Illumination-redistribution lenses for non-circular spots

NASA Astrophysics Data System (ADS)

Parkyn, William A.; Pelka, David G.

2005-08-01

The design of illumination lenses is far easier under the regime of the small-source approximation, whereby central rays are taken as representative of the entire source. This implies that the lens is much larger than the source's active emitter, and its entire interior surface is nowhere close to the source. Also, a given source luminance requires a minimum lens area to achieve the candlepower necessary for target illumination. We introduce two-surface aspheric lenses for specific illuminations tasks involving ceiling-mounted downlights, lenses that achieve uniform illuminance at the output aperture as well as at the target. This means that squared-off lenses will produce square spots. In particular, a semicircular lens and a vertical mirror will produce a semicircular spot suitable for gambling tables.

Image data compression having minimum perceptual error

NASA Technical Reports Server (NTRS)

Watson, Andrew B. (Inventor)

1995-01-01

A method for performing image compression that eliminates redundant and invisible image components is described. The image compression uses a Discrete Cosine Transform (DCT) and each DCT coefficient yielded by the transform is quantized by an entry in a quantization matrix which determines the perceived image quality and the bit rate of the image being compressed. The present invention adapts or customizes the quantization matrix to the image being compressed. The quantization matrix comprises visual masking by luminance and contrast techniques and by an error pooling technique all resulting in a minimum perceptual error for any given bit rate, or minimum bit rate for a given perceptual error.

Perceived area and the luminosity threshold.

PubMed

Bonato, F; Gilchrist, A L

1999-07-01

Observers made forced-choice opaque/luminous responses to targets of varying luminance and varying size presented (1) on the wall of a laboratory, (2) as a disk within an annulus, and (3) embedded within a Mondrian array presented within a vision tunnel. Lightness matches were also made for nearby opaque surfaces. The results show that the threshold luminance value at which a target begins to appear self-luminous increases with its size, defined as perceived size, not retinal size. More generally, the larger the target, the more an increase in its luminance induces grayness/blackness into the surround and the less it induces luminosity into the target, and vice versa. Corresponding to this luminosity/grayness tradeoff, there appears to be an invariant: Across a wide variety of conditions, a target begins to appear luminous when its luminance is about 1.7 times that of a surface that would appear white in the same illumination. These results show that the luminosity threshold behaves like a surface lightness value--the maximum lightness value, in fact--and is subject to the same laws of anchoring (such as the area rule proposed by Li & Gilchrist, 1999) as surface lightness.

The impact of the luminance, size and location of LED billboards on drivers' visual performance-Laboratory tests.

PubMed

Zalesinska, Malgorzata

2018-08-01

A proper visual performance by drivers can be ensured by, among else, a correct distribution of luminance in their field of view. At night, when the driver's sight is adapted to low luminance levels, high luminance level objects located near the road may be a source of glare, which is not only a nuisance, but it may also blind the driver. For many years, LED billboards (light-emitting diode billboards) have been installed near roads. Such billboards are usually large, have high luminance and show dynamically changing images. These parameters have a significant impact on the drivers' visual performance and, in turn, on road traffic safety. The study on the impact of the luminance, size and location of LED billboards on the drivers' visual performance was conducted on a volunteer group. Testing the impact of LED billboards on the visual performance of drivers in real-life conditions is very difficult. Therefore, the tests have been conducted in laboratory conditions, using a car driving simulator. The paper describes the testing procedure and tests results. The permissible luminance and areas of LED screens in two locations near the road, which significantly reduce the drivers' visual performance in municipal traffic at night, were determined by conducting an analysis of the results. Recommendations on the permissible luminance and areas of LED billboards were formulated. Copyright © 2018 Elsevier Ltd. All rights reserved.

Evaluation of color encodings for high dynamic range pixels

NASA Astrophysics Data System (ADS)

Boitard, Ronan; Mantiuk, Rafal K.; Pouli, Tania

2015-03-01

Traditional Low Dynamic Range (LDR) color spaces encode a small fraction of the visible color gamut, which does not encompass the range of colors produced on upcoming High Dynamic Range (HDR) displays. Future imaging systems will require encoding much wider color gamut and luminance range. Such wide color gamut can be represented using floating point HDR pixel values but those are inefficient to encode. They also lack perceptual uniformity of the luminance and color distribution, which is provided (in approximation) by most LDR color spaces. Therefore, there is a need to devise an efficient, perceptually uniform and integer valued representation for high dynamic range pixel values. In this paper we evaluate several methods for encoding colour HDR pixel values, in particular for use in image and video compression. Unlike other studies we test both luminance and color difference encoding in a rigorous 4AFC threshold experiments to determine the minimum bit-depth required. Results show that the Perceptual Quantizer (PQ) encoding provides the best perceptual uniformity in the considered luminance range, however the gain in bit-depth is rather modest. More significant difference can be observed between color difference encoding schemes, from which YDuDv encoding seems to be the most efficient.

33 CFR 84.15 - Intensity of lights.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Intensity of lights. 84.15... NAVIGATION RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.15 Intensity of lights. (a) The minimum luminous intensity of lights will be calculated by using the formula: I = 3.43 × 106...

33 CFR 84.15 - Intensity of lights.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Intensity of lights. 84.15... NAVIGATION RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.15 Intensity of lights. (a) The minimum luminous intensity of lights shall be calculated by using the formula: I=3.43×106×T...

33 CFR 84.15 - Intensity of lights.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Intensity of lights. 84.15... NAVIGATION RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.15 Intensity of lights. (a) The minimum luminous intensity of lights will be calculated by using the formula: I=3.43×106 ×T...

33 CFR 84.15 - Intensity of lights.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Intensity of lights. 84.15... NAVIGATION RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.15 Intensity of lights. (a) The minimum luminous intensity of lights will be calculated by using the formula: I=3.43×106 ×T...

33 CFR 84.15 - Intensity of lights.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Intensity of lights. 84.15... NAVIGATION RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.15 Intensity of lights. (a) The minimum luminous intensity of lights shall be calculated by using the formula: I=3.43×106×T...

Adaptive enhancement for nonuniform illumination images via nonlinear mapping

NASA Astrophysics Data System (ADS)

Wang, Yanfang; Huang, Qian; Hu, Jing

2017-09-01

Nonuniform illumination images suffer from degenerated details because of underexposure, overexposure, or a combination of both. To improve the visual quality of color images, underexposure regions should be lightened, whereas overexposure areas need to be dimmed properly. However, discriminating between underexposure and overexposure is troublesome. Compared with traditional methods that produce a fixed demarcation value throughout an image, the proposed demarcation changes as local luminance varies, thus is suitable for manipulating complicated illumination. Based on this locally adaptive demarcation, a nonlinear modification is applied to image luminance. Further, with the modified luminance, we propose a nonlinear process to reconstruct a luminance-enhanced color image. For every pixel, this nonlinear process takes the luminance change and the original chromaticity into account, thus trying to avoid exaggerated colors at dark areas and depressed colors at highly bright regions. Finally, to improve image contrast, a local and image-dependent exponential technique is designed and applied to the RGB channels of the obtained color image. Experimental results demonstrate that our method produces good contrast and vivid color for both nonuniform illumination images and images with normal illumination.

WE-D-204-03: A Six-Year Longitudinal Evaluation of the DICOM GSDF Conformance Stability of LCD Monitors

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKenney, S; Bevins, N; Flynn, M

2015-06-15

Purpose: The calibration of monitors in radiology is critical to ensure a standardized reading environment. If left unchecked, monitors initially calibrated to follow the DICOM Grayscale Standard Display Function (GSDF) can fall out of calibration. This work presents a quantitative evaluation of the stability of a cohort of monitors with similar deployment times and clinical utilization. Methods: Fifty-four liquid crystal display (LCD) monitors (NEC L200ME) were deployed for clinical use in 2009. At that time, a subset of eight of these monitors were used to generate a look-up table (LUT) using the open-source software pacsDisplay. The software was used tomore » load the LUT to the graphics card of the computer in order to make the monitors compliant with the GSDF. The luminance response of the monitors was evaluated twice over six years, once in 2011 and again in 2015. Results: As expected, the maximum luminance of the monitors decreased over time, with an average reduction from 2009 of 35% in 2011, and 53% in 2015. The luminance ratio (maximum luminance divided by the minimum) also decreased, with the all of the decrease occurring in the first two years (average 20%). There was an overall increase in relative error compared with the DICOM GSDF from measurement to measurement, indicating that deviation from the GSDF increases with monitor luminance reduction. Along with changes in luminance, several other issues were identified during the testing, including non-uniformities, bad pixels, and missing calibration software. Conclusion: From the initial installation of these monitors, most of the degradation occurred during the first two years, highlighting the importance of routine clinical testing of displays. Following such quality assurance, displays could be either re-calibrated or replaced depending on different thresholds. In addition, other issues not related to luminance could be identified and corrected.« less

Effect of stimulus size and luminance on the rod-, cone-, and melanopsin-mediated pupillary light reflex

PubMed Central

Park, Jason C.; McAnany, J. Jason

2015-01-01

This study determined if the pupillary light reflex (PLR) driven by brief stimulus presentations can be accounted for by the product of stimulus luminance and area (i.e., corneal flux density, CFD) under conditions biased toward the rod, cone, and melanopsin pathways. Five visually normal subjects participated in the study. Stimuli consisted of 1-s short- and long-wavelength flashes that spanned a large range of luminance and angular subtense. The stimuli were presented in the central visual field in the dark (rod and melanopsin conditions) and against a rod-suppressing short-wavelength background (cone condition). Rod- and cone-mediated PLRs were measured at the maximum constriction after stimulus onset whereas the melanopsin-mediated PLR was measured 5–7 s after stimulus offset. The rod- and melanopsin-mediated PLRs were well accounted for by CFD, such that doubling the stimulus luminance had the same effect on the PLR as doubling the stimulus area. Melanopsin-mediated PLRs were elicited only by short-wavelength, large (>16°) stimuli with luminance greater than 10 cd/m2, but when present, the melanopsin-mediated PLR was well accounted for by CFD. In contrast, CFD could not account for the cone-mediated PLR because the PLR was approximately independent of stimulus size but strongly dependent on stimulus luminance. These findings highlight important differences in how stimulus luminance and size combine to govern the PLR elicited by brief flashes under rod-, cone-, and melanopsin-mediated conditions. PMID:25788707

Preference limits of the visual dynamic range for ultra high quality and aesthetic conveyance

NASA Astrophysics Data System (ADS)

Daly, Scott; Kunkel, Timo; Sun, Xing; Farrell, Suzanne; Crum, Poppy

2013-03-01

A subjective study was conducted to investigate the preferred maximum and minimum display luminances in order to determine the dynamic ranges for future displays. Two studies address the diffuse reflective regions, and a third study tested preferences of highlight regions. Preferences, as opposed to detection thresholds, were studied to provide results more directly relevant to the viewing of entertainment or art. Test images were specifically designed to test these limits without the perceptual conflicts that usually occur in these types of studies. For the diffuse range, we found a display with a dynamic range having luminances between 0.1 and 650 cd/m2 matches the average preferences. However, to satisfy 90% of the population, a dynamic range from 0.005 and ~3,000 cd/m2 is needed. Since a display should be able to produce values brighter than the diffuse white maximum, as in specular highlights and emissive sources, the highlight study concludes that even the average preferred maximum luminance for highlight reproduction is ~4,000 cd/m2.

Continuous hierarchical slope-aspect color display for parametric surfaces

NASA Technical Reports Server (NTRS)

Moellering, Harold J. (Inventor); Kimerling, A. Jon (Inventor)

1994-01-01

A method for generating an image of a parametric surface, such as the aspect of terrain which maximizes color contrast to permit easy discrimination of the magnitude, ranges, intervals or classes of a surface parameter while making it easy for the user to visualize the form of the surface, such as a landscape. The four pole colors of the opponent process color theory are utilized to represent intervals or classes at 90 degree angles. The color perceived as having maximum measured luminance is selected to portray the color having an azimuth of an assumed light source and the color showing minimum measured luminance portrays the diametrically opposite azimuth. The 90 degree intermediate azimuths are portrayed by unique colors of intermediate measured luminance, such as red and green. Colors between these four pole colors are used which are perceived as mixtures or combinations of their bounding colors and are arranged progressively between their bounding colors to have perceived proportional mixtures of the bounding colors which are proportional to the interval's angular distance from its bounding colors.

Luminous Efficiency of Hypervelocity Meteoroid Impacts on the Moon Derived from the 2015 Geminid Meteor Shower

NASA Technical Reports Server (NTRS)

Moser, D. E.; Suggs, R. M.; Ehlert, S. R.

2017-01-01

Meteoroids cannot be observed directly because of their small size. In-situ measurements of the meteoroid environment are rare and have very small collecting areas. The Moon, in contrast, has a large collecting area and therefore can be used as a large meteoroid detector for gram-kilogram sized particles. Meteoroids striking the Moon create an impact flash observable by Earth-based telescopes. Their kinetic energy is converted to luminous energy with some unknown luminous efficiency ?(v), which is likely a function of meteoroid velocity (among other factors). This luminous efficiency is imperative to calculating the kinetic energy and mass of the meteoroid, as well as meteoroid fluxes, and it cannot be determined in the laboratory at meteoroid speeds and sizes due to mechanical constraints. Since laboratory simulations fail to resolve the luminous efficiency problem, observations of the impact flash itself must be utilized. Meteoroids associated with specific meteor showers have known speed and direction, which simplifies the determination of the luminous efficiency. NASA has routinely monitored the Moon for impact flashes since early 2006 [1]. During this time, several meteor showers have produced multiple impact flashes on the Moon, yielding a sufficient sample of impact flashes with which to perform a luminous efficiency analysis similar to that outlined in Bellot Rubio et al. [2, 3] and further described by Moser et al. [4], utilizing Earth-based measurements of the shower flux and mass index. The Geminid meteor shower has produced the most impact flashes in the NASA dataset to date with over 80 detections. More than half of these Geminids were recorded in 2015 (locations pictured in Fig. 1), and may represent the largest single-shower impact flash sample known. This work analyzes the 2015 Geminid lunar impacts and calculates their luminous efficiency. The luminous efficiency is then applied to calculate the kinetic energies and mass-es of these shower meteoroids.

Effect of contiguity and figure-ground organization on the area rule of lightness.

PubMed

Boyaci, Huseyin; Simşek, Mahru Kobal; Subaşı, Ece

2014-11-25

In a simple two-dimensional (2D) display composed of two uniform surfaces with different luminances, the lightness of the darker surface varies as a function of its relative area while its luminance is held constant (Gilchrist & Radonjić, 2009; Li & Gilchrist, 1999). This phenomenon is known as the area rule of lightness, and although it is extensively studied in the literature, the underlying principles are still largely unknown. Here, using computer-generated stimuli, we investigated the effects of contiguity and figure-ground organization on the area rule of lightness. Stimuli were 2D disks composed of radial sectors with high (25 cd/m2) or low (8 cd/m2) luminance. On each trial, observers judged the lightness of the sectors by adjusting the luminance of a matching patch. Four conditions were tested. In the contiguous condition, there were one dark and one light sector; in the noncontiguous condition, both the light and dark surfaces were split into four equal radial sectors. Figure and ground conditions were generated by adding small contextual elements to the stimulus. We found that the area rule applied under all conditions; however, the functional form of the effect showed marked differences across conditions. Taken together, our results show that both high-level (e.g., perceptual grouping, figure-ground organization) and low-level (e.g., spatial-summation) mechanisms play a role in the area rule of lightness. © 2014 ARVO.

A detail-preserved and luminance-consistent multi-exposure image fusion algorithm

NASA Astrophysics Data System (ADS)

Wang, Guanquan; Zhou, Yue

2018-04-01

When irradiance across a scene varies greatly, we can hardly get an image of the scene without over- or underexposure area, because of the constraints of cameras. Multi-exposure image fusion (MEF) is an effective method to deal with this problem by fusing multi-exposure images of a static scene. A novel MEF method is described in this paper. In the proposed algorithm, coarser-scale luminance consistency is preserved by contribution adjustment using the luminance information between blocks; detail-preserved smoothing filter can stitch blocks smoothly without losing details. Experiment results show that the proposed method performs well in preserving luminance consistency and details.

Image-adapted visually weighted quantization matrices for digital image compression

NASA Technical Reports Server (NTRS)

Watson, Andrew B. (Inventor)

1994-01-01

A method for performing image compression that eliminates redundant and invisible image components is presented. The image compression uses a Discrete Cosine Transform (DCT) and each DCT coefficient yielded by the transform is quantized by an entry in a quantization matrix which determines the perceived image quality and the bit rate of the image being compressed. The present invention adapts or customizes the quantization matrix to the image being compressed. The quantization matrix comprises visual masking by luminance and contrast techniques and by an error pooling technique all resulting in a minimum perceptual error for any given bit rate, or minimum bit rate for a given perceptual error.

Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells

NASA Technical Reports Server (NTRS)

Boyd, Nolan L.; Park, Heonyong; Yi, Hong; Boo, Yong Chool; Sorescu, George P.; Sykes, Michelle; Jo, Hanjoong

2003-01-01

Caveolae are plasmalemmal domains enriched with cholesterol, caveolins, and signaling molecules. Endothelial cells in vivo are continuously exposed to shear conditions, and their caveolae density and location may be different from that of static cultured cells. Here, we show that chronic shear exposure regulates formation and localization of caveolae and caveolin-1 in bovine aortic endothelial cells (BAEC). Chronic exposure (1 or 3 days) of BAEC to laminar shear increased the total number of caveolae by 45-48% above static control. This increase was due to a rise in the luminal caveolae density without changing abluminal caveolae numbers or increasing caveolin-1 mRNA and protein levels. Whereas some caveolin-1 was found in the plasma membrane in static-cultured cells, it was predominantly localized in the Golgi. In contrast, chronic shear-exposed cells showed intense caveolin-1 staining in the luminal plasma membrane with minimum Golgi association. The preferential luminal localization of caveolae may play an important role in endothelial mechanosensing. Indeed, we found that chronic shear exposure (preconditioning) altered activation patterns of two well-known shear-sensitive signaling molecules (ERK and Akt) in response to a step increase in shear stress. ERK activation was blunted in shear preconditioned cells, whereas the Akt response was accelerated. These results suggest that chronic shear stimulates caveolae formation by translocating caveolin-1 from the Golgi to the luminal plasma membrane and alters cell signaling responses.

Tube Law of the Pharyngeal Airway in Sleeping Patients with Obstructive Sleep Apnea.

PubMed

Genta, Pedro R; Edwards, Bradley A; Sands, Scott A; Owens, Robert L; Butler, James P; Loring, Stephen H; White, David P; Wellman, Andrew

2016-02-01

Obstructive sleep apnea (OSA) is characterized by repetitive pharyngeal collapse during sleep. However, the dynamics of pharyngeal narrowing and re-expansion during flow-limited breathing are not well described. The static pharyngeal tube law (end-expiratory area versus luminal pressure) has demonstrated increasing pharyngeal compliance as luminal pressure decreases, indicating that the airway would be sucked closed with sufficient inspiratory effort. On the contrary, the airway is rarely sucked closed during inspiratory flow limitation, suggesting that the airway is getting stiffer. Therefore, we hypothesized that during inspiratory flow limitation, as opposed to static conditions, the pharynx becomes stiffer as luminal pressure decreases. Upper airway endoscopy and simultaneous measurements of airflow and epiglottic pressure were performed during natural nonrapid eye movement sleep. Continuous positive (or negative) airway pressure was used to induce flow limitation. Flow-limited breaths were selected for airway cross-sectional area measurements. Relative airway area was quantified as a percentage of end-expiratory area. Inspiratory airway radial compliance was calculated at each quintile of epiglottic pressure versus airway area plot (tube law). Eighteen subjects (14 males) with OSA (apnea-hypopnea index = 57 ± 27 events/h), aged 49 ± 8 y, with a body mass index of 35 ± 6 kg/m(2) were studied. A total of 163 flow limited breaths were analyzed (9 ± 3 breaths per subject). Compliances at the fourth (2.0 ± 4.7 % area/cmH2O) and fifth (0.0 ± 1.7 % area/cmH2O) quintiles were significantly lower than the first (12.2 ± 5.5 % area/cmH2O) pressure quintile (P < 0.05). The pharyngeal tube law is concave (airway gets stiffer as luminal pressure decreases) during respiratory cycles under inspiratory flow limitation. © 2016 Associated Professional Sleep Societies, LLC.

Contour junctions defined by dynamic image deformations enhance perceptual transparency.

PubMed

Kawabe, Takahiro; Nishida, Shin'ya

2017-11-01

The majority of work on the perception of transparency has focused on static images with luminance-defined contour junctions, but recent work has shown that dynamic image sequences with dynamic image deformations also provide information about transparency. The present study demonstrates that when part of a static image is dynamically deformed, contour junctions at which deforming and nondeforming contours are connected facilitate the deformation-based perception of a transparent layer. We found that the impression of a transparent layer was stronger when a dynamically deforming area was adjacent to static nondeforming areas than when presented alone. When contour junctions were not formed at the dynamic-static boundaries, however, the impression of a transparent layer was not facilitated by the presence of static surrounding areas. The effect of the deformation-defined junctions was attenuated when the spatial pattern of luminance contrast at the junctions was inconsistent with the perceived transparency related to luminance contrast, while the effect did not change when the spatial luminance pattern was consistent with it. In addition, the results showed that contour completions across the junctions were required for the perception of a transparent layer. These results indicate that deformation-defined junctions that involve contour completion between deforming and nondeforming regions enhance the perception of a transparent layer, and that the deformation-based perceptual transparency can be promoted by the simultaneous presence of appropriately configured luminance and contrast-other features that can also by themselves produce the sensation of perceiving transparency.

Luminous electrical phenomena in Huntsville, Alabama, tornadoes on April 3, 1974

NASA Technical Reports Server (NTRS)

Vaughan, O. H., Jr.; Vonnegut, B.

1976-01-01

Unusual lightning and varicolored luminous phenomena were observed on the evening of April 3, 1974, when severe tornadoes passed through Madison County, Alabama. Photographs and eyewitness accounts of this electrical activity are related to the trajectories of the tornadoes and the damage areas they produced.

Mixing of Chromatic and Luminance Retinal Signals in Primate Area V1

PubMed Central

Li, Xiaobing; Chen, Yao; Lashgari, Reza; Bereshpolova, Yulia; Swadlow, Harvey A.; Lee, Barry B.; Alonso, Jose Manuel

2015-01-01

Vision emerges from activation of chromatic and achromatic retinal channels whose interaction in visual cortex is still poorly understood. To investigate this interaction, we recorded neuronal activity from retinal ganglion cells and V1 cortical cells in macaques and measured their visual responses to grating stimuli that had either luminance contrast (luminance grating), chromatic contrast (chromatic grating), or a combination of the two (compound grating). As with parvocellular or koniocellular retinal ganglion cells, some V1 cells responded mostly to the chromatic contrast of the compound grating. As with magnocellular retinal ganglion cells, other V1 cells responded mostly to the luminance contrast and generated a frequency-doubled response to equiluminant chromatic gratings. Unlike magnocellular and parvocellular retinal ganglion cells, V1 cells formed a unimodal distribution for luminance/color preference with a 2- to 4-fold bias toward luminance. V1 cells associated with positive local field potentials in deep layers showed the strongest combined responses to color and luminance and, as a population, V1 cells encoded a diverse combination of luminance/color edges that matched edge distributions of natural scenes. Taken together, these results suggest that the primary visual cortex combines magnocellular and parvocellular retinal inputs to increase cortical receptive field diversity and to optimize visual processing of our natural environment. PMID:24464943

Slope-aspect color shading for parametric surfaces

NASA Technical Reports Server (NTRS)

Moellering, Harold J. (Inventor); Kimerling, A. Jon (Inventor)

1991-01-01

The invention is a method for generating an image of a parametric surface, such as the compass direction toward which each surface element of terrain faces, commonly called the slope-aspect azimuth of the surface element. The method maximizes color contrast to permit easy discrimination of the magnitude, ranges, intervals or classes of a surface parameter while making it easy for the user to visualize the form of the surface, such as a landscape. The four pole colors of the opponent process color theory are utilized to represent intervals or classes at 90 degree angles. The color perceived as having maximum measured luminance is selected to portray the color having an azimuth of an assumed light source and the color showing minimum measured luminance portrays the diametrically opposite azimuth. The 90 degree intermediate azimuths are portrayed by unique colors of intermediate measured luminance, such as red and green. Colors between these four pole colors are used which are perceived as mixtures or combinations of their bounding colors and are arranged progressively between their bounding colors to have perceived proportional mixtures of the bounding colors which are proportional to the interval's angular distance from its bounding colors.

DARPA Neural Network Study: October 1987 - February 1988

DTIC Science & Technology

1989-03-22

LUMINANCE PATCH. NONUNIFORM BOUNDARY BACKGROUND OUTPUT -LA- FEATURE STIMULUS i_L UNIFORM BACKGROUND BOUNDARY LUMINANCE _^N...Problem Area: The recognition of satellites by their Long-Wave Infrared ( LWIR ) signatures. Prior Approach: Human expert. Neural Network Approach...other than range and atmospheric attenuation compensation) LWIR satellite signatures (one- dimensional temporal plots of non-spatially- resolved

Best estimate of luminal cross-sectional area of coronary arteries from angiograms

NASA Technical Reports Server (NTRS)

Lee, P. L.; Selzer, R. H.

1988-01-01

We have reexamined the problem of estimating the luminal area of an elliptically-shaped coronary artery cross section from two or more radiographic diameter measurements. The expected error is found to be much smaller than the maximum potential error. In the cae of two orthogonal views, closed form expressions have been derived for calculating the area and the uncertainty. Assuming that the underlying ellipse has limited ellipticity (major/minor axis ratio less than five), it is shown that the average uncertainty in the area is less than 14 percent. When more than two views are available, we suggest using a least-squares fit method to extract all available information from the data.

Breast screen new South wales generally demonstrates good radiologic viewing conditions.

PubMed

Soh, BaoLin Pauline; Lee, Warwick; Diffey, Jennifer L; McEntee, Mark F; Kench, Peter L; Reed, Warren M; Brennan, Patrick C

2013-08-01

This study measured reading workstation monitors and the viewing environment currently available within BreastScreen New South Wales (BSNSW) centres to determine levels of adherence to national and international guidelines. Thirteen workstations from four BSNSW service centres were assessed using the American Association of Physicists in Medicine Task Group 18 Quality Control test pattern. Reading workstation monitor performance and ambient light levels when interpreting screening mammographic images were assessed using spectroradiometer CS-2000 and chroma meter CL-200. Overall, radiologic monitors within BSNSW were operating at good acceptable levels. Some non-adherence to published guidelines included the percentage difference in maximum luminance between pairs of primary monitors at individual workstations (61.5 % or 30.8 % of workstations depending on specific guidelines), maximum luminance (23.1 % of workstations), luminance non-uniformity (11.5 % of workstations) and minimum luminance (3.8 % of workstations). A number of ambient light measurements did not comply with the only available evidence-based guideline relevant to the methodology used in this study. Larger ambient light variations across sites are shown when monitors were switched off, suggesting that differences in ambient lighting between sites can be masked when a standard mammogram is displayed for photometric measurements. Overall, BSNSW demonstrated good adherence to available guidelines, although some non-compliance has been shown. Recently updated United Kingdom and Australian guidelines should help reduce confusion generated by the plethora and sometimes dated nature of currently available recommendations.

Mixing of Chromatic and Luminance Retinal Signals in Primate Area V1.

PubMed

Li, Xiaobing; Chen, Yao; Lashgari, Reza; Bereshpolova, Yulia; Swadlow, Harvey A; Lee, Barry B; Alonso, Jose Manuel

2015-07-01

Vision emerges from activation of chromatic and achromatic retinal channels whose interaction in visual cortex is still poorly understood. To investigate this interaction, we recorded neuronal activity from retinal ganglion cells and V1 cortical cells in macaques and measured their visual responses to grating stimuli that had either luminance contrast (luminance grating), chromatic contrast (chromatic grating), or a combination of the two (compound grating). As with parvocellular or koniocellular retinal ganglion cells, some V1 cells responded mostly to the chromatic contrast of the compound grating. As with magnocellular retinal ganglion cells, other V1 cells responded mostly to the luminance contrast and generated a frequency-doubled response to equiluminant chromatic gratings. Unlike magnocellular and parvocellular retinal ganglion cells, V1 cells formed a unimodal distribution for luminance/color preference with a 2- to 4-fold bias toward luminance. V1 cells associated with positive local field potentials in deep layers showed the strongest combined responses to color and luminance and, as a population, V1 cells encoded a diverse combination of luminance/color edges that matched edge distributions of natural scenes. Taken together, these results suggest that the primary visual cortex combines magnocellular and parvocellular retinal inputs to increase cortical receptive field diversity and to optimize visual processing of our natural environment. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Distinguishing Low-Risk Luminal A Breast Cancer Subtypes with Ki-67 and p53 Is More Predictive of Long-Term Survival

PubMed Central

Lee, Se Kyung; Bae, Soo Youn; Lee, Jun Ho; Lee, Hyun-Chul; Yi, Hawoo; Kil, Won Ho; Lee, Jeong Eon; Kim, Seok Won; Nam, Seok Jin

2015-01-01

Overexpression of p53 is the most frequent genetic alteration in breast cancer. Recently, many studies have shown that the expression of mutant p53 differs for each subtype of breast cancer and is associated with different prognoses. In this study, we aimed to determine the suitable cut-off value to predict the clinical outcome of p53 overexpression and its usefulness as a prognostic factor in each subtype of breast cancer, especially in luminal A breast cancer. Approval was granted by the Institutional Review Board of Samsung Medical Center. We analyzed a total of 7,739 patients who were surgically treated for invasive breast cancer at Samsung Medical Center between Dec 1995 and Apr 2013. Luminal A subtype was defined as ER&PR + and HER2- and was further subclassified according to Ki-67 and p53 expression as follows: luminal A (Ki-67-,p53-), luminal A (Ki-67+, p53-), luminal A (Ki-67 -, p53+) and luminal A (Ki-67+, p53+). Low-risk luminal A subtype was defined as negative for both Ki-67 and p53 (luminal A [ki-67-, p53-]), and others subtypes were considered to be high-risk luminal A breast cancer. A cut-off value of 10% for p53 was a good predictor of clinical outcome in all patients and luminal A breast cancer patients. The prognostic role of p53 overexpression for OS and DFS was only significant in luminal A subtype. The combination of p53 and Ki-67 has been shown to have the best predictive power as calculated by the area under curve (AUC), especially for long-term overall survival. In this study, we have shown that overexpression of p53 and Ki-67 could be used to discriminate low-risk luminal A subtype in breast cancer. Therefore, using the combination of p53 and Ki-67 expression in discriminating low-risk luminal A breast cancer may improve the prognostic power and provide the greatest clinical utility. PMID:26241661

Distinguishing Low-Risk Luminal A Breast Cancer Subtypes with Ki-67 and p53 Is More Predictive of Long-Term Survival.

PubMed

Lee, Se Kyung; Bae, Soo Youn; Lee, Jun Ho; Lee, Hyun-Chul; Yi, Hawoo; Kil, Won Ho; Lee, Jeong Eon; Kim, Seok Won; Nam, Seok Jin

2015-01-01

Overexpression of p53 is the most frequent genetic alteration in breast cancer. Recently, many studies have shown that the expression of mutant p53 differs for each subtype of breast cancer and is associated with different prognoses. In this study, we aimed to determine the suitable cut-off value to predict the clinical outcome of p53 overexpression and its usefulness as a prognostic factor in each subtype of breast cancer, especially in luminal A breast cancer. Approval was granted by the Institutional Review Board of Samsung Medical Center. We analyzed a total of 7,739 patients who were surgically treated for invasive breast cancer at Samsung Medical Center between Dec 1995 and Apr 2013. Luminal A subtype was defined as ER&PR + and HER2- and was further subclassified according to Ki-67 and p53 expression as follows: luminal A (Ki-67-,p53-), luminal A (Ki-67+, p53-), luminal A (Ki-67 -, p53+) and luminal A (Ki-67+, p53+). Low-risk luminal A subtype was defined as negative for both Ki-67 and p53 (luminal A [ki-67-, p53-]), and others subtypes were considered to be high-risk luminal A breast cancer. A cut-off value of 10% for p53 was a good predictor of clinical outcome in all patients and luminal A breast cancer patients. The prognostic role of p53 overexpression for OS and DFS was only significant in luminal A subtype. The combination of p53 and Ki-67 has been shown to have the best predictive power as calculated by the area under curve (AUC), especially for long-term overall survival. In this study, we have shown that overexpression of p53 and Ki-67 could be used to discriminate low-risk luminal A subtype in breast cancer. Therefore, using the combination of p53 and Ki-67 expression in discriminating low-risk luminal A breast cancer may improve the prognostic power and provide the greatest clinical utility.

Display characterization by eye: contrast ratio and discrimination throughout the grayscale

NASA Astrophysics Data System (ADS)

Gille, Jennifer; Arend, Larry; Larimer, James O.

2004-06-01

We have measured the ability of observers to estimate the contrast ratio (maximum white luminance / minimum black or gray) of various displays and to assess luminous discrimination over the tonescale of the display. This was done using only the computer itself and easily-distributed devices such as neutral density filters. The ultimate goal of this work is to see how much of the characterization of a display can be performed by the ordinary user in situ, in a manner that takes advantage of the unique abilities of the human visual system and measures visually important aspects of the display. We discuss the relationship among contrast ratio, tone scale, display transfer function and room lighting. These results may contribute to the development of applications that allow optimization of displays for the situated viewer / display system without instrumentation and without indirect inferences from laboratory to workplace.

Modular Representation of Luminance Polarity In the Superficial Layers Of Primary Visual Cortex

PubMed Central

Smith, Gordon B.; Whitney, David E.; Fitzpatrick, David

2016-01-01

Summary The spatial arrangement of luminance increments (ON) and decrements (OFF) falling on the retina provides a wealth of information used by central visual pathways to construct coherent representations of visual scenes. But how the polarity of luminance change is represented in the activity of cortical circuits remains unclear. Using wide-field epifluorescence and two-photon imaging we demonstrate a robust modular representation of luminance polarity (ON or OFF) in the superficial layers of ferret primary visual cortex. Polarity-specific domains are found with both uniform changes in luminance and single light/dark edges, and include neurons selective for orientation and direction of motion. The integration of orientation and polarity preference is evident in the selectivity and discrimination capabilities of most layer 2/3 neurons. We conclude that polarity selectivity is an integral feature of layer 2/3 neurons, ensuring that the distinction between light and dark stimuli is available for further processing in downstream extrastriate areas. PMID:26590348

Sub-luminous γ-ray pulsars

DOE PAGES

Romani, R. W.; Kerr, M.; Craig, H. A.; ...

2011-08-17

Here, most pulsars observed by the Fermi Large Area Telescope have γ-ray luminosities scaling with spin-down powermore » $${\\dot{E}}$$ as $$L_\\gamma \\approx ({\\dot{E}}\\, \\times \\, 10^{33}\\,{\\rm erg \\,s^{-1}})^{1/2}$$. However, there exist one detection and several upper limits an order of magnitude or more fainter than this trend. We describe these "sub-luminous" γ-ray pulsars and discuss the case for this being an orientation effect. Of the 12 known young radio pulsars with $${\\dot{E}}>10^{34}\\, {\\rm erg\\,s^{-1}}$$ and d ≤ 2 kpc several are substantially sub-luminous. The limited available geometrical constraints favor aligned geometries for these pulsars, although no one case for alignment is compelling. In this scenario GeV emission detected from such sub-luminous pulsars can be due to a lower altitude, lower-power accelerator gap.« less

Figure-ground segregation by motion contrast and by luminance contrast.

PubMed

Regan, D; Beverley, K I

1984-05-01

Some naturally camouflaged objects are invisible unless they move; their boundaries are then defined by motion contrast between object and background. We compared the visual detection of such camouflaged objects with the detection of objects whose boundaries were defined by luminance contrast. The summation field area is 0.16 deg2 , and the summation time constant is 750 msec for parafoveally viewed objects whose boundaries are defined by motion contrast; these values are, respectively, about 5 and 12 times larger than the corresponding values for objects defined by luminance contrast. The log detection threshold is proportional to the eccentricity for a camouflaged object of constant area. The effect of eccentricity on threshold is less for large objects than for small objects. The log summation field diameter for detecting camouflaged objects is roughly proportional to the eccentricity, increasing to about 20 deg at 32-deg eccentricity. In contrast to the 100:1 increase of summation area for detecting camouflaged objects, the temporal summation time constant changes by only 40% between eccentricities of 0 and 16 deg.

Optical design of a street lamp based on dual-module chip-on-board LED arrays.

PubMed

Ge, Aiming; Cai, Jinlin; Chen, Dehua; Shu, Hongyun; Qiu, Peng; Wang, Junwei; Zhu, Ling

2014-09-01

We design and propose a compact street lamp based on dual-module chip-on-board LED. The street lamp is composed of six faceted reflectors. It can direct the luminous flux and form uniform illumination on the target area, and it effectively reduces power consumption. We have conducted both simulations and prototype measurements. The test results show good optical performance in that the uniformity of luminance reaches 0.58 for LED lamp zigzag arrangements and 0.60 for LED lamp double-side arrangements. The average luminance can fulfill the requirements in Chinese road lighting Standard CJJ45-2006.

30 CFR 75.1719-3 - Methods of measurement; light measuring instruments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... §§ 75.1719.1(e)(1) through 75.1719-1(e)(3) luminous intensity measurements of the face, ribs, roof... approximate center of the working place with the cutting, loading, or drilling head toward the face and not more than 3 feet from the face. (2) In areas of working places specified in § 75.1719-1(e)(4) luminous...

30 CFR 75.1719-3 - Methods of measurement; light measuring instruments.

Code of Federal Regulations, 2013 CFR

2013-07-01

... §§ 75.1719.1(e)(1) through 75.1719-1(e)(3) luminous intensity measurements of the face, ribs, roof... approximate center of the working place with the cutting, loading, or drilling head toward the face and not more than 3 feet from the face. (2) In areas of working places specified in § 75.1719-1(e)(4) luminous...

30 CFR 75.1719-3 - Methods of measurement; light measuring instruments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... §§ 75.1719.1(e)(1) through 75.1719-1(e)(3) luminous intensity measurements of the face, ribs, roof... approximate center of the working place with the cutting, loading, or drilling head toward the face and not more than 3 feet from the face. (2) In areas of working places specified in § 75.1719-1(e)(4) luminous...

30 CFR 75.1719-3 - Methods of measurement; light measuring instruments.

Code of Federal Regulations, 2012 CFR

2012-07-01

... §§ 75.1719.1(e)(1) through 75.1719-1(e)(3) luminous intensity measurements of the face, ribs, roof... approximate center of the working place with the cutting, loading, or drilling head toward the face and not more than 3 feet from the face. (2) In areas of working places specified in § 75.1719-1(e)(4) luminous...

30 CFR 75.1719-3 - Methods of measurement; light measuring instruments.

Code of Federal Regulations, 2011 CFR

2011-07-01

... §§ 75.1719.1(e)(1) through 75.1719-1(e)(3) luminous intensity measurements of the face, ribs, roof... approximate center of the working place with the cutting, loading, or drilling head toward the face and not more than 3 feet from the face. (2) In areas of working places specified in § 75.1719-1(e)(4) luminous...

Lessons learned in dealing with self luminous exit signs.

PubMed

Linsley, Mark E

2005-02-01

Self-luminous signs are generally licensed consumer products used to identifying exits, handicap accessibility areas, parking lots, no smoking areas, life boat locations, and emergency stair locations. While purchasers of these signs are exempt from the requirement of applying for a specific license, they are not exempt from all other requirements concerning radioactive material. And they might not be exempt from the liability that can result from lost or damaged signs and improper disposal. A review of the potential for contamination from these signs is presented along with suggestions for handling a contaminating event involving a damaged sign.

Luminance compensation for AMOLED displays using integrated MIS sensors

NASA Astrophysics Data System (ADS)

Vygranenko, Yuri; Fernandes, Miguel; Louro, Paula; Vieira, Manuela

2017-05-01

Active-matrix organic light-emitting diodes (AMOLEDs) are ideal for future TV applications due to their ability to faithfully reproduce real images. However, pixel luminance can be affected by instability of driver TFTs and aging effect in OLEDs. This paper reports on a pixel driver utilizing a metal-insulator-semiconductor (MIS) sensor for luminance control of the OLED element. In the proposed pixel architecture for bottom-emission AMOLEDs, the embedded MIS sensor shares the same layer stack with back-channel etched a Si:H TFTs to maintain the fabrication simplicity. The pixel design for a large-area HD display is presented. The external electronics performs image processing to modify incoming video using correction parameters for each pixel in the backplane, and also sensor data processing to update the correction parameters. The luminance adjusting algorithm is based on realistic models for pixel circuit elements to predict the relation between the programming voltage and OLED luminance. SPICE modeling of the sensing part of the backplane is performed to demonstrate its feasibility. Details on the pixel circuit functionality including the sensing and programming operations are also discussed.

Materials for Optical Cryocoolers

DTIC Science & Technology

2013-12-07

Melgaard, R. I . Epstein, A. Di Lieto, M. Tonelli, and M. Sheik- Bahae , “Precise determination of minimum achievable temperature for solid-state optical...M. G. Brik and K. W. Krämer, J. Lumin., 2013, 136, 221–239. 13 D. V. Seletskiy, M. P. Hehlen, R. I . Epstein and M. Sheik- Bahae , Adv. Opt... I . Epstein, Phys. Rev. Lett., 2004, 92, 24740. 16 M. Sheik- Bahae and R. I . Epstein, Nat. Photonics, 2007, 1, 693–699. 17 G. Rupper, N. H. Kwong and R

The effects of intrathecal nicergoline and nimodipine in cerebral vasospasm: an experimental study in rabbits.

PubMed

Solmaz, Ilker; Onal, Mehmet Bulent; Civelek, Erdinc; Kircelli, Atilla; Ongoru, Onder; Ugurel, Sahin; Erdogan, Ersin; Gonul, Engin

2011-01-01

the aim of this study was to assess and to compare the ability of intrathecal nicergoline and nimodipine in prevention of cerebral vasospasm in a rabbit model of subarachnoid hemorrhage (SAH). twenty male New Zealand white rabbits were allocated into four groups randomly. Subarachnoid hemorrhage was induced by injecting autologous blood into the cisterna magna. The treatment groups were as follows: (1) control [no SAH (n = 5)], (2) SAH only (n = 5), (3) SAH plus nimodipine (n = 5), and (4) SAH plus nicergoline (n = 5). there was a statistically significant difference between the mean basilar artery cross-sectional areas and the mean arterial wall thickness measurements of the control and SAH-only groups (p < 0.05). Basilar artery vessel diameter and luminal section areas in group 3 were significantly higher than in group 2 (p < 0.05). Basilar artery vessel diameter and basilar artery luminal section areas in group 4 were significantly higher than in group 2 (p < 0.05). There was no significant difference between basilar artery vessel diameter and basilar artery luminal section areas in group 3 and group 4. these findings demonstrate that intrathecal nicergoline has a vasodilatatory effect in an experimental model of SAH in rabbits but not more than that of nimodipine.

A methodology for luminance map retrieval using airborne hyperspectral and photogrammetric data

NASA Astrophysics Data System (ADS)

Pipia, Luca; Alamús, Ramon; Tardà, Anna; Pérez, Fernando; Palà, Vicenç; Corbera, Jordi

2014-10-01

This paper puts forward a methodology developed at the Institut Cartogràfic i Geològic de Catalunya (ICGC) to quantify upwelling light flux using hyperspectral and photogrammetric airborne data. The work was carried out in the frame of a demonstrative study requested by the municipality of Sant Cugat del Vallès, in the vicinity of Barcelona (Spain), and aimed to envisage a new approach to assess artificial lighting policies and actions as alternative to field campaigns. Hyperspectral and high resolution multispectral/panchromatic data were acquired simultaneously over urban areas. In order to avoid moon light contributions, data were acquired during the first days of new moon phase. Hyperspectral data were radiometrically calibrated. Then, National Center for Environmental Prediction (NCEP) atmospheric profiles were employed to estimate the actual Column Water Vapor (CWV) to be passed to ModTran5.0 for the atmospheric transmissivity τ calculation. At-the-ground radiance was finally integrated using the photopic sensitivity curve to generate a luminance map (cdm-2) of the flown area by mosaicking the different flight tracks. In an attempt to improve the spatial resolution and enhance the dynamic range of the luminance map, a sensor-fusion strategy was finally looked into. DMC Photogrammetric data acquired simultaneously to hyperspectral information were converted into at-the-ground radiance and upscaled to CASI spatial resolution. High-resolution (HR) luminance maps with enhanced dynamic range were finally generated by linearly fitting up-scaled DMC mosaics to the CASI-based luminance information. In the end, a preliminary assessment of the methodology is carried out using non-simultaneous in-situ measurements.

Assessment of carotid stenosis using three-dimensional T2-weighted dark blood imaging: Initial experience.

PubMed

Mihai, Georgeta; Winner, Marshall W; Raman, Subha V; Rajagopalan, Sanjay; Simonetti, Orlando P; Chung, Yiu-Cho

2012-02-01

To evaluate the use of a T2-weighted SPACE sequence (T2w-SPACE) to assess carotid stenosis via several methods and compare its performance with contrast-enhanced magnetic resonance angiography (ceMRA). Fifteen patients with carotid atherosclerosis underwent dark blood (DB)-MRI using a 3D turbo spin echo with variable flip angles sequence (T2w-SPACE) and ceMRA. Images were coregistered and evaluated by two observers. Comparisons were made for luminal diameter, luminal area, degree of luminal stenosis (NASCET: North American Symptomatic Endarterectomy Trial; ECST: European Carotid Surgery Trial, and area stenosis), and vessel wall area. Degree of NASCET stenosis was clinically classified as mild (<50%), moderate (50%-69%), or severe (>69%). Excellent agreement was seen between ceMRA and T2w-SPACE and between observers for assessment of lumen diameter, lumen area, vessel wall area, and degree of NASCET stenosis (r > 0.80, P < 0.001). ECST stenosis was consistently higher than NASCET stenosis (48 ± 14% vs. 24 ± 22%, P < 0.001). Area stenosis (72 ± 2%) was significantly higher (P < 0.001) than both ESCT and NASCET stenosis. DB-MRI of carotid arteries using T2w-SPACE is clinically feasible. It provides accurate measurements of lumen size and degree of stenosis in comparison with ceMRA and offers a more reproducible measure of ECST stenosis than ceMRA. Copyright © 2011 Wiley Periodicals, Inc.

Sub-luminal pulses from cosmic ray air showers

NASA Technical Reports Server (NTRS)

Linsley, J.

1985-01-01

Some of the signals produced by air showers in scintillators possess a distinctive feature, a sub-luminal pulse (SLP) following the normal one with a time delay of approximately 1.5 r/c. The average amplitude of the SLP corresponds to an energy deposit of about 50 MeV, three times as much as is deposited in a typical scintillator by vertical minimum ionizing muons. The SLP account for approximately 5% of the energy deposited in the atmosphere by IR showers with energy 10 to the 10th power GeV at impact parameters 1 km. Assuming that these pulses are due to neutrons travelling with a speed slightly less than c, they provide a unique means of estimating E sub h, the energy deposited by slow hadrons, in showers of this very high energy. On the other hand, if not allowed for properly, these pulses are liable to cause errors in estimating the impact parameters of large showers from pulse width observations.

Effect of non-Newtonian and pulsatile blood flow on mass transport in the human aorta.

PubMed

Liu, Xiao; Fan, Yubo; Deng, Xiaoyan; Zhan, Fan

2011-04-07

To investigate the effects of both non-Newtonian behavior and the pulsation of blood flow on the distributions of luminal surface LDL concentration and oxygen flux along the wall of the human aorta, we numerically compared a non-Newtonian model with the Newtonian one under both steady flow and in vivo pulsatile flow conditions using a human aorta model constructed from MRI images. The results showed that under steady flow conditions, although the shear thinning non-Newtonian nature of blood could elevate wall shear stress (WSS) in most regions of the aorta, especially areas with low WSS, it had little effect on luminal surface LDL concentration (c(w)) in most regions of the aorta. Nevertheless, it could significantly enhance c(w) in areas with high luminal surface LDL concentration through the shear dependent diffusivity of LDLs. For oxygen transport, the shear thinning non-Newtonian nature of blood could slightly reduce oxygen flux in most regions of the aorta, but this effect became much more apparent in areas with already low oxygen flux. The pulsation of blood flow could significantly reduce c(w) and enhance oxygen flux in these disturbed places. In most other regions of the aorta, the oxygen flux was also significantly higher than that for the steady flow simulation. In conclusion, the shear shining non-Newtonian nature of blood has little effect on LDL and oxygen transport in most regions of the aorta, but in the atherogenic-prone areas where luminal surface LDL concentration is high and oxygen flux is low, its effect is apparent. Similar is for the effect of pulsatile flow on the transport of LDLs. But, the pulsation of blood flow can apparently affect oxygen flux in the aorta, especially in areas with low oxygen flux. Copyright © 2011 Elsevier Ltd. All rights reserved.

Prediction of HDR quality by combining perceptually transformed display measurements with machine learning

NASA Astrophysics Data System (ADS)

Choudhury, Anustup; Farrell, Suzanne; Atkins, Robin; Daly, Scott

2017-09-01

We present an approach to predict overall HDR display quality as a function of key HDR display parameters. We first performed subjective experiments on a high quality HDR display that explored five key HDR display parameters: maximum luminance, minimum luminance, color gamut, bit-depth and local contrast. Subjects rated overall quality for different combinations of these display parameters. We explored two models | a physical model solely based on physically measured display characteristics and a perceptual model that transforms physical parameters using human vision system models. For the perceptual model, we use a family of metrics based on a recently published color volume model (ICT-CP), which consists of the PQ luminance non-linearity (ST2084) and LMS-based opponent color, as well as an estimate of the display point spread function. To predict overall visual quality, we apply linear regression and machine learning techniques such as Multilayer Perceptron, RBF and SVM networks. We use RMSE and Pearson/Spearman correlation coefficients to quantify performance. We found that the perceptual model is better at predicting subjective quality than the physical model and that SVM is better at prediction than linear regression. The significance and contribution of each display parameter was investigated. In addition, we found that combined parameters such as contrast do not improve prediction. Traditional perceptual models were also evaluated and we found that models based on the PQ non-linearity performed better.

Data Analysis of Anomalous Luminous Phenomena in Hessdalen

NASA Astrophysics Data System (ADS)

Teodorani, M.

2001-06-01

In the beginning of 1984 a group of Norwegian researchers, supported by external physical scientists, carried out investigations on a luminous phenomenon which was occurring with strong recurrence in the area of Hessdalen in Norway. Such a phenomenon, which was monitored without interruption for 36 days, also by employing several types of instruments, allowed researchers to obtain a precious set of data. At the present time a new station, which has been installed in 1998 in the Hessdalen area and which is supplied with an automatic videocamera, is currently furnishing data in real time. The present paper is devoted to the presentation and discussion of the data analysis and interpretation which have been attempted in order to try to understand the nature of such a phenomenon. The following main results are presented: a) the luminous phenomenon, which appears mostly during the night time and during the winter season, shows a marked radar signature and occurs approximately ! in concomitance with some peculiar magnetic disturbances and sometimes with unexplained radio emission, b) magnetometric data, radar data and some components of radiometric data show some slight correlation with daily solar activity. The hypothesis regarding the formation of solar-driven plasmoids which acquire self-governing EM and magnetic fields, is ventured and discussed. The alternative possibility that solar activity is interfering with a still unknown EM behavior due to the luminous phenomenon is further discussed.

Visual acuity measured with luminance-modulated and contrast-modulated noise letter stimuli in young adults and adults above 50 years old

PubMed Central

Woi, Pui Juan; Kaur, Sharanjeet; Waugh, Sarah J.; Hairol, Mohd Izzuddin

2016-01-01

The human visual system is sensitive in detecting objects that have different luminance level from their background, known as first-order or luminance-modulated (LM) stimuli. We are also able to detect objects that have the same mean luminance as their background, only differing in contrast (or other attributes). Such objects are known as second-order or contrast-modulated (CM), stimuli. CM stimuli are thought to be processed in higher visual areas compared to LM stimuli, and may be more susceptible to ageing. We compared visual acuities (VA) of five healthy older adults (54.0±1.83 years old) and five healthy younger adults (25.4±1.29 years old) with LM and CM letters under monocular and binocular viewing. For monocular viewing, age had no effect on VA [F(1, 8)= 2.50, p> 0.05]. However, there was a significant main effect of age on VA under binocular viewing [F(1, 8)= 5.67, p< 0.05].  Binocular VA with CM letters in younger adults was approximately two lines better than that in older adults. For LM, binocular summation ratios were similar for older (1.16±0.21) and younger (1.15±0.06) adults. For CM, younger adults had higher binocular summation ratio (1.39±0.08) compared to older adults (1.12±0.09). Binocular viewing improved VA with LM letters for both groups similarly. However, in older adults, binocular viewing did not improve VA with CM letters as much as in younger adults. This could reflect a decline of higher visual areas due to ageing process, most likely higher than V1, which may be missed if measured with luminance-based stimuli alone. PMID:28184281

BONA FIDE, STRONG-VARIABLE GALACTIC LUMINOUS BLUE VARIABLE STARS ARE FAST ROTATORS: DETECTION OF A HIGH ROTATIONAL VELOCITY IN HR CARINAE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Groh, J. H.; Damineli, A.; Moises, A. P.

2009-11-01

We report optical observations of the luminous blue variable (LBV) HR Carinae which show that the star has reached a visual minimum phase in 2009. More importantly, we detected absorptions due to Si IV lambdalambda4088-4116. To match their observed line profiles from 2009 May, a high rotational velocity of v{sub rot} approx = 150 +- 20 km s{sup -1} is needed (assuming an inclination angle of 30 deg.), implying that HR Car rotates at approx =0.88 +- 0.2 of its critical velocity for breakup (v{sub crit}). Our results suggest that fast rotation is typical in all strong-variable, bona fide galacticmore » LBVs, which present S-Dor-type variability. Strong-variable LBVs are located in a well-defined region of the HR diagram during visual minimum (the 'LBV minimum instability strip'). We suggest this region corresponds to where v{sub crit} is reached. To the left of this strip, a forbidden zone with v{sub rot}/v{sub crit}>1 is present, explaining why no LBVs are detected in this zone. Since dormant/ex LBVs like P Cygni and HD 168625 have low v{sub rot}, we propose that LBVs can be separated into two groups: fast-rotating, strong-variable stars showing S-Dor cycles (such as AG Car and HR Car) and slow-rotating stars with much less variability (such as P Cygni and HD 168625). We speculate that supernova (SN) progenitors which had S-Dor cycles before exploding (such as in SN 2001ig, SN 2003bg, and SN 2005gj) could have been fast rotators. We suggest that the potential difficulty of fast-rotating Galactic LBVs to lose angular momentum is additional evidence that such stars could explode during the LBV phase.« less

Reproducibility of airway luminal size in asthma measured by HRCT.

PubMed

Brown, Robert H; Henderson, Robert J; Sugar, Elizabeth A; Holbrook, Janet T; Wise, Robert A

2017-10-01

Brown RH, Henderson RJ, Sugar EA, Holbrook JT, Wise RA, on behalf of the American Lung Association Airways Clinical Research Centers. Reproducibility of airway luminal size in asthma measured by HRCT. J Appl Physiol 123: 876-883, 2017. First published July 13, 2017; doi:10.1152/japplphysiol.00307.2017.-High-resolution CT (HRCT) is a well-established imaging technology used to measure lung and airway morphology in vivo. However, there is a surprising lack of studies examining HRCT reproducibility. The CPAP Trial was a multicenter, randomized, three-parallel-arm, sham-controlled 12-wk clinical trial to assess the use of a nocturnal continuous positive airway pressure (CPAP) device on airway reactivity to methacholine. The lack of a treatment effect of CPAP on clinical or HRCT measures provided an opportunity for the current analysis. We assessed the reproducibility of HRCT imaging over 12 wk. Intraclass correlation coefficients (ICCs) were calculated for individual airway segments, individual lung lobes, both lungs, and air trapping. The ICC [95% confidence interval (CI)] for airway luminal size at total lung capacity ranged from 0.95 (0.91, 0.97) to 0.47 (0.27, 0.69). The ICC (95% CI) for airway luminal size at functional residual capacity ranged from 0.91 (0.85, 0.95) to 0.32 (0.11, 0.65). The ICC measurements for airway distensibility index and wall thickness were lower, ranging from poor (0.08) to moderate (0.63) agreement. The ICC for air trapping at functional residual capacity was 0.89 (0.81, 0.94) and varied only modestly by lobe from 0.76 (0.61, 0.87) to 0.95 (0.92, 0.97). In stable well-controlled asthmatic subjects, it is possible to reproducibly image unstimulated airway luminal areas over time, by region, and by size at total lung capacity throughout the lungs. Therefore, any changes in luminal size on repeat CT imaging are more likely due to changes in disease state and less likely due to normal variability. NEW & NOTEWORTHY There is a surprising lack of studies examining the reproducibility of high-resolution CT in asthma. The current study examined reproducibility of airway measurements. In stable well-controlled asthmatic subjects, it is possible to reproducibly image airway luminal areas over time, by region, and by size at total lung capacity throughout the lungs. Therefore, any changes in luminal size on repeat CT imaging are more likely due to changes in disease state and less likely due to normal variability. Copyright © 2017 the American Physiological Society.

