Science.gov

Sample records for mimicking worst-case scenarios

  1. Extreme solar particle events: The worst case scenario

    NASA Astrophysics Data System (ADS)

    Usoskin, Ilya; Kovaltsov, Gennady

    2016-04-01

    Sporadic eruptive energetic events on the Sun may occur during periods of high solar activity. Sometimes such events can be strong or even extreme posing serious hazards for the modern technology and communication dependent society. It is important to asses the worst case scenario for an extreme solar particle event and what the probability of its occurrence. The era of direct scientific exploration of the Sun is short - from few decades to a century, and yet several strong harmful events took place during that time. Can we expect even greater events? How often? What shall we prepare for? In order to answer these questions, one has to rely upon indirect methods by analyzing natural proxy archives. Here we present an overview of the history of extreme solar events in the past, from hundreds to millions of year, based on an analysis of cosmogenic isotopes in terrestrial archives (polar ice cores and tree rings) and in lunar rocks.

  2. 30 CFR 254.47 - Determining the volume of oil of your worst case discharge scenario.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... drilling operations, the size of your worst case discharge scenario is the daily volume possible from an... break. You must calculate this volume as follows: (1) Add the pipeline system leak detection time to...

  3. Reducing Probabilistic Weather Forecasts to the Worst-Case Scenario: Anchoring Effects

    ERIC Educational Resources Information Center

    Joslyn, Susan; Savelli, Sonia; Nadav-Greenberg, Limor

    2011-01-01

    Many weather forecast providers believe that forecast uncertainty in the form of the worst-case scenario would be useful for general public end users. We tested this suggestion in 4 studies using realistic weather-related decision tasks involving high winds and low temperatures. College undergraduates, given the statistical equivalent of the…

  4. Selection of Worst-Case Pesticide Leaching Scenarios for Pesticide Registration

    NASA Astrophysics Data System (ADS)

    Vereecken, H.; Tiktak, A.; Boesten, J.; Vanderborght, J.

    2010-12-01

    The use of pesticides, fertilizers and manure in intensive agriculture may have a negative impact on the quality of ground- and surface water resources. Legislative action has been undertaken in many countries to protect surface and groundwater resources from contamination by surface applied agrochemicals. Of particular concern are pesticides. The registration procedure plays an important role in the regulation of pesticide use in the European Union. In order to register a certain pesticide use, the notifier needs to prove that the use does not entail a risk of groundwater contamination. Therefore, leaching concentrations of the pesticide need to be assessed using model simulations for so called worst-case scenarios. In the current procedure, a worst-case scenario represents a parameterized pesticide fate model for a certain soil and a certain time series of weather conditions that tries to represent all relevant processes such as transient water flow, root water uptake, pesticide transport, sorption, decay and volatilisation as accurate as possible. Since this model has been parameterized for only one soil and weather time series, it is uncertain whether it represents a worst-case condition for a certain pesticide use. We discuss an alternative approach that uses a simpler model that requires less detailed information about the soil and weather conditions but still represents the effect of soil and climate on pesticide leaching using information that is available for the entire European Union. A comparison between the two approaches demonstrates that the higher precision that the detailed model provides for the prediction of pesticide leaching at a certain site is counteracted by its smaller accuracy to represent a worst case condition. The simpler model predicts leaching concentrations less precise at a certain site but has a complete coverage of the area so that it selects a worst-case condition more accurately.

  5. The effects of vehicular exhaust buoyancy during worst case pollution scenarios near roadways

    SciTech Connect

    Held, A.E.; Chang, D.P.Y.; Carroll, J.J.

    1998-12-31

    The California Department of Transportation (CALTRANS) has been using CALINE4, a gaussian finite line-source dispersion model, to estimate air pollutant concentrations near roadways given an estimate of traffic flow rates, vehicular emission factors, roadway geometry, and local meteorology. Modelers have typically used CALINE4 to simulate low wind near parallel thermally stable conditions to estimate a worst case pollution scenario (i.e., highest predicted pollutant concentrations) for a proposed roadway. In October 1995, the University of California, Davis (UCD), in conjunction with the CALTRANS Environmental Program, began a two-year investigation to determine if CALINE4 was adequately predicting CO concentrations during worst case meteorological conditions. Based on physical reasoning and a literature review of several highway dispersion studies conducted in the late 1970`s, it was reasoned that gaussian models may over-predict CO concentrations during worst case scenarios because these models do not adequately parameterize the increased vertical dispersion of pollutants due to vehicular emission buoyancy. To explore the role that exhaust buoyancy plays in roadway pollutant dispersion, a series of experiments were conducted on I-80 (near Sacramento) during winter pre-dawn commute hours. Results of the dispersion studies were inconclusive due to difficulty in capturing sufficiently low wind speed conditions during the sampling effort, however, in a compare-contrast study of field measurements versus CALINE4 predictions it was verified that CALINE4 adequately predicts both the magnitude and qualitative shape of non-worst case pollution scenarios. In addition, based on integrated mass flux from downwind CO concentration and wind profiles it was found that the use of CT-EMFAC, a regional scale emission factor model, overpredicted observed modal emissions by as much as 250 to 480%.

  6. Biomechanical behavior of a cemented ceramic knee replacement under worst case scenarios

    NASA Astrophysics Data System (ADS)

    Kluess, D.; Mittelmeier, W.; Bader, R.

    2009-12-01

    In connection with technological advances in the manufacturing of medical ceramics, a newly developed ceramic femoral component was introduced in total knee arthroplasty (TKA). The motivation to consider ceramics in TKA is based on the allergological and tribological benefits as proven in total hip arthroplasty. Owing to the brittleness and reduced fracture toughness of ceramic materials, the biomechanical performance has to be examined intensely. Apart from standard testing, we calculated the implant performance under different worst case scenarios including malposition, bone defects and stumbling. A finite-element-model was developed to calculate the implant performance in situ. The worst case conditions revealed principal stresses 12.6 times higher during stumbling than during normal gait. Nevertheless, none of the calculated principal stress amounts were above the critical strength of the ceramic material used. The analysis of malposition showed the necessity of exact alignment of the implant components.

  7. Biomechanical behavior of a cemented ceramic knee replacement under worst case scenarios

    NASA Astrophysics Data System (ADS)

    Kluess, D.; Mittelmeier, W.; Bader, R.

    2010-03-01

    In connection with technological advances in the manufacturing of medical ceramics, a newly developed ceramic femoral component was introduced in total knee arthroplasty (TKA). The motivation to consider ceramics in TKA is based on the allergological and tribological benefits as proven in total hip arthroplasty. Owing to the brittleness and reduced fracture toughness of ceramic materials, the biomechanical performance has to be examined intensely. Apart from standard testing, we calculated the implant performance under different worst case scenarios including malposition, bone defects and stumbling. A finite-element-model was developed to calculate the implant performance in situ. The worst case conditions revealed principal stresses 12.6 times higher during stumbling than during normal gait. Nevertheless, none of the calculated principal stress amounts were above the critical strength of the ceramic material used. The analysis of malposition showed the necessity of exact alignment of the implant components.

  8. In vitro model improves the prediction of soil arsenic bioavailability: worst-case scenario.

    PubMed

    Makris, Konstantinos C; Quazi, Shahida; Nagar, Rachana; Sarkar, Dibyendu; Datta, Rupali; Sylvia, Victor L

    2008-08-15

    There is a strong interest in developing an in vitro arsenic (As) model that satisfactorily estimates the variability in in vivo relative oral bioavailability (RBA) measurements. Several in vitro tests have been developed, but none is universally accepted due to their limited success in predicting soil As RBA. A suite of amorphous and crystalline solid As phases were chosen, utilizing a worst-case scenario (WCS) that simulated fasting children's gastric solution chemistry. The objectives of this study were to (i) determine the effects of residence time, pH, and solid-to-solution ratio on As bioaccessibility and speciation in the in vitro gastric test; (ii) provide the fundamental basis for an optimized in vitro model constrained by the WCS; and (iii) validate the optimized in vitro test with the in vivo RBA obtained with BALB/c mice. The gastric pH was the only significant (p < 0.05) factor influencing solid As bioaccessibility. Bioaccessible As retained the oxidation state after its release from the solid into the gastric solution. The optimized in vitro model adequately predicted RBA values for a suite of solid As phases typically encountered in soils, with the exception of aluminum-based solids. This study is an excellent starting point for developing an in vitro test applicable to different As-contaminated soils.

  9. Worst-case scenario approach to the tsunami hazard assessment for the Apulian coasts (southern Italy)

    NASA Astrophysics Data System (ADS)

    Armigliato, Alberto; Pagnoni, Gianluca; Zaniboni, Filippo; Tinti, Stefano

    2014-05-01

    In the framework of the Mediterranean basin, Apulia cannot be counted among the most active areas in terms of earthquake and tsunami activity. Nonetheless, in its northern part, which includes the Gargano peninsula, several earthquakes with magnitudes up to 6.7 occurred historically, some of which were also tsunamigenic. The most famous one is the 30 July 1627 event, which produced extensive inundation in the northern part of Gargano and relevant effects also in some portions of its southern side. Its parent fault is still a matter of debate, since both the inland epicentral location determined by macroseismic studies and the strike-slip dominant focal mechanism inferred from local geology are incompatible with a tsunami excitation capable of producing the effects reported by the coeval sources. Moreover, Apulia is bounded by much more tectonically active and tsunamigenic regions, such as the Dalmatia-Montenegro-Albania coastal belt to the East, the western Hellenic Arc to the South-East and the Calabrian arc to the South-West. Finally, Apulia is located in a strategic position in between eastern and western Europe, involving the installation of crucial international infrastructures, such as the Trans-Adriatic gas pipeline. For all the reasons mentioned above, performing an accurate assessment of the hazard related (at least) to earthquakes and tsunami impact in Apulia represents a need. The OTRIONS project developed a multi-parametric network for this purpose, and in its framework we studied the tsunami hazard along the Apulian coasts by means of a worst-case credible scenario approach. This involved the selection and characterisation of all possible tsunamigenic sources both at local and remote distances: this task was carried out as a shared effort with the Italian national RITMARE project. The recognised sources, mainly retrieved from the published literature and from databases available online, include tectonic faults as well as submarine landslides. The

  10. Possible worst-case tsunami scenarios around the Marmara Sea from combined earthquake and landslide sources

    NASA Astrophysics Data System (ADS)

    Latcharote, Panon; Suppasri, Anawat; Imamura, Fumihiko; Aytore, Betul; Yalciner, Ahmet Cevdet

    2016-12-01

    This study evaluates tsunami hazards in the Marmara Sea from possible worst-case tsunami scenarios that are from submarine earthquakes and landslides. In terms of fault-generated tsunamis, seismic ruptures can propagate along the North Anatolian Fault (NAF), which has produced historical tsunamis in the Marmara Sea. Based on the past studies, which consider fault-generated tsunamis and landslide-generated tsunamis individually, future scenarios are expected to generate tsunamis, and submarine landslides could be triggered by seismic motion. In addition to these past studies, numerical modeling has been applied to tsunami generation and propagation from combined earthquake and landslide sources. In this study, tsunami hazards are evaluated from both individual and combined cases of submarine earthquakes and landslides through numerical tsunami simulations with a grid size of 90 m for bathymetry and topography data for the entire Marmara Sea region and validated with historical observations from the 1509 and 1894 earthquakes. This study implements TUNAMI model with a two-layer model to conduct numerical tsunami simulations, and the numerical results show that the maximum tsunami height could reach 4.0 m along Istanbul shores for a full submarine rupture of the NAF, with a fault slip of 5.0 m in the eastern and western basins of the Marmara Sea. The maximum tsunami height for landslide-generated tsunamis from small, medium, and large of initial landslide volumes (0.15, 0.6, and 1.5 km3, respectively) could reach 3.5, 6.0, and 8.0 m, respectively, along Istanbul shores. Possible tsunamis from submarine landslides could be significantly higher than those from earthquakes, depending on the landslide volume significantly. These combined earthquake and landslide sources only result in higher tsunami amplitudes for small volumes significantly because of amplification within the same tsunami amplitude scale (3.0-4.0 m). Waveforms from all the coasts around the Marmara Sea

  11. Defining the worst case scenario for the Makran Subduction Zone: the 1008 AD tsunami

    NASA Astrophysics Data System (ADS)

    Hoffmann, Goesta

    2016-04-01

    correlated to the 1008 AD earthquake and tsunami inundation. The boulder deposits as well as the archaeological remains testify for a maximum tsunami runup of 15m, exceeding by far the inundation as observed in 1945. We define this as the worst case scenario for the Makran Subduction Zone. However, the return period is rather large (>500 years).

  12. Evacuation planning for plausible worst case inundation scenarios in Honolulu, Hawaii.

    PubMed

    Kim, Karl; Pant, Pradip; Yamashita, Eric

    2015-01-01

    Honolulu is susceptible to coastal flooding hazards. Like other coastal cities, Honolulu&s long-term economic viability and sustainability depends on how well it can adapt to changes in the natural and built environment. While there is a disagreement over the magnitude and extent of localized impacts associated with climate change, it is widely accepted that by 2100 there will be at least a meter in sea level rise (SLR) and an increase in extreme weather events. Increased exposure and vulnerabilities associated with urbanization and location of human activities in coastal areas warrants serious consideration by planners and policy makers. This article has three objectives. First, flooding due to the combined effects of SLR and episodic hydro-meteorological and geophysical events in Honolulu are investigated and the risks to the community are quantified. Second, the risks and vulnerabilities of critical infrastructure and the surface transportation system are described. Third, using the travel demand software, travel distances and travel times for evacuation from inundated areas are modeled. Data from three inundation models were used. The first model simulated storm surge from a category 4 hurricane similar to Hurricane Iniki which devastated the island of Kauai in 1992. The second model estimates inundation based on five tsunamis that struck Hawaii. A 1-m increase in sea level was included in both the hurricane storm surge and tsunami flooding models. The third model used in this article generated a 500-year flood event due to riverine flooding. Using a uniform grid cell structure, the three inundation maps were used to assess the worst case flooding scenario. Based on the flood depths, the ruling hazard (hurricane, tsunami, or riverine flooding) for each grid cell was determined. The hazard layer was analyzed with socioeconomic data layers to determine the impact on vulnerable populations, economic activity, and critical infrastructure. The analysis focused both

  13. Tsunami hazard in the Caribbean: Regional exposure derived from credible worst case scenarios

    NASA Astrophysics Data System (ADS)

    Harbitz, C. B.; Glimsdal, S.; Bazin, S.; Zamora, N.; Løvholt, F.; Bungum, H.; Smebye, H.; Gauer, P.; Kjekstad, O.

    2012-04-01

    The present study documents a high tsunami hazard in the Caribbean region, with several thousands of lives lost in tsunamis and associated earthquakes since the XIXth century. Since then, the coastal population of the Caribbean and the Central West Atlantic region has grown significantly and is still growing. Understanding this hazard is therefore essential for the development of efficient mitigation measures. To this end, we report a regional tsunami exposure assessment based on potential and credible seismic and non-seismic tsunamigenic sources. Regional tsunami databases have been compiled and reviewed, and on this basis five main scenarios have been selected to estimate the exposure. The scenarios comprise two Mw8 earthquake tsunamis (north of Hispaniola and east of Lesser Antilles), two subaerial/submarine volcano flank collapse tsunamis (Montserrat and Saint Lucia), and one tsunami resulting from a landslide on the flanks of the Kick'em Jenny submarine volcano (north of Grenada). Offshore tsunami water surface elevations as well as maximum water level distributions along the shore lines are computed and discussed for each of the scenarios. The number of exposed people has been estimated in each case, together with a summary of the tsunami exposure for the earthquake and the landslide tsunami scenarios. For the earthquake scenarios, the highest tsunami exposure relative to the population is found for Guadeloupe (6.5%) and Antigua (7.5%), while Saint Lucia (4.5%) and Antigua (5%) have been found to have the highest tsunami exposure relative to the population for the landslide scenarios. Such high exposure levels clearly warrant more attention on dedicated mitigation measures in the Caribbean region.

  14. 30 CFR 254.47 - Determining the volume of oil of your worst case discharge scenario.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... determining the daily discharge rate, you must consider reservoir characteristics, casing/production tubing sizes, and historical production and reservoir pressure data. Your scenario must discuss how to respond... uncontrolled blowout. In determining the daily discharge rate, you must consider any known...

  15. Internet Posting of Chemical "Worst Case" Scenarios: A Roadmap for Terrorists

    DTIC Science & Technology

    1999-02-10

    with homework and connect with friends. As a parent, the greatest concern I used to have about the Internet was porn and the other things that sickos...for problems that may or may not exist. Terrorist scenarios are very popular fodder for the press, for movies , for sci-fi writers, and for politicians...when.’’ Such dire forecasts may make for gripping press briefings, movies , and bestsellers, but they do not necessarily make for good policy. As an

  16. Worst case scenario

    SciTech Connect

    Broecker, W.S.

    1997-12-31

    Evidence from paleoarchives clearly demonstrates that the Earth`s climate system must have multiple states of operation which differ greatly in regional temperature, rainfall, and dustiness. Transitions between these states were abrupt occurring in a few decades. During the last 10,000 years, the Earth has been spared of these climate jumps. However during the previous 100,000 years, one such jump occurred two thousand or so years. To date, models of the ocean-atmosphere system have revealed that the oceans` thermohaline circulation is subject to mode switches. But none has captured the large globe-spanning atmospheric changes so clearly revealed in the records kept in ice and sediment. So in adding greenhouse gases to our atmosphere, we poke on ornery beast. Hopefully, this nudge will not cause climate to leap into another of its states.

  17. Worst-Case Scenario Tsunami Hazard Assessment in Two Historically and Economically Important Districts in Eastern Sicily (Italy)

    NASA Astrophysics Data System (ADS)

    Armigliato, A.; Tinti, S.; Pagnoni, G.; Zaniboni, F.; Paparo, M. A.

    2015-12-01

    The portion of the eastern Sicily coastline (southern Italy), ranging from the southern part of the Catania Gulf (to the north) down to the southern-eastern end of the island, represents a very important geographical domain from the industrial, commercial, military, historical and cultural points of view. Here the two major cities of Augusta and Siracusa are found. In particular, the Augusta bay hosts one of the largest petrochemical poles in the Mediterranean, and Siracusa is listed among the UNESCO World Heritage Sites since 2005. This area was hit by at least seven tsunamis in the approximate time interval from 1600 BC to present, the most famous being the 365, 1169, 1693 and 1908 tsunamis. The choice of this area as one of the sites for the testing of innovative methods for tsunami hazard, vulnerability and risk assessment and reduction is then fully justified. This is being developed in the frame of the EU Project called ASTARTE - Assessment, STrategy And Risk Reduction for Tsunamis in Europe (Grant 603839, 7th FP, ENV.2013.6.4-3). We assess the tsunami hazard for the Augusta-Siracusa area through the worst-case credible scenario technique, which can be schematically divided into the following steps: 1) Selection of five main source areas, both in the near- and in the far-field (Hyblaean-Malta escarpment, Messina Straits, Ionian subduction zone, Calabria offshore, western Hellenic Trench); 2) Choice of potential and credible tsunamigenic faults in each area: 38 faults were selected, with properly assigned magnitude, geometry and focal mechanism; 3) Computation of the maximum tsunami wave elevations along the eastern Sicily coast on a coarse grid (by means of the in-house code UBO-TSUFD) and extraction of the 9 scenarios that produce the largest effects in the target areas of Augusta and Siracusa; 4) For each of the 9 scenarios we run numerical UBO-TSUFD simulations over a set of five nested grids, with grid cells size decreasing from 3 km in the open Ionian

  18. EPHECT I: European household survey on domestic use of consumer products and development of worst-case scenarios for daily use.

    PubMed

    Dimitroulopoulou, C; Lucica, E; Johnson, A; Ashmore, M R; Sakellaris, I; Stranger, M; Goelen, E

    2015-12-01

    Consumer products are frequently and regularly used in the domestic environment. Realistic estimates for product use are required for exposure modelling and health risk assessment. This paper provides significant data that can be used as input for such modelling studies. A European survey was conducted, within the framework of the DG Sanco-funded EPHECT project, on the household use of 15 consumer products. These products are all-purpose cleaners, kitchen cleaners, floor cleaners, glass and window cleaners, bathroom cleaners, furniture and floor polish products, combustible air fresheners, spray air fresheners, electric air fresheners, passive air fresheners, coating products for leather and textiles, hair styling products, spray deodorants and perfumes. The analysis of the results from the household survey (1st phase) focused on identifying consumer behaviour patterns (selection criteria, frequency of use, quantities, period of use and ventilation conditions during product use). This can provide valuable input to modelling studies, as this information is not reported in the open literature. The above results were further analysed (2nd phase), to provide the basis for the development of 'most representative worst-case scenarios' regarding the use of the 15 products by home-based population groups (housekeepers and retired people), in four geographical regions in Europe. These scenarios will be used for the exposure and health risk assessment within the EPHECT project. To the best of our knowledge, it is the first time that daily worst-case scenarios are presented in the scientific published literature concerning the use of a wide range of 15 consumer products across Europe.

  19. Coupling atmospheric, hydrological and hydraulic models to develop a catalogue of worst-case scenarios for extreme flooding in Switzerland

    NASA Astrophysics Data System (ADS)

    José Gómez-Navarro, Juan; Felder, Guido; Raible, Christoph C.; Martius, Olivia; Rössler, Ole

    2015-04-01

    the high-resolution simulation (as it is driven by the boundary conditions provided by the GCM), the spatial structure of the precipitation is refined, producing stronger precipitation gradients that allow to identify the main orographic barriers. Further on, much higher precipitation rates occur in some river catchments, which are indicative of potential disastrous situations at very localised regions. In a next step, the results of the atmospheric-alone RCM simulations will be used to drive the hydrological model PREVAH. This model produces event hydrographs, that represent plausible catchment reactions on the simulated precipitation produced by the RCM. The event hydrographs will be then routed with the 1D/2D hydraulic model BASEMENT-ETH, that accounts for the retention effects of lakes and inundated areas. Hence, the described model chain will eventually simulate a number of physically plausible peak discharges in Switzerland that are determined by the most extreme situations occurring in the GCM simulation. This will enable the analysis and characterisation of worst-case floodings in Switzerland whose return period exceeds several centuries.

  20. Assessing oral bioaccessibility of trace elements in soils under worst-case scenarios by automated in-line dynamic extraction as a front end to inductively coupled plasma atomic emission spectrometry.

    PubMed

    Rosende, María; Magalhães, Luis M; Segundo, Marcela A; Miró, Manuel

    2014-09-09

    A novel biomimetic extraction procedure that allows for the in-line handing of ≥400 mg solid substrates is herein proposed for automatic ascertainment of trace element (TE) bioaccessibility in soils under worst-case conditions as per recommendations of ISO norms. A unified bioaccessibility/BARGE method (UBM)-like physiological-based extraction test is evaluated for the first time in a dynamic format for accurate assessment of in-vitro bioaccessibility of Cr, Cu, Ni, Pb and Zn in forest and residential-garden soils by on-line coupling of a hybrid flow set-up to inductively coupled plasma atomic emission spectrometry. Three biologically relevant operational extraction modes mimicking: (i) gastric juice extraction alone; (ii) saliva and gastric juice composite in unidirectional flow extraction format and (iii) saliva and gastric juice composite in a recirculation mode were thoroughly investigated. The extraction profiles of the three configurations using digestive fluids were proven to fit a first order reaction kinetic model for estimating the maximum TE bioaccessibility, that is, the actual worst-case scenario in human risk assessment protocols. A full factorial design, in which the sample amount (400-800 mg), the extractant flow rate (0.5-1.5 mL min(-1)) and the extraction temperature (27-37°C) were selected as variables for the multivariate optimization studies in order to obtain the maximum TE extractability. Two soils of varied physicochemical properties were analysed and no significant differences were found at the 0.05 significance level between the summation of leached concentrations of TE in gastric juice plus the residual fraction and the total concentration of the overall assayed metals determined by microwave digestion. These results showed the reliability and lack of bias (trueness) of the automatic biomimetic extraction approach using digestive juices.

  1. Anticipating and training for the worst-case metabolic scenario: a comment on Del Vecchio, Hirata, and Franchini (2011).

    PubMed

    Amtmann, John

    2012-02-01

    Del Vecchio, Hirata, and Franchini (2011) studied the effort: pause ratio of mixed martial arts by analyzing 26 bouts in two separate mixed martial arts events in Sao Paulo, Brazil. They referenced research identifying effort:pause ratios from other combat sports ranging from 10:1 (Brazilian Jiu Jitsu), 2:1 (judo and wrestling), and 1:3/1:4 (taekwondo). The authors identified an effort:pause ratio ranging from 1:2 to 1:4 in the bouts they analyzed, and suggested and described training programs that resemble this ratio. It is important for coaches to anticipate the most challenging metabolic mixed martial arts scenario and to create training programs that mimic that profile. Del Vecchio and associates' research is an important first step in gathering information which can help enhance training programs for injury prevention and performance enhancement.

  2. The Avellino 3780-yr-B.P. catastrophe as a worst-case scenario for a future eruption at Vesuvius

    PubMed Central

    Mastrolorenzo, Giuseppe; Petrone, Pierpaolo; Pappalardo, Lucia; Sheridan, Michael F.

    2006-01-01

    A volcanic catastrophe even more devastating than the famous anno Domini 79 Pompeii eruption occurred during the Old Bronze Age at Vesuvius. The 3780-yr-B.P. Avellino plinian eruption produced an early violent pumice fallout and a late pyroclastic surge sequence that covered the volcano surroundings as far as 25 km away, burying land and villages. Here we present the reconstruction of this prehistoric catastrophe and its impact on the Bronze Age culture in Campania, drawn from an interdisciplinary volcanological and archaeoanthropological study. Evidence shows that a sudden, en masse evacuation of thousands of people occurred at the beginning of the eruption, before the last destructive plinian column collapse. Most of the fugitives likely survived, but the desertification of the total habitat due to the huge eruption size caused a social–demographic collapse and the abandonment of the entire area for centuries. Because an event of this scale is capable of devastating a broad territory that includes the present metropolitan district of Naples, it should be considered as a reference for the worst eruptive scenario at Vesuvius. PMID:16537390

  3. The Avellino 3780-yr-B.P. catastrophe as a worst-case scenario for a future eruption at Vesuvius.

    PubMed

    Mastrolorenzo, Giuseppe; Petrone, Pierpaolo; Pappalardo, Lucia; Sheridan, Michael F

    2006-03-21

    A volcanic catastrophe even more devastating than the famous anno Domini 79 Pompeii eruption occurred during the Old Bronze Age at Vesuvius. The 3780-yr-B.P. Avellino plinian eruption produced an early violent pumice fallout and a late pyroclastic surge sequence that covered the volcano surroundings as far as 25 km away, burying land and villages. Here we present the reconstruction of this prehistoric catastrophe and its impact on the Bronze Age culture in Campania, drawn from an interdisciplinary volcanological and archaeoanthropological study. Evidence shows that a sudden, en masse evacuation of thousands of people occurred at the beginning of the eruption, before the last destructive plinian column collapse. Most of the fugitives likely survived, but the desertification of the total habitat due to the huge eruption size caused a social-demographic collapse and the abandonment of the entire area for centuries. Because an event of this scale is capable of devastating a broad territory that includes the present metropolitan district of Naples, it should be considered as a reference for the worst eruptive scenario at Vesuvius.

  4. Worst-case scenario approach to the tsunami hazard assessment for the coastal areas between Augusta and Siracusa, eastern Sicily, Italy

    NASA Astrophysics Data System (ADS)

    Armigliato, Alberto; Pagnoni, Gianluca; Zaniboni, Filippo; Tinti, Stefano

    2015-04-01

    The province of Siracusa encompasses a very long portion of the eastern Sicily coastline, ranging from the southern part of the Catania Gulf to the north down to the southern-eastern end of the island, known as Capo Passero. Within this domain, the area comprised between the towns of Augusta and Siracusa has been selected as one of the sites for the testing of innovative methods for tsunami hazard, vulnerability and risk assessment and reduction developed in the frame of the EU Project called ASTARTE - Assessment, STrategy And Risk Reduction for Tsunamis in Europe (Grant 603839, 7th FP, ENV.2013.6.4-3). The selection was driven by two main reasons. First, the area was hit by at least seven tsunamis in the approximate time interval from 1600 BC to present, as can be deduced from historical catalogues and paleo-tsunami deposits analysis: the most famous are probably the 21 July 365, 4 February 1169, 11 January 1693 and 28 December 1908 tsunamis. Secondly, as a whole, the test site has a strong relevance from the industrial, commercial, military, historical and cultural points of view: here it is sufficient to mention the huge petrochemical pole in the Augusta bay and the listing of Siracusa as UNESCO World Heritage Site since 2005. This contribution deals with the tsunami hazard assessment for the Augusta-Siracusa area, approached through the worst-case credible scenario technique. We selected five main source areas: the choice is driven mainly by the already mentioned fact that historical catalogues and paleo-tsunami studies tell us that the area under investigation can be impacted by tsunamis generated both in the near-field and in the far-field. The five areas include the Hyblaean-Malta escarpment and the Messina Straits in the near-field, the western and eastern lobes of the Ionian subduction zone in the intermediate field, and the western Hellenic Trench in the far-field. In each source area, a selection of possible faults was made, whose characteristics and

  5. A critical evaluation of worst case optimization methods for robust intensity-modulated proton therapy planning

    SciTech Connect

    Fredriksson, Albin Bokrantz, Rasmus

    2014-08-15

    Purpose: To critically evaluate and compare three worst case optimization methods that have been previously employed to generate intensity-modulated proton therapy treatment plans that are robust against systematic errors. The goal of the evaluation is to identify circumstances when the methods behave differently and to describe the mechanism behind the differences when they occur. Methods: The worst case methods optimize plans to perform as well as possible under the worst case scenario that can physically occur (composite worst case), the combination of the worst case scenarios for each objective constituent considered independently (objectivewise worst case), and the combination of the worst case scenarios for each voxel considered independently (voxelwise worst case). These three methods were assessed with respect to treatment planning for prostate under systematic setup uncertainty. An equivalence with probabilistic optimization was used to identify the scenarios that determine the outcome of the optimization. Results: If the conflict between target coverage and normal tissue sparing is small and no dose-volume histogram (DVH) constraints are present, then all three methods yield robust plans. Otherwise, they all have their shortcomings: Composite worst case led to unnecessarily low plan quality in boundary scenarios that were less difficult than the worst case ones. Objectivewise worst case generally led to nonrobust plans. Voxelwise worst case led to overly conservative plans with respect to DVH constraints, which resulted in excessive dose to normal tissue, and less sharp dose fall-off than the other two methods. Conclusions: The three worst case methods have clearly different behaviors. These behaviors can be understood from which scenarios that are active in the optimization. No particular method is superior to the others under all circumstances: composite worst case is suitable if the conflicts are not very severe or there are DVH constraints whereas

  6. Less than severe worst case accidents

    SciTech Connect

    Sanders, G.A.

    1996-08-01

    Many systems can provide tremendous benefit if operating correctly, produce only an inconvenience if they fail to operate, but have extreme consequences if they are only partially disabled such that they operate erratically or prematurely. In order to assure safety, systems are often tested against the most severe environments and accidents that are considered possible to ensure either safe operation or safe failure. However, it is often the less severe environments which result in the ``worst case accident`` since these are the conditions in which part of the system may be exposed or rendered unpredictable prior to total system failure. Some examples of less severe mechanical, thermal, and electrical environments which may actually be worst case are described as cautions for others in industries with high consequence operations or products.

  7. 41 CFR 102-80.150 - What is meant by “reasonable worst case fire scenario”?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is meant by âreasonable worst case fire scenarioâ? 102-80.150 Section 102-80.150 Public Contracts and Property Management...-SAFETY AND ENVIRONMENTAL MANAGEMENT Accident and Fire Prevention Reasonable Worst Case Fire...

  8. Specifying design conservatism: Worst case versus probabilistic analysis

    NASA Technical Reports Server (NTRS)

    Miles, Ralph F., Jr.

    1993-01-01

    Design conservatism is the difference between specified and required performance, and is introduced when uncertainty is present. The classical approach of worst-case analysis for specifying design conservatism is presented, along with the modern approach of probabilistic analysis. The appropriate degree of design conservatism is a tradeoff between the required resources and the probability and consequences of a failure. A probabilistic analysis properly models this tradeoff, while a worst-case analysis reveals nothing about the probability of failure, and can significantly overstate the consequences of failure. Two aerospace examples will be presented that illustrate problems that can arise with a worst-case analysis.

  9. Spacecraft electrical potential estimation in worst case environment

    NASA Astrophysics Data System (ADS)

    Toyoda, Kazuhiro

    2016-07-01

    There are no established simulation criteria for the space environment that produces the worst-case spacecraft charging. An ISO New Work Item Proposal entitled Potential Estimation in Worst-Case Environments was approved for ISO TC20/SC14/WG4. One of the aims of this project is to establish a worst-case charging environment for spacecraft charging simulation. In this paper, we compare round-robin simulations using the MUSCAT and Nascap-2k spacecraft charging codes and published measured worst-case GEO charging environments. As originally envisioned, the SPIS code was also to be part of the round-robin. However, SPIS code results are not available at this time. Thus, in this paper, MUSCAT results are compared with Nascap-2k results. In the round-robin simulation, the same spacecraft model is used with the same material properties and simulations are done with the same environments. Finally our round-robin simulation results suggest the worst-case charging GEO spacecraft charging environment that may be used for spacecraft modeling, design, and testing.

  10. 49 CFR 194.105 - Worst case discharge.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the volume. (b) The worst case discharge is the largest volume, in barrels (cubic meters), of the... capacity of the pipeline), plus the largest line drainage volume after shutdown of the line section(s) in the response zone expressed in barrels (cubic meters); or (2) The largest foreseeable discharge...

  11. Improved worst-case and liely accident definition in complex facilities for 40 CFR 68 compliance

    SciTech Connect

    O`Kula, K.R., Taylor, Robert P., Jr; Hang, P.

    1997-04-01

    Many DOE facilities potentially subject to compliance with offsite consequence criteria under the 40 CFR 68 Risk Management Program house significant inventories of toxic and flammable chemicals. The accident progression event tree methodology is suggested as a useful technical basis to define Worst-Case and Alternative Release Scenarios in facilities performing operations beyond simple storage and/or having several barriers between the chemical hazard and the environment. For multiple chemical release scenarios, a chemical mixture methodology should be applied to conservatively define concentration isopleths. In some instances, the region requiring emergency response planning is larger under this approach than if chemicals are treated individually.

  12. 41 CFR 102-80.150 - What is meant by “reasonable worst case fire scenario”?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What is meant by âreasonable worst case fire scenarioâ? 102-80.150 Section 102-80.150 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY...

  13. On the worst case uncertainty and its evaluation

    NASA Astrophysics Data System (ADS)

    Fabbiano, L.; Giaquinto, N.; Savino, M.; Vacca, G.

    2016-02-01

    The paper is a review on the worst case uncertainty (WCU) concept, neglected in the Guide to the Expression of Uncertainty in Measurements (GUM), but necessary for a correct uncertainty assessment in a number of practical cases involving distribution with compact support. First, it is highlighted that the knowledge of the WCU is necessary to choose a sensible coverage factor, associated to a sensible coverage probability: the Maximum Acceptable Coverage Factor (MACF) is introduced as a convenient index to guide this choice. Second, propagation rules for the worst-case uncertainty are provided in matrix and scalar form. It is highlighted that when WCU propagation cannot be computed, the Monte Carlo approach is the only way to obtain a correct expanded uncertainty assessment, in contrast to what can be inferred from the GUM. Third, examples of applications of the formulae to ordinary instruments and measurements are given. Also an example taken from the GUM is discussed, underlining some inconsistencies in it.

  14. Worst case estimation of homology design by convex analysis

    NASA Technical Reports Server (NTRS)

    Yoshikawa, N.; Elishakoff, Isaac; Nakagiri, S.

    1998-01-01

    The methodology of homology design is investigated for optimum design of advanced structures. for which the achievement of delicate tasks by the aid of active control system is demanded. The proposed formulation of homology design, based on the finite element sensitivity analysis, necessarily requires the specification of external loadings. The formulation to evaluate the worst case for homology design caused by uncertain fluctuation of loadings is presented by means of the convex model of uncertainty, in which uncertainty variables are assigned to discretized nodal forces and are confined within a conceivable convex hull given as a hyperellipse. The worst case of the distortion from objective homologous deformation is estimated by the Lagrange multiplier method searching the point to maximize the error index on the boundary of the convex hull. The validity of the proposed method is demonstrated in a numerical example using the eleven-bar truss structure.

  15. Worst-case-based robust beamforming for wireless cooperative networks

    NASA Astrophysics Data System (ADS)

    Zhang, Li; Chen, Haihua; He, Ming

    2014-12-01

    It is known that distributed beamforming techniques can improve the performance of relay networks by using channel state information (CSI). In practical applications, there exist unavoidably estimation errors of the CSI, which results in outage of quality of service (QoS) or overconsumption of transmit power. In this paper, we propose two worst-case-based distributed beamforming techniques that are robust to the channel estimation errors. In the worst-case-based approaches, the worst case in a set that includes the actual case is optimized. Therefore, the performance of the actual case can be guaranteed. In our first approach, the maximal total relay transmit power in the set is minimized subject to the QoS constraint. This distributed beamforming problem can be approximately solved using second-order cone programming (SOCP). In our second method, the worst QoS in the set is maximized subject to the constraints of individual relay transmit powers. It is shown that the resultant problem can be approximately formulated as a quasi-convex problem and can be solved by using a bisection search method. Simulation results show that the proposed beamforming techniques are robust to the CSI errors and there is no outage of QoS or power in the proposed methods.

  16. On the estimation of the worst-case implant-induced RF-heating in multi-channel MRI.

    PubMed

    Córcoles, Juan; Zastrow, Earl; Kuster, Niels

    2017-03-02

    The increasing use of multiple radiofrequency (RF) transmit channels in magnetic resonance imaging (MRI) systems makes it necessary to rigorously assess the risk of RF-induced heating. This risk is especially aggravated with inclusions of medical implants within the body. The worst-case RF-heating scenario is achieved when the local tissue deposition in the at-risk region (generally in the vicinity of the implant electrodes) reaches its maximum value while MRI exposure is compliant with predefined general specific absorption rate (SAR) limits or power requirements. This work first reviews the common approach to estimate the worst-case RF-induced heating in multi-channel MRI environment, based on the maximization of the ratio of two Hermitian forms by solving a generalized eigenvalue problem. It is then shown that the common approach is not rigorous and may lead to an underestimation of the worst-case RF-heating scenario when there is a large number of RF transmit channels and there exist multiple SAR or power constraints to be satisfied. Finally, this work derives a rigorous SAR-based formulation to estimate a preferable worst-case scenario, which is solved by casting a semidefinite programming relaxation of this original non-convex problem, whose solution closely approximates the true worst-case including all SAR constraints. Numerical results for 2, 4, 8, 16, and 32 RF channels in a 3T-MRI volume coil for a patient with a deep-brain stimulator under a head imaging exposure are provided as illustrative examples.

  17. What is the Worst Case for Cavity Decoupling?

    NASA Astrophysics Data System (ADS)

    Leith, W.

    2001-05-01

    A central issue for nuclear monitoring is the possibility that a nuclear test could be conducted while evading identification by international and national monitoring systems. Of several proposed evasion scenarios, decoupling an explosion in a large, deep, underground cavity has received considerable attention. While improvements in monitoring networks and technologies have decreased the event detection threshold in many regions, achievements in underground construction have also increased the feasibility of constructing large caverns that could conceivably be used for nuclear explosion decoupling. The yield range of greatest uncertainty lies between 1 and 10 kt, where underground explosions could be decoupled in salt and perhaps in hard rock. Assuming that full decoupling can be achieved in elongated cavities of moderate aspect ratio (up to 10:1), I have reviewed the literature on large-cavern construction in hard rock and salt (including cost), and the containment of nuclear explosions in these media, with the goal of defining the worst case for cavity decoupling. In thick salt deposits and domes, it is feasible to construct stable cavities of sufficient volume for full decoupling of nuclear tests larger than 10 kt. Salt probably provides an ideal environment for both cavity construction and containment, and it is possible that the cavity would not leak radioactivity for years. However, at 10 kt, the resulting seismic event would be detected and probably identified by regional monitoring networks. Suitable salt deposits are relatively rare and are not present in many countries of nuclear proliferation concern. Salt regions can usually be identified in the literature and by remote sensing, and could conceivably be monitored. In hard rock, construction of cavities of sufficient volume for full decoupling is limited to at most about 10 kt, mainly because of the difficulty in constructing a cavern of sufficient size at depths required for containment, and the

  18. Worst case analysis: Earth sensor assembly for the tropical rainfall measuring mission observatory

    NASA Technical Reports Server (NTRS)

    Conley, Michael P.

    1993-01-01

    This worst case analysis verifies that the TRMMESA electronic design is capable of maintaining performance requirements when subjected to worst case circuit conditions. The TRMMESA design is a proven heritage design and capable of withstanding the most worst case and adverse of circuit conditions. Changes made to the baseline DMSP design are relatively minor and do not adversely effect the worst case analysis of the TRMMESA electrical design.

  19. Measuring worst-case errors in a robot workcell

    SciTech Connect

    Simon, R.W.; Brost, R.C.; Kholwadwala, D.K.

    1997-10-01

    Errors in model parameters, sensing, and control are inevitably present in real robot systems. These errors must be considered in order to automatically plan robust solutions to many manipulation tasks. Lozano-Perez, Mason, and Taylor proposed a formal method for synthesizing robust actions in the presence of uncertainty; this method has been extended by several subsequent researchers. All of these results presume the existence of worst-case error bounds that describe the maximum possible deviation between the robot`s model of the world and reality. This paper examines the problem of measuring these error bounds for a real robot workcell. These measurements are difficult, because of the desire to completely contain all possible deviations while avoiding bounds that are overly conservative. The authors present a detailed description of a series of experiments that characterize and quantify the possible errors in visual sensing and motion control for a robot workcell equipped with standard industrial robot hardware. In addition to providing a means for measuring these specific errors, these experiments shed light on the general problem of measuring worst-case errors.

  20. Preliminary Analysis of Aircraft Loss of Control Accidents: Worst Case Precursor Combinations and Temporal Sequencing

    NASA Technical Reports Server (NTRS)

    Belcastro, Christine M.; Groff, Loren; Newman, Richard L.; Foster, John V.; Crider, Dennis H.; Klyde, David H.; Huston, A. McCall

    2014-01-01

    Aircraft loss of control (LOC) is a leading cause of fatal accidents across all transport airplane and operational classes, and can result from a wide spectrum of hazards, often occurring in combination. Technologies developed for LOC prevention and recovery must therefore be effective under a wide variety of conditions and uncertainties, including multiple hazards, and their validation must provide a means of assessing system effectiveness and coverage of these hazards. This requires the definition of a comprehensive set of LOC test scenarios based on accident and incident data as well as future risks. This paper defines a comprehensive set of accidents and incidents over a recent 15 year period, and presents preliminary analysis results to identify worst-case combinations of causal and contributing factors (i.e., accident precursors) and how they sequence in time. Such analyses can provide insight in developing effective solutions for LOC, and form the basis for developing test scenarios that can be used in evaluating them. Preliminary findings based on the results of this paper indicate that system failures or malfunctions, crew actions or inactions, vehicle impairment conditions, and vehicle upsets contributed the most to accidents and fatalities, followed by inclement weather or atmospheric disturbances and poor visibility. Follow-on research will include finalizing the analysis through a team consensus process, defining future risks, and developing a comprehensive set of test scenarios with correlation to the accidents, incidents, and future risks. Since enhanced engineering simulations are required for batch and piloted evaluations under realistic LOC precursor conditions, these test scenarios can also serve as a high-level requirement for defining the engineering simulation enhancements needed for generating them.

  1. Worst-Case Flutter Margins from F/A-18 Aircraft Aeroelastic Data

    NASA Technical Reports Server (NTRS)

    Lind, Rick; Brenner, Marty

    1997-01-01

    An approach for computing worst-case flutter margins has been formulated in a robust stability framework. Uncertainty operators are included with a linear model to describe modeling errors and flight variations. The structured singular value, micron, computes a stability margin which directly accounts for these uncertainties. This approach introduces a new method of computing flutter margins and an associated new parameter for describing these margins. The micron margins are robust margins which indicate worst-case stability estimates with respect to the defined uncertainty. Worst-case flutter margins are computed for the F/A-18 SRA using uncertainty sets generated by flight data analysis. The robust margins demonstrate flight conditions for flutter may lie closer to the flight envelope than previously estimated by p-k analysis.

  2. 30 CFR 254.47 - Determining the volume of oil of your worst case discharge scenario.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... effect of hydrostatic pressure, gravity, frictional wall forces and other factors; and (3) The daily... by taking into account the effects of hydrostatic pressure, gravity, frictional wall forces,...

  3. 30 CFR 254.47 - Determining the volume of oil of your worst case discharge scenario.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... effect of hydrostatic pressure, gravity, frictional wall forces and other factors; and (3) The daily... by taking into account the effects of hydrostatic pressure, gravity, frictional wall forces,...

  4. 40 CFR 68.25 - Worst-case release scenario analysis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... pool. The volatilization rate (release rate) shall be calculated at the boiling point of the substance... volatilization rate (release rate) shall be calculated at the boiling point of the substance and at the... below their atmospheric boiling point, the volatilization rate shall be calculated at the...

  5. 40 CFR 68.25 - Worst-case release scenario analysis.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... pool. The volatilization rate (release rate) shall be calculated at the boiling point of the substance... volatilization rate (release rate) shall be calculated at the boiling point of the substance and at the... below their atmospheric boiling point, the volatilization rate shall be calculated at the...

  6. 40 CFR 68.25 - Worst-case release scenario analysis.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... pool. The volatilization rate (release rate) shall be calculated at the boiling point of the substance... volatilization rate (release rate) shall be calculated at the boiling point of the substance and at the... below their atmospheric boiling point, the volatilization rate shall be calculated at the...

  7. 40 CFR 68.25 - Worst-case release scenario analysis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... pool. The volatilization rate (release rate) shall be calculated at the boiling point of the substance... volatilization rate (release rate) shall be calculated at the boiling point of the substance and at the... below their atmospheric boiling point, the volatilization rate shall be calculated at the...

  8. 40 CFR 68.25 - Worst-case release scenario analysis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... pool. The volatilization rate (release rate) shall be calculated at the boiling point of the substance... volatilization rate (release rate) shall be calculated at the boiling point of the substance and at the... below their atmospheric boiling point, the volatilization rate shall be calculated at the...

  9. 30 CFR 254.47 - Determining the volume of oil of your worst case discharge scenario.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... capacity of all oil storage tanks and flow lines on the facility. Flow line volume may be estimated; and (2... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Determining the volume of oil of your worst..., REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS...

  10. 40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .../or operated in such a manner that the multiple tanks function as one storage unit (i.e., multiple... plan that tanks with common piping or piping systems are not operated as one unit. If such evidence is... tanks that function as one oil storage unit, the worst case discharge planning volume would be based...

  11. 40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .../or operated in such a manner that the multiple tanks function as one storage unit (i.e., multiple... plan that tanks with common piping or piping systems are not operated as one unit. If such evidence is... tanks that function as one oil storage unit, the worst case discharge planning volume would be based...

  12. 40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .../or operated in such a manner that the multiple tanks function as one storage unit (i.e., multiple... plan that tanks with common piping or piping systems are not operated as one unit. If such evidence is... tanks that function as one oil storage unit, the worst case discharge planning volume would be based...

  13. 40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .../or operated in such a manner that the multiple tanks function as one storage unit (i.e., multiple... plan that tanks with common piping or piping systems are not operated as one unit. If such evidence is... tanks that function as one oil storage unit, the worst case discharge planning volume would be based...

  14. Selection of Thermal Worst-Case Orbits via Modified Efficient Global Optimization

    NASA Technical Reports Server (NTRS)

    Moeller, Timothy M.; Wilhite, Alan W.; Liles, Kaitlin A.

    2014-01-01

    Efficient Global Optimization (EGO) was used to select orbits with worst-case hot and cold thermal environments for the Stratospheric Aerosol and Gas Experiment (SAGE) III. The SAGE III system thermal model changed substantially since the previous selection of worst-case orbits (which did not use the EGO method), so the selections were revised to ensure the worst cases are being captured. The EGO method consists of first conducting an initial set of parametric runs, generated with a space-filling Design of Experiments (DoE) method, then fitting a surrogate model to the data and searching for points of maximum Expected Improvement (EI) to conduct additional runs. The general EGO method was modified by using a multi-start optimizer to identify multiple new test points at each iteration. This modification facilitates parallel computing and decreases the burden of user interaction when the optimizer code is not integrated with the model. Thermal worst-case orbits for SAGE III were successfully identified and shown by direct comparison to be more severe than those identified in the previous selection. The EGO method is a useful tool for this application and can result in computational savings if the initial Design of Experiments (DoE) is selected appropriately.

  15. 40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Determination of a Worst Case Discharge Planning Volume D Appendix D to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... determined by the RA that the facility could cause substantial harm to the environment. The calculation of...

  16. 30 CFR 553.14 - How do I determine the worst case oil-spill discharge volume?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false How do I determine the worst case oil-spill... THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 553.14 How do I determine the worst case oil-spill discharge volume? (a) To...

  17. 30 CFR 253.14 - How do I determine the worst case oil-spill discharge volume?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false How do I determine the worst case oil-spill... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 253.14 How do I determine the worst case oil-spill discharge volume? (a)...

  18. 30 CFR 253.14 - How do I determine the worst case oil-spill discharge volume?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I determine the worst case oil-spill... INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 253.14 How do I determine the worst case oil-spill discharge volume? (a) To calculate the...

  19. 30 CFR 553.14 - How do I determine the worst case oil-spill discharge volume?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false How do I determine the worst case oil-spill... THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 553.14 How do I determine the worst case oil-spill discharge volume? (a) To...

  20. 30 CFR 553.14 - How do I determine the worst case oil-spill discharge volume?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false How do I determine the worst case oil-spill... THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 553.14 How do I determine the worst case oil-spill discharge volume? (a) To...

  1. Type-A Worst-Case Uncertainty for Gaussian noise instruments

    NASA Astrophysics Data System (ADS)

    Arpaia, P.; Baccigalupi, C.; Martino, M.

    2015-07-01

    An analytical type-A approach is proposed for predicting the Worst-Case Uncertainty of a measurement system. In a set of independent observations of the same measurand, modelled as independent- and identically-distributed random variables, the upcoming extreme values (e.g. peaks) can be forecast by only characterizing the measurement system noise level, assumed to be white and Gaussian. Simulation and experimental results are presented to validate the model for a case study on the worst-case repeatability of a pulsed power supply for the klystron modulators of the Compact LInear Collider at CERN. The experimental validation highlights satisfying results for an acquisition system repeatable in the order of ±25 ppm over a bandwidth of 5 MHz.

  2. Space Environment Effects: Model for Emission of Solar Protons (ESP): Cumulative and Worst Case Event Fluences

    NASA Technical Reports Server (NTRS)

    Xapsos, M. A.; Barth, J. L.; Stassinopoulos, E. G.; Burke, E. A.; Gee, G. B.

    1999-01-01

    The effects that solar proton events have on microelectronics and solar arrays are important considerations for spacecraft in geostationary and polar orbits and for interplanetary missions. Designers of spacecraft and mission planners are required to assess the performance of microelectronic systems under a variety of conditions. A number of useful approaches exist for predicting information about solar proton event fluences and, to a lesser extent, peak fluxes. This includes the cumulative fluence over the course of a mission, the fluence of a worst-case event during a mission, the frequency distribution of event fluences, and the frequency distribution of large peak fluxes. Naval Research Laboratory (NRL) and NASA Goddard Space Flight Center, under the sponsorship of NASA's Space Environments and Effects (SEE) Program, have developed a new model for predicting cumulative solar proton fluences and worst-case solar proton events as functions of mission duration and user confidence level. This model is called the Emission of Solar Protons (ESP) model.

  3. Worst case total dose radiation response of 0.35 {micro}m SOI CMOSFETs

    SciTech Connect

    Liu, S.T.; Balster, S.; Sinha, S.; Jenkins, W.C.

    1999-12-01

    Through experimental results and analysis by TSUPREM4/MEDICI simulations, the worst case back gate total dose bias condition is established for body tied SOI NMOSFETs. Utilizing the worst-case bias condition, a recently proposed model that describes the back n-channel threshold voltage shift as a function of total dose, TSUPREM4/MEDICI simulations, and circuit level SPICE simulations, a methodology to model post-rad standby current is developed and presented. This methodology requires the extraction of fundamental starting material/material preparation constants, and then can be utilized to examine post-rad stand-by current at the device and circuit level as function of total dose. Good agreement between experimental results and simulations is demonstrated.

  4. On one-step worst-case optimal trisection in univariate bi-objective Lipschitz optimization

    NASA Astrophysics Data System (ADS)

    Žilinskas, Antanas; Gimbutienė, Gražina

    2016-06-01

    The bi-objective Lipschitz optimization with univariate objectives is considered. The concept of the tolerance of the lower Lipschitz bound over an interval is generalized to arbitrary subintervals of the search region. The one-step worst-case optimality of trisecting an interval with respect to the resulting tolerance is established. The theoretical investigation supports the previous usage of trisection in other algorithms. The trisection-based algorithm is introduced. Some numerical examples illustrating the performance of the algorithm are provided.

  5. Sensitivity of worst-case strom surge considering influence of climate change

    NASA Astrophysics Data System (ADS)

    Takayabu, Izuru; Hibino, Kenshi; Sasaki, Hidetaka; Shiogama, Hideo; Mori, Nobuhito; Shibutani, Yoko; Takemi, Tetsuya

    2016-04-01

    There are two standpoints when assessing risk caused by climate change. One is how to prevent disaster. For this purpose, we get probabilistic information of meteorological elements, from enough number of ensemble simulations. Another one is to consider disaster mitigation. For this purpose, we have to use very high resolution sophisticated model to represent a worst case event in detail. If we could use enough computer resources to drive many ensemble runs with very high resolution model, we can handle these all themes in one time. However resources are unfortunately limited in most cases, and we have to select the resolution or the number of simulations if we design the experiment. Applying PGWD (Pseudo Global Warming Downscaling) method is one solution to analyze a worst case event in detail. Here we introduce an example to find climate change influence on the worst case storm-surge, by applying PGWD to a super typhoon Haiyan (Takayabu et al, 2015). 1 km grid WRF model could represent both the intensity and structure of a super typhoon. By adopting PGWD method, we can only estimate the influence of climate change on the development process of the Typhoon. Instead, the changes in genesis could not be estimated. Finally, we drove SU-WAT model (which includes shallow water equation model) to get the signal of storm surge height. The result indicates that the height of the storm surge increased up to 20% owing to these 150 years climate change.

  6. Performance of FH/BFSK with generalized fading in worst case partial-band Gaussian interference

    NASA Astrophysics Data System (ADS)

    Crepeau, Paul J.

    1990-06-01

    For frequency-hopped (noncoherent) binary frequency shift keying (FH/BFSK) on a worst-case partial-band Gaussian interference channel, the bit error probability results are well known for the extreme cases where the signal is either nonfading or Rayleigh fading. In this work, the region between these extremes is filled in by considering the general Nakagami-m fading model. The worst-case partial-band Gaussian interference results are given by a one-parameter family which for m goes to infinity gives the Viterbi-Jacobs nonfading result, and for m = 1 gives the Rayleigh fading result. In the latter case, a broadband interference strategy is optimal. Thus, the Nakagami-m results provide a smooth one-parameter bridge between the Viterbi-Jacobs channel and the Rayleigh fading channel. The results show that the worst-case interference fraction rho increases as the fading variance increases, up to Rayleigh fading. Any fading less severe than Rayleigh, however slight the departure from Rayleigh, requires a partial-band strategy for sufficiently large Eb/NI.

  7. Multimodal object authentication with random projections: a worst-case approach

    NASA Astrophysics Data System (ADS)

    Koval, Oleksiy; Voloshynovskiy, Sviatoslav

    2010-01-01

    In this paper, we consider a forensic multimodal authentication framework based on binary hypothesis testing in random projections domain. We formulate a generic authentication problem taking into account several possible counterfeiting strategies. The authentication performance analysis is accomplished in the scope of Neyman- Pearson framework as well as for an average probability of error for both direct and random projections domains. Worst-case attack/acquisition channel leading to the worst performance loss in terms of Bhattacharyya distance reduction is presented. The obtained theoretical findings are also confirmed by results of computer simulation.

  8. Worst-Case Prediction of Single-Particle-Induced Permanent Failures in Microelectronics.

    DTIC Science & Technology

    1981-07-01

    ATTN DAMA-RAX, SYS REVIEW & PIIKHAVN NATIONAL LAIROPATORY WASHINGTON, 15’ 20101 ANALYSIS UFC ASS’AIATED, UNIVERSITIES, IN ’ ATTN DAMA- CSS -D, R&D TEAM...CHART NA A l l I i I 666of ,IANIAktl 64 A, V൴ L UNCLASSIFIED 14 ) REPORT DOCUMENTATION PAGE BFRE COSTRUTINSOR Worst-Case Prediction of Single...Washington, DC 20305 IS*. oEcL ASSI F C ATIONOWNGRAING 16. DISTRIBUTION STATEMENT (of this Report ) Approved for public release, distribution unlimited. 17

  9. Discussions On Worst-Case Test Condition For Single Event Burnout

    NASA Astrophysics Data System (ADS)

    Liu, Sandra; Zafrani, Max; Sherman, Phillip

    2011-10-01

    This paper discusses the failure characteristics of single- event burnout (SEB) on power MOSFETs based on analyzing the quasi-stationary avalanche simulation curves. The analyses show the worst-case test condition for SEB would be using the ion that has the highest mass that would result in the highest transient current due to charge deposition and displacement damage. The analyses also show it is possible to build power MOSFETs that will not exhibit SEB even when tested with the heaviest ion, which have been verified by heavy ion test data on SEB sensitive and SEB immune devices.

  10. Comparison of linear and nonlinear programming approaches for "worst case dose" and "minmax" robust optimization of intensity-modulated proton therapy dose distributions.

    PubMed

    Zaghian, Maryam; Cao, Wenhua; Liu, Wei; Kardar, Laleh; Randeniya, Sharmalee; Mohan, Radhe; Lim, Gino

    2017-03-01

    Robust optimization of intensity-modulated proton therapy (IMPT) takes uncertainties into account during spot weight optimization and leads to dose distributions that are resilient to uncertainties. Previous studies demonstrated benefits of linear programming (LP) for IMPT in terms of delivery efficiency by considerably reducing the number of spots required for the same quality of plans. However, a reduction in the number of spots may lead to loss of robustness. The purpose of this study was to evaluate and compare the performance in terms of plan quality and robustness of two robust optimization approaches using LP and nonlinear programming (NLP) models. The so-called "worst case dose" and "minmax" robust optimization approaches and conventional planning target volume (PTV)-based optimization approach were applied to designing IMPT plans for five patients: two with prostate cancer, one with skull-based cancer, and two with head and neck cancer. For each approach, both LP and NLP models were used. Thus, for each case, six sets of IMPT plans were generated and assessed: LP-PTV-based, NLP-PTV-based, LP-worst case dose, NLP-worst case dose, LP-minmax, and NLP-minmax. The four robust optimization methods behaved differently from patient to patient, and no method emerged as superior to the others in terms of nominal plan quality and robustness against uncertainties. The plans generated using LP-based robust optimization were more robust regarding patient setup and range uncertainties than were those generated using NLP-based robust optimization for the prostate cancer patients. However, the robustness of plans generated using NLP-based methods was superior for the skull-based and head and neck cancer patients. Overall, LP-based methods were suitable for the less challenging cancer cases in which all uncertainty scenarios were able to satisfy tight dose constraints, while NLP performed better in more difficult cases in which most uncertainty scenarios were hard to meet

  11. Toward the definition of a new worst-case paradigm for the preclinical evaluation of posterior spine stabilization devices.

    PubMed

    La Barbera, Luigi; Villa, Tomaso

    2017-02-01

    Mechanical reliability tests on posterior spine stabilization devices are based on standard F1717 by the American Society for Testing and Materials, which describes how to assemble the implant with vertebrae-like test blocks in a corpectomy model. A recent study proposed to revise the standard to describe the anatomical worst-case scenario, instead of the average one currently implemented, and introduce the unsupported screw length as a mechanical parameter. This article investigates the implications of such revisions on the endurance properties of an implant already on the market. Experimental fatigue tests demonstrate that the revision of F1717 standard leads to a reduction of 3.2 million cycles in the fatigue strength of the tested implant: this amount is comparable to the run-out number of cycles (5 million cycles) currently recommended. The numerical analysis, validated with static tests and strain gauges, supports the experimental findings and demonstrates that the stress on the implant may increase upon revision up to a 50% on the screw (most recurrent failure mode), with the unsupported screw length contributing alone up to 40%. The revision of ASTM F1717 standard would guarantee higher safety for the implant to test, potentially covering for a wider population of patients.

