrum, prominent mouth and lips, pointed chin, lumbar lordosis, and prominent heels. As her growth retardation had a prenatal onset and the physical examination results were suggestive of a characteristic profile, the diagnosis of 3M syndrome was strongly considered. Genetic assessment of the patient revealed a novel homozygous p.T45Nfs*40 mutation in the OBSL1 gene. It is recommended that physicians pay further attention to this condition in the differential diagnosis of children with severe short stature.

Clinical classification of 103 Japanese patients with Guillain-Barré syndrome.

PubMed

Wakerley, Benjamin R; Kokubun, N; Funakoshi, K; Nagashima, T; Hirata, K; Yuki, N

2016-10-15

Guillain-Barré syndrome (GBS) is the commonest cause of flaccid paralysis worldwide. Miller Fisher syndrome (MFS) is a variant of GBS characterized by ophthalmoplegia and ataxia. Together GBS and MFS form a continuum of discrete and overlapping subtypes, the frequency of which remains unknown. We retrospectively analysed the clinical features (antecedent symptoms, pattern of neurological weakness or ataxia, presence of hypersomnolence) of 103 patients at a single hospital in Japan. Patients were then classified according to new diagnostic criteria (Wakerley et al., 2014). Laboratory data (neurophysiology and anti-ganglioside antibody profiles) were also analysed. According to the new diagnostic criteria, the 103 patients could be classified as follows: classic GBS 73 (71%), pharyngeal-cervical-brachial weakness 2 (2%), acute pharyngeal weakness 0 (0%), paraparetic GBS 1 (1%), bifacial weakness with paraesthesias 1 (1%), polyneuritis cranialis 0 (0%), classic MFS 18 (17%), acute ophthalmoparesis 1 (1%), acute ptosis 0 (0%), acute mydriasis 0 (0%), acute ataxic neuropathy 1 (1%), Bickerstaff brainstem encephalitis 3 (3%), acute ataxic hypersomnolence 0 (0%), GBS and MFS overlap 1 (1%), GBS and Bickerstaff brainstem encephalitis overlap 1 (1%), MFS and pharyngeal-cervical-brachial weakness overlap 1 (1%). Application of the new clinical diagnostic criteria allowed accurate retrospective diagnosis and classification of GBS and MFS subtypes. Copyright © 2016. Published by Elsevier B.V.

Demyelinating Guillain-Barré syndrome recurs more frequently than axonal subtypes.

PubMed

Notturno, Francesca; Kokubun, Norito; Sekiguki, Yukari; Nagashima, Takahide; De Lauretis, Angelo; Yuki, Nobuhiro; Kuwabara, Satoshi; Uncini, Antonino

2016-06-15

Guillain-Barré syndrome (GBS) is considered a monophasic disorder yet recurrences occur in up to 6% of patients. We retrospectively studied an Italian-Japanese population of 236 GBS and 73 Miller Fisher syndrome (MFS) patients and searched for factors which may be associated with recurrence. A recurrent patient was defined as having at least two episodes that fulfilled the diagnostic criteria for GBS and MFS with an identifiable recovery after each episode and a minimum of 2months between episodes. Preceding Campylobacter jejuni (C. jejuni) infection and antiganglioside antibodies were also assessed. Seven (3%) recurrent GBS and one (1.4%) recurrent MFS patients were identified. In the individual patient the clinical features during episodes were usually similar varying in severity whereas the preceding infection differed. None of the patients had GBS in one episode and MFS in the recurrence or vice versa. Recurrent GBS patients, compared with monophasic GBS, did not have preceding diarrhea at the first episode and considering the electrophysiological subtypes, acute inflammatory demyelinating polyneuropathies recurred more frequently than axonal GBS (6.5% vs 0.9%, p=0.04). In conclusion in a GBS population with a balanced number of demyelinating and axonal subtypes less frequent diarrhea and demyelination at electrophysiology were associated with recurrence. Copyright © 2016. Published by Elsevier B.V.

Unmanned Tactical Autonomous Control and Collaboration (UTACC) Campaign of Experimentation

DTIC Science & Technology

2016-09-01

Boger Second Reader: Scot Miller THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public...from the NAVAL POSTGRADUATE SCHOOL September 2016 Approved by: Dan Boger, Ph.D. Thesis Advisor Scot Miller Second Reader...Erik Keim forms the bedrock of this thesis. Next, I would like to thank Dr. Dan Boger and Scot Miller for taking me on as a thesis candidate and

Unmanned Tactical Autonomous Control and Collaboration Measures of Performance and Measures of Effectiveness

DTIC Science & Technology

2016-09-01

September 2016 Thesis Advisor: Dan Boger Co-Advisor: Scot Miller THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved... Scot Miller Co-Advisor Dan Boger Chair, Information Sciences Department iv THIS PAGE INTENTIONALLY LEFT BLANK v ABSTRACT As the technological...The authors would like to thank their advisors, Scot Miller and Dr. Dan Boger, for their incredibly helpful guidance and feedback on the development

George A. Miller (1920-2012).

PubMed

Pinker, Steven

2013-09-01

Presents an obituary for George A. Miller (1920-2012). Miller ranks among the most important psychologists of the 20th century. In addition to writing one of the best known papers in the history of psychology ("The Magical Number Seven, Plus or Minus Two: Some Limits on Our Capacity for Processing Information," published in Psychological Review in 1956), Miller also fomented the cognitive revolution, invented psycholinguistics and cognitive psychology, imported powerful ideas from the theories of information, communication, grammar, semantics, and artificial intelligence, and left us a sparkling oeuvre that proves that a rigorous scientist needn't write in soggy prose. Honors rained down on Miller. APA gave him the Award for Distinguished Scientific Contributions (1963), the American Psychological Foundation Gold Medal Award for Life Achievement in Psychological Science (1990), the William James Book Award (1992, for The Science of Words), and the Award for Lifetime Contributions to Psychology (2003), and named a prize after him, as did the Cognitive Neuroscience Society. Miller was also honored by the Association for Psychological Science and the American Speech and Hearing Association. In 2000, he won the John P. McGovern Award in the Behavioral Sciences from the American Association for the Advancement of Science, and in 1991, the National Medal of Science, the country's highest scientific honor. © 2013 APA, all rights reserved.

Miller's Pyramid and Core Competency Assessment: A Study in Relationship Construct Validity.

PubMed

Williams, Betsy White; Byrne, Phil D; Welindt, Dillon; Williams, Michael V

2016-01-01

Continuous professional development relies on the link between performance and an educational process aimed at improving knowledge and skill. One of the most broadly used frameworks for assessing skills is Miller's Pyramid. This Pyramid has a series of levels of achievement beginning with knowledge (at the base) and ending with routine application in the clinical setting. The purpose of this study was to determine the degree of convergence of two measurement methods, one based on Miller's framework, the second using the Accreditation Council for Graduate Medical Education/American Board of Medical Specialties (ACGME/ABMS) Core Competency framework. The data were gathered from the faculty of a large, Midwestern regional health care provider and hospital system. Data from 264 respondents were studied. The 360° data were from raters of physicians holding supervisory roles in the organization. The scale items were taken from an instrument that has been validated for both structure and known group prediction. The Miller scale was purposely built for this application. The questions were designed to describe each level of the model. The Miller scale was reduced to a single dimension. This result was then regressed on the items from the 360° item ratings. Results of a multivariate analysis of variance isolated a significant relationship between the Miller's Pyramid score and the competency items (P < 0.001). These findings demonstrate a relationship between measures based on Miller's framework and behavioral measures based on the ABMS/ACGME core competencies. Equally important is the finding that while they are related they are not identical. These findings have implications for continuous professional development programing design.

Chemical Analysis of a "Miller-Type" Complex Prebiotic Broth. Part I: Chemical Diversity, Oxygen and Nitrogen Based Polymers

NASA Astrophysics Data System (ADS)

Wollrab, Eva; Scherer, Sabrina; Aubriet, Frédéric; Carré, Vincent; Carlomagno, Teresa; Codutti, Luca; Ott, Albrecht

2016-06-01

In a famous experiment Stanley Miller showed that a large number of organic substances can emerge from sparking a mixture of methane, ammonia and hydrogen in the presence of water (Miller, Science 117:528-529, 1953). Among these substances Miller identified different amino acids, and he concluded that prebiotic events may well have produced many of Life's molecular building blocks. There have been many variants of the original experiment since, including different gas mixtures (Miller, J Am Chem Soc 77:2351-2361, 1955; Oró Nature 197:862-867, 1963; Schlesinger and Miller, J Mol Evol 19:376-382, 1983; Miyakawa et al., Proc Natl Acad Sci 99:14,628-14,631, 2002). Recently some of Miller's remaining original samples were analyzed with modern equipment (Johnson et al. Science 322:404-404, 2008; Parker et al. Proc Natl Acad Sci 108:5526-5531, 2011) and a total of 23 racemic amino acids were identified. To give an overview of the chemical variety of a possible prebiotic broth, here we analyze a "Miller type" experiment using state of the art mass spectrometry and NMR spectroscopy. We identify substances of a wide range of saturation, which can be hydrophilic, hydrophobic or amphiphilic in nature. Often the molecules contain heteroatoms, with amines and amides being prominent classes of molecule. In some samples we detect ethylene glycol based polymers. Their formation in water requires the presence of a catalyst. Contrary to expectations, we cannot identify any preferred reaction product. The capacity to spontaneously produce this extremely high degree of molecular variety in a very simple experiment is a remarkable feature of organic chemistry and possibly prerequisite for Life to emerge. It remains a future task to uncover how dedicated, organized chemical reaction pathways may have arisen from this degree of complexity.

Evidence-based guideline: intravenous immunoglobulin in the treatment of neuromuscular disorders: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

PubMed

Patwa, H S; Chaudhry, V; Katzberg, H; Rae-Grant, A D; So, Y T

2012-03-27

To assess the evidence for the efficacy of IV immunoglobulin (IVIg) to treat neuromuscular disorders. The MEDLINE, Web of Science, and EMBASE databases were searched (1966-2009). Selected articles were rated according to the American Academy of Neurology's therapeutic classification of evidence scheme; recommendations were based on the evidence level. IVIg is as efficacious as plasmapheresis and should be offered for treating Guillain-Barré syndrome (GBS) in adults (Level A). IVIg is effective and should be offered in the long-term treatment of chronic inflammatory demyelinating polyneuropathy (Level A). IVIg is probably effective and should be considered for treating moderate to severe myasthenia gravis and multifocal motor neuropathy (Level B). IVIg is possibly effective and may be considered for treating nonresponsive dermatomyositis in adults and Lambert-Eaton myasthenic syndrome (Level C). Evidence is insufficient to support or refute use of IVIg in the treatment of immunoglobulin M paraprotein-associated neuropathy, inclusion body myositis, polymyositis, diabetic radiculoplexoneuropathy, or Miller Fisher syndrome, or in the routine treatment of postpolio syndrome or in children with GBS (Level U). IVIg combined with plasmapheresis should not be considered for treating GBS (Level B). More data are needed regarding IVIg efficacy as compared with other treatments/treatment combinations. Most studies concluded IVIg-related serious adverse effects were rare. Given the variable nature of these diseases, individualized treatments depending on patient need and physician judgment are important.

An eleven year old boy with pain abdomen and early morning neuroparalytic syndrome.

PubMed

Sharma, Milap; Kalia, Shaurya; Sharma, Seema

2016-08-01

An 11 year old boy presented with pain abdomen and tenderness all over body when he got up from sleep early in the morning and subsequently had one vomiting after 30 min. He had no other significant past medical history. The child was shifted to nearby health facility where he was managed as a case of acute abdomen on the basis of suggestive history and clinical findings. Within 2 h after the onset of clinical features suggestive of acute abdomen the patient went on to develop marked ptosis and flaccid quadriplegia. The young boy underwent a sequence of clinical tests which were noncontributory. Based on the clinical picture, a differential diagnosis of hypokalemic paralysis, botulism, Miller Fischer syndrome and EMNS were considered. Through exclusion, the most probable diagnosis for the symptoms was elapid envenomation hence he was started on anti-snake venom (ASV) with working diagnosis of EMNS. Within 2 h, he began to show improvement. This recovery with ASV suggests the possibility of elapid envenomation. Copyright © 2016 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Diagnosis of cystic fibrosis in the kindred of an infant with CFTR-related metabolic syndrome: importance of follow-up that includes monitoring sweat chloride concentrations over time.

PubMed

Williams, Sophia N; Nussbaum, Eliezer; Chin, Terry W; Do, Paul C M; Singh, Kathryn E; Randhawa, Inderpal

2014-03-01

Newly implemented newborn screening (NBS) programs in California have resulted in a large subset of patients in whom at least two cystic fibrosis transmembrane conductance regulator (CFTR) mutations are identified, but subsequent sweat chloride analysis reveals normal or indeterminate values. These patients are diagnosed with CFTR-Related Metabolic Syndrome (CRMS). However, the natural progression and management of these patients are not clearly understood and frequently after the age of 1-year these patients are lost to follow-up with Cystic Fibrosis (CF) Centers. We present the first case of an infant who was referred to Miller Children's Hospital for a NBS positive for CF and subsequent discovery of identical mutations in six of his seven older brothers. Several siblings had positive sweat chloride results on repeat testing after the age of 3 years. We suggest the need for continued follow-up of CRMS in a CF center with diagnostic evaluation including repeat sweat chloride testing, beyond the currently recommended period. © 2013 Wiley Periodicals, Inc.

DNS, LES and Stochastic Modeling of Turbulent Reacting Flows

DTIC Science & Technology

1994-03-01

NY, 1972. 3 [181 Miller , R. S., Frankel, S. H., Madnia, C. K., and Givi, P., Johnson-Edgeworth Trans- lation for Probability Modeling of Binary Mixing...Givi, " Modeling of Isotropic are also grateful to Richard Miller for many useful discussions. This Reacting Turbulence by a Hybrid Mapping-EDQNM...United State of America * Johnson-Edgeworth Translation for Probability Modeling of Binary Scalar Mixing in Turbulent Flows I R. S. MILLER , S. H

Nanofractography of Composition B Fracture Surfaces With AFM

DTIC Science & Technology

2004-12-01

structures (Miller and Garroway , 2001). Also, the monoclinic form(s), mostly assumed to be the ones present at low temperature, are known to exhibit...parameters of ~ 0.6, ~ 1.5, and ~ 2.0 - 2.1 nm lengths. No identification of potential cleavage planes are given in Miller and Garroway (Miller...and Garroway , 2001). TNT is known to be relatively ductile compared to the other listed energetic materials and shear deformation before fracture is

FinFET-based Miller encoder for UHF and SHF RFID application

NASA Astrophysics Data System (ADS)

Srinivasulu, Avireni; Sravanthi, G.; Sarada, M.; Pal, Dipankar

2018-01-01

This paper proposes a T-flip-flop and a Miller encoder design for ultra-high frequency and super high frequency, radio-frequency identification (RFID) application using FinFETs. Miller encoder is used in magnetic recording, in optical domain and also in RFID. Performance of the proposed circuit was examined by installing the model parameters of 20-nm FinFET (obtained from open source) on Cadence platform with +0.4 V supply rail at frequencies of 1, 2 and 10 GHz. Simulation results have confirmed that proposed Miller encoder offers a simpler design with reduced transistor count and gives lower power dissipation, higher frequency range of operation at lower supply rail as compared to other candidate designs. Proposed design also promises less propagation delay.

Pairing Relationships Among Feldspathic Lunar Meteorites from Miller Range, Antarctica

NASA Technical Reports Server (NTRS)

Zeigler, Ryan A.; Korotev, R. L.; Jolliff, B. L.

2012-01-01

The Miller Range ice fields have been amongst the most prolific for lunar meteorites that ANSMET has searched [1-3]. Six different stones have been recovered during the 2005, 2007, and 2009 field seasons: MIL 05035 (142 g), MIL 07006 (1.4 g), MIL 090034 (196 g), MIL 090036 (245 g), MIL 090070 (137 g), and MIL 090075 (144 g). Of these, the five stones collected during the 2007 and 2009 seasons are feldspathic breccias. Previous work on the Miller Range feldspathic lunar meteorites (FLMs) has suggested that they are not all paired with each other [4-5]. Here we examine the pairing relationships among the Miller Range FLMs using petrography in concert with traceand major-element compositions.

Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes

PubMed Central

Oegema, Renske; Cushion, Thomas D.; Phelps, Ian G.; Chung, Seo-Kyung; Dempsey, Jennifer C.; Collins, Sarah; Mullins, Jonathan G.L.; Dudding, Tracy; Gill, Harinder; Green, Andrew J.; Dobyns, William B.; Ishak, Gisele E.; Rees, Mark I.; Doherty, Dan

2015-01-01

Mutations in alpha- and beta-tubulins are increasingly recognized as a major cause of malformations of cortical development (MCD), typically lissencephaly, pachygyria and polymicrogyria; however, sequencing tubulin genes in large cohorts of MCD patients has detected tubulin mutations in only 1–13%. We identified patients with a highly characteristic cerebellar dysplasia but without lissencephaly, pachygyria and polymicrogyria typically associated with tubulin mutations. Remarkably, in seven of nine patients (78%), targeted sequencing revealed mutations in three different tubulin genes (TUBA1A, TUBB2B and TUBB3), occurring de novo or inherited from a mosaic parent. Careful re-review of the cortical phenotype on brain imaging revealed only an irregular pattern of gyri and sulci, for which we propose the term tubulinopathy-related dysgyria. Basal ganglia (100%) and brainstem dysplasia (80%) were common features. On the basis of in silico structural predictions, the mutations affect amino acids in diverse regions of the alpha-/beta-tubulin heterodimer, including the nucleotide binding pocket. Cell-based assays of tubulin dynamics reveal various effects of the mutations on incorporation into microtubules: TUBB3 p.Glu288Lys and p.Pro357Leu do not incorporate into microtubules at all, whereas TUBB2B p.Gly13Ala shows reduced incorporation and TUBA1A p.Arg214His incorporates fully, but at a slower rate than wild-type. The broad range of effects on microtubule incorporation is at odds with the highly stereotypical clinical phenotype, supporting differential roles for the three tubulin genes involved. Identifying this highly characteristic phenotype is important due to the low recurrence risk compared with the other (recessive) cerebellar dysplasias and the apparent lack of non-neurological medical issues. PMID:26130693

Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.

PubMed

Inoue, Takashi; Ogawa, Masaharu; Mikoshiba, Katsuhiko; Aruga, Jun

2008-04-30

The formation of the highly organized cortical structure depends on the production and correct placement of the appropriate number and types of neurons. The Zic family of zinc-finger transcription factors plays essential roles in regulating the proliferation and differentiation of neuronal progenitors in the medial forebrain and the cerebellum. Examination of the expression of Zic genes demonstrated that Zic1, Zic2, and Zic3 were expressed by the progenitor cells in the septum and cortical hem, the sites of generation of the Cajal-Retzius (CR) cells. Immunohistochemical studies have revealed that Zic proteins were abundantly expressed in the meningeal cells and that the majority of the CR cells distributed in the medial and dorsal cortex also expressed Zic proteins in the mid-late embryonic and postnatal cortical marginal zones. During embryonic cortical development, Zic1/Zic3 double-mutant and hypomorphic Zic2 mutant mice showed a reduction in the number of CR cells in the rostral cortex, whereas the cell number remained unaffected in the caudal cortex. These mutants also showed mislocalization of the CR cells and cortical lamination defects, resembling the changes noted in type II (cobblestone) lissencephaly, throughout the brain. In the Zic1/3 mutant, reduced proliferation of the meningeal cells was observed before the thinner and disrupted organization of the pial basement membrane (BM) with reduced expression of the BM components and the meningeal cell-derived secretory factor. These defects correlated with the changes in the end feet morphology of the radial glial cells. These findings indicate that the Zic genes play critical roles in cortical development through regulating the proliferation of meningeal cells and the pial BM assembly.

Gridded Surface Subsurface Hydrologic Analysis Modeling for Analysis of Flood Design Features at the Picayune Strand Restoration Project

DTIC Science & Technology

2016-08-01

the POI. ............................................................... 17  Figure 9. Discharge time series for the Miller pump system...2. In C2, the Miller Canal pump system was implicitly simulated by a time series of outflows assigned to model cells. This flow time series was...representative of how the pump system would operate during the storm events simulated in this work (USACE 2004). The outflow time series for the Miller

The Utilization of Starute Decelerators for Improved Upper Atmosphere Measurements

DTIC Science & Technology

1974-12-01

34 ECOM-5489, May 1973. 17. Miller, Walter B., and Donald R. Veazey , "An Integrated Error Description of Active and Passive Balloon Tracking Systems," ECOM...20. Miller, Walter B., and Donald R. Veazey , "Vertical Efficiency of Active and Passive Balloon Tracking Systems from a Standpoint of Integrated Error...5542, May 1974. 60. Miller, Walter B., and Donald R. Veazey , "On Increasing Vertical Efficiency of a Passive Balloon Tracking Device by Optimal Choice

TALON: a universal unmanned ground vehicle platform, enabling the mission to be the focus

NASA Astrophysics Data System (ADS)

Wells, Peter; Deguire, Dan

2005-05-01

Foster-Miller's unmanned ground vehicle, TALON, was originally developed under DARPA's Tactical Mobile Robotics (TMR) program. TALON has evolved over the years and has proven to be a robust, mobile, universal platform. As a result of the advances made in the evolution of TALON, new and far-reaching opportunities have been realized for unmanned ground vehicles. In recent conflicts such as in Afghanistan and Iraq, unmanned systems have played an important role and have extended the reach and capabilities of the War fighter. Technological advances have transformed unmanned vehicles in to useful tools and in some cases are used in lieu of sending in a soldier. Unmanned ground vehicles have seen recent and persistent success, as shown in theater, in the explosive ordinance disposal (EOD) and improvised ordinance disposal (IED) missions. Foster-Miller's TALON has experienced over ten thousand EOD and IED missions in Iraq alone. The success of the unmanned system has resulted in the doctrine "Send the robot in first". Foster-Miller has taken the role of the unmanned vehicle in yet another direction. Foster-Miller has transformed the TALON from a "practical" to "tactical" system. Through the combined efforts of Foster-Miller and the US Army, TALON has been involved in a weaponization program. To date, Foster-Miller has outfitted the TALON with 11 systems. As one can see, the unmanned ground vehicle is much more than a mobility platform.

Anatomical frame plate osteosynthesis in Ada-Miller Type 2 or 4 scapula fractures.

PubMed

Esenkaya, İrfan; Ünay, Koray

2011-01-01

The aim of this prospective study was to evaluate the results of anatomical frame plate osteosynthesis in patients with Ada and Miller Type 2 or 4 scapula fractures. Eleven Ada and Miller Type 2 or 4 scapula fractures in nine patients were treated with anatomical frame plate osteosynthesis. The mean follow-up time was 39.8 (12-77) months. The results were evaluated using the Herscovici score. No complications, such as neurovascular injury, postoperative hematoma, infection, delayed wound healing, implant failure, delayed union, or nonunion occurred. Based on the Herscovici score, the results were excellent. Osteosynthesis with anatomical frame plates appears to be a safe method that allows early range of motion and that provides excellent results in Ada and Miller Type 2 or 4 scapula fractures.

01-NIF Dedication: George Miller

ScienceCinema

George Miller

2017-12-09

The National Ignition Facility, the world's largest laser system, was dedicated at a ceremony on May 29, 2009 at Lawrence Livermore National Laboratory. These are the remarks by Lab Director George Miller.

01-NIF Dedication: George Miller

DOE Office of Scientific and Technical Information (OSTI.GOV)

George Miller

2009-07-02

The National Ignition Facility, the world's largest laser system, was dedicated at a ceremony on May 29, 2009 at Lawrence Livermore National Laboratory. These are the remarks by Lab Director George Miller.

Implications of Societal Fragmentation for State Formation: Can Democracy Succeed in Afghanistan

DTIC Science & Technology

2006-03-01

Conflict,” in Nationalism and Ethnic Conflict, Eds. Michael E. Brown, Owen R. Cote Jr., Sean M . Lynn-Jones, and Steven E. Miller (Cambridge and London: The...Cote Jr., Sean M . Lynn-Jones, and Steven E. Miller (Cambridge and London: The MIT Press, 1997), 49. 21 conceptions of legitimacy, they are...and Ethnic Conflict, Eds. Michael E. Brown, Owen R. Cote Jr., Sean M . Lynn-Jones, and Steven E. Miller (Cambridge and London: The MIT Press, 1997

Chemistry and Physics of Weakly Ionized Plasmas

DTIC Science & Technology

2010-01-22

temperature: Stabilization of the reactant intermediate A.A. Viggiano, Thomas . M. Miller, Skip Williams, S.T. Arnold, J.V. Seeley , and J.F. Friedman J...16. A Theoretical Study of High Electron Affinity Sulfur Oxyfluorides FSO3, F3SO2, and F5SO Susan T. Arnold, Thomas M. Miller, and A.A. Viggiano...McSweeney, M. D. Hargus, D. M Kerr, Thomas M. Miller, and A. A. Viggiano Int. J. Mass Spectrom. 228, 541-549 (Aug 2003). 37. Reactions and

United States Air Force Summer Faculty Research Program 1989. Program Technical Report. Volume 1

DTIC Science & Technology

1989-12-01

Amy Miller Transition-Metal Compounds ; Reactions of Iron and Iron Carbonyl Anions 59 Acidities of Iron Hydride and Various Dr. Thomas Miller...Transition-Metal Compounds ; Reactions of Iron and Iron Carbonyl Anions (Same Report as Dr. Amy Miller) 60 C02(4.3pm) Vibrational Temperatures and Dr. Henry...Release. Table VIII gives data on the the two alloy systems, Pd/Al and Ni/Al. It also gives some properties of the compound , Pd/Hz. A brief description of

Metals Subcommittee Report - Manufacturing Technology Advisory Group.

DTIC Science & Technology

1980-01-01

Electric Co, Mr. K. W. Stalker Abex Corp, Mr. W. R. Matschulat TRW Equipment, Mr. John McCarthy General Electric Co, Mr. A. I. Bellin General Electric...Code 6721C Philadelphia, PA 19112 Philadelphia, PA 19112 AV 443-3991, 215-755-3991 AV 443-3285, 215-755-3285 Mr. Howard Miller Mr. Joseph Glatz NAVAIR...DRXIB-MT 793-6586 John Melonas DRSMI-EAM 746-1902 GiovanAi Silvestri NUSC Newport 948-2617 Fred Miller AFML/LTM 785-5037 Howard Miller NAVAIR AIR-5162

Materials Science and Engineering-1989 Publications (Naval Research Laboratory)

DTIC Science & Technology

1991-03-29

34 D.G. Cory, J.B. Miller, A.N. Garroway "Acousto-Optic and Linear Electro-Optic Journal of Magnetic Resonance, 85, 219 Properties of Organic Polymeric...34Demonstration of Indirect Detection of ൕC Refocused Gradient Imaging of Solids" 14N Overtone NMR Transitions" J.B. Miller, A.N. Garroway A.N. Garroway , J.B...Conductive Polymer Solids" Chemical Vapor Sensors" J.B. Miller, A.N. Garroway J.F. Giuiani, T.M. Keller Journal of Magnetic Resonance, 85, 255 Journal of

The 14th Hoyt Lecture: Ischemic Optic Neuropathy: The Evolving Profile, 1966-2015.

PubMed

Arnold, Anthony C

2016-06-01

Since the first English language description by Miller and Smith in 1966 of ischemic optic neuropathy as a distinct ophthalmic syndrome, a long series of studies has refined the clinical profile to what we consider to be accurate today. From the specifics of pathogenesis to the clinical appearance to the effect of therapy, the basic tenets of diagnosis and management have evolved over 5 decades. What we thought we knew about the following topics has changed: location of vasculopathy; incidence; age at onset; optic disc appearance; risk factors for development; natural history; rate of fellow eye involvement; ischemia as an all-or-none phenomenon; and treatment. A look back at these discoveries shows both how far we have come and how far we have to go in managing this disorder.

Source identification and fish exposure for polychlorinated biphenyls using congener analysis from passive water samplers in the Millers River basin, Massachusetts

USGS Publications Warehouse

Colman, John A.

2001-01-01

Measurements of elevated concentrations of polychlorinated biphenyls (PCBs) in fish and in streambed sediments of the Millers River Basin, Massachusetts and New Hampshire, have been reported without evidence of the PCB source. In 1999, an investigation was initiated to determine the source(s) of the elevated PCB concentrations observed in fish and to establish the extent of fish exposure to PCBs along the entire main stems of the Millers River and one of its tributaries, the Otter River. Passive samplers deployed for 2-week intervals in the water-column at 3 1 stations, during summer and fall 1999, were used to assess PCB concentrations in the Millers River Basin. The samplers concentrate PCBs, which diffuse from the water column through a polyethylene membrane to hexane (0.200 liters) contained inside the samplers. Only dissolved PCBs (likely equivalent to the bioavailable fraction) are subject to diffusion through the membrane. The summed concentrations of all targeted PCB congeners (summed PCB) retrieved from the samplers ranged from 1 to 8,000 nanograms per hexane sample. Concentration and congener-pattern comparisons indicated that the historical release of PCBs in the Millers River Basin likely occurred on the Otter River at the upstream margin of Baldwinville, Mass. Elevated water-column concentrations measured in a wetland reach on the Otter River downstream from Baldwinville were compatible with a conceptual model for a present-day (1999) source in streambed sediments, to which the PCBs partitioned after their original introduction into the Otter River and from which PCBs are released to the water now that the original discharge has ceased or greatly decreased. Two four-fold decreases in summed PCB concentrations in the Millers River, by comparison with the highest concentration on the Otter River, likely were caused by (1) dilution with water from the relatively uncontaminated upstream Millers River and (2) volatilization of PCBs from the Millers River in steep-gradient reaches. A relatively constant concentration of summed PCBs in the reach of the Millers River from river mile 20 to river mile 10 was likely a consequence of a balance between decreased volatilization rates in that relatively low-gradient reach and resupply of PCBs to the water column from contaminated streambed sediments. A second high-gradient reach from river mile 10 to the confluence of the Millers River with the Connecticut River also was associated with a decrease in concentration of water-column summed PCBs. Volatilization as a loss mechanism was supported by evidence in the form of slight changes of the congener pattern in the reaches where decreases occurred. Exposure of fish food webs to concentrations of dissolved PCBs exceeded the U.S. Environmental Protection Agency's water-quality criterion for PCBs throughout most of the Millers River and Otter River main stems. Because the apparent source of PCBs discharged was upstream on the Otter River, a large number of river miles downstream (more than 30 mi) had summer water-column PCB concentrations that would likely lead to high concentrations of PCBs in fish.

Early electrophysiological findings in Fisher-Bickerstaff syndrome.

PubMed

Alberti, M A; Povedano, M; Montero, J; Casasnovas, C

2017-09-06

The term Fisher-Bickerstaff syndrome (FBS) has been proposed to describe the clinical spectrum encompassing Miller-Fisher syndrome (MFS) and Bickerstaff brainstem encephalitis. The pathophysiology of FBS and the nature of the underlying neuropathy (demyelinating or axonal) are still subject to debate. This study describes the main findings of an early neurophysiological study on 12 patients diagnosed with FBS. Retrospective evaluation of clinical characteristics and electrophysiological findings of 12 patients with FBS seen in our neurology department within 10 days of disease onset. Follow-up electrophysiological studies were also evaluated, where available. The most frequent electrophysiological finding, present in 5 (42%) patients, was reduced sensory nerve action potential (SNAP) amplitude in one or more nerves. Abnormalities were rarely found in motor neurography, with no signs of demyelination. The cranial nerve exam revealed abnormalities in 3 patients (facial neurography and/or blink reflex test). Three patients showed resolution of SNAP amplitude reduction in serial neurophysiological studies, suggesting the presence of reversible sensory nerve conduction block. Results from cranial MRI scans were normal in all patients. An electrophysiological pattern of sensory axonal neuropathy, with no associated signs of demyelination, is an early finding of FBS. Early neurophysiological evaluation and follow-up are essential for diagnosing patients with FBS. Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Primordial soup was edible: abiotically produced Miller-Urey mixture supports bacterial growth.

PubMed

Xie, Xueshu; Backman, Daniel; Lebedev, Albert T; Artaev, Viatcheslav B; Jiang, Liying; Ilag, Leopold L; Zubarev, Roman A

2015-09-28

Sixty years after the seminal Miller-Urey experiment that abiotically produced a mixture of racemized amino acids, we provide a definite proof that this primordial soup, when properly cooked, was edible for primitive organisms. Direct admixture of even small amounts of Miller-Urey mixture strongly inhibits E. coli bacteria growth due to the toxicity of abundant components, such as cyanides. However, these toxic compounds are both volatile and extremely reactive, while bacteria are highly capable of adaptation. Consequently, after bacterial adaptation to a mixture of the two most abundant abiotic amino acids, glycine and racemized alanine, dried and reconstituted MU soup was found to support bacterial growth and even accelerate it compared to a simple mixture of the two amino acids. Therefore, primordial Miller-Urey soup was perfectly suitable as a growth media for early life forms.

1. Historic American Buildings Survey Wells Fargo Bank Historical Museum ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey Wells Fargo Bank Historical Museum Original: About 1934 Re- photo: August, 1940 FORD FOR TEAM CROSSING - Fort Miller Ford, Lake Millerton, Fort Miller (historical), Madera County, CA

Polymyositis: Can a Gluten-Free Diet Reduce Symptoms?

MedlinePlus

... Can polymyositis affect my lungs? Answers from April Chang-Miller, M.D. Polymyositis (pol-e-my-o- ... are easy to chew and swallow With April Chang-Miller, M.D. Polymyositis information page. National Institute ...

Genetics Home Reference: SYNGAP1-related intellectual disability

MedlinePlus

... TK, Ozkan ED, Shi Y, Reish NJ, Almonte AG, Miller BH, Wiltgen BJ, Miller CA, Xu X, ... qualified healthcare professional . About Selection Criteria for Links Data Files & API Site Map Subscribe Customer Support USA. ...

The 1953 Stanley L. Miller Experiment: Fifty Years of Prebiotic Organic Chemistry

NASA Technical Reports Server (NTRS)

Lazcano, Antonio; Bada, Jeffrey L.

2003-01-01

The field of prebiotic chemistry effectively began with a publication in Science 50 years ago by Stanley L. Miller on the spark discharge synthesis of amino acids and other compounds using a mixture of reduced gases that were thought to represent the components of the atmosphere on the primitive Earth. On the anniversary of this landmark publication, we provide here an accounting of the events leading to the publication of the paper. We also discuss the historical aspects that lead up to the landmark Miller experiment.

NMR Studies of Organic Thin Films

DTIC Science & Technology

1994-02-28

C.G. Chingas, J.B. Miller, and A.N. Garroway , J. Magn. Reson., 1986, 66, 530. 126. D.G. Cory, J.W.M. van Os, and W.S. Veeman, J. Magn. Reson., 1988, 76...Zumbulyadis and J.M. O’Reilly, J. Magn. Reson., 1989, 82, 613. 131. H.A. Resing, A.N. Garroway , D.C. Weber, J. Ferraris, and D. Slotfeldt-Ellingsen, Pure...Natansohn, Polym. Eng. Sci., 1992, 32, 1711. 137. J.B. Miller and A.N. Garroway , J. Magn. Reson., 1989, 82, 529. 138. D.G. Cory, J.B. Miller, R. Turner

Minimizing shrinkage of interdental papilla height when treating multiple Miller Class III gingival recession defects.

PubMed

Mahn, Douglas H

2015-04-01

Miller Class III and IV gingival recession defects have interdental bone and soft-tissue loss that limit root coverage. Given the importance of the interdental papilla, protecting the integrity of this structure would seem prudent. Tunnel techniques have been successfully used to protect the interdental papilla. This article discusses the results of two cases in which multiple Miller Class III gingival recession defects were treated using tunnel-grafting techniques and an acellular dermal matrix. In both cases, root coverage was achieved while protecting the interdental papilla height.

NREL Research Pinpoints Promise of Polycrystalline Perovskites | News |

Science.gov Websites

Beard, David Moore and Elisa Miller are co-authors of a new paper in Nature Energy about perovskites , Yong Yan, Elisa M. Miller, and Kai Zhu. Beard said the research determined surface recombination

Conducting Miller-Urey Experiments

NASA Technical Reports Server (NTRS)

Parker, Eric Thomas; Cleaves, Henderson James; Burton, Aaron S.; Glavin, Daniel P.; Dworkin, Jason; Zhou, Manshui; Bada, Jeffrey L.; Fernandez, Facundo M.

2014-01-01

In 1953, Stanley Miller reported the production of biomolecules from simple gaseous starting materials, using apparatus constructed to simulate the primordial Earth's atmosphere-ocean system. Miller introduced 200 ml of water, 100 mmHg of H2, 200mmHg of CH4, and 200mmHg of NH3 into the apparatus, then subjected this mixture, under reflux, to an electric discharge for a week, while the water was simultaneously heated. The purpose of this manuscript is to provide the reader with a general experimental protocol that can be used to conduct a Miller-Urey type spark discharge experiment, using a simplified 3 L reaction flask. Since the experiment involves exposing inflammable gases to a high voltage discharge, it is worth highlighting important steps that reduce the risk of explosion. The general procedures described in this work can be extrapolated to design and conduct a wide variety of electric discharge experiments simulating primitive planetary environments.

George Miller's magical number of immediate memory in retrospect: Observations on the faltering progression of science.

PubMed

Cowan, Nelson

2015-07-01

Miller's (1956) article about storage capacity limits, "The Magical Number Seven Plus or Minus Two . . .," is one of the best-known articles in psychology. Though influential in several ways, for about 40 years it was oddly followed by rather little research on the numerical limit of capacity in working memory, or on the relation between 3 potentially related phenomena that Miller described. Given that the article was written in a humorous tone and was framed around a tongue-in-cheek premise (persecution by an integer), I argue that it may have inadvertently stymied progress on these topics as researchers attempted to avoid ridicule. This commentary relates some correspondence with Miller on his article and concludes with a call to avoid self-censorship of our less conventional ideas. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

Symmetrical windowing for quantum states in quasi-classical trajectory simulations: Application to electron transfer

NASA Astrophysics Data System (ADS)

Cotton, Stephen J.; Igumenshchev, Kirill; Miller, William H.