Assessment of display performance for medical imaging systems: Executive summary of AAPM TG18 report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Samei, Ehsan; Badano, Aldo; Chakraborty, Dev

Digital imaging provides an effective means to electronically acquire, archive, distribute, and view medical images. Medical imaging display stations are an integral part of these operations. Therefore, it is vitally important to assure that electronic display devices do not compromise image quality and ultimately patient care. The AAPM Task Group 18 (TG18) recently published guidelines and acceptance criteria for acceptance testing and quality control of medical display devices. This paper is an executive summary of the TG18 report. TG18 guidelines include visual, quantitative, and advanced testing methodologies for primary and secondary class display devices. The characteristics, tested in conjunction withmore » specially designed test patterns (i.e., TG18 patterns), include reflection, geometric distortion, luminance, the spatial and angular dependencies of luminance, resolution, noise, glare, chromaticity, and display artifacts. Geometric distortions are evaluated by linear measurements of the TG18-QC test pattern, which should render distortion coefficients less than 2%/5% for primary/secondary displays, respectively. Reflection measurements include specular and diffuse reflection coefficients from which the maximum allowable ambient lighting is determined such that contrast degradation due to display reflection remains below a 20% limit and the level of ambient luminance (L{sub amb}) does not unduly compromise luminance ratio (LR) and contrast at low luminance levels. Luminance evaluation relies on visual assessment of low contrast features in the TG18-CT and TG18-MP test patterns, or quantitative measurements at 18 distinct luminance levels of the TG18-LN test patterns. The major acceptable criteria for primary/secondary displays are maximum luminance of greater than 170/100 cd/m{sup 2}, LR of greater than 250/100, and contrast conformance to that of the grayscale standard display function (GSDF) of better than 10%/20%, respectively. The angular response is tested to ascertain the viewing cone within which contrast conformance to the GSDF is better than 30%/60% and LR is greater than 175/70 for primary/secondary displays, or alternatively, within which the on-axis contrast thresholds of the TG18-CT test pattern remain discernible. The evaluation of luminance spatial uniformity at two distinct luminance levels across the display faceplate using TG18-UNL test patterns should yield nonuniformity coefficients smaller than 30%. The resolution evaluation includes the visual scoring of the CX test target in the TG18-QC or TG18-CX test patterns, which should yield scores greater than 4/6 for primary/secondary displays. Noise evaluation includes visual evaluation of the contrast threshold in the TG18-AFC test pattern, which should yield a minimum of 3/2 targets visible for primary/secondary displays. The guidelines also include methodologies for more quantitative resolution and noise measurements based on MTF and NPS analyses. The display glare test, based on the visibility of the low-contrast targets of the TG18-GV test pattern or the measurement of the glare ratio (GR), is expected to yield scores greater than 3/1 and GRs greater than 400/150 for primary/secondary displays. Chromaticity, measured across a display faceplate or between two display devices, is expected to render a u{sup '},v{sup '} color separation of less than 0.01 for primary displays. The report offers further descriptions of prior standardization efforts, current display technologies, testing prerequisites, streamlined procedures and timelines, and TG18 test patterns.« less

The Large Area KX Quasar Survey: Photometric Redshift Selection and the Complete Quasar Catalogue

NASA Astrophysics Data System (ADS)

Maddox, Natasha; Hewett, P. C.; Peroux, C.

2013-01-01

We have completed a large area, ˜600 square degree, spectroscopic survey for luminous quasars flux-limited in the K-band. The survey utilises the UKIRT Infrared Deep Sky Survey (UKIDSS) Large Area Survey (LAS) in regions of sky within the Sloan Digital Sky Survey (SDSS) footprint. We exploit the K-band excess (KX) of all quasars with respect to Galactic stars in combination with a custom-built photometric redshift/classification scheme to identify quasar candidates for spectroscopic follow-up observations. The survey is complete to K≤16.6, and includes >3200 known quasars from the SDSS, with more than 250 additional confirmed quasars from the KX-selection which eluded the SDSS quasar selection algorithm. The selection is >95% complete with respect to known SDSS quasars and >95% efficient, largely independent of redshift and magnitude. The KX-selected quasars will provide new constraints on the fraction of luminous quasars reddened by dust with E(B-V)≤0.5 mag. Several projects utilizing the KX quasars are ongoing, including a spectroscopic campaign searching for dusty quasar intervening absorption systems. The KX survey is a well-defined sample of quasars useful for investigating the properties of luminous quasars with intermediate levels of dust extinction either within their host galaxies or due to intervening absorption systems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reitan, J.B.; Feren, K.

The luminal surface of mouse bladder urothelium was studied by scanning microscopy 1 year after irradiation with 0, 10 and 20 Gy respectively. The controls that were anaesthetized only displayed surface characteristics indistinguishable from normal urothelium. Irradiation with 10 Gy did not result in marked overall changes in the scanning electron microscopic features of the luminal aspect, but in some areas alterations comparable to the alterations after 20 Gy were observed. After irradiation with 20 Gy focal hyperplastic areas, superficial early ulceration and dedifferentiation of cover cells were seen. The dedifferentiation to featureless cells is probably not associated with increasedmore » proliferation, which in focally hyperplastic areas gives rise to a cobblestone or fuzzy appearance with small superficial cells and with many different surface features. The featureless cells may represent degenerative or agonal changes only, but a preneoplastic nature cannot be ruled out.« less

Predicting the emissive power of hydrocarbon pool fires.

PubMed

Muñoz, Miguel; Planas, Eulàlia; Ferrero, Fabio; Casal, Joaquim

2007-06-18

The emissive power (E) of a flame depends on the size of the fire and the type of fuel. In fact, it changes significantly over the flame surface: the zones of luminous flame have high emittance, while those covered by smoke have low E values. The emissive power of each zone (that is, the luminous or clear flame and the non-luminous or smoky flame) and the portion of total flame area they occupy must be assessed when a two-zone model is used. In this study, data obtained from an experimental set-up were used to estimate the emissive power of fires and its behaviour as a function of pool size. The experiments were performed using gasoline and diesel oil as fuel. Five concentric circular pools (1.5, 3, 4, 5 and 6m in diameter) were used. Appropriate instruments were employed to determine the main features of the fires. By superimposing IR and VHS images it was possible to accurately identify the luminous and non-luminous zones of the fire. Mathematical expressions were obtained that give a more accurate prediction of E(lum), E(soot) and the average emissive power of a fire as a function of its luminous and smoky zones. These expressions can be used in a two-zone model to obtain a better prediction of the thermal radiation. The value of the radiative fraction was determined from the thermal flux measured with radiometers. An expression is also proposed for estimating the radiative fraction.

Learning to identify contrast-defined letters in peripheral vision

PubMed Central

Chung, Susana T.L.; Levi, Dennis M.; Li, Roger W.

2009-01-01

Performance for identifying luminance-defined letters in peripheral vision improves with training. The purpose of the present study was to examine whether performance for identifying contrast-defined letters also improves with training in peripheral vision, and whether any improvement transfers to luminance-defined letters. Eight observers were trained to identify contrast-defined letters presented singly at 10° eccentricity in the inferior visual field. Before and after training, we measured observers’ thresholds for identifying luminance-defined and contrast-defined letters, embedded within a field of white luminance noise (maximum luminance contrast = 0, 0.25, and 0.5), at the same eccentric location. Each training session consisted of 10 blocks (100 trials per block) of identifying contrast-defined letters at a background noise contrast of 0.5. Letters (x-height = 4.2°) were the 26 lowercase letters of the Times-Roman alphabet. Luminance-defined letters were generated by introducing a luminance difference between the stimulus letter and its mid-gray background. The background noise covered both the letter and its background. Contrast-defined letters were generated by introducing a differential noise contrast between the group of pixels that made up the stimulus letter and the group of pixels that made up the background. Following training, observers showed a significant reduction in threshold for identifying contrast-defined letters (p < 0.0001). Averaged across observers and background noise contrasts, the reduction was 25.8%, with the greatest reduction (32%) occurring at the trained background noise contrast. There was virtually no transfer of improvement to luminance-defined letters, or to an untrained letter size (2× original), or an untrained retinal location (10° superior field). In contrast, learning transferred completely to the untrained contralateral eye. Our results show that training improves performance for identifying contrast-defined letters in peripheral vision. This perceptual learning effect seems to be stimulus-specific, as it shows no transfer to the identification of luminance-defined letters. The complete interocular transfer, and the retinotopic (retinal location) and size specificity of the learning effect are consistent with the properties of neurons in early visual area V2. PMID:16337252

Morphometric Study of the Mare Oviductal Mucosa at Different Reproductive Stages.

PubMed

Mouguelar, Horacio; Díaz, Tomás; Borghi, Damiana; Quinteros, Rolando; Bonino, Facundo; Apichela, Silvana Andrea; Aguilar, José Javier

2015-11-01

The objectives of this work were to describe some morphometric characteristics and to establish quantitative parameters of different regions of the equine oviductal mucosa from the isthmus, ampullary-isthmic junction (AIJ), and ampulla. Twenty-one mixed-bred mares were used for this study. Mares were selected in the following reproductive phases: anestrus, estrus, and diestrus. The left oviducts were examined with light microscopy, and rights ones were studied through the intraoviductal molds. The isthmus showed the smallest luminal area, mucosal area, epithelial perimeter, and luminal diameter. On the molds surfaces, some grooves extended as longitudinal canals, reducing their depth as they approached to the AIJ. Several small height projections, some obliquely positioned towards utero-tubal junction, were observed in all reproductive phases. These formations may represent pockets or cul-de-sacs in the basal areas of the epithelial folds. The AIJ mucosa gradually changed from the smooth isthmic region toward highly folded ampulla. The number and complexity of epithelial folds showed moderate increase in the same way that many of the morphometric parameters. Multiple curves were observed on the molds of the AIJ, creating a zigzag path in the oviductal lumen. In the ampulla, the high branched epithelial folds occupied most of the lumen, leaving a small luminal area free. A linear relationship between epithelial perimeter and mucosal area was found. The presence of glandular-like structures was observed in all the reproductive stages studied. The equine endosalpinx reveals a highly complex tridimensional arrangement where each region shows very particular and specific designs. © 2015 Wiley Periodicals, Inc.

Active Luminous Blue Variables in the Large Magellanic Cloud

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walborn, Nolan R.; Gamen, Roberto C.; Lajús, Eduardo Fernández

We present extensive spectroscopic and photometric monitoring of two famous and currently highly active luminous blue variables (LBVs) in the Large Magellanic Cloud (LMC), together with more limited coverage of three further, lesser known members of the class. R127 was discovered as an Ofpe/WN9 star in the 1970s but entered a classical LBV outburst in or about 1980 that is still in progress, thus enlightening us about the minimum state of such objects. R71 is currently the most luminous star in the LMC and continues to provide surprises, such as the appearance of [Ca ii] emission lines, as its spectralmore » type becomes unprecedentedly late. Most recently, R71 has developed inverse P Cyg profiles in many metal lines. The other objects are as follows: HDE 269582, now a “second R127” that has been followed from Ofpe/WN9 to A type in its current outburst; HDE 269216, which changed from late B in 2014 to AF in 2016, its first observed outburst; and R143 in the 30 Doradus outskirts. The light curves and spectroscopic transformations are correlated in remarkable detail and their extreme reproducibility is emphasized, both for a given object and among all of them. It is now believed that some LBVs proceed directly to core collapse. One of these unstable LMC objects may thus oblige in the near future, teaching us even more about the final stages of massive stellar evolution.« less

Active Luminous Blue Variables in the Large Magellanic Cloud

NASA Astrophysics Data System (ADS)

Walborn, Nolan R.; Gamen, Roberto C.; Morrell, Nidia I.; Barbá, Rodolfo H.; Fernández Lajús, Eduardo; Angeloni, Rodolfo

2017-07-01

We present extensive spectroscopic and photometric monitoring of two famous and currently highly active luminous blue variables (LBVs) in the Large Magellanic Cloud (LMC), together with more limited coverage of three further, lesser known members of the class. R127 was discovered as an Ofpe/WN9 star in the 1970s but entered a classical LBV outburst in or about 1980 that is still in progress, thus enlightening us about the minimum state of such objects. R71 is currently the most luminous star in the LMC and continues to provide surprises, such as the appearance of [Ca II] emission lines, as its spectral type becomes unprecedentedly late. Most recently, R71 has developed inverse P Cyg profiles in many metal lines. The other objects are as follows: HDE 269582, now a “second R127” that has been followed from Ofpe/WN9 to A type in its current outburst; HDE 269216, which changed from late B in 2014 to AF in 2016, its first observed outburst; and R143 in the 30 Doradus outskirts. The light curves and spectroscopic transformations are correlated in remarkable detail and their extreme reproducibility is emphasized, both for a given object and among all of them. It is now believed that some LBVs proceed directly to core collapse. One of these unstable LMC objects may thus oblige in the near future, teaching us even more about the final stages of massive stellar evolution.

QR images: optimized image embedding in QR codes.

PubMed

Garateguy, Gonzalo J; Arce, Gonzalo R; Lau, Daniel L; Villarreal, Ofelia P

2014-07-01

This paper introduces the concept of QR images, an automatic method to embed QR codes into color images with bounded probability of detection error. These embeddings are compatible with standard decoding applications and can be applied to any color image with full area coverage. The QR information bits are encoded into the luminance values of the image, taking advantage of the immunity of QR readers against local luminance disturbances. To mitigate the visual distortion of the QR image, the algorithm utilizes halftoning masks for the selection of modified pixels and nonlinear programming techniques to locally optimize luminance levels. A tractable model for the probability of error is developed and models of the human visual system are considered in the quality metric used to optimize the luminance levels of the QR image. To minimize the processing time, the optimization techniques proposed to consider the mechanics of a common binarization method and are designed to be amenable for parallel implementations. Experimental results show the graceful degradation of the decoding rate and the perceptual quality as a function the embedding parameters. A visual comparison between the proposed and existing methods is presented.

Cytokeratin characterization of human prostatic carcinoma and its derived cell lines.

PubMed

Nagle, R B; Ahmann, F R; McDaniel, K M; Paquin, M L; Clark, V A; Celniker, A

1987-01-01

Two murine monoclonal anti-cytokeratin antibodies with defined specificity were shown to distinguish between basal cells and luminal cells in human prostate tissue. Forty-one biopsies or transurethral resection specimens were characterized using these two antibodies. In cases of benign prostatic hyperplasia, focal loss of the basal cell layer was noted in areas of glandular proliferation. Ten cases of adenocarcinoma of the prostate, varying in Gleason's histological grade from 2 to 4, were also studied. In each case the carcinoma was shown to represent the luminal cell phenotype with no evidence of involvement of the basal cell phenotype. An analysis of three established metastatic prostatic carcinoma cell lines (DU-145, PC-3, and LNCaP) using two-dimensional electrophoresis showed that the cytokeratin complement of each cell line was slightly different but retained the phenotype of the luminal cell. It was concluded that during both hyperplasia and neoplastic transformation of the prostate, the luminal cell phenotype is primarily involved and that the basal cell phenotype does not appear to contribute to either intraluminal proliferation or invasive cell populations.

Atmospheric anomalies in summer 1908: Water in the atmosphere

NASA Astrophysics Data System (ADS)

Gladysheva, O. G.

2011-10-01

A gigantic noctilucent cloud field was formed and different solar halos were observed after the Tunguska catastrophe. To explain these anomalous phenomena, it is necessary to assume that a large quantity of water was carried into the atmosphere, which indicates that the Tunguska cosmic body was of a comet origin. According to rough estimates, the quantity of water that is released into the atmosphere as a result of a cosmic body's destruction is more than 1010 kg. The observation of a flying object in an area with a radius of ≥700 km makes it possible to state that the Tunguska cosmic body looked like a luminous coma with a diameter not smaller than ≥10 km and became visible at heights of >500 km. The assumption that the Tunguska cosmic body started disintegrating at a height of ˜1000 km explains the formation of an area where its mater diffused and formed a luminous area above Europe.

Enhancing Three-dimensional Movement Control System for Assemblies of Machine-Building Facilities

NASA Astrophysics Data System (ADS)

Kuzyakov, O. N.; Andreeva, M. A.

2018-01-01

Aspects of enhancing three-dimensional movement control system are given in the paper. Such system is to be used while controlling assemblies of machine-building facilities, which is a relevant issue. The base of the system known is three-dimensional movement control device with optical principle of action. The device consists of multi point light emitter and light receiver matrix. The processing of signals is enhanced to increase accuracy of measurements by switching from discrete to analog signals. Light receiver matrix is divided into four areas, and the output value of each light emitter in each matrix area is proportional to its luminance level. Thus, determing output electric signal value of each light emitter in corresponding area leads to determing position of multipoint light emitter and position of object tracked. This is done by using Case-based reasoning method, the precedent in which is described as integral signal value of each matrix area, coordinates of light receivers, which luminance level is high, and decision to be made in this situation.

Augment clinical measurement using a constraint-based esophageal model

NASA Astrophysics Data System (ADS)

Kou, Wenjun; Acharya, Shashank; Kahrilas, Peter; Patankar, Neelesh; Pandolfino, John

2017-11-01

Quantifying the mechanical properties of the esophageal wall is crucial to understanding impairments of trans-esophageal flow characteristic of several esophageal diseases. However, these data are unavailable owing to technological limitations of current clinical diagnostic instruments that instead display esophageal luminal cross sectional area based on intraluminal impedance change. In this work, we developed an esophageal model to predict bolus flow and the wall property based on clinical measurements. The model used the constraint-based immersed-boundary method developed previously by our group. Specifically, we first approximate the time-dependent wall geometry based on impedance planimetry data on luminal cross sectional area. We then fed these along with pressure data into the model and computed wall tension based on simulated pressure and flow fields, and the material property based on the strain-stress relationship. As examples, we applied this model to augment FLIP (Functional Luminal Imaging Probe) measurements in three clinical cases: a normal subject, achalasia, and eosinophilic esophagitis (EoE). Our findings suggest that the wall stiffness was greatest in the EoE case, followed by the achalasia case, and then the normal. This is supported by NIH Grant R01 DK56033 and R01 DK079902.

Dependence of chromatic responses in V1 on visual field eccentricity and spatial frequency: an fMRI study.

PubMed

D'Souza, Dany V; Auer, Tibor; Frahm, Jens; Strasburger, Hans; Lee, Barry B

2016-03-01

Psychophysical sensitivity to red-green chromatic modulation decreases with visual eccentricity, compared to sensitivity to luminance modulation, even after appropriate stimulus scaling. This is likely to occur at a central, rather than a retinal, site. Blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) responses to stimuli designed to separately stimulate different afferent channels' [red-green, luminance, and short-wavelength (S)-cone] circular gratings were recorded as a function of visual eccentricity (±10  deg) and spatial frequency (SF) in human primary visual cortex (V1) and further visual areas (V2v, V3v). In V1, the SF tuning of BOLD fMRI responses became coarser with eccentricity. For red-green and luminance gratings, similar SF tuning curves were found at all eccentricities. The pattern for S-cone modulation differed, with SF tuning changing more slowly with eccentricity than for the other two modalities. This may be due to the different retinal distribution with eccentricity of this receptor type. A similar pattern held in V2v and V3v. This would suggest that transformation or spatial filtering of the chromatic (red-green) signal occurs beyond these areas.

The perception of object versus objectless motion.

PubMed

Hock, Howard S; Nichols, David F

2013-05-01

Wertheimer, M. (Zeitschrift für Psychologie und Physiologie der Sinnesorgane, 61:161-265, 1912) classical distinction between beta (object) and phi (objectless) motion is elaborated here in a series of experiments concerning competition between two qualitatively different motion percepts, induced by sequential changes in luminance for two-dimensional geometric objects composed of rectangular surfaces. One of these percepts is of spreading-luminance motion that continuously sweeps across the entire object; it exhibits shape invariance and is perceived most strongly for fast speeds. Significantly for the characterization of phi as objectless motion, the spreading luminance does not involve surface boundaries or any other feature; the percept is driven solely by spatiotemporal changes in luminance. Alternatively, and for relatively slow speeds, a discrete series of edge motions can be perceived in the direction opposite to spreading-luminance motion. Akin to beta motion, the edges appear to move through intermediate positions within the object's changing surfaces. Significantly for the characterization of beta as object motion, edge motion exhibits shape dependence and is based on the detection of oppositely signed changes in contrast (i.e., counterchange) for features essential to the determination of an object's shape, the boundaries separating its surfaces. These results are consistent with area MT neurons that differ with respect to speed preference Newsome et al (Journal of Neurophysiology, 55:1340-1351, 1986) and shape dependence Zeki (Journal of Physiology, 236:549-573, 1974).

Automated continuous quantitative measurement of proximal airways on dynamic ventilation CT: initial experience using an ex vivo porcine lung phantom.

PubMed

Yamashiro, Tsuneo; Tsubakimoto, Maho; Nagatani, Yukihiro; Moriya, Hiroshi; Sakuma, Kotaro; Tsukagoshi, Shinsuke; Inokawa, Hiroyasu; Kimoto, Tatsuya; Teramoto, Ryuichi; Murayama, Sadayuki

2015-01-01

The purpose of this study was to evaluate the feasibility of continuous quantitative measurement of the proximal airways, using dynamic ventilation computed tomography (CT) and our research software. A porcine lung that was removed during meat processing was ventilated inside a chest phantom by a negative pressure cylinder (eight times per minute). This chest phantom with imitated respiratory movement was scanned by a 320-row area-detector CT scanner for approximately 9 seconds as dynamic ventilatory scanning. Obtained volume data were reconstructed every 0.35 seconds (total 8.4 seconds with 24 frames) as three-dimensional images and stored in our research software. The software automatically traced a designated airway point in all frames and measured the cross-sectional luminal area and wall area percent (WA%). The cross-sectional luminal area and WA% of the trachea and right main bronchus (RMB) were measured for this study. Two radiologists evaluated the traceability of all measurable airway points of the trachea and RMB using a three-point scale. It was judged that the software satisfactorily traced airway points throughout the dynamic ventilation CT (mean score, 2.64 at the trachea and 2.84 at the RMB). From the maximum inspiratory frame to the maximum expiratory frame, the cross-sectional luminal area of the trachea decreased 17.7% and that of the RMB 29.0%, whereas the WA% of the trachea increased 6.6% and that of the RMB 11.1%. It is feasible to measure airway dimensions automatically at designated points on dynamic ventilation CT using research software. This technique can be applied to various airway and obstructive diseases.

Decreased Neointimal Extracellular Matrix Formation in RAGE-Knockout Mice After Microvascular Denudation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Groezinger, Gerd, E-mail: gerd.groezinger@med.uni-tuebingen.de; Schmehl, Joerg, E-mail: joerg.schmehl@med.uni-tuebingen.de; Bantleon, Ruediger, E-mail: ruediger.bantleon@med.uni-tuebingen.de

2012-12-15

Purpose: To evaluate in vivo the role of RAGE (receptor for advanced glycated end products) in the development of restenosis and neointimal proliferation in RAGE-deficient knockout (KO) mice compared with wild-type (WT) mice in an animal model. Materials and Methods: Sixteen WT and 15 RAGE-deficient mice underwent microvascular denudation of the common femoral artery under general anaesthesia. Contralateral arteries underwent a sham operation and served as controls. Four weeks after the intervention, all animals were killed, and paraformaldehyde-fixed specimens of the femoral artery were analysed with different stains (hematoxylin and eosin and Elastica van Gieson) and several different types ofmore » immunostaining (proliferating cell nuclear antigen, {alpha}-actin, collagen, von Willebrand factor, RAGE). Luminal area, area of the neointima, and area of the media were measured in all specimens. In addition, colony-formation assays were performed, and collagen production by WT smooth muscle cells (SMCs) and RAGE-KO SMCs was determined. For statistical analysis, P < 0.05 was considered statistically significant. Results: Four weeks after denudation, WT mice showed a 49.6% loss of luminal area compared with 14.9% loss of luminal area in RAGE-deficient mice (sham = 0% loss) (P < 0.001). The neointima was 18.2 (*1000 {mu}m{sup 2} [n = 15) in the WT group compared with only 8.4 (*1000 {mu}m{sup 2} [n = 16]) in the RAGE-KO group. RAGE-KO SMCs showed significantly decreased proliferation activity and production of extracellular matrix protein. Conclusion: RAGE may be shown to play a considerable role in the formation of neointima leading to restenosis after vascular injury.« less

Exploration of the psychophysics of a motion displacement hyperacuity stimulus.

PubMed

Verdon-Roe, Gay Mary; Westcott, Mark C; Viswanathan, Ananth C; Fitzke, Frederick W; Garway-Heath, David F

2006-11-01

To explore the summation properties of a motion-displacement hyperacuity stimulus with respect to stimulus area and luminance, with the goal of applying the results to the development of a motion-displacement test (MDT) for the detection of early glaucoma. A computer-generated line stimulus was presented with displacements randomized between 0 and 40 minutes of arc (min arc). Displacement thresholds (50% seen) were compared for stimuli of equal area but different edge length (orthogonal to the direction of motion) at four retinal locations. Also, MDT thresholds were recorded at five values of Michelson contrast (25%-84%) for each of five line lengths (11-128 min arc) at a single nasal location (-27,3). Frequency-of-seeing (FOS) curves were generated and displacement thresholds and interquartile ranges (IQR, 25%-75% seen) determined by probit analysis. Equivalent displacement thresholds were found for stimuli of equal area but half the edge length. Elevations of thresholds and IQR were demonstrated as line length and contrast were reduced. Equivalent displacement thresholds were also found for stimuli of equivalent energy (stimulus area x [stimulus luminance - background luminance]), in accordance with Ricco's law. There was a linear relationship (slope -0.5) between log MDT threshold and log stimulus energy. Stimulus area, rather than edge length, determined displacement thresholds within the experimental conditions tested. MDT thresholds are linearly related to the square root of the total energy of the stimulus. A new law, the threshold energy-displacement (TED) law, is proposed to apply to MDT summation properties, giving the relationship T = K logE where, T is the MDT threshold, Kis the constant, and E is the stimulus energy.

The Hessdalen Luminous Phenomenon: A Data Analysis

NASA Astrophysics Data System (ADS)

Teodorani, M.; Strand, E. P.

1998-08-01

In the period 21 January - 26 February 1984, a group of research engineers belonging to "Project Hessdalen", carried out instrumental investigations on a luminous atmospheric phenomenon occurring with strong recurrence in the area of Hessdalen in Norway. Several multi-mode instruments were used in order to monitor the phenomenon. In the present work, an analytical attempt, based on the data achieved during the 1984 investigation period, has been done in order to explain such a phenomenon. The following main results are presented: (1) the luminous phenomenon occurs with a periodicity of about one day and is approximately coincident with some peculiar magnetic pulsations and, more scarcely, with some components of radio emission; (2) magnetometric data, radar data and some components of radiometric data show some slight correlation with daily solar activity. Hypothesis regarding formation of solar-driven plasmoids acquiring self-governing EM and magnetic fields, is further ventured and discussed. Technical requirements for future instrumental research are presented as well.

Illuminant-adaptive color reproduction for mobile display

NASA Astrophysics Data System (ADS)

Kim, Jong-Man; Park, Kee-Hyon; Kwon, Oh-Seol; Cho, Yang-Ho; Ha, Yeong-Ho

2006-01-01

This paper proposes an illuminant-adaptive reproduction method using light adaptation and flare conditions for a mobile display. Mobile displays, such as PDAs and cellular phones, are viewed under various lighting conditions. In particular, images displayed in daylight are perceived as quite dark due to the light adaptation of the human visual system, as the luminance of a mobile display is considerably lower than that of an outdoor environment. In addition, flare phenomena decrease the color gamut of a mobile display by increasing the luminance of dark areas and de-saturating the chroma. Therefore, this paper presents an enhancement method composed of lightness enhancement and chroma compensation. First, the ambient light intensity is measured using a lux-sensor, then the flare is calculated based on the reflection ratio of the display device and the ambient light intensity. The relative cone response is nonlinear to the input luminance. This is also changed by the ambient light intensity. Thus, to improve the perceived image, the displayed luminance is enhanced by lightness linearization. In this paper, the image's luminance is transformed by linearization of the response to the input luminance according to the ambient light intensity. Next, the displayed image is compensated according to the physically reduced chroma, resulting from flare phenomena. The reduced chroma value is calculated according to the flare for each intensity. The chroma compensation method to maintain the original image's chroma is applied differently for each hue plane, as the flare affects each hue plane differently. At this time, the enhanced chroma also considers the gamut boundary. Based on experimental observations, the outer luminance-intensity generally ranges from 1,000 lux to 30,000 lux. Thus, in the case of an outdoor environment, i.e. greater than 1,000 lux, this study presents a color reproduction method based on an inverse cone response curve and flare condition. Consequently, the proposed algorithm improves the quality of the perceived image adaptive to an outdoor environment.

Asymmetric effects of luminance and chrominance in the watercolor illusion

PubMed Central

Coia, Andrew J.; Crognale, Michael A.

2014-01-01

When bounded by a line of sufficient contrast, the desaturated hue of a colored line will spread over an enclosed area, an effect known as the watercolor illusion. The contrast of the two lines can be in luminance, chromaticity, or a combination of both. The effect is most salient when the enclosing line has greater contrast with the background than the line that induces the spreading color. In most prior experiments with watercolor spreading, the luminance of both lines has been lower than the background. An achromatic version of the illusion exists where a dark line will spread while being bounded by either a darker or brighter line. In a previous study we measured the strength of the watercolor effect in which the colored inducing line was isoluminant to the background, and found an illusion for both brighter and darker achromatic outer contours. We also found the strength of spreading is stronger for bluish (+S cone input) colors compared to yellowish (−S cone input) ones, when bounded by a dark line. The current study set out to measure the hue dependence of the watercolor illusion when inducing colors are flanked with brighter (increment) as opposed to darker outer lines. The asymmetry in the watercolor effect with S cone input was enhanced when the inducing contrast was an increment rather than a decrement. Further experiments explored the relationship between the perceived contrast of these chromatic lines when paired with luminance increments and decrements and revealed that the perceived contrast of luminance increments and decrements is dependent on which isoluminant color they are paired with. In addition to known hue asymmetries in the watercolor illusion there are asymmetries between luminance increments and decrements that are also hue dependent. These latter asymmetries may be related to the perceived contrast of the hue/luminance parings. PMID:25309396

Mechanism of lumen gain with a novel rotational aspiration atherectomy system for peripheral arterial disease: examination by intravascular ultrasound.

PubMed

Hassan, Ali H M; Ako, Junya; Waseda, Katsuhisa; Honda, Yasuhiro; Zeller, Thomas; Leon, Martin B; Fitzgerald, Peter J

2010-01-01

The purpose of this study was to evaluate the mechanism of luminal gain with a novel atheroablation system (Pathway PV) for the treatment of peripheral artery disease using intravascular ultrasound (IVUS). The atherectomy system is a rotational atherectomy device, which employs expandable rotating blades with ports that allow flushing and aspiration of the plaque material or thrombus. In this first-in-man clinical study, IVUS analysis was available in 6 patients with lower limb ischemia treated with this device. The treatment results were assessed using IVUS at pre and post atherectomy. Lumen beyond burr size (LBB) was defined as lumen gain divided by the estimated burr area determined by the burr-size. IVUS analysis was available in six patients (superficial femoral artery n=3, popliteal artery n=2, posterior tibial artery n=1). Atheroablation achieved a significant increase in lumen area (LA) (preintervention 3.9+/-0.4, postatheroablation 8.0+/-1.7 mm(2), P<.05), and significant reduction in plaque area (27.5+/-4.0, 23.7+/-3.1 mm(2), P=.001), while there was no change in the vessel area (31.3+/-4.2, 32.1+/-2.8 mm(2), P=.4). LBB was 57.4+/-51.3%. This novel rotational aspiration atherectomy device achieved significant luminal gain by debulking in the absence of vessel stretching. The LA was greater than burr-sized lumen expectancy at cross-sections along the treated segments, suggesting a complimentary role of aspiration in luminal gain in atherosclerotic peripheral artery lesions.

Vascular Assessment for Transcatheter Aortic Valve Replacement: Intravascular Ultrasound Compared With Computed Tomography.

PubMed

Essa, Essa; Makki, Nader; Bittenbender, Peter; Capers, Quinn; George, Barry; Rushing, Gregory; Crestanello, Juan; Boudoulas, Konstantinos Dean; Lilly, Scott M

2016-12-01

Assessment of the femoral and iliac arteries is essential prior to transcatheter aortic valve replacement (TAVR). It is critical for establishing candidacy for a femoral approach, and can help predict vascular complications. Although computed tomography angiography (CTA) is the standard imaging modality, it has limitations. This study compared CTA with intravascular ultrasound (IVUS) in patients undergoing TAVR evaluation. Fifteen patients undergoing pre-TAVR coronary angiography and hemodynamic assessment were recruited. Following coronary angiography, patients underwent distal aortography, bilateral iliac and femoral arteriography, and IVUS assessment. Vascular tortuosity, minimum lumen diameter, and cross-sectional area were obtained and the findings were compared with those obtained from CTA. Correlation between IVUS and CTA was strong for minimum luminal diameter (r=0.62). Concordance was also strong between CTA and invasive iliofemoral angiography for assessment of tortuosity (r=0.75). Utilizing Bland-Altman analysis, vessel diameters obtained by IVUS were consistently greater than those obtained by CTA. The angiography and IVUS strategy was associated with a lower overall mean contrast utilization (29 cc vs 100 cc; P<.001), reduced mean radiation exposure (527 mGy vs 998 mGy; P=.045), and no significant difference in mean test duration (13.3 minutes vs 10 minutes; P=.12). For femoral and iliac arterial assessment prior to TAVR, IVUS is a viable alternative to CTA with comparable accuracy, and the potential for less contrast use and less radiation exposure. IVUS is also a valuable adjunct to CTA in patients with borderline femoral access diameters or considerable CTA artifacts.

Radiation properties of two types of luminous textile devices containing plastic optical fibers

NASA Astrophysics Data System (ADS)

Selm, Bärbel; Rothmaier, Markus

2007-05-01

Luminous textiles have the potential to satisfy a need for thin and flexible light diffusers for treatment of intraoral cancerous tissue. Plastic optical fibers (POF) with diameters of 250 microns and smaller are used to make the textiles luminous. Usually light is supplied to the optical fiber at both ends. On the textile surface light emission occurs in a woven structure via damaged straight POFs, whereas the embroidered structure radiates the light out of macroscopically bent POFs. We compared the optical properties of these two types of textile diffusers using red light laser for the embroidery and light emitting diode (LED) for the woven structure as light sources, and found efficiencies for the luminous areas of the two samples of 19 % (woven) and 32 % (embroidery), respectively. It was shown that the efficiency can be greatly improved using an aluminium backing. Additional scattering layers lower the fluence rate by around 30 %. To analyse the homogeneity we took a photo of the illuminated surface using a 3CCD camera and found, for both textiles, a slightly skewed distribution of the dark and bright pixels. The interquartile range of brightness distribution of the embroidery is more than double as the woven structure.

Near-infrared imaging of CfA Seyfert galaxies

NASA Astrophysics Data System (ADS)

McLeod, K. K.; Rieke, G. H.

1995-03-01

We present near-IR images of 43 Seyfert galaxies from the CfA Seyfert sample. The near-IR luminosity is a good tracer of luminous mass in these galaxies. Most of the Seyfert nuclei are found in hosts of mass similar to that of L* galaxies and ranging in type from S0 to Sc. In addition, there is a population of low-mass host galaxies with very low luminosity Seyfert nuclei. We have examined our images for signs of perturbations that could drive fuel toward the galaxy nucleus, but there are none we can identify at a significant level. The critical element for fueling is evidently not reflected clearly in the large-scale distribution of luminous mass in the galaxy. The Seyfert hosts are compared with a sample of 50 low-redshift quasar host galaxies we have also imaged. The radio-quiet quasars and the Seyfert nuclei lie in similar kinds of galaxies spanning the same range of mass centered around L*. However, for the most luminous quasars, there is a correlation between the minimum host-galaxy mass and the luminosity of the active nucleus. Radio-loud quasars are generally found in hosts more massive than an L* galaxy. The low-luminosity quasars and the Seyfert nuclei both tend to lie in host galaxies seen preferentially face-on, which suggests that there is a substantial amount of obscuration coplanar with the galaxian disk. The obscuration must be geometrically thick (thickness-to-radius ratio approximately 1) and must cover a significant fraction of the narrow-line region (r greater than 100 pc).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Annis, J.

The collapse of a stellar core is expected to produce gravitational waves (GWs), neutrinos, and in most cases a luminous supernova. Sometimes, however, the optical event could be significantly less luminous than a supernova and a direct collapse to a black hole, where the star just disappears, is possible. The GW event GW150914 was detected by the LIGO Virgo Collaboration via a burst analysis that gave localization contours enclosing the Large Magellanic Cloud (LMC). Shortly thereafter, we used DECam to observe 102 deg 2 of the localization area, including 38 deg 2 on the LMC for a missing supergiant search.more » We construct a complete catalog of LMC luminous red supergiants, the best candidates to undergo invisible core collapse, and collected catalogs of other candidates: less luminous red supergiants, yellow supergiants, blue supergiants, luminous blue variable stars, and Wolf–Rayet stars. Of the objects in the imaging region, all are recovered in the images. The timescale for stellar disappearance is set by the free-fall time, which is a function of the stellar radius. Our observations at 4 and 13 days after the event result in a search sensitive to objects of up to about 200 solar radii. We conclude that it is unlikely that GW150914 was caused by the core collapse of a relatively compact supergiant in the LMC, consistent with the LIGO Collaboration analyses of the gravitational waveform as best interpreted as a high mass binary black hole merger. Lastly, we discuss how to generalize this search for future very nearby core-collapse candidates.« less

Luminance- and Texture-Defined Information Processing in School-Aged Children with Autism

PubMed Central

Rivest, Jessica B.; Jemel, Boutheina; Bertone, Armando; McKerral, Michelle; Mottron, Laurent

2013-01-01

According to the complexity-specific hypothesis, the efficacy with which individuals with autism spectrum disorder (ASD) process visual information varies according to the extensiveness of the neural network required to process stimuli. Specifically, adults with ASD are less sensitive to texture-defined (or second-order) information, which necessitates the implication of several cortical visual areas. Conversely, the sensitivity to simple, luminance-defined (or first-order) information, which mainly relies on primary visual cortex (V1) activity, has been found to be either superior (static material) or intact (dynamic material) in ASD. It is currently unknown if these autistic perceptual alterations are present in childhood. In the present study, behavioural (threshold) and electrophysiological measures were obtained for static luminance- and texture-defined gratings presented to school-aged children with ASD and compared to those of typically developing children. Our behavioural and electrophysiological (P140) results indicate that luminance processing is likely unremarkable in autistic children. With respect to texture processing, there was no significant threshold difference between groups. However, unlike typical children, autistic children did not show reliable enhancements of brain activity (N230 and P340) in response to texture-defined gratings relative to luminance-defined gratings. This suggests reduced efficiency of neuro-integrative mechanisms operating at a perceptual level in autism. These results are in line with the idea that visual atypicalities mediated by intermediate-scale neural networks emerge before or during the school-age period in autism. PMID:24205355

Luminance- and texture-defined information processing in school-aged children with autism.

PubMed

Rivest, Jessica B; Jemel, Boutheina; Bertone, Armando; McKerral, Michelle; Mottron, Laurent

2013-01-01

According to the complexity-specific hypothesis, the efficacy with which individuals with autism spectrum disorder (ASD) process visual information varies according to the extensiveness of the neural network required to process stimuli. Specifically, adults with ASD are less sensitive to texture-defined (or second-order) information, which necessitates the implication of several cortical visual areas. Conversely, the sensitivity to simple, luminance-defined (or first-order) information, which mainly relies on primary visual cortex (V1) activity, has been found to be either superior (static material) or intact (dynamic material) in ASD. It is currently unknown if these autistic perceptual alterations are present in childhood. In the present study, behavioural (threshold) and electrophysiological measures were obtained for static luminance- and texture-defined gratings presented to school-aged children with ASD and compared to those of typically developing children. Our behavioural and electrophysiological (P140) results indicate that luminance processing is likely unremarkable in autistic children. With respect to texture processing, there was no significant threshold difference between groups. However, unlike typical children, autistic children did not show reliable enhancements of brain activity (N230 and P340) in response to texture-defined gratings relative to luminance-defined gratings. This suggests reduced efficiency of neuro-integrative mechanisms operating at a perceptual level in autism. These results are in line with the idea that visual atypicalities mediated by intermediate-scale neural networks emerge before or during the school-age period in autism.

Measured daylighting potential of a static optical louver system under real sun and sky conditions

DOE PAGES

Konis, Kyle; Lee, Eleanor S.

2015-05-04

Side-by-side comparisons were made over solstice-to-solstice changes in sun and sky conditions between an optical louver system (OLS) and a conventional Venetian blind set at a horizontal slat angle and located inboard of a south-facing, small-area, clerestory window in a full-scale office testbed. Daylight autonomy (DA), window luminance, and ceiling luminance uniformity were used to assess performance. The performance of both systems was found to have significant seasonal variation, where performance under clear sky conditions improved as maximum solar altitude angles transitioned from solstice to equinox. Although the OLS produced fewer hours per day of DA on average than themore » Venetian blind, the OLS never exceeded the designated 2000 cd/m2 threshold for window glare. In contrast, the Venetian blind was found to exceed the visual discomfort threshold over a large fraction of the day during equinox conditions. Notably, these peak periods of visual discomfort occurred during the best periods of daylighting performance. Luminance uniformity was analyzed using calibrated high dynamic range luminance images. Under clear sky conditions, the OLS was found to increase the luminance of the ceiling as well as produce a more uniform distribution. Furthermore, compared to conventional venetian blinds, the static optical sunlight redirecting system studied has the potential to significantly reduce the annual electrical lighting energy demand of a daylit space and improve the quality from the perspective of building occupants by consistently transmitting useful daylight while eliminating window glare.« less

Assessing Visual Delays using Pupil Oscillations

NASA Technical Reports Server (NTRS)

Mulligan, Jeffrey B.

2012-01-01

Stark (1962) demonstrated vigorous pupil oscillations by illuminating the retina with a beam of light focussed to a small spot near the edge of the pupil. Small constrictions of the pupil then are sufficient to completely block the beam, amplifying the normal relationship between pupil area and retinal illuminance. In addition to this simple and elegant method, Stark also investigated more complex feedback systems using an electronic "clamping box" which provided arbitrary gain and phase delay between a measurement of pupil area and an electronically controlled light source. We have replicated Stark's results using a video-based pupillometer to control the luminance of a display monitor. Pupil oscillations were induced by imposing a linear relationship between pupil area and display luminance, with a variable delay. Slopes of the period-vs-delay function for 3 subjects are close to the predicted value of 2 (1.96-2.39), and the implied delays range from 254 to 376 508 to 652 milliseconds. Our setup allows us to extend Stark's work by investigating a broader class of stimuli.

The specificity of cortical region KO to depth structure.

PubMed

Tyler, Christopher W; Likova, Lora T; Kontsevich, Leonid L; Wade, Alex R

2006-03-01

Functional MRI studies have identified a cortical region designated as KO between retinotopic areas V3A/B and motion area V5 in human cortex as particularly responsive to motion-defined or kinetic borders. To determine the response of the KO region to more general aspects of structure, we used stereoscopic depth borders and disparate planes with no borders, together with three stimulus types that evoked no depth percept: luminance borders, line contours and illusory phase borders. Responses to these stimuli in the KO region were compared with the responses in retinotopically defined areas that have been variously associated with disparity processing in neurophysiological and fMRI studies. The strongest responses in the KO region were to stimuli evoking perceived depth structure from either disparity or motion cues, but it showed negligible responses either to luminance-based contour stimuli or to edgeless disparity stimuli. We conclude that the region designated as KO is best regarded as a primary center for the generic representation of depth structure rather than any kind of contour specificity.

Psychophysical Calibration of Mobile Touch-Screens for Vision Testing in the Field

NASA Technical Reports Server (NTRS)

Mulligan, Jeffrey B.

2015-01-01

The now ubiquitous nature of touch-screen displays in cell phones and tablet computers makes them an attractive option for vision testing outside of the laboratory or clinic. Accurate measurement of parameters such as contrast sensitivity, however, requires precise control of absolute and relative screen luminances. The nonlinearity of the display response (gamma) can be measured or checked using a minimum motion technique similar to that developed by Anstis and Cavanagh (1983) for the determination of isoluminance. While the relative luminances of the color primaries vary between subjects (due to factors such as individual differences in pre-retinal pigment densities), the gamma nonlinearity can be checked in the lab using a photometer. Here we compare results obtained using the psychophysical method with physical measurements for a number of different devices. In addition, we present a novel physical method using the device's built-in front-facing camera in conjunction with a mirror to jointly calibrate the camera and display. A high degree of consistency between devices is found, but some departures from ideal performance are observed. In spite of this, the effects of calibration errors and display artifacts on estimates of contrast sensitivity are found to be small.

Regional peculiarities in the inter-annual distribution of the red 630.0 nm line nightglow intensities over Abastumani

NASA Astrophysics Data System (ADS)

Toriashvili, L.; Didebulidze, G. G.; Todua, M.

2017-12-01

Peculiarities of the inter-annual distribution of atomic oxygen red OI 630.0 nm line nightglow intensity observed from Abastumani Astrophysical Observatory (41.75 N; 42.82 E) are considered, using the long-term dataset. This distribution demonstrates semi-annual and annual-like variations which occur during solar minimum, as well as maximum phases. The maximum values of the red line intensities are in Summer, however in June it is lower than in May and July, which may be due to regional effects. This phenomenon is considered as a the possible result of regional dynamical processes influencing the behavior of the ionosphere F2 layer which cause changes of electrons/ions densities in the 630.0 nm line luminous region (maximum luminous layer is at about 230-280 km). Using the red line intensities and ionosphere F2 layer electron density data of the IRI-12 model, the changes of meridional thermospheric wind velocities are estimated for this mid-latitude region. These meridional and vertical wind field changes causes of variations of the red line intensities in June can be caused by tidal wind and accompanied by atmospheric gravity waves activities.

Perceptual distortion analysis of color image VQ-based coding

NASA Astrophysics Data System (ADS)

Charrier, Christophe; Knoblauch, Kenneth; Cherifi, Hocine

1997-04-01

It is generally accepted that a RGB color image can be easily encoded by using a gray-scale compression technique on each of the three color planes. Such an approach, however, fails to take into account correlations existing between color planes and perceptual factors. We evaluated several linear and non-linear color spaces, some introduced by the CIE, compressed with the vector quantization technique for minimum perceptual distortion. To study these distortions, we measured contrast and luminance of the video framebuffer, to precisely control color. We then obtained psychophysical judgements to measure how well these methods work to minimize perceptual distortion in a variety of color space.

Time course of discrimination between emotional facial expressions: the role of visual saliency.

PubMed

Calvo, Manuel G; Nummenmaa, Lauri

2011-08-01

Saccadic and manual responses were used to investigate the speed of discrimination between happy and non-happy facial expressions in two-alternative-forced-choice tasks. The minimum latencies of correct saccadic responses indicated that the earliest time point at which discrimination occurred ranged between 200 and 280ms, depending on type of expression. Corresponding minimum latencies for manual responses ranged between 440 and 500ms. For both response modalities, visual saliency of the mouth region was a critical factor in facilitating discrimination: The more salient the mouth was in happy face targets in comparison with non-happy distracters, the faster discrimination was. Global image characteristics (e.g., luminance) and semantic factors (i.e., categorical similarity and affective valence of expression) made minor or no contribution to discrimination efficiency. This suggests that visual saliency of distinctive facial features, rather than the significance of expression, is used to make both early and later expression discrimination decisions. Copyright © 2011 Elsevier Ltd. All rights reserved.

Novel Strategy for Temporary Decompression of the Lower Urinary Tract in Neonates Using a Ureteral Stent.

PubMed

Penna, Frank J; Bowlin, Paul; Alyami, Fahad; Bägli, Darius J; Koyle, Martin A; Lorenzo, Armando J

2015-10-01

In children with congenital obstructive uropathy, including posterior urethral valves, lower urinary tract decompression is recommended pending definitive surgical intervention. Current options, which are limited to a feeding tube or Foley catheter, pose unappreciated constraints in luminal diameter and are associated with potential problems. We assess the impact of luminal diameter on the current draining options and present a novel alternative method, repurposing a widely available stent that optimizes drainage. We retrospectively reviewed patients diagnosed with posterior urethral valves between January 2013 and December 2014. In all patients a 6Fr 12 cm Double-J ureteral stent was advanced over a guidewire in a retrograde fashion into the bladder. Luminal flow and cross-sectional areas were also assessed for each of 3 tubes for urinary drainage, ie 6Fr Double-J stent, 5Fr feeding tube and 6Fr Foley catheter. A total of 30 patients underwent uneventful bedside Double-J stent placement. Mean ± SD age at valve ablation was 28.5 ± 16.6 days. Mean ± SD peak serum creatinine was 2.23 ± 0.97 mg/dl after birth and 0.56 ± 0.22 mg/dl at the procedure. Urine output after stent placement was excellent in all patients. The Foley catheter and feeding tube drained approximately 18 and 6 times more slowly, respectively, and exhibited half the calculated cross-sectional luminal area compared to the Double-J stent. Use of Double-J stents in neonates with posterior urethral valves is a safe and effective alternative method for lower urinary tract decompression that optimizes the flow/lumen relationship compared to conventional drainage options. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Brightness and transparency in the early visual cortex.

PubMed

Salmela, Viljami R; Vanni, Simo

2013-06-24

Several psychophysical studies have shown that transparency can have drastic effects on brightness and lightness. However, the neural processes generating these effects have remained unresolved. Several lines of evidence suggest that the early visual cortex is important for brightness perception. While single cell recordings suggest that surface brightness is represented in the primary visual cortex, the results of functional magnetic resonance imaging (fMRI) studies have been discrepant. In addition, the location of the neural representation of transparency is not yet known. We investigated whether the fMRI responses in areas V1, V2, and V3 correlate with brightness and transparency. To dissociate the blood oxygen level-dependent (BOLD) response to brightness from the response to local border contrast and mean luminance, we used variants of White's brightness illusion, both opaque and transparent, in which luminance increments and decrements cancel each other out. The stimuli consisted of a target surface and a surround. The surround luminance was always sinusoidally modulated at 0.5 Hz to induce brightness modulation to the target. The target luminance was constant or modulated in counterphase to null brightness modulation. The mean signal changes were calculated from the voxels in V1, V2, and V3 corresponding to the retinotopic location of the target surface. The BOLD responses were significantly stronger for modulating brightness than for stimuli with constant brightness. In addition, the responses were stronger for transparent than for opaque stimuli, but there was more individual variation. No interaction between brightness and transparency was found. The results show that the early visual areas V1-V3 are sensitive to surface brightness and transparency and suggest that brightness and transparency are represented separately.

Orientation-specific contextual modulation of the fMRI BOLD response to luminance and chromatic gratings in human visual cortex.

PubMed

McDonald, J Scott; Seymour, Kiley J; Schira, Mark M; Spehar, Branka; Clifford, Colin W G

2009-05-01

The responses of orientation-selective neurons in primate visual cortex can be profoundly affected by the presence and orientation of stimuli falling outside the classical receptive field. Our perception of the orientation of a line or grating also depends upon the context in which it is presented. For example, the perceived orientation of a grating embedded in a surround tends to be repelled from the predominant orientation of the surround. Here, we used fMRI to investigate the basis of orientation-specific surround effects in five functionally-defined regions of visual cortex: V1, V2, V3, V3A/LO1 and hV4. Test stimuli were luminance-modulated and isoluminant gratings that produced responses similar in magnitude. Less BOLD activation was evident in response to gratings with parallel versus orthogonal surrounds across all the regions of visual cortex investigated. When an isoluminant test grating was surrounded by a luminance-modulated inducer, the degree of orientation-specific contextual modulation was no larger for extrastriate areas than for V1, suggesting that the observed effects might originate entirely in V1. However, more orientation-specific modulation was evident in extrastriate cortex when both test and inducer were luminance-modulated gratings than when the test was isoluminant; this difference was significant in area V3. We suggest that the pattern of results in extrastriate cortex may reflect a refinement of the orientation-selectivity of surround suppression specific to the colour of the surround or, alternatively, processes underlying the segmentation of test and inducer by spatial phase or orientation when no colour cue is available.

Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells.

PubMed

Cereser, Biancastella; Jansen, Marnix; Austin, Emily; Elia, George; McFarlane, Taneisha; van Deurzen, Carolien Hm; Sieuwerts, Anieta M; Daidone, Maria G; Tadrous, Paul J; Wright, Nicholas A; Jones, Louise; McDonald, Stuart Ac

2018-01-01

It is widely accepted that the cell of origin of breast cancer is the adult mammary epithelial stem cell; however, demonstrating the presence and location of tissue stem cells in the human breast has proved difficult. Furthermore, we do not know the clonal architecture of the normal and premalignant mammary epithelium or its cellular hierarchy. Here, we use deficiency in the mitochondrial enzyme cytochrome c oxidase (CCO), typically caused by somatic mutations in the mitochondrial genome, as a means to perform lineage tracing in the human mammary epithelium. PCR sequencing of laser-capture microdissected cells in combination with immunohistochemistry for markers of lineage differentiation was performed to determine the clonal nature of the mammary epithelium. We have shown that in the normal human breast, clonal expansions (defined here by areas of CCO deficiency) are typically uncommon and of limited size, but can occur at any site within the adult mammary epithelium. The presence of a stem cell population was shown by demonstrating multi-lineage differentiation within CCO-deficient areas. Interestingly, we observed infrequent CCO deficiency that was restricted to luminal cells, suggesting that niche succession, and by inference stem cell location, is located within the luminal layer. CCO-deficient areas appeared large within areas of ductal carcinoma in situ, suggesting that the rate of clonal expansion was altered in the premalignant lesion. © 2017 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. © 2017 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

Optimum display luminance depends on white luminance under various ambient illuminance conditions

NASA Astrophysics Data System (ADS)

Kim, Minkoo; Jeon, Dong-Hwan; Kim, Jeong-Sik; Yu, Byung-Chang; Park, YungKyung; Lee, Seung-Woo

2018-02-01

This paper reports display luminance levels for good visibility under nine ambient illuminance conditions (50, 100, 200, 500, 1000, 2000, 5000, 10,000, and 20,000 lx) for a given white luminance level, chosen from five candidates (100, 200, 500, 1000, and 2000 cd / m2), through a psychophysical experiment. This work reveals that the luminance levels for good visibility increase as the maximum white luminance of the display increases. The white luminance dependency of display luminance is caused by the fact that the human visual system adapts to the maximum white luminance and evaluates the brightness of the display based on it. Based on the experimental results, an appropriate luminance zone under various illuminance conditions is proposed. The appropriate luminance zone varies with the maximum white luminance of the displays. This may be understood to mean that there is no absolute luminance level under a given lighting condition. To solve this issue, a new method is proposed to determine optimum luminance levels by considering both visibility and power consumption. By the proposed method, it is reported that the optimum maximum luminance lies between 200 and 500 cd / m2 for indoor use (below 500 lx). These results were verified by young adults with normal vision.

Hybrid metal grid-polymer-carbon nanotube electrodes for high luminance organic light emitting diodes

NASA Astrophysics Data System (ADS)

Sam, F. Laurent M.; Dabera, G. Dinesha M. R.; Lai, Khue T.; Mills, Christopher A.; Rozanski, Lynn J.; Silva, S. Ravi P.

2014-08-01

Organic light emitting diodes (OLEDs) incorporating grid transparent conducting electrodes (TCEs) with wide grid line spacing suffer from an inability to transfer charge carriers across the gaps in the grids to promote light emission in these areas. High luminance OLEDs fabricated using a hybrid TCE composed of poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS PH1000) or regioregular poly(3-hexylthiophene)-wrapped semiconducting single-walled carbon nanotubes (rrP3HT-SWCNT) in combination with a nanometre thin gold grid are reported here. OLEDs fabricated using the hybrid gold grid/PH1000 TCE have a luminance of 18 000 cd m-2 at 9 V; the same as the reference indium tin oxide (ITO) OLED. The gold grid/rrP3HT-SWCNT OLEDs have a lower luminance of 8260 cd m-2 at 9 V, which is likely due to a rougher rrP3HT-SWCNT surface. These results demonstrate that the hybrid gold grid/PH1000 TCE is a promising replacement for ITO in future plastic electronics applications including OLEDs and organic photovoltaics. For applications where surface roughness is not critical, e.g. electrochromic devices or discharge of static electricity, the gold grid/rrP3HT-SWCNT hybrid TCE can be employed.

Basal-like Breast Cancers: From Pathology to Biology and Back Again.

PubMed

Gusterson, Barry; Eaves, Connie J

2018-06-05

Human breast cancers referred to as "basal-like" are of interest because they lack effective therapies and their biology is poorly understood. The term basal-like derives from studies demonstrating tumor gene expression profiles that include some transcripts characteristic of the basal cells of the normal adult human mammary gland and others associated with a subset of normal luminal cells. Elucidating the mechanisms responsible for the profiles of basal-like tumors is an active area of investigation. More refined molecular analysis of patients' samples and genetic strategies to produce breast cancers de novo from defined populations of normal mouse mammary cells have served as complementary approaches to identify relevant pathway alterations. However, both also have limitations. Here, we review some of the underlying reasons, including the unifying concept that some normal luminal cells have both luminal and basal features, as well as some emerging new avenues of investigation. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Morphometry of right ventricular hypertrophy induced by myocardial infarction in the rat.

PubMed Central

Anversa, P.; Beghi, C.; McDonald, S. L.; Levicky, V.; Kikkawa, Y.; Olivetti, G.

1984-01-01

The growth response of the right ventricle was studied in rats following ligation of the left coronary artery, which produced infarcts comprising approximately 40% of the left ventricle. A month after surgery the weight of the right ventricle was increased 30%, and this hypertrophic change was characterized by a 17% wall thickening, consistent with the 13% greater diameter of myocytes. Myocardial hypertrophy was accompanied by an inadequate growth of the microvasculature that supports tissue oxygenation. This was seen by relative decreases in capillary luminal volume density (-27%) and capillary luminal surface density (-21%) and by an increase in the average maximum distance from the capillary wall to the mitochondria of myocytes (19%). In contrast, measurements of the mean myocyte volume per nucleus showed a proportional enlargement of these cells (32%), from 16,300 cu mu in control animals to 21,500 cu mu in experimental rats. Quantitative analysis of the right coronary artery revealed a 33% increase in its luminal area, commensurate with the magnitude of ventricular hypertrophy. PMID:6236695

DOE Office of Scientific and Technical Information (OSTI.GOV)

Annis, J.; Soares-Santos, M.; Diehl, H. T.

The collapse of a stellar core is expected to produce gravitational waves (GWs), neutrinos, and in most cases a luminous supernova. Sometimes, however, the optical event could be significantly less luminous than a supernova and a direct collapse to a black hole, where the star just disappears, is possible. The GW event GW150914 was detected by the LIGO Virgo Collaboration via a burst analysis that gave localization contours enclosing the Large Magellanic Cloud (LMC). Shortly thereafter, we used DECam to observe 102 deg{sup 2} of the localization area, including 38 deg{sup 2} on the LMC for a missing supergiant search.more » We construct a complete catalog of LMC luminous red supergiants, the best candidates to undergo invisible core collapse, and collected catalogs of other candidates: less luminous red supergiants, yellow supergiants, blue supergiants, luminous blue variable stars, and Wolf–Rayet stars. Of the objects in the imaging region, all are recovered in the images. The timescale for stellar disappearance is set by the free-fall time, which is a function of the stellar radius. Our observations at 4 and 13 days after the event result in a search sensitive to objects of up to about 200 solar radii. We conclude that it is unlikely that GW150914 was caused by the core collapse of a relatively compact supergiant in the LMC, consistent with the LIGO Collaboration analyses of the gravitational waveform as best interpreted as a high mass binary black hole merger. We discuss how to generalize this search for future very nearby core-collapse candidates.« less

Light intensity of curved laryngoscope blades in Philadelphia emergency departments.