  12. Phylogenetic diversity, functional trait diversity and extinction: avoiding tipping points and worst-case losses.

    PubMed

    Faith, Daniel P

    2015-02-19

    The phylogenetic diversity measure, ('PD'), measures the relative feature diversity of different subsets of taxa from a phylogeny. At the level of feature diversity, PD supports the broad goal of biodiversity conservation to maintain living variation and option values. PD calculations at the level of lineages and features include those integrating probabilities of extinction, providing estimates of expected PD. This approach has known advantages over the evolutionarily distinct and globally endangered (EDGE) methods. Expected PD methods also have limitations. An alternative notion of expected diversity, expected functional trait diversity, relies on an alternative non-phylogenetic model and allows inferences of diversity at the level of functional traits. Expected PD also faces challenges in helping to address phylogenetic tipping points and worst-case PD losses. Expected PD may not choose conservation options that best avoid worst-case losses of long branches from the tree of life. We can expand the range of useful calculations based on expected PD, including methods for identifying phylogenetic key biodiversity areas.

  13. Preliminary results and worst-case analysis of in patient scoliosis rehabilitation.

    PubMed

    Weiss, H R; Lohschmidt, K; el-Obeidi, N; Verres, C

    1997-01-01

    The purpose of this study was to assess the effectiveness of a scoliosis-specific rehabilitation programme as it is carried out in the Katharina Schroth Spinal Deformities Rehabilitation Center. Physiotherapy in the treatment of scoliosis patients is still regarded as ineffective since the study by the American Orthopedic Association in 1941, which showed that general exercises could not influence the natural history of scoliosis. However, specific exercise programmes were not known in the USA at that time. This preliminary study started in 1989 with the following inclusion criteria: (1) diagnosis of idiopathic scoliosis; (2) risser sign < 4; (3) no treatment other than physiotherapy; (4) first control after 1-3 years during repeated in patient treatment; (5) standing AP radiograph taken not more than 6 months before the first in patient treatment. A total of 181 scoliosis patients, with an average age of 12.7 years and an average angle of curvature of 27% according to Cobb, were included in this study. The average risser sign was 1.4, the average follow-up 33 months. The Cobb angle of the major curve was measured in a standardized way. The results of our preliminary study were compared to natural history as known from literature. For the worst-case analysis additionally a questionnaire was sent to the non-repeaters treated at our centre at the same time (1989 and 1990) as the patient sample described above, taking into account the same inclusion criteria for this patient sample except point 4. Results showed that progression as usually defined (increase in curvature of 5 degrees or more per year) has not been found in the preliminary study. The patient sample of this study was divided into different age groups and different groups of curve magnitude, for comparison with other studies. Additional to the patient sample of the preliminary study, 116 of the patients from the years 1989 and 1990 fulfilled the inclusion criteria of the preliminary study with the

  14. Modelling the long-term evolution of worst-case Arctic oil spills.

    PubMed

    Blanken, Hauke; Tremblay, Louis Bruno; Gaskin, Susan; Slavin, Alexander

    2017-03-15

    We present worst-case assessments of contamination in sea ice and surface waters resulting from hypothetical well blowout oil spills at ten sites in the Arctic Ocean basin. Spill extents are estimated by considering Eulerian passive tracers in the surface ocean of the MITgcm (a hydrostatic, coupled ice-ocean model). Oil in sea ice, and contamination resulting from melting of oiled ice, is tracked using an offline Lagrangian scheme. Spills are initialized on November 1st 1980-2010 and tracked for one year. An average spill was transported 1100km and potentially affected 1.1 million km(2). The direction and magnitude of simulated oil trajectories are consistent with known large-scale current and sea ice circulation patterns, and trajectories frequently cross international boundaries. The simulated trajectories of oil in sea ice match observed ice drift trajectories well. During the winter oil transport by drifting sea ice is more significant than transport with surface currents.

  15. A Worst-Case Approach for On-Line Flutter Prediction

    NASA Technical Reports Server (NTRS)

    Lind, Rick C.; Brenner, Martin J.

    1998-01-01

    Worst-case flutter margins may be computed for a linear model with respect to a set of uncertainty operators using the structured singular value. This paper considers an on-line implementation to compute these robust margins in a flight test program. Uncertainty descriptions are updated at test points to account for unmodeled time-varying dynamics of the airplane by ensuring the robust model is not invalidated by measured flight data. Robust margins computed with respect to this uncertainty remain conservative to the changing dynamics throughout the flight. A simulation clearly demonstrates this method can improve the efficiency of flight testing by accurately predicting the flutter margin to improve safety while reducing the necessary flight time.

  16. Determining worst-case fatigue thresholds for grain-bridging ceramics

    SciTech Connect

    Kruzic, J.J.; Yuan, R.; Canon, R.M.; Ritchie, R.O.

    2002-10-07

    A method for determining worst-case cyclic fatigue thresholds in grain-bridging ceramics by quantifying the role of bridging is demonstrated for a model alumina. Crack-growth properties for both long and short (< 2 mm) cracks emanating from machined notches (root radii, (rho) {approx}; 15 - 150 (mu)m) were investigated. When compared as a function of the applied stress-intensity range (delta K), growth rates (da/dN) were far higher and fatigue thresholds (Delta)KTH were markedly lower with short cracks, with growth being observable at the lowest driving forces for short cracks emanating from razor micronotches ((rho)is approximately equal to 15 (mu)m). For growth rates < 10-8 m/cycle, da/dN vs. (delta)K data for short cracks merged with the steady-state data for long cracks after {approx}2 mm of extension.

  17. Reinforcement Learning of Optimal Supervisor based on the Worst-Case Behavior

    NASA Astrophysics Data System (ADS)

    Kajiwara, Kouji; Yamasaki, Tatsushi

    The supervisory control initiated by Ramadge and Wonham is a framework for logical control of discrete event systems. In the original supervisory control, the costs for occurrence and disabling of events have not been considered. Then, the optimal supervisory control based on quatitative measures has also been studied. This paper proposes a synthesis method of the optimal supervisor based on the worst-case behavior of discrete event systems. We introduce the new value functions for the assigned control patterns. The new value functions are not based on the expected total rewards, but based on the most undesirable event occurrence in the assigned control pattern. In the proposed method, the supervisor learns how to assign the control pattern based on reinforcement learning so as to maximize the value functions. We show the efficiency of the proposed method by computer simulation.

  18. Atmospheric dispersion modeling for the worst-case detonation accident at the proposed Advanced Hydrotest Facility

    SciTech Connect

    Bowen, B.M., LLNL

    1996-10-01

    The Atmospheric Release Advisory Capability (ARAC) was requested to estimate credible worst-case dose, air concentration, and deposition of airborne hazardous materials that would result from a worst-case detonation accident at the proposed Advanced Hydrotest Facility (AHT) at the Nevada Test Site (NTS). Consequences were estimated at the closest onsite facility, the Device Assembly Facility (DOFF), and offsite location (intersection of Highway and U.S. 95). The materials considered in this analysis were weapon-grade plutonium, beryllium, and hydrogen fluoride which is a combustion product whose concentration is dependent upon the quantity of high explosives. The analysis compares the calculated results with action guidelines published by the Department of Defense in DoD 5100.52-M (Nuclear Weapon Accident Response Procedures). Results indicate that based on a one kg release of plutonium the whole body radiation dose could be as high as 3 Rem at the DOFF. This level approaches the 5 Rem level for which the Department of Defense requires respiratory protection, recommends sheltering and the consideration of evacuation. Deposition levels at the DOFF could approach 6 uCi/m{sup 2} for which the Department of Defense recommends access on a need-only basis and suggests that a possible controlled evacuation might be required. For a one kg release of plutonium, the dose at the nearest off-site location could reach 0.5. At this level, the Department of Defense suggests that sheltering be considered. For a one kg release of beryllium, the peak 5-minute concentration at the DOFF could be as as 20% of 6xlO{sup -3} mg/m{sup 2} which is the applicable by Response Planning Guideline (ERPG-1). At the nearest offsite location, the beryllium concentrations from a one kg release would be two orders of magnitude less than the same guideline. For the detonation of 100 kg of the explosive LX-17, the concentration of hydrogen fluoride at both the DOFF and the nearest offsite location

  19. Worst-Case" Simulant for INTEC Soduim-Bearing Waste Vitrification Tests

    SciTech Connect

    Christian, Jerry Dale; Batcheller, Thomas Aquinas

    2001-09-01

    The Idaho Nuclear Technology and Engineering Center (INTEC) is developing technologies to process the radioactive liquid sodium-bearing waste from the waste tanks at INTEC to solidify the waste into a form suitable for disposition in a National high-level waste repository currently being considered at Yucca Mountain, Nevada. The requirement is for a qualified glass waste form. Therefore, vitrification is being developed using laboratory, research-scale, and pilot scale melters. While some laboratory experiments can be done with actual waste, the larger scale and most laboratory experiments must be done on non-radioactive simulant waste solutions. Some tests have previously been done on simulants of a representative waste that has been concentrated and will remain unchanged in tank WM-180 until it is vitrified. However, there is a need to develop glass compositions that will accommodate all future wastes in the tanks. Estimates of those future waste compositions have been used along with current compositions to develop a “worst-case” waste composition and a simulant preparation recipe suitable for developing a bracketing glass formulation and for characterizing the flowpath and decontamination factors of pertinent off-gas constituents in the vitrification process. The considerations include development of criteria for a worst-case composition. In developing the criteria, the species that are known to affect vitrification and glass properties were considered. Specific components that may need to be characterized in the off-gas cleanup system were considered in relation to detection limits that would need to be exceeded in order to track those components. Chemical aspects of various constituent interactions that should be taken into account when a component may need to be increased in concentration from that in the actual waste for detection in experiments were evaluated. The worst-case waste simulant composition is comprised of the highest concentration of each

  20. Incremental Multi-Scale Search Algorithm for Dynamic Path Planning With Low Worst-Case Complexity.

    PubMed

    Yibiao Lu; Xiaoming Huo; Arslan, O; Tsiotras, P

    2011-12-01

    Path-planning (equivalently, path-finding) problems are fundamental in many applications, such as transportation, VLSI design, robot navigation, and many more. In this paper, we consider dynamic shortest path-planning problems on a graph with a single endpoint pair and with potentially changing edge weights over time. Several algorithms exist in the literature that solve this problem, notably among them the Lifelong Planning algorithm. The algorithm is an incremental search algorithm that replans the path when there are changes in the environment. In numerical experiments, however, it was observed that the performance of is sensitive in the number of vertex expansions required to update the graph when an edge weight value changes or when a vertex is added or deleted. Although, in most cases, the classical requires a relatively small number of updates, in some other cases the amount of work required by the to find the optimal path can be overwhelming. To address this issue, in this paper, we propose an extension of the baseline algorithm, by making efficient use of a multiscale representation of the environment. This multiscale representation allows one to quickly localize the changed edges, and subsequently update the priority queue efficiently. This incremental multiscale ( for short) algorithm leads to an improvement both in terms of robustness and computational complexity-in the worst case-when compared to the classical . Numerical experiments validate the aforementioned claims.

  1. Comparison of temporal realistic telecommunication base station exposure with worst-case estimation in two countries.

    PubMed

    Mahfouz, Zaher; Verloock, Leen; Joseph, Wout; Tanghe, Emmeric; Gati, Azeddine; Wiart, Joe; Lautru, David; Hanna, Victor Fouad; Martens, Luc

    2013-12-01

    The influence of temporal daily exposure to global system for mobile communications (GSM) and universal mobile telecommunications systems and high speed downlink packet access (UMTS-HSDPA) is investigated using spectrum analyser measurements in two countries, France and Belgium. Temporal variations and traffic distributions are investigated. Three different methods to estimate maximal electric-field exposure are compared. The maximal realistic (99 %) and the maximal theoretical extrapolation factor used to extrapolate the measured broadcast control channel (BCCH) for GSM and the common pilot channel (CPICH) for UMTS are presented and compared for the first time in the two countries. Similar conclusions are found in the two countries for both urban and rural areas: worst-case exposure assessment overestimates realistic maximal exposure up to 5.7 dB for the considered example. In France, the values are the highest, because of the higher population density. The results for the maximal realistic extrapolation factor at the weekdays are similar to those from weekend days.

  2. Zero-moment point determination of worst-case manoeuvres leading to vehicle wheel lift

    NASA Astrophysics Data System (ADS)

    Lapapong, S.; Brown, A. A.; Swanson, K. S.; Brennan, S. N.

    2012-01-01

    This paper proposes a method to evaluate vehicle rollover propensity based on a frequency-domain representation of the zero-moment point (ZMP). Unlike other rollover metrics such as the static stability factor, which is based on the steady-state behaviour, and the load transfer ratio, which requires the calculation of tyre forces, the ZMP is based on a simplified kinematic model of the vehicle and the analysis of the contact point of the vehicle relative to the edge of the support polygon. Previous work has validated the use of the ZMP experimentally in its ability to predict wheel lift in the time domain. This work explores the use of the ZMP in the frequency domain to allow a chassis designer to understand how operating conditions and vehicle parameters affect rollover propensity. The ZMP analysis is then extended to calculate worst-case sinusoidal manoeuvres that lead to untripped wheel lift, and the analysis is tested across several vehicle configurations and compared with that of the standard Toyota J manoeuvre.

  3. SU-E-T-642: PTV Is the Voxel-Wise Worst-Case of CTV in Prostate Photon Therapy

    SciTech Connect

    Harrington, D; Schild, S; Wong, W; Vora, S; Liu, W

    2015-06-15

    Purpose: To examine the adequacy of the planning target volume (PTV) dose distribution as the worst-case representation of clinical target volume (CTV) dose distribution in prostate volumetric-modulated arc therapy (VMAT) plans. Methods: Ten intact prostate cancer cases treated by VMAT at our institution were randomly selected. Isocenter was shifted in the three cardinal directions by a displacement equal to the PTV expansion on the CTV (±3 mm) for a total of six shifted plans per original plan. Rotationally-perturbed plans were generated with a couch rotation of ±1° to simulate patient yaw. The eight perturbed dose distributions were recalculated in the treatment planning system using the same, fixed fluence map as the original plan. The voxel-wise worst-case CTV dose distribution was constructed from the minimum value per voxel from the eight perturbed doses. The resulting dose volume histograms (DVH) were evaluated for statistical correlation between the worst-case CTV and nominal PTV dose distributions based on D95% by Wilcoxon signed-rank test with significance level p ≤ 0.05. Results: Inspection demonstrates the PTV DVH in the nominal dose distribution is bounded by the CTV DVH in the worst-case dose distribution. Comparison of D95% for the two dose distributions by Wilcoxon signed-rank test gives p = 0.131. Therefore the null hypothesis cannot be rejected since the difference in median values is not statistically significant. Conclusion: The assumption that the nominal dose distribution for PTV represents the worst-case dose distribution for CTV appears valid for the ten plans under examination. Although the worst-case dose distribution is unphysical since the dose per voxel is chosen independently, it serves as a lower bound for the possible CTV coverage. Furthermore, this is consistent with the unphysical nature of the PTV. Minor discrepancies between the two dose distributions are expected since the dose cloud is not strictly static. Funding Support

  4. The MacArthur Maze Fire and Roadway Collapse: A "Worst Case Scenario" for Spent Nuclear Fuel Transportation?

    SciTech Connect

    Bajwa, Christopher S.; Easton, Earl P.; Adkins, Harold E.; Cuta, Judith M.; Klymyshyn, Nicholas A.; Suffield, Sarah R.

    2012-07-06

    In 2007, a severe transportation accident occurred near Oakland, California, at the interchange known as the "MacArthur Maze." The accident involved a double tanker truck of gasoline overturning and bursting into flames. The subsequent fire reduced the strength of the supporting steel structure of an overhead interstate roadway causing the collapse of portions of that overpass onto the lower roadway in less than 20 minutes. The US Nuclear Regulatory Commission has analyzed what might have happened had a spent nuclear fuel transportation package been involved in this accident, to determine if there are any potential regulatory implications of this accident to the safe transport of spent nuclear fuel in the United States. This paper provides a summary of this effort, presents preliminary results and conclusions, and discusses future work related to the NRC's analysis of the consequences of this type of severe accident.

  5. Accuracy of the cosmic-ray soil water content probe in humid forest ecosystems: The worst case scenario

    NASA Astrophysics Data System (ADS)

    Bogena, H. R.; Huisman, J. A.; Baatz, R.; Hendricks Franssen, H.-J.; Vereecken, H.

    2013-09-01

    Soil water content is one of the key state variables in the soil-vegetation-atmosphere continuum due to its important role in the exchange of water and energy at the soil surface. A new promising method to measure integral soil water content at the field or small catchment scale is the cosmic-ray probe (CRP). Recent studies of CRP measurements have mainly presented results from test sites located in very dry areas and from agricultural fields with sandy soils. In this study, distributed continuous soil water content measurements from a wireless sensor network (SoilNet) were used to investigate the accuracy of CRP measurements for soil water content determination in a humid forest ecosystem. Such ecosystems are less favorable for CRP applications due to the presence of a litter layer. In addition, lattice water and carbohydrates of soil organic matter and belowground biomass reduce the effective sensor depth and thus were accounted for in the calibration of the CRP. The hydrogen located in the biomass decreased the level of neutron count rates and thus also decreased the sensitivity of the cosmic-ray probe, which in turn resulted in an increase of the measurement uncertainty. This uncertainty was compensated by using longer integration times (e.g., 24 h). For the Wüstebach forest site, the cosmic-ray probe enabled the assessment of integral daily soil water content dynamics with a RMSE of about 0.03 cm3/cm3 without explicitly considering the litter layer. By including simulated water contents of the litter layer in the calibration, a better accuracy could be achieved.

  6. Worst-Case Cooperative Jamming for Secure Communications in CIoT Networks

    PubMed Central

    Li, Zhen; Jing, Tao; Ma, Liran; Huo, Yan; Qian, Jin

    2016-01-01

    The Internet of Things (IoT) is a significant branch of the ongoing advances in the Internet and mobile communications. Yet, the use of a large number of IoT devices can severely worsen the spectrum scarcity problem. The usable spectrum resources are almost entirely occupied, and thus, the increasing demands of radio access from IoT devices cannot be met. To tackle this problem, the Cognitive Internet of Things (CIoT) has been proposed. In a CIoT network, secondary users, i.e., sensors and actuators, can access the licensed spectrum bands provided by licensed primary users (such as cellular telephones). Security is a major concern in CIoT networks. However, the traditional encryption method at upper layers (such as symmetric and asymmetric ciphers) may not be suitable for CIoT networks since these networks are composed of low-profile devices. In this paper, we address the security issues in spectrum-leasing-based CIoT networks using physical layer methods. Considering that the CIoT networks are cooperative in nature, we propose to employ cooperative jamming to achieve secure transmission. In our proposed cooperative jamming scheme, a certain secondary user is employed as the helper to harvest energy transmitted by the source and then uses the harvested energy to generate an artificial noise that jams the eavesdropper without interfering with the legitimate receivers. The goal is to minimize the Signal to Interference plus Noise Ratio (SINR) at the eavesdropper subject to the Quality of Service (QoS) constraints of the primary traffic and the secondary traffic. We formulate the minimization problem into a two-stage robust optimization problem based on the worst-case Channel State Information of the Eavesdropper (ECSI). By using Semi-Definite Programming (SDP), the optimal solutions of the transmit covariance matrices can be obtained. Moreover, in order to build an incentive mechanism for the secondary users, we propose an auction framework based on the cooperative

  7. Worst-Case Cooperative Jamming for Secure Communications in CIoT Networks.

    PubMed

    Li, Zhen; Jing, Tao; Ma, Liran; Huo, Yan; Qian, Jin

    2016-03-07

    The Internet of Things (IoT) is a significant branch of the ongoing advances in the Internet and mobile communications. The use of a large number of IoT devices makes the spectrum scarcity problem even more serious. The usable spectrum resources are almost entirely occupied, and thus, the increasing radio access demands of IoT devices cannot be met. To tackle this problem, the Cognitive Internet of Things (CIoT) has been proposed. In a CIoT network, secondary users, i.e., sensors and actuators, can access the licensed spectrum bands provided by licensed primary users (such as telephones). Security is a major concern in CIoT networks. However, the traditional encryption method at upper layers (such as symmetric cryptography and asymmetric cryptography) may be compromised in CIoT networks, since these types of networks are heterogeneous. In this paper, we address the security issue in spectrum-leasing-based CIoT networks using physical layer methods. Considering that the CIoT networks are cooperative networks, we propose to employ cooperative jamming to achieve secrecy transmission. In the cooperative jamming scheme, a certain secondary user is employed as the helper to harvest energy transmitted by the source and then uses the harvested energy to generate an artificial noise that jams the eavesdropper without interfering with the legitimate receivers. The goal is to minimize the signal to interference plus noise ratio (SINR) at the eavesdropper subject to the quality of service (QoS) constraints of the primary traffic and the secondary traffic. We formulate the considered minimization problem into a two-stage robust optimization problem based on the worst-case Channel State Information of the Eavesdropper. By using semi-definite programming (SDP), the optimal solutions of the transmit covariance matrices can be obtained. Moreover, in order to build an incentive mechanism for the secondary users, we propose an auction framework based on the cooperative jamming scheme

  8. Interplanetary crew dose estimates for worst case solar particle events based on historical data for the Carrington flare of 1859.

    PubMed

    Stephens, Daniel L; Townsend, Lawrence W; Hoff, Jennifer L

    2005-01-01

    Over the past two decades, hypothetical models of "worst-case" solar particle event (SPE) spectra have been proposed in order to place an upper bound on radiation doses to critical body organs of interplanetary crews on deep space missions. These event spectra are usually formulated using hypothetical extrapolations of space measurements for previous large events. Here we take a different approach. Recently reported analyses of ice core samples indicate that the Carrington flare of 1859 is the largest event observed in the past 500 years. These ice core data yield estimates of the proton fluence for energies greater than 30 MeV, but provide no other spectrum information. Assuming that the proton energy distribution for such an event is similar to that measured for other recent, large events, interplanetary crew doses are estimated for these hypothetical worst case SPE spectra. These estimated doses are life threatening unless substantial shielding is provided.

  9. Space Environment Effects: Model for Emission of Solar Protons (ESP)--Cumulative and Worst-Case Event Fluences

    NASA Technical Reports Server (NTRS)

    Xapsos, M. A.; Barth, J. L.; Stassinopoulos, E. G.; Burke, Edward A.; Gee, G. B.

    1999-01-01

    The effects that solar proton events have on microelectronics and solar arrays are important considerations for spacecraft in geostationary and polar orbits and for interplanetary missions. Designers of spacecraft and mission planners are required to assess the performance of microelectronic systems under a variety of conditions. A number of useful approaches exist for predicting information about solar proton event fluences and, to a lesser extent, peak fluxes. This includes the cumulative fluence over the course of a mission, the fluence of a worst-case event during a mission, the frequency distribution of event fluences, and the frequency distribution of large peak fluxes. Naval Research Laboratory (NRL) and NASA Goddard Space Flight Center, under the sponsorship of NASA's Space Environments and Effects (SEE) Program, have developed a new model for predicting cumulative solar proton fluences and worst-case solar proton events as functions of mission duration and user confidence level. This model is called the Emission of Solar Protons (ESP) model.

  10. Chebyshev-polynomial-based (CPB) unified model neural network for the worst-case identification of nonlinear systems H∞ problem

    NASA Astrophysics Data System (ADS)

    Jeng, Jin-Tsong; Lee, Tsu-Tian

    1998-03-01

    In this paper, we propose a neural network model with a faster learning speed and a good approximate capability in the function approximation for solving worst-case identification of nonlinear systems H(infinity ) problems. Specifically, via the approximate transformable technique, we develop a Chebyshev Polynomials Based unified model neural network for solving the worst-case identification of nonlinear systems H(infinity ) problems. Based on this approximate transformable technique, the relationship between the single-layered neural network and multi-layered perceptron neural network is derived. It is shown that the Chebyshev Polynomials Based unified model neural network can be represented as a functional link network that is based on Chebyshev polynomials. We also derive a new learning algorithm such that the infinity norm of the transfer function from the input to the output is under a prescribed level. It turns out that the Chebyshev Polynomials Based unified model neural network not only has the same capability of universal approximator, but also has a faster learning speed than multi-layered perceptron or the recurrent neural network in the deterministic worst-case identification of nonlinear systems H(infinity ) problems.

  11. Control-oriented modelization of a satellite with large flexible appendages and use of worst-case analysis to verify robustness to model uncertainties of attitude control

    NASA Astrophysics Data System (ADS)

    Gasbarri, Paolo; Monti, Riccardo; Campolo, Giovanni; Toglia, Chiara

    2012-12-01

    lengthy and expensive: difficulty and cost do increase because of the overall system dimension that depends on the number of uncertainties. Uncertain parameters have to be parametrically investigated to determine robust performance of the control laws via gridding approaches. In particular in this paper we propose to consider two methods: (i) a conventional Monte Carlo analysis, and (ii) a worst-case analysis, i.e., an optimization process to find an estimation of the true worst-case behaviour. Both techniques allow to verify that the design is robust enough to meet the system performance specification in case of uncertainties.

  12. Probabilistic risk assessment for the Los Alamos Meson Physics Facility worst-case design-basis accident

    SciTech Connect

    Sharirli, M.; Butner, J.M.; Rand, J.L.; Macek, R.J. ); McKinney, S.J. ); Roush, M.L. . Center for Reliability Engineering)

    1992-01-01

    This paper presents results from a Los Alamos National Laboratory Engineering and Safety Analysis Group assessment of the worse-case design-basis accident associated with the Clinton P. Anderson Meson Physics Facility (LAMPF)/Weapons Neutron Research (WNR) Facility. The primary goal of the analysis was to quantify the accident sequences that result in personnel radiation exposure in the WNR Experimental Hall following the worst-case design-basis accident, a complete spill of the LAMPF accelerator 1L beam. This study also provides information regarding the roles of hardware systems and operators in these sequences, and insights regarding the areas where improvements can increase facility-operation safety. Results also include confidence ranges to incorporate combined effects of uncertainties in probability estimates and importance measures to determine how variations in individual events affect the frequencies in accident sequences.

  13. Probabilistic risk assessment for the Los Alamos Meson Physics Facility worst-case design-basis accident

    SciTech Connect

    Sharirli, M.; Butner, J.M.; Rand, J.L.; Macek, R.J.; McKinney, S.J.; Roush, M.L.

    1992-12-01

    This paper presents results from a Los Alamos National Laboratory Engineering and Safety Analysis Group assessment of the worse-case design-basis accident associated with the Clinton P. Anderson Meson Physics Facility (LAMPF)/Weapons Neutron Research (WNR) Facility. The primary goal of the analysis was to quantify the accident sequences that result in personnel radiation exposure in the WNR Experimental Hall following the worst-case design-basis accident, a complete spill of the LAMPF accelerator 1L beam. This study also provides information regarding the roles of hardware systems and operators in these sequences, and insights regarding the areas where improvements can increase facility-operation safety. Results also include confidence ranges to incorporate combined effects of uncertainties in probability estimates and importance measures to determine how variations in individual events affect the frequencies in accident sequences.

  14. In situ monitoring of soil dissolution dynamics: a rapid and simple method for determining worst-case soils for cleaning validation.

    PubMed

    Sharnez, Rizwan; Lathia, Justin; Kahlenberg, David; Prabhu, Sunil; Dekleva, Michael

    2004-01-01

    A common approach utilized in validating the cleaning of multi-product equipment is to challenge the cleaning cycle with the hardest-to-clean, or "worst-case", soil. The worst-case soil is often determined through bench-scale experiments. These experiments can be tricky and time-consuming, especially when the dissolution dynamics of the soils are characterized by crossovers beyond the limit of visual detection. This paper describes a simple in situ method for monitoring soil dissolution dynamics and rapidly determining worst-case soils for cleaning validation. The method utilizes the real-time response of electrical conductivity to identify crossovers and to determine the optimal time for endpoint analysis. The results address the sensitivity and reproducibility of the method and the identification of critical experimental parameters. The dissolution dynamics of several parenteral products are compared.

  15. Conceptual modeling for identification of worst case conditions in environmental risk assessment of nanomaterials using nZVI and C60 as case studies.

    PubMed

    Grieger, Khara D; Hansen, Steffen F; Sørensen, Peter B; Baun, Anders

    2011-09-01

    Conducting environmental risk assessment of engineered nanomaterials has been an extremely challenging endeavor thus far. Moreover, recent findings from the nano-risk scientific community indicate that it is unlikely that many of these challenges will be easily resolved in the near future, especially given the vast variety and complexity of nanomaterials and their applications. As an approach to help optimize environmental risk assessments of nanomaterials, we apply the Worst-Case Definition (WCD) model to identify best estimates for worst-case conditions of environmental risks of two case studies which use engineered nanoparticles, namely nZVI in soil and groundwater remediation and C(60) in an engine oil lubricant. Results generated from this analysis may ultimately help prioritize research areas for environmental risk assessments of nZVI and C(60) in these applications as well as demonstrate the use of worst-case conditions to optimize future research efforts for other nanomaterials. Through the application of the WCD model, we find that the most probable worst-case conditions for both case studies include i) active uptake mechanisms, ii) accumulation in organisms, iii) ecotoxicological response mechanisms such as reactive oxygen species (ROS) production and cell membrane damage or disruption, iv) surface properties of nZVI and C(60), and v) acute exposure tolerance of organisms. Additional estimates of worst-case conditions for C(60) also include the physical location of C(60) in the environment from surface run-off, cellular exposure routes for heterotrophic organisms, and the presence of light to amplify adverse effects. Based on results of this analysis, we recommend the prioritization of research for the selected applications within the following areas: organism active uptake ability of nZVI and C(60) and ecotoxicological response end-points and response mechanisms including ROS production and cell membrane damage, full nanomaterial characterization taking

  16. 41 CFR 102-80.150 - What is meant by “reasonable worst case fire scenario”?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... quantitative analysis of the probability of occurrence of each scenario and combination of events will be...., furniture, trash, paper, chemicals), potential fire ignition locations (e.g., bedroom, office,...

  17. 41 CFR 102-80.150 - What is meant by “reasonable worst case fire scenario”?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... quantitative analysis of the probability of occurrence of each scenario and combination of events will be...., furniture, trash, paper, chemicals), potential fire ignition locations (e.g., bedroom, office,...

  18. 41 CFR 102-80.150 - What is meant by “reasonable worst case fire scenario”?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... quantitative analysis of the probability of occurrence of each scenario and combination of events will be...., furniture, trash, paper, chemicals), potential fire ignition locations (e.g., bedroom, office,...

  19. Worst-Case GPS Scintillations on the Ground Estimated from Radio Occultation Observations of FORMOSAT-3/COSMIC During 2007-2014

    NASA Astrophysics Data System (ADS)

    Liu, J. Y.; Chen, S. P.; Yeh, W. H.; Tsai, H. F.; Rajesh, P. K.

    2016-07-01

    The FORMOSAT-3/COSMIC (F3/C) satellite probes the S4 scintillation index profile of GPS signals by using the radio occultation (RO) technique. In this study, for practical use on the Earth's surface, a method is developed to convert and integrate the probed RO S4 index, so obtaining the scintillation on the ground. To estimate the worst case, the maximum value on each profile probed by F3/C, which is termed S4max, is isolated. The isolated data are further used to construct the global three-dimensional distributions of S4max for various local times, seasons, solar activities, and locations. The converted S4max for the first time estimates the global distribution of ionospheric scintillations in the GPS L1 band C/A code signal on the ground. The results show that the worst-case scintillations appear within the low-latitude region of ±30°N, peaking around ±20°N magnetic latitude; they begin at 1900 MLT, reach their maximum at 2100 MLT, and vanish by about 0200-0300 MLT. The most pronounced low-latitude scintillation occurs over the South American and African sectors.

  20. Performance of a normalized energy metric without jammer state information for an FH/MFSK system in worst case partial band jamming

    NASA Technical Reports Server (NTRS)

    Lee, P. J.

    1985-01-01

    For a frequency-hopped noncoherent MFSK communication system without jammer state information (JSI) in a worst case partial band jamming environment, it is well known that the use of a conventional unquantized metric results in very poor performance. In this paper, a 'normalized' unquantized energy metric is suggested for such a system. It is shown that with this metric, one can save 2-3 dB in required signal energy over the system with hard decision metric without JSI for the same desired performance. When this very robust metric is compared to the conventional unquantized energy metric with JSI, the loss in required signal energy is shown to be small. Thus, the use of this normalized metric provides performance comparable to systems for which JSI is known. Cutoff rate and bit error rate with dual-k coding are used for the performance measures.

  1. Acute Exposure to Worst-Case Concentrations of Amitraz Does Not Affect Honey Bee Learning, Short-Term Memory, or Hemolymph Octopamine Levels.

    PubMed

    Rix, Rachel R; Christopher Cutler, G

    2016-12-27

    Amitraz, an acaricide used to treat Varroa destructor Anderson & Trueman, is one of the most commonly detected pesticides in honey bee (Apis mellifera L.) hives. Acaricides sometimes negatively impact honey bee cognition, but potential effects of amitraz on honey bee learning have been rarely studied. We topically exposed foragers to 95th percentile field-relevant levels of amitraz and, 24 h later, tested the ability of bees to associate a sucrose reward with a conditioned odor (learning response) using the proboscis extension response (PER). We then tested the ability of the bees to retain this memory 1 h and 2 h post-conditioning. Because amitraz is thought to affect octopamine metabolism in honey bees, and because octopamine is directly related to honey bee learning and memory, we also examined effects of exposure to amitraz on octopamine levels in honey bee hemolymph. We found that acute exposure to 95th percentile doses of amitraz had no impact on honey bee learning or short-term memory as measured by PER. Concentrations of octopamine in hemolymph from our low amitraz treatment were 1.4-fold higher than control levels, but other treatments had no effect. Our results from worst-case acute exposure experiments with worker bees in the laboratory suggest that typical field-relevant (within hive) exposures to amitraz probably have little effect on honey bee learning and memory.

  2. Mission Scenario Development Workbench

    NASA Technical Reports Server (NTRS)

    Kordon, Mark; Baker, John; Gilbert, John; Hanks, David; Mandutianu, Dan; Hooper, David

    2006-01-01

    The Mission Scenario Development Workbench (MSDW) is a multidisciplinary performance analysis software tool for planning and optimizing space missions. It provides a number of new capabilities that are particularly useful for planning the surface activities on other planets. MSDW enables rapid planning of a space mission and supports flight system and scientific-instrumentation trades. It also provides an estimate of the ability of flight, ground, and science systems to meet high-level mission goals and provides means of evaluating expected mission performance at an early stage of planning in the project life cycle. In MSDW, activity plans and equipment-list spreadsheets are integrated with validated parameterized simulation models of spacecraft systems. In contrast to traditional approaches involving worst-case estimates with large margins, the approach embodied in MSDW affords more flexibility and more credible results early in the lifecycle through the use of validated, variable- fidelity models of spacecraft systems. MSDW is expected to help maximize the scientific return on investment for space missions by understanding early the performance required to have a successful mission while reducing the risk of costly design changes made at late stages in the project life cycle.

  3. Ethoprophos fate on soil-water interface and effects on non-target terrestrial and aquatic biota under Mediterranean crop-based scenarios.

    PubMed

    Leitão, Sara; Moreira-Santos, Matilde; Van den Brink, Paul J; Ribeiro, Rui; José Cerejeira, M; Sousa, José Paulo

    2014-05-01

    The present study aimed to assess the environmental fate of the insecticide and nematicide ethoprophos in the soil-water interface following the pesticide application in simulated maize and potato crops under Mediterranean agricultural conditions, particularly of irrigation. Focus was given to the soil-water transfer pathways (leaching and runoff), to the pesticide transport in soil between pesticide application (crop row) and non-application areas (between crop rows), as well as to toxic effects of the various matrices on terrestrial and aquatic biota. A semi-field methodology mimicking a "worst-case" ethoprophos application (twice the recommended dosage for maize and potato crops: 100% concentration v/v) in agricultural field situations was used, in order to mimic a possible misuse by the farmer under realistic conditions. A rainfall was simulated under a slope of 20° for both crop-based scenarios. Soil and water samples were collected for the analysis of pesticide residues. Ecotoxicity of soil and aquatic samples was assessed by performing lethal and sublethal bioassays with organisms from different trophic levels: the collembolan Folsomia candida, the earthworm Eisenia andrei and the cladoceran Daphnia magna. Although the majority of ethoprophos sorbed to the soil application area, pesticide concentrations were detected in all water matrices illustrating pesticide transfer pathways of water contamination between environmental compartments. Leaching to groundwater proved to be an important transfer pathway of ethoprophos under both crop-based scenarios, as it resulted in high pesticide concentration in leachates from Maize (130µgL(-1)) and Potato (630µgL(-1)) crop scenarios, respectively. Ethoprophos application at the Potato crop scenario caused more toxic effects on terrestrial and aquatic biota than at the Maize scenario at the recommended dosage and lower concentrations. In both crop-based scenarios, ethoprophos moved with the irrigation water flow to the

  4. Worldwide variations in the lifetime probability of reproductive cancer in women: implications of best-case, worst-case, and likely-case assumptions about the effect of oral contraceptive use.

    PubMed

    Petitti, D B; Porterfield, D

    1992-02-01

    Cancer incidence in countries representative of three patterns of reproductive cancer and age-specific mortality was used to estimate the effect of oral contraceptive use on the lifetime probability of reproductive cancer under three sets of assumptions about the effects of oral contraceptives. Under the set of assumptions considered likely, oral contraceptives were estimated to reduce or increase only slightly the lifetime probability of any reproductive cancer in each setting. Under worst-case assumptions, oral contraceptives were estimated to increase the lifetime probability of reproductive cancer only modestly in settings with low cancer rates and in settings with high rates of breast, ovarian, and endometrial cancer, but it might have a large impact on lifetime probability of reproductive cancer in settings with high cervical cancer rates. Under best-case assumptions, oral contraceptives were estimated to decrease the lifetime probability of reproductive cancer in each setting; this reduction was estimated to be greatest in settings where endometrial and ovarian cancer incidence are high.

  5. Dirofilariasis Mimicking an Acute Scrotum.

    PubMed

    Bertozzi, Mirko; Rinaldi, Victoria Elisa; Prestipino, Marco; Giovenali, Paolo; Appignani, Antonino

    2015-10-01

    Human infections caused by Dirofilaria repens have been reported in many areas of the world. We describe a case of a 3-year-old child with an intrascrotal mass caused by D repens mimicking an acute scrotum. This represents the first case of scrotal dirofilariasis described in pediatric age with such an unusual presentation.

  6. Xanthogranulomatous cholecystitis mimicking gallbladder cancer.

    PubMed

    Ewelukwa, Ofor; Ali, Omair; Akram, Salma

    2014-05-08

    Xanthogranulomatous cholecystitis (XGC) is a benign, uncommon variant of chronic cholecystitis characterised by focal or diffuse destructive inflammatory process of the gallbladder (GB). Macroscopically, it appears like yellowish tumour-like masses in the wall of the GB. This article reports on a 74-year-old woman with XGC mimicking GB cancer.

  7. Missed Appendicitis: Mimicking Urologic Symptoms

    PubMed Central

    Akhavizadegan, Hamed

    2012-01-01

    Appendicitis, a common disease, has different presentations. This has made its diagnosis difficult. This paper aims to present two cases of missed appendicitis with completely urologic presentation and the way that helped us to reach the correct diagnosis. The first case with symptoms fully related to kidney and the second mimicking epididymorchitis hindered prompt diagnosis. Right site of the pain, relapsing fever, frequent physical examination, and resistance to medical treatment were main clues which help us to make correct diagnosis. PMID:23326748

  8. Norwegian scabies mimicking rupioid psoriasis*

    PubMed Central

    Costa, Juliana Bastos; de Sousa, Virna Lygia Lobo Rocha; da Trindade Neto, Pedro Bezerra; Paulo Filho, Thomás de Aquino; Cabral, Virgínia Célia Dias Florêncio; Pinheiro, Patrícia Moura Rossiter

    2012-01-01

    Norwegian scabies is a highly contagious skin infestation caused by an ectoparasite, Scarcoptes scabiei var. Hominis, which mainly affects immunosuppressed individuals. Clinically, it may simulate various dermatoses such as psoriasis, Darier's disease, seborrheic dermatitis, among others. This is a case report of a 33-year-old woman, immunocompetent, diagnosed with generalized anxiety disorder (cancer phobia), who had erythematous, well-defined plaques, covered with rupioid crusts, on her neck, axillary folds, breast, periumbilical region, groin area, besides upper back and elbows, mimicking an extremely rare variant of psoriasis, denominated rupioid psoriasis. PMID:23197214

  9. Megakaryocytes mimicking metastatic breast carcinoma.

    PubMed

    Hoda, Syed A; Resetkova, Erika; Yusuf, Yasmin; Cahan, Anthony; Rosen, Paul P

    2002-05-01

    False-positive diagnosis of lymph nodes occurs when a benign element in a lymph node, or in its capsule, is interpreted as metastatic carcinoma. This report describes a patient with breast carcinoma who had megakaryocytes in axillary sentinel lymph nodes mimicking metastatic carcinoma. The patient had no history of a hematologic disease, and we found no evidence of a concurrent hematopoietic disorder. The megakaryocytes were reactive for CD31, CD61, and von Willebrand factor, but not for cytokeratin (AE1/AE3). Megakaryocytes should be added to the list of benign histologic abnormalities that may simulate metastatic carcinoma in a sentinel lymph node.

  10. The great mimickers of rosacea.

    PubMed

    Olazagasti, Jeannette; Lynch, Peter; Fazel, Nasim

    2014-07-01

    Although rosacea is one of the most common conditions treated by dermatologists, it also is one of the most misunderstood. It is a chronic disorder affecting the central parts of the face and is characterized by frequent flushing; persistent erythema (ie, lasting for at least 3 months); telangiectasia; and interspersed episodes of inflammation with swelling, papules, and pustules. Understanding the clinical variants and disease course of rosacea is important to differentiate this entity from other conditions that can mimic rosacea. Herein we present several mimickers of rosacea that physicians should consider when diagnosing this condition.

  11. Challenging mimickers of primary systemic vasculitis.

    PubMed

    Miloslavsky, Eli M; Stone, John H; Unizony, Sebastian H

    2015-01-01

    The need to distinguish true primary systemic vasculitis from its multiple potential mimickers is one of the most challenging diagnostic conundrums in clinical medicine. This article reviews 9 challenging vasculitis mimickers: fibromuscular dysplasia, calciphylaxis, segmental arterial mediolysis, antiphospholipid syndrome, hypereosinophilic syndrome, lymphomatoid granulomatosis, malignant atrophic papulosis, livedoid vasculopathy, and immunoglobulin G4-related disease.

  12. Inverse heat mimicking of given objects

    NASA Astrophysics Data System (ADS)

    Alwakil, Ahmed; Zerrad, Myriam; Bellieud, Michel; Amra, Claude

    2017-03-01

    We address a general inverse mimicking problem in heat conduction. The objects to cloak and mimic are chosen beforehand; these objects identify a specific set of space transformations. The shapes that can be mimicked are derived from the conductivity matrices. Numerical calculation confirms all of the analytical predictions. The technique provides key advantages for applications and can be extended to the field of waves.

  13. Black hole mimickers: Regular versus singular behavior

    SciTech Connect

    Lemos, Jose P. S.; Zaslavskii, Oleg B.

    2008-07-15

    Black hole mimickers are possible alternatives to black holes; they would look observationally almost like black holes but would have no horizon. The properties in the near-horizon region where gravity is strong can be quite different for both types of objects, but at infinity it could be difficult to discern black holes from their mimickers. To disentangle this possible confusion, we examine the near-horizon properties, and their connection with far away asymptotic properties, of some candidates to black mimickers. We study spherically symmetric uncharged or charged but nonextremal objects, as well as spherically symmetric charged extremal objects. Within the uncharged or charged but nonextremal black hole mimickers, we study nonextremal {epsilon}-wormholes on the threshold of the formation of an event horizon, of which a subclass are called black foils, and gravastars. Within the charged extremal black hole mimickers we study extremal {epsilon}-wormholes on the threshold of the formation of an event horizon, quasi-black holes, and wormholes on the basis of quasi-black holes from Bonnor stars. We elucidate whether or not the objects belonging to these two classes remain regular in the near-horizon limit. The requirement of full regularity, i.e., finite curvature and absence of naked behavior, up to an arbitrary neighborhood of the gravitational radius of the object enables one to rule out potential mimickers in most of the cases. A list ranking the best black hole mimickers up to the worst, both nonextremal and extremal, is as follows: wormholes on the basis of extremal black holes or on the basis of quasi-black holes, quasi-black holes, wormholes on the basis of nonextremal black holes (black foils), and gravastars. Since in observational astrophysics it is difficult to find extremal configurations (the best mimickers in the ranking), whereas nonextremal configurations are really bad mimickers, the task of distinguishing black holes from their mimickers seems to

  14. Bone tumor mimickers: A pictorial essay

    PubMed Central

    Mhuircheartaigh, Jennifer Ni; Lin, Yu-Ching; Wu, Jim S

    2014-01-01

    Focal lesions in bone are very common and many of these lesions are not bone tumors. These bone tumor mimickers can include numerous normal anatomic variants and non-neoplastic processes. Many of these tumor mimickers can be left alone, while others can be due to a significant disease process. It is important for the radiologist and clinician to be aware of these bone tumor mimickers and understand the characteristic features which allow discrimination between them and true neoplasms in order to avoid unnecessary additional workup. Knowing which lesions to leave alone or which ones require workup can prevent misdiagnosis and reduce patient anxiety. PMID:25114385

  15. 49 CFR 194.105 - Worst case discharge.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... estimate), multiplied by the maximum flow rate expressed in barrels per hour (based on the maximum daily... battery of tanks within a single secondary containment system, adjusted for the capacity or size of...

  16. 49 CFR 194.105 - Worst case discharge.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... estimate), multiplied by the maximum flow rate expressed in barrels per hour (based on the maximum daily... battery of tanks within a single secondary containment system, adjusted for the capacity or size of...

  17. 49 CFR 194.105 - Worst case discharge.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...: Prevention measure Standard Credit(percent) Secondary containment >100% NFPA 30 50 Built/repaired to API standards API STD 620/650/653 10 Overfill protection standards API RP 2350 5 Testing/cathodic protection API STD 650/651/653 5 Tertiary containment/drainage/treatment NFPA 30 5 Maximum allowable credit 75...

  18. 33 CFR 154.1029 - Worst case discharge.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... vessel regardless of the presence of secondary containment; plus (2) The discharge from all piping... historic discharge data or the best estimate in the absence of historic discharge data for the...

  19. 49 CFR 194.105 - Worst case discharge.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... hours (based on historic discharge data or in the absence of such historic data, the operator's best... battery of tanks within a single secondary containment system, adjusted for the capacity or size of the secondary containment system, expressed in barrels (cubic meters). (4) Operators may claim...

  20. Developing ecological scenarios for the prospective aquatic risk assessment of pesticides.

    PubMed

    Rico, Andreu; Van den Brink, Paul J; Gylstra, Ronald; Focks, Andreas; Brock, Theo Cm

    2016-07-01

    The prospective aquatic environmental risk assessment (ERA) of pesticides is generally based on the comparison of predicted environmental concentrations in edge-of-field surface waters with regulatory acceptable concentrations derived from laboratory and/or model ecosystem experiments with aquatic organisms. New improvements in mechanistic effect modeling have allowed a better characterization of the ecological risks of pesticides through the incorporation of biological trait information and landscape parameters to assess individual, population and/or community-level effects and recovery. Similarly to exposure models, ecological models require scenarios that describe the environmental context in which they are applied. In this article, we propose a conceptual framework for the development of ecological scenarios that, when merged with exposure scenarios, will constitute environmental scenarios for prospective aquatic ERA. These "unified" environmental scenarios are defined as the combination of the biotic and abiotic parameters that are required to characterize exposure, (direct and indirect) effects, and recovery of aquatic nontarget species under realistic worst-case conditions. Ideally, environmental scenarios aim to avoid a potential mismatch between the parameter values and the spatial-temporal scales currently used in aquatic exposure and effect modeling. This requires a deeper understanding of the ecological entities we intend to protect, which can be preliminarily addressed by the formulation of ecological scenarios. In this article we present a methodological approach for the development of ecological scenarios and illustrate this approach by a case-study for Dutch agricultural ditches and the example focal species Sialis lutaria. Finally, we discuss the applicability of ecological scenarios in ERA and propose research needs and recommendations for their development and integration with exposure scenarios. Integr Environ Assess Manag 2016;12:510-521.

  1. Scenarios of large mammal loss in Europe for the 21st century.

    PubMed

    Rondinini, Carlo; Visconti, Piero

    2015-08-01

    Distributions and populations of large mammals are declining globally, leading to an increase in their extinction risk. We forecasted the distribution of extant European large mammals (17 carnivores and 10 ungulates) based on 2 Rio+20 scenarios of socioeconomic development: business as usual and reduced impact through changes in human consumption of natural resources. These scenarios are linked to scenarios of land-use change and climate change through the spatial allocation of land conversion up to 2050. We used a hierarchical framework to forecast the extent and distribution of mammal habitat based on species' habitat preferences (as described in the International Union for Conservation of Nature Red List database) within a suitable climatic space fitted to the species' current geographic range. We analyzed the geographic and taxonomic variation of habitat loss for large mammals and the potential effect of the reduced impact policy on loss mitigation. Averaging across scenarios, European large mammals were predicted to lose 10% of their habitat by 2050 (25% in the worst-case scenario). Predicted loss was much higher for species in northwestern Europe, where habitat is expected to be lost due to climate and land-use change. Change in human consumption patterns was predicted to substantially improve the conservation of habitat for European large mammals, but not enough to reduce extinction risk if species cannot adapt locally to climate change or disperse.

  2. Tracheobronchial Amyloidosis Mimicking Tracheal Tumor.

    PubMed

    Tanrıverdi, Elif; Özgül, Mehmet Akif; Uzun, Oğuz; Gül, Şule; Çörtük, Mustafa; Yaşar, Zehra; Acat, Murat; Arda, Naciye; Çetinkaya, Erdoğan

    2016-01-01

    Tracheobronchial amyloidosis is a rare presentation and accounts for about 1% of benign tumors in this area. The diagnosis of disease is delayed due to nonspecific pulmonary symptoms. Therapeutic approaches are required to control progressive pulmonary symptoms for most of the patients. Herein, we report a case of a 68-year-old man admitted with progressive dyspnea to our institution for further evaluation and management. He was initially diagnosed with and underwent management for bronchial asthma for two years but had persistent symptoms despite optimal medical therapy. Pulmonary computed tomography scan revealed severe endotracheal stenosis. Bronchoscopy was performed and showed endotracheal mass obstructing 70% of the distal trachea and mimicking a neoplastic lesion. The mass was successfully resected by mechanical resection, argon plasma coagulation (APC), and Nd-YAG laser during rigid bronchoscopy. Biopsy materials showed deposits of amorphous material by hematoxylin and eosin staining and these deposits were selectively stained with Congo Red. Although this is a rare clinical condition, this case indicated that carrying out a bronchoscopy in any patient complaining of atypical bronchial symptoms or with uncontrolled asthma is very important.

  3. Tracheobronchial Amyloidosis Mimicking Tracheal Tumor

    PubMed Central

    Özgül, Mehmet Akif; Uzun, Oğuz; Yaşar, Zehra; Acat, Murat; Arda, Naciye; Çetinkaya, Erdoğan

    2016-01-01

    Tracheobronchial amyloidosis is a rare presentation and accounts for about 1% of benign tumors in this area. The diagnosis of disease is delayed due to nonspecific pulmonary symptoms. Therapeutic approaches are required to control progressive pulmonary symptoms for most of the patients. Herein, we report a case of a 68-year-old man admitted with progressive dyspnea to our institution for further evaluation and management. He was initially diagnosed with and underwent management for bronchial asthma for two years but had persistent symptoms despite optimal medical therapy. Pulmonary computed tomography scan revealed severe endotracheal stenosis. Bronchoscopy was performed and showed endotracheal mass obstructing 70% of the distal trachea and mimicking a neoplastic lesion. The mass was successfully resected by mechanical resection, argon plasma coagulation (APC), and Nd-YAG laser during rigid bronchoscopy. Biopsy materials showed deposits of amorphous material by hematoxylin and eosin staining and these deposits were selectively stained with Congo Red. Although this is a rare clinical condition, this case indicated that carrying out a bronchoscopy in any patient complaining of atypical bronchial symptoms or with uncontrolled asthma is very important. PMID:27594885

  4. Humanlike Robots - Synthetically Mimicking Humans

    NASA Technical Reports Server (NTRS)

    Bar-Cohen, Yoseph

    2012-01-01

    Nature inspired many inventions and the field of technology that is based on the mimicking or inspiration of nature is widely known as Biomimetics and it is increasingly leading to many new capabilities. There are numerous examples of biomimetic successes including the copying of fins for swimming, and the inspiration of the insects and birds flight. More and more commercial implementations of biomimetics are appearing and behaving lifelike and applications are emerging that are important to our daily life. Making humanlike robots is the ultimate challenge to biomimetics and, for many years, it was considered science fiction, but such robots are becoming an engineering reality. Advances in producing such robot are allowing them to perform impressive functions and tasks. The development of such robots involves addressing many challenges and is raising concerns that are related to fear of their application implications and potential ethical issues. In this paper, the state-of-the-art of humanlike robots, potential applications and challenges will be reviewed.

  5. Fibrosing mediastinitis mimicking bronchogenic carcinoma

    PubMed Central

    Bayiz, Hulya; Mutluay, Neslihan; Koyuncu, Adem; Demirag, Funda; Dagli, Gulfidan; Berktas, Bahadir; Berkoglu, Mine

    2013-01-01

    Fibrosing mediastinitis is a rare but benign disorder characterized by an excessive fibrotic reaction in the mediastinum which can result in compromise of airways, great vessels, and other mediastinal structures. In this paper we presented a patient with fibrosing mediastinitis mimicking bronchogenic carcinoma. The patient was a 32-year-old diabetic male admitting with cough and hemoptysis. There was a right hilar mass and multiple mediastinal conglomerated lymph nodes on chest computed tomography. Positron emission tomography with computed tomography (PET/CT) scan demonstrated increased fluorodeoxyglucose (FDG) uptake at the right hilar mass lesion and mediastinal lymph nodes. Fiberoptic bronchoscopy showed mucosal distortion of right upper lobe. Pathologic examination of the mucosal biopsy revealed inflammation. Endobronchial ultrasound guided transbronchial needle and cervical mediastinoscopic lymph node biopsies were undiagnostic. Diagnostic thoracotomy confirmed the diagnosis fibrosing mediastinitis. Administration of six months of systemic corticosteroid and antituberculous therapy was not beneficial. In conclusion, despite being a rare clinical entity, fibrosing mediastinitis should be kept in mind in the differential diagnosis of mediastinal mass lesions of unknown etiology. The diagnosis is exceptionally difficult in the presence of atypical radiological findings. The treatment is particularly challenging without any proven effective therapy. PMID:23372962

  6. Inverse heat mimicking of given objects

    PubMed Central

    Alwakil, Ahmed; Zerrad, Myriam; Bellieud, Michel; Amra, Claude

    2017-01-01

    We address a general inverse mimicking problem in heat conduction. The objects to cloak and mimic are chosen beforehand; these objects identify a specific set of space transformations. The shapes that can be mimicked are derived from the conductivity matrices. Numerical calculation confirms all of the analytical predictions. The technique provides key advantages for applications and can be extended to the field of waves. PMID:28252031

  7. Simulation of X-38 Landing Scenarios With Landing Gear Failures

    NASA Technical Reports Server (NTRS)

    Fasanella, Edwin L.; Lyle, Karen H.; Pritchard, Jocelyn I.; Stockwell, Alan E.

    2000-01-01

    Abnormal landing scenarios of the X-38 prototype Crew Rescue Vehicle (CRV) were modeled for three different cases involving non-deployment of landing gear with an explicit dynamic nonlinear finite element code, MSC/DYTRAN. The goal of this research was to develop models to predict the probability of crew injuries. The initial velocity conditions for the X-38 with chute deployed were 10 ft/s vertical and 57 ft/s longitudinal velocity. An MSC/NASTRAN structural model was supplied by JSC and was converted to a dynamic MSC/DYTRAN model. The MSC/NASTRAN model did not include seats or floor structure; thus, the acceleration of a lumped-mass attached to the bulkhead near each assumed occupant location was used to determine injury risk for each occupant. The worst case for injury was nondeployment of all gears. The mildest case was nondeployment of one main gear. Although a probability for minor injury was predicted for all cases, it is expected that the addition of energy-absorbing floor structure and seats would greatly diminish the probability of injury.

  8. Recurrent epiploic appendagitis mimicking appendicitis and cholecystitis

    PubMed Central

    Hearne, Christopher B.; Taboada, Jorge

    2017-01-01

    Epiploic appendagitis (EA) is a rare cause of acute abdominal pain caused by inflammation of an epiploic appendage. It has a nonspecific clinical presentation that may mimic other acute abdominal pathologies on physical exam, such as appendicitis, diverticulitis, or cholecystitis. However, EA is usually benign and self-limiting and can be treated conservatively. We present the case of a patient with two episodes of EA, the first mimicking acute appendicitis and the second mimicking acute cholecystitis. Although recurrence of EA is rare, it should be part of the differential diagnosis of acute, localized abdominal pain. A correct diagnosis of EA will prevent unnecessary hospitalization, antibiotic use, and surgical procedures. PMID:28127129

  9. Scenario-based radiation therapy margins for patient setup, organ motion, and particle range uncertainty

    NASA Astrophysics Data System (ADS)

    Bokrantz, Rasmus; Fredriksson, Albin

    2017-02-01

    This work extends and validates the scenario-based generalization of margins presented in Fredriksson and Bokrantz (2016 Phys. Med. Biol. 61 2067–82). Scenario-based margins are, in their original form, a method for robust planning under setup uncertainty where the sum of a plan evaluation criterion over a set of scenarios is optimized. The voxelwise penalties in the summands are weighted by a distribution of coefficients defined such that the method is mathematically equivalent to the use of conventional geometric margins if the scenario doses are calculated using the static dose cloud approximation. The purpose of this work is to extend scenario-based margins to general types of geometric uncertainty and to validate their use on clinical cases. Specifically, we outline how to incorporate density heterogeneity in the calculation of coefficients and demonstrate the extended method’s ability to safeguard against setup errors, organ motion, and range shifts (and combinations thereof). For a water phantom with a high-density slab partly covering the target, the extended form of scenario-based margins method led to improved target coverage robustness compared to the original method. At most minor differences in robustness were, however, observed between the extended and original method for a prostate and two lung patients, all treated with intensity-modulated proton therapy, yielding evidence that the calculation of weighting coefficients is generally insensitive to tissue heterogeneities. The scenario-based margins were, furthermore, verified to provide a comparable level of robustness to expected value and worst case optimization while circumventing some known shortcomings of these methods.

  10. Systemic sarcoidosis mimicking malignant metastatic disease

    PubMed Central

    Hammen, Irena; Sherson, David Lee; Davidsen, Jesper Roemhild

    2015-01-01

    We present a case of systemic sarcoidosis involving the liver, pancreas, lungs, mediastinal and intraabdominal lymph nodes and bones. Multiple organ system manifestations mimicked malignant metastatic disease. The diagnosis was established with clinical, radiological, and pathological findings after neoplasm was ruled out by pathological tests. The patient showed rapid symptom remission with systemic steroid treatment. PMID:26672956

  11. Lymphomatoid granulomatosis mimicking interstitial lung disease.

    PubMed

    Braham, Emna; Ayadi-Kaddour, Aïda; Smati, Belhassen; Ben Mrad, Sonia; Besbes, Mohammed; El Mezni, Faouzi

    2008-11-01

    Lymphoid granulomatosis is a rare form of pulmonary angiitis. This case report presents a patient with lymphoid granulomatosis in whom the clinical presentation, radiological features and the partial response to corticosteroid therapy mimicked interstitial lung disease. Lymphoid granulomatosis was only diagnosed at post-mortem examination. The range of reported clinical presentations, diagnostic approaches and outcomes are described.

  12. Topical report on release scenario analysis of long-term management of high-level defense waste at the Hanford Site

    SciTech Connect

    Wallace, R.W.; Landstrom, D.K.; Blair, S.C.; Howes, B.W.; Robkin, M.A.; Benson, G.L.; Reisenauer, A.E.; Walters, W.H.; Zimmerman, M.G.