2014-08-01

It has recently been shown [S. J. Cotton and W. H. Miller, J. Chem. Phys. 139, 234112 (2013)] that a symmetrical windowing quasi-classical (SQC) approach [S. J. Cotton and W. H. Miller, J. Phys. Chem. A 117, 7190 (2013)] applied to the Meyer-Miller model [H.-D. Meyer and W. H. Miller, J. Chem. Phys. 70, 3214 (1979)] for the electronic degrees of freedom in electronically non-adiabatic dynamics is capable of quantitatively reproducing quantum mechanical results for a variety of test applications, including cases where "quantum" coherence effects are significant. Here we apply this same SQC methodology, within a flux-side correlation function framework, to calculate thermal rate constants corresponding to several proposed models of electron transfer processes [P. Huo, T. F. Miller III, and D. F. Coker, J. Chem. Phys. 139, 151103 (2013); A. R. Menzeleev, N. Ananth, and T. F. Miller III, J. Chem. Phys. 135, 074106 (2011)]. Good quantitative agreement with Marcus Theory is obtained over several orders of magnitude variation in non-adiabatic coupling. Moreover, the "inverted regime" in thermal rate constants (with increasing bias) known from Marcus Theory is also reproduced with good accuracy by this very simple classical approach. The SQC treatment is also applied to a recent model of photoinduced proton coupled electron transfer [C. Venkataraman, A. V. Soudackov, and S. Hammes-Schiffer, J. Chem. Phys. 131, 154502 (2009)] and population decay of the photoexcited donor state is found to be in reasonable agreement with results calculated via reduced density matrix theory.

Symmetrical windowing for quantum states in quasi-classical trajectory simulations: Application to electron transfer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cotton, Stephen J.; Igumenshchev, Kirill; Miller, William H., E-mail: millerwh@berkeley.edu

It has recently been shown [S. J. Cotton and W. H. Miller, J. Chem. Phys. 139, 234112 (2013)] that a symmetrical windowing quasi-classical (SQC) approach [S. J. Cotton and W. H. Miller, J. Phys. Chem. A 117, 7190 (2013)] applied to the Meyer-Miller model [H.-D. Meyer and W. H. Miller, J. Chem. Phys. 70, 3214 (1979)] for the electronic degrees of freedom in electronically non-adiabatic dynamics is capable of quantitatively reproducing quantum mechanical results for a variety of test applications, including cases where “quantum” coherence effects are significant. Here we apply this same SQC methodology, within a flux-side correlation functionmore » framework, to calculate thermal rate constants corresponding to several proposed models of electron transfer processes [P. Huo, T. F. Miller III, and D. F. Coker, J. Chem. Phys. 139, 151103 (2013); A. R. Menzeleev, N. Ananth, and T. F. Miller III, J. Chem. Phys. 135, 074106 (2011)]. Good quantitative agreement with Marcus Theory is obtained over several orders of magnitude variation in non-adiabatic coupling. Moreover, the “inverted regime” in thermal rate constants (with increasing bias) known from Marcus Theory is also reproduced with good accuracy by this very simple classical approach. The SQC treatment is also applied to a recent model of photoinduced proton coupled electron transfer [C. Venkataraman, A. V. Soudackov, and S. Hammes-Schiffer, J. Chem. Phys. 131, 154502 (2009)] and population decay of the photoexcited donor state is found to be in reasonable agreement with results calculated via reduced density matrix theory.« less

Tangent to Experimental Techniques of Verbal Control.

ERIC Educational Resources Information Center

Bilodeau, Ina McD.

This paper is a critical comment and reaction to a 1965 article by G. A. Miller entitled "Some Preliminaries to Psycholinguistics." The subject matter is verbal control of behavior. Seven specific aspects of the Miller address are discussed. (WD)

Evaluation of the Efficacy, Potential for Vector Transmission, and Duration of Immunity of MP-12, an Attenuated Rift Valley Fever Virus Vaccine Candidate, in Sheep

DTIC Science & Technology

2015-08-01

testing by virus isolation (VI). Positive-control mosquitoes were sampled whole on the day of the spiked blood meal. b NA, not applicable. Miller et al ...percent inhibition of the negative control, calculated as 1 (test serum OD/negative serum OD) 100. Miller et al . 934 cvi.asm.org August 2015 Volume 22...Trop Med Hyg 44:278 –282. 34. Morrill JC, Mebus CA, Peters CJ. 1997. Safety of a mutagen-attenuated Miller et al . 936 cvi.asm.org August 2015 Volume 22

Dealing with innovation and costs in orthopedics: a conversation with Dane Miller. Interview by Lawton R Burns.

PubMed

Miller, Dane

2006-01-01

Rob Burns talks with Dane Miller, former CEO of Biomet, about challenges posed by new technology in the orthopedic devices area. One key challenge is the rising cost and use of orthopedic devices at a time when providers are facing decreased profitability and reimbursement for orthopedic services. Another challenge is the long-term time horizon needed to gauge product success that contrasts with payers' and providers' short-term horizon. A third challenge is heightened governmental scrutiny of device makers' relationships with orthopedic surgeons. This interview was conducted before Miller left Biomet in March 2006.

New Insights into Prebiotic Chemistry from Old Archived Miller Extracts

NASA Technical Reports Server (NTRS)

Parker, Eric T.; Cleaves, H. James; Dworkin, Jason P.; Glavin, Daniel P.; Callahan, Michael P.; Aubrey, Andrew D.; Lazcano, Antonio; Bada, Jeffrey L.

2011-01-01

Following the discovery of an archived set of samples from Stanley Miller's early experiments, analyses were undertaken to better understand the diversity of compounds produced from electric discharges acting on reducing gas mixtures. The paper chromatography methods that Miller used in the 1950s were only capable of detecting a few amino acids and were unable to provide substantial quantitative data relative to today's techniques. Current analytical techniques are much more sensitive and selective, and are capable of precisely quantifying a much larger range of amino acids and their enantiomeric abundances. In one study, preserved dried samples produced by Miller using a lesser-known volcanic apparatus which differed from Miller's classic apparatus in that it utilized an aspirator that injected steam into the electric discharge chamber, simulating a volcanic eruption. The volcanic apparatus produced a wider variety of amino acids than the classic configuration. Prebiotic compounds synthesized in these environments may have locally accumulated where they could have undergone further processing. An additional preserved set of samples from an experiment conducted in 1958 were also found in Miller's archived collection. These samples which had been generated using a mixture of CH4, NH3, H2S and CO2 were collected, catalogued, and stored by Miller, but for unknown reasons were never studied. In our analyses a total of 23 amino acids and 4 amines, including 7 organosulfur compounds, were detected in these samples. The major amino acids with chiral centers are racemic within the accuracy of the measurements, indicating that they are not contaminants introduced during sample storage. This experiment marks the first synthesis of sulfur amino acids from spark discharge experiments designed to imitate primordial environments. The relative yield of some amino acids, in particular the isomers of amino butyric acid, are the highest ever found in a spark discharge experiment. The simulated primordial conditions used by Miller in these experiments may serve as a model for early volcanic plume chemistry and provide insight to the possible roles such plumes may have played in abiotic organic synthesis. Additionally, the overall abundances of the synthesized amino acids in the presence of H2S are very similar to the abundances found in some carbonaceous meteorites, suggesting that H2S may have played an important role in prebiotic reactions in early solar system environments. Although experiments using a variety of gases as components of the primordial Earth's atmospheric composition and a spark discharge apparatus configured according to Miller's original or volcanic design can be readily carried out, the unique opportunity to investigate samples prepared by the pioneer in abiotic synthesis using state of the art analytical methods is of considerable historic interest.

[Macro- and microscopic systematization of cerebral cortex malformations in children].

PubMed

Milovanov, A P; Milovanova, O A

2011-01-01

For the first time in pediatric pathologicoanatomic practice the complete systematization of cerebral cortex malformations is represented. Organ, macroscopic forms: microencephaly, macroencephaly, micropolygyria, pachygyria, schizencephaly, porencephaly, lissencephaly. Histic microdysgenesis of cortex: type I includes isolated abnormalities such as radial (IA) and tangential (I B) subtypes of cortical dislamination; type II includes sublocal cortical dislamination with immature dysmorphic neurons (II A) and balloon cells (II B); type III are the combination focal cortical dysplasia with tuberous sclerosis of the hippocampus (III A), tumors (III B) and malformations of vessels, traumatic and hypoxic disorders (III C). Band heterotopias. Subependimal nodular heterotopias. Tuberous sclerosis. Cellular typification of cortical dysplasia: immature neurons and balloon cells.

Lunar Meteorites Miller Range 090034, 090070 and 090075: Composition and Pairing

NASA Astrophysics Data System (ADS)

Martin, D. J. P.; Joy, K. H.

2014-09-01

Three Miller Range meteorites (MIL 34, MIL 70 and MIL 75) were analysed for their compositions and textures. Similarities indicate they are launch paired. Also, they are comparable to Apollo FAN samples so may originate from the lunar nearside.

West 73rd Street pedestrian underpass, with spur of old Miller ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

West 73rd Street pedestrian underpass, with spur of old Miller Highway, Trump Place towers in background, looking south. - Henry Hudson Parkway, Extending 11.2 miles from West 72nd Street to Bronx-Westchester border, New York County, NY

Disequilibrium: An Instructional Coach's Reflection

ERIC Educational Resources Information Center

Butler, Melinda S.; Votteler, Nancy K.

2016-01-01

When Debbie Miller, educational consultant and author of "Reading with Meaning" (2013) and "Teaching with Intention" (2008) visited a Title I elementary school in Texas, the instructional reading coach was challenged in her thinking about best practices for independent reading. Ms. Miller's visit included modeling interactive…

Carnivorous diving beetles of the genus Desmopachria (Coleoptera: Dytiscidae) from Brazil: New species, new records, and a checklist

PubMed Central

Braga, Rafael Benzi; Ferreira, Nelson

2014-01-01

Abstract Eight new species of DesmopachriaBabington, 1841 are described and illustrated from Brazil: D. dicrophallica sp. nov. , D. disticta sp. nov. , D. grammosticta sp. nov. , D . grandinigra sp. nov. , D. itamontensis sp. nov. , D. leptophallica sp. nov. , D. stethothrix sp. nov. , and D. ukuki sp. nov. The species D. amyaeMiller, 2001 , D. cheiMiller, 1999 , D. margarita Young, 1990, and D. volatidiscaMiller, 2001 are recorded for the first time from Brazil. From species of the Desmopachria reported in Brazil, D. aldessaYoung, 1980 has a new record from Pará state and D. fossulataZimmermann, 1928, D. granoidesYoung, 1986 , and D. laevis Sharp, 1882 have new records from Rio de Janeiro State. A checklist of all Desmopachria recorded from Brazil is presented with notes about some of the localities. Resumo Oito espécies novas de DesmopachriaBabington, 1841 são descritas e ilustradas para o Brasil, D. dicrophallica sp. nov. , D. disticta sp. nov. , D. grammosticta sp. nov. , D . grandinigra sp. nov., D. itamontensis sp. nov., D. leptophallica sp. nov., D. stethothrix sp. nov. e D. ukuki sp. nov. As espécies D. amyaeMiller, 2001, D. cheiMiller, 1999 , D. margarita Young, 1990 e D. volatidiscaMiller, 2001 são registradas pela primeira vez para o Brasil. Das espécies de Desmopachria registradas para o Brasil D. aldessaYoung, 1980 tem um novo registro para o estado do Pará e D. fossulataZimmermann, 1928 , D. granoidesYoung, 1986 e D. laevis Sharp, 1882 têm novos registros para o estado do Rio de Janeiro. Uma listagem de todos os Desmopachria registrados para o Brasil é apresentada, com notas acerca de algumas localidades. PMID:25373202

Development in the Workplace.

ERIC Educational Resources Information Center

Demick, Jack, Ed.; Miller, Patrice M., Ed.

This book contains edited versions of papers from a symposium on adult development and a final integrative chapter. The following papers are included: "Introduction" (Jack Demick, Patrice Miller); "Influences of World View on Personality, Epistemology, and Choice of Profession" (Melvin Miller, Alan West); "Developmental Conceptions of Good Work: A…

A Simplified Decision Support Approach for Evaluating Wetlands Ecosystem Services

EPA Science Inventory

We will be presenting a simplified approach to evaluating ecosystem services provided by freshwater wetlands restoration. Our approach is based on an existing functional assessment approach developed by Golet and Miller for the State of Rhode Island, and modified by Miller for ap...

28 CFR 79.51 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Cor pulmonale means heart disease, including hypertrophy of the right ventricle, due to pulmonary... Criteria for Claims by Uranium Millers § 79.51 Definitions. (a) Chronic renal disease means the chronic... or functional damage to the kidney tubules that results in renal disease and dysfunction. (g) Miller...

28 CFR 79.51 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Cor pulmonale means heart disease, including hypertrophy of the right ventricle, due to pulmonary... Criteria for Claims by Uranium Millers § 79.51 Definitions. (a) Chronic renal disease means the chronic... or functional damage to the kidney tubules that results in renal disease and dysfunction. (g) Miller...

Pharmacy profile. New ASCP president Robert J. Miller: entrepreneur who puts the patient first.

PubMed

Meade, Vicki

2005-10-01

Bob Miller, known for his enthusiasm and desire to nurture others' growth, brings to his term as 2005-2006 ASCP president the leadership skills and business acumen he developed over two decades as a long-term care pharmacy owner.

Guillain-Barré Syndrome, variants & forms fruste: Reclassification with new criteria.

PubMed

Hiew, Fu Liong; Ramlan, Rahmansah; Viswanathan, Shanthi; Puvanarajah, Santhi

2017-07-01

This study aimed to evaluate the clinical and electrophysiological characteristics of various distinctive classical and localised Guillain-Barré syndrome (GBS) subtypes. Clinical characteristics and electrophysiological data of sixty-one consecutive patients admitted between 2012 and 2015 were systematically analysed and reclassified according to the new GBS clinical classification. Neurophysiology was evaluated with Hadden et al.'s vs recently proposed Rajabally et al.'s criteria. Functional severity and clinical outcome of various GBS subtypes were ascertained. All patients initially identified as GBS or related disorders can be sub-classified into having classical GBS (41, 67%), classic Miller-Fisher Syndrome (MFS) (6, 10%), Pharyngeal-cervical-brachial (PCB) (3, 5%), paraparetic GBS (4, 7%), bifacial weakness with paresthesia (3, 5%), acute ophthalmoparesis (AO) (1, 2%) and overlap syndrome (3, 5%): one (2%) with GBS/Bickerstaff brainstem encephalitis overlap and 2 (3%) with GBS/MFS overlap. Greater proportion of axonal classical GBS (67% vs 55%, p=0.372) seen with Rajabally et al.'s criteria and a predominantly axonal form of paraparetic variant (75%) independent of electrodiagnostic criteria were more representative of Asian GBS cohort. Classical GBS patients had lowest admission and discharge Medical Research Council Sum Score (MRCSS), greater functional disability and longest length of in-patient stay. Twenty (20/21, 95%) patients who needed mechanical ventilation had classical GBS. Patients required repeated dose of intravenous immunoglobulin (5/6, 3%) or plasma exchange (4/4, 100%) more frequently had axonal form of classical GBS. Phenotype recognition based on new GBS clinical classification, supported by electrodiagnostic study permits more precise clinical subtypes determination and outcome prognostication. Copyright © 2017 Elsevier B.V. All rights reserved.

Symmetrical windowing for quantum states in quasi-classical trajectory simulations: Application to electronically non-adiabatic processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cotton, Stephen J.; Miller, William H., E-mail: millerwh@berkeley.edu

A recently described symmetrical windowing methodology [S. J. Cotton and W. H. Miller, J. Phys. Chem. A 117, 7190 (2013)] for quasi-classical trajectory simulations is applied here to the Meyer-Miller [H.-D. Meyer and W. H. Miller, J. Chem. Phys. 70, 3214 (1979)] model for the electronic degrees of freedom in electronically non-adiabatic dynamics. Results generated using this classical approach are observed to be in very good agreement with accurate quantum mechanical results for a variety of test applications, including problems where coherence effects are significant such as the challenging asymmetric spin-boson system.

Large-Scale Operations Management Test of Use of the White Amur for Control of Problem Aquatic Plants. Report 4. Third Year Poststocking Results. Volume VI. The Water and Sediment Quality of Lake Conway, Florida.

DTIC Science & Technology

1983-01-01

RAI-RI247443 LARGE-SCALE OPERATIONS MANAGEMENT TEST OF USE OF THE i/i UNITE AMUR FOR CONTR.. (U) MILLER RND MILLER INC ORLANDO FL H D MILLER ET RL...LARGE-SCALE OPERATIONS MANAGEMENT TEST OF USE OF THE WHITE AMUR FOR CONTROL OF PROBLEM AQUATIC PLANTS Report 1: Baseline Studies Volume I...Boyd, J. 1983. "Large-Scale Operations Management Test of Use of the White Amur for Control of Problem Aquatic Plants; Report 4, Third Year Poststocking

76 FR 35007 - Notice of Issuance of Final Determination Concerning the Country of Origin of Certain Office Chairs

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-15

... learning environments. The merchandise at issue is the Herman Miller SAYL task chair and the SAYL side... exact size and shape requested by Herman Miller. The TPU mesh is placed in a custom-made machine, which...

KSC-2015-1027

NASA Image and Video Library

2015-01-06

CAPE CANAVERAL, Fla. -- During a visit to NASA's Kennedy Space Center in Florida, NASA Chief Technologist David Miller, left, tours laboratories inside the Swamp Works facility. At right, Dr. Ray Wheeler, a plant physiologist in the Engineering and Technology Directorate discusses a wastewater treatment experiment with Miller. Photo credit: NASA/Kim Shiflett

75 FR 81331 - Surety Companies Acceptable on Federal Bonds: Termination-Penn Millers Insurance Company

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-27

... DEPARTMENT OF THE TREASURY Fiscal Service Surety Companies Acceptable on Federal Bonds: Termination--Penn Millers Insurance Company AGENCY: Financial Management Service, Fiscal Service, Department... Certificate of Authority issued by the Treasury to the above-named company under 31 U.S.C. 9305 to qualify as...

Speaking Personally--with Gary Miller

ERIC Educational Resources Information Center

Cano, Leslie

2016-01-01

Gary Miller is the executive director emeritus of the Penn State World Campus. Prior to his retirement he served as associate vice president for outreach and executive director of continuing and distance education at The Pennsylvania State University. In 2004 he received the Mildred B. and Charles A. Wedemeyer Award, presented jointly by "The…

Lavandula angustifolia Miller: English lavender.

PubMed

Denner, Sallie Stoltz

2009-01-01

Folk and traditional therapeutic use of the essential oil of English lavender for pain, infection, relaxation, and sedation dates back centuries. Current research focusing on the inherent synergism of Lavandula angustifolia Miller demonstrates great potential for future applications. Today's investigations may provide the key to eradicating degenerative inflammatory disease, infectious disease, and carcinogenesis.

Summary of reported agriculture and irrigation water use in Miller County, Arkansas, 1991

USGS Publications Warehouse

Holland, T.W.; Manning, C.A.; Stafford, K.L.

1993-01-01

This report summarizes the 1991 water-use reporting through the Conservation District Office in Miller County, Arkansas. The number of withdrawal registrations for Miller County was 98 (62 groundwater and 36 surface water). Water withdrawals reported during the registration process total 0.06 Mgal/d (0.06 Mgal/d groundwater and none from surface water) for agriculture and 24.74 Mgal/d (5.44 Mgal/d groundwater and 19.30 Mgal/d surface water) for irrigation. The registration reports for 1991 indicate that this water was applied to 9,872 acres of land to irrigate rice, corn, soybeans, cotton, and sod as well as for the agricultural use of animal aquaculture.

76 FR 18747 - Teton Power Funding, LLC; Topsham Hydro Partners Limited Partnership; Topsham Hydroelectric...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-05

.... Topsham Hydro Partners Limited Partnership: Christine M. Miller, Brown Bear GP, LLC, c/o ArcLight Capital.... Miller, Brown Bear Power, LLC, c/o ArcLight Capital Partners, LLC, 200 Clarendon Street, 55th Floor.... Bose, Secretary, Federal Energy Regulatory Commission, 888 First Street, NE., Washington, DC 20426...

75 FR 60126 - Performance Review Board Members

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-29

... Daulaire Beverly W. Davis Jeffrey S. Davis L'Tonya J. Davis Lori E. Davis Diann Dawson Molly P. Dawson.... Miller Tamara L. Miller George G. Mills Jr. Samuel P. Mitchell Madeline Mocko John W. Molina John T... William D. Saunders David W. Sayen James V. Scanlon Donald L. Schneider Lawrence N. Self James D. Seligman...

7 CFR 301.89-16 - Compensation for grain storage facilities, flour millers, National Survey participants, and...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Compensation for grain storage facilities, flour... DOMESTIC QUARANTINE NOTICES Karnal Bunt § 301.89-16 Compensation for grain storage facilities, flour... the 1999-2000 and subsequent crop seasons. Owners of grain storage facilities, flour millers, and...

Hybrid weeds! Agent biotypes!: Montana's ever-evolving toadflax biological control soap opera

Treesearch

S. E. Sing; D. K. Weaver; S. M. Ward; J. Milan; C. L. Jorgensen; R. A. Progar; A. Gassmann; I. Tooevski

2013-01-01

An exotic toadflax stem mining weevil conventionally identified as Mecinus janthinus Germar has become widely established on Dalmatian toadflax [Linaria dalmatica (Linnaeus) Miller] in western North America, although agent density and control efficacy are highly variable across release sites (De Clerck-Floate & Miller, 2002; McClay & Hughes, 2007; Van Hezewijk...

The Miller Motivation Scale: A New Counselling and Research Tool.

ERIC Educational Resources Information Center

Miller, Harold J.

The Miller Motivation Scale is a 160-item computer scored scale. It was developed to measure quickly and easily and display the motivational profile of the client. It has eight subscales. Five subscales measure encouragement, self-fulfillment and social interest. They are called Creative, Innovative, Productive, Cooperative, and Power. Three…

Bias and uncertainty of δ13CO2 isotopic mixing models

Treesearch

Zachary E. Kayler; Lisa Ganio; Mark Hauck; Thomas G. Pypker; Elizabeth W. Sulzman; Alan C. Mix; Barbara J. Bond

2009-01-01

The goal of this study was to evaluate how factorial combinations of two mixing models and two regression approaches (Keeling-OLS, Miller—Tans-OLS, Keeling-GMR, Miller—Tans-GMR) compare in small [CO2] range versus large[CO2] range regimes, with different combinations of...

28 CFR 79.53 - Proof of employment as a miller.

Code of Federal Regulations, 2010 CFR

2010-07-01

... EXPOSURE COMPENSATION ACT Eligibility Criteria for Claims by Uranium Millers § 79.53 Proof of employment as... Service (PHS) in the course of any health studies of uranium workers during or including the period 1942-1990; (2) Records of a uranium worker census performed by the PHS at various times during the period...

Genre as Social Action: A Gaze into Phenomenology

ERIC Educational Resources Information Center

Russell, David R.

2015-01-01

This article explores David Russell's long-time fascination with Genre as Social Action and Charles Bazerman's idea of genre systems (1994), based on Miller's 1984 article. He explains that the great insight Miller had, in that article, was to bring Schutz's concept of typification, and with it the western European tradition of phenomenological…

ManiacDec2015_720p

NASA Image and Video Library

2015-12-02

David Miller Maniac Lecture, December 2, 2015 NASA Chief Technologist David Miller presented a Maniac lecture entitled "Defying Gravity and Overcoming Inertia: a Systems Perspective." Dave shared his journey from MIT to the Air Force to NASA, from teaching to research to service, defying gravity, and overcoming inertia to do so, which has been his lifelong goal.

Preliminary Geologic Map of the Little Piute Mountains, California; a Digital Database

USGS Publications Warehouse

Howard, Keith A.; Dennis, Michael L.; Karlstrom, Karl; Phelps, Geoffrey A.

1997-01-01

Introduction The Little Piute Mountains in the eastern Mojave Desert expose a series of folds and thrust faults involving metamorphosed Paleozoic strata (Miller and others, 1982; Stone and others, 1983). Detailed mapping of these structures was undertaken to help elucidate regional Mesozoic structural evolution. Earlier geologic maps were prepared by Cooksley (1960a,b,c,d, generalized by Bishop, 1964) and Stone and others (1983). Deformed and metamorphosed Paleozoic and Triassic rocks form a stratal succession that was originally deposited in shallow seas on the North American craton. Based on lithologic sequence the units are correlated with unmetamorphosed equivalents 200 km to the northeast in the Grand Canyon, Arizona, and 35-50 km to the west in the Marble, Ship, and Providence Mountains, California (Stone and others, 1983). The Paleozoic sequence rests nonconformably on a heterogeneous basement of polydeformed Early Proterozoic gneiss (Miller and others, 1982; Wooden and Miller, 1990). Triassic and older rocks were deformed, metamorphosed to staurolite or andalusite grade, and intruded concordantly at their base by Late Cretaceous granodiorite (Miller and others, 1982).

Preliminary Geologic Map of the the Little Piute Mountains, San Bernardino County, California

USGS Publications Warehouse

Howard, Keith A.; Dennis, Michael L.; Karlstrom, Karl E.; Phelps, Geoffrey A.

1995-01-01

Introduction The Little Piute Mountains in the eastern Mojave Desert expose a series of folds and thrust faults involving metamorphosed Paleozoic strata (Miller and others, 1982; Stone and others, 1983). Detailed mapping of these structures was undertaken to help elucidate regional Mesozoic structural evolution. Earlier geologic maps were prepared by Cooksley (1960a,b,c,d, generalized by Bishop, 1964) and Stone and others (1983). Deformed and metamorphosed Paleozoic and Triassic rocks form a stratal succession that was originally deposited in shallow seas on the North American craton. Based on lithologic sequence the units are correlated with unmetamorphosed equivalents 200 km to the northeast in the Grand Canyon, Arizona, and 35-50 km to the west in the Marble, Ship, and Providence Mountains, California (Stone and others, 1983). The Paleozoic sequence rests nonconformably on a heterogeneous basement of polydeformed Early Proterozoic gneiss (Miller and others, 1982; Wooden and Miller, 1990). Triassic and older rocks were deformed, metamorphosed to staurolite or andalusite grade, and intruded concordantly at their base by Late Cretaceous granodiorite (Miller and others, 1982).

Alteration assemblages in the Miller Range and Elephant Moraine regions of Antarctica: Comparisons between terrestrial igneous rocks and Martian meteorites

NASA Astrophysics Data System (ADS)

Hallis, L. J.

2013-02-01

The weathering products present in igneous terrestrial Antarctic samples were analyzed, and compared with those found in the four Miller Range nakhlite Martian meteorites. The aim of these comparisons was to determine which of the alteration phases in the Miller Range nakhlites are produced by terrestrial weathering, and what effect rock composition has on these phases. Antarctic terrestrial samples MIL 05031 and EET 96400, along with the Miller Range nakhlites MIL 03346 and 090032, were found to contain secondary alteration assemblages at their externally exposed surfaces. Despite the difference in primary mineralogy, the assemblages of these rocks consist mostly of sulfates (jarosite in MIL 05031, jarosite and gypsum in EET 96400) and iddingsite-like Fe-clay. As neither of the terrestrial samples contains sulfur-bearing primary minerals, and these minerals are rare in the Miller Range nakhlites, it appears that SO42-, possibly along with some of the Na+, K+, and Ca+ in these phases, was sourced from wind-blown sea spray and biogenic emissions from the southern ocean. Cl enrichment in the terrestrially derived "iddingsite" of MIL 05031 and MIL 03346, and the presence of halite at the exterior edge of MIL 090032, can also be explained by this process. However, jarosite within and around the olivine-bound melt inclusions of MIL 090136 is present in the interior of the meteorite and, therefore, is probably the product of preterrestrial weathering on Mars.

Anti-ganglioside antibodies in patients with systemic lupus erythematosus and neurological manifestations.

PubMed

Labrador-Horrillo, M; Martinez-Valle, F; Gallardo, E; Rojas-Garcia, R; Ordi-Ros, J; Vilardell, M

2012-05-01

Anti-ganglioside antibodies (AGA) have been associated with several peripheral neuropathies, such as Miller-Fisher syndrome, Guillain-Barré syndrome and multifocal motor neuropathy. They have also been studied in patients with systemic lupus erythematosus (SLE), focusing on neuropsychiatric manifestations and peripheral neuropathy, but the results are contradictory. To study the presence of AGA in a large cohort of patients with SLE and neuropsychiatric manifestations. Serum from 65 consecutive patients with SLE and neuropsychiatric manifestations, collected from 1985 to 2009, was tested for the presence of AGA antibodies (GM1, GM2, GM3, asialo-GM1 GD1a, GD1b, GD3, GT1b, GQ1b) using a standard enzyme-linked immunosorbent assay ELISA test (INCAT 1999) and thin layer chromatography (TLC). Positive results for asialo-GM1 (IgM) were found in 10 patients, 6 were positive for asialo-GM1 (IgM and IgG), and 4 were positive for other AGA such as GM1, GM2, GM3, GD1b, GT1b, GD3, (mainly IgM). Clinical and statistical studies showed no correlation between AGA and neuropsychiatric manifestations of SLE. Although some patients showed reactivity to AGA, these antibodies are not a useful marker of neuropsychiatric manifestations in SLE patients.

Will Higher Education Pass "A Test of Leadership"? An Interview with Spellings Commission Chairman Charles Miller

ERIC Educational Resources Information Center

Callan, Pat

2007-01-01

Charles Miller, former chairman of the University of Texas System's Board of Regents, chaired the recent Commission on the Future of Higher Education created by Secretary of Education Margaret Spellings. Here he is interviewed regarding the panel's widely discussed report, "A Test of Leadership," by Pat Callan, president of the National…

A Short Study on the Validity of Miller's Theorem Applied to Transistor Amplifier High-Frequency Performance

ERIC Educational Resources Information Center

Schubert, T. F., Jr.; Kim, E. M.

2009-01-01

The use of Miller's Theorem in the determination of the high-frequency cutoff frequency of transistor amplifiers was recently challenged by a paper published in this TRANSACTIONS. Unfortunately, that paper provided no simulation or experimental results to bring credence to the challenge or to validate the alternate method of determination…

Giving Psychology Away: How George Miller's Vision Is Being Realised by Psychological Literacy

ERIC Educational Resources Information Center

Banyard, Philip; Hulme, Julie A.

2015-01-01

In George Miller's famous address to the American Psychological Association in 1969 he explored the aims and future direction of psychology. Psychology could develop as a professional elite that develops specialised knowledge that experts can hold on to or it could aim to "give psychology away" and to allow the general public access to…

Best Traditions Patriotism: A Commentary on Miller, Wingo and Ben-Porath

ERIC Educational Resources Information Center

Blum, Lawrence

2007-01-01

Ben-Porath sees patriotism as involving attachment to fellow citizens as part of a shared fate community. Wingo places shared values at the center of patriotism. Miller argues that political ties to fellow nationals stemming from participation in imposing laws and policies on them will also generate obligations to non-nationals (especially the…

Center of Excellence for Individualization of Therapy for Breast Cancer

DTIC Science & Technology

2008-04-01

cancer - a new therapeutic opportunity. Nat. Rev. Cancer 5, 505-515. Miller,L.D., Smeds ,J., George,J., Vega,V.B., Vergara,L., Ploner,A., Pawitan,Y., Hall...Huang,F., Klaar,S., Liu,E.T., Miller,L., Nordgren,H., Ploner,A., Sandelin,K., Shaw,P.M., Smeds ,J., Skoog,L., Wedren,S., and Bergh,J. (2005). Gene

52. A VIEW OF W.J. MILLER SAWMILL, LOOKING WEST TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

52. A VIEW OF W.J. MILLER SAWMILL, LOOKING WEST TO EAST, AND SHOWING LOCATION OF BOILER HOUSE AND PLANER BUILDING BEFORE PLANER BUILDING AND BOILER HOUSE FOR HULL TO INCORPORATE INTO HIS SAWMILL COMPLETED IN 1939. PHOTOGRAPHER: UNKNOWN. DATE: 1934. COURTESY OF RALPH HULL. - Hull-Oakes Lumber Company, 23837 Dawson Road, Monroe, Benton County, OR

Fire Frequency Effects on Longleaf Pine (Pinus palustris P. Miller) Vegetation in South Carolina and Northeast Florida, USA

Treesearch

Jeff S. Glitzenstein; Donna R. Streng; Dale D. Wade

2003-01-01

Southeastern United States habitats dominated by longleaf pine (Pinus pulutris P. Miller) have declined precipitously in area and extent. Conservation of diverse ground-layer vegetation in these endangered habitats depends on prescribed fire. While the need for prescribed fire is now generally accepted, there is disagreement concerning the most...

WNT Inhibitory Activity of Malus Pumila miller cv Annurca and Malus domestica cv Limoncella Apple Extracts on Human Colon-Rectal Cells Carrying Familial Adenomatous Polyposis Mutations.

PubMed

Riccio, Gennaro; Maisto, Maria; Bottone, Sara; Badolati, Nadia; Rossi, Giovanni Battista; Tenore, Gian Carlo; Stornaiuolo, Mariano; Novellino, Ettore

2017-11-18

Inhibitors of the Wingless-related Integration site (WNT)/β-catenin pathway have recently been under consideration as potential chemopreventive agents against Familial Adenomatous Polyposis (FAP). This autosomal-dominant syndrome is caused by germline mutations in the gene coding for the protein APC and leads to hyperactivation of the WNT/β-catenin signaling pathway, uncontrolled intestinal cell proliferation and formation of adenocarcinomas. The aim of the present work was to: (i) test, on in vitro cultures of cells carrying FAP mutations and on ex vivo biopsies of FAP patients, the WNT inhibitory activity of extracts from two common southern Italian apples, Malus pumila Miller cv. 'Annurca' and Malus domestica cv 'Limoncella'; (ii) identify the mechanisms underpinning their activities and; (iii) evaluate their potency upon gastrointestinal digestion. We here show that both Annurca and Limoncella apple extracts act as WNT inhibitors, mostly thanks to their polyphenolic contents. They inhibit the pathway in colon cells carrying FAP mutations with active dilutions falling in ranges close to consumer-relevant concentrations. Food-grade manufacturing of apple extracts increases their WNT inhibitory activity as result of the conversion of quercetin glycosides into the aglycone quercetin, a potent WNT inhibitor absent in the fresh fruit extract. However, in vitro simulated gastrointestinal digestion severely affected WNT inhibitory activity of apple extracts, as result of a loss of polyphenols. In conclusion, our results show that apple extracts inhibit the WNT pathway in colon cells carrying FAP mutations and represent a potential nutraceutical alternative for the treatment of this pathology. Enteric coating is advisable to preserve the activity of the extracts in the colon-rectal section of the digestive tract.

WNT Inhibitory Activity of Malus Pumila miller cv Annurca and Malus domestica cv Limoncella Apple Extracts on Human Colon-Rectal Cells Carrying Familial Adenomatous Polyposis Mutations

PubMed Central

Maisto, Maria; Bottone, Sara; Badolati, Nadia; Rossi, Giovanni Battista; Novellino, Ettore

2017-01-01

Inhibitors of the Wingless-related Integration site (WNT)/β-catenin pathway have recently been under consideration as potential chemopreventive agents against Familial Adenomatous Polyposis (FAP). This autosomal-dominant syndrome is caused by germline mutations in the gene coding for the protein APC and leads to hyperactivation of the WNT/β-catenin signaling pathway, uncontrolled intestinal cell proliferation and formation of adenocarcinomas. The aim of the present work was to: (i) test, on in vitro cultures of cells carrying FAP mutations and on ex vivo biopsies of FAP patients, the WNT inhibitory activity of extracts from two common southern Italian apples, Malus pumila Miller cv. ‘Annurca’ and Malus domestica cv ‘Limoncella’; (ii) identify the mechanisms underpinning their activities and; (iii) evaluate their potency upon gastrointestinal digestion. We here show that both Annurca and Limoncella apple extracts act as WNT inhibitors, mostly thanks to their polyphenolic contents. They inhibit the pathway in colon cells carrying FAP mutations with active dilutions falling in ranges close to consumer-relevant concentrations. Food-grade manufacturing of apple extracts increases their WNT inhibitory activity as result of the conversion of quercetin glycosides into the aglycone quercetin, a potent WNT inhibitor absent in the fresh fruit extract. However, in vitro simulated gastrointestinal digestion severely affected WNT inhibitory activity of apple extracts, as result of a loss of polyphenols. In conclusion, our results show that apple extracts inhibit the WNT pathway in colon cells carrying FAP mutations and represent a potential nutraceutical alternative for the treatment of this pathology. Enteric coating is advisable to preserve the activity of the extracts in the colon-rectal section of the digestive tract. PMID:29156563

Hydrologic conditions and water-quality conditions following underground coal mining in the North Fork of the Right Fork of Miller Creek drainage basin, Carbon and Emery Counties, Utah, 2004-2005

USGS Publications Warehouse

Wilkowske, C.D.; Cillessen, J.L.; Brinton, P.N.

2007-01-01

In 2004 and 2005, the U.S. Geological Survey, in cooperation with the Bureau of Land Management, reassessed the hydrologic system in and around the drainage basin of the North Fork of the Right Fork (NFRF) of Miller Creek, in Carbon and Emery Counties, Utah. The reassessment occurred 13 years after cessation of underground coal mining that was performed beneath private land at shallow depths (30 to 880 feet) beneath the NFRF of Miller Creek. This study is a follow-up to a previous USGS study of the effects of underground coal mining on the hydrologic system in the area from 1988 to 1992. The previous study concluded that mining related subsidence had impacted the hydrologic system through the loss of streamflow over reaches of the perennial portion of the stream, and through a significant increase in dissolved solids in the stream. The previous study also reported that no substantial differences in spring-water quality resulted from longwall mining, and that no clear relationship between mining subsidence and spring discharge existed.During the summers of 2004 and 2005, the USGS measured discharge and collected water-quality samples from springs and surface water at various locations in the NFRF of Miller Creek drainage basin, and maintained a streamflow-gaging station in the NFRF of Miller Creek. This study also utilized data collected by Cyprus–Plateau Mining Corporation from 1992 through 2001.Of thirteen monitored springs, five have discharge levels that have not returned to those observed prior to August 1988, which is when longwall coal mining began beneath the NFRF of Miller Creek. Discharge at two of these five springs appears to fluctuate with wet and dry cycles and is currently low due to a drought that occurred from 1999–2004. Discharge at two other of the five springs did not increase with increased precipitation during the mid-1990s, as was observed at other monitored springs. This suggests that flowpaths to these springs may have been altered by land subsidence caused by underground coal mining. Analysis of possible impacts to the fifth spring were inconclusive due to a lack of data collected during the mid-1990s. Discharge at eight other monitored springs in the study area appears to be controlled mainly by climatic fluctuations and was generally near the value measured prior to 1988. Discharge at one of these eight springs is significantly greater than that measured during the longwall mining period. Concentrations of magnesium, calcium, sulfate, and dissolved solids at one undermined spring were elevated in relation to other springs in the study area. Dissolved solids concentration at this spring ranged from 539–709 milligrams per liter. Dissolved-solids concentration for all other springs in the study area ranged from 163 to 360 milligrams per liter and was near the median value measured prior to longwall mining beneath the NFRF of Miller Creek drainage basin.Baseflow measured at a streamflow-gaging station on the NFRF of Miller Creek located downstream of the mined area during the summer of 2004 was near 5 gallons per minute. Baseflow in 2005 increased to 7–8 gallons per minute, due to increased precipitation. This is slightly greater than the range of baseflow measured near the end of the longwall mining period which was approximately 3–5 gallons per minute.Seepage investigations carried out in the summer of 2004 and 2005 along the NFRF of Miller Creek showed a net loss of surface flow along the studied reach. Specific areas within the study reach had streamflow losses prior to longwall mining, however, the study reach as a whole was observed to gain in discharge when measured in 1986–1988, immediately before longwall mining began. The area where the greatest loss in discharge from the NFRF of Miller Creek occurred corresponds to an area where overburden (material overlying a deposit of useful geological materials or bedrock) is between 700 and 210 feet thick. Overburden thickness at the place where the streambed first dried up was approximately 600 feet thick. In 2004, approximately 1,600 ft of the streambed of the NFRF of Miller Creek was dry. Only 300 feet of the streambed was dry during the wetter year of 2005. Prior to longwall mining, no dry reaches were observed, though seepage loss was documented. Average discharge measured at a tributary to the NFRF of Miller Creek has increased from 1.6 gallons per minute measured during longwall mining to 7.2 gallons per minute measured in 2004–2005. During both years of this study, the lower reach of the stream regained flow from this tributary and from seepage gains.Water quality in the lower reach of the NFRF of Miller Creek downstream of the longwall-mined area, showed significantly higher concentrations of magnesium, calcium, sulfate, and strontium, in relation to water in the upper reach of the NFRF of Miller Creek and to the springs sampled in the area. Dissolved-solids concentration measured in the lower reach of the stream in 2004 and 2005 ranged from 1,880 to 2,220 milligrams per liter, while sulfate concentrations ranged from 1,090 to 1,320 mg/L. The maximum contaminant level for drinking water in the state of Utah for dissolved solids and sulfate is 2,000 and 1,000 mg/L respectively. Concentrations of these ions are slightly greater than those measured during and just following mining beneath the NFRF of Miller Creek drainage basin, but are significantly higher than those measured prior to mining. With the exception of strontium, dissolved metals concentrations in the NFRF of Miller Creek were similar to those measured in area springs. pH in the creek and at all spring sites was near neutral. Qualitative observations of the creek bottom suggest that mining-related activities have had little effect on vegetative growth.