PubMed

Levitan, Richard M; Kelly, John J; Kinkle, William C; Fasano, Charles

2007-09-01

Laryngoscopy and tracheal intubation requires laryngeal exposure and illumination. The objective of this study is to assess variation in laryngoscope lights across different emergency departments (EDs). A convenience sample of 3 Mac #4 blade and handle pairs in each of 17 Philadelphia area EDs was tested with a digital light meter to derive the median lux at the distal tip. For each blade tested, we characterized blade design (American, English, or German) and light type (fiber-illuminated versus conventional bulb-on-blade) and measured light-to-tip distance. A total of 50 blades and handle pairs were tested (one ED had only 2 Mac #4 blades). American designs were the most common (38/50), followed by English (6/50) and German (3/50) designs. Three blades had hybrid design features and acrylic light-conducting fibers. Median luminance varied from 11 lux to 5,627 lux. The glass fiber-illuminated blades (n=13) produced greater luminance (median 1,205 lux; interquartile range [IQR] 726 to 2,176 lux) than bulb-on-blade designs (median 689 lux; IQR 290 to 906 lux). German fiber-illuminated blades produced the highest luminance (median 1,937 lux; IQR 1,453 to 3,782 lux). English bulb-on-blade designs produced more luminance (median 915 lux; IQR 745 to 1270 lux) than American (median 689 lux; IQR 269 to 807 lux). German and English blades had shorter light-to-tip distances (median 51 mm and 47 mm, respectively) than American blades (65 mm). Curved laryngoscope blades in different EDs have marked variation in light intensity. The contribution of luminance to laryngoscopy performance warrants investigation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sommer, C. M., E-mail: christof.sommer@med.uni-heidelberg.de; Grenacher, L.; Stampfl, U.

The purpose of this study was to evaluate the impact of stent design on in-stent stenosis in rabbit iliac arteries. Four different types of stent were implanted in rabbit iliac arteries, being different in stent design (crown or wave) and strut thickness (50 or 100 {mu}m). Ten stents of each type were implanted. Each animal received one crown and one wave stent with the same strut thickness. Follow-up was either 12 weeks (n = 10 rabbits) or 24 weeks (n = 10 rabbits). Primary study end points were angiographic and microscopic in-stent stenosis. Secondary study end points were vessel injury,more » vascular inflammation, and stent endothelialization. Average stent diameter, relative stent overdilation, average and minimal luminal diameter, and relative average and maximum luminal loss were not significantly different. However, a trend to higher relative stent overdilation was recognized in crown stents compared to wave stents. A trend toward higher average and minimal luminal diameter and lower relative average and maximum luminal loss was recognized in crown stents compared to wave stents with a strut thickness of 100 {mu}m. Neointimal height, relative luminal area stenosis, injury score, inflammation score, and endothelialization score were not significantly different. However, a trend toward higher neointimal height was recognized in crown stents compared to wave stents with a strut thickness of 50 {mu}m and a follow-up of 24 weeks. In conclusion, in this study, crown stents seem to trigger neointima. However, the optimized radial force might equalize the theoretically higher tendency for restenosis in crown stents. In this context, also more favorable positive remodeling in crown stents could be important.« less

A Dark Energy Camera Search for Missing Supergiants in the LMC After the Advanced LIGO Gravitational-Wave Event GW150914

NASA Technical Reports Server (NTRS)

Annis, J.; Soares-Santos, M.; Berger, E.; Brout, D.; Chen, H.; Chornock, R.; Cowperthwaite, P. S.; Diehl, H. T.; Doctor, Z.; Cenko, S. B.

2016-01-01

The collapse of a stellar core is expected to produce gravitational waves (GWs), neutrinos, and in most cases a luminous supernova. Sometimes, however, the optical event could be significantly less luminous than a supernova and a direct collapse to a black hole, where the star just disappears, is possible. The GW event GW150914 was detected by the LIGO Virgo Collaboration via a burst analysis that gave localization contours enclosing the Large Magellanic Cloud (LMC). Shortly thereafter, we used DECam to observe 102 deg(exp.2) of the localization area,including 38 deg(exp. 2) on the LMC for a missing supergiant search. We construct a complete catalog of LMC luminous red supergiants, the best candidates to undergo invisible core collapse, and collected catalogs of other candidates:less luminous red supergiants, yellow supergiants, blue supergiants, luminous blue variable stars, and Wolf-Rayet stars. Of the objects in the imaging region, all are recovered in the images. The timescale for stellar disappearance is set by the free-fall time, which is a function of the stellar radius. Our observations at 4 and 13 days after the event result in a search sensitive to objects of up to about 200 solar radii. We conclude that it is unlikely that GW150914 was caused by the core collapse of a relatively compact supergiant in the LMC, consistent with the LIGO Collaboration analyses of the gravitational waveform as best interpreted as a high mass binary black hole merger. We discuss how to generalize this search for future very nearby core-collapse candidates.

An Evaluation of Performance Characteristics of Primary Display Devices.

PubMed

Ekpo, Ernest U; McEntee, Mark F

2016-04-01

The aim of this study was to complete a full evaluation of the new EIZO RX850 liquid crystal display and compare it to two currently used medical displays in Australia (EIZO GS510 and Barco MDCG 5121). The American Association of Physicists in Medicine (AAPM) Task Group 18 Quality Control test pattern was used to assess the performance of three high-resolution primary medical displays: EIZO RX850, EIZO GS510, and Barco MDCG 5121. A Konica Minolta spectroradiometer (CS-2000) was used to assess luminance response, non-uniformity, veiling glare, and color uniformity. Qualitative evaluation of noise was also performed. Seven breast lesions were displayed on each monitor and photographed with a calibrated 5.5-MP Olympus E-1 digital SLR camera. ImageJ software was used to sample pixel information from each lesion and surrounding background to calculate their conspicuity index on each of the displays. All monitor fulfilled all AAPM acceptance criteria. The performance characteristics for EIZO RX850, Barco MDCG 5121, and EIZO GS510 respectively were as follows: maximum luminance (490, 500.5, and 413 cd/m(2)), minimum luminance (0.724, 1.170, and 0.92 cd/m(2)), contrast ratio (675:1, 428:1, 449:1), just-noticeable difference index (635, 622, 609), non-uniformity (20, 5.92, and 8.5 %), veiling glare (GR = 2465.6, 720.4, 1249.8), and color uniformity (Δu'v' = +0.003, +0.002, +0.002). All monitors demonstrated low noise levels. The conspicuity index (χ) of the lesions was slightly higher in the EIZO RX850 display. All medical displays fulfilled AAPM performance criteria, and performance characteristics of EIZO RX850 are equal to or better than those of the Barco MDCG 5121 and EIZO GS510 displays.

Testing the Triggering Mechanism for Luminous, Radio-Quiet Red Quasars in the Clearing Phase: A Comparison to Radio-Loud Red Quasars

NASA Astrophysics Data System (ADS)

Glikman, Eliat

2016-10-01

We propose to conduct a controlled study of the relationship between radio emission and host galaxy morphology for a new sample of radio-quiet dust-reddened quasars selected by their infrared colors in WISE and 2MASS (W2M). These sources are the radio-quiet analogs to the FIRST-2MASS (F2M) red quasars, which we found to be predominantly driven by major mergers. F2M red quasars are accreting at very high rates and exhibit broad absorption lines associated with outflows and feedback. Their properties are consistent with buried quasars expelling their dusty shrouds in an an evolutionary phase predicted by merger-driven co-evolution models. The quasars in both samples are the most intrinsically luminous objects in the Universe - the regime where we expect mergers to dominate. However, recent lines of evidence suggest that radio emission may be linked to AGN reddening and merging hosts. We will use WFC3/IR and ACS to image the host galaxies of W2M quasars in the two redshift regimes that our previous studies probed, z 0.7 and z 2, testing the merger-driven quasar paradigm across the full radio range with a minimum of selection effects or other biases that plague many studies comparing different samples. The images proposed here will sample the host galaxies in rest-frame visible and UV light to look for merger signatures. Evidence for mergers in these quasar hosts would support a picture in which luminous quasars and galaxies co-evolve through major-mergers, independent of their radio properties. The absence of mergers in our data would link radio emission to mergers and require an alternate explanation for the extreme properties of these radio-quiet sources.

Imaging acquisition display performance: an evaluation and discussion of performance metrics and procedures.

PubMed

Silosky, Michael S; Marsh, Rebecca M; Scherzinger, Ann L

2016-07-08

When The Joint Commission updated its Requirements for Diagnostic Imaging Services for hospitals and ambulatory care facilities on July 1, 2015, among the new requirements was an annual performance evaluation for acquisition workstation displays. The purpose of this work was to evaluate a large cohort of acquisition displays used in a clinical environment and compare the results with existing performance standards provided by the American College of Radiology (ACR) and the American Association of Physicists in Medicine (AAPM). Measurements of the minimum luminance, maximum luminance, and luminance uniformity, were performed on 42 acquisition displays across multiple imaging modalities. The mean values, standard deviations, and ranges were calculated for these metrics. Additionally, visual evaluations of contrast, spatial resolution, and distortion were performed using either the Society of Motion Pictures and Television Engineers test pattern or the TG-18-QC test pattern. Finally, an evaluation of local nonuniformities was performed using either a uniform white display or the TG-18-UN80 test pattern. Displays tested were flat panel, liquid crystal displays that ranged from less than 1 to up to 10 years of use and had been built by a wide variety of manufacturers. The mean values for Lmin and Lmax for the displays tested were 0.28 ± 0.13 cd/m2 and 135.07 ± 33.35 cd/m2, respectively. The mean maximum luminance deviation for both ultrasound and non-ultrasound displays was 12.61% ± 4.85% and 14.47% ± 5.36%, respectively. Visual evaluation of display performance varied depending on several factors including brightness and contrast settings and the test pattern used for image quality assessment. This work provides a snapshot of the performance of 42 acquisition displays across several imaging modalities in clinical use at a large medical center. Comparison with existing performance standards reveals that changes in display technology and the move from cathode ray tube displays to flat panel displays may have rendered some of the tests inappropriate for modern use. © 2016 The Authors.

Coherent Activity in Bilateral Parieto-Occipital Cortices during P300-BCI Operation.

PubMed

Takano, Kouji; Ora, Hiroki; Sekihara, Kensuke; Iwaki, Sunao; Kansaku, Kenji

2014-01-01

The visual P300 brain-computer interface (BCI), a popular system for electroencephalography (EEG)-based BCI, uses the P300 event-related potential to select an icon arranged in a flicker matrix. In earlier studies, we used green/blue (GB) luminance and chromatic changes in the P300-BCI system and reported that this luminance and chromatic flicker matrix was associated with better performance and greater subject comfort compared with the conventional white/gray (WG) luminance flicker matrix. To highlight areas involved in improved P300-BCI performance, we used simultaneous EEG-fMRI recordings and showed enhanced activities in bilateral and right lateralized parieto-occipital areas. Here, to capture coherent activities of the areas during P300-BCI, we collected whole-head 306-channel magnetoencephalography data. When comparing functional connectivity between the right and left parieto-occipital channels, significantly greater functional connectivity in the alpha band was observed under the GB flicker matrix condition than under the WG flicker matrix condition. Current sources were estimated with a narrow-band adaptive spatial filter, and mean imaginary coherence was computed in the alpha band. Significantly greater coherence was observed in the right posterior parietal cortex under the GB than under the WG condition. Re-analysis of previous EEG-based P300-BCI data showed significant correlations between the power of the coherence of the bilateral parieto-occipital cortices and their performance accuracy. These results suggest that coherent activity in the bilateral parieto-occipital cortices plays a significant role in effectively driving the P300-BCI.

Eta Carinae: Linelist for the Emission Spectrum of the Weigelt Blobs in the 1700-10400Angstrom Wavelength Region

NASA Technical Reports Server (NTRS)

Zethson, T.; Johansson, S.; Hartman, H.; Gull, T. R.

2011-01-01

Aims. We present line identifications in the 1700 to 10400A region for the Weigelt Blobs B and D, located 0.1 to 0.3" NNW of Eta Carinae. The aim of this work is to characterize the behavior of these luminous, dense gas condensations in response to the broad maximum and short minimum states of Eta Carinae during its 5.54-year spectroscopic period. Methods. The observations were carried out during March 1998, the minimum spectrum, and in February 1999, early maximum spectrum, with the Hubble Space Telescope/Space Telescope Imaging Spectrograph (HST/STIS) from 1640 to 10400A using the 52"x0.1" aperture centered on Eta Carinae at position angle -28 degrees. Extractions of the reduced spectrum centered on Weigelt B and D, 0.28: in length along the slit, were used to identify the narrow, nebular emission lines, measure their wavelengths and estimate their fluxes. Results. A linelist of 1500 lines is presented for the maximum and minimum states of combined Weigelt blobs B and D. The spectra are dominated by emission lines from the iron-group elements, but include lines from lighter elements. They include parity permitted and forbidden lines. A number of lines are fluorescent lines pumped by H Ly alpha. Other lines show anomalous excitation.

The large area KX quasar catalogue - I. Analysis of the photometric redshift selection and the complete quasar catalogue

NASA Astrophysics Data System (ADS)

Maddox, Natasha; Hewett, Paul C.; Péroux, Céline; Nestor, Daniel B.; Wisotzki, Lutz

2012-08-01

The results of a large area, ˜600 deg2, K-band flux-limited spectroscopic survey for luminous quasars are presented. The survey utilizes the UKIRT Infrared Deep Sky Survey (UKIDSS) Large Area Survey (LAS) in regions of sky within the Sloan Digital Sky Survey (SDSS) footprint. The K-band excess (KX) of all quasars with respect to Galactic stars is exploited in combination with a photometric redshift/classification scheme to identify quasar candidates for spectroscopic follow-up observations. The data contained within this investigation will be able to provide new constraints on the fraction of luminous quasars reddened by dust with E(B - V) ≤ 0.5 mag. The spectroscopic sample is defined using the K-band, 14.0 ≤ K ≤ 16.6, and SDSS i-band limits of i = 19.5, 19.7 and 22.0 over sky areas of 287, 150 and 196 deg2, respectively. The survey includes >3200 known quasars from the SDSS and more than 250 additional confirmed quasars from the KX selection. A well-defined subsample of quasars in the redshift interval 1.0 ≤ z ≤ 3.5 includes 1152 objects from the SDSS and 172 additional KX-selected quasars. The quasar selection is >95 per cent complete with respect to known SDSS quasars and >95 per cent efficient, largely independent of redshift and i-band magnitude. The properties of the new KX-selected quasars confirm the known redshift-dependent effectiveness of the SDSS quasar selection and provide a sample of luminous quasars experiencing intermediate levels of extinction by dust. The catalogue represents an important step towards the assembly of a well-defined sample of luminous quasars that may be used to investigate the properties of quasars experiencing intermediate levels of dust extinction within their host galaxies or due intervening absorption line systems. †Based on observations made with ESO telescopes at the La Silla Paranal Observatory under programme IDs 083.A0360 and 085.A0359.‡Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC).

Collagen analysis by second-harmonic generation microscopy predicts outcome of luminal breast cancer.

PubMed

Natal, Rodrigo A; Vassallo, José; Paiva, Geisilene R; Pelegati, Vitor B; Barbosa, Guilherme O; Mendonça, Guilherme R; Bondarik, Caroline; Derchain, Sophie F; Carvalho, Hernandes F; Lima, Carmen S; Cesar, Carlos L; Sarian, Luís Otávio

2018-04-01

Second-harmonic generation microscopy represents an important tool to evaluate extracellular matrix collagen structure, which undergoes changes during cancer progression. Thus, it is potentially relevant to assess breast cancer development. We propose the use of second-harmonic generation images of tumor stroma selected on hematoxylin and eosin-stained slides to evaluate the prognostic value of collagen fibers analyses in peri and intratumoral areas in patients diagnosed with invasive ductal breast carcinoma. Quantitative analyses of collagen parameters were performed using ImageJ software. These parameters presented significantly higher values in peri than in intratumoral areas. Higher intratumoral collagen uniformity was associated with high pathological stages and with the presence of axillary lymph node metastasis. In patients with immunohistochemistry-based luminal subtype, higher intratumoral collagen uniformity and quantity were independently associated with poorer relapse-free and overall survival, respectively. A multivariate response recursive partitioning model determined 12.857 and 11.894 as the best cut-offs for intratumoral collagen quantity and uniformity, respectively. These values have shown high sensitivity and specificity to differentiate distinct outcomes. Values of intratumoral collagen quantity and uniformity exceeding the cut-offs were strongly associated with poorer relapse-free and overall survival. Our findings support a promising prognostic value of quantitative evaluation of intratumoral collagen by second-harmonic generation imaging mainly in the luminal subtype breast cancer.

The VIMOS Ultra Deep Survey. Luminosity and stellar mass dependence of galaxy clustering at z 3

NASA Astrophysics Data System (ADS)

Durkalec, A.; Le Fèvre, O.; Pollo, A.; Zamorani, G.; Lemaux, B. C.; Garilli, B.; Bardelli, S.; Hathi, N.; Koekemoer, A.; Pforr, J.; Zucca, E.

2018-04-01

We present a study of the dependence of galaxy clustering on luminosity and stellar mass in the redshift range 2 < z < 3.5 using 3236 galaxies with robust spectroscopic redshifts from the VIMOS Ultra Deep Survey (VUDS), covering a total area of 0.92 deg2. We measured the two-point real-space correlation function wp(rp) for four volume-limited subsamples selected by stellar mass and four volume-limited subsamples selected by MUV absolute magnitude. We find that the scale-dependent clustering amplitude r0 significantly increases with increasing luminosity and stellar mass. For the least luminous galaxies (MUV < -19.0), we measured a correlation length r0 = 2.87 ± 0.22 h-1 Mpc and slope γ = 1.59 ± 0.07, while for the most luminous (MUV < -20.2) r0 = 5.35 ± 0.50 h-1 Mpc and γ = 1.92 ± 0.25. These measurements correspond to a strong relative bias between these two subsamples of Δb/b* = 0.43. Fitting a five-parameter halo occupation distribution (HOD) model, we find that the most luminous (MUV < -20.2) and massive (M⋆ > 1010 h-1 M⊙) galaxies occupy the most massive dark matter haloes with ⟨Mh⟩ = 1012.30 h-1 M⊙. Similar to the trends observed at lower redshift, the minimum halo mass Mmin depends on the luminosity and stellar mass of galaxies and grows from Mmin = 109.73 h-1 M⊙ to Mmin = 1011.58 h-1 M⊙ from the faintest to the brightest among our galaxy sample, respectively. We find the difference between these halo masses to be much more pronounced than is observed for local galaxies of similar properties. Moreover, at z 3, we observe that the masses at which a halo hosts, on average, one satellite and one central galaxy is M1 ≈ 4Mmin over all luminosity ranges, which is significantly lower than observed at z 0; this indicates that the halo satellite occupation increases with redshift. The luminosity and stellar mass dependence is also reflected in the measurements of the large-scale galaxy bias, which we model as bg,HOD (>L) = 1.92 + 25.36(L/L*)7.01. We conclude our study with measurements of the stellar-to-halo mass ratio (SHMR). We observe a significant model-observation discrepancy for low-mass galaxies, suggesting a higher than expected star formation efficiency of these galaxies. Based on data obtained with the European Southern Observatory Very Large Telescope, Paranal, Chile, under Large Programme 185.A-0791.

Clinical evaluation of a medical high dynamic range display

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marchessoux, Cedric, E-mail: cedric.marchessoux@ba

Purpose: Recent new medical displays do have higher contrast and higher luminance but do not have a High Dynamic Range (HDR). HDR implies a minimum luminance value close to zero. A medical HDR display prototype based on two Liquid Crystal layers has been developed. The goal of this study is to evaluate the potential clinical benefit of such display in comparison with a low dynamic range (LDR) display. Methods: The study evaluated the clinical performance of the displays in a search and detection task. Eight radiologists read chest x-ray images some of which contained simulated lung nodules. The study usedmore » a JAFROC (Jacknife Free Receiver Operating Characteristic) approach for analyzing FROC data. The calculated figure of merit (FoM) is the probability that a lesion is rated higher than all rated nonlesions on all images. Time per case and accuracy for locating the center of the nodules were also compared. The nodules were simulated using Samei’s model. 214 CR and DR images [half were “healthy images” (chest nodule-free) and half “diseased images”] were used resulting in a total number of nodules equal to 199 with 25 images with 1 nodule, 51 images with 2 nodules, and 24 images with 3 nodules. A dedicated software interface was designed for visualizing the images for each session. For the JAFROC1 statistical analysis, the study is done per nodule category: all nodules, difficult nodules, and very difficult nodules. Results: For all nodules, the averaged FoM{sub HDR} is slightly higher than FoM{sub LDR} with 0.09% of difference. For the difficult nodules, the averaged FoM{sub HDR} is slightly higher than FoM{sub LDR} with 1.38% of difference. The averaged FoM{sub HDR} is slightly higher than FoM{sub LDR} with 0.71% of difference. For the true positive fraction (TPF), both displays (the HDR and the LDR ones) have similar TPF for all nodules, but looking at difficult and very difficult nodules, there are more TP for the HDR display. The true positive fraction has been also computed in function of the local average luminance around the nodules. For the lowest luminance range, there is more than 30% in favor of the HDR display. For the highest luminance range, there is less than 6% in favor of the LDR display. Conclusions: This study shows the potential benefit of using a HDR display in radiology.« less

The Physical Study of Atmospheric Luminous Anomalies and the SETV Hypothesis

NASA Astrophysics Data System (ADS)

Teodorani, M.

2002-04-01

On the basis of statistical calculations on galactic migration which bring the necessity of insertion of a new parameter inside the Drake formula, the work-hypothesis named SETV predicts that exogenous vehicles and/or probes may have reached the Solar System too, including Earth. The technology which is now available is able to allow sensing operations both in the extreme borders of the solar system and on our own planet. The possible presence of probes of possible extraterrestrial origin on our planet may be ascertained by using a network of sensing stations which are placed in critical areas. One of them is the norwegian area of Hessdalen, where the two scientific explorative missions of `Project EMBLA' have carried out measurements which demonstrate the existence of all the anomalies of the luminous phenomenon which is present there. At present nothing proves scientifically that our planet is being visited by alien intelligences, nevertheless the remarkable peculiarity which was learnt in some areas of recurrence demonstrate that the verified phenomenology, of extreme importance for fundamental physics, presents characteristics which deserve a further investigation with highly sophisticated instrumentation.

Visual feature-tolerance in the reading network.

PubMed

Rauschecker, Andreas M; Bowen, Reno F; Perry, Lee M; Kevan, Alison M; Dougherty, Robert F; Wandell, Brian A

2011-09-08

A century of neurology and neuroscience shows that seeing words depends on ventral occipital-temporal (VOT) circuitry. Typically, reading is learned using high-contrast line-contour words. We explored whether a specific VOT region, the visual word form area (VWFA), learns to see only these words or recognizes words independent of the specific shape-defining visual features. Word forms were created using atypical features (motion-dots, luminance-dots) whose statistical properties control word-visibility. We measured fMRI responses as word form visibility varied, and we used TMS to interfere with neural processing in specific cortical circuits, while subjects performed a lexical decision task. For all features, VWFA responses increased with word-visibility and correlated with performance. TMS applied to motion-specialized area hMT+ disrupted reading performance for motion-dots, but not line-contours or luminance-dots. A quantitative model describes feature-convergence in the VWFA and relates VWFA responses to behavioral performance. These findings suggest how visual feature-tolerance in the reading network arises through signal convergence from feature-specialized cortical areas. Copyright © 2011 Elsevier Inc. All rights reserved.

76 FR 76625 - Association of State and Territorial Solid Waste Management Officials; Denial of Petition for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-08

... luminous exit signs do not require electricity or batteries, and are commonly installed in areas where... tritium exit signs are returned to the manufacturer for recycling or disposed of as low-level radioactive...

Two-flash thresholds as a function of flash luminance and area.

DOT National Transportation Integrated Search

1968-09-01

The recent use of strobe lights in aviation suggests the possibility of using temporal patterns of short duration flashes as information-carrying signals. Under night flight conditions, two-flash thresholds were obtained using a two-interval, tempora...

Gravitational Lensing in Astronomy

NASA Astrophysics Data System (ADS)

Wambsganss, Joachim

1998-11-01

In addition to multiply-imaged quasars, a number of other aspects of lensing have been discovered: For example, giant luminous arcs, quasar microlensing, Einstein rings, galactic microlensing events, arclets, and weak gravitational lensing. At present, literally hundreds of individual gravitational lens phenomena are known. Although still in its childhood, lensing has established itself as a very useful astrophysical tool with some remarkable successes. It has contributed significant new results in areas as different as the cosmological distance scale, the large scale matter distribution in the universe, mass and mass distribution of galaxy clusters, the physics of quasars, dark matter in galaxy halos, and galaxy structure. Looking at these successes in the recent past we predict an even more luminous future for gravitational lensing.

Assimilative and non-assimilative color spreading in the watercolor configuration.

PubMed

Kimura, Eiji; Kuroki, Mikako

2014-01-01

A colored line flanking a darker contour will appear to spread its color onto an area enclosed by the line (watercolor effect). The watercolor effect has been characterized as an assimilative effect, but non-assimilative color spreading has also been demonstrated in the same spatial configuration; e.g., when a black inner contour (IC) is paired with a blue outer contour (OC), yellow color spreading can be observed. To elucidate visual mechanisms underlying these different color spreading effects, this study investigated the effects of luminance ratio between the double contours on the induced color by systematically manipulating the IC and the OC luminance (Experiment 1) as well as the background luminance (Experiment 2). The results showed that the luminance conditions suitable for assimilative and non-assimilative color spreading were nearly opposite. When the Weber contrast of the IC to the background luminance (IC contrast) was smaller in size than that of the OC (OC contrast), the induced color became similar to the IC color (assimilative spreading). In contrast, when the OC contrast was smaller than or equal to the IC contrast, the induced color became yellow (non-assimilative spreading). Extending these findings, Experiment 3 showed that bilateral color spreading, i.e., assimilative spreading on one side and non-assimilative spreading on the other side, can also be observed in the watercolor configuration. These results suggest that the assimilative and the non-assimilative spreading were mediated by different visual mechanisms. The properties of the assimilative spreading are consistent with the model proposed to account for neon color spreading (Grossberg and Mingolla, 1985) and extended for the watercolor effect (Pinna and Grossberg, 2005). However, the present results suggest that additional mechanisms are needed to account for the non-assimilative color spreading.

A dark energy camera search for missing supergiants in the LMC after the advanced LIGO gravitational-wave event GW150914

DOE PAGES

Annis, J.

2016-05-27

The collapse of a stellar core is expected to produce gravitational waves (GWs), neutrinos, and in most cases a luminous supernova. Sometimes, however, the optical event could be significantly less luminous than a supernova and a direct collapse to a black hole, where the star just disappears, is possible. The GW event GW150914 was detected by the LIGO Virgo Collaboration via a burst analysis that gave localization contours enclosing the Large Magellanic Cloud (LMC). Shortly thereafter, we used DECam to observe 102 deg 2 of the localization area, including 38 deg 2 on the LMC for a missing supergiant search.more » We construct a complete catalog of LMC luminous red supergiants, the best candidates to undergo invisible core collapse, and collected catalogs of other candidates: less luminous red supergiants, yellow supergiants, blue supergiants, luminous blue variable stars, and Wolf–Rayet stars. Of the objects in the imaging region, all are recovered in the images. The timescale for stellar disappearance is set by the free-fall time, which is a function of the stellar radius. Our observations at 4 and 13 days after the event result in a search sensitive to objects of up to about 200 solar radii. We conclude that it is unlikely that GW150914 was caused by the core collapse of a relatively compact supergiant in the LMC, consistent with the LIGO Collaboration analyses of the gravitational waveform as best interpreted as a high mass binary black hole merger. Lastly, we discuss how to generalize this search for future very nearby core-collapse candidates.« less

Coronaridine congeners inhibit human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites.

PubMed

Arias, Hugo R; Targowska-Duda, Katarzyna M; Feuerbach, Dominik; Jozwiak, Krzysztof

2015-08-01

To characterize the interaction of coronaridine congeners with human (h) α3β4 nicotinic acetylcholine receptors (AChRs), structural and functional approaches were used. The Ca(2+) influx results established that coronaridine congeners noncompetitively inhibit hα3β4 AChRs with the following potency (IC50's in μM) sequence: (-)-ibogamine (0.62±0.23)∼(+)-catharanthine (0.68±0.10)>(-)-ibogaine (0.95±0.10)>(±)-18-methoxycoronaridine [(±)-18-MC] (1.47±0.21)>(-)-voacangine (2.28±0.33)>(±)-18-methylaminocoronaridine (2.62±0.57 μM)∼(±)-18-hydroxycoronaridine (2.81±0.54)>(-)-noribogaine (6.82±0.78). A good linear correlation (r(2)=0.771) between the calculated IC50 values and their polar surface area was found, suggesting that this is an important structural feature for its activity. The radioligand competition results indicate that (±)-18-MC and (-)-ibogaine partially inhibit [(3)H]imipramine binding by an allosteric mechanism. Molecular docking, molecular dynamics, and in silico mutation results suggest that protonated (-)-18-MC binds to luminal [i.e., β4-Phe255 (phenylalanine/valine ring; position 13'), and α3-Leu250 and β4-Leu251 (leucine ring; position 9')], non-luminal, and intersubunit sites. The pharmacophore model suggests that nitrogens from the ibogamine core as well as methylamino, hydroxyl, and methoxyl moieties at position 18 form hydrogen bonds. Collectively our data indicate that coronaridine congeners inhibit hα3β4 AChRs by blocking the ion channel's lumen and probably by additional negative allosteric mechanisms by interacting with a series of non-luminal sites. Copyright © 2015 Elsevier Ltd. All rights reserved.

An evaluation of organic light emitting diode monitors for medical applications: Great timing, but luminance artifacts

PubMed Central

Elze, Tobias; Taylor, Christopher; Bex, Peter J.

2013-01-01

Purpose: In contrast to the dominant medical liquid crystal display (LCD) technology, organic light-emitting diode (OLED) monitors control the display luminance via separate light-emitting diodes for each pixel and are therefore supposed to overcome many previously documented temporal artifacts of medical LCDs. We assessed the temporal and luminance characteristics of the only currently available OLED monitor designed for use in the medical treatment field (SONY PVM2551MD) and checked the authors’ main findings with another SONY OLED device (PVM2541). Methods: Temporal properties of the photometric output were measured with an optical transient recorder. Luminances of the three color primaries and white for all 256 digital driving levels (DDLs) were measured with a spectroradiometer. Between the luminances of neighboring DDLs, just noticeable differences were calculated according to a perceptual model developed for medical displays. Luminances of full screen (FS) stimuli were compared to luminances of smaller stimuli with identical DDLs. Results: All measured luminance transition times were below 300 μs. Luminances were independent of the luminance in the preceding frame. However, for the single color primaries, up to 50.5% of the luminances of neighboring DDLs were not perceptually distinguishable. If two color primaries were active simultaneously, between 36.7% and 55.1% of neighboring luminances for increasing DDLs of the third primary were even decreasing. Moreover, luminance saturation effects were observed when too many pixels were active simultaneously. This effect was strongest for white; a small white patch was close to 400 cd/m2, but in FS the luminance of white saturated at 162 cd/m2. Due to different saturation levels, the luminance of FS green and FS yellow could exceed the luminance of FS white for identical DDLs. Conclusions: The OLED temporal characteristics are excellent and superior to those of LCDs. However, the OLEDs revealed severe perceptually relevant artifacts with implications for applicability to medical imaging. PMID:24007183

An evaluation of organic light emitting diode monitors for medical applications: great timing, but luminance artifacts.

PubMed

Elze, Tobias; Taylor, Christopher; Bex, Peter J

2013-09-01

In contrast to the dominant medical liquid crystal display (LCD) technology, organic light-emitting diode (OLED) monitors control the display luminance via separate light-emitting diodes for each pixel and are therefore supposed to overcome many previously documented temporal artifacts of medical LCDs. We assessed the temporal and luminance characteristics of the only currently available OLED monitor designed for use in the medical treatment field (SONY PVM2551MD) and checked the authors' main findings with another SONY OLED device (PVM2541). Temporal properties of the photometric output were measured with an optical transient recorder. Luminances of the three color primaries and white for all 256 digital driving levels (DDLs) were measured with a spectroradiometer. Between the luminances of neighboring DDLs, just noticeable differences were calculated according to a perceptual model developed for medical displays. Luminances of full screen (FS) stimuli were compared to luminances of smaller stimuli with identical DDLs. All measured luminance transition times were below 300 μs. Luminances were independent of the luminance in the preceding frame. However, for the single color primaries, up to 50.5% of the luminances of neighboring DDLs were not perceptually distinguishable. If two color primaries were active simultaneously, between 36.7% and 55.1% of neighboring luminances for increasing DDLs of the third primary were even decreasing. Moreover, luminance saturation effects were observed when too many pixels were active simultaneously. This effect was strongest for white; a small white patch was close to 400 cd/m(2), but in FS the luminance of white saturated at 162 cd/m(2). Due to different saturation levels, the luminance of FS green and FS yellow could exceed the luminance of FS white for identical DDLs. The OLED temporal characteristics are excellent and superior to those of LCDs. However, the OLEDs revealed severe perceptually relevant artifacts with implications for applicability to medical imaging.

High-performance large-area AMLCD avionic display module

NASA Astrophysics Data System (ADS)

Syroid, Daniel D.; Hansen, Glenn A.

1995-06-01

There is a need for a reliable source of high performance large area sunlight readable active matrix liquid crystal displays (AMLCDs) for avionic and military land vehicle applications. Image Quest has developed an avionic display module (ADM) to demonstrate the capability to produce high performance avionic displays to satisfy this need. The ADM is a large area (6.24 X 8.32 inch) display with VGA compatible interface, 640 X 480 color pixels and 64 gray shades per primary color. The display features excellent color discrimination in full sunlight due to a saturated color gamut, very low specular reflectance (< 1%) and high output white luminance (200 fL). The ADM is designed from the glass up to fully meet the avionic and military application and environment. Control over all the display performance parameters including contrast, transmission, chroma, resolution, active size and packaging configuration is ensured because Image Quest produces all of the critical elements of the display. These elements include the a-Si TFT AMLCD glass, RGB color filter matrix, bonding of folded back driver TABs, anti-reflective cover glass, LC heater and integration of high luminance hot cathode backlight with thermal controls. The display features rugged compact packaging, 2000:1 luminance dimming range and wide operating temperature range (-40 to +71 $DRGC). In the immediate future Image Quest plans to expand the development efforts to other similar custom high resolution and high performance avionic display module configurations including 4 X 4 inch delta triad, 6.7 X 6.7 inch delta triad and 16.5 inch diagonal with 1280 X 1024 pixels. Image Quest can deliver up to 10,000 displays per year on a timely basis at a reasonable cost.

Luminous Phenomena - A Scientific Investigation of Anomalous Luminous Atmospheric Phenomena

NASA Astrophysics Data System (ADS)

Teodorani, M.

2003-12-01

Anomalous atmospheric luminous phenomena reoccur in several locations of Earth, in the form of multi-color light balls characterized by large dimensions, erratic motion, long duration and a correlated electromagnetic field. The author (an astrophysicist) of this book, which is organized as a selection of some of his technical and popularizing papers and seminars, describes and discusses all the efforts that have been done in 10 years, through several missions and a massive data analysis, in order to obtain some scientific explanation of this kind of anomalies, in particular the Hessdalen anomaly in Norway. The following topics are treated in the book: a) geographic archive of the areas of Earth where such phenomena are known to reoccur most often; b) observational techniques of astrophysical kind that have been used to acquire the data; c) main scientific results obtained so far; d) physical interpretation and natural hypothesis vs. ETV hypothesis; e) historical and chronological issues; f) the importance to brindle new energy sources; g) the importance to keep distance from any kind of "ufology". An unpublished chapter is entirely devoted to a detailed scientific investigation project of light phenomena reoccurring on the Ontario lake; the chosen new-generation multi-wavelength sensing instrumentation that is planned to be used in future missions in that specific area, is described together with scientific rationale and planned procedures. The main results, which were obtained in other areas of the world, such as the Arizona desert, USA and the Sibillini Mountains, Italy, are also briefly mentioned. One chapter is entirely dedicated to the presentation of extensive abstracts of technical papers by the author concerning this specific subject. The book is accompanied with a rich source of bibliographic references.

Wavefront coherence area for predicting visual acuity of post-PRK and post-PARK refractive surgery patients

NASA Astrophysics Data System (ADS)

Garcia, Daniel D.; van de Pol, Corina; Barsky, Brian A.; Klein, Stanley A.

1999-06-01

Many current corneal topography instruments (called videokeratographs) provide an `acuity index' based on corneal smoothness to analyze expected visual acuity. However, post-refractive surgery patients often exhibit better acuity than is predicted by such indices. One reason for this is that visual acuity may not necessarily be determined by overall corneal smoothness but rather by having some part of the cornea able to focus light coherently onto the fovea. We present a new method of representing visual acuity by measuring the wavefront aberration, using principles from both ray and wave optics. For each point P on the cornea, we measure the size of the associated coherence area whose optical path length (OPL), from a reference plane to P's focus, is within a certain tolerance of the OPL for P. We measured the topographies and vision of 62 eyes of patients who had undergone the corneal refractive surgery procedures of photorefractive keratectomy (PRK) and photorefractive astigmatic keratectomy (PARK). In addition to high contrast visual acuity, our vision tests included low contrast and low luminance to test the contribution of the PRK transition zone. We found our metric for visual acuity to be better than all other metrics at predicting the acuity of low contrast and low luminance. However, high contrast visual acuity was poorly predicted by all of the indices we studied, including our own. The indices provided by current videokeratographs sometimes fail for corneas whose shape differs from simple ellipsoidal models. This is the case with post-PRK and post-PARK refractive surgery patients. Our alternative representation that displays the coherence area of the wavefront has considerable advantages, and promises to be a better predictor of low contrast and low luminance visual acuity than current shape measures.

Binocular combination of luminance profiles

PubMed Central

Ding, Jian; Levi, Dennis M.

2017-01-01

We develop and test a new two-dimensional model for binocular combination of the two eyes' luminance profiles. For first-order stimuli, the model assumes that one eye's luminance profile first goes through a luminance compressor, receives gain-control and gain-enhancement from the other eye, and then linearly combines the other eye's output profile. For second-order stimuli, rectification is added in the signal path of the model before the binocular combination site. Both the total contrast and luminance energies, weighted sums over both the space and spatial-frequency domains, were used in the interocular gain-control, while only the total contrast energy was used in the interocular gain-enhancement. To challenge the model, we performed a binocular brightness matching experiment over a large range of background and target luminances. The target stimulus was a dichoptic disc with a sharp edge that has an increment or decrement luminance from its background. The disk's interocular luminance ratio varied from trial to trial. To refine the model we tested three luminance compressors, five nested binocular combination models (including the Ding–Sperling and the DSKL models), and examined the presence or absence of total luminance energy in the model. We found that (1) installing a luminance compressor, either a logarithmic luminance function or luminance gain-control, (2) including both contrast and luminance energies, and (3) adding interocular gain-enhancement (the DSKL model) to a combined model significantly improved its performance. The combined model provides a systematic account of binocular luminance summation over a large range of luminance input levels. It gives a unified explanation of Fechner's paradox observed on a dark background, and a winner-take-all phenomenon observed on a light background. To further test the model, we conducted two additional experiments: luminance summation of discs with asymmetric contour information (Experiment 2), similar to Levelt (1965) and binocular combination of second-order contrast-modulated gratings (Experiment 3). We used the model obtained in Experiment 1 to predict the results of Experiments 2 and 3 and the results of our previous studies. Model simulations further refined the contrast space weight and contrast sensitivity functions that are installed in the model, and provide a reasonable account for rebalancing of imbalanced binocular vision by reducing the mean luminance in the dominant eye. PMID:29098293

A comparison of Ki-67 counting methods in luminal Breast Cancer: The Average Method vs. the Hot Spot Method

PubMed Central

Jang, Min Hye; Kim, Hyun Jung; Chung, Yul Ri; Lee, Yangkyu

2017-01-01

In spite of the usefulness of the Ki-67 labeling index (LI) as a prognostic and predictive marker in breast cancer, its clinical application remains limited due to variability in its measurement and the absence of a standard method of interpretation. This study was designed to compare the two methods of assessing Ki-67 LI: the average method vs. the hot spot method and thus to determine which method is more appropriate in predicting prognosis of luminal/HER2-negative breast cancers. Ki-67 LIs were calculated by direct counting of three representative areas of 493 luminal/HER2-negative breast cancers using the two methods. We calculated the differences in the Ki-67 LIs (ΔKi-67) between the two methods and the ratio of the Ki-67 LIs (H/A ratio) of the two methods. In addition, we compared the performance of the Ki-67 LIs obtained by the two methods as prognostic markers. ΔKi-67 ranged from 0.01% to 33.3% and the H/A ratio ranged from 1.0 to 2.6. Based on the receiver operating characteristic curve method, the predictive powers of the KI-67 LI measured by the two methods were similar (Area under curve: hot spot method, 0.711; average method, 0.700). In multivariate analysis, high Ki-67 LI based on either method was an independent poor prognostic factor, along with high T stage and node metastasis. However, in repeated counts, the hot spot method did not consistently classify tumors into high vs. low Ki-67 LI groups. In conclusion, both the average and hot spot method of evaluating Ki-67 LI have good predictive performances for tumor recurrence in luminal/HER2-negative breast cancers. However, we recommend using the average method for the present because of its greater reproducibility. PMID:28187177

A comparison of Ki-67 counting methods in luminal Breast Cancer: The Average Method vs. the Hot Spot Method.

PubMed

Jang, Min Hye; Kim, Hyun Jung; Chung, Yul Ri; Lee, Yangkyu; Park, So Yeon

2017-01-01

In spite of the usefulness of the Ki-67 labeling index (LI) as a prognostic and predictive marker in breast cancer, its clinical application remains limited due to variability in its measurement and the absence of a standard method of interpretation. This study was designed to compare the two methods of assessing Ki-67 LI: the average method vs. the hot spot method and thus to determine which method is more appropriate in predicting prognosis of luminal/HER2-negative breast cancers. Ki-67 LIs were calculated by direct counting of three representative areas of 493 luminal/HER2-negative breast cancers using the two methods. We calculated the differences in the Ki-67 LIs (ΔKi-67) between the two methods and the ratio of the Ki-67 LIs (H/A ratio) of the two methods. In addition, we compared the performance of the Ki-67 LIs obtained by the two methods as prognostic markers. ΔKi-67 ranged from 0.01% to 33.3% and the H/A ratio ranged from 1.0 to 2.6. Based on the receiver operating characteristic curve method, the predictive powers of the KI-67 LI measured by the two methods were similar (Area under curve: hot spot method, 0.711; average method, 0.700). In multivariate analysis, high Ki-67 LI based on either method was an independent poor prognostic factor, along with high T stage and node metastasis. However, in repeated counts, the hot spot method did not consistently classify tumors into high vs. low Ki-67 LI groups. In conclusion, both the average and hot spot method of evaluating Ki-67 LI have good predictive performances for tumor recurrence in luminal/HER2-negative breast cancers. However, we recommend using the average method for the present because of its greater reproducibility.

Genome-wide Search of Oncogenic Pathways Cooperating with ETS Fusions in Prostate Cancer

DTIC Science & Technology

2013-07-01

luminal cells cannot engraft well in this assay), and although both luminal and basal cells could serve as cells of origin of prostate cancer, luminal ...was the need for them to differentiate into luminal cells first [27]. Thus, it appears that prostate luminal cells may serve as the major cellular...origin for prostate cancer. We therefore more favor a strategy to search for ETS-cooperating mutations in prostate luminal cells. Furthermore

[The project and simulation of a compositive miniature spectrum instrument based on the array of Fabry-Perot cavity].

PubMed

Wen, Zhi-yu; Chen, Gang; Wang, Jian-guo

2006-10-01

This paper advances a kind of micro-spectrometer based on Fabry-Perot cavity's character of filtering the waves. The basic structure of the micro-spectrometer is the array of Fabry-Perot cavity which contains many different lengths of cavity on the substrate of silicon, consequently the authors can achieve the detection at several wavelengths simultaneously. The unit of probing is a Fabry-Perot cavity made up of the substrate of silicon-metal film-silicon dioxide layer-metal film. The authors carried out the corresponding simulation. In the basic structure of aluminum film(14 nm)-silicon dioxide layer-silver film(39 nm), the resolution can reach 15 nm. When the area of a unit of probing is 0.14 mm x 0.14 mm only, it can reach the luminous flux of miniature grating spectrum instrument (the minimum volume in the order of cm), but the volume of the part of spectrum detection is only of the order of mm. The design size of the micro-spectrometer is a few millimeters. Furthermore it has no movable parts and could detect several wavelengths at the same time. It is possible to fabricate such micro-spectrometer through existing processing methods of IC technology.

Threshold setting by the surround of cat retinal ganglion cells.

PubMed

Barlow, H B; Levick, W R

1976-08-01

1. The slope of curves relating the log increment threshold to log background luminance in cat retinal ganglion cells is affected by the area and duration of the test stimulus, as it is in human pyschophysical experiments. 2. Using large area, long duration stimuli the slopes average 0-82 and approach close to 1 (Weber's Law) in the steepest cases. Small stimuli gave an average of 0-53 for on-centre units using brief stimuli, and 0-56 for off-centre units, using long stimuli. Slopes under 0-5 (square root law) were not found over an extended range of luminances. 3. On individual units the slope was generally greater for larger and longer test stimulus, but no unit showed the full extent of change from slope of 0-5 to slope of 1. 4. The above differences hold for objective measures of quantum/spike ratio, as well as for thresholds either judged by ear or assessed by calculation. 5. The steeper slope of the curves for large area, long duration test stimuli compared with small, long duration stimuli, is associated with the increased effectiveness of antagonism from the surround at high backgrounds. This change may be less pronounced in off-centre units, one of which (probably transient Y-type) showed no difference of slope, and gave parallel area-threshold curves at widely separated background luminances, confirming the importance of differential surround effectiveness in changing the slope of the curves. 6. In on-centre units, the increased relative effectiveness of the surround is associated with the part of the raised background light that falls on the receptive field centre. 7. It is suggested that the variable surround functions as a zero-offset control that sets the threshold excitation required for generating impulses, and that this is separate from gain-setting adaptive mechanisms. This may be how ganglion cells maintain high incremental sensitivity in spite of a strong maintained excitatory drive that would otherwise cause compressive response non-linearities.

Minimum area thresholds for rattlesnakes and colubrid snakes on islands in the Gulf of California, Mexico.

PubMed

Meik, Jesse M; Makowsky, Robert

2018-01-01

We expand a framework for estimating minimum area thresholds to elaborate biogeographic patterns between two groups of snakes (rattlesnakes and colubrid snakes) on islands in the western Gulf of California, Mexico. The minimum area thresholds for supporting single species versus coexistence of two or more species relate to hypotheses of the relative importance of energetic efficiency and competitive interactions within groups, respectively. We used ordinal logistic regression probability functions to estimate minimum area thresholds after evaluating the influence of island area, isolation, and age on rattlesnake and colubrid occupancy patterns across 83 islands. Minimum area thresholds for islands supporting one species were nearly identical for rattlesnakes and colubrids (~1.7 km 2 ), suggesting that selective tradeoffs for distinctive life history traits between rattlesnakes and colubrids did not result in any clear advantage of one life history strategy over the other on islands. However, the minimum area threshold for supporting two or more species of rattlesnakes (37.1 km 2 ) was over five times greater than it was for supporting two or more species of colubrids (6.7 km 2 ). The great differences between rattlesnakes and colubrids in minimum area required to support more than one species imply that for islands in the Gulf of California relative extinction risks are higher for coexistence of multiple species of rattlesnakes and that competition within and between species of rattlesnakes is likely much more intense than it is within and between species of colubrids.

Influence of Spatial and Chromatic Noise on Luminance Discrimination.

PubMed

Miquilini, Leticia; Walker, Natalie A; Odigie, Erika A; Guimarães, Diego Leite; Salomão, Railson Cruz; Lacerda, Eliza Maria Costa Brito; Cortes, Maria Izabel Tentes; de Lima Silveira, Luiz Carlos; Fitzgerald, Malinda E C; Ventura, Dora Fix; Souza, Givago Silva

2017-12-05

Pseudoisochromatic figures are designed to base discrimination of a chromatic target from a background solely on the chromatic differences. This is accomplished by the introduction of luminance and spatial noise thereby eliminating these two dimensions as cues. The inverse rationale could also be applied to luminance discrimination, if spatial and chromatic noise are used to mask those cues. In this current study estimate of luminance contrast thresholds were conducted using a novel stimulus, based on the use of chromatic and spatial noise to mask the use of these cues in a luminance discrimination task. This was accomplished by presenting stimuli composed of a mosaic of circles colored randomly. A Landolt-C target differed from the background only by the luminance. The luminance contrast thresholds were estimated for different chromatic noise saturation conditions and compared to luminance contrast thresholds estimated using the same target in a non-mosaic stimulus. Moreover, the influence of the chromatic content in the noise on the luminance contrast threshold was also investigated. Luminance contrast threshold was dependent on the chromaticity noise strength. It was 10-fold higher than thresholds estimated from non-mosaic stimulus, but they were independent of colour space location in which the noise was modulated. The present study introduces a new method to investigate luminance vision intended for both basic science and clinical applications.

Luminous bacteria cultured from fish guts in the Gulf of Oman.

PubMed

Makemson, J C; Hermosa, G V

1999-01-01

The incidence of culturable luminous bacteria in Omani market fish guts was correlated to habitat type amongst 109 species of fish. Isolated representative luminous bacteria were compared to known species using the Biolog system (95 traits/isolate) and cluster analysis, which showed that the main taxa present in fish guts were clades related to Vibrio harveyi and Photobacterium species with sporadic incidence of P. phosphoreum. The luminous isolates from gut of the slip-mouth (barred pony fish), Leiognathus fasciatus, were mainly a type related to Photobacterium but phenotypically different from known species. These luminous gut bacteria were identical with the bacteria in the light organ, indicating that the light organ supplies a significant quantity of luminous bacteria to the gut. In many of the fish that lack light organs, luminous bacteria were also the dominant bacterial type in the gut, while in some others luminous bacteria were encountered sporadically and at low densities, reflecting the incidence of culturable luminous bacteria in seawater. Pelagic fish contained the highest incidence of culturable luminous bacteria and reef-associated fish the lowest. No correlation was found between the incidence of culturable luminous bacteria and the degree to which fish produce a melanin-covered gut. Copyright 1999 John Wiley & Sons, Ltd.

Determinants and Normal Values of Ascending Aortic Diameter by Age, Gender and Race/Ethnicity in the Multi-Ethnic Study of Atherosclerosis (MESA)

PubMed Central

Turkbey, Evrim B.; Jain, Aditya; Johnson, Craig; Redheuil, Alban; Arai, Andrew E.; Gomes, Antoinette S.; Carr, James; Hundley, W. Gregory; Teixido-Tura, Gisela; Eng, John; Lima, Joao A.C.; Bluemke, David A.

2013-01-01

PURPOSE To determine the normal size and wall thickness of the ascending thoracic aorta (AA) and its relationship with cardiovascular risk factors in a large population-based study. MATERIALS AND METHODS The mean AA luminal diameter was measured in 3573 Multi-Ethnic Study of Atherosclerosis (MESA) participants (age: 45–84 years), using gradient echo phase contrast cine MRI. Multiple linear regression models were used to evaluate the associations between risk factors and AA diameter. The median and upper normal limit (95th percentile) was defined in a “healthy” subgroup as well as AA wall thickness. RESULTS The upper limits of body surface area indexed AA luminal diameter for age categories of 45–54, 55–64, 65–74, and 75–84 years are 21, 22, 22, and 28 mm/m2 in women and 20, 21, 22, 23 mm/m2 in men, respectively. The mean AA wall thickness was 2.8 mm. Age, gender and body surface area were major determinants of AA luminal diameter (~+1 mm/10 years; ~+1.9 mm in men than women; ~+1 mm/ 0.23 m2; p<0.001). The AA diameter in hypertensive subjects was +0.9 mm larger than in normotensives (p<0.001). CONCLUSION AA diameter increases gradually with aging for both genders, among all race/ethnicities. Normal value of AA diameter is provided. PMID:23681649

Randomized Controlled Trial of Cholestyramine and Hydrotalcite to Eliminate Bile for Capsule Endoscopy

PubMed Central

Hong-Bin, Chen; Yue, Huang; Chun, Huang; Shu-Ping, Xiao; Yue, Zhang; Xiao-Lin, Li

2016-01-01

Background/Aims: Bile is the main cause of poor bowel preparation for capsule endoscopy (CE). We aimed to determine whether cholestyramine and hydrotalcite can eliminate bile in the bowel. Patients and Methods: Patients undergoing CE were randomized into two groups. Group A patients (n = 75) recieved 250 mL 20% mannitol and 1 L 0.9% saline orally at 20:00 hours on the day before and at 05:00 hours on the day of CE and 20 mL simethicone 30 min before CE. Group B patients (n = 73) were treated identically, except for taking oral cholestyramine and hydrotalcite, starting 3 days before CE. Greenish luminal contents were assessed by four tissue color bar segments using Color Area Statistics software. Bowel cleanliness was evaluated by visualized area percentage assessment of cleansing (AAC) score. Result: Bowel cleanliness (82.7% [62/75] vs 46.6% [34/73]; χ2 = 14.596, P = 0.000). and detected greenish luminal contents (20.0% [15/75] vs 8.2% [6/73]; χ2 = 4.217, P = 0.040) were significantly greater in Group A than in Group B. Greenish luminal contents in the two groups differed significantly in the captured small-bowel (t = −13.74, P = 0.000) segments and proximal small-bowel (t = −0.7365, P = 0.000) segments, but not for the distal small-bowel (t = −0.552, P = 0.581) segments. Conclusions: Cholestyramine and hydrotalcite were ineffective in eliminating bile and improving small-bowel preparation. PMID:26997218

Research on the calibration methods of the luminance parameter of radiation luminance meters

NASA Astrophysics Data System (ADS)

Cheng, Weihai; Huang, Biyong; Lin, Fangsheng; Li, Tiecheng; Yin, Dejin; Lai, Lei

2017-10-01

This paper introduces standard diffusion reflection white plate method and integrating sphere standard luminance source method to calibrate the luminance parameter. The paper compares the effects of calibration results by using these two methods through principle analysis and experimental verification. After using two methods to calibrate the same radiation luminance meter, the data obtained verifies the testing results of the two methods are both reliable. The results show that the display value using standard white plate method has fewer errors and better reproducibility. However, standard luminance source method is more convenient and suitable for on-site calibration. Moreover, standard luminance source method has wider range and can test the linear performance of the instruments.

Flux of Kilogram-Sized Meteoroids from Lunar Impact Monitoring

NASA Technical Reports Server (NTRS)

Suggs, Robert; Suggs, Ron; Cooke, William; McNamara, Heather; Diekmann, Anne; Moser, Danielle; Swift, Wesley

2008-01-01

Routine lunar impact monitoring has harvested over 110 impacts in 2 years of observations using 0.25, 0.36 and 0.5 m telescopes and low-light-level video cameras. The night side of the lunar surface provides a large collecting area for detecting these impacts and allows estimation of the flux of meteoroids down to a limiting luminous energy. In order to determine the limiting mass for these observations, models of the sporadic meteoroid environment were used to determine the velocity distribution and new measurements of luminous efficiency were made at the Ames Vertical Gun Range. The flux of meteoroids in this size range has implications for Near Earth Object populations as well as for estimating impact ejecta risk for future lunar missions.

Solar Minimum

NASA Astrophysics Data System (ADS)

Lopresto, James C.; Mathews, John; Manross, Kevin

1995-12-01

Calcium K plage, H alpha plage and sunspot area have been monitored daily on the INTERNET since November of 1992. The plage and sunspot area have been measured by image processing. The purpose of the project is to investigate the degree of correlation between plage area and solar irradiance. The plage variation shows the expected variation produced by solar rotation and the longer secular changes produced by the solar cycle. The H alpha and sunspot plage area reached a minimum in about late 1994 or early 1995. This is in agreement with the K2 spectral index obtained daily from Sacramento Peak Observatory. The Calcium K plage area minimum seems delayed with respect to the others mentioned above. The minimum of the K line plage area is projected to come within the last few months of 1995.

Interaction of aberrations, diffraction, and quantal fluctuations determine the impact of pupil size on visual quality.

PubMed

Xu, Renfeng; Wang, Huachun; Thibos, Larry N; Bradley, Arthur

2017-04-01

Our purpose is to develop a computational approach that jointly assesses the impact of stimulus luminance and pupil size on visual quality. We compared traditional optical measures of image quality and those that incorporate the impact of retinal illuminance dependent neural contrast sensitivity. Visually weighted image quality was calculated for a presbyopic model eye with representative levels of chromatic and monochromatic aberrations as pupil diameter was varied from 7 to 1 mm, stimulus luminance varied from 2000 to 0.1  cd/m², and defocus varied from 0 to -2 diopters. The model included the effects of quantal fluctuations on neural contrast sensitivity. We tested the model's predictions for five cycles per degree gratings by measuring contrast sensitivity at 5  cyc/deg. Unlike the traditional Strehl ratio and the visually weighted area under the modulation transfer function, the visual Strehl ratio derived from the optical transfer function was able to capture the combined impact of optics and quantal noise on visual quality. In a well-focused eye, provided retinal illuminance is held constant as pupil size varies, visual image quality scales approximately as the square root of illuminance because of quantum fluctuations, but optimum pupil size is essentially independent of retinal illuminance and quantum fluctuations. Conversely, when stimulus luminance is held constant (and therefore illuminance varies with pupil size), optimum pupil size increases as luminance decreases, thereby compensating partially for increased quantum fluctuations. However, in the presence of -1 and -2 diopters of defocus and at high photopic levels where Weber's law operates, optical aberrations and diffraction dominate image quality and pupil optimization. Similar behavior was observed in human observers viewing sinusoidal gratings. Optimum pupil size increases as stimulus luminance drops for the well-focused eye, and the benefits of small pupils for improving defocused image quality remain throughout the photopic and mesopic ranges. However, restricting pupils to <2  mm will cause significant reductions in the best focus vision at low photopic and mesopic luminances.