    1980-11-01

    Potential release scenarios for the defense high-level waste (HLW) on the Hanford Site are presented. Presented in this report are the three components necessary for evaluating the various alternatives under consideration for long-term management of Hanford defense HLW: identification of scenarios and events which might directly or indirectly disrupt radionuclide containment barriers; geotransport calculations of waste migration through the site media; and consequence (dose) analyses based on groundwater and air pathways calculations. The scenarios described in this report provide the necessary parameters for radionuclide transport and consequence analysis. Scenarios are categorized as either bounding or nonbounding. Bounding scenarios consider worst case or what if situations where an actual and significant release of waste material to the environment would happen if the scenario were to occur. Bounding scenarios include both near-term and long-term scenarios. Near-term scenarios are events which occur at 100 years from 1990. Long term scenarios are potential events considered to occur at 1000 and 10,000 years from 1990. Nonbounding scenarios consider events which result in insignificant releases or no release at all to the environment. Three release mechanisms are described in this report: (1) direct exposure of waste to the biosphere by a defined sequence of events (scenario) such as human intrusion by drilling; (2) radionuclides contacting an unconfined aquifer through downward percolation of groundwater or a rising water table; and (3) cataclysmic or explosive release of radionuclides by such mechanisms as meteorite impact, fire and explosion, criticality, or seismic events. Scenarios in this report present ways in which these release mechanisms could occur at a waste management facility. The scenarios are applied to the two in-tank waste management alternatives: in-situ disposal and continued present action.

  13. Arctic Planning Scenarios: Scenario #2 - Safety and Security Scenario

    DTIC Science & Technology

    2011-07-01

    Narcotics are traded in bulk with cocaine & ecstasy going west and heroin going east; The US land border is now sealed behind a physical fence...nationale, 2011 Abstract …….. With the change in Northern climate over the past decade, current policy and media discussions have focused on...characterize legislation and policy on the Arctic, with a view to developing scenarios for future planning. This report presents one of two

  14. Scenario Based Approach for Multiple Source Tsunami Hazard Assessment for Sines, Portugal

    NASA Astrophysics Data System (ADS)

    Wronna, Martin; Omira, Rachid; Baptista, Maria Ana

    2015-04-01

    In this paper, we present a scenario-based approach for tsunami hazard assessment for the city and harbour of Sines, Portugal one the test-sites of project ASTARTE. Sines holds one of the most important deep-water ports which contains oil-bearing, petrochemical, liquid bulk, coal and container terminals. The port and its industrial infrastructures are facing the ocean to the southwest facing the main seismogenic sources. This work considers two different seismic zones: the Southwest Iberian Margin and the Gloria Fault. Within these two regions, a total of five scenarios were selected to assess tsunami impact at the test site. These scenarios correspond to the worst-case credible scenario approach based upon the largest events of the historical and paleo tsunami catalogues. The tsunami simulations from the source area towards the coast is carried out using NSWING a Non-linear Shallow Water Model With Nested Grids. The code solves the non-linear shallow water equations using the discretization and explicit leap-frog finite difference scheme, in a Cartesian or Spherical frame. The initial sea surface displacement is assumed to be equal to the sea bottom deformation that is computed by Okada equations. Both uniform and non-uniform slip conditions are used. The presented results correspond to the models using non-uniform slip conditions. In this study, the static effect of tides is analysed for three different tidal stages MLLW (mean lower low water) MSL (mean sea level) and MHHW (mean higher high water). For each scenario, inundation is described by maximum values of wave height, flow depth, drawdown, run-up and inundation distance. Synthetic waveforms are computed at virtual tide gages at specific locations outside and inside the harbour. The final results consist of Aggregate Scenario Maps presented for the different inundation parameters. This work is funded by ASTARTE - Assessment, Strategy And Risk Reduction for Tsunamis in Europe - FP7-ENV2013 6.4-3, Grant 603839

  15. Intramedullary cervical neurenteric cyst mimicking an abscess.

    PubMed

    Muzumdar, D; Bhatt, Y; Sheth, J

    2008-01-01

    We describe a cervical intramedullary neurenteric cyst in a 12-year-old male patient who presented with gradual onset and progressively worsening neck pain, spastic quadriparesis and impaired sensation in the C(2) dermatome. MR imaging revealed a well-defined peripherally enhancing cystic intramedullary lesion with a posteroinferior enhancing nodule at the C(2)-C(3) level mimicking an abscess. There was no evidence of spinal dysraphism. The lesion was completely resected through a posterior approach and the patient showed radical improvement in his symptomatology. At follow-up after 3 years, he was asymptomatic and the MR imaging showed no evidence of any residual or recurrent cyst. The case presented here is unique, since a spinal neurenteric cyst showing intense peripheral contrast enhancement mimicking an abscess is unusual. The radiological features, pathogenesis and surgical considerations in cervical intramedullary neurenteric cysts are discussed and the relevant literature is briefly reviewed.

  16. Spherical boson stars as black hole mimickers

    SciTech Connect

    Guzman, F. S.; Rueda-Becerril, J. M.

    2009-10-15

    We present spherically symmetric boson stars as black hole mimickers based on the power spectrum of a simple accretion disk model. The free parameters of the boson star are the mass of the boson and the fourth-order self-interaction coefficient in the scalar field potential. We show that even if the mass of the boson is the only free parameter, it is possible to find a configuration that mimics the power spectrum of the disk due to a black hole of the same mass. We also show that for each value of the self-interaction a single boson star configuration can mimic a black hole at very different astrophysical scales in terms of the mass of the object and the accretion rate. In order to show that it is possible to distinguish one of our mimickers from a black hole, we also study the deflection of light.

  17. Isolated giant molluscum contagiosum mimicking epidermoid cyst

    PubMed Central

    Uzuncakmak, Tugba K.; Kuru, Burce C.; Zemheri, Ebru I.; Zindanci, Ilkin; Turkoglu, Zafer; Kavala, Mukaddes

    2016-01-01

    Molluscum contagiosum is a benign cutaneous viral infection which is caused by double- stranded DNA poxvirus. It affects mainly children and young adults and usually presents with single or multiple umblicated papules or nodules on face, arms, legs and anogenital regions. It may present in atypical size and clinical appearance in patients with altered or impaired immunity and rarely in immuncompetent patients. Herein we present an immuncompetent young adult patient with isolated giant molluscum contagiosum, which was mimicking epidermoid cyst clinically. PMID:27648389

  18. A Pilocytic Astrocytoma Mimicking a Clinoidal Meningioma

    PubMed Central

    Hong, Christopher S.; Lehman, Norman L.; Sauvageau, Eric

    2014-01-01

    Pilocytic astrocytomas and meningiomas are benign, primary brain tumors that may involve the optic tract. Classically, the presence of a dural “tail” sign may differentiate a meningioma from other intracranial lesions. In this report, we describe a mass with the typical appearance of a clinoidal meningioma on magnetic resonance imaging (MRI) but postoperatively diagnosed as a pilocytic astrocytoma. This case illustrates the rare occurrence of a pilocytic astrocytoma mimicking a meningioma on MRI. PMID:24744944

  19. Mad honey intoxication mimicking acute coronary syndrome.

    PubMed

    Dur, Ali; Sonmez, Ertan; Civelek, Cemil; AhmetTurkdogan, Kenan; AkifVatankulu, Mehmet; Sogut, Ozgur

    2014-09-01

    Mad honey intoxication or grayanotoxin poisoning is caused by consumption of grayanotoxin-containing toxic honey produced from leaves and flowers of the Rhododendron family. Despite the rarity of intoxication cases, the correct diagnosis and treatment are required because of the significance of haemodynamic disturbance and confounding of symptoms for disease identification. We report herein a case of a patient with mad honey intoxication mimicking acute non-ST segment elevation myocardial infarction and review the pathophysiology and diagnostic considerations.

  20. Pulmonary diseases with imaging findings mimicking aspergilloma.

    PubMed

    Gazzoni, Fernando Ferreira; Severo, Luiz Carlos; Marchiori, Edson; Guimarães, Marcos Duarte; Garcia, Tiago Severo; Irion, Klaus L; Camargo, José Jesus; Felicetti, José Carlos; de Mattos Oliveira, Flavio; Hochhegger, Bruno

    2014-06-01

    Patients with preexisting lung cavities are at risk of developing intracavitary fungal colonization. Because Aspergillus spp. are the most commonly implicated fungi, these fungal masses are called aspergillomas. Their characteristic "ball-in-hole" appearance, however, may be found in a variety of other conditions that can produce radiologic findings mimicking aspergilloma. In this paper, we review the main diseases that may mimic the radiographic findings of aspergilloma, with brief descriptions of clinical, radiologic, and histopathologic findings.

  1. Rare Mimickers of Exostosis: A Case Series

    PubMed Central

    Perubhotla, Lakshmi Manasa

    2016-01-01

    Exophytic growths from bones are a common entity. Osteochondroma is the most common benign exophytic lesion and we tend to diagnose every benign looking exophytic lesion as osteochondroma. Here we reported two entities of cases, one was Nora’s lesion and another one was supracondylar process of humerus, both of which were mimickers of osteochondroma and their salient and differentiating features from osteochondromas. PMID:27630926

  2. Nuclear Security Futures Scenarios.

    SciTech Connect

    Keller, Elizabeth James Kistin; Warren, Drake Edward; Hayden, Nancy Kay; Passell, Howard D.; Malczynski, Leonard A.; Backus, George A.

    2017-01-01

    This report provides an overview of the scenarios used in strategic futures workshops conducted at Sandia on September 21 and 29, 2016. The workshops, designed and facilitated by analysts in Center 100, used scenarios to enable thought leaders to think collectively about the changing aspects of global nuclear security and the potential implications for the US Government and Sandia National Laboratories.

  3. Handheld X-ray Fluorescence Spectrometers: Radiation Exposure Risks of Matrix-Specific Measurement Scenarios.

    PubMed

    Rouillon, Marek; Kristensen, Louise J; Gore, Damian B

    2015-07-01

    This study investigates X-ray intensity and dispersion around handheld X-ray fluorescence (XRF) instruments during the measurement of a range of sample matrices to establish radiation exposure risk during operation. Four handheld XRF instruments representing three manufacturers were used on four smooth, flat-lying materials of contrasting matrix composition. Dose rates were measured at 10, 20, 30, and 40 cm intervals every 30° around the instrument at 0 and 45° from the horizontal, as well as vertically from the instrument screen. The analysis of polyethylene recorded dose rates 156 times higher (on average) than steel measurements and 34 times higher than both quartz sand and quartz sandstone. A worst-case exposure scenario was assumed where a user analyses a polyethylene material at arms reach for 1 h each working day for one year. This scenario resulted in an effective body dose of 73.5 μSv, equivalent to three to four chest X-rays (20 μSv) a year, 20 times lower than the average annual background radiation exposure in Australia and well below the annual exposure limit of 1 mSv for non-radiation workers. This study finds the advantages of using handheld XRF spectrometers far outweighs the risk of low radiation exposure linked to X-ray scattering from samples.

  4. Exposure scenarios for workers.

    PubMed

    Marquart, Hans; Northage, Christine; Money, Chris

    2007-12-01

    The new European chemicals legislation REACH (Registration, Evaluation, Authorisation and restriction of Chemicals) requires the development of Exposure Scenarios describing the conditions and risk management measures needed for the safe use of chemicals. Such Exposure Scenarios should integrate considerations of both human health and the environment. Specific aspects are relevant for worker exposure. Gathering information on the uses of the chemical is an important step in developing an Exposure Scenario. In-house information at manufacturers is an important source. Downstream users can contribute information through direct contact or through their associations. Relatively simple approaches (Tier 1 tools, such as the ECETOC Targeted Risk Assessment and the model EASE) can be used to develop broad Exposure Scenarios that cover many use situations. These approaches rely on the categorisation of just a few determinants, including only a small number of risk management measures. Such approaches have a limited discriminatory power and are rather conservative. When the hazard of the substance or the complexity of the exposure situation require a more in-depth approach, further development of the Exposure Scenarios with Tier 2 approaches is needed. Measured data sets of worker exposure are very valuable in a Tier 2 approach. Some downstream user associations have attempted to build Exposure Scenarios based on measured data sets. Generic Tier 2 tools for developing Exposure Scenarios do not exist yet. To enable efficient development of the worker exposure part of Exposure Scenarios a further development of Tier 1 and Tier 2 tools is needed. Special attention should be given to user friendliness and to the validity (boundaries) of the approaches. The development of standard worker exposure descriptions or full Exposure Scenarios by downstream user branches in cooperation with manufacturers and importers is recommended.

  5. Mars base buildup scenarios

    SciTech Connect

    Blacic, J.D.

    1985-01-01

    Two surface base build-up scenarios are presented in order to help visualize the mission and to serve as a basis for trade studies. In the first scenario, direct manned landings on the Martian surface occur early in the missions and scientific investigation is the main driver and rationale. In the second scenario, early development of an infrastructure to exploite the volatile resources of the Martian moons for economic purposes is emphasized. Scientific exploration of the surface is delayed at first, but once begun develops rapidly aided by the presence of a permanently manned orbital station.

  6. GLOBAL ALTERNATIVE FUTURE SCENARIOS

    EPA Science Inventory

    One way to examine possible future outcomes for environmental protection is through the development and analysis of alternative future scenarios. This type of assessment postulates two or more different paths that social and environmental development might take, using correspond...

  7. Emission scenarios: Explaining differences

    NASA Astrophysics Data System (ADS)

    Iyer, Gokul; Edmonds, James

    2017-01-01

    Carbon dioxide emission scenarios rely on a number of assumptions about how societies will develop in the future, creating uncertainty in projections. Now, research reveals the sensitivity of emission estimates to some of these assumptions.

  8. Nontuberculous mycobacterial pulmonary disease mimicking lung cancer

    PubMed Central

    Hong, Su Jin; Kim, Tae Jung; Lee, Jae-Ho; Park, Jeong-Soo

    2016-01-01

    Abstract To describe the features and clinical implications of computed tomography (CT), positron emission tomography (PET), and percutaneous needle aspiration biopsy (PCNB) in pulmonary nontuberculous mycobacterial (NTM) disease manifesting as a solitary nodule, mass, or mass-like consolidation mimicking malignancy. Among a cohort of 388 patients with NTM pulmonary disease, 14 patients with clinically and radiologically suspected lung cancer were included in our study. Two chest radiologists evaluated CT features, including lesion type (nodule, mass, or mass-like consolidation), morphologic features (margin, degree of enhancement, calcification), and presence of accompanying findings suggestive of NTM pulmonary disease (bronchiectasis with clustered centrilobular nodules or upper-lobe cavitary lesions) by consensus. Diagnostic procedures for microbiologic diagnosis of NTM disease and clinical outcome were reviewed. Incidence of NTM pulmonary disease presenting as solitary nodule/mass (n = 8) or mass-like consolidation (n = 6) was 3.6% (14 of 388). Most lesions were detected incidentally during routine health check-up or evaluation of other disease (11 of 14, 79%). Lesions typically showed poor contrast-enhancement (9 of 12) and internal calcification (6 of 14). No lesions had CT features suggestive of NTM pulmonary disease. All 4 lesions for which PET/CT imaging was performed showed strong fluorodeoxyglucose uptake simulating malignant lesions (mean, 4.9; range, 3.6–7.8). PCNB revealed mycobacterial histology in 6 of 11 specimens and positive culture results were obtained for 7 of 7 specimens. NTM pulmonary disease may present as a solitary nodule, mass, or mass-like consolidation mimicking malignancy. CT features and PCNB are important to diagnose NTM disease mimicking lung cancer to avoid unnecessary surgery. PMID:27367996

  9. Intradural Extramedullary Tuberculoma Mimicking En Plaque Meningioma

    PubMed Central

    Shim, Dae Moo; Kim, Tae Kyun; Chae, Soo Uk

    2010-01-01

    A 24-year-old man with tuberculosis meningitis developed acute paraplegia and sensory disturbances 5 weeks after receiving conventional antituberculous therapy. Magnetic resonance imaging revealed an intradural extramedullary long segmental mass mimicking en plaque meningioma at the T2-T6 vertebrae levels. Prompt surgical decompression was performed. A histology examination of the mass revealed a tuberculoma. After surgery, the patient showed improved motor power and a normal bladder function. Intradural extramedullary tuberculoma of the spinal cord is rare complication of tuberculosis meningitis, which can occur as a response to conventional antituberculous therapy. PMID:21119945

  10. Chondroblastoma of the acromion mimicking fibrous dysplasia.

    PubMed

    Gebert, Carsten; Hardes, Jendrik; Streitbürger, Arne; Vieth, Volker; Bürger, Horst; Winkelmann, Winfried; Gosheger, Georg

    2004-12-01

    The authors report the case of a 65-year-old man who presented with an expansive osteolytic lesion in the right acromion, mimicking cystic fibrous dysplasia. Magnetic resonance imaging showed a lesion with intermediate-signal intensity on T1-weighted images and a high-signal intensity on fat suppressed T2-weighted images. The biopsy led to the diagnosis of chondroblastoma. This tumour is rare in flat bones, and may mimic other benign or malignant lesions. It is therefore essential to perform a biopsy in order to obtain a definite diagnosis. The acromion was excised, and replaced with an iliac crest graft.

  11. Post-pancreatitis Fat Necrosis Mimicking Carcinomatosis.

    PubMed

    Smith, Joshua P; Arnoletti, J Pablo; Varadarajulu, Shyam; Morgan, Desiree E

    2008-01-01

    Acute pancreatitis can result in retroperitoneal fat necrosis, typically occurring in the peripancreatic region, with extension into the transverse mesocolon, omentum and mesenteric root. When evaluated with contrast enhanced computed tomography (CECT), acute peripancreatic post necrotic collections typically become lower in attenuation over time, and often appear as homogeneous fluid collections. Saponification as a complication of fat necrosis in patients with acute pancreatitis is a well recognized clinical entity. While retroperitonal fat necrosis is commonly seen on CECT, saponification is not a prominent imaging feature. We present a case of acute pancreatitis complicated by extensive saponification of fat throughout the retroperitoneum and peritoneal lining, mimicking carcinomatosis.

  12. Thymic Langerhans cell histiocytosis mimicking lymphoma.

    PubMed

    Yağci, Begül; Varan, Ali; Uner, Aysegül; Akyüz, Canan; Büyükpamukçu, Münevver

    2008-12-01

    Langerhans cell histiocytosis (LCH) is a rare disorder characterized by clonal expansion of antigen presenting Langerhans cells. Different clinical features can be seen according to the involved organs and systems. Multisystem disease with organ dysfunction is more common in infants, whereas single system disease is usually observed in older children. The disease can affect any system or organ throughout the body. Thymus is a rarely involvement site reported in LCH and usually is accompanied by skin, bone or lung disease. Here we report a 12-year-old male with thymic involvement by LCH clinically mimicking lymphoma.

  13. Brucellosis in spondyloarthritis mimicking an exacerbation.

    PubMed

    Garip, Y; Eser, F; Erten, S; Yilmaz, O; Yildirim, P

    2014-01-01

    Spondyloarthritis are a group of chronic inflammatory diseases that affect the axial skeleton, entheses and peripheral joints and may have extraarticular manifestations such as uveitis, psoriasis and inflammatory bowel disease. Brucellosis is a systemic infectious disease, endemic in Middle East, Latin America, and Mediterranean countries, which may present manifestations that resemble other diseases posing serious problems of differential diagnosis. Some hallmarks of Brucellosis may mimic a spondyloarthritis flare. In this paper, authors present a clinical case of brucellosis occurring in a patient with spondyloarthritis. Clinical symptoms initially mimicked exacerbation of spondyloarthritis.

  14. Engineering and environmental remediation scenarios due to leakage from the Gulf War oil spill using 3-D numerical contaminant modellings

    NASA Astrophysics Data System (ADS)

    Yihdego, Yohannes; Al-Weshah, Radwan A.

    2016-12-01

    The transport groundwater modelling has been undertaken to assess potential remediation scenarios and provide an optimal remediation options for consideration. The purpose of the study was to allow 50 years of predictive remediation simulation time. The results depict the likely total petroleum hydrocarbon migration pattern in the area under the worst-case scenario. The remediation scenario simulations indicate that do nothing approach will likely not achieve the target water quality within 50 years. Similarly, complete source removal approach will also likely not achieve the target water quality within 50 years. Partial source removal could be expected to remove a significant portion of the contaminant mass, but would increase the rate of contaminant recharge in the short to medium term. The pump-treat-reinject simulation indicates that the option appears feasible and could achieve a reduction in the area of the 0.01 mg/L TPH contour area for both Raudhatain and Umm Al-Aish by 35 and 30%, respectively, within 50 years. The rate of improvement and the completion date would depend on a range of factors such as bore field arrangements, pumping rates, reinjection water quality and additional volumes being introduced and require further optimisation and field pilot trials.

  15. Inflammatory Myofibroblastic Tumor Mimicking Apical Periodontitis.

    PubMed

    Adachi, Makoto; Kiho, Kazuki; Sekine, Genta; Ohta, Takahisa; Matsubara, Makoto; Yoshida, Takakazu; Katsumata, Akitoshi; Tanuma, Jun-ichi; Sumitomo, Shinichiro

    2015-12-01

    Inflammatory myofibroblastic tumors (IMTs) are rare. IMTs of the head and neck occur in all age groups, from neonates to old age, with the highest incidence occurring in childhood and early adulthood. An IMT has been defined as a histologically distinctive lesion of uncertain behavior. This article describes an unusual case of IMT mimicking apical periodontitis in the mandible of a 42-year-old man. At first presentation, the patient showed spontaneous pain and percussion pain at teeth #28 to 30, which continued after initial endodontic treatment. Panoramic radiography revealed a radiolucent lesion at the site. Cone-beam computed tomographic imaging showed osteolytic lesions, suggesting an aggressive neoplasm requiring incisional biopsy. Histopathological examination indicated an IMT. The lesion was removed en bloc under general anesthesia, and the patient manifested no clinical evidence of recurrence for 24 months. Lesions of nonendodontic origin should be included in the differential diagnosis of apical periodontitis. Every available diagnostic tool should be used to confirm the diagnosis. Cone-beam computed tomographic imaging is very helpful for differential diagnosis in IMTs mimicking apical periodontitis.

  16. Scenarios for gluino coannihilation

    DOE PAGES

    Ellis, John; Evans, Jason L.; Luo, Feng; ...

    2016-02-11

    In this article, we study supersymmetric scenarios in which the gluino is the next-to-lightest supersymmetric particle (NLSP), with a mass sufficiently close to that of the lightest supersymmetric particle (LSP) that gluino coannihilation becomes important. One of these scenarios is the MSSM with soft supersymmetry-breaking squark and slepton masses that are universal at an input GUT renormalization scale, but with non-universal gaugino masses. The other scenario is an extension of the MSSM to include vector-like supermultiplets. In both scenarios, we identify the regions of parameter space where gluino coannihilation is important, and discuss their relations to other regions of parametermore » space where other mechanisms bring the dark matter density into the range allowed by cosmology. In the case of the non-universal MSSM scenario, we find that the allowed range of parameter space is constrained by the requirement of electroweak symmetry breaking, the avoidance of a charged LSP and the measured mass of the Higgs boson, in particular, as well as the appearance of other dark matter (co)annihilation processes. Nevertheless, LSP masses mX ≲ 8TeV with the correct dark matter density are quite possible. In the case of pure gravity mediation with additional vector-like supermultiplets, changes to the anomaly-mediated gluino mass and the threshold effects associated with these states can make the gluino almost degenerate with the LSP, and we find a similar upper bound.« less

  17. Scenarios for gluino coannihilation

    SciTech Connect

    Ellis, John; Evans, Jason L.; Luo, Feng; Olive, Keith A.

    2016-02-11

    In this article, we study supersymmetric scenarios in which the gluino is the next-to-lightest supersymmetric particle (NLSP), with a mass sufficiently close to that of the lightest supersymmetric particle (LSP) that gluino coannihilation becomes important. One of these scenarios is the MSSM with soft supersymmetry-breaking squark and slepton masses that are universal at an input GUT renormalization scale, but with non-universal gaugino masses. The other scenario is an extension of the MSSM to include vector-like supermultiplets. In both scenarios, we identify the regions of parameter space where gluino coannihilation is important, and discuss their relations to other regions of parameter space where other mechanisms bring the dark matter density into the range allowed by cosmology. In the case of the non-universal MSSM scenario, we find that the allowed range of parameter space is constrained by the requirement of electroweak symmetry breaking, the avoidance of a charged LSP and the measured mass of the Higgs boson, in particular, as well as the appearance of other dark matter (co)annihilation processes. Nevertheless, LSP masses mX ≲ 8TeV with the correct dark matter density are quite possible. In the case of pure gravity mediation with additional vector-like supermultiplets, changes to the anomaly-mediated gluino mass and the threshold effects associated with these states can make the gluino almost degenerate with the LSP, and we find a similar upper bound.

  18. Attractive scenario writing.

    PubMed

    Takahashi, Yuzo; Oku, Sachiko Alexandra

    2009-05-01

    This article describes the key steps of scenario writing to facilitate problem-based learning discussion to aid student learning of basic medical science in combination with clinical medicine. The scenario has to amplify and deepen the students' thinking so that they can correlate findings from the case and knowledge from textbooks. This can be achieved in three ways: (1) a comparison of cases; (2) demonstrating a scientific link between symptoms and basic medicine; and (3) introducing a personal and emotional aspect to the scenario. A comparison of two cases enables us to shed light on the pathological differences and think about the underlying biological mechanisms. These include: (a) a comparison of two cases with similar symptoms, but different diseases; (b) a comparison of two cases with different symptoms, but the same cause; and (c) a comparison of two cases, with an easy case, followed by a complicated case. The scenarios may be disclosed in a sequence to show a scientific link between symptoms of the patient and basic medicine, which may help to cultivate a physician with a scientific mind. Examples are given by the relationship between: (a) symptoms, pathology and morphology; and (b) symptoms, pathology and physiology. When the scenario is written in such a way that students are personally and/or emotionally involved in the case, they will be more motivated in learning as if involved in the case themselves. To facilitate this, the scenario can be written in the first-person perspective. Examples include "I had a very bad headache, and vomited several times...", and "I noticed that my father was screaming at night...". The description of the events may be in chronological order with actual time, which makes students feel as if they are really the primary responding person.

  19. Hydrological and water quality impact assessment of a Mediterranean limno-reservoir under climate change and land use management scenarios

    NASA Astrophysics Data System (ADS)

    Molina-Navarro, Eugenio; Trolle, Dennis; Martínez-Pérez, Silvia; Sastre-Merlín, Antonio; Jeppesen, Erik

    2014-02-01

    Water scarcity and water pollution constitute a big challenge for water managers in the Mediterranean region today and will exacerbate in a projected future warmer world, making a holistic approach for water resources management at the catchment scale essential. We expanded the Soil and Water Assessment Tool (SWAT) model developed for a small Mediterranean catchment to quantify the potential effects of various climate and land use change scenarios on catchment hydrology as well as the trophic state of a new kind of waterbody, a limno-reservoir (Pareja Limno-reservoir), created for environmental and recreational purposes. We also checked for the possible synergistic effects of changes in climate and land use on water flow and nutrient exports from the catchment. Simulations showed a noticeable impact of climate change in the river flow regime and consequently the water level of the limno-reservoir, especially during summer, complicating the fulfillment of its purposes. Most of the scenarios also predicted a deterioration of trophic conditions in the limno-reservoir. Fertilization and soil erosion were the main factors affecting nitrate and total phosphorus concentrations. Combined climate and land use change scenarios showed noticeable synergistic effects on nutrients exports, relative to running the scenarios individually. While the impact of fertilization on nitrate export is projected to be reduced with warming in most cases, an additional 13% increase in the total phosphorus export is expected in the worst-case combined scenario compared to the sum of individual scenarios. Our model framework may help water managers to assess and manage how these multiple environmental stressors interact and ultimately affect aquatic ecosystems.

  20. Assessing Seismic Hazards - Algorithms, Maps, and Emergency Scenarios

    NASA Astrophysics Data System (ADS)

    Ferriz, H.

    2007-05-01

    Public officials in charge of building codes, land use planning, and emergency response need sound estimates of seismic hazards. Sources may be well defined (e.g., active faults that have a surface trace) or diffuse (e.g., a subduction zone or a blind-thrust belt), but in both cases one can use a deterministic or worst-case scenario approach. For each scenario, a design earthquake is selected based on historic data or the known length of Holocene ruptures (as determined by geologic mapping). Horizontal ground accelerations (HGAs) can then be estimated at different distances from the earthquake epicenter using published attenuation relations (e.g., Seismological Res. Letters, v. 68, 1997) and estimates of the elastic properties of the substrate materials. No good algorithms are available to take into account reflection of elastic waves across other fault planes (e.g., a common effect in California, where there are many strands of the San Andreas fault), or amplification of waves in water-saturated alluvial and lacustrine basins (e.g., the Mexico City basin), but empirical relations can be developed by correlating historic damage patterns with predicted HGAs. The ultimate result is a map of HGAs. With this map, and with additional data on depth to groundwater and geotechnical properties of local soils, a liquefaction susceptibility map can be prepared, using published algorithms (e.g., J. of Geotech. Geoenv. Eng., v. 127, p. 817-833, 2001; Eng. Geology Practice in N. California, p. 579-594, 2001). Finally, the HGA estimates, digital elevation models, geologic structural data, and geotechnical properties of local geologic units can be used to prepare a slope failure susceptibility map (e.g., Eng. Geology Practice in N. California, p. 77-94, 2001). Seismic hazard maps are used by: (1) Building officials to determine areas of the city where special construction codes have to be implemented, and where existing buildings may need to be retrofitted. (2) Planning officials

  1. Tsunami modeling Scenarios for the Western Black Sea, Shabla seismic area

    NASA Astrophysics Data System (ADS)

    Partheniu, Raluca; Diaconescu, Mihai; Ioane, Dumitru; Ionescu, Constantin; Marmureanu, Alexandru

    2015-04-01

    Although a rare natural phenomenon, tsunami type events in the Black Sea had been generated, past studies showing more than twenty events (Altinok Y., 1999). The western Black Sea could mostly be affected by earthquakes generated in Shabla area, the most known event being generated on 31st of March 1901, when an earthquake with Mw = 7.2 triggered tsunami waves up to 5 m height (Papadopoulos et al., 2011). In order to generate a tsunami in the Black Sea area, earthquakes should mainly follow some conditions: a) to have a magnitude Mw > 6.5; b) to have a focal depth h < 40 km and c) to have an inverse or normal fault focal mechanism. A recent earthquake generated in Shabla area on 05.08.2009, at 07:49 UTC, was taken into consideration for running tsunami scenarios. The following parameters were used as initial conditions: earthquake location (Latitude and Longitude) and one plane solution with preset fault parameters (Strike, Dip, Rake, Width, Length). A set of 18 different tsunami modeling scenarios have been run, varying the Magnitude (Mw = 7, 7.5 and 8) and the Depth (5 km, 10 km and 30 km). The software used for generating the tsunami modeling scenarios is Tsunami Analysis Tool (TAT), developed by Joint Research Centre (JRC) of the European Commission. After analyzing and comparing the generated tsunami modeling scenarios, minimum values of magnitude for tsunami waves generation were evaluated for the Shabla seismic source. For some of the scenarios no tsunami waves were generated. The worst case scenario is for a depth of 5 km, a magnitude Mw = 8, the tsunami waves heights reaching 0.8 m in Kranevo (Bulgaria). The maximum wave heights and some of the affected locations for this scenario show that at Costinesti, Mangalia, Techirghiol cities the waves will reach 0.6 m height and respectively 0.5 m at Constanta city. According to these scenarios, the tsunami generated waves can vary as follows: increasing the depth from 5 to 10 and 30 km will lead to lower heights

  2. The ShakeOut Earthquake Scenario - A Story That Southern Californians Are Writing

    USGS Publications Warehouse

    Perry, Suzanne; Cox, Dale; Jones, Lucile; Bernknopf, Richard; Goltz, James; Hudnut, Kenneth; Mileti, Dennis; Ponti, Daniel; Porter, Keith; Reichle, Michael; Seligson, Hope; Shoaf, Kimberley; Treiman, Jerry; Wein, Anne

    2008-01-01

    resulting losses are one realistic outcome, deliberately not a worst-case scenario, rather one worth preparing for and mitigating against. Decades of improving the life-safety requirements in building codes have greatly reduced the risk of death in earthquakes, yet southern California's economic and social systems are still vulnerable to large-scale disruptions. Because of this, the ShakeOut Scenario earthquake would dramatically alter the nature of the southern California community. Fortunately, steps can be taken now that can change that outcome and repay any costs many times over. The ShakeOut Scenario is the first public product of the USGS Multi-Hazards Demonstration Project, created to show how hazards science can increase a community's resiliency to natural disasters through improved planning, mitigation, and response.

  3. The SAFRR Tsunami Scenario

    USGS Publications Warehouse

    Porter, K.; Jones, Lucile M.; Ross, Stephanie L.; Borrero, J.; Bwarie, J.; Dykstra, D.; Geist, Eric L.; Johnson, L.; Kirby, Stephen H.; Long, K.; Lynett, P.; Miller, K.; Mortensen, Carl E.; Perry, S.; Plumlee, G.; Real, C.; Ritchie, L.; Scawthorn, C.; Thio, H.K.; Wein, Anne; Whitmore, P.; Wilson, R.; Wood, Nathan J.; Ostbo, Bruce I.; Oates, Don

    2013-01-01

    The U.S. Geological Survey and several partners operate a program called Science Application for Risk Reduction (SAFRR) that produces (among other things) emergency planning scenarios for natural disasters. The scenarios show how science can be used to enhance community resiliency. The SAFRR Tsunami Scenario describes potential impacts of a hypothetical, but realistic, tsunami affecting California (as well as the west coast of the United States, Alaska, and Hawaii) for the purpose of informing planning and mitigation decisions by a variety of stakeholders. The scenario begins with an Mw 9.1 earthquake off the Alaska Peninsula. With Pacific basin-wide modeling, we estimate up to 5m waves and 10 m/sec currents would strike California 5 hours later. In marinas and harbors, 13,000 small boats are damaged or sunk (1 in 3) at a cost of $350 million, causing navigation and environmental problems. Damage in the Ports of Los Angeles and Long Beach amount to $110 million, half of it water damage to vehicles and containerized cargo. Flooding of coastal communities affects 1800 city blocks, resulting in $640 million in damage. The tsunami damages 12 bridge abutments and 16 lane-miles of coastal roadway, costing $85 million to repair. Fire and business interruption losses will substantially add to direct losses. Flooding affects 170,000 residents and workers. A wide range of environmental impacts could occur. An extensive public education and outreach program is underway, as well as an evaluation of the overall effort.

  4. Biomass Scenario Model

    SciTech Connect

    2015-09-01

    The Biomass Scenario Model (BSM) is a unique, carefully validated, state-of-the-art dynamic model of the domestic biofuels supply chain which explicitly focuses on policy issues, their feasibility, and potential side effects. It integrates resource availability, physical/technological/economic constraints, behavior, and policy. The model uses a system dynamics simulation (not optimization) to model dynamic interactions across the supply chain.

  5. Inherited cardiomyopathies mimicking arrhythmogenic right ventricular cardiomyopathy.

    PubMed

    Roberts, Jason D; Veinot, John P; Rutberg, Julie; Gollob, Michael H

    2010-01-01

    Arrhythmogenic right ventricular cardiomyopathy (ARVC) represents an inherited cardiomyopathy that manifests clinically with malignant ventricular arrhythmias, sudden cardiac death, and less commonly heart failure. The condition is characterized by replacement of the myocardium, primarily of the right ventricle, with fibrofatty tissue. Extensive fibrofatty replacement of the myocardium has been previously thought to be pathognomonic of ARVC; however, this report details two other forms of inherited cardiomyopathy, namely hypertrophic cardiomyopathy (HCM) and the PRKAG2 cardiac syndrome, that were found to have significant fibrofatty myocardial replacement at pathologic examination. This report represents the first documentation of inherited cardiomyopathies mimicking ARVC and highlights the concept that other cardiac conditions can be associated with fibrofatty replacement of the myocardium.

  6. A subtle mimicker in emergency department

    PubMed Central

    Angelis, Maria Vittoria De; Giacomo, Roberta Di; Muzio, Antonio Di; Onofrj, Marco; Bonanni, Laura

    2016-01-01

    Abstract Background: Movement disorder emergencies include any movement disorder which develops over hours to days, in which failure to appropriately diagnose and manage can result in patient morbidity or mortality. Movement disorder emergencies include acute dystonia: sustained or intermittent muscle contractions causing abnormal, often repetitive, movements. Acute dystonia is a serious challenge for emergency room doctors and neurologists, because of the high probability of misdiagnosis, due to the presence of several mimickers including partial seizures, meningitis, localized tetanus, serum electrolyte level abnormalities, strychnine poisoning, angioedema, malingering, catatonia, and conversion. Methods: We describe 2 examples, accompanied by videos, of acute drug-induced oro-mandibular dystonia, both subsequent to occasional haloperidol intake. Results: Management and treatment of this movement disorder are often difficult: neuroleptics withdrawal, treatment with benzodiazepines, and anticholinergics are recommended. Conclusion: Alternative treatment options are also discussed. PMID:27741141

  7. Tentorium schwannoma mimicking meningioma: an unusual location.

    PubMed

    Calişaneller, Tarkan; Ozen, Ozlem; Altinörs, Nur; Caner, Hakan

    2008-07-01

    A 60-year-old female was admitted to our clinic complaining of a long-lasting headache. Cranial magnetic resonance imagining examination of the patient revealed a 22x24 mm extra-axial, well-demarcated, mass lesion based on the left tentorium. The patient underwent a craniotomy and the tumor was totally excised with the adjacent tentorium. The histopathological examination of the tumor complied with the diagnosis of schwannoma. The rest of the clinical course was uneventful and the patient was released from the hospital without any neurological deficit. Intracranial schwannomas can rarely originate from atypical dural locations and radiological techniques are not always helpful in distinguishing tentorial schwannoma from tentorial meningioma. We presented a patient with a tentorium schwannoma mimicking meningioma and discussed the current literature.

  8. Pulmonary artery sarcoma mimicking pulmonary thromboembolism.

    PubMed

    Celik, Gökhan; Ciledağ, Aydin; Yüksel, Cabir; Yenigün, Bülent Mustafa; Kutlay, Hakan; Yazicıoğlu, Levent; Perçinel, Sibel; Kaya, Akin

    2011-01-01

    A 30 years old male patient was referred to our hospital with a diagnosis of pulmonary thromboembolism due to thorax-computerized tomography (CT) angiography, revealing a thrombus totally occluding left main pulmonary artery. The lesion was evaluated as tumoural mass. Positron emission tomography (PET)-CT revealed pathologic uptake at pulmonary artery mass. Due to localization of tumour, left pneumonectomy was performed. The pathological diagnosis revealed to be pulmonary artery sarcoma. The patient was presented because pulmonary artery sarcomas are very rare tumors and can mimick pulmonary thromboembolism. The true prevalence is underestimated as many pulmonary artery sarcomas are misdiagnosed as pulmonary thromboembolism. PET-CT may help to make a differential diagnosis.

  9. High-altitude cerebral oedema mimicking stroke

    PubMed Central

    Yanamandra, Uday; Gupta, Amul; Patyal, Sagarika; Varma, Prem Prakash

    2014-01-01

    High-altitude cerebral oedema (HACO) is the most fatal high-altitude illness seen by rural physicians practising in high-altitude areas. HACO presents clinically with cerebellar ataxia, features of raised intracranial pressure (ICP) and coma. Early identification is important as delay in diagnosis can be fatal. We present two cases of HACO presenting with focal deficits mimicking stroke. The first patient presented with left-sided hemiplegia associated with the rapid deterioration in the sensorium. Neuroimaging revealed features suggestive of vasogenic oedema. The second patient presented with monoplegia of the lower limb. Neuroimaging revealed perfusion deficit in anterior cerebral artery territory. Both patients were managed with dexamethasone and they improved dramatically. Clinical picture and neuroimaging closely resembled acute ischaemic stroke in both cases. Thrombolysis in these patients would have been disastrous. Recent travel to high altitude, young age, absence of atherosclerotic risk factors and features of raised ICP concomitantly directed the diagnosis to HACO. PMID:24671373

  10. Infant botulism mimicking an acute abdomen.

    PubMed

    Pisanti, R; Vitiello, R; Formicola, S; Pisanti, A

    2009-12-01

    Botulism is the acute, flaccid paralysis caused by a neurotoxin produced by Clostridium botulinum. In the infant, clinical symptoms are usually unspecific such as poor feeding, weak suck, feeble cry, drooling, followed by a symmetric, descending, flaccid paralysis beginning with the cranial nerve musculature. The initial symptoms of the disease are often similar to several diseases and therefore differential diagnosis is very difficult and rarely suspected by the physician. Since 2004 only 22 cases of infant botulism have been reported in Italy. Since most paediatricians are unfamiliar with the clinical manifestations of infant botulism, the diagnosis can be easily missed. Hence the disease may well be underestimated and underreported. We report a clinical case of botulism presenting initially with abdominal distention, thereby mimicking acute abdomen.

  11. Mimicking Nonequilibrium Steady States with Time-Periodic Driving

    NASA Astrophysics Data System (ADS)

    Raz, O.; Subaşı, Y.; Jarzynski, C.

    2016-04-01

    Under static conditions, a system satisfying detailed balance generically relaxes to an equilibrium state in which there are no currents. To generate persistent currents, either detailed balance must be broken or the system must be driven in a time-dependent manner. A stationary system that violates detailed balance evolves to a nonequilibrium steady state (NESS) characterized by fixed currents. Conversely, a system that satisfies instantaneous detailed balance but is driven by the time-periodic variation of external parameters—also known as a stochastic pump (SP)—reaches a periodic state with nonvanishing currents. In both cases, these currents are maintained at the cost of entropy production. Are these two paradigmatic scenarios effectively equivalent? For discrete-state systems, we establish a mapping between nonequilibrium stationary states and stochastic pumps. Given a NESS characterized by a particular set of stationary probabilities, currents, and entropy production rates, we show how to construct a SP with exactly the same (time-averaged) values. The mapping works in the opposite direction as well. These results establish a proof of principle: They show that stochastic pumps are able to mimic the behavior of nonequilibrium steady states, and vice versa, within the theoretical framework of discrete-state stochastic thermodynamics. Nonequilibrium steady states and stochastic pumps are often used to model, respectively, biomolecular motors driven by chemical reactions and artificial molecular machines steered by the variation of external, macroscopic parameters. Our results loosely suggest that anything a biomolecular machine can do, an artificial molecular machine can do equally well. We illustrate this principle by showing that kinetic proofreading, a NESS mechanism that explains the low error rates in biochemical reactions, can be effectively mimicked by a constrained periodic driving.

  12. Assessments of direct human exposure: the approach of EU risk assessments compared to scenario-based risk assessment.

    PubMed

    Wormuth, Matthias; Demou, Evangelia; Scheringer, Martin; Hungerbühler, Konrad

    2007-08-01

    The awareness of potential risks emerging from the use of chemicals in all parts of daily life has increased the need for risk assessments that are able to cover a high number of exposure situations and thereby ensure the safety of workers and consumers. In the European Union (EU), the practice of risk assessments for chemicals is laid down in a Technical Guidance Document; it is designed to consider environmental and human occupational and residential exposure. Almost 70 EU risk assessment reports (RARs) have been finalized for high-production-volume chemicals during the last decade. In the present study, we analyze the assessment of occupational and consumer exposure to trichloroethylene and phthalates presented in six EU RARs. Exposure scenarios in these six RARs were compared to scenarios used in applications of the scenario-based risk assessment approach to the same set of chemicals. We find that scenarios used in the selected EU RARs to represent typical exposure situations in occupational or private use of chemicals and products do not necessarily represent worst-case conditions. This can be due to the use of outdated information on technical equipment and conditions in workplaces or omission of pathways that can cause consumer exposure. Considering the need for exposure and risk assessments under the new chemicals legislation of the EU, we suggest that a transparent process of collecting data on exposure situations and of generating representative exposure scenarios is implemented to improve the accuracy of risk assessments. Also, the data sets used to assess human exposure should be harmonized, summarized in a transparent fashion, and made accessible for all risk assessors and the public.

  13. Experimental Evaluation of PV Inverter Anti-Islanding with Grid Support Functions in Multi-Inverter Island Scenarios

    SciTech Connect

    Hoke, Anderson; Nelson, Austin; Miller, Brian; Chakraborty, Sudipta; Bell, Frances; McCarty, Michael

    2016-07-01

    based anti-islanding tests to determine the worst-case configuration of grid support functions for each inverter. A grid support function is a function an inverter performs to help stabilize the grid or drive the grid back towards its nominal operating point. The four grid support functions examined here were voltage ride-through, frequency ride-through, Volt-VAr control, and frequency-Watt control. The worst-case grid support configuration was defined as the configuration that led to the maximum island duration (or run-on time, ROT) out of 50 tests of each inverter. For each of the three inverters, it was observed that maximum ROT increased when voltage and frequency ride-through were activated. No conclusive evidence was found that Volt-VAr control or frequency-Watt control increased maximum ROT. Over all single-inverter test cases, the maximum ROT was 711 ms, well below the two-second limit currently imposed by IEEE Standard 1547-2003. A subsequent series of 244 experiments tested all three inverters simultaneously in the same island. These tests again used a procedure based on the IEEE 1547.1 unintentional islanding test to create a difficult-to-detect island condition. For these tests, which used the two worst-case grid support function configurations from the single-inverter tests, the inverters were connected to a variety of island circuit topologies designed to represent the variety of multiple-inverter islands that may occur on real distribution circuits. The interconnecting circuits and the resonant island load itself were represented in the real-time PHIL model. PHIL techniques similar to those employed here have been previously used and validated for anti-islanding tests, and the PHIL resonant load model used in this test was successfully validated by comparing single-inverter PHIL tests to conventional tests using an RLC load bank.

  14. Uncertainty in local and regional tsunami earthquake source parameters: Implications for scenario based hazard assessment and forecasting

    NASA Astrophysics Data System (ADS)

    Müller, Christof; Power, William; Burbidge, David; Wang, Xiaoming

    2016-04-01

    Over the last decade tsunami propagation models have been used extensively for both tsunami forecasting, hazard and risk assessment. However, the effect of uncertainty in the earthquake source parameters, such as location and distribution of slip in the earthquake source on the results of the tsunami model has not always been examined in great detail. We have developed a preliminary combined and continuous Hikurangi-Kermadec subduction zone interface model. The model is defined by a spline surface and is based on a previously published spline model for Hikurangi interface and a more traditional unit source model for the Kermadec interface. The model allows to freely position and vary the earthquake epicenter and to consider non-uniform slip. Using this model we have investigated the effects of variability in non-uniform slip and epicenter location on the distribution of offshore maximum wave heights for local New Zealand targets. Which scenario out of an ensemble is responsible for the maximum wave height locally is a spatially highly variable function of earthquake location and/or the distribution of slip. We use the Coefficient of Variation (CoV) to quantify the variability of offshore wave heights as a function of source location and distribution of slip. CoV increases significantly with closer proximity to the shore, in bays and in shallow water. The study has implication for tsunami hazard assessment and forecasting. As an example, our results challenge the concept of hazard assessment using a single worst case scenario in particular for local tsunami.

  15. Evolving practices in environmental scenarios: a new scenario typology

    NASA Astrophysics Data System (ADS)

    Wilkinson, Angela; Eidinow, Esther

    2008-10-01

    A new approach to scenarios focused on environmental concerns, changes and challenges, i.e. so-called 'environmental scenarios', is necessary if global environmental changes are to be more effectively appreciated and addressed through sustained and collaborative action. On the basis of a comparison of previous approaches to global environmental scenarios and a review of existing scenario typologies, we propose a new scenario typology to help guide scenario-based interventions. This typology makes explicit the types of and/or the approaches to knowledge ('the epistemologies') which underpin a scenario approach. Drawing on previous environmental scenario projects, we distinguish and describe two main types in this new typology: 'problem-focused' and 'actor-centric'. This leads in turn to our suggestion for a third type, which we call 'RIMA'—'reflexive interventionist or multi-agent based'. This approach to scenarios emphasizes the importance of the involvement of different epistemologies in a scenario-based process of action learning in the public interest. We suggest that, by combining the epistemologies apparent in the previous two types, this approach can create a more effective bridge between longer-term thinking and more immediate actions. Our description is aimed at scenario practitioners in general, as well as those who work with (environmental) scenarios that address global challenges.

  16. Mammary analogue secretory carcinoma mimicking salivary adenoma.

    PubMed

    Williams, Lindsay; Chiosea, Simion I

    2013-12-01

    Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor characterized by ETV6 translocation. It appears that prior studies have identified MASC by reviewing salivary gland carcinomas, such as acinic cell carcinoma and adenocarcinoma, not otherwise specified. To address the possibility of MASC mimicking benign salivary neoplasms we reviewed 12 salivary gland (cyst)adenomas diagnosed prior to the discovery of MASC. One encapsulated (cyst)adenoma of the parotid gland demonstrated features of MASC. The diagnosis was confirmed by fluorescence in situ hybridization with an ETV6 break-apart probe. An unusual complex pattern of ETV6 rearrangement with duplication of the telomeric/distal ETV6 probe was identified. This case illustrates that MASC may mimic salivary (cyst)adenomas. To more accurately assess true clinical and morphologic spectrum of MASC, future studies may have to include review of salivary (cyst)adenomas. The differential diagnosis of MASC may have to be expanded to include cases resembling salivary (cyst)adenomas.

  17. Vitamin D Deficiency Rickets Mimicking Pseudohypoparathyroidism

    PubMed Central

    Kurtoğlu, Selim; Yıldız, Aysel; Akın, Mustafa Ali; Kendirici, Mustafa

    2010-01-01

    Vitamin D deficiency rickets (VDDR) is a disorder biochemically characterized by elevated serum alkaline phosphatase (ALP) activity, normal or decreased serum calcium (Ca) and inorganic phosphate concentrations, secondary hyperparathyroidism and decreased serum 25−hydroxyvitamin D (25(OH)D) levels. In stage 1 VDDR, urinary amino acid and phosphate excretion are normal with minimal or no findings of rickets on radiographs. Pseudohypoparathyroidism (PHP) is an inherited disorder characterized by end−organ resistance to parathormone (PTH). VDDR occasionally resembles PHP type 2 in clinical presentation and biochemical features, creating difficulties in the differential diagnosis of these two entities. Here we report an infant diagnosed with VDDR. In addition to inadequate vitamin D intake, usage of antiepileptic drugs (AED) may have led to the worsening of the vitamin D deficiency. The patient presented with a history of febrile convulsions, for which he received phenobarbital treatment. The initial findings of hypocalcemia, hyperphosphatemia and normal tubular reabsorption of phosphate, mimicking PHP 2, responded well to vitamin D and oral Ca treatment with normalization of serum Ca, phosphorus (P), ALP and PTH levels Conflict of interest:None declared. PMID:21274319

  18. Pontine lesions mimicking acute peripheral vestibulopathy

    PubMed Central

    Thomke, F.; Hopf, H. C.

    1999-01-01

    OBJECTIVES—Clinical signs of acute peripheral vestibulopathy (APV) were repeatedly reported with pontine lesions. The clinical relevance of such a mechanism is not known, as most studies were biased by patients with additional clinical signs of brainstem dysfunction.
METHODS—Masseter reflex (MassR), blink reflex (BlinkR), brainstem auditory evoked potentials (BAEPs), and DC electro-oculography (EOG) were tested in 232 consecutive patients with clinical signs of unilateral APV.
RESULTS—Forty five of the 232 patients (19.4%) had at least one electrophysiological abnormality suggesting pontine dysfunction mainly due to possible vertebrobasilar ischaemia (22 patients) and multiple sclerosis (eight patients). MassR abnormalities were seen in 24patients, and EOG abnormalities of saccades and following eye movements occurred in 22 patients. Three patients had BlinkR-R1 abnormalities, and one had delayed BAEP waves IV and V. Clinical improvement was almost always (32 of 34 re-examined patients) associated with improvement or normalisation of at least one electrophysiological abnormality. Brain MRI was done in 25 of the 44 patients and confirmed pontine lesions in six (two infarcts, three inflammations, one tumour).
CONCLUSIONS—Pontine dysfunction was suggested in 45 of 232 consecutive patients with clinical signs of APV on the basis of abnormal electrophysiological findings, and was mainly attributed to brainstem ischaemia and multiple sclerosis. The frequency of pontine lesions mimicking APV is underestimated if based on MRI established lesions only.

 PMID:10084533

  19. Egg white ovalbumin digestion mimicking physiological conditions.

    PubMed

    Martos, Gustavo; Contreras, Patricia; Molina, Elena; López-Fandiño, Rosina

    2010-05-12

    Gastrointestinal digestion of ovalbumin (OVA) was simulated using an in vitro system in two steps, which mimicked digestion in the stomach and duodenum, to assess the effect of different gastric pHs, different concentrations of proteases, and the presence of surfactants, such as phosphatidylcholine (PC) and bile salts (BS). OVA was very resistant to pepsin action at an enzyme/substrate ratio that would resemble a physiological situation (1:20 w/w, 172 units/mg) at pH values equal or above 2. The presence of PC did not change the susceptibility of OVA to proteolysis with pepsin. Fluorescence experiments showed that OVA interacted with PC vesicles, particularly at acidic pH, but it is likely that the protein maintained a high degree of conformational stability, resisting pepsin action. The presence of BS at physiological concentrations considerably increased the proteolysis of OVA by a mixture of pancreatic enzymes. The addition of PC made OVA even more sensitive to proteolytic degradation, suggesting that OVA could associate with the surfactants under duodenal conditions, increasing its exposure to pancreatic proteinases. Immunoreactivity against IgE from sera of allergic patients was retained after in vitro gastric digestion, depending on the reactivity of the sera, but it decreased considerably after in vitro duodenal digestion.

  20. Non-harmful insertion of data mimicking computer network attacks

    DOEpatents

    Neil, Joshua Charles; Kent, Alexander; Hash, Jr, Curtis Lee

    2016-06-21

    Non-harmful data mimicking computer network attacks may be inserted in a computer network. Anomalous real network connections may be generated between a plurality of computing systems in the network. Data mimicking an attack may also be generated. The generated data may be transmitted between the plurality of computing systems using the real network connections and measured to determine whether an attack is detected.

  1. Biomass Scenario Model Scenario Library: Definitions, Construction, and Description

    SciTech Connect

    Inman, D.; Vimmerstedt, L.; Bush, B.; Peterson, S.

    2014-04-01

    Understanding the development of the biofuels industry in the United States is important to policymakers and industry. The Biomass Scenario Model (BSM) is a system dynamics model of the biomass-to-biofuels system that can be used to explore policy effects on biofuels development. Because of the complexity of the model, as well as the wide range of possible future conditions that affect biofuels industry development, we have not developed a single reference case but instead developed a set of specific scenarios that provide various contexts for our analyses. The purpose of this report is to describe the scenarios that comprise the BSM scenario library. At present, we have the following policy-focused scenarios in our library: minimal policies, ethanol-focused policies, equal access to policies, output-focused policies, technological diversity focused, and the point-of-production- focused. This report describes each scenario, its policy settings, and general insights gained through use of the scenarios in analytic studies.

  2. Repository preclosure accident scenarios

    SciTech Connect

    Yook, H.R.; Arbital, J.G.; Keeton, J.M.; Mosier, J.E.; Weaver, B.S.

    1984-09-01

    Waste-handling operations at a spent-fuel repository were investigated to identify operational accidents that could occur. The facility was subdivided, through systems engineering procedures, into individual operations that involve the waste and one specific component of the waste package, in one specific area of the handling facility. From this subdivision approximately 600 potential accidents involving waste package components were identified and then discussed. Supporting descriptive data included for each accident scenario are distance of drop, speed of collision, weight of package component, and weight of equipment involved. The energy of impact associated with each potential accident is calculated to provide a basis for comparison of the relative severities of all the accidents. The results and conclusions suggest approaches to accident consequence mitigation through waste package and facility design. 35 figures, 9 tables.

  3. Scenario-based assessment of buildings damage and population exposure due to tsunamis for the town of Alexandria, Egypt

    NASA Astrophysics Data System (ADS)

    Pagnoni, G.; Armigliato, A.; Tinti, S.

    2015-08-01

    Alexandria is the second biggest city in Egypt as regards population, is a key economic area in northern Africa and has a very important tourist activity. Historical catalogues indicate that it was severely affected by a number of tsunami events. In this work we assess the tsunami hazard by running numerical simulations of tsunami impact in Alexandria through the Worst-case Credible Tsunami Scenario Analysis (WCTSA). We identify three main seismic sources: the Western Hellenic Arc (WHA - reference event AD 365, Mw = 8.5), the Eastern Hellenic Arc (EHA - reference event 1303, Mw = 8.0) and the Cyprus Arc (CA - hypothetical scenario earthquake with Mw = 8.0), inferred from the tectonic setting and from historical tsunami catalogues. All numerical simulations are carried out by means of the code UBO-TSUFD, developed and maintained by the Tsunami Research Team of the University of Bologna. Relevant tsunami metrics are computed for each scenario and then used to build aggregated fields such as the maximum flood depth and the maximum inundation area. We find that the case that produces the most relevant flooding in Alexandria is the EHA scenario, with wave heights up to 4 m. The aggregate fields are used for a building vulnerability assessment according to a methodology developed in the frame of the EU-FP6 project SCHEMA and further refined in this study, based on the adoption of a suitable building damage matrix and on water inundation depth. It is found that in the districts of El Dekhila and Al Amriyah, to the south-west of the port of Dekhila over 12 000 buildings could be affected and hundreds of them could incur in consequences ranging from important damage to total collapse. It is also found that in the same districts tsunami inundation covers an area of about 15 km2 resulting in more than 150 000 residents being exposed.

  4. Noncavernous arteriovenous shunts mimicking carotid cavernous fistulae

    PubMed Central

    Kobkitsuksakul, Chai; Jiarakongmun, Pakorn; Chanthanaphak, Ekachat; Singhara Na Ayudya, Sirintara (Pongpech)

    2016-01-01

    PURPOSE The classic symptoms and signs of carotid cavernous sinus fistula or cavernous sinus dural arteriovenous fistula (AVF) consist of eye redness, exophthalmos, and gaze abnormality. The angiography findings typically consist of arteriovenous shunt at cavernous sinus with ophthalmic venous drainage with or without cortical venous reflux. In rare circumstances, the shunts are localized outside the cavernous sinus, but mimic symptoms and radiography of the cavernous shunt. We would like to present the other locations of the arteriovenous shunt, which mimic the clinical presentation of carotid cavernous fistulae, and analyze venous drainages. METHODS We retrospectively examined the records of 350 patients who were given provisional diagnoses of carotid cavernous sinus fistulae or cavernous sinus dural AVF in the division of Interventional Neuroradiology, Ramathibodi Hospital, Bangkok between 2008 and 2014. Any patient with cavernous arteriovenous shunt was excluded. RESULTS Of those 350 patients, 10 patients (2.85%) were identified as having noncavernous sinus AVF. The angiographic diagnoses consisted of three anterior condylar (hypoglossal) dural AVF, two traumatic middle meningeal AVF, one lesser sphenoid wing dural AVF, one vertebro-vertebral fistula (VVF), one intraorbital AVF, one direct dural artery to cortical vein dural AVF, and one transverse-sigmoid dural AVF. Six cases (60%) were found to have venous efferent obstruction. CONCLUSION Arteriovenous shunts mimicking the cavernous AVF are rare, with a prevalence of only 2.85% in this series. The clinical presentation mainly depends on venous outflow. The venous outlet of the arteriovenous shunts is influenced by venous afferent-efferent patterns according to the venous anatomy of the central nervous system and the skull base, as well as by architectural disturbance, specifically, obstruction of the venous outflow. PMID:27767958

  5. Natural Disaster Scenarios in the Food Security Early Warning Contingency Planning Process: The Role of Remotely Sensed Vegetation and Rainfall Data

    NASA Astrophysics Data System (ADS)

    Brown, M. E.; Funk, C. C.; Choularton, R.

    2006-12-01

    In this talk, we will explore how scenarios are used in early warning systems in Africa as they respond to the food security consequences of droughts and floods, and determine ways EWS could use remote sensing products more effectively. Early warning of an incipient agricultural drought triggers the contingency planning process at the national governmental level, supported by international organizations such as USAID's Famine Early Warning Network or FEWS NET. Contingency planning focuses on updating relevant national contingency plans. These scenarios are usually described as `Worst Case', `Mid-Case', and `Best Case', and focus on providing guidance for humanitarian organizations' assistance planning process. There is an increasingly apparent need to provide appropriate, nuanced, and constructive assistance. Remote sensing can support this objective by providing earlier early warning, giving aid organizations the time necessary to coordinate effective aid packages and policies. In this talk we will explore how recently developed projections of vegetation data one to four months into the future could be used to guide the scenarios both spatially and temporally, and provide probabilities for which case is most likely to occur. A case study of Ethiopia and its contingency planning process for the past few years will be presented.