The Cardiff paediatric laryngoscope blade: a comparison with the Miller size 1 and Macintosh size 2 laryngoscope blades.

PubMed

Jones, R M; Jones, P L; Gildersleve, C D; Hall, J E; Harding, L J E; Chawathe, M S

2004-10-01

The Cardiff paediatric laryngoscope blade is a single blade that has been designed for use in children from birth to adolescence. This open, randomised, crossover study compared the Cardiff blade with the straight, size 1, Miller laryngoscope blade in 39 infants under 1 years of age and the curved, size 2, Macintosh blade in 39 children aged 1-16 years. The same laryngoscopic view was obtained with the Cardiff and Miller blades in 26 patients; the view was better with the Cardiff blade in seven patients and better with the Miller blade in six (median (IQR [range]) grade of laryngoscopy 1 (1-2 [1-3]) vs. 1 (1-2 [1-3]), respectively; p = 0.405). The Cardiff blade was faster at gaining a view than the Miller blade (mean (SD) time 8.5 (2.9) s vs. 10.2 (3.5) s, respectively; 95% CI for difference -2.8 to -0.4; p = 0.009). The Cardiff and Macintosh blades produced the same view in 32 patients; the view was better with the Cardiff blade in seven patients (median (IQR [range]) grade of laryngoscopy 1 (1-1 [1-3]) vs. 1 (1-2 [1-3]), respectively; p = 0.008). There was no difference in time to gain these views: mean (SD) 8.7 (3.0) s vs. 9.3 (2.7) s, respectively (95% CI for difference -1.58 to 0.40; p = 0.237). The Cardiff paediatric laryngoscope blade compares favourably with these two established laryngoscope blades in children.

Mark Miller, PhD | Division of Cancer Prevention

Cancer.gov

Dr. Mark Miller joined DCP's Chemopreventive Agent Development Research Group from the Wake Forest School of Medicine, where he was a Professor in the Department of Cancer Biology and Director of Graduate Studies. Prior to that, he was an Assistant Professor in the Department of Pathology at the University of Tennessee in Knoxville. He worked for NCI as a Senior Staff Fellow

COMMENT: Comment on 'A summation formula for Clausen's series 3F2(1) with an application to Goursat's function 2F2(x)'

NASA Astrophysics Data System (ADS)

Kim, Yong Sup; Rathie, Arjun K.

2008-02-01

In a recent paper, Miller (2005 J. Phys. A: Math. Gen. 38 3541-5) obtained a new summation formula for the Clausen's series 3F2(1). The aim of this comment is to point out that the summation formula obtained by Miller is not a new one.

Joyce McLaren | NREL

Science.gov Websites

. Golden, CO: National Renewable Energy Laboratory. NREL/TP-6A20-64852. McLaren, J. 2015. Reaching 100 Laboratory. NREL/BR-6A20-62490. McLaren J., C. Davidson, J. Miller, and L. Bird. "Impact of Rate Design . Davidson, J. McLaren, and J. Miller. 2015. Impact of Rate Design Alternatives on Residential Solar Customer

Counterrotating Propulsive System.

DTIC Science & Technology

1981-12-01

Propellers ," David Taylor Model Basin Report 1342, February 1960. 7. Miller, M.L., " Experimental Determination of Unsteady Forces on Counter- rotating...21. Miller, M.L., " Experimental Determination of Unsteady Forces on Contra- rotating Propellers for Application to Torpedoes," David W. Taylor Naval...pair of counterrotating propellers in a uniform in- flow is given by Reference [14] with the same results. On the

Test Review: Huer, M. B., & Miller, L. Tecel (2011), "Test of Early Communication and Emerging Language." Austin, TX: Pro-Ed

ERIC Educational Resources Information Center

Hua, Yi

2018-01-01

This article describes and reviews the "Test of Early Communication and Emerging Language" (TECEL; Huer & Miller, 2011). The test was constructed to assess infants' and toddlers' earliest communication and language abilities. The TECEL is a revision of the Nonspeech Test for Receptive/ Expressive Language (NST; Huer, 1983, 1988). The…

The Miller Assessment for Preschoolers: A Longitudinal and Predictive Study. Final Report.

ERIC Educational Resources Information Center

Foundation for Knowledge in Development, Littleton, CO.

The study reported here sought to establish the predictive validity of the Miller Assessment for Preschoolers (MAP), an instrument designed to identify preschool children at risk for school-related problems in the primary years. Children (N=338) in 11 states who were originally tested in 1980 as part of the MAP standardization project were given a…

Dynamic Actuation of Single-Crystal Diamond Nanobeams

DTIC Science & Technology

2014-08-25

3, 275–279. (31) Turner, K. L.; Miller, S. A.; Hartwell, P. G.; MacDonald, N. C.; Strogatz , S. H.; Adams, S. G. Nature 1998, 396, 149–152. (32) Nayfeh...nanotechnology 2008, 3, 275–279. (31) Turner, K. L.; Miller, S. A.; Hartwell, P. G.; MacDonald, N. C.; Strogatz , S. H.; Adams, S. G. Nature 1998, 396, 149

78 FR 5254 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-25

... Pass, RNAV (GPS)-A, Amdt 1 Jonesboro, AR, Jonesboro Muni, ILS OR LOC RWY 23, Amdt 2 Jonesboro, AR, Jonesboro Muni, VOR RWY 23, Amdt 11 Melbourne, AR, Melbourne Muni--John E Miller Field, RNAV (GPS) RWY 3, Amdt 1 Melbourne, AR, Melbourne Muni--John E Miller Field, RNAV (GPS) RWY 21, Amdt 1 Aspen, CO, Aspen...

In Vitro Susceptibilities of Shigella flexneri and Streptococcus pyogenes to Inner Gel of Aloe barbadensis Miller

PubMed Central

Ferro, Valerie A.; Bradbury, Fiona; Cameron, Pamela; Shakir, Eisin; Rahman, Sabita R.; Stimson, William H.

2003-01-01

Aloe barbadensis Miller (or Aloe vera) has widespread use in health products, and despite numerous reports on the whole plant, little work has been performed on the inner gel, which has been used extensively in these products. This report describes the in vitro susceptibilities of two bacteria to this component. PMID:12604556

Miller Creek Demonstration Forest - a forest born of fire: A field guide

Treesearch

Penelope A. Latham; Raymond C. Shearer; Kevin L. O' Hara

1998-01-01

Miller Creek, on the Flathead National Forest in northwest Montana, is a demonstration forest, showing up to 30 years of forest change after clearcutting and a wide range of fire treatments in 1967 and 1968. Differences in tree regeneration and vegetation development are explained for units that were clearcut and prescribed burned, clearcut and burned by wildfire,...

Teachers, Leaders, and Social Justice: A Critical Reflection on a Complicated Exchange

ERIC Educational Resources Information Center

Miller, Cody

2017-01-01

Cody Miller was asked to present on a panel with a fellow doctoral student and a current principal at a local elementary school for a social justice and diversity in school leadership course. Miller's experience on the panel became an informal type of capstone experience as he found himself having to argue and defend social justice teaching…

KSC-2015-1026

NASA Image and Video Library

2015-01-06

CAPE CANAVERAL, Fla. -- During a visit to NASA's Kennedy Space Center in Florida, NASA Chief Technologist David Miller, second from left, tours laboratories inside the Swamp Works facility. Miller is briefed on technology developments in the lab by Jack Fox, chief of the Surface Systems Office in the Engineering and Technology Directorate. At right is Karen Thompson, Kennedy's chief technologist. Photo credit: NASA/Kim Shiflett

Circuits of Spectacle: The Miller Brothers' 101 Ranch Real Wild West

ERIC Educational Resources Information Center

Fields, Alison

2012-01-01

The Miller Brothers' 101 Ranch Real Wild West show ran from 1906 to 1931, outlasting the famous Buffalo Bill's Wild West show by more than a decade. From its beginnings in Oklahoma Territory, the Real Wild West show traveled national and international circuits and built a broad roster of performers, including more than 150 American Indians. During…

Getting Back to the Main Point: A Reply to Miller et al.

ERIC Educational Resources Information Center

Harrison, Allyson G.; Holmes, Alana; Silvestri, Robert; Armstrong, Irene T.

2015-01-01

Miller et al. have challenged the findings of our two previous studies, based largely on the assumption that our findings are biased due to the clinical sample used. However, they fail to address the primary tenet of our studies, namely, that clinicians will obtain different scores on the Wechsler Adult Intelligence Scale-IV (WAIS-IV) depending on…

75 FR 8330 - Miller and Miller; Notice of Termination of License by Implied Surrender and Soliciting Comments...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... 20426. Comments, protests and interventions may be filed electronically via the Internet in lieu of... Proceeding: 18 CFR 6.4 of the Commission's regulations provides, among other things, that it is deemed to be... and interventions may be filed electronically via the Internet in lieu of paper; See 18 CFR 385.2001(a...

Building the Business Case

DTIC Science & Technology

2001-05-15

Building the Business Case Dr Robin Miller Centre for Defence Analysis Report Documentation Page Report Date 15052001 Report Type N/A Dates Covered...from... to) - Title and Subtitle Building the Business Case Contract Number Grant Number Program Element Number Author(s) Miller, Robin...Trade-offs between men/materiel/process can be made coherent – auditable links to operational risk can be maintained Business Case Challenge for SBA

An Evaluation of the Psychometric Properties of Three Different Forms of Daly and Miller's Writing Apprehension Test through Rasch Analysis

ERIC Educational Resources Information Center

Güler, Nese; Ilhan, Mustafa; Güneyli, Ahmet; Demir, Süleyman

2017-01-01

This study evaluates the psychometric properties of three different forms of the Writing Apprehension Test (WAT; Daly & Miller, 1975) through Rasch analysis. For this purpose, the fit statistics and correlation coefficients, and the reliability, separation ratio, and chi-square values for the facets of item and person calculated for the…

Opuntia ficus-indica (L.) Miller as a source of bioactivity compounds for health and nutrition.

PubMed

Aragona, M; Lauriano, E R; Pergolizzi, S; Faggio, C

2017-08-14

Plants with beneficial properties are known in traditional medicine. Nowadays, in spite of widespread availability of synthetic compounds, the search goes towards natural compounds to lower cost and few side effects. The increasing interest in preventive medicine encourages use of nutraceuticals, bioactive compounds of vegetable origin with important nutritional values. Among the medicinal plants, Opuntia ficus-indica (L.) Miller (Family Cactaceae, subfamily Opuntiodeae, Genus Opuntia, subgenus Platyopuntia, species Opuntia ficus-indica (L.) Miller) is widely known for its beneficial properties. The aim of the present review is to stress the major classes of Opuntia components and their medical interest through emphasis on some of their biological effects, particularly those having the most promising expected health benefits and therapeutic impacts on fish and mammals.

Prebiotic Soup-Revisiting the Miller Experiment

NASA Technical Reports Server (NTRS)

Bada, Jeffrey L.; Lazcano, Antonio

2003-01-01

'Isn't life wonderful?' sang Alma Cogan and Les Howard in their almost forgotten 1953 hit. That same year, Stanley L. Miller raised the hopes of understanding the origin of life when on 15 May, Science published his paper on the synthesis of amino acids under conditions that simulated primitive Earth's atmosphere. Miller had applied an electric discharge to a mixture of CH4, NH3, H2O, and H2 - believed at the time to be the atmospheric composition of early Earth. Surprisingly, the products were not a random mixture of organic molecules, but rather a relatively small number of biochemically significant compounds such as amino acids, hydroxy acids, and urea. With the publication of these dramatic results, the modem era in the study of the origin of life began.

Prebiotic Soup: Revisiting the Miller Experiment

NASA Technical Reports Server (NTRS)

Bada, Jeffrey L.; Lazcano, Antonio

2003-01-01

Isn't life wonderful? sang Alma Cogan and Les Howard in their almost forgotten 1953 hit. That same year, Stanley L. Miller raised the hopes of understanding the origin of life when on 15 May, Science published his paper on the synthesis of amino acids under conditions that simulated primitive Earth's atmosphere. Miller had applied an electric discharge to a mixture of CH4, NH3, H2O, and H2 - believed at the time to be the atmospheric composition of early Earth. Surprisingly, the products were not a random mixture of organic molecules. but rather a relatively small number of biochemically significant compounds such as amino acids, hydroxy acids, and urea. With the publication of these dramatic results, the modern era in the study of the origin of life began.

Detection Strategies for Malingering with the Miller Forensic Assessment of Symptoms Test: A Confirmatory Factor Analysis of Its Underlying Dimensions

ERIC Educational Resources Information Center

Vitacco, Michael J.; Jackson, Rebecca L.; Rogers, Richard; Neumann, Craig S.; Miller, Holly A.; Gabel, Jason

2008-01-01

Two of the most widely used measures for the assessment of malingering in forensic populations are the Miller Forensic Assessment of Symptoms Test (M-FAST) and the Structured Interview of Reported Symptoms (SIRS). The underlying dimensions of the SIRS have been well established in the literature, but the structure of the M-FAST remains relatively…

Effects of Benthic Barriers on Macroinvertebrate Communities

DTIC Science & Technology

1993-10-01

Aquatic Plant Control Research Program Effects of Benthic Barriers on Macroinvertebrate Communities by Barry S. Payne, Andrew C. Miller Environmental...Plant Control Technical Report A-93-5Resear h Program Oct ber 1993 Effects of Benthic Barriers on Macroinvertebrate Communities by Barry S. Payne...Effects of benthic barriers on macroinvertebrate communities / by Barry S. Payne, Andrew C. Miller, [and] Thomas Ussery ; prepared for U.S. Army Corps of

Modal Theory of Transverse Acoustic Coherence in Shallow Oceans

DTIC Science & Technology

2012-09-28

J. Ocean. Eng. 24(3), 333–345 (1999). 54. J. F. Lynch, G. Jin, R. Pawlowicz, D. Ray, A. J. Plueddenmann, C.-S. Chiu, J. H. Miller, R. H. Bourke , A. R...Theory and experiment,” J. Acoust. Soc. Am. 99(2), 803–821 (1996). 55. A. R. Parsons, R. H. Bourke , R. D. Muench, C.-S. Chiu, J. F. Lynch, J. H. Miller

Regulated Ubiquitinylation-Dependent Corepressor and Coactivator Complex Exchange as a Potential Target in Estrogen-Dependent Breast Cancer

DTIC Science & Technology

2006-09-01

Appendices B) References Miller, L. D., Smeds , J., George, J., Vega, V. B., Vergara, L., Ploner, A., Pawitan, Y., Hall, P., Klaar, S., Liu, E. T...Liyanarachchi S, Yan PS, Leu YW, Chan MW, Plass C, Nephew KP, et al. (2006) Mol Cell 21:393–404. 40. Miller LD, Smeds J, George J, Vega VB, Vergara L

The Use of the Miller Analogies Test as a Screening Device for Mexican-American Graduate Students.

ERIC Educational Resources Information Center

Duling, John A.

The determination of whether or not the Miller Analogies Test (MAT) is a valid screening device to use with a culturally diverse populace was examined. The study was conducted at New Mexico State University (NMSU) using 2 sample groups. Sample A consisted of 560 Anglos and 101 Mexican Americans tested by the NMSU Counseling Center during a 2-year…

Charles Miller Fisher: the 65th anniversary of the publication of his groundbreaking study "Transient Monocular Blindness Associated with Hemiplegia".

PubMed

Araújo, Tiago Fernando Souza de; Lange, Marcos; Zétola, Viviane H; Massaro, Ayrton; Teive, Hélio A G

2017-10-01

Charles Miller Fisher is considered the father of modern vascular neurology and one of the giants of neurology in the 20th century. This historical review emphasizes Prof. Fisher's magnificent contribution to vascular neurology and celebrates the 65th anniversary of the publication of his groundbreaking study, "Transient Monocular Blindness Associated with Hemiplegia."

The Relationship between Socio-Economic Status and the Frequency of School Web Page Access to Both Mobile and Non-Mobile Sites

ERIC Educational Resources Information Center

Parker, Richmond Hughes

2013-01-01

Research has shown that student performance increases when parents become more involved in their children's education, and the positive influence of parental involvement has been shown to persist across racial, gender, and socio-economic barriers (Miller, Adsit, & Miller, 2005). As a result, an increasing number of schools have sought to use…

WSTB appoints New Members

NASA Astrophysics Data System (ADS)

Anderson, Mary P.

Paul Busch (Malcolm Pirnie), Leo Eisel (Wright Water Engineers), and Mary P. Anderson (University of Wisconsin—Madison) have been appointed to 3-year terms as members of the Water Science and Technology Board (WSTB) of the National Research Council (NRC), and David W. Miller (Geraghty & Miller, Inc.) has been appointed to a second term. The WSTB was established in 1982 to oversee the National Research Council's activities related to water resources.

75 FR 19956 - Miller and Miller, Waterpower LLC; Notice of Application for Transfer of License and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

...) filed an application for transfer of license of the Worthville Dam Project No. 3156, located on the Deep.... See 18 CFR 385.2001(a)(1)(iii)(2008) and the instructions on the Commission's Web site under the ``e... filings please go to the Commission's Web site located at http://www.ferc.gov/filing-comments.asp . More...

Validation of FFM PD counts for screening personality pathology and psychopathy in adolescence.

PubMed

Decuyper, Mieke; De Clercq, Barbara; De Bolle, Marleen; De Fruyt, Filip

2009-12-01

Miller and colleagues (Miller, Bagby, Pilkonis, Reynolds, & Lynam, 2005) recently developed a Five-Factor Model (FFM) personality disorder (PD) count technique for describing and diagnosing PDs and psychopathy in adulthood. This technique conceptualizes PDs relying on general trait models and uses facets from the expert-generated PD prototypes to score the FFM PDs. The present study corroborates on the study of Miller and colleagues (2005) and investigates in Study 1 whether the PD count technique shows discriminant validity to describe PDs in adolescence. Study 2 extends this objective to psychopathy. Results suggest that the FFM PD count technique is equally successful in adolescence as in adulthood to describe PD symptoms, supporting the use of this descriptive method in adolescence. The normative data and accompanying PD count benchmarks enable to use FFM scores for PD screening purposes in adolescence.

Systemic Metabolic Derangement, Pulmonary Effects, and Insulin Insufficiency Following Subchronic Ozone Exposure in Rats

EPA Pesticide Factsheets

This data set includes individual animal data collected for various biological endpoints that are included in the manuscript.Miller DB, Snow SJ, Henriquez A, Schladweiler MC, Ledbetter AD, Richards JE, Andrews DL, Kodavanti UP. Systemic metabolic derangement, pulmonary effects, and insulin insufficiency following subchronic ozone exposure in rats. Toxicol Appl Pharmacol. 2016 Jun 28;306:47-57. The primary author Desinia Miller, an UNC-EPA co-opp Student has since completed her PhD and is no longer in EPA database.This dataset is associated with the following publication:Miller, D., S. Snow, A. Henriquez, M. Schladweiler, A. Ledbetter, J. Richards, D. Andrews, and U. Kodavanti. Systemic Metabolic Derangement, Pulmonary Effects, and Insulin Insufficiency following subchronic ozone exposure in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 306: 47-57, (2016).

Growth inhibition of Dalmatian toadflax, Linaria dalmatica (L.) Miller, in response to herbivory by the biological control agent Mecinus janthinus Germar

Treesearch

Marjolein Schat; Sharlene E. Sing; Robert K. D. Peterson; Fabian D. Menalled; David K. Weaver

2011-01-01

Our study reports the results of field and garden experiments designed to quantitatively evaluate the impact of herbivory by a weed biological control agent, the stem-mining weevil Mecinus janthinus Germar, on the growth of its exotic host Dalmatian toadflax, Linaria dalmatica (L.) Miller. Herbivory by M. janthinus under both natural and manipulated environmental...

A Tribute to Professor Rene H. Miller - A Pioneer in Aeromechanics and Rotary Wing Flight Transportation

NASA Technical Reports Server (NTRS)

Friedmann, Peretz P.; Johnson, Wayne; Scully, Michael P.

2011-01-01

Rene H. Miller (May 19, 1916 January 28, 2003), Emeritus H. N. Slater Professor of Flight Transportation, was one of the most influential pioneers in rotary wing aeromechanics as well as a visionary whose dream was the development of a tilt-rotor based short haul air transportation system. This paper pays a long overdue tribute to his memory and to his extraordinary contributions.

Georgetown University and Hampton University Prostate Cancer Undergraduate Fellowship Program

DTIC Science & Technology

2015-10-01

Tyanna Jones-Gray (Dr. Vicente Notario), Ms. Damara Miller (Dr. Eliot Rosen), Ms. Jasmine Hatcher-Moorman (Dr. MaryBeth Martin), and Mr. Isaiah Brown...undergraduate students: 1. The Hampton University undergraduates (Ms. Tyanna Jones-Gray, Ms. Damara Miller, Ms. Jasmine Hatcher-Moorman, and Mr...cancer progression. Dr. Martin’s lab has identified the environmental hormones referred to as metallo- hormones. In Dr. Martin’s laboratory, Jasmine

David Miller | NREL

Science.gov Websites

Publications D.C. Miller, E. Annigoni, A. Ballion, J.G. Bokria, L.S. Bruckman, D.M. Burns, X. Chen, L. Elliott , J. Feng, R.H. French, S. Fowler, C.C. Honeker, M.D. Kempe, H. Khonkar, M. Köhl, L.-E. Perret-Aebi , L. Elliott, L. Feng, R.H. French, S. Fowler, X. Gu, P.L. Hacke, C.C. Honeker, M.D. Kempe, H. Khonkar

Commensal Gut-Derived Anaerobes as Novel Therapy for Inflammatory Autoimmune Diseases

DTIC Science & Technology

2012-05-01

Luckey D, Marietta EV, Miller ME, Murray JA, White BA and Taneja V. 2012. HLA-DR polymorphism, gut microbiome and sex may predict susceptibility or...Gomez A, Yoeman C, Luckey D, Marietta EV, Miller ME, Murray JA, White BA and Taneja V. 2012. HLA-DR polymorphism, gut microbiome and sex may... Gut -Derived Anaerobes as Novel Therapy for Inflammatory Autoimmune Diseases Veena Taneja Mayo Clinic Rochester, MN 55905

A Comparison of Intrathecal and Epidural Analgesia and Its Effect on Length of Labor

DTIC Science & Technology

1997-09-10

time of delivery (Chestnut, Vandewalker, Owen, Bates, & Choi, 1987 ). Epidural or intiathecal injection of opioids has the potential to provide selective...exists pertaining to this issue (Miller, DeVore, & Eisler , 1993). Selective opioid analgesia whether epidural or intrathecal has also resulted in...of contraction of the utems and the pressure generated by these contractions (Miller, DeVore, & Eisler , 1993). Progress of labor: Increasing

Lissencephaly-1 dependent axonal retrograde transport of L1-type CAM Neuroglian in the adult drosophila central nervous system

PubMed Central

Börner, Jana; Slipchuk, Olesya; Kakad, Priyanka; Lee, LaTasha H.; Qureshi, Aater; Pielage, Jan

2017-01-01

Here, we established the Drosophila Giant Fiber neurons (GF) as a novel model to study axonal trafficking of L1-type Cell Adhesion Molecules (CAM) Neuroglian (Nrg) in the adult CNS using live imaging. L1-type CAMs are well known for their importance in nervous system development and we previously demonstrated a role for Nrg in GF synapse formation. However, in the adult they have also been implicated in synaptic plasticity and regeneration. In addition, to its canonical role in organizing cytoskeletal elements at the plasma membrane, vertebrate L1CAM has also been shown to regulate transcription indirectly as well as directly via its import to the nucleus. Here, we intend to determine if the sole L1CAM homolog Nrg is retrogradley transported and thus has the potential to relay signals from the synapse to the soma. Live imaging of c-terminally tagged Nrg in the GF revealed that there are at least two populations of retrograde vesicles that differ in speed, and either move with consistent or varying velocity. To determine if endogenous Nrg is retrogradely transported, we inhibited two key regulators, Lissencephaly-1 (Lis1) and Dynactin, of the retrograde motor protein Dynein. Similar to previously described phenotypes for expression of poisonous subunits of Dynactin, we found that developmental knock down of Lis1 disrupted GF synaptic terminal growth and that Nrg vesicles accumulated inside the stunted terminals in both mutant backgrounds. Moreover, post mitotic Lis1 knock down in mature GFs by either RNAi or Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) induced mutations, resulted in normal length terminals with fully functional GF synapses which also exhibited severe accumulation of endogenous Nrg vesicles. Thus, our data suggests that accumulation of Nrg vesicles is due to failure of retrograde transport rather than a failure of terminal development. Together with the finding that post mitotic knock down of Lis1 also disrupted retrograde transport of tagged Nrg vesicles in GF axons, it demonstrates that endogenous Nrg protein is transported from the synapse to the soma in the adult central nervous system in a Lis1-dependent manner. PMID:28837701

Lissencephaly-1 dependent axonal retrograde transport of L1-type CAM Neuroglian in the adult drosophila central nervous system.

PubMed

Kudumala, Sirisha R; Penserga, Tyrone; Börner, Jana; Slipchuk, Olesya; Kakad, Priyanka; Lee, LaTasha H; Qureshi, Aater; Pielage, Jan; Godenschwege, Tanja A

2017-01-01

Here, we established the Drosophila Giant Fiber neurons (GF) as a novel model to study axonal trafficking of L1-type Cell Adhesion Molecules (CAM) Neuroglian (Nrg) in the adult CNS using live imaging. L1-type CAMs are well known for their importance in nervous system development and we previously demonstrated a role for Nrg in GF synapse formation. However, in the adult they have also been implicated in synaptic plasticity and regeneration. In addition, to its canonical role in organizing cytoskeletal elements at the plasma membrane, vertebrate L1CAM has also been shown to regulate transcription indirectly as well as directly via its import to the nucleus. Here, we intend to determine if the sole L1CAM homolog Nrg is retrogradley transported and thus has the potential to relay signals from the synapse to the soma. Live imaging of c-terminally tagged Nrg in the GF revealed that there are at least two populations of retrograde vesicles that differ in speed, and either move with consistent or varying velocity. To determine if endogenous Nrg is retrogradely transported, we inhibited two key regulators, Lissencephaly-1 (Lis1) and Dynactin, of the retrograde motor protein Dynein. Similar to previously described phenotypes for expression of poisonous subunits of Dynactin, we found that developmental knock down of Lis1 disrupted GF synaptic terminal growth and that Nrg vesicles accumulated inside the stunted terminals in both mutant backgrounds. Moreover, post mitotic Lis1 knock down in mature GFs by either RNAi or Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) induced mutations, resulted in normal length terminals with fully functional GF synapses which also exhibited severe accumulation of endogenous Nrg vesicles. Thus, our data suggests that accumulation of Nrg vesicles is due to failure of retrograde transport rather than a failure of terminal development. Together with the finding that post mitotic knock down of Lis1 also disrupted retrograde transport of tagged Nrg vesicles in GF axons, it demonstrates that endogenous Nrg protein is transported from the synapse to the soma in the adult central nervous system in a Lis1-dependent manner.

The incidental finding of elevated anti GQ1B antibodies in a patient with selective small fiber neuropathy.

PubMed

Favoni, Valentina; Liguori, Rocco; Incensi, Alex; Fileccia, Enrico; Donadio, Vincenzo

2018-05-15

Small fiber neuropathy (SFN) selectively affects small diameter sensory and/or autonomic axons. Pain and autonomic dysfunctions are the most common symptoms. SFN occurs in several autoimmune diseases and autoantibodies against neuronal proteins may play a role in SFN pathophysiology. Anti-GQ1b antibody has been associated with Miller Fisher syndrome, Bickerstaff's brainstem encephalitis, acute ophthalmoplegia, pharyngeal-cervical-brachial weakness and peripheral neuropathy involving large fibers. Isolated SFN associated with anti-GQ1b antibodies has not been previously reported. Here we report a 45-year-old woman presenting with highly positive anti-GQ1b titer and selective SFN without central nervous system or peripheral large nerve involvement. She improved upon administration of adalizumab. Further studies will clarify a possible pathogenetic role of antiganglioside antibodies in SFN. Moreover, the recognition of antiganglioside antibodies in SFN may have therapeutic consequences with patients who would benefit from immunotherapy. Copyright © 2018 Elsevier B.V. All rights reserved.

KSC-2010-3967

NASA Image and Video Library

2010-06-18

Mike Miller demonstrates one of the backpacks his team designed and built for the Desert Research and Technology Studies project's upcoming field test in Arizona. Miller led the team that developed the backpacks. The backpacks are equipped with GPS antennas, communications components and cameras. They are meant to show researchers what an astronaut might need to explore an alien world and give designers a look at the hardships the equipment could encounter. Photo credit: NASA/Frank Michaux

Best Practices Case Study: John Wesley Miller Companies - Armory Park Del Sol, Tucson, AZ

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Case study of John Wesley Miller Companies, who built two net zero energy homes plus 97 other solar homes in Tucson, AZ. Masonry block walls with rigid foam exterior sheathing, rigid foam over the roof deck plus R-38 in the attic, ducts in conditioned space, 4.2 kW and 5.7 kW photovoltaics and solar water heating yielded HERS scores of 0 on the two homes.

Accelerated Corrosion Results for Zinc/Nickel-Plated Automotive Parts Posttreated With Trivalent Chromate Rinse

DTIC Science & Technology

2010-09-01

400 and 300 h in neutral salt spray. 5 Similarly plated samples post treated with trivalent chromium rinse lasted 450 and 200 h in neutral salt...Accelerated Corrosion Results for Zinc/Nickel-Plated Automotive Parts Posttreated With Trivalent Chromate Rinse by Chris E. Miller, Brian E...Posttreated With Trivalent Chromate Rinse Chris E. Miller and Brian E. Placzankis Weapons and Materials Research Directorate, ARL I. Carl Handsy

Sustaining Air Force Aging Aircraft into the 21st Century

DTIC Science & Technology

2011-08-01

Yankel, AFMC CXI SAB Members: Mrs. Natalie Crawford Prof Mark Goorsky Mr. Neil Kacena Prof. David W. Miller Dr. Robert Schafrik Prof. Douglas...D. Eick Professor Mark S. Goorsky Mr. Neil G. Kacena Professor David W. Miller Dr. Robert E. Schafrik Dr. Douglas C. Schmidt Professor Daniel L...AFB, UT. Ivey, R., & Heath , R. (2011, April). Implementing MECSIP Through a Reliability Centered Maintenance Program for the Air Force C-130 SPO

Joint Rapid Airfield Construction (JRAC) 2007 Technology Demonstration

DTIC Science & Technology

2008-07-01

ER D C/ G SL T R- 08 -1 7 Joint Rapid Airfield Construction (JRAC) 2007 Technology Demonstration Gary L. Anderton, Ernest S. Berney IV...Technology Demonstration Gary L. Anderton, Ernest S. Berney IV, Travis A. Mann, J. Kent Newman, E. Alex Baylot, Daniel K. Miller, and Quint Mason... Berney IV, Dr. J. Kent Newman, Daniel K. Miller, Quint Mason, Airfields and Pavements Branch (APB), and E. Alex Baylot, Mobility Systems Branch. The

Joint Operational Fires in the Offense: The Southwest Pacific Campaign to Isolate Rabaul

DTIC Science & Technology

2014-05-22

Boyne , Operation Iraqi Freedom: What Went Right, What Went Wrong, and Why (New York: Forge, 2003), 128-133; Hollis, 6-7. 5...Cartwheel Area Source: John Miller, Cartwheel: The Reduction of Rabaul (Washington, DC: Government Printing Office, 1959), 23 17 On New Guinea...The Years of MacArthur, Volume II: 1941-1945, vol. 2, 3 vols. (Boston: Houghton Mifflin, 1976), 98, 119-121, 153-154; John Miller, Guadalcanal: The

Mortality of Talc Miners and Millers From Val Chisone, Northern Italy: An Updated Cohort Study.

PubMed

Pira, Enrico; Coggiola, Maurizio; Ciocan, Catalina; Romano, Canzio; La Vecchia, Carlo; Pelucchi, Claudio; Boffetta, Paolo

2017-07-01

The aim of this study was to update the analysis of mortality of a cohort of talc miners and millers in Northern Italy. We analyzed the mortality during 1946 to 2013 of 1722 male workers in an asbestos-free talc mine (1166 miners and 556 millers) employed during 1946 to 1995. The overall standardized mortality ratio (SMR) was 1.24 [95% confidence interval (95% CI) 1.17 to 1.32]; no deaths were observed from pleural cancer; mortality from lung cancer was not increased. Mortality from pneumoconiosis was increased (SMR 26.62; 95% CI 20.71 to 33.69), in particular among miners, and was associated with duration of employment and time since first employment. We confirmed the lack of association between exposure to asbestos-free talc, lung cancer, and mesothelioma. Increased mortality from pneumoconiosis among miners is attributable to past exposure to silica.

ecco: An error correcting comparator theory.

PubMed

Ghirlanda, Stefano

2018-03-08

Building on the work of Ralph Miller and coworkers (Miller and Matzel, 1988; Denniston et al., 2001; Stout and Miller, 2007), I propose a new formalization of the comparator hypothesis that seeks to overcome some shortcomings of existing formalizations. The new model, dubbed ecco for "Error-Correcting COmparisons," retains the comparator process and the learning of CS-CS associations based on contingency. ecco assumes, however, that learning of CS-US associations is driven by total error correction, as first introduced by Rescorla and Wagner (1972). I explore ecco's behavior in acquisition, compound conditioning, blocking, backward blocking, and unovershadowing. In these paradigms, ecco appears capable of avoiding the problems of current comparator models, such as the inability to solve some discriminations and some paradoxical effects of stimulus salience. At the same time, ecco exhibits the retrospective revaluation phenomena that are characteristic of comparator theory. Copyright © 2018 Elsevier B.V. All rights reserved.

Basic mechanisms of MCD in animal models.

PubMed

Battaglia, Giorgio; Becker, Albert J; LoTurco, Joseph; Represa, Alfonso; Baraban, Scott C; Roper, Steven N; Vezzani, Annamaria

2009-09-01

Epilepsy-associated glioneuronal malformations (malformations of cortical development [MCD]) include focal cortical dysplasias (FCD) and highly differentiated glioneuronal tumors, most frequently gangliogliomas. The neuropathological findings are variable but suggest aberrant proliferation, migration, and differentiation of neural precursor cells as essential pathogenetic elements. Recent advances in animal models for MCDs allow new insights in the molecular pathogenesis of these epilepsy-associated lesions. Novel approaches, presented here, comprise RNA interference strategies to generate and study experimental models of subcortical band heterotopia and study functional aspects of aberrantly shaped and positioned neurons. Exciting analyses address impaired NMDA receptor expression in FCD animal models compared to human FCDs and excitatory imbalances in MCD animal models such as lissencephaly gene ablated mice as well as in utero irradiated rats. An improved understanding of relevant pathomechanisms will advance the development of targeted treatment strategies for epilepsy-associated malformations.

Comprehensive Methods for Determining Space Effects on Air Force Systems

DTIC Science & Technology

2009-08-04

Midey Thomas M. Miller Dale J. Levandier Ernest Hole man David F. Webb Kevin Martin Boston College Institute for Scientific Research 140... Seeley , and J. Troe, "Collisional stabilization and thermal dissociation of vibrationally highly excited G)Hi2+ ions in the reaction 02 + + C9H12...Ehlerding, F. Hellberg, S. Kalhori, R. D. Thomas , O. Novotny, S. T. Arnold, T. M. Miller, A. A. Viggiano, and M. Larsson, "First observation of four-body

GWOT Vascular Injury Study 2 Supplemental Project: Impact of Prophylactic Fasciotomy

DTIC Science & Technology

2017-10-01

of the project ? The overall goal is to determine the impact of the widespread use of fasciotomies on current medical/surgical practices, management ...Diane Miller Project Role: Program Manager Nearest person month worked: 12 Contribution to Project : Ms. Miller is responsible for the day-to-day...each branch of service. Goals/Milestones CY14 Goal – Protocol/Staffing  Write and submit protocol to IRB  Hire project manager CY15 Goals – Data

Langmuir-Blodgett Films of Aromatic Schiff’s Bases Functionalized in the Side Chains of Polymethacrylate

DTIC Science & Technology

1991-05-03

Report No. 21 - Latigmuir-Blodgett Films of Aromatic Schiffs Bases , K Fuctionalized in the Side Chains of Polymethacrylate by T. Takahashi, P. Miller...aromatic Schiff’s bases functionalized in the side chains of Polymethacrylate T. Takahashi**, P. Miller*, Y. M. Chen*, L. Samuelson***, D. Galotti, B...has been investigated for polymers in which nonlinear optical (NLO) moieties are attachcd i, the side chain of polymethacrylate (PMA) backbone. Polymer

Gabriella Miller Kids First (GMKF/Kids First) Pediatric Research Program | Office of Cancer Genomics

Cancer.gov

The Gabriella Miller Kids First initiative is a trans-NIH effort to increase understanding of genetic changes associated with certain devastating pediatric conditions. The initiative will develop a centralized database of well-curated clinical and genetic sequence data from childhood cancer and structural birth defects cohorts comprising thousands of patients and their families. To learn more about the initiative and the data available, please visit https://commonfund.nih.gov/kidsfirst

Comparison of glottic visualisation and ease of intubation with different laryngoscope blades.