MRI of plaque characteristics and relationship with downstream perfusion and cerebral infarction in patients with symptomatic middle cerebral artery stenosis.

PubMed

Lu, Shan-Shan; Ge, Song; Su, Chun-Qiu; Xie, Jun; Mao, Jian; Shi, Hai-Bin; Hong, Xun-Ning

2017-10-30

Intracranial plaque characteristics are associated with stroke events. Differences in plaque features may explain the disconnect between stenosis severity and the presence of ischemic stroke. To investigate the relationship between plaque characteristics and downstream perfusion changes, and their contribution to the occurrence of cerebral infarction beyond luminal stenosis. Case control. Forty-six patients with symptomatic middle cerebral artery (MCA) stenosis (with acute cerebral infarction, n = 30; without acute cerebral infarction, n = 16). 3.0T with 3D turbo spin echo sequence (3D-SPACE). Luminal stenosis grade, plaque features including lesion T 2 and T 1 hyperintense components, plaque enhancement grade, and plaque distribution were assessed. Brain perfusion was evaluated on mean transient time maps based on the Alberta Stroke Program Early CT score (MTT-ASPECTS). Plaque features, grade of luminal stenosis, and MTT-ASPECTS were compared between two groups. The association between plaque features and MTT-ASPECTS were assessed using Spearman's correlation analysis. Multivariate logistic regression and receiver operating characteristic (ROC) curves were constructed to assess the effect of significant variables alone and their combination in determining the occurrence of cerebral infarction. Stronger enhanced plaques were associated with downstream lower MTT-ASPECTS (P = 0.010). Plaque enhancement grade (P = 0.039, odds ratio [OR] 5.9, 95% confidence interval [CI] 1.1-32) and MTT-ASPECTS (P = 0.003, OR 2.6, 95% CI 1.4-4.7) were associated with a recent cerebral infarction, whereas luminal stenosis grade was not (P = 0.128). The combination of MTT-ASPECTS and plaque enhancement grade provided incremental information beyond luminal stenosis grade alone. The area under the receiver operating characteristic curve (AUC) improved from 0.535 to 0.921 (P < 0.05). Strongly enhanced plaques are associated with a higher likelihood of downstream perfusion impairment. Plaque enhancement and perfusion evaluation may play a complementary role to luminal stenosis in determining the occurrence of acute cerebral infarction. 4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017. © 2017 International Society for Magnetic Resonance in Medicine.

Extensive Transcriptomic and Genomic Analysis Provides New Insights about Luminal Breast Cancers

PubMed Central

Tishchenko, Inna; Milioli, Heloisa Helena; Riveros, Carlos; Moscato, Pablo

2016-01-01

Despite constituting approximately two thirds of all breast cancers, the luminal A and B tumours are poorly classified at both clinical and molecular levels. There are contradictory reports on the nature of these subtypes: some define them as intrinsic entities, others as a continuum. With the aim of addressing these uncertainties and identifying molecular signatures of patients at risk, we conducted a comprehensive transcriptomic and genomic analysis of 2,425 luminal breast cancer samples. Our results indicate that the separation between the molecular luminal A and B subtypes—per definition—is not associated with intrinsic characteristics evident in the differentiation between other subtypes. Moreover, t-SNE and MST-kNN clustering approaches based on 10,000 probes, associated with luminal tumour initiation and/or development, revealed the close connections between luminal A and B tumours, with no evidence of a clear boundary between them. Thus, we considered all luminal tumours as a single heterogeneous group for analysis purposes. We first stratified luminal tumours into two distinct groups by their HER2 gene cluster co-expression: HER2-amplified luminal and ordinary-luminal. The former group is associated with distinct transcriptomic and genomic profiles, and poor prognosis; it comprises approximately 8% of all luminal cases. For the remaining ordinary-luminal tumours we further identified the molecular signature correlated with disease outcomes, exhibiting an approximately continuous gene expression range from low to high risk. Thus, we employed four virtual quantiles to segregate the groups of patients. The clinico-pathological characteristics and ratios of genomic aberrations are concordant with the variations in gene expression profiles, hinting at a progressive staging. The comparison with the current separation into luminal A and B subtypes revealed a substantially improved survival stratification. Concluding, we suggest a review of the definition of luminal A and B subtypes. A proposition for a revisited delineation is provided in this study. PMID:27341628

Sign luminance requirements for various background complexities

DOT National Transportation Integrated Search

1985-09-01

The Federal standards (FP-79) for luminance of retroreflective materials for traffic signs are acceptance standards; they provide no differentiation based on driver need. Driver needs for sign luminance are of 3 types -- luminance for sign comprehens...

Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations

PubMed Central

1993-01-01

The sarcoplasmic reticulum Ca(2+)-release channel plays a central role in cardiac muscle function by providing a ligand-regulated pathway for the release of sequestered Ca2+ to initiate contraction following cell excitation. The efficiency of the channel as a Ca(2+)-release pathway will be influenced by both gating and conductance properties of the system. In the past we have investigated conduction and discrimination of inorganic mono- and divalent cations with the aim of describing the mechanisms governing ion handling in the channel (Tinker, A., A.R. G. Lindsay, and A.J. Williams. 1992. Journal of General Physiology. 100:495-517.). In the present study, we have used permeant and impermeant organic cations to provide additional information on structural features of the conduction pathway. The use of permeant organic cations in biological channels to explore structural motifs underlying selectivity has been an important tool for the electrophysiologist. We have examined the conduction properties of a series of monovalent organic cations of varying size in the purified sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel. Relative permeability, determined from the reversal potential measured under bi- ionic conditions with 210-mM test cation at the cytoplasmic face of the channel and 210 mM K+ at the luminal, was related inversely to the minimum circular cation radius. The reversal potential was concentration-independent. The excluded area hypothesis, with and without a term for solute-wall friction, described the data well and gave a lower estimate for minimum pore radius of 3.3-3.5 A. Blocking studies with the impermeant charged derivative of triethylamine reveal that this narrowing occurs over the first 10-20% of the voltage drop when crossing from the lumen of the SR to the cytoplasm. Single-channel conductances were measured in symmetrical 210 mM salt. Factors other than relative permeability determine conductance as ions with similar relative permeability can have widely varying single-channel conductance. Permeant ions, such as the charged derivatives of trimethylamine and diethylmethylamine, can also inhibit K+ current. The reduction in relative conductance with increasing concentrations of these two ions at a holding potential of 60 mV was described by a rectangular hyperbola and revealed higher affinity binding for diethylmethylamine as compared to trimethylamine. It was possible to describe the complex permeation properties of these two ions using a single-ion four barrier, three binding site Eyring rate theory model. In conclusion, these studies reveal that the cardiac Ca(2+)-release channel has a selectivity filter of approximately 3.5-A radius located at the luminal face of the protein.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:8133241

Reference frames for spatial frequency in face representation differ in the temporal visual cortex and amygdala.

PubMed

Inagaki, Mikio; Fujita, Ichiro

2011-07-13

Social communication in nonhuman primates and humans is strongly affected by facial information from other individuals. Many cortical and subcortical brain areas are known to be involved in processing facial information. However, how the neural representation of faces differs across different brain areas remains unclear. Here, we demonstrate that the reference frame for spatial frequency (SF) tuning of face-responsive neurons differs in the temporal visual cortex and amygdala in monkeys. Consistent with psychophysical properties for face recognition, temporal cortex neurons were tuned to image-based SFs (cycles/image) and showed viewing distance-invariant representation of face patterns. On the other hand, many amygdala neurons were influenced by retina-based SFs (cycles/degree), a characteristic that is useful for social distance computation. The two brain areas also differed in the luminance contrast sensitivity of face-responsive neurons; amygdala neurons sharply reduced their responses to low luminance contrast images, while temporal cortex neurons maintained the level of their responses. From these results, we conclude that different types of visual processing in the temporal visual cortex and the amygdala contribute to the construction of the neural representations of faces.

Gender differences of airway dimensions in anatomically matched sites on CT in smokers.

PubMed

Kim, Yu-Il; Schroeder, Joyce; Lynch, David; Newell, John; Make, Barry; Friedlander, Adam; Estépar, Raúl San José; Hanania, Nicola A; Washko, George; Murphy, James R; Wilson, Carla; Hokanson, John E; Zach, Jordan; Butterfield, Kiel; Bowler, Russell P; Copdgene Investigators

2011-08-01

There are limited data on, and controversies regarding gender differences in the airway dimensions of smokers. Multi-detector CT (MDCT) images were analyzed to examine whether gender could explain differences in airway dimensions of anatomically matched airways in smokers. We used VIDA imaging software to analyze MDCT scans from 2047 smokers (M:F, 1021:1026) from the COPDGene® cohort. The airway dimensions were analyzed from segmental to subsubsegmental bronchi. We compared the differences of luminal area, inner diameter, wall thickness, wall area percentage (WA%) for each airway between men and women, and multiple linear regression including covariates (age, gender, body sizes, and other relevant confounding factors) was used to determine the predictors of each airway dimensions. Lumen area, internal diameter and wall thickness were smaller for women than men in all measured airway (18.4 vs 22.5 mm(2) for segmental bronchial lumen area, 10.4 vs 12.5 mm(2) for subsegmental bronchi, 6.5 vs 7.7 mm(2) for subsubsegmental bronchi, respectively p < 0.001). However, women had greater WA% in subsegmental and subsubsegmental bronchi. In multivariate regression, gender remained one of the most significant predictors of WA%, lumen area, inner diameter and wall thickness. Women smokers have higher WA%, but lower luminal area, internal diameter and airway thickness in anatomically matched airways as measured by CT scan than do male smokers. This difference may explain, in part, gender differences in the prevalence of COPD and airflow limitation.

Does Stevens's Power Law for Brightness Extend to Perceptual Brightness Averaging?

ERIC Educational Resources Information Center

Bauer, Ben

2009-01-01

Stevens's power law ([Psi][infinity][Phi][beta]) captures the relationship between physical ([Phi]) and perceived ([Psi]) magnitude for many stimulus continua (e.g., luminance and brightness, weight and heaviness, area and size). The exponent ([beta]) indicates whether perceptual magnitude grows more slowly than physical magnitude ([beta] less…

Vasoconstrictive responses of the testicular and caudal arteries in bulls exposed to ergot alkaloids from tall fescue

USDA-ARS?s Scientific Manuscript database

Color Doppler ultasonography was used to evaluate vasoconstrictive responses of the testicular artery in yearling bulls to ergot alkaloids. Ergot alkaloid-induced constriction of the testicular artery could disrupt thermoregulation of the testes and reduce bull fertility. Luminal areas of the test...

Minimizing the area required for time constants in integrated circuits

NASA Technical Reports Server (NTRS)

Lyons, J. C.

1972-01-01

When a medium- or large-scale integrated circuit is designed, efforts are usually made to avoid the use of resistor-capacitor time constant generators. The capacitor needed for this circuit usually takes up more surface area on the chip than several resistors and transistors. When the use of this network is unavoidable, the designer usually makes an effort to see that the choice of resistor and capacitor combinations is such that a minimum amount of surface area is consumed. The optimum ratio of resistance to capacitance that will result in this minimum area is equal to the ratio of resistance to capacitance which may be obtained from a unit of surface area for the particular process being used. The minimum area required is a function of the square root of the reciprocal of the products of the resistance and capacitance per unit area. This minimum occurs when the area required by the resistor is equal to the area required by the capacitor.

The perceptual consequences of interocular suppression in amblyopia.

PubMed

Maehara, Goro; Thompson, Benjamin; Mansouri, Behzad; Farivar, Reza; Hess, Robert F

2011-11-21

It is known that information from an amblyopic eye can be strongly suppressed when both eyes are open. The authors investigated the way in which suppression influences the relative perception of suprathreshold contrast and luminance between a person's eyes under dichoptic viewing conditions. Stimuli consisted of four patches of luminance or four patches containing gratings. Two patches were presented to each eye. Ten amblyopes with mild suppression (six strabismic, three anisometropic and strabismic, and one deprivation; mean age, 34.5 years) and three control observers with normal vision (mean age, 33.0 years) matched the appearance of the stimuli presented to each eye. The match involved manipulation of either luminance or contrast. Amblyopes with mild suppression decreased stimulus luminance in the fellow fixing eye or increased luminance in the amblyopic eye to achieve a match (mean matching luminance, 21.1 and 39.6 cd/m(2) for the fellow fixing eye and the amblyopic eye, respectively; standard luminance, 30 cd/m(2)). This interocular mismatch was also observed when luminance was variable and contrast was kept constant (mean matching luminance, 22.8 cd/m(2) for the fellow fixing eye). On the other hand, the amblyopic eye showed no loss of perceived contrast. There was little or no mismatch between the two eyes of control participants with normal binocular vision. Amblyopes have monocular deficits in contrast perception but dichoptic deficits in luminance perception, suggesting that suppression in its mild form involves luminance processing.

Luminance cues constrain chromatic blur discrimination in natural scene stimuli.

PubMed

Sharman, Rebecca J; McGraw, Paul V; Peirce, Jonathan W

2013-03-22

Introducing blur into the color components of a natural scene has very little effect on its percept, whereas blur introduced into the luminance component is very noticeable. Here we quantify the dominance of luminance information in blur detection and examine a number of potential causes. We show that the interaction between chromatic and luminance information is not explained by reduced acuity or spatial resolution limitations for chromatic cues, the effective contrast of the luminance cue, or chromatic and achromatic statistical regularities in the images. Regardless of the quality of chromatic information, the visual system gives primacy to luminance signals when determining edge location. In natural viewing, luminance information appears to be specialized for detecting object boundaries while chromatic information may be used to determine surface properties.

Chromatic blur perception in the presence of luminance contrast.

PubMed

Jennings, Ben J; Kingdom, Frederick A A

2017-06-01

Hel-Or showed that blurring the chromatic but not the luminance layer of an image of a natural scene failed to elicit any impression of blur. Subsequent studies have suggested that this effect is due either to chromatic blur being masked by spatially contiguous luminance edges in the scene (Journal of Vision 13 (2013) 14), or to a relatively compressed transducer function for chromatic blur (Journal of Vision 15 (2015) 6). To test between the two explanations we conducted experiments using as stimuli both images of natural scenes as well as simple edges. First, we found that in color-and-luminance images of natural scenes more chromatic blur was needed to perceptually match a given level of blur in an isoluminant, i.e. colour-only scene. However, when the luminance layer in the scene was rotated relative to the chromatic layer, thus removing the colour-luminance edge correlations, the matched blur levels were near equal. Both results are consistent with Sharman et al.'s explanation. Second, when observers matched the blurs of luminance-only with isoluminant scenes, the matched blurs were equal, against Kingdom et al.'s prediction. Third, we measured the perceived blur in a square-wave as a function of (i) contrast (ii) number of luminance edges and (iii) the relative spatial phase between the colour and luminance edges. We found that the perceived chromatic blur was dependent on both relative phase and the number of luminance edges, or dependent on the luminance contrast if only a single edge is present. We conclude that this Hel-Or effect is largely due to masking of chromatic blur by spatially contiguous luminance edges. Copyright © 2017 Elsevier Ltd. All rights reserved.

Photometric Compliance of Tablet Screens and Retro-Illuminated Acuity Charts As Visual Acuity Measurement Devices.

PubMed

Livingstone, I A T; Tarbert, C M; Giardini, M E; Bastawrous, A; Middleton, D; Hamilton, R

2016-01-01

Mobile technology is increasingly used to measure visual acuity. Standards for chart-based acuity tests specify photometric requirements for luminance, optotype contrast and luminance uniformity. Manufacturers provide some photometric data but little is known about tablet performance for visual acuity testing. This study photometrically characterised seven tablet computers (iPad, Apple inc.) and three ETDRS (Early Treatment Diabetic Retinopathy Study) visual acuity charts with room lights on and off, and compared findings with visual acuity measurement standards. Tablet screen luminance and contrast were measured using nine points across a black and white checkerboard test screen at five arbitrary brightness levels. ETDRS optotypes and adjacent white background luminance and contrast were measured. All seven tablets (room lights off) exceeded the most stringent requirement for mean luminance (≥ 120 cd/m2) providing the nominal brightness setting was above 50%. All exceeded contrast requirement (Weber ≥ 90%) regardless of brightness setting, and five were marginally below the required luminance uniformity threshold (Lmin/Lmax ≥ 80%). Re-assessing three tablets with room lights on made little difference to mean luminance or contrast, and improved luminance uniformity to exceed the threshold. The three EDTRS charts (room lights off) had adequate mean luminance (≥ 120 cd/m2) and Weber contrast (≥ 90%), but all three charts failed to meet the luminance uniformity standard (Lmin/Lmax ≥ 80%). Two charts were operating beyond manufacturer's recommended lamp replacement schedule. With room lights on, chart mean luminance and Weber contrast increased, but two charts still had inadequate luminance uniformity. Tablet computers showed less inter-device variability, higher contrast, and better luminance uniformity than charts in both lights-on and lights-off environments, providing brightness setting was >50%. Overall, iPad tablets matched or marginally out-performed ETDRS charts in terms of photometric compliance with high contrast acuity standards.

Photometric Compliance of Tablet Screens and Retro-Illuminated Acuity Charts As Visual Acuity Measurement Devices

PubMed Central

Livingstone, I. A. T.; Tarbert, C. M.; Giardini, M. E.; Bastawrous, A.; Middleton, D.; Hamilton, R.

2016-01-01

Mobile technology is increasingly used to measure visual acuity. Standards for chart-based acuity tests specify photometric requirements for luminance, optotype contrast and luminance uniformity. Manufacturers provide some photometric data but little is known about tablet performance for visual acuity testing. This study photometrically characterised seven tablet computers (iPad, Apple inc.) and three ETDRS (Early Treatment Diabetic Retinopathy Study) visual acuity charts with room lights on and off, and compared findings with visual acuity measurement standards. Tablet screen luminance and contrast were measured using nine points across a black and white checkerboard test screen at five arbitrary brightness levels. ETDRS optotypes and adjacent white background luminance and contrast were measured. All seven tablets (room lights off) exceeded the most stringent requirement for mean luminance (≥ 120 cd/m2) providing the nominal brightness setting was above 50%. All exceeded contrast requirement (Weber ≥ 90%) regardless of brightness setting, and five were marginally below the required luminance uniformity threshold (Lmin/Lmax ≥ 80%). Re-assessing three tablets with room lights on made little difference to mean luminance or contrast, and improved luminance uniformity to exceed the threshold. The three EDTRS charts (room lights off) had adequate mean luminance (≥ 120 cd/m2) and Weber contrast (≥ 90%), but all three charts failed to meet the luminance uniformity standard (Lmin/Lmax ≥ 80%). Two charts were operating beyond manufacturer’s recommended lamp replacement schedule. With room lights on, chart mean luminance and Weber contrast increased, but two charts still had inadequate luminance uniformity. Tablet computers showed less inter-device variability, higher contrast, and better luminance uniformity than charts in both lights-on and lights-off environments, providing brightness setting was >50%. Overall, iPad tablets matched or marginally out-performed ETDRS charts in terms of photometric compliance with high contrast acuity standards. PMID:27002333

Conjunctions of colour, luminance and orientation: the role of colour and luminance contrast on saliency and proximity grouping in texture segregation.

PubMed

Leonards, U; Singer, W

2000-01-01

To examine whether perceptual grouping on the basis of orientation can be performed simultaneously with or only subsequently to grouping according to colour or luminance, we tested whether subjects are able to segregate arrays of texture elements that differ from surrounding elements by conjunctions of either (i) colour and orientation, or (ii) luminance contrast and orientation, or (iii) luminance contrast polarity and orientation. Subjects were able to use conjunctions between luminance and orientation for segregation but not conjunctions between colour or contrast polarity and orientation. Our results suggest that (i) in agreement with earlier findings, there seem to exist no specific conjunction detectors for colour and orientation or contrast polarity and orientation, and (ii) when orientation defined textures are to be distinguished by virtue of differences in luminance, colour, or contrast polarity, luminance provides a much stronger cue than colour or contrast polarity for saliency-based orientation grouping.

Neural mechanism for sensing fast motion in dim light.

PubMed

Li, Ran; Wang, Yi

2013-11-07

Luminance is a fundamental property of visual scenes. A population of neurons in primary visual cortex (V1) is sensitive to uniform luminance. In natural vision, however, the retinal image often changes rapidly. Consequently the luminance signals visual cells receive are transiently varying. How V1 neurons respond to such luminance changes is unknown. By applying large static uniform stimuli or grating stimuli altering at 25 Hz that resemble the rapid luminance changes in the environment, we show that approximately 40% V1 cells responded to rapid luminance changes of uniform stimuli. Most of them strongly preferred luminance decrements. Importantly, when tested with drifting gratings, the preferred speeds of these cells were significantly higher than cells responsive to static grating stimuli but not to uniform stimuli. This responsiveness can be accounted for by the preferences for low spatial frequencies and high temporal frequencies. These luminance-sensitive cells subserve the detection of fast motion under the conditions of dim illumination.

THE MULTI-WAVELENGTH EXTREME STARBURST SAMPLE OF LUMINOUS GALAXIES. I. SAMPLE CHARACTERISTICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laag, Edward; Croft, Steve; Canalizo, Gabriela

2010-12-15

This paper introduces the Multi-wavelength Extreme Starburst Sample (MESS), a new catalog of 138 star-forming galaxies (0.1 < z < 0.3) optically selected from the Sloan Digital Sky Survey using emission line strength diagnostics to have a high absolute star formation rate (SFR; minimum 11 M{sub sun} yr{sup -1} with median SFR {approx} 61 M{sub sun} yr{sup -1} based on a Kroupa initial mass function). The MESS was designed to complement samples of nearby star-forming galaxies such as the luminous infrared galaxies (LIRGs) and ultraviolet luminous galaxies (UVLGs). Observations using the Multi-band Imaging Photometer (24, 70, and 160 {mu}m channels)more » on the Spitzer Space Telescope indicate that the MESS galaxies have IR luminosities similar to those of LIRGs, with an estimated median L{sub TIR} {approx} 3 x 10{sup 11} L{sub sun}. The selection criteria for the MESS objects suggest they may be less obscured than typical far-IR-selected galaxies with similar estimated SFRs. Twenty out of 70 of the MESS objects detected in the Galaxy Evolution Explorer FUV band also appear to be UVLGs. We estimate the SFRs based directly on luminosities to determine the agreement for these methods in the MESS. We compare these estimates to the emission line strength technique, since the effective measurement of dust attenuation plays a central role in these methods. We apply an image stacking technique to the Very Large Array FIRST survey radio data to retrieve 1.4 GHz luminosity information for 3/4 of the sample covered by FIRST including sources too faint, and at too high a redshift, to be detected in FIRST. We also discuss the relationship between the MESS objects and samples selected through alternative criteria. Morphologies will be the subject of a forthcoming paper.« less

A prospective comparison of phakic collamer lenses and wavefront-optimized laser-assisted in situ keratomileusis for correction of myopia

PubMed Central

Parkhurst, Gregory D

2016-01-01

Purpose The aim of this study was to evaluate and compare night vision and low-luminance contrast sensitivity (CS) in patients undergoing implantation of phakic collamer lenses or wavefront-optimized laser-assisted in situ keratomileusis (LASIK). Patients and methods This is a nonrandomized, prospective study, in which 48 military personnel were recruited. Rabin Super Vision Test was used to compare the visual acuity and CS of Visian implantable collamer lens (ICL) and LASIK groups under normal and low light conditions, using a filter for simulated vision through night vision goggles. Results Preoperative mean spherical equivalent was −6.10 D in the ICL group and −6.04 D in the LASIK group (P=0.863). Three months postoperatively, super vision acuity (SVa), super vision acuity with (low-luminance) goggles (SVaG), super vision contrast (SVc), and super vision contrast with (low luminance) goggles (SVcG) significantly improved in the ICL and LASIK groups (P<0.001). Mean improvement in SVaG at 3 months postoperatively was statistically significantly greater in the ICL group than in the LASIK group (mean change [logarithm of the minimum angle of resolution, LogMAR]: ICL =−0.134, LASIK =−0.085; P=0.032). Mean improvements in SVc and SVcG were also statistically significantly greater in the ICL group than in the LASIK group (SVc mean change [logarithm of the CS, LogCS]: ICL =0.356, LASIK =0.209; P=0.018 and SVcG mean change [LogCS]: ICL =0.390, LASIK =0.259; P=0.024). Mean improvement in SVa at 3 months was comparable in both groups (P=0.154). Conclusion Simulated night vision improved with both ICL implantation and wavefront-optimized LASIK, but improvements were significantly greater with ICLs. These differences may be important in a military setting and may also affect satisfaction with civilian vision correction. PMID:27418804

A prospective comparison of phakic collamer lenses and wavefront-optimized laser-assisted in situ keratomileusis for correction of myopia.

PubMed

Parkhurst, Gregory D

2016-01-01

The aim of this study was to evaluate and compare night vision and low-luminance contrast sensitivity (CS) in patients undergoing implantation of phakic collamer lenses or wavefront-optimized laser-assisted in situ keratomileusis (LASIK). This is a nonrandomized, prospective study, in which 48 military personnel were recruited. Rabin Super Vision Test was used to compare the visual acuity and CS of Visian implantable collamer lens (ICL) and LASIK groups under normal and low light conditions, using a filter for simulated vision through night vision goggles. Preoperative mean spherical equivalent was -6.10 D in the ICL group and -6.04 D in the LASIK group (P=0.863). Three months postoperatively, super vision acuity (SVa), super vision acuity with (low-luminance) goggles (SVaG), super vision contrast (SVc), and super vision contrast with (low luminance) goggles (SVcG) significantly improved in the ICL and LASIK groups (P<0.001). Mean improvement in SVaG at 3 months postoperatively was statistically significantly greater in the ICL group than in the LASIK group (mean change [logarithm of the minimum angle of resolution, LogMAR]: ICL =-0.134, LASIK =-0.085; P=0.032). Mean improvements in SVc and SVcG were also statistically significantly greater in the ICL group than in the LASIK group (SVc mean change [logarithm of the CS, LogCS]: ICL =0.356, LASIK =0.209; P=0.018 and SVcG mean change [LogCS]: ICL =0.390, LASIK =0.259; P=0.024). Mean improvement in SVa at 3 months was comparable in both groups (P=0.154). Simulated night vision improved with both ICL implantation and wavefront-optimized LASIK, but improvements were significantly greater with ICLs. These differences may be important in a military setting and may also affect satisfaction with civilian vision correction.

Enteric luminous microflora of the pond-cultured milk fishChanos chanos (Forskal).

PubMed

Ramesh, A; Nandakumar, R; Venugopalan, V K

1986-06-01

Qualitative and quantitative investigations were made on the luminous bacteria associated with the gut of pond cultured milk fishChanos chanos. Significant differences in luminous bacterial numbers were found between gut and pond water and between gut and pond sediment, but not between pond water and sediment. No significant variation in luminous bacterial population among the gut regions was observed. The quantity of ingesta in the fish gut does not appear to influence the biomass of luminous bacteria.Vibrio harveyi andV. fischeri were the 2 most commonly encountered species, and of the 2 luminous species,V. harveyi was predominant.

The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Peng; Li, Jingzhi; Sha, Bingdong

2016-11-29

PERK is one of the major sensor proteins which can detect the protein-folding imbalance generated by endoplasmic reticulum (ER) stress. It remains unclear how the sensor protein PERK is activated by ER stress. It has been demonstrated that the PERK luminal domain can recognize and selectively interact with misfolded proteins but not native proteins. Moreover, the PERK luminal domain may function as a molecular chaperone to directly bind to and suppress the aggregation of a number of misfolded model proteins. The data strongly support the hypothesis that the PERK luminal domain can interact directly with misfolded proteins to induce ERmore » stress signaling. To illustrate the mechanism by which the PERK luminal domain interacts with misfolded proteins, the crystal structure of the human PERK luminal domain was determined to 3.2 Å resolution. Two dimers of the PERK luminal domain constitute a tetramer in the asymmetric unit. Superimposition of the PERK luminal domain molecules indicated that the β-sandwich domain could adopt multiple conformations. It is hypothesized that the PERK luminal domain may utilize its flexible β-sandwich domain to recognize and interact with a broad range of misfolded proteins.« less

The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins.

PubMed

Wang, Peng; Li, Jingzhi; Sha, Bingdong

2016-12-01

PERK is one of the major sensor proteins which can detect the protein-folding imbalance generated by endoplasmic reticulum (ER) stress. It remains unclear how the sensor protein PERK is activated by ER stress. It has been demonstrated that the PERK luminal domain can recognize and selectively interact with misfolded proteins but not native proteins. Moreover, the PERK luminal domain may function as a molecular chaperone to directly bind to and suppress the aggregation of a number of misfolded model proteins. The data strongly support the hypothesis that the PERK luminal domain can interact directly with misfolded proteins to induce ER stress signaling. To illustrate the mechanism by which the PERK luminal domain interacts with misfolded proteins, the crystal structure of the human PERK luminal domain was determined to 3.2 Å resolution. Two dimers of the PERK luminal domain constitute a tetramer in the asymmetric unit. Superimposition of the PERK luminal domain molecules indicated that the β-sandwich domain could adopt multiple conformations. It is hypothesized that the PERK luminal domain may utilize its flexible β-sandwich domain to recognize and interact with a broad range of misfolded proteins.

Discovery of a new bona fide luminous blue variable in Norma

NASA Astrophysics Data System (ADS)

Gvaramadze, V. V.; Kniazev, A. Y.; Berdnikov, L. N.

2015-12-01

We report the results of optical spectroscopy of the candidate evolved massive star MN44 revealed via detection of a circular shell with the Spitzer Space Telescope. First spectra taken in 2009 May-June showed the Balmer lines in emission as well as numerous emission lines of iron, which is typical of luminous blue variables (LBVs) near the visual maximum. New observations carried out in 2015 May-September detected significant changes in the spectrum, indicating that the star became hotter. We found that these changes are accompanied by significant brightness variability of MN44. In particular, the Ic-band brightness decreased by ≈ 1.6 mag during the last six years and after reaching its minimum in 2015 June has started to increase. Using archival data, we also found that the Ic-band brightness increased by ≈3 mag in ≈30 yr preceding our observations. MN44 therefore represents the 17th known example of the Galactic bona fide LBVs. We detected a nitrogen-rich knot to the north-west of the star, which might represent an interstellar cloudlet interacting with the circumstellar shell. We discuss a possible association between MN44 and the INTEGRAL transient source of hard X-ray emission IGR J16327-4940, implying that MN44 might be either a colliding-wind binary or a high-mass X-ray binary.

Optimization Strategies for Bruch's Membrane Opening Minimum Rim Area Calculation: Sequential versus Simultaneous Minimization.

PubMed

Enders, Philip; Adler, Werner; Schaub, Friederike; Hermann, Manuel M; Diestelhorst, Michael; Dietlein, Thomas; Cursiefen, Claus; Heindl, Ludwig M

2017-10-24

To compare a simultaneously optimized continuous minimum rim surface parameter between Bruch's membrane opening (BMO) and the internal limiting membrane to the standard sequential minimization used for calculating the BMO minimum rim area in spectral domain optical coherence tomography (SD-OCT). In this case-control, cross-sectional study, 704 eyes of 445 participants underwent SD-OCT of the optic nerve head (ONH), visual field testing, and clinical examination. Globally and clock-hour sector-wise optimized BMO-based minimum rim area was calculated independently. Outcome parameters included BMO-globally optimized minimum rim area (BMO-gMRA) and sector-wise optimized BMO-minimum rim area (BMO-MRA). BMO area was 1.89 ± 0.05 mm 2 . Mean global BMO-MRA was 0.97 ± 0.34 mm 2 , mean global BMO-gMRA was 1.01 ± 0.36 mm 2 . Both parameters correlated with r = 0.995 (P < 0.001); mean difference was 0.04 mm 2 (P < 0.001). In all sectors, parameters differed by 3.0-4.2%. In receiver operating characteristics, the calculated area under the curve (AUC) to differentiate glaucoma was 0.873 for BMO-MRA, compared to 0.866 for BMO-gMRA (P = 0.004). Among ONH sectors, the temporal inferior location showed the highest AUC. Optimization strategies to calculate BMO-based minimum rim area led to significantly different results. Imposing an additional adjacency constraint within calculation of BMO-MRA does not improve diagnostic power. Global and temporal inferior BMO-MRA performed best in differentiating glaucoma patients.

Assessment of atherosclerotic luminal narrowing of coronary arteries based on morphometrically generated visual guides.

PubMed

Barth, Rolf F; Kellough, David A; Allenby, Patricia; Blower, Luke E; Hammond, Scott H; Allenby, Greg M; Buja, L Maximilian

Determination of the degree of stenosis of atherosclerotic coronary arteries is an important part of postmortem examination of the heart, but, unfortunately, estimation of the degree of luminal narrowing can be imprecise and tends to be approximations. Visual guides can be useful to assess this, but earlier attempts to develop such guides did not employ digital technology. Using this approach, we have developed two computer-generated morphometric guides to estimate the degree of luminal narrowing of atherosclerotic coronary arteries. The first is based on symmetric or eccentric circular or crescentic narrowing of the vessel lumen and the second on either slit-like or irregularly shaped narrowing of the vessel lumens. Using the Aperio ScanScope XT at a magnification of 20× we created digital whole-slide images of 20 representative microscopic cross sections of the left anterior descending (LAD) coronary artery, stained with either hematoxylin and eosin (H&E) or Movat's pentachrome stain. These cross sections illustrated a variety of luminal profiles and degrees of stenosis. Three representative types of images were selected and a visual guide was constructed with Adobe Photoshop CS5. Using the "Scale" and "Measurement" tools, we created a series of representations of stenosis with luminal cross sections depicting 20%, 40%, 60%, 70%, 80%, and 90% occlusion of the LAD branch. Four pathologists independently reviewed and scored the degree of atherosclerotic luminal narrowing based on our visual guides. In addition, digital technology was employed to determine the degree of narrowing by measuring the cross-sectional area of the 20 microscopic sections of the vessels, first assuming no narrowing and then comparing this to the percent of narrowing determined by precise measurement. Two of the observers were very experienced general autopsy pathologists, one was a first-year pathology resident on his first rotation on the autopsy service, and the fourth observer was a highly experienced cardiovascular pathologist. Interobserver reliability was assessed by determination of the intraclass correlation coefficient. The degrees of agreement for two H&E- and Movat-stained sections of the LADs from each of 10 decedents were 0.874 and 0.899, respectively, indicating strong interobserver agreement. On the average, the mean visual scores were ~8% less than the morphometric assessment (52.7 vs. 60.2), respectively. The visual guides that we have generated for scoring atherosclerotic luminal narrowing of coronary arteries should be helpful for a broad group of pathologists, from beginning pathology residents to experienced cardiovascular pathologists. Copyright © 2017 Elsevier Inc. All rights reserved.

Sca-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential

PubMed Central

Kwon, Oh-Joon; Zhang, Li; Xin, Li

2016-01-01

Recent lineage tracing studies support the existence of prostate luminal progenitors that possess extensive regenerative capacity, but their identity remains unknown. We show that Sca-1 (Stem Cell Antigen-1) identifies a small population of murine prostate luminal cells that reside in the proximal prostatic ducts adjacent to the urethra. Sca-1+ luminal cells do not express Nkx3.1. They do not carry the secretory function, although they express the androgen receptor. These cells are enriched in the prostates of castrated mice. In the in vitro prostate organoid assay, a small fraction of the Sca-1+ luminal cells are capable of generating budding organoids that are morphologically distinct from those derived from other cell lineages. Histologically, this type of organoid is composed of multiple inner layers of luminal cells surrounded by multiple outer layers of basal cells. When passaged, these organoids retain their morphological and histological features. Finally, the Sca-1+ luminal cells are capable of forming small prostate glands containing both basal and luminal cells in an in vivo prostate regeneration assay. Collectively, our study establishes the androgen-independent and bipotent organoid-forming Sca-1+ luminal cells as a functionally distinct cellular entity. These cells may represent a putative luminal progenitor population and serve as a cellular origin for castration resistant prostate cancer. PMID:26418304

Standard deviation of luminance distribution affects lightness and pupillary response.

PubMed

Kanari, Kei; Kaneko, Hirohiko

2014-12-01

We examined whether the standard deviation (SD) of luminance distribution serves as information of illumination. We measured the lightness of a patch presented in the center of a scrambled-dot pattern while manipulating the SD of the luminance distribution. Results showed that lightness decreased as the SD of the surround stimulus increased. We also measured pupil diameter while viewing a similar stimulus. The pupil diameter decreased as the SD of luminance distribution of the stimuli increased. We confirmed that these results were not obtained because of the increase of the highest luminance in the stimulus. Furthermore, results of field measurements revealed a correlation between the SD of luminance distribution and illuminance in natural scenes. These results indicated that the visual system refers to the SD of the luminance distribution in the visual stimulus to estimate the scene illumination.

Open-source products for a lighting experiment device.

PubMed

Gildea, Kevin M; Milburn, Nelda

2014-12-01

The capabilities of open-source software and microcontrollers were used to construct a device for controlled lighting experiments. The device was designed to ascertain whether individuals with certain color vision deficiencies were able to discriminate between the red and white lights in fielded systems on the basis of luminous intensity. The device provided the ability to control the timing and duration of light-emitting diode (LED) and incandescent light stimulus presentations, to present the experimental sequence and verbal instructions automatically, to adjust LED and incandescent luminous intensity, and to display LED and incandescent lights with various spectral emissions. The lighting device could easily be adapted for experiments involving flashing or timed presentations of colored lights, or the components could be expanded to study areas such as threshold light perception and visual alerting systems.

SIX MORE QUASARS AT REDSHIFT 6 DISCOVERED BY THE CANADA-FRANCE HIGH-z QUASAR SURVEY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Willott, Chris J.; Crampton, David; Hutchings, John B.

2009-03-15

We present imaging and spectroscopic observations for six quasars at z {>=} 5.9 discovered by the Canada-France High-z Quasar Survey (CFHQS). The CFHQS contains subsurveys with a range of flux and area combinations to sample a wide range of quasar luminosities at z {approx} 6. The new quasars have luminosities 10-75 times lower than the most luminous Sloan Digital Sky Survey quasars at this redshift. The least luminous quasar, CFHQS J0216-0455 at z = 6.01, has absolute magnitude M {sub 1450} = -22.21, well below the likely break in the luminosity function. This quasar is not detected in a deepmore » XMM-Newton survey showing that optical selection is still a very efficient tool for finding high-redshift quasars.« less

High power LED standard light sources for photometric applications

NASA Astrophysics Data System (ADS)

Ivashin, Evgeniy; Ogarev, Sergey; Khlevnoy, Boris; Shirokov, Stanislav; Dobroserdov, Dmitry; Sapritsky, Victor

2018-02-01

High power LED light sources have been developed as possible new VNIIOFI standard sources for luminous intensity, luminous flux and colour measurements. Stability, repeatability and spatial uniformity of the sources were investigated and demonstrated high accuracy and homogeneity. The paper describes different tests on one of the manufactured sources. In the future, these LED light sources are planned to be used as standard luminous flux sources to transfer the units of luminous intensity and luminous flux from gonio-spectrometer to sphere-spectrometer.

Evaluation of True Power Luminous Efficiency from Experimental Luminance Values

NASA Astrophysics Data System (ADS)

Tsutsui, Tetsuo; Yamamato, Kounosuke

1999-05-01

A method for obtaining true external power luminous efficiencyfrom experimentally obtained luminance in organic light-emittingdiodes (LEDs) wasdemonstrated. Conventional two-layer organic LEDs with different electron-transport layer thicknesses wereprepared. Spatial distributions of emission intensities wereobserved. The large deviation in both emission spectra and spatialemission patterns were observed when the electron-transport layerthickness was varied. The deviation of emission patterns from thestandard Lambertian pattern was found to cause overestimations ofpower luminous efficiencies as large as 30%. A method for evaluatingcorrection factors was proposed.

Independence and interaction of luminance and chromatic contributions to spatial hyperacuity performance.

PubMed

Cooper, Bonnie; Lee, Barry B

2014-04-01

Here we test interactions of luminance and chromatic input to spatial hyperacuity mechanisms. First, we tested alignment of luminance and chromatic gratings matched or mismatched in contrast polarity or grating type. Thresholds with matched gratings were low while all mismatched pairs were elevated. Second, we determined alignment acuity as a function of luminance or chromatic contrast alone or in the presence of constant contrast components of the other type. For in-phase components, performance followed the envelope of the more sensitive mechanism. However, polarity reversals revealed an asymmetric effect for luminance and chromatic conditions, which suggested that luminance can override chromatic mechanisms in hyperacuity; we interpret these findings in the context of spatial mechanisms.

Lightness computation by the human visual system

NASA Astrophysics Data System (ADS)

Rudd, Michael E.

2017-05-01

A model of achromatic color computation by the human visual system is presented, which is shown to account in an exact quantitative way for a large body of appearance matching data collected with simple visual displays. The model equations are closely related to those of the original Retinex model of Land and McCann. However, the present model differs in important ways from Land and McCann's theory in that it invokes additional biological and perceptual mechanisms, including contrast gain control, different inherent neural gains for incremental, and decremental luminance steps, and two types of top-down influence on the perceptual weights applied to local luminance steps in the display: edge classification and spatial integration attentional windowing. Arguments are presented to support the claim that these various visual processes must be instantiated by a particular underlying neural architecture. By pointing to correspondences between the architecture of the model and findings from visual neurophysiology, this paper suggests that edge classification involves a top-down gating of neural edge responses in early visual cortex (cortical areas V1 and/or V2) while spatial integration windowing occurs in cortical area V4 or beyond.

Stability of the nine sky quality meters in the Dutch night sky brightness monitoring network.

PubMed

den Outer, Peter; Lolkema, Dorien; Haaima, Marty; van der Hoff, Rene; Spoelstra, Henk; Schmidt, Wim

2015-04-22

In the context of monitoring abundance of artificial light at night, the year-to-year stability of Sky Quality Meters (SQMs) is investigated by analysing intercalibrations derived from two measurement campaigns that were held in 2011 and 2012. An intercalibration comprises a light sensitivity factor and an offset for each SQM. The campaigns were concerned with monitoring measurements, each lasting one month. Nine SQMs, together forming the Night Sky Brightness Monitoring network (MHN) in The Netherlands, were involved in both campaigns. The stability of the intercalibration of these instruments leads to a year-to-year uncertainty (standard deviation) of 5% in the measured median luminance occurring at the MHN monitoring locations. For the 10-percentiles and 90-percentiles, we find 8% and 4%, respectively. This means that, for urban and industrial areas, changes in the sky brightness larger than 5% become detectable. Rural and nature areas require an 8%-9% change of the median luminance to be detectable. The light sensitivety agrees within 8% for the whole group of SQMs.

Cloud Coverage Acts as an Amplifier for Ecological Light Pollution in Urban Ecosystems

PubMed Central

Kyba, Christopher C. M.; Ruhtz, Thomas; Fischer, Jürgen; Hölker, Franz

2011-01-01

The diurnal cycle of light and dark is one of the strongest environmental factors for life on Earth. Many species in both terrestrial and aquatic ecosystems use the level of ambient light to regulate their metabolism, growth, and behavior. The sky glow caused by artificial lighting from urban areas disrupts this natural cycle, and has been shown to impact the behavior of organisms, even many kilometers away from the light sources. It could be hypothesized that factors that increase the luminance of the sky amplify the degree of this “ecological light pollution”. We show that cloud coverage dramatically amplifies the sky luminance, by a factor of 10.1 for one location inside of Berlin and by a factor of 2.8 at 32 km from the city center. We also show that inside of the city overcast nights are brighter than clear rural moonlit nights, by a factor of 4.1. These results have important implications for choronobiological and chronoecological studies in urban areas, where this amplification effect has previously not been considered. PMID:21399694

Cloud coverage acts as an amplifier for ecological light pollution in urban ecosystems.

PubMed

Kyba, Christopher C M; Ruhtz, Thomas; Fischer, Jürgen; Hölker, Franz

2011-03-02

The diurnal cycle of light and dark is one of the strongest environmental factors for life on Earth. Many species in both terrestrial and aquatic ecosystems use the level of ambient light to regulate their metabolism, growth, and behavior. The sky glow caused by artificial lighting from urban areas disrupts this natural cycle, and has been shown to impact the behavior of organisms, even many kilometers away from the light sources. It could be hypothesized that factors that increase the luminance of the sky amplify the degree of this "ecological light pollution". We show that cloud coverage dramatically amplifies the sky luminance, by a factor of 10.1 for one location inside of Berlin and by a factor of 2.8 at 32 km from the city center. We also show that inside of the city overcast nights are brighter than clear rural moonlit nights, by a factor of 4.1. These results have important implications for choronobiological and chronoecological studies in urban areas, where this amplification effect has previously not been considered.

An unbiased measure of the contributions of chroma and luminance to saccadic suppression of displacement.

PubMed

Anand, Sulekha; Bridgeman, Bruce

2002-02-01

Perception of image displacement is suppressed during saccadic eye movements. We probed the source of saccadic suppression of displacement by testing whether it selectively affects chromatic- or luminance-based motion information. Human subjects viewed a stimulus in which chromatic and luminance cues provided conflicting information about displacement direction. Apparent motion occurred during either fixation or a 19.5 degree saccade. Subjects detected motion and discriminated displacement direction in each trial. They reported motion in over 90% of fixation trials and over 70% of saccade trials. During fixation, the probability of perceiving the direction carried by chromatic cues decreased as luminance contrast increased. During saccades, subjects tended to perceive the direction indicated by luminance cues when luminance contrast was high. However, when luminance contrast was low, subjects showed no preference for the chromatic- or luminance-based direction. Thus magnocellular channels are suppressed, while stimulation of parvocellular channels is below threshold, so that neither channel drives motion perception during saccades. These results confirm that magnocellular inhibition is the source of saccadic suppression.

Mismatched summation mechanisms in older adults for the perception of small moving stimuli.

PubMed

McDougall, Thomas J; Nguyen, Bao N; McKendrick, Allison M; Badcock, David R

2018-01-01

Previous studies have found evidence for reduced cortical inhibition in aging visual cortex. Reduced inhibition could plausibly increase the spatial area of excitation in receptive fields of older observers, as weaker inhibitory processes would allow the excitatory receptive field to dominate and be psychophysically measureable over larger areas. Here, we investigated aging effects on spatial summation of motion direction using the Battenberg summation method, which aims to control the influence of locally generated internal noise changes by holding overall display size constant. This method produces more accurate estimates of summation area than conventional methods that simply increase overall stimulus dimensions. Battenberg stimuli have a checkerboard arrangement, where check size (luminance-modulated drifting gratings alternating with mean luminance areas), but not display size, is varied and compared with performance for a full field stimulus to provide a measure of summation. Motion direction discrimination thresholds, where contrast was the dependent variable, were measured in 14 younger (24-34 years) and 14 older (62-76 years) adults. Older observers were less sensitive for all check sizes, but the relative sensitivity across sizes, also differed between groups. In the older adults, the full field stimulus offered smaller performance improvements compared to that for younger adults, specifically for the small checked Battenberg stimuli. This suggests aging impacts on short-range summation mechanisms, potentially underpinned by larger summation areas for the perception of small moving stimuli. Copyright © 2017 Elsevier Ltd. All rights reserved.

An assessment of the performance and quality control procedures of PACS workstation monitors used in Irish radiology departments

NASA Astrophysics Data System (ADS)

Wade, Cherrie; Brennan, Patrick C.; Mc Entee, Mark F.

2005-04-01

Diagnostic efficacy in soft-copy reporting relies heavily on the quality of workstation monitors and an investigation performed in 2002 demonstrated that CRT monitors in Dublin imaging departments were not operating at optimal levels. The current work examines the performance of CRTs being used in Dublin and other parts of Ireland to establish if problems reported in the earlier work have been rectified. All hospitals performing soft-copy reporting for general radiology using CRTs were included in the work. Examination of ambient lighting, calibration of monitors and analysis of CRT performance using the SMPTE test pattern and a selection of the AAPM test images was performed. Maximum luminance, spatial uniformity of luminance, temporal luminance stability, gamma, geometry, sharpness, veiling glare and spatial resolution of each monitor was evaluated. Ambient lighting in all reporting areas was within recommended levels. All the monitors were calibrated appropriately and were performing at acceptable levels for maximum luminance and temporal stability and only one of the thirty-three investigated failed to reach the standard for spatial uniformity. In contrast a number of the CRTs investigated showed poor adherence to acceptable levels for geometrical distortions, veiling glare and spatial resolution all of which are important influencers of image quality. Gamma values also appeared to be low for a number of monitors but this interpretation is provisional and subject to the establishment of ratified guideline values. The results demonstrate that although some improvement on the previous situation is evident, greater adherence to acceptable levels is required for certain parameters.

Influence of defunctionalization and mechanical forces on intestinal epithelial wound healing

PubMed Central

Kovalenko, Pavlo L.; Flanigan, Thomas L.; Chaturvedi, Lakshmi

2012-01-01

The influence on mucosal healing of luminal nutrient flow and the forces it creates are poorly understood. We hypothesized that altered deformation and extracellular pressure mediate, in part, the effects of defunctionalization on mucosal healing. We created patent or partially obstructing defunctionalizing jejunal Roux-en-Y anastomoses in rats to investigate mucosal healing in the absence or presence of luminal nutrient flow and measured luminal pressures to document partial obstruction. We used serosal acetic acid to induce ulcers in the proximal, distal, and defunctionalized intestinal segments. After 3 days, we assessed ulcer area, proliferation, and phosphorylated ERK. In vitro, we measured proliferation and migration in Caco-2 and IEC-6 intestinal epithelial cells subjected to cyclic strain, increased extracellular pressure, or strain and pressure together. Defunctionalization of intestine without obstruction reduced phosphorylated ERK, slowed ulcer healing, and inhibited mucosal proliferation. This outcome was blocked by PD-98059. Partial obstruction delayed ulcer healing but stimulated proliferation independently of ERK. In vitro, strain increased Caco-2 and IEC-6 proliferation and reduced migration across collagen but reduced proliferation and increased migration across fibronectin. In contrast, increased pressure and the combination of pressure and strain increased proliferation and reduced migration independently of substrate. PD-98059 reduced basal migration but increased migration under pressure. These results suggest that loss of the repetitive distension may decrease mucosal healing in defunctionalized bowel, while increased luminal pressure above anastomoses or in spastic bowel disease could further inhibit mucosal healing, despite peristaltic repetitive strain. ERK may mediate the effects of repetitive deformation but not the effects of pressure. PMID:22997197

Photo-Luminescent Targets in Space

NASA Technical Reports Server (NTRS)

Maida, James; Kolomenski, Andrei

2017-01-01

Photo-luminescent ("glow in the dark") products have seen a dramatic increase in performance is the last 15 years with the use of a strontium aluminate formulation. Because of this, ISS uses photo-luminescent markers for interior emergency egress guidance. The marker is COTS material composed of strontium aluminate doped with europium, imbedded in PVC and achieves a light emission performance rated at 600/90 (600 mcd at 10 minutes and 90 mcd at 1 hour, 2 mcd is minimum required for human visibility). The ICA goal is to determine this material's effectiveness for use externally on ISS and/or on visiting vehicles, when packaged in Lexan for UV protection. A thermal test was conducted by EC to characterize the luminance emission profile of the material at extreme cold and hot temperatures, such as experienced on ISS.

Use of green fluorescent protein to monitor Lactobacillus plantarum in the gastrointestinal tract of goats.

PubMed

Han, Xufeng; Wang, Lei; Li, Wei; Li, Bibo; Yang, Yuxin; Yan, Hailong; Qu, Lei; Chen, Yulin

2015-01-01

The experiment aimed to specifically monitor the passage of lactobacilli in vivo after oral administration. The green fluorescent protein (GFP) gene was cloned downstream from the constitutive p32 promoter from L. lactis subsp. cremoris Wg2. The recombinant expression vector, pLEM415-gfp-p32, was electroporated into Lactobacillus plantarum (L. plantarum) isolated from goat. Green fluorescent protein (GFP) was successfully expressed in L. plantarum. After 2 h post-administration, transformed Lactobacillus could be detectable in all luminal contents. In the rumen, bacteria concentration initially decreased, reached the minimum at 42 h post-oral administration and then increased. However, this concentration decreased constantly in the duodenum. This result indicated that L. plantarum could colonize in the rumen but not in the duodenum.

TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis.

PubMed

Cyr, A R; Kulak, M V; Park, J M; Bogachek, M V; Spanheimer, P M; Woodfield, G W; White-Baer, L S; O'Malley, Y Q; Sugg, S L; Olivier, A K; Zhang, W; Domann, F E; Weigel, R J

2015-01-22

Molecular subtypes of breast cancer are characterized by distinct patterns of gene expression that are predictive of outcome and response to therapy. The luminal breast cancer subtypes are defined by the expression of estrogen receptor-alpha (ERα)-associated genes, many of which are directly responsive to the transcription factor activator protein 2C (TFAP2C). TFAP2C participates in a gene regulatory network controlling cell growth and differentiation during ectodermal development and regulating ESR1/ERα and other luminal cell-associated genes in breast cancer. TFAP2C has been established as a prognostic factor in human breast cancer, however, its role in the establishment and maintenance of the luminal cell phenotype during carcinogenesis and mammary gland development have remained elusive. Herein, we demonstrate a critical role for TFAP2C in maintaining the luminal phenotype in human breast cancer and in influencing the luminal cell phenotype during normal mammary development. Knockdown of TFAP2C in luminal breast carcinoma cells induced epithelial-mesenchymal transition with morphological and phenotypic changes characterized by a loss of luminal-associated gene expression and a concomitant gain of basal-associated gene expression. Conditional knockout of the mouse homolog of TFAP2C, Tcfap2c, in mouse mammary epithelium driven by MMTV-Cre promoted aberrant growth of the mammary tree leading to a reduction in the CD24(hi)/CD49f(mid) luminal cell population and concomitant gain of the CD24(mid)/CD49f(hi) basal cell population at maturity. Our results establish TFAP2C as a key transcriptional regulator for maintaining the luminal phenotype in human breast carcinoma. Furthermore, Tcfap2c influences development of the luminal cell type during mammary development. The data suggest that TFAP2C has an important role in regulated luminal-specific genes and may be a viable therapeutic target in breast cancer.

Constancy of built-in luminance meter measurements in diagnostic displays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Silosky, M., E-mail: michael.silosky@ucdenver.edu; Marsh, R. M.

2013-12-15

Purpose: Liquid crystal displays used to interpret medical images are often equipped with built-in luminance meters to evaluate luminance response and Grayscale Standard Display Function conformance. This work evaluates agreement between luminance reported by the built-in meters and external measurements. Methods: The white level luminance was measured using a built-in meter and an external meter for 93 primary review workstations (Models MFGD 3420 and MDCG 3120-CB) with between 117 and 49 336 backlight hours (BLH). Measured luminance values were compared viat-test for displays with less than 25 000 BLH and those with more than 25 000 BLH. Bias between meters was also evaluated.more » Changes in luminance uniformity with increasing backlight hours were explored by determining the maximum luminance deviation (MLD) for subsets of these displays with less than 800 BLH and greater than 35 000 BLH. Results: The mean difference between built-in and external luminance measurements was 5.84% and 38.92% for displays with less than 25 000 and greater than 25 000 BLH, respectively, with a statistically significant difference in the means (p < 0.001). For displays with low BLH, a statistically significant bias was observed (p < 0.001) between built-in and external measurements. A high degree of correlation was observed between measurements made with two separate external meters (r = 0.999). The mean MLD was 9.5% and 11.2% for MDCG 3120-CB displays with less than 800 and greater than 35 000 BLH, respectively. The difference in the mean values was not statistically significant (p < 0.001). Conclusions: Disagreement between the white level luminance measured using the built-in and external meter increased with BLH. Consequently, reliance on values reported by the built-in luminance meter may result in a reduction in image contrast with time. Recommendations have been proposed regarding luminance response testing and corrective action for failing displays.« less

Effect of Background Luminance Level on the Assessment of Color Visual Acuity Using Colored Landolt Rings in Young Healthy Subjects.

PubMed

Tanaka, Yoshiki; Yokoyama, Sho; Horai, Rie; Kojima, Takashi; Hiroyuki, Sato; Kato, Yukihito; Takagi, Mari; Nakamura, Hideki; Tanaka, Kiyoshi; Ichikawa, Kazuo; Tanabe, Shoko

2018-03-01

To evaluate the color visual acuity (CVA) of young healthy subjects using colored Landolt rings and the effect of background luminance level on the CVA. We measured the CVA of 20 young healthy subjects (age: 23.8 ± 3.8 years) with different colors using a computer and a liquid crystal display, with 15 Landolt ring colors (30 cd/m 2 ) with a background luminance of 30 cd/m 2 , and then 100 cd/m 2 . We then used different background luminance levels (15-50 cd/m 2 ) using four Landolt ring colors (red, green-yellow, green, and blue-green) to evaluate the effect of the background luminance level on CVA. The CVA significantly differed among the colors with a background luminance of 30 cd/m 2 (p < 0.0001). Green-yellow and blue-purple had poor CVA (high LogMAR value; 0.808 ± 0.107 and 0.633 ± 0.150, respectively) with a background luminance of 30 cd/m 2 (same luminance as the Landolt rings). There were no significant differences in the CVAs among the colors with a background luminance of 100 cd/m 2 (p = 0.5999). There were no significant difference in the CVA between background luminance 30 cd/m 2 and other luminance level ranging from 28 to 32 cd/m 2 for colors of red, green-yellow, green, and blue-green. The results reveal that the background luminance of Landolt rings affects the CVA. Distinctive CVAs for each color are measured by equalizing the luminance between the Landolt ring and the background. We consider that the poor CVAs of these colors reflect the visual function of S-cone, because GY and BP are included in the confusion locus of tritan axis on the chromaticity diagram. We believe that CVA assessment may be useful for individuals who have known or suspected ocular dysfunction or color vision deficiencies.