  6. Restless legs syndrome mimicking S1 radiculopathy.

    PubMed

    Zambelis, Th; Wolgamuth, B R; Papoutsi, S N; Economou, N T

    2016-01-01

    mimicking several pathological conditions, Restless Legs Syndrome prevalence on general population according to various large epidemiological studies and pathogenic hypotheses on the issue of Restless Legs Syndrome are discussed. Finally, by presenting another possible "RLS-mimic" our aim is to highlight the common misdiagnosis of Restless Legs Syndrome, which can mimic a variety of disorders, some of which are very common, such as an S1 radiculopathy, thus raising concern among doctors of various specialties addressed to by Restless Legs Syndrome sufferers, on the importance of proper diagnosis of the syndrome.

  7. Learning from global emissions scenarios

    NASA Astrophysics Data System (ADS)

    O'Neill, Brian C.; Nakicenovic, Nebojsa

    2008-10-01

    Scenarios of global greenhouse gas emissions have played a key role in climate change analysis for over twenty years. Currently, several research communities are organizing to undertake a new round of scenario development in the lead-up to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC). To help inform this process, we assess a number of past efforts to develop and learn from sets of global greenhouse gas emissions scenarios. We conclude that while emissions scenario exercises have likely had substantial benefits for participating modeling teams and produced insights from individual models, learning from the exercises taken as a whole has been more limited. Model comparison exercises have typically focused on the production of large numbers of scenarios while investing little in assessing the results or the production process, perhaps on the assumption that later assessment efforts could play this role. However, much of this assessment potential remains untapped. Efforts such as scenario-related chapters of IPCC reports have been most informative when they have gone to extra lengths to carry out more specific comparison exercises, but in general these assessments do not have the remit or resources to carry out the kind of detailed analysis of scenario results necessary for drawing the most useful conclusions. We recommend that scenario comparison exercises build-in time and resources for assessing scenario results in more detail at the time when they are produced, that these exercises focus on more specific questions to improve the prospects for learning, and that additional scenario assessments are carried out separately from production exercises. We also discuss the obstacles to better assessment that might exist, and how they might be overcome. Finally, we recommend that future work include much greater emphasis on understanding how scenarios are actually used, as a guide to improving scenario production.

  8. Impacts of Mega-droughts on Water and Food Security in the Indo-Gangetic Plains: A Paleoclimate Scenario Analysis

    NASA Astrophysics Data System (ADS)

    Zhu, T.; Pitois, G.; Ringler, C.; Wang, D.; Rosegrant, M. W.

    2014-12-01

    Spanning over Pakistan, northern India, Nepal, and Bangladesh, the Indo-Gangetic Plains (IGP) is the home of several hundred million people and the "bread basket" for much of South Asia. The flat terrain, fertile soils, and favorable climate of the IGP make it agriculturally productive. However prolonged droughts caused by consecutive monsoon failures can seriously affect crop production and social wellbeing, in particular for the eastern part of the plains where agriculture remains largely rain-fed. Severe droughts were observed in the IGP historically, and recent paleoclimate studies reveal that more severe and long-lasting "mega-droughts" had happened in the distant past. Agricultural losses from major droughts can dramatically affect food systems and increase the vulnerability of resource-poor people given the delicate balance between food supply and demand under growing natural resource scarcity. To estimate the potential impacts of "mega-droughts" on the water and food systems in the IGP, we develop worst-case drought scenarios through inverse modeling of tree-ring-based PDSI reconstruction that covers the period 1300-1899 (A.D.), and analyze these historic mega-drought scenarios using IFPRI's IMPACT global water and food projections model. The base year of the IMPACT model is parameterized using socioeconomic and engineering data that reflect today's water management and infrastructure, agricultural technologies, population, income, and market institutions. The base year simulation is validated against observations to ensure model fidelity. Anticipated changes of the above factors in the future out to 2050 are specified using demographic and economic growth projections and literature data. Model simulation results represent the consequences of mega-droughts in the IGP given technological and socioeconomic conditions of today and in the future. We also explore policy options for increasing the resilience of water and food systems in the IGP, through scenario

  9. Munchausen syndrome mimicking psychiatric disease with concomitant genuine physical illness

    PubMed Central

    Almeida, Jaime; da Silva, Joaquim Alves; Xavier, Miguel; Gusmão, Ricardo

    2010-01-01

    Munchausen syndrome is a disorder in which patients intentionally produce symptoms mimicking physical or psychiatric illnesses with the aim to assume the sick role and to gain medical attention. Once a patient receives a Munchausen syndrome diagnosis every complaint made thence tends to be regarded with scepticism by clinical staff. However, it is possible that a bona fide illness, which might be disregarded, may coexist in these patients. We report a case of MS mimicking psychiatric disease with concomitant genuine acute physical illness. Despite the initial doubts about the veracity of the latter, due to its prompt recognition, treatment was successful. PMID:22798096

  10. Tsunami inundation scenarios and tsunami vulnerability assessment for the town of Alexandria, Egypt

    NASA Astrophysics Data System (ADS)

    Tinti, S.; Pagnoni, G.; Armigliato, A.; Tonini, R.

    2012-04-01

    Historical catalogues indicate that Alexandria was severely affected in the past by several tsunami events. The tsunami hazard in that area is mainly due to far-field tectonic sources. The two most famous earthquakes that generated tsunamis whose impact was experienced also by Alexandria and the surrounding area are the 365 AD and the 1303 earthquakes, whose sources are still a matter of debate but are frequently located in correspondence with the western and eastern sectors of the Hellenic Arc. Nowadays, Alexandria is the second biggest city in Egypt as regards population (3.9 million), it is a key economic area in northern Africa and it has a very important tourist activity. Hence the proper assessment of tsunami hazard-to-risk must be regarded as an important task, which was partially undertaken in the very recent past by projects such as TRANSFER (EU-FP6). It is also worth mentioning that the overall eastern Mediterranean is one of the areas chosen by the EU-FP7 Project TRIDEC to test a new generation Tsunami Early Warning Decision Support System. We assess the hazard by performing numerical simulations of tsunami impact in Alexandria through the worst-case scenario technique. We identify three main seismic sources: the western Hellenic Arc (reference event 365 AD, magnitude 8.3), the eastern Hellenic Arc (reference event 1303, magnitude 8.0) and the Cyprus arc (hypothetical scenario with magnitude 8.0, inferred from the tectonic setting and the historical seismic catalogues). All the simulations and the inundation maps are computed by means of the UBO-TSUFD code, developed and maintained by the Tsunami Research team of the University of Bologna, which solves the non-linear shallow-water equations allowing for the computation of run-up and inundation on nested grids. For each of the considered scenarios we compute all the relevant tsunami metrics, i.e. water elevation, current speed, flow depth and momentum flux. We find that the case that produces the most

  11. Student Rights and Responsibilities Scenarios.

    ERIC Educational Resources Information Center

    Peterson, Ludwig A.; And Others

    To stimulate interest in student's rights and responsibilities, this resource contains incomplete scenarios dealing with the consequences of knowing and not knowing the law, as it is applied to modern practical situations. The scenarios can be used in high school courses such as government, social problems, history, psychology, and business law.…

  12. Futures Scenario in Science Learning

    ERIC Educational Resources Information Center

    Lloyd, David; Vanderhout, Annastasia; Lloyd, Lisa; Atkins, David

    2010-01-01

    In this article we describe our experiences in developing futures scenarios in two science contexts, space science and atmospheric science/climate change. Futures scenario writing can develop scientific literacy by connecting science learning to students' lifeworlds--past, present and future. They also provide a synthesising mechanism for…

  13. Sudden early-morning awakening impairs immediate tactical planning in a changing 'emergency' scenario.

    PubMed

    Horne, Jim; Moseley, Robert

    2011-06-01

    This was a realistic military-type exercise assessing unexpected, abrupt early-morning awakening effects on immediate 'executive function' and the ability to comprehend and deal with a sudden emergency under a changing situation. Twenty (average age 21years) healthy, highly motivated junior officer reservists were assigned randomly to two equal, independent groups, unforewarned as to what would happen. The experimental group was woken abruptly at 03:00h (<3h sleep) and confronted immediately with a 'paper exercise' of an enemy attack, requiring a feasible plan of engagement with minimal loss of resources, to be completed within 15min. A control group slept until 07:30h; they were then presented with the identical emergency 1h later. Participants worked individually, under time pressure, receiving written information, map and other details, all containing relevant, irrelevant and misleading information. Halfway through, they were given (unexpectedly) a critical update necessitating a change of tactics. Performance was scored blind by instructors, under five categories. Eight of the experimental group versus three controls failed overall, with significant group differences on three specific categories relying on flexible decision-making: 'identification of available cover', 'use of available assets' and 'extraction of relevant from irrelevant information'. Other, logical and highly trained skills were unimpaired. Ours was a 'worst case scenario', combining short sleep, circadian 'trough' and sleep inertia, all of which differentiated the two groups, unlike typical laboratory studies. Nevertheless, it was relevant to real-life situations involving highly motivated, trained individuals making critical innovative decisions in the early morning versus the normal waking day.

  14. Cutaneous lymphoid hyperplasia mimicking cutaneous lymphoma in a hyperthyroid cat.

    PubMed

    Snead, Elisabeth; Kerr, Moira; Macdonald, Valerie

    2013-10-01

    A 12-year-old neutered male domestic shorthair cat presented for chronic, localized, swelling and crusting of the left upper lip, weight loss, sporadic vomiting, and focal alopecia between the scapulae was diagnosed with hyperthyroidism and regional eosinophilic lymphadenitis. Treatment with methimazole exacerbated an underlying hypersensitivity disorder leading to marked generalized lymphadenopathy that histologically mimicked lymphoma.

  15. Osteoid osteoma of the radial styloid mimicking de quervain tenosynovitis.

    PubMed

    Chloros, George D; Themistocleous, George S; Papagelopoulos, Panayiotis J; Khaldi, Lubna; Efstathopoulos, Dimitrios G; Soucacos, Panayotis N

    2007-10-01

    A very unusual location of osteoid osteoma arising in the radial styloid is presented, which strongly mimicked de Quervain tenosynovitis, thereby resulting in the patient undergoing an additional unnecessary operation and a substantial delay of more than 2 years in diagnosis.

  16. [Ectopic pancreas mimicking advanced gastric malignancy--case report].

    PubMed

    Zawada, Iwona; Lewosiuk, Agnieszka; Hnatyszyn, Krzysztof; Patalan, Michał; Woyke, Stanisław; Kostyrka, Roman; Marlicz, Krzysztof; Starzyńska, Teresa

    2012-04-01

    Ectopic pancreas is the most common type of ectopic tissue in gastrointestinal tract. It is typically asymptomatic, presenting as a small submucosal lesion in prepyloric region of stomach. The diagnosis is usually incidental, during gastroscopy. The patient with symptomatic heterotropic pancreas, mimicking gastric malignancy was described.

  17. Headache attributed to unruptured saccular aneurysm, mimicking hemicrania continua.

    PubMed

    Vikelis, Michail; Xifaras, Michail; Magoufis, Georgios; Gekas, Georgios; Mitsikostas, Dimos Dimitrios

    2005-06-01

    Unruptured cerebral arterial aneurysms most often remain asymptomatic, but they may cause headache or other symptoms or signs. We describe herewith a case of headache attributed to an unruptured internal carotid artery aneurysm, clearly mimicking the phenotype of hemicrania continua. Potential pathophysiological explanations and recommendations for recognition of similar cases are discussed.

  18. Organic diseases mimicking acral lick dermatitis in six dogs.

    PubMed

    Denerolle, Philippe; White, Stephen D; Taylor, Tara S; Vandenabeele, Sophie I J

    2007-01-01

    Acral lick dermatitis ("lick granuloma") in dogs is often thought to have a behavioral etiology. However, other diseases may cause lesions on the distal legs, mimicking acral lick dermatitis. In this report, six dogs were presented with acral lick dermatitis-like lesions from different underlying causes-namely lymphoma, an orthopedic pin, deep pyoderma, mast cell tumor, leishmaniasis, and (presumptive) sporotrichosis.

  19. Rectal diverticulitis mimicking rectal carcinoma with intestinal obstruction: case report.

    PubMed

    Özçelik, Ümit; Bircan, Hüseyin Yüce; Eren, Eryiğit; Demiralay, Ebru; Işıklar, İclal; Demirağ, Alp; Moray, Gökhan

    2015-01-01

    Although diverticular disease of the colon is common, the occurrence of rectal diverticula is extremely rare with only sporadic reports in the literature since 1911. Symptomatic rectal diverticula are seen even less frequently, and surgical intervention is needed for only complicated cases. Here we report the case of a 63-year-old woman presenting with rectal diverticulitis mimicking rectal carcinoma with intestinal obstruction.

  20. Trichophyton Schoenleinii-induced widespread tinea corporis mimicking parapsoriasis.

    PubMed

    Mansouri, P; Farshi, S; Khosravi, A R; Naraghi, Z S; Chalangari, R

    2012-06-01

    We report a case of extensive tinea corporis in an 80-year-old woman on her forearms, thighs, legs, buttocks and trunk, mimicking parapsoriasis due to Trichophyton schoenleinii, without scalp involvement. Diagnosis of Trichophyton schoenleinii was confirmed by microscopy and mycological culture specimens.

  1. Retroperitoneal bronchogenic cyst mimicking hydatid liver: a case report.

    PubMed

    Parray, Fazl Q; Sherwani, Afak Yusuf; Dangroo, Sajad Ahmad; Bisati, Rafia Aziz; Malik, Nighat Shaffi

    2012-01-01

    Bronchogenic cysts frequently occur in the mediastinum. They may be rarely encountered in the abdomen and retroperitoneum. Bronchogenic cysts can in fact mimic hydatid cysts. We report a case of retroperitoneal bronchogenic cyst below the right hemidiaphragm mimicking a hydatid cyst of the liver in a 30-year-old female.

  2. Retroperitoneal Bronchogenic Cyst Mimicking Hydatid Liver: A Case Report

    PubMed Central

    Parray, Fazl Q.; Sherwani, Afak Yusuf; Dangroo, Sajad Ahmad; Bisati, Rafia Aziz; Malik, Nighat Shaffi

    2012-01-01

    Bronchogenic cysts frequently occur in the mediastinum. They may be rarely encountered in the abdomen and retroperitoneum. Bronchogenic cysts can in fact mimic hydatid cysts. We report a case of retroperitoneal bronchogenic cyst below the right hemidiaphragm mimicking a hydatid cyst of the liver in a 30-year-old female. PMID:22606600

  3. Cutaneous lymphoid hyperplasia mimicking cutaneous lymphoma in a hyperthyroid cat

    PubMed Central

    Snead, Elisabeth; Kerr, Moira; MacDonald, Valerie

    2013-01-01

    A 12-year-old neutered male domestic shorthair cat presented for chronic, localized, swelling and crusting of the left upper lip, weight loss, sporadic vomiting, and focal alopecia between the scapulae was diagnosed with hyperthyroidism and regional eosinophilic lymphadenitis. Treatment with methimazole exacerbated an underlying hypersensitivity disorder leading to marked generalized lymphadenopathy that histologically mimicked lymphoma. PMID:24155419

  4. Bronchial Aneurysms Mimicking Aortic Aneurysms: Endovascular Treatment in Two Patients

    SciTech Connect

    Vernhet, Helene; Bousquet, Claudine; Jean, Betty; Lesnik, Alvian; Durand, Gerard; Giron, Jacques; Senac, Jean Paul

    1999-05-15

    Bronchial artery dilatation and aneurysm formation is a potential complication of local inflammation, especially in bronchiectasis. When the bronchial artery has an ectopic origin from the inferior segment of the aortic arch, aneurysms may mimick aortic aneurysms. Despite this particular location, endovascular treatment is possible. We report two such aneurysms that were successfully embolized with steel coils.

  5. Giant cell myocarditis mimicking idiopathic fascicular ventricular tachycardia.

    PubMed

    Weidenbach, Michael; Springer, Tina; Daehnert, Ingo; Klingel, Karin; Doll, Susanne; Janousek, Jan

    2008-02-01

    We report an adolescent with giant cell myocarditis (GCM) mimicking tachycardia-induced cardiomyopathy. His electrocardiogram (ECG) was typical for an incessant form of fascicular ventricular tachycardia. The patient rapidly deteriorated and required support using extracorporeal membrane oxygenation (ECMO). Biopsy revealed GCM with massive myocyte necrosis. He was successfully heart transplanted 6 days after admission.

  6. Diffuse Large B Cell Lymphoma Mimicking Granulomatosis with Polyangiitis

    PubMed Central

    Horowitz, Netanel; Ben-Itzhak, Ofer; Braun-Moscovici, Yolanda

    2016-01-01

    In a patient with systemic multiorgan disease with overlapping features, the differential diagnosis included infectious diseases, malignancies, and systemic autoimmune or inflammatory diseases. We present an unusual case of a young male with B cell lymphoma who presented with symptoms mimicking systemic vasculitis and review the existing literature. PMID:27293945

  7. Fertilizer Emission Scenario Tool for crop management system scenarios

    EPA Pesticide Factsheets

    The Fertilizer Emission Scenario Tool for CMAQ is a high-end computer interface that simulates daily fertilizer application information for any gridded domain. It integrates the Weather Research and Forecasting model and CMAQ.

  8. Alternative scenarios utilizing nonterrestrial resources

    NASA Technical Reports Server (NTRS)

    Eldred, Charles H.; Roberts, Barney B.

    1992-01-01

    A collection of alternative scenarios that are enabled or substantially enhanced by the utilization of nonterrestrial resources is provided. We take a generalized approach to scenario building so that our report will have value in the context of whatever goals are eventually chosen. Some of the topics covered include the following: lunar materials processing; asteroid mining; lunar resources; construction of a large solar power station; solar dynamic power for the space station; reduced gravity; mission characteristics and options; and tourism.

  9. Scenario-based tsunami risk assessment using a static flooding approach and high-resolution digital elevation data: An example from Muscat in Oman

    NASA Astrophysics Data System (ADS)

    Schneider, Bastian; Hoffmann, Gösta; Reicherter, Klaus

    2016-04-01

    Knowledge of tsunami risk and vulnerability is essential to establish a well-adapted Multi Hazard Early Warning System, land-use planning and emergency management. As the tsunami risk for the coastline of Oman is still under discussion and remains enigmatic, various scenarios based on historical tsunamis were created. The suggested inundation and run-up heights were projected onto the modern infrastructural setting of the Muscat Capital Area. Furthermore, possible impacts of the worst-case tsunami event for Muscat are discussed. The approved Papathoma Tsunami Vulnerability Assessment Model was used to model the structural vulnerability of the infrastructure for a 2 m tsunami scenario, depicting the 1945 tsunami and a 5 m tsunami in Muscat. Considering structural vulnerability, the results suggest a minor tsunami risk for the 2 m tsunami scenario as the flooding is mainly confined to beaches and wadis. Especially traditional brick buildings, still predominant in numerous rural suburbs, and a prevalently coast-parallel road network lead to an increased tsunami risk. In contrast, the 5 m tsunami scenario reveals extensively inundated areas and with up to 48% of the buildings flooded, and therefore consequently a significantly higher tsunami risk. We expect up to 60000 damaged buildings and up to 380000 residents directly affected in the Muscat Capital Area, accompanied with a significant loss of life and damage to vital infrastructure. The rapid urbanization processes in the Muscat Capital Area, predominantly in areas along the coast, in combination with infrastructural, demographic and economic growth will additionally increase the tsunami risk and therefore emphasizes the importance of tsunami risk assessment in Oman.

  10. Tsunami hazard potential for the equatorial southwestern Pacific atolls of Tokelau from scenario-based simulations

    NASA Astrophysics Data System (ADS)

    Orpin, Alan R.; Rickard, Graham J.; Gerring, Peter K.; Lamarche, Geoffroy

    2016-05-01

    Devastating tsunami over the last decade have significantly heightened awareness of the potential consequences and vulnerability of low-lying Pacific islands and coastal regions. Our appraisal of the potential tsunami hazard for the atolls of the Tokelau Islands is based on a tsunami source-propagation-inundation model using Gerris Flow Solver, adapted from the companion study by Lamarche et al. (2015) for the islands of Wallis and Futuna. We assess whether there is potential for tsunami flooding on any of the village islets from a selection of 14 earthquake-source experiments. These earthquake sources are primarily based on the largest Pacific earthquakes of Mw ≥ 8.1 since 1950 and other large credible sources of tsunami that may impact Tokelau. Earthquake-source location and moment magnitude are related to tsunami-wave amplitudes and tsunami flood depths simulated for each of the three atolls of Tokelau. This approach yields instructive results for a community advisory but is not intended to be fully deterministic. Rather, the underlying aim is to identify credible sources that present the greatest potential to trigger an emergency response. Results from our modelling show that wave fields are channelled by the bathymetry of the Pacific basin in such a way that the swathes of the highest waves sweep immediately northeast of the Tokelau Islands. Our limited simulations suggest that trans-Pacific tsunami from distant earthquake sources to the north of Tokelau pose the most significant inundation threat. In particular, our assumed worst-case scenario for the Kuril Trench generated maximum modelled-wave amplitudes in excess of 1 m, which may last a few hours and include several wave trains. Other sources can impact specific sectors of the atolls, particularly distant earthquakes from Chile and Peru, and regional earthquake sources to the south. Flooding is dependent on the wave orientation and direct alignment to the incoming tsunami. Our "worst-case" tsunami

  11. Granuloma inguinale mimicking as squamous cell carcinoma of penis

    PubMed Central

    Pilani, Abhishek; Vora, Rita; Anjaneyan, Gopikrishnan

    2014-01-01

    Granuloma inguinale (GI) is an acquired chronic, slowly progressive, mildly contagious disease of venereal origin, characterized by granulomatous ulceration of the genitalia and neighboring sites, with little or no tendency to spontaneous healing caused by Klebsiella (Calymmatobacterium) granulomatis. A 55-year-old male presented with fissured, foul smelling, fungating growth over prepuce with phimosis mimicking squamous cell carcinoma (SCC) without lymphadenopathy. It started with painless papulonodular showed pseudoepitheliomatous hyperplasia, infiltration in dermis, acanthosis and vacuolated macrophages suggestive of GI and not showing any histopathological features of SCC. Patient was successfully treated by giving cotrimoxazole twice a day for 21 days. Here, we presented a case of GI mimicking SCC of penis, which was diagnosed on basis of histopathology and treated with excision followed by medical therapy with cotrimoxazole. PMID:24958990

  12. Rational Design of Pathogen-Mimicking Amphiphilic Materials as Nanoadjuvants

    NASA Astrophysics Data System (ADS)

    Ulery, Bret D.; Petersen, Latrisha K.; Phanse, Yashdeep; Kong, Chang Sun; Broderick, Scott R.; Kumar, Devender; Ramer-Tait, Amanda E.; Carrillo-Conde, Brenda; Rajan, Krishna; Wannemuehler, Michael J.; Bellaire, Bryan H.; Metzger, Dennis W.; Narasimhan, Balaji

    2011-12-01

    An opportunity exists today for cross-cutting research utilizing advances in materials science, immunology, microbial pathogenesis, and computational analysis to effectively design the next generation of adjuvants and vaccines. This study integrates these advances into a bottom-up approach for the molecular design of nanoadjuvants capable of mimicking the immune response induced by a natural infection but without the toxic side effects. Biodegradable amphiphilic polyanhydrides possess the unique ability to mimic pathogens and pathogen associated molecular patterns with respect to persisting within and activating immune cells, respectively. The molecular properties responsible for the pathogen-mimicking abilities of these materials have been identified. The value of using polyanhydride nanovaccines was demonstrated by the induction of long-lived protection against a lethal challenge of Yersinia pestis following a single administration ten months earlier. This approach has the tantalizing potential to catalyze the development of next generation vaccines against diseases caused by emerging and re-emerging pathogens.

  13. A patient with plaque type morphea mimicking systemic lupus erythematosus.

    PubMed

    Wardhana; Datau, E A

    2015-04-01

    Morphea is an uncommon connective tissue disease with the most prominent feature being thickening or fibrosis of the dermal without internal organ involvement. It is also known as a part of localized scleroderma. Based on clinical presentation and depth of tissue involvement, morphea is classified into several forms, and about two thirds of adults with morphea have plaque type. Overproduction of collagen production by fibroblast is the cause of abnormality in morphea, and the hyperactivity mechanism of fibroblast is still unknown, although there are several mechanisms already proposed. Plaque type morphea is actually a benign and self limited. Plaque type morphea that mimicking systemic lupus erythematosus in clinical appearance, such as alopecia and oral mucosal ulcers, is uncommon. A case of plaque type morphea mimicking systemic lupus erythematosus in a 20 year old woman was discussed. The patient was treated with local and systemic immunosuppressant and antioxydant. The patient's condition is improved without any significant side effects.

  14. Medical Scenarios Relevant to Spaceflight

    NASA Technical Reports Server (NTRS)

    Bacal, Kira; Hurs, Victor; Doerr, Harold

    2004-01-01

    The Medical Operational Support Team (MOST) was tasked by the JSC Space Medicine and Life Sciences Directorate (SLSD) to incorporate medical simulation into 1) medical training for astronaut-crew medical officers (CMO) and medical flight control teams and 2) evaluations of procedures and resources required for medical care aboard the International Space Station (ISS). Development of evidence-based medical scenarios that mimic the physiology observed during spaceflight will be needed for the MOST to complete these two tasks. The MOST used a human patient simulator, the ISS-like resources in the Medical Simulation Laboratory (MSL), and evidence from space operations, military operations and medical literature to develop space relevant medical scenarios. These scenarios include conditions concerning airway management, Advanced Cardiac Life Support (ACLS) and mitigating anaphylactic symptoms. The MOST has used these space relevant medical scenarios to develop a preliminary space medical training regimen for NASA flight surgeons, Biomedical Flight Controllers (Biomedical Engineers; BME) and CMO-analogs. This regimen is conducted by the MOST in the MSL. The MOST has the capability to develop evidence-based space-relevant medical scenarios that can help SLSD I) demonstrate the proficiency of medical flight control teams to mitigate space-relevant medical events and 2) validate nextgeneration medical equipment and procedures for space medicine applications.

  15. Reactive arthritis mimicking inflammatory bowel disease arthritis: a challenging diagnosis.

    PubMed

    Trabulo, D; Mangualde, J; Cremers, I; Oliveira, A P

    2014-01-01

    Reactive arthritis comprises a subgroup of infection-associated arthritis which occurs after genitourinary or gastrointestinal tract infection in genetically susceptible hosts. Studies have proposed Salmonella, Shigella or Yersinia infection as the microorganisms responsible for the post-dysenteric form. The human leukocyte antigen (HLA)-B27 is a well recognised best-known predisposing factor. We report a case of HLA-B27-associated reactive arthritis after Salmonella goldcoast enteritis, mimicking inflammatory bowel disease arthritis.

  16. Testicular Schistosomiasis Mimicking Malignancy in a Child: A Case Report.

    PubMed

    Ekenze, Sebastian O; Modekwe, Victor O; Nzegwu, Martin A; Ekpemo, Samuel C; Ezomike, Uchechukwu O

    2015-08-01

    Schistosomiasis is an important communicable disease in the developing world. However, testicular schistosomiasis is an extremely rare condition. We report a case of testicular schistosomiasis mimicking testicular tumour in a 13 year old who presented with huge unilateral testicular mass. The dilemma encountered in the diagnosis and treatment of this child is presented to highlight the need for high index of suspicion of this pathology in children with testicular mass presenting from schistosomiasis-endemic areas.

  17. Osteofibrous dysplasia of clavicle clinically mimicking chronic osteomyelitis

    PubMed Central

    Gopinathan, Nirmal Raj; Prakash, Mahesh; Saibaba, Balaji; Das, Ashim

    2016-01-01

    Osteofibrous dysplasia or ossifying fibroma is an uncommon benign fibro-osseous lesion of childhood, commonly described in the maxilla and the mandible. Among long bones, it usually presents in the tibia as a painless swelling or anterior bowing. Ossifying fibroma of clavicle has never been reported in English literature, to the best of our knowledge. Here, we would like to present an unusual case of osteofibrous dysplasia of clavicle clinically mimicking chronic osteomyelitis. PMID:27413281

  18. Cartilage Delamination Flap Mimicking a Torn Medial Meniscus

    PubMed Central

    Bin Abd Razak, Hamid Rahmatullah; Amit Kanta, Mitra

    2016-01-01

    We report a case of a chondral delamination lesion due to medial parapatellar plica friction syndrome involving the medial femoral condyle. This mimicked a torn medial meniscus in clinical and radiological presentation. Arthroscopy revealed a chondral delamination flap, which was debrided. Diagnosis of chondral lesions in the knee can be challenging. Clinical examination and MRI have good accuracy for diagnosis and should be used in tandem. Early diagnosis and treatment of chondral lesions are important to prevent progression to early osteoarthritis. PMID:28070434

  19. Mimicking biological functionality with polymers for biomedical applications

    NASA Astrophysics Data System (ADS)

    Green, Jordan J.; Elisseeff, Jennifer H.

    2016-12-01

    The vast opportunities for biomaterials design and functionality enabled by mimicking nature continue to stretch the limits of imagination. As both biological understanding and engineering capabilities develop, more sophisticated biomedical materials can be synthesized that have multifaceted chemical, biological and physical characteristics designed to achieve specific therapeutic goals. Mimicry is being used in the design of polymers for biomedical applications that are required locally in tissues, systemically throughout the body, and at the interface with tissues.

  20. Intracranial subdural empyema mimicking a recurrent chronic subdural hematoma

    PubMed Central

    Doan, Ninh; Patel, Mohit; Nguyen, Ha Son; Mountoure, Andrew; Shabani, Saman; Gelsomino, Michael; Janich, Karl; Kurpad, Shekar

    2016-01-01

    Intracranial subdural empyema (ISDE) is a life-threatening condition. The risk for ISDE increases in patients that have undergone prior intracranial procedures. The non-specificity in its clinical presentation often makes ISDE difficult to diagnose. Here, we present a rare case of ISDE mimicking a recurrent chronic subdural hematoma, emphasizing the significance of obtaining early magnetic resonance images of the brain for early diagnosis and treatment to achieve the optimal outcome. PMID:27651110

  1. Localized IgG4-related Cholecystitis Mimicking Gallbladder Cancer.

    PubMed

    Inoue, Tadahisa; Okumura, Fumihiro; Mizushima, Takashi; Nishie, Hirotada; Iwasaki, Hiroyasu; Anbe, Kaiki; Ozeki, Takanori; Kachi, Kenta; Fukusada, Shigeki; Suzuki, Yuta; Watanabe, Kazuko; Sano, Hitoshi

    2015-01-01

    We encountered a case of localized IgG4-cholecystitis mimicking gallbladder cancer with focal/segmental type1 autoimmune pancreatitis (AIP). In this case, we were unable to exclude a diagnosis of gallbladder cancer and thus performed radical cholecystectomy. Type1 AIP is often associated with gallbladder lesions, accompanied by generally diffuse, circumferential thickening of the gallbladder wall. Although localized IgG4-related cholecystitis is extremely rare, differentiating this condition from gallbladder cancer is often very difficult.

  2. A giant ancient schwannoma mimicking an adnexal mass

    PubMed Central

    Karaköse, Oktay; Pülat, Hüseyin; Oğuz, Serhat; Zihni, İsmail; Özçelik, Kazım Çağlar; Yalta, Tülin Deniz; Eken, Hüseyin

    2016-01-01

    Abstract Introduction: Ancient schwannoma is a rare tumor of the peripheral nerve sheath. As degenerative properties are defined histologically, it can be wrongly interpreted as malignant. Case presentation: The case presented here is of a giant ancient schwannoma with a pelvic retroperitoneal location, which was mimicking an adnexal mass. Conclusion: In the rarely seen cases in the retroperitoneum, it may reach very large dimensions. PMID:27472696

  3. Regional bone change in intramuscular haemangioma mimicking primary bone tumour.

    PubMed

    Shikhare, Sumer; Chacko, Julio K; Chuah, Khoon L

    2015-04-01

    Intramuscular haemangiomas are benign soft-tissue tumours, commonly located in the extremities. We present a right-leg intramuscular haemangioma with florid periosteal reaction in adjacent tibia, mimicking a primary bone tumour. Plain radiograph and magnetic resonance imaging features are illustrated with the surgical and histopathological findings. Radiologists need to be familiar with reactive bone changes secondary to deep-seated intramuscular haemangiomas to avoid potential misdiagnosis.

  4. Beyond Worst-Case Analysis in Privacy and Clustering: Exploiting Explicit and Implicit Assumptions

    DTIC Science & Technology

    2013-08-01

    the Netflix prize compe- 46 tition) defines neighboring databases as a change in a single entry, and introduces O(k2) noise while outputting a rank-k...9.1.1, 9.2.2, 9.1, 9.5, 9.5 [111] Frank McSherry and Ilya Mironov. Differentially private recommender systems: Building privacy into the netflix prize

  5. The year-long unprecedented European heat and drought of 1540 - a worst case

    NASA Astrophysics Data System (ADS)

    Wetter, Oliver

    2015-04-01

    The heat waves of 2003 in Western Europe and 2010 in Russia, commonly labelled as rare climatic anomalies outside of previous experience, are often taken as harbingers of more frequent extremes in the global warming-influenced future. However, a recent reconstruction of spring-summer temperatures for WE resulted in the likelihood of significantly higher temperatures in 1540. In order to check the plausibility of this result we investigated the severity of the 1540 drought by putting forward the argument of the known soil desiccation-temperature feedback. Based on more than 300 first-hand documentary weather report sources originating from an area of 2 to 3 million km2, we show that Europe was affected by an unprecedented 11-month-long Megadrought. The estimated number of precipitation days and precipitation amount for Central and Western Europe in 1540 is significantly lower than the 100-year minima of the instrumental measurement period for spring, summer and autumn. This result is supported by independent documentary evidence about extremely low river flows and Europe-wide wild-, forestand settlement fires. We found that an event of this severity cannot be simulated by state-of-the-art climate models.

  6. Modeling Mission-Specific Worst-Case Solar Energetic Particle Environments

    NASA Technical Reports Server (NTRS)

    Adam, James H., Jr.; Dietrich, William F.; Xapsos, Michael A.

    2011-01-01

    To plan and design safe and reliable space missions, it is necessary to take into account the effects of the space radiation environment. The environment during large solar energetic particle events poses the greatest challenge to missions. As a starting point for planning and design, a reference environment must be specified representing the most challenging environment to be encountered during the mission at some confidence level. The engineering challenge is then to find plans and mission design solutions that insure safe and reliable operations in this reference environment. This paper describes progress toward developing a model that provides such reference space radiation environments at user-specified confidence levels.

  7. Evaluation of Bias Correction Methods for "Worst-case" Selective Non-participation in NAEP

    ERIC Educational Resources Information Center

    McLaughlin, Don; Gallagher, Larry; Stancavage, Fran

    2004-01-01

    With the advent of No Child Left Behind (NCLB), the context for NAEP participation is changing. Whereas in the past participation in NAEP has always been voluntary, participation is now mandatory for some grade and subjects among schools receiving Title I funds. While this will certainly raise school-level participation rates in the mandated…

  8. Heparin-Mimicking Polymers: Synthesis and Biological Applications

    PubMed Central

    2016-01-01

    Heparin is a naturally occurring, highly sulfated polysaccharide that plays a critical role in a range of different biological processes. Therapeutically, it is mostly commonly used as an injectable solution as an anticoagulant for a variety of indications, although it has also been employed in other forms such as coatings on various biomedical devices. Due to the diverse functions of this polysaccharide in the body, including anticoagulation, tissue regeneration, anti-inflammation, and protein stabilization, and drawbacks of its use, analogous heparin-mimicking materials are also widely studied for therapeutic applications. This review focuses on one type of these materials, namely, synthetic heparin-mimicking polymers. Utilization of these polymers provides significant benefits compared to heparin, including enhancing therapeutic efficacy and reducing side effects as a result of fine-tuning heparin-binding motifs and other molecular characteristics. The major types of the various polymers are summarized, as well as their applications. Because development of a broader range of heparin-mimicking materials would further expand the impact of these polymers in the treatment of various diseases, future directions are also discussed. PMID:27739666

  9. Alternative Geothermal Power Production Scenarios

    DOE Data Explorer

    Sullivan, John

    2014-03-14

    The information given in this file pertains to Argonne LCAs of the plant cycle stage for a set of ten new geothermal scenario pairs, each comprised of a reference and improved case. These analyses were conducted to compare environmental performances among the scenarios and cases. The types of plants evaluated are hydrothermal binary and flash and Enhanced Geothermal Systems (EGS) binary and flash plants. Each scenario pair was developed by the LCOE group using GETEM as a way to identify plant operational and resource combinations that could reduce geothermal power plant LCOE values. Based on the specified plant and well field characteristics (plant type, capacity, capacity factor and lifetime, and well numbers and depths) for each case of each pair, Argonne generated a corresponding set of material to power ratios (MPRs) and greenhouse gas and fossil energy ratios.

  10. Haunted Quantum Entanglement: Two Scenarios

    NASA Astrophysics Data System (ADS)

    Snyder, Douglas

    2010-04-01

    Two haunted quantum entanglement scenarios are proposed that are very close to the haunted measurement scenario in that: 1) the entity that is developing as a which-way marker is effectively restored to its state prior to its being fixed as a w-w marker, and 2) the entity for which the developing w-w marker provides information is restored to its state before it interacted with the entity which subsequent to the interaction begins developing as a w-w marker. In the hqe scenarios, the loss of developing w-w information through 1 relies on the loss of a developing entanglement. In scenario 1, the photon initially emitted in one of two micromaser cavities and developing into a w-w marker is effectively lost through the injection of classical microwave radiation into both of the microwave cavities after the atom initially emits the photon into one of the micromaser cavities, exits the cavity system, and before this atom reaches the 2 slit screen. The atom is restored in both of the two new scenarios to its original state before it emitted a photon by an rf coil situated at the exit of the micromaser cavity system. In scenario 2, the cavity system and everything from the atom source forward to the cavity system is enclosed in an evacuated box. After the atom that emits the photon exits the cavity system and before it reaches the 2 slit screen, the cavity system opens (and the photon escapes in the evacuated box) and then the box is opened and the photon escapes into the environment.

  11. Modelling regional climate change and urban planning scenarios and their impacts on the urban environment in two cities with WRF-ACASA

    NASA Astrophysics Data System (ADS)

    Falk, M.; Pyles, R. D.; Marras, S.; Spano, D.; Paw U, K. T.

    2011-12-01

    The number of urban metabolism studies has increased in recent years, due to the important impact that energy, water and carbon exchange over urban areas have on climate change. Urban modeling is therefore crucial in the future design and management of cities. This study presents the ACASA model coupled to the Weather Research and Forecasting (WRF-ARW) mesoscale model to simulate urban fluxes at a horizontal resolution of 200 meters for urban areas of roughly 100 km^2. As part of the European Project "BRIDGE", these regional simulations were used in combination with remotely sensed data to provide constraints on the land surface types and the exchange of carbon and energy fluxes from urban centers. Surface-atmosphere exchanges of mass and energy were simulated using the Advanced Canopy Atmosphere Soil Algorithm (ACASA). ACASA is a multi-layer high-order closure model, recently modified to work over natural, agricultural as well as urban environments. In particular, improvements were made to account for the anthropogenic contribution to heat and carbon production. For two cities four climate change and four urban planning scenarios were simulated: The climate change scenarios include a base scenario (Sc0: 2008 Commit in IPCC), a medium emission scenario (Sc1: IPCC A2), a worst case emission scenario (Sce2: IPCC A1F1) and finally a best case emission scenario (Sce3: IPCC B1). The urban planning scenarios include different development scenarios such as smart growth. The two cities are a high latitude city, Helsinki (Finland) and an historic city, Florence (Italy). Helsinki is characterized by recent, rapid urbanization that requires a substantial amount of energy for heating, while Florence is representative of cities in lower latitudes, with substantial cultural heritage and a comparatively constant architectural footprint over time. In general, simulated fluxes matched the point observations well and showed consistent improvement in the energy partitioning over

  12. Ultra-Perfect Sorting Scenarios

    NASA Astrophysics Data System (ADS)

    Ouangraoua, Aïda; Bergeron, Anne; Swenson, Krister M.

    Perfection has been used as a criteria to select rearrangement scenarios since 2004. However, there is a fundamental bias towards extant species in the original definition: ancestral species are not bound to perfection. Here we develop a new theory of perfection that takes an egalitarian view of species, and apply it to the complex evolution of mammal chromosome X.

  13. Future Scenarios and Environmental Education

    ERIC Educational Resources Information Center

    Kopnina, Helen

    2014-01-01

    This article explores a number of questions about visions of the future and their implications for environmental education (EE). If the future were known, what kind of actions would be needed to maintain the positive aspects and reverse the negative ones? How could these actions be translated into the aims of EE? Three future scenarios are…

  14. Space resources. Volume 1: Scenarios

    NASA Technical Reports Server (NTRS)

    Mckay, Mary Fae (Editor); Mckay, David S. (Editor); Duke, Michael B. (Editor)

    1992-01-01

    A number of possible future paths for space exploration and development are presented. The topics covered include the following: (1) the baseline program; (2) alternative scenarios utilizing nonterrestrial resources; (3) impacts of sociopolitical conditions; (4) common technologies; and issues for further study.

  15. Particle production in Ekpyrotic scenarios

    SciTech Connect

    Hipólito-Ricaldi, W.S.; Brandenberger, Robert; Ferreira, Elisa G.M.; Graef, L.L.

    2016-11-09

    We consider Parker particle production in the Ekpyrotic scenario (in particular in the New Ekpyrotic model) and show that the density of particles produced by the end of the phase of Ekpyrotic contraction can be sufficient to lead to a hot state of matter after the bounce. Hence, no separate reheating mechanism is necessary.

  16. Theoretical assessment of the maximum obtainable power in wireless power transfer constrained by human body exposure limits in a typical room scenario.

    PubMed

    Chen, Xi Lin; De Santis, Valerio; Umenei, Aghuinyue Esai

    2014-07-07

    In this study, the maximum received power obtainable through wireless power transfer (WPT) by a small receiver (Rx) coil from a relatively large transmitter (Tx) coil is numerically estimated in the frequency range from 100 kHz to 10 MHz based on human body exposure limits. Analytical calculations were first conducted to determine the worst-case coupling between a homogeneous cylindrical phantom with a radius of 0.65 m and a Tx coil positioned 0.1 m away with the radius ranging from 0.25 to 2.5 m. Subsequently, three high-resolution anatomical models were employed to compute the peak induced field intensities with respect to various Tx coil locations and dimensions. Based on the computational results, scaling factors which correlate the cylindrical phantom and anatomical model results were derived. Next, the optimal operating frequency, at which the highest transmitter source power can be utilized without exceeding the exposure limits, is found to be around 2 MHz. Finally, a formulation is proposed to estimate the maximum obtainable power of WPT in a typical room scenario while adhering to the human body exposure compliance mandates.

  17. Various Tumor-Mimicking Lesions in the Musculoskeletal System: Causes and Diagnostic Approach

    PubMed Central

    Kim, Sue Yon; Ryu, Kyung Nam; Jin, Wook; Park, So Young

    2011-01-01

    Tumor-mimicking lesions in the musculoskeletal system can be defined as lesions mistaken as tumors due to the presence of palpation upon physical examination or a tumor-like appearance upon radiological examination. Moreover, tumor-mimicking lesions show diverse etiologies and anatomic locations. We illustrated the various tumor-mimicking lesions involving bone and soft tissue. In this review, the tumor-mimicking lesions were classified into those based on clinical examination and those based on radiological examination in musculoskeletal radiology. Awareness of the various causes of tumor-mimicking lesions, correctly obtaining clinical information, and the proper selection of imaging modality are important for the differentiation of tumor-mimicking lesions from true neoplasms. PMID:21430940

  18. Exploring NASA Human Spaceflight and Pioneering Scenarios

    NASA Technical Reports Server (NTRS)

    Zapata, Edgar; Wilhite, Alan

    2015-01-01

    The life cycle cost analysis of space exploration scenarios is explored via a merger of (1) scenario planning, separating context and (2) modeling and analysis of specific content. Numerous scenarios are presented, leading to cross-cutting recommendations addressing life cycle costs, productivity, and approaches applicable to any scenarios. Approaches address technical and non-technical factors.

  19. Subcutaneous Phaeohyphomycosis Due to Pyrenochaeta romeroi Mimicking a Synovial Cyst

    PubMed Central

    Dinh, Aurélien; Levy, Bruno; Bouchand, Frédérique; Davido, Benjamin; Duran, Clara; Cristi, Marin; Felter, Adrien; Salomon, Jérôme; Ait Ammar, Nawel

    2016-01-01

    Opportunistic subcutaneous fungal infections are increasing nowadays due to the growing number of medical conditions causing immunosuppression, especially organ transplant. The incidence rate of subcutaneous phaeohyphomycosis is very low. Most studies found are case reports. They showed a wide variation of clinical presentations. Pyrenochaeta romeroi, a fungus from the Dematiaceae group is a saprophyte found in soil and plants and a possible causative agent of phaeohyphomycosis. We present a rare case of subcutaneous phaeohyphomycosis caused by P. romeroi mimicking a synovial cyst in a diabetic patient. PMID:27630637

  20. Hepatitis A infection mimicking adult onset Still's disease.

    PubMed

    Sridharan, S; Mossad, S; Hoffman, G

    2000-07-01

    Fever, rash, and arthritis may be components of the prodrome of viral hepatitis. In the absence of jaundice and abnormal liver function tests, this form of polyarthritis is easily confused with primary autoimmune diseases. Whereas the association of systemic illness with musculoskeletal symptoms and numerous viral infections is well known, such an association with hepatitis A has only been rarely reported. We describe a case of hepatitis A infection mimicking adult onset Still's disease, and review the pathogenesis and differential diagnosis of Still's disease and the extraarticular manifestations of hepatitis.

  1. A case of generalized ostraceous psoriasis mimicking dermatitis neglecta.

    PubMed

    Nascimento, Bianca Angelina Macêdo do; Carvalho, Alessandra Haber; Dias, Carolina Moraes; Lage, Thaiane Lima; Carneiro, Clívia Maria Oliveira; Bittencourt, Maraya de Jesus Semblano

    2015-01-01

    Lithium has been implicated in the exacerbation of pre-existing psoriasis, in the induction of psoriasis on previously uninvolved skin of psoriasis patients, and in the triggering of psoriasis for the first time in patients without a personal or family history. Lithium-induced psoriasis (and its resistance to treatment) is one of the major reasons for noncompliance in patients treated with lithium. We describe a male patient who developed generalized ostraceous psoriasis whose clinical appearance mimicked dermatitis neglecta, 10 months after starting therapy with lithium.

  2. Superficial Fibromatosis Mimicking Glomus Tumor of the Second Toe

    PubMed Central

    Jo, Hyang Jeong; Kim, Gang Deuk; Kim, Yeung Jin; Choi, Deok Hwa; Park, Jae In

    2015-01-01

    Various types of tumor can occur in the subungual space, including glomus tumors, subungual exostosis, hemangioma, epidermal cysts, and malignant tumors. While fibromatosis can occur at various sites throughout the body, it is very rarely seen in the toe. Here, we are the first to report a case of superficial fibromatosis mimicking a glomus tumor in the subungual space of the second toe. The presentation of this condition shows the possibility of encountering uncommon superficial fibromatosis in the distal phalanx of the toe, and suggests that superficial fibromatosis should be included in the differential diagnosis of a glomus tumor in the toe. PMID:26330970

  3. Simple bone cyst of mandible mimicking periapical cyst.

    PubMed

    Hs, Charan Babu; Rai, Bhagawan Das; Nair, Manju A; Astekar, Madhusudan S

    2012-05-29

    Simple bone cysts (SBC) are pseudocysts occurring less commonly in the maxillofacial region. The uncertain and unclear etiopathogenesis led to numerous synonyms to refer this particular cyst. These cysts are devoid of an epithelial lining and are usually empty or contain blood or straw-colored fluid. In jaws initially it mimics a periapical cyst and later can lead to cortical bone expansion warranting for radical approach, which is seldom required. SBC is predominantly diagnosed in first two decades of life. Here we report a case of solitary bone cyst mimicking a periapical cyst of a mandibular molar in a 37-year-old patient.

  4. Brucellosis mimicking Henoch-Schönlein purpura.

    PubMed

    Massasso, David; Gibson, Kathryn

    2007-06-04

    A young male immigrant from Syria with a vasculitic-appearing leg rash, asymmetrical polyarthritis, microscopic haematuria, and raised inflammatory markers was provisionally diagnosed with Henoch-Schönlein purpura. Skin biopsy showed leukocytoclastic vasculitis. Low-grade fevers persisted despite non-steroidal anti-inflammatory therapy, and Brucella sp. was subsequently grown from both blood and synovial fluid aspirates. Further tests gave positive results for B. abortus, and triple antibiotic therapy produced a rapid clinical response. Cutaneous vasculitis has rarely been described in brucellosis, and this is the first report in the English medical literature of brucellosis mimicking Henoch-Schönlein purpura.

  5. Iliacus pyomyositis mimicking septic arthritis of the hip joint.

    PubMed

    Chen W-S; Wan Y-L

    1996-01-01

    The iliacus muscle is closely associated with the psoas muscle, femoral nerve, hip joint, pelvic and intraabdominal structures; thus, its disorders may present as lower abdominal pain, hip pain, or femoral neuropathy. Iliacus pyomyositis, a primary bacterial infection of the skeletal muscle not secondary to a contiguous skin, bone, or soft-tissue infection, presenting as hip pain, femoral neuropathy, and sympathetic effusion of the hip joint in an 8-year-old boy mimicked septic arthritis of the hip joint. Computed tomography was helpful in delineating the accurate location of the lesion. Surgical drainage and appropriate antibiotic therapy led to complete resolution and full functional recovery.

  6. Klebsiella pneumoniae pharyngitis mimicking malignancy: a diagnostic dilemma.

    PubMed

    Yeh, C-F; Li, W-Y; Hsu, Y-B

    2014-12-01

    Acute pharyngitis is a common disease. However, acute pharyngitis caused by Klebsiella pneumoniae with a gross appearance mimicking hypopharyngeal malignancy has never previously been reported. We report the case of a 57-year-old man with a right hypopharyngeal tumor which was disclosed by fiberoptic laryngoscopy and computed tomography scan. However, both the frozen and final pathologies showed no evidence of malignant cells, and a bacterial culture revealed the growth of K. pneumoniae. The hypopharyngeal lesion completely regressed after 2 weeks of antibiotic treatment. Clinicians should perform biopsy along with tissue culture for tumor-like lesions because infectious agents can lead to lesions with malignancy-like appearance.

  7. Intimal Sarcoma of the Descending Aorta Mimicking Aortitis

    PubMed Central

    Pucci, Angela; De Martino, Andrea; Levantino, Maurizio; Berchiolli, Raffaella; Basolo, Fulvio; Bortolotti, Uberto

    2016-01-01

    We describe a 74-year-old male patient with an intimal sarcoma of the descending aorta mimicking aortitis. The patient presented with lower back pain, fever, and increased C-reactive protein, erythrocyte sedimentation rate, and immunoglobulin G4 (IgG4) serum levels, together with Staphylococcus epidermidis-positive blood cultures. These findings, together with evidence of a 49-mm pseudoaneurysm of the descending thoracic aorta, caused us to suspect aortitis. However, postoperative histology and immunohistochemistry demonstrated the presence of an intimal aortic sarcoma. At the 8-month follow-up, local recurrence of the neoplasm and lung metastases were noted. PMID:28097198

  8. Subarachnoid haemorrhage mimicking transient ST-segment elevation myocardial infarction.

    PubMed

    Lai, C-H; Juan, Y-H; Chang, S-L; Lee, W-L; How, C-K; Hsu, T-F

    2015-08-01

    Patients often present to the emergency department with loss of consciousness. The differential diagnosis of such condition may be difficult because of limited clinical information. The authors present a case of subarachnoid haemorrhage (SAH) with initial electrocardiographic (ECG) finding mimicking ST-segment elevation myocardial infarction (STEMI), which was confirmed to resolve in a follow-up study. Accurate and timely diagnosis of SAH-related ST-segment elevation was important, as the therapeutic strategy for SAH is completely different from that for STEMI. If the clinicians do not have other tools for diagnosis, the follow-up ECG may help us make a most possible diagnosis.

  9. Endometriosis after surgical menopause mimicking pelvic malignancy: surgeons' predicament.

    PubMed

    Bhat, Rani A; Teo, Melissa; Bhat, Akhil Krishnanand

    2014-05-01

    Prevalence of persistent endometriosis in women after menopause without any hormonal replacement therapy is very rare. This is a case of a woman with previous history of total hysterectomy and bilateral salpingo-oophorectomy for endometriosis who presented with hemoperitoneum, vaginal bleeding, pelvic mass, and pulmonary thromboembolism mimicking as rectovaginal septum carcinoma. This is the first case report with a unique mode of presentation wherein the patient presented with hemoperitoneum requiring emergency embolization of the vessel to stabilize the patient. She underwent en bloc resection of the tumor with high anterior resection of the rectum. Histopathology confirmed endometriosis.

  10. Endometriosis After Surgical Menopause Mimicking Pelvic Malignancy: Surgeons’ Predicament

    PubMed Central

    Bhat, Rani A.; Teo, Melissa; Bhat, Akhil Krishnanand

    2014-01-01

    Prevalence of persistent endometriosis in women after menopause without any hormonal replacement therapy is very rare. This is a case of a woman with previous history of total hysterectomy and bilateral salpingo-oophorectomy for endometriosis who presented with hemoperitoneum, vaginal bleeding, pelvic mass, and pulmonary thromboembolism mimicking as rectovaginal septum carcinoma. This is the first case report with a unique mode of presentation wherein the patient presented with hemoperitoneum requiring emergency embolization of the vessel to stabilize the patient. She underwent en bloc resection of the tumor with high anterior resection of the rectum. Histopathology confirmed endometriosis. PMID:24936277

  11. A case of generalized ostraceous psoriasis mimicking dermatitis neglecta*

    PubMed Central

    do Nascimento, Bianca Angelina Macêdo; Carvalho, Alessandra Haber; Dias, Carolina Moraes; Lage, Thaiane Lima; Carneiro, Clívia Maria Oliveira; Bittencourt, Maraya de Jesus Semblano

    2015-01-01

    Lithium has been implicated in the exacerbation of pre-existing psoriasis, in the induction of psoriasis on previously uninvolved skin of psoriasis patients, and in the triggering of psoriasis for the first time in patients without a personal or family history. Lithium-induced psoriasis (and its resistance to treatment) is one of the major reasons for noncompliance in patients treated with lithium. We describe a male patient who developed generalized ostraceous psoriasis whose clinical appearance mimicked dermatitis neglecta, 10 months after starting therapy with lithium. PMID:26312715

  12. Fundamental Study of Bone-Mimicking Phantom Using Apatite

    NASA Astrophysics Data System (ADS)

    Hirai, Takuya; Ohdaira, Etsuzo; Masuzawa, Nobuyoshi; Itoh, Katsuhiko; Matozaki, Takeshi

    2001-05-01

    Because of the success of the ultrasonic method for diagnosing osteoporosis, the challenge to obtain ultrasonic images of the inner part of bone has begun. Since ultrasonic imaging of the inner part of bone is very difficult, further research is necessary. The goal of this study is to develop a bone-mimicking phantom for use in the visualization of bone by ultrasound. The developed phantom using apatite and polyvinyl alcohol (PVA) as materials with consideration of the periosteum showed fairly good agreement with real bone.

  13. Subacute combined degeneration mimicking traumatic spinal cord injury.

    PubMed

    Paul, Ian; Reichard, R Ross

    2009-03-01

    Subacute combined degeneration (SCD) of the spinal cord is the most common neurologic manifestation of vitamin B12 (cobalamin) deficiency and is usually secondary to autoimmune gastritis, but may also be seen in malnutrition syndromes such as chronic alcoholism, strict vegetarianism, gastrectomy, and also in nitrous oxide abuse. Although traumatic spinal cord injury is routinely encountered in the medical examiner's office, medical causes of spinal cord abnormalities such as SCD should be considered in the appropriate clinical setting. We report a case of alcohol-associated SCD mimicking traumatic spinal cord injury.

  14. Giant submandibular gland duct sialolith mimicking an impacted canine tooth

    PubMed Central

    Bhullar, Ramandeep Singh; Dhawan, Amit; Bhullar, Kanwalpreet; Malhotra, Sonia

    2015-01-01

    Sialolithiasis is the most common disease affecting the salivary glands and accounts for 80% of salivary gland disorders. Chronic sialolithiasis promotes stone formation. Size of the salivary stones may range from 0.1 mm to 30 mm or be even bigger. Those salivary stones, the size of which exceeds 15 mm in any one dimension or 1 g in weight are classified as giant sialoliths. Giant sialoliths of the submandibular gland duct are rarely reported. Here, we report a case of a giant sialolith of the submandibular gland duct mimicking an impacted mandibular canine tooth on routine radiographic examination and its surgical management through an intraoral approach. PMID:26668461

  15. Tissue-Mimicking Materials Using Segmented Polyurethane Gel and Their Acoustic Properties

    NASA Astrophysics Data System (ADS)

    Yoshida, Tomoji; Tanaka, Kouhei; Kondo, Toshio; Yasukawa, Kazuhiro; Miyamoto, Nobuaki; Taniguchi, Masahiko; Shikinami, Yasuo

    2012-07-01

    Accurate testing of an instrument by phantoms requires a tissue-mimicking material that has the acoustic velocity and density defined in the International Electrotechnical Commission (IEC) standard, and furthermore the tissue-mimicking material must be stable over time. To achieve the tissue-mimicking materials with the desired acoustic velocity and density defined in the IEC standard, new materials have been developed. The form of tissue-mimicking materials reported comprised polystyrene and poly(methyl methacrylate) (PMMA) particles dispersed in segmented polyurethane gel. They were stable over a period of 40 days and the changes in weight and acoustic velocity did not exceed 0.5%.

  16. Designing Asteroid Impact Scenario Trajectories

    NASA Astrophysics Data System (ADS)

    Chodas, Paul

    2016-05-01

    In order to study some of the technical and geopolitical issues of dealing with an asteroid on impact trajectory, a number of hypothetical impact scenarios have been presented over the last ten years or so. These have been used, for example, at several of the Planetary Defense Conferences (PDCs), as well as in tabletop exercises with the Federal Emergency Management Agency (FEMA), along with other government agencies. The exercise at the 2015 PDC involved most of the attendees, consisted of seven distinct steps (“injects”), and with all the presentations and discussions, took up nearly 10 hours of conference time. The trajectory for the PDC15 scenario was entirely realistic, and was posted ahead of the meeting. It was made available in the NEO Program’s Horizons ephemeris service so that users could , for example, design their own deflection missions. The simulated asteroid and trajectory had to meet numerous very exacting requirements: becoming observable on the very first day of the conference, yet remaining very difficult to observe for the following 7 years, and far enough away from Earth that it was out of reach of radar until just before impact. It had to be undetectable in the past, and yet provide multiple perihelion opportunities for deflection in the future. It had to impact in a very specific region of the Earth, a specific number of years after discovery. When observations of the asteroid are simulated to generate an uncertainty region, that entire region must impact the Earth along an axis that cuts across specific regions of the Earth, the “risk corridor”. This is important because asteroid deflections generally move an asteroid impact point along this corridor. One scenario had a requirement that the asteroid pass through a keyhole several years before impact. The PDC15 scenario had an additional constraint that multiple simulated kinetic impactor missions altered the trajectory at a deflection point midway between discovery and impact

  17. Threatened species and the potential loss of phylogenetic diversity: conservation scenarios based on estimated extinction probabilities and phylogenetic risk analysis.