PubMed

Kulkarni, Atul P; Tirmanwar, Amar S

2013-03-01

Literature suggests glottic view is better with straight blades while tracheal intubation is easier with curved blades. To compare glottic view and ease of intubation with Macintosh, Miller, McCoy blades and the Trueview(®) laryngoscope. This prospective randomised study was undertaken in operation theatres of a 550 bedded tertiary referral cancer centre after approval from the Institutional Review Board. We compared the Macintosh, Miller, McCoy blades and the Trueview(®) laryngoscope for glottic visualisation and ease of tracheal intubation; in 120 patients undergoing elective cancer surgery; randomly divided into four groups. After induction of anaesthesia laryngoscopy was performed and trachea intubated. We recorded: Visualisation of glottis (Cormack Lehane grade), ease of intubation, number of attempts; need to change the blade and need for external laryngeal manipulation. Demographic data, Mallampati classification were compared using the Chi-square test. A P<0.05 was considered significant. Grade 1 view was obtained most often (87% patients) with Trueview(®) laryngoscope. Intubation was easier (Grade 1) with Trueview(®) and McCoy blades (93% each). Seven patients needed two attempts; one patient in Miller group needed three attempts. No patient in McCoy and Trueview(®) Groups required external laryngeal manipulation. We found that in patients with normal airway glottis was best visualised with Miller blade and Trueview(®) laryngoscope however, the trachea was more easily intubated with McCoy and Macintosh blades and Trueview(®) laryngoscope.

Miller's best/enhanced practices for flour fortification at the flour mill.

PubMed

Johnson, Quentin W; Wesley, Annie S

2010-03-01

Cereal flour fortification has been identified as an effective mass fortification intervention as part of a national public health strategy to overcome micronutrient deficiencies and improve the health status of populations, especially women and children. The effectiveness of cereal flour fortification programs requires the use of micronutrient premixes that provide the desired health benefits. The Miller's Best/Enhanced Practices for Flour Fortification at the flour mill has been developed to provide specific guidance to millers and government officials to ensure that flour fortification practices are carried out in a way that results in the anticipated public health impact. The paper provides information specific to the use of micronutrient premixes, feeders, the fortification process, and quality control systems to ensure that both minimum and enhanced practices can be followed by the millers. Guidelines for basic and best/enhanced practices to be followed for each stage of the flour fortification process at the flour mill are presented. The paper is designed to be a companion to the Recommended Practices for the Production and Procurement of Premix used in Cereal Fortification Programs and supplementary to existing food quality manuals and systems, such as Good Manufacturing Practices, Food Quality Systems, and Hazard Analysis and Critical Control Points. Other stakeholders involved in flour fortification programs have the responsibility to follow best practices of their own to ensure optimum effectiveness.

Interpersonal sensitivity, social inhibition, and type D personality: how and when are they associated with health? Comment on Marin and Miller (2013).

PubMed

Denollet, Johan

2013-09-01

Marin and Miller (2013) proposed interpersonal sensitivity (IS), characterized by ongoing concerns about social threats, as a new model to integrate research on interpersonal traits and health. They concluded that IS is associated with infectious and cardiovascular disease but not cancer or all-cause mortality and discussed a clear agenda for future research. However, the evidence on IS and health is mixed, and there still is much to be learned about the pathways that underpin these associations and moderators that reveal at what age and in what subgroups such associations hold. Marin and Miller noted that a toxic core of IS could be social inhibition, a related but distinct trait that refers to inhibited behavior during social interaction. On the basis of their proposition, I suggest an alternative model that points to social inhibition as an underlying trait that paves the way to IS. Social inhibition is a major determinant of chronic social stress in children and nonhuman primates. Yet, it remains uncertain whether social inhibition and its interaction with negative affectivity in Type D personality, is also related to health outcomes in adults. Many other challenges remain, but this important work of Marin and Miller highlights the need for more research on IS, social inhibition, and health. (c) 2013 APA, all rights reserved.

Evaluation of periosteum eversion and coronally advanced flap techniques in the treatment of isolated Miller's Class I/II gingival recession: A comparative clinical study

PubMed Central

Debnath, Koel; Chatterjee, Anirban

2018-01-01

Aim: The present investigation aimed to evaluate root coverage (RC) with periosteum eversion technique (PET) using periosteum as a graft and coronally advanced flap (CAF) with platelet-rich fibrin (PRF) membrane as a graft in the treatment of isolated Miller's class I and II gingival recession defects. Materials and Methods: Thirty sites in 15 participants with Miller's Class I or II gingival recession were randomly treated either with PET using periosteum as graft and CAF + PRF as graft. In a split mouth design, the parameters such as recession depth, recession width at cementoenamel junction, probing depth, periodontal attachment level (PAL), and keratinized gingival width were assessed at baseline, 3 months, and 6 months postoperative follow-up with William's graduated probe and Vernier caliper. Results: Both the treatment modalities yielded statistically nonsignificant desirable treatment outcomes at both postoperative levels in terms of all the parameters The mean RC with probe method and Vernier method in CAF + PRF was 75.01% and 86.86%, respectively, and PET showed a mean RC of 61.112% and 83.971%, respectively, at 6-month interval period which showed a nonstatistically significant difference. Conclusion: Both the treatment modalities, i.e., CAF + PRF and PET are essentially and equally effective in the treatment of Miller's Class I or II gingival recession defects. PMID:29769769

Loess stratigraphy of the Lower Mississippi Valley

USGS Publications Warehouse

Rutledge, E.M.; Guccione, M.J.; Markewich, H.W.; Wysocki, D.A.; Ward, L.B.

1996-01-01

Loesses of the Lower Mississippi Valley (LMV) are world-famous. Sir Charles Lyell (1847), Hilgard (1860), Stafford (1869), Call (1891) and Mabry (1898), thought the LMV loess was a single water deposit although "double submergence" was noted by Call (1891) and Salisbury (1891). Shimek (1902) and Emerson (1918) recognized LMV loess as a wind deposit which came from the valley. Although wind-deposited loess gained wide acceptance, Russell (1944a) published his controversial theory of "loessification" which entailed weathering of backswamp deposits, downslope movement and recharge by carbonates to form loess. Wascher et al. (1947) identified three LMV loesses, mapped distributions and strongly supported eolian deposition. Leighton and Willman (1950), identified four loesses and supported eolian deposition as did Krinitzsky and Turnbull (1967) and Snowden and Priddy (1968), but Krinitzsky and Turnbull questioned the deepest loess. Daniels and Young (1968) and Touchet and Daniels (1970) studied the distribution of loesses in south-central Louisiana. West et al. (1980) and Rutledge et al. (1985) studied the source areas and wind directions which deposited the loesses on and adjoining Crowley's Ridge. B.J. Miller and co-workers (Miller et al., 1985, 1986, Miller and Alford, 1985) proposed that the Loveland Silt was Early Wisconsin rather than Illinoian age and advanced the name Sicily Island loess. They proposed the underlying loess was Illinoian and advanced the name Crowley's Ridge. We termed the loesses, from the surface downward, Peoria Loess, Roxana Silt, Loveland/Sicily Island loess, Crowley's Ridge Loess and Marianna loess. Researchers agree that the surfical Peoria Loess is Late Wisconsin and the Roxana Silt is Late to Middle Wisconsin, but little agreement exists on the age of the older loesses. Pye and Johnson (1988) proposed Early Wisconsin for the Loveland/Sicily Island. McKay and Follmer (1985) suggested this loess correlated with a loess under Illinoian till. Clark et al. (1989) agreed on Crowley's Ridge, but suggested the Loveland/Sicily Island loess on Sicily Island was older. Mirecki and Miller (1994) and Millard and Maat (1994) suggested an Illinoian age for the Loveland/Sicily Island loess. Miller and co-workers suggested, as did Pye and Johnson (1988), an Illinoian age for the Crowley's Ridge loess. McKay and Follmer (1985) suggested it correlated with a loess under "Kansan" till. Stratigraphy indicates the Marianna is the older of the five loesses. Researchers identified loess on both the east and west side of the LMV as well as on higher terraces within the valley. Many researchers assumed unaltered loesses were commonly yellowish brown, and silts or silt loams (West et al., 1980; Miller et al., 1986). The nonclay fraction of unweathered LMV loesses was dominated by quartz followed by carbonates, mainly dolomites, followed by feldspars, and micas. Clays were dominated by montmorillonite followed by micaceous minerals, kaolinite and vermiculite (Miller et al., 1986). Soils in the Crowley's Ridge loess are most developed, followed by the soils in the Loveland/Sicily Island which are more developed than the modern soils in the Peoria Loess. Soils in the Roxana and Marianna loesses are least developed and the Farmdale Soil of the Roxana is the weaker of the two (Miller et al., 1986). There is certainly overlapping range in the degree of soil development in the various loesses.

The F-16 Onboard Oxygen Generating System: Performance Evaluation and Man Rating

DTIC Science & Technology

1983-08-01

OXYGEN GENERATING , YSTEM: PERFORMANCE EVALUATION AND MAN RATING Thomas C. Horch , Captain, USAF Richard L. Miller, Ph.D. John B. Bomar, Jr...C. Horch , Capt, USAF; R. L. Miller, 8. CONTRACT OR GRANT NUMBER(i) Ph.D.; J. B. Bomar, Jr., Lt Col, IJSAF, BSC; J. B. Tedor, Maj, USAF, BSC; R. D...limitation (as of 1983); however, the information may no longer need protection since it is 14 years. At the time of its publication, Capt Thomas Horch

Wide Area Recovery and Resiliency Program (WARRP) Knowledge Enhancement Events: Damage Assessment Building Abandonment After Action Report

DTIC Science & Technology

2012-04-17

nitrate / Fuel oil (ANFO). The explosive and the shielded CsCl sources are packaged into bombs and loaded onto a truck. The total explosive yield in...Transportation Eric Jacobs State of Colorado Laura Johnston Dewberry Carl Miller Colorado Springs OEM John Miller American Red Cross Matthew...the health effects of the contamination will be. Scenario Terrorist obtain approximately 2,300 curies of 137 Cs (CsCl), and 1.5 tons of Ammonium

A Method for Estimating Missing Hourly Temperatures Using Daily Maximum and Minimum Temperatures

DTIC Science & Technology

1991-08-01

work documented by USAFETAC/PR-90/006, S/urt-Termn Hourl ’y Iernpcrature Interlyolaion, by Mal Wvalter F . Miller, December 1990. In his study, Miller...temperatures for the missing hours and concluded that the best model %as one developed by Hoogenboom and [luck (1986). The Hoogcnboom/Huck model uses a...mean of the error estimate, was determined from the following equation: - 7)) BIAS = 1 N", f (14) where the difference between the observed hourly

Advanced Polymers for Practical Use

NASA Technical Reports Server (NTRS)

1999-01-01

Resulting from a SBIR contract with the Goddard Space Flight Center, Foster-Miller developed a high performance, low cost substrate for printed circuits with a coefficient of thermal expansion (CTE) matched to the surface mounted devices. The commercial product that resulted from the agreement between the two organizations was so successful that Foster-Miller created a spin-off company named Superex, Inc., devoted solely to the promotion of this particular substrate. The contract originated from NASA's need to develop better, more cost effective satellite and land based electronic applications.

Why there is no supernatural morality: response to Miller's opening statement.

PubMed

Shermer, Michael

2016-11-01

If one is going to argue that objective morality depends on an Archimedean point outside the natural world, then it would seem to imply that this source is necessarily supernatural. Thus, Christian Miller begins by defining precisely who he thinks this supernatural moral law giver is: the omniscient, omnipotent, and omnibenevolent creator of the universe who is still actively involved with human affairs-Elohim, Jehovah, Yahweh, or Allah-aka God. Already I'm skeptical. © 2016 New York Academy of Sciences.

Aerodynamics of Rotorcraft (L’Aerodynamique des Aeronefs a Voilure Tournante)

DTIC Science & Technology

1990-11-01

appreciate wether or not the airfoil drag was liable to differ significantly from the 2-D value imposed In the CAMRAD calculation. Rotor blade boundary layer...0079, 1986 24. P.G. Wilby, M.J. Riley, Judith Miller, "Some unsteady effects on helicopter rotors." 7th European Rotorcraft and Powered Lift Forum...1981 W b 9-20 25. H.J. Riley, Judith Miller, "Pressure distributions on a helicopter swept tip from flight tests and from calculations", Paper No 9, 9th

Moving finite elements in 2-D

NASA Technical Reports Server (NTRS)

Gelinas, R. J.; Doss, S. K.; Vajk, J. P.; Djomehri, J.; Miller, K.

1983-01-01

The mathematical background regarding the moving finite element (MFE) method of Miller and Miller (1981) is discussed, taking into account a general system of partial differential equations (PDE) and the amenability of the MFE method in two dimensions to code modularization and to semiautomatic user-construction of numerous PDE systems for both Dirichlet and zero-Neumann boundary conditions. A description of test problem results is presented, giving attention to aspects of single square wave propagation, and a solution of the heat equation.

NMR Imaging of Elastomeric Materials

DTIC Science & Technology

1992-08-31

1991, 10, 59. (Ill Cory, D.G., Miller, J.B., 7Turner, R., Garroway , A.N., Mol. Phys. 1990, 70, 331-7 [121 Jezzard, P., Carpenter, T.A., Hall, L.D.{Polym...SPE Paper 18272, 63rd Annual Technical Conference and Exhibition, Houston, TX, Oct. 2-5, 1988. 9. D.G. Cory, J.B. Miller, R. Turner, and A.N. Garroway ...B.; Turner, R.; Garroway , A. N. Mol. as the cause of the arrowhead artifacts. We thank An- Phys. I", 70, 331. nadell Fowler and John Pearce for

Our Loss Was Heavy: Brigadier General Josiah Harmar’s Kekionga Campaign of 1790

DTIC Science & Technology

2015-05-23

visiting forts, and perusing niche museums around the world instead of lounging on the beach during the ever too few leave periods. I am ever grateful for...forcing the Algonquian people to shape a new existence26 Other authors such as Eric Hinderaker, Gregory H. Nobles, and Sarah E . Miller further expand...Frontiers: Cultural Encounters and Continental Conquest (New York: Hill and Wang, 1997), 15. Likewise, Sarah E . Miller notes that the United States

Atmospheric Effects for Ground Target Signature Modeling. 3. Discussion and Application of the ASL Scattering Model

DTIC Science & Technology

1975-03-01

Veazey , "An Integrated Error Description of Active and Passive Balloon Tracking Systems," ECOM-5500, June 1973. 18. Doll, Barry, "The Potential Use...Effect of Viewing Angle on the Ground Resolution of Satellite-Borne Sensors," ECOM-5502, July 1973. 20. Miller, Walter B., and Donald R. Veazey ...60. Miller, Walter B., and Donald R. Veazey , "On Increasing Vertical Efficiency of a Passive Balloon Tracking Device by Optimal Choice of

JPL Researcher Tim Miller at the primary AirSAR station aboard NASA's DC-8 flying laboratory during the AirSAR 2004 campaign

NASA Image and Video Library

2004-03-03

JPL Researcher Tim Miller at the primary AirSAR station aboard NASA's DC-8 flying laboratory during the AirSAR 2004 campaign. AirSAR 2004 is a three-week expedition by an international team of scientists that will use an all-weather imaging tool, called the Airborne Synthetic Aperture Radar (AirSAR), in a mission ranging from the tropical rain forests of Central America to frigid Antarctica.

A new species of Agaporomorphus Zimmermann, 1921 from Peru (Coleoptera, Dytiscidae, Copelatinae)

PubMed Central

Hendrich, Lars; Apenborn, Rico; Burmeister, Ernst-Gerhard; Balke, Michael

2015-01-01

Abstract Agaporomorphus julianeae sp. n. is described from the Biological Field Station Panguana, in Huànuco province of central Peru. The new species belongs to the Agaporomorphus knischi-group sensu Miller 2005. Together with Agaporomorphus knischi Zimmermann, 1921 and Agaporomorphus colberti Miller & Wheeler, 2008 this is the third species of the genus with broadly enlarged male antennomeres. The new species can be separated from Agaporomorphus colberti and Agaporomorphus knischi by the smaller please expanded male antennomere VIII, and the form of the median lobe. Important species characters (median lobe, male antennae, metafemur, colour pattern) of the new species and Agaporomorphus knischi are figured, and the habitat, a temporary blackwater forest pond, and its species rich water beetle coenosis are illustrated and described in detail. The Brazilian Agaporomorphus mecolobus Miller, 2001, only known from the type material from Sao Paulo, is here recorded for Minas Gerais. Habitus photos of four additional Agaporomorphus species and Hydrodytes opalinus (Zimmermann, 1921) are provided. Altogether ten species of Agaporomorphus are now known. PMID:26257560

Treatment of multiple adjacent Miller Class I and II gingival recessions with collagen matrix and the modified coronally advanced tunnel technique.

PubMed

Molnár, Bálint; Aroca, Sofia; Keglevich, Tibor; Gera, István; Windisch, Péter; Stavropoulos, Andreas; Sculean, Anton

2013-01-01

To clinically evaluate the treatment of Miller Class I and II multiple adjacent gingival recessions using the modified coronally advanced tunnel technique combined with a newly developed bioresorbable collagen matrix of porcine origin. Eight healthy patients exhibiting at least three multiple Miller Class I and II multiple adjacent gingival recessions (a total of 42 recessions) were consecutively treated by means of the modified coronally advanced tunnel technique and collagen matrix. The following clinical parameters were assessed at baseline and 12 months postoperatively: full mouth plaque score (FMPS), full mouth bleeding score (FMBS), probing depth (PD), recession depth (RD), recession width (RW), keratinized tissue thickness (KTT), and keratinized tissue width (KTW). The primary outcome variable was complete root coverage. Neither allergic reactions nor soft tissue irritations or matrix exfoliations occurred. Postoperative pain and discomfort were reported to be low, and patient acceptance was generally high. At 12 months, complete root coverage was obtained in 2 out of the 8 patients and 30 of the 42 recessions (71%). Within their limits, the present results indicate that treatment of Miller Class I and II multiple adjacent gingival recessions by means of the modified coronally advanced tunnel technique and collagen matrix may result in statistically and clinically significant complete root coverage. Further studies are warranted to evaluate the performance of collagen matrix compared with connective tissue grafts and other soft tissue grafts.

Familial pachygyria in both genders related to a DCX mutation.

PubMed

Kim, Young Ok; Nam, Tai-Seung; Park, Chungoo; Kim, Seul Kee; Yoon, Woong; Choi, Seok-Yong; Kim, Myeong-Kyu; Woo, Young Jong

2016-06-01

Doublecortin (DCX) and tubulin play critical roles in neuronal migration. DCX mutations usually cause anterior dominant lissencephaly in males and subcortical band heterotopia (SBH) in females. We used whole-exome sequencing to investigate causative gene variants in a large family with late-childhood-onset focal epilepsy and anterior dominant pachygyria without SBH in both genders. Two potential variants were found for the genes encoding DCX and beta tubulin isotype 1 (TUBB1). The novel DCX mutation (p.D90G, NP_000546.2) appeared to be a major causative variant, whereas the novel mutation of TUBB1 (p.R62fsX, NP_110400.1) was found only in patients with more-severe intellectual disability after gender matching. We report an unusual DCX-related disorder exhibiting familial pachygyria without SBH in both genders. Copyright © 2015 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

Visualization of migration of human cortical neurons generated from induced pluripotent stem cells.

PubMed

Bamba, Yohei; Kanemura, Yonehiro; Okano, Hideyuki; Yamasaki, Mami

2017-09-01

Neuronal migration is considered a key process in human brain development. However, direct observation of migrating human cortical neurons in the fetal brain is accompanied by ethical concerns and is a major obstacle in investigating human cortical neuronal migration. We established a novel system that enables direct visualization of migrating cortical neurons generated from human induced pluripotent stem cells (hiPSCs). We observed the migration of cortical neurons generated from hiPSCs derived from a control and from a patient with lissencephaly. Our system needs no viable brain tissue, which is usually used in slice culture. Migratory behavior of human cortical neuron can be observed more easily and more vividly by its fluorescence and glial scaffold than that by earlier methods. Our in vitro experimental system provides a new platform for investigating development of the human central nervous system and brain malformation. Copyright © 2017 Elsevier B.V. All rights reserved.

Spatio-Temporal Characteristics of Scalar Mixing and Dissipation Processes in Turbulent Jets and Flames

DTIC Science & Technology

2012-11-20

Wadham, T., Holden, M., Danehy, P.M., “NO PLIF Imaging in the CUBRC 48-Inch Shock Tunnel,” online, Experiments in Fluids, 2012, DOI: 10.1007/s00348...Lempert, W.R., Miller, J.D., Meyer, T.R., Parker, R., Wadham, T., Holden, M., Danehy, P.M., “NO PLIF Imaging in the CUBRC 48-Inch Shock Tunnel...Patton, R., Sutton, J.A., Lempert, W., Miller, J., Meyer, T., Parker, R., Danehy, P., “NO PLIF Imaging in the CUBRC 48” Shock Tunnel”, 49th

Defending the Frontier: A Study of the U.S. Army in the Defense of the Nebraska Frontier in the Years 1849-1853.

DTIC Science & Technology

1984-12-12

its long waiting periods, in this case waiting for a ship to pick you up on the Pacific side of the Isthmus. Malaria , yellow fever, poor sanitation...travelers of the prairie include the following: whooping cough, measles, mumps, smallpox, malaria , dysentery, delirium tremens, pneumonia, toothache, and...U.S., Senate, " Statistcal Report", p. 79 S. V. Miller, "Copy of a letter written by S. V. Miller to his parents from Salem, Oregon, November 24, 1852

User satisfaction and forces generated during laryngoscopy using disposable Miller blades: a manikin study.

PubMed

Sudhir, G; Wilkes, A R; Clyburn, P; Aguilera, I; Hall, J E

2007-10-01

Increasing awareness of prion-related diseases has led to an increase in the number of disposable laryngoscope blades available. We compared 11 disposable and standard re-usable Miller size 1 blades. In this manikin-based study, we studied user satisfaction for field of view at laryngoscopy, build quality and users' willingness to use the blade in an emergency situation. These were found to be better with metal disposable blades (p

Progress in Understanding the Impacts of 3-D Cloud Structure on MODIS Cloud Property Retrievals for Marine Boundary Layer Clouds

NASA Technical Reports Server (NTRS)

Zhang, Zhibo; Werner, Frank; Miller, Daniel; Platnick, Steven; Ackerman, Andrew; DiGirolamo, Larry; Meyer, Kerry; Marshak, Alexander; Wind, Galina; Zhao, Guangyu

2016-01-01

Theory: A novel framework based on 2-D Tayler expansion for quantifying the uncertainty in MODIS retrievals caused by sub-pixel reflectance inhomogeneity. (Zhang et al. 2016). How cloud vertical structure influences MODIS LWP retrievals. (Miller et al. 2016). Observation: Analysis of failed MODIS cloud property retrievals. (Cho et al. 2015). Cloud property retrievals from 15m resolution ASTER observations. (Werner et al. 2016). Modeling: LES-Satellite observation simulator (Zhang et al. 2012, Miller et al. 2016).

Initial results of experimental studies of prairie dogs in arid grasslands: Implications for landscape conservation and the importance of scale (Resultados Iniciales de Estudios Experimentales en Perros Llaneros de Pastizales Aridos: Implicaciones Para la Conservacion del Paisaje y la Importancia de Escala)

Treesearch

Charles Curtin

2006-01-01

Numerous ecologists and conservationists believe that prairie dogs increase ecosystem diversity and preserve the function of grasslands (Whicker and Detling 1988, Miller et al. 1994, Jones et al. 1994, Power et al. 1996, Weltzin et al. 1997, Miller et al. 2000), yet this perspective is controversial (Stapp 1998). In contrast, many ranchers and land owners view prairie...

NMR Studies of Organic Thin Films

DTIC Science & Technology

1993-05-15

Fiins - 53 125. C.G. Chingas, J.B. Miller, and A.N. Garroway , J. Magn. Reson., 1986, 66, 530. 126. D.G. Cory, J.W.M. van Os, and W.S. Veeman, J. Magn...24, 5294. 130. N. Zumbulyadis and J.M. O’Reilly, J. Magn. Reson., 1989, 82, 613. 131. H.A. Resing, A.N. Garroway , D.C. Weber, J. Ferrais, and D...4, 182. 136. A. Natansohn, Polym. Eng. Sci., 1992, 32, 1711. 137. J.B. Miller and A.N. Garroway , J. Magn. Reson., 1989, 82, 529. 138. D.G. Cory, J.B

Reduction of 5in./54 Gun Blast Overpressure by Means of an Aqueous Foam- Filled Muzzle Device

DTIC Science & Technology

1981-08-01

aqueous foams have a certain drainage rate that causes the expansion ratio and bubble size to increase progressively. The Rockwood Aquafoam AFFF yields the...NSWC TR 81-128 REDUCTION OF 5"/54 GUN BLAST OVERPRESSURE BY MEANS OF AN AQUEOUS FOAM -FILLED MUZZLE DEVICE by G. STEVENS MILLER RICHARD E. MILLER, JR...128 4. TITLE (ad Subtitle) S. TYPE O r REPORT & PERIOD COVERED REDUCTION OF 5!V54 GUN BLAST OVERPRESSURE Final BY MEANS OF AN AQUEOUS FOAM -FILLED a

William Allen Miller (1817-70): a distinguished scientist re-discovered.

PubMed

Ashley-Miller, Michael

2008-11-01

Dr William Allen Miller developed an early interest in science and astronomy at secondary school. Although qualifying in medicine, he pursued a career in Chemistry at King's College, London. A particular interest in spectrum analysis led to a collaboration with Dr Huggins in examining the spectra of stars. For this work they each received the Gold Medal of the Royal Astronomical Society. His subsequent work at King's College, the Royal Society, the Courts of Law and for various Government enterprises earned him an outstanding scientific and advisory reputation.

The pursuit of immortality: from the ego to the soul.

PubMed

Miller, Lisa; Miller, Kenneth; Haught, John; Murphy, Nancey

2011-10-01

Moderated by Lisa Miller from Newsweek, evolutionary biologist Kenneth Miller (Brown University) and theologians John Haught (Georgetown University) and Nancey Murphy (Fuller Theological Seminary) discuss the questions Are we immortal? Do our souls exist beyond our bodies? and What scientific evidence is there for mystical experience? from a cultural, historical, and scientific perspective. The following is an edited transcript of the discussion that occurred March 23, 2011, 7:00-8:15 PM, at the New York Academy of Sciences in New York City. © 2011 New York Academy of Sciences.

New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum.

PubMed

Bahi-Buisson, Nadia; Souville, Isabelle; Fourniol, Franck J; Toussaint, Aurelie; Moores, Carolyn A; Houdusse, Anne; Lemaitre, Jean Yves; Poirier, Karine; Khalaf-Nazzal, Reham; Hully, Marie; Leger, Pierre Louis; Elie, Caroline; Boddaert, Nathalie; Beldjord, Cherif; Chelly, Jamel; Francis, Fiona

2013-01-01

X-linked isolated lissencephaly sequence and subcortical band heterotopia are allelic human disorders associated with mutations of doublecortin (DCX), giving both familial and sporadic forms. DCX encodes a microtubule-associated protein involved in neuronal migration during brain development. Structural data show that mutations can fall either in surface residues, likely to impair partner interactions, or in buried residues, likely to impair protein stability. Despite the progress in understanding the molecular basis of these disorders, the prognosis value of the location and impact of individual DCX mutations has largely remained unclear. To clarify this point, we investigated a cohort of 180 patients who were referred with the agyria-pachygyria subcortical band heterotopia spectrum. DCX mutations were identified in 136 individuals. Analysis of the parents' DNA revealed the de novo occurrence of DCX mutations in 76 cases [62 of 70 females screened (88.5%) and 14 of 60 males screened (23%)], whereas in the remaining cases, mutations were inherited from asymptomatic (n = 14) or symptomatic mothers (n = 11). This represents 100% of families screened. Female patients with DCX mutation demonstrated three degrees of clinical-radiological severity: a severe form with a thick band (n = 54), a milder form (n = 24) with either an anterior thin or an intermediate thickness band and asymptomatic carrier females (n = 14) with normal magnetic resonance imaging results. A higher proportion of nonsense and frameshift mutations were identified in patients with de novo mutations. An analysis of predicted effects of missense mutations showed that those destabilizing the structure of the protein were often associated with more severe phenotypes. We identified several severe- and mild-effect mutations affecting surface residues and observed that the substituted amino acid is also critical in determining severity. Recurrent mutations representing 34.5% of all DCX mutations often lead to similar phenotypes, for example, either severe in sporadic subcortical band heterotopia owing to Arg186 mutations or milder in familial cases owing to Arg196 mutations. Taken as a whole, these observations demonstrate that DCX-related disorders are clinically heterogeneous, with severe sporadic and milder familial subcortical band heterotopia, each associated with specific DCX mutations. There is a clear influence of the individual mutated residue and the substituted amino acid in determining phenotype severity.

The Microcosm within: An interview with William B. Miller, Jr., on the Extended Hologenome theory of evolution.

PubMed

Hunt, Tam

2015-01-01

There is a singular unifying reality underlying every biologic interaction on our planet. In immunology, that which does not kill you makes you different. -William B. Miller, Jr. We are experiencing a revolution in our understanding of inner space on a par with our exponentially increasing understanding of outer space. In biology, we are learning that the genetic and epigenetic complexity within organisms is far deeper than suspected. This is a key theme in William B. Miller Jr.'s book, The Microcosm Within: Evolution and Extinction in the Hologenome. We are learning also that a focus on the human genome alone is misleading when it comes to who we really are as biological entities, and in terms of how we and other creatures have evolved. Rather than being defined by the human genome alone, we are instead defined by the "hologenome," the sum of the human genome and the far larger genetic endowment of the microbiome and symbiotic communities that reside within and around us. Miller is a medical doctor previously in private practice in Pennsylvania and Phoenix, Arizona. This book is his first foray into evolutionary theory. His book could have been titled "The Origin of Variation" because this is his primary focus. He accepts that natural selection plays a role in evolution, but he demotes this mechanism to a less important role than the Modern Synthesis suggests. His main gripe, however, concerns random variation. He argues that random variation is unable to explain the origin and evolution of biological forms that we see in the world around us and in the historical record. Miller suggests that, rather than random variation as the engine of novelty, there is a creative impulse at the heart of cellular life, and even at the level of the genetic aggregate, that generates novelty on a regular basis. I probe this assertion in the interview below. He also highlights the strong role of "exogenous genetic assault" in variation and in his immunological model of evolution.

Stochastic Particle Acceleration in Impulsive Solar Flares

NASA Technical Reports Server (NTRS)

Miller, James A.

2001-01-01

The acceleration of a huge number of electrons and ions to relativistic energies over timescales ranging from several seconds to several tens of seconds is the fundamental problem in high-energy solar physics. The cascading turbulence model we have developed has been shown previously (e.g., Miller 2000; Miller & Roberts 1995; Miner, LaRosa, & Moore 1996) to account for all the bulk features (such as acceleration timescales, fluxes, total number of energetic particles, and maximum energies) of electron and proton acceleration in impulsive solar flares. While the simulation of this acceleration process is involved, the essential idea of the model is quite simple, and consists of just a few parts: 1. During the primary flare energy release phase, we assume that low-amplitude MHD Alfven and fast mode waves are excited at long wavelengths, say comparable to the size of the event (although the results are actually insensitive to this initial wavelength). While an assumption, this appears reasonable in light of the likely highly turbulent nature of the flare. 2. These waves then cascade in a Kolmogorov-like fashion to smaller wavelengths (e.g., Verma et al. 1996), forming a power-law spectral density in wavenumber space through the inertial range. 3. When the mean wavenumber of the fast mode waves has increased sufficiently, the transit-time acceleration rate (Miller 1997) for superAlfvenic electrons can overcome Coulomb energy losses, and these electrons are accelerated out of the thermal distribution and to relativistic energies (Miller et al. 1996). As the Alfven waves cascade to higher wavenumbers, they can cyclotron resonate with progressively lower energy protons. Eventually, they will resonate with protons in the tail of the thermal distribution, which will then be accelerated to relativistic energies as well (Miller & Roberts 1995). Hence, both ions and electrons are stochastically accelerated, albeit by different mechanisms and different waves. 4. When the protons become superAlfvenic (above about 1 MeV/nucleon), they too can suffer transit-time acceleration by the fast mode waves and will receive an extra acceleration "kick." The basic overall objective of this 1 year effort was to construct a spatially-dependent version of this acceleration model and this has been realized.

Estimating energy expenditure in vascular surgery patients: Are predictive equations accurate enough?

PubMed

Suen, J; Thomas, J M; Delaney, C L; Spark, J I; Miller, M D

2016-12-01

Malnutrition is prevalent in vascular surgical patients who commonly seek tertiary care at advanced stages of disease. Adjunct nutrition support is therefore pertinent to optimise patient outcomes. To negate consequences related to excessive or suboptimal dietary energy intake, it is essential to accurately determine energy expenditure and subsequent requirements. This study aims to compare resting energy expenditure (REE) measured by indirect calorimetry, a commonly used comparator, to REE estimated by predictive equations (Schofield, Harris-Benedict equations and Miller equation) to determine the most suitable equation for vascular surgery patients. Data were collected from four studies that measured REE in 77 vascular surgery patients. Bland-Altman analyses were conducted to explore agreement. Presence of fixed or proportional bias was assessed by linear regression analyses. In comparison to measured REE, on average REE was overestimated when Schofield (+857 kJ/day), Harris-Benedict (+801 kJ/day) and Miller (+71 kJ/day) equations were used. Wide limits of agreement led to an over or underestimation from 1552 to 1755 kJ. Proportional bias was absent in Schofield (R 2  = 0.005, p = 0.54) and Harris-Benedict equations (R 2  = 0.045, p = 0.06) but was present in the Miller equation (R 2  = 0.210, p < 0.01) even after logarithmic transformation (R 2  = 0.213, p < 0.01). Whilst the Miller equation tended to overestimate resting energy expenditure and was affected by proportional bias, the limits of agreement and mean bias were smaller compared to Schofield and Harris-Benedict equations. This suggested that it is the preferred predictive equation for vascular surgery patients. Future research to refine the Miller equation to improve its overall accuracy will better inform the provision of nutritional support for vascular surgery patients and subsequently improve outcomes. Alternatively, an equation might be developed specifically for use with vascular surgery patients. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

Correlation between response to neoadjuvant chemotherapy and survival in locally advanced breast cancer patients.

PubMed

Romero, A; García-Sáenz, J A; Fuentes-Ferrer, M; López Garcia-Asenjo, J A; Furió, V; Román, J M; Moreno, A; de la Hoya, M; Díaz-Rubio, E; Martín, M; Caldés, T

2013-03-01

Measurement of residual disease following neoadjuvant chemotherapy that accurately predicts long-term survival in locally advanced breast cancer (LABC) is an essential requirement for clinical trials development. Several methods to assess tumor response have been described. However, the agreement between methods and correlation with survival in independent cohorts has not been reported. We report survival and tumor response according to the measurement of residual breast cancer burden (RCB), the Miller and Payne classification and the Response Evaluation Criteria in Solid Tumors (RECIST) criteria, in 151 LABC patients. Kappa Cohen's coefficient (К) was used to test the agreement between methods. We assessed the correlation between the treatment outcome and overall survival (OS) and relapse-free survival (RFS) by calculating Harrell's C-statistic (c). The agreement between Miller and Payne classification and RCB classes was very high (К = 0.82). In contrast, we found a moderate-to-fair agreement between the Miller and Payne classification and RECIST criteria (К = 0.52) and RCB classes and RECIST criteria (К = 0.38). The adjusted C-statistic to predict OS for RCB index (0.77) and RCB classes (0.75) was superior to that of RECIST criteria (0.69) (P = 0.007 and P = 0.035, respectively). Also, RCB index (c = 0.71), RCB classes (c = 0.71) and Miller and Payne classification (c = 0.67) predicted better RFS than RECIST criteria (c = 0.61) (P = 0.005, P = 0.006 and P = 0.028, respectively). The pathological assessment of tumor response might provide stronger prognostic information in LABC patients.

Nest spacing, habitat selection, and behavior of waterfowl on Miller Lake Island, North Dakota

USGS Publications Warehouse

Lokemoen, J.T.; Duebbert, H.F.; Sharp, D.E.

1984-01-01

The nesting behavior of a concentration of nesting mallards (Anas platyrhynchos) and gadwalls (A. strepera) was studied on a 4.5-ha island in Miller Lake, North Dakota, in 1977. A single 0.59-ha clump of thick shrub contained 225 simultaneously active mallard nests on 10 May. During the peak nesting period, mallard nests were spaced an average of 2.7 m from conspecifics. Active nests of all species peaked at 327, spaced an average of 2.1 m apart. Nests were clustered in thick shrub with moderate numbers in open shrub and few in grassland. Nest placement was significantly related to the amount of vegetative screening although mammalian predators were absent on the island. Cover density appeared to be important to the nesting hens as vegetation screened nests from potential avian predators and from harassment by other conspecific nesting hens and drakes. Mallards and gadwalls nesting on this island used wetlands in >100 km2 around Miller Lake. During daylight hours in late April 1978, an average of 4.9 mallards/minute arrived at the island; a peak of 17.2 mallards/minute arrived at 0800. In late April 1978, as many as 26 mallard pairs/ha occurred on favored wetlands and behavioral aggression was intense. Yet, most mallard hens maintained adequate space to acquire food and other requisites. Mallards and gadwalls were sufficiently adaptable to successfully exploit the Miller Lake island and environments that resulted in high reproductive success. Other local breeding Anatidae because of behavioral constraints were unable to exploit the same situation.