The Extremely Luminous Quasar Survey (ELQS) in SDSS and the high-z bright-end Quasar Luminosity Function

NASA Astrophysics Data System (ADS)

Schindler, Jan-Torge; Fan, Xiaohui; McGreer, Ian

2018-01-01

Studies of the most luminous quasars at high redshift directly probe the evolution of the most massive black holes in the early Universe and their connection to massive galaxy formation. Unfortunately, extremely luminous quasars at high redshift are very rare objects. Only wide area surveys have a chance to constrain their population. The Sloan Digital Sky Survey (SDSS) nd the Baryon Oscillation Spectroscopic Survey (BOSS) have so far provided the most widely adopted measurements of the type I quasar luminosity function (QLF) at z>3. However, a careful re-examination of the SDSS quasar sample revealed that the SDSS quasar selection is in fact missing a significant fraction of $z~3$ quasars at the brightest end.We have identified the purely optical color selection of SDSS, where quasars at these redshifts are strongly contaminated by late-type dwarfs, and the spectroscopic incompleteness of the SDSS footprint as the main reasons. Therefore we have designed the Extremely Luminous Quasar Survey (ELQS), based on a novel near-infrared JKW2 color cut using WISE AllWISE and 2MASS all-sky photometry, to yield high completeness for very bright (i < 18.0) quasars in the redshift range of 2.8<= z<=5.0. It effectively uses Random Forest machine-learning algorithms on SDSS and WISE photometry for quasar-star classification and photometric redshift estimation.The ELQS is spectroscopically following up ~230 new quasar candidates in an area of ~12000 deg2 in the SDSS footprint, to obtain a well-defined and complete quasar sample for an accurate measurement of the bright-end quasar luminosity function (QLF) at 2.8<= z<=5.0. So far the ELQS has identified 75 bright new quasars in this redshift range and observations of the fall sky will continue until the end of the year. At the AAS winter meeting we will present the full spectroscopic results of the survey, including a re-estimation and extension of the high-z QLF toward higher luminosities.

ColorMoves: Optimizing Color's Potential for Exploration and Communication of Data

NASA Astrophysics Data System (ADS)

Samsel, F.

2017-12-01

Color is the most powerful perceptual channel available for exposing and communicating data. Most visualizations are rendered in one of a handful of common colormaps - the rainbow, cool-warm, heat map and viridis. These maps meet the basic criteria for encoding data - perceptual uniformity and reasonable discriminatory power. However, as the size and complexity of data grows, our need to optimize the potential of color grows. The ability to expose greater detail and differentiate between multiple variables becomes ever more important. To meet this need we have created ColorMoves, an interactive colormap construction tool that enables scientists to quickly and easily align a concentration contrast with the data ranges of interest. Perceptual research tells us that luminance is the strongest contrast and thus provides the highest degree of perceptual discrimination. However, the most commonly used colormaps contain a limited range of luminance contrast. ColorMoves enables interactive constructing colormaps enabling one to distribute the luminance where is it most needed. The interactive interface enables optimal placement of the color scales. The ability to watch the changes on ones data, in real time makes precision adjustment quick and easy. By enabling more precise placement and multiple ranges of luminance one can construct colomaps containing greater discriminatory power. By selecting from the wide range of color scale hues scientists can create colormaps intuitive to their subject. ColorMoves is comprised of four main components: a set of 40 color scales; a histogram of the data distribution; a viewing area showing the colormap on your data; and the controls section. The 40 color scales span the spectrum of hues, saturation levels and value distributions. The histogram of the data distribution enables placement of the color scales in precise locations. The viewing area show is the impact of changes on the data in real time. The controls section enables export of the constructed colormaps for use in tools such as ParaView and Matplotlib. For a clearer understanding of ColorMoves capability we recommend trying it out at SciVisColor.org.

Flicker sensitivity as a function of target area with and without temporal noise.

PubMed

Rovamo, J; Donner, K; Näsänen, R; Raninen, A

2000-01-01

Flicker sensitivities (1-30 Hz) in foveal, photopic vision were measured as functions of stimulus area with and without strong external white temporal noise. Stimuli were circular, sinusoidally flickering sharp-edged spots of variable diameters (0.25-4 degrees ) but constant duration (2 s), surrounded by a uniform equiluminant field. The data was described with a model comprising (i) low-pass filtering in the retina (R), with a modulation transfer function (MTF) of a form derived from responses of cones; (ii) normalisation of the temporal luminance distribution by the average luminance; (iii) high-pass filtering by postreceptoral neural pathways (P), with an MTF proportional to temporal frequency; (iv) addition of internal white neural noise (N(i)); (v) integration over a spatial window; and (vi) detection by a suboptimal temporal matched filter of efficiency eta. In strong external noise, flicker sensitivity was independent of spot area. Without external noise, sensitivity increased with the square root of stimulus area (Piper's law) up to a critical area (A(c)), where it reaches a maximum level (S(max)). Both A(c) and eta were monotonic functions of temporal frequency (f), such that log A(c) increased and log eta decreased linearly with log f. Remarkably, the increase in spatial integration area and the decrease in efficiency were just balanced, so A(c)(f)eta(f) was invariant against f. Thus the bandpass characteristics of S(max)(f) directly reflected the composite effect of the distal filters R(f) and P(f). The temporal equivalent (N(it)) of internal neural noise (N(i)) decreased in inverse proportion to spot area up to A(c) and then stayed constant indicating that spatially homogeneous signals and noise are integrated over the same area.

Luminance-model-based DCT quantization for color image compression

NASA Technical Reports Server (NTRS)

Ahumada, Albert J., Jr.; Peterson, Heidi A.

1992-01-01

A model is developed to approximate visibility thresholds for discrete cosine transform (DCT) coefficient quantization error based on the peak-to-peak luminance of the error image. Experimentally measured visibility thresholds for R, G, and B DCT basis functions can be predicted by a simple luminance-based detection model. This model allows DCT coefficient quantization matrices to be designed for display conditions other than those of the experimental measurements: other display luminances, other veiling luminances, and other spatial frequencies (different pixel spacings, viewing distances, and aspect ratios).

Let the sunshine in? The effects of luminance on economic preferences, choice consistency and dominance violations

PubMed Central

Glimcher, Paul W.

2017-01-01

Weather, in particular the intensity and duration of sunshine (luminance), has been shown to significantly affect financial markets. Yet, because of the complexity of market interactions we do not know how human behavior is affected by luminance in a way that could inform theoretical choice models. In this paper, we use data from a field study using an incentive-compatible, decision task conducted daily over a period of two years and from the US Earth System Research Laboratory luminance sensor to investigate the impact of luminance on risk preferences, ambiguity preferences, choice consistency and dominance violations. We find that luminance levels affect all of these. Age and gender influence the strength of some of these effects. PMID:28783734

Gender Differences of Airway Dimensions in Anatomically Matched Sites on CT in Smokers

PubMed Central

Kim, Yu-Il; Schroeder, Joyce; Lynch, David; Newell, John; Make, Barry; Friedlander, Adam; Estépar, Raúl San José; Hanania, Nicola A.; Washko, George; Murphy, James R.; Wilson, Carla; Hokanson, John E.; Zach, Jordan; Butterfield, Kiel; Bowler, Russell P.

2013-01-01

Rationale and Objectives There are limited data on, and controversies regarding gender differences in the airway dimensions of smokers. Multi-detector CT (MDCT) images were analyzed to examine whether gender could explain differences in airway dimensions of anatomically matched airways in smokers. Materials and Methods We used VIDA imaging software to analyze MDCT scans from 2047 smokers (M:F, 1021:1026) from the COPDGene® cohort. The airway dimensions were analyzed from segmental to subsubsegmental bronchi. We compared the differences of luminal area, inner diameter, wall thickness, wall area percentage (WA%) for each airway between men and women, and multiple linear regression including covariates (age, gender, body sizes, and other relevant confounding factors) was used to determine the predictors of each airway dimensions. Results Lumen area, internal diameter and wall thickness were smaller for women than men in all measured airway (18.4 vs 22.5 mm2 for segmental bronchial lumen area, 10.4 vs 12.5 mm2 for subsegmental bronchi, 6.5 vs 7.7 mm2 for subsubsegmental bronchi, respectively p < 0.001). However, women had greater WA% in subsegmental and subsubsegmental bronchi. In multivariate regression, gender remained one of the most significant predictors of WA%, lumen area, inner diameter and wall thickness. Conclusion Women smokers have higher WA%, but lower luminal area, internal diameter and airway thickness in anatomically matched airways as measured by CT scan than do male smokers. This difference may explain, in part, gender differences in the prevalence of COPD and airflow limitation. PMID:21756032

Performance of 'energy efficient' compact fluorescent lamps.

PubMed

Yuen, Gloria S-C; Sproul, Alistair B; Dain, Stephen J

2010-03-01

Compact fluorescent lamps (CFLs) have been heralded as highly energy efficient replacements for incandescent light globes, however, there is some public dissatisfaction with the light output and colour of CFLs. Independent examination of the claims made has not been made. Compliance with the interim Australian/New Zealand Standard has not been established by any independent authority. While the total light output (luminous flux) may meet certain standards, luminous intensity distributions of some designs do differ significantly from the incandescent sources that they are intended to replace. Luminous intensity distribution, luminous flux and spectral energy distribution of CFLs claimed to be equivalent to 75 W incandescent globes and 75 W incandescent globes (pearl and clear) were measured. Luminous flux, luminous efficacy, colour rendering index, correlated colour temperature, wattage and power factor were then calculated and compared with claims made by manufacturers and requirements of the standards. The sources generally complied with the requirements for luminous flux, luminous efficacy, colour rendering index and correlated colour temperature. The claim of 75 W equivalence, which is not regulated in Australia and New Zealand, is justified less than half the time. Luminous intensity distributions of biaxial CFLs are distinctly different from the incandescent lamps they purport to replace. CFLs generally comply with the standards set. The basis on which equivalent wattages are claimed needs to be included in the Australian and New Zealand standard because this is the measure most likely to be relied on by the public. Due to the differences in luminous intensity distribution, CFLs may not necessarily be a direct replacement for incandescent sources without some consideration.

On the Nature of the Prototype Luminous Blue Variable Ag Carinae. I. Fundamental Parameters During Visual Minimum Phases and Changes in the Bolometric Luminosity During the S-Dor Cycle

NASA Astrophysics Data System (ADS)

Groh, J. H.; Hillier, D. J.; Damineli, A.; Whitelock, P. A.; Marang, F.; Rossi, C.

2009-06-01

We present a detailed spectroscopic analysis of the luminous blue variable (LBV) AG Carinae (AG Car) during the last two visual minimum phases of its S-Dor cycle (1985-1990 and 2000-2003). The analysis reveals an overabundance of He, N, and Na, and a depletion of H, C, and O, on the surface of the AG Car, indicating the presence of a CNO-processed material. Furthermore, the ratio N/O is higher on the stellar surface than in the nebula. We found that the minimum phases of AG Car are not equal to each other, since we derived a noticeable difference between the maximum effective temperature achieved during 1985-1990 (22, 800 K) and 2000-2001 (17,000 K). Significant differences between the wind parameters in these two epochs were also noticed. While the wind terminal velocity was 300 km s-1 in 1985-1990, it was as low as 105 km s-1 in 2001. The mass-loss rate, however, was lower from 1985-1990 (1.5 × 10-5 M sun yr-1) than from 2000-2001 (3.7 × 10-5 M sun yr-1). We found that the wind of AG Car is significantly clumped (f sime 0.10-0.25) and that clumps must be formed deep in the wind. We derived a bolometric luminosity of 1.5 × 106 L sun during both minimum phases which, contrary to the common assumption, decreases to 1.0 × 106 L sun as the star moves toward the maximum flux in the V band. Assuming that the decrease in the bolometric luminosity of AG Car is due to the energy used to expand the outer layers of the star, we found that the expanding layers contain roughly 0.6-2 M sun. Such an amount of mass is an order of magnitude lower than the nebular mass around AG Car, but is comparable to the nebular mass found around lower-luminosity LBVs and to that of the Little Homunculus of Eta Car. If such a large amount of mass is indeed involved in the S Dor-type variability, we speculate that such instability could be a failed Giant Eruption, with several solar masses never becoming unbound from the star. Based on observations made with the 1.6 m telescope at the Observatório Pico dos Dias (OPD/LNA, Brazil), with the 1.52 m telescope and 8 m Very Large Telescope at the European Southern Observatory (ESO, Chile), with the International Ultraviolet Explorer (IUE) satellite, at the South African Astronomical Observatory (SAAO), and with the NASA-CNES-CSA Far Ultraviolet Spectroscopic Explorer (FUSE), which is operated for NASA by the Johns Hopkins University under NASA contract NAS5-32985.

An in vitro methodology for forecasting luminal concentrations and precipitation of highly permeable lipophilic weak bases in the fasted upper small intestine.

PubMed

Psachoulias, Dimitrios; Vertzoni, Maria; Butler, James; Busby, David; Symillides, Moira; Dressman, Jennifer; Reppas, Christos

2012-12-01

To develop an in vitro methodology for prediction of concentrations and potential precipitation of highly permeable, lipophilic weak bases in fasted upper small intestine based on ketoconazole and dipyridamole luminal data. Evaluate usefulness of methodology in predicting luminal precipitation of AZD0865 and SB705498 based on plasma data. A three-compartment in vitro setup was used. Depending on the dosage form administered in in vivo studies, a solution or a suspension was placed in the gastric compartment. A medium simulating the luminal environment (FaSSIF-V2plus) was initially placed in the duodenal compartment. Concentrated FaSSIF-V2plus was placed in the reservoir compartment. In vitro ketoconazole and dipyridamole concentrations and precipitated fractions adequately reflected luminal data. Unlike luminal precipitates, in vitro ketoconazole precipitates were crystalline. In vitro AZD0865 data confirmed previously published human pharmacokinetic data suggesting that absorption rates are not affected by luminal precipitation. In vitro SB705498 data predicted that significant luminal precipitation occurs after a 100 mg or 400 mg but not after a 10 mg dose, consistent with human pharmacokinetic data. An in vitro methodology for predicting concentrations and potential precipitation in fasted upper small intestine, after administration of highly permeable, lipophilic weak bases in fasted upper small intestine was developed and evaluated for its predictability in regard to luminal precipitation.

Environmental Assessment: Peterson AFB Military Housing Privatization Initiative, El Paso County, Colorado

DTIC Science & Technology

2006-06-08

would sublease the land from Peterson AFB, and would maintain and manage the housing area for a minimum of 723 military families for 50 years. Under...housing area for a minimum of 723 military families for 50 years. Under the no action alternative, the Air Force would not implement the MHPI at...Peterson AFB, and would maintain and manage the housing area for a minimum of 723 military families for 50 years. No Action Alternative Under the no

Integration of organic LEDs with inorganic LEDs for a hybrid lighting system

NASA Astrophysics Data System (ADS)

Kong, H. J.; Park, J. W.; Kim, Y. M.

2013-01-01

We demonstrate that a surface-emitting hybrid light source can be realized by a combination of organic and inorganic light-emitting devices (LEDs). To this end, a blue inorganic LED bar is deployed at one side of a transparent light guide plate (LGP), and a yellow organic LED (OLED) is in contact with the rear surface of the LGP. In such a configuration, it is found that the overall luminance is almost equivalent to the sum of the luminances measured from each light source, and the overall luminance uniformity is determined mainly by the luminance uniformity of the OLED panel at high luminances. We have achieved a white color showing the Commission Internationale d'Eclairage (CIE) chromaticity coordinates of (x = 0.34, y = 0.33), the power efficiency of 9.3 lm/W, the luminance uniformity of 63% at the luminance of 3100 cd m-2, the color rendering index as high as 89.3, and the correlated color temperature finely tunable within the range between 3000 and 8000 K. Such a system facilitates color tuning by adjusting their luminous intensities and hence the implementation of the emotional lighting system.

Esophageal luminal stenosis is an independent prognostic factor in esophageal squamous cell carcinoma.

PubMed

Yang, Yu-Shang; Hu, Wei-Peng; Ni, Peng-Zhi; Wang, Wen-Ping; Yuan, Yong; Chen, Long-Qi

2017-06-27

Predictive value of preoperative endoscopic characteristic of esophageal tumor has not been fully evaluated. The aim of this study is to investigate the impact of esophageal luminal stenosis on survival for patients with resectable esophageal squamous cell carcinoma (ESCC). The clinicopathologic characteristics of 623 ESCC patients who underwent curative resection as the primary treatment between January 2005 and April 2009 were retrospectively reviewed. The esophageal luminal stenosis measured by endoscopy was defined as a uniform measurement preoperatively. The impact of esophageal luminal stenosis on patients' overall survival (OS) and relation with other clinicopathological features were assessed. A Cox regression model was used to identify prognostic factors. The results showed that OS significantly decreased in patients with manifest stenotic tumor compared with patients without luminal obstruction (P<0.05). Considerable esophageal luminal stenosis was associated with a higher T stage, longer tumor length, and poorer differentiation (all P<0.05). In multivariate survival analysis, esophageal luminal stenosis remained as an independent prognostic factor for OS (P= 0.036). Esophageal luminal stenosis could have a significant impact on the OS in patients with resected ESCC and may provide additional prognostic value to the current staging system before any cancer-specific treatment.

20 CFR 654.407 - Housing.

Code of Federal Regulations, 2012 CFR

2012-04-01

... habitable room (not including partitioned areas) shall have at least one windown or skylight opening directly to the out-of-doors. The minimum total window or skylight area, including windows in doors, shall... percent of the minimum window or skylight area required, except where comparably adequate ventilation is...

20 CFR 654.407 - Housing.

Code of Federal Regulations, 2013 CFR

2013-04-01

... habitable room (not including partitioned areas) shall have at least one windown or skylight opening directly to the out-of-doors. The minimum total window or skylight area, including windows in doors, shall... percent of the minimum window or skylight area required, except where comparably adequate ventilation is...

Competition between color and luminance for target selection in smooth pursuit and saccadic eye movements.

PubMed

Spering, Miriam; Montagnini, Anna; Gegenfurtner, Karl R

2008-11-24

Visual processing of color and luminance for smooth pursuit and saccadic eye movements was investigated using a target selection paradigm. In two experiments, stimuli were varied along the dimensions color and luminance, and selection of the more salient target was compared in pursuit and saccades. Initial pursuit was biased in the direction of the luminance component whereas saccades showed a relative preference for color. An early pursuit response toward luminance was often reversed to color by a later saccade. Observers' perceptual judgments of stimulus salience, obtained in two control experiments, were clearly biased toward luminance. This choice bias in perceptual data implies that the initial short-latency pursuit response agrees with perceptual judgments. In contrast, saccades, which have a longer latency than pursuit, do not seem to follow the perceptual judgment of salience but instead show a stronger relative preference for color. These substantial differences in target selection imply that target selection processes for pursuit and saccadic eye movements use distinctly different weights for color and luminance stimuli.

Psychophysical and physiological responses to gratings with luminance and chromatic components of different spatial frequencies.

PubMed

Cooper, Bonnie; Sun, Hao; Lee, Barry B

2012-02-01

Gratings that contain luminance and chromatic components of different spatial frequencies were used to study the segregation of signals in luminance and chromatic pathways. Psychophysical detection and discrimination thresholds to these compound gratings, with luminance and chromatic components of the one either half or double the spatial frequency of the other, were measured in human observers. Spatial frequency tuning curves for detection of compound gratings followed the envelope of those for luminance and chromatic gratings. Different grating types were discriminable at detection threshold. Fourier analysis of physiological responses of macaque retinal ganglion cells to compound waveforms showed chromatic information to be restricted to the parvocellular pathway and luminance information to the magnocellular pathway. Taken together, the human psychophysical and macaque physiological data support the strict segregation of luminance and chromatic information in independent channels, with the magnocellular and parvocellular pathways, respectively, serving as likely the physiological substrates. © 2012 Optical Society of America

Color and luminance in the perception of 1- and 2-dimensional motion.

PubMed

Farell, B

1999-08-01

An isoluminant color grating usually appears to move more slowly than a luminance grating that has the same physical speed. Yet a grating defined by both color and luminance is seen as perceptually unified and moving at a single intermediate speed. In experiments measuring perceived speed and direction, it was found that color- and luminance-based motion signals are combined differently in the perception of 1-D motion than they are in the perception of 2-D motion. Adding color to a moving 1-D luminance pattern, a grating, slows its perceived speed. Adding color to a moving 2-D luminance pattern, a plaid made of orthogonal gratings, leaves its perceived speed unchanged. Analogous results occur for the perception of the direction of 2-D motion. The visual system appears to discount color when analyzing the motion of luminance-bearing 2-D patterns. This strategy has adaptive advantages, making the sensing of object motion more veridical without sacrificing the ability to see motion at isoluminance.

Luminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress.

PubMed

Hein, S M; Haricharan, S; Johnston, A N; Toneff, M J; Reddy, J P; Dong, J; Bu, W; Li, Y

2016-03-17

In the normal mammary gland, the basal epithelium is known to be bipotent and can generate either basal or luminal cells, whereas the luminal epithelium has not been demonstrated to contribute to the basal compartment in an intact and normally developed mammary gland. It is not clear whether cellular heterogeneity within a breast tumor results from transformation of bipotent basal cells or from transformation and subsequent basal conversion of the more differentiated luminal cells. Here we used a retroviral vector to express an oncogene specifically in a small number of the mammary luminal epithelial cells and tested their potential to produce basal cells during tumorigenesis. This in-vivo lineage-tracing work demonstrates that luminal cells are capable of producing basal cells on activation of either polyoma middle T antigen or ErbB2 signaling. These findings reveal the plasticity of the luminal compartment during tumorigenesis and provide an explanation for cellular heterogeneity within a cancer.

Luminal Epithelial Cells within the Mammary Gland Can Produce Basal Cells upon Oncogenic Stress

PubMed Central

Hein, Sarah M.; Haricharan, Svasti; Johnston, Alyssa N.; Toneff, Michael J.; Reddy, Jay P.; Dong, Jie; Bu, Wen; Li, Yi

2015-01-01

In the normal mammary gland, the basal epithelium is known to be bi-potent and can generate either basal or luminal cells, whereas the luminal epithelium has not been demonstrated to contribute to the basal compartment in an intact and normally developed mammary gland. It is not clear whether cellular heterogeneity within a breast tumor results from transformation of bi-potent basal cells or from transformation and subsequent basal conversion of the more differentiated luminal cells. Here, we used a retroviral vector to express an oncogene specifically in a small number of the mammary luminal epithelial cells and tested their potential to produce basal cells during tumorigenesis. This in vivo lineage tracing work demonstrates that luminal cells are capable of producing basal cells upon activation of either Polyoma Middle T antigen (PyMT) or ErbB2 signaling. These findings reveal the plasticity of the luminal compartment during tumorigenesis and provide an explanation for cellular heterogeneity within a cancer. PMID:26096929

20 CFR 654.407 - Housing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... directly to the out-of-doors. The minimum total window or skylight area, including windows in doors, shall... percent of the minimum window or skylight area required, except where comparably adequate ventilation is...

Single sensor processing to obtain high resolution color component signals

NASA Technical Reports Server (NTRS)

Glenn, William E. (Inventor)

2010-01-01

A method for generating color video signals representative of color images of a scene includes the following steps: focusing light from the scene on an electronic image sensor via a filter having a tri-color filter pattern; producing, from outputs of the sensor, first and second relatively low resolution luminance signals; producing, from outputs of the sensor, a relatively high resolution luminance signal; producing, from a ratio of the relatively high resolution luminance signal to the first relatively low resolution luminance signal, a high band luminance component signal; producing, from outputs of the sensor, relatively low resolution color component signals; and combining each of the relatively low resolution color component signals with the high band luminance component signal to obtain relatively high resolution color component signals.

An Initial Study of the Injection of an Intense Relativistic Electron Beam into the Atmosphere.

DTIC Science & Technology

1981-03-04

resolved spectroscopy , thermoluminescent x-ray detectors ( TLDs ), and Schlieren photography. The freely propagating electron beam produced a luminous region...atmosphere and its detection with a TLD ...................................... 17 VIII. REFERENCES...atmospheric even though such stu- dies have application in a number of important areas of research including electron beam sustained lasers , 9 inertial

Modulation of Cardiac Ryanodine Receptor Channels by Alkaline Earth Cations

PubMed Central

Diaz-Sylvester, Paula L.; Porta, Maura; Copello, Julio A.

2011-01-01

Cardiac ryanodine receptor (RyR2) function is modulated by Ca2+ and Mg2+. To better characterize Ca2+ and Mg2+ binding sites involved in RyR2 regulation, the effects of cytosolic and luminal earth alkaline divalent cations (M2+: Mg2+, Ca2+, Sr2+, Ba2+) were studied on RyR2 from pig ventricle reconstituted in bilayers. RyR2 were activated by M2+ binding to high affinity activating sites at the cytosolic channel surface, specific for Ca2+ or Sr2+. This activation was interfered by Mg2+ and Ba2+ acting at low affinity M2+-unspecific binding sites. When testing the effects of luminal M2+ as current carriers, all M2+ increased maximal RyR2 open probability (compared to Cs+), suggesting the existence of low affinity activating M2+-unspecific sites at the luminal surface. Responses to M2+ vary from channel to channel (heterogeneity). However, with luminal Ba2+or Mg2+, RyR2 were less sensitive to cytosolic Ca2+ and caffeine-mediated activation, openings were shorter and voltage-dependence was more marked (compared to RyR2 with luminal Ca2+or Sr2+). Kinetics of RyR2 with mixtures of luminal Ba2+/Ca2+ and additive action of luminal plus cytosolic Ba2+ or Mg2+ suggest luminal M2+ differentially act on luminal sites rather than accessing cytosolic sites through the pore. This suggests the presence of additional luminal activating Ca2+/Sr2+-specific sites, which stabilize high Po mode (less voltage-dependent) and increase RyR2 sensitivity to cytosolic Ca2+ activation. In summary, RyR2 luminal and cytosolic surfaces have at least two sets of M2+ binding sites (specific for Ca2+ and unspecific for Ca2+/Mg2+) that dynamically modulate channel activity and gating status, depending on SR voltage. PMID:22039534

EMBLA 2000: The Optical Mission

NASA Astrophysics Data System (ADS)

Teodorani, M.; Strand, E. P.; Hauge, B. G.

2001-10-01

In August 2001 a new joint collaboration between italian physicists and norwegian engineers was succesfully carried into effect with a new mission to Norway, in order to further investigate a luminous phenomenon which is occurring recurrently in the valley of Hessdalen. The italian research-activity of this year was concentrated in the acquisition of optical data coming from conventional photography, video imaging and video-spectroscopy. Many photographs, videos and some spectra were obtained of the phenomenon. The results coming from the subsequent analysis are synthetized in seven points. A) On the basis of a photometric (point spread function) and spectroscopic (low-resolution spectra) analysis, the luminous phenomenon results to be, in the very most part of the cases, a thermal plasma. From the maximum of the Planck curve a temperature T ~ 6500 deg K is measured, which remains approximately constant for all the duration of the luminous phenomenon (sometimes up to 3 minutes), in spite of the sharp luminosity variations. B) The light-phenomenon is subject to luminosity variations on a time-scale of the order of seconds and ten seconds. A light-curve shows characteristics of semi-pulsation (about ten seconds) of the `on-off' type in the primary phase, while in the secondary phase it presents a semi-stable behaviour which is settled at the maximum luminosity and with small semi-periodic oscillations (1 second). The luminosity maxima are reached only when the radiating surface reaches the largest dimensions, by remaining the flux approximately constant. C) The luminous phenomenon when seen by naked eye appears like `light orbs', while an instrumental analysis (both video and photographic) demonstrates that the light-orbs are often constituted of many smaller orbs which appear to vibrate around a common barycenter which coincides with a larger central body, and it is evident that the central body is sometimes able to eject smaller orbs on a time-scale of the order of 1 second. The increase of the radiating surface is often due to an integrated effect which is caused by the presence of many light-components which are occasionally located just outside of the central body. D) The luminous phenomenon is able to acquire any kind of shape, sometimes also sharply geometric. E) In spite of the fact that it looks like a thermal plasma, the luminous phenomenon doesn't present, from a thermodynamic point of view, any adiabatic behaviour. This is demonstrated by the missing of an anti-correlation between the diameter of the luminous body and the flux peak-value. F) A qualitative model is presented. It is hypothesized that the luminous orbs are thermal plasma structures which are triggered by a `central force' which simulates a mini-black hole and which are internally confined by a magnetic cage. The verified missing of heat production is hypothesized to be due to a blocking of the electrons of conduction. Other models, involving the presence of magnetic monopoles, and the photoionization of low-energy plasmas by cosmic rays, are considered too. G) Once more it has been possible to demonstrate that the Hessdalen area is also featured by other targets with anomalous characteristics which seem to overlap on the more `standard luminous phenomenon', from the analysis of two of which no plasma signature was found. One of these objects presents sharply `metal like' characteristics, whose appearance in the photo after a flash exposure is interpreted to be due to an effect of stimulated emission on a substance of semiconductive kind.

Optimal heliocentric trajectories for solar sail with minimum area

NASA Astrophysics Data System (ADS)

Petukhov, Vyacheslav G.

2018-05-01

The fixed-time heliocentric trajectory optimization problem is considered for planar solar sail with minimum area. Necessary optimality conditions are derived, a numerical method for solving the problem is developed, and numerical examples of optimal trajectories to Mars, Venus and Mercury are presented. The dependences of the minimum area of the solar sail from the date of departure from the Earth, the time of flight and the departing hyperbolic excess of velocity are analyzed. In particular, for the rendezvous problem (approaching a target planet with zero relative velocity) with zero departing hyperbolic excess of velocity for a flight duration of 1200 days it was found that the minimum area-to-mass ratio should be about 12 m2/kg for trajectory to Venus, 23.5 m2/kg for the trajectory to Mercury and 25 m2/kg for trajectory to Mars.

Plasmas in the atmosphere, tectonics and earthquake: a possible link for the crustal diagnosis?

NASA Astrophysics Data System (ADS)

Straser, V.

2017-12-01

An important aspect in the crustal surmise is the potential link between luminous phenomena and the earthquake . The study want to added data to this new geophysics concepts. The method is based on the comparison approach and consist in the data connection on a field in the area of Po Plain (Italy) with professional equipment: cameras, video cameras, spectroscopes, ELF / VLF receivers, Geiger counters and EM fields detectors. The Luminous phenomena sighting is compared 24/7 online with INGV and USGS database. The results show the formation of 2 types of plasma near the soil: Spheroidal shape, yellow-orange, constant brightness, sudden appearances, elevation from the ground between 10 ° -20 °, no noise, no wake emitted, estimated size about 2m, and duration of few seconds. Spheroidal shape, intense red fuzzy coloration, constant brightness, sudden appearances and fast movements in a linear fashion or slow movements, elevation from the ground between 2° to 7 °, no noise, no waves emitted, estimated dimensions over 2m, with a duration from a few seconds to a few minutes. We suppose that the formation of gas, also radioactive such as radon, and the electric charges necessary to trigger plasma, are related to the crustal stress. The rocks are exposed to important tectonics efforts and the outcome is the air ionizations near the soil that produce plasma if there are gas. The appearance of plasma forerun the earthquake that will happen some days later. The Anomalous Luminous phenomena may be related to tectonic activity, and the area of investigation can become a "lab" for research in Physics and Geology for the crustal diagnosis of pre-seismic phase.

Coronary anatomy in patients with various manifestations of three vessel coronary artery disease.

PubMed Central

Quyyumi, A A; Al-Rufaie, H K; Olsen, E G; Fox, K M

1985-01-01

The histology of coronary arteries was compared in patients with rest and effort angina. The arteries came from six patients with three vessel disease who died within four weeks of arteriography and ambulatory ST segment monitoring. Sections of all macroscopically visible arteries were taken every 5 mm and examined histologically. Episodes of ST segment depression had occurred on exertion in two patients, during exertion and rest (nocturnal) in two, and two patients had had no episodes of ST segment depression during ambulatory monitoring. Concentric (29%) or eccentric (62%) intimal thickening due to atheroma or fibroelastic tissue was found in 91% of sections. All but two normal intimal sections (1%) were found to be diseased in patients with ambulatory ST segment changes. Eccentric lesions with medial smooth muscle preservation in areas without intimal thickening, where further luminal narrowing could occur due to increases in smooth muscle tone, were found in 15% of sections. But these areas were not found in the proximal 3.5 cm of any of the major coronary arteries of the two patients with rest and effort ischaemia. Spasm could not have caused total occlusion in any of these arteries because the lumen was splinted by the lesion. There was no difference in mean luminal narrowing between patients with exertional and rest ischaemia and exertional ischaemia only (mean 74%), but mean luminal narrowing was lower in patients with no ambulatory episodes of ST segment change (39%). Thus medial smooth muscle spasm was unlikely to have caused occlusion in patients with ambulatory ST segment changes, although it could have altered lumen diameter. There are no histological differences in the coronary arteries of patients with rest or effort induced myocardial ischaemia. Images PMID:4052277

The effect of chromatic and luminance information on reaction times.

PubMed

O'Donell, Beatriz M; Barraza, Jose F; Colombo, Elisa M

2010-07-01

We present a series of experiments exploring the effect of chromaticity on reaction time (RT) for a variety of stimulus conditions, including chromatic and luminance contrast, luminance, and size. The chromaticity of these stimuli was varied along a series of vectors in color space that included the two chromatic-opponent-cone axes, a red-green (L-M) axis and a blue-yellow [S - (L + M)] axis, and intermediate noncardinal orientations, as well as the luminance axis (L + M). For Weber luminance contrasts above 10-20%, RTs tend to the same asymptote, irrespective of chromatic direction. At lower luminance contrast, the addition of chromatic information shortens the RT. RTs are strongly influenced by stimulus size when the chromatic stimulus is modulated along the [S - (L + M)] pathway and by stimulus size and adaptation luminance for the (L-M) pathway. RTs are independent of stimulus size for stimuli larger than 0.5 deg. Data are modeled with a modified version of Pieron's formula with an exponent close to 2, in which the stimulus intensity term is replaced by a factor that considers the relative effects of chromatic and achromatic information, as indexed by the RMS (square-root of the cone contrast) value at isoluminance and the Weber luminance contrast, respectively. The parameters of the model reveal how RT is linked to stimulus size, chromatic channels, and adaptation luminance and how they can be interpreted in terms of two chromatic mechanisms. This equation predicts that, for isoluminance, RTs for a stimulus lying on the S-cone pathway are higher than those for a stimulus lying on the L-M-cone pathway, for a given RMS cone contrast. The equation also predicts an asymptotic trend to the RT for an achromatic stimulus when the luminance contrast is sufficiently large.

Luminal angiotensin II stimulates rat medullary thick ascending limb chloride transport in the presence of basolateral norepinephrine.

PubMed

Baum, Michel

2016-02-15

Angiotensin II (ANG II) is secreted by the proximal tubule resulting in a luminal concentration that is 100- to 1,000-fold greater than that in the blood. Luminal ANG II has been shown to stimulate sodium transport in the proximal tubule and distal nephron. Surprisingly, luminal ANG II inhibits NaCl transport in the medullary thick ascending limb (mTAL), a nephron segment responsible for a significant amount of NaCl absorption from the glomerular ultrafiltrate. We confirmed that addition of 10(-8) M ANG II to the lumen inhibited mTAL chloride transport (220 ± 19 to 165 ± 25 pmol·mm(-1)·min(-1), P < 0.01) and examined whether an interaction with basolateral norepinephrine existed to simulate the in vivo condition of an innervated tubule. We found that in the presence of a 10(-6) M norepinephrine bath, luminal ANG II stimulated mTAL chloride transport from 298 ± 18 to 364 ± 42 pmol·mm(-1)·min(-1) (P < 0.05). Stimulation of chloride transport by luminal ANG II was also observed with 10(-3) M bath dibutyryl cAMP in the bathing solution and bath isoproterenol. A bath of 10(-5) H-89 blocked the stimulation of chloride transport by norepinephrine and prevented the effect of luminal ANG II to either stimulate or inhibit chloride transport. Bath phentolamine, an α-adrenergic agonist, also prevented the decrease in mTAL chloride transport by luminal ANG II. Thus luminal ANG II increases chloride transport with basolateral norepinephrine; an effect likely mediated by stimulation of cAMP. Alpha-1 adrenergic stimulation prevents the inhibition of chloride transport by luminal ANG II. Copyright © 2016 the American Physiological Society.

EQUILUMINANCE CELLS IN VISUAL CORTICAL AREA V4

PubMed Central

Bushnell, Brittany N.; Harding, Philip J.; Kosai, Yoshito; Bair, Wyeth; Pasupathy, Anitha

2011-01-01

We report a novel class of V4 neuron in the macaque monkey that responds selectively to equiluminant colored form. These "equiluminance" cells stand apart because they violate the well established trend throughout the visual system that responses are minimal at low luminance contrast and grow and saturate as contrast increases. Equiluminance cells, which compose about 22% of V4, exhibit the opposite behavior: responses are greatest near zero contrast and decrease as contrast increases. While equilumiance cells respond preferentially to equiluminant colored stimuli, strong hue tuning is not their distinguishing feature—some equilumiance cells do exhibit strong unimodal hue tuning but many show little or no tuning for hue. We find that equiluminance cells are color and shape selective to a degree comparable to other classes of V4 cells with more conventional contrast response functions. Those more conventional cells respond equally well to achromatic luminance and equiluminant color stimuli, analogous to color-luminance cells described in V1. The existence of equiluminance cells, which have not been reported in V1 or V2, suggests that chromatically-defined boundaries and shapes are given special status in V4 and raises the possibility that form at equiluminance and form at higher contrasts are processed in separate channels in V4. PMID:21880901

Hubble Space Telescope imaging of the central star forming region in NGC 1140 (exp 1)

NASA Technical Reports Server (NTRS)

Hunter, Deidre A.; O'Connell, Robert W.; Gallagher, John S. Iii

1994-01-01

We present broadband images taken with the Hubble Space Telescope's Planetary Camera of the central supergiant H II region in the amorphous galaxy NGC 1140. These images allow observations to a resolution of about 13 pc at the galaxy, and they reveal that its central 1/2 kpc contains 6-7 blue, luminous, compact super star clusters, many of which would be comparable in luminosity to globular clusters at the same age. A blue arc-shaped structure near the center may be a grouping of less luminous, R136/NGC 2070-sized clusters or a sheet of OB stars. Additional somewhat less luminous and redder clusters are also found farther out from the center. If these clusters are older, they too could have had luminosities comparable to those of the central six clusters at a comparable age. Thus, we find that NGC 1140 is remarkable in the number of extreme clusters that it has formed recently in a relatively small area of the galaxy. Since NGC 1140 exhibits global characteristics that are consistent with a recent merger, these clusters are likely to be a product of that event. This galaxy adds to the number of cases where rapid star formation has evidently produced super star clusters.

Quantitative ENT endoscopy: the future in the new millennium

NASA Astrophysics Data System (ADS)

Mueller, Andreas; Schubert, Mario

1999-06-01

In Otorhinolaryngology the endoscopic appraisal of luminal dimensions of the nose, the throat, the larynx and the trachea is a daily problem. Those concerned with endoscopy know, that endoscopes distort dimensions of examined anatomical structures. To draw conclusions on luminal dimensions from the endoscopic pictures additional measuring devices are required. We developed a new method of measuring luminal dimensions in rigid or flexible endoscopy. For this a laser beam directed radially marks the anatomical lumen of interest in the videoendoscopic vision. The laser ring becomes deformed according to the form of the cavity explored. By keeping the distance defined between the laser ring and the top of the endoscope, the endoscopic video image can be measured. A piece of software developed by us calculates from the pictures the cross sectional area as well as the extension of benign or malign stenosis of the cavity explored. The result of the endoscopic measuring procedure can be visualized 3D on a PC-monitor. We are going to demonstrate the result of our clinical experience in different otorhinolaryngological diseases with the new endoscopic measuring kit in comparison to standard endoscopy. A further perspective is the endoscopic measuring kit in comparison to standard endoscopy. A further perspective is the endoscopic assisted manufacturing (EAM) of anatomical adapted stents, tubes and cannules.

Improvement of the internal light environment on the objects of transport infrastructure with aid of sun-protective devices

NASA Astrophysics Data System (ADS)

Stetsky, Sergey

2017-10-01

The article analyzes the problems of outdoor stationary sun-protective devices (S.P.D.) and their influence on the natural daylighting levels in the premises of civil objects of transport infrastructure under the hot and sunny climatic conditions of the environment. It is noted, that with clear sky, typical for the said climate, non-uniform luminance of the sky differs seriously from the luminance of standard overcast sky with diffused light, recommended by C.I.E. (Commission International D’Eclairage).A conclusion is made, that with clear sky conditions, a sun-protective devices in the form of stationary canopies (awninas) help to improve the lighting environment in the premises considered. This becomes possible due to reflected sun flow from the surfaces of SPD employed, as well as due to rise of a daylight factor values in farmost from windows zones of interiors, because of the increase of luminance factor values of the sky areas, observed from these zones. Thus, the SPD considered, in the hot and sunny climatic conditions are able not only to carry out their main function of passive method of solar radiation and thermal control in the interiors, but also to act as an efficient measure to improve lightning environment of the premises in question.

Spatial Standard Observer

NASA Technical Reports Server (NTRS)

Watson, Andrw B. (Inventor)

2010-01-01

The present invention relates to devices and methods for the measurement and/or for the specification of the perceptual intensity of a visual image. or the perceptual distance between a pair of images. Grayscale test and reference images are processed to produce test and reference luminance images. A luminance filter function is convolved with the reference luminance image to produce a local mean luminance reference image . Test and reference contrast images are produced from the local mean luminance reference image and the test and reference luminance images respectively, followed by application of a contrast sensitivity filter. The resulting images are combined according to mathematical prescriptions to produce a Just Noticeable Difference, JND value, indicative of a Spatial Standard Observer. SSO. Some embodiments include masking functions. window functions. special treatment for images lying on or near border and pre-processing of test images.

Spatial Standard Observer

NASA Technical Reports Server (NTRS)

Watson, Andrew B. (Inventor)

2012-01-01

The present invention relates to devices and methods for the measurement and/or for the specification of the perceptual intensity of a visual image, or the perceptual distance between a pair of images. Grayscale test and reference images are processed to produce test and reference luminance images. A luminance filter function is convolved with the reference luminance image to produce a local mean luminance reference image. Test and reference contrast images are produced from the local mean luminance reference image and the test and reference luminance images respectively, followed by application of a contrast sensitivity filter. The resulting images are combined according to mathematical prescriptions to produce a Just Noticeable Difference, JND value, indicative of a Spatial Standard Observer, SSO. Some embodiments include masking functions, window functions, special treatment for images lying on or near borders and pre-processing of test images.

A Review of Research Related to Unmanned Aircraft System Visual Observers

DTIC Science & Technology

2014-10-01

accommodation. Poor Contrast Contrast refers to the difference in luminance between an object and its background. The larger the difference in luminance , the...to camouflage potential targets. Complex Backgrounds When the background behind an object contains a variety of luminance levels and contours it...itself contained a variety of luminance levels and contours. It is likely that this complex background effect would be seen more often between air

Research on effects of baffle position in an integrating sphere on the luminous flux measurement

NASA Astrophysics Data System (ADS)

Lin, Fangsheng; Li, Tiecheng; Yin, Dejin; Lai, Lei; Xia, Ming

2016-09-01

In the field of optical metrology, luminous flux is an important index to characterize the quality of electric light source. Currently, the majority of luminous flux measurement is based on the integrating sphere method, so measurement accuracy of integrating sphere is the key factor. There are plenty of factors affecting the measurement accuracy, such as coating, power and the position of light source. However, the baffle which is a key part of integrating sphere has important effects on the measurement results. The paper analyzes in detail the principle of an ideal integrating sphere. We use moving rail to change the relative position of baffle and light source inside the sphere. By experiments, measured luminous flux values at different distances between the light source and baffle are obtained, which we used to take analysis of the effects of different baffle position on the measurement. By theoretical calculation, computer simulation and experiment, we obtain the optimum position of baffle for luminous flux measurements. Based on the whole luminous flux measurement error analysis, we develop the methods and apparatus to improve the luminous flux measurement accuracy and reliability. It makes our unifying and transferring work of the luminous flux more accurate in East China and provides effective protection for our traceability system.

Esophageal luminal stenosis is an independent prognostic factor in esophageal squamous cell carcinoma

PubMed Central

Yang, Yu-Shang; Hu, Wei-Peng; Ni, Peng-Zhi; Wang, Wen-Ping; Yuan, Yong; Chen, Long-Qi

2017-01-01

Background Predictive value of preoperative endoscopic characteristic of esophageal tumor has not been fully evaluated. The aim of this study is to investigate the impact of esophageal luminal stenosis on survival for patients with resectable esophageal squamous cell carcinoma (ESCC). Methods The clinicopathologic characteristics of 623 ESCC patients who underwent curative resection as the primary treatment between January 2005 and April 2009 were retrospectively reviewed. The esophageal luminal stenosis measured by endoscopy was defined as a uniform measurement preoperatively. The impact of esophageal luminal stenosis on patients’ overall survival (OS) and relation with other clinicopathological features were assessed. A Cox regression model was used to identify prognostic factors. Results The results showed that OS significantly decreased in patients with manifest stenotic tumor compared with patients without luminal obstruction (P<0.05). Considerable esophageal luminal stenosis was associated with a higher T stage, longer tumor length, and poorer differentiation (all P<0.05). In multivariate survival analysis, esophageal luminal stenosis remained as an independent prognostic factor for OS (P= 0.036). Conclusions Esophageal luminal stenosis could have a significant impact on the OS in patients with resected ESCC and may provide additional prognostic value to the current staging system before any cancer-specific treatment. PMID:28118615

Chromatic signals control proboscis movements during hovering flight in the hummingbird hawkmoth Macroglossum stellatarum.

PubMed

Goyret, Joaquín; Kelber, Almut

2012-01-01

Most visual systems are more sensitive to luminance than to colour signals. Animals resolve finer spatial detail and temporal changes through achromatic signals than through chromatic ones. Probably, this explains that detection of small, distant, or moving objects is typically mediated through achromatic signals. Macroglossum stellatarum are fast flying nectarivorous hawkmoths that inspect flowers with their long proboscis while hovering. They can visually control this behaviour using floral markings known as nectar guides. Here, we investigate whether this is mediated by chromatic or achromatic cues. We evaluated proboscis placement, foraging efficiency, and inspection learning of naïve moths foraging on flower models with coloured markings that offered either chromatic, achromatic or both contrasts. Hummingbird hawkmoths could use either achromatic or chromatic signals to inspect models while hovering. We identified three, apparently independent, components controlling proboscis placement: After initial contact, 1) moths directed their probing towards the yellow colour irrespectively of luminance signals, suggesting a dominant role of chromatic signals; and 2) moths tended to probe mainly on the brighter areas of models that offered only achromatic signals. 3) During the establishment of the first contact, naïve moths showed a tendency to direct their proboscis towards the small floral marks independent of their colour or luminance. Moths learned to find nectar faster, but their foraging efficiency depended on the flower model they foraged on. Our results imply that M. stellatarum can perceive small patterns through colour vision. We discuss how the different informational contents of chromatic and luminance signals can be significant for the control of flower inspection, and visually guided behaviours in general.

Lasers' spectral and temporal profile can affect visual glare disability.

PubMed

Beer, Jeremy M A; Freeman, David A

2012-12-01

Experiments measured the effects of laser glare on visual orientation and motion perception. Laser stimuli were varied according to spectral composition and temporal presentation as subjects identified targets' tilt (Experiment 1) and movement (Experiment 2). The objective was to determine whether the glare parameters would alter visual disruption. Three spectral profiles (monochromatic Green vs. polychromatic White vs. alternating Red-Green) were used to produce a ring of laser glare surrounding a target. Two experiments were performed to measure the minimum contrast required to report target orientation or motion direction. The temporal glare profile was also varied: the ring was illuminated either continuously or discontinuously. Time-averaged luminance of the glare stimuli was matched across all conditions. In both experiments, threshold (deltaL) values were approximately 0.15 log units higher in monochromatic Green than in polychromatic White conditions. In Experiment 2 (motion identification), thresholds were approximately 0.17 log units higher in rapidly flashing (6, 10, or 14 Hz) than in continuous exposure conditions. Monochromatic extended-source laser glare disrupted orientation and motion identification more than polychromatic glare. In the motion task, pulse trains faster than 6 Hz (but below flicker fusion) elevated thresholds more than continuous glare with the same time-averaged luminance. Under these conditions, alternating the wavelength of monochromatic glare over time did not aggravate disability relative to green-only glare. Repetitively flashing monochromatic laser glare induced occasional episodes of impaired motion identification, perhaps resulting from cognitive interference. Interference speckle might play a role in aggravating monochromatic glare effects.

High-resolution magnetic resonance imaging of carotid atherosclerotic plaques - a correlation study with histopathology.

PubMed

Xia, Zhangyong; Yang, Hua; Yuan, Xiaochun; Wang, Jiyue; Zhang, Shigang; Zhang, Liyong; Qu, Yang; Chen, Jun; Jiao, Liqun; Wang, Le-Xin; Du, Yifeng

2017-07-01

This study aimed to utilize high-resolution magnetic resonance imaging (MRI) to investigate the characteristics of stable and vulnerable carotid arteriosclerotic plaques, with correlations to histopathological findings. High-resolution MRI was performed in 817 patients, using three-dimensional magnetic resonance angiography. Plaque composition was evaluated by measuring the areas occupied by calcification, a lipid-rich necrotic core, intra-plaque haemorrhage, and fibrous cap rupture. Plaque morphology was analysed by measuring vessel wall area, thickness, and luminal area at the bifurcation of the common carotid artery. Plaque tissues were sampled during carotid endarterectomy and examined using haematoxylin-eosin, Oil Red O, Masson trichrome staining, and immunohistochemical staining for CD68. Patients were divided into stable plaque group (n = 462) and vulnerable plaque group (n = 355), based on intraoperative observations and postoperative histopathological findings. Compared to the stable plaque group, the vulnerable plaque group exhibited increased vessel wall areas and thickness, and decreased mean luminal areas (P < 0.001). The vulnerable plaque group also had a lower collagen content, a higher lipid content, and higher CD68 expression in plaque tissues on histological examinations (P < 0.01). Incidences of lipid-rich necrotic core (38.1 % vs. 34.3 %), intra-plaque haemorrhage (26.9 % vs. 22.8 %), plaque calcification (45.2 % vs. 40.9 %), and fibrous cap rupture (36.0 % vs 39.8 %) in the plaques were concordant with MRI observations and histopathological findings (p > 0.05). Stable and vulnerable carotid plaques had different morphologies and compositions. High-resolution MRI can assess such differences qualitatively and quantitatively in vivo and provide guidance for risk stratification and management.

Analysis of Human Activities in Nature Reserves Based on Nighttime Light Remote Sensing and Microblogging Data - by the Case of National Nature Reserves in Jiangxi Province

NASA Astrophysics Data System (ADS)

Shi, F.; Li, X.; Xu, H.

2017-09-01

The study used the mainstream social media in china - Sina microblogging data combined with nighttime light remote sensing and various geographical data to reveal the pattern of human activities and light pollution of the Jiangxi Provincial National Nature Reserves. Firstly, we performed statistical analysis based on both functional areas and km-grid from the perspective of space and time, and selected the key areas for in-depth study. Secondly, the relationship between microblogging data and nighttime light remote sensing, population, GDP, road coverage, road distance and road type in nature reserves was analyzed by Spearman correlation coefficient method, so the distribution pattern and influencing factors of the microblogging data were explored. Thirdly, a region where the luminance value was greater than 0.2 was defined as a light region. We evaluated the management status by analyzing the distribution of microblogging data in both light area and non-light area. Final results showed that in all nature reserves, the top three were the Lushan Nature Reserve, the Jinggangshan Nature Reserve, the Taohongling National Nature Reserve of Sikas both on the total number and density of microblogging ; microblogging had a significant correlation with nighttime light remote sensing , the GDP, population, road and other factors; the distribution of microblogging near roads in protected area followed power laws; luminous radiance of Lushan Nature Reserve was the highest, with 43 percent of region was light at night; analysis combining nighttime light remote sensing with microblogging data reflected the status of management of nature reserves.

Spatial clustering and longitudinal variation of Anopheles darlingi (Diptera: Culicidae) larvae in a river of the Amazon: the importance of the forest fringe and of obstructions to flow in frontier malaria.

PubMed

Barros, F S M; Arruda, M E; Gurgel, H C; Honório, N A

2011-12-01

Deforestation has been linked to a rise in malaria prevalence. In this paper, we studied longitudinally 20 spots, including forested and deforested portions of a temporary river in a malarigenous frontier zone. Larval habitat parameters influencing distribution of Anopheles darlingi (Diptera: Culicidae) larvae were studied. We observed that larvae were clustered in forested-deforested transitions. For the first time in the literature, it was verified that parameters determining larval distribution varied from deforested to forested areas. The proximity to human dwellings was also a significant factor determining distribution, but larvae was most importantly associated with a previously undescribed parameter, the presence of small obstructions to river flow, such as tree trunks within the river channel, which caused pooling of water during the dry season ('microdams'). In deforested areas, the most important factor determining distribution of larvae was shade (reduced luminance). Larvae were absent in the entire studied area during the wet season and present in most sites during the dry season. During the wet-dry transition, larvae were found sooner in areas with microdams, than in other areas, suggesting that flow obstruction prolongs the breeding season of An. darlingi. Adult mosquito densities and malaria incidence were higher during the dry season. Our data correlate well with the published literature, including the distribution of malaria cases near the forest fringes, and has permitted the creation of a model of An. darlingi breeding, where preference for sites with reduced luminance, human presence and microdams would interact to determine larval distribution.

Advancing Our Understanding of the Etiologies and Mutational Landscapes of Basal-Like, Luminal A, and Luminal B Breast Cancers

DTIC Science & Technology

2017-10-01

study to identify how various breast cancer risk factors differ in their relationships to different molecular subtypes of breast cancer and to further...characterize molecular differences between these subtypes. To address the existing research gaps regarding the etiologies of different molecular ... molecular subtypes of breast cancer, basal-like, luminal A, and luminal B tumors, breast cancer risk factors 16. SECURITY CLASSIFICATION OF: 17

Advancing Our Understanding of the Etiologies and Mutational Landscapes of Basal-Like, Luminal A, and Luminal B Breast Cancers

DTIC Science & Technology

2017-10-01

various breast cancer risk factors differ in their relationships to different molecular subtypes of breast cancer and to further characterize... molecular differences between these subtypes. To address the existing research gaps regarding the etiologies of different molecular subtypes of breast... molecular subtypes of breast cancer, basal-like, luminal A, and luminal B tumors, breast cancer risk factors 16. SECURITY CLASSIFICATION OF: 17. LIMITATION

Trilateral Intercomparison of Photometric Units Maintained at NIST (USA), NPL (UK), and PTB (Germany)

PubMed Central

Ohno, Yoshi; Goodman, Teresa; Sauter, Georg

1999-01-01

A trilateral intercomparison of photometric units between NIST (USA), NPL (UK), and PTB (Germany) has been conducted to update the knowledge of the relationship between the photometric units disseminated in the three countries. The luminous intensity unit (cd), the luminous responsivity scale (A/lx), and the luminous flux unit (lm) maintained at each laboratory were compared by circulating transfer standard lamps and photometers. The results showed that the relative luminous intensity values, with respect to the average, measured by NIST, NPL, and PTB were 1.0014, 1.0021, and 0.9966; the relative inverse values of the luminous responsivity (corresponding to illuminance) were 1.0023, 1.0011, and 0.9965; the relative luminous flux values were 0.9994, 1.0034, and 0.9972, respectively. The results agreed within the stated uncertainties of the units maintained at the three laboratories.

Influence of high ambient illuminance and display luminance on readability and subjective preference

NASA Astrophysics Data System (ADS)

De Moor, Katrien; Andrén, Börje; Guo, Yi; Brunnström, Kjell; Wang, Kun; Drott, Anton; Hermann, David S.

2015-03-01

Many devices, such as tablets, smartphones, notebooks, fixed and portable navigation systems are used on a (nearly) daily basis, both in in- and outdoor environments. It is often argued that contextual factors, such as the ambient illuminance in relation to characteristics of the display (e.g., surface treatment, screen reflectance, display luminance …) may have a strong influence on the use of such devices and corresponding user experiences. However, the current understanding of these influence factors is still rather limited. In this work, we therefore focus in particular on the impact of lighting and display luminance on readability, visual performance, subjective experience and preference. A controlled lab study (N=18) with a within-subjects design was performed to evaluate two car displays (one glossy and one matte display) in conditions that simulate bright outdoor lighting conditions. Four ambient luminance levels and three display luminance settings were combined into 7 experimental conditions. More concretely, we investigated for each display: (1) whether and how readability and visual performance varied with the different combinations of ambient luminance and display luminance and (2) whether and how they influenced the subjective experience (through self-reported valence, annoyance, visual fatigue) and preference. The results indicate a limited, yet negative influence of increased ambient luminance and reduced contrast on visual performance and readability for both displays. Similarly, we found that the self-reported valence decreases and annoyance and visual fatigue increase as the contrast ratio decreases and ambient luminance increases. Overall, the impact is clearer for the matte display than for the glossy display.

Accurate color measurement methods for medical displays.

PubMed

Saha, Anindita; Kelley, Edward F; Badano, Aldo

2010-01-01

The necessity for standard instrumentation and measurements of color that are repeatable and reproducible is the major motivation behind this work. Currently, different instrumentation and methods can yield very different results when measuring the same feature such as color uniformity or color difference. As color increasingly comes into play in medical imaging diagnostics, display color will have to be quantified in order to assess whether the display should be used for imaging purposes. The authors report on the characterization of three novel probes for measuring display color with minimal contamination from screen areas outside the measurement spot or from off-normal emissions. They compare three probe designs: A modified small-spot luminance probe and two conic probe designs based on black frusta. To compare the three color probe designs, spectral and luminance measurements were taken with specialized instrumentation to determine the luminance changes and color separation abilities of the probes. The probes were characterized with a scanning slit method, veiling glare, and a moving laser and LED arrangement. The scanning slit measurement was done using a black slit plate over a white line on an LCD monitor. The luminance was measured in 1 mm increments from the center of the slit to +/- 15 mm above and below the slit at different distances between the probe and the slit. The veiling glare setup consisted of measurements of the luminance of a black spot pattern with a white disk of radius of 100 mm as the black spot increases in 1 mm radius increments. The moving LED and laser method consisted of a red and green light orthogonal to the probe tip for the light to directly shine into the probe. The green light source was moved away from the red source in 1 cm increments to measure color stray-light contamination at different probe distances. The results of the color testing using the LED and laser methods suggest a better performance of one of the frusta probes at shorter distances between the light sources, which translates to less contamination. The tails of the scans indicate the magnitude of the spread in signal due to light from areas outside the intended measurement spot. The measurements indicate a corresponding glare factor for a large spot of 140, 500, and 2000 for probe A, B1, and B2, respectively. The dual-laser setup suggests that color purity can be maintained up to a few tens of millimeters outside the measurement spot. The comparison shows that there are significant differences in the performance of each probe design, and that those differences have an effect on the measured quantity used to quantify display color. Different probe designs show different measurements of the level of light contamination that affects the quantitative color determination.