    PubMed

    Faith, Daniel P

    2008-12-01

    New species conservation strategies, including the EDGE of Existence (EDGE) program, have expanded threatened species assessments by integrating information about species' phylogenetic distinctiveness. Distinctiveness has been measured through simple scores that assign shared credit among species for evolutionary heritage represented by the deeper phylogenetic branches. A species with a high score combined with a high extinction probability receives high priority for conservation efforts. Simple hypothetical scenarios for phylogenetic trees and extinction probabilities demonstrate how such scoring approaches can provide inefficient priorities for conservation. An existing probabilistic framework derived from the phylogenetic diversity measure (PD) properly captures the idea of shared responsibility for the persistence of evolutionary history. It avoids static scores, takes into account the status of close relatives through their extinction probabilities, and allows for the necessary updating of priorities in light of changes in species threat status. A hypothetical phylogenetic tree illustrates how changes in extinction probabilities of one or more species translate into changes in expected PD. The probabilistic PD framework provided a range of strategies that moved beyond expected PD to better consider worst-case PD losses. In another example, risk aversion gave higher priority to a conservation program that provided a smaller, but less risky, gain in expected PD. The EDGE program could continue to promote a list of top species conservation priorities through application of probabilistic PD and simple estimates of current extinction probability. The list might be a dynamic one, with all the priority scores updated as extinction probabilities change. Results of recent studies suggest that estimation of extinction probabilities derived from the red list criteria linked to changes in species range sizes may provide estimated probabilities for many different species

  18. Characterization of various tissue mimicking materials for medical ultrasound imaging

    NASA Astrophysics Data System (ADS)

    Thouvenot, Audrey; Poepping, Tamie; Peters, Terry M.; Chen, Elvis C. S.

    2016-04-01

    Tissue mimicking materials are physical constructs exhibiting certain desired properties, which are used in machine calibration, medical imaging research, surgical planning, training, and simulation. For medical ultrasound, those specific properties include acoustic propagation speed and attenuation coefficient over the diagnostic frequency range. We investigated the acoustic characteristics of polyvinyl chloride (PVC) plastisol, polydimethylsiloxane (PDMS), and isopropanol using a time-of-light technique, where a pulse was passed through a sample of known thickness contained in a water bath. The propagation speed in PVC is approximately 1400ms-1 depending on the exact chemical composition, with the attenuation coefficient ranging from 0:35 dB cm-1 at 1MHz to 10:57 dB cm-1 at 9 MHz. The propagation speed in PDMS is in the range of 1100ms-1, with an attenuation coefficient of 1:28 dB cm-1 at 1MHz to 21:22 dB cm-1 at 9 MHz. At room temperature (22 °C), a mixture of water-isopropanol (7:25% isopropanol by volume) exhibits a propagation speed of 1540ms-1, making it an excellent and inexpensive tissue-mimicking liquid for medical ultrasound imaging.

  19. Circumscribed choroidal haemangioma mimicking chronic central serous chorioretinopathy.

    PubMed

    Rahman, W; Horgan, N; Hungerford, J

    2013-03-01

    We describe a rare case of bilateral circumscribed choroidal haemangioma in an otherwise healthy male, which mimicked chronic central serous chorioretinopathy (CSCR). A 52-year-old Asian man presented with a one-year history of visual decline in his left eye. The vision in the right eye had been reduced for 15 years. Visual acuity was 6/60 in the right eye and 6/18 in the left eye. Fundus examination of the right eye revealed an area of discoloration with overlying retinal pigment epithelial changes in the macula and evidence of prior surrounding argon laser photocoagulation. The left macula showed a raised choroidal lesion with overlying retinal pigment epithelial changes and associated subretinal fluid. This appearance illustrates how chronic retinal pigment epithelial alterations associated with longstanding subretinal fluid exudation from circumscribed choroidal haemangiomas may mimick the appearance of chronic central serous chorioretinopathy. B-scan ultrasonography, fluorescein angiography, indocyanine green angiography and optical coherence tomography helped to establish the diagnosis. The active lesion in the left eye was treated with verteporfin photodynamic therapy with improvement in vision.

  20. Spent fuel receipt scenarios study

    SciTech Connect

    Ballou, L.B.; Montan, D.N.; Revelli, M.A.

    1990-09-01

    This study reports on the results of an assignment from the DOE Office of Civilian Radioactive Waste Management to evaluate of the effects of different scenarios for receipt of spent fuel on the potential performance of the waste packages in the proposed Yucca Mountain high-level waste repository. The initial evaluations were performed and an interim letter report was prepared during the fall of 1988. Subsequently, the scope of work was expanded and additional analyses were conducted in 1989. This report combines the results of the two phases of the activity. This study is a part of a broader effort to investigate the options available to the DOE and the nuclear utilities for selection of spent fuel for acceptance into the Federal Waste Management System for disposal. Each major element of the system has evaluated the effects of various options on its own operations, with the objective of providing the basis for performing system-wide trade-offs and determining an optimum acceptance scenario. Therefore, this study considers different scenarios for receipt of spent fuel by the repository only from the narrow perspective of their effect on the very-near-field temperatures in the repository following permanent closure. This report is organized into three main sections. The balance of this section is devoted to a statement of the study objective, a summary of the assumptions. The second section of the report contains a discussion of the major elements of the study. The third section summarizes the results of the study and draws some conclusions from them. The appendices include copies of the waste acceptance schedule and the existing and projected spent fuel inventory that were used in the study. 10 refs., 27 figs.

  1. Europa Explorer Operational Scenarios Development

    NASA Technical Reports Server (NTRS)

    Lock, Robert E.; Pappalardo, Robert T.; Clark, Karla B.

    2008-01-01

    In 2007, NASA conducted four advanced mission concept studies for outer planets targets: Europa, Ganymede, Titan and Enceladus. The studies were conducted in close cooperation with the planetary science community. Of the four, the Europa Explorer Concept Study focused on refining mission options, science trades and implementation details for a potential flagship mission to Europa in the 2015 timeframe. A science definition team (SDT) was appointed by NASA to guide the study. A JPL-led engineering team worked closely with the science team to address 3 major focus areas: 1) credible cost estimates, 2) rationale and logical discussion of radiation risk and mitigation approaches, and 3) better definition and exploration of science operational scenario trade space. This paper will address the methods and results of the collaborative process used to develop Europa Explorer operations scenarios. Working in concert with the SDT, and in parallel with the SDT's development of a science value matrix, key mission capabilities and constraints were challenged by the science and engineering members of the team. Science goals were advanced and options were considered for observation scenarios. Data collection and return strategies were tested via simulation, and mission performance was estimated and balanced with flight and ground system resources and science priorities. The key to this successful collaboration was a concurrent development environment in which all stakeholders could rapidly assess the feasibility of strategies for their success in the full system context. Issues of science and instrument compatibility, system constraints, and mission opportunities were treated analytically and objectively leading to complementary strategies for observation and data return. Current plans are that this approach, as part of the system engineering process, will continue as the Europa Explorer Concept Study moves toward becoming a development project.

  2. Scenarios for coastal vulnerability assessment

    USGS Publications Warehouse

    Nicholls, Robert J.; Woodroffe, Colin D.; Burkett, Virginia; Hay, John; Wong, Poh Poh; Nurse, Leonard; Wolanski, Eric; McLusky, Donald S.

    2011-01-01

    Coastal vulnerability assessments tend to focus mainly on climate change and especially on sea-level rise. Assessment of the influence of nonclimatic environmental change or socioeconomic change is less well developed and these drivers are often completely ignored. Given that the most profound coastal changes of the twentieth century due to nonclimate drivers are likely to continue through the twenty-first century, this is a major omission. It may result in not only overstating the importance of climate change but also overlooking significant interactions of climate change and other drivers. To support the development of policies relating to climate change and coastal management, integrated assessments of climatic change in coastal areas are required, including the effects of all the relevant drivers. This chapter explores the development of scenarios (or "plausible futures") of relevant climate and nonclimate drivers that can be used for coastal analysis, with an emphasis on the nonclimate drivers. It shows the importance of analyzing the impacts of climate change and sea-level rise in a broader context of coastal change and all its drivers. This will improve the analysis of impacts, key vulnerabilities, and adaptation needs and, hence, inform climate and coastal policy. Stakeholder engagement is important in the development of scenarios, and the underlying assumptions need to be explicit, transparent, and open to scientific debate concerning their uncertainties/realism and likelihood.

  3. Tsunami hazard potential for the equatorial southwestern Pacific atolls of Tokelau from scenario-based simulations

    NASA Astrophysics Data System (ADS)

    Orpin, A. R.; Rickard, G. J.; Gerring, P. K.; Lamarche, G.

    2015-07-01

    Devastating tsunami over the last decade have significantly heightened awareness of the potential consequences and vulnerability to tsunami for low-lying Pacific islands and coastal regions. Our tsunami risk assessment for the atolls of the Tokelau Islands was based on a tsunami source-propagation-inundation model using Gerris Flow Solver, adapted from the companion study by Lamarche et al. (2015) for the islands of Wallis and Futuna. We assess whether there is potential for tsunami flooding on any of the village islets from a series of fourteen earthquake-source experiments that apply a combination of well-established fault parameters to represent plausible "high-risk scenarios" for each of the tsunamigenic sources. Earthquake source location and moment magnitude were related to tsunami wave heights and tsunami flood depths simulated for each of the three atolls of Tokelau. This approach was adopted to yield indicative and instructive results for a community advisory, rather than being fully deterministic. Results from our modelling show that wave fields are channelled by the bathymetry of the Pacific basin in such a way that the swathes of the highest waves sweep immediately northeast of the Tokelau Islands. From our series of limited simulations a great earthquake from the Kuril Trench poses the most significant inundation threat to Tokelau, with maximum modelled-wave heights in excess of 1 m, which may last a few hours and include several wave trains. Other sources can impact specific sectors of the atolls, particularly from regional sources to the south, and northern and eastern distant sources that generate trans-Pacific tsunami. In many cases impacts are dependent on the wave orientation and direct exposure to the oncoming tsunami. This study shows that dry areas remain around the villages in nearly all our "worst-case" tsunami simulations of the Tokelau Islands. Consistent with the oral history of little or no perceived tsunami threat, simulations from the

  4. Scenario Development for the Southwestern United States

    NASA Astrophysics Data System (ADS)

    Mahmoud, M.; Gupta, H.; Stewart, S.; Liu, Y.; Hartmann, H.; Wagener, T.

    2006-12-01

    The primary goal of employing a scenario development approach for the U.S. southwest is to inform regional policy by examining future possibilities related to regional vegetation change, water-leasing, and riparian restoration. This approach is necessary due to a lack of existing explicit water resources application of scenarios to the entire southwest region. A formal approach for scenario development is adopted and applied towards water resources issues within the arid and semi-arid regions of the U.S. southwest following five progressive and reiterative phases: scenario definition, scenario construction, scenario analysis, scenario assessment, and risk management. In the scenario definition phase, the inputs of scientists, modelers, and stakeholders were collected in order to define and construct relevant scenarios to the southwest and its water sustainability needs. From stakeholder-driven scenario workshops and breakout sessions, the three main axes of principal change were identified to be climate change, population development patterns, and quality of information monitoring technology. Based on the extreme and varying conditions of these three main axes, eight scenario narratives were drafted to describe the state of each scenario's respective future and the events which led to it. Events and situations are described within each scenario narrative with respect to key variables; variables that are both important to regional water resources (as distinguished by scientists and modelers), and are good tracking and monitoring indicators of change. The current phase consists of scenario construction, where the drafted scenarios are re-presented to regional scientists and modelers to verify that proper key variables are included (or excluded) from the eight narratives. The next step is to construct the data sets necessary to implement the eight scenarios on the respective computational models of modelers investigating vegetation change, water-leasing, and riparian

  5. Hydropower and water supply: competing water uses under a future drier climate modeling scenarios for the Tagus River basin, Portugal

    NASA Astrophysics Data System (ADS)

    Alexandre Diogo, Paulo; Nunes, João Pedro; Carmona Rodrigues, António; João Cruz, Maria; Grosso, Nuno

    2014-05-01

    drought periods, probably more acute by the year 2100 and in scenario A2. As a result, a decrease in inflows to the Castelo de Bode reservoir between 20 to 34% is expected, with emphasis in autumn. While for the near-term scenarios this is mostly due to a decrease in median annual inflow; for the long-term scenarios this is accompanied by lower inter-annual variability and a decrease of magnitude of wet year inflows. Associated with increased precipitation erosion potential, watershed sediment transport will probably tend to increase, enhancing phosphorous transport into surface water and thus contributing to potential eutrophication problems. However, modeling results do not indicate compromising water quality degradation. Decreased reservoir inflows should nevertheless be sufficient to sustain water supply, considering an average annual consumption of 160 hm3 y-1 and the legal prioritization of water supply over hydropower production, as worst case average annual inflows scenarios are estimated between 1 000 and 1 500 hm3 y-1. On the other hand, considering that hydropower comprises downstream releases averaging 1 400 hm3 y-1, restrictions to energy production will probably be required to compensate lower inflow periods and guaranty necessary water supply storage volumes. The presented modeling framework provided an adequate tool for assessing climate change impacts on water resources, demonstrating that climate scenarios are not likely to threaten Lisbon's water supply system but emphasizing the need for adequate reservoir management strategies contemplating the risk of competitive water uses in the Castelo de Bode reservoir.

  6. Eosinophilic Cystitis Mimicking Bladder Tumour – A Rare Case Report

    PubMed Central

    D, Manimaran; T M, Karthikeyan; M, Sreenivasulu; V R, Mrinalini; V, Gopinath

    2013-01-01

    A 16–year–old male presented with urinary urgency, a frequency of 4 months duration and intermittent gross haematuria which were there since one month. Eosinophilia was noted in complete blood count and CT KUB with contrast showed a filling defect in the right lateral wall, over the vesicoureteric junction. Cystoscopy revealed a sessile mass lesion over right vesico–ureteric junction, with bullous oedema . Rest of the mucosa was normal. Transurethral resection of lesion was performed and histological examination showed features of eosinophilic cystitis. Patient was treated with corticosteroids, antimicrobial agents and antihistaminics and he is recovering well. We are presenting this case for its rare presentation and its possibility of mimicking a bladder tumour. Biopsy of the lesion was diagnostic and an early treatment showed good results. PMID:24298501

  7. Surgicel® granuloma mimicking ovarian cancer: A case report

    PubMed Central

    Cormio, Luigi; Cormio, Gennaro; Di Fino, Giuseppe; Scavone, Carmen; Sanguedolce, Francesca; Loizzi, Vera; Carrieri, Giuseppe

    2016-01-01

    Surgicel® is an absorbable sterile mesh composed of oxidized cellulose that is used to control intraoperative capillary or venous bleeding, due to its capacity to bind hemoglobin, thus allowing the formation of an artificial clot. In the present study, a large granuloma mimicking ovarian cancer, which developed following placement of a Surgicel® sponge during a combined pubovaginal sling procedure and cystocele repair, is reported. The aim of the present case report is to emphasize the fact that hemostatic measures should be removed following their use, and to alert surgeons to the risk of using and leaving in situ oxidized cellulose. Furthermore, accurate evaluation of the surgical history of the patient should always be performed prior to attempting surgery. PMID:27446398

  8. Mimicking diffuse supernova antineutrinos with the sun as a source

    SciTech Connect

    Raffelt, G. G.; Rashba, T. I.

    2010-04-15

    Measuring the {nu}-bar{sub e} component of the cosmic diffuse supernova neutrino background (DSNB) is the next ambitious goal for low-energy neutrino astronomy. The largest flux is expected in the lowest accessible energy bin. However, for E {<=} 15 MeV a possible signal can be mimicked by a solar {nu}-bar{sub e} flux that originates from the usual {sup 8}B neutrinos by spin-flavor oscillations. We show that such an interpretation is possible within the allowed range of neutrino electromagnetic transition moments and solar turbulent field strengths and distributions. Therefore, an unambiguous detection of the DSNB requires a significant number of events at E {>=} 15 MeV.

  9. Enterobiasis in ectopic locations mimicking tumor-like lesions.

    PubMed

    Pampiglione, Silvio; Rivasi, Francesco

    2009-01-01

    Both the clinical and the histopathological diagnostic difficulties of oxyuriasis in unusual sites and their importance from a clinical point of view are pointed out. The authors report two ectoptic cases of enterobiasis observed in Northern Italy, one located in a fallopian tube of a 57-year-old woman and the other in a perianal subcutaneous tissue of a 59-year-old man, mimicking tumor-like lesions. The authors take advantage of the occasion to focus the attention of the medical world on this subject, lamenting the scarce importance given to this parasitosis in university courses of medical schools and in medical textbooks as it is incorrectly considered "out-of-fashion."

  10. Enzyme-Mimicking properties of silicates and other minerals

    NASA Astrophysics Data System (ADS)

    Siegel, B. Z.; Siegel, S. M.

    The adsorptive and/or catalytic properties of clays, silicates in general, and other minerals are well known. More recently, their probable role in prebiotic syntheses of bio-organic compounds has become a matter of record. We demonstrate that, in addition to their role in de novo formation of important biomolecules, clays, micas, fibrous silicates and other minerals mimick the activities of contemporary enzymes including oxidases, esterases, phosphatases and glucosidases. The existence of such capabilities in substances likely to be represented on the surfaces of Earth-like planets may offer a challenge to the technology and design of remote life detection systems which must then distinguish between bona fide biological chemistry and mineral-base pseudometabolism. It also raises questions about the importance of mineral surfaces in post-mortem transformations of organic metabolites in our own biosphere.

  11. A Rare Presentation of Peritoneal Tuberculosis Mimicking Malignancy

    PubMed Central

    Swe, Thein; Naing, Akari Thein; Phyo, Zaw Win; Thwin, Malar

    2016-01-01

    Our search of literature revealed combined elevations of serum cancer antigen 125 levels and rheumatoid factor levels in a patient with peritoneal tuberculosis has rarely been reported. Thus, we describe the case of a 63-year-old female with large abdominal ascites and malignancy was ruled out with biopsy. High levels of serum cancer antigen and rheumatoid factor were noted. Physicians should be aware that tuberculosis infection could induce elevation of rheumatoid factor levels in the absence of rheumatologic symptoms or disease. A high index of suspicion is required because peritoneal tuberculosis is a great mimicker of other abdominal pathology, especially intraabdominal malignancies and can mislead physicians to undergo unnecessary interventions. PMID:27900335

  12. Blood-Mimicking Fluid for Testing Ultrasonic Diagnostic Instrument

    NASA Astrophysics Data System (ADS)

    Tanaka, Kouhei; Yoshida, Tomoji; Sato, Kazuishi; Kondo, Toshio; Yasukawa, Kazuhiro; Miyamoto, Nobuaki; Taniguchi, Masahiko

    2012-07-01

    We present a blood-mimicking fluid (BMF) for the Doppler test object of medical diagnostic instruments. Accurate measurement in a flow Doppler test requires a BMF that has the acoustic velocity and density defined in the International Electrotechnical Commission (IEC) standard, and furthermore, they must be stable over time. To formulate a fluid with the desired density and acoustic velocity, we have developed a new fluid made of glycerine and water-soluble silicone oil. The new BMF includes dispersed polystyrene particles as scatterers. The density of the liquid can be adjusted to maintain it at the same value as that of the polystyrene particles, thus ensuring neutral buoyancy of the particles. The MBF was stable over a period of 2 weeks, during which the density and acoustic velocity did not change.

  13. Dense Deposit Disease Mimicking a Renal Small Vessel Vasculitis.

    PubMed

    Singh, Lavleen; Singh, Geetika; Bhardwaj, Swati; Sinha, Aditi; Bagga, Arvind; Dinda, Amit

    2016-01-01

    Dense deposit disease is caused by fluid-phase dysregulation of the alternative complement pathway and frequently deviates from the classic membranoproliferative pattern of injury on light microscopy. Other patterns of injury described for dense deposit disease include mesangioproliferative, acute proliferative/exudative, and crescentic GN. Regardless of the histologic pattern, C3 glomerulopathy, which includes dense deposit disease and C3 GN, is defined by immunofluorescence intensity of C3c two or more orders of magnitude greater than any other immune reactant (on a 0-3 scale). Ultrastructural appearances distinguish dense deposit disease and C3 GN. Focal and segmental necrotizing glomerular lesions with crescents, mimicking a small vessel vasculitis such as ANCA-associated GN, are a very rare manifestation of dense deposit disease. We describe our experience with this unusual histologic presentation and distinct clinical course of dense deposit disease, discuss the pitfalls in diagnosis, examine differential diagnoses, and review the relevant literature.

  14. Isolated angiitis in the hypothalamus mimicking brain tumor.

    PubMed

    Tsutsumi, Satoshi; Ito, Masanori; Yasumoto, Yukimasa; Kaneda, Kazuhiko

    2008-01-01

    A 64-year-old female presented with exaggerating somnolence without contributory medical and lifestyle histories. She was not aware of any preceding infection or headache. Cerebral magnetic resonance imaging demonstrated an isolated enhanced mass in the hypothalamus without meningeal enhancement. Blood and cerebrospinal fluid examinations showed no significant findings except for hypernatremia and hyperprolactinemia. She underwent an open biopsy via the interhemispheric route. Histological examination revealed marked perivascular lymphocytic aggregation with polyclonal immunostaining both for B and T lymphocytes. No findings suggestive of underlying malignancy were recognized. Extensive work-up aiming at systemic vasculitis and lymphoma revealed no signs of extracranial lesion, so the most probable diagnosis was isolated angiitis in the hypothalamus. Angiitis may originate from the hypothalamus and should be considered in the differential diagnosis of hypothalamic lesion mimicking brain tumor on neuroimaging.

  15. An ideal blood mimicking fluid for doppler ultrasound phantoms.

    PubMed

    Samavat, H; Evans, J A

    2006-10-01

    In order to investigate the problems of detecting tumours by ultrasound it is very important to have a portable Doppler flow test object to use as a standardising tool. The flow Doppler test objects are intended to mimic the flow in human arteries. To make the test meaningful, the acoustic properties of the main test object components (tissue and blood mimic) should match closely the properties of the corresponding human tissues, while the tube should ideally have little influence. The blood mimic should also represent the haemodynamic properties of blood. An acceptable flow test object has been designed to closely mimic blood flow in arteries. We have evaluated the properties of three blood mimicking fluid: two have been described recently in the literature, the third is a local design. One of these has emerged as being particularly well matched to the necessary characteristics for in-vitro work.

  16. Granulomatous prostatitis after intravesical immunotherapy mimicking prostate cancer.

    PubMed

    Białek, Waldemar; Rudzki, Sławomir; Iberszer, Paweł; Wronecki, Lech

    2016-12-01

    Intravesical immunotherapy with attenuated strains of Mycobacterium bovis is a widely used therapeutic option in patients with non-muscle-invasive transitional cell carcinoma of the bladder. A rare complication of intravesical therapy with the Bacillus Calmette-Guérin vaccine is granulomatous prostatitis, which due to increasing levels of prostate-specific antigen and abnormalities found in transrectal examination of the prostate may suggest concomitant prostate cancer. A case of extensive granulomatous prostatitis in a 61-year-old patient which occurred after the first course of a well-tolerated Bacillus Calmette-Guérin therapy is presented. Due to abnormalities found in rectal examination and an abnormal transrectal ultrasound image of the prostate with extensive infiltration mimicking neoplastic hyperplasia a core biopsy of the prostate was performed. Histopathological examination revealed inflammatory infiltration sites of tuberculosis origin.

  17. Granulomatous prostatitis after intravesical immunotherapy mimicking prostate cancer

    PubMed Central

    Rudzki, Sławomir; Iberszer, Paweł; Wronecki, Lech

    2016-01-01

    Intravesical immunotherapy with attenuated strains of Mycobacterium bovis is a widely used therapeutic option in patients with non-muscle-invasive transitional cell carcinoma of the bladder. A rare complication of intravesical therapy with the Bacillus Calmette-Guérin vaccine is granulomatous prostatitis, which due to increasing levels of prostate-specific antigen and abnormalities found in transrectal examination of the prostate may suggest concomitant prostate cancer. A case of extensive granulomatous prostatitis in a 61-year-old patient which occurred after the first course of a well-tolerated Bacillus Calmette-Guérin therapy is presented. Due to abnormalities found in rectal examination and an abnormal transrectal ultrasound image of the prostate with extensive infiltration mimicking neoplastic hyperplasia a core biopsy of the prostate was performed. Histopathological examination revealed inflammatory infiltration sites of tuberculosis origin. PMID:28138411

  18. Adenoid Cystic Carcinoma Mimicking an Oroantral Fistula: A Case Report

    PubMed Central

    Monteiro, Bárbara Vanessa de Brito; Grempel, Rafael Grotta; Gomes, Daliana Queiroga de Castro; Godoy, Gustavo Pina; Miguel, Márcia Cristina da Costa

    2013-01-01

    Introduction Adenoid cystic carcinoma (ACC) is one of the most frequent malignant salivary gland tumors, which commonly affects the minor salivary glands of the mouth and is rare in the nose and paranasal sinuses. In the maxillary sinus, ACC can mimic inflammatory diseases and has a poor prognosis. Objective To report a case of a 50-year-old man with ACC of the maxillary sinus whose clinical findings in the alveolar ridge mimicked an oroantral fistula. Case Report An excisional biopsy was performed and histopathologic analysis revealed ACC. Lung metastases and residual tumor in the maxillary sinus were detected by imaging methods. In view of the poor general health of the patient, no new surgical intervention was performed and he was only treated by radiotherapy and follow-up. Conclusion Although rare in the maxillary sinus, ACC should be included in the differential diagnosis of lesions affecting this site. PMID:25992095

  19. Mesenteric lymphangioma mimicking a cystic ovarian mass on imaging.

    PubMed

    Hitzerd, Emilie; van Hamont, Dennis; Pijnenborg, Johanna M A

    2016-02-01

    Pelvic cystic masses are frequently observed in women. Most lesions are benign and of ovarian origin. However, non-ovarian lesions can be easily confused with cystic ovarian masses on imaging, which hampers diagnostic and therapeutic management. In this report, a rare case of mesenteric lymphangioma mimicking an ovarian cystic mass, discovered as an incidental finding on orthopaedic MRI in an adult female, is presented. The report highlights the sometimes difficult diagnostic process of pelvic cystic masses, due to an extensive differential diagnosis and the fact that imaging is often inconclusive. Even though most cystic masses are of ovarian origin, non-ovarian causes can mimic ovarian masses and should be considered as differential diagnoses. Surgical exploration may be necessary to exclude malignant causes.

  20. Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus

    PubMed Central

    Hirai, Hiroyuki; Midorikawa, Sanae; Suzuki, Shinichi; Sasano, Hironobu; Watanabe, Tsuyoshi; Satoh, Hiroaki

    2016-01-01

    We herein present the findings of a 42-year-old woman with either adrenal pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted somatostatin, thus mimicking insulin-dependent diabetes mellitus. Pheochromocytoma was clinically diagnosed based on scintigraphy, elevated catecholamine levels, and finally a histopathological analysis of resected specimens. The patient had diabetic ketosis, requiring 40 U insulin for treatment. Following laparoscopic adrenalectomy, insulin therapy was discontinued and the urinary c-peptide levels changed from 5.5-9.0 to 81.3-87.0 μg/day. Histologically, somatostatin immunoreactivity was detected and the somatostatin levels were elevated in the serum-like fluid obtained from the tumor. Clinicians should be aware of the possible occurrence of simultaneous ectopic hormone secretion in patients with pheochromocytoma. PMID:27746437

  1. Recurrent histoplasmosis in AIDS mimicking a colonic carcinoma.

    PubMed

    Aisenberg, G; Marcos, L A; Ogbaa, I

    2009-06-01

    The prevalence rate of lower gastrointestinal bleeding in patients with AIDS is around 2.6%. A 42-year-old woman with AIDS (CD(4) count 9/microL) and recently treated for disseminated histoplasmosis presented to the emergency room with melena, severe anaemia and fever. A colonoscopy showed an umbilicated colonic nodule mimicking a carcinoma of the colon. The biopsy showed intracytoplasmic microorganisms compatible with Histoplasma capsulatum. She had poor compliance to the itraconazole when discharge on previous admission. Despite the fact that colonic histoplasmosis is uncommon, the mortality rate is around 8% and clinicians should be aware of the clinical presentation of histoplasmosis when recur, especially in patients not taking the itraconazole for long-term treatment.

  2. Atypical Ormond's disease associated with bile duct stricture mimicking cholangiocarcinoma.

    PubMed

    Quante, Michael; Appenrodt, Beate; Randerath, Simone; Wolff, Martin; Fischer, Hans-Peter; Sauerbruch, Tilman

    2009-01-01

    A 55-year-old woman with suspected hilar cholangiocarcinoma presented with jaundice and dilated intrahepatic bile ducts owing to high-grade hepatic duct confluence stenosis. The suspected tumour and the entire extrahepatic bile duct system were resected and Roux-en-Y hepaticojejunostomy was performed. Histological investigations showed perihepatic fibrosis but no signs of malignancy. One year later the patient developed bilateral hydronephrosis caused by ureteral obstruction. Since the patient had a gynaecological history of widespread inflammation, she was referred for transabdominal operative ureterolysis combined with hysterectomy and adnexectomy. Histological investigations as well as fluorodeoxyglucose-positron emission tomography (FDG-PET) and computed tomography (CT) findings were compatible with retroperitoneal fibrosis (Ormond's disease). Treatment with tamoxifen was initiated. To the best of our knowledge, only a few cases of intraperitoneal fibroses mimicking cholangiocarcinoma followed by the typical symptoms of retroperitoneal Ormond's disease have been reported.

  3. Liquid optical phantoms mimicking spectral characteristics of laboratory mouse biotissues

    NASA Astrophysics Data System (ADS)

    Loginova, D. A.; Sergeeva, E. A.; Krainov, A. D.; Agrba, P. D.; Kirillin, M. Yu

    2016-06-01

    Optical phantoms mimicking optical properties of real biotissues in the visible and IR spectral regions are developed based on measurements of the spectral characteristics of ex vivo samples of laboratory mouse biotissues. The phantoms are composed of aqueous solutions of Lipofundin, Indian ink and red ink with different spectral characteristics. The deviations of the measured absorption and scattering coefficients of phantoms in the wavelength range 480 - 580 nm from the corresponding values for real biotissues do not exceed 25% and 2%, respectively. For phantoms in the wavelength region 580 - 880 nm, the deviations of the absorption coefficient do not exceed 40% and the deviations of the scattering coefficient do not exceed 25%. These values, in general, fall within the range of variations for different individual mice of one strain.

  4. An Adolescent Patient with Scabies Mimicking Gottron Papules.

    PubMed

    Yoshinaga, Eiji; Oiso, Naoki; Kawara, Shigeru; Kawada, Akira

    2009-01-13

    Atypical features of scabies occur in infants and children and patients with prolonged use of corticosteroids or immunosuppression. We report a non-immunosuppressed 15-year-old female case of scabies showing scaly reddish papules over the proximal interphalangeal joints mimicking Gottron papules in classic dermatomyositis. Periungal erythema was also seen. Four months' topical corticosteroids from previous clinics had been used. Dermoscopic findings were consistent with typical pictures of scabies. Scraping of hand crusts demonstrated scabies mites and ova. Skin lesions of the patient were cured with oral ivermectin and topical 10% crotamiton. This case suggests that a lesion resembling Gottron papules may be added to the panel of unusual presentations of scabies.

  5. An Adolescent Patient with Scabies Mimicking Gottron Papules

    PubMed Central

    Yoshinaga, Eiji; Oiso, Naoki; Kawara, Shigeru; Kawada, Akira

    2010-01-01

    Atypical features of scabies occur in infants and children and patients with prolonged use of corticosteroids or immunosuppression. We report a non-immunosuppressed 15-year-old female case of scabies showing scaly reddish papules over the proximal interphalangeal joints mimicking Gottron papules in classic dermatomyositis. Periungal erythema was also seen. Four months’ topical corticosteroids from previous clinics had been used. Dermoscopic findings were consistent with typical pictures of scabies. Scraping of hand crusts demonstrated scabies mites and ova. Skin lesions of the patient were cured with oral ivermectin and topical 10% crotamiton. This case suggests that a lesion resembling Gottron papules may be added to the panel of unusual presentations of scabies. PMID:21173918

  6. Intussusception of Rectosigmoid Colon Cancer Mimicking a Pedunculated Tumor

    PubMed Central

    Saigusa, Susumu; Ohi, Masaki; Imaoka, Hiroki; Shimura, Tadanobu; Inoue, Yasuhiro; Kusunoki, Masato

    2014-01-01

    Intussusception in adults is a rare phenomenon involving the colon in approximately 20% of cases. A 65-year-old man was hospitalized with anorexia, anemia, dehydration, and melena. Digital rectal examination revealed a palpable mass approximately 5 cm from the anal verge. The mass moved between the rectosigmoid colon and the rectum below the peritoneal reflection during radiographic examinations and during sigmoidoscopy. We strongly suspected a rectosigmoid pedunculated tumor and performed a low anterior resection. Intraoperatively we observed intussusception of the rectosigmoid colon with easy manual reduction. The tumor was palpable in the rectosigmoid colon. The postoperative course was uneventful. This case illustrates intussusception of a rectosigmoid type 1 colon adenocarcinoma mimicking a pedunculated tumor. PMID:24963434

  7. Tissue-mimicking gel phantoms for thermal therapy studies.

    PubMed

    Dabbagh, Ali; Abdullah, Basri Johan Jeet; Ramasindarum, Chanthiriga; Abu Kasim, Noor Hayaty

    2014-10-01

    Tissue-mimicking phantoms that are currently available for routine biomedical applications may not be suitable for high-temperature experiments or calibration of thermal modalities. Therefore, design and fabrication of customized thermal phantoms with tailored properties are necessary for thermal therapy studies. A multitude of thermal phantoms have been developed in liquid, solid, and gel forms to simulate biological tissues in thermal therapy experiments. This article is an attempt to outline the various materials and techniques used to prepare thermal phantoms in the gel state. The relevant thermal, electrical, acoustic, and optical properties of these phantoms are presented in detail and the benefits and shortcomings of each type are discussed. This review could assist the researchers in the selection of appropriate phantom recipes for their in vitro study of thermal modalities and highlight the limitations of current phantom recipes that remain to be addressed in further studies.

  8. Dense Deposit Disease Mimicking a Renal Small Vessel Vasculitis

    PubMed Central

    Singh, Lavleen; Bhardwaj, Swati; Sinha, Aditi; Bagga, Arvind; Dinda, Amit

    2016-01-01

    Dense deposit disease is caused by fluid-phase dysregulation of the alternative complement pathway and frequently deviates from the classic membranoproliferative pattern of injury on light microscopy. Other patterns of injury described for dense deposit disease include mesangioproliferative, acute proliferative/exudative, and crescentic GN. Regardless of the histologic pattern, C3 glomerulopathy, which includes dense deposit disease and C3 GN, is defined by immunofluorescence intensity of C3c two or more orders of magnitude greater than any other immune reactant (on a 0–3 scale). Ultrastructural appearances distinguish dense deposit disease and C3 GN. Focal and segmental necrotizing glomerular lesions with crescents, mimicking a small vessel vasculitis such as ANCA-associated GN, are a very rare manifestation of dense deposit disease. We describe our experience with this unusual histologic presentation and distinct clinical course of dense deposit disease, discuss the pitfalls in diagnosis, examine differential diagnoses, and review the relevant literature. PMID:26361799

  9. Sarcoidosis mimicking a venous ulcer: a case report.

    PubMed

    Joshi, Smita S; Romanelli, Paolo; Kirsner, Robert S

    2009-11-01

    Sarcoidosis--a chronic, multisystem disease of unknown etiology characterized by noncaseating granulomas--may cause ulcerative lesions, particularly in African American women. A case of ulcerative sarcoidosis mimicking a venous ulcer is presented. The patient is a 44-year-old African American hypertensive, obese woman with a nonhealing medially based lower leg ulcer of 3 years' duration clinically consistent with a venous ulcer. The ulcer did not heal with compression therapy and pentoxifylline. Subsequent biopsies showed granulomatous inflammation consistent with sarcoidosis. When intralesional triamcinolone was added to compression therapy, the ulcer resolved after 3 months. Given its propensity toward formation on the lower extremities and ulcerative and atrophic appearance, ulcerative sarcoidosis should be considered in the differential diagnosis of a venous ulcer refractory to standard therapy, especially in African American women.

  10. Huge uterine-cervical diverticulum mimicking as a cyst.

    PubMed

    Chufal, S; Thapliyal, Naveen; Gupta, Manoj; Pangtey, Nirmal

    2012-01-01

    Here we report an incidental huge uterine-cervical diverticulum from a total abdominal hysterectomy specimen in a perimenopausal woman who presented with acute abdominal pain. The diverticulum was mimicking with various cysts present in the lateral side of the female genital tract. Histopathological examination confirmed this to be a cervical diverticulum with communication to uterine cavity through two different openings. They can attain huge size if left ignored for long duration and present a diagnostic challenge to clinicians, radiologists, as well as pathologists because of its extreme rarity. Therefore, diverticula should also be included as a differential diagnosis. Its histopathological confirmation also highlights that diverticula can present as an acute abdomen, requiring early diagnosis with appropriate timely intervention. Immunohistochemistry CD 10 has also been used to differentiate it from a mesonephric cyst.

  11. Subungual onycholemmal cyst of the toenail mimicking subungual melanoma.

    PubMed

    Busquets, Joanna; Banala, Mounica; Campanelli, Carmen; Sahu, Joya; Lee, Jason B

    2016-08-01

    This report highlights a rare case of a woman with horizontal ridging and tenderness of the right great toenail associated with dyspigmentation of 5 years' duration. Histopathology revealed a cystic structure with an epithelial lining mostly reminiscent of an isthmus-catagen cyst admixed with the presence of both an intermittent, focal granular layer and an eosinophilic cuticle surrounding pink, laminated keratin, most consistent with a diagnosis of subungual onycholemmal cyst (SOC). It is a rare and distinctive nail abnormality occurring in the dermis of the nail bed. We present a case of an SOC in the toenail mimicking subungual malignant melanoma, which may be an underrecognized and common entity that must be considered when discussing tumors of the nail unit, especially subungual melanoma.

  12. A salivary gland adenocarcinoma mimicking a microcystic adnexal carcinoma.

    PubMed

    Basile, John R; Lin, Yi-Ling

    2010-04-01

    The microcystic adnexal carcinoma (MAC) is a rare, slow-growing but locally aggressive neoplasm arising in the midface and lips of middle-aged adults. The MAC is histologically characterized by deeply infiltrating nests and islands of basaloid or squamous cells forming cysts and ductal structures, proliferating in a dense sclerotic stroma and occasionally exhibiting perineural invasion. We describe a salivary gland adenocarcinoma arising in the lower lip, characterized by ductal structures and cords, 3-5 cell layers in thickness, set in a dense fibrous stroma and also invading nerves, thus mimicking a MAC in both its clinical and its histopathologic appearance. The diagnostic dilemma presented by this lesion is discussed, along with a differential diagnosis and brief review of the literature.

  13. Optofluidic phantom mimicking optical properties of porcine livers

    SciTech Connect

    Long, Ruiqi; King, Travis; Akl, Tony; Ericson, Milton Nance; Wilson, Mark A.; Cote, Gerard L.; McShane, Michael J.

    2011-01-01

    One strategy for assessing efficacy of a liver transplant is to monitor perfusion and oxygenation after transplantation. An implantable optical sensor is being developed to overcome inadequacies of current monitoring approaches. To facilitate sensor design while minimizing animal use, a polydimethylsiloxane (PDMS)-based liver phantom was developed to mimic the optical properties of porcine liver in the 630-1000 nm wavelength range and the anatomical geometry of liver parenchyma. Using soft lithography to construct microfluidic channels in pigmented elastomer enabled the 2D approximation of hexagonal liver lobules with 15mm sinusoidal channels, which will allow perfusion with blood-mimicking fluids to facilitate the development of the liver perfusion and oxygenation monitoring system.

  14. Acoustical characterization of polysaccharide polymers tissue-mimicking materials.

    PubMed

    Cuccaro, Rugiada; Musacchio, Chiara; Giuliano Albo, P Alberto; Troia, Adriano; Lago, Simona

    2015-02-01

    Tissue-mimicking phantoms play a crucial role in medical ultrasound research because they can simulate biological soft tissues. In last years, many types of polymeric tissues have been proposed and characterized from an acoustical and a thermal point of view, but, rarely, a deep discussion about the quality of the measurements, in terms of the uncertainty evaluation, has been reported. In this work, considering the necessity to develop laboratory standards for the measurement of ultrasonic exposure and dose quantities, a detailed description of the experimental apparatuses for the sound speed and the attenuation coefficient measurements is given, focusing the attention on the uncertainty evaluation both of the results and analysis algorithms. In particular, this algorithm reveals a novel empirical relation, fixing a limit to the energy content (therefore limits the number of cycles) of the three parts in which the authors have proposed to divide the acoustical signal. Furthermore, the realisation of multi-components phantoms, Agar and Phytagel based tissue-mimicking gels along with others long chain molecules (dextrane or polyvinyl alcohol) and scattering materials (silicon carbide and kieselguhr) are investigated. This paper reports accurate speed of sound and attenuation coefficient measurements. Speed of sound is measured by a pulse-echo technique in far-field condition, using an optical glass buffer rod; while attenuation coefficient is determined by an insertion technique, using demineralized water as reference material. The experimental sound speed results are subjected to an overall estimated relative uncertainty of about 1.5% and the attenuation coefficient uncertainty is less than 2.5%. For the development of laboratory standards, a detailed analysis of the measurement uncertainty is fundamental to make sample properties comparable. The authors believe this study could represent the right direction to make phantoms characterizations referable and traceable.

  15. The ShakeOut Scenario

    USGS Publications Warehouse

    Jones, Lucile M.; Bernknopf, Richard; Cox, Dale; Goltz, James; Hudnut, Kenneth; Mileti, Dennis; Perry, Suzanne; Ponti, Daniel; Porter, Keith; Reichle, Michael; Seligson, Hope; Shoaf, Kimberley; Treiman, Jerry; Wein, Anne

    2008-01-01

    This is the initial publication of the results of a cooperative project to examine the implications of a major earthquake in southern California. The study comprised eight counties: Imperial, Kern, Los Angeles, Orange, Riverside, San Bernardino, San Diego, and Ventura. Its results will be used as the basis of an emergency response and preparedness exercise, the Great Southern California ShakeOut, and for this purpose we defined our earthquake as occurring at 10:00 a.m. on November 13, 2008. As members of the southern California community use the ShakeOut Scenario to plan and execute the exercise, we anticipate discussion and feedback. This community input will be used to refine our assessment and will lead to a formal publication in early 2009. Our goal in the ShakeOut Scenario is to identify the physical, social and economic consequences of a major earthquake in southern California and in so doing, enable the users of our results to identify what they can change now?before the earthquake?to avoid catastrophic impact after the inevitable earthquake occurs. To do so, we had to determine the physical damages (casualties and losses) caused by the earthquake and the impact of those damages on the region?s social and economic systems. To do this, we needed to know about the earthquake ground shaking and fault rupture. So we first constructed an earthquake, taking all available earthquake research information, from trenching and exposed evidence of prehistoric earthquakes, to analysis of instrumental recordings of large earthquakes and the latest theory in earthquake source physics. We modeled a magnitude (M) 7.8 earthquake on the southern San Andreas Fault, a plausible event on the fault most likely to produce a major earthquake. This information was then fed forward into the rest of the ShakeOut Scenario. The damage impacts of the scenario earthquake were estimated using both HAZUS-MH and expert opinion through 13 special studies and 6 expert panels, and fall into four

  16. Superclustering in the explosion scenario

    NASA Technical Reports Server (NTRS)

    Weinberg, David H.; Ostriker, Jeremiah P.; Dekel, Avishai

    1989-01-01

    A simple toy model is used to study the spatial distribution of rich clusters in a generic type of explosion scenario. The model, parameterized by the distribution of shell radii and the filling factor, places spherical shells at random and identifies each 'knot' as a cluster. The resulting cluster correlation function is close to a power law extending to the diameter of the largest spheres. Richer clusters form at the intersections of bigger shells and so have stronger correlations. Typical shell radii and filling factors are required to produce the observed number density of clusters. Models with a power-law radius distribution also reproduce the richness distribution of clusters in the Abell catalog. Supercluster multiplicity functions, void probabilities, number counts, topology statistics, and velocity correlations confirm the presence of strong superclustering and quantify the non-Gaussian nature of the model.

  17. Radiation Detection Computational Benchmark Scenarios

    SciTech Connect

    Shaver, Mark W.; Casella, Andrew M.; Wittman, Richard S.; McDonald, Ben S.

    2013-09-24

    Modeling forms an important component of radiation detection development, allowing for testing of new detector designs, evaluation of existing equipment against a wide variety of potential threat sources, and assessing operation performance of radiation detection systems. This can, however, result in large and complex scenarios which are time consuming to model. A variety of approaches to radiation transport modeling exist with complementary strengths and weaknesses for different problems. This variety of approaches, and the development of promising new tools (such as ORNL’s ADVANTG) which combine benefits of multiple approaches, illustrates the need for a means of evaluating or comparing different techniques for radiation detection problems. This report presents a set of 9 benchmark problems for comparing different types of radiation transport calculations, identifying appropriate tools for classes of problems, and testing and guiding the development of new methods. The benchmarks were drawn primarily from existing or previous calculations with a preference for scenarios which include experimental data, or otherwise have results with a high level of confidence, are non-sensitive, and represent problem sets of interest to NA-22. From a technical perspective, the benchmarks were chosen to span a range of difficulty and to include gamma transport, neutron transport, or both and represent different important physical processes and a range of sensitivity to angular or energy fidelity. Following benchmark identification, existing information about geometry, measurements, and previous calculations were assembled. Monte Carlo results (MCNP decks) were reviewed or created and re-run in order to attain accurate computational times and to verify agreement with experimental data, when present. Benchmark information was then conveyed to ORNL in order to guide testing and development of hybrid calculations. The results of those ADVANTG calculations were then sent to PNNL for

  18. Nanofibrous heparin and heparin-mimicking multilayers as highly effective endothelialization and antithrombogenic coatings.

    PubMed

    Nie, Chuanxiong; Ma, Lang; Cheng, Chong; Deng, Jie; Zhao, Changsheng

    2015-03-09

    Combining the advantages of the fibrous nanostructure of carbon nanotubes (CNTs) and the bioactivities of heparin/heparin-mimicking polyanions, functional nanofibrous heparin or heparin-mimicking multilayers were constructed on PVDF membrane with highly promoted endothelialization and antithrombogenic activities. Oxidized CNT (oCNT) was first functionalized with water-soluble chitosan (polycation), then enwrapped with heparin or a typical sulfonated heparin-mimicking polymers (poly(sodium 4-styrenesulfonate-co-sodium methacrylate)) to construct the multilayers. Then, the surface-deposited multilayers were constructed via electrostatic layer-by-layer assembly of the functionalized oCNTs. The scanning electron microscope and atom force microscope images confirmed that the coated multilayers exhibited nanofibrous and porous structure. The live/dead cell staining and cell viability assay results indicated that the coated nanofibrous multilayers had excellent compatibility with endothelial cells. The cell morphology observation further confirmed the promotion ability of surface endothelialization due to the coated heparin/heparin-mimicking multilayers. Further systematical evaluation on blood compatibility revealed that the surface heparin/heparin-mimicking multilayer-coated membranes also had significantly improved blood compatibility including restrained platelet adhesion and activation, prolonged blood clotting times, and inhibited activation of coagulation and complement factors. In summary, the proposed nanofibrous multilayers integrated endothelialization and antithrombogenic properties; meanwhile, the heparin-mimicking coating validated comparable performances as heparin coating. Herein, it is expected that the surface coating of nanofibrous multilayers, especially the facilely constructed heparin-mimicking coating, may have great application potential in biomedical fields.

  19. Web Based Tool for Mission Operations Scenarios

    NASA Technical Reports Server (NTRS)

    Boyles, Carole A.; Bindschadler, Duane L.

    2008-01-01

    A conventional practice for spaceflight projects is to document scenarios in a monolithic Operations Concept document. Such documents can be hundreds of pages long and may require laborious updates. Software development practice utilizes scenarios in the form of smaller, individual use cases, which are often structured and managed using UML. We have developed a process and a web-based scenario tool that utilizes a similar philosophy of smaller, more compact scenarios (but avoids the formality of UML). The need for a scenario process and tool became apparent during the authors' work on a large astrophysics mission. It was noted that every phase of the Mission (e.g., formulation, design, verification and validation, and operations) looked back to scenarios to assess completeness of requirements and design. It was also noted that terminology needed to be clarified and structured to assure communication across all levels of the project. Attempts to manage, communicate, and evolve scenarios at all levels of a project using conventional tools (e.g., Excel) and methods (Scenario Working Group meetings) were not effective given limitations on budget and staffing. The objective of this paper is to document the scenario process and tool created to offer projects a low-cost capability to create, communicate, manage, and evolve scenarios throughout project development. The process and tool have the further benefit of allowing the association of requirements with particular scenarios, establishing and viewing relationships between higher- and lower-level scenarios, and the ability to place all scenarios in a shared context. The resulting structured set of scenarios is widely visible (using a web browser), easily updated, and can be searched according to various criteria including the level (e.g., Project, System, and Team) and Mission Phase. Scenarios are maintained in a web-accessible environment that provides a structured set of scenario fields and allows for maximum

  20. Innovations in science and scenarios for assessment.

    PubMed

    Kunkel, Kenneth E; Moss, Richard; Parris, Adam

    Scenarios for the Third National Climate Assessment (NCA3) were produced for physical climate and sea level rise with substantial input from disciplinary and regional experts. These scenarios underwent extensive review and were published as NOAA Technical Reports. For land use/cover and socioeconomic conditions, scenarios already developed by other agencies were specified for use in the NCA3. Efforts to enhance participatory scenario planning as an assessment activity were pursued, but with limited success. Issues and challenges included the timing of availability of scenarios, the need for guidance in use of scenarios, the need for approaches to nest information within multiple scales and sectors, engagement and collaboration of end users in scenario development, and development of integrated scenarios. Future assessments would benefit from an earlier start to scenarios development, the provision of training in addition to guidance documents, new and flexible approaches for nesting information, ongoing engagement and advice from both scientific and end user communities, and the development of consistent and integrated scenarios.

  1. Innovations in science and scenarios for assessment

    SciTech Connect

    Kunkel, Kenneth E.; Moss, Richard; Parris, Adam

    2015-08-29

    Scenarios for the Third National Climate Assessment (NCA3) were produced for physical climate and sea level rise with substantial input from disciplinary and regional experts. These scenarios underwent extensive review and were published as NOAA Technical Reports. For land use/cover and socioeconomic conditions, scenarios already developed by other agencies were specified for use in the NCA3. Efforts to enhance participatory scenario planning as an assessment activity were pursued, but with limited success. Issues and challenges included the timing of availability of scenarios, the need for guidance in use of scenarios, the need for approaches to nest information within multiple scales and sectors, engagement and collaboration of end users in scenario development, and development of integrated scenarios. Future assessments would benefit from an earlier start to scenarios development, the provision of training in addition to guidance documents, new and flexible approaches for nesting information, ongoing engagement and advice from both scientific and end user communities, and the development of consistent and integrated scenarios.

  2. The narcissistic scenarios of parenthood.

    PubMed

    Manzano, J; Palacio Espasa, F; Zilkha, N

    1999-06-01

    The authors begin by pointing out that Freud always considered parent-child relations in terms of the child's psychic development and took little account of the parents' experience of the relationship and its psychic effects on them. They recall Freud's distinction between the anaclitic and narcissistic modes of relationship and show how these are unconsciously embodied and enacted in varying proportions in the cases observed in their own clinical practice of therapeutic consultations with parents and young children. After a review of the relevant psychoanalytic literature, the authors present their concept of the narcissistic scenarios of parenthood, which include parental projection on to the child, parental counter-identification, a specific aim and a relational dynamic that is acted out. Depending on the individual situation, the effects may help to structure the developing psyche or, if the narcissistic element is excessive, they may be pathological. The authors consider the literature on the application of psychoanalysis to therapeutic interventions with parents and children, stressing the technical importance of establishing a therapeutic focus. These ideas are illustrated by a detailed case history showing the interaction between a mother and a 4-year-old girl and how it was modified by a short therapy. The differences between interpretation in this situation and in the classical psychoanalytic setting are explained, and the paper ends with some comments on the transmission of psychic elements from generation to generation.

  3. Agricultural Baseline (BL0) scenario

    SciTech Connect

    Davis, Maggie R.; Hellwinckel, Chad M; Eaton, Laurence; Turhollow, Anthony; Brandt, Craig; Langholtz, Matthew H.

    2016-07-13

    Scientific reason for data generation: to serve as the reference case for the BT16 volume 1 agricultural scenarios. The agricultural baseline runs from 2015 through 2040; a starting year of 2014 is used. Date the data set was last modified: 02/12/2016 How each parameter was produced (methods), format, and relationship to other data in the data set: simulation was developed without offering a farmgate price to energy crops or residues (i.e., building on both the USDA 2015 baseline and the agricultural census data (USDA NASS 2014). Data generated are .txt output files by year, simulation identifier, county code (1-3109). Instruments used: POLYSYS (version POLYS2015_V10_alt_JAN22B) supplied by the University of Tennessee APAC The quality assurance and quality control that have been applied: • Check for negative planted area, harvested area, production, yield and cost values. • Check if harvested area exceeds planted area for annuals. • Check FIPS codes.

  4. Renormalization-group improved inflationary scenarios

    NASA Astrophysics Data System (ADS)

    Pozdeeva, E. O.; Vernov, S. Yu.

    2017-03-01

    The possibility to construct an inflationary scenario for renormalization-group improved potentials corresponding to the Higgs sector of quantum field models is investigated. Taking into account quantum corrections to the renormalization-group potential which sums all leading logs of perturbation theory is essential for a successful realization of the inflationary scenario, with very reasonable parameters values. The scalar electrodynamics inflationary scenario thus obtained are seen to be in good agreement with the most recent observational data.

  5. Transportation accident scenarios for commercial spent fuel

    SciTech Connect

    Wilmot, E L

    1981-02-01

    A spectrum of high severity, low probability, transportation accident scenarios involving commercial spent fuel is presented together with mechanisms, pathways and quantities of material that might be released from spent fuel to the environment. These scenarios are based on conclusions from a workshop, conducted in May 1980 to discuss transportation accident scenarios, in which a group of experts reviewed and critiqued available literature relating to spent fuel behavior and cask response in accidents.

  6. MIOSAT Mission Scenario and Design

    NASA Astrophysics Data System (ADS)

    Agostara, C.; Dionisio, C.; Sgroi, G.; di Salvo, A.

    2008-08-01

    MIOSAT ("Mssione Ottica su microSATellite") is a low-cost technological / scientific microsatellite mission for Earth Observation, funded by Italian Space Agency (ASI) and managed by a Group Agreement between Rheinmetall Italia - B.U. Spazio - Contraves as leader and Carlo Gavazzi Space as satellite manufacturer. Several others Italians Companies, SME and Universities are involved in the development team with crucial roles. MIOSAT is a microsatellite weighting around 120 kg and placed in a 525 km altitude sun-synchronuos circular LEO orbit. The microsatellite embarks three innovative optical payloads: Sagnac multi spectral radiometer (IFAC-CNR), Mach Zehender spectrometer (IMM-CNR), high resolution pancromatic camera (Selex Galileo). In addition three technological experiments will be tested in-flight. The first one is an heat pipe based on Marangoni effect with high efficiency. The second is a high accuracy Sun Sensor using COTS components and the last is a GNSS SW receiver that utilizes a Leon2 processor. Finally a new generation of 28% efficiency solar cells will be adopted for the power generation. The platform is highly agile and can tilt along and cross flight direction. The pointing accuracy is in the order of 0,1° for each axe. The pointing determination during images acquisition is <0,02° for the axis normal to the boresight and 0,04° for the boresight. This paper deals with MIOSAT mission scenario and definition, highlighting trade-offs for mission implementation. MIOSAT mission design has been constrained from challenging requirements in terms of satellite mass, mission lifetime, instrument performance, that have implied the utilization of satellite agility capability to improve instruments performance in terms of S/N and resolution. The instruments provide complementary measurements that can be combined in effective ways to exploit new applications in the fields of atmosphere composition analysis, Earth emissions, antropic phenomena, etc. The Mission

  7. From Scenarios to Test Implementations Via Promela

    NASA Astrophysics Data System (ADS)

    Ulrich, Andreas; Alikacem, El-Hachemi; Hallal, Hesham H.; Boroday, Sergiy

    We report on a tool for generating executable concurrent tests from scenarios specified as message sequence charts. The proposed approach features three steps: 1) Deriving a MSC test implementation from a MSC scenario, 2) Mapping the test implementation into a Promela model, 3) Generating executable test scripts in Java. The generation of an intermediate Promela model allows for model-checking to inspect the test implementation for properties like soundness, fault detection power as well as for consistency checking between different test scenarios. Moreover decoupling the executable test scripts from the scenario specification makes it possible to use different backend code generators to support other scripting languages when needed.

  8. Synchrony and motor mimicking in chimpanzee observational learning

    PubMed Central

    Fuhrmann, Delia; Ravignani, Andrea; Marshall-Pescini, Sarah; Whiten, Andrew

    2014-01-01

    Cumulative tool-based culture underwrote our species' evolutionary success, and tool-based nut-cracking is one of the strongest candidates for cultural transmission in our closest relatives, chimpanzees. However the social learning processes that may explain both the similarities and differences between the species remain unclear. A previous study of nut-cracking by initially naïve chimpanzees suggested that a learning chimpanzee holding no hammer nevertheless replicated hammering actions it witnessed. This observation has potentially important implications for the nature of the social learning processes and underlying motor coding involved. In the present study, model and observer actions were quantified frame-by-frame and analysed with stringent statistical methods, demonstrating synchrony between the observer's and model's movements, cross-correlation of these movements above chance level and a unidirectional transmission process from model to observer. These results provide the first quantitative evidence for motor mimicking underlain by motor coding in apes, with implications for mirror neuron function. PMID:24923651

  9. Mimicking Neural Stem Cell Niche by Biocompatible Substrates

    PubMed Central

    Regalado-Santiago, Citlalli; Juárez-Aguilar, Enrique; Olivares-Hernández, Juan David; Tamariz, Elisa

    2016-01-01

    Neural stem cells (NSCs) participate in the maintenance, repair, and regeneration of the central nervous system. During development, the primary NSCs are distributed along the ventricular zone of the neural tube, while, in adults, NSCs are mainly restricted to the subependymal layer of the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. The circumscribed areas where the NSCs are located contain the secreted proteins and extracellular matrix components that conform their niche. The interplay among the niche elements and NSCs determines the balance between stemness and differentiation, quiescence, and proliferation. The understanding of niche characteristics and how they regulate NSCs activity is critical to building in vitro models that include the relevant components of the in vivo niche and to developing neuroregenerative approaches that consider the extracellular environment of NSCs. This review aims to examine both the current knowledge on neurogenic niche and how it is being used to develop biocompatible substrates for the in vitro and in vivo mimicking of extracellular NSCs conditions. PMID:26880934

  10. Trastuzumab-Induced Myocardiotoxicity Mimicking Acute Coronary Syndrome

    PubMed Central

    Ribeiro, K.B.; Miranda, C.H.; Andrade, J.M.; Galli, L.G.; Tiezzi, D.G.; Oliveira, H.F.; Zola, F.E.; Volpe, G.; Pazin-Filho, A.; Peria, F.M.