Clinical evaluation and comparison of the efficacy of coronally advanced flap alone and in combination with platelet rich fibrin membrane in the treatment of Miller Class I and II gingival recessions

PubMed Central

Gupta, Santosh; Banthia, Ruchi; Singh, Pallavi; Banthia, Priyank; Raje, Sapna; Aggarwal, Neha

2015-01-01

Background: The aim of this study was to compare the clinical efficacy of coronally advanced flap (CAF) alone and in combination with autologous platelet rich fibrin membrane (PRF) in Miller's class I and II gingival recessions. Materials and Method: Thirty isolated Miller class I or II sites in 26 subjects were randomly divided into test (15 sites- CAF+PRF) and control (15 sites- CAF alone). Parameters probing pocket depth (PPD), Recession depth (RD), Clinical attachment loss (CAL), Keratinised tissue width (KTW) and Gingival tissue thickness (GTH) were evaluated at baseline, 3 months and 6 months postoperatively. Data was subjected to statistical analysis. P< 0.05 was considered statistically significant. Results: Mean percentage root coverage was 91.00±19.98% and 86.60±23.83% for test and control group respectively. Difference between the groups in all parameters at baseline, 3 months and 6 months was non significant. Complete root coverage was obtained in 12 (80%) and 11 (73.3%) subjects in test and control group respectively. The difference was found to be non-significant. Both groups showed significant differences in all parameters at 3 and 6 months respectively except difference in gingival tissue thickness which was non-significant in control group at 3 months. Conclusion: Combination of PRF to CAF procedure did not provide any added advantage in term of recession coverage in Miller class I and II recessions. Long term trials with more sample size are needed to validate these findings. PMID:26097347

Firearms and health: the right to be armed with accurate information about the Second Amendment.

PubMed Central

Vernick, J S; Teret, S P

1993-01-01

An organized campaign by groups such as the National Rifle Association has sought to convince policymakers and others that the Second Amendment to the US Constitution grants an unfettered right to individuals to possess any firearm, free from federal or state regulation. Although advocates may debate the meaning that should be given to the Second Amendment, under the American legal system the meaning of any particular constitutional provision is determined by the controlling precedent of Supreme Court cases. Two cases, Presser v Illinois and United States v Miller, remain the Supreme Court's latest word on the meaning of the Second Amendment. In Presser, the Court held that the Second Amendment is applicable only to federal, not state, laws. In Miller and subsequent federal cases, any Second Amendment "right" to bear arms is closely linked to the preservation of state militias, upholding a variety of federal gun legislation. Unless the Supreme Court modifies or reverses its Presser and Miller decisions, health advocates should understand that the Second Amendment poses no obstacle to even broad gun control legislation. PMID:8259817

Comparison of the Pentax, Truview, GlideScope, and the Miller laryngoscope for child intubation during resuscitation.

PubMed

Szarpak, Łukasz; Czyżewski, Łukasz; Kurowski, Andrzej

2015-03-01

The study was designed to compare the effectiveness of 3 video laryngoscopes with the Miller laryngoscope during pediatric resuscitation. This was a randomized crossover study involving 87 paramedics and 54 nurses. The primary end point of the study was the success rate of blind tracheal intubation, whereas the secondary end point was defined as the time from insertion of a device to the first manual ventilation of the manikin's lungs. The median time to intubation using the Pentax, Truview, GlideScope, and Miller varied with the times being 20.6 (interquartile range [IQR], 18-27) vs 20.1 (IQR, 18-23.3) vs 30.2 (IQR, 29.6-35) vs 41.3 (IQR, 33-45.2) seconds, respectively. The overall success ratios of intubation for the devices were 100% vs 100% vs 100% vs 79.4%. We concluded that, in a pediatric manikin scenario, the video laryngoscopes are safe devices and can be used for pediatric intubation during uninterrupted chest compressions. Further clinical studies are necessary to confirm these initial positive findings. Copyright © 2015 Elsevier Inc. All rights reserved.

A future for models?

NASA Astrophysics Data System (ADS)

Posey, C. J.

During times when overshot and undershot water wheels provided power for turning millstones, much depended upon the miller's judgment. “A big order is coming in tomorrow. Better shut down this afternoon. The trash rack needs to be cleaned and the flash boards raised.” Common sense could solve most of the problems in those days. It had to, if business was to continue.As the industrial revolution progressed, generation of electricity became a possibility. Higher rotational speeds than could be obtained by belts, pulleys, or gears were needed. Ingenious though the miller might have been, he had to depend on engineers who understood electricity and high-velocity flow to mate water wheels to dynamos. Enough engineers did, and by making tests of a variety of designs, often with small-scale runners, were able to guarantee the efficiency of hydroelectric generators suitable for a variety of sites. The miller was thus relieved of the “high-tech” decision. Now all important decisions fall to his successors, the utility companies, with assistance(?) from the State Utilities Boards and the National Securities and Exchange Commission.

Managed care plan performance since 1980: another look at 2 literature reviews.

PubMed Central

Sullivan, K

1999-01-01

OBJECTIVES: This article compares the quality of care provided by managed care plans (MCPs) and indemnity (or fee-for-service [FFS]) plans since 1980. METHODS: The 44 studies examined are the studies that Miller and Luft cited in their 1994 and 1997 reviews of the literature comparing MCPs with FFS plans. These studies are examined to determine how well they met Miller and Luft's selection criteria and, in addition, whether they controlled for differences in the breadth of insurance coverage. RESULTS: The 44 studies generated 57 observations. MCPs scored better than FFS plans on 10 of these, equally well on 25, and worse on 22. However, only 44 of these observations met the Miller-Luft criteria plus the coverage criterion. Four of these indicated that MCP care was better, 19 that MCP and FFS care were equivalent, and 21 that MCP care was worse. CONCLUSIONS: The small body of reliable studies comparing the quality of MCP care with that of FFS care indicates that the quality of care provided by MCPs tends to be equal or inferior to that provided by FFS plans. PMID:10394307

Burton-Miller-type singular boundary method for acoustic radiation and scattering

NASA Astrophysics Data System (ADS)

Fu, Zhuo-Jia; Chen, Wen; Gu, Yan

2014-08-01

This paper proposes the singular boundary method (SBM) in conjunction with Burton and Miller's formulation for acoustic radiation and scattering. The SBM is a strong-form collocation boundary discretization technique using the singular fundamental solutions, which is mathematically simple, easy-to-program, meshless and introduces the concept of source intensity factors (SIFs) to eliminate the singularities of the fundamental solutions. Therefore, it avoids singular numerical integrals in the boundary element method (BEM) and circumvents the troublesome placement of the fictitious boundary in the method of fundamental solutions (MFS). In the present method, we derive the SIFs of exterior Helmholtz equation by means of the SIFs of exterior Laplace equation owing to the same order of singularities between the Laplace and Helmholtz fundamental solutions. In conjunction with the Burton-Miller formulation, the SBM enhances the quality of the solution, particularly in the vicinity of the corresponding interior eigenfrequencies. Numerical illustrations demonstrate efficiency and accuracy of the present scheme on some benchmark examples under 2D and 3D unbounded domains in comparison with the analytical solutions, the boundary element solutions and Dirichlet-to-Neumann finite element solutions.

Hybrid Automotive Engine Using Ethanol-Burning Miller Cycle

NASA Technical Reports Server (NTRS)

Weinstein, Leonard

2004-01-01

A proposed hybrid (internal-combustion/ electric) automotive engine system would include as its internal-combustion subsystem, a modified Miller-cycle engine with regenerative air preheating and with autoignition like that of a Diesel engine. The fuel would be ethanol and would be burned lean to ensure complete combustion. Although the proposed engine would have a relatively low power-to-weight ratio compared to most present engines, this would not be the problem encountered if this engine were used in a non-hybrid system since hybrid systems require significantly lower power and thus smaller engines than purely internal-combustion-engine-driven vehicles. The disadvantage would be offset by the advantages of high fuel efficiency, low emission of nitrogen oxides and particulate pollutants, and the fact that ethanol is a renewable fuel. The original Miller-cycle engine, named after its inventor, was patented in the 1940s and is the basis of engines used in some modern automobiles, but is not widely known. In somewhat oversimplified terms, the main difference between a Miller-cycle engine and a common (Otto-cycle) automobile engine is that the Miller-cycle engine has a longer expansion stroke while retaining the shorter compression stroke. This is accomplished by leaving the intake valve open for part of the compression stroke, whereas in the Otto cycle engine, the intake valve is kept closed during the entire compression stroke. This greater expansion ratio makes it possible to extract more energy from the combustion process without expending more energy for compression. The net result is greater efficiency. In the proposed engine, the regenerative preheating would be effected by running the intake air through a heat exchanger connected to the engine block. The regenerative preheating would offer two advantages: It would ensure reliable autoignition during operation at low ambient temperature and would help to cool the engine, thereby reducing the remainder of the power needed for cooling and thereby further contributing to efficiency. An electrical resistance air preheater might be needed to ensure autoignition at startup and during a short warmup period. Because of the autoignition, the engine could operate without either spark plugs or glow plugs. Ethanol burns relatively cleanly and has been used as a motor fuel since the invention of internal-combustion engines. However, the energy content of ethanol per unit weight of ethanol is less than that of Diesel fuel or gasoline, and ethanol has a higher heat of vaporization. Because the Miller cycle offers an efficiency close to that of the Diesel cycle, burning ethanol in a Miller-cycle engine gives about as much usable output energy per unit volume of fuel as does burning gasoline in a conventional gasoline automotive engine. Because of the combination of preheating, running lean, and the use of ethyl alcohol, the proposed engine would generate less power per unit volume than does a conventional automotive gasoline engine. Consequently, for a given power level, the main body of the proposed engine would be bulkier. However, because little or no exhaust cleanup would be needed, the increase in bulk of the engine could be partially offset by the decrease in bulk of the exhaust system. The regenerative preheating also greatly reduces the external engine cooling requirement, and would translate to reduced engine bulk. It may even be possible to accomplish the remaining cooling of the engine by use of air only, eliminating the bulk and power consumption of a water cooling system. The combination of a Miller-cycle engine with regenerative air preheating, ethyl alcohol fuel, and hybrid operation could result in an automotive engine system that satisfies the need for a low pollution, high efficiency, and simple engine with a totally renewable fuel.

NASA Chief Technologist Douglas Terrier Tours Jacobs' Engineering Development Facility

NASA Image and Video Library

2017-08-10

NASA Chief Technologist Douglas Terrier joins Jacobs General Manager Lon Miller during a tour of the company's Engineering Development Facility in Houston. Jacobs provides advanced technologies used aboard the International Space Station and for deep space exploration. From left: NASA’s Johnson Space Center Chief Technologist Chris Culbert, Chief Technologist Douglas Terrier, Jacobs Clear Lake Group Deputy General Manager Joy Kelly and Jacobs Clear Lake Group General Manager Lon Miller. Date: 08-10-2017 Location: B1 & Jacobs Engineering Subject: NASA Acting Chief Technology Officer Douglas Terrier Tours JSC and Jacobs Photographer: David DeHoyos

Antioxidant and antimicrobial properties of Casteanea sativa Miller chestnut honey produced on Mount Etna (Sicily).

PubMed

Ronsisvalle, Simone; Lissandrello, Edmondo; Fuochi, Virginia; Petronio Petronio, Giulio; Straquadanio, Claudia; Crascì, Lucia; Panico, Annamaria; Milito, Marcella; Cova, Anna Maria; Tempera, Gianna; Furneri, Pio Maria

2017-12-13

The aim of this study was the evaluation of antibacterial and antioxidant properties of Monofloral Etna Castanea sativa Miller honeys. Escherichia coli ATCC 25,922, Pseudomonas aeruginosa ATCC 27,853, Enterococcus faecalis ATCC 29,211 and Staphylococcus aureus ATCC 29,213 were investigated for their susceptibilities to two different honeys. Antioxidant activity was evaluated by ORAC, NO scavenger assays, FRAP and DPPH. Antioxidant activity and antibacterial properties were compared with chestnut honeys from different geographical areas and with Manuka honey. UPLC-MS/MS was used for major components characterisation.

Photonic Analog-to-Digital Converter Preprocessing Using the Robust Symmetrical Number System for Direct Digitization of Antenna Signals

DTIC Science & Technology

2010-12-01

sample and hold circuit was reported by Urata et al. [6–9]. A 160 megasamples/s sampling rate with 3.5 ENOB was achieved using this design. The...2006. [6] R. Urata , L. Y. Nathawad, R. Takahashi, Kai Ma, D. A. B. Miller, B. A. Wooley and J. S. Harris Jr., “Photonic A/D conversion using low... Urata , R. Takahashi, V. A. Sabnis, D. A. B. Miller, and J. S. Harris Jr., “Ultrafast differential sample and hold using low-temperature-grown GaAs MSM

Informed Consent for Whole Genome Sequencing: A Qualitative Analysis of Participant Expectations and Perceptions of Risks, Benefits, and Harms

PubMed Central

Tabor, Holly K.; Stock, Jacquie; Brazg., Tracy; McMillin, Margaret J.; Dent., Karin M.; Yu, Joon-Ho; Shendure, Jay; Bamshad, Michael J.

2012-01-01

Scientific evidence on the extent to which ethical concerns about privacy, confidentiality, and return of results for whole genome sequencing (WGS) are effectively conveyed by informed consent (IC) is lacking. The aim of this study was to learn, via qualitative interviews, about participant expectations and perceptions of risks, benefits, and harms of WGS. Participants in two families with Miller syndrome consented for WGS were interviewed about their experiences of the IC process and their perceptions of risks, benefits, and harms of WGS. Interviews were transcribed and analyzed for common themes. IC documents are included in the supplementary materials. Participants expressed minimal concerns about privacy and confidentiality with regard to both their participation and sharing of their WGS data in restricted access databases. Participants expressed strong preferences about how results should be returned, requesting both flexibility of the results return process and options for the types of results to be returned. Participant concerns about risks to privacy and confidentiality from broad sharing of WGS data are likely to be strongly influenced by social and medical context. In these families with a rare Mendelian syndrome, the perceived benefits of participation strongly trumped concerns about risks. Individual preferences, for results return, even within a family, varied widely. This underscores the need to develop a framework for results return that allows explicitly for participant preferences and enables modifications to preferences over time. Web-based tools that facilitate participant management of their individual research results could accommodate such a framework. PMID:22532433

Annual Data Summary and Climatological Evaluation CERC (Coastal Engineering Research Center) Field Research Facility, 1985. Volume 1. Main Text and Appendixes A and B.

DTIC Science & Technology

1987-09-01

AD-AI6 442 ANNUAL DATA SUMMARY AND CLINATOLOGICAL EVALUATION CEC I/ (COASTAL ENGINEERI.. (U) COASTAL ENGINEERING RESEARCH CENTER VICKSBURG NS H C ...MILLER ET RL. SEP 87 UNL ASSIF IED C RC-TR-87-i-L-1 F/0G/3 Mmsomommosmsss EmhhhmmmmmhEhEshhhhEhBhhE .EhI-EllhhlhhI mll/I/I l/I/u -1 I.I I ’ 22 I 1.8...SUMMARY AND ofEgier CLIMATOLOGICAL EVALUATION CERC FIELD RESEARCH FACILITY, 1985 NVolume I MAIN TEXT AND APPENDIXES A AND B, by ,, U Herman C . Miller

Dissociative identity disorder: a feminist approach to inpatient treatment using Jean Baker Miller's Relational Model.

PubMed

Riggs, S R; Bright, M A

1997-08-01

Women diagnosed with Dissociative Identity Disorder (DID) may experience episodic crises characterized by intense states of disconnection from self and others. Crises which result in potential harm to self/others may require inpatient treatment. With economic emphasis on shorter lengths of stay, a treatment program or model which focuses on the DID patient's sense of connectedness to self and others can enhance treatment efforts during brief inpatient hospitalizations. The Relational Model of Jean Baker Miller uses mutuality and empowerment within the therapeutic relationship and inpatient mileu to move the patient beyond therapeutic impasse/crisis toward a state of greater connectedness to self and others.

The Chemistry of Early Self-Replicating Systems

NASA Technical Reports Server (NTRS)

Bada, Jeffrey L.

2004-01-01

On June 10, 2003, a symposium 'Celebrating 50 Years of Prebiotic Chemistry' honoring the 50th Anniversary of the 1953 publication of the Miller Experiment in SCIENCE was held at the University of California, San Diego. This event was organized and hosted by the NASA Specialized Center of Research and Training in Exobiology. It was sponsored by NASA, the Dean of Physical Sciences and the Department of Chemistry and Biochemistry at the University of California, San Diego (UCSD). The following events were held: 1) For the symposium, public lectures and a reception were held at UCSD on June 10, 2003 in honor of the 50th Anniversary of the Miller Experiment. The speakers were the NSCORT/Exobiology Principal Investigators Dr. Jeffrey L. Bada and Dr. Gerald F. Joyce and the moderator, Dr. Leslie Orgel; 2) A evening discussion seminar and dinner was held at UCSD with invited scientists, NSCORT investigators, NASA Headquarters Officials and the Chancellor and Officials of the University of California, San Diego. Stanley Miller has had a long history of support from the NASA Exobiology Section. This event commemorated the anniversary of his classic experiment and was a small recognition of his contributions to the field.

Analytical and numerical calculation of the second-order moment of the beam using a capacitive pickup

NASA Astrophysics Data System (ADS)

Tsemo Kamga, Joel Alain; Müller, Wolfgang F. O.; Weiland, Thomas

2016-04-01

Beam emittance has particular importance in particle physics, because it provides information about the quality of the particle beam. There are many techniques for measuring the beam emittance, such as that proposed by Miller et al. [Report No. SLAC-PUB-3186, (A) (1983)]. This technique is based on determining the emittance by measuring the second-order moment of the beam using quadrupole pickups consisting of four symmetrical electrodes placed around the beam pipe at 90° intervals, respectively. Based on Miller's approach, two signal processing methods are generally used to get the quadrupole moment of the beam, namely the difference over sum and the log ratio [P. Li et al., IEEE Nuclear Science Symposium Conference Record, N24-404, 2007, pp. 1675-1678] methods. However, these traditional methods provide results with a good accuracy only for a well centered beam. The method presented in this paper, which starts with Miller's approach, considerably reduces the impact of the dipole signal on the quadrupole moment measurement for both small and large values of the beam position. Furthermore, a methodology for the numerical determination of the sensitivity of quadrupole pickups will be presented.

DMRTA2 (DMRT5) is mutated in a novel cortical brain malformation.

PubMed

Urquhart, J E; Beaman, G; Byers, H; Roberts, N A; Chervinsky, E; O'Sullivan, J; Pilz, D; Fry, A; Williams, S G; Bhaskar, S S; Khayat, M; Simanovsky, N; Shachar, I B; Shalev, S A; Newman, W G

2016-06-01

Lissencephaly is a phenotypically and genetically heterogeneous group of cortical brain malformations due to abnormal neuronal migration. The identification of many causative genes has increased the understanding of normal brain development. A consanguineous family was ascertained with three siblings affected by a severe prenatal neurodevelopmental disorder characterised by fronto-parietal pachygyria, agenesis of the corpus callosum and progressive severe microcephaly. Autozygosity mapping and exome sequencing identified a homozygous novel single base pair deletion, c.1197delT in DMRTA2, predicted to result in a frameshift variant p.(Pro400Leufs*33). DMRTA2 encodes doublesex and mab-3-related transcription factor a2, a transcription factor key to the development of the dorsal telencephalon. Data from murine and zebrafish knockout models are consistent with the variant of DMTRA2 (DMRT5) as responsible for the cortical brain phenotype. Our study suggests that loss of function of DMRTA2 leads to a novel disorder of cortical development. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor.

PubMed

Huang, Julie; Roberts, Anthony J; Leschziner, Andres E; Reck-Peterson, Samara L

2012-08-31

The lissencephaly protein Lis1 has been reported to regulate the mechanical behavior of cytoplasmic dynein, the primary minus-end-directed microtubule motor. However, the regulatory mechanism remains poorly understood. Here, we address this issue using purified proteins from Saccharomyces cerevisiae and a combination of techniques, including single-molecule imaging and single-particle electron microscopy. We show that rather than binding to the main ATPase site within dynein's AAA+ ring or its microtubule-binding stalk directly, Lis1 engages the interface between these elements. Lis1 causes individual dynein motors to remain attached to microtubules for extended periods, even during cycles of ATP hydrolysis that would canonically induce detachment. Thus, Lis1 operates like a "clutch" that prevents dynein's ATPase domain from transmitting a detachment signal to its track-binding domain. We discuss how these findings provide a conserved mechanism for dynein functions in living cells that require prolonged microtubule attachments. Copyright © 2012 Elsevier Inc. All rights reserved.

Clinical-epidemiological description of live births with microcephaly in the state of Sergipe, Brazil, 2015.

PubMed

Cabral, Cibelle Mendes; Nóbrega, Martha Elizabeth Brasil da; Leite, Priscila Leal E; Souza, Mércia Simone Feitosa de; Teixeira, Daniela Cabral Pizzi; Cavalcante, Taíse Ferreira; Lima, Raulinna Gomes de Souza; Tavares, Lúcia Maria Sayde de Azevedo; Souza, Priscila Bochi de; Saad, Eduardo

2017-01-01

to describe the clinical and epidemiological characteristics of microcephaly cases in live births in Sergipe, Brazil, and to calculate the prevalence in its municipalities. this is a descriptive study on live births from September 1st to November 30th, 2015, with data from medical records and interviews with mothers. 83 cases of microcephaly were confirmed, with three deaths; prevalence in the 26 municipalities with confirmed cases ranged from 18 to 185/10,000 live births; the median of head circumference was 31 cm (range: 22.5-33.0); agenesis of corpus callosum (26/43), lissencephaly (12/43), absence of midline (10/43) and ventriculomegaly (8/43) were observed in the transfontanellar ultrasound; 40 mothers reported rash in pregnancy, 23 in the first trimester, with pruritus, arthralgia and headache; seven were positive for infections potentially causing malformations. there was a high occurrence of cases of microcephaly, and reports of signs and symptoms compatible with Zika virus infection during pregnancy.

Armadillo Repeat Containing 8α Binds to HRS and Promotes HRS Interaction with Ubiquitinated Proteins

PubMed Central

Tomaru, Koji; Ueda, Atsuhisa; Suzuki, Takeyuki; Kobayashi, Nobuaki; Yang, Jun; Yamamoto, Masaki; Takeno, Mitsuhiro; Kaneko, Takeshi; Ishigatsubo, Yoshiaki

2010-01-01

Recently, we reported that a complex with an essential role in the degradation of Fructose-1,6-bisphosphatase in yeast is well conserved in mammalian cells; we named this mammalian complex C-terminal to the Lissencephaly type-1-like homology (CTLH) complex. Although the function of the CTLH complex remains unclear, here we used yeast two-hybrid screening to isolate Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) as a protein binding to a key component of CTLH complex, Armadillo repeat containing 8 (ARMc8) α. The association was confirmed by a yeast two-hybrid assay and a co-immunoprecipitation assay. The proline-rich domain of HRS was essential for the association. As demonstrated through immunofluorescence microscopy, ARMc8α co-localized with HRS. ARMc8α promoted the interaction of HRS with various ubiquitinated proteins through the ubiquitin-interacting motif. These findings suggest that HRS mediates protein endosomal trafficking partly through its interaction with ARMc8α. PMID:20224683

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

PubMed Central

Huang, Julie; Roberts, Anthony J.; Leschziner, Andres E.; Reck-Peterson, Samara L.

2012-01-01

Summary The lissencephaly protein Lis1 has been reported to regulate the mechanical behavior of cytoplasmic dynein, the primary minus-end-directed microtubule motor. However, the regulatory mechanism remains poorly understood. Here, we address this issue using purified proteins from Saccharomyces cerevisiae and a combination of techniques, including single-molecule imaging and single-particle electron microscopy. We show that rather than binding to the main ATPase site within dynein's AAA+ ring or its microtubule-binding stalk directly, Lis1 engages the interface between these elements. Lis1 causes individual dynein motors to remain attached to microtubules for extended periods, even during cycles of ATP hydrolysis that would canonically induce detachment. Thus, Lis1 operates like a “clutch” that prevents dynein's ATPase domain from transmitting a detachment signal to its track-binding domain. We discuss how these findings provide a conserved mechanism for dynein functions in living cells that require prolonged microtubule attachments. PMID:22939623

Molecular genetics in fetal neurology.

PubMed

Huang, Jin; Wah, Isabella Y M; Pooh, Ritsuko K; Choy, Kwong Wai

2012-12-01

Brain malformations, particularly related to early brain development, are a clinically and genetically heterogeneous group of fetal neurological disorders. Fetal cerebral malformation, predominantly of impaired prosencephalic development namely agenesis of the corpus callosum and septo-optic dysplasia, is the main pathological feature in fetus, and causes prominent neurodevelopmental retardation, and associated with congenital facial anomalies and visual disorders. Differential diagnosis of brain malformations can be extremely difficult even through magnetic resonance imaging. Advances in genomic and molecular genetics technologies have led to the identification of the sonic hedgehog pathways and genes critical to the normal brain development. Molecular cytogenetic and genetic studies have identified numeric and structural chromosomal abnormalities as well as mutations in genes important for the etiology of fetal neurological disorders. In this review, we update the molecular genetics findings of three common fetal neurological abnormalities, holoprosencephaly, lissencephaly and agenesis of the corpus callosum, in an attempt to assist in perinatal and prenatal diagnosis. Copyright © 2012 Elsevier Ltd. All rights reserved.

Sonographic assessment of normal and abnormal patterns of fetal cerebral lamination.

PubMed

Pugash, D; Hendson, G; Dunham, C P; Dewar, K; Money, D M; Prayer, D

2012-12-01

Prenatal development of the brain is characterized by gestational age-specific changes in the laminar structure of the brain parenchyma before 30 gestational weeks. Cerebral lamination patterns of normal fetal brain development have been described histologically, by postmortem in-vitro magnetic resonance imaging (MRI) and by in-vivo fetal MRI. The purpose of this study was to evaluate the sonographic appearance of laminar organization of the cerebral wall in normal and abnormal brain development. This was a retrospective study of ultrasound findings in 92 normal fetuses and 68 fetuses with abnormal cerebral lamination patterns for gestational age, at 17-38 weeks' gestation. We investigated the visibility of the subplate zone relative to the intermediate zone and correlated characteristic sonographic findings of cerebral lamination with gestational age in order to evaluate transient structures. In the normal cohort, the subplate zone-intermediate zone interface was identified as early as 17 weeks, and in all 57 fetuses examined up to 28 weeks. In all of these fetuses, the subplate zone appeared anechoic and the intermediate zone appeared homogeneously more echogenic than did the subplate zone. In the 22 fetuses between 28 and 34 weeks, there was a transition period when lamination disappeared in a variable fashion. The subplate zone-intermediate zone interface was not identified in any fetus after 34 weeks (n=13). There were three patterns of abnormal cerebral lamination: (1) no normal laminar pattern before 28 weeks (n=32), in association with severe ventriculomegaly, diffuse ischemia, microcephaly, teratogen exposure or lissencephaly; (2) focal disruption of lamination before 28 weeks (n=24), associated with hemorrhage, porencephaly, stroke, migrational abnormalities, thanatophoric dysplasia, meningomyelocele or encephalocele; (3) increased prominence and echogenicity of the intermediate zone before 28 weeks and/or persistence of a laminar pattern beyond 33 weeks (n=10), associated with Type 1 lissencephaly or CMV infection. There was a mixed focal/diffuse pattern in two fetuses. In CMV infection, the earliest indication of the infection was focal heterogeneity and increased echogenicity of the intermediate zone, which predated the development of microcephaly, ventriculomegaly and intracranial calcification. The fetal subplate and intermediate zones can be demonstrated reliably on routine sonography before 28 weeks and disappear after 34 weeks. These findings represent normal gestational age-dependent transient laminar patterns of cerebral development and are consistent with histological studies. Abnormal fetal cerebral lamination patterns for gestational age are also visible on sonography, and may indicate abnormal brain development. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.

Geology and paleontology of five cores from Screven and Burke counties, eastern Georgia

USGS Publications Warehouse

Edwards, Lucy E.

2001-01-01

Five deep stratigraphic test holes were drilled from 1991 to 1993 in support of multidisciplinary investigations to determine the stratigraphy of Upper Cretaceous and Tertiary sediments of the coastal plain in east-central Georgia. Cored sediment and geological logs from the Millhaven test hole in Screven County and the Girard and Millers Pond test holes in Burke County are the primary sources of lithologic and paleontologic information from this report. Lithologic and paleontologic information from the Thompson Oak and McBean test holes in Burke County supplements the discussion of stratigraphy and sedimentation in the updip part of the study area near the Millers Pond test hole.

The diagnosis and treatment of infections of the pedal integument.

PubMed

Miller, S J

1986-07-01

Dr. Miller's discussion of the diagnosis and management of soft tissue infections is probably one of the most important topics in this issue. We are all faced with the potential for relatively minor infections becoming serious problems. Having a sound understanding of the infectious process and treatment regimens is extremely important in our general practices. Few things can make a patient as unhappy or destroy good surgical results as quickly and easily as an infection. I recommend reading the articles suggested by Dr. Miller and add that I believe that if the infection has not responded as quickly to therapy as is expected, an infectious disease consultation should be requested.

Project DEEP STEAM

NASA Astrophysics Data System (ADS)

Aeschliman, D. P.; Clay, R. G.; Donaldson, A. B.; Eisenhawer, S. W.; Fox, R. L.; Johnson, D. R.; Mulac, A. J.

1982-01-01

The objective of Project DEEP STEAM is to develop the technology to economically produce heavy oils from deep reservoirs. The tasks included in this project are the development of thermally efficient delivery systems and downhole steam generation systems. During the period January 1-March 31, 1981, effort has continued on a low pressure combustion downhole generator (Rocketdyne), and on two high pressure designs (Foster-Miller Associates, Sandia National Laboratories). The Sandia design was prepared for deployment in the Wilmington Field at Long Beach, California. Progress continued on the Min-Stress II packer concept at L'Garde, Inc., and on the extruded metal packer at Foster-Miller. Initial bare string field data are reported on the insulated tubular test at Lloydminster, Saskatchewan, Canada.

Two-Stage Mucogingival Surgery with Free Gingival Autograft and Biomend Membrane and Coronally Advanced Flap in Treatment of Class III Millers Recession

PubMed Central

Paul, Renny

2016-01-01

Introduction. Gingival recession is an apical shift of the gingival margin with exposure of the root surface. This migration of the marginal tissue leads to esthetic concerns, dentin hypersensitivity, root caries, and cervical wear. It is, paradoxically, a common finding in patients with a high standard of oral hygiene, as well as in periodontally untreated populations with poor oral hygiene. Changing the topography of the marginal soft tissue in order to facilitate plaque control is a common indication for root coverage procedures and forms a major aspect of periodontal plastic surgeries. The regeneration of a new connective tissue attachment to denuded root surface is by allowing the selective coronal regrowth of periodontal ligament cells while excluding the gingival tissues from the root during wound healing by means of a barrier membrane. Case Presentation. This case reports a two-stage surgical technique for treatment of Miller's class III defect using free gingival autograft and type I absorbable collagen membrane (BioMend®, Zimmer Dental, USA)§. Conclusions. The 6-month follow-up of the case showed a significant increase in attached gingiva suggesting it as a predictable alternative in the treatment of Millers class III defects. PMID:27525131

Investigation and Evaluation of Geopressured-Geothermal Wells; Detailed Reentry Prognosis for Geopressure-Geothermal Testing of the Watkins-Miller No.1 Well, Cameron Parish, Louisiana

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This prospect was drilled as the Superior Oil Company No. 1 Watkins-Miller, located in Section 5, T15S, R5W, Cameron Parish, Louisiana. The well site is just north of lot 39 on Indian Point Island and is readily accessible from State Highway 82 via a shell road which is in good condition. This location is shown on the lower portion of the USGS topographic sheet ''Grand Lake West''; a portion of this sheet is included. Superior Oil completed this well in late 1970 as a dual gas producer in sands between 11,150 and 11,250 feet and abandoned it in December 1974.more » This well was initially selected as the first Geo reentry candidate but was deferred when the landowner refused to grant reentry and test rights. He has, however, now indicated that he would be willing to grant those rights for a fee of $50,000. In view of the need for an alternate well to replace the State Lease 4183 No. 1, Gruy Federal has thoroughly reviewed alternate wells and concluded that the Watkins-Miller No. 1 requires minimal site preparation and is the reentry well of choice.« less

Simulations of Prebiotic Chemistry under Post-Impact Conditions on Titan.

PubMed

Turse, Carol; Leitner, Johannes; Firneis, Maria; Schulze-Makuch, Dirk

2013-12-17

The problem of how life began can be considered as a matter of basic chemistry. How did the molecules of life arise from non-biological chemistry? Stanley Miller's famous experiment in 1953, in which he produced amino acids under simulated early Earth conditions, was a huge leap forward in our understanding of this problem. Our research first simulated early Earth conditions based on Miller's experiment and we then repeated the experiment using Titan post-impact conditions. We simulated conditions that could have existed on Titan after an asteroid strike. Specifically, we simulated conditions after a potential strike in the subpolar regions of Titan that exhibit vast methane-ethane lakes. If the asteroid or comet was of sufficient size, it would also puncture the icy crust and bring up some of the subsurface liquid ammonia-water mixture. Since, O'Brian, Lorenz and Lunine showed that a liquid water-ammonia body could exist between about 102-104 years on Titan after an asteroid impact we modified our experimental conditions to include an ammonia-water mixture in the reaction medium. Here we report on the resulting amino acids found using the Titan post-impact conditions in a classical Miller experimental reaction set-up and how they differ from the simulated early Earth conditions.

Treatment of gingival recession with coronally advanced flap procedures: a systematic review.

PubMed

Cairo, Francesco; Pagliaro, Umberto; Nieri, Michele

2008-09-01

The treatment of buccal gingival recessions is a common requirement due to aesthetic concern or root sensitivity. The aim of this manuscript was to systematically review the literature on coronally advanced flap (CAF) alone or in combination with tissue grafts, barrier membranes (BM), enamel matrix derivative (EMD) or other material for treating gingival recession. Randomized clinical trials on treatment of Miller Class I and II gingival recessions with at least 6 months of follow-up were identified. Data sources included electronic databases and hand-searched journals. The primary outcome variable was complete root coverage (CRC). The secondary outcome variables were recession reduction, clinical attachment gain, keratinized tissue gain, aesthetic satisfaction, root sensitivity, post-operative patient pain and complications. A total of 794 Miller Class I and II gingival recessions in 530 patients from 25 RCTs were evaluated in this systematic review. CAF was associated with mean recession reduction and CRC. The addition of connective tissue graft (CTG) or EMD enhanced the clinical outcomes of CAF in terms of CRC, while BM did not. The results with respect to the adjunctive use of acellular dermal matrix were controversial. CTG or EMD in conjunction with CAF enhances the probability of obtaining CRC in Miller Class I and II single gingival recessions.

General anesthesia

MedlinePlus

... Miller's Anesthesia . 8th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 3. Hernandez A, Sherwood ER. Anesthesiology principles, pain management, and conscious sedation. In: Townsend CM Jr, Beauchamp ...

Clinical trial transparency: a reassessment of industry compliance with clinical trial registration and reporting requirements in the United States

PubMed Central

Lassman, Scott M; Shopshear, Olivia M; Jazic, Ina; Ulrich, Jocelyn; Francer, Jeffrey

2017-01-01

Objective To evaluate the accuracy of a 2015 cross-sectional analysis published in the BMJ Open which reported that pharmaceutical industry compliance with clinical trial registration and results reporting requirements under US law was suboptimal and varied widely among companies. Design We performed a reassessment of the data reported in Miller et al to evaluate whether statutory compliance analyses and conclusions were valid. Data sources Information from the Dryad Digital Repository, ClinicalTrials.gov, Drugs@FDA and direct communications with sponsors. Main outcome measures Compliance with the clinical trial registration and results reporting requirements under the Food and Drug Administration Amendments Act (FDAAA). Results Industry compliance with FDAAA disclosure requirements was notably higher than reported by Miller et al. Among trials subject to FDAAA, Miller et al reported that, per drug, a median of 67% (middle 50% range: 0%–100%) of trials fully complied with registration and results reporting requirements. On reanalysis of the data, we found that a median of 100% (middle 50% range: 93%–100%) of clinical trials for a particular drug fully complied with the law. When looking at overall compliance at the trial level, our reassessment yields 94% timely registration and 90% timely results reporting among the 49 eligible trials, and an overall FDAAA compliance rate of 86%. Conclusions The claim by Miller et al that industry compliance is below legal standards is based on an analysis that relies on an incomplete dataset and an interpretation of FDAAA that requires disclosure of study results for drugs that have not yet been approved for any indication. On reanalysis using a different interpretation of FDAAA that focuses on whether results were disclosed within 30 days of drug approval, we found that industry compliance with US statutory disclosure requirements for the 15 reviewed drugs was consistently high. PMID:28942418

Adapting water treatment design and operations to the impacts of global climate change

NASA Astrophysics Data System (ADS)

Clark, Robert M.; Li, Zhiwei; Buchberger, Steven G.

2011-12-01

It is anticipated that global climate change will adversely impact source water quality in many areas of the United States and will therefore, potentially, impact the design and operation of current and future water treatment systems. The USEPA has initiated an effort called the Water Resources Adaptation Program (WRAP) which is intended to develop tools and techniques that can assess the impact of global climate change on urban drinking water and wastewater infrastructure. A three step approach for assessing climate change impacts on water treatment operation and design is being persude in this effort. The first step is the stochastic characterization of source water quality, the second step is the application of the USEPA Water Treatment Plant model and the third step is the application of cost algorithms to provide a metric that can be used to assess the coat impact of climate change. A model has been validated using data collected from Cincinnati's Richard Miller Water Treatment Plant for the USEPA Information Collection Rule (ICR) database. An analysis of the water treatment processes in response to assumed perturbations in raw water quality identified TOC, pH, and bromide as the three most important parameters affecting performance of the Miller WTP. The Miller Plant was simulated using the EPA WTP model to examine the impact of these parameters on selected regulated water quality parameters. Uncertainty in influent water quality was analyzed to estimate the risk of violating drinking water maximum contaminant levels (MCLs).Water quality changes in the Ohio River were projected for 2050 using Monte Carlo simulation and the WTP model was used to evaluate the effects of water quality changes on design and operation. Results indicate that the existing Miller WTP might not meet Safe Drinking Water Act MCL requirements for certain extreme future conditions. However, it was found that the risk of MCL violations under future conditions could be controlled by enhancing existing WTP design and operation or by process retrofitting and modification.

Parametric Methods for Determining the Characteristics of Long-Term Metal Strength

NASA Astrophysics Data System (ADS)

Nikitin, V. I.; Rybnikov, A. I.