"Just Doing Stuff"? Place, Memory and Young Men's Educational Disaffection in a Former Coal-Mining Area in England

ERIC Educational Resources Information Center

Bright, N. Geoffrey

2010-01-01

In this article, the author explores some particularly "luminous" paradoxes that have emerged from qualitative material gathered as part of an ethnographic study carried out over the last five years. The research, now a doctoral study, grew initially out of the author's own contradictory experiences of running learning provision in the…

A New Method for Calibrating Perceptual Salience across Dimensions in Infants: The Case of Color vs. Luminance

ERIC Educational Resources Information Center

Kaldy, Zsuzsa; Blaser, Erik A.; Leslie, Alan M.

2006-01-01

We report a new method for calibrating differences in perceptual salience across feature dimensions, in infants. The problem of inter-dimensional salience arises in many areas of infant studies, but a general method for addressing the problem has not previously been described. Our method is based on a preferential looking paradigm, adapted to…

Fabrication of Vertical Organic Light-Emitting Transistor Using ZnO Thin Film

NASA Astrophysics Data System (ADS)

Yamauchi, Hiroshi; Iizuka, Masaaki; Kudo, Kazuhiro

2007-04-01

Organic light-emitting diodes (OLEDs) combined with thin film transistor (TFT) are well suitable elements for low-cost, large-area active matrix displays. On the other hand, zinc oxide (ZnO) is a transparent material and its electrical conductivity is controlled from conductive to insulating by growth conditions. The drain current of ZnO FET is 180 μA. The OLED uses ZnO thin film (Al-doped) for the electron injection layer and is controlled by radio frequency (rf) and direct current (dc) sputtering conditions, such as Al concentration and gas pressure. Al concentration in the ZnO film and deposition rate have strong effects on electron injection. Furthermore, the OLED driven by ZnO FET shows a luminance of 13 cd/m2, a luminance efficiency of 0.7 cd/A, and an on-off ratio of 650.

Bioluminescent signals spatially amplified by wavelength-specific diffusion through the shell of a marine snail.

PubMed

Deheyn, Dimitri D; Wilson, Nerida G

2011-07-22

Some living organisms produce visible light (bioluminescence) for intra- or interspecific visual communication. Here, we describe a remarkable bioluminescent adaptation in the marine snail Hinea brasiliana. This species produces a luminous display in response to mechanical stimulation caused by encounters with other motile organisms. The light is produced from discrete areas on the snail's body beneath the snail's shell, and must thus overcome this structural barrier to be viewed by an external receiver. The diffusion and transmission efficiency of the shell is greater than a commercial diffuser reference material. Most strikingly, the shell, although opaque and pigmented, selectively diffuses the blue-green wavelength of the species bioluminescence. This diffusion generates a luminous display that is enlarged relative to the original light source. This unusual shell thus allows spatially amplified outward transmission of light communication signals from the snail, while allowing the animal to remain safely inside its hard protective shell.

Linear-regression convolutional neural network for fully automated coronary lumen segmentation in intravascular optical coherence tomography

NASA Astrophysics Data System (ADS)

Yong, Yan Ling; Tan, Li Kuo; McLaughlin, Robert A.; Chee, Kok Han; Liew, Yih Miin

2017-12-01

Intravascular optical coherence tomography (OCT) is an optical imaging modality commonly used in the assessment of coronary artery diseases during percutaneous coronary intervention. Manual segmentation to assess luminal stenosis from OCT pullback scans is challenging and time consuming. We propose a linear-regression convolutional neural network to automatically perform vessel lumen segmentation, parameterized in terms of radial distances from the catheter centroid in polar space. Benchmarked against gold-standard manual segmentation, our proposed algorithm achieves average locational accuracy of the vessel wall of 22 microns, and 0.985 and 0.970 in Dice coefficient and Jaccard similarity index, respectively. The average absolute error of luminal area estimation is 1.38%. The processing rate is 40.6 ms per image, suggesting the potential to be incorporated into a clinical workflow and to provide quantitative assessment of vessel lumen in an intraoperative time frame.

The rhythms of predictive coding? Pre-stimulus phase modulates the influence of shape perception on luminance judgments

PubMed Central

Han, Biao; VanRullen, Rufin

2017-01-01

Predictive coding is an influential model emphasizing interactions between feedforward and feedback signals. Here, we investigated the temporal dynamics of these interactions. Two gray disks with different versions of the same stimulus, one enabling predictive feedback (a 3D-shape) and one impeding it (random-lines), were simultaneously presented on the left and right of fixation. Human subjects judged the luminance of the two disks while EEG was recorded. The choice of 3D-shape or random-lines as the brighter disk was used to assess the influence of feedback signals on sensory processing in each trial (i.e., as a measure of post-stimulus predictive coding efficiency). Independently of the spatial response (left/right), we found that this choice fluctuated along with the pre-stimulus phase of two spontaneous oscillations: a ~5 Hz oscillation in contralateral frontal electrodes and a ~16 Hz oscillation in contralateral occipital electrodes. This pattern of results demonstrates that predictive coding is a rhythmic process, and suggests that it could take advantage of faster oscillations in low-level areas and slower oscillations in high-level areas. PMID:28262824

Brazilian Cerrado soil Actinobacteria ecology.

PubMed

Suela Silva, Monique; Naves Sales, Alenir; Teixeira Magalhães-Guedes, Karina; Ribeiro Dias, Disney; Schwan, Rosane Freitas

2013-01-01

A total of 2152 Actinobacteria strains were isolated from native Cerrado (Brazilian Savannah) soils located in Passos, Luminárias, and Arcos municipalities (Minas Gerais State, Brazil). The soils were characterised for chemical and microbiological analysis. The microbial analysis led to the identification of nine genera (Streptomyces, Arthrobacter, Rhodococcus, Amycolatopsis, Microbacterium, Frankia, Leifsonia, Nakamurella, and Kitasatospora) and 92 distinct species in both seasons studied (rainy and dry). The rainy season produced a high microbial population of all the aforementioned genera. The pH values of the soil samples from the Passos, Luminárias, and Arcos regions varied from 4.1 to 5.5. There were no significant differences in the concentrations of phosphorus, magnesium, and organic matter in the soils among the studied areas. Samples from the Arcos area contained large amounts of aluminium in the rainy season and both hydrogen and aluminium in the rainy and dry seasons. The Actinobacteria population seemed to be unaffected by the high levels of aluminium in the soil. Studies are being conducted to produce bioactive compounds from Actinobacteria fermentations on different substrates. The present data suggest that the number and diversity of Actinobacteria spp. in tropical soils represent a vast unexplored resource for the biotechnology of bioactives production.

Brazilian Cerrado Soil Actinobacteria Ecology

PubMed Central

Suela Silva, Monique; Naves Sales, Alenir; Teixeira Magalhães-Guedes, Karina; Ribeiro Dias, Disney; Schwan, Rosane Freitas

2013-01-01

A total of 2152 Actinobacteria strains were isolated from native Cerrado (Brazilian Savannah) soils located in Passos, Luminárias, and Arcos municipalities (Minas Gerais State, Brazil). The soils were characterised for chemical and microbiological analysis. The microbial analysis led to the identification of nine genera (Streptomyces, Arthrobacter, Rhodococcus, Amycolatopsis, Microbacterium, Frankia, Leifsonia, Nakamurella, and Kitasatospora) and 92 distinct species in both seasons studied (rainy and dry). The rainy season produced a high microbial population of all the aforementioned genera. The pH values of the soil samples from the Passos, Luminárias, and Arcos regions varied from 4.1 to 5.5. There were no significant differences in the concentrations of phosphorus, magnesium, and organic matter in the soils among the studied areas. Samples from the Arcos area contained large amounts of aluminium in the rainy season and both hydrogen and aluminium in the rainy and dry seasons. The Actinobacteria population seemed to be unaffected by the high levels of aluminium in the soil. Studies are being conducted to produce bioactive compounds from Actinobacteria fermentations on different substrates. The present data suggest that the number and diversity of Actinobacteria spp. in tropical soils represent a vast unexplored resource for the biotechnology of bioactives production. PMID:23555089

Luminance uniformity compensation for OLED panels based on FPGA

NASA Astrophysics Data System (ADS)

Ou, Peng; Yang, Gang; Jiang, Quan; Yu, Jun-Sheng; Wu, Qi-Peng; Shang, Fu-Hai; Yin, Wei; Wang, Jun; Zhong, Jian; Luo, Kai-Jun

2009-09-01

Aiming at the problem of luminance uniformity for organic lighting-emitting diode (OLED) panels, a new brightness calculating method based on bilinear interpolation is proposed. The irradiance time of each pixel reaching the same luminance is figured out by Matlab. Adopting the 64×32-pixel, single color and passive matrix OLED panel as adjusting luminance uniformity panel, a new circuit compensating scheme based on FPGA is designed. VHDL is used to make each pixel’s irradiance time in one frame period written in program. The irradiance brightness is controlled by changing its irradiance time, and finally, luminance compensation of the panel is realized. The simulation result indicates that the design is reasonable.

Photometric observations of local rocket-atmosphere interactions

NASA Astrophysics Data System (ADS)

Greer, R. G. H.; Murtagh, D. P.; Witt, G.; Stegman, J.

1983-06-01

Photometric measurements from rocket flights which recorded a strong foreign luminance in the altitude region between 90 and 130 km are reported. From one Nike-Orion rocket the luminance appeared on both up-leg and down-leg; from a series of Petrel rockets the luminance was apparent only on the down-leg. The data suggest that the luminance may be distributed mainly in the wake region along the rocket trajectory. The luminance is believed to be due to a local interaction between the rocket and the atmosphere although the precise nature of the interaction is unknown. It was measured at wavelengths ranging from 275 nm to 1.61 microns and may be caused by a combination of reactions.

Calibrated LCD/TFT stimulus presentation for visual psychophysics in fMRI.

PubMed

Strasburger, H; Wüstenberg, T; Jäncke, L

2002-11-15

Standard projection techniques using liquid crystal (LCD) or thin-film transistor (TFT) technology show drastic distortions in luminance and contrast characteristics across the screen and across grey levels. Common luminance measurement and calibration techniques are not applicable in the vicinity of MRI scanners. With the aid of a fibre optic, we measured screen luminances for the full space of screen position and image grey values and on that basis developed a compensation technique that involves both luminance homogenisation and position-dependent gamma correction. By the technique described, images displayed to a subject in functional MRI can be specified with high precision by a matrix of desired luminance values rather than by local grey value.

Pixel-Wise-Inter/Intra-Channel Color and Luminance Uniformity Corrections for Multi-Channel Projection Displays

DTIC Science & Technology

2016-08-11

Journal Article 3. DATES COVERED (From – To) Jan 2015 – Dec 2015 4. TITLE AND SUBTITLE PIXEL-WISE INTER/INTRA-CHANNEL COLOR & LUMINANCE UNIFORMITY...Conference Dayton, Ohio – 28-29 June 2016 14. ABSTRACT Inter- and intra-channel color and luminance are generally non-uniform in multi-channel...projection display systems. Several methods have been proposed to correct for both inter- and intra-channel color and luminance variation in multi-channel

Luminance and chromatic contributions to a hyperacuity task: isolation by contrast polarity and target separation

PubMed Central

Sun, Hao; Cooper, Bonnie; Lee, Barry B.

2012-01-01

Vernier thresholds are known to be elevated when a target pair has opposite contrast polarity. Polarity reversal is used to assess the role of luminance and chromatic pathways in hyperacuity performance. Psychophysical hyperacuity thresholds were measured for pairs of gratings of various combinations of luminance (Lum) and chromatic (Chr) contrast polarities, at different ratios of luminance to chromatic contrast. With two red-green gratings of matched luminance and chromatic polarity (+Lum+Chr), there was an elevation of threshold at isoluminance. When both luminance and chromatic polarity were mismatched (−Lum−Chr), thresholds were substantially elevated under all conditions. With the same luminance contrast polarity and opposite chromatic polarity (+Lum−Chr) thresholds were only elevated close to isoluminance; in the reverse condition (−Lum+Chr), thresholds were elevated as in the −Lum−Chr condition except close to equiluminance. Similar data were obtained for gratings isolating the short-wavelength cone mechanism. Further psychophysical measurements assessed the role of target separation with matched or mismatched contrast polarity; similar results were found for luminance and chromatic gratings. Comparison physiological data were collected from parafoveal ganglion cells of the macaque retina. Positional precision of ganglion cell signals was assessed under conditions related to the psychophysical measurements. On the basis of these combined observations, it is argued that both magnocellular, parvocellular, and koniocellular pathways have access to cortical positional mechanisms associated with vernier acuity. PMID:22306680

Fusion of visible and near-infrared images based on luminance estimation by weighted luminance algorithm

NASA Astrophysics Data System (ADS)

Wang, Zhun; Cheng, Feiyan; Shi, Junsheng; Huang, Xiaoqiao

2018-01-01

In a low-light scene, capturing color images needs to be at a high-gain setting or a long-exposure setting to avoid a visible flash. However, such these setting will lead to color images with serious noise or motion blur. Several methods have been proposed to improve a noise-color image through an invisible near infrared flash image. A novel method is that the luminance component and the chroma component of the improved color image are estimated from different image sources [1]. The luminance component is estimated mainly from the NIR image via a spectral estimation, and the chroma component is estimated from the noise-color image by denoising. However, it is challenging to estimate the luminance component. This novel method to estimate the luminance component needs to generate the learning data pairs, and the processes and algorithm are complex. It is difficult to achieve practical application. In order to reduce the complexity of the luminance estimation, an improved luminance estimation algorithm is presented in this paper, which is to weight the NIR image and the denoised-color image and the weighted coefficients are based on the mean value and standard deviation of both images. Experimental results show that the same fusion effect at aspect of color fidelity and texture quality is achieved, compared the proposed method with the novel method, however, the algorithm is more simple and practical.

Visual ergonomic evaluations on four different designs of LED traffic signs

NASA Astrophysics Data System (ADS)

Chen, Yi-Chun; Huang, Ting-Yuan; Lee, Tsung-Xian; Sun, Ching-Cherng

2017-08-01

To investigate the legibility and visual comfort of LED traffic signs, an ergonomic experiment is performed on four custom-designed LED traffic signs, including three self-luminous ones as LED lightbox, LED backlight and regional LED backlight, and one non-self-luminous sign with external LED lighting. The four signs are hanged side-by-side and evaluated by observers through questionnaires. The signage dimension is one-sixth of the real freeway traffic signs, and the observation distance is 25 m. The luminance of three self-luminous signs is 216 cd/m2. The illuminance of external LED lighting is 400 lux on the traffic sign. The ambient illuminance is 2.8 and 6.0 lux in two rounds. The results show that self-luminous traffic signs provide superior legibility, visual comfort and user preference than the non-self-luminous one. Among the three self-luminous signs, regional LED backlight is most susceptible to the ambient illumination. LED lightbox has significantly better preference score than LED backlight under darker ambient lighting. Only LED lightbox has significantly better visual comfort than external LED lighting in the brighter environment. Based on the four LED traffic signs evaluated in this study, we suggest LED lightbox as the prior choice. Further investigations on the effect of ambient illumination and other designs of self-luminous traffic signs are in progress.

Interaction of color and geometric cues in depth perception: when does "red" mean "near"?

PubMed

Guibal, Christophe R C; Dresp, Birgitta

2004-12-01

Luminance and color are strong and self-sufficient cues to pictorial depth in visual scenes and images. The present study investigates the conditions under which luminance or color either strengthens or overrides geometric depth cues. We investigated how luminance contrast associated with the color red and color contrast interact with relative height in the visual field, partial occlusion, and interposition to determine the probability that a given figure presented in a pair is perceived as "nearer" than the other. Latencies of "near" responses were analyzed to test for effects of attentional selection. Figures in a pair were supported by luminance contrast (Experiment 1) or isoluminant color contrast (Experiment 2) and combined with one of the three geometric cues. The results of Experiment 1 show that the luminance contrast of a color (here red), when it does not interact with other colors, produces the same effects as achromatic luminance contrasts. The probability of "near" increases with the luminance contrast of the color stimulus, the latencies for "near" responses decrease with increasing luminance contrast. Partial occlusion is found to be a strong enough pictorial cue to support a weaker red luminance contrast. Interposition cues lose out against cues of spatial position and partial occlusion. The results of Experiment 2, with isoluminant displays of varying color contrast, reveal that red color contrast on a light background supported by any of the three geometric cues wins over green or white supported by any of the three geometric cues. On a dark background, red color contrast supported by the interposition cue loses out against green or white color contrast supported by partial occlusion. These findings reveal that color is not an independent depth cue, but is strongly influenced by luminance contrast and stimulus geometry. Systematically shorter response latencies for stronger "near" percepts demonstrate that selective visual attention reliably detects the most likely depth cue combination in a given configuration.

O6-methylguanine-DNA methyltransferase as a prognostic and predictive marker for basal-like breast cancer treated with cyclophosphamide-based chemotherapy

PubMed Central

ISONO, SAYURI; FUJISHIMA, MAKOTO; AZUMI, TATSUYA; HASHIMOTO, YUKIHIKO; KOMOIKE, YOSHIFUMI; YUKAWA, MASAO; WATATANI, MASAHIRO

2014-01-01

The O6-methylguanine-DNA methyltransferase (MGMT) protein protects cells from alkylating agents by removing alkyl groups from the O6-position of guanine. However, its effect on DNA damage induced by cyclophosphamide (CPM) is unclear. The present study investigated whether MGMT expression was correlated with prognosis in patients with breast cancer that was managed according to a common therapeutic protocol or treated with CPM-based chemotherapy. The intrinsic subtypes and MGMT protein expression levels were assessed in 635 consecutive patients with breast cancer using immunohistochemistry. In total, 425 (67%) luminal A, 95 (15%) luminal B, 47 (7%) human epidermal growth factor receptor-2+/estrogen receptor− (HER2+/ER−) and 48 (8%) basal-like subtypes were identified. Of these, MGMT positivity was identified in 398 (63%) of 635 breast cancers; 68% of luminal A, 67% of luminal B, 30% of HER2+/ER− and 46% of basal-like subtypes were positive. The overall survival (OS) and disease-free survival (DFS) rates did not significantly differ according to the MGMT status among patients with luminal A, luminal B or HER2+/ER− subtypes, and patients with MGMT-negative basal-like cancers tended to have a longer DFS, but not a significantly longer OS time. CPM-containing chemotherapy was administered to 26%, 40%, 47% and 31% of patients with luminal A, luminal B, HER2+/ER− and basal-like tumors, respectively. Although the MGMT status and clinical outcomes of patients with the luminal A, luminal B or HER2+/ER− subtypes treated with CPM were not significantly correlated, the patients with MGMT-negative basal-like tumors who received CPM exhibited significantly improved DFS and OS compared with the CPM-treated patients with MGMT-positive tumors. MGMT may be a useful prognostic and predictive marker for CPM-containing chemotherapy in basal-like breast cancer. PMID:24932232

O6-methylguanine-DNA methyltransferase as a prognostic and predictive marker for basal-like breast cancer treated with cyclophosphamide-based chemotherapy.

PubMed

Isono, Sayuri; Fujishima, Makoto; Azumi, Tatsuya; Hashimoto, Yukihiko; Komoike, Yoshifumi; Yukawa, Masao; Watatani, Masahiro

2014-06-01

The O 6 -methylguanine-DNA methyltransferase (MGMT) protein protects cells from alkylating agents by removing alkyl groups from the O 6 -position of guanine. However, its effect on DNA damage induced by cyclophosphamide (CPM) is unclear. The present study investigated whether MGMT expression was correlated with prognosis in patients with breast cancer that was managed according to a common therapeutic protocol or treated with CPM-based chemotherapy. The intrinsic subtypes and MGMT protein expression levels were assessed in 635 consecutive patients with breast cancer using immunohistochemistry. In total, 425 (67%) luminal A, 95 (15%) luminal B, 47 (7%) human epidermal growth factor receptor-2 + /estrogen receptor - (HER2 + /ER - ) and 48 (8%) basal-like subtypes were identified. Of these, MGMT positivity was identified in 398 (63%) of 635 breast cancers; 68% of luminal A, 67% of luminal B, 30% of HER2 + /ER - and 46% of basal-like subtypes were positive. The overall survival (OS) and disease-free survival (DFS) rates did not significantly differ according to the MGMT status among patients with luminal A, luminal B or HER2 + /ER - subtypes, and patients with MGMT-negative basal-like cancers tended to have a longer DFS, but not a significantly longer OS time. CPM-containing chemotherapy was administered to 26%, 40%, 47% and 31% of patients with luminal A, luminal B, HER2 + /ER - and basal-like tumors, respectively. Although the MGMT status and clinical outcomes of patients with the luminal A, luminal B or HER2 + /ER - subtypes treated with CPM were not significantly correlated, the patients with MGMT-negative basal-like tumors who received CPM exhibited significantly improved DFS and OS compared with the CPM-treated patients with MGMT-positive tumors. MGMT may be a useful prognostic and predictive marker for CPM-containing chemotherapy in basal-like breast cancer.

Optimal Solution Volume for Luminal Preservation: A Preclinical Study in Porcine Intestinal Preservation.

PubMed

Oltean, M; Papurica, M; Jiga, L; Hoinoiu, B; Glameanu, C; Bresler, A; Patrut, G; Grigorie, R; Ionac, M; Hellström, M

2016-03-01

Rodent studies suggest that luminal solutions alleviate the mucosal injury and prolong intestinal preservation but concerns exist that excessive volumes of luminal fluid may promote tissue edema. Differences in size, structure, and metabolism between rats and humans require studies in large animals before clinical use. Intestinal procurement was performed in 7 pigs. After perfusion with histidine-tryptophan-ketoglutarate (HTK), 40-cm-long segments were cut and filled with 13.5% polyethylene glycol (PEG) 3350 solution as follows: V0 (controls, none), V1 (0.5 mL/cm), V2 (1 mL/cm), V3 (1.5 mL/cm), and V4 (2 mL/cm). Tissue and luminal solutions were sampled after 8, 14, and 24 hours of cold storage (CS). Preservation injury (Chiu score), the apical membrane (ZO-1, brush-border maltase activity), and the electrolyte content in the luminal solution were studied. In control intestines, 8-hour CS in HTK solution resulted in minimal mucosal changes (grade 1) that progressed to significant subepithelial edema (grade 3) by 24 hours. During this time, a gradual loss in ZO-1 was recorded, whereas maltase activity remained unaltered. Moreover, variable degrees of submucosal edema were observed. Luminal introduction of high volumes (2 mL/mL) of PEG solution accelerated the development of the subepithelial edema and submucosal edema, leading to worse histology. However, ZO-1 was preserved better over time than in control intestines (no luminal solution). Maltase activity was reduced in intestines receiving luminal preservation. Luminal sodium content decreased in time and did not differ between groups. This PEG solution protects the apical membrane and the tight-junction proteins but may favor water absorption and tissue (submucosal) edema, and luminal volumes >2 mL/cm may result in worse intestinal morphology. Copyright © 2016 Elsevier Inc. All rights reserved.

Internal noise sources limiting contrast sensitivity.

PubMed

Silvestre, Daphné; Arleo, Angelo; Allard, Rémy

2018-02-07

Contrast sensitivity varies substantially as a function of spatial frequency and luminance intensity. The variation as a function of luminance intensity is well known and characterized by three laws that can be attributed to the impact of three internal noise sources: early spontaneous neural activity limiting contrast sensitivity at low luminance intensities (i.e. early noise responsible for the linear law), probabilistic photon absorption at intermediate luminance intensities (i.e. photon noise responsible for de Vries-Rose law) and late spontaneous neural activity at high luminance intensities (i.e. late noise responsible for Weber's law). The aim of this study was to characterize how the impact of these three internal noise sources vary with spatial frequency and determine which one is limiting contrast sensitivity as a function of luminance intensity and spatial frequency. To estimate the impact of the different internal noise sources, the current study used an external noise paradigm to factorize contrast sensitivity into equivalent input noise and calculation efficiency over a wide range of luminance intensities and spatial frequencies. The impact of early and late noise was found to drop linearly with spatial frequency, whereas the impact of photon noise rose with spatial frequency due to ocular factors.

What's in a ray set: moving towards a unified ray set format

NASA Astrophysics Data System (ADS)

Muschaweck, Julius

2011-10-01

For the purpose of optical simulation, a plethora of formats exist to describe the properties of a light source. Except for the EULUMDAT and IES formats which describe sources in terms of aperture area and far field intensity, all these formats are vendor specific, and no generally accepted standard exists. Most illumination simulation software vendors use their own format for ray sets, which describe sources in terms of many rays. Some of them keep their format definition proprietary. Thus, software packages typically can read or write only their own specific format, although the actual data content is not so different. Typically, they describe origin and direction of each ray in 3D vectors, and use one more single number for magnitude, where magnitude may denote radiant flux, luminous flux (equivalently tristimulus Y), or tristimulus X and Z. Sometimes each ray also carries its wavelength, while other formats allow to specify an overall spectrum for the whole source. In addition, in at least one format, polarization properties are also included for each ray. This situation makes it inefficient and potentially error prone for light source manufacturers to provide ray data sets for their sources in many different formats. Furthermore, near field goniometer vendors again use their proprietary formats to store the source description in terms of luminance data, and offer their proprietary software to generate ray sets from this data base. Again, the plethora of ray sets make the ray set production inefficient and potentially error prone. In this paper, we propose to describe ray data sets in terms of phase space, as a step towards a standardized ray set format. It is well known that luminance and radiance can be defined as flux density in phase space: luminance is flux divided by etendue. Therefore, single rays can be thought of as center points of phase space cells, where each cell possesses its volume (i.e. etendue), its flux, and therefore its luminance. In addition, each phase space cell possesses its spectrum, and its polarization properties. We show how this approach leads to a unification of the EULUMDAT/IES, ray set and near field goniometer formats, making possible the generation of arbitrarily many additional rays by luminance interpolation. We also show how the EULUMDAT/IES and individual ray set formats can be derived from the proposed general format, making software using a possible standard format downward compatible.

PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers

PubMed Central

2012-01-01

Background Many methodologies have been used in research to identify the “intrinsic” subtypes of breast cancer commonly known as Luminal A, Luminal B, HER2-Enriched (HER2-E) and Basal-like. The PAM50 gene set is often used for gene expression-based subtyping; however, surrogate subtyping using panels of immunohistochemical (IHC) markers are still widely used clinically. Discrepancies between these methods may lead to different treatment decisions. Methods We used the PAM50 RT-qPCR assay to expression profile 814 tumors from the GEICAM/9906 phase III clinical trial that enrolled women with locally advanced primary invasive breast cancer. All samples were scored at a single site by IHC for estrogen receptor (ER), progesterone receptor (PR), and Her2/neu (HER2) protein expression. Equivocal HER2 cases were confirmed by chromogenic in situ hybridization (CISH). Single gene scores by IHC/CISH were compared with RT-qPCR continuous gene expression values and “intrinsic” subtype assignment by the PAM50. High, medium, and low expression for ESR1, PGR, ERBB2, and proliferation were selected using quartile cut-points from the continuous RT-qPCR data across the PAM50 subtype assignments. Results ESR1, PGR, and ERBB2 gene expression had high agreement with established binary IHC cut-points (area under the curve (AUC) ≥ 0.9). Estrogen receptor positivity by IHC was strongly associated with Luminal (A and B) subtypes (92%), but only 75% of ER negative tumors were classified into the HER2-E and Basal-like subtypes. Luminal A tumors more frequently expressed PR than Luminal B (94% vs 74%) and Luminal A tumors were less likely to have high proliferation (11% vs 77%). Seventy-seven percent (30/39) of ER-/HER2+ tumors by IHC were classified as the HER2-E subtype. Triple negative tumors were mainly comprised of Basal-like (57%) and HER2-E (30%) subtypes. Single gene scoring for ESR1, PGR, and ERBB2 was more prognostic than the corresponding IHC markers as shown in a multivariate analysis. Conclusions The standard immunohistochemical panel for breast cancer (ER, PR, and HER2) does not adequately identify the PAM50 gene expression subtypes. Although there is high agreement between biomarker scoring by protein immunohistochemistry and gene expression, the gene expression determinations for ESR1 and ERBB2 status was more prognostic. PMID:23035882

Advancing Our Understanding of the Etiologies and Mutational Landscapes of Basal-Like, Luminal A, and Luminal B Breast Cancers

DTIC Science & Technology

2014-10-01

Under Dr. Li’s supervision, the study coordinator, Ms. Taylor, will oversee the training of the study’s field and random digit dialing (RDD...so that luminal A and luminal B cases can be distinguished from each other. All triple-negative cases will be evaluated for EGFR and cytokeratin 5/6...mutations and small indels will be validated by PCR amplification of the identified exons in tumor and matched normal DNA followed by PCR cleanup using

Advancing Our Understanding of the Etiologies and Mutational Landscapes of Basal-Like, Luminal A, and Luminal B Breast Cancers

DTIC Science & Technology

2013-10-01

will oversee the training of the study’s field and random digit dialing (RDD) interviewers. To support this and on-going training, Ms. Taylor will...luminal A and luminal B cases can be distinguished from each other. All Page 9 triple-negative cases will be evaluated for EGFR and cytokeratin 5/6...point mutations and small indels will be validated by PCR amplification of the identified exons in tumor and matched normal DNA followed by PCR

Method and apparatus for an optical function generator for seamless tiled displays

NASA Technical Reports Server (NTRS)

Johnson, Michael (Inventor); Chen, Chung-Jen (Inventor)

2004-01-01

Producing seamless tiled images from multiple displays includes measuring a luminance profile of each of the displays, computing a desired luminance profile for each of the displays, and determining a spatial gradient profile of each of the displays based on the measured luminance profile and the computed desired luminance profile. The determined spatial gradient profile is applied to a spatial filter to be inserted into each of the displays to produce the seamless tiled display image.

Advancing Our Understanding of the Etiologies and Mutational Landscapes of Basal Like, Luminal A, and Luminal B Breast Cancers

DTIC Science & Technology

2016-10-01

like, luminal A, and luminal B tumors. Our original goal was to recruit about 2,700 women in Western Washington who have been diagnosed with breast...cancer to compare to 900 women who have never been diagnosed with breast cancer, but control ascertainment has been unacceptably low, so on 8/25/15 we...group of 900 women without breast cancer. Control ascertainment did not go as planned due to significant changes in telephone equipment and practices

The Effect of Light Level and Small Pupils on Presbyopic Reading Performance.

PubMed

Xu, Renfeng; Gil, Daniel; Dibas, Mohammed; Hare, William; Bradley, Arthur

2016-10-01

To examine the impact of small pupils and light levels on reading performance of distance-corrected presbyopes. To determine whether small pupils would enable presbyopes to read at near even at low light levels. To establish the lower range of text luminances, we quantified the space-averaged luminance of text in nine different artificially lit interior environments, and examined the impact of the text characters on space-averaged luminance of electronic and printed displays. Distance and near reading speeds of 20 presbyopes (ages 40-60 years) were measured while viewing through artificial pupils (diameters 1-4.5 mm), natural pupils, or with a multifocal contact lens. Space-averaged text luminance levels varied from 0.14 to 140 cd/m2 (including the range of measured environmental text luminances). Adding black text to a white computer display or paper reduces luminance by approximately 15% to 31%, and the lowest encountered environmental text luminance was approximately 2 to 3 cd/m2. For both distance and near reading performance, the 2- to 3-mm small pupil yielded the best overall reading acuity for space-averaged text light levels ≥ 2 cd/m2. The 2- to 3-mm artificial pupils and the multifocal contact lenses both enabled maximum or near-maximum reading speeds for 0.5 logMAR characters at distance and near, but with natural pupils, reading speeds were significantly reduced at near. Although photon noise at low luminance reduces the visual benefits of small pupils, the benefits of 2- to 3-mm artificial pupils are sufficient to enable >80% of distance-corrected presbyopes to read proficiently at near, even at the lowest text luminances found in interior environments.

Shapes of Nonbuoyant Round Luminous Hydrocarbon/Air Laminar Jet Diffusion Flames

NASA Technical Reports Server (NTRS)

Lin, K.-C.; Faeth, G. M.; Sunderland, P. B.; Urban, D. L.; Yuan, Z.-G.

1999-01-01

The shapes (luminous flame boundaries) of round luminous nonbuoyant soot-containing hydrocarbon/air laminar jet diffusion flames at microgravity were found from color video images obtained on orbit in the Space Shuttle Columbia. Test conditions included ethylene- and propane-fueled flames burning in still air at an ambient temperature of 300 K, ambient pressures of 35-130 kPa, initial jet diameters of 1.6 and 2.7 mm, and jet exit Reynolds numbers of 45-170. Present test times were 100-200 s and yielded steady axisymmetric flames that were close to the laminar smoke point (including flames both emitting and not emitting soot) with luminous flame lengths of 15-63 mm. The present soot-containing flames had larger luminous flame lengths than earlier ground-based observations having similar burner configurations: 40% larger than the luminous flame lengths of soot-containing low gravity flames observed using an aircraft (KC-135) facility due to reduced effects of accelerative disturbances and unsteadiness; roughly twice as large as the luminous flame lengths of soot-containing normal gravity flames due to the absence of effects of buoyant mixing and roughly twice as large as the luminous flame lengths of soot-free low gravity flames observed using drop tower facilities due to the presence of soot luminosity and possible reduced effects of unsteadiness. Simplified expressions to estimate the luminous flame boundaries of round nonbuoyant laminar jet diffusion flames were obtained from the classical analysis of Spalding (1979); this approach provided Successful Correlations of flame shapes for both soot-free and soot-containing flames, except when the soot-containing flames were in the opened-tip configuration that is reached at fuel flow rates near and greater than the laminar smoke point fuel flow rate.

Shapes of Nonbuoyant Round Luminous Hydrocarbon/Air Laminar Jet Diffusion Flames. Appendix H

NASA Technical Reports Server (NTRS)

Lin, K.-C.; Faeth, G. M.; Sunderland, P. B.; Urban, D. L.; Yuan, Z.-G.; Ross, Howard B. (Technical Monitor)

2000-01-01

The shapes (luminous flame boundaries) of round luminous nonbuoyant soot-containing hydrocarbon/air laminar jet diffusion flames at microgravity were found from color video images obtained on orbit in the Space Shuttle Columbia. Test conditions included ethylene- and propane-fueled flames burning in still air at an ambient temperature of 300 K ambient pressures of 35-130 kPa, initial jet diameters of 1.6 and 2.7 mm, and jet exit Reynolds numbers of 45-170. Present test times were 100-200 s and yielded steady axisymmetric flames that were close to the laminar smoke point (including flames both emitting and not emitting soot) with luminous flame lengths of 15-63 mm. The present soot-containing flames had larger luminous flame lengths than earlier ground-based observations having similar burner configurations: 40% larger than the luminous flame lengths of soot-containing low gravity flames observed using an aircraft (KC-135) facility due to reduced effects of accelerative disturbances and unsteadiness; roughly twice as large as the luminous flame lengths of soot-containing normal gravity flames due to the absence of effects of buoyant mixing and roughly twice as large as the luminous flame lengths of soot-free low gravity flames observed using drop tower facilities due to the presence of soot luminosity and possible reduced effects of unsteadiness, Simplified expressions to estimate the luminous flame boundaries of round nonbuoyant laminar jet diffusion flames were obtained from the classical analysis of Spalding; this approach provided successful correlations of flame shapes for both soot-free and soot-containing flames, except when the soot-containing flames were in the opened-tip configuration that is reached at fuel flow rates near and greater than the laminar smoke point fuel flow rate.

The impact of luminance on tonic and phasic pupillary responses to sustained cognitive load.

PubMed

Peysakhovich, Vsevolod; Vachon, François; Dehais, Frédéric

2017-02-01

Pupillary reactions independent of light conditions have been linked to cognition for a long time. However, the light conditions can impact the cognitive pupillary reaction. Previous studies underlined the impact of luminance on pupillary reaction, but it is still unclear how luminance modulates the sustained and transient components of pupillary reaction - tonic pupil diameter and phasic pupil response. In the present study, we investigated the impact of the luminance on these two components under sustained cognitive load. Fourteen participants performed a novel working memory task combining mathematical computations with a classic n-back task. We studied both tonic pupil diameter and phasic pupil response under low (1-back) and high (2-back) working memory load and two luminance levels (gray and white). We found that the impact of working memory load on the tonic pupil diameter was modulated by the level of luminance, the increase in tonic pupil diameter with the load being larger under lower luminance. In contrast, the smaller phasic pupil response found under high load remained unaffected by luminance. These results showed that luminance impacts the cognitive pupillary reaction - tonic pupil diameter (phasic pupil response) being modulated under sustained (respectively, transient) cognitive load. These findings also support the relationship between the locus-coeruleus system, presumably functioning in two firing modes - tonic and phasic - and the pupil diameter. We suggest that the tonic pupil diameter tracks the tonic activity of the locus-coeruleus while phasic pupil response reflects its phasic activity. Besides, the designed novel cognitive paradigm allows the simultaneous manipulation of sustained and transient components of the cognitive load and is useful for dissociating the effects on the tonic pupil diameter and phasic pupil response. Copyright © 2016 Elsevier B.V. All rights reserved.

Chicks use changes in luminance and chromatic contrast as indicators of the sign of defocus

PubMed Central

Rucker, Frances J.; Wallman, Josh

2012-01-01

As the eye changes focus, the resulting changes in cone contrast are associated with changes in color and luminance. Color fluctuations should simulate the eye being hyperopic and make the eye grow in the myopic direction, while luminance fluctuations should simulate myopia and make the eye grow in the hyperopic direction. Chicks without lenses were exposed daily (9 a.m. to 5 p.m.) for three days on two consecutive weeks to 2 Hz sinusoidally modulated illumination (mean illuminance of 680 lux) to one of the following: in-phase modulated luminance flicker (LUM), counterphase-modulated red/green (R/G Color) or blue/yellow flicker (B/Y Color), combined color and luminance flicker (Color + LUM), reduced amplitude luminance flicker (Low LUM), or no flicker. After the three-day exposure to flicker, chicks were kept in a brooder under normal diurnal lighting for four days. Changes in the ocular components were measured with ultrasound and with a Hartinger Coincidence Refractometer (aus Jena, Jena, East Germany. After the first three-day exposure, luminance flicker produced more hyperopic refractions (LUM: 2.27 D) than did color flicker (R/G Color: 0.09 D; B/Y Color: −0.25 D). Changes in refraction were mainly due to changes in eye length, with color flicker producing much greater changes in eye length than luminance flicker (R/G Color: 102 μm; B/Y Color: 98 μm; LUM: 66 μm). Our results support the hypothesis that the eye can differentiate between hyperopic and myopic defocus on the basis of the effects of change in luminance or color contrast. PMID:22715194

Ancestry as a potential modifier of gene expression in breast tumors from Colombian women

PubMed Central

Serrano-Gómez, Silvia J.; Sanabria-Salas, María Carolina; Garay, Jone; Baddoo, Melody C.; Hernández-Suarez, Gustavo; Mejía, Juan Carlos; García, Oscar; Miele, Lucio

2017-01-01

Background Hispanic/Latino populations are a genetically admixed and heterogeneous group, with variable fractions of European, Indigenous American and African ancestries. The molecular profile of breast cancer has been widely described in non-Hispanic Whites but equivalent knowledge is lacking in Hispanic/Latinas. We have previously reported that the most prevalent breast cancer intrinsic subtype in Colombian women was Luminal B as defined by St. Gallen 2013 criteria. In this study we explored ancestry-associated differences in molecular profiles of Luminal B tumors among these highly admixed women. Methods We performed whole-transcriptome RNA-seq analysis in 42 Luminal tumors (21 Luminal A and 21 Luminal B) from Colombian women. Genetic ancestry was estimated from a panel of 80 ancestry-informative markers (AIM). We categorized patients according to Luminal subtype and to the proportion of European and Indigenous American ancestry and performed differential expression analysis comparing Luminal B against Luminal A tumors according to the assigned ancestry groups. Results We found 5 genes potentially modulated by genetic ancestry: ERBB2 (log2FC = 2.367, padj<0.01), GRB7 (log2FC = 2.327, padj<0.01), GSDMB (log2FC = 1.723, padj<0.01, MIEN1 (log2FC = 2.195, padj<0.01 and ONECUT2 (log2FC = 2.204, padj<0.01). In the replication set we found a statistical significant association between ERBB2 expression with Indigenous American ancestry (p = 0.02, B = 3.11). This association was not biased by the distribution of HER2+ tumors among the groups analyzed. Conclusions Our results suggest that genetic ancestry in Hispanic/Latina women might modify ERBB2 gene expression in Luminal tumors. Further analyses are needed to confirm these findings and explore their prognostic value. PMID:28832682

Prognostics Health Management Model for LED Package Failure Under Contaminated Environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lall, Pradeep; Zhang, Hao; Davis, J Lynn

2015-06-06

The reliability consideration of LED products includes both luminous flux drop and color shift. Previous research either talks about luminous maintenance or color shift, because luminous flux degradation usually takes very long time to observe. In this paper, the impact of a VOC (volatile organic compound) contaminated luminous flux and color stability are examined. As a result, both luminous degradation and color shift had been recorded in a short time. Test samples are white, phosphor-converted, high-power LED packages. Absolute radiant flux is measured with integrating sphere system to calculate the luminous flux. Luminous flux degradation and color shift distance weremore » plotted versus aging time to show the degradation pattern. A prognostic health management (PHM) method based on the state variables and state estimator have been proposed in this paper. In this PHM framework, unscented kalman filter (UKF) was deployed as the carrier of all states. During the estimation process, third order dynamic transfer function was used to implement the PHM framework. Both of the luminous flux and color shift distance have been used as the state variable with the same PHM framework to exam the robustness of the method. Predicted remaining useful life is calculated at every measurement point to compare with the tested remaining useful life. The result shows that state estimator can be used as the method for the PHM of LED degradation with respect to both luminous flux and color shift distance. The prediction of remaining useful life of LED package, made by the states estimator and data driven approach, falls in the acceptable error-bounds (20%) after a short training of the estimator.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lall, Pradeep; Zang, Hao; Davis, J Lynn

The reliability of LED products may be affected by both luminous flux drop and color shift. Previous research on the topic focuses on either luminous maintenance or color shift. However, luminous flux degradation usually takes very long time to observe in LEDs under normal operating conditions. In this paper, the impact of a VOC (volatile organic compound) contaminated luminous flux and color stability are examined. As a result, both luminous degradation and color shift had been recorded in a short time. Test samples are white, phosphorconverted, high-power LED packages. Absolute radiant flux is measured with integrating sphere system to calculatemore » the luminous flux. Luminous flux degradation and color shift distance were plotted versus aging time to show the degradation pattern. A prognostic health management (PHM) method based on the state variables and state estimator have been proposed in this paper. In this PHM framework, unscented kalman filter (UKF) was deployed as the carrier of all states. During the estimation process, third order dynamic transfer function was used to implement the PHM framework. Both of the luminous flux and color shift distance have been used as the state variable with the same PHM framework to exam the robustness of the method. Predicted remaining useful life is calculated at every measurement point to compare with the tested remaining useful life. The result shows that state estimator can be used as the method for the PHM of LED degradation with respect to both luminous flux and color shift distance. The prediction of remaining useful life of LED package, made by the states estimator and data driven approach, falls in the acceptable errorbounds (20%) after a short training of the estimator.« less

High-luminance LEDs replace incandescent lamps in new applications

NASA Astrophysics Data System (ADS)

Evans, David L.

1997-04-01

The advent of high luminance AlInGaP and InGaN LED technologies has prompted the use of LED devices in new applications formally illuminated by incandescent lamps. The luminous efficiencies of these new LED technologies equals or exceeds that attainable with incandescent sources, with reliability factors that far exceed those of incandescent sources. The need for a highly efficient, dependable, and cost effective replacement for incandescent lamps is being fulfilled with high luminance LED lamps. This paper briefly described some of the new applications incorporating high luminance LED lamps, traffic signals and roadway signs for traffic management, automotive exterior lighting, active matrix and full color displays for commercial advertising, and commercial aircraft panel lighting and military aircraft NVG compatible lighting.

Luminous Enteric Bacteria of Marine Fishes: a Study of Their Distribution, Densities, and Dispersion †

PubMed Central

Ruby, E. G.; Morin, J. G.

1979-01-01

Three taxa of luminous bacteria (Photobacterium fischeri, P. phosphoreum, and Beneckea spp.) were found in the enteric microbial populations of 22 species of surface- and midwater-dwelling fishes. These bacteria often occurred in concentrations ranging between 105 and 107 colony-forming units per ml of enteric contents. By using a genetically marked strain, it was determined that luminous cells entering the fish during ingestion of seawater or contaminated particles traversed the alimentary tract and survived the digestive processes. After excretion, luminous bacteria proliferated extensively on the fecal material and became distributed into the surrounding seawater. Thus, this enteric habitat may serve as an enrichment of viable cells entering the planktonic luminous population. PMID:16345429

A new spatial integration method for luminous flux determination of light-emitting diodes

NASA Astrophysics Data System (ADS)

Zhou, Xiaoli; Zhu, Shaolong; Shen, Haiping; Liu, Muqing

2010-10-01

Spatial integrated measurement using an integrating sphere is usually used for the luminous flux determination of light sources. Devices using an integrating sphere are bulky for use on a production assembly line. This paper proposes an alternative spatial integration method for accurately measuring the total luminous flux of light-emitting diodes (LEDs) having no backward emission. A compound parabolic concentrator is introduced to collect the light from an LED in conjunction with a detector which in turn measures the luminous flux. The study reported here combines both modeling and experiment to show the applicability of this novel method. The uncertainty in the measurements is then evaluated for the total luminous flux measurement from an LED.

What causes IOR? Attention or perception? - manipulating cue and target luminance in either blocked or mixed condition.

PubMed

Zhao, Yuanyuan; Heinke, Dietmar

2014-12-01

Inhibition of return (IOR) refers to the performance disadvantage when detecting a target presented at a previously cued location. The current paper contributes to the long-standing debate whether IOR is caused by attentional processing or perceptual processing. We present a series of four experiments which varied the cue luminance in mixed and blocked conditions. We hypothesised that if inhibition was initialized by an attentional process the size of IOR should not vary in the blocked condition as participants should be able to adapt to the level of cue luminance. However, if a perceptual process triggers inhibition both experimental manipulations should lead to varying levels of IOR. Indeed, we found evidence for the latter hypothesis. In addition, we also varied the target luminance in blocked and mixed condition. Both manipulations, cue luminance and target luminance, affected IOR in an additive fashion suggesting that the two stimuli affect human behaviour on different processing stages. Copyright © 2014 Elsevier Ltd. All rights reserved.

Luminance and chromatic contributions to a hyperacuity task: isolation by contrast polarity and target separation.

PubMed

Sun, Hao; Cooper, Bonnie; Lee, Barry B

2012-03-01

Vernier thresholds are known to be elevated when a target pair has opposite contrast polarity. Polarity reversal is used to assess the role of luminance and chromatic pathways in hyperacuity performance. Psychophysical hyperacuity thresholds were measured for pairs of gratings of various combinations of luminance (Lum) and chromatic (Chr) contrast polarities, at different ratios of luminance to chromatic contrast. With two red-green gratings of matched luminance and chromatic polarity (+Lum+Chr), there was an elevation of threshold at isoluminance. When both luminance and chromatic polarity were mismatched (-Lum-Chr), thresholds were substantially elevated under all conditions. With the same luminance contrast polarity and opposite chromatic polarity (+Lum-Chr) thresholds were only elevated close to isoluminance; in the reverse condition (-Lum+Chr), thresholds were elevated as in the -Lum-Chr condition except close to equiluminance. Similar data were obtained for gratings isolating the short-wavelength cone mechanism. Further psychophysical measurements assessed the role of target separation with matched or mismatched contrast polarity; similar results were found for luminance and chromatic gratings. Comparison physiological data were collected from parafoveal ganglion cells of the macaque retina. Positional precision of ganglion cell signals was assessed under conditions related to the psychophysical measurements. On the basis of these combined observations, it is argued that both magnocellular, parvocellular, and koniocellular pathways have access to cortical positional mechanisms associated with vernier acuity. Copyright © 2012 Elsevier Ltd. All rights reserved.

Signs of depth-luminance covariance in 3-D cluttered scenes.

PubMed

Scaccia, Milena; Langer, Michael S

2018-03-01

In three-dimensional (3-D) cluttered scenes such as foliage, deeper surfaces often are more shadowed and hence darker, and so depth and luminance often have negative covariance. We examined whether the sign of depth-luminance covariance plays a role in depth perception in 3-D clutter. We compared scenes rendered with negative and positive depth-luminance covariance where positive covariance means that deeper surfaces are brighter and negative covariance means deeper surfaces are darker. For each scene, the sign of the depth-luminance covariance was given by occlusion cues. We tested whether subjects could use this sign information to judge the depth order of two target surfaces embedded in 3-D clutter. The clutter consisted of distractor surfaces that were randomly distributed in a 3-D volume. We tested three independent variables: the sign of the depth-luminance covariance, the colors of the targets and distractors, and the background luminance. An analysis of variance showed two main effects: Subjects performed better when the deeper surfaces were darker and when the color of the target surfaces was the same as the color of the distractors. There was also a strong interaction: Subjects performed better under a negative depth-luminance covariance condition when targets and distractors had different colors than when they had the same color. Our results are consistent with a "dark means deep" rule, but the use of this rule depends on the similarity between the color of the targets and color of the 3-D clutter.

Optical coherence tomography compared with intravascular ultrasound and with angiography to guide coronary stent implantation (ILUMIEN III: OPTIMIZE PCI): a randomised controlled trial.

PubMed

Ali, Ziad A; Maehara, Akiko; Généreux, Philippe; Shlofmitz, Richard A; Fabbiocchi, Franco; Nazif, Tamim M; Guagliumi, Giulio; Meraj, Perwaiz M; Alfonso, Fernando; Samady, Habib; Akasaka, Takashi; Carlson, Eric B; Leesar, Massoud A; Matsumura, Mitsuaki; Ozan, Melek Ozgu; Mintz, Gary S; Ben-Yehuda, Ori; Stone, Gregg W

2016-11-26

Percutaneous coronary intervention (PCI) is most commonly guided by angiography alone. Intravascular ultrasound (IVUS) guidance has been shown to reduce major adverse cardiovascular events (MACE) after PCI, principally by resulting in a larger postprocedure lumen than with angiographic guidance. Optical coherence tomography (OCT) provides higher resolution imaging than does IVUS, although findings from some studies suggest that it might lead to smaller luminal diameters after stent implantation. We sought to establish whether or not a novel OCT-based stent sizing strategy would result in a minimum stent area similar to or better than that achieved with IVUS guidance and better than that achieved with angiography guidance alone. In this randomised controlled trial, we recruited patients aged 18 years or older undergoing PCI from 29 hospitals in eight countries. Eligible patients had one or more target lesions located in a native coronary artery with a visually estimated reference vessel diameter of 2·25-3·50 mm and a length of less than 40 mm. We excluded patients with left main or ostial right coronary artery stenoses, bypass graft stenoses, chronic total occlusions, planned two-stent bifurcations, and in-stent restenosis. Participants were randomly assigned (1:1:1; with use of an interactive web-based system in block sizes of three, stratified by site) to OCT guidance, IVUS guidance, or angiography-guided stent implantation. We did OCT-guided PCI using a specific protocol to establish stent length, diameter, and expansion according to reference segment external elastic lamina measurements. All patients underwent final OCT imaging (operators in the IVUS and angiography groups were masked to the OCT images). The primary efficacy endpoint was post-PCI minimum stent area, measured by OCT at a masked independent core laboratory at completion of enrolment, in all randomly allocated participants who had primary outcome data. The primary safety endpoint was procedural MACE. We tested non-inferiority of OCT guidance to IVUS guidance (with a non-inferiority margin of 1·0 mm 2 ), superiority of OCT guidance to angiography guidance, and superiority of OCT guidance to IVUS guidance, in a hierarchical manner. This trial is registered with ClinicalTrials.gov, number NCT02471586. Between May 13, 2015, and April 5, 2016, we randomly allocated 450 patients (158 [35%] to OCT, 146 [32%] to IVUS, and 146 [32%] to angiography), with 415 final OCT acquisitions analysed for the primary endpoint (140 [34%] in the OCT group, 135 [33%] in the IVUS group, and 140 [34%] in the angiography group). The final median minimum stent area was 5·79 mm 2 (IQR 4·54-7·34) with OCT guidance, 5·89 mm 2 (4·67-7·80) with IVUS guidance, and 5·49 mm 2 (4·39-6·59) with angiography guidance. OCT guidance was non-inferior to IVUS guidance (one-sided 97·5% lower CI -0·70 mm 2 ; p=0·001), but not superior (p=0·42). OCT guidance was also not superior to angiography guidance (p=0·12). We noted procedural MACE in four (3%) of 158 patients in the OCT group, one (1%) of 146 in the IVUS group, and one (1%) of 146 in the angiography group (OCT vs IVUS p=0·37; OCT vs angiography p=0·37). OCT-guided PCI using a specific reference segment external elastic lamina-based stent optimisation strategy was safe and resulted in similar minimum stent area to that of IVUS-guided PCI. These data warrant a large-scale randomised trial to establish whether or not OCT guidance results in superior clinical outcomes to angiography guidance. St Jude Medical. Copyright © 2016 Elsevier Ltd. All rights reserved.

Evaluating the effectiveness of treatment of corneal ulcers via computer-based automatic image analysis

NASA Astrophysics Data System (ADS)

Otoum, Nesreen A.; Edirisinghe, Eran A.; Dua, Harminder; Faraj, Lana

2012-06-01

Corneal Ulcers are a common eye disease that requires prompt treatment. Recently a number of treatment approaches have been introduced that have been proven to be very effective. Unfortunately, the monitoring process of the treatment procedure remains manual and hence time consuming and prone to human errors. In this research we propose an automatic image analysis based approach to measure the size of an ulcer and its subsequent further investigation to determine the effectiveness of any treatment process followed. In Ophthalmology an ulcer area is detected for further inspection via luminous excitation of a dye. Usually in the imaging systems utilised for this purpose (i.e. a slit lamp with an appropriate dye) the ulcer area is excited to be luminous green in colour as compared to rest of the cornea which appears blue/brown. In the proposed approach we analyse the image in the HVS colour space. Initially a pre-processing stage that carries out a local histogram equalisation is used to bring back detail in any over or under exposed areas. Secondly we deal with the removal of potential reflections from the affected areas by making use of image registration of two candidate corneal images based on the detected corneal areas. Thirdly the exact corneal boundary is detected by initially registering an ellipse to the candidate corneal boundary detected via edge detection and subsequently allowing the user to modify the boundary to overlap with the boundary of the ulcer being observed. Although this step makes the approach semi automatic, it removes the impact of breakages of the corneal boundary due to occlusion, noise, image quality degradations. The ratio between the ulcer area confined within the corneal area to the corneal area is used as a measure of comparison. We demonstrate the use of the proposed tool in the analysis of the effectiveness of a treatment procedure adopted for corneal ulcers in patients by comparing the variation of corneal size over time.

A second-order orientation-contrast stimulus for population-receptive-field-based retinotopic mapping.

PubMed

Yildirim, Funda; Carvalho, Joana; Cornelissen, Frans W

2018-01-01

Visual field or retinotopic mapping is one of the most frequently used paradigms in fMRI. It uses activity evoked by position-varying high luminance contrast visual patterns presented throughout the visual field for determining the spatial organization of cortical visual areas. While the advantage of using high luminance contrast is that it tends to drive a wide range of neural populations - thus resulting in high signal-to-noise BOLD responses - this may also be a limitation, especially for approaches that attempt to squeeze more information out of the BOLD response, such as population receptive field (pRF) mapping. In that case, more selective stimulation of a subset of neurons - despite reduced signals - could result in better characterization of pRF properties. Here, we used a second-order stimulus based on local differences in orientation texture - to which we refer as orientation contrast - to perform retinotopic mapping. Participants in our experiment viewed arrays of Gabor patches composed of a foreground (a bar) and a background. These could only be distinguished on the basis of a difference in patch orientation. In our analyses, we compare the pRF properties obtained using this new orientation contrast-based retinotopy (OCR) to those obtained using classic luminance contrast-based retinotopy (LCR). Specifically, in higher order cortical visual areas such as LO, our novel approach resulted in non-trivial reductions in estimated population receptive field size of around 30%. A set of control experiments confirms that the most plausible cause for this reduction is that OCR mainly drives neurons sensitive to orientation contrast. We discuss how OCR - by limiting receptive field scatter and reducing BOLD displacement - may result in more accurate pRF localization as well. Estimation of neuronal properties is crucial for interpreting cortical function. Therefore, we conclude that using our approach, it is possible to selectively target particular neuronal populations, opening the way to use pRF modeling to dissect the response properties of more clearly-defined neuronal populations in different visual areas. Copyright © 2017 Elsevier Inc. All rights reserved.

Effect of ascorbic acid on endothelial dysfunction of epicardial coronary arteries in chronic smokers assessed by cold pressor testing.

PubMed

Schindler, T H; Magosaki, N; Jeserich, M; Olschewski, M; Nitzsche, E; Holubarsch, C; Solzbach, U; Just, H

2000-01-01

In chronic smokers there is evidence for increased formation of oxygen-derived free radicals within the vessel wall impairing endothelial function. It has been suggested that the inactivation of endothelium-derived nitric oxide by oxygen free radicals contributes to endothelial dysfunction. Hence, we tested the hypothesis that in chronic smokers the antioxidant ascorbic acid could improve abnormal endothelial function of epicardial coronary arteries. Thirty-one patients (mean age 57 +/- 9 years) referred for routine diagnostic catheterization for evaluation of chest pain and without angiographically significant coronary artery stenoses were randomly assigned to one of the study groups to assess vasomotor response of epicardial coronary arteries due to cold pressor testing (CPT) before and after intravenous infusion of 3 g of ascorbic acid or 100 ml x 0.9% saline infusion. In 6 controls (mean age 55 +/- 3 years) CPT led to a similar increase in luminal area before and after ascorbic acid administration (26.5 +/- 15.0 vs. 28.4 +/- 17.7%, p = NS). In 15 chronic smokers (mean age 55 +/- 9 years), CPT induced a decrease in the luminal area of -18.5 +/- 6.3%. This flow-dependent vasoconstriction was significantly reversed to 7.7 +/- 6.2% (p < or = 0.03) vasodilation after intravenous ascorbic acid administration. In 10 chronic smokers (mean age 57 +/- 11 years) saline infusion (placebo) did not have a significant effect on CPT-induced vasoconstriction (-12.7 +/- 5.1 vs. -13.1 +/- 5.1%, p = NS). The CPT-induced increase in luminal area in chronic smokers after ascorbic acid infusion was significant compared to controls and placebo (each p < or = 0.05). Our assessment of endothelium-independent responses to nitroglycerin revealed no significant differences between the single study groups (p = NS). In chronic smokers acute intravenous administration of ascorbic acid significantly improves CPT-induced coronary endothelium-dependent dysfunction. According to the current understanding, this effect is due to improved cellular redox imbalance and prevention of nitric oxide inactivation in the endothelium and subendothelial space.