    2012-01-01

    Trastuzumab is an important biological agent in the treatment of HER2-positive breast cancer, with effects on response rates, progression-free survival, overall survival and quality of life. Although this drug is well tolerated in terms of adverse effects, trastuzumab-associated myocardiotoxicity has been described to have an incidence of 0.6–4.5% and in rare cases, the drug can trigger severe congestive heart failure with progression to death or even mimic acute coronary syndrome with complete left bundle branch blockade. In this paper is reported a case of trastuzumab-associated myocardiotoxicity manifesting as acute coronary syndrome in a 69-year-old female. The patient is currently undergoing a conservative clinical treatment that restricts overexertion. The majority of clinical studies report trastuzumab-induced cardiotoxicity as a rare event, and, when present, characterized by mild to moderate clinical signs, the ease of reversibility with pharmacological measures and the temporary discontinuation of the medication. Conversely, it is vital for the oncologist/cardiologist to consider the possibility that trastuzumab-induced cardiotoxicity may manifest itself as a severe clinical case, mimicking acute coronary syndrome, justifying careful risk stratification and adequate cardiac monitoring, especially in high-risk patients. PMID:22666200

  11. Idiopathic Transverse Myelitis Mimicking an Intramedullary Spinal Cord Tumor

    PubMed Central

    Fanous, Andrew A.; Olszewski, Nathan P.; Lipinski, Lindsay J.; Qiu, Jingxin

    2016-01-01

    The differential diagnoses for spinal cord lesions include spinal tumors and inflammatory processes. The distinction between these pathologies can be difficult if solely based on imaging. We report for the first time to our knowledge a case of idiopathic transverse myelitis (ITM) mimicking a discrete cervical spinal lesion in a 66-year-old man who presented with gait instability and neck pain. The patient's symptoms failed to resolve after an initial course of steroid therapy. Surgical biopsy confirmed the diagnosis of ITM. Subsequent treatment with dexamethasone resulted in complete resolution of the symptoms as well as the intramedullary enhancement. ITM is most common in the cervical and thoracic spine, spanning 3-4 spinal segments. It usually occupies more than 50% of the cross-sectional area of the spinal cord and tends to be central, uniform, and symmetric. It exhibits patchy and peripheral contrast enhancement. These criteria are useful guidelines that help distinguish ITM from neoplastic spinal lesions. A decision to perform biopsy must take into consideration the patient's clinical symptoms, the rate of progression of neurological deficits, and the imaging characteristics of the lesion. Surgical biopsy for questionable lesions should be reserved for patients with progressive neurological deficits refractory to empirical medical therapy. PMID:27672469

  12. Acoustic resolution photoacoustic Doppler velocimetry in blood-mimicking fluids

    NASA Astrophysics Data System (ADS)

    Brunker, Joanna; Beard, Paul

    2016-02-01

    Photoacoustic Doppler velocimetry provides a major opportunity to overcome limitations of existing blood flow measuring methods. By enabling measurements with high spatial resolution several millimetres deep in tissue, it could probe microvascular blood flow abnormalities characteristic of many different diseases. Although previous work has demonstrated feasibility in solid phantoms, measurements in blood have proved significantly more challenging. This difficulty is commonly attributed to the requirement that the absorber spatial distribution is heterogeneous relative to the minimum detectable acoustic wavelength. By undertaking a rigorous study using blood-mimicking fluid suspensions of 3 μm absorbing microspheres, it was discovered that the perceived heterogeneity is not only limited by the intrinsic detector bandwidth; in addition, bandlimiting due to spatial averaging within the detector field-of-view also reduces perceived heterogeneity and compromises velocity measurement accuracy. These detrimental effects were found to be mitigated by high-pass filtering to select photoacoustic signal components associated with high heterogeneity. Measurement under-reading due to limited light penetration into the flow vessel was also observed. Accurate average velocity measurements were recovered using “range-gating”, which furthermore maps the cross-sectional velocity profile. These insights may help pave the way to deep-tissue non-invasive mapping of microvascular blood flow using photoacoustic methods.

  13. Acoustic resolution photoacoustic Doppler velocimetry in blood-mimicking fluids.

    PubMed

    Brunker, Joanna; Beard, Paul

    2016-02-19

    Photoacoustic Doppler velocimetry provides a major opportunity to overcome limitations of existing blood flow measuring methods. By enabling measurements with high spatial resolution several millimetres deep in tissue, it could probe microvascular blood flow abnormalities characteristic of many different diseases. Although previous work has demonstrated feasibility in solid phantoms, measurements in blood have proved significantly more challenging. This difficulty is commonly attributed to the requirement that the absorber spatial distribution is heterogeneous relative to the minimum detectable acoustic wavelength. By undertaking a rigorous study using blood-mimicking fluid suspensions of 3 μm absorbing microspheres, it was discovered that the perceived heterogeneity is not only limited by the intrinsic detector bandwidth; in addition, bandlimiting due to spatial averaging within the detector field-of-view also reduces perceived heterogeneity and compromises velocity measurement accuracy. These detrimental effects were found to be mitigated by high-pass filtering to select photoacoustic signal components associated with high heterogeneity. Measurement under-reading due to limited light penetration into the flow vessel was also observed. Accurate average velocity measurements were recovered using "range-gating", which furthermore maps the cross-sectional velocity profile. These insights may help pave the way to deep-tissue non-invasive mapping of microvascular blood flow using photoacoustic methods.

  14. Moderately nonlinear ultrasound propagation in blood-mimicking fluid.

    PubMed

    Kharin, Nikolay A; Vince, D Geoffrey

    2004-04-01

    In medical diagnostic ultrasound (US), higher than-in-water nonlinearity of body fluids and tissue usually does not produce strong nonlinearly distorted waves because of the high absorption. The relative influence of absorption and nonlinearity can be characterized by the Gol'dberg number Gamma. There are two limiting cases in nonlinear acoustics: weak waves (Gamma < 1) or strong waves (Gamma > 1). However, at diagnostic frequencies in tissue and body fluids, the nonlinear effects and effects of absorption more likely are comparable (Gol'dberg number Gamma approximately 1). The aim of this work was to study the nonlinear propagation of a moderately nonlinear US second harmonic signal in a blood-mimicking fluid. Quasilinear solutions to the KZK equation are presented, assuming radiation from a flat and geometrically focused circular Gaussian source. The solutions are expressed in a new simplified closed form and are in very good agreement with those of previous studies measuring and modeling Gaussian beams. The solutions also show good agreement with the measurements of the beams produced by commercially available transducers, even without special Gaussian shading.

  15. Idiopathic hypertrophic pachymeningitis mimicking prolactinoma with recurrent vision loss.

    PubMed

    Lok, Julie Y C; Yip, Nelson K F; Chong, Kelvin K L; Li, C L; Young, Alvin L

    2015-08-01

    Idiopathic hypertrophic pachymeningitis is a rare inflammatory condition with diffuse thickening of the dura mater, which may cause a compressive effect or vascular compromise. We report on a 28-year-old Chinese woman with a history of granulomatous mastitis 7 years previously and oligomenorrhoea, headache, blurred vision, and raised prolactin level 2 years previously, that was diagnosed as prolactinoma and treated conservatively with bromocriptine. However, she had recurrent bilateral vision loss when the bromocriptine was stopped. Her symptoms were resolved by high-dose steroid injection but remained steroid-dependent. Serial magnetic resonance imaging scan showed progressive diffuse thickening of the pachymeningitis with disappearance of pituitary apoplexy. Lumbar puncture showed lymphocytosis with no organisms. Open biopsy of the meninges was performed and histology showed features of inflammatory infiltrates and vasculitis. This is an unusual presentation of a rare condition in this age-group, with co-existing granulomatous mastitis and chronic otitis media, and is a diagnostic challenge mimicking pituitary macroadenoma and meningioma in initial magnetic resonance imaging scans.

  16. Extramedullary Plasmacytoma Mimicking Pancreatic Cancer: An Unusual Presentation

    PubMed Central

    Sciancalepore, Daniela; Musci, Sergio; Fracella, Maria Rosaria; D'Alesio, Grazia; Sportelli, Azzurra; Ingravallo, Giuseppe; Vacca, Angelo

    2016-01-01

    Multiple myeloma is a plasma cell tumor that homes to and expands in the bone marrow and that, despite the new available drugs, remains incurable. Extramedullary plasmacytoma is a not frequent manifestation during the natural history of multiple myeloma and is frequently associated with plasma cell bone marrow infiltration. The most common locations for an EMP include the gastrointestinal tract, pleura, testis, skin, peritoneum, liver, endocrine glands, and lymph nodes. Primary involvement of the gallbladder fossa is exceedingly rare. In this report, we describe a patient with multiple myeloma who achieved a clinical and serological remission after autologous transplant but progressed rapidly at extramedullary site mimicking a second cancer (i.e., pancreatic or biliary cancer). In this case, the extramedullary localization was refractory to standard therapy, differently from bone marrow localization, but responded to lymphoma-like therapy. In this patient (i) the particular site of developing plasmacytoma is the gallbladder fossa, (ii) the timing of onset of this neoplasm is immediately after autologous transplant, and (iii) its disjunction from primary myeloma is that it appears in clinical and serological remission phase which may be confounding during the diagnostic approach simulating a different tumor (solid tumor). PMID:27847663

  17. Mimicking static anisotropic fluid spheres in general relativity

    NASA Astrophysics Data System (ADS)

    Boonserm, Petarpa; Ngampitipan, Tritos; Visser, Matt

    2016-11-01

    We argue that an arbitrary general relativistic static anisotropic fluid sphere, (static and spherically symmetric but with transverse pressure not equal to radial pressure), can nevertheless be successfully mimicked by suitable linear combinations of theoretically attractive and quite simple classical matter: a classical (charged) isotropic perfect fluid, a classical electromagnetic field and a classical (minimally coupled) scalar field. While the most general decomposition is not unique, a preferred minimal decomposition can be constructed that is unique. We show how the classical energy conditions for the anisotropic fluid sphere can be related to energy conditions for the isotropic perfect fluid, electromagnetic field, and scalar field components of the model. Furthermore, we show how this decomposition relates to the distribution of both electric charge density and scalar charge density throughout the model. The generalized TOV equation implies that the perfect fluid component in this model is automatically in internal equilibrium, with pressure forces, electric forces, and scalar forces balancing the gravitational pseudo-force. Consequently, we can build theoretically attractive matter models that can be used to mimic almost any static spherically symmetric spacetime.

  18. Wernicke's Encephalopathy Mimicking Acute Onset Stroke Diagnosed by CT Perfusion

    PubMed Central

    Advani, Rajiv; Kurz, Kathinka D.; Kurz, Martin W.

    2014-01-01

    Background. Metabolic syndromes such as Wernicke's encephalopathy may present with a sudden neurological deficit, thus mimicking acute onset stroke. Due to current emphasis on rapid admission and treatment of acute stroke patients, there is a significant risk that these stroke mimics may end up being treated with thrombolysis. Rigorous clinical and radiological skills are necessary to correctly identify such metabolic stroke mimics, in order to avoid doing any harm to these patients due to the unnecessary use of thrombolysis. Patient. A 51-year-old Caucasian male was admitted to our hospital with suspicion of an acute stroke due to sudden onset dysarthria and unilateral facial nerve paresis. Clinical examination revealed confusion and dysconjugate gaze. Computed tomography (CT) including a CT perfusion (CTP) scan revealed bilateral thalamic hyperperfusion. The use of both clinical and radiological findings led to correctly diagnosing Wernicke's encephalopathy. Conclusion. The application of CTP as a standard diagnostic tool in acute stroke patients can improve the detection of stroke mimics caused by metabolic syndromes as shown in our case report. PMID:24716022

  19. Mimicking Oxygen delivery and waste removal functions of blood.

    PubMed

    Zhang, Huaifa; Barralet, Jake E

    2017-02-15

    In addition to immunological and wound healing cell and platelet delivery, ion stasis and nutrient supply, blood delivers oxygen to cells and tissues and removes metabolic wastes. For decades researchers have been trying to develop approaches that mimic these two immediately vital functions of blood. Oxygen is crucial for the long-term survival of tissues and cells in vertebrates. Hypoxia (oxygen deficiency) and even at times anoxia (absence of oxygen) can occur during organ preservation, organ and cell transplantation, wound healing, in tumors and engineering of tissues. Different approaches have been developed to deliver oxygen to tissues and cells, including hyperbaric oxygen therapy (HBOT), normobaric hyperoxia therapy (NBOT), using biochemical reactions and electrolysis, employing liquids with high oxygen solubility, administering hemoglobin, myoglobin and red blood cells (RBCs), introducing oxygen-generating agents, using oxygen-carrying microparticles, persufflation, and peritoneal oxygenation. Metabolic waste accumulation is another issue in biological systems when blood flow is insufficient. Metabolic wastes change the microenvironment of cells and tissues, influence the metabolic activities of cells, and ultimately cause cell death. This review examines advances in blood mimicking systems in the field of biomedical engineering in terms of oxygen delivery and metabolic waste removal.

  20. Riboswitch Structure: an Internal Residue Mimicking the Purine Ligand

    SciTech Connect

    Delfosse, V.; Bouchard, P; Bonneau, E; Dagenais, P; Lemay, J; Lafontaine, D; Legault, P

    2009-01-01

    The adenine and guanine riboswitches regulate gene expression in response to their purine ligand. X-ray structures of the aptamer moiety of these riboswitches are characterized by a compact fold in which the ligand forms a Watson-Crick base pair with residue 65. Phylogenetic analyses revealed a strict restriction at position 39 of the aptamer that prevents the G39-C65 and A39-U65 combinations, and mutational studies indicate that aptamers with these sequence combinations are impaired for ligand binding. In order to investigate the rationale for sequence conservation at residue 39, structural characterization of the U65C mutant from Bacillus subtilis pbuE adenine riboswitch aptamer was undertaken. NMR spectroscopy and X-ray crystallography studies demonstrate that the U65C mutant adopts a compact ligand-free structure, in which G39 occupies the ligand-binding site of purine riboswitch aptamers. These studies present a remarkable example of a mutant RNA aptamer that adopts a native-like fold by means of ligand mimicking and explain why this mutant is impaired for ligand binding. Furthermore, this work provides a specific insight into how the natural sequence has evolved through selection of nucleotide identities that contribute to formation of the ligand-bound state, but ensures that the ligand-free state remains in an active conformation.

  1. Multimodal 3D cancer-mimicking optical phantom

    PubMed Central

    Smith, Gennifer T.; Lurie, Kristen L.; Zlatev, Dimitar V.; Liao, Joseph C.; Ellerbee Bowden, Audrey K.

    2016-01-01

    Three-dimensional (3D) organ-mimicking phantoms provide realistic imaging environments for testing various aspects of optical systems, including for evaluating new probe designs, characterizing the diagnostic potential of new technologies, and assessing novel image processing algorithms prior to validation in real tissue. We introduce and characterize the use of a new material, Dragon Skin (Smooth-On Inc.), and fabrication technique, air-brushing, for fabrication of a 3D phantom that mimics the appearance of a real organ under multiple imaging modalities. We demonstrate the utility of the material and technique by fabricating the first 3D, hollow bladder phantom with realistic normal and multi-stage pathology features suitable for endoscopic detection using the gold standard imaging technique, white light cystoscopy (WLC), as well as the complementary imaging modalities of optical coherence tomography and blue light cystoscopy, which are aimed at improving the sensitivity and specificity of WLC to bladder cancer detection. The flexibility of the material and technique used for phantom construction allowed for the representation of a wide range of diseased tissue states, ranging from inflammation (benign) to high-grade cancerous lesions. Such phantoms can serve as important tools for trainee education and evaluation of new endoscopic instrumentation. PMID:26977369

  2. Hypoxia-Mimicking Nanofibrous Scaffolds Promote Endogenous Bone Regeneration.

    PubMed

    Yao, Qingqing; Liu, Yangxi; Tao, Jianning; Baumgarten, Keith M; Sun, Hongli

    2016-11-30

    Utilizing biomimetic materials to potentiate endogenous cell growth or signaling is superior to relying on exogenous cells or signals for bone formation. Desferoxamine (DFO), which is a hypoxia-mimetic agent that chelates iron (Fe(3+)), mimics hypoxia to encourage bone healing. However, high cytotoxicity, off-target effects, and the short half-life of DFO have significantly impeded its further applications. We mitigated these side effects by locally immobilizing DFO onto a gelatin nanofibrous (GF) scaffold that retained DFO's ability to chelate Fe(3+). Moreover, DFO-functionalized GF (GF-DFO) scaffolds, which have similar micro/macrostructures to GF scaffolds, not only demonstrated decreased cytotoxicity on both human umbilical vein endothelial cells and human mesenchymal stem cells but also significantly increased vascular endothelial growth factor (VEGF) expression in vitro. Most importantly, in our in vivo experiments on a critical-sized cranial bone defect mouse model, a significant amount of bone was formed in most of the GF-DFO scaffolds after six weeks, while very little new bone was observed in the GF scaffolds. These data suggest that use of a hypoxia-mimicking nanofibrous scaffold is a promising strategy for promoting endogenous bone formation.

  3. Quadrivalvular marantic endocarditis (ME) mimicking acute bacterial endocarditis (ABE).

    PubMed

    Durie, Nicole M; Eisenstein, Lawrence E; Cunha, Burke A; Plummer, Maria Maratta

    2007-01-01

    Marantic endocarditis (ME) is defined by noninfectious valvular vegetations. The most common disorders associated with ME are malignancy with or without hypercoagulable state, intercardiac instrumentation, residual vegetations from previously treated infective endocarditis (IE), renal insufficiency, and burns. Another important cause of ME is systemic lupus erythematosus when accompanied by vegetations, that is, Libman-Sacks endocarditis. ME should be differentiated from IE because they may present with similar clinical features. Both ME and IE may present with fever and a heart murmur with or without embolic phenomenon. Leukocytosis and elevated erythrocyte sedimentation rate suggest the diagnosis of IE. The hallmark of IE is a cardiac vegetation and continuous high-grade bacteremia. After exclusion of the causes of culture negative endocarditis, the absence of bacteremia clearly differentiates ME from IE. We present a case of ME mimicking acute bacterial endocarditis (ABE). The differential diagnostic features of ME versus IE are discussed. To the best of our knowledge, this is the first reported case of quadrivalvular ME with massive vegetations on all cardiac valves, as well as the aorta, atria, and pulmonary artery.

  4. Auditory-motor entrainment in vocal mimicking species

    PubMed Central

    2010-01-01

    We have recently found robust evidence of motor entrainment to auditory stimuli in multiple species of non-human animal, all of which were capable of vocal mimicry. In contrast, the ability remained markedly absent in many closely related species incapable of vocal mimicry. This suggests that vocal mimicry may be a necessary precondition for entrainment. However, within the vocal mimicking species, entrainment appeared non-randomly, suggesting that other components besides vocal mimicry play a role in the capacity and tendency to entrain. Here we discuss potential additional factors involved in entrainment. New survey data show that both male and female parrots are able to entrain, and that the entrainment capacity appears throughout the lifespan. We suggest routes for future study of entrainment, including both developmental studies in species known to entrain and further work to detect entrainment in species not well represented in our dataset. These studies may shed light on additional factors necessary for entrainment in addition to vocal mimicry. PMID:20714417

  5. Acoustic resolution photoacoustic Doppler velocimetry in blood-mimicking fluids

    PubMed Central

    Brunker, Joanna; Beard, Paul

    2016-01-01

    Photoacoustic Doppler velocimetry provides a major opportunity to overcome limitations of existing blood flow measuring methods. By enabling measurements with high spatial resolution several millimetres deep in tissue, it could probe microvascular blood flow abnormalities characteristic of many different diseases. Although previous work has demonstrated feasibility in solid phantoms, measurements in blood have proved significantly more challenging. This difficulty is commonly attributed to the requirement that the absorber spatial distribution is heterogeneous relative to the minimum detectable acoustic wavelength. By undertaking a rigorous study using blood-mimicking fluid suspensions of 3 μm absorbing microspheres, it was discovered that the perceived heterogeneity is not only limited by the intrinsic detector bandwidth; in addition, bandlimiting due to spatial averaging within the detector field-of-view also reduces perceived heterogeneity and compromises velocity measurement accuracy. These detrimental effects were found to be mitigated by high-pass filtering to select photoacoustic signal components associated with high heterogeneity. Measurement under-reading due to limited light penetration into the flow vessel was also observed. Accurate average velocity measurements were recovered using “range-gating”, which furthermore maps the cross-sectional velocity profile. These insights may help pave the way to deep-tissue non-invasive mapping of microvascular blood flow using photoacoustic methods. PMID:26892989

  6. Mimicking the magnetic properties of rare earth elements using superatoms.

    PubMed

    Cheng, Shi-Bo; Berkdemir, Cuneyt; Castleman, A W

    2015-04-21

    Rare earth elements (REs) consist of a very important group in the periodic table that is vital to many modern technologies. The mining process, however, is extremely damaging to the environment, making them low yield and very expensive. Therefore, mimicking the properties of REs in a superatom framework is especially valuable but at the same time, technically challenging and requiring advanced concepts about manipulating properties of atom/molecular complexes. Herein, by using photoelectron imaging spectroscopy, we provide original idea and direct experimental evidence that chosen boron-doped clusters could mimic the magnetic characteristics of REs. Specifically, the neutral LaB and NdB clusters are found to have similar unpaired electrons and magnetic moments as their isovalent REs (namely Nd and Eu, respectively), opening up the great possibility in accomplishing rare earth mimicry. Extension of the superatom concept into the rare earth group not only further shows the power and advance of this concept but also, will stimulate more efforts to explore new superatomic clusters to mimic the chemistry of these heavy atoms, which will be of great importance in designing novel building blocks in the application of cluster-assembled nanomaterials. Additionally, based on these experimental findings, a novel "magic boron" counting rule is proposed to estimate the numbers of unpaired electrons in diatomic LnB clusters.

  7. Pulmonary Actinomycosis Mimicking Pulmonary Aspergilloma and a Brief Review of the Literature

    PubMed Central

    Higashi, Yoshitsugu; Nakamura, Shigeki; Ashizawa, Nobuyuki; Oshima, Kazuhiro; Tanaka, Akitaka; Miyazaki, Taiga; Izumikawa, Koichi; Yanagihara, Katsunori; Yamamoto, Yoshihiro; Miyazaki, Yoshitsugu; Mukae, Hiroshi; Kohno, Shigeru

    2017-01-01

    Pulmonary actinomycosis is a rare pulmonary infection that often exhibits unspecific symptoms and radiological findings. We herein report a case of pulmonary actinomycosis that mimicked pulmonary aspergilloma in an immunocompetent patient. PMID:28202870

  8. Scenario-based assessment of buildings' damage and population exposure due to earthquake-induced tsunamis for the town of Alexandria, Egypt

    NASA Astrophysics Data System (ADS)

    Pagnoni, G.; Armigliato, A.; Tinti, S.

    2015-12-01

    Alexandria is the second biggest city in Egypt with regards to population, is a key economic area in northern Africa and has very important tourist activity. Historical records indicate that it was severely affected by a number of tsunami events. In this work we assess the tsunami hazard by running numerical simulations of tsunami impact in Alexandria through the worst-case credible tsunami scenario analysis (WCTSA). We identify three main seismic sources: the western Hellenic Arc (WHA - reference event AD 365, Mw = 8.5), the eastern Hellenic Arc (EHA - reference event 1303, Mw = 8.0) and the Cyprus Arc (CA - hypothetical scenario earthquake with Mw = 8.0), inferred from the tectonic setting and from historical tsunami catalogues. All numerical simulations are carried out in two sea level conditions (mean sea level and maximum high-tide sea level) by means of the code UBO-TSUFD, developed and maintained by the Tsunami Research Team of the University of Bologna. Relevant tsunami metrics are computed for each scenario and then used to build aggregated fields such as the maximum flood depth and the maximum inundation area. We find that the case that produces the most relevant flooding in Alexandria is the EHA scenario, with wave heights up to 4 m. The aggregate fields are used for a building vulnerability assessment according to a methodology developed in the framework of the EU-FP6 project SCHEMA and further refined in this study, based on the adoption of a suitable building damage matrix and on water inundation depth. It is found that in the districts of El Dekhila and Al Amriyah, to the south-west of the port of Dekhila, over 12 000 (13 400 in the case of maximum high tide) buildings could be affected and hundreds of them could sustain damaging consequences, ranging from critical damage to total collapse. It is also found that in the same districts tsunami inundation covers an area of about 15 km2, resulting in more than 150 000 (165 000 in the case of maximum high

  9. Uncertainty in Integrated Assessment Scenarios

    SciTech Connect

    Mort Webster

    2005-10-17

    trends from a model for uncertainty projections. The probability distributions of these critical model drivers, and the resulting uncertainty in projections from a range of models, can provide the basis of future emission scenario set designs.

  10. Measurement of guided mode wavenumbers in soft tissue-bone mimicking phantoms using ultrasonic axial transmission

    NASA Astrophysics Data System (ADS)

    Chen, Jiangang; Foiret, Josquin; Minonzio, Jean-Gabriel; Talmant, Maryline; Su, Zhongqing; Cheng, Li; Laugier, Pascal

    2012-05-01

    Human soft tissue is an important factor that influences the assessment of human long bones using quantitative ultrasound techniques. To investigate such influence, a series of soft tissue-bone phantoms (a bone-mimicking plate coated with a layer of water, glycerol or silicon rubber) were ultrasonically investigated using a probe with multi-emitter and multi-receiver arrays in an axial transmission configuration. A singular value decomposition signal processing technique was applied to extract the frequency-dependent wavenumbers of several guided modes. The results indicate that the presence of a soft tissue-mimicking layer introduces additional guided modes predicted by a fluid waveguide model. The modes propagating in the bone-mimicking plate covered by the soft-tissue phantom are only slightly modified compared to their counterparts in the free bone-mimicking plate, and they are still predicted by an elastic transverse isotropic two-dimensional waveguide. Altogether these observations suggest that the soft tissue-bone phantoms can be modeled as two independent waveguides. Even in the presence of the overlying soft tissue-mimicking layer, the modes propagating in the bone-mimicking plate can still be extracted and identified. These results suggest that our approach can be applied for the purpose of the characterization of the material and structural properties of cortical bone.

  11. Evaluation Framework for Dependable Mobile Learning Scenarios

    ERIC Educational Resources Information Center

    Bensassi, Manel; Laroussi, Mona

    2014-01-01

    The goal of the dependability analysis is to predict inconsistencies and to reveal ambiguities and incompleteness in the designed learning scenario. Evaluation, in traditional learning design, is generally planned after the execution of the scenario. In mobile learning, this stage becomes too difficult and expensive to apply due to the complexity…

  12. Scenario Planning at College of Marin.

    ERIC Educational Resources Information Center

    College of Marin, Kentfield, CA.

    This article reviews the scenario planning process implemented at the College of Marin (California). Scenario planning is a creative process in which a group of people who share a common fate develop stories about different ways their future might unfold, and use these stories to make decisions about what path to take. The Global Business Network…

  13. Multimedia Scenario in a Primary School

    ERIC Educational Resources Information Center

    Nulden, Urban; Ward, Bodil

    2002-01-01

    Multimedia as an educational technology tool is used throughout the educational system. In this article we present a research project where multimedia scenario was used to initiate a discussion about Internet use among students and teachers at a primary school. Multimedia scenario is the use of large screen multimedia to initiate and facilitate…

  14. Architectures for Developing Multiuser, Immersive Learning Scenarios

    ERIC Educational Resources Information Center

    Nadolski, Rob J.; Hummel, Hans G. K.; Slootmaker, Aad; van der Vegt, Wim

    2012-01-01

    Multiuser immersive learning scenarios hold strong potential for lifelong learning as they can support the acquisition of higher order skills in an effective, efficient, and attractive way. Existing virtual worlds, game development platforms, and game engines only partly cater for the proliferation of such learning scenarios as they are often…

  15. Molecular Diagnostic Analysis of Outbreak Scenarios

    ERIC Educational Resources Information Center

    Morsink, M. C.; Dekter, H. E.; Dirks-Mulder, A.; van Leeuwen, W. B.

    2012-01-01

    In the current laboratory assignment, technical aspects of the polymerase chain reaction (PCR) are integrated in the context of six different bacterial outbreak scenarios. The "Enterobacterial Repetitive Intergenic Consensus Sequence" (ERIC) PCR was used to analyze different outbreak scenarios. First, groups of 2-4 students determined optimal…

  16. Writing clinical scenarios for clinical science questions.

    PubMed

    Smith, Phil Em; Mucklow, John C

    2016-04-01

    Written knowledge assessments for physicians in training typically involve multiple-choice questions that use a clinical scenario in a single-best-answer format. The Royal College of Physicians Part 1 MRCP(UK) examination includes basic sciences themes that are challenging to assess through a clinical scenario. A realistic clinical setting based on everyday clinical practice and integral to the question is the clearest demonstration that the knowledge being assessed is clinically relevant. However, without special attention to detail, the scenario in a clinical science question can appear redundant or artificial. Reading unnecessary material frustrates candidates and threatens the reputation of the assessment. In this paper we discuss why a clinical scenario is important for basic science questions and offer advice on setting realistic and plausible clinical scenarios for such questions.

  17. Mimicking Photosynthesis with Electrode-Supported Lipid Nanoassemblies.

    PubMed

    Wang, Mingming; Zhan, Wei

    2016-11-15

    as well as their sequential formation on electrodes. Supported on electrodes, these bilayers uniformly afford reliable photocurrent generation and modular system design. (2) Gold-supported hybrid bilayers as a powerful model platform for probing biomembrane-associated photoelectrochemical processes. These hybrid nanostructures consist of one alkanethiol (or substituted alkanethiol) and one lipid monolayer, whose chemical identity and makeup can be separately controlled and modified. Such precise molecular organization and flexible formation, in turn, enable a series of physicochemical parameters key to photosynthetic processes to be explicitly examined and cross-compared. A few such examples, based on donor/acceptor distance and loading, interfacial dipole, and redox level, are included here to illustrate the usefulness and versatility of this system. (3) Mimicking photosynthesis with supercomplexed lipid nanoassemblies. This research effort was motivated to address the low light absorption suffered by single-bilayer based photosynthetic mimics and has yielded a new lipid-based approach to mimicking Nature's way of organizing multiple photosynthetic subunits. Rhodamine and fullerene assembled within these lipid supercomplexes display robust electronic communication. The remarkable possibility of using lipid matrix to further improve photoconversion efficiency is revealed by cholesterol, whose addition triggers exciton formation that promotes faster energy and electron transfer in these lipid nanoassemblies.

  18. Isolated neurosarcoidosis mimicking multifocal meningiomas: a diagnosis pitfall

    PubMed Central

    Wang, Kun; He, Xiaoying; Wang, Wei; Niu, Huanjiang; Wang, Yirong; Cai, Xiujun; Yang, Shuxu

    2016-01-01

    Abstract Introduction: Neurosarcoidosis accounts for approximately 5% of the sarcoidosis, which develops exclusively in the nervous system and is always difficult to diagnose. We describe a rare case of isolated neurosarcoidosis mimicking as multifocal meningiomas. A 27-year-old male was admitted to our hospital with a history of unconsciousness and convulsion 1 month ago, which was suspected as a seizure. The results showed no abnormalities in complete blood count; serum electrolytes; erythrocyte sedimentation rate and ultrasonography of the liver, pancreas, spleen, kidney and parotid gland, and so on. Chest radiograph and electroencephalogram were also normal. Serum-angiotensin-converting enzyme slightly increased. Normal opening pressure was shown in cerebrospinal fluid sampling, which includes 8/μL white blood cells, 0.93 g/L protein, and 3.03 mmol/L glucose. Enhanced magnetic resonance imaging revealed multifocal enhancement lesions, including left sphenoid wing region, left temporal and bilateral occipitoparietal region, which were suspected as multiple “meningioma”. A left frontotemporal craniotomy was further performed. Both necrotizing and non-necrotizing granulomas were revealed in the pathological specimen, most of which were associated with multinucleated giant cells and macrophages. We could also see the fibrosis and inflammatory reaction in the sample composed of lymphocytes, histiocytes, and plasma cells. Histopathological examination showed that the cells were positive for human CD68 (KP1), CD68 (PGM1), and CD163; however, they were negative for the AF, epithelial membrane antigen, and glial fibrillary acidic protein. Tuberculosis-deoxyribonucleic acid test and special stains for acid-fast bacilli and fungi were negative. The diagnosis was finally made as isolated neurosarcoidosis. Then the patient was treated with additional corticosteroid therapy. Serial imaging examination 4 months later revealed that the lesions extremely decreased

  19. Fate of pathogenic bacteria in microcosms mimicking human body sites.

    PubMed

    Castellani, Francesco; Ghidini, Valentina; Tafi, Maria Carla; Boaretti, Marzia; Lleo, Maria M

    2013-07-01

    During the infectious process, pathogens may reach anatomical sites where they are exposed to substances interfering with their growth. These substances can include molecules produced by the host, and his resident microbial population, as well as exogenous antibacterial drugs. Suboptimal concentrations of inhibitory molecules and stress conditions found in vivo (high or low temperatures, lack of oxygen, extreme pH) might induce in bacteria the activation of survival mechanisms blocking their division capability but allowing them to stay alive. These "dormant" bacteria can be reactivated in particular circumstances and would be able to express their virulence traits. In this study, it was evaluated the effect of some environmental conditions, such as optimal and suboptimal temperatures, direct light and antibiotic sub-inhibitory concentrations doses of antibiotic, on the human pathogens Escherichia coli and Enterococcus faecalis when incubated in fluids accumulated in the body of patients with different pathologies. It is shown that inoculation in a number of accumulated body fluids and the presence of gentamicin, reliable conditions encountered during pathological states, induce stress-responding strategies enabling bacteria to persist in microcosms mimicking the human body. Significant differences were detected in Gram-negative and Gram-positive species with E. faecalis surviving, as starved or viable but non-culturable forms, in any microcosm and condition tested and E. coli activating a viable but non-culturable state only in some clinical samples. The persistence of bacteria under these conditions, being non-culturable, might explain some recurrent infections without isolation of the causative agent after application of the standard microbiological methods.

  20. Kawasaki disease mimicking a parapharyngeal abscess: a case report.

    PubMed

    Cai, Qianyun; Luo, Rong; Gan, Jing; Zhang, Li; Qu, Yi; Mu, Dezhi

    2015-05-01

    Parapharyngeal abscess (PPA)-like lesion is a very rare manifestation of Kawasaki disease (KD). Here we report a Chinese case of KD initially mimicking PPA, which is the first one reported in Asia.A 3-year-old male patient presented with fever, drooling, and bilateral painful cervical lymphadenopathy for 3 days. Chest X-ray and echocardiogram were normal. With substantial elevation of white blood count and C-reactive protein, purulent cervical lymphadenitis was considered. Symptoms did not improve after treatment with vancomycin, and the patient further developed trismus and restricted neck movement. Neck CT revealed a 2 × 1.5 cm hypodense lesion in the right parapharyngeal space with peripheral enhancement. PPA was suspected and on the 3rd day following admission, the patient received surgical incision and drainage. One milliliter of serous fluid was drained without bacterial growth on cultures. Fever persisted after surgery. As the clinical course proceeded, additional major signs of KD gradually evolved, and on the 6th day following admission the patient completely fulfilled the diagnostic criteria for KD. Rapid clinical improvement was observed following treatment with high-dose immunoglobulin and aspirin. Due to the parapharyngeal operation, the patient was fed milk through a nasogastric tube for 15 days. His neck incision became infected but healed gradually following dressing change and antibiotic treatment. Currently he remains asymptomatic during regular follow-up and repeated echocardiograms are normal.Both pediatricians and otolaryngologists can learn from this case that KD may initially manifest as PPA. Careful observation for major signs of KD during the clinical course can help to achieve a prompt and correct diagnosis. Thus, unnecessary surgery and cardiac complications of KD may be avoided.

  1. Scripting Scenarios for the Human Patient Simulator

    NASA Technical Reports Server (NTRS)

    Bacal, Kira; Miller, Robert; Doerr, Harold

    2004-01-01

    The Human Patient Simulator (HPS) is particularly useful in providing scenario-based learning which can be tailored to fit specific scenarios and which can be modified in realtime to enhance the teaching environment. Scripting these scenarios so as to maximize learning requires certain skills, in order to ensure that a change in student performance, understanding, critical thinking, and/or communication skills results. Methods: A "good" scenario can be defined in terms of applicability, learning opportunities, student interest, and clearly associated metrics. Obstacles to such a scenario include a lack of understanding of the applicable environment by the scenario author(s), a desire (common among novices) to cover too many topics, failure to define learning objectives, mutually exclusive or confusing learning objectives, unskilled instructors, poor preparation , disorganized approach, or an inappropriate teaching philosophy (such as "trial by fire" or education through humiliation). Results: Descriptions of several successful teaching programs, used in the military, civilian, and NASA medical environments , will be provided, along with sample scenarios. Discussion: Simulator-based lessons have proven to be a time- and cost-efficient manner by which to educate medical personnel. Particularly when training for medical care in austere environments (pre-hospital, aeromedical transport, International Space Station, military operations), the HPS can enhance the learning experience.

  2. Interactive specification acquisition via scenarios: A proposal

    NASA Technical Reports Server (NTRS)

    Hall, Robert J.

    1992-01-01

    Some reactive systems are most naturally specified by giving large collections of behavior scenarios. These collections not only specify the behavior of the system, but also provide good test suites for validating the implemented system. Due to the complexity of the systems and the number of scenarios, however, it appears that automated assistance is necessary to make this software development process workable. Interactive Specification Acquisition Tool (ISAT) is a proposed interactive system for supporting the acquisition and maintenance of a formal system specification from scenarios, as well as automatic synthesis of control code and automated test generation. This paper discusses the background, motivation, proposed functions, and implementation status of ISAT.

  3. Vocational training: the case scenario workshop.

    PubMed

    Winter-Moore, P H

    2001-01-01

    This article describes the procedure for conducting a workshop for a vocational training group, using six clinical case scenarios harvested from the vocational training group's own experience. During the session, the main group (which includes trainers) breaks up into smaller groups to discuss the management of each case, then a spokesperson presents the management solutions back to the re-assembled larger group: further interaction and discussion then takes place. This article discusses six typical case scenarios from a recent workshop. The case scenario workshop is an exciting way to encourage discussion and interaction with all parties involved.

  4. Common Criteria Based Security Scenario Verification

    NASA Astrophysics Data System (ADS)

    Ohnishi, Atsushi

    Software is required to comply with the laws and standards of software security. However, stakeholders with less concern regarding security can neither describe the behaviour of the system with regard to security nor validate the system’s behaviour when the security function conflicts with usability. Scenarios or use-case specifications are common in requirements elicitation and are useful to analyze the usability of the system from a behavioural point of view. In this paper, the authors propose both (1) a scenario language based on a simple case grammar and (2) a method to verify a scenario with rules based on security evaluation criteria.

  5. FUTURE SCENARIOS OF CHANGE IN WILDLIFE HABITAT

    EPA Science Inventory

    Studies in Pennsylvania, Iowa, California, and Oregon show varying losses of terrestrial wildlife habitat in scenarios based on different assumptions about future human land use patterns. Retrospective estimates of losses of habitat since Euro-American settlement in several stud...

  6. Development and Validation of Videotaped Scenarios

    PubMed Central

    Noel, Nora E.; Maisto, Stephen A.; Johnson, James D.; Jackson, Lee A.; Goings, Christopher D.; Hagman, Brett T.

    2013-01-01

    Researchers using scenarios often neglect to validate perceived content and salience of embedded stimuli specifically with intended participants, even when such meaning is integral to the study. For example, sex and aggression stimuli are heavily influenced by culture, so participants may not perceive what researchers intended in sexual aggression scenarios. Using four studies, the authors describe the method of scenario validation to produce two videos assessing alcohol-related sexual aggression. Both videos are identical except for the presence in one video of antiforce cues that are extremely salient to the young heterosexual men. Focus groups and questionnaires validate these men's perceptions that (a) the woman was sexually interested, (b) the sexual cues were salient, (c) the antiforce cues were salient (antiaggression video only), and (e) these antiforce cues inhibited acceptance of forced sex. Results show the value of carefully selecting and validating content when assessing socially volatile variables and provide a useful template for developing culturally valid scenarios. PMID:18252938

  7. Combination of Face Regions in Forensic Scenarios.

    PubMed

    Tome, Pedro; Fierrez, Julian; Vera-Rodriguez, Ruben; Ortega-Garcia, Javier

    2015-07-01

    This article presents an experimental analysis of the combination of different regions of the human face on various forensic scenarios to generate scientific knowledge useful for the forensic experts. Three scenarios of interest at different distances are considered comparing mugshot and CCTV face images using MORPH and SC face databases. One of the main findings is that inner facial regions combine better in mugshot and close CCTV scenarios and outer facial regions combine better in far CCTV scenarios. This means, that depending of the acquisition distance, the discriminative power of the facial regions change, having in some cases better performance than the full face. This effect can be exploited by considering the fusion of facial regions which results in a very significant improvement of the discriminative performance compared to just using the full face.

  8. Model Performance Evaluation and Scenario Analysis (MPESA)

    EPA Pesticide Factsheets

    Model Performance Evaluation and Scenario Analysis (MPESA) assesses the performance with which models predict time series data. The tool was developed Hydrological Simulation Program-Fortran (HSPF) and the Stormwater Management Model (SWMM)

  9. Group 1: Scenario design and development issues

    NASA Technical Reports Server (NTRS)

    Sherwin, P.

    1981-01-01

    All LOFT scenarios and flight segments should be designed on the basis of a detailed statement of specific objectives. These objectives must state what kind of situation is to be addressed and why. The origin, routing, and destination of a particular scenario should be dictated by the specific objectives for that scenario or leg. Other factors to be considered are the desired weather, climate, etc. Simulator visual system, as well as other capabilities and limitations must be considered at a very early stage of scenario design. The simulator navigation area must be apropriate and must coincide with current Jeppeson charts. Much of the realism of LOFT is destroyed if the crew is unable to use current manuals and other materials.

  10. Fork-tailed drongos use deceptive mimicked alarm calls to steal food.

    PubMed

    Flower, Tom

    2011-05-22

    Despite the prevalence of vocal mimicry in animals, few functions for this behaviour have been shown. I propose a novel hypothesis that false mimicked alarm calls could be used deceptively to scare other species and steal their food. Studies have previously suggested that animals use their own species-specific alarm calls to steal food. However none have shown conclusively that these false alarms are deceptive, or that mimicked alarm calls are used in this manner. Here, I show that wild fork-tailed drongos (Dicrurus adsimilis) make both drongo-specific and mimicked false alarm calls when watching target species handling food, in response to which targets flee to cover abandoning their food. The drongo-specific and mimicked calls made in false alarms were structurally indistinguishable from calls made during true alarms at predators by drongos and other species. Furthermore, I demonstrate by playback experiments that two of these species, meerkats (Suricata suricatta) and pied babblers (Turdoides bicolor), are deceived by both drongo-specific and mimicked false alarm calls. These results provide the first conclusive evidence that false alarm calls are deceptive and demonstrate a novel function for vocal mimicry. This work also provides valuable insight into the benefits of deploying variable mimetic signals in deceptive communication.

  11. Development of Stepwise Osteogenesis-mimicking Matrices for the Regulation of Mesenchymal Stem Cell Functions*

    PubMed Central

    Hoshiba, Takashi; Kawazoe, Naoki; Tateishi, Tetsuya; Chen, Guoping

    2009-01-01

    An extracellular microenvironment, including an extracellular matrix (ECM), is an important factor in regulating stem cell differentiation. During tissue development, the ECM is dynamically remodeled to regulate stem cell functions. Here, we developed matrices mimicking ECM remodeling during the osteogenesis of mesenchymal stem cells (MSCs). The matrices were prepared from cultured MSCs controlled at different stages of osteogenesis and referred to as “stepwise osteogenesis-mimicking matrices.” The matrices supported the adhesion and proliferation of MSCs and showed different effects on the osteogenesis of MSCs. On the matrices mimicking the early stage of osteogenesis (early stage matrices), the osteogenesis occurred more rapidly than did that on the matrices mimicking undifferentiated stem cells (stem cell matrices) and the late stage of osteogenesis (late stage matrices). RUNX2 was similarly expressed when MSCs were cultured on both the early stage and late stage matrices but decreased on the stem cell matrices. PPARG expression in the MSCs cultured on the late stage matrices was higher than for those cultured on the stem cell and early stage matrices. This increase of PPARG expression was caused by the suppression of the amount of β-catenin and downstream signal transduction. These results demonstrate that the osteogenesis-mimicking matrices had different effects on the osteogenesis of MSCs, and the early stage matrices provided a favorable microenvironment for the osteogenesis. PMID:19762920

  12. Subsistence Exposure Scenarios for Tribal Applications

    PubMed Central

    Harper, Barbara; Harding, Anna; Harris, Stuart; Berger, Patricia

    2014-01-01

    The article provides an overview of methods that can be used to develop exposure scenarios for unique tribal natural resource usage patterns. Exposure scenarios are used to evaluate the degree of environmental contact experienced by people with different patterns of lifestyle activities, such as residence, recreation, or work. in 1994, U.S. President Bill Clinton's Executive Order 12898 recognized that disproportionately high exposures could be incurred by people with traditional subsistence lifestyles because of their more intensive contact with natural resources. Since then, we have developed several tribal exposure scenarios that reflect tribal-specific traditional lifeways. These scenarios are not necessarily intended to capture contemporary resource patterns, but to describe how the resources were used before contamination or degradation, and will be used once again in fully traditional ways after cleanup and restoration. The direct exposure factors for inhalation and soil ingestion rates are the same in each tribal scenario, but the diets are unique to each tribe and its local ecology, natural foods, and traditional practices. Scenarios, in part or in whole, also have other applications, such as developing environmental standards, evaluating disproportionate exposures, developing sampling plans, planning for climate change, or evaluating service flows as part of natural resource damage assessments. PMID:25197207

  13. Modeling post-fire sediment yield based on two burn scenarios at the Sooke Lake Reservoir, BC, Canada

    NASA Astrophysics Data System (ADS)

    Dobre, Mariana; Elliot, William J.; Brooks, Erin S.; Smith, Tim

    2016-04-01

    the winter when the soils are not water repellant. The erosion rates varied from 0.34 tonnes/ha/year to 37.3 tonnes/ha/year with the most vulnerable slopes being those associated with steep shallow soils. The summation of the 10-year return period annual delivered sediment from all the watersheds for the worst case scenario during winter months is 17% greater than the total sediment delivery for the real case scenarios. Despite the data limitations, this analysis provides insight into the critical watersheds that will be major source areas of sediment following a wildfire. Watershed managers can use this information to plan and prioritize post-wildfire rehabilitation strategies and actions to minimize the risk of sediment delivery from the hillslopes that generate the greatest amount of sediment.

  14. Acute tuberculous myopericarditis mimicking acute myocardial infarction: A case report and literature review

    PubMed Central

    REN, MANYI; ZHANG, CHUNSHENG; ZHANG, XIAOJUAN; ZHONG, JINGQUAN

    2016-01-01

    A number of cases of acute myopericarditis mimicking acute myocardial infarction (AMI) have previously been reported in the literature. However, to the best of our knowledge, such a case resulting from Mycobacterium tuberculosis infection has not previously been described. The present study reports the case of a 21-year-old male patient presenting with acute chest pain, in whom focal ST-segment elevation and elevated cardiac enzymes mimicked a diagnosis of AMI. However, acute tuberculous myopericarditis was diagnosed on the basis of a variety of imaging examinations, laboratory tests, as well as the changes observed in electrocardiograms (ECGs) and in the cardiac enzyme levels. The case highlights the importance of a detailed collection of medical history, comprehensive explanations of serial ECGs, thoracic computed tomography, echocardiogram and coronary angiography in the diagnosis and differentiation of acute tuberculous myopericarditis mimicking AMI. PMID:27284323

  15. Polymerization of a divalent/tetravalent metal-storing atom-mimicking dendrimer

    PubMed Central

    Albrecht, Ken; Hirabayashi, Yuki; Otake, Masaya; Mendori, Shin; Tobari, Yuta; Azuma, Yasuo; Majima, Yutaka; Yamamoto, Kimihisa

    2016-01-01

    The phenylazomethine dendrimer (DPA) has a layer-by-layer electron density gradient that is an analog of the Bohr atom (atom mimicry). In combination with electron pair mimicry, the polymerization of this atom-mimicking dendrimer was achieved. The valency of the mimicked atom was controlled by changing the chemical structure of the dendrimer. By mimicking a divalent atom, a one-dimensional (1D) polymer was obtained, and by using a planar tetravalent atom mimic, a 2D polymer was obtained. These poly(dendrimer) polymers could store Lewis acids (SnCl2) in their unoccupied orbitals, thus indicating that these poly(dendrimer) polymers consist of a series of nanocontainers. PMID:27957538

  16. Polymerization of a divalent/tetravalent metal-storing atom-mimicking dendrimer.

    PubMed

    Albrecht, Ken; Hirabayashi, Yuki; Otake, Masaya; Mendori, Shin; Tobari, Yuta; Azuma, Yasuo; Majima, Yutaka; Yamamoto, Kimihisa

    2016-12-01

    The phenylazomethine dendrimer (DPA) has a layer-by-layer electron density gradient that is an analog of the Bohr atom (atom mimicry). In combination with electron pair mimicry, the polymerization of this atom-mimicking dendrimer was achieved. The valency of the mimicked atom was controlled by changing the chemical structure of the dendrimer. By mimicking a divalent atom, a one-dimensional (1D) polymer was obtained, and by using a planar tetravalent atom mimic, a 2D polymer was obtained. These poly(dendrimer) polymers could store Lewis acids (SnCl2) in their unoccupied orbitals, thus indicating that these poly(dendrimer) polymers consist of a series of nanocontainers.

  17. EDITORIAL: Where next with global environmental scenarios? Where next with global environmental scenarios?

    NASA Astrophysics Data System (ADS)

    O'Neill, Brian; Pulver, Simone; Van Deveer, Stacy; Garb, Yaakov

    2008-12-01

    Scenarios have become a standard tool in the portfolio of techniques that scientists and policy-makers use to envision and plan for the future. Defined as plausible, challenging and relevant stories about how the future might unfold that integrate quantitative models with qualitative assessments of social and political trends, scenarios are a central component in assessment processes for a range of global issues, including climate change, biodiversity, agriculture, and energy. Yet, despite their prevalence, systematic analysis of scenarios is in its beginning stages. Fundamental questions remain about both the epistemology and scientific credibility of scenarios and their roles in policymaking and social change. Answers to these questions have the potential to determine the future of scenario analyses. Is scenario analysis moving in the direction of earth system governance informed by global scenarios generated through increasingly complex and comprehensive models integrating socio-economic and earth systems? Or will global environmental scenario analyses lose favour compared to more focused, policy-driven, regionally specific modelling? These questions come at an important time for the climate change issue, given that the scenario community, catalyzed by the Intergovernmental Panel on Climate Change (IPCC), is currently preparing to embark on a new round of scenario development processes aimed at coordinating research and assessment, and informing policy, over the next five to ten years. These and related questions about where next to go with global environmental scenarios animated a workshop held at Brown University (Note1) that brought together leading practitioners and scholars of global environmental change scenarios from research, policy-making, advocacy, and business settings. The workshop aimed to provide an overview of current practices/best practices in scenario production and scenario use across a range of global environmental change arenas. Participants

  18. Benign Schwannoma Mimicking Metastatic Lesion on F-18 FDG PET/CT in Differentiated Thyroid Cancer.

    PubMed

    Kang, Sungmin

    2013-06-01

    We report a case of benign schwannoma mimicking metastatic carcinoma. A 55-year-old female with papillary thyroid carcinoma underwent total thyroidectomy. F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) demonstrated a focal hypermetabolic lesion with maximum standardized uptake value (SUVmax) 5.3 at the right chest wall. Conventional chest CT demonstrated a 5.4 cm ovoid mass lesion between the intercostal muscles and liver. Pathology revealed a schwannoma by tumor excision. This case demonstrates that benign schwannoma may demonstrate FDG uptake mimicking metastatic carcinoma.

  19. USGS Multi-Hazards Winter Storm Scenario

    NASA Astrophysics Data System (ADS)

    Cox, D. A.; Jones, L. M.; Perry, S. C.

    2008-12-01

    The USGS began an inter-disciplinary effort, the Multi Hazards Demonstration Project (MHDP), in 2007 to demonstrate how hazards science can improve a community's resiliency to natural disasters including earthquakes, tsunamis, wildfires, landslides, floods and coastal erosion. The project engages the user community in setting research goals and directs efforts towards research products that can be applied to loss reduction and improved resiliency. The first public product of the MHDP was the ShakeOut Earthquake Scenario published in May 2008. It detailed the realistic outcomes of a hypothetical, but plausible, magnitude 7.8 earthquake on the San Andreas Fault in southern California. Over 300 scientist and experts contributed to designing the earthquake and understanding the impacts of such a disaster, including the geotechnical, engineering, social, cultural, environmental, and economic consequences. The scenario advanced scientific understanding and exposed numerous vulnerabilities related to emergency response and lifeline continuity management. The ShakeOut Scenario was the centerpiece of the Nation's largest-ever emergency response exercise in November 2008, dubbed "The Great Southern California ShakeOut" (www.shakeout.org). USGS Multi-Hazards is now preparing for its next major public project, a Winter Storm Scenario. Like the earthquake scenario, experts will be brought together to examine in detail the possibility, cost and consequences of a winter storm disaster including floods, landslides, coastal erosion and inundation; debris flows; biologic consequences like extirpation of endangered species; physical damages like bridge scour, road closures, dam failure, property loss, and water system collapse. Consideration will be given to the vulnerabilities associated with a catastrophic disruption to the water supply to southern California; the resulting impacts on ground water pumping, seawater intrusion, water supply degradation, and land subsidence; and a

  20. Water use implications of biofuel scenarios

    NASA Astrophysics Data System (ADS)

    Teter, J.; Mishra, G. S.; Yeh, S.

    2012-12-01

    Existing studies rely upon attributional lifecycle analysis (LCA) approaches to estimate water intensity of biofuels in liters of irrigated/evapotranspiration water consumed for biofuel production. Such approaches can be misleading. From a policy perspective, a better approach is to compare differential water impacts among scenarios on a landscape scale. We address the shortcomings of existing studies by using consequential LCA, and incorporate direct and indirect land use (changes) of biofuel scenarios, marginal vs. average biofuel water use estimates, future climate, and geographic heterogeneity. We use the outputs of a partial equilibrium economic model, climate and soil data, and a process-based crop-soil-climate-water model to estimate differences in green water (GW - directly from precipitation to soil) and blue water (BW - supplied by irrigation) use among three scenarios: (1) business-as-usual (BAU), (2) Renewable Fuels Standard (RFS) mandates, and (3) a national Low Carbon Fuel Standard (LCFS) plus the RFS scenario. We use spatial statistical methods to interpolate key climatic variables using daily climate observations for the contiguous USA. Finally, we use FAO's crop model AquaCrop to estimate the domestic GW and BW impacts of biofuel policies from 2007-2035. We assess the differences among scenarios along the following metrics: (1) crop area expansion at the county level, including prime and marginal lands, (2) crop-specific and overall annual/seasonal water balances including (a) water inflows (irrigation & precipitation), (b) crop-atmosphere interactions: (evaporation & transpiration) and (d) soil-water flows (runoff & soil infiltration), in mm 3 /acre over the relevant time period. The functional unit of analysis is the BW and GW requirements of biofuels (mm3 per Btu biofuel) at the county level. Differential water use impacts among scenarios are a primarily a function of (1) land use conversion, in particular that of formerly uncropped land classes

  1. Development of nonproliferation and assessment scenarios.

    SciTech Connect

    Finley, Melissa; Barnett, Natalie Beth

    2005-10-01

    The overall objective of the Nonproliferation and Assessments Scenario Development project is to create and analyze potential and plausible scenarios that would lead to an adversary's ability to acquire and use a biological weapon. The initial three months of funding was intended to be used to develop a scenario to demonstrate the efficacy of this analysis methodology; however, it was determined that a substantial amount of preliminary data collection would be needed before a proof of concept scenario could be developed. We have dedicated substantial effort to determine the acquisition pathways for Foot and Mouth Disease Virus, and similar processes will be applied to all pathogens of interest. We have developed a biosecurity assessments database to capture information on adversary skill locales, available skill sets in specific regions, pathogen sources and regulations involved in pathogen acquisition from legitimate facilities. FY06 funding, once released, will be dedicated to data collection on acquisition, production and dissemination requirements on a pathogen basis. Once pathogen data has been collected, scenarios will be developed and scored.

  2. Arctic shipping emissions inventories and future scenarios

    NASA Astrophysics Data System (ADS)

    Corbett, J. J.; Lack, D. A.; Winebrake, J. J.; Harder, S.; Silberman, J. A.; Gold, M.

    2010-10-01

    This paper presents 5 km×5 km Arctic emissions inventories of important greenhouse gases, black carbon and other pollutants under existing and future (2050) scenarios that account for growth of shipping in the region, potential diversion traffic through emerging routes, and possible emissions control measures. These high-resolution, geospatial emissions inventories for shipping can be used to evaluate Arctic climate sensitivity to black carbon (a short-lived climate forcing pollutant especially effective in accelerating the melting of ice and snow), aerosols, and gaseous emissions including carbon dioxide. We quantify ship emissions scenarios which are expected to increase as declining sea ice coverage due to climate change allows for increased shipping activity in the Arctic. A first-order calculation of global warming potential due to 2030 emissions in the high-growth scenario suggests that short-lived forcing of ~4.5 gigagrams of black carbon from Arctic shipping may increase global warming potential due to Arctic ships' CO2 emissions (~42 000 gigagrams) by some 17% to 78%. The paper also presents maximum feasible reduction scenarios for black carbon in particular. These emissions reduction scenarios will enable scientists and policymakers to evaluate the efficacy and benefits of technological controls for black carbon, and other pollutants from ships.

  3. Scenario development in China's electricity sector

    SciTech Connect

    Steenhof, P.A.; Fulton, W.

    2007-07-15

    The continuing growth of China's electricity sector will affect global environmental and economic sustainability due to its impacts on greenhouse gas emissions and global resource depletion. In 2005, the generation of electricity in China resulted in the emissions of 2290 million metric tonnes of carbon dioxide (approximately 53% of the nation's total) and required 779 million metric tonnes of coal (approximately 50% of China's total coal consumption). These figures are expected to increase with China's economic growth. In order to gauge the range in which fuel consumption and CO{sub 2} emissions could grow a scenario-based conceptual model has been developed by the authors (published in this journal). The application and analysis of this shows that under a business as usual (BAU) scenario, electricity generation could contribute upwards of 56% of China's energy related greenhouse gas emissions by 2020. Meanwhile, consumption of coal will also increase, growing to nearly 60% of total national demand by 2020. However, variations in a number of key drivers could produce significant deviation from the BAU scenario. With accelerated economic output, even with greater technological advances and greater potential to bring natural gas on stream, carbon dioxide emissions would rise 10% above the BAU. Alternatively, in a scenario where China's economy grows at a tempered pace, less investment would be available for advanced technologies, developing natural gas infrastructure, or nuclear energy. In this scenario, reduced economic growth and electricity demand would thereby be countered by reduced efficiency and a higher contribution of coal.

  4. 30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.26... the facility that oil could move in a time period that it reasonably could be expected to persist...

  5. 30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.26... the facility that oil could move in a time period that it reasonably could be expected to persist...

  6. 30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf... maximum distance from the facility that oil could move in a time period that it reasonably could...

  7. 30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.26 What information... that oil could move in a time period that it reasonably could be expected to persist in the...

  8. 30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.26... the facility that oil could move in a time period that it reasonably could be expected to persist...

  9. Representation Techniques for Relational Languages and the Worst Case Asymptotical Time Complexity Behaviour of the Related Algorithms.

    DTIC Science & Technology

    1982-06-01

    Requirements ... 37 3. System Hash Tables and TheLr Structure .. 43 a. RelatLon Table ................. .... 43 b. Left Hash Table ..... ... ......... 44 c...RLght Bash Table o..................... 47 d. got Table o............................ 47 -- ± -5 -"-::,:;-.-..:./ :--.-:*:.: -...’ • .-4 e. Set Hash ...Table ........................ 49 f. Scratch Hash Table .................... 51 4. Hash Functions ............................ 51 5. Referencing the

  10. Endocrine-disrupting chemicals and climate change: A worst-case combination for arctic marine mammals and seabirds?

    PubMed

    Jenssen, Bjørn Munro

    2006-04-01

    The effects of global change on biodiversity and ecosystem functioning encompass multiple complex dynamic processes. Climate change and exposure to endocrine-disrupting chemicals (EDCs) are currently regarded as two of the most serious anthropogenic threats to biodiversity and ecosystems. We should, therefore, be especially concerned about the possible effects of EDCs on the ability of Arctic marine mammals and seabirds to adapt to environmental alterations caused by climate change. Relationships between various organochlorine compounds, necessary such as polychlorinated biphenyls, dichlorophenyldichloroethylene, hexachlorobenzene, and oxychlordane, and hormones in Arctic mammals and seabirds imply that these chemicals pose a threat to endocrine systems of these animals. The most pronounced relationships have been reported with the thyroid hormone system, but effects are also seen in sex steroid hormones and cortisol. Even though behavioral and morphological effects of persistent organic pollutants are consistent with endocrine disruption, no direct evidence exists for such relationships. Because different endocrine systems are important for enabling animals to respond adequately to environmental stress, EDCs may interfere with adaptations to increased stress situations. Such interacting effects are likely related to adaptive responses regulated by the thyroid, sex steroid, and glucocorticosteroid systems.

  11. A heuristic approach to worst-case carrier-to-interference ratio maximization in satellite system synthesis

    NASA Technical Reports Server (NTRS)

    Reilly, Charles H.; Walton, Eric K.; Mata, Fernando; Mount-Campbell, Clark A.; Olen, Carl A.

    1990-01-01

    Consideration is given to the problem of allotting GEO locations to communication satellites so as to maximize the smallest aggregate carrier-to-interference (C/I) ratio calculated at any test point (assumed earth station). The location allotted to each satellite must be within the satellite's service arc, and angular separation constraints are enforced for each pair of satellites to control single-entry EMI. Solutions to this satellite system synthesis problem (SSSP) are found by embedding two heuristic procedures for the satellite location problem (SLP), in a binary search routine to find an estimate of the largest increment to the angular separation values that permits a feasible solution to SLP and SSSP. Numerical results for a 183-satellite, 208-beam example problem are presented.

  12. An on-road shock and vibration response test series utilizing worst case and statistical analysis techniques

    SciTech Connect

    Cap, J.S.