2018-06-01

A large number of parametric methods were proposed to calculate the characteristics of the long-term strength of metals. All of them are based on the fact that temperature and time are mutually compensating factors in the processes of metal degradation at high temperature under the action of a constant stress. The analysis of the well-known Larson-Miller, Dorn-Shcherby, Menson-Haferd, Graham-Wallace, and Trunin parametric equations is performed. The widely used Larson-Miller parameter was subjected to a detailed analysis. The application of this parameter to the calculation of ultimate long-term strength for steels and alloys is substantiated provided that the laws of exponential dependence on temperature and power dependence on strength for the heat resistance are observed. It is established that the coefficient C in the Larson- Miller equation is a characteristic of the heat resistance and is different for each material. Therefore, the use of a universal constant C = 20 in parametric calculations, as well as an a priori presetting of numerical C values for each individual group of materials, is unacceptable. It is shown in what manner it is possible to determine an exact value of coefficient C for any material of interest as well as to obtain coefficient C depending on stress in case such a dependence is manifested. At present, the calculation of long-term strength characteristics can be performed to a sufficient accuracy using Larson-Miller's parameter and its refinements described therein as well as on the condition that a linear law in logσ- P dependence is observed and calculations in the interpolation range is performed. The use of the presented recommendations makes it possible to obtain a linear parametric logσ- P dependence, which makes it possible to determine to a sufficient accuracy the values of ultimate long-term strength for different materials.

Ethical considerations of transparency, informed consent, and nudging in a patient with paediatric aortic stenosis and symptomatic left ventricular endocardial fibroelastosis.

PubMed

Mavroudis, Constantine D; Cook, Thomas; Jacobs, Jeffrey P; Mavroudis, Constantine

2016-12-01

A 9-year-old boy who was born with bicuspid aortic stenosis underwent two unsuccessful aortic valvuloplasty interventions, and by 2 years of age he developed restrictive cardiomyopathy caused by left ventricular endocardial fibroelastosis and diastolic dysfunction. The attending cardiologist referred the patient to a high-volume, high-profile congenital cardiac surgical programme 1000 miles away that has a team with considerable experience with left ventricular endocardial fibroelastosis resection and a reputation of achieving good results. Owing to problems with insurance coverage, the parents sought other options for the care of their child in their home state. Dr George Miller is a well-respected local congenital and paediatric cardiac surgeon with considerable experience with the Ross operation as well as with right ventricular endocardial fibroelastosis resection. When talking with Dr Miller, he implied that there is little difference between right ventricular endocardial fibroelastosis and left ventricular endocardial fibroelastosis resection, and stated that he would perform the operation with low mortality based on his overall experience. Dr Miller stated that the local institution could provide an equivalent surgical procedure with comparable outcomes, without the patient and family having to travel out of state. A fundamental dilemma that often arises in clinical surgical practice concerns the conduct of assessing and performing new procedures, especially in rare cases, for which the collective global experience is scant. Although Dr Miller has performed right ventricular endocardial fibroelastosis resection, this procedure differs from left ventricular endocardial fibroelastosis resection, and he cannot be sure that he will indeed be able to perform the procedure better than the high-volume surgeon. This ethical situation is best understood in terms of the principles of respect for patient autonomy, beneficence, non-maleficence, and justice. The tension between the imperatives of beneficence and the obligation to respect the autonomy of the patient by acting only with the patient's best interest in mind is discussed.

"Negative capacitance" in resistor-ferroelectric and ferroelectric-dielectric networks: Apparent or intrinsic?

NASA Astrophysics Data System (ADS)

Saha, Atanu K.; Datta, Suman; Gupta, Sumeet K.

2018-03-01

In this paper, we describe and analytically substantiate an alternate explanation for the negative capacitance (NC) effect in ferroelectrics (FE). We claim that the NC effect previously demonstrated in resistance-ferroelectric (R-FE) networks does not necessarily validate the existence of "S" shaped relation between polarization and voltage (according to Landau theory). In fact, the NC effect can be explained without invoking the "S"-shaped behavior of FE. We employ an analytical model for FE (Miller model) in which the steady state polarization strictly increases with the voltage across the FE and show that despite the inherent positive FE capacitance, reduction in FE voltage with the increase in its charge is possible in a R-FE network as well as in a ferroelectric-dielectric (FE-DE) stack. This can be attributed to a large increase in FE capacitance near the coercive voltage coupled with the polarization lag with respect to the electric field. Under certain conditions, these two factors yield transient NC effect. We analytically derive conditions for NC effect in R-FE and FE-DE networks. We couple our analysis with extensive simulations to explain the evolution of NC effect. We also compare the trends predicted by the aforementioned Miller model with Landau-Khalatnikov (L-K) model (static negative capacitance due to "S"-shape behaviour) and highlight the differences between the two approaches. First, with an increase in external resistance in the R-FE network, NC effect shows a non-monotonic behavior according to Miller model but increases according to L-K model. Second, with the increase in ramp-rate of applied voltage in the FE-DE stack, NC effect increases according to Miller model but decreases according to L-K model. These results unveil a possible way to experimentally validate the actual reason of NC effect in FE.

Submicron particle monitoring of paving and related road construction operations.

PubMed

Freund, Alice; Zuckerman, Norman; Baum, Lisa; Milek, Debra

2012-01-01

This study identified activities and sources that contribute to ultrafine and other submicron particle exposure that could trigger respiratory symptoms in highway repair workers. Submicron particle monitoring was conducted for paving, milling, and pothole repair operations in a major metropolitan area where several highway repair workers were identified as symptomatic for respiratory illness following exposures at the 2001 World Trade Center disaster site. Exposure assessments were conducted for eight trades involved in road construction using a TSI P-Trak portable condensation particle counter. Direct readings near the workers' breathing zones and observations of activities and potential sources were logged on 7 days on 27 workers using four different models of pavers and two types of millers. Average worker exposure levels ranged from 2 to 3 times background during paving and from 1 to 4 times background during milling. During asphalt paving, average personal exposures to submicron particulates were 25,000-60,000, 28,000-70,000, and 23,000-37,000 particles/ cm(3) for paver operators, screed operators, and rakers, respectively. Average personal exposures during milling were 19,000-111,000, 28,000-81,000, and 19,000 particles/cm(3) for the large miller operators, miller screed operators, and raker, respectively. Personal peak exposures were measured up to 467,000 and 455,000 particles/cm(3) in paving and milling, respectively. Several sources of submicron particles were identified. These included the diesel and electric fired screed heaters; engine exhaust from diesel powered construction vehicles passing by or idling; raking, dumping, and paving of asphalt; exhaust from the hotbox heater; pavement dust or fumes from milling operations, especially when the large miller started and stopped; and secondhand cigarette smoke. To reduce the potential for health effects in workers, over 40 recommendations were made to control exposures, including improved maintenance of paver ventilation systems; diesel fume engineering controls; reduced idling; provision of cabs for the operators; and improved dust suppression systems on the milling machine.

Simulation of organic molecule formation in solar system environments-The Miller-Urey Experiment in Space project overview

NASA Astrophysics Data System (ADS)

Kotler, J. Michelle; Ehrenfruend, Pascale; Botta, Oliver; Blum, Jurgen; Schrapler, Rainer; van Dongen, Joost; Palmans, Anja; Sephton, Mark A.; Martins, Zita; Cleaves, Henderson J.; Ricco, Antonio

The Miller-Urey Experiment in space (MUE) investigates the formation of potential prebiotic organic compounds in the early solar system environment. The MUE experiment will be sent to and retrieved from the International Space Station (ISS), where it will be performed inside the Microgravity Science Glovebox (MSG). The goal of this space experiment is to understand prebiotic reactions in microgravity by simulating environments of the early solar nebula. The dynamic environment of the solar nebula with the simultaneous presence of gas, particles, and energetic processes, including shock waves, lightning, and radiation may trigger a rich organic chemistry leading to organic molecules. These environments will be simulated in six fabricated vials containing various gas mixtures as well as solid particles. Two gas mixture compositions will be tested and subjected to continuous spark discharges for 48, 96, and 192 hours. Silicate particles will serve as surfaces on which thin water ice mantles can accrete. The particles will move repeatedly through a high-voltage spark discharge in microgravity, enabling chemical re-actions analogous to the original Miller-Urey experiment. The experiment will be performed at low temperatures (-5 C), slowing hydrolysis and improving chances of detection of interme-diates, initial products, and their distributions. Executing the Miller-Urey experiment in the space environment (microgravity) allows us to simulate conditions that could have prevailed in the energetic early solar nebula and provides insights into the chemical pathways that may occur in forming planetary systems. Analysis will be performed post-flight using chemical analytical methods. The anticipated results will provide information about chemical reaction pathways to form organic compounds in space environment, emphasizing abiotic chemical pathways and mechanisms that could have been crucial in the formation of biologically relevant compounds such as amino acids and nucleobases, basic constituents common to life on Earth.

Abnormal predicted diffusion capacities in healthy Asians: an inequality with a solution.

PubMed

Pesola, Gene R; Huggins, Gladstone; Sherpa, Tsering Y

2006-01-01

Asian lung volumes are 10-15% less than those of Caucasians. To test the hypothesis that healthy Asians might be labeled as abnormal using three commonly used Caucasian-derived prediction equation estimates (PEE) of DLCO currently used. In addition, a Chinese-derived PEE of DLCO was tested to determine its validity in non-Chinese Asians. Forty-one healthy Asians underwent DLCO testing. Controls consisted of the PEE and 12 healthy Caucasians. Measured DLCO was compared with the Miller, Knudson, Crapo and one Chinese PEE. Abnormal was defined as a DLCO <80% predicted. Gas dilution and plethysmography estimated alveolar volume. Proportions in parentheses in the results below are DLCO adjusted for alveolar volume. The average Asian DLCO was 25.75 +/- 5.55 ml/min/mm Hg, no different than the predicted DLCO of 25.29 +/- 5.53 seen with Chinese PEE. This was different (p < 0.01) than the predicted DLCO of 27.82 +/- 5.09, 33.66 +/- 6.29, and 31.64 +/- 5.33 for the Miller, Knudson, and Crapo equations, respectively. This resulted in 4/41 (0/41), 27/39 (2/39), 21/41 (3/41) and 1/41 (0/41) DLCO measurements being defined as abnormal using Miller, Knudson, Crapo and Chinese PEE, respectively. In Caucasians, the measured DLCO was similar to the Miller but significantly lower than the Knudson and Crapo PEE. Measured lung volumes were significantly smaller compared to predicted for the three Caucasian PEE in Asians, with no difference in Caucasians. There was no difference in measured lung volumes and Chinese PEE. Current Caucasian PEE for DLCO when used in healthy Asians result in an abnormal reading that is incorrect from 10 to 50% of the time. This PEE failure is related to a reduction in lung volume not accounted for. The Chinese PEE for DLCO works for non-Chinese Asians and should replace Caucasian PEE in the US in all Asians.

Physical stratigraphy and hydrostratigraphy of Upper Cretaceous and Paleocene sediments, Burke and Screven Counties, Georgia

USGS Publications Warehouse

Falls, W.F.; Baum, J.S.; Prowell, D.C.

1997-01-01

Six geologic units are recognized in the Cretaceous and the Paleocene sediments of eastern Burke and Screven Counties in Georgia on the basis of lithologic, geophysical, and paleontologic data collected from three continuously cored testholes in Georgia and one testhole in South Carolina. The six geologic units are separated by regional unconformities and are designated from oldest to youngest as the Cape Fear Formation, the Middendorf Formation, the Black Creek Group (undivided), and the Steel Creek Formation in the Upper Cretaceous section, and the Ellenton and the Snapp Formations in the Paleocene section. The geologic units provide a spatial and temporal framework for the identification and correlation of a basal confining unit beneath the Midville aquifer system and five aquifers and five confining units in the Dublin and the Midville aquifer systems. The Dublin aquifer system is divided hydrostratigraphically into the Millers Pond, the upper Dublin, and the lower Dublin aquifers. The Midville aquifer system is divided hydrostratigraphically into the upper and the lower Midville aquifers. The fine-grained sediments of the Millers Pond, the lower Dublin, and the lower Midville confining units are nonmarine deposits and are present in the upper part of the Snapp Formation, the Black Creek Group (undivided), and the Middendorf Formation, respectively. Hydrologic data for specific sets of monitoring wells at the Savannah River Site in South Carolina and the Millers Pond site in Georgia confirm that these three units are leaky confining units and locally impede vertical ground-water flow between adjacent aquifers. The fine-grained sediments of the upper Dublin and the upper Midville confining units are marine-deltaic deposits of the Ellenton Formation and the Black Creek Group (undivided), respectively. Hydrologic data confirm that the upper Dublin confining unit regionally impedes vertical ground-water flow on both sides of the Savannah River. The upper Midville confining unit impedes vertical ground-water flow in the middle and downdip parts of the study area and is a leaky confining unit in the updip part of the study area. Recognition of the upper Dublin confining unit as a regional confining unit between the Millers Pond and the upper Dublin aquifers also confirms that the Millers Pond aquifer is a separate hydrologic unit from the rest of the Dublin aquifer system. This multi-aquifer framework increases the vertical hydrostratigraphic resolution of hydraulic properties and gradients in the Dublin and Midville aquifer systems for the investigation of ground-water flow beneath the Savannah River in the vicinity of the U.S. Department of Energy Savannah River Site.

Treatment of multiple adjacent Miller class I and II gingival recessions with a Modified Coronally Advanced Tunnel (MCAT) technique and a collagen matrix or palatal connective tissue graft: a randomized, controlled clinical trial.

PubMed

Aroca, Sofia; Molnár, Bálint; Windisch, Péter; Gera, István; Salvi, Giovanni E; Nikolidakis, Dimitris; Sculean, Anton

2013-07-01

A newly developed collagen matrix (CM) of porcine origin has been shown to represent a potential alternative to palatal connective tissue grafts (CTG) for the treatment of single Miller Class I and II gingival recessions when used in conjunction with a coronally advanced flap (CAF). However, at present it remains unknown to what extent CM may represent a valuable alternative to CTG in the treatment of Miller Class I and II multiple adjacent gingival recessions (MAGR). The aim of this study was to compare the clinical outcomes following treatment of Miller Class I and II MAGR using the modified coronally advanced tunnel technique (MCAT) in conjunction with either CM or CTG. Twenty-two patients with a total of 156 Miller Class I and II gingival recessions were included in this study. Recessions were randomly treated according to a split-mouth design by means of MCAT + CM (test) or MCAT + CTG (control). The following measurements were recorded at baseline (i.e. prior to surgery) and at 12 months: Gingival Recession Depth (GRD), Probing Pocket Depth (PD), Clinical Attachment Level (CAL), Keratinized Tissue Width (KTW), Gingival Recession Width (GRW) and Gingival Thickness (GT). GT was measured 3-mm apical to the gingival margin. Patient acceptance was recorded using a Visual Analogue Scale (VAS). The primary outcome variable was Complete Root Coverage (CRC), secondary outcomes were Mean Root Coverage (MRC), change in KTW, GT, patient acceptance and duration of surgery. Healing was uneventful in both groups. No adverse reactions at any of the sites were observed. At 12 months, both treatments resulted in statistically significant improvements of CRC, MRC, KTW and GT compared with baseline (p < 0.05). CRC was found at 42% of test sites and at 85% of control sites respectively (p < 0.05). MRC measured 71 ± 21% mm at test sites versus 90 ± 18% mm at control sites (p < 0.05). Mean KTW measured 2.4 ± 0.7 mm at test sites versus 2.7 ± 0.8 mm at control sites (p > 0.05). At test sites, GT values changed from 0.8 ± 0.2 to 1.0 ± 0.3 mm, and at control sites from 0.8 ± 0.3 to 1.3 ± 0.4 mm (p < 0.05). Duration of surgery and patient morbidity was statistically significantly lower in the test compared with the control group respectively (p < 0.05). The present findings indicate that the use of CM may represent an alternative to CTG by reducing surgical time and patient morbidity, but yielded lower CRC than CTG in the treatment of Miller Class I and II MAGR when used in conjunction with MCAT. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Pick disease

MedlinePlus

... Frontotemporal dementia; FTD; Arnold Pick disease; 3R tauopathy Images Central nervous system and peripheral nervous system References Bang J, Spina S, Miller BL. Frontotemporal dementia. Lancet . 2015;386( ...

Spinal and epidural anesthesia

MedlinePlus

... Miller's Anesthesia . 8th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 56. Hernandez A, Sherwood ER. Anesthesiology principles, pain management, and conscious sedation. In: Townsend CM Jr, Beauchamp ...

Where's Waldo? The 'decapitation gambit' and the definition of death.

PubMed

Lizza, John P

2011-12-01

The 'decapitation gambit' holds that, if physical decapitation normally entails the death of the human being, then physiological decapitation, evident in cases of total brain failure, entails the death of the human being. This argument has been challenged by Franklin Miller and Robert Truog, who argue that physical decapitation does not necessarily entail the death of human beings and that therefore, by analogy, artificially sustained human bodies with total brain failure are living human beings. They thus challenge the current neurological criterion for determining death and argue for a return to the traditional criterion of the irreversible loss of circulation and respiration. In this paper, I defend the decapitation gambit and total brain failure as a criterion for determining death against Miller and Truog's criticism.

A survey for potential biological control agents of Pereskia aculeata Miller (Cactaceae) in Brazil reveals two new species of Horismenus Walker (Hymenoptera: Eulophidae).

PubMed

Pikart, Tiago G; Costa, Valmir A; Hansson, Christer; Cristo, Sandra C DE; Vitorino, Marcelo D

2017-05-30

This paper deals with the description of two new species of Horismenus Walker (Hymenoptera: Eulophidae) from Brazil, parasitoids of larvae of Adetus analis (Haldeman) (Coleoptera: Cerambycidae). Both species are similar to Horismenus steirastomae (Girault), a species that also parasitizes cerambycids. Adetus analis is a pest of Sechium edule (Jacq.) Swartz (Cucurbitaceae), a minor crop in Brazil, Argentina and U.S.A., but also feeds in stems of Pereskia aculeata Miller (Cactaceae), an ornamental plant that has become a problematic weed species in Africa, where it was introduced. The two new Horismenus species are described, diagnosed, and compared to H. steirastomae.

Acetylcholine causes rooting in leaf explants of in vitro raised tomato (Lycopersicon esculentum Miller) seedlings.

PubMed

Bamel, Kiran; Gupta, Shrish Chandra; Gupta, Rajendra

2007-05-30

The animal neurotransmitter acetylcholine (ACh) induces rooting and promotes secondary root formation in leaf explants of tomato (Lycopersicon esculentum Miller var. Pusa Ruby), cultured in vitro on Murashige and Skoog's medium. The roots originate from the midrib of leaf explants and resemble taproot. ACh at 10(-5) M was found to be the optimum over a wide range of effective concentrations between 10(-7) and 10(-3) M. The breakdown products, choline and acetate were ineffective even at 10(-3) M concentration. ACh appears to have a natural role in tomato rhizogenesis because exogenous application of neostigmine, an inhibitor of ACh hydrolysis, could mimic the effect of ACh. Neostigmine, if applied in combination with ACh, potentiated the ACh effect.

Functionalizing Ultra-Low Energy Nonlinear Optics: Analysis and Suppression of Quantum Fluctuations

DTIC Science & Technology

2010-01-24

34 Phys. Rev. A 80, 045802 (2009). M. A. Armen , A. E. Miller and H. Mabuchi, "Spontaneous Dressed-State Polarization in the Strong Driving Regime of...H. Mabuchi, “Derivation of Maxwell‐Bloch‐type equations by projection of quantum models,” Phys.  Rev. A 78, 015801, (2008).  [4]  M.  Armen  and H...models of switches for attojoule‐scale nanophotonic logic,” Phys. Rev. A 80,  045802 (2009).  [7] M. A.  Armen , A. E. Miller and H. Mabuchi, “Spontaneous

Nutrition and athletic performance

MedlinePlus

Exercise - nutrition; Exercise - fluids; Exercise - hydration ... Bird R. Nutrition. In: Miller MD, Thompson SR, eds. DeLee and Drez's Orthopaedic Sports Medicine . 4th ed. Philadelphia, PA: Elsevier Saunders; ...

Ignoring the data and endangering children: why the mature minor standard for medical decision making must be abandoned.

PubMed

Cherry, Mark J

2013-06-01

In Roper v. Simmons (2005) the United States Supreme Court announced a paradigm shift in jurisprudence. Drawing specifically on mounting scientific evidence that adolescents are qualitatively different from adults in their decision-making capacities, the Supreme Court recognized that adolescents are not adults in all but age. The Court concluded that the overwhelming weight of the psychological and neurophysiological data regarding brain maturation supports the conclusion that adolescents are qualitatively different types of agents than adult persons. The Supreme Court further solidified its position regarding adolescents as less than fully mature and responsible decisionmakers in Graham v. Florida (2010) and Miller v. Alabama (2012). In each case, the Court concluded that the scientific evidence does not support the conclusion that children under 18 years of age possess adult capacities for personal agency, rationality, and mature choice. This study explores the implications of the Supreme Court decisions in Roper v. Simmons, Graham v. Florida, and Miller v. Alabama for the "mature minor" standard for medical decision making. It argues that the Supreme Court's holdings in Roper, Graham, and Miller require no less than a radical reassessment of how healthcare institutions, courts of law, and public policy are obliged to regard minors as medical decisionmakers. The "mature minor" standard for medical decision making must be abandoned.

Recording of Supernovae in Rock Art, A Case Study at the Paint Rock Pictograph Site

NASA Astrophysics Data System (ADS)

Houston, Gordon L.; Simonia, Irakli; NA

2017-01-01

The Paint Rock pictographs in central Texas and their use as solar markers were formally reported for the first time by Dr. R. Robert Robbins at the 1999 AAS meeting #193 in Austin, Texas. He reported the operations of the winter solstice marker and suggested the possibility of more, including a summer solstice solar marker. Since this first report, there have been many informal studies of the Paint Rock site. In 1955, William C. Miller made the first interpretation of rock art as depicting images of the Crab supernova of AD 1054, which has produced many reports at other rock art sites in the American Southwest, including one at Paint Rock. All of these claims have a star and crescent configuration. Recently, these claims have been dismissed. We propose that the second panel at Paint Rock is representative of Tycho Brahe's supernovae SN1572. Miller set up a set of restrictions and criteria to evaluate these potential claims. We discuss Miller's criteria and two additional sets of criteria to evaluate representations of historical records of supernovae sightings. Two sets of characteristics of supernovae are provided, the first being galactic location and the second observational characteristics of naked eye supernovae. Employing astronomical software, we show that the panel at Paint Rock meets the restrictions and criteria discussed, that leads to high confidence in stating it records Tycho Brahe's supernova SN1572.

capr-contact us | Center for Cancer Research

Cancer.gov

CAPR Contacts: Dr. Shyam Sharan, Director; Dr. Zoe Weaver Ohler, Preclinical Team Leader; Dr. Serguei Kozlov, Technology Optimization Team Leader; Ken Miller, Project Manager; Chris Hester, Administrative Assistant

Vasectomy

MedlinePlus

... a man's ability to have an erection or orgasm, or to ejaculate semen. A vasectomy does NOT ... Miller, MD, urologist in private practice in Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla ...

Concussion - adults - discharge

MedlinePlus

Brain injury - concussion - discharge; Traumatic brain injury - concussion - discharge; Closed head injury - concussion - discharge ... Barth JT, Broshek DK, Freeman JR. Concussion and brain injury. In: Miller MD, Thompson SR, eds. DeLee ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yaghi, Omar

Jeff Miller, head of Public Affairs, sat down in conversation with Omar Yaghi, director of the Molecular Foundry, in the first of a series of "powerpoint-free" talks on July 11th 2012, at Berkeley Lab.

Comparing Feedback Methods after Testing

ERIC Educational Resources Information Center

Forster, Jerald R.

1969-01-01

Based on the author's doctoral dissertation, University of Minnesota. Requestions for reprints should be sent to: Jerald Forster, Department of Educational Psychology, 318 Miller Hall, Univ. of Wash., Seattle, Washington 98105.

Smashed fingers

MedlinePlus

... Crushed digits Images Smashed fingers References Brunton LM, Graham TJ, Atkinson RE. Hand injuries. In: Miller MD, ... Review Date 4/18/2017 Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports Medicine and Shoulder ...

Satellite instrument provides nighttime sensing capability

NASA Astrophysics Data System (ADS)

Showstack, Randy

2012-12-01

"This is not your father's low-light sensor," Steve Miller, senior research scientist and deputy director of the Cooperative Institute for Research in the Atmosphere at Colorado State University, Fort Collins, said at a 5 December news briefing at the AGU Fall Meeting. He and others at the briefing were showing off the nighttime sensing capability of the day/night band of the Visible Infrared Imaging Radiometer Suite (VIIRS) of instruments onboard the Suomi National Polar-orbiting Partnership (NPP) Earth-observing research satellite, a joint NASA and National Oceanic and Atmospheric Administration (NOAA) satellite that was launched on 28 October 2011. Noting that low-light satellite technology has been available for about 40 years, Miller said that the VIIRS day/night band "is truly a paradigm shift in the technology and capability."

Miller, Mulberry, Brewer, and Evered nominations. Hearing before Committee on Energy and Natural Resources, United States Senate, Ninety-Seventh Congress

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-01-01

Four presidential nominees were questioned by members of the committee and by 11 witnesses, who also made statements pertinent to the nomination: Daniel N. Miller, Jr., to be Ass't. Secy. of Interior for Energy and Minerals; Richard Mulberry, to be Inspector General, Dept. of Interior; Shelby T. Brewer to be Ass't. Secy. for Nuclear Energy; and J. Erich Evered, to be Administrator of the Energy Information Administration, Department of Energy. The statements and responses are followed by additional material submitted for the record and informational statements and responses of the nominees. The nominees were questioned about past activities and theirmore » policy goals as well as their plans for conducting their respective offices. (DCK)« less

Operations Manager Tim Miller checks out software for the Airborne Synthetic Aperature Radar (AIRSAR

NASA Technical Reports Server (NTRS)

1998-01-01

Tim Miller checks out software for the Airborne Synthetic Aperture Radar (AIRSAR). He was the AIRSAR operations manager for NASA's Jet Propulsion Laboratory. The AIRSAR produces imaging data for a range of studies conducted by the DC-8. NASA is using a DC-8 aircraft as a flying science laboratory. The platform aircraft, based at NASA's Dryden Flight Research Center, Edwards, Calif., collects data for many experiments in support of scientific projects serving the world scientific community. Included in this community are NASA, federal, state, academic and foreign investigators. Data gathered by the DC-8 at flight altitude and by remote sensing have been used for scientific studies in archeology, ecology, geography, hydrology, meteorology, oceanography, volcanology, atmospheric chemistry, soil science and biology.

78 FR 9067 - Receipt of Applications for Endangered Species Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-07

... County, Alabama. Permit Application Number: TE-91366A Applicant: Dr. Paul Stewart, Troy, Alabama...: TE-91373A Applicant: Jonathan Miller, Troy, Alabama. Applicant requests authorization to take...

Bone pain or tenderness

MedlinePlus

McCormack RG, Lopez CA. Commonly encountered fractures in sports medicine. In: Miller MD, Thompson SR, eds. DeLee and Drez's Orthopaedic Sports Medicine . 4th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap ...

Rheumatoid Arthritis: Can It Affect the Eyes?

MedlinePlus

Rheumatoid arthritis: Can it affect the eyes? Can rheumatoid arthritis affect the eyes? Answers from April Chang-Miller, M.D. Rheumatoid arthritis is a chronic inflammatory disease that primarily affects ...

Dear Hillary....

PubMed

Pherwani, M; Hostetler, C; Miller, S

1993-10-01

As Hillary Clinton worked on the reforms of the US health system, three University of Minnesota fellows, Meeta Pherwani, Craig Hostetler and Sarah Miller, offered her some advice based on their experience with the NHS.

77 FR 54608 - Southeast Oregon Resource Advisory Council (RAC); Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-05

... wildfires, subsequent stabilization and rehabilitation efforts, effected resources and the status of...; and a partial-day field tour to the Miller Homestead wildfire area near Frenchglen, Oregon. The...

Josh Miller HEARTS Act

THOMAS, 111th Congress

Sen. Voinovich, George V. [R-OH

2009-06-08

Senate - 06/08/2009 Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Rheumatoid Arthritis: Can It Affect the Lungs?

MedlinePlus

Rheumatoid arthritis: Can it affect the lungs? Can rheumatoid arthritis affect your lungs? Answers from April Chang-Miller, M.D. Although rheumatoid arthritis primarily affects joints, it sometimes causes lung disease ...

Josh Miller HEARTS Act

THOMAS, 112th Congress

Sen. Brown, Sherrod [D-OH

2012-02-14

Senate - 02/14/2012 Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Fractional Zinc Absorption for Men, Women, and Adolescents Is Overestimated in the Current Dietary Reference Intakes.

PubMed

Armah, Seth M

2016-06-01

The fractional zinc absorption values used in the current Dietary Reference Intakes (DRIs) for zinc were based on data from published studies. However, the inhibitory effect of phytate was underestimated because of the low phytate content of the diets in the studies used. The objective of this study was to estimate the fractional absorption of dietary zinc from the US diet by using 2 published algorithms. Nutrient intake data were obtained from the NHANES 2009-2010 and the corresponding Food Patterns Equivalents Database. Data were analyzed with the use of R software by taking into account the complex survey design. The International Zinc Nutrition Consultative Group (IZiNCG; Brown et al. Food Nutr Bull 2004;25:S99-203) and Miller et al. (Br J Nutr 2013;109:695-700) models were used to estimate zinc absorption. Geometric means (95% CIs) of zinc absorption for all subjects were 30.1% (29.9%, 30.2%) or 31.3% (30.9%, 31.6%) with the use of the IZiNCG model and Miller et al. model, respectively. For men, women, and adolescents, absorption values obtained in this study with the use of the 2 models were 27.2%, 31.4%, and 30.1%, respectively, for the IZiNCG model and 28.0%, 33.0%, and 31.6%, respectively, for the Miller et al. model, compared with the 41%, 48%, and 40%, respectively, used in the current DRIs. For preadolescents, estimated absorption values (31.1% and 32.8% for the IZiNCG model and Miller et al. model, respectively) compare well with the conservative estimate of 30% used in the DRIs. When the new estimates of zinc absorption were applied to the current DRI values for men and women, the results suggest that the Estimated Average Requirement (EAR) and RDA for these groups need to be increased by nearly one-half of the current values in order to meet their requirements for absorbed zinc. These data suggest that zinc absorption is overestimated for men, women, and adolescents in the current DRI. Upward adjustments of the DRI for these groups are recommended. © 2016 American Society for Nutrition.

Effects of starvation on the transport of Escherichia coli K12 in saturated porous media are dependent on pH and ionic strength

NASA Astrophysics Data System (ADS)

Xu, S.; Walczak, J. J.; Wang, L.; Bardy, S. L.; Li, J.

2010-12-01

In this research, we investigate the effects of starvation on the transport of E. coli K12 in saturated porous media. Particularly, we examine the relationship between such effects and the pH and ionic strength of the electrolyte solutions that were used to suspend bacterial cells. E. coli K12 (ATCC 10798) cells were cultured using either Luria-Bertani Miller (LB-Miller) broth (10 g trypton, 5 g yeast extract and 10 g NaCl in 1 L of deionized water) or LB-Luria broth (10 g tryptone, 5 g yeast extract and 0.5 g NaCl in 1 L of deionized water). Both broths had similar pH (~7.1) but differed in ionic strength (LB-Miller: ~170 mM, LB-Luria: ~ 8 mM). The bacterial cells were then harvested and suspended using one of the following electrolyte solutions: phosphate buffered saline (PBS) (pH ~7.2; ionic strength ~170 mM), 168 mM NaCl (pH ~5.7), 5% of PBS (pH ~ 7.2; ionic strength ~ 8 mM) and 8 mM NaCl (pH ~ 5.7). Column transport experiments were performed at 0, 21 and 48 hours following cell harvesting to evaluate the change in cell mobility over time under “starvation” conditions. Our results showed that 1) starvation increased the mobility of E. coli K12 cells; 2) the most significant change in mobility occurred when bacterial cells were suspended in an electrolyte solution that had different pH and ionic strength (i.e., LB-Miller culture suspended in 8 mM NaCl and LB-Luria culture suspended in 168 mM Nacl); and 3) the change in cell mobility primarily occurred within the first 21 hours. The size of the bacterial cells was measured and the surface properties (e.g., zeta potential, hydrophobicity, cell-bound protein, LPS sugar content, outer membrane protein profiles) of the bacterial cells were characterized. We found that the measured cell surface properties could not fully explain the observed changes in cell mobility caused by starvation.

28 CFR 79.53 - Proof of employment as a miller.

Code of Federal Regulations, 2014 CFR

2014-07-01

... its successor-in-interest; (3) Records of the Social Security Administration reflecting the identity... claimant's employer and occupation; (7) Records of an academic or scholarly study, not conducted in...

28 CFR 79.53 - Proof of employment as a miller.

Code of Federal Regulations, 2011 CFR

2011-07-01

... its successor-in-interest; (3) Records of the Social Security Administration reflecting the identity... claimant's employer and occupation; (7) Records of an academic or scholarly study, not conducted in...

28 CFR 79.53 - Proof of employment as a miller.

Code of Federal Regulations, 2013 CFR

2013-07-01

... its successor-in-interest; (3) Records of the Social Security Administration reflecting the identity... claimant's employer and occupation; (7) Records of an academic or scholarly study, not conducted in...

28 CFR 79.53 - Proof of employment as a miller.

Code of Federal Regulations, 2012 CFR

2012-07-01

... its successor-in-interest; (3) Records of the Social Security Administration reflecting the identity... claimant's employer and occupation; (7) Records of an academic or scholarly study, not conducted in...

Annual Quality Assurance Conference Presentations by Glynda Smith and Carrie Miller

EPA Pesticide Factsheets

25th Annual Quality Assurance Conference Presentation: Disinfectants/Disinfection Byproducts –Rules and Requirements and Presentation: Long Term 2 Enhanced Surface Water Treatment Rule (LT2) Cryptosporidium Monitoring

Cancer Data and Statistics Tools

MedlinePlus

... Joseph Jacqueline W. Miller Mona Saraiya Judith Lee Smith Sherri L. Stewart Mary C. White Debra Younginer ... MD, MPH Simple Singh, MD, MPH Judith Lee Smith, PhD Sherri L. Stewart, PhD Eric Tai, MD, ...

28 CFR 79.52 - Criteria for eligibility for claims by uranium millers.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., 1942, and ending on December 31, 1971; and (c) The claimant contracted primary lung cancer, a nonmalignant respiratory disease, primary renal cancer, or chronic renal disease (including nephritis and...

78 FR 23598 - National Space-Based Positioning, Navigation, and Timing (PNT) Advisory Board; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

...: Mr. James J. Miller, Human Exploration and Operations Mission Directorate, NASA Headquarters... potential PNT service degradation if adjacent radio-band spectrum interference is introduced. Patricia D...

75 FR 10841 - Sunshine Act; Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-09

... Meeting of the Federal Energy Regulatory Commission and the Nuclear Regulatory Commission on Grid Reliability (Public Meeting). (Contact: Kenn Miller, 301-415-3152.) This meeting will be webcast live at the....) [[Page 10842

4. Historic American Buildings Survey Alex Bush, Photographer, March 25, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey Alex Bush, Photographer, March 25, 1937 SMOKE HOUSE. WEST (FRONT) AND NORTH SIDE - Sellers-Henderson House & Smokehouse, State Route 28, Millers Ferry, Wilcox County, AL

28 CFR 79.52 - Criteria for eligibility for claims by uranium millers.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., 1942, and ending on December 31, 1971; and (c) The claimant contracted primary lung cancer, a nonmalignant respiratory disease, primary renal cancer, or chronic renal disease (including nephritis and...

Cody Miller Initiative for Safer Prescriptions Act

THOMAS, 113th Congress

Sen. Gillibrand, Kirsten E. [D-NY

2013-04-17

Senate - 04/17/2013 Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Cody Miller Initiative for Safer Prescriptions Act

THOMAS, 112th Congress

Sen. Gillibrand, Kirsten E. [D-NY

2012-05-22

Senate - 05/22/2012 Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

5. Foreground: ore bridges, ore/coke/limestone bins, Detroit River; background: stock ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Foreground: ore bridges, ore/coke/limestone bins, Detroit River; background: stock house on left, stripper building, BOF. Looking south/southwest - Rouge Steel Company, 3001 Miller Road, Dearborn, MI

28 CFR 79.52 - Criteria for eligibility for claims by uranium millers.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., 1942, and ending on December 31, 1971; and (c) The claimant contracted primary lung cancer, a nonmalignant respiratory disease, primary renal cancer, or chronic renal disease (including nephritis and...

28 CFR 79.52 - Criteria for eligibility for claims by uranium millers.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., 1942, and ending on December 31, 1971; and (c) The claimant contracted primary lung cancer, a nonmalignant respiratory disease, primary renal cancer, or chronic renal disease (including nephritis and...

28 CFR 79.52 - Criteria for eligibility for claims by uranium millers.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., 1942, and ending on December 31, 1971; and (c) The claimant contracted primary lung cancer, a nonmalignant respiratory disease, primary renal cancer, or chronic renal disease (including nephritis and...

5. American elevator looking east barely visible behind American malt ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. American elevator looking east barely visible behind American malt house with Russell-Miller flour mill to right (now Eonacara and idle). - American Elevator, 87 Childs Street, Buffalo, Erie County, NY

Results of interlaboratory comparison of fission track ages for 1992 fission track workshop

USGS Publications Warehouse

Miller, D.S.; Crowley, K.D.; Dokka, R.K.; Galbraith, R.F.; Kowallis, B.J.; Naeser, C.W.

1993-01-01

Two apatites and one sphene were made available to the fission track research community for analysis prior to the 1992 Fission Track Workshop held in Philadelphia, U.S.A., 13-17 July. Eighteen laboratories throughout the world received aliquots of apatite and sphene. To date, analyses by 33 different scientists have been representing 15 different laboratories. With respect to the previous two interlaboratory comparisons, there is a noticeable improvement in the accuracy of the age results (Naeser and Cebula, 1978; Naeser et al., 1981; Miller et al., 1985;Miller et al.1990). Ninety-four percent of the analysis used the external detector method (EDM) combined with the zeta technique while the remaining individuals used the population method (POP). Track length measurements (requested for the first time in the interlaboratory comparison studies) were in relatively good agreement. ?? 1993.

Library orientation methods: J. Hillis Miller Health Center Library program.

PubMed

Eaton, E S

1972-01-01

Two orientation devices are described which are currently in use at the J. Hillis Miller Health Center Library. One is a taped tour which requires a portable recorder with earphones attached. Tapes are now available for nursing students, physical therapy students, and Health Center staff. The tour includes location information and description of the card catalog and certain basic index and abstract services. The second orientation device is a short instruction tape on the use of Index Medicus which is attached to the Index Medicus table. This is heard through a telephone apparatus. It is anticipated that the tape technique will be expanded to apply to other students and other library tools. It is also believed that this technique may be used in other libraries. Information about the supplies and equipment used is given as an addendum.

Better P-curves: Making P-curve analysis more robust to errors, fraud, and ambitious P-hacking, a Reply to Ulrich and Miller (2015).