Maximizing optical efficacy and color gamut in projection applications by combining four laser wavelengths

NASA Astrophysics Data System (ADS)

Wallhead, Ian; Ocaña, Roberto

2014-05-01

Laser projection devices should be designed to maximize their luminous efficacy and color gamut. This is for two main reasons. Firstly, being either stand alone devices or embedded in other products, they could be powered by battery, and lifetime is an important factor. Secondly, the increasing use of lasers to project images calls for a consideration of eye safety issues. The brightness of the projected image may be limited by the Class II accessible emission limit. There is reason to believe that current laser beam scanning projection technology is already close to the power ceiling based on eye safety limits. Consequently, it would be desirable to improve luminous efficacy to increase the output luminous flux whilst maintaining or improving color gamut for the same eye-safe optical power limit. Here we present a novel study about the combination of four laser wavelengths in order to maximize both color gamut and efficacy to produce the color white. Firstly, an analytic method to calculate efficacy as function of both four laser wavelengths and four laser powers is derived. Secondly we provide a new way to present the results by providing the diagram efficacy vs color gamut area that summarizes the performance of any wavelength combination for projection purposes. The results indicate that the maximal efficacy for the D65 white is only achievable by using a suitable combination of both laser power ratios and wavelengths.

The clustering evolution of distant red galaxies in the GOODS-MUSIC sample

NASA Astrophysics Data System (ADS)

Grazian, A.; Fontana, A.; Moscardini, L.; Salimbeni, S.; Menci, N.; Giallongo, E.; de Santis, C.; Gallozzi, S.; Nonino, M.; Cristiani, S.; Vanzella, E.

2006-07-01

Aims.We study the clustering properties of Distant Red Galaxies (DRGs) to test whether they are the progenitors of local massive galaxies. Methods.We use the GOODS-MUSIC sample, a catalog of ~3000 Ks-selected galaxies based on VLT and HST observation of the GOODS-South field with extended multi-wavelength coverage (from 0.3 to 8~μm) and accurate estimates of the photometric redshifts to select 179 DRGs with J-Ks≥ 1.3 in an area of 135 sq. arcmin.Results.We first show that the J-Ks≥ 1.3 criterion selects a rather heterogeneous sample of galaxies, going from the targeted high-redshift luminous evolved systems, to a significant fraction of lower redshift (1

Long time stability of lamps with nanostructural carbon field emission cathodes

NASA Astrophysics Data System (ADS)

Kalenik, J.; Firek, P.; Szmidt, J.; Czerwosz, E.; Kozłowski, M.; Stepińska, I.; Wódka, T.

2017-08-01

A luminescent lamp with field emission cathode was constructed and tested. Phosphor excited by electrons from field emission cathode is the source of light. The cathode is covered with nickel-carbon film containing multilayer carbon nanotubes that enhance electron emission from the cathode. Results of luminance stability measurements are presented. Luminance of elaborated luminance lamp is high enough for lighting application. Long term stability (1000 hours) is satisfactory for mass lamp application. Initial short time decrease of luminance is still too high and it needs reduction.

Psychological Effect of Daylighting on Behavior

NASA Astrophysics Data System (ADS)

Oyama, Yoshie

In order to facilitate use of daylighting in architectural design, we tried to measure the suitability of luminous environment for various behavior, including not only visual work but also refreshing and rest. An experiment was conducted with 7 luminous conditions including daylighting. The suitability of a luminous environment was measured by asking the subjects to select suitable activities and unsuitable behaviors from a given list of possible activities. The result showed the selection of unsuitable behaviors was more useful than the selection of suitable behaviors. Furthermore, lighting installations offering a steady luminous environments, were not suitable for many behaviors including refreshing and rest. The luminous environments which were bright but had some fluctuation and some non-uniformity of brightness, obtained by use of direct sunlight, were judged to be suitable for negotiating, refreshing, and meeting.

When do luminance changes capture attention?

PubMed

Spehar, Branka; Owens, Caleb

2012-05-01

In two experiments, we examined the ability of task-irrelevant changes in luminance to capture attention in an irrelevant singleton search. By using uniform increment and decrement arrays, we were able to create changes of the same absolute magnitude, but resulting in a singleton with either higher or lower contrast magnitude, relative to other elements in the search array. A condition where a singleton changed contrast polarity without a concomitant change in the overall contrast magnitude was also included. It was found that only luminance changes resulting in a singleton having increased contrast (or saliency) were effective in capturing attention. In addition, no attentional capture was observed when the irrelevant singleton was characterized by the equivalent amount of static luminance differences, suggesting a unique attentional prioritization of luminance changes that increase singleton saliency.

Study on the luminous characteristics of a natural ball lightning

NASA Astrophysics Data System (ADS)

Wang, Hao; Yuan, Ping; Cen, Jianyong; Liu, Guorong

2018-02-01

According to the optical images of the whole process of a natural ball lightning recorded by two slit-less spectrographs in the Qinghai plateau of China, the simulated observation experiment on the luminous intensity of the spherical light source was carried out. The luminous intensity and the optical power of the natural ball lightning in the wavelength range of 400-690 nm were estimated based on the experimental data and the Lambert-Beer Law. The results show that the maximum luminous intensity was about 1.24 × 105 cd in the initial stage of the natural ball lightning, and the maximum luminous intensity and the maximum optical power in most time of its life were about 5.9 × 104 cd and 4.2 × 103 W, respectively.

Luminous Efficiency Estimates of Meteors. II. Application to Canadian Automated Meteor Observatory Meteor Events

NASA Astrophysics Data System (ADS)

Subasinghe, Dilini; Campbell-Brown, Margaret

2018-02-01

Luminous efficiency is a necessary parameter for determining meteoroid mass from optical emission. Despite this importance, it is very poorly known, with previous results varying by up to two orders of magnitude for a given speed. We present the most recent study of luminous efficiency values determined with modern high-resolution instruments, by directly comparing dynamic and photometric meteoroid masses. Fifteen non-fragmenting meteoroids were used, with a further five clearly fragmenting events for comparison. Twelve of the fifteen non-fragmenting meteoroids had luminous efficiencies less than 1%, while the fragmenting meteoroids had upper limits of a few tens of per cent. No clear trend with speed was seen, but there was a weak negative trend of luminous efficiency on meteoroid mass, implying that smaller meteoroids radiate more efficiently.

Simultaneous chromatic and luminance human electroretinogram responses.

PubMed

Parry, Neil R A; Murray, Ian J; Panorgias, Athanasios; McKeefry, Declan J; Lee, Barry B; Kremers, Jan

2012-07-01

The parallel processing of information forms an important organisational principle of the primate visual system. Here we describe experiments which use a novel chromatic–achromatic temporal compound stimulus to simultaneously identify colour and luminance specific signals in the human electroretinogram (ERG). Luminance and chromatic components are separated in the stimulus; the luminance modulation has twice the temporal frequency of the chromatic modulation. ERGs were recorded from four trichromatic and two dichromatic subjects (1 deuteranope and 1 protanope). At isoluminance, the fundamental (first harmonic) response was elicited by the chromatic component in the stimulus. The trichromatic ERGs possessed low-pass temporal tuning characteristics, reflecting the activity of parvocellular post-receptoral mechanisms. There was very little first harmonic response in the dichromats' ERGs. The second harmonic response was elicited by the luminance modulation in the compound stimulus and showed, in all subjects, band-pass temporal tuning characteristic of magnocellular activity. Thus it is possible to concurrently elicit ERG responses from the human retina which reflect processing in both chromatic and luminance pathways. As well as providing a clear demonstration of the parallel nature of chromatic and luminance processing in the human retina, the differences that exist between ERGs from trichromatic and dichromatic subjects point to the existence of interactions between afferent post-receptoral pathways that are in operation from the earliest stages of visual processing.

Dynamics of backlight luminance for using smartphone in dark environment

NASA Astrophysics Data System (ADS)

Na, Nooree; Jang, Jiho; Suk, Hyeon-Jeong

2014-02-01

This study developed dynamic backlight luminance, which gradually changes as time passes for comfortable use of a smartphone display in a dark environment. The study was carried out in two stages. In the first stage, a user test was conducted to identify the optimal luminance by assessing the facial squint level, subjective glare evaluation, eye blink frequency and users' subjective preferences. Based on the results of the user test, the dynamics of backlight luminance was designed. It has two levels of luminance: the optimal level for initial viewing to avoid sudden glare or fatigue to users' eyes, and the optimal level for constant viewing, which is comfortable, but also bright enough for constant reading of the displayed material. The luminance for initial viewing starts from 10 cd/m2, and it gradually increases to 40 cd/m2 for users' visual comfort at constant viewing for 20 seconds; In the second stage, a validation test on dynamics of backlight luminance was conducted to verify the effectiveness of the developed dynamics. It involving users' subjective preferences, eye blink frequency, and brainwave analysis using the electroencephalogram (EEG) to confirm that the proposed dynamic backlighting enhances users' visual comfort and visual cognition, particularly for using smartphones in a dark environment.

Neuronal mechanisms underlying differences in spatial resolution between darks and lights in human vision.

PubMed

Pons, Carmen; Mazade, Reece; Jin, Jianzhong; Dul, Mitchell W; Zaidi, Qasim; Alonso, Jose-Manuel

2017-12-01

Artists and astronomers noticed centuries ago that humans perceive dark features in an image differently from light ones; however, the neuronal mechanisms underlying these dark/light asymmetries remained unknown. Based on computational modeling of neuronal responses, we have previously proposed that such perceptual dark/light asymmetries originate from a luminance/response saturation within the ON retinal pathway. Consistent with this prediction, here we show that stimulus conditions that increase ON luminance/response saturation (e.g., dark backgrounds) or its effect on light stimuli (e.g., optical blur) impair the perceptual discrimination and salience of light targets more than dark targets in human vision. We also show that, in cat visual cortex, the magnitude of the ON luminance/response saturation remains relatively constant under a wide range of luminance conditions that are common indoors, and only shifts away from the lowest luminance contrasts under low mesopic light. Finally, we show that the ON luminance/response saturation affects visual salience mostly when the high spatial frequencies of the image are reduced by poor illumination or optical blur. Because both low luminance and optical blur are risk factors in myopia, our results suggest a possible neuronal mechanism linking myopia progression with the function of the ON visual pathway.

Neuronal mechanisms underlying differences in spatial resolution between darks and lights in human vision

PubMed Central

Pons, Carmen; Mazade, Reece; Jin, Jianzhong; Dul, Mitchell W.; Zaidi, Qasim; Alonso, Jose-Manuel

2017-01-01

Artists and astronomers noticed centuries ago that humans perceive dark features in an image differently from light ones; however, the neuronal mechanisms underlying these dark/light asymmetries remained unknown. Based on computational modeling of neuronal responses, we have previously proposed that such perceptual dark/light asymmetries originate from a luminance/response saturation within the ON retinal pathway. Consistent with this prediction, here we show that stimulus conditions that increase ON luminance/response saturation (e.g., dark backgrounds) or its effect on light stimuli (e.g., optical blur) impair the perceptual discrimination and salience of light targets more than dark targets in human vision. We also show that, in cat visual cortex, the magnitude of the ON luminance/response saturation remains relatively constant under a wide range of luminance conditions that are common indoors, and only shifts away from the lowest luminance contrasts under low mesopic light. Finally, we show that the ON luminance/response saturation affects visual salience mostly when the high spatial frequencies of the image are reduced by poor illumination or optical blur. Because both low luminance and optical blur are risk factors in myopia, our results suggest a possible neuronal mechanism linking myopia progression with the function of the ON visual pathway. PMID:29196762

Luminance requirements for lighted signage

NASA Astrophysics Data System (ADS)

Freyssinier, Jean Paul; Narendran, Nadarajah; Bullough, John D.

2006-08-01

Light-emitting diode (LED) technology is presently targeted to displace traditional light sources in backlighted signage. The literature shows that brightness and contrast are perhaps the two most important elements of a sign that determine its attention-getting capabilities and its legibility. Presently, there are no luminance standards for signage, and the practice of developing brighter signs to compete with signs in adjacent businesses is becoming more commonplace. Sign luminances in such cases may far exceed what people usually need for identifying and reading a sign. Furthermore, the practice of higher sign luminance than needed has many negative consequences, including higher energy use and light pollution. To move toward development of a recommendation for lighted signage, several laboratory human factors evaluations were conducted. A scale model of a storefront was used to present human subjects with a typical red channel-letter sign at luminances ranging from 8 cd/m2 to 1512 cd/m2 under four background luminances typical of nighttime outdoor and daytime inside-mall conditions (1, 100, 300, 1000 cd/m2), from three scaled viewing distances (30, 60, 340 ft), and either in isolation or adjacent to two similar signs. Subjects rated the brightness, acceptability, and ease of reading of the test sign for each combination of sign and background luminances and scaled viewing distances.

The role of luminance and chromatic cues in emmetropisation.

PubMed

Rucker, Frances J

2013-05-01

At birth most, but not all eyes, are hyperopic. Over the course of the first few years of life the refraction gradually becomes close to zero through a process called emmetropisation. This process is not thought to require accommodation, though a lag of accommodation has been implicated in myopia development, suggesting that the accuracy of accommodation is an important factor. This review will cover research on accommodation and emmetropisation that relates to the ability of the eye to use colour and luminance cues to guide the responses. There are three ways in which changes in luminance and colour contrast could provide cues: (1) The eye could maximize luminance contrast. Monochromatic light experiments have shown that the human eye can accommodate and animal eyes can emmetropise using changes in luminance contrast alone. However, by reducing the effectiveness of luminance cues in monochromatic and white light by introducing astigmatism, or by reducing light intensity, investigators have revealed that the eye also uses colour cues in emmetropisation. (2) The eye could compare relative cone contrast to derive the sign of defocus information from colour cues. Experiments involving simulations of the retinal image with defocus have shown that relative cone contrast can provide colour cues for defocus in accommodation and emmetropisation. In the myopic simulation the contrast of the red component of a sinusoidal grating was higher than that of the green and blue component and this caused relaxation of accommodation and reduced eye growth. In the hyperopic simulation the contrast of the blue component was higher than that of the green and red components and this caused increased accommodation and increased eye growth. (3) The eye could compare the change in luminance and colour contrast as the eye changes focus. An experiment has shown that changes in colour or luminance contrast can provide cues for defocus in emmetropisation. When the eye is exposed to colour flicker the eye grows almost twice as much, and becomes more myopic, compared to when the eye is exposed to luminance flicker. Neural responses of the luminance and colour mechanisms direct accommodation and emmetropisation mechanisms to different focal planes. Therefore, it is likely that the set point of refraction and accommodation is dependent on the sensitivity of the eye to changes in spatial and temporal, colour and luminance contrast. Ophthalmic & Physiological Optics © 2013 The College of Optometrists.

Is switching from brand name to generic formulations of phenobarbital associated with loss of antiepileptic efficacy?: a pharmacokinetic study with two oral formulations (Luminal(®) vet, Phenoleptil(®)) in dogs.

PubMed

Bankstahl, Marion; Bankstahl, Jens P; Löscher, Wolfgang

2013-10-09

In human medicine, adverse outcomes associated with switching between bioequivalent brand name and generic antiepileptic drug products is a subject of concern among clinicians. In veterinary medicine, epilepsy in dogs is usually treated with phenobarbital, either with the standard brand name formulation Luminal(®) or the veterinary products Luminal(®) vet and the generic formulation Phenoleptil(®). Luminal(®) and Luminal(®) vet are identical 100 mg tablet formulations, while Phenoleptil(®) is available in the form of 12.5 and 50 mg tablets. Following approval of Phenoleptil(®) for treatment of canine epilepsy, it was repeatedly reported by clinicians and dog owners that switching from Luminal(®) (human tablets) to Phenoleptil(®) in epileptic dogs, which were controlled by treatment with Luminal(®), induced recurrence of seizures. In the present study, we compared bioavailability of phenobarbital after single dose administration of Luminal(®) vet vs. Phenoleptil(®) with a crossover design in 8 healthy Beagle dogs. Both drugs were administered at a dose of 100 mg/dog, resulting in 8 mg/kg phenobarbital on average. Peak plasma concentrations (Cmax) following Luminal(®) vet vs. Phenoleptil(®) were about the same in most dogs (10.9 ± 0.92 vs. 10.5 ± 0.77 μg/ml), and only one dog showed noticeable lower concentrations after Phenoleptil(®) vs. Luminal(®) vet. Elimination half-life was about 50 h (50.3 ± 3.1 vs. 52.9 ± 2.8 h) without differences between the formulations. The relative bioavailability of the two products (Phenoleptil(®) vs. Luminal(®) vet.) was 0.98 ± 0.031, indicating that both formulations resulted in about the same bioavailability. Overall, the two formulations did not differ significantly with respect to pharmacokinetic parameters when mean group parameters were compared. Thus, the reasons for the anecdotal reports, if true, that switching from the brand to the generic formulation of phenobarbital may lead to recurrence of seizures are obviously not related to a generally lower bioavailability of the generic formulation, although single dogs may exhibit lower plasma levels after the generic formulation that could be clinically meaningful.

Is switching from brand name to generic formulations of phenobarbital associated with loss of antiepileptic efficacy?: a pharmacokinetic study with two oral formulations (Luminal® vet, Phenoleptil®) in dogs

PubMed Central

2013-01-01

Background In human medicine, adverse outcomes associated with switching between bioequivalent brand name and generic antiepileptic drug products is a subject of concern among clinicians. In veterinary medicine, epilepsy in dogs is usually treated with phenobarbital, either with the standard brand name formulation Luminal® or the veterinary products Luminal® vet and the generic formulation Phenoleptil®. Luminal® and Luminal® vet are identical 100 mg tablet formulations, while Phenoleptil® is available in the form of 12.5 and 50 mg tablets. Following approval of Phenoleptil® for treatment of canine epilepsy, it was repeatedly reported by clinicians and dog owners that switching from Luminal® (human tablets) to Phenoleptil® in epileptic dogs, which were controlled by treatment with Luminal®, induced recurrence of seizures. In the present study, we compared bioavailability of phenobarbital after single dose administration of Luminal® vet vs. Phenoleptil® with a crossover design in 8 healthy Beagle dogs. Both drugs were administered at a dose of 100 mg/dog, resulting in 8 mg/kg phenobarbital on average. Results Peak plasma concentrations (Cmax) following Luminal® vet vs. Phenoleptil® were about the same in most dogs (10.9 ± 0.92 vs. 10.5 ± 0.77 μg/ml), and only one dog showed noticeable lower concentrations after Phenoleptil® vs. Luminal® vet. Elimination half-life was about 50 h (50.3 ± 3.1 vs. 52.9 ± 2.8 h) without differences between the formulations. The relative bioavailability of the two products (Phenoleptil® vs. Luminal® vet.) was 0.98 ± 0.031, indicating that both formulations resulted in about the same bioavailability. Conclusions Overall, the two formulations did not differ significantly with respect to pharmacokinetic parameters when mean group parameters were compared. Thus, the reasons for the anecdotal reports, if true, that switching from the brand to the generic formulation of phenobarbital may lead to recurrence of seizures are obviously not related to a generally lower bioavailability of the generic formulation, although single dogs may exhibit lower plasma levels after the generic formulation that could be clinically meaningful. PMID:24107313

MINIMUM AREAS FOR ELEMENTARY SCHOOL BUILDING FACILITIES.

ERIC Educational Resources Information Center

Pennsylvania State Dept. of Public Instruction, Harrisburg.

MINIMUM AREA SPACE REQUIREMENTS IN SQUARE FOOTAGE FOR ELEMENTARY SCHOOL BUILDING FACILITIES ARE PRESENTED, INCLUDING FACILITIES FOR INSTRUCTIONAL USE, GENERAL USE, AND SERVICE USE. LIBRARY, CAFETERIA, KITCHEN, STORAGE, AND MULTIPURPOSE ROOMS SHOULD BE SIZED FOR THE PROJECTED ENROLLMENT OF THE BUILDING IN ACCORDANCE WITH THE PROJECTION UNDER THE…

High-speed photometry of the eclipsing dwarf nova OY Carinae

NASA Technical Reports Server (NTRS)

Cook, M. C.

1985-01-01

High-speed photometry of the eclipsing dwarf nova OY Car in the quiescent state is presented. OY Car becomes highly reddened during eclipse, with minimum flux colours inconsistent with optically thick emission in the U and B bandpasses. Mass ratios in the range 6.5 to 12 are required to reconcile the eclipse structure with theoretical gas stream trajectories. Primary eclipse timings reveal a significant decrease in the orbital period and the duration of primary eclipse indicates the presence of a luminous ring about the white dwarf. The hotspot eclipse reveals a hotspot which is elongated along the rim of the accretion disc, with optical emission being non-uniformly distributed along the rim. The location of the hotspot in the accretion disc implies a disc radius larger than that of an inviscid disc, with variation in the position of the hotspot being consistent with a fixed stream trajectory.

The integrative epigenomic-transcriptomic landscape of ER positive breast cancer.

PubMed

Gao, Yang; Jones, Allison; Fasching, Peter A; Ruebner, Matthias; Beckmann, Matthias W; Widschwendter, Martin; Teschendorff, Andrew E

2015-01-01

While recent integrative analyses of copy number and gene expression data in breast cancer have revealed a complex molecular landscape with multiple subtypes and many oncogenic/tumour suppressor driver events, much less is known about the role of DNA methylation in shaping breast cancer taxonomy and defining driver events. Here, we applied a powerful integrative network algorithm to matched DNA methylation and RNA-Seq data for 724 estrogen receptor (ER)-positive (ER+) breast cancers and 111 normal adjacent tissue specimens from The Cancer Genome Atlas (TCGA) project, in order to identify putative epigenetic driver events and to explore the resulting molecular taxonomy. This revealed the existence of nine functionally deregulated epigenetic hotspots encompassing a total of 146 genes, which we were able to validate in independent data sets encompassing over 1000 ER+ breast cancers. Integrative clustering of the matched messenger RNA (mRNA) and DNA methylation data over these genes resulted in only two clusters, which correlated very strongly with the luminal-A and luminal B subtypes. Overall, luminal-A and luminal-B breast cancers shared the same epigenetically deregulated hotspots but with luminal-B cancers exhibiting increased aberrant DNA methylation patterns relative to normal tissue. We show that increased levels of DNA methylation and mRNA expression deviation from the normal state define a marker of poor prognosis. Our data further implicates epigenetic silencing of WNT signalling antagonists and bone morphogenetic proteins (BMP) as key events underlying both luminal subtypes but specially of luminal-B breast cancer. Finally, we show that DNA methylation changes within the identified epigenetic interactome hotspots do not exhibit mutually exclusive patterns within the same cancer sample, instead exhibiting coordinated changes within the sample. Our results indicate that the integrative DNA methylation and transcriptomic landscape of ER+ breast cancer is surprisingly homogeneous, defining two main subtypes which strongly correlate with luminal-A/B subtype status. In particular, we identify WNT and BMP signalling as key epigenetically deregulated tumour suppressor pathways in luminal ER+ breast cancer, with increased deregulation seen in luminal-B breast cancer.

Patterns of breast cancer relapse in accordance to biological subtype.

PubMed

Ignatov, Atanas; Eggemann, Holm; Burger, Elke; Ignatov, Tanja

2018-04-19

To evaluate the pattern of recurrence of breast cancer according to its biological subtype in a large cohort of patients treated with therapy representative of current practice. Patients treated between 2000 and 2016 with known biological subtype were eligible. Data were prospectively collected. Primary endpoint was the subtype-dependent pattern and time of recurrence. Loco-regional and distant site and time of recurrence were assessed. Median follow-up time was 80.8 months. For 12,053 (82.5%) of 14,595 patients with primary non-metastatic invasive breast cancer a subtype classification was possible. The luminal A subtype had the highest 10-year survival followed by luminal B and luminal/HER2. The worst survival demonstrated HER2 enriched and TNBC. HER2 and TNBC had the highest rate of recurrence in the first 5 years, whereas the rate of recurrence for luminal A and luminal B tumors was initially low, but remained continuously even after 10 years of follow-up. Luminal A tumors demonstrated the lowest rate of distant metastases predominantly in bone. So did luminal B tumors. HER2 enriched subtype was characterized with increased rate of loco-regional recurrence and distant metastases in bone, liver and brain. Luminal/HER2 had pattern of relapse similar to HER2 enriched tumors, with exception of loco-regional relapse and brain metastases. TNBC had higher rate of lung, bone and brain metastases as well as loco-regional relapse. Breast cancer subtypes are associated with different time and pattern of recurrence and it should be considered during treatment decision.

14 CFR 91.177 - Minimum altitudes for IFR operations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... mountainous area in part 95 of this chapter, an altitude of 2,000 feet above the highest obstacle within a... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Minimum altitudes for IFR operations. 91... Instrument Flight Rules § 91.177 Minimum altitudes for IFR operations. (a) Operation of aircraft at minimum...

A True-Color Sensor and Suitable Evaluation Algorithm for Plant Recognition

PubMed Central

Schmittmann, Oliver; Schulze Lammers, Peter

2017-01-01

Plant-specific herbicide application requires sensor systems for plant recognition and differentiation. A literature review reveals a lack of sensor systems capable of recognizing small weeds in early stages of development (in the two- or four-leaf stage) and crop plants, of making spraying decisions in real time and, in addition, are that are inexpensive and ready for practical use in sprayers. The system described in this work is based on free cascadable and programmable true-color sensors for real-time recognition and identification of individual weed and crop plants. The application of this type of sensor is suitable for municipal areas and farmland with and without crops to perform the site-specific application of herbicides. Initially, databases with reflection properties of plants, natural and artificial backgrounds were created. Crop and weed plants should be recognized by the use of mathematical algorithms and decision models based on these data. They include the characteristic color spectrum, as well as the reflectance characteristics of unvegetated areas and areas with organic material. The CIE-Lab color-space was chosen for color matching because it contains information not only about coloration (a- and b-channel), but also about luminance (L-channel), thus increasing accuracy. Four different decision making algorithms based on different parameters are explained: (i) color similarity (ΔE); (ii) color similarity split in ΔL, Δa and Δb; (iii) a virtual channel ‘d’ and (iv) statistical distribution of the differences of reflection backgrounds and plants. Afterwards, the detection success of the recognition system is described. Furthermore, the minimum weed/plant coverage of the measuring spot was calculated by a mathematical model. Plants with a size of 1–5% of the spot can be recognized, and weeds in the two-leaf stage can be identified with a measuring spot size of 5 cm. By choosing a decision model previously, the detection quality can be increased. Depending on the characteristics of the background, different models are suitable. Finally, the results of field trials on municipal areas (with models of plants), winter wheat fields (with artificial plants) and grassland (with dock) are shown. In each experimental variant, objects and weeds could be recognized. PMID:28786922

A True-Color Sensor and Suitable Evaluation Algorithm for Plant Recognition.

PubMed

Schmittmann, Oliver; Schulze Lammers, Peter

2017-08-08

Plant-specific herbicide application requires sensor systems for plant recognition and differentiation. A literature review reveals a lack of sensor systems capable of recognizing small weeds in early stages of development (in the two- or four-leaf stage) and crop plants, of making spraying decisions in real time and, in addition, are that are inexpensive and ready for practical use in sprayers. The system described in this work is based on free cascadable and programmable true-color sensors for real-time recognition and identification of individual weed and crop plants. The application of this type of sensor is suitable for municipal areas and farmland with and without crops to perform the site-specific application of herbicides. Initially, databases with reflection properties of plants, natural and artificial backgrounds were created. Crop and weed plants should be recognized by the use of mathematical algorithms and decision models based on these data. They include the characteristic color spectrum, as well as the reflectance characteristics of unvegetated areas and areas with organic material. The CIE-Lab color-space was chosen for color matching because it contains information not only about coloration (a- and b-channel), but also about luminance (L-channel), thus increasing accuracy. Four different decision making algorithms based on different parameters are explained: (i) color similarity (ΔE); (ii) color similarity split in ΔL, Δa and Δb; (iii) a virtual channel 'd' and (iv) statistical distribution of the differences of reflection backgrounds and plants. Afterwards, the detection success of the recognition system is described. Furthermore, the minimum weed/plant coverage of the measuring spot was calculated by a mathematical model. Plants with a size of 1-5% of the spot can be recognized, and weeds in the two-leaf stage can be identified with a measuring spot size of 5 cm. By choosing a decision model previously, the detection quality can be increased. Depending on the characteristics of the background, different models are suitable. Finally, the results of field trials on municipal areas (with models of plants), winter wheat fields (with artificial plants) and grassland (with dock) are shown. In each experimental variant, objects and weeds could be recognized.

Covariation of Color and Luminance Facilitate Object Individuation in Infancy

ERIC Educational Resources Information Center

Woods, Rebecca J.; Wilcox, Teresa

2010-01-01

The ability to individuate objects is one of our most fundamental cognitive capacities. Recent research has revealed that when objects vary in color or luminance alone, infants fail to individuate those objects until 11.5 months. However, color and luminance frequently covary in the natural environment, thus providing a more salient and reliable…

Paracrine Met signaling triggers epithelial–mesenchymal transition in mammary luminal progenitors, affecting their fate

PubMed Central

Di-Cicco, Amandine; Petit, Valérie; Chiche, Aurélie; Bresson, Laura; Romagnoli, Mathilde; Orian-Rousseau, Véronique; Vivanco, Maria dM; Medina, Daniel; Faraldo, Marisa M; Glukhova, Marina A; Deugnier, Marie-Ange

2015-01-01

HGF/Met signaling has recently been associated with basal-type breast cancers, which are thought to originate from progenitor cells residing in the luminal compartment of the mammary epithelium. We found that ICAM-1 efficiently marks mammary luminal progenitors comprising hormone receptor-positive and receptor-negative cells, presumably ductal and alveolar progenitors. Both cell populations strongly express Met, while HGF is produced by stromal and basal myoepithelial cells. We show that persistent HGF treatment stimulates the clonogenic activity of ICAM1-positive luminal progenitors, controlling their survival and proliferation, and leads to the expression of basal cell characteristics, including stem cell potential. This is accompanied by the induction of Snai1 and Snai2, two major transcription factors triggering epithelial–mesenchymal transition, the repression of the luminal-regulatory genes Elf5 and Hey1, and claudin down-regulation. Our data strongly indicate that paracrine Met signaling can control the function of luminal progenitors and modulate their fate during mammary development and tumorigenesis. DOI: http://dx.doi.org/10.7554/eLife.06104.001 PMID:26165517

Quantitative diffusion weighted imaging parameters in tumor and peritumoral stroma for prediction of molecular subtypes in breast cancer

NASA Astrophysics Data System (ADS)

He, Ting; Fan, Ming; Zhang, Peng; Li, Hui; Zhang, Juan; Shao, Guoliang; Li, Lihua

2018-03-01

Breast cancer can be classified into four molecular subtypes of Luminal A, Luminal B, HER2 and Basal-like, which have significant differences in treatment and survival outcomes. We in this study aim to predict immunohistochemistry (IHC) determined molecular subtypes of breast cancer using image features derived from tumor and peritumoral stroma region based on diffusion weighted imaging (DWI). A dataset of 126 breast cancer patients were collected who underwent preoperative breast MRI with a 3T scanner. The apparent diffusion coefficients (ADCs) were recorded from DWI, and breast image was segmented into regions comprising the tumor and the surrounding stromal. Statistical characteristics in various breast tumor and peritumoral regions were computed, including mean, minimum, maximum, variance, interquartile range, range, skewness, and kurtosis of ADC values. Additionally, the difference of features between each two regions were also calculated. The univariate logistic based classifier was performed for evaluating the performance of the individual features for discriminating subtypes. For multi-class classification, multivariate logistic regression model was trained and validated. The results showed that the tumor boundary and proximal peritumoral stroma region derived features have a higher performance in classification compared to that of the other regions. Furthermore, the prediction model using statistical features, difference features and all the features combined from these regions generated AUC values of 0.774, 0.796 and 0.811, respectively. The results in this study indicate that ADC feature in tumor and peritumoral stromal region would be valuable for estimating the molecular subtype in breast cancer.

Could the peristaltic transition zone be caused by non-uniform esophageal muscle fiber architecture? A simulation study.

PubMed

Kou, W; Pandolfino, J E; Kahrilas, P J; Patankar, N A

2017-06-01

Based on a fully coupled computational model of esophageal transport, we analyzed how varied esophageal muscle fiber architecture and/or dual contraction waves (CWs) affect bolus transport. Specifically, we studied the luminal pressure profile in those cases to better understand possible origins of the peristaltic transition zone. Two groups of studies were conducted using a computational model. The first studied esophageal transport with circumferential-longitudinal fiber architecture, helical fiber architecture and various combinations of the two. In the second group, cases with dual CWs and varied muscle fiber architecture were simulated. Overall transport characteristics were examined and the space-time profiles of luminal pressure were plotted and compared. Helical muscle fiber architecture featured reduced circumferential wall stress, greater esophageal distensibility, and greater axial shortening. Non-uniform fiber architecture featured a peristaltic pressure trough between two high-pressure segments. The distal pressure segment showed greater amplitude than the proximal segment, consistent with experimental data. Dual CWs also featured a pressure trough between two high-pressure segments. However, the minimum pressure in the region of overlap was much lower, and the amplitudes of the two high-pressure segments were similar. The efficacy of esophageal transport is greatly affected by muscle fiber architecture. The peristaltic transition zone may be attributable to non-uniform architecture of muscle fibers along the length of the esophagus and/or dual CWs. The difference in amplitude between the proximal and distal pressure segments may be attributable to non-uniform muscle fiber architecture. © 2017 John Wiley & Sons Ltd.

Assessing Seasonal and Inter-Annual Variations of Lake Surface Areas in Mongolia during 2000-2011 Using Minimum Composite MODIS NDVI

PubMed Central

Kang, Sinkyu; Hong, Suk Young

2016-01-01

A minimum composite method was applied to produce a 15-day interval normalized difference vegetation index (NDVI) dataset from Moderate Resolution Imaging Spectroradiometer (MODIS) daily 250 m reflectance in the red and near-infrared bands. This dataset was applied to determine lake surface areas in Mongolia. A total of 73 lakes greater than 6.25 km2in area were selected, and 28 of these lakes were used to evaluate detection errors. The minimum composite NDVI showed a better detection performance on lake water pixels than did the official MODIS 16-day 250 m NDVI based on a maximum composite method. The overall lake area detection performance based on the 15-day minimum composite NDVI showed -2.5% error relative to the Landsat-derived lake area for the 28 evaluated lakes. The errors increased with increases in the perimeter-to-area ratio but decreased with lake size over 10 km2. The lake area decreased by -9.3% at an annual rate of -53.7 km2 yr-1 during 2000 to 2011 for the 73 lakes. However, considerable spatial variations, such as slight-to-moderate lake area reductions in semi-arid regions and rapid lake area reductions in arid regions, were also detected. This study demonstrated applicability of MODIS 250 m reflectance data for biweekly monitoring of lake area change and diagnosed considerable lake area reduction and its spatial variability in arid and semi-arid regions of Mongolia. Future studies are required for explaining reasons of lake area changes and their spatial variability. PMID:27007233

Assessing Seasonal and Inter-Annual Variations of Lake Surface Areas in Mongolia during 2000-2011 Using Minimum Composite MODIS NDVI.

PubMed

Kang, Sinkyu; Hong, Suk Young

2016-01-01

A minimum composite method was applied to produce a 15-day interval normalized difference vegetation index (NDVI) dataset from Moderate Resolution Imaging Spectroradiometer (MODIS) daily 250 m reflectance in the red and near-infrared bands. This dataset was applied to determine lake surface areas in Mongolia. A total of 73 lakes greater than 6.25 km2in area were selected, and 28 of these lakes were used to evaluate detection errors. The minimum composite NDVI showed a better detection performance on lake water pixels than did the official MODIS 16-day 250 m NDVI based on a maximum composite method. The overall lake area detection performance based on the 15-day minimum composite NDVI showed -2.5% error relative to the Landsat-derived lake area for the 28 evaluated lakes. The errors increased with increases in the perimeter-to-area ratio but decreased with lake size over 10 km(2). The lake area decreased by -9.3% at an annual rate of -53.7 km(2) yr(-1) during 2000 to 2011 for the 73 lakes. However, considerable spatial variations, such as slight-to-moderate lake area reductions in semi-arid regions and rapid lake area reductions in arid regions, were also detected. This study demonstrated applicability of MODIS 250 m reflectance data for biweekly monitoring of lake area change and diagnosed considerable lake area reduction and its spatial variability in arid and semi-arid regions of Mongolia. Future studies are required for explaining reasons of lake area changes and their spatial variability.

Associations between sociodemographic and clinicopathological factors, and breast cancer subtypes in a population-based study

PubMed Central

Llanos, Adana A.M.; Chandwani, Sheenu; Bandera, Elisa V.; Hirshfield, Kim M.; Lin, Yong; Ambrosone, Christine B.; Demissie, Kitaw

2015-01-01

Purpose This study examines the factors distinguishing breast cancer (BC) subtypes. Methods We examined subtypes in 629 women with invasive BC, diagnosed from 2006–2012 and enrolled in an epidemiological study in New Jersey. Using molecular characteristics from pathology reports, BCs were categorized as luminal A, luminal B, non-luminal HER2-expressing, or triple-negative breast cancer [TNBC] subtypes. Multinomial logistic models (luminal A as referent) were used to describe BC subtype associations. Results Women with luminal B tumors were more likely to be younger at diagnosis (Odds ratio [OR] 1.8, 95% confidence interval [CI] 1.0–3.4) and to have higher grade (OR 2.6, 95% CI 1.5–4.7), larger (OR 1.9, 95% CI 1.0–3.6), and Ki67 positive tumors (OR 2.1, 95% CI 1.1–4.0). Women with non-luminal HER2-expressing BCs were more likely to have higher grade tumors (OR 14.5, 95% CI 5.3–39.7). Women with TNBCs were more likely to be African American (OR 1.9, 95% CI 1.0–3.4) and to have higher grade (Or 9.7, 95% CI 5.1–18.4), larger (OR 2.2, 95% CI 1.0–4.8), and Ki67 positive (OR 2.9, 95% CI 1.6–5.2) tumors. Notably, compared to the luminal A subtype, luminal B, non-luminal HER2-expressing and triple-negative subtypes were more frequently self-detected; however, these associations were attenuated in multivariable models. Conclusions These findings suggest that some BC subtypes were associated with features denoting more aggressive phenotypes, namely higher grade, larger size, and Ki67 positivity, and possibly patient self-detection among some women. These findings highlight a need for enhanced screening, particularly among younger women, racial/ethnic minorities and lower socioeconomic subgroups. PMID:26376894

Breast Cancer Subtypes and Response to Docetaxel in Node-Positive Breast Cancer: Use of an Immunohistochemical Definition in the BCIRG 001 Trial

PubMed Central

Hugh, Judith; Hanson, John; Cheang, Maggie Chon U.; Nielsen, Torsten O.; Perou, Charles M.; Dumontet, Charles; Reed, John; Krajewska, Maryla; Treilleux, Isabelle; Rupin, Matthieu; Magherini, Emmanuelle; Mackey, John; Martin, Miguel; Vogel, Charles

2009-01-01

Purpose To investigate the prognostic and predictive significance of subtyping node-positive early breast cancer by immunohistochemistry in a clinical trial of a docetaxel-containing regimen. Methods Pathologic data from a central laboratory were available for 1,350 patients (91%) from the BCIRG 001 trial of docetaxel, doxorubicin, and cyclophosphamide (TAC) versus fluorouracil, doxorubicin, and cyclophosphamide (FAC) for operable node-positive breast cancer. Patients were classified by tumor characteristics as (1) triple negative (estrogen receptor [ER]–negative, progesterone receptor [PR]–negative, HER2/neu [HER2]–negative), (2) HER2 (HER2-positive, ER-negative, PR-negative), (3) luminal B (ER-positive and/or PR-positive and either HER2-positive and/or Ki67high), and (4) luminal A (ER-positive and/or PR-positive and not HER2-positive or Ki67high), and assessed for prognostic significance and response to adjuvant chemotherapy. Results Patients were subdivided into triple negative (14.5%), HER2 (8.5%), luminal B (61.1%), and luminal A (15.9%). Three-year disease-free survival (DFS) rates (P values with luminal B as referent) were 67% (P < .0001), 68% (P = .0008), 82% (referent luminal B), and 91% (P = .0027), respectively, with hazard ratios of 2.22, 2.12, and 0.46. Improved 3-year DFS with TAC was found in the luminal B group (P = .025) and a combined ER-positive/HER2-negative group treated with tamoxifen (P = .041), with a marginal trend in the triple negatives (P = .051) and HER2 (P = .068) subtypes. No DFS advantage was seen in the luminal A population. Conclusion A simple immunopanel can divide breast cancers into biologic subtypes with strong prognostic effects. TAC significantly complements endocrine therapy in patients with luminal B subtype and, in the absence of targeted therapy, is effective in the triple-negative population. PMID:19204205

Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage

PubMed Central

Demitrack, Elise S; Aihara, Eitaro; Kenny, Susan; Varro, Andrea; Montrose, Marshall H

2012-01-01

Background and aims The authors’ goal was to measure pH at the gastric surface (pHo) to understand how acid secretion affects the repair of microscopic injury to the gastric epithelium. Methods Microscopic gastric damage was induced by laser light, during confocal/two-photon imaging of pH-sensitive dyes (Cl-NERF, BCECF) that were superfused over the mucosal surface of the exposed gastric corpus of anaesthetised mice. The progression of repair was measured in parallel with pHo. Experimental conditions included varying pH of luminal superfusates, and using omeprazole (60 mg/kg ip) or famotidine (30 mg/kg ip) to inhibit acid secretion. Results Similar rates of epithelial repair and resting pHo values (~pH 4) were reported in the presence of luminal pH 3 or pH 5. Epithelial repair was unreliable at luminal pH 2 and pHo was lower (2.5±0.2, P <0.05 vs pH 3). Epithelial repair was slower at luminal pH 7 and pHo was higher (6.4±0.1, P<0.001). In all conditions, pHo increased adjacent to damage. At luminal pH 3 or pH 7, omeprazole reduced maximal damage size and accelerated epithelial repair, although only at pH 3 did omeprazole further increase surface pH above the level caused by imposed damage. At luminal pH 7, famotidine also reduced maximal damage size and accelerated epithelial repair. Neither famotidine nor omeprazole raised plasma gastrin levels during the time course of the experiments. Conclusions Epithelial repair in vivo is affected by luminal pH variation, but the beneficial effects of acutely blocking acid secretion extend beyond simply raising luminal and/or surface pH. PMID:21997560

Detection of the Light Organ Symbiont, Vibrio fischeri, in Hawaiian Seawater by Using lux Gene Probes †

PubMed Central

Lee, Kyu-Ho; Ruby, Edward G.

1992-01-01

Symbiotic bacteria that inhabit the light-emitting organ of the Hawaiian squid Euprymna scolopes are distinctive from typical Vibrio fischeri organisms in that they are not visibly luminous when grown in laboratory culture. Therefore, the abundance of these bacteria in seawater samples cannot be estimated simply by identifying them among luminous colonies that arise on nutrient agar plates. Instead, we have used luxR and polymerase chain reaction generated luxA gene probes to identify both luminous and non-visibly luminous V. fischeri colonies by DNA-DNA hybridization. The probes were specific, hybridizing at least 50 to 100 times more strongly to immobilized DNAs from V. fischeri strains than to those of pure cultures of other related species. Thus, even non-visibly luminous V. fischeri colonies could be identified among colonies obtained from natural seawater samples by their probe-positive reaction. Bacteria in seawater samples, obtained either within or distant from squid habitats, were collected on membrane filters and incubated until colonies appeared. The filters were then observed for visibly luminous V. fischeri colonies and hybridized with the lux gene probes to determine the number of total V. fischeri colonies (both luminous and non-visibly luminous). We detected no significant differences in the abundance of luminous V. fischeri CFU in any of the water samples observed (≤1 to 3 CFU/100 ml). However, probe-positive colonies of V. fischeri (up to 900 CFU/100 ml) were found only in seawater collected from within the natural habitats of the squids. A number of criteria were used to confirm that these probe-positive strains were indistinguishable from symbiotic V. fischeri. Therefore, the luxA and luxR gene probes were species specific and gave a reliable estimate of the number of culturable V. fischeri colonies in natural water samples. Images PMID:16348678

Detection of the Light Organ Symbiont, Vibrio fischeri, in Hawaiian Seawater by Using lux Gene Probes.

PubMed

Lee, K H; Ruby, E G

1992-03-01

Symbiotic bacteria that inhabit the light-emitting organ of the Hawaiian squid Euprymna scolopes are distinctive from typical Vibrio fischeri organisms in that they are not visibly luminous when grown in laboratory culture. Therefore, the abundance of these bacteria in seawater samples cannot be estimated simply by identifying them among luminous colonies that arise on nutrient agar plates. Instead, we have used luxR and polymerase chain reaction generated luxA gene probes to identify both luminous and non-visibly luminous V. fischeri colonies by DNA-DNA hybridization. The probes were specific, hybridizing at least 50 to 100 times more strongly to immobilized DNAs from V. fischeri strains than to those of pure cultures of other related species. Thus, even non-visibly luminous V. fischeri colonies could be identified among colonies obtained from natural seawater samples by their probe-positive reaction. Bacteria in seawater samples, obtained either within or distant from squid habitats, were collected on membrane filters and incubated until colonies appeared. The filters were then observed for visibly luminous V. fischeri colonies and hybridized with the lux gene probes to determine the number of total V. fischeri colonies (both luminous and non-visibly luminous). We detected no significant differences in the abundance of luminous V. fischeri CFU in any of the water samples observed (

Chemosensitivity and Endocrine Sensitivity in Clinical Luminal Breast Cancer Patients in the Prospective Neoadjuvant Breast Registry Symphony Trial (NBRST) Predicted by Molecular Subtyping.

PubMed

Whitworth, Pat; Beitsch, Peter; Mislowsky, Angela; Pellicane, James V; Nash, Charles; Murray, Mary; Lee, Laura A; Dul, Carrie L; Rotkis, Michael; Baron, Paul; Stork-Sloots, Lisette; de Snoo, Femke A; Beatty, Jennifer

2017-03-01

Hormone receptor-positive (HR+) tumors have heterogeneous biology and present a challenge for determining optimal treatment. In the Neoadjuvant Breast Registry Symphony Trial (NBRST) patients were classified according to MammaPrint/BluePrint subtyping to provide insight into the response to neoadjuvant endocrine therapy (NET) or neoadjuvant chemotherapy (NCT). The purpose of this predefined substudy was to compare MammaPrint/BluePrint with conventional 'clinical' immunohistochemistry/fluorescence in situ hybridization (IHC/FISH) subtyping in 'clinical luminal' [HR+/human epidermal growth factor receptor 2-negative (HER2-)] breast cancer patients to predict treatment sensitivity. NBRST IHC/FISH HR+/HER2- breast cancer patients (n = 474) were classified into four molecular subgroups by MammaPrint/BluePrint subtyping: Luminal A, Luminal B, HER2, and Basal type. Pathological complete response (pCR) rates were compared with conventional IHC/FISH subtype. The overall pCR rate for 'clinical luminal' patients to NCT was 11 %; however, 87 of these 474 patients were reclassified as Basal type by BluePrint, with a high pCR rate of 32 %. The MammaPrint index was highly associated with the likelihood of pCR (p < 0.001). Fifty-three patients with BluePrint Luminal tumors received NET with an aromatase inhibitor and 36 (68 %) had a clinical response. With BluePrint subtyping, 18 % of clinical 'luminal' patients are classified in a different subgroup, compared with conventional assessment, and these patients have a significantly higher response rate to NCT compared with BluePrint Luminal patients. MammaPrint/BluePrint subtyping can help allocate effective treatment to appropriate patients. In addition, accurate identification of subtype biology is important in the interpretation of neoadjuvant treatment response since lack of pCR in luminal patients does not portend the worse prognosis associated with residual disease in Basal and HER2 subtypes.

Differentiation Between Luminal-A and Luminal-B Breast Cancer Using Intravoxel Incoherent Motion and Dynamic Contrast-Enhanced Magnetic Resonance Imaging.

PubMed

Kawashima, Hiroko; Miyati, Tosiaki; Ohno, Naoki; Ohno, Masako; Inokuchi, Masafumi; Ikeda, Hiroko; Gabata, Toshifumi

2017-12-01

The study aimed to investigate whether intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) can differentiate luminal-B from luminal-A breast cancer MATERIALS AND METHODS: Biexponential analyses of IVIM and DCE MRI were performed using a 3.0-T MRI scanner, involving 134 patients with 137 pathologically confirmed luminal-type invasive breast cancers. Luminal-type breast cancer was categorized as luminal-B breast cancer (LBBC, Ki-67 ≧ 14%) or luminal-A breast cancer (LABC, Ki-67 < 14%). Quantitative parameters from IVIM (pure diffusion coefficient [D], perfusion-related diffusion coefficient [D*], and fraction [f]) and DCE MRI (initial percentage of enhancement and signal enhancement ratio [SER]) were calculated. The apparent diffusion coefficient (ADC) was also calculated using monoexponential fitting. We correlated these data with the Ki-67 status. The D and ADC values of LBBC were significantly lower than those of LABC (P = 0.028, P = 0.037). The SER of LBBC was significantly higher than that of LABC (P = 0.004). A univariate analysis showed that a significantly lower D (<0.847 x 10 -3 mm 2 /s), lower ADC (<0.960 × 10 -3 mm 2 /s), and higher SER (>1.071) values were associated with LBBC (all P values <0.01), compared to LABC. In a multivariate analysis, a higher SER (>1.071; odds ratio: 3.0099, 95% confidence interval: 1.4246-6.3593; P = 0.003) value and a lower D (<0.847 × 10 -3 mm 2 /s; odds ratio: 2.6878, 95% confidence interval: 1.0445-6.9162; P = 0.040) value were significantly associated with LBBC, compared to LABC. The SER derived from DCE MRI and the D derived from IVIM are associated independently with the Ki-67 status in patients with luminal-type breast cancer. Copyright © 2017 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

Prognostic Significance of Progesterone Receptor–Positive Tumor Cells Within Immunohistochemically Defined Luminal A Breast Cancer

PubMed Central

Prat, Aleix; Cheang, Maggie Chon U.; Martín, Miguel; Parker, Joel S.; Carrasco, Eva; Caballero, Rosalía; Tyldesley, Scott; Gelmon, Karen; Bernard, Philip S.; Nielsen, Torsten O.; Perou, Charles M.

2013-01-01

Purpose Current immunohistochemical (IHC)-based definitions of luminal A and B breast cancers are imperfect when compared with multigene expression-based assays. In this study, we sought to improve the IHC subtyping by examining the pathologic and gene expression characteristics of genomically defined luminal A and B subtypes. Patients and Methods Gene expression and pathologic features were collected from primary tumors across five independent cohorts: British Columbia Cancer Agency (BCCA) tamoxifen-treated only, Grupo Español de Investigación en Cáncer de Mama 9906 trial, BCCA no systemic treatment cohort, PAM50 microarray training data set, and a combined publicly available microarray data set. Optimal cutoffs of percentage of progesterone receptor (PR) –positive tumor cells to predict survival were derived and independently tested. Multivariable Cox models were used to test the prognostic significance. Results Clinicopathologic comparisons among luminal A and B subtypes consistently identified higher rates of PR positivity, human epidermal growth factor receptor 2 (HER2) negativity, and histologic grade 1 in luminal A tumors. Quantitative PR gene and protein expression were also found to be significantly higher in luminal A tumors. An empiric cutoff of more than 20% of PR-positive tumor cells was statistically chosen and proved significant for predicting survival differences within IHC-defined luminal A tumors independently of endocrine therapy administration. Finally, no additional prognostic value within hormonal receptor (HR) –positive/HER2-negative disease was observed with the use of the IHC4 score when intrinsic IHC-based subtypes were used that included the more than 20% PR-positive tumor cells and vice versa. Conclusion Semiquantitative IHC expression of PR adds prognostic value within the current IHC-based luminal A definition by improving the identification of good outcome breast cancers. The new proposed IHC-based definition of luminal A tumors is HR positive/HER2 negative/Ki-67 less than 14%, and PR more than 20%. PMID:23233704

ATP mediates flow-induced NO production in thick ascending limbs

PubMed Central

Hong, Nancy J.; Garvin, Jeffrey L.

2012-01-01

Mechanical stimulation caused by increasing flow induces nucleotide release from many cells. Luminal flow and extracellular ATP stimulate production of nitric oxide (NO) in thick ascending limbs. However, the factors that mediate flow-induced NO production are unknown. We hypothesized that luminal flow stimulates thick ascending limb NO production via ATP. We measured NO in isolated, perfused rat thick ascending limbs using the fluorescent dye DAF FM. The rate of increase in dye fluorescence reflects NO accumulation. Increasing luminal flow from 0 to 20 nl/min stimulated NO production from 17 ± 16 to 130 ± 37 arbitrary units (AU)/min (P < 0.02). Increasing flow from 0 to 20 nl/min raised ATP release from 4 ± 1 to 21 ± 6 AU/min (P < 0.04). Hexokinase (10 U/ml) plus glucose, which consumes ATP, completely prevented the measured increase in ATP. Luminal flow did not increase NO production in the presence of luminal and basolateral hexokinase (10 U/ml). When flow was increased with the ATPase apyrase in both luminal and basolateral solutions (5 U/ml), NO levels did not change significantly. The P2 receptor antagonist suramin (300 μmol/l) reduced flow-induced NO production by 83 ± 25% (P < 0.03) when added to both and basolateral sides. Luminal hexokinase decreased flow-induced NO production from 205.6 ± 85.6 to 36.6 ± 118.6 AU/min (P < 0.02). Basolateral hexokinase also reduced flow-induced NO production. The P2X receptor-selective antagonist NF023 (200 μmol/l) prevented flow-induced NO production when added to the basolateral side but not the luminal side. We conclude that ATP mediates flow-induced NO production in the thick ascending limb likely via activation of P2Y receptors in the luminal and P2X receptors in the basolateral membrane. PMID:22496412

TRPV4 activation mediates flow-induced nitric oxide production in the rat thick ascending limb

PubMed Central

Garvin, Jeffrey L.

2014-01-01

Nitric oxide (NO) regulates renal function. Luminal flow stimulates NO production in the thick ascending limb (TAL). Transient receptor potential vanilloid 4 (TRPV4) is a mechano-sensitive channel activated by luminal flow in different types of cells. We hypothesized that TRPV4 mediates flow-induced NO production in the rat TAL. We measured NO production in isolated, perfused rat TALs using the fluorescent dye DAF FM. Increasing luminal flow from 0 to 20 nl/min stimulated NO from 8 ± 3 to 45 ± 12 arbitrary units (AU)/min (n = 5; P < 0.05). The TRPV4 antagonists, ruthenium red (15 μmol/l) and RN 1734 (10 μmol/l), blocked flow-induced NO production. Also, luminal flow did not increase NO production in the absence of extracellular calcium. We also studied the effect of luminal flow on NO production in TALs transduced with a TRPV4shRNA. In nontransduced TALs luminal flow increased NO production by 47 ± 17 AU/min (P < 0.05; n = 5). Similar to nontransduced TALs, luminal flow increased NO production by 39 ± 11 AU/min (P < 0.03; n = 5) in TALs transduced with a control negative sequence-shRNA while in TRPV4shRNA-transduced TALs, luminal flow did not increase NO production (Δ10 ± 15 AU/min; n = 5). We then tested the effect of two different TRPV4 agonists on NO production in the absence of luminal flow. 4α-Phorbol 12,13-didecanoate (1 μmol/l) enhanced NO production by 60 ± 11 AU/min (P < 0.002; n = 7) and GSK1016790A (10 ηmol/l) increased NO production by 52 ± 15 AU/min (P < 0.03; n = 5). GSK1016790A (10 ηmol/l) did not stimulate NO production in TRPV4shRNA-transduced TALs. We conclude that activation of TRPV4 channels mediates flow-induced NO production in the rat TAL. PMID:24966090

Endogenous flow-induced superoxide stimulates Na/H exchange activity via PKC in thick ascending limbs

PubMed Central

Garvin, Jeffrey L.

2014-01-01

Luminal flow stimulates Na reabsorption along the nephron and activates protein kinase C (PKC) which enhances endogenous superoxide (O2−) production by thick ascending limbs (TALs). Exogenously-added O2− augments TAL Na reabsorption, a process also dependent on PKC. Luminal Na/H exchange (NHE) mediates NaHCO3 reabsorption. However, whether flow-stimulated, endogenously-produced O2− enhances luminal NHE activity and the signaling pathway involved are unclear. We hypothesized that flow-induced production of endogenous O2− stimulates luminal NHE activity via PKC in TALs. Intracellular pH recovery was measured as an indicator of NHE activity in isolated, perfused rat TALs. Increasing luminal flow from 5 to 20 nl/min enhanced total NHE activity from 0.104 ± 0.031 to 0.167 ± 0.036 pH U/min, 81%. The O2− scavenger tempol decreased total NHE activity by 0.066 ± 0.011 pH U/min at 20 nl/min but had no significant effect at 5 nl/min. With the NHE inhibitor EIPA in the bath to block basolateral NHE, tempol reduced flow-enhanced luminal NHE activity by 0.029 ± 0.010 pH U/min, 30%. When experiments were repeated with staurosporine, a nonselective PKC inhibitor, tempol had no effect. Because PKC could mediate both induction of O2− by flow and the effect of O2− on luminal NHE activity, we used hypoxanthine/xanthine oxidase to elevate O2−. Hypoxanthine/xanthine oxidase increased luminal NHE activity by 0.099 ± 0.020 pH U/min, 137%. Staurosporine and the PKCα/β1-specific inhibitor Gö6976 blunted this effect. We conclude that flow-induced O2− stimulates luminal NHE activity in TALs via PKCα/β1. This accounts for part of flow-stimulated bicarbonate reabsorption by TALs. PMID:25080525

Optimization of self-study room open problem based on green and low-carbon campus construction

NASA Astrophysics Data System (ADS)

Liu, Baoyou

2017-04-01

The optimization of self-study room open arrangement problem in colleges and universities is conducive to accelerate the fine management of the campus and promote green and low-carbon campus construction. Firstly, combined with the actual survey data, the self-study area and living area were divided into different blocks, and the electricity consumption in each self-study room and distance between different living and studying areas were normalized. Secondly, the minimum of total satisfaction index and the minimum of the total electricity consumption were selected as the optimization targets respectively. The mathematical models of linear programming were established and resolved by LINGO software. The results showed that the minimum of total satisfaction index was 4055.533 and the total minimum electricity consumption was 137216 W. Finally, some advice had been put forward on how to realize the high efficient administration of the study room.