    1997-11-01

    Defining the maximum expected shock and vibration responses for an on-road truck transportation environment is strongly dependent on the amount of response data that can be obtained. One common test scheme consists of measuring response data over a relatively short prescribed road course and then reviewing that data to obtain the maximum response levels. The more mathematically rigorous alternative is to collect an unbiased ensemble of response data during a long road trip. This paper compares data gathered both ways during a recent on-road certification test for a tractor trailer van being designed by Sandia.

  13. Nucleus-staining with biomolecule-mimicking nitrogen-doped carbon dots prepared by a fast neutralization heat strategy.

    PubMed

    Kang, Yan-Fei; Fang, Yang-Wu; Li, Yu-Hao; Li, Wen; Yin, Xue-Bo

    2015-12-11

    Biomolecule-mimicking nitrogen-doped carbon dots (N-Cdots) were synthesized from dopamine by a neutralization heat strategy. Fluorescence imaging of various cells validated their nucleus-staining efficiency. The dopamine-mimicking N-Cdots "trick" nuclear membranes to achieve nuclear localization and imaging.

  14. Generating Scenarios When Data Are Missing

    NASA Technical Reports Server (NTRS)

    Mackey, Ryan

    2007-01-01

    The Hypothetical Scenario Generator (HSG) is being developed in conjunction with other components of artificial-intelligence systems for automated diagnosis and prognosis of faults in spacecraft, aircraft, and other complex engineering systems. The HSG accepts, as input, possibly incomplete data on the current state of a system (see figure). The HSG models a potential fault scenario as an ordered disjunctive tree of conjunctive consequences, wherein the ordering is based upon the likelihood that a particular conjunctive path will be taken for the given set of inputs. The computation of likelihood is based partly on a numerical ranking of the degree of completeness of data with respect to satisfaction of the antecedent conditions of prognostic rules. The results from the HSG are then used by a model-based artificial- intelligence subsystem to predict realistic scenarios and states.

  15. Creating a Scenario Suitable for Multiple Caregivers

    NASA Technical Reports Server (NTRS)

    Doerr, Harold; Bacal, Kira; Hurst, Victor

    2004-01-01

    The HPS can be utilized for the training of a wide variety of caregivers, ranging from physicians to laypeople. Methods: A single scenario was developed and adapted for a number of clinical scenarios and operational environments, ranging from in-flight to the immediate postflight timeline. In this way, different caregivers, from astronauts to search and rescue forces to specialty-boarded physicians, could make use of a single clinical situation. Five crew medical officer analogs and sixty anesthesia residents, serving as flight surgeon analogs, and, were briefed on space medicine and physiology, then were exposed to the scenario and asked to manage the patient as if they were part of the in-flight or recovery team. Results: Basic themes, such as crisis resource management, were standard across the student audiences. Discussion: A single clinical script can easily be adapted for multiple uses.

  16. Scenarios for the making of vertebrates.

    PubMed

    Holland, Nicholas D; Holland, Linda Z; Holland, Peter W H

    2015-04-23

    Over the past 200 years, almost every invertebrate phylum has been proposed as a starting point for evolving vertebrates. Most of these scenarios are outdated, but several are still seriously considered. The short-range transition from ancestral invertebrate chordates (similar to amphioxus and tunicates) to vertebrates is well accepted. However, longer-range transitions leading up to the invertebrate chordates themselves are more controversial. Opinion is divided between the annelid and the enteropneust scenarios, predicting, respectively, a complex or a simple ancestor for bilaterian animals. Deciding between these ideas will be facilitated by further comparative studies of multicellular animals, including enigmatic taxa such as xenacoelomorphs.

  17. Mimicking Nonequilibrium Steady States with Time-Periodic Driving

    NASA Astrophysics Data System (ADS)

    Raz, Oren; Subasi, Yigit; Jarzynski, Christopher

    Under static conditions, a system satisfying detailed balance generically relaxes to an equilibrium state in which there are no currents: to generate persistent currents, either detailed balance must be broken or the system must be driven in a time-dependent manner. A stationary system that violates detailed balance evolves to a nonequilibrium steady state (NESS) characterized by fixed currents. Conversely, a system that satisfies instantaneous detailed balance but is driven by the time-periodic variation of external parameters - also known as a stochastic pump (SP) - reaches a periodic state with non-vanishing currents. In both cases, these currents are maintained at the cost of entropy production. Are these two paradigmatic scenarios effectively equivalent? For discrete-state systems we establish a mapping between NESS and SP. Given a NESS characterized by a particular set of stationary probabilities, currents and entropy production rates, we show how to construct a SP with exactly the same (time-averaged) values. The mapping works in the opposite direction as well. These results establish a proof of principle: they show that SP are able to mimic the behavior of NESS, and vice-versa, within the theoretical framework of discrete-state stochastic thermodynamics.

  18. Most Probable Fire Scenarios in Spacecraft and Extraterrestrial Habitats: Why NASA's Current Test 1 Might Not Always be Conservative

    NASA Technical Reports Server (NTRS)

    Olson, S. L.

    2004-01-01

    NASA's current method of material screening determines fire resistance under conditions representing a worst-case for normal gravity flammability - the Upward Flame Propagation Test (Test 1). Its simple pass-fail criteria eliminates materials that burn for more than 12 inches from a standardized ignition source. In addition, if a material drips burning pieces that ignite a flammable fabric below, it fails. The applicability of Test 1 to fires in microgravity and extraterrestrial environments, however, is uncertain because the relationship between this buoyancy-dominated test and actual extraterrestrial fire hazards is not understood. There is compelling evidence that the Test 1 may not be the worst case for spacecraft fires, and we don t have enough information to assess if it is adequate at Lunar or Martian gravity levels.

  19. Most Probable Fire Scenarios in Spacecraft and Extraterrestrial Habitats: Why NASA's Current Test 1 Might Not Always Be Conservative

    NASA Technical Reports Server (NTRS)

    Olson, S. L.

    2004-01-01

    NASA s current method of material screening determines fire resistance under conditions representing a worst-case for normal gravity flammability - the Upward Flame Propagation Test (Test 1[1]). Its simple pass-fail criteria eliminates materials that burn for more than 12 inches from a standardized ignition source. In addition, if a material drips burning pieces that ignite a flammable fabric below, it fails. The applicability of Test 1 to fires in microgravity and extraterrestrial environments, however, is uncertain because the relationship between this buoyancy-dominated test and actual extraterrestrial fire hazards is not understood. There is compelling evidence that the Test 1 may not be the worst case for spacecraft fires, and we don t have enough information to assess if it is adequate at Lunar or Martian gravity levels.

  20. Optimizing Decision Preparedness by Adapting Scenario Complexity and Automating Scenario Generation

    NASA Technical Reports Server (NTRS)

    Dunne, Rob; Schatz, Sae; Flore, Stephen M.; Nicholson, Denise

    2011-01-01

    Klein's recognition-primed decision (RPD) framework proposes that experts make decisions by recognizing similarities between current decision situations and previous decision experiences. Unfortunately, military personnel arQ often presented with situations that they have not experienced before. Scenario-based training (S8T) can help mitigate this gap. However, SBT remains a challenging and inefficient training approach. To address these limitations, the authors present an innovative formulation of scenario complexity that contributes to the larger research goal of developing an automated scenario generation system. This system will enable trainees to effectively advance through a variety of increasingly complex decision situations and experiences. By adapting scenario complexities and automating generation, trainees will be provided with a greater variety of appropriately calibrated training events, thus broadening their repositories of experience. Preliminary results from empirical testing (N=24) of the proof-of-concept formula are presented, and future avenues of scenario complexity research are also discussed.

  1. Pulmonary cavitation and skin lesions mimicking tuberculosis in a HIV negative patient caused by Sporothrix brasiliensis

    PubMed Central

    Orofino-Costa, Rosane; Unterstell, Natasha; Carlos Gripp, Alexandre; de Macedo, Priscila Marques; Brota, Arles; Dias, Emylli; de Melo Teixeira, Marcus; Felipe, Maria Sueli; Bernardes-Engemann, Andréa R; Lopes-Bezerra, Leila Maria

    2013-01-01

    A 32-year-old HIV negative male presented with multiple pulmonary cavitation and skin abscesses up to 15 cm in diameter mimicking tuberculosis. Sporothrix brasiliensis was isolated and patient responded well to amphotericin B followed by itraconazole, except the skin lesions that had to be surgical drained to obtain cure. PMID:24432220

  2. Marked left ventricular hypertrophy mimicking hypertrophic cardiomyopathy associated with steroid therapy for congenital adrenal hyperplasia.

    PubMed

    Scirè, Giuseppe; D'Anella, Giorgio; Cristofori, Laura; Mazzuca, Valentina; Cianfarani, Stefano

    2007-06-01

    We describe a child treated with high-dose steroid therapy for congenital adrenal hyperplasia who showed marked left ventricular hypertrophy mimicking hypertrophic cardiomyopathy associated with steroid therapy for congenital adrenal hyperplasia. Cardiomyopathy reversed completely when an appropriate steroid therapeutic regimen was established.

  3. Being Mimicked Increases Prosocial Behavior in 18-Month-Old Infants

    ERIC Educational Resources Information Center

    Carpenter, Malinda; Uebel, Johanna; Tomasello, Michael

    2013-01-01

    Most previous research on imitation in infancy has focused on infants' learning of instrumental actions on objects. This study focused instead on the more social side of imitation, testing whether being mimicked increases prosocial behavior in infants, as it does in adults (van Baaren, Holland, Kawakami, & van Knippenberg, 2004).…

  4. Collar Osteophytes Mimicking Osteonecrosis in Planar Bone Scintigraphy and Usefulness of SPECT/CT Images.

    PubMed

    Juang, Jr-Jian; Chen, Yi-Hsing; Tsai, Shih-Chuan; Lin, Wan-Yu

    2017-03-01

    The use of prednisolone is one major risk factor for osteonecrosis in patients with systemic lupus erythematosus. Bone scintigraphy can be a diagnostic tool for early diagnosis. We present a case who had collar osteophytes at the bilateral femoral heads, which mimicked osteonecrosis in the planar bone scintigram. An SPECT/CT scan avoided this pitfall and increased the diagnostic accuracy for osteonecrosis.

  5. Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings.

    PubMed

    Park, Ji Ung; Ham, Jiyeon; Kim, Sukwha; Seo, Ji-Hun; Kim, Sang-Hyon; Lee, Seonju; Min, Hye Jeong; Choi, Sunghyun; Choi, Ra Mi; Kim, Heejin; Oh, Sohee; Hur, Ji An; Choi, Tae Hyun; Lee, Yan

    2014-10-01

    Despite their popular use in breast augmentation and reconstruction surgeries, the limited biocompatibility of silicone implants can induce severe side effects, including capsular contracture - an excessive foreign body reaction that forms a tight and hard fibrous capsule around the implant. This study examines the effects of using biomembrane-mimicking surface coatings to prevent capsular formations on silicone implants. The covalently attached biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on the silicone surface. More importantly, in vivo capsule formations around PMPC-grafted silicone implants in rats were significantly thinner and exhibited lower collagen densities and more regular collagen alignments than bare silicone implants. The observed decrease in α-smooth muscle actin also supported the alleviation of capsular formations by the biomembrane-mimicking coating. Decreases in inflammation-related cells, myeloperoxidase and transforming growth factor-β resulted in reduced inflammation in the capsular tissue. The biomembrane-mimicking coatings used on these silicone implants demonstrate great potential for preventing capsular contracture and developing biocompatible materials for various biomedical applications.

  6. Synonymies of wasp-mimicking species within the katydid genus Aganacris (Orthoptera: Tettigoniidae: Phaneropterinae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Five neotropical wasp-mimicking species of the genus Aganacris—two known from females only and three from males only—are reviewed. Based on observations of interspecific interactions and morphological comparisons, sexual dimorphism is shown to occur within species, and that female species are consp...

  7. Redox enzyme-mimicking activities of CeO2 nanostructures: Intrinsic influence of exposed facets.

    PubMed

    Yang, Yushi; Mao, Zhou; Huang, Wenjie; Liu, Lihua; Li, Junli; Li, Jialiang; Wu, Qingzhi

    2016-10-17

    CeO2 nanoparticles (NPs) have been well demonstrated as an antioxidant in protecting against oxidative stress-induced cellular damages and a potential therapeutic agent for various diseases thanks to their redox enzyme-mimicking activities. The Ce(3+)/Ce(4+) ratio and oxygen vacancies on the surface have been considered as the major originations responsible for the redox enzyme-mimicking activities of CeO2 NPs. Herein, CeO2 nanostructures (nanocubes and nanorods) exposed different facets were synthesized via a facile hydrothermal method. The characterizations by X-ray photoelectron spectroscopy, Raman spectroscopy, and UV-Vis spectroscopy show that the Ce(3+)/Ce(4+) ratio and oxygen vacancy content on the surfaces of as-synthesized CeO2 nanostructures are nearly at the same levels. Meanwhile, the enzymatic activity measurements indicate that the redox enzyme-mimicking activities of as-synthesized CeO2 nanostructures are greatly dependent on their exposed facets. CeO2 nanocubes with exposed {100} facets exhibit a higher peroxidase but lower superoxide dismutase activity than those of the CeO2 nanorods with exposed {110} facets. Our results provide new insights into the redox enzyme-mimicking activities of CeO2 nanostructures, as well as the design and synthesis of inorganic nanomaterials-based artificial enzymes.

  8. Mimicking time evolution within a quantum ground state: Ground-state quantum computation, cloning, and teleportation

    SciTech Connect

    Mizel, Ari

    2004-07-01

    Ground-state quantum computers mimic quantum-mechanical time evolution within the amplitudes of a time-independent quantum state. We explore the principles that constrain this mimicking. A no-cloning argument is found to impose strong restrictions. It is shown, however, that there is flexibility that can be exploited using quantum teleportation methods to improve ground-state quantum computer design.

  9. Redox enzyme-mimicking activities of CeO2 nanostructures: Intrinsic influence of exposed facets

    NASA Astrophysics Data System (ADS)

    Yang, Yushi; Mao, Zhou; Huang, Wenjie; Liu, Lihua; Li, Junli; Li, Jialiang; Wu, Qingzhi

    2016-10-01

    CeO2 nanoparticles (NPs) have been well demonstrated as an antioxidant in protecting against oxidative stress-induced cellular damages and a potential therapeutic agent for various diseases thanks to their redox enzyme-mimicking activities. The Ce3+/Ce4+ ratio and oxygen vacancies on the surface have been considered as the major originations responsible for the redox enzyme-mimicking activities of CeO2 NPs. Herein, CeO2 nanostructures (nanocubes and nanorods) exposed different facets were synthesized via a facile hydrothermal method. The characterizations by X-ray photoelectron spectroscopy, Raman spectroscopy, and UV-Vis spectroscopy show that the Ce3+/Ce4+ ratio and oxygen vacancy content on the surfaces of as-synthesized CeO2 nanostructures are nearly at the same levels. Meanwhile, the enzymatic activity measurements indicate that the redox enzyme-mimicking activities of as-synthesized CeO2 nanostructures are greatly dependent on their exposed facets. CeO2 nanocubes with exposed {100} facets exhibit a higher peroxidase but lower superoxide dismutase activity than those of the CeO2 nanorods with exposed {110} facets. Our results provide new insights into the redox enzyme-mimicking activities of CeO2 nanostructures, as well as the design and synthesis of inorganic nanomaterials-based artificial enzymes.

  10. Redox enzyme-mimicking activities of CeO2 nanostructures: Intrinsic influence of exposed facets

    PubMed Central

    Yang, Yushi; Mao, Zhou; Huang, Wenjie; Liu, Lihua; Li, Junli; Li, Jialiang; Wu, Qingzhi

    2016-01-01

    CeO2 nanoparticles (NPs) have been well demonstrated as an antioxidant in protecting against oxidative stress-induced cellular damages and a potential therapeutic agent for various diseases thanks to their redox enzyme-mimicking activities. The Ce3+/Ce4+ ratio and oxygen vacancies on the surface have been considered as the major originations responsible for the redox enzyme-mimicking activities of CeO2 NPs. Herein, CeO2 nanostructures (nanocubes and nanorods) exposed different facets were synthesized via a facile hydrothermal method. The characterizations by X-ray photoelectron spectroscopy, Raman spectroscopy, and UV-Vis spectroscopy show that the Ce3+/Ce4+ ratio and oxygen vacancy content on the surfaces of as-synthesized CeO2 nanostructures are nearly at the same levels. Meanwhile, the enzymatic activity measurements indicate that the redox enzyme-mimicking activities of as-synthesized CeO2 nanostructures are greatly dependent on their exposed facets. CeO2 nanocubes with exposed {100} facets exhibit a higher peroxidase but lower superoxide dismutase activity than those of the CeO2 nanorods with exposed {110} facets. Our results provide new insights into the redox enzyme-mimicking activities of CeO2 nanostructures, as well as the design and synthesis of inorganic nanomaterials-based artificial enzymes. PMID:27748403

  11. Linguistic evaluation of terrorist scenarios: example application.

    SciTech Connect

    Darby, John L.

    2007-03-01

    In 2005, a group of international decision makers developed a manual process for evaluating terrorist scenarios. That process has been implemented in the approximate reasoning Java software tool, LinguisticBelief, released in FY2007. One purpose of this report is to show the flexibility of the LinguisticBelief tool to automate a custom model developed by others. LinguisticBelief evaluates combinations of linguistic variables using an approximate reasoning rule base. Each variable is comprised of fuzzy sets, and a rule base describes the reasoning on combinations of variables fuzzy sets. Uncertainty is considered and propagated through the rule base using the belief/plausibility measure. This report documents the evaluation and rank-ordering of several example terrorist scenarios for the existing process implemented in our software. LinguisticBelief captures and propagates uncertainty and allows easy development of an expanded, more detailed evaluation, neither of which is feasible using a manual evaluation process. In conclusion, the Linguistic-Belief tool is able to (1) automate an expert-generated reasoning process for the evaluation of the risk of terrorist scenarios, including uncertainty, and (2) quickly evaluate and rank-order scenarios of concern using that process.

  12. Chemical Data Reporting Byproduct and Recycling Scenarios

    EPA Pesticide Factsheets

    This document addresses a series of 18 industry scenarios and questions related to EPA’s Chemical Data Reporting (CDR) rule. The primary goal of this document is to help the regulated community comply with the requirements of the CDR rule.

  13. Biomass round bales infield aggregation logistic scenarios

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Biomass bales often need to be aggregated (collected into groups and transported) to a field-edge stack for temporary storage for feedlots or processing facilities. Aggregating the bales with the least total distance involved is a goal of producers and bale handlers. Several logistics scenarios for ...

  14. Ethics Scenarios: A Critical Theory Symposium.

    ERIC Educational Resources Information Center

    Anderson, Jane; And Others

    This symposium chaired by John C. Belland addressed the ethical position of educational communications and technology in society. Presenters created ethics scenarios and applied critical theory to provide insight. Intended to stimulate questions, the approach was philosophical, literary, and sociopolitical, and reflected Derrida, Foucault, and…

  15. Flooding Capability for River-based Scenarios

    SciTech Connect

    Smith, Curtis L.; Prescott, Steven; Ryan, Emerald; Calhoun, Donna; Sampath, Ramprasad; Anderson, S. Danielle; Casteneda, Cody

    2015-10-01

    This report describes the initial investigation into modeling and simulation tools for application of riverine flooding representation as part of the Risk-Informed Safety Margin Characterization (RISMC) Pathway external hazards evaluations. The report provides examples of different flooding conditions and scenarios that could impact river and watershed systems. Both 2D and 3D modeling approaches are described.

  16. Scenario Development for Information Operations (IO) Experimentation

    DTIC Science & Technology

    2003-07-10

    valid OMB control number. 1. REPORT DATE 01 OCT 2003 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Scenario Development for...country called DYSLEXIA , whose government has been making threats to invade and appropriate a region of its neighbouring country, ABSTEMIA, which is

  17. Iterative Mechanism Solutions with Scenario and ADAMS

    NASA Technical Reports Server (NTRS)

    Rhoades, Daren

    2006-01-01

    This slide presentation reviews the use of iterative solutions using Scenario for Motion (UG NX 2 Motion) to assist in designing the Mars Science Laboratory (MSL). The MSL will have very unique design requirements, and in order to meet these requirements the system must have the ability to design for static stability, simulate mechanism kinematics, simulate dynamic behaviour and be capable of reconfiguration, and iterations as designed. The legacy process used on the Mars Exploration rovers worked, but it was cumbersome using multiple tools, limited configuration control, with manual process and communication, and multiple steps. The aim is to develop a mechanism that would reduce turn around time, and make more reiterations possible, to improve the quality and quantity of data, and to enhance configuration control. Currently for NX Scenario for Motion uses are in the articulation studies, the simulations of traverse motions,and subsystem simulations. The design of the Rover landing model requires accurate results, flexible elements, such as beams, and the use of the full ADAMS solver has been used. In order to achieve this, when required, there has been a direct translation from Scenario to ADAMS, with additional data in ascii format. The process that has been designed to move from Scenario to ADAMS is reviewed.

  18. National FCEV and Hydrogen Fueling Station Scenarios

    SciTech Connect

    Bush, Brian; Melaina, Marc

    2016-06-09

    This presentation provides a summary of the FY16 activities and accomplishments for NREL's national fuel cell electric vehicle (FCEV) and hydrogen fueling station scenarios project. It was presented at the U.S. Department of Energy Hydrogen and Fuel Cells Program 2016 Annual Merit Review and Peer Evaluation Meeting on June 9, 2016, in Washington, D.C.

  19. Probabilistic Simulation of Territorial Seismic Scenarios

    SciTech Connect

    Baratta, Alessandro; Corbi, Ileana

    2008-07-08

    The paper is focused on a stochastic process for the prevision of seismic scenarios on the territory and developed by means of some basic assumptions in the procedure and by elaborating the fundamental parameters recorded during some ground motions occurred in a seismic area.

  20. Probabilistic Simulation of Territorial Seismic Scenarios

    NASA Astrophysics Data System (ADS)

    Baratta, Alessandro; Corbi, Ileana

    2008-07-01

    The paper is focused on a stochastic process for the prevision of seismic scenarios on the territory and developed by means of some basic assumptions in the procedure and by elaborating the fundamental parameters recorded during some ground motions occurred in a seismic area.

  1. Risk Appraisal in Scripted Acquaintance Rape Scenarios.

    ERIC Educational Resources Information Center

    Wright, Doris J.

    Cognitive appraisals are believed to influence how women judge or appraise risk in acquaintance interactions which lead to sexual assault. Ways in which men and women judge the presence of risk factors in scripted acquaintance rape scenarios, and whether alcohol was a significant factor in assessing risk, are examined in this paper. Participants…

  2. Wiki Based Collaborative Learning in Interuniversity Scenarios

    ERIC Educational Resources Information Center

    Katzlinger, Elisabeth; Herzog, Michael A.

    2014-01-01

    In business education advanced collaboration skills and media literacy are important for surviving in a globalized business where virtual communication between enterprises is part of the day-by-day business. To transform these global working situations into higher education, a learning scenario between two universities in Germany and Austria was…

  3. Interactive, multiobjective Bayesian optimization of tokamak scenarios

    NASA Astrophysics Data System (ADS)

    Urban, Jakub; Artaud, Jean-François

    2016-10-01

    Bayesian optimization is applied to tokamak scenario optimizations. The key advantages are 1) a reduced number of objective function evaluations, 2) no need for derivatives, and 3) the possibility to include a prior knowledge. This is of a great value for optimizing tokamak scenarios, where several (competing) objectives with often unknown magnitudes exist and the number of parameters is large (>10). The first two properties imply that Bayesian optimization is well suited for heavy, complex objective functions. Reusing previous iterations as priors for next optimization steps effectively enables interactive, multiobjective optimizations, regardless of whether a human decision maker is included or not. We show that these features make Bayesian optimization an outstanding tool for optimizing tokamak scenarios. Objective functions and constraints, targeting, e.g., fusion gain, flux consumption, coils currents limits or q-profile, can be assembled interactively. The optimized parameter vector may include actuators like plasma current or heating waveforms. We demonstrate the capabilities on optimizing ITER and DEMO-like scenarios, simulated by the METIS code.

  4. Using Scenarios and Simulations to Plan Colleges

    ERIC Educational Resources Information Center

    McIntyre, Chuck

    2004-01-01

    Using a case study, this article describes a method by which higher education institutions construct and use multiple future scenarios and simulations to plan strategically: to create visions of their futures, chart broad directions (mission and goals), and select learning and delivery strategies so as to achieve those broad directions. The…

  5. Future Scenarios for Mobile Science Learning

    ERIC Educational Resources Information Center

    Burden, Kevin; Kearney, Matthew

    2016-01-01

    This paper adopts scenario planning as a methodological approach and tool to help science educators reconceptualise their use of mobile technologies across various different futures. These "futures" are set out neither as predictions nor prognoses but rather as stimuli to encourage greater discussion and reflection around the use of…

  6. Use of simplifier scenarios for CRM training

    NASA Technical Reports Server (NTRS)

    Weatherly, D.

    1984-01-01

    Cockpit resource management (CRM) at Metro Airlines is discussed. The process by which the program of CRM training was initiated is mentioned. Management aspects of various flying scenarios are considered. The transfer of training from the classroom to the field is assessed.

  7. Scenarios Based on Shared Socioeconomic Pathway Assumptions

    NASA Astrophysics Data System (ADS)

    Edmonds, J.

    2013-12-01

    A set of new scenarios is being developed by the international scientific community as part of a larger program that was articulated in Moss, et al. (2009), published in Nature. A long series of meetings including climate researchers drawn from the climate modeling, impacts, adaptation and vulnerability (IAV) and integrated assessment modeling (IAM) communities have led to the development of a set of five Shared Socioeconomic Pathways (SSPs), which define the state of human and natural societies at a macro scale over the course of the 21st century without regard to climate mitigation or change. SSPs were designed to explore a range of possible futures consistent with greater or lesser challenges to mitigation and challenges to adaptation. They include a narrative storyline and a set of quantified measures--e.g. demographic and economic profiles--that define the high-level state of society as it evolves over the 21st century under the assumption of no significant climate feedback. SSPs can be used to develop quantitative scenarios of human Earth systems using IAMs. IAMs produce information about greenhouse gas emissions, energy systems, the economy, agriculture and land use. Each set of SSPs will have a different human Earth system realization for each IAM. Five groups from the IAM community have begun to explore the implications of SSP assumptions for emissions, energy, economy, agriculture and land use. We report the quantitative results of initial experiments from those groups. A major goal of the Moss, et al. strategy was to enable the use of CMIP5 climate model ensemble products for IAV research. CMIP5 climate scenarios used four Representative Concentration Pathway (RCP) scenarios, defined in terms of radiative forcing in the year 2100: 2.6, 4.5, 6.0, and 8.5 Wm-2. There is no reason to believe that the SSPs will generate year 2100 levels of radiative forcing that correspond to the four RCP levels, though it is important that at least one SSP produce a

  8. Generating moment matching scenarios using optimization techniques

    SciTech Connect

    Mehrotra, Sanjay; Papp, Dávid

    2013-05-16

    An optimization based method is proposed to generate moment matching scenarios for numerical integration and its use in stochastic programming. The main advantage of the method is its flexibility: it can generate scenarios matching any prescribed set of moments of the underlying distribution rather than matching all moments up to a certain order, and the distribution can be defined over an arbitrary set. This allows for a reduction in the number of scenarios and allows the scenarios to be better tailored to the problem at hand. The method is based on a semi-infinite linear programming formulation of the problem that is shown to be solvable with polynomial iteration complexity. A practical column generation method is implemented. The column generation subproblems are polynomial optimization problems; however, they need not be solved to optimality. It is found that the columns in the column generation approach can be efficiently generated by random sampling. The number of scenarios generated matches a lower bound of Tchakaloff's. The rate of convergence of the approximation error is established for continuous integrands, and an improved bound is given for smooth integrands. Extensive numerical experiments are presented in which variants of the proposed method are compared to Monte Carlo and quasi-Monte Carlo methods on both numerical integration problems and stochastic optimization problems. The benefits of being able to match any prescribed set of moments, rather than all moments up to a certain order, is also demonstrated using optimization problems with 100-dimensional random vectors. Here, empirical results show that the proposed approach outperforms Monte Carlo and quasi-Monte Carlo based approaches on the tested problems.

  9. Generating moment matching scenarios using optimization techniques

    DOE PAGES

    Mehrotra, Sanjay; Papp, Dávid

    2013-05-16

    An optimization based method is proposed to generate moment matching scenarios for numerical integration and its use in stochastic programming. The main advantage of the method is its flexibility: it can generate scenarios matching any prescribed set of moments of the underlying distribution rather than matching all moments up to a certain order, and the distribution can be defined over an arbitrary set. This allows for a reduction in the number of scenarios and allows the scenarios to be better tailored to the problem at hand. The method is based on a semi-infinite linear programming formulation of the problem thatmore » is shown to be solvable with polynomial iteration complexity. A practical column generation method is implemented. The column generation subproblems are polynomial optimization problems; however, they need not be solved to optimality. It is found that the columns in the column generation approach can be efficiently generated by random sampling. The number of scenarios generated matches a lower bound of Tchakaloff's. The rate of convergence of the approximation error is established for continuous integrands, and an improved bound is given for smooth integrands. Extensive numerical experiments are presented in which variants of the proposed method are compared to Monte Carlo and quasi-Monte Carlo methods on both numerical integration problems and stochastic optimization problems. The benefits of being able to match any prescribed set of moments, rather than all moments up to a certain order, is also demonstrated using optimization problems with 100-dimensional random vectors. Here, empirical results show that the proposed approach outperforms Monte Carlo and quasi-Monte Carlo based approaches on the tested problems.« less

  10. The future of scenarios: issues in developing new climate change scenarios

    NASA Astrophysics Data System (ADS)

    Pitcher, Hugh M.

    2009-04-01

    In September, 2007, the IPCC convened a workshop to discuss how a new set of scenarios to support climate model runs, mitigation analyses, and impact, adaptation and vulnerability research might be developed. The first phase of the suggested new approach is now approaching completion. This article discusses some of the issues raised by scenario relevant research and analysis since the last set of IPCC scenarios were created (IPCC SRES, 2000) that will need to be addressed as new scenarios are developed by the research community during the second phase. These include (1) providing a logic for how societies manage to transition from historical paths to the various future development paths foreseen in the scenarios, (2) long-term economic growth issues, (3) the appropriate GDP metric to use (purchasing power parity or market exchange rates), (4) ongoing issues with moving from the broad geographic and time scales of the emission scenarios to the finer scales needed for impacts, adaptation and vulnerability analyses and (5) some possible ways to handle the urgent request from the policy community for some guidance on scenario likelihoods. The challenges involved in addressing these issues are manifold; the reward is greater credibility and deeper understanding of an analytic tool that does much to form the context within which many issues in addition to the climate problem will need to be addressed.

  11. The Scenario Model Intercomparison Project (ScenarioMIP) for CMIP6

    NASA Astrophysics Data System (ADS)

    O'Neill, Brian C.; Tebaldi, Claudia; van Vuuren, Detlef P.; Eyring, Veronika; Friedlingstein, Pierre; Hurtt, George; Knutti, Reto; Kriegler, Elmar; Lamarque, Jean-Francois; Lowe, Jason; Meehl, Gerald A.; Moss, Richard; Riahi, Keywan; Sanderson, Benjamin M.

    2016-09-01

    Projections of future climate change play a fundamental role in improving understanding of the climate system as well as characterizing societal risks and response options. The Scenario Model Intercomparison Project (ScenarioMIP) is the primary activity within Phase 6 of the Coupled Model Intercomparison Project (CMIP6) that will provide multi-model climate projections based on alternative scenarios of future emissions and land use changes produced with integrated assessment models. In this paper, we describe ScenarioMIP's objectives, experimental design, and its relation to other activities within CMIP6. The ScenarioMIP design is one component of a larger scenario process that aims to facilitate a wide range of integrated studies across the climate science, integrated assessment modeling, and impacts, adaptation, and vulnerability communities, and will form an important part of the evidence base in the forthcoming Intergovernmental Panel on Climate Change (IPCC) assessments. At the same time, it will provide the basis for investigating a number of targeted science and policy questions that are especially relevant to scenario-based analysis, including the role of specific forcings such as land use and aerosols, the effect of a peak and decline in forcing, the consequences of scenarios that limit warming to below 2 °C, the relative contributions to uncertainty from scenarios, climate models, and internal variability, and long-term climate system outcomes beyond the 21st century. To serve this wide range of scientific communities and address these questions, a design has been identified consisting of eight alternative 21st century scenarios plus one large initial condition ensemble and a set of long-term extensions, divided into two tiers defined by relative priority. Some of these scenarios will also provide a basis for variants planned to be run in other CMIP6-Endorsed MIPs to investigate questions related to specific forcings. Harmonized, spatially explicit

  12. The Scenario Model Intercomparison Project (ScenarioMIP) for CMIP6

    SciTech Connect

    O'Neill, Brian C.; Tebaldi, Claudia; van Vuuren, Detlef P.; Eyring, Veronika; Friedlingstein, Pierre; Hurtt, George; Knutti, Reto; Kriegler, Elmar; Lamarque, Jean-Francois; Lowe, Jason; Meehl, Gerald A.; Moss, Richard; Riahi, Keywan; Sanderson, Benjamin M.

    2016-01-01

    Projections of future climate change play a fundamental role in improving understanding of the climate system as well as characterizing societal risks and response options. The Scenario Model Intercomparison Project (ScenarioMIP) is the primary activity within Phase 6 of the Coupled Model Intercomparison Project (CMIP6) that will provide multi-model climate projections based on alternative scenarios of future emissions and land use changes produced with integrated assessment models. In this paper, we describe ScenarioMIP's objectives, experimental design, and its relation to other activities within CMIP6. The ScenarioMIP design is one component of a larger scenario process that aims to facilitate a wide range of integrated studies across the climate science, integrated assessment modeling, and impacts, adaptation, and vulnerability communities, and will form an important part of the evidence base in the forthcoming Intergovernmental Panel on Climate Change (IPCC) assessments. At the same time, it will provide the basis for investigating a number of targeted science and policy questions that are especially relevant to scenario-based analysis, including the role of specific forcings such as land use and aerosols, the effect of a peak and decline in forcing, the consequences of scenarios that limit warming to below 2 °C, the relative contributions to uncertainty from scenarios, climate models, and internal variability, and long-term climate system outcomes beyond the 21st century. To serve this wide range of scientific communities and address these questions, a design has been identified consisting of eight alternative 21st century scenarios plus one large initial condition ensemble and a set of long-term extensions, divided into two tiers defined by relative priority. Some of these scenarios will also provide a basis for variants planned to be run in other CMIP6-Endorsed MIPs to investigate questions related to specific forcings. Harmonized, spatially explicit

  13. Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches

    PubMed Central

    Herzog, Fabian; Loza, Kateryna; Balog, Sandor; Clift, Martin J D; Epple, Matthias; Gehr, Peter; Petri-Fink, Alke

    2014-01-01

    Summary In the emerging market of nano-sized products, silver nanoparticles (Ag NPs) are widely used due to their antimicrobial properties. Human interaction with Ag NPs can occur through the lung, skin, gastrointestinal tract, and bloodstream. However, the inhalation of Ag NP aerosols is a primary concern. To study the possible effects of inhaled Ag NPs, an in vitro triple cell co-culture model of the human alveolar/airway barrier (A549 epithelial cells, human peripheral blood monocyte derived dendritic and macrophage cells) together with an air–liquid interface cell exposure (ALICE) system was used in order to reflect a real-life exposure scenario. Cells were exposed at the air–liquid interface (ALI) to 0.03, 0.3, and 3 µg Ag/cm2 of Ag NPs (diameter 100 nm; coated with polyvinylpyrrolidone: PVP). Ag NPs were found to be highly aggregated within ALI exposed cells with no impairment of cell morphology. Furthermore, a significant increase in release of cytotoxic (LDH), oxidative stress (SOD-1, HMOX-1) or pro-inflammatory markers (TNF-α, IL-8) was absent. As a comparison, cells were exposed to Ag NPs in submerged conditions to 10, 20, and 30 µg Ag/mL. The deposited dose per surface area was estimated by using a dosimetry model (ISDD) to directly compare submerged vs ALI exposure concentrations after 4 and 24 h. Unlike ALI exposures, the two highest concentrations under submerged conditions promoted a cytotoxic and pro-inflammatory response after 24 h. Interestingly, when cell cultures were co-incubated with lipopolysaccharide (LPS), no synergistic inflammatory effects were observed. By using two different exposure scenarios it has been shown that the ALI as well as the suspension conditions for the lower concentrations after 4 h, reflecting real-life concentrations of an acute 24 h exposure, did not induce any adverse effects in a complex 3D model mimicking the human alveolar/airway barrier. However, the highest concentrations used in the ALI setup, as well as

  14. Research on Digitized Scenario for Tactical Internet Simulative Training

    NASA Astrophysics Data System (ADS)

    Shen, Jian-Jun; Tian, Hua; Gan, Zhi-Chun

    The scenario of Tactical Internet simulative training can't be realized directly through the scenario systems and methods in existence. For solving this problem, firstly this paper introduced the new concept called digitized scenario, which can describe the meaning of scenario more exactly than the old simulation scenario. Secondly, this paper constructed the framework of digitized scenario, and it settled such issues as composition of digitized scenario system, scenario generating flow and data architecture. Thirdly, this paper built up the general data model for script situation, and it settled the problem of situation setting. Finally, this paper proposed the method of describing scenario files based on eXtensible Markup Language (XML), and it settled such problems as generation, verification and distribution of scenario files. The paper's work has been applied in the Tactical Internet simulative training system, and it also has good directive value to the developing of other communication network simulative training system.

  15. Selecting reasonable future land use scenarios

    SciTech Connect

    Allred, W.E.; Smith, R.W.

    1995-12-31

    This paper examines a process to help select the most reasonable future land use scenarios for hazardous waste and/or low-level radioactive waste disposal sites. The process involves evaluating future land use scenarios by applying selected criteria currently used by commercial mortgage companies to determine the feasibility of obtaining a loan for purchasing such land. The basis for the process is that only land use activities for which a loan can be obtained will be considered. To examine the process, a low-level radioactive waste site, the Radioactive Waste Management Complex at the Idaho National Engineering Laboratory, is used as an example. The authors suggest that the process is a very precise, comprehensive, and systematic (common sense) approach for determining reasonable future use of land. Implementing such a process will help enhance the planning, decisionmaking, safe management, and cleanup of present and future disposal facilities.

  16. Occupational health scenario of Indian informal sector

    PubMed Central

    NAG, Anjali; VYAS, Heer; NAG, Pranab

    2016-01-01

    Workers in the Indian informal sector are engaged with different occupations. These occupations involve varied work related hazards. These occupational hazards are a consequent risk to health. The study aimed to determine occupational health scenario in the Indian Informal sector. One thousand eleven hundred twenty two workers from five different occupations namely weaving (handloom and power loom), construction, transportation, tobacco processing and fish processing were assessed by interviewer administered health questionnaire. Workers suffered from musculo-skeletal complaints, respiratory health hazards, eye problems and skin related complaints. There was a high prevalence of self-reported occupational health problems in the selected sectors. The study finds that workers have occupational exposures to multiple hazards. The absence of protective guards aggrevate their health condition. The study attempts to draws an immediate attention on the existing health scenario of the Indian Informal sector. PMID:26903262

  17. The hexagon hypothesis: Six disruptive scenarios.

    PubMed

    Burtles, Jim

    2015-01-01

    This paper aims to bring a simple but effective and comprehensive approach to the development, delivery and monitoring of business continuity solutions. To ensure that the arguments and principles apply across the board, the paper sticks to basic underlying concepts rather than sophisticated interpretations. First, the paper explores what exactly people are defending themselves against. Secondly, the paper looks at how defences should be set up. Disruptive events tend to unfold in phases, each of which invites a particular style of protection, ranging from risk management through to business continuity to insurance cover. Their impact upon any business operation will fall into one of six basic scenarios. The hexagon hypothesis suggests that everyone should be prepared to deal with each of these six disruptive scenarios and it provides them with a useful benchmark for business continuity.

  18. Thermodynamical interpretation of gravity in braneworld scenarios

    SciTech Connect

    Sheykhi, Ahmad

    2009-05-15

    We study the thermodynamical properties of the apparent horizon in the various braneworld scenarios. First, we show that the Friedmann equations can be written directly in the form of the first law of thermodynamics, dE = T{sub h}dS{sub h}+WdV, at apparent horizon on the brane, regardless of whether there is the intrinsic curvature term on the brane or a Gauss-Bonnet term in the bulk. This procedure leads to extract an entropy expression in terms of horizon geometry associated with the apparent horizon. Then, we examine the time evolution of the total entropy, including the derived entropy of the apparent horizon and the entropy of the matter fields inside the apparent horizon. We find that the derived entropy of the apparent horizon on the brane satisfies the generalized second law of thermodynamics in braneworld scenarios. These results further support the idea that gravitation on a macroscopic scale is a manifestation of thermodynamics.

  19. Effective scenario of loop quantum cosmology.

    PubMed

    Ding, You; Ma, Yongge; Yang, Jinsong

    2009-02-06

    Semiclassical states in isotropic loop quantum cosmology are employed to show that the improved dynamics has the correct classical limit. The effective Hamiltonian for the quantum cosmological model with a massless scalar field is thus obtained, which incorporates also the next to leading order quantum corrections. The possibility that the higher order correction terms may lead to significant departure from the leading order effective scenario is revealed. If the semiclassicality of the model is maintained in the large scale limit, there are great possibilities for a k=0 Friedmann expanding universe to undergo a collapse in the future due to the quantum gravity effect. Thus the quantum bounce and collapse may contribute a cyclic universe in the new scenario.

  20. A new scenario framework for Climate Change Research: Scenario matrix architecture

    SciTech Connect

    Van Vuuren, Detlef; Kriegler, Elmar; O'Neill, Brian; Ebi, Kristie L.; Riahi, Keywan; Carter, Tim; Edmonds, James A.; Hallegatte, Stephane; Kram, Tom; Mathur, Ritu; Winkler, Harald

    2014-02-01

    In this paper, we present the scenario matrix architecture as part of the new scenario framework for climate change research. The matrix architecture focuses on a key question of current climate research, namely the identification of trade-offs and synergies (in terms of risks, costs and other consequences) of different adaptation and mitigation strategies. The framework has two main axes: 1) the level of forcing (as represented by the RCPs) and 2) different socio-economic reference pathways. The matrix can be used as a tool to guide new scenario development and analytical analysis. It can also be used as a heuristic tool for classifying new and existing scenarios for assessment. Key elements of the architecture, in particular the shared socio-economic reference pathways and the shared policy assumptions, are elaborated in other papers in this special issue.

  1. Land-Use Scenarios: National-Scale Housing-Density Scenarios Consistent with Climate Change Storylines (Final Report)

    EPA Science Inventory

    EPA announced the availability of the final report, Land-Use Scenarios: National-Scale Housing-Density Scenarios Consistent with Climate Change Storylines. This report describes the scenarios and models used to generate national-scale housing density scenarios for the con...

  2. Moving beyond ice loss scenarios for Antarctica

    NASA Astrophysics Data System (ADS)

    Little, C. M.; Oppenheimer, M.; Urban, N.

    2010-12-01

    Scenario-based projections of individual components of sea level change are difficult to reconcile with probability distributions for sea level at the global and/or local scale. It is also difficult to assess the origin of key subjective decisions in the construction of these scenarios. An example is the historical distinction between the sensitivity of the East and West Antarctic Ice Sheets to climatic forcing. Observations show that this distinction may not have a well-defined physical basis at smaller scales. Recent “kinematic” approaches impose increases in ice discharge at the scale of individual outlet glaciers, yet the criteria for inclusion in these scenarios are unclear and differ between studies. Projections of the response of sub-regions of ice sheets to climate forcing should be informed by key physical characteristics, which may include ocean and/or atmospheric boundary conditions, bedrock and embayment morphology, and the stress regime of the grounded ice. Here, we assess: 1) the volume of Antarctic ice that is included in ice loss scenarios under different plausible sets of assumptions, and 2) the impact of these assumptions on the Antarctic contribution to sea level change. In the short term, this approach may raise or lower upper bounds proposed by earlier studies, depending on the criteria and rates employed. Perhaps more importantly, it is a step towards a fully probabilistic methodology, informing the requirements for models that may be used in probabilistic projections. Updating is possible: key sources of uncertainty may be revisited as more is learned about future climate forcing and rate-limiting processes in ice sheets.

  3. CORSICA modelling of ITER hybrid operation scenarios

    NASA Astrophysics Data System (ADS)

    Kim, S. H.; Bulmer, R. H.; Campbell, D. J.; Casper, T. A.; LoDestro, L. L.; Meyer, W. H.; Pearlstein, L. D.; Snipes, J. A.

    2016-12-01

    The hybrid operating mode observed in several tokamaks is characterized by further enhancement over the high plasma confinement (H-mode) associated with reduced magneto-hydro-dynamic (MHD) instabilities linked to a stationary flat safety factor (q ) profile in the core region. The proposed ITER hybrid operation is currently aiming at operating for a long burn duration (>1000 s) with a moderate fusion power multiplication factor, Q , of at least 5. This paper presents candidate ITER hybrid operation scenarios developed using a free-boundary transport modelling code, CORSICA, taking all relevant physics and engineering constraints into account. The ITER hybrid operation scenarios have been developed by tailoring the 15 MA baseline ITER inductive H-mode scenario. Accessible operation conditions for ITER hybrid operation and achievable range of plasma parameters have been investigated considering uncertainties on the plasma confinement and transport. ITER operation capability for avoiding the poloidal field coil current, field and force limits has been examined by applying different current ramp rates, flat-top plasma currents and densities, and pre-magnetization of the poloidal field coils. Various combinations of heating and current drive (H&CD) schemes have been applied to study several physics issues, such as the plasma current density profile tailoring, enhancement of the plasma energy confinement and fusion power generation. A parameterized edge pedestal model based on EPED1 added to the CORSICA code has been applied to hybrid operation scenarios. Finally, fully self-consistent free-boundary transport simulations have been performed to provide information on the poloidal field coil voltage demands and to study the controllability with the ITER controllers. Extended from Proc. 24th Int. Conf. on Fusion Energy (San Diego, 2012) IT/P1-13.

  4. Necrotizing Fasciitis: An Emergency Medicine Simulation Scenario

    PubMed Central

    Galust, Henrik; Oliverio, Matthew H; Giorgio, Daniel J; Espinal, Alexis M

    2016-01-01

    Necrotizing fasciitis (NF) is a rare and rapidly progressing life-threatening infectious process. By progressing through a simulation involving a patient with NF and participating in a post-scenario debriefing, learners will gain the necessary skills and knowledge to properly diagnose and manage patients with NF. Learners are taught to initiate appropriate and timely treatment and to advocate on behalf of their patient after inappropriate pushback from consultants to improve outcomes. PMID:27733963

  5. A tilted cold dark matter cosmological scenario

    NASA Technical Reports Server (NTRS)

    Cen, Renyue; Gnedin, Nickolay Y.; Kofman, Lev A.; Ostriker, Jeremiah P.

    1992-01-01

    A new cosmological scenario based on CDM but with a power spectrum index of about 0.7-0.8 is suggested. This model is predicted by various inflationary models with no fine tuning. This tilted CDM model, if normalized to COBE, alleviates many problems of the standard CDM model related to both small-scale and large-scale power. A physical bias of galaxies over dark matter of about two is required to fit spatial observations.

  6. Arctic shipping emissions inventories and future scenarios

    NASA Astrophysics Data System (ADS)

    Corbett, J. J.; Lack, D. A.; Winebrake, J. J.; Harder, S.; Silberman, J. A.; Gold, M.

    2010-04-01

    The Arctic is a sensitive region in terms of climate change and a rich natural resource for global economic activity. Arctic shipping is an important contributor to the region's anthropogenic air emissions, including black carbon - a short-lived climate forcing pollutant especially effective in accelerating the melting of ice and snow. These emissions are projected to increase as declining sea ice coverage due to climate change allows for increased shipping activity in the Arctic. To understand the impacts of these increased emissions, scientists and modelers require high-resolution, geospatial emissions inventories that can be used for regional assessment modeling. This paper presents 5 km×5 km Arctic emissions inventories of important greenhouse gases, black carbon and other pollutants under existing and future (2050) scenarios that account for growth of shipping in the region, potential diversion traffic through emerging routes, and possible emissions control measures. Short-lived forcing of ~4.5 gigagrams of black carbon from Arctic shipping may increase climate forcing; a first-order calculation of global warming potential due to 2030 emissions in the high-growth scenario suggests that short-lived forcing of ~4.5 gigagrams of black carbon from Arctic shipping may increase climate forcing due to Arctic ships by at least 17% compared to warming from these vessels' CO2 emissions (~42 000 gigagrams). The paper also presents maximum feasible reduction scenarios for black carbon in particular. These emissions reduction scenarios will enable scientists and policymakers to evaluate the efficacy and benefits of technological controls for black carbon, and other pollutants from ships.

  7. Alternative World Scenarios for Strategic Planning

    DTIC Science & Technology

    1988-01-20

    budgetary investments in social and welfare programs than in programs for defense or for foreign economic and military aid. For the most part, U.S. and other...World. This scenario describes a productive economic world where U.S. political leadership favors social and welfare investments over those of...directed toward internal economic and social development programs which began in the late 1980s. Although its international trade and economic investment

  8. Probabilistic Climate Scenario Information for Risk Assessment

    NASA Astrophysics Data System (ADS)

    Dairaku, K.; Ueno, G.; Takayabu, I.

    2014-12-01

    Climate information and services for Impacts, Adaptation and Vulnerability (IAV) Assessments are of great concern. In order to develop probabilistic regional climate information that represents the uncertainty in climate scenario experiments in Japan, we compared the physics ensemble experiments using the 60km global atmospheric model of the Meteorological Research Institute (MRI-AGCM) with multi-model ensemble experiments with global atmospheric-ocean coupled models (CMIP3) of SRES A1b scenario experiments. The MRI-AGCM shows relatively good skills particularly in tropics for temperature and geopotential height. Variability in surface air temperature of physical ensemble experiments with MRI-AGCM was within the range of one standard deviation of the CMIP3 model in the Asia region. On the other hand, the variability of precipitation was relatively well represented compared with the variation of the CMIP3 models. Models which show the similar reproducibility in the present climate shows different future climate change. We couldn't find clear relationships between present climate and future climate change in temperature and precipitation. We develop a new method to produce probabilistic information of climate change scenarios by weighting model ensemble experiments based on a regression model (Krishnamurti et al., Science, 1999). The method can be easily applicable to other regions and other physical quantities, and also to downscale to finer-scale dependent on availability of observation dataset. The prototype of probabilistic information in Japan represents the quantified structural uncertainties of multi-model ensemble experiments of climate change scenarios. Acknowledgments: This study was supported by the SOUSEI Program, funded by Ministry of Education, Culture, Sports, Science and Technology, Government of Japan.

  9. CP violation in heavy MSSM Higgs scenarios

    DOE PAGES

    Carena, M.; Ellis, J.; Lee, J. S.; ...

    2016-02-18

    We introduce and explore new heavy Higgs scenarios in the Minimal Supersymmetric Standard Model (MSSM) with explicit CP violation, which have important phenomenological implications that may be testable at the LHC. For soft supersymmetry-breaking scales MS above a few TeV and a charged Higgs boson mass MH+ above a few hundred GeV, new physics effects including those from explicit CP violation decouple from the light Higgs boson sector. However, such effects can significantly alter the phenomenology of the heavy Higgs bosons while still being consistent with constraints from low-energy observables, for instance electric dipole moments. To consider scenarios with amore » charged Higgs boson much heavier than the Standard Model (SM) particles but much lighter than the supersymmetric particles, we revisit previous calculations of the MSSM Higgs sector. We compute the Higgs boson masses in the presence of CP violating phases, implementing improved matching and renormalization-group (RG) effects, as well as two-loop RG effects from the effective two-Higgs Doublet Model (2HDM) scale MH± to the scale MS. Here, we illustrate the possibility of non-decoupling CP-violating effects in the heavy Higgs sector using new benchmark scenarios named.« less

  10. CP violation in heavy MSSM Higgs scenarios

    SciTech Connect

    Carena, M.; Ellis, J.; Lee, J. S.; Pilaftsis, A.; Wagner, C. E. M.

    2016-02-18

    We introduce and explore new heavy Higgs scenarios in the Minimal Supersymmetric Standard Model (MSSM) with explicit CP violation, which have important phenomenological implications that may be testable at the LHC. For soft supersymmetry-breaking scales MS above a few TeV and a charged Higgs boson mass MH+ above a few hundred GeV, new physics effects including those from explicit CP violation decouple from the light Higgs boson sector. However, such effects can significantly alter the phenomenology of the heavy Higgs bosons while still being consistent with constraints from low-energy observables, for instance electric dipole moments. To consider scenarios with a charged Higgs boson much heavier than the Standard Model (SM) particles but much lighter than the supersymmetric particles, we revisit previous calculations of the MSSM Higgs sector. We compute the Higgs boson masses in the presence of CP violating phases, implementing improved matching and renormalization-group (RG) effects, as well as two-loop RG effects from the effective two-Higgs Doublet Model (2HDM) scale MH± to the scale MS. Here, we illustrate the possibility of non-decoupling CP-violating effects in the heavy Higgs sector using new benchmark scenarios named.

  11. Glacial CO2 Cycles: A Composite Scenario

    NASA Astrophysics Data System (ADS)

    Broecker, W. S.

    2015-12-01

    There are three main contributors to the glacial drawdown of atmospheric CO2 content: starvation of the supply of carbon to the ocean-atmosphere reservoir, excess CO2 storage in the deep sea, and surface-ocean cooling. In this talk, I explore a scenario in which all three play significant roles. Key to this scenario is the assumption that deep ocean storage is related to the extent of nutrient stratification of the deep Atlantic. The stronger this stratification, the larger the storage of respiration CO2. Further, it is my contention that the link between Milankovitch insolation cycles and climate is reorganizations of the ocean's thermohaline circulation leading to changes in the deep ocean's CO2 storage. If this is the case, the deep Atlantic d13C record kept in benthic foraminifera shells tells us that deep ocean CO2 storage follows Northern Hemisphere summer insolation cycles and thus lacks the downward ramp so prominent in the records of sea level, benthic 18O and CO2. Rather, the ramp is created by the damping of planetary CO2 emissions during glacial time intervals. As it is premature to present a specific scenario, I provide an example as to how these three contributors might be combined. As their magnitudes and shapes remain largely unconstrained, the intent of this exercise is to provoke creative thinking.

  12. Generic scenario for the impact of cooling lubricants into the hydrosphere.

    PubMed

    Gräfen, Melanie; Hesse, Kathrin; Pollkläsner, Detlef; Baumann, Werner

    2003-01-01

    According to directive 93/67/EEC of the European Commission, this paper deals with the generic exposition evaluation of the environmental concentration of cooling Lubricant chemicals from the metal working industry into the hydrosphere. After considering the relevant life-cycle steps and the selection of a representative point source for the 'reasonable worst case', the emission per day Elocal(water) is determined. It leads to the predicted environmental concentration (PEClocal(water)) for the local stage in the compartment water. In order to gain the PEClocal(water) for an example--a corrosion inhibitor as additive in a cooling lubricant--, the relevant emission paths and the corresponding representative point source are described for the reasonable worst case. For non-water-miscible cooling lubricants, none of the operations in the life cycle leads to a release into the compartment water. To evaluate the hazard potential for cooling lubricant chemicals, the complete risk assessment has to be done. Also, the assessment has to be done for all high production volume chemicals, new substances and existing hazard chemicals. This means that even industrial categories like chemicals used in the textile industry or biocides and others have to be evaluated.

  13. Deforestation scenarios for the Bolivian lowlands.

    PubMed

    Tejada, Graciela; Dalla-Nora, Eloi; Cordoba, Diana; Lafortezza, Raffaele; Ovando, Alex; Assis, Talita; Aguiar, Ana Paula

    2016-01-01

    Tropical forests in South America play a key role in the provision of ecosystem services such as carbon sinks, biodiversity conservation, and global climate regulation. In previous decades, Bolivian forests have mainly been deforested by the expansion of agricultural frontier development, driven by the growing demands for beef and other productions. In the mid-2000s the Movimiento al Socialismo (MAS) party rose to power in Bolivia with the promise of promoting an alternative development model that would respect the environment. The party passed the world's first laws granting rights to the environment, which they termed Mother Earth (Law No. 300 of 2012), and proposed an innovative framework that was expected to develop radical new conservation policies. The MAS conservationist discourse, policies, and productive practices, however, have since been in permanent tension. The government continues to guarantee food production through neo-extractivist methods by promoting the notion to expand agriculture from 3 to 13 million ha, risking the tropical forests and their ecosystem services. These actions raise major environmental and social concerns, as the potential impacts of such interventions are still unknown. The objective of this study is to explore an innovative land use modeling approach to simulate how the growing demand for land could affect future deforestation trends in Bolivia. We use the LuccME framework to create a spatially-explicit land cover change model and run it under three different deforestation scenarios, spanning from the present-2050. In the Sustainability scenario, deforestation reaches 17,703,786 ha, notably in previously deforested or degraded areas, while leaving forest extensions intact. In the Middle of the road scenario, deforestation and degradation move toward new or paved roads spreading across 25,698,327 ha in 2050, while intact forests are located in Protected Areas (PAs). In the Fragmentation scenario, deforestation expands to almost

  14. Occupational Neurobrucellosis Mimicking a Brain Tumor: A Case Report and Review of the Literature

    PubMed Central

    Abdulghani, Dina; Farhan, Roiya; Algahtani, Raghad

    2017-01-01

    Brucellosis is a zoonotic bacterial infection which is transmitted to humans from infected animals and is endemic in many parts of the world including Saudi Arabia. In this article, we report a case of occupational neurobrucellosis that presented with a space-occupying lesion mimicking a brain tumor. We stress on the importance of obtaining detailed social history including occupation to reach the diagnosis in several conditions including brucellosis. We also stress on taking universal precautions when handling any specimens. It may be advisable that manipulation of all unknown specimens arriving at the laboratory should occur in biological safety cabinet until a highly infectious organism is ruled out. Neurobrucellosis should be included in the differential diagnosis in patients presenting with solitary mass lesion mimicking brain tumor especially in endemic areas or high occupational risk group. PMID:28299214

  15. Mimicking the human smell sensing mechanism with an artificial nose platform.

    PubMed

    Lee, Sang Hun; Kwon, Oh Seok; Song, Hyun Seok; Park, Seon Joo; Sung, Jong Hwan; Jang, Jyongsik; Park, Tai Hyun

    2012-02-01

    Sensing smell is a highly complex biological process, and characterizing and mimicking the interaction between the olfactory receptor (OR) protein and its ligands is extremely challenging. Herein, we report a highly sensitive and selective human nose-like nanobioelectronic nose (nbe-nose), which responds to gaseous odorants sensitively and selectively, has a signal specificity pattern similar to that in the cellular signal transduction pathway, and maintains an antagonistic behavior similar to the human nose. The human olfaction mechanism was mimicked by using carboxylated polypyrrole nanotubes (CPNTs) functionalized with human OR protein. The nbe-nose was able to detect gaseous odorants at a concentration as low as 0.02 parts-per-trillion (ppt), which was comparable to a highly trained, human expert's nose. The nbe-nose can be used scientifically for smell mechanism studies. It can be also applied to various fields that rely on smell monitoring for industrial and public purposes.

  16. Structure-Based Design of Inhibitors of Protein–Protein Interactions: Mimicking Peptide Binding Epitopes

    PubMed Central

    Pelay-Gimeno, Marta; Glas, Adrian; Koch, Oliver; Grossmann, Tom N

    2015-01-01

    Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus making the development of PPI inhibitors extremely valuable. The identification of selective inhibitors is challenging because of the shallow and extended nature of PPI interfaces. Inhibitors can be obtained by mimicking peptide binding epitopes in their bioactive conformation. For this purpose, several strategies have been evolved to enable a projection of side chain functionalities in analogy to peptide secondary structures, thereby yielding molecules that are generally referred to as peptidomimetics. Herein, we introduce a new classification of peptidomimetics (classes A–D) that enables a clear assignment of available approaches. Based on this classification, the Review summarizes strategies that have been applied for the structure-based design of PPI inhibitors through stabilizing or mimicking turns, β-sheets, and helices. PMID:26119925

  17. The Face of the Chameleon: The Experience of Facial Mimicry for the Mimicker and the Mimickee.

    PubMed

    Kulesza, Wojciech Marek; Cisłak, Aleksandra; Vallacher, Robin R; Nowak, Andrzej; Czekiel, Martyna; Bedynska, Sylwia

    2015-01-01

    This research addressed three questions concerning facial mimicry: (a) Does the relationship between mimicry and liking characterize all facial expressions, or is it limited to specific expressions? (b) Is the relationship between facial mimicry and liking symmetrical for the mimicker and the mimickee? (c) Does conscious mimicry have consequences for emotion recognition? A paradigm is introduced in which participants interact over a computer setup with a confederate whose prerecorded facial displays of emotion are synchronized with participants' behavior to create the illusion of social interaction. In Experiment 1, the confederate did or did not mimic participants' facial displays of various subsets of basic emotions. Mimicry promoted greater liking for the confederate regardless of which emotions were mimicked. Experiment 2 reversed these roles: participants were instructed to mimic or not to mimic the confederate's facial displays. Mimicry did not affect liking for the confederate but it did impair emotion recognition.