PubMed

Simonsohn, Uri; Simmons, Joseph P; Nelson, Leif D

2015-12-01

When studies examine true effects, they generate right-skewed p-curves, distributions of statistically significant results with more low (.01 s) than high (.04 s) p values. What else can cause a right-skewed p-curve? First, we consider the possibility that researchers report only the smallest significant p value (as conjectured by Ulrich & Miller, 2015), concluding that it is a very uncommon problem. We then consider more common problems, including (a) p-curvers selecting the wrong p values, (b) fake data, (c) honest errors, and (d) ambitiously p-hacked (beyond p < .05) results. We evaluate the impact of these common problems on the validity of p-curve analysis, and provide practical solutions that substantially increase its robustness. (c) 2015 APA, all rights reserved).

George Miller’s Magical Number of Immediate Memory in Retrospect: Observations on the Faltering Progression of Science

PubMed Central

Cowan, Nelson

2015-01-01

Miller’s (1956) article about storage capacity limits, “The magical number seven plus or minus two…,” is one of the best-known articles in psychology. Though influential in several ways, for about 40 years it was oddly followed by rather little research on the numerical limit of capacity in working memory, or on the relation between three potentially related phenomena that Miller described. Given that the article was written in a humorous tone and was framed around a tongue-in-cheek premise (persecution by an integer), I argue that it may have inadvertently stymied progress on these topics as researchers attempted to avoid ridicule. This commentary relates some correspondence with Miller on his article and concludes with a call to avoid self-censorship of our less conventional ideas. PMID:25751370

Biofunctional properties of Eruca sativa Miller (rocket salad) hydroalcoholic extract.

PubMed

Sultan, Khushbakht; Zakir, Muhammad; Khan, Haroon; Rauf, Abdur; Akber, Noor Ul; Khan, Murad Ali

2016-01-01

Eruca sativa Miller is a worldwide common alimentary plant (rocket leaves). The aim of this study was to correlate the potential in vitro scavenging activity of the E. sativa hydroalcoholic extract (HAE) with its in vivo hypoglycaemic effect. In DDPH free radical (DFR) and ferric-reducing antioxidant power assays, HAE in a concentration dependent manner (25-100 μg/mL) displayed a strong scavenging activity with maximum effect of 88% and 75% at 100 μg/mL, respectively. Daily administration of HAE (50 mg/kg; p.o.) in the in vivo model of alloxan-induced diabetic rabbits for 28 days showed significant reduction in glycaemia, also supported by recovery of body weight. In conclusion, our results give preliminary information on the potential use of this plant as a nutraceutical, useful to control and/or prevent a hyperglycaemic status.

Validity of the Miller forensic assessment of symptoms test in psychiatric inpatients.

PubMed

Veazey, Connie H; Wagner, Alisha L; Hays, J Ray; Miller, Holly A

2005-06-01

This study investigated the validity of the Miller Forensic Assessment of Symptoms Test (M-FAST), a brief measure of malingering, in an inpatient psychiatric sample of 70. Among those patients who also completed the Personality Assessment Inventory (N=44), Total M-FAST score was related in the expected directions to the Personality Assessment Inventory validity scales and indexes, providing evidence for concurrent validity of the M-FAST. With the PAI malingering index used as a criterion, we examined the diagnostic efficiency of the M-FAST and found a cut score of 8 represented the best balance of sensitivity, specificity, positive predictive power, and negative predictive power. Based on this cut-score of 8, 16% of the population was classified as malingering. The M-FAST appears to be an excellent rapid screen for symptom exaggeration in this population and setting.

Organismal death, the dead-donor rule and the ethics of vital organ procurement.

PubMed

Symons, Xavier; Chua, Reginald Mary

2018-06-19

Several bioethicists have recently discussed the complexity of defining human death, and considered in particular how our definition of death affects our understanding of the ethics of vital organ procurement. In this brief paper, we challenge the mainstream medical definition of human death-namely, that death is equivalent to total brain failure-and argue with Nair-Collins and Miller that integrated biological functions can continue even after total brain failure has occurred. We discuss the implications of Nair-Collins and Miller's argument and suggest that it may be necessary to look for alternative biological markers that reliably indicate the death of a human being. We reject the suggestion that we should abandon the dead-donor criteria for organ donation. Rather than weaken the ethical standards for vital organ procurement, it may be necessary to make them more demanding. The aim of this paper is not to justify the dead donor rule. Rather, we aim to explore the perspective of those who agree with critiques of the whole brain and cardiopulmonary definitions of death but yet disagree with the proposal that we should abandon the dead-donor rule. We will consider what those who want to retain the dead-donor rule must argue in light of Nair-Collins and Miller's critique. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Validation of an algorithm to predict reulceration in amputation patients with diabetes.

PubMed

Molines-Barroso, Raúl J; Lázaro-Martínez, José L; Álvaro-Afonso, Francisco J; Sanz-Corbalán, Irene; García-Klepzig, José L; Aragón-Sánchez, Javier

2017-06-01

The aim of this article was to assess the ability to predict reulceration in people with diabetes and a history of minor amputation according to the formula proposed by Miller et al. A retrospective study was performed on 156 consecutive records of patients with a recent history of simple or multiple forefoot amputation. The sample was divided according to Miller's formula into patients at low risk of reulceration and those at high risk; those were further divided into two subgroups according to whether or not the first segment of the forefoot had been amputated. Forty-eight (47·1%) individuals suffered forefoot reulceration, showing a median reulceration-free survival time of 8 months [interquartile range (IR) 3·6-14·8]. Nephropathy (P = 0.005) and Miller's formula (P = 0.028) were risk factors for reulceration-free survival time in the univariate analysis. The pattern relating to the first segment amputated [hazard ratio (HR) 2·853; P = 0·004; 95% confidence interval (CI) 1·391-5·849] and nephropathy (HR 2·468; P = 0.004; 95% CI 1.328-4.587) showed a significant hazard ratio in the multivariate Cox model. Participants with first segment amputation and one other amputation showed an association with the probability of reulceration in comparison with any other specific type of minor amputation. © 2016 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

Chemical Analysis of a "Miller-Type" Complex Prebiotic Broth. Part II: Gas, Oil, Water and the Oil/Water-Interface

NASA Astrophysics Data System (ADS)

Scherer, Sabrina; Wollrab, Eva; Codutti, Luca; Carlomagno, Teresa; da Costa, Stefan Gomes; Volkmer, Andreas; Bronja, Amela; Schmitz, Oliver J.; Ott, Albrecht

2017-12-01

We have analyzed the chemical variety obtained by Miller-Urey-type experiments using nuclear magnetic resonance (NMR) spectroscopy and coherent anti-Stokes Raman scattering (CARS) spectroscopy, gas chromatography followed by mass spectrometry (GC/MS) and two-dimensional gas chromatography followed by mass spectrometry (GCxGC/MS). In the course of a running Miller-Urey-type experiment, a hydrophobic organic layer emerged besides the hydrophilic aqueous phase and the gaseous phase that were initially present. The gas phase mainly consisted of aromatic compounds and molecules containing C≡ C or C≡ N triple bonds. The hydrophilic phase contained at least a few thousands of different molecules, primarily distributed in a range of 50 and 500 Da. The hydrophobic phase is characterized by carbon-rich, oil-like compounds and their amphiphilic derivatives containing oxygen with tensioactive properties. The presence of a wide range of oxidized molecules hints to the availability of oxygen radicals. We suggest that they intervene in the formation of alkylated polyethylene glycol (PEG) in the oil/water interface. CARS spectroscopy revealed distinct vibrational molecular signatures. In particular, characteristic spectral bands for cyanide compounds were observed if the broth was prepared with electric discharges in the gaseous phase. The characteristic spectral bands were absent if discharges were released onto the water surface. NMR spectroscopy on the same set of samples independently confirmed the observation. In addition, NMR spectroscopy revealed overall high chemical variability that suggests strong non-linearities due to interdependent, sequential reaction steps.

Primordial synthesis of amines and amino acids in a 1958 Miller H2S-rich spark discharge experiment

PubMed Central

Parker, Eric T.; Cleaves, Henderson J.; Dworkin, Jason P.; Glavin, Daniel P.; Callahan, Michael; Aubrey, Andrew; Lazcano, Antonio; Bada, Jeffrey L.

2011-01-01

Archived samples from a previously unreported 1958 Stanley Miller electric discharge experiment containing hydrogen sulfide (H2S) were recently discovered and analyzed using high-performance liquid chromatography and time-of-flight mass spectrometry. We report here the detection and quantification of primary amine-containing compounds in the original sample residues, which were produced via spark discharge using a gaseous mixture of H2S, CH4, NH3, and CO2. A total of 23 amino acids and 4 amines, including 7 organosulfur compounds, were detected in these samples. The major amino acids with chiral centers are racemic within the accuracy of the measurements, indicating that they are not contaminants introduced during sample storage. This experiment marks the first synthesis of sulfur amino acids from spark discharge experiments designed to imitate primordial environments. The relative yield of some amino acids, in particular the isomers of aminobutyric acid, are the highest ever found in a spark discharge experiment. The simulated primordial conditions used by Miller may serve as a model for early volcanic plume chemistry and provide insight to the possible roles such plumes may have played in abiotic organic synthesis. Additionally, the overall abundances of the synthesized amino acids in the presence of H2S are very similar to the abundances found in some carbonaceous meteorites, suggesting that H2S may have played an important role in prebiotic reactions in early solar system environments. PMID:21422282

DEVELOPMENT OF AN INSPECTION PLATFORM AND A SUITE OF SENSORS FOR ASSESSING CORROSION AND MECHANICAL DAMAGE ON UNPIGGABLE TRANSMISSION MAINS

DOE Office of Scientific and Technical Information (OSTI.GOV)

George C. Vradis

2003-07-01

This development program is a joint effort among the Northeast Gas Association (formerly New York Gas Group), Foster-Miller, Inc., and the US Department of Energy (DOE) through the National Energy Technology Laboratory (NETL). The DOE's contribution to this project is $572,525 out of a total of $772,525. The present report summarizes the accomplishments of the project during its third three-month period (from April 2003 through June 2003). The project was initiated with delay in February 2003 due to contractual issues that emerged between NGA and Foster-Miller, Inc. The two organizations are working diligently to maintain the program's pace and expectmore » to complete it in time. The efforts of the project focused during this period in finalizing the assessment of the tether technology, which is intended to be used as the means of communication between robot and operator. Results indicate that the tether is a viable option under certain pipeline operating conditions, but not all. Concerns also exist regarding the abrasion resistance of the tether, this issue being the last studied. Substantial work was also conducted on the design of the robotic platform, which has progressed very well. Finally, work on the MFL sensor, able to negotiate all pipeline obstacles (including plug valves), was initiated by PII following the successful completion of the subcontract negotiations between Foster-Miller and PII. The sensor design is at this point the critical path in the project's timetable.« less

Chemical Analysis of a "Miller-Type" Complex Prebiotic Broth : Part II: Gas, Oil, Water and the Oil/Water-Interface.

PubMed

Scherer, Sabrina; Wollrab, Eva; Codutti, Luca; Carlomagno, Teresa; da Costa, Stefan Gomes; Volkmer, Andreas; Bronja, Amela; Schmitz, Oliver J; Ott, Albrecht

2017-12-01

We have analyzed the chemical variety obtained by Miller-Urey-type experiments using nuclear magnetic resonance (NMR) spectroscopy and coherent anti-Stokes Raman scattering (CARS) spectroscopy, gas chromatography followed by mass spectrometry (GC/MS) and two-dimensional gas chromatography followed by mass spectrometry (GCxGC/MS). In the course of a running Miller-Urey-type experiment, a hydrophobic organic layer emerged besides the hydrophilic aqueous phase and the gaseous phase that were initially present. The gas phase mainly consisted of aromatic compounds and molecules containing C≡C or C≡N triple bonds. The hydrophilic phase contained at least a few thousands of different molecules, primarily distributed in a range of 50 and 500 Da. The hydrophobic phase is characterized by carbon-rich, oil-like compounds and their amphiphilic derivatives containing oxygen with tensioactive properties. The presence of a wide range of oxidized molecules hints to the availability of oxygen radicals. We suggest that they intervene in the formation of alkylated polyethylene glycol (PEG) in the oil/water interface. CARS spectroscopy revealed distinct vibrational molecular signatures. In particular, characteristic spectral bands for cyanide compounds were observed if the broth was prepared with electric discharges in the gaseous phase. The characteristic spectral bands were absent if discharges were released onto the water surface. NMR spectroscopy on the same set of samples independently confirmed the observation. In addition, NMR spectroscopy revealed overall high chemical variability that suggests strong non-linearities due to interdependent, sequential reaction steps.

Primordial Synthesis of Amines and Amino Acids in a 1958 Miller H2S-Rich Spark Discharge Experiment

NASA Technical Reports Server (NTRS)

Parker, Eric T.; Cleaves, Henderson J.; Dworkin, Jason P.; Glavin, Daniel P.; Callahan, Michael; Aubrey, Andrew; Lazcano, Antonio; Bada, Jeffrey L.

2011-01-01

Archived samples from a previously unreported 1958 Stanley Miller electric discharge experiment containing hydrogen sulfide (H2S) were recently discovered and analyzed using high-performance liquid chromatography and time-of-flight mass spectrometry. We report here the detection and quantification of primary amine-containing compounds in the original sample residues, which were produced via spark discharge using a gaseous mixture of H2S, CH4, NH3, and CO2. A total of 23 amino acids and 4 amines, including 7 organosulfur compounds, were detected in these samples. The major amino acids with chiral centers are racemic within the accuracy of the measurements, indicating that they are not contaminants introduced during sample storage. This experiment marks the first synthesis of sulfur amino acids from spark discharge experiments designed to imitate primordia! environments. The relative yield of some amino acids, in particular the isomers of aminobutyric acid, are the highest ever found in a spark discharge experiment. The simulated primordial conditions used by Miller may serve as a model for early volcanic plume chemistry and provide insight to the possible roles such plumes may have played in abiotic organic synthesis. Additionally, the overall abundances of the synthesized amino acids in the presence of H2S are very similar to the abundances found in some carbonaceous meteorites, suggesting that H2S may have played an important role in prebiotic reactions in early solar system environments.

Degenerative Changes in the Spine: Is This Arthritis?

MedlinePlus

... refer you to a rheumatologist, physical therapist or orthopedic surgeon. With April Chang-Miller, M.D. Osteoarthritis. ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

Severe Traumatic Brain Injury

MedlinePlus

... but it also has a large societal and economic toll. The estimated economic cost of TBI in 2010, including direct and ... P, Miller T and associates. The Incidence and Economic Burden of Injuries in the United States. New ...

77 FR 44288 - National Space-Based Positioning, Navigation, and Timing (PNT) Advisory Board; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-27

.... James J. Miller, Human Exploration and Operations Mission Directorate, NASA Headquarters, Washington, DC... potential PNT service degradation if adjacent radio-band spectrum interference is introduced. Susan M. Burch...

Orbiting Carbon Observatory Briefing

NASA Image and Video Library

2009-01-29

Charles Miller talks during a media briefing to discuss the upcoming Orbiting Carbon Observatory mission, the first NASA spacecraft dedicated to studying carbon dioxide, Thursday, Jan. 29, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul E. Alers)

Collateral ligament (CL) injury - aftercare

MedlinePlus

... Disorders, Pain, and Rehabilitation . 3rd ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 66. Miller RH, Azar FM. ... eds. Campbell's Operative Orthopaedics . 13th ed. Philadelphia, PA: Elsevier; 2017:chap 45. Niska JA, Petrigliano FA, McAllister ...

Most Recent Sampling Results for Annex III Building

EPA Pesticide Factsheets

Contains email from Scott Miller, US EPA to Scott Kramer. Subject: Most Recent Sampling Results for Annex III Building. (2:52 PM) and Gore(TM) Surveys Analytical Results U.S. Geological Survey, Montgomery, AL.

Dialogue: Manpower Policies for the 70's

ERIC Educational Resources Information Center

New Generation, 1972

1972-01-01

Summarizes the results of a discussion among S. M. Miller, R. D. Corwin, Dennis A. Derryck, Marcia Freedman, Sar Levitan, Jerome Rosow, Robert Schrank, and Elwood Taub on manpower policies for the 1970's. (JM)

Noise & scope study for launch vehicles : final report

DOT National Transportation Integrated Search

2009-03-01

In support of the Federal Aviation Administration (FAA) Office of the Associate Administrator Commercial Space Transportation (AST), the John A. Volpe National Transportation Systems Center (Volpe Center) has retained the services of Harris Miller Mi...

42. Casting floor, "B" furnace, pour in progress; mudgun is ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. Casting floor, "B" furnace, pour in progress; mudgun is to right of furnace; operator takes temperature of iron in trough during pout. Looking south - Rouge Steel Company, 3001 Miller Road, Dearborn, MI

Human Reliability and Ship Stability

DTIC Science & Technology

2003-07-04

models such as Miller (1957) and Broadbent (1959) is the idea of human beings as limited capacity information processors with constraints on...15 4.2.2 Outline of Some Key models ...23 TABLE 11: GENERIC ERROR MODELING SYSTEM

Duplicate of the historic view showing the interior, looking from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Duplicate of the historic view showing the interior, looking from approximately the same vantage point as MD-1109-Q-18 - National Park Seminary, Miller Library, 2801 Woodstock Avenue, Silver Spring, Montgomery County, MD

2017-21 Miller's Son Shine Acres, Inc.

EPA Pesticide Factsheets

The EPA is providing notice of a proposed administrative penalty assessment for alleged violations of the Clean Water Act (Act). The EPA is also providing notice of the opportunity to comment on the proposed penalty assessment.

Congenital Zika Virus Infection: Beyond Neonatal Microcephaly.

PubMed

Melo, Adriana Suely de Oliveira; Aguiar, Renato Santana; Amorim, Melania Maria Ramos; Arruda, Monica B; Melo, Fabiana de Oliveira; Ribeiro, Suelem Taís Clementino; Batista, Alba Gean Medeiros; Ferreira, Thales; Dos Santos, Mayra Pereira; Sampaio, Virgínia Vilar; Moura, Sarah Rogéria Martins; Rabello, Luciana Portela; Gonzaga, Clarissa Emanuelle; Malinger, Gustavo; Ximenes, Renato; de Oliveira-Szejnfeld, Patricia Soares; Tovar-Moll, Fernanda; Chimelli, Leila; Silveira, Paola Paz; Delvechio, Rodrigo; Higa, Luiza; Campanati, Loraine; Nogueira, Rita M R; Filippis, Ana Maria Bispo; Szejnfeld, Jacob; Voloch, Carolina Moreira; Ferreira, Orlando C; Brindeiro, Rodrigo M; Tanuri, Amilcar

2016-12-01

Recent studies have reported an increase in the number of fetuses and neonates with microcephaly whose mothers were infected with the Zika virus (ZIKV) during pregnancy. To our knowledge, most reports to date have focused on select aspects of the maternal or fetal infection and fetal effects. To describe the prenatal evolution and perinatal outcomes of 11 neonates who had developmental abnormalities and neurological damage associated with ZIKV infection in Brazil. We observed 11 infants with congenital ZIKV infection from gestation to 6 months in the state of Paraíba, Brazil. Ten of 11 women included in this study presented with symptoms of ZIKV infection during the first half of pregnancy, and all 11 had laboratory evidence of the infection in several tissues by serology or polymerase chain reaction. Brain damage was confirmed through intrauterine ultrasonography and was complemented by magnetic resonance imaging. Histopathological analysis was performed on the placenta and brain tissue from infants who died. The ZIKV genome was investigated in several tissues and sequenced for further phylogenetic analysis. Description of the major lesions caused by ZIKV congenital infection. Of the 11 infants, 7 (63.6%) were female, and the median (SD) maternal age at delivery was 25 (6) years. Three of 11 neonates died, giving a perinatal mortality rate of 27.3%. The median (SD) cephalic perimeter at birth was 31 (3) cm, a value lower than the limit to consider a microcephaly case. In all patients, neurological impairments were identified, including microcephaly, a reduction in cerebral volume, ventriculomegaly, cerebellar hypoplasia, lissencephaly with hydrocephalus, and fetal akinesia deformation sequence (ie, arthrogryposis). Results of limited testing for other causes of microcephaly, such as genetic disorders and viral and bacterial infections, were negative, and the ZIKV genome was found in both maternal and neonatal tissues (eg, amniotic fluid, cord blood, placenta, and brain). Phylogenetic analyses showed an intrahost virus variation with some polymorphisms in envelope genes associated with different tissues. Combined findings from clinical, laboratory, imaging, and pathological examinations provided a more complete picture of the severe damage and developmental abnormalities caused by ZIKV infection than has been previously reported. The term congenital Zika syndrome is preferable to refer to these cases, as microcephaly is just one of the clinical signs of this congenital malformation disorder.

Theme: Supervised Experience.

ERIC Educational Resources Information Center

Cox, David E.; And Others

1991-01-01

Includes "It's Time to Stop Quibbling over the Acronym" (Cox); "Information Rich--Experience Poor" (Elliot et al.); "Supervised Agricultural Experience Selection Process" (Yokum, Boggs); "Point System" (Fraze, Vaughn); "Urban Diversity Rural Style" (Morgan, Henry); "Nonoccupational Supervised Experience" (Croom); "Reflecting Industry" (Miller);…

Fear and Trembling at Yale

ERIC Educational Resources Information Center

Graff, Gerald

1977-01-01

Discusses the plight of the contemporary literary critic using as examples, Paul de Man, J. Hillis Miller, Harold Bloom, and Geoffrey Hartman. All four men, among the most learned and talented of contemporary critics, reside at Yale University. (Author/RK)

78 FR 70960 - Utah Resource Advisory Council/Recreation Resource Advisory Council Meeting/Conference Call

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... material for the RAC/RRAC to consider during the teleconference, please notify Sherry Foot, Special....S. Forest Service will present fee proposals on the Miller Flat Campground, Orange Olsen Dwelling...

Rigidice Model of Secondary Frost Heave

DOT National Transportation Integrated Search

1995-05-01

A revised version of an earlier attempt to numerically solve Miller's equations for the RIGIDICE model of frost heave is presented that corrects earlier mistakes and incorporates recent improvements in the scaling factors of ground freezing. The new ...

75 FR 60145 - PNT Advisory Board; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-29

... J. Miller, Space Communications and Navigation Program, Space Operations Mission Directorate... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-114)] PNT Advisory Board; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of Meeting. SUMMARY: In accordance with the...

Industrial Relations in Canada: Contemporary Comparisons and Change.

ERIC Educational Resources Information Center

Blyton, Paul; Goodman, John, Eds.

1990-01-01

Includes "Canadian Industrial Relations: An Introductory Overview" (Blyton, Goodman); "Overview of Canadian Labour Law" (Miller); "Industrial Conflict and Resolution in Canada and Britain" (Haiven); "Collective Bargaining in the Public Sector in Canada" (Calvert); "Canadian Automobile Industry: Work…

23. Brick coke quencher, brick stack, metal stack to right, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. Brick coke quencher, brick stack, metal stack to right, coke gas pipe to left; in background, BOF building, limestone piles, Levy's Slag Dump. Looking north/northwest - Rouge Steel Company, 3001 Miller Road, Dearborn, MI

Two Students Win AGU Scholarships

NASA Astrophysics Data System (ADS)

Howard, Claire

2014-10-01

AGU is pleased to announce the winners of two student scholarships. Caterina Brighi is the recipient of the 2014 David S. Miller Young Scientist Scholarship, which recognizes a student of the Earth sciences whose academic work exhibits interest and promise.

Summer Series 2012 - Conversation with Kathy Yelick

ScienceCinema

Yelick, Kathy, Miller, Jeff

2018-05-11

Jeff Miller, head of Public Affairs, sat down in conversation with Kathy Yelick, Associate Berkeley Lab Director, Computing Sciences, in the second of a series of powerpoint-free talks on July 18th 2012, at Berkeley Lab.

Drama and Composition in the Classroom

ERIC Educational Resources Information Center

Urkowitz, Steven

1978-01-01

Reports on the success of a remedial English class that read and performed plays by Euripides, William Shakespeare, and Arthur Miller. Describes the practical details of the course's organization and classroom management that other teachers can adapt. (RL)

Summer Series 2012 - Conversation with Kathy Yelick

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yelick, Kathy, Miller, Jeff

2012-07-23

Jeff Miller, head of Public Affairs, sat down in conversation with Kathy Yelick, Associate Berkeley Lab Director, Computing Sciences, in the second of a series of powerpoint-free talks on July 18th 2012, at Berkeley Lab.

75 FR 27623 - Qualification of Drivers; Exemption Applications; Vision

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-17

.... Askin, Paul J. Bannon, Ernie E. Black, Ronnie F. Bowman, Gary O. Brady, Stephen H. Goldcamp, Steven F. Grass, Wai F. King, Dennis E. Krone, Richard J. McKenzie, Jr., Christopher J. Meerten, Craig W. Miller...

Josh Miller HEARTS Act

THOMAS, 111th Congress

Rep. Sutton, Betty [D-OH-13

2009-03-06

Senate - 06/03/2009 Received in the Senate and Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Josh Miller Helping Everyone Access Responsive Treatment in Schools Act of 2011

THOMAS, 112th Congress

Rep. Sutton, Betty [D-OH-13

2011-04-05

House - 04/15/2011 Referred to the Subcommittee on Early Childhood, Elementary, and Secondary Education. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Duplicate of the historic view showing the exterior of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Duplicate of the historic view showing the exterior of the library from approximately the same vantage point as MD-1109-Q-16 - National Park Seminary, Miller Library, 2801 Woodstock Avenue, Silver Spring, Montgomery County, MD

10. INTERIOR VIEW OF EYE PRESS AREA, SAME AS ABOVE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. INTERIOR VIEW OF EYE PRESS AREA, SAME AS ABOVE WITH MEN AT WORK: CRAIG TSCHAPPAT, HEATER; JEFF MILLER, OPERATOR; JOHN TOTH, SAWMAN - Warwood Tool Company, Foot of Nineteenth Street, Wheeling, Ohio County, WV

Conversations With Albert Einstein. II

ERIC Educational Resources Information Center

Shankland, R. S.

1973-01-01

Discusses Einstein's views on the role of Michelson-Morley, Fizeau, and Miller experiments in the development of relativity and his attitude toward the theories of new quantum mechanics. Indicates that Einstein's opposition to quantum mechanics is beyond dispute. (CC)

Risk and efficacy of human-enabled interspecific hybridization for climate-change adaptation: Response to Hamilton and Miller (2016)

USGS Publications Warehouse

Kovach, Ryan P.; Luikart, Gordon; Lowe, Winsor H.; Boyer, Matthew C.; Muhlfeld, Clint C.

2016-01-01

Hamilton and Miller (2016) provide an interesting and provocative discussion of how hybridization and introgression can promote evolutionary potential in the face of climate change. They argue that hybridization—mating between individuals from genetically distinct populations—can alleviate inbreeding depression and promote adaptive introgression and evolutionary rescue. We agree that deliberate intraspecific hybridization (mating between individuals of the same species) is an underused management tool for increasing fitness in inbred populations (i.e., genetic rescue; Frankham 2015; Whiteley et al. 2015). The potential risks and benefits of assisted gene flow have been discussed in the literature, and an emerging consensus suggests that mating between populations isolated for approximately 50–100 generations can benefit fitness, often with a minor risk of outbreeding depression (Frankham et al. 2011; Aitken & Whitlock 2013; Allendorf et al. 2013).

A Philatelic Ramble through Chemistry (by Edgar Heilbronner and Foil A. Miller)

NASA Astrophysics Data System (ADS)

Rabinovich, Daniel

1998-08-01

Wiley-VCH: New York, 1998. 268 pp. ISBN 3-906390-17-9. $200.00. A philatelic ramble? My Merriam Webster's dictionary says that a ramble is, among other things, a leisurely excursion for pleasure. I think the title of the book under review could not have been more appropriate. A Philatelic Ramble through Chemistry is, indeed, an enjoyable overview of the world of chemistry as pictured on postage stamps and other philatelic materials. More than a thousand (!) color illustrations enhance Heilbronner and Miller's idiosyncratic writing, which combines engaging historical essays with fascinating anecdotes. Although the idea of using stamps in teaching chemistry is not new (see, for example, the "Chemistry on Stamps" series in this Journal in the 1980s), the authors succeed in presenting their stories with unusual charm and wit, aimed at a broad audience, chemists and philatelists alike.

Academic performance, career potential, creativity, and job performance: can one construct predict them all?

PubMed

Kuncel, Nathan R; Hezlett, Sarah A; Ones, Deniz S

2004-01-01

This meta-analysis addresses the question of whether 1 general cognitive ability measure developed for predicting academic performance is valid for predicting performance in both educational and work domains. The validity of the Miller Analogies Test (MAT; W. S. Miller, 1960) for predicting 18 academic and work-related criteria was examined. MAT correlations with other cognitive tests (e.g., Raven's Matrices [J. C. Raven, 1965]; Graduate Record Examinations) also were meta-analyzed. The results indicate that the abilities measured by the MAT are shared with other cognitive ability instruments and that these abilities are generalizably valid predictors of academic and vocational criteria, as well as evaluations of career potential and creativity. These findings contradict the notion that intelligence at work is wholly different from intelligence at school, extending the voluminous literature that supports the broad importance of general cognitive ability (g).

Nicotine promotes rooting in leaf explants of in vitro raised seedlings of tomato, Lycopersicon esculentum Miller var. Pusa Ruby.

PubMed

Bamel, Kiran; Gupta, Rajendra; Gupta, Shrish C

2015-11-01

Nicotine promotes rooting in leaf explants of tomato (Lycopersicon esculentum Miller var. Pusa Ruby). Nicotine at 10(-9) to 10(-3) M concentrations was added to the MS basal medium. The optimum response (three-fold increase in rooting) was obtained at 10(-7) M nicotine-enriched MS medium. At the same level i.e. 10(-7) M Nicotine induced dramatic increase (11-fold) in the number of secondary roots per root. We have shown earlier that exogenous acetylcholine induces a similar response in tomato leaves. Since nicotine is an agonist of one of the two acetylcholine receptors in animals, its ability to simulate ACh action in a plant system suggests the presence of the same molecular mechanism operative in both, animal and plant cells. Copyright © 2015 Elsevier B.V. All rights reserved.

Design considerations of Miller oscillators for high-sensitivity QCM sensors in damping media.

PubMed

Rodriguez-Pardo, Loreto; Fariña, Jose; Gabrielli, Claude; Perrot, Hubert; Brendel, Remi

2007-10-01

In this paper, a new contribution to the design of quartz crystal oscillators for high-sensitivity microbalance sensors used in liquid media is presented. The oscillation condition for a Miller configuration was studied to work in a wide dynamic range of the resonator losses. The equations relating the values of the active and passive components with the maximum supported damping and mass were obtained. Also, the conditions to obtain a stable frequency according to the resonator damping (R(Q)), the static capacity (Cp) and the filter frequency (f(F)) were found. Under these conditions, the circuit oscillation frequency will be proportional to the resonant series frequency and does not depend on the previous parameters (R(Q), f(F), and Cp). If these conditions cannot be satisfied, the expression of the oscillation frequency is given and the discrimination of these effects is obtained through resonator frequency measurements.

Formation of nucleobases in a Miller-Urey reducing atmosphere.

PubMed

Ferus, Martin; Pietrucci, Fabio; Saitta, Antonino Marco; Knížek, Antonín; Kubelík, Petr; Ivanek, Ondřej; Shestivska, Violetta; Civiš, Svatopluk

2017-04-25

The Miller-Urey experiments pioneered modern research on the molecular origins of life, but their actual relevance in this field was later questioned because the gas mixture used in their research is considered too reducing with respect to the most accepted hypotheses for the conditions on primordial Earth. In particular, the production of only amino acids has been taken as evidence of the limited relevance of the results. Here, we report an experimental work, combined with state-of-the-art computational methods, in which both electric discharge and laser-driven plasma impact simulations were carried out in a reducing atmosphere containing NH 3 + CO. We show that RNA nucleobases are synthesized in these experiments, strongly supporting the possibility of the emergence of biologically relevant molecules in a reducing atmosphere. The reconstructed synthetic pathways indicate that small radicals and formamide play a crucial role, in agreement with a number of recent experimental and theoretical results.

Solubility of NaCl in water and its melting point by molecular dynamics in the slab geometry and a new BK3-compatible force field

NASA Astrophysics Data System (ADS)

Kolafa, Jiří

2016-11-01

Saturated concentration of rock salt in water is determined by a simulation of brine in contact with a crystal in the slab geometry. The NaCl crystals are rotated to expose facets with higher Miller indices than [001] to brine. The rock salt melting point is obtained by both the standard and adiabatic simulations in the slab geometry with attention paid to finite size effects as well as to a possible influence of facets with higher Miller indices and applied stress. Two force fields are used, the Lennard-Jones-based model by Young and Cheatham with SPC/E water and the Kiss and Baranyai polarizable model with BK3 water. The latter model is refitted to thermomechanical properties of crystal NaCl leading to better values of solubility and the melting point.

Solubility of NaCl in water and its melting point by molecular dynamics in the slab geometry and a new BK3-compatible force field.

PubMed

Kolafa, Jiří

2016-11-28

Saturated concentration of rock salt in water is determined by a simulation of brine in contact with a crystal in the slab geometry. The NaCl crystals are rotated to expose facets with higher Miller indices than [001] to brine. The rock salt melting point is obtained by both the standard and adiabatic simulations in the slab geometry with attention paid to finite size effects as well as to a possible influence of facets with higher Miller indices and applied stress. Two force fields are used, the Lennard-Jones-based model by Young and Cheatham with SPC/E water and the Kiss and Baranyai polarizable model with BK3 water. The latter model is refitted to thermomechanical properties of crystal NaCl leading to better values of solubility and the melting point.

A Close-Coupled, Heavy Ion ICF Target

NASA Astrophysics Data System (ADS)

Callahan-Miller, Debra A.; Tabak, Max

1998-11-01

A ``close-coupled'' version of the distributed radiator, heavy ion ICF target has produced gain > 130 from 3.1 MJ of ion beam energy. To achieve these results, we reduced the hohlraum dimensions by 27% from our previous designs(M. Tabak, D. Callahan-Miller, D. D.-M. Ho, G. B. Zimmerman, Nuc. Fusion, 38, 509 (1998)) (M. Tabak, D. A. Callahan-Miller, Phys. Plasmas, 5, 1895 (1998).) while driving the same capsule. This reduced the beam energy required from 5.9-6.5 MJ to 3.1 MJ. The smaller hohlraum resulted in a smaller beam spot; elliptically shaped beams with effective radius 1.7 mm were used in this design. In addition to describing this target, we will discuss the effect of the close-coupled hohlraum on the Rayleigh-Taylor instability and scaling this design down to 1.5-2 MJ for an ETF (Engineering Test Facility).

Clinical evaluation of the efficacy of a GTR membrane (HEALIGUIDE) and demineralised bone matrix (OSSEOGRAFT) as a space maintainer in the treatment of Miller's Class I gingival recession.

PubMed

Nanditha, S; Priya, M S; Sabitha, S; Arun, K V; Avaneendra, T

2011-04-01

Periodontal plastic surgical procedures aimed at coverage of exposed root surface have evolved into routine treatment modalities. The present study was designed to evaluate the effectiveness and predictability of using a collagen barrier along with a demineralized bone matrix in the treatment of recession defects in a single surgical procedure. Seventeen patients with Miller's class I recession were treated with a combination of a collagen barrier used along with a bone graft and coronally advanced flap technique. Clinical parameters were recorded at baseline, 3 months, 6 months, and 9 months. The study showed a highly significant reduction in the recession depth (70.29 ± 21.96%) at the end of the study. This study showed that the use of this technique for recession coverage is highly predictable and highly esthetic root coverage can be obtained.

Multiband product rule and consonant identification.

PubMed

Li, Feipeng; Allen, Jont B

2009-07-01

The multiband product rule, also known as band-independence, is a basic assumption of articulation index and its extension, the speech intelligibility index. Previously Fletcher showed its validity for a balanced mix of 20% consonant-vowel (CV), 20% vowel-consonant (VC), and 60% consonant-vowel-consonant (CVC) sounds. This study repeats Miller and Nicely's version of the hi-/lo-pass experiment with minor changes to study band-independence for the 16 Miller-Nicely consonants. The cut-off frequencies are chosen such that the basilar membrane is evenly divided into 12 segments from 250 to 8000 Hz with the high-pass and low-pass filters sharing the same six cut-off frequencies in the middle. Results show that the multiband product rule is statistically valid for consonants on average. It also applies to subgroups of consonants, such as stops and fricatives, which are characterized by a flat distribution of speech cues along the frequency. It fails for individual consonants.

An evaluation of malingering screens with competency to stand trial patients: a known-groups comparison.

PubMed

Vitacco, Michael J; Rogers, Richard; Gabel, Jason; Munizza, Janice

2007-06-01

The assessment of malingering is a fundamental component of forensic evaluations that should be considered with each referral. In systematizing the evaluation of malingering, one option is the standardized administration of screens as an initial step. The current study assessed the effectiveness of three common screening measures: the Miller Forensic Assessment of Symptoms Test (M-FAST; Miller, 2001), the Structured Inventory of Malingered Symptomatology (SIMS; Widows & Smith, 2004), and the Evaluation of Competency to Stand Trial-Revised Atypical Presentation Scale (ECST-R ATP; Rogers, Tillbrook, & Sewell, 2004). Using the Structured Interview of Reported Symptoms (SIRS) as the external criterion, 100 patients involved in competency to stand trial evaluations were categorized as either probable malingerers (n=21) or nonmalingerers (n=79). Each malingering scale produced robust effect sizes in this known-groups comparison. Results are discussed in relation to the comprehensive assessment of malingering within a forensic context.

Electrochemical Measurement of the β-Galactosidase Reporter from Live Cells: A Comparison to the Miller Assay.

PubMed

Tschirhart, Tanya; Zhou, Xinyi Y; Ueda, Hana; Tsao, Chen-Yu; Kim, Eunkyoung; Payne, Gregory F; Bentley, William E

2016-01-15

In order to match our ability to conceive of and construct cells with enhanced function, we must concomitantly develop facile, real-time methods for elucidating performance. With these, new designs can be tested in silico and steps in construction incrementally validated. Electrochemical monitoring offers the above advantages largely because signal transduction stems from direct electron transfer, allowing for potentially quicker and more integrated measurements. One of the most common genetic reporters, β-galactosidase, can be measured both spectrophotometrically (Miller assay) and electrochemically. However, since the relationship between the two is not well understood, the electrochemical methods have not yet garnered the attention of biologists. With the aim of demonstrating the utility of an electrochemical measurement to the synthetic biology community, we created a genetic construct that interprets and reports (with β-galactosidase) on the concentration of the bacterial quorum sensing molecule autoinducer-2. In this work, we provide a correlation between electrochemical measurements and Miller Units. We show that the electrochemical assay works with both lysed and whole cells, allowing for the prediction of one from the other, and for continuous monitoring of cell response. We further present a conceptually simple and generalized mathematical model for cell-based β-galactosidase reporter systems that could aid in building and predicting a variety of synthetic biology constructs. This first-ever in-depth comparison and analysis aims to facilitate the use of electrochemical real-time monitoring in the field of synthetic biology as well as to facilitate the creation of constructs that can more easily communicate information to electronic systems.