  18. Discrimination of Umami Tastants Using Floating Electrode-Based Bioelectronic Tongue Mimicking Insect Taste Systems.

    PubMed

    Lee, Minju; Jung, Je Won; Kim, Daesan; Ahn, Young-Joon; Hong, Seunghun; Kwon, Hyung Wook

    2015-12-22

    We report a floating electrode-based bioelectronic tongue mimicking insect taste systems for the detection and discrimination of umami substances. Here, carbon nanotube field-effect transistors with floating electrodes were hybridized with nanovesicles containing honeybee umami taste receptor, gustatory receptor 10 of Apis mellifera (AmGr10). This strategy enables us to discriminate between l-monosodium glutamate (MSG), best-known umami tastant, and non-umami substances with a high sensitivity and selectivity. It could also be utilized for the detection of MSG in liquid food such as chicken stock. Moreover, we demonstrated the synergism between MSG and disodium 5'-inosinate (IMP) for the umami taste using this platform. This floating electrode-based bioelectronic tongue mimicking insect taste systems can be a powerful platform for various applications such as food screening, and it also can provide valuable insights on insect taste systems.

  19. Retroperitoneal mucinous cystadenoma of the appendix mimicking hydatid cyst: A case report

    PubMed Central

    Sikar, Hasan Ediz; Çetin, Kenan; Gündoğan, Ersin; Gündoğan, Gökçen Alinak; Kaptanoğlu, Levent

    2016-01-01

    Appendiceal mucocele is a cystic dilatation of the appendix due to abnormal appendiceal mucinous secretion. Cystadenoma of the appendix is one of the most common causes and is encountered in 0.6% of all appendectomy specimens. The diagnosis may be difficult due to the asymptomatic nature of the disease; pain in the right lower quadrant may be the only symptom. Complex ovarian cyst, urolithiasis or cystic hydatid disease of the liver have been reported as mimicking appendiceal mucocele in the literature. In this study, we present a case of mucinous cystadenoma of the appendix mimicking retroperitoneal hydatid cyst in a 59-year-old woman. The patient was treated with laparoscopic appendectomy with partial resection of the caecum following laparoscopic exploration. PMID:27446577

  20. Synthetic mimicking of plant oils and comparison with naturally grown products in polyurethane synthesis.

    PubMed

    Coles, Stuart R; Barker, Guy; Clark, Andrew J; Kirwan, Kerry; Jacobs, Daniel; Makenji, Kylash; Pink, David

    2008-06-11

    The use of plant oils as industrial feedstocks can often be hampered by their lack of optimization towards a particular process, as well as their development being risky; growing suitable volumes of crops to test can take up to five years. To circumvent this, we aimed to discover a method that would mimic plant oil profiles in the laboratory, and show that they exhibited similar properties to the naturally grown plant oils in a given process. Using the synthesis of polyurethanes as an example, we have synthesized six different polymers and demonstrated that plant oils will produce polymers with similar physical properties to those oils mimicked in the laboratory. The use of this mimicking process can be extended to other types of polymers to obtain a method for predicting the properties of a given material based on the plant oil composition of a crop before it is grown in bulk.

  1. Super-Anticoagulant Heparin-Mimicking Hydrogel Thin Film Attached Substrate Surfaces to Improve Hemocompatibility.

    PubMed

    He, Min; Cui, Xiaofei; Jiang, Huiyi; Huang, Xuelian; Zhao, Weifeng; Zhao, Changsheng

    2017-02-01

    In this study, heparin-mimicking hydrogel thin films are covalently attached onto poly(ether sulfone) membrane surfaces to improve anticoagulant property. The hydrogel films display honeycomb-like porous structure with well controlled thickness and show long-term stability. After immobilizing the hydrogel films, the membranes show excellent anticoagulant property confirmed by the activated partial thromboplastin time values exceeding 600 s. Meanwhile, the thrombin time values increase from 20 to 61 s as the sodium allysulfonate proportions increase from 0 to 80 mol%. In vitro investigations of protein adsorption and blood-related complement activation also confirm that the membranes exhibit super-anticoagulant property. Furthermore, gentamycin sulfate is loaded into the hydrogel films, and the released drug shows significant inhibition toward E. coli bacteria. It is believed that the surface attached heparin-mimicking hydrogel thin films may show high potential for the applications in various biological fields, such as blood contacting materials and drug loading materials.

  2. Peripheral Odontogenic Fibroma: A Rare Tumor mimicking a Gingival Reactive Lesion

    PubMed Central

    Khot, Komal; Bagri-Manjrekar, Kriti; Khot, Paresh

    2017-01-01

    Gingival growths are one of the most frequently encountered lesions in the oral cavity. A plethora of lesions can be seen having similar clinical presentation, making diagnosis a dilemma. Peripheral odontogenic tumors are rare neoplasms to occur on gingiva, the most common among them being the peripheral odontogenic fibroma (POdF). The POdF is a benign, slow-growing, exophytic lesion. Although considered to have a recurrence potential after excision, the actual recurrence rate is not known due to paucity of reported cases. Presented here is a case of a rare neoplasm mimicking an inflammatory gingival lesion with review of the available literature. How to cite this article Khot K, Deshmane S, Bagri-Manjrekar K, Khot P. Peripheral Odontogenic Fibroma: A Rare Tumor mimicking a Gingival Reactive Lesion. Int J Clin Pediatr Dent 2017;10(1):103-106. PMID:28377665

  3. Possible neuro-Sweet disease mimicking brain tumor in the medulla oblongata--case report.

    PubMed

    Akiba, Chihiro; Esaki, Takanori; Ando, Maya; Furuya, Tsuyoshi; Noda, Kazuyuki; Nakao, Yasuaki; Yamamoto, Takuji; Okuma, Yasuyuki; Mori, Kentaro

    2011-01-01

    A 62-year-old male presented with a rare case of possible neuro-Sweet Disease (NSD) mimicking brain tumor in the medulla oblongata, manifesting as numbness in the bilateral upper and lower extremities, gait disturbance, dysarthria, and swallowing disturbance which gradually deteriorated over 3 months. Magnetic resonance imaging showed a mass lesion in the medulla oblongata, extending to the upper cervical cord with rim enhancement by gadolinium. The preoperative diagnosis was brain tumor, such as glioma, or inflammatory disease. His neurological symptoms gradually deteriorated, so biopsy was performed through the midline suboccipital approach. Histological examination showed infiltration of inflammatory cells, mainly lymphocytes and macrophages. Human leukocyte antigen typing showed Cw1 and B54 which strongly suggested possible NSD. Steroid pulse therapy was started after surgery and the clinical symptoms improved. Neurosurgeons should be aware of inflammatory disorders such as NSD mimicking brain tumor.

  4. Massive retroperitoneal tubercular abscess mimicking a leaking abdominal aortic aneurysm: a case report

    PubMed Central

    Singh, Pankaj K; Azam, Amir; Singh, Vinay K; Tomar, Juhi; Mishra, Alka; Singh, Kuldeep K; Gupta, Sanjeev

    2008-01-01

    In spite of being a common diagnosis in the patients of Asian origin, atypical presentations of tuberculosis may pose diagnostic challenges. We report a huge prevertebral abscess in a 30-year-old female, mimicking a leaking aortic aneurysm. The patient was managed successfully by emergency decompression and stabilization. The issues related to poor patient compliance to chemotherapy and management of atypical presentations of spinal tuberculosis are discussed here. PMID:18854051

  5. Looks can be deceiving: three cases of neurological diseases mimicking Guillain-Barrè syndrome.

    PubMed

    Sciacca, G; Nicoletti, A; Fermo, S Lo; Mostile, G; Giliberto, C; Zappia, Mario

    2016-04-01

    Guillain-Barrè syndrome (GBS) is an acute, paralyzing, inflammatory peripheral nerve disease, featured by monophasic disease course, symmetrical limb weakness and areflexia. Several pathologies can mimic the clinical presentation of GBS, making hard the differential diagnosis for patients complaining of acute flaccid paralysis. In this paper we describe three cases of different neurological diseases presenting with acute motor symptoms mimicking GBS, reviewing the relevant literature on misdiagnosis of GBS.

  6. Neglected Thorn Injury Mimicking Soft Tissue Mass in a Child: A Case Report

    PubMed Central

    Gupta, Mayank; Kumar, Dharmendra; Naik, Ananta Kumar; Arya, Rajendera Kumar

    2015-01-01

    Thorn injuries are common especially in rural areas. The diagnosis of such in children is always missed. An untreated retained thorn may cause late soft tissue and osseous complications. Herein, we report a case of neglected thorn injury mimicking soft tissue mass in an 11-year-old male child. The presence of the thorn was confirmed with ultrasound scan and computerized tomography. The child was successfully managed with removal of thorn with excision of foreign body granuloma. PMID:26155524

  7. Perforated appendix in hernial sac mimicking torsion of undescended testis in a neonate.

    PubMed

    Kumar, Renu; Mahajan, J K; Rao, K L N

    2008-04-01

    In pediatric surgical practice, finding of the vermiform appendix in an inguinal hernia sac is not that uncommon; however, a perforation is rare. There are only a few case reports of a perforated appendix with periappendicular abscess in the inguinal hernial sac in a neonate. We report an unusual case of inguinal hernia containing a perforated appendix that was clinically mimicking testicular torsion of the undescended testis.

  8. Syphilis Mimicking Other Dermatological Diseases: Reactive Arthritis and Mucha-Habermann Disease

    PubMed Central

    da Silva Carneiro, Sueli Coelho; Pirmez, Rodrigo; de Hollanda, Taciana Rocha; Cuzzi, Tullia; Ramos-e-Silva, Marcia

    2013-01-01

    The authors present two cases of syphilis: one mimicking reactive arthritis and the other Mucha-Habermann disease. Both reports illustrate syphilis as ‘the great imitator’, a description given by Sir William Osler, and call attention to the strong need for awareness among physicians of all specialties, especially the younger ones, who are not used to seeing this increasingly prevalent disease, as it once was in the past. PMID:23467097

  9. Tissue Boundaries: Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces (Adv. Healthcare Mater. 15/2016).

    PubMed

    Sapudom, Jiranuwat; Rubner, Stefan; Martin, Steve; Pompe, Tilo

    2016-08-01

    Engineering interfaces of extracellular compartments mimicking native tissues is key to study cell behavior in a physiologically relevant context and for a successful translation of these new biomaterials engineering principles in regenerative and therapeutic applications. Tilo Pompe and co-workers demonstrate a strategy to engineer multiparameter matrix interfaces using a sequential reconstitution of two well-defined Collagen I based matrices on page 1861. Such matrix interfaces trigger cell migration directionality normal to the interface plane in dependence on matrix pore size.

  10. A Retroperitoneal Isolated Enteric Duplication Cyst Mimicking a Teratoma: A Case Report and Literature Review

    PubMed Central

    Momosaka, Daichi; Ushijima, Yasuhiro; Asayama, Yoshiki; Ishigami, Kousei; Takayama, Yukihisa; Okamoto, Daisuke; Fujita, Nobuhiro; Ikeda, Tetsuo; Uchida, Keiichiro; Sugimoto, Masaaki; Kohashi, Kenichi; Honda, Hiroshi

    2016-01-01

    Enteric duplication cysts lacking anatomic association with the gastrointestinal tract are called isolated enteric duplication cysts (IEDCs). We present an atypical case of a retroperitoneal IEDC with a tortuous tubular complex shape that enfolded the surrounding retroperitoneal fat and mimicked a retroperitoneal teratoma. Multiplanar reconstruction images should be used to evaluate such a lesion correctly. A tortuous tubular complex shape could be a key finding to differentiate from other retroperitoneal cysts. PMID:28083153

  11. Medulla oblongata tuberculoma mimicking metastasis presenting with stroke-like symptoms.

    PubMed

    Donmez, Fuldem Yildirim; Coskun, Mehmet; Guven, Gulnur

    2009-08-01

    Tuberculomas are common forms of central nervous system tuberculosis, presenting as space-occupying-lesions. Brainstem tuberculomas are rare among all intracranial tuberculomas. In old patients, in the absence of tuberculosis history, diagnosis may be challenging. In this case, we present a 70-year-old patient, with bladder cancer, without known tuberculosis who presented with stroke-like symptoms, clinically. Diffusion-weighted imaging revealed no finding of stroke, however, a medulla oblongata tuberculoma, mimicking metastasis was evident on MRI.

  12. Mixed capillary-cavernous extramedullary intradural hemangioma of the spinal cord mimicking meningioma: Case report.

    PubMed

    Alobaid, Abdullah; Bennardo, Michael Ross; Cenic, Aleksa; Lach, Boleslaw

    2015-06-01

    Hemangiomas are customarily described as low-grade vascular tumors most often located in the head and neck, but on rare occasions occurring in the intradural space of the spine. The different subtypes of hemangiomas can be distinguished histologically as capillary, cavernous, or mixed types. We describe a rare case of a mixed capillary-cavernous extramedullary intradural hemangioma of the thoracic spinal cord, mimicking meningioma radiologically.

  13. MRI of the small-bowel: how to differentiate primary neoplasms and mimickers

    PubMed Central

    Masselli, G; Colaiacomo, M C; Marcelli, G; Bertini, L; Casciani, E; Laghi, F; D'Amico, P; Caprasecca, S; Polettini, E; Gualdi, G

    2012-01-01

    MRI of the gastrointestinal tract is gaining clinical acceptance and is increasingly used to evaluate patients with suspected small-bowel diseases. MRI may be performed with enterography or enteroclysis, both of which combine the advantages of cross-sectional imaging with those of conventional enteroclysis. In this paper, MRI features of primary small-bowel neoplasms, the most important signs for differential diagnosis and the diseases that can be considered as mimickers of small-bowel neoplasms, are discussed. PMID:22422388

  14. Cutaneous metastasis of ovarian carcinoma with shadow cells mimicking a primary pilomatrical neoplasm.

    PubMed

    Lalich, Daniel; Tawfik, Ossama; Chapman, Julia; Fraga, Garth

    2010-07-01

    Shadow cells are characteristic of pilomatricoma, although they have been described in other cutaneous and visceral neoplasms, particularly endometrioid adenocarcinomas of the female genital tract. We describe a metastasis of an ovarian endometrioid adenocarcinoma with shadow cells to the skin that was initially misinterpreted as a pilomatricoma. We compare the histology of the ovarian neoplasm to 21 pilomatricomas. This is the first reported case of a cutaneous metastasis of a visceral neoplasm mimicking a primary pilomatrical neoplasm.

  15. Abdominal varices mimicking an acute gastrointestinal hemorrhage during technetium-99m red blood cell scintigraphy

    SciTech Connect

    Moreno, A.J.; Byrd, B.F.; Berger, D.E.; Turnbull, G.L.

    1985-04-01

    Abdominal varices consisting of a caput medusae and dilated mesenteric veins resulted in pooling of Tc-99m tagged red blood cells (RBC) within these dilated vessels in a 57-year-old man with severe Laennec's cirrhosis. The atypical radiotracer localization within the abdomen mimicked an acute gastrointestinal hemorrhage. Clinical suspicion and careful evaluation of scintigraphic gastrointestinal bleeding studies will avoid false-positive interpretations.

  16. Multi-modality gellan gum-based tissue-mimicking phantom with targeted mechanical, electrical, and thermal properties

    NASA Astrophysics Data System (ADS)

    Chen, Roland K.; Shih, A. J.

    2013-08-01

    This study develops a new class of gellan gum-based tissue-mimicking phantom material and a model to predict and control the elastic modulus, thermal conductivity, and electrical conductivity by adjusting the mass fractions of gellan gum, propylene glycol, and sodium chloride, respectively. One of the advantages of gellan gum is its gelling efficiency allowing highly regulable mechanical properties (elastic modulus, toughness, etc). An experiment was performed on 16 gellan gum-based tissue-mimicking phantoms and a regression model was fit to quantitatively predict three material properties (elastic modulus, thermal conductivity, and electrical conductivity) based on the phantom material's composition. Based on these material properties and the regression model developed, tissue-mimicking phantoms of porcine spinal cord and liver were formulated. These gellan gum tissue-mimicking phantoms have the mechanical, thermal, and electrical properties approximately equivalent to those of the spinal cord and the liver.

  17. IgG4-related Kidney Disease Mimicking Malignant Ureter Tumor: Case Report and Literature Review.

    PubMed

    Lei, Wen-Hui; Xin, Jun; Shao, Chu-Xiao; Mao, Ming-Feng; Zhu, Chao-Yong; Wu, Chui-Fen; Jin, Lie

    2016-01-01

    Immunoglobulin G4-related disease is a recently recognized systemic disease that can affect any organ or tissue in the body, including the kidneys. IgG4-related kidney disease (IgG4-RKD) is an important part of immunoglobulin G4-related disease. The most common renal manifestation of IgG4-RKD is tubulointerstitial nephritis and glomerular lesions. There, however, is few case of IgG4-RKD mimicking malignant ureter tumor leading to severe hydronephrosis. We herein report an unusual case of IgG4-RKD mimicking malignancy.A 66-year-old Asian man presented to the nephrologist with soreness of loins, anorexia, and acute kidney injury in 2010. His renal function spontaneously improved after 2 weeks' hemodialysis without systemic steroid therapy. Four years later, he presented to the urologist with severe left hydronephrosis because of marked thickness of the left ureter wall. As a ureteral malignancy could not be ruled out, laparoscopic nephroureterectomy was performed.IgG4-related kidney disease was confirmed by the histologic examination. Then, repeat laboratory test showed almost complete recovery of renal function after initiation of steroidal therapy.This case highlights the rare possibility of IgG4-RKD mimicking malignant ureter tumor. Nephrologist and pathologists should be aware of the possibility that hydronephrosis with ureter obstruction may be involved in IgG4-RKD.

  18. Antimicrobial Peptide Mimicking Primary Amine and Guanidine Containing Methacrylamide Copolymers Prepared by Raft Polymerization

    PubMed Central

    Exley, Sarah E.; Paslay, Lea C.; Sahukhal, Gyan S.; Abel, Brooks A.; Brown, Tyler D.; McCormick, Charles L.; Heinhorst, Sabine; Koul, Veena; Choudhary, Veena; Elasri, Mohamed O.; Morgan, Sarah E.

    2016-01-01

    Naturally occurring antimicrobial peptides (AMPs) display the ability to eliminate a wide variety of bacteria, without toxicity to the host eukaryotic cells. Synthetic polymers containing moieties mimicking lysine and arginine components found in AMPs have been reported to show effectiveness against specific bacteria, with the mechanism of activity purported to depend on the nature of the amino acid mimic. In an attempt to incorporate the antimicrobial activity of both amino acids into a single water-soluble copolymer, a series of copolymers containing lysine mimicking aminopropyl methacrylamide (APMA) and arginine mimicking guanadinopropyl methacrylamide (GPMA) were prepared via aqueous RAFT polymerization. Copolymers were prepared with varying ratios of the comonomers, with degree of polymerization of 35–40 and narrow molecular weight distribution to simulate naturally occurring AMPs. Antimicrobial activity was determined against Gram-negative and Gram-positive bacteria under conditions with varying salt concentration. Toxicity to mammalian cells was assessed by hemolysis of red blood cells and MTT assays of MCF-7 cells. Antimicrobial activity was observed for APMA homopolymer and copolymers with low concentrations of GPMA against all bacteria tested, with low toxicity toward mammalian cells. PMID:26558609

  19. Riparian vegetation structure under desertification scenarios

    NASA Astrophysics Data System (ADS)

    Rosário Fernandes, M.; Segurado, Pedro; Jauch, Eduardo; Ferreira, M. Teresa

    2015-04-01

    Riparian areas are responsible for many ecological and ecosystems services, including the filtering function, that are considered crucial to the preservation of water quality and social benefits. The main goal of this study is to quantify and understand the riparian variability under desertification scenario(s) and identify the optimal riparian indicators for water scarcity and droughts (WS&D), henceforth improving river basin management. This study was performed in the Iberian Tâmega basin, using riparian woody patches, mapped by visual interpretation on Google Earth imagery, along 130 Sampling Units of 250 m long river stretches. Eight riparian structural indicators, related with lateral dimension, weighted area and shape complexity of riparian patches were calculated using Patch Analyst extension for ArcGis 10. A set of 29 hydrological, climatic, and hydrogeomorphological variables were computed, by a water modelling system (MOHID), using monthly meteorological data between 2008 and 2014. Land-use classes were also calculated, in a 250m-buffer surrounding each sampling unit, using a classification based system on Corine Land Cover. Boosted Regression Trees identified Mean-width (MW) as the optimal riparian indicator for water scarcity and drought, followed by the Weighted Class Area (WCA) (classification accuracy =0.79 and 0.69 respectively). Average Flow and Strahler number were consistently selected, by all boosted models, as the most important explanatory variables. However, a combined effect of hidrogeomorphology and land-use can explain the high variability found in the riparian width mainly in Tâmega tributaries. Riparian patches are larger towards Tâmega river mouth although with lower shape complexity, probably related with more continuous and almost monospecific stands. Climatic, hydrological and land use scenarios, singly and combined, were used to quantify the riparian variability responding to these changes, and to assess the loss of riparian

  20. Underground infrastructure damage for a Chicago scenario

    SciTech Connect

    Dey, Thomas N; Bos, Rabdall J

    2011-01-25

    Estimating effects due to an urban IND (improvised nuclear device) on underground structures and underground utilities is a challenging task. Nuclear effects tests performed at the Nevada Test Site (NTS) during the era of nuclear weapons testing provides much information on how underground military structures respond. Transferring this knowledge to answer questions about the urban civilian environment is needed to help plan responses to IND scenarios. Explosions just above the ground surface can only couple a small fraction of the blast energy into an underground shock. The various forms of nuclear radiation have limited penetration into the ground. While the shock transmitted into the ground carries only a small fraction of the blast energy, peak stresses are generally higher and peak ground displacement is lower than in the air blast. While underground military structures are often designed to resist stresses substantially higher than due to the overlying rocks and soils (overburden), civilian structures such as subways and tunnels would generally only need to resist overburden conditions with a suitable safety factor. Just as we expect the buildings themselves to channel and shield air blast above ground, basements and other underground openings as well as changes of geology will channel and shield the underground shock wave. While a weaker shock is expected in an urban environment, small displacements on very close-by faults, and more likely, soils being displaced past building foundations where utility lines enter could readily damaged or disable these services. Immediately near an explosion, the blast can 'liquefy' a saturated soil creating a quicksand-like condition for a period of time. We extrapolate the nuclear effects experience to a Chicago-based scenario. We consider the TARP (Tunnel and Reservoir Project) and subway system and the underground lifeline (electric, gas, water, etc) system and provide guidance for planning this scenario.

  1. Inventories and scenarios of nitrous oxide emissions

    NASA Astrophysics Data System (ADS)

    Davidson, Eric A.; Kanter, David

    2014-10-01

    Effective mitigation for N2O emissions, now the third most important anthropogenic greenhouse gas and the largest remaining anthropogenic source of stratospheric ozone depleting substances, requires understanding of the sources and how they may increase this century. Here we update estimates and their uncertainties for current anthropogenic and natural N2O emissions and for emissions scenarios to 2050. Although major uncertainties remain, ‘bottom-up’ inventories and ‘top-down’ atmospheric modeling yield estimates that are in broad agreement. Global natural N2O emissions are most likely between 10 and 12 Tg N2O-N yr-1. Net anthropogenic N2O emissions are now about 5.3 Tg N2O-N yr-1. Gross anthropogenic emissions by sector are 66% from agriculture, 15% from energy and transport sectors, 11% from biomass burning, and 8% from other sources. A decrease in natural emissions from tropical soils due to deforestation reduces gross anthropogenic emissions by about 14%. Business-as-usual emission scenarios project almost a doubling of anthropogenic N2O emissions by 2050. In contrast, concerted mitigation scenarios project an average decline of 22% relative to 2005, which would lead to a near stabilization of atmospheric concentration of N2O at about 350 ppb. The impact of growing demand for biofuels on future projections of N2O emissions is highly uncertain; N2O emissions from second and third generation biofuels could remain trivial or could become the most significant source to date. It will not be possible to completely eliminate anthropogenic N2O emissions from agriculture, but better matching of crop N needs and N supply offers significant opportunities for emission reductions.

  2. Automated Scenario Generation and Interaction Techniques

    DTIC Science & Technology

    1981-06-01

    LEVEIt2 RADC-TR4. 1 - 1 1 Phwl Technical Report Jun. 1981 4 ": AUTOMATED SCENARIO GENERATION AND INTERACTION TECHNIQUES Martin Marietto Aerospace...SECURITY CLASSIFICATION OF THIS PAGE (When Date Rnterod) TABLE OF CONTENTS 1.0 INTRODUCTION 1 2.0 OBJECTIVES 2 3.0 APPROACH 2 4.0 INTERVIEW RESULTS 3 5.0...method 4> are: ( 1 ) the ability to analyze a player’s response to a given situation at the time that the situation arises; (2) to allow each player to

  3. Postulated accident scenarios in weapons disassembly

    SciTech Connect

    Payne, S.S.

    1997-06-01

    A very brief summary of three postulated accident scenarios for weapons disassembly is provided in the paper. The first deals with a tetrahedral configuration of four generic pits; the second, an infinite planar array of generic pits with varying interstitial water density; and the third, a spherical shell with internal mass suspension in water varying the size and mass of the shell. Calculations were performed using the Monte Carlo Neutron Photon transport code MCNP4A. Preliminary calculations pointed to a need for higher resolution of small pit separation regimes and snapshots of hydrodynamic processes of water/plutonium mixtures.

  4. Braneworld Scenarios from Deformed Defect Chains

    NASA Astrophysics Data System (ADS)

    Chinaglia, M.; Bernardini, A. E.; da Rocha, Roldão

    2016-10-01

    Novel braneworld scenarios supported by warp factors driven by a single extra dimension are obtained from deformed one-dimensional lump-like solutions known a priori. Through a novel ansatz, the internal energy structure, the braneworld warp factor, and the quantum mechanical analogue problem, as well as the associated zero mode solutions, are straightforwardly derived by means of an analytical procedure. The results allow one to identify thick brane solutions that support internal structures and that can hold the (3+1)-dimensional gravity.

  5. 2015 Standard Scenarios Annual Report: U.S. Electric Sector Scenario Exploration

    SciTech Connect

    Sullivan, Patrick; Cole, Wesley; Blair, Nate; Lantz, Eric; Krishnan, Venkat; Mai, Trieu; Mulcahy, David; Porro, Gian

    2015-07-16

    This report is one of several products resulting from an initial effort to provide a consistent set of technology cost and performance data and to define a conceptual and consistent scenario framework that can be used in the National Renewable Energy Laboratory’s (NREL’s) future analyses. The long-term objective of this effort is to identify a range of possible futures of the U.S. electricity sector in which to consider specific energy system issues through (1) defining a set of prospective scenarios that bound ranges of key technology, market, and policy assumptions and (2) assessing these scenarios in NREL’s market models to understand the range of resulting outcomes, including energy technology deployment and production, energy prices, and carbon dioxide (CO2) emissions.

  6. Sociotechnical scenarios for the Austrian energy system

    NASA Astrophysics Data System (ADS)

    Ornetzeder, Michael; Rohracher, Harald; Wächter, Petra

    2012-10-01

    Reducing greenhouse gases by 80%, as demanded by the IPCC, is one of the great long-term challenges facing our societies today and will doubtless require transformative changes to current energy regimes. Large-scale system transitions such as the one envisaged for the global energy system in the next 30-40 years can only be realized through complex processes of change involving global, regional, national, and local levels. In this paper we use sociotechnical scenario analysis to contribute ideas for the transformative change of the current Austrian energy system over the long term and to identify some of the particular policy measures, as well as structural changes and broader shifts in perspective, that would be necessary to deal with such challenges. There is less emphasis on the technical issues involved than on the socio-economic and governance requirements such a shift would demand. We also explain our experiences with the sociotechnical scenario process and its outcomes. In particular, we identify examples of some critical issues and opportunities within one of the identified key action fields and discuss their various implications for energy policy and everyday practices.

  7. Haunted Quantum Entanglement: A New Scenario

    NASA Astrophysics Data System (ADS)

    Snyder, Douglas

    2010-10-01

    A haunted quantum entanglement scenario is proposed that is very close to Greenberger and YaSin's haunted measurement in that: 1) the entity that is developing as a which-way marker is effectively restored to its state prior to its developing as a which-way marker, and 2) the entity for which the developing which-way marker provides information enters the state it would have had if the development of the which-way marker had never begun. In the hqe scenario, the loss of developing which-way information through 1 relies on the loss of a developing entanglement. The photon initially emitted in one of two micromaser cavities and developing into a which-way marker is effectively lost through the injection of classical microwave radiation into both of the microwave cavities: 1) after the atom initially emits the photon into one of the micromaser cavities and exits the cavity system, and 2) before this atom reaches the 2 slit screen. The atom enters the state it would have had if the atom had never emitted the photon into one of the micromaser cavities because of the injection of classical microwave radiation into both of the microwave cavities and the presence of an rf coil situated at the exit of the micromaser cavity system.

  8. Mars Sample Return mission: Two alternate scenarios

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Two scenarios for accomplishing a Mars Sample Return mission are presented herein. Mission A is a low cost, low mass scenario, while Mission B is a high technology, high science alternative. Mission A begins with the launch of one Titan IV rocket with a Centaur G' upper stage. The Centaur performs the trans-Mars injection burn and is then released. The payload consists of two lander packages and the Orbital Transfer Vehicle, which is responsible for supporting the landers during launch and interplanetary cruise. After descending to the surface, the landers deploy small, local rovers to collect samples. Mission B starts with 4 Titan IV launches, used to place the parts of the Planetary Transfer Vehicle (PTV) into orbit. The fourth launch payload is able to move to assemble the entire vehicle by simple docking routines. Once complete, the PTV begins a low thrust trajectory out from low Earth orbit, through interplanetary space, and into low Martian orbit. It deploys a communication satellite into a 1/2 sol orbit and then releases the lander package at 500 km altitude. The lander package contains the lander, the Mars Ascent Vehicle (MAV), two lighter than air rovers (called Aereons), and one conventional land rover. The entire package is contained with a biconic aeroshell. After release from the PTV, the lander package descends to the surface, where all three rovers are released to collect samples and map the terrain.

  9. Revised scenario for human missions to Mars

    NASA Astrophysics Data System (ADS)

    Salotti, Jean Marc

    2012-12-01

    We present a revised version of our scenario for human missions to Mars. The idea is to take into consideration the difficulties and constraints for entry, descent and landing by splitting the heavy vehicle into two smaller ones. The standard capsule shape is thus possible for aerocapture and landing on Mars. It is suggested to use the largest possible diameter such that the ballistic coefficient is minimized and the lift to drag ratio is kept small. The maneuvers for the descent and landing are then simplified and the risks are minimized. The scenario has been modified to cope with the new constraints. Different options have been taken into account. It is possible to land a small Mars ascent vehicle or to reuse the habitat lander for Mars ascent. All options perform as well as the others for the criterion of the initial mass in low Earth orbit. However, reusing the habitat lander allows a significant reduction of the size of the Earth return vehicle, which otherwise requires a huge launching capability.

  10. Biomass Scenario Model Documentation: Data and References

    SciTech Connect

    Lin, Y.; Newes, E.; Bush, B.; Peterson, S.; Stright, D.

    2013-05-01

    The Biomass Scenario Model (BSM) is a system dynamics model that represents the entire biomass-to-biofuels supply chain, from feedstock to fuel use. The BSM is a complex model that has been used for extensive analyses; the model and its results can be better understood if input data used for initialization and calibration are well-characterized. It has been carefully validated and calibrated against the available data, with data gaps filled in using expert opinion and internally consistent assumed values. Most of the main data sources that feed into the model are recognized as baseline values by the industry. This report documents data sources and references in Version 2 of the BSM (BSM2), which only contains the ethanol pathway, although subsequent versions of the BSM contain multiple conversion pathways. The BSM2 contains over 12,000 total input values, with 506 distinct variables. Many of the variables are opportunities for the user to define scenarios, while others are simply used to initialize a stock, such as the initial number of biorefineries. However, around 35% of the distinct variables are defined by external sources, such as models or reports. The focus of this report is to provide insight into which sources are most influential in each area of the supply chain.

  11. Dark Matter searches: the nightmare scenario

    NASA Astrophysics Data System (ADS)

    Bertone, Gianfranco; Cumberbatch, Daniel; Ruiz de Austri, Roberto; Trotta, Roberto

    2012-01-01

    The unfortunate case where the Large Hadron Collider (LHC) fails to discover physics Beyond the Standard Model (BSM) is sometimes referred to as the ``Nightmare scenario'' of particle physics. We study the consequences of this hypothetical scenario for Dark Matter (DM), in the framework of the constrained Minimal Supersymmetric Standard Model (cMSSM). We evaluate the surviving regions of the cMSSM parameter space after null searches at the LHC, using several different LHC configurations, and study the consequences for DM searches with ton-scale direct detectors and the IceCube neutrino telescope. We demonstrate that ton-scale direct detection experiments will be able to conclusively probe the cMSSM parameter space that would survive null searches at the LHC with 100 fb-1 of integrated luminosity at 14 TeV. We also demonstrate that IceCube (80 strings plus DeepCore) will be able to probe as much as simeq 17% of the currently favoured parameter space after 5 years of observation.

  12. Dark Matter searches: the nightmare scenario

    SciTech Connect

    Bertone, Gianfranco; Cumberbatch, Daniel; Austri, Roberto Ruiz de

    2012-01-01

    The unfortunate case where the Large Hadron Collider (LHC) fails to discover physics Beyond the Standard Model (BSM) is sometimes referred to as the ''Nightmare scenario'' of particle physics. We study the consequences of this hypothetical scenario for Dark Matter (DM), in the framework of the constrained Minimal Supersymmetric Standard Model (cMSSM). We evaluate the surviving regions of the cMSSM parameter space after null searches at the LHC, using several different LHC configurations, and study the consequences for DM searches with ton-scale direct detectors and the IceCube neutrino telescope. We demonstrate that ton-scale direct detection experiments will be able to conclusively probe the cMSSM parameter space that would survive null searches at the LHC with 100 fb{sup −1} of integrated luminosity at 14 TeV. We also demonstrate that IceCube (80 strings plus DeepCore) will be able to probe as much as ≅ 17% of the currently favoured parameter space after 5 years of observation.

  13. Beyond Inflation: A Cyclic Universe Scenario

    NASA Astrophysics Data System (ADS)

    Turok, Neil; Steinhardt, Paul J.

    2005-01-01

    Inflation has been the leading early universe scenario for two decades, and has become an accepted element of the successful `cosmic concordance' model. However, there are many puzzling features of the resulting theory. It requires both high energy and low energy inflation, with energy densities differing by a hundred orders of magnitude. The questions of why the universe started out undergoing high energy inflation, and why it will end up in low energy inflation, are unanswered. Rather than resort to anthropic arguments, we have developed an alternative cosmology, the cyclic universe, in which the universe exists in a very long-lived attractor state determined by the laws of physics. The model shares inflation's phenomenological successes without requiring an epoch of high energy inflation. Instead, the universe is made homogeneous and flat, and scale-invariant adiabatic perturbations are generated during an epoch of low energy acceleration like that seen today, but preceding the last big bang. Unlike inflation, the model requires low energy acceleration in order for a periodic attractor state to exist. The key challenge facing the scenario is that of passing through the cosmic singularity at t = 0. Substantial progress has been made at the level of linearised gravity, which is reviewed here. The challenge of extending this to nonlinear gravity and string theory remains.

  14. Beyond Inflation:. A Cyclic Universe Scenario

    NASA Astrophysics Data System (ADS)

    Turok, Neil; Steinhardt, Paul J.

    2005-08-01

    Inflation has been the leading early universe scenario for two decades, and has become an accepted element of the successful 'cosmic concordance' model. However, there are many puzzling features of the resulting theory. It requires both high energy and low energy inflation, with energy densities differing by a hundred orders of magnitude. The questions of why the universe started out undergoing high energy inflation, and why it will end up in low energy inflation, are unanswered. Rather than resort to anthropic arguments, we have developed an alternative cosmology, the cyclic universe [1], in which the universe exists in a very long-lived attractor state determined by the laws of physics. The model shares inflation's phenomenological successes without requiring an epoch of high energy inflation. Instead, the universe is made homogeneous and flat, and scale-invariant adiabatic perturbations are generated during an epoch of low energy acceleration like that seen today, but preceding the last big bang. Unlike inflation, the model requires low energy acceleration in order for a periodic attractor state to exist. The key challenge facing the scenario is that of passing through the cosmic singularity at t = 0. Substantial progress has been made at the level of linearised gravity, which is reviewed here. The challenge of extending this to nonlinear gravity and string theory remains.

  15. Emergent universe in the braneworld scenario

    NASA Astrophysics Data System (ADS)

    Heydarzade, Y.; Hadi, H.; Darabi, F.; Sheykhi, A.

    2016-06-01

    According to Padmanabhan's proposal, the difference between the surface degrees of freedom and the bulk degrees of freedom in a region of space may result in the acceleration of Universe expansion through the relation Δ V/Δ t = N_sur-N_bulk where N_bulk and N_sur are referred to the degrees of freedom related to the matter and energy content inside the bulk and surface area, respectively (Padmanabhan, arXiv:1206.4916v1, 2012). In this paper, we study the dynamical effect of the extrinsic geometrical embedding of an arbitrary four-dimensional brane in a higher-dimensional bulk space and investigate the corresponding degrees of freedom. Considering the modification of the Friedmann equations arising from a general braneworld scenario, we obtain a correction term in Padmanabhan's relation, denoting the number of degrees of freedom related to the extrinsic geometry of the brane embedded in higher-dimensional spacetime as Δ V /Δ t=N_sur-N_bulk-N_extr where N_extr is for the degree of freedom related to the extrinsic geometry of the brane, while N_sur and N_bulk are defined as before. Finally, we study the validity of the first and second laws of thermodynamics for this general braneworld scenario in the state of thermal equilibrium and in the presence of confined matter fields to the brane with the induced geometric matter fields.

  16. FORMAL SCENARIO DEVELOPMENT FOR ENVIRONMENTAL IMPACT ASSESSMENT STUDIES

    EPA Science Inventory

    Scenario analysis is a process of evaluating possible future events through the consideration of alternative plausible (though not equally likely) outcomes (scenarios). The analysis is designed to enable improved decision-making and assessment through a more rigorous evaluation o...

  17. An Experiment on Graph Analysis Methodologies for Scenarios

    SciTech Connect

    Brothers, Alan J.; Whitney, Paul D.; Wolf, Katherine E.; Kuchar, Olga A.; Chin, George

    2005-09-30

    Visual graph representations are increasingly used to represent, display, and explore scenarios and the structure of organizations. The graph representations of scenarios are readily understood, and commercial software is available to create and manage these representations. The purpose of the research presented in this paper is to explore whether these graph representations support quantitative assessments of the underlying scenarios. The underlying structure of the scenarios is the information that is being targeted in the experiment and the extent to which the scenarios are similar in content. An experiment was designed that incorporated both the contents of the scenarios and analysts’ graph representations of the scenarios. The scenarios’ content was represented graphically by analysts, and both the structure and the semantics of the graph representation were attempted to be used to understand the content. The structure information was not found to be discriminating for the content of the scenarios in this experiment; but, the semantic information was discriminating.

  18. Integrating Future Information through Scenarios. AIR 1985 Annual Forum Paper.

    ERIC Educational Resources Information Center

    Zentner, Rene D.

    The way that higher education planners can take into account changes in the post-industrial society is discussed. The scenario method is proposed as a method of integrating futures information. The planner can be provided with several probable futures, each of which can be incorporated in a scenario. An effective scenario provides the planner…

  19. Effects of Scenario Planning on Participant Mental Models

    ERIC Educational Resources Information Center

    Glick, Margaret B.; Chermack, Thomas J.; Luckel, Henry; Gauck, Brian Q.

    2012-01-01

    Purpose: The purpose of this paper is to assess the effects of scenario planning on participant mental model styles. Design/methodology/approach: The scenario planning literature is consistent with claims that scenario planning can change individual mental models. These claims are supported by anecdotal evidence and stories from the practical…

  20. 40 CFR 68.28 - Alternative release scenario analysis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 16 2013-07-01 2013-07-01 false Alternative release scenario analysis... scenario analysis. (a) The number of scenarios. The owner or operator shall identify and analyze at least... Consequence Analysis Guidance or any commercially or publicly available air dispersion modeling...

  1. Advanced tokamak scenario developments for the next step

    NASA Astrophysics Data System (ADS)

    Joffrin, E.

    2007-12-01

    The objective of advanced tokamak scenario research is to provide a candidate plasma scenario for continuous operation in a fusion power plant. The optimization of the self-generated non-inductive current by the bootstrap mechanism up to a level of 50% and above using high plasma pressure and improved confinement are the necessary conditions to achieve this goal. The two main candidate scenarios for continuous operation, the steady state scenario and long duration (up to 3000 s) high neutron fluency scenario (the hybrid scenario), both face physics challenges in terms of confinement, stability, power exhaust and plasma control. Resistive wall modes and Alfvénic fast ion driven instabilities are the main limitations for operating the steady state scenario at high pressure and low magnetic shear. In addition, this scenario demands a high degree of control over the plasma current and pressure profile and the steady state heat load on in-vessel plasma facing components. Understanding the confinement properties of hybrid scenario is still an outstanding issue as well as its modelling for ITER in particular with regard to the H-mode pedestal parameters. This scenario will also require active current profile control, although, less demanding than for the steady state scenario. To operate advanced tokamak scenario, broad current and pressure profile control appears as a necessary requirement on ITER actuators, in addition to the tools required for instability control such as error field coils or electron cyclotron current drive.

  2. Various problems in lunar habitat construction scenarios

    NASA Astrophysics Data System (ADS)

    Nitta, Keiji; Ohtsubo, Koji; Oguchi, Mitsuo; Ohya, Haruhiko; Kanbe, Seiichiro; Ashida, Akira; Sano, Kenichi

    1991-10-01

    Many papers describing the lunar base construction have been published previously. Lunar base has been considered to be a useful facility to conduct future scientific programs and to get new nuclear energy resource, namely 3He, for defending the environmental collapse on Earth and also to develop lunar resources such as oxygen and nitrogen for extending human activities in space more economically. The scale of the lunar base and the construction methods adopted are determined by the scenario of a lunar utilization program but constrained by the availability of the established space transportation technologies. As indicated in the scenarios described in papers regarding lunar base construction, the first steps of lunar missions are the investigation of lunar itself for conducting scientific research and for surveying the lunar base construction sites, the second steps are the outpost construction for conducting man-tended missions, for more precise scientific research and studying the lunar base construction methods, and third steps are the construction of a permanent base and the expansion of this lunar base for exploiting lunar resources. The missions within the first and second steps are all possible using the ferry (OTV) similar to the service and command modules of Apollo Spacecraft because all necessary weights to be landed on the lunar surface for these missions seem to be under the equivalent weight of the Apollo Lunar Lander. On the other hand, the permanent facilities constructed on the lunar surface in the third step requires larger quantities of construction materials to be transported from Earth, and a new ferry (advanced OTV) having higher transportation ability, at least above 6 times, compared with Apollo Service and Command Modules, are to be developed. The largest problems in the permament lunar base construction are related to the food production facilities, 30-40 m 2 plant cultivation area per person are required for providing the nutrition

  3. Adaptive memory: the survival scenario enhances item-specific processing relative to a moving scenario.

    PubMed

    Burns, Daniel J; Hart, Joshua; Griffith, Samantha E; Burns, Amy D

    2013-01-01

    Nairne, Thompson, and Pandeirada (2007) found that retention of words rated for their relevance to survival is superior to that of words encoded under numerous other deep processing conditions. They suggested that our memory systems might have evolved to confer an advantage for survival-relevant information. Burns, Burns, and Hwang (2011) suggested a two-process explanation of the proximate mechanisms responsible for the survival advantage. Whereas most control tasks encourage only one type of processing, the survival task encourages both item-specific and relational processing. They found that when control tasks encouraged both types of processing, the survival processing advantage was eliminated. However, none of their control conditions included non-survival scenarios (e.g., moving, vacation, etc.), so it is not clear how this two-process explanation would explain the survival advantage when scenarios are used as control conditions. The present experiments replicated the finding that the survival scenario improves recall relative to a moving scenario in both a between-lists and within-list design and also provided evidence that this difference was accompanied by an item-specific processing difference, not a difference in relational processing. The implications of these results for several existing accounts of the survival processing effect are discussed.

  4. Judgments of culpability in a filicide scenario.

    PubMed

    Ferguson, Christopher J; Miller-Stratton, Heather; Heinrich, Emily; Fritz, Stacey; Smith, Shawn

    2008-01-01

    Previous research has indicated that potential jurors are likely to use personal biases, such as those based on gender and ethnicity, in their judgments of culpability of criminal defendants in addition to, or instead of, the facts of the crime. The present paper seeks to extend this literature to the crime of filicide; to examine whether male defendants are judged more harshly than female defendants, as is the case for domestic violence and sexual abuse. 214 participants were provided with a scenario of filicide in which the gender of the perpetrator, the gender of the child, and the family's social class were randomly assigned. Participants were asked to rate the culpability of the defendant in the case. Results indicated that, unlike for other violent crimes, participants did not use gender or social class biases in their judgments of criminal culpability.

  5. Future Scenarios for Mobile Science Learning

    NASA Astrophysics Data System (ADS)

    Burden, Kevin; Kearney, Matthew

    2016-04-01

    This paper adopts scenario planning as a methodological approach and tool to help science educators reconceptualise their use of mobile technologies across various different futures. These `futures' are set out neither as predictions nor prognoses but rather as stimuli to encourage greater discussion and reflection around the use of mobile technologies in science education. Informed by the literature and our empirical data, we consider four alternative futures for science education in a mobile world, with a particular focus on networked collaboration and student agency. We conclude that `seamless learning', whereby students are empowered to use their mobile technologies to negotiate across physical and virtual boundaries (e.g. between school and out-of-school activities), may be the most significant factor in encouraging educators to rethink their existing pedagogical patterns, thereby realizing some of the promises of contextualised participatory science learning.

  6. Multipartite maximally entangled states in symmetric scenarios

    NASA Astrophysics Data System (ADS)

    González-Guillén, Carlos E.

    2012-08-01

    We consider the class of (N+1)-partite states suitable for protocols where there is a powerful party, the authority, and the other N parties play the same role, namely, the state of their system lies in the symmetric Hilbert space. We show that, within this scenario, there is a “maximally entangled state” that can be transform by a local operations and classical communication protocol into any other state. In addition, we show how to use the protocol efficiently, including the construction of the state, and discuss security issues for possible applications to cryptographic protocols. As an immediate consequence we recover a sequential protocol that implements the 1-to-N symmetric cloning.

  7. Emergence in holographic scenarios for gravity

    NASA Astrophysics Data System (ADS)

    Dieks, Dennis; van Dongen, Jeroen; de Haro, Sebastian

    2015-11-01

    'Holographic' relations between theories have become an important theme in quantum gravity research. These relations entail that a theory without gravity is equivalent to a gravitational theory with an extra spatial dimension. The idea of holography was first proposed in 1993 by Gerard 't Hooft on the basis of his studies of evaporating black holes. Soon afterwards the holographic 'AdS/CFT' duality was introduced, which since has been intensively studied in the string theory community and beyond. Recently, Erik Verlinde has proposed that even Newton's law of gravitation can be related holographically to the 'thermodynamics of information' on screens. We discuss these scenarios, with special attention to the status of the holographic relation in them and to the question of whether they make gravity and spacetime emergent. We conclude that only Verlinde's scheme straightforwardly instantiates emergence. However, assuming a non-standard interpretation of AdS/CFT may create room for the emergence of spacetime and gravity there as well.

  8. A COLLISIONLESS SCENARIO FOR URANUS TILTING

    SciTech Connect

    Boue, Gwenael; Laskar, Jacques

    2010-03-20

    The origin of the high inclination of Uranus' spin-axis (Uranus' obliquity) is one of the great unanswered questions about the solar system. Giant planets are believed to form with nearly zero obliquity, and it has been shown that the present behavior of Uranus' spin is essentially stable. Several attempts were made in order to solve this problem. Here we report numerical simulations showing that Uranus' axis can be tilted during the planetary migration, without the need of a giant impact, provided that the planet had an additional satellite and a temporary large inclination. This might have happened during the giant planet instability phase described in the Nice model. In our scenario, the satellite is ejected after the tilt by a close encounter at the end of the migration. This model can both explain Uranus' large obliquity and bring new constraints on the planet orbital evolution.

  9. Sarin exposure: a simulation case scenario.

    PubMed

    Eason, Martin P

    2013-01-01

    Given the current geopolitical tensions, the risk of a terrorist attack on the United States is constant and increasing. Chemical terrorism, specifically the use of nerve agents, has occurred in other nations. Because of the ease of manufacture, the ability to conceal them, and the lethality of these agents, they pose a potential threat as a weapon of terror. Nerve agent exposure requires prompt recognition, a series of actions to mitigate further exposure to others, and management of the physiological sequelae of exposure. Many civilian healthcare providers are unprepared to manage injuries from nerve exposure. Failure to recognize the signs of nerve agent exposure will increase mortality and morbidity in victims and place healthcare providers at risk. Simulation is an effective methodology to train healthcare personnel in disaster preparedness. This article presents a simulation scenario that reviews the presentation of nerve agent exposure, its management, and a recipe for performing this simulation in a training exercise.

  10. The Asymptotic Safety Scenario in Quantum Gravity.

    PubMed

    Niedermaier, Max; Reuter, Martin

    2006-01-01

    The asymptotic safety scenario in quantum gravity is reviewed, according to which a renormalizable quantum theory of the gravitational field is feasible which reconciles asymptotically safe couplings with unitarity. The evidence from symmetry truncations and from the truncated flow of the effective average action is presented in detail. A dimensional reduction phenomenon for the residual interactions in the extreme ultraviolet links both results. For practical reasons the background effective action is used as the central object in the quantum theory. In terms of it criteria for a continuum limit are formulated and the notion of a background geometry self-consistently determined by the quantum dynamics is presented. Self-contained appendices provide prerequisites on the background effective action, the effective average action, and their respective renormalization flows.

  11. Overview of the Biomass Scenario Model

    SciTech Connect

    Peterson, Steve

    2015-09-01

    This report describes the structure of the October 2012 version of the Biomass Scenario Model (BSM) in considerable detail, oriented towards readers with a background or interest in the underlying modeling structures. Readers seeking a less-detailed summary of the BSM may refer to Peterson (2013). BSM aims to provide a framework for exploring the potential contribution of biofuel technologies to the transportation energy supply for the United States over the next several decades. The model has evolved significantly from the prototype developed as part of the Role of Biomass in America" tm s Energy Future (RBAEF) project. BSM represents the supply chain surrounding conversion pathways for multiple fuel products, including ethanol, butanol, and infrastructure-compatible biofuels such as diesel, jet fuel, and gasoline.

  12. Stochastic Optimization for Nuclear Facility Deployment Scenarios

    NASA Astrophysics Data System (ADS)

    Hays, Ross Daniel

    Single-use, low-enriched uranium oxide fuel, consumed through several cycles in a light-water reactor (LWR) before being disposed, has become the dominant source of commercial-scale nuclear electric generation in the United States and throughout the world. However, it is not without its drawbacks and is not the only potential nuclear fuel cycle available. Numerous alternative fuel cycles have been proposed at various times which, through the use of different reactor and recycling technologies, offer to counteract many of the perceived shortcomings with regards to waste management, resource utilization, and proliferation resistance. However, due to the varying maturity levels of these technologies, the complicated material flow feedback interactions their use would require, and the large capital investments in the current technology, one should not deploy these advanced designs without first investigating the potential costs and benefits of so doing. As the interactions among these systems can be complicated, and the ways in which they may be deployed are many, the application of automated numerical optimization to the simulation of the fuel cycle could potentially be of great benefit to researchers and interested policy planners. To investigate the potential of these methods, a computational program has been developed that applies a parallel, multi-objective simulated annealing algorithm to a computational optimization problem defined by a library of relevant objective functions applied to the Ver ifiable Fuel Cycle Simulati on Model (VISION, developed at the Idaho National Laboratory). The VISION model, when given a specified fuel cycle deployment scenario, computes the numbers and types of, and construction, operation, and utilization schedules for, the nuclear facilities required to meet a predetermined electric power demand function. Additionally, it calculates the location and composition of the nuclear fuels within the fuel cycle, from initial mining through

  13. Addressing an Uncertain Future Using Scenario Analysis

    SciTech Connect

    Siddiqui, Afzal S.; Marnay, Chris

    2006-12-15

    The Office of Energy Efficiency and Renewable Energy (EERE) has had a longstanding goal of introducing uncertainty into the analysis it routinely conducts in compliance with the Government Performance and Results Act (GPRA) and for strategic management purposes. The need to introduce some treatment of uncertainty arises both because it would be good general management practice, and because intuitively many of the technologies under development by EERE have a considerable advantage in an uncertain world. For example, an expected kWh output from a wind generator in a future year, which is not exposed to volatile and unpredictable fuel prices, should be truly worth more than an equivalent kWh from an alternative fossil fuel fired technology. Indeed, analysts have attempted to measure this value by comparing the prices observed in fixed-price natural gas contracts compared to ones in which buyers are exposed to market prices (see Bolinger, Wiser, and Golove and (2004)). In addition to the routine reasons for exploring uncertainty given above, the history of energy markets appears to have exhibited infrequent, but troubling, regime shifts, i.e., historic turning points at which the center of gravity or fundamental nature of the system appears to have abruptly shifted. Figure 1 below shows an estimate of how the history of natural gas fired generating costs has evolved over the last three decades. The costs shown incorporate both the well-head gas price and an estimate of how improving generation technology has gradually tended to lower costs. The purpose of this paper is to explore scenario analysis as a method for introducing uncertainty into EERE's forecasting in a manner consistent with the preceding observation. The two questions are how could it be done, and what is its academic basis, if any. Despite the interest in uncertainty methods, applying them poses some major hurdles because of the heavy reliance of EERE on forecasting tools that are deterministic in

  14. Neutralino dark matter from string scenarios

    SciTech Connect

    Cerdeno, D. G.

    2007-01-12

    The direct detection of neutralino dark matter is analysed within the context of orbifold scenarios from the heterotic superstring. In particular, the neutralino-proton cross section is computed and compared with the sensitivity of detectors, taking into account the most recent experimental and astrophysical constraints. In addition to the usual non-universalities of the soft terms in orbifold compactifications, due to their modular weight dependence, the contribution of a D-term, generated by the presence of an anomalous U(1) is also investigated. The D-term contribution provides more flexibility in the non-universalities, and is crucial iniding dangerous charge and colour-breaking minima. Thanks to it, large neutralino detection cross sections can be obtained in regions of the parameter space fulfilling all experimental and astrophysical constraints.

  15. Neutralino dark matter in orbifold scenarios

    SciTech Connect

    Cerdeno, D. G.

    2006-11-28

    The direct detection of neutralino dark matter is analysed within the context of orbifold scenarios from the heterotic superstring. In particular, the theoretical predictions for the neutralino-proton cross section are evaluated and compared with the sensitivity of detectors, taking into account the most recent experimental and astrophysical constraints. In addition to the usual non-universalities of the soft terms in orbifold compactifications, due to their modular weight dependence, the contribution of a D-term, generated by the presence o anomalous U (1) is also investigated. The D-term contribution provides more flexibility in the non-universalities, and is crucial in avoiding dangerous charge and colour-breaking minima. Large neutralino detection cross sections can be obtained in regions of the parameter space fulfilling all experimental and astrophysical constraints thanks to the inclusion of the D-term contribution.

  16. Detecting genuine multipartite entanglement in steering scenarios

    NASA Astrophysics Data System (ADS)

    Jebaratnam, C.

    2016-05-01

    Einstein-Podolsky-Rosen (EPR) steering is a form of quantum nonlocality which is intermediate between entanglement and Bell nonlocality. EPR steering is a resource for quantum key distribution that is device independent on only one side in that it certifies bipartite entanglement when one party's device is not characterized while the other party's device is fully characterized. In this work, we introduce two types of genuine tripartite EPR steering, and derive two steering inequalities to detect them. In a semi-device-independent scenario where only the dimensions of two parties are assumed, the correlations which violate one of these inequalities also certify genuine tripartite entanglement. It is known that Alice can demonstrate bipartite EPR steering to Bob if and only if her measurement settings are incompatible. We demonstrate that quantum correlations can also detect tripartite EPR steering from Alice to Bob and Charlie, even if Charlie's measurement settings are compatible.

  17. Rapid impactor sample return (RISR) mission scenario

    NASA Astrophysics Data System (ADS)

    Walker, James D.; Freitas, Christopher J.; Tapley, Mark B.

    2004-01-01

    Due to the long lead time and great expense of traditional sample return mission plans to Mars or other astronomical bodies, there is a need for a new and innovative way to return materials, potentially at a lower cost. The Rapid Impactor Sample Return (RISR) mission is one such proposal. The general mission scenario involves a single pass of Mars, a Martian moon or an asteroid at high speeds (7 km/s), with the sample return vehicle skimming just 1 or 2 m above a high point (such as a top ridge on Olympus Mons on Mars) and releasing an impactor. The impactor strikes the ground, throwing up debris. The debris with roughly the same forward velocity will be captured by the sample return vehicle and returned to Earth. There is no delay or orbit in the vicinity of Mars or the asteroid: RISR is a one-pass mission. This paper discusses some of the details of the proposal. Calculations are presented that address the question of how much material can be recovered with this technique. There are concerns about the effect of Mars tenuous atmosphere. However, it will be noted that such issues do not occur for RISR style missions to Phobos, Deimos, or asteroids and Near Earth Objects (NEOs). Recent test results in the missile defense community (IFTs 6-8 in 2001, 2002) have scored direct hits at better than 1 m accuracy with closing velocities of 7.6 km/s, giving the belief that accuracy and sensing issues are developed to a point that the RISR mission scenario is feasible.

  18. Lunar transportation scenarios utilising the Space Elevator.

    PubMed

    Engel, Kilian A

    2005-01-01

    The Space Elevator (SE) concept has begun to receive an increasing amount of attention within the space community over the past couple of years and is no longer widely dismissed as pure science fiction. In light of the renewed interest in a, possibly sustained, human presence on the Moon and the fact that transportation and logistics form the bottleneck of many conceivable lunar missions, it is interesting to investigate what role the SE could eventually play in implementing an efficient Earth to Moon transportation system. The elevator allows vehicles to ascend from Earth and be injected into a trans-lunar trajectory without the use of chemical thrusters, thus eliminating gravity loss, aerodynamic loss and the need of high thrust multistage launch systems. Such a system therefore promises substantial savings of propellant and structural mass and could greatly increase the efficiency of Earth to Moon transportation. This paper analyzes different elevator-based trans-lunar transportation scenarios and characterizes them in terms of a number of benchmark figures. The transportation scenarios include direct elevator-launched trans-lunar trajectories, elevator launched trajectories via L1 and L2, as well as launch from an Earth-based elevator and subsequent rendezvous with lunar elevators placed either on the near or on the far side of the Moon. The benchmark figures by which the different transfer options are characterized and evaluated include release radius (RR), required delta v, transfer times as well as other factors such as accessibility of different lunar latitudes, frequency of launch opportunities and mission complexity. The performances of the different lunar transfer options are compared with each other as well as with the performance of conventional mission concepts, represented by Apollo.

  19. RMP Guidance for Chemical Distributors - Chapter 4: Offsite Consequence Analysis

    EPA Pesticide Factsheets

    How to perform the OCA for regulated substances, informing the government and the public about potential consequences of an accidental chemical release at your facility. Includes calculations for worst-case scenario, alternative scenarios, and endpoints.

  20. RMP Guidance for Warehouses - Chapter 4: Offsite Consequence Analysis

    EPA Pesticide Factsheets

    Offsite consequence analysis (OCA) informs government and the public about potential consequences of an accidental toxic or flammable chemical release at your facility, and consists of a worst-case release scenario and alternative release scenarios.