The Genyornis Egg: Response to Miller et al.'s commentary on Grellet-Tinner et al., 2016

NASA Astrophysics Data System (ADS)

Grellet-Tinner, Gerald; Spooner, Nigel A.; Handley, Warren D.; Worthy, Trevor H.

2017-04-01

Williams (1981) and Williams and Rich (1991) attributed Australian Quaternary fossil eggshell that differed from that of emu Dromaius novaehollandiae to the extinct bird Genyornis newtoni without any osteological or embryonic support. Such association by proximity or abundance mirrors the case of the mistaken association of oviraptor eggs to Protoceratops in the 1920's by Andrews (Grellet-Tinner and Makovicky, 2006). No other candidate species was considered, and this attribution has been unchallenged and followed by everyone thereafter. Much research has been done on this Australian eggshell, with one result being that the extinction of the parent of this eggshell is the most well documented for a taxon in Australia (e.g., Miller et al., 1999, 2005). Grellet-Tinner et al. (2016) raised several problems with the identity of the eggshell Williams (1981) attributed to Genyornis newtoni and suggested that extinct megapodes of the genus Progura were the more likely layer of this eggshell type, therein referred to as ;putative Genyornis oological material; (PGOM). Miller et al. (2017) challenged our hypothesis stating that ;Based on the dimensions of the reconstructed Spooner Egg,Grellet-Tinner et al. (2016)argue that PGOM is too small for a bird with the body mass estimated for Genyornis (168-275 kg) … …[and] …. None of the additional PGOM observations reported byGrellet-Tinner et al. (2016)are inconsistent with a Genyornis parent;. Here we take the opportunity to respond to their critique, the basis of which resolves into a few points, which we address in turn.

Guillain-Barré Syndrome and Adjuvanted Pandemic Influenza A (H1N1) 2009 Vaccines: A Multinational Self-Controlled Case Series in Europe

PubMed Central

Dieleman, Jeanne P.; Olberg, Henning K.; de Vries, Corinne S.; Sammon, Cormac; Andrews, Nick; Svanström, Henrik; Mølgaard-Nielsen, Ditte; Hviid, Anders; Lapeyre-Mestre, Maryse; Sommet, Agnès; Saussier, Christel; Castot, Anne; Heijbel, Harald; Arnheim-Dahlström, Lisen; Sparen, Par; Mosseveld, Mees; Schuemie, Martijn; van der Maas, Nicoline; Jacobs, Bart C.; Leino, Tuija; Kilpi, Terhi; Storsaeter, Jann; Johansen, Kari; Kramarz, Piotr; Bonhoeffer, Jan; Sturkenboom, Miriam C. J. M.

2014-01-01

Background The risk of Guillain-Barré syndrome (GBS) following the United States' 1976 swine flu vaccination campaign in the USA led to enhanced active surveillance during the pandemic influenza (A(H1N1)pdm09) immunization campaign. This study aimed to estimate the risk of GBS following influenza A(H1N1)pdm09 vaccination. Methods A self-controlled case series (SCCS) analysis was performed in Denmark, Finland, France, Netherlands, Norway, Sweden, and the United Kingdom. Information was collected according to a common protocol and standardised procedures. Cases classified at levels 1–4a of the Brighton Collaboration case definition were included. The risk window was 42 days starting the day after vaccination. Conditional Poisson regression and pooled random effects models estimated adjusted relative incidences (RI). Pseudo likelihood and vaccinated-only methods addressed the potential contraindication for vaccination following GBS. Results Three hundred and three (303) GBS and Miller Fisher syndrome cases were included. Ninety-nine (99) were exposed to A(H1N1)pdm09 vaccination, which was most frequently adjuvanted (Pandemrix and Focetria). The unadjusted pooled RI for A(H1N1)pdm09 vaccination and GBS was 3.5 (95% Confidence Interval (CI): 2.2–5.5), based on all countries. This lowered to 2.0 (95% CI: 1.2–3.1) after adjustment for calendartime and to 1.9 (95% CI: 1.1–3.2) when we accounted for contra-indications. In a subset (Netherlands, Norway, and United Kingdom) we further adjusted for other confounders and there the RI decreased from 1.7 (adjusted for calendar month) to 1.4 (95% CI: 0.7–2.8), which is the main finding. Conclusion This study illustrates the potential of conducting European collaborative vaccine safety studies. The main, fully adjusted analysis, showed that the RI of GBS was not significantly elevated after influenza A(H1N1)pdm09 vaccination (RI = 1.4 (95% CI: 0.7–2.8). Based on the upper limits of the pooled estimate we can rule out with 95% certainty that the number of excess GBS cases after influenza A(H1N1)pdm09 vaccination would be more than 3 per million vaccinated. PMID:24404128

Genetics in the courts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coyle, Heather; Drell, Dan

Various: (1)TriState 2000 Genetics in the Courts (2) Growing impact of the new genetics on the courts (3)Human testing (4) Legal analysis - in re G.C. (5) Legal analysis - GM ''peanots'', and (6) Legal analysis for State vs Miller

Restoring the Savanna to the Savannah River Site.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrington, Timothy B.

2006-07-01

The Longleaf Pine Ecosystem - Ecology, Silviculture, and Restoration. Shibu Jose, Eric J. Jokela, and Deborah L. Miller, (eds.) Springer Series on Environmental Management. Springer Science and Business Media publisher. Chapter 5. Pp 135-156. Chapter 5 of the book.

Motion Sickness Prevention by 8 Hz Stroboscopic Environment during Actual Air Transport

DTIC Science & Technology

2011-09-01

infancy, childhood and adolescence. London: John Libby. Blumenthal, M., Goldberg, A., & Brinkmann, J. 2000. Herbal Medicine: Expanded...Gough, E., Cardenas, R., & Miller, J. C. 2005. Sleep deprivation in humans, immunodepression and glutamine supplementation . University of

9th Annual Safar Symposium

DTIC Science & Technology

2012-07-01

residents, medical students, nursing, pharmacy, and undergraduate trainees. Each trainee presentation was judged by an august group of faculty and a total...Environmental Enrichment-Mediated Functional Improvement After Experimental Traumatic Brain Injury." 62 Megan Miller, BS - " COMT Gene Variant

Science Matters Podcast: Climate Change Research

EPA Pesticide Factsheets

Listen to a podcast with Dr. Andy Miller, the Associate Director for Climate for the Agency's Air, Climate, and Energy Research Program, as he answers questions about climate change research, or read some of the highlights from the conversation here.

NASA Exploration Forum: Human Path to Mars

NASA Image and Video Library

2014-04-29

David Miller, NASA Chief Technologist, participate in a panel discussion during an Exploration Forum showcasing NASA's human exploration path to Mars in the James E. Webb Auditorium at NASA Headquarters on Tuesday, April 29, 2014. Photo Credit: (NASA/Joel Kowsky)

New Teaching Techniques.

ERIC Educational Resources Information Center

Health Education (Washington D.C.), 1985

1985-01-01

Health educators have consistently shown creativity in using innovative teaching techniques. Three articles from the past discuss "new" teaching methods: (1) "A Radio Project Teaches Your Class" (Miller); (2) "An Activity Program in Alcohol Education" (Breg); and (3) "Teaching Health Through Pictures" (Haviland). (CB)

Conceiving Animal Futures.

ERIC Educational Resources Information Center

Brauner, Charles J.

1986-01-01

Reviews "Ethics and Animals" (Miller & Williams, 1983). Maintains that this collection of essays is an excellent example of applied philosophy, showing a profile of philosophy as a force for enlightenment. Reviews the rights of animals and the bases of moral behavior toward them. (JDH)

Annual Report 2005

DTIC Science & Technology

2005-01-01

Program Integration PROJECT LEADERS: Bernard Rostker and Laura Miller 20 RAND National Security Research Division The more intensive use of the...Lim, Laura Werber Castaneda, Daniela Golinelli. MG-196-OSD. NOTE: MG stands for monograph; CF for confer- ence proceedings; CT for congressional

78 FR 21515 - Prevailing Rate Systems; Redefinition of the St. Louis, MO; Southern Missouri; Cleveland, OH; and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-11

... Missouri: Barry Barton Benton Butler Camden Carter Cedar Dade Dallas Dent Douglas Hickory Howell Iron Jasper Lawrence Madison Maries Miller Mississippi Morgan New Madrid Newton Oregon Ozark Polk Reynolds...

Palindromic Rheumatism: Does It Cause Joint Pain?

MedlinePlus

... rheumatoid arthritis? Is palindromic rheumatism a precursor to rheumatoid arthritis? Answers from April Chang-Miller, M.D. About a third of the ... have palindromic rheumatism will go on to develop rheumatoid arthritis. Palindromic rheumatism is characterized by sudden and recurrent ...

Television's New Humane Collectivity.

ERIC Educational Resources Information Center

Schrag, Robert L.; And Others

1981-01-01

Analyzes "Taxi,""Barney Miller,""Lou Grant," and "M*A*S*H" in terms of three fantasy themes: the realization of significant others, the alliance in action, and membership into personhood. From these themes emerges a rhetorical vision of the new humane collectivity. (PD)

Aristotelian Character Education: A Response to Commentators

ERIC Educational Resources Information Center

Kristjánsson, Kristján

2016-01-01

This article contains the responses of the author of Aristotelian Character Education (Routledge, 2015), Kristján Kristjánsson, to responses by three commentators, Randall Curren, Daniel Laspley and Christian Miller, published in this same issue of "JME."

[Central Nervous Involvement in Patients with Fukuyama Congenital Muscular Dystrophy].

PubMed

Ishigaki, Keiko

2016-02-01

Fukuyama congenital muscular dystrophy (FCMD), the second most common muscular dystrophy in the Japanese population, is an autosomal recessive disorder caused by mutations in the fukutin (FKTN) gene. The main features of FCMD are a combination of infantile-onset hypotonia, generalized muscle weakness, eye abnormalities and central nervous system involvement with mental retardation and seizures associated with cortical migration defects. The FKTN gene product is thought to be necessary for maintaining migrating neurons in an immature state during migration, and for supporting migration via α-dystroglycan in the central nervous system. Typical magnetic resonance imaging findings in FCMD patients are cobblestone lissencephaly and cerebellar cystic lesions. White matter abnormalities with hyperintensity on T(2)-weighted images are seen especially in younger patients and those with severe phenotypes. Most FCMD patients are mentally retarded and the level is moderate to severe, with IQs ranging from 30 to 50. In our recent study, 62% of patients developed seizures. Among them, 71% had only febrile seizures, 6% had afebrile seizures from the onset, and 22% developed afebrile seizures following febrile seizures. Most patients had seizures that were controllable with just 1 type of antiepileptic drug, but 18% had intractable seizures that must be treated with 3 medications.

A mechanical model predicts morphological abnormalities in the developing human brain

NASA Astrophysics Data System (ADS)

Budday, Silvia; Raybaud, Charles; Kuhl, Ellen

2014-07-01

The developing human brain remains one of the few unsolved mysteries of science. Advancements in developmental biology, neuroscience, and medical imaging have brought us closer than ever to understand brain development in health and disease. However, the precise role of mechanics throughout this process remains underestimated and poorly understood. Here we show that mechanical stretch plays a crucial role in brain development. Using the nonlinear field theories of mechanics supplemented by the theory of finite growth, we model the human brain as a living system with a morphogenetically growing outer surface and a stretch-driven growing inner core. This approach seamlessly integrates the two popular but competing hypotheses for cortical folding: axonal tension and differential growth. We calibrate our model using magnetic resonance images from very preterm neonates. Our model predicts that deviations in cortical growth and thickness induce morphological abnormalities. Using the gyrification index, the ratio between the total and exposed surface area, we demonstrate that these abnormalities agree with the classical pathologies of lissencephaly and polymicrogyria. Understanding the mechanisms of cortical folding in the developing human brain has direct implications in the diagnostics and treatment of neurological disorders, including epilepsy, schizophrenia, and autism.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Omar Yaghi

In this edited version of the hour long talk, Omar Yaghi, director of the Molecular Foundry, sat down in conversation with Jeff Miller, head of Public Affairs, on July 11th, 2012 to discuss his fascination with the hidden world of chemistry and his work on Metal Organic Frameworks.

75 FR 9415 - Notice of Hearing Schedule; Passenger Vessel Financial Responsibility

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... Inc...... Charles A. Robertson, 15 Chairman & Chief Executive Officer. Carnival Corporation & PLC..... David Bernstein, Senior 15 Vice President & Chief Financial Officer. Crystal Cruises, Inc Ann G. Miller... FEDERAL MARITIME COMMISSION Notice of Hearing Schedule; Passenger Vessel Financial Responsibility...

Nextgen Navy eLearning Tracking

DTIC Science & Technology

2014-12-01

ELEARNING TRACKING by William E. Miller December 2014 Thesis Advisor: Man-Tak Shing Co-Advisor: Arijit Das THIS PAGE INTENTIONALLY LEFT......Navy’s eLearning (NeL) computer-based learning system relies on a Learning Management System (LMS) for content delivery and tracking learning

Married...with Food Allergies | NIH MedlinePlus the Magazine

MedlinePlus

... of this page please turn Javascript on. Feature: Food Allergies Married...with Food Allergies Past Issues / Spring 2011 Table of Contents ... married life together and a common problem—severe food allergies. NIH MedlinePlus magazine’s Naomi Miller caught up ...

28 CFR 79.51 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... including subspecialties such as cardiovascular disease, medical oncology, pulmonary disease) as listed by... Criteria for Claims by Uranium Millers § 79.51 Definitions. (a) Chronic renal disease means the chronic...) Cor pulmonale means heart disease, including hypertrophy of the right ventricle, due to pulmonary...

Genome, Epigenome and RNA sequences of Monozygotic Twins Discordant for Multiple Sclerosis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, Neil

2010-06-02

Neil Miller, Deputy Director of Software Engineering at the National Center for Genome Resources, discusses a monozygotic twin study on June 2, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM.

Cryptography for a High-Assurance Web-Based Enterprise

DTIC Science & Technology

2013-10-01

2. Other Cryptographic services - Java provides many cryptographic services through the Java Cryptography Architecture (JCA) framework. The...id=2125 [7]. Miller, Sandra Kay, Fiber Optic Networks Vulnerable to Attack, Information Security Magazine, November 15, 2006, [8]. José R.C

Ceteacean Social Behavioral Response to Sonar

DTIC Science & Technology

2013-09-30

review). The social context of individual foraging behaviour in long-finned pilot whales (Globicephala melas ). Aoki K, Sakai M, Miller JO, Visser F...during 8 experimental exposures of killer (Orcinus orca), long-finned pilot whale (Globicephala melas ), and sperm whale (Physeter macrocephalus

1. Post card view of the bridge, c. 1910. Post ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Post card view of the bridge, c. 1910. Post card courtesy Carol Poh Miller. Photocopy by Berni Rich, Score Photographers Cleveland, OH - B & O Railroad Bridge Number 464, Spanning Old Ship Canal & Cuyahoga River, Cleveland, Cuyahoga County, OH

Genome, Epigenome and RNA sequences of Monozygotic Twins Discordant for Multiple Sclerosis

ScienceCinema

Miller, Neil

2018-01-22

Neil Miller, Deputy Director of Software Engineering at the National Center for Genome Resources, discusses a monozygotic twin study on June 2, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM.

77 FR 62238 - Alan B. Miller and Universal Health Services; Analysis of Agreement Containing Consent Orders To...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-12

... agreed to hold the to-be- divested assets separate, and to maintain the economic viability, marketability... maintain the economic viability, marketability, and competitiveness of the both the Peak and Mesilla Valley...

What is Supercomputing? A Conversation with Kathy Yelick

ScienceCinema

Yelick, Kathy

2017-12-11

In this highlight video, Jeff Miller, head of Public Affairs, sat down in conversation with Kathy Yelick, Associate Berkeley Lab Director, Computing Sciences, in the second of a series of "powerpoint-free" talks on July 18th 2012, at Berkeley Lab.

SOUTHERN END OF ASSEMBLY PLANT, LOOKING N ON SECOND FLOOR, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SOUTHERN END OF ASSEMBLY PLANT, LOOKING N ON SECOND FLOOR, WHICH DID NOT EXIST ON DURING SHIP BUILDING DAYS. NOTE VEHICLE ELEVATOR. ABOVE AND TO THE LEFT IS SHIP BUILDING BALCONY. - B Building, 3001 Miller Road, Dearborn, MI

What is Supercomputing? A Conversation with Kathy Yelick

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yelick, Kathy

2012-07-23

In this highlight video, Jeff Miller, head of Public Affairs, sat down in conversation with Kathy Yelick, Associate Berkeley Lab Director, Computing Sciences, in the second of a series of "powerpoint-free" talks on July 18th 2012, at Berkeley Lab.

Special Issue: Resumes.

ERIC Educational Resources Information Center

Career Planning and Adult Development Journal, 2002

2002-01-01

Includes "Writing Effective Resumes" (Kursmark); "Writing Cover Letters with Credibility" (Davis); "Career Portfolios" (Miller); "Writing a Top-Flight Vitae" (Orlando); "Converting a Curriculum Vitae to a Resume" (Katz, Morahan); "Special Reports" (Chapman); "Every Job Searcher Needs an e-Resume" (Dixson); "Military Value" (Burns); "Key Words"…

40 CFR 81.326 - Missouri.

Code of Federal Regulations, 2014 CFR

2014-07-01

... County Christina County Clay County Crawford County Dade County Dallas County Dent County Douglas County... County Lawrence County Madison County Maries County McDonald County Miller County Mississippi County... County Christian County Crawford County Dade County Dallas County Dent County Douglas County Dunklin...

40 CFR 81.326 - Missouri.

Code of Federal Regulations, 2013 CFR

2013-07-01

... County Christina County Clay County Crawford County Dade County Dallas County Dent County Douglas County... County Lawrence County Madison County Maries County McDonald County Miller County Mississippi County... County Christian County Crawford County Dade County Dallas County Dent County Douglas County Dunklin...

40 CFR 81.326 - Missouri.

Code of Federal Regulations, 2011 CFR

2011-07-01

... County Christina County Clay County Crawford County Dade County Dallas County Dent County Douglas County... County Lawrence County Madison County Maries County McDonald County Miller County Mississippi County... County Dent County Douglas County Dunklin County Gasconade County Greene County Henry County Hickory...

40 CFR 81.326 - Missouri.

Code of Federal Regulations, 2012 CFR

2012-07-01

... County Christina County Clay County Crawford County Dade County Dallas County Dent County Douglas County... County Lawrence County Madison County Maries County McDonald County Miller County Mississippi County... County Christian County Crawford County Dade County Dallas County Dent County Douglas County Dunklin...

40 CFR 81.326 - Missouri.

Code of Federal Regulations, 2010 CFR

2010-07-01

... County Christina County Clay County Crawford County Dade County Dallas County Dent County Douglas County... County Lawrence County Madison County Maries County McDonald County Miller County Mississippi County... County Christian County Crawford County Dade County Dallas County Dent County Douglas County Dunklin...

Engine's Running, But Where's the Fuel?

NASA Astrophysics Data System (ADS)

2006-01-01

Astronomers have found a relatively tiny galaxy whose black-hole-powered "central engine" is pouring out energy at a rate equal to that of much larger galaxies, and they're wondering how it manages to do so. The astronomers used the National Science Foundation's Very Large Array (VLA) radio telescope and optical telescopes at the Apache Point Observatory to study a galaxy dubbed J170902+641728, more than a billion light-years from Earth. The VLA The Very Large Array CREDIT: NRAO/AUI/NSF (Click on image for VLA gallery) "This thing looks like a quasar in VLA images, but quasars come in big galaxies, not little ones like this," said Neal Miller, an astronomer with the National Radio Astronomy Observatory. In visible-light images, the galaxy is lost in the glare from the bright central engine, but those images place strong limits on the galaxy's size, Miller explained. Miller and Kurt Anderson of New Mexico State University presented their findings to the American Astronomical Society's meeting in Washington, DC. Most galaxies have black holes at their centers. The black hole, a concentration of mass whose gravity is so strong that not even light can escape it, can draw material into itself from the surrounding galaxy. If the black hole has gas or stars to "eat," that process generates large amounts of energy as the infalling gas is compressed and heated to high temperatures. This usually is seen in young galaxies,massive galaxies, or in galaxies that have experienced close encounters with companions, stirring up the material and sending it close enough to the black hole to be gobbled up. The black hole in J170902+641728 is about a million times more massive than the Sun, the astronomers say. Their images show that the galaxy can be no larger than about 2,000 light-years across. Our Milky Way Galaxy is about 100,000 light-years across. "There are other galaxies that are likely to be the same size as this one that have black holes of similar mass. However, their black holes are quiet -- they're not putting out the large amounts of energy we see in this one. We're left to wonder just why this one is so active," Miller said. Answering that question may help astronomers better understand how galaxies and their central black holes are formed. "This galaxy is a rare find -- a tiny galaxy that is still building up the mass of its black hole. It's exciting to find an object that can help us understand this important aspect of galaxy evolution," Miller said. J170902+641728 is part of a cluster of galaxies that the scientists have studied with the VLA, with the 3.5-meter telescope at Apache Point Observatory, and with the Sloan Digital Sky Survey telescope at Apache Point. All these telescopes are in New Mexico. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc. Apache Point Observatory is a facility of the Astrophysical Research Consortium which also manages the Sloan Digital Sky Survey.

Clean Room Facility

NASA Image and Video Library

2016-09-07

NASA Glenn technician Ariana Miller prepares an ultrahigh vacuum chamber used to test the materials used in silicon carbide based sensors and electronics that can operate at extremely high temperatures (500 degrees Celsius and higher) for applications such as sensor systems for aircraft engines and Venus exploration.

29. Coke oven byproduct building "XX" with ammonia stills; powerhouse ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. Coke oven by-product building "XX" with ammonia stills; powerhouse with 8 sisters (stacks) in background; conveyor #20 (with break) on right, pulevrized coal storage bunker on left. Looking north/northwest - Rouge Steel Company, 3001 Miller Road, Dearborn, MI

4. July 1971. AERIAL RECONNAISSANCE II, ERIE RAILWAY SURVEY. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. July 1971. AERIAL RECONNAISSANCE II, ERIE RAILWAY SURVEY. - Erie Railway, Parallel French Creek Bridges, 100 feet South of Millers Station Road, 0.4 mile Northeast of State Route 408, 0.9 mile East of Cambridge Springs, Cambridge Springs, Crawford County, PA

2. July 1971. AERIAL RECONNAISSANCE II, ERIE RAILWAY SURVEY. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. July 1971. AERIAL RECONNAISSANCE II, ERIE RAILWAY SURVEY. - Erie Railway, Parallel French Creek Bridges, 100 feet South of Millers Station Road, 0.4 mile Northeast of State Route 408, 0.9 mile East of Cambridge Springs, Cambridge Springs, Crawford County, PA

3. July 1971. AERIAL RECONNAISSANCE II, ERIE RAILWAY SURVEY. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. July 1971. AERIAL RECONNAISSANCE II, ERIE RAILWAY SURVEY. - Erie Railway, Parallel French Creek Bridges, 100 feet South of Millers Station Road, 0.4 mile Northeast of State Route 408, 0.9 mile East of Cambridge Springs, Cambridge Springs, Crawford County, PA

1. July 1971. AERIAL RECONNAISSANCE II, ERIE RAILWAY SURVEY. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. July 1971. AERIAL RECONNAISSANCE II, ERIE RAILWAY SURVEY. - Erie Railway, Parallel French Creek Bridges, 100 feet South of Millers Station Road, 0.4 mile Northeast of State Route 408, 0.9 mile East of Cambridge Springs, Cambridge Springs, Crawford County, PA

Nondestructive detection of infested chestnuts based on NIR spectroscopy

USDA-ARS?s Scientific Manuscript database

Insect feeding is a significant postharvest problem for processors of Chestnuts (Castanea sativa, Miller). In most cases, damage from insects is 'hidden', i.e. not visually detectable on the fruit surface. Consequently, traditional sorting techniques, including manual sorting, are generally inadequa...

West Europe Report.

DTIC Science & Technology

1986-04-21

the Didacta Association, among others. Mr. Merkle , chairman of the board for Bosch, will [deliver the keynote speech] to the...concerning the Dan-F and Rolf oil fields and the Roar gas field. Incidentally, last year A.P. Miller declared to the Energy Ministry that the company

Annual Report to the Nation on the Status of Cancer, 1975-2014, Featuring Survival

MedlinePlus

... PubMed Google Scholar Angela Mariotto Andrew J Lake Information Management Services, Inc., Rockville, MD Search for other works ... Daniel Miller, Joe Zou, and Steve Scoppa of Information Management Services, Inc., for assistance in compiling the data ...

28 CFR 79.3 - Compensable claim categories under the Act.

Code of Federal Regulations, 2010 CFR

2010-07-01

... contracted lung cancer or certain nonmalignant respiratory diseases after being employed in uranium mines... this part. (5) Millers' claims. For persons who contracted lung cancer, certain nonmalignant respiratory diseases, renal cancer, or chronic renal disease (including nephritis and kidney tubal tissue...

28 CFR 79.3 - Compensable claim categories under the Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... contracted lung cancer or certain nonmalignant respiratory diseases after being employed in uranium mines... this part. (5) Millers' claims. For persons who contracted lung cancer, certain nonmalignant respiratory diseases, renal cancer, or chronic renal disease (including nephritis and kidney tubal tissue...

PHOTOCOPY OF DRAWING (from Cultural Resources Management Program for the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PHOTOCOPY OF DRAWING (from Cultural Resources Management Program for the Environment Management Division, Directorate of Public Works, Fort Benning, Georgia) Delineator unknown. GARAGES - Fort Benning, Building No. 864, 7325 Miller Loop, Main Post, Fort Benning Military Reservation, Chattahoochee County, GA

ELECTROSTATICALLY CHARGED AEROSOL DECONTAMINATION SYSTEM FOR SMALL BUILDING DECONTAMINATION - PHASE I

EPA Science Inventory

Existing decontamination procedures are time-consuming, labor-intensive, and produce low-yielding results, and they have a high risk of personnel exposure and equipment damage. Foster-Miller, Inc., has teamed with Lawrence Livermore National Laboratory and other reagent suppl...

ENVIRONMENTALLY SAFE NO/VOC AUTOMOTIVE COATINGS/PREVENTION AND CONTROLS OF VOCS - PHASE I

EPA Science Inventory

Automotive paints provide reasonable protection against the elements but release substantial amounts of dangerous volatile organic components (VOCs) to the atmosphere during application. Foster-Miller proposes to extend their successful development of No VOC aircraft coatings to ...

75 FR 9424 - Oklahoma; Amendment No. 1 to Notice of an Emergency Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No... AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: This notice amends the notice... Miller, Disaster Assistance Directorate, Federal Emergency Management Agency, 500 C Street, SW...

76 FR 9039 - Missouri; Amendment No. 1 to Notice of an Emergency Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-16

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No... AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: This notice amends the notice... Miller, Disaster Assistance Directorate, Federal Emergency Management Agency, 500 C Street, SW...

Trends in Community Development: Looking Back, Looking Forward.

ERIC Educational Resources Information Center

Miller, Chris; And Others

1990-01-01

Includes "Community Work in the U.K.: Reflections on the 1980s" (Miller, Bryant); "Multiplication and Divisions: Trends in Community Development in Ireland since the 1960s" (Cinneide, Walsh); "Reconstruction to Deconstruction: The Transformation of Community Work in Australia" (Meekosha; Mowbray): "Community…

Obscenity: Three Case Studies.

ERIC Educational Resources Information Center

Kelly, Margie

The Supreme Court's controversial "community standards" ruling in "Miller v. California" (1973) states that for materials to be judged obscene, they no longer need to be "utterly without redeeming social value," but must lack serious literary, artistic, political or scientific value, and that the question of…

Around Marshall

NASA Image and Video Library

1968-02-22

During a visit to the Marshall Space Flight Center (MSFC), the Congressional House Committee on Science and Astronautics toured the S-IVB workshop. Pictured here are MSFC’s Dr. Wernher von Braun (standing) and Congressman Miller, Democratic representative of California (sitting on the ergometer bicycle) inside the workshop.

Safety First

ERIC Educational Resources Information Center

Taft, Darryl

2011-01-01

Ned Miller does not take security lightly. As director of campus safety and emergency management at the Des Moines Area Community College (DMACC), any threat requires serious consideration. As community college administrators adopt a more proactive approach to campus safety, many institutions are experimenting with emerging technologies, including…

Simulations & Case Studies. [SITE 2002 Section].

ERIC Educational Resources Information Center

Seymour, Cathy R., Ed.

This document contains the following papers on simulations and case studies from the SITE (Society for Information Technology & Teacher Education) 2002 conference: "3-D Virtual Classroom Technology" (Kimberly Arseneau Miller, Angela Glod); "Simulated Lesson Design Studios" (Willis Copeland); "Lights, Camera, Integration: Presentation Programs and…

28 CFR 79.3 - Compensable claim categories under the Act.

Code of Federal Regulations, 2012 CFR

2012-07-01

... contracted lung cancer or certain nonmalignant respiratory diseases after being employed in uranium mines... this part. (5) Millers' claims. For persons who contracted lung cancer, certain nonmalignant respiratory diseases, renal cancer, or chronic renal disease (including nephritis and kidney tubal tissue...

28 CFR 79.3 - Compensable claim categories under the Act.

Code of Federal Regulations, 2014 CFR

2014-07-01

... contracted lung cancer or certain nonmalignant respiratory diseases after being employed in uranium mines... this part. (5) Millers' claims. For persons who contracted lung cancer, certain nonmalignant respiratory diseases, renal cancer, or chronic renal disease (including nephritis and kidney tubal tissue...

28 CFR 79.3 - Compensable claim categories under the Act.

Code of Federal Regulations, 2013 CFR

2013-07-01

... contracted lung cancer or certain nonmalignant respiratory diseases after being employed in uranium mines... this part. (5) Millers' claims. For persons who contracted lung cancer, certain nonmalignant respiratory diseases, renal cancer, or chronic renal disease (including nephritis and kidney tubal tissue...

AAHE Bulletin, 1999-2000.

ERIC Educational Resources Information Center

Hendley, Vicky, Ed.

2000-01-01

The 10 issues of this organizational journal provide news columns, calls for proposals, conference information, and several major articles. Articles in this volume include: (1) "New Path, Same Goal: An Interview with Blenda Wilson" (Miller); (2) "Making a Difference: Service Learning as an Activism Catalyst and Community…

Theme: Distance Education.

ERIC Educational Resources Information Center

Whittington, M. Susie, Ed.; And Others

1994-01-01

Includes "Next Best Thing to Being There" (Whittington); "Taking the Distance out of Distance Education" (Miller, King); "Preparing a Course for Distance Delivery" (Newcomb); "Team Teaching via Two-Way Interactive Video" (Nichols, Trout); "Using the Ag Ed Network" (Peal); "Student's Perspective" (Schoellhorn); "Need for Instruction in Agriculture…

Proof Search in an Authorization Logic

DTIC Science & Technology

2009-04-14

and Itay Neeman. DKAL: Distributed-knowledge authorization language. In Proceedings of the 21st IEEE Symposium on Computer Security Foundations (CSF...21), 2008. [33] Yuri Gurevich and Itay Neeman. The logic of infons. Technical report, Microsoft Research, 2009. [34] Joshua S. Hodas and Dale Miller

Division Reports from the 2005 AECT Convention

ERIC Educational Resources Information Center

TechTrends: Linking Research & Practice to Improve Learning, 2006

2006-01-01

The Association for Educational Communication & Technology held its International Convention in Orlando, Florida, October 18-22, 2005. The convention theme was "Exploring the Vision". Division report highlights include: (1) Reflections on a Convention: A Vision Explored (Wes Miller); (2) Definition and Terminology Committee (Al…

Root coverage using subepithelial connective tissue graft with platelet-rich plasma in the treatment of gingival recession: A clinical study

PubMed Central

Srinivas, B. V. V.; Rupa, N.; Halini Kumari, K. V.; Prasad, S. S. V.; Varalakshmi, U.; Sudhakar, K.

2015-01-01

Introduction: The presence of gingival recession associated with an insufficient amount of keratinized tissue may indicate gingival augmentation procedure. It is a multifaceted problem for which several treatment options are available. The most predictable technique used for gingival augmentation is the subepithelial connective tissue graft (SCTG). Platelet-rich plasma (PRP) is an enhanced source of growth factors and helps in accelerated periodontal repair and regeneration. Aims: The aim of this study was to evaluate the efficacy of SCTG along with PRP in the treatment of Miller's class I and II gingival recessions. Materials and Methods: Eleven subjects with Miller's class I and II gingival recessions were treated using SCTG with PRP. Clinical variables, including plaque index, gingival index, recession depth (RD), Recession width (RW), width of the keratinized gingiva, probing pocket depth (PD) and clinical attachment level (CAL) were recorded. Patients were recalled at baseline, 3 months, 6 months and 1-year after surgery and clinical recordings were taken. Root coverage percentage (%) was measured at the end of 1-year. Results: The clinical parameters were analyzed during the follow-up period by repeated measures ANOVA test. Twelve months follow-up results showed significant improvements in all the clinical parameters. Reduction of recession resulted in a significant decrease in CAL, PD, RW and RD at the end of 12 months. A statistically significant gain in width of keratinized gingiva and a mean root coverage of 84.72 ± 19.10 was obtained at the end of 12 months. Conclusion: From the results of this study, it may be concluded that SCTG with PRP is an effective and predictable method to treat miller's class I and II gingival recession. PMID:26538912

Interactive value-based curriculum: a pilot study.

PubMed

Bowman Peterson, Jill M; Duffy, Briar; Duran, Alisa; Gladding, Sophia P

2018-03-06

Current health care costs are unsustainable, with a large percentage of waste attributed to doctor practices. Medical educators are developing curricula to address value-based care (VBC) in education. There is, however, a paucity of curricula and assessments addressing levels higher than 'knows' at the base of Miller's pyramid of assessment. Our objective was to: (1) teach residents the principles of VBC using active learning strategies; and (2) develop and pilot a tool to assess residents' ability to apply principles of VBC at the higher level of 'knows how' on Miller's pyramid. Residents in medicine, medicine-paediatrics and medicine-dermatology participated in a 5-week VBC morning report curriculum using active learning techniques. Early sessions targeted knowledge and later sessions emphasised the application of VBC principles. Medical educators are developing curricula to address value-based care in education RESULTS: Thirty residents attended at least one session and completed both pre- and post-intervention tests, using a newly developed case-based assessment tool featuring a 'waste score' balanced with 'standard of care'. Residents, on average, reduced their waste score from pre-intervention to post-intervention [mean 8.8 (SD 6.3) versus mean 4.7 (SD 4.6), p = 0.001]. For those who reduced their waste score, most maintained or improved their standard of care. Our results suggest that residents may be able to decrease health care waste, with the majority maintaining or improving their management of care in a case-based assessment after participation in the curriculum. We are working to further incorporate VBC principles into more morning reports, and to develop further interventions and assessments to evaluate our residents at higher levels on Miller's pyramid of assessment. © 2018 John Wiley & Sons Ltd and The Association for the Study of Medical Education.

Comparison of supercritical fluid extraction and ultrasound-assisted extraction of fatty acids from quince (Cydonia oblonga Miller) seed using response surface methodology and central composite design.

PubMed

Daneshvand, Behnaz; Ara, Katayoun Mahdavi; Raofie, Farhad

2012-08-24

Fatty acids of Cydonia oblonga Miller cultivated in Iran were obtained by supercritical (carbon dioxide) extraction and ultrasound-assisted extraction methods. The oils were analyzed by capillary gas chromatography using mass spectrometric detections. The compounds were identified according to their retention indices and mass spectra (EI, 70eV). The experimental parameters of SFE such as pressure, temperature, modifier volume, static and dynamic extraction time were optimized using a Central Composite Design (CCD) after a 2(5) factorial design. Pressure and dynamic extraction time had significant effect on the extraction yield, while the other factors (temperature, static extraction time and modifier volume) were not identified as significant factors under the selected conditions. The results of chemometrics analysis showed the highest yield for SFE (24.32%), which was obtained at a pressure of 353bar, temperature of 35°C, modifier (methanol) volume of 150μL, and static and dynamic extraction times of 10 and 60min, respectively. Ultrasound-assisted extraction (UAE) of Fatty acids from C. oblonga Miller was optimized, using a rotatable central composite design. The optimum conditions were as follows: solvent (n-hexane) volume, 22mL; extraction time, 30min; and extraction temperature, 55°C. This resulted in a maximum oil recovery of 19.5%. The extracts with higher yield from both methods were subjected to transesterification and GC-MS analysis. The results show that the oil obtained by SFE with the optimal operating conditions allowed a fatty acid composition similar to the oil obtained by UAE in optimum condition and no significant differences were found. The major components of oil extract were Linoleic, Palmitic, Oleic, Stearic and Eicosanoic acids. Copyright © 2012 Elsevier B.V. All rights reserved.

The Origin of Organic Matter in the Solar System: Evidence from Interplanetary Dust Particles

NASA Technical Reports Server (NTRS)

Flynn, G. J.; Keller, L. P.; Jacobsen, C.; Wirick, S.

2001-01-01

The origin of the organic matter in interplanetary materials has not been established. A variety of mechanisms have been proposed, with two extreme cases being a Fisher-Tropsch type process operating in the gas phase of the solar nebula or a Miller-Urey type process, which requires interaction with an aqueous fluid, presumably occurring on an asteroid. In the Fisher-Tropsch case, we might expect similar organic matter in hydrated and anhydrous interplanetary materials. However, aqueous alteration is required in the case of the Miller-Urey process, and we would expect to see organic matter preferentially in interplanetary materials that exhibit evidence of aqueous activity, such as the presence of hydrated silicates. The types and abundance of organic matter in meteorites have been used as an indicator of the origin of organic matter in the Solar System. Indigenous complex organic matter, including amino acids, has been found in hydrated carbonaceous chondrite meteorites, such as Murchison. Much lower amounts of complex organic matter, possibly only terrestrial contamination, have been found in anhydrous carbonaceous chondrite meteorites, such as Allende, that contain most of their carbon in elemental form. These results seem to favor production of the bulk of the organic matter in the Solar System by aqueous processing on parent bodies such as asteroids, a Miller-Urey process. However, the hydrated carbonaceous chondrite meteorites have approximately solar abundances of the moderately volatile elements, while all anhydrous carbonaceous chondrite meteorites have significantly lower contents of these moderately volatile elements. Two mechanisms, incomplete condensation or evaporation, both of which involve processing at approx. 1200 C, have been suggested to explain the lower content of the moderately volatile elements in all anhydrous meteorites. Additional information is contained in the original extended abstract.