The evaluation of alternate methodologies for land cover classification in an urbanizing area

NASA Technical Reports Server (NTRS)

Smekofski, R. M.

1981-01-01

The usefulness of LANDSAT in classifying land cover and in identifying and classifying land use change was investigated using an urbanizing area as the study area. The question of what was the best technique for classification was the primary focus of the study. The many computer-assisted techniques available to analyze LANDSAT data were evaluated. Techniques of statistical training (polygons from CRT, unsupervised clustering, polygons from digitizer and binary masks) were tested with minimum distance to the mean, maximum likelihood and canonical analysis with minimum distance to the mean classifiers. The twelve output images were compared to photointerpreted samples, ground verified samples and a current land use data base. Results indicate that for a reconnaissance inventory, the unsupervised training with canonical analysis-minimum distance classifier is the most efficient. If more detailed ground truth and ground verification is available, the polygons from the digitizer training with the canonical analysis minimum distance is more accurate.

A Multi-Purpose, Detector-Based Photometric Calibration System for Luminous Intensity, Illuminance and Luminance

NASA Astrophysics Data System (ADS)

Lam, Brenda H. S.; Yang, Steven S. L.; Chau, Y. C.

2018-02-01

A multi-purpose detector based calibration system for luminous intensity, illuminance and luminance has been developed at the Government of the Hong Kong Special Administrative Region, Standards and Calibration Laboratory (SCL). In this paper, the measurement system and methods are described. The measurement models and contributory uncertainties were validated using the Guide to the Expression of Uncertainty in Measurement (GUM) framework and Supplement 1 to the GUM - Propagation of distributions using a Monte Carlo method in accordance with the JCGM 100:2008 and JCGM 101:2008 at the intended precision level.

Optical coherence tomography investigations of ceramic lumineers

NASA Astrophysics Data System (ADS)

Fernandes, Luana O.; Graça, Natalia D. R. L.; Melo, Luciana S. A.; Silva, Claudio H. V.; Gomes, Anderson S. L.

2016-02-01

Lumineers are veneer laminates used as an alternative for aesthetic dental solutions of the highest quality, but the only current means of its performance assessment is visual inspection. The objective of this study was to use the Optical Coherence Tomography (OCT) technique working in spectral domain to analyze in vivo in a single patient, 14 lumineers 180 days after cementation. It was possible to observe images in various kinds of changes in the cementing line and the laminate. It was concluded that the OCT is an effective and promising method to clinical evaluation of the cementing line in lumineers.

Assessment of uterine luminal pH in mares and the effect of dilute vinegar lavage on uterine luminal pH and endometrial health.

PubMed

Thompson, Renee L; Gunn, Allan J; Stephen, Cyril P; Ip, Heather; Brookes, Victoria J

2018-05-19

Uterine luminal pH has been demonstrated to be a valid indicator of uterine health in species such as cattle and sheep. However, research regarding uterine luminal pH in equines is lacking. The objectives of this study were to assess uterine luminal pH in mares during the estrous cycle, and evaluate the effect of dilute vinegar lavage on both uterine luminal pH and endometrial health. The study was conducted using a randomized block design in which eight mares (four Thoroughbred and four Standardbred) were aged matched then randomly assigned to two groups. Endometrial biopsies were taken from each mare prior to trial commencement. The treatment group (n = 4; 1 Thoroughbred, 3 Standardbreds) received a uterine lavage of one liter dilute vinegar (20 mL of vinegar in 1 L saline) every second day during each estrus period throughout the trial. Control group mares did not receive a uterine lavage. Uterine luminal pH measurements were recorded in all mares in both groups for a period of up to 10 min immediately prior to lavage (0 h), one hour and 24 h post lavage (same time points in control group mares as if they had been treated). Diestrus uterine luminal pH measurements were recorded once between days 6-10 post-ovulation. Endometrial biopsies were repeated from all mares at trial completion. Mean uterine luminal pH ranged from pH 5.3 to 7.6 and was significantly lower during diestrus compared to estrus (P < 0.001). Regression analysis indicated that this variation in pH was best explained by estrous cycle day, with uterine luminal pH increasing by a mean of 0.03 units each day (P < 0.001) from 6 to 10 days post-ovulation through to ovulation. Uterine lavage with dilute vinegar did not significantly affect uterine luminal pH (P > 0.05). A scoring system to quantify the abundance of cell types in the endometrial biopsies showed that mares in the treatment group had a significant decrease in polymorphonuclear cell abundance between pre- and post-trial biopsies (P = 0.03). Mares in the treatment group also had a significant decrease in lymphocyte, plasma cell and eosinophil cell abundance (P = 0.05). Although dilute vinegar lavage was not associated with a significant change in uterine luminal pH, it was associated with a significant improvement in endometrial biopsy scores. Because the control group did not receive a uterine lavage, further research is required to determine if this significant improvement results from the addition of dilute vinegar, or the uterine lavage itself. Copyright © 2018 Elsevier Inc. All rights reserved.

Simultaneous chromatic and luminance human electroretinogram responses

PubMed Central

Parry, Neil R A; Murray, Ian J; Panorgias, Athanasios; McKeefry, Declan J; Lee, Barry B; Kremers, Jan

2012-01-01

The parallel processing of information forms an important organisational principle of the primate visual system. Here we describe experiments which use a novel chromatic–achromatic temporal compound stimulus to simultaneously identify colour and luminance specific signals in the human electroretinogram (ERG). Luminance and chromatic components are separated in the stimulus; the luminance modulation has twice the temporal frequency of the chromatic modulation. ERGs were recorded from four trichromatic and two dichromatic subjects (1 deuteranope and 1 protanope). At isoluminance, the fundamental (first harmonic) response was elicited by the chromatic component in the stimulus. The trichromatic ERGs possessed low-pass temporal tuning characteristics, reflecting the activity of parvocellular post-receptoral mechanisms. There was very little first harmonic response in the dichromats’ ERGs. The second harmonic response was elicited by the luminance modulation in the compound stimulus and showed, in all subjects, band-pass temporal tuning characteristic of magnocellular activity. Thus it is possible to concurrently elicit ERG responses from the human retina which reflect processing in both chromatic and luminance pathways. As well as providing a clear demonstration of the parallel nature of chromatic and luminance processing in the human retina, the differences that exist between ERGs from trichromatic and dichromatic subjects point to the existence of interactions between afferent post-receptoral pathways that are in operation from the earliest stages of visual processing. PMID:22586211

Nanofiber Nerve Guide for Peripheral Nerve Repair and Regeneration

DTIC Science & Technology

2016-04-01

faster regeneration and functional recovery. Peripheral nerve injury is a common complication of complex tissue trauma and often results in significant...having poor regeneration overall, the areas of regenerating nerve tissue could often be found in sections of the nerve guide where luminal spaces of...conducted in this Aim also provided important insight into the NGC design parameters necessary to allow for maximum nerve tissue ingrowth and regeneration

Imaging and mapping the impact of clouds on skyglow with all-sky photometry.

PubMed

Jechow, Andreas; Kolláth, Zoltán; Ribas, Salvador J; Spoelstra, Henk; Hölker, Franz; Kyba, Christopher C M

2017-07-27

Artificial skyglow is constantly growing on a global scale, with potential ecological consequences ranging up to affecting biodiversity. To understand these consequences, worldwide mapping of skyglow for all weather conditions is urgently required. In particular, the amplification of skyglow by clouds needs to be studied, as clouds can extend the reach of skyglow into remote areas not affected by light pollution on clear nights. Here we use commercial digital single lens reflex cameras with fisheye lenses for all-sky photometry. We track the reach of skyglow from a peri-urban into a remote area on a clear and a partly cloudy night by performing transects from the Spanish town of Balaguer towards Montsec Astronomical Park. From one single all-sky image, we extract zenith luminance, horizontal and scalar illuminance. While zenith luminance reaches near-natural levels at 5 km distance from the town on the clear night, similar levels are only reached at 27 km on the partly cloudy night. Our results show the dramatic increase of the reach of skyglow even for moderate cloud coverage at this site. The powerful and easy-to-use method promises to be widely applicable for studies of ecological light pollution on a global scale also by non-specialists in photometry.

Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: a 3-dimensional cardiac computed tomography imaging study in Japanese subjects.

PubMed

Dagvasumberel, Munkhbaatar; Shimabukuro, Michio; Nishiuchi, Takeshi; Ueno, Junji; Takao, Shoichiro; Fukuda, Daiju; Hirata, Yoichiro; Kurobe, Hirotsugu; Soeki, Takeshi; Iwase, Takashi; Kusunose, Kenya; Niki, Toshiyuki; Yamaguchi, Koji; Taketani, Yoshio; Yagi, Shusuke; Tomita, Noriko; Yamada, Hirotsugu; Wakatsuki, Tetsuzo; Harada, Masafumi; Kitagawa, Tetsuya; Sata, Masataka

2012-09-10

Growing evidence suggests that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). In this study, we explored gender disparities in EAT volume (EATV) and its impact on coronary atherosclerosis. The study population consisted of 90 consecutive subjects (age: 63 ± 12 years; men: 47, women: 43) who underwent 256-slice multi-detector computed tomography (MDCT) coronary angiography. EATV was measured as the sum of cross-sectional epicardial fat area on CT images, from the lower surface of the left pulmonary artery origin to the apex. Subjects were segregated into the CAD group (coronary luminal narrowing > 50%) and non-CAD group. EATV/body surface area (BSA) was higher among men in the CAD group than in the non-CAD group (62 ± 13 vs. 33 ± 10 cm3/m2, p < 0.0001), but did not differ significantly among women in the 2 groups (49 ± 18 vs. 42 ± 9 cm3/m2, not significant). Multivariate logistic analysis showed that EATV/BSA was the single predictor for >50% coronary luminal narrowing in men (p < 0.0001). Predictors excluded were age, body mass index, hypertension, diabetes mellitus, and hyperlipidemia. Increased EATV is strongly associated with coronary atherosclerosis in men.

The Effect of Illumination on Gray Color

ERIC Educational Resources Information Center

Da Pos, Osvaldo; Baratella, Linda; Sperandio, Gabriele

2010-01-01

The present study explored the perceptual process of integration of luminance information in the production of the gray color of an object placed in an environment viewed from a window. The mean luminance of the object was varied for each mean luminance of the environment. Participants matched the gray color of the object with that of Munsell…

10 CFR 31.12 - General license for certain items and self-luminous products containing radium-226.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false General license for certain items and self-luminous... LICENSES FOR BYPRODUCT MATERIAL § 31.12 General license for certain items and self-luminous products..., or transfer, in accordance with the provisions of paragraphs (b), (c), and (d) of this section...

10 CFR 31.12 - General license for certain items and self-luminous products containing radium-226.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false General license for certain items and self-luminous... LICENSES FOR BYPRODUCT MATERIAL § 31.12 General license for certain items and self-luminous products..., or transfer, in accordance with the provisions of paragraphs (b), (c), and (d) of this section...

Separate first- and second-order processing is supported by spatial summation estimates at the fovea and eccentrically.

PubMed

Sukumar, Subash; Waugh, Sarah J

2007-03-01

We estimated spatial summation areas for the detection of luminance-modulated (LM) and contrast-modulated (CM) blobs at the fovea, 2.5, 5 and 10 deg eccentrically. Gaussian profiles were added or multiplied to binary white noise to create LM and CM blob stimuli and these were used to psychophysically estimate detection thresholds and spatial summation areas. The results reveal significantly larger summation areas for detecting CM than LM blobs across eccentricity. These differences are comparable to receptive field size estimates made in V1 and V2. They support the notion that separate spatial processing occurs for the detection of LM and CM stimuli.

Relationship Between Endothelial Wall Shear Stress and High-Risk Atherosclerotic Plaque Characteristics for Identification of Coronary Lesions That Cause Ischemia: A Direct Comparison With Fractional Flow Reserve.

PubMed

Han, Donghee; Starikov, Anna; Ó Hartaigh, Bríain; Gransar, Heidi; Kolli, Kranthi K; Lee, Ji Hyun; Rizvi, Asim; Baskaran, Lohendran; Schulman-Marcus, Joshua; Lin, Fay Y; Min, James K

2016-12-19

Wall shear stress (WSS) is an established predictor of coronary atherosclerosis progression. Prior studies have reported that high WSS has been associated with high-risk atherosclerotic plaque characteristics (APCs). WSS and APCs are quantifiable by coronary computed tomography angiography, but the relationship of coronary lesion ischemia-evaluated by fractional flow reserve-to WSS and APCs has not been examined. WSS measures were obtained from 100 evaluable patients who underwent coronary computed tomography angiography and invasive coronary angiography with fractional flow reserve. Patients were categorized according to tertiles of mean WSS values defined as low, intermediate, and high. Coronary ischemia was defined as fractional flow reserve ≤0.80. Stenosis severity was determined by minimal luminal diameter. APCs were defined as positive remodeling, low attenuation plaque, and spotty calcification. The likelihood of having positive remodeling and low-attenuation plaque was greater in the high WSS group compared with the low WSS group after adjusting for minimal luminal diameter (odds ratio for positive remodeling: 2.54, 95% CI 1.12-5.77; odds ratio for low-attenuation plaque: 2.68, 95% CI 1.02-7.06; both P<0.05). No significant relationship was observed between WSS and fractional flow reserve when adjusting for either minimal luminal diameter or APCs. WSS displayed no incremental benefit above stenosis severity and APCs for detecting lesions that caused ischemia (area under the curve for stenosis and APCs: 0.87, 95% CI 0.81-0.93; area under the curve for stenosis, APCs, and WSS: 0.88, 95% CI 0.82-0.93; P=0.30 for difference). High WSS is associated with APCs independent of stenosis severity. WSS provided no added value beyond stenosis severity and APCs for detecting lesions with significant ischemia. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

A stent for co-delivering paclitaxel and nitric oxide from abluminal and luminal surfaces: Preparation, surface characterization, and in vitro drug release studies

NASA Astrophysics Data System (ADS)

Gallo, Annemarie; Mani, Gopinath

2013-08-01

Most drug-eluting stents currently available are coated with anti-proliferative drugs on both abluminal (toward blood vessel wall) and luminal (toward lumen) surfaces to prevent neointimal hyperplasia. While the abluminal delivery of anti-proliferative drugs is useful for controlling neointimal hyperplasia, the luminal delivery of such drugs impairs or prevents endothelialization which causes late stent thrombosis. This research is focused on developing a bidirectional dual drug-eluting stent to co-deliver an anti-proliferative agent (paclitaxel - PAT) and an endothelial cell promoting agent (nitric oxide - NO) from abluminal and luminal surfaces of the stent, respectively. Phosphonoacetic acid, a polymer-free drug delivery platform, was initially coated on the stents. Then, the PAT and NO donor drugs were co-coated on the abluminal and luminal stent surfaces, respectively. The co-coating of drugs was collectively confirmed by the surface characterization techniques such as Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), 3D optical surface profilometry, and contact angle goniometry. SEM showed that the integrity of the co-coating of drugs was maintained without delamination or cracks formation occurring during the stent expansion experiments. In vitro drug release studies showed that the PAT was released from the abluminal stent surfaces in a biphasic manner, which is an initial burst followed by a slow and sustained release. The NO was burst released from the luminal stent surfaces. Thus, this study demonstrated the co-delivery of PAT and NO from abluminal and luminal stent surfaces, respectively. The stent developed in this study has potential applications in inhibiting neointimal hyperplasia as well as encouraging luminal endothelialization to prevent late stent thrombosis.

Impact of physiological hormonal fluctuations on 18F-fluorodeoxyglucose uptake in breast cancer.

PubMed

Miyake, Kanae K; Nakamoto, Yuji; Saji, Shigehira; Sugie, Tomoharu; Kurihara, Kensuke; Kanao, Shotaro; Ikeda, Debra M; Toi, Masakazu; Togashi, Kaori

2018-06-01

Premenopausal physiologic steroid levels change cyclically, in contrast to steady state low levels seen in postmenopausal patients. The purpose of this study was to evaluate whether 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake in breast cancer is influenced by physiological hormonal fluctuations. A total of 160 primary invasive breast cancers from 155 females (54 premenopausal, 101 postmenopausal) who underwent 18 F-FDG positron emission tomography/computed tomography before therapy were retrospectively analyzed. The maximal standardized uptake values (SUVmax) of tumors were compared with menstrual phases and menopausal status according to the following subgroups: 'luminal A-like,' 'luminal B-like,' and 'non-luminal.' Additionally, the effect of estradiol (E2) on 18 F-FDG uptake in breast cancer cells was evaluated in vitro. Among premenopausal patients, SUVmax during the periovulatory-luteal phase was significantly higher than that during the follicular phase in luminal A-like tumors (n = 25, p = 0.004), while it did not differ between the follicular phase and the periovulatory-luteal phase in luminal B-like (n = 24) and non-luminal tumors (n = 7). Multiple regression analysis showed menstrual phase, tumor size, and Ki-67 index are independent predictors for SUVmax in premenopausal luminal A-like tumors. There were no significant differences in SUVmax between pre- and postmenopausal patients in any of the subgroups. In in vitro studies, uptake in estrogen receptor-positive cells was significantly augmented when E2 concentration was increased from 0.01 to ≥ 1 nM. Our data suggest that 18 F-FDG uptake may be impacted by physiological hormonal fluctuations during menstrual cycle in luminal A-like cancers, and that E2 could be partly responsible for these events.

The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations.

PubMed

Christensen, Henriette L; Păunescu, Teodor G; Matchkov, Vladimir; Barbuskaite, Dagne; Brown, Dennis; Damkier, Helle H; Praetorius, Jeppe

2017-01-01

The cerebrospinal fluid (CSF) pH influences brain interstitial pH and, therefore, brain function. We hypothesized that the choroid plexus epithelium (CPE) expresses the vacuolar H + -ATPase (V-ATPase) as an acid extrusion mechanism in the luminal membrane to counteract detrimental elevations in CSF pH. The expression of mRNA corresponding to several V-ATPase subunits was demonstrated by RT-PCR analysis of CPE cells (CPECs) isolated by fluorescence-activated cell sorting. Immunofluorescence and electron microscopy localized the V-ATPase primarily in intracellular vesicles with only a minor fraction in the luminal microvillus area. The vesicles did not translocate to the luminal membrane in two in vivo models of hypocapnia-induced alkalosis. The Na + -independent intracellular pH (pH i ) recovery from acidification was studied in freshly isolated clusters of CPECs. At extracellular pH (pH o ) 7.4, the cells failed to display significant concanamycin A-sensitive pH i recovery (i.e., V-ATPase activity). The recovery rate in the absence of Na + amounted to <10% of the pH i recovery rate observed in the presence of Na + Recovery of pH i was faster at pH o 7.8 and was abolished at pH o 7.0. The concanamycin A-sensitive pH i recovery was stimulated by cAMP at pH 7.4 in vitro, but intraventricular infusion of the membrane-permeant cAMP analog 8-CPT-cAMP did not result in trafficking of the V-ATPase. In conclusion, we find evidence for the expression of a minor fraction of V-ATPase in the luminal membrane of CPECs. This fraction does not contribute to enhanced acid extrusion at high extracellular pH, but seems to be activated by cAMP in a trafficking-independent manner. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

Measuring high-resolution sky luminance distributions with a CCD camera.

PubMed

Tohsing, Korntip; Schrempf, Michael; Riechelmann, Stefan; Schilke, Holger; Seckmeyer, Gunther

2013-03-10

We describe how sky luminance can be derived from a newly developed hemispherical sky imager (HSI) system. The system contains a commercial compact charge coupled device (CCD) camera equipped with a fish-eye lens. The projection of the camera system has been found to be nearly equidistant. The luminance from the high dynamic range images has been calculated and then validated with luminance data measured by a CCD array spectroradiometer. The deviation between both datasets is less than 10% for cloudless and completely overcast skies, and differs by no more than 20% for all sky conditions. The global illuminance derived from the HSI pictures deviates by less than 5% and 20% under cloudless and cloudy skies for solar zenith angles less than 80°, respectively. This system is therefore capable of measuring sky luminance with the high spatial and temporal resolution of more than a million pixels and every 20 s respectively.

Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque through luminal blood

NASA Astrophysics Data System (ADS)

Yeager, Doug; Karpiouk, Andrei; Wang, Bo; Amirian, James; Sokolov, Konstantin; Smalling, Richard; Emelianov, Stanislav

2012-10-01

Combined intravascular ultrasound and intravascular photoacoustic (IVUS/IVPA) imaging has been previously established as a viable means for assessing atherosclerotic plaque morphological and compositional characteristics using both endogenous and exogenous contrast. In this study, IVUS/IVPA imaging of atherosclerotic rabbit aortas following systemic injection of gold nanorods (AUNRs) with peak absorbance within the tissue optical window is performed. Ex vivo imaging results reveal a high photoacoustic signal from localized AUNRs in regions with atherosclerotic plaques. Corresponding histological staining further confirms the preferential extravasation of AUNRs in atherosclerotic regions with compromised luminal endothelium and acute inflammation. The ability to detect AUNRs using combined IVUS and photoacoustic imaging in the presence of luminal saline and luminal blood is evaluated using both spectroscopic and single wavelength IVPA imaging techniques. Results demonstrate that AUNR detection within the arterial wall can be achieved using both methods, even in the case of imaging through luminal blood.

Effects of color combination and ambient illumination on visual perception time with TFT-LCD.

PubMed

Lin, Chin-Chiuan; Huang, Kuo-Chen

2009-10-01

An empirical study was carried out to examine the effects of color combination and ambient illumination on visual perception time using TFT-LCD. The effect of color combination was broken down into two subfactors, luminance contrast ratio and chromaticity contrast. Analysis indicated that the luminance contrast ratio and ambient illumination had significant, though small effects on visual perception. Visual perception time was better at high luminance contrast ratio than at low luminance contrast ratio. Visual perception time under normal ambient illumination was better than at other ambient illumination levels, although the stimulus color had a confounding effect on visual perception time. In general, visual perception time was better for the primary colors than the middle-point colors. Based on the results, normal ambient illumination level and high luminance contrast ratio seemed to be the optimal choice for design of workplace with video display terminals TFT-LCD.

[Effect of organic and inorganic toxic compounds on luminescence of luminous fungi].

PubMed

Vydriakova, G A; Gusev, A A; Medvedeva, S E

2011-01-01

The possibility of the development of the solid phase bioluminescent biotest using aerial mycelium of the luminous fungi was investigated. Effect of organic and inorganic toxic compounds (TC) at concentrations from 10(-6) to 1 mg/ml on luminescence of aerial mycelia of four species of luminous fungi-Armillaria borealis (Culture Collection of the Institute of Forest, Siberian Branch, Russian Academy of Sciences), A. mellea, A. gallica, and Lampteromyces japonicus (Fungi Collection of the Botanical Institute, Russian Academy of Sciences)--has been studied. Culture of A. mellea was shown to be most sensitive to solutions of the model TC. It was demonstrated that the sensitivity of the luminous fungi is comparable with the sensitivity of the bacteria that are used for environmental monitoring. Use of the aerial mycelium of the luminous fungi on the solid support as a test object is a promising approach in biotesting for the development of continuous biosensors for air monitoring.

ASASSN-15lh: A highly super-luminous supernova

NASA Astrophysics Data System (ADS)

Dong, Subo; Shappee, B. J.; Prieto, J. L.; Jha, S. W.; Stanek, K. Z.; Holoien, T. W.-S.; Kochanek, C. S.; Thompson, T. A.; Morrell, N.; Thompson, I. B.; Basu, U.; Beacom, J. F.; Bersier, D.; Brimacombe, J.; Brown, J. S.; Bufano, F.; Chen, Ping; Conseil, E.; Danilet, A. B.; Falco, E.; Grupe, D.; Kiyota, S.; Masi, G.; Nicholls, B.; Olivares E., F.; Pignata, G.; Pojmanski, G.; Simonian, G. V.; Szczygiel, D. M.; Woźniak, P. R.

2016-01-01

We report the discovery of ASASSN-15lh (SN 2015L), which we interpret as the most luminous supernova yet found. At redshift z = 0.2326, ASASSN-15lh reached an absolute magnitude of Mu,AB = -23.5 ± 0.1 and bolometric luminosity Lbol = (2.2 ± 0.2) × 1045 ergs s-1, which is more than twice as luminous as any previously known supernova. It has several major features characteristic of the hydrogen-poor super-luminous supernovae (SLSNe-I), whose energy sources and progenitors are currently poorly understood. In contrast to most previously known SLSNe-I that reside in star-forming dwarf galaxies, ASASSN-15lh appears to be hosted by a luminous galaxy (MK ≈ -25.5) with little star formation. In the 4 months since first detection, ASASSN-15lh radiated (1.1 ± 0.2) × 1052 ergs, challenging the magnetar model for its engine.

Feature-Selective Attentional Modulations in Human Frontoparietal Cortex.

PubMed

Ester, Edward F; Sutterer, David W; Serences, John T; Awh, Edward

2016-08-03

Control over visual selection has long been framed in terms of a dichotomy between "source" and "site," where top-down feedback signals originating in frontoparietal cortical areas modulate or bias sensory processing in posterior visual areas. This distinction is motivated in part by observations that frontoparietal cortical areas encode task-level variables (e.g., what stimulus is currently relevant or what motor outputs are appropriate), while posterior sensory areas encode continuous or analog feature representations. Here, we present evidence that challenges this distinction. We used fMRI, a roving searchlight analysis, and an inverted encoding model to examine representations of an elementary feature property (orientation) across the entire human cortical sheet while participants attended either the orientation or luminance of a peripheral grating. Orientation-selective representations were present in a multitude of visual, parietal, and prefrontal cortical areas, including portions of the medial occipital cortex, the lateral parietal cortex, and the superior precentral sulcus (thought to contain the human homolog of the macaque frontal eye fields). Additionally, representations in many-but not all-of these regions were stronger when participants were instructed to attend orientation relative to luminance. Collectively, these findings challenge models that posit a strict segregation between sources and sites of attentional control on the basis of representational properties by demonstrating that simple feature values are encoded by cortical regions throughout the visual processing hierarchy, and that representations in many of these areas are modulated by attention. Influential models of visual attention posit a distinction between top-down control and bottom-up sensory processing networks. These models are motivated in part by demonstrations showing that frontoparietal cortical areas associated with top-down control represent abstract or categorical stimulus information, while visual areas encode parametric feature information. Here, we show that multivariate activity in human visual, parietal, and frontal cortical areas encode representations of a simple feature property (orientation). Moreover, representations in several (though not all) of these areas were modulated by feature-based attention in a similar fashion. These results provide an important challenge to models that posit dissociable top-down control and sensory processing networks on the basis of representational properties. Copyright © 2016 the authors 0270-6474/16/368188-12$15.00/0.

Linear-regression convolutional neural network for fully automated coronary lumen segmentation in intravascular optical coherence tomography.

PubMed

Yong, Yan Ling; Tan, Li Kuo; McLaughlin, Robert A; Chee, Kok Han; Liew, Yih Miin

2017-12-01

Intravascular optical coherence tomography (OCT) is an optical imaging modality commonly used in the assessment of coronary artery diseases during percutaneous coronary intervention. Manual segmentation to assess luminal stenosis from OCT pullback scans is challenging and time consuming. We propose a linear-regression convolutional neural network to automatically perform vessel lumen segmentation, parameterized in terms of radial distances from the catheter centroid in polar space. Benchmarked against gold-standard manual segmentation, our proposed algorithm achieves average locational accuracy of the vessel wall of 22 microns, and 0.985 and 0.970 in Dice coefficient and Jaccard similarity index, respectively. The average absolute error of luminal area estimation is 1.38%. The processing rate is 40.6 ms per image, suggesting the potential to be incorporated into a clinical workflow and to provide quantitative assessment of vessel lumen in an intraoperative time frame. (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

High-z X-ray Obscured Quasars in Galaxies with Extreme Mid-IR/Optical Colors

NASA Astrophysics Data System (ADS)

Piconcelli, E.; Lanzuisi, G.; Fiore, F.; Feruglio, C.; Vignali, C.; Salvato, M.; Grappioni, C.

2009-05-01

Extreme Optical/Mid-IR color cuts have been used to uncover a population of dust-enshrouded, mid-IR luminous galaxies at high redshifts. Several lines of evidence point towards the presence of an heavily absorbed, possibly Compton-thick quasar at the heart of these systems. Nonetheless, the X-ray spectral properties of these intriguing sources still remain largely unexplored. Here we present an X-ray spectroscopic study of a large sample of 44 extreme dust-obscured galaxies (EDOGs) with F24 μm/FR>2000 and F24 μm>1.3 mJy selected from a 6 deg2 region in the SWIRE fields. The application of our selection criteria to a wide area survey has been capable of unveiling a population of X-ray luminous, absorbed z>1 quasars which is mostly missed in the traditional optical/X-ray surveys performed so far. Advances in the understanding of the X-ray properties of these recently-discovered sources by Simbol-X observations will be also discussed.

The Development of Luminance- and Texture-Defined Form Perception during the School-Aged Years

ERIC Educational Resources Information Center

Bertone, Armando; Hanck, Julie; Guy, Jacalyn; Cornish, Kim

2010-01-01

The objective of the present study was to assess the development of luminance- and texture-defined static form perception in school-aged children. This was done using an adapted Landolt-C technique where C-optotypes were defined by either luminance or texture information, the latter necessitating extra-striate neural processing to be perceived.…

Meal-stimulated release of methionine-enkephalin into the canine jejunal lumen.

PubMed Central

Money, S R; Petroianu, A; Gintzler, A R; Jaffe, B M

1988-01-01

Application of enkephalins to the luminal surface of the bowel augments intestinal absorption. However, to date, endogenous enkephalins have not been demonstrated within intestinal luminal fluid. To determine whether enkephalins are present in the intestinal lumen, five adult dogs had 25-cm chronic jejunal Thiry-Vella loops constructed. Dogs were studied in the awake, fasted state. Jejunal loops were perfused with isoosmotic, neutral Krebs buffer containing protease inhibitors. After basal sampling, the dogs received a high fat meat meal. Collections were made during the meal and for 60 min postprandially. Luminal met-enkephalin levels were determined by radioimmunoassay and confirmed by HPLC. HPLC separation of luminal samples demonstrated two immunoreactive peaks which co-eluted with pure met-enkephalin and met-enkephalin-sulfoxide. Basal met-enkephalin outputs averaged 52 +/- 13 ng/min. The meal significantly increased mean luminal met-enkephalin output to 137 +/- 71 ng/min. During the initial 20-min postprandial period, output remained elevated (180 +/- 73 ng/min), after which it returned to basal levels. We conclude that met-enkephalin is present in the jejunal lumen, and that luminal release of this opioid is augmented by a meal. Images PMID:3343342

Association of proteasomal activity with metastasis in luminal breast cancer

NASA Astrophysics Data System (ADS)

Shashova, E. E.; Fesik, E. A.; Doroshenko, A. V.

2017-09-01

Chimotrypsin-like (ChTL) and caspase-like (CL) proteasomal activities were investigated in different variants of the tumor progression of luminal breast cancer. Patients with primary luminal breast cancer (n = 123) in stage T1-3N0-2M0 who had not received neoadjuvant treatment were included in this study. Proteasome ChTL and CL activities were determined in the samples of tumor and adjacent tissues. The coefficients of chymotrypsin-like (kChTL) and caspase-like (kCL) proteasome activity were also calculated as the ratio of the corresponding activity in the tumor tissue to activity in the adjacent tissue. ChTL, CL, kChTL and kCL in the tissues of luminal A and B breast cancer with lymphogenic metastasis were compared, and their association with hematogenous metastasis was evaluated. On the one hand, CL activity of proteasomes increased in luminal A breast cancer with extensive lymphogenic metastasis (N2), on the other hand it decreased in the luminal B subtype of cancer. The ratio of proteasomal activity in the tumor and adjacent tissues plays a significant role in the hematogenic pathway of breast cancer progression and is associated with poor metastatic-free survival.

Very Long O-antigen Chains Enhance Fitness during Salmonella-induced Colitis by Increasing Bile Resistance

PubMed Central

Crawford, Robert W.; Keestra, A. Marijke; Winter, Sebastian E.; Xavier, Mariana N.; Tsolis, Renée M.; Tolstikov, Vladimir; Bäumler, Andreas J.

2012-01-01

Intestinal inflammation changes the luminal habitat for microbes through mechanisms that have not been fully resolved. We noticed that the FepE regulator of very long O-antigen chain assembly in the enteric pathogen Salmonella enterica serotype Typhimurium (S. Typhimurium) conferred a luminal fitness advantage in the mouse colitis model. However, a fepE mutant was not defective for survival in tissue, resistance to complement or resistance to polymyxin B. We performed metabolite profiling to identify changes in the luminal habitat that accompany S. Typhimurium-induced colitis. This analysis suggested that S. Typhimurium-induced colitis increased the luminal concentrations of total bile acids. A mutation in fepE significantly reduced the minimal inhibitory concentration (MIC) of S. Typhimurium for bile acids in vitro. Oral administration of the bile acid sequestrant cholestyramine resin lowered the concentrations of total bile acids in colon contents during S. Typhimurium infection and significantly reduced the luminal fitness advantage conferred by the fepE gene in the mouse colitis model. Collectively, these data suggested that very long O-antigen chains function in bile acid resistance of S. Typhimurium, a property conferring a fitness advantage during luminal growth in the inflamed intestine. PMID:23028318

Symbiotic association of Photobacterium fischeri with the marine luminous fish Monocentris japonica; a model of symbiosis based on bacterial studies.

PubMed

Ruby, E G; Nealson, K H

1976-12-01

Isolation of bacteria from the luminous organ of the fish Monocentris japonica has revealed that the organ contains a pure culture of luminous bacteria. For the four fish examined, all contained Photobacterium fischeri as their luminous bacterial symbiont. This is the first time that P. fischeri has been identified in a symbiotic association. A representative isolate (MJl) of the light organ population was selected for in vivo studies of its luminous system. Several physiological features suggest adaptation for symbiotic existence. First, MJl has been shown to produce and respond to an inducer of luciferase that could accumulate in the light organ. Secondly, the specific activity of light production was seen to be maximal under low, growth-limiting concentrations of oxygen. Thirdly, unlike another luminous species (Beneckea harveyi), synthesis of the light production system of these bacteria is not catabolite repressed by glucose--a possible source of nutrition in the light organ. Fourthly, when grown aerobically on glucose these bacteria excrete pyruvic acid into the medium. This production of pyruvate is a major process, accounting for 30-40% of the glucose utilized and may serve as a form of regulatory and nutritional communication with the host.

Luminance gradient at object borders communicates object location to the human oculomotor system.

PubMed

Kilpeläinen, Markku; Georgeson, Mark A

2018-01-25

The locations of objects in our environment constitute arguably the most important piece of information our visual system must convey to facilitate successful visually guided behaviour. However, the relevant objects are usually not point-like and do not have one unique location attribute. Relatively little is known about how the visual system represents the location of such large objects as visual processing is, both on neural and perceptual level, highly edge dominated. In this study, human observers made saccades to the centres of luminance defined squares (width 4 deg), which appeared at random locations (8 deg eccentricity). The phase structure of the square was manipulated such that the points of maximum luminance gradient at the square's edges shifted from trial to trial. The average saccade endpoints of all subjects followed those shifts in remarkable quantitative agreement. Further experiments showed that the shifts were caused by the edge manipulations, not by changes in luminance structure near the centre of the square or outside the square. We conclude that the human visual system programs saccades to large luminance defined square objects based on edge locations derived from the points of maximum luminance gradients at the square's edges.

47 CFR 22.951 - Minimum coverage requirement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MOBILE SERVICES Cellular Radiotelephone Service § 22.951 Minimum coverage requirement. Applications for authority to operate a new cellular system in an unserved area, other than those filed by the licensee of an... toward the minimum coverage requirement. Applications for authority to operate a new cellular system in...

Detection of chromatic and luminance distortions in natural scenes.

PubMed

Jennings, Ben J; Wang, Karen; Menzies, Samantha; Kingdom, Frederick A A

2015-09-01

A number of studies have measured visual thresholds for detecting spatial distortions applied to images of natural scenes. In one study, Bex [J. Vis.10(2), 1 (2010)10.1167/10.2.231534-7362] measured sensitivity to sinusoidal spatial modulations of image scale. Here, we measure sensitivity to sinusoidal scale distortions applied to the chromatic, luminance, or both layers of natural scene images. We first established that sensitivity does not depend on whether the undistorted comparison image was of the same or of a different scene. Next, we found that, when the luminance but not chromatic layer was distorted, performance was the same regardless of whether the chromatic layer was present, absent, or phase-scrambled; in other words, the chromatic layer, in whatever form, did not affect sensitivity to the luminance layer distortion. However, when the chromatic layer was distorted, sensitivity was higher when the luminance layer was intact compared to when absent or phase-scrambled. These detection threshold results complement the appearance of periodic distortions of the image scale: when the luminance layer is distorted visibly, the scene appears distorted, but when the chromatic layer is distorted visibly, there is little apparent scene distortion. We conclude that (a) observers have a built-in sense of how a normal image of a natural scene should appear, and (b) the detection of distortion in, as well as the apparent distortion of, natural scene images is mediated predominantly by the luminance layer and not chromatic layer.

Near-field visual acuity of pigeons: effects of head location and stimulus luminance.

PubMed

Hodos, W; Leibowitz, R W; Bonbright, J C

1976-03-01

Two pigeons were trained to discriminate a grating stimulus from a blank stimulus of equivalent luminance in a three-key chamber. The stimuli and blanks were presented behind a transparent center key. The procedure was a conditional discrimination in which pecks on the left key were reinforced if the blank had been present behind the center key and pecks on the right key were reinforced if the grating had been present behind the center key. The spatial frequency of the stimuli was varied in each session from four to 29.5 lines per millimeter in accordance with a variation of the method of constant stimuli. The number of lines per millimeter that the subjects could discriminate at threshold was determined from psychometric functions. Data were collected at five values of stimulus luminance ranging from--0.07 to 3.29 log cd/m2. The distance from the stimulus to the anterior nodal point of the eye, which was determined from measurements taken from high-speed motion-picture photographs of three additional pigeons and published intraocular measurements, was 62.0 mm. This distance and the grating detection thresholds were used to calculate the visual acuity of the birds at each level of luminance. Acuity improved with increasing luminance to a peak value of 0.52, which corresponds to a visual angle of 1.92 min, at a luminance of 2.33 log cd/m2. Further increase in luminance produced a small decline in acuity.

Resolution acuity versus recognition acuity with Landolt-style optotypes.

PubMed

Heinrich, Sven P; Bach, Michael

2013-09-01

International standards define acuity as the reciprocal of the threshold gap size of a Landolt C optotype. However, the literature is inconsistent as to what type of acuity is measured with Landolt Cs. The present study addresses this question more directly than previous studies by quantifying the effect of an inherent luminance artifact in Landolt-style optotypes. Two groups of modified optotypes were used. In the first group, each optotype had a single gap structure with the same average luminance. Between optotypes, the gap structures differed in their degree of fineness. In the second group of optotypes, a standard gap was always present, defining the orientation of the optotype. Additional gap structures of the same average luminance, but different fineness, were inserted at the remaining potential gap locations, thereby balancing luminance across potential gap locations. Visual acuity measures were obtained for each optotype variant, using a computer-based test employing a staircase procedure. Similar acuity values were obtained for all optotypes of the first group, and for standard Landolt Cs, irrespective of the fineness of the gap structure. With luminance-balanced optotypes of the second group, measured acuity was halved, compared to standard optotypes. The results support the view that it is recognition acuity, rather than resolution acuity, which is measured with standard Landolt-style optotypes, with the imbalanced luminance distribution serving as a cue. Luminance-balanced optotypes may help to obtain a more veridical estimate of resolution acuity, although recognition acuity may be more relevant in daily living.

On the search for an appropriate metric for reaction time to suprathreshold increments and decrements.

PubMed

Vassilev, Angel; Murzac, Adrian; Zlatkova, Margarita B; Anderson, Roger S

2009-03-01

Weber contrast, DeltaL/L, is a widely used contrast metric for aperiodic stimuli. Zele, Cao & Pokorny [Zele, A. J., Cao, D., & Pokorny, J. (2007). Threshold units: A correct metric for reaction time? Vision Research, 47, 608-611] found that neither Weber contrast nor its transform to detection-threshold units equates human reaction times in response to luminance increments and decrements under selective rod stimulation. Here we show that their rod reaction times are equated when plotted against the spatial luminance ratio between the stimulus and its background (L(max)/L(min), the larger and smaller of background and stimulus luminances). Similarly, reaction times to parafoveal S-cone selective increments and decrements from our previous studies [Murzac, A. (2004). A comparative study of the temporal characteristics of processing of S-cone incremental and decremental signals. PhD thesis, New Bulgarian University, Sofia, Murzac, A., & Vassilev, A. (2004). Reaction time to S-cone increments and decrements. In: 7th European conference on visual perception, Budapest, August 22-26. Perception, 33, 180 (Abstract).], are better described by the spatial luminance ratio than by Weber contrast. We assume that the type of stimulus detection by temporal (successive) luminance discrimination, by spatial (simultaneous) luminance discrimination or by both [Sperling, G., & Sondhi, M. M. (1968). Model for visual luminance discrimination and flicker detection. Journal of the Optical Society of America, 58, 1133-1145.] determines the appropriateness of one or other contrast metric for reaction time.

Characteristics and generation of secondary jets and secondary gigantic jets

NASA Astrophysics Data System (ADS)

Lee, Li-Jou; Huang, Sung-Ming; Chou, Jung-Kung; Kuo, Cheng-Ling; Chen, Alfred B.; Su, Han-Tzong; Hsu, Rue-Rou; Frey, Harald U.; Takahashi, Yukihiro; Lee, Lou-Chuang

2012-06-01

Secondary transient luminous events (TLEs) recorded by the ISUAL-FORMOSAT2 mission can either be secondary jets or secondary gigantic jets (GJs), depending on their terminal altitudes. The secondary jets emerge from the cloud top beneath the preceding sprites and extend upward to the base of the sprites at ˜50 km. The secondary jets likely are negative electric discharges with vertically straight luminous columns, morphologically resembling the trailing jet of the type-I GJs. The number of luminous columns in a secondary jet seems to be affected by the size of the effective capacitor plate formed near the base of the preceding sprites and the charge distribution left behind by the sprite-inducing positive cloud-to-ground discharges. The secondary GJs originate from the cloud top under the shielding area of the preceding sprites, and develop upward to reach the lower ionosphere at ˜90 km. The observed morphology of the secondary GJs can either be the curvy shifted secondary GJs extending outside the region occupied by the preceding sprites or the straight pop-through secondary GJs developing through the center of the preceding circular sprites. A key factor in determining the terminal height of the secondary TLEs appears to be the local ionosphere boundary height that established by the preceding sprites. The abundance and the distribution of the negative charge in the thundercloud following the sprite-inducing positive cloud-to-ground discharges may play important role in the generation of the secondary TLEs.

Quantitative multi-modality imaging analysis of a bioabsorbable poly-L-lactic acid stent design in the acute phase: a comparison between 2- and 3D-QCA, QCU and QMSCT-CA.

PubMed

Bruining, Nico; Tanimoto, Shuzou; Otsuka, Masato; Weustink, Annick; Ligthart, Jurgen; de Winter, Sebastiaan; van Mieghem, Carlos; Nieman, Koen; de Feyter, Pim J; van Domburg, Ron T; Serruys, Patrick W

2008-08-01

To investigate if three-dimensional (3D) based quantitative techniques are comparable to each other and to explore possible differences with respect to the reference method of 2D-QCA in the acute phase and to study whether non-invasive MSCT could potentially be applied to quantify luminal dimensions of a stented coronary segment with a novel bioabsorable drug-eluting stent made of poly-l-lactic-acid (PLLA). Quantitative imaging data derived from 16 patients enrolled at our institution in a first-in-man trial (ABSORB) receiving a biodegradable stent and who were imaged with standard coronary angiography and intravascular ultrasound were compared. Shortly, after stenting the patients also underwent a MSCT procedure. Standard 2D-QCA showed significant smaller stent lengths (p < 0.01). Although, the absolute measured stent diameters and areas by 2D-QCA tend to be smaller, the differences failed to be statistically different when compared to the 3D based quantitative modalities. Measurements made by non-invasive QMSCT-CA of implanted PLLA stents appeared to be comparable to the other 3D modalities without significant differences. Three-dimensional based quantitative analyses showed similar results quantifying luminal dimensions as compared to 2D-QCA during an evaluation of a new bioabsorbable coronary stent design in the acute phase. Furthermore, in biodegradable stents made of PLLA, non-invasive QMSCT-CA can be used to quantify luminal dimensions.

A luminous gamma-ray binary in the large magellanic cloud

DOE PAGES

Corbet, R. H. D.; Chomiuk, L.; Coe, M. J.; ...

2016-09-27

Gamma-ray binaries consist of a neutron star or a black hole interacting with a normal star to produce gamma-ray emission that dominates the radiative output of the system. Previously, only a handful of such systems have been discovered, all within our Galaxy. We report the discovery of a luminous gamma-ray binary in the Large Magellanic Cloud, found with the Fermi Large Area Telescope (LAT), from a search for periodic modulation in all sources in the third Fermi LAT catalog. This is the first such system to be found outside the Milky Way. Furthermore, the system has an orbital period ofmore » 10.3 days, and is associated with a massive O5III star located in the supernova remnant DEM L241, previously identified as the candidate high-mass X-ray binary (HMXB) CXOU J053600.0–673507. X-ray and radio emission are also modulated on the 10.3 day period, but are in anti-phase with the gamma-ray modulation. Optical radial velocity measurements suggest that the system contains a neutron star. The source is significantly more luminous than similar sources in the Milky Way, at radio, optical, X-ray, and gamma-ray wavelengths. The detection of this extra-galactic system, but no new Galactic systems, raises the possibility that the predicted number of gamma-ray binaries in our Galaxy has been overestimated, and that HMXBs may be born containing relatively slowly rotating neutron stars.« less

Eta Carinae and Other Luminous Blue Variables

NASA Technical Reports Server (NTRS)

Corcoran, M. F.

2006-01-01

Luminous Blue Variables (LBVs) are believed to be evolved, extremely massive stars close to the Eddington Limit and hence prone to bouts of large-scale, unstable mass loss. I discuss current understanding of the evolutionary state of these objects, the role duplicity may play and known physical characteristics of these stars using the X-ray luminous LBVs Eta Carinae and HD 5980 as test cases.

Delimitation of homogeneous regions in the UNIFESP/EPM healthcare center coverage area based on sociodemographic indicators.

PubMed

Harada, K Y; Silva, J G; Schenkman, S; Hayama, E T; Santos, F R; Prado, M C; Pontes, R H

1999-01-07

The drawing up of adequate Public Health action planning to address the true needs of the population would increase the chances of effectiveness and decrease unnecessary expenses. To identify homogeneous regions in the UNIFESP/EPM healthcare center (HCC) coverage area based on sociodemographic indicators and to relate them to causes of deaths in 1995. Secondary data analysis. HCC coverage area; primary care. Sociodemographic indicators were obtained from special tabulations of the Demographic Census of 1991. Proportion of children and elderly in the population; family providers' education level (maximum: > 15 years, minimum: < 1 year) and income level (maximum: > 20 minimum wages, minimum: < 1 minimum wage); proportional mortality distribution The maximum income permitted the construction of four homogeneous regions, according to income ranking. Although the proportion of children and of elderly did not vary significantly among the regions, minimum income and education showed a statistically significant (p < 0.05) difference between the first region (least affluent) and the others. A clear trend of increasing maximum education was observed across the regions. Mortality also differed in the first region, with deaths generated by possibly preventable infections. The inequalities observed may contribute to primary health prevention.

Development and evaluation of a method of calibrating medical displays based on fixed adaptation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sund, Patrik, E-mail: patrik.sund@vgregion.se; Månsson, Lars Gunnar; Båth, Magnus

2015-04-15

Purpose: The purpose of this work was to develop and evaluate a new method for calibration of medical displays that includes the effect of fixed adaptation and by using equipment and luminance levels typical for a modern radiology department. Methods: Low contrast sinusoidal test patterns were derived at nine luminance levels from 2 to 600 cd/m{sup 2} and used in a two alternative forced choice observer study, where the adaptation level was fixed at the logarithmic average of 35 cd/m{sup 2}. The contrast sensitivity at each luminance level was derived by establishing a linear relationship between the ten pattern contrastmore » levels used at every luminance level and a detectability index (d′) calculated from the fraction of correct responses. A Gaussian function was fitted to the data and normalized to the adaptation level. The corresponding equation was used in a display calibration method that included the grayscale standard display function (GSDF) but compensated for fixed adaptation. In the evaluation study, the contrast of circular objects with a fixed pixel contrast was displayed using both calibration methods and was rated on a five-grade scale. Results were calculated using a visual grading characteristics method. Error estimations in both observer studies were derived using a bootstrap method. Results: The contrast sensitivities for the darkest and brightest patterns compared to the contrast sensitivity at the adaptation luminance were 37% and 56%, respectively. The obtained Gaussian fit corresponded well with similar studies. The evaluation study showed a higher degree of equally distributed contrast throughout the luminance range with the calibration method compensated for fixed adaptation than for the GSDF. The two lowest scores for the GSDF were obtained for the darkest and brightest patterns. These scores were significantly lower than the lowest score obtained for the compensated GSDF. For the GSDF, the scores for all luminance levels were statistically separated from the average value; three were lower and two were higher. For the compensated GSDF, three of the scores could not be separated from the average value. Conclusions: An observer study using clinically relevant displays and luminance settings has demonstrated that the calibration of displays according to the GSDF causes the perceived contrast to be unevenly distributed when using displays with a high luminance range. As the luminance range increases, the perceived contrast in the dark and bright regions will be significantly lower than the perceived contrast in the middle of the luminance range. A new calibration method that includes the effect of fixed adaptation was developed and evaluated in an observer study and was found to distribute the contrast of the display more evenly throughout the grayscale than the GSDF.« less

Evaluation of High Dynamic Range Photography as a Luminance Mapping Technique

DOE Office of Scientific and Technical Information (OSTI.GOV)

Inanici, Mehlika; Galvin, Jim

2004-12-30

The potential, limitations, and applicability of the High Dynamic Range (HDR) photography technique is evaluated as a luminance mapping tool. Multiple exposure photographs of static scenes are taken with a Nikon 5400 digital camera to capture the wide luminance variation within the scenes. The camera response function is computationally derived using the Photosphere software, and is used to fuse the multiple photographs into HDR images. The vignetting effect and point spread function of the camera and lens system is determined. Laboratory and field studies have shown that the pixel values in the HDR photographs can correspond to the physical quantitymore » of luminance with reasonable precision and repeatability.« less

Intraluminal laser speckle rheology using an omni-directional viewing catheter

PubMed Central

Wang, Jing; Hosoda, Masaki; Tshikudi, Diane M.; Hajjarian, Zeinab; Nadkarni, Seemantini K.

2016-01-01

A number of disease conditions in luminal organs are associated with alterations in tissue mechanical properties. Here, we report a new omni-directional viewing Laser Speckle Rheology (LSR) catheter for mapping the mechanical properties of luminal organs without the need for rotational motion. The LSR catheter incorporates multiple illumination fibers, an optical fiber bundle and a multi-faceted mirror to permit omni-directional viewing of the luminal wall. By retracting the catheter using a motor-drive assembly, cylindrical maps of tissue mechanical properties are reconstructed. Evaluation conducted in a test phantom with circumferentially-varying mechanical properties demonstrates the capability of the LSR catheter for the accurate mechanical assessment of luminal organs. PMID:28101407

Observations of Ultra-Luminous X-ray Sources, and Implications

NASA Astrophysics Data System (ADS)

Colbert, E. J. M.

2004-05-01

I will review observations of Ultra-Luminous X-ray Sources (ULXs; Lx > 1E39 erg/s), in particular those observations that have helped reveal the nature of these curious objects. Some recent observations suggest that ULXs are a heterogenous class. Although ULX phenomenology is not fully understood, I will present some examples from the (possibly overlapping) sub-classes. Since ULXs are the most luminous objects in starburst galaxies, they, and ``normal'' luminous black-hole high-mass X-ray binaries are intimately tied to the global galaxian X-ray-star-formation connection. Further work is needed to understand how ULXs form, and how they are associated with the putative population of intermediate-mass black holes.

Brightness perception of unrelated self-luminous colors.

PubMed

Withouck, Martijn; Smet, Kevin A G; Ryckaert, Wouter R; Pointer, Michael R; Deconinck, Geert; Koenderink, Jan; Hanselaer, Peter

2013-06-01

The perception of brightness of unrelated self-luminous colored stimuli of the same luminance has been investigated. The Helmholtz-Kohlrausch (H-K) effect, i.e., an increase in brightness perception due to an increase in saturation, is clearly observed. This brightness perception is compared with the calculated brightness according to six existing vision models, color appearance models, and models based on the concept of equivalent luminance. Although these models included the H-K effect and half of them were developed to work with unrelated colors, none of the models seemed to be able to fully predict the perceived brightness. A tentative solution to increase the prediction accuracy of the color appearance model CAM97u, developed by Hunt, is presented.

Trends in annual minimum exposed snow and ice cover in High Mountain Asia from MODIS

NASA Astrophysics Data System (ADS)

Rittger, Karl; Brodzik, Mary J.; Painter, Thomas H.; Racoviteanu, Adina; Armstrong, Richard; Dozier, Jeff

2016-04-01

Though a relatively short record on climatological scales, data from the Moderate Resolution Imaging Spectroradiometer (MODIS) from 2000-2014 can be used to evaluate changes in the cryosphere and provide a robust baseline for future observations from space. We use the MODIS Snow Covered Area and Grain size (MODSCAG) algorithm, based on spectral mixture analysis, to estimate daily fractional snow and ice cover and the MODICE Persistent Ice (MODICE) algorithm to estimate the annual minimum snow and ice fraction (fSCA) for each year from 2000 to 2014 in High Mountain Asia. We have found that MODSCAG performs better than other algorithms, such as the Normalized Difference Index (NDSI), at detecting snow. We use MODICE because it minimizes false positives (compared to maximum extents), for example, when bright soils or clouds are incorrectly classified as snow, a common problem with optical satellite snow mapping. We analyze changes in area using the annual MODICE maps of minimum snow and ice cover for over 15,000 individual glaciers as defined by the Randolph Glacier Inventory (RGI) Version 5, focusing on the Amu Darya, Syr Darya, Upper Indus, Ganges, and Brahmaputra River basins. For each glacier with an area of at least 1 km2 as defined by RGI, we sum the total minimum snow and ice covered area for each year from 2000 to 2014 and estimate the trends in area loss or gain. We find the largest loss in annual minimum snow and ice extent for 2000-2014 in the Brahmaputra and Ganges with 57% and 40%, respectively, of analyzed glaciers with significant losses (p-value<0.05). In the Upper Indus River basin, we see both gains and losses in minimum snow and ice extent, but more glaciers with losses than gains. Our analysis shows that a smaller proportion of glaciers in the Amu Darya and Syr Darya are experiencing significant changes in minimum snow and ice extent (3.5% and 12.2%), possibly because more of the glaciers in this region are smaller than 1 km2 than in the Indus, Ganges, and Brahmaputra making analysis from MODIS (pixel area ~0.25 km2) difficult. Overall, we see 23% of the glaciers in the 5 river basins with significant trends (in either direction). We relate these changes in area to topography and climate to understand the driving processes related to these changes. In addition to annual minimum snow and ice cover, the MODICE algorithm also provides the date of minimum fSCA for each pixel. To determine whether the surface was snow or ice we use the date of minimum fSCA from MODICE to index daily maps of snow on ice (SOI), or exposed glacier ice (EGI) and systematically derive an equilibrium line altitude (ELA) for each year from 2000-2014. We test this new algorithm in the Upper Indus basin and produce annual estimates of ELA. For the Upper Indus basin we are deriving annual ELAs that range from 5350 m to 5450 m which is slightly higher than published values of 5200 m for this region.

Astronomy. ASASSN-15lh: A highly super-luminous supernova.

PubMed

Dong, Subo; Shappee, B J; Prieto, J L; Jha, S W; Stanek, K Z; Holoien, T W-S; Kochanek, C S; Thompson, T A; Morrell, N; Thompson, I B; Basu, U; Beacom, J F; Bersier, D; Brimacombe, J; Brown, J S; Bufano, F; Chen, Ping; Conseil, E; Danilet, A B; Falco, E; Grupe, D; Kiyota, S; Masi, G; Nicholls, B; Olivares E, F; Pignata, G; Pojmanski, G; Simonian, G V; Szczygiel, D M; Woźniak, P R

2016-01-15

We report the discovery of ASASSN-15lh (SN 2015L), which we interpret as the most luminous supernova yet found. At redshift z = 0.2326, ASASSN-15lh reached an absolute magnitude of Mu ,AB = -23.5 ± 0.1 and bolometric luminosity Lbol = (2.2 ± 0.2) × 10(45) ergs s(-1), which is more than twice as luminous as any previously known supernova. It has several major features characteristic of the hydrogen-poor super-luminous supernovae (SLSNe-I), whose energy sources and progenitors are currently poorly understood. In contrast to most previously known SLSNe-I that reside in star-forming dwarf galaxies, ASASSN-15lh appears to be hosted by a luminous galaxy (MK ≈ -25.5) with little star formation. In the 4 months since first detection, ASASSN-15lh radiated (1.1 ± 0.2) × 10(52) ergs, challenging the magnetar model for its engine. Copyright © 2016, American Association for the Advancement of Science.

The effects of luminance contrast, colour combinations, font, and search time on brand icon legibility.

PubMed

Ko, Ya-Hsien

2017-11-01

This study explored and identified the effects of luminance contrast, colour combinations, font, and search time on brand icon legibility. A total of 108 participants took part in the experiment. As designed, legibility was measured as a function of the following independent variables: four levels of luminance contrast, sixteen target/background colour combinations, two fonts, and three search times. The results showed that a luminance contrast of 18:1 provided readers with the best legibility. Yellow on black, yellow on blue, and white on blue were the three most legible colour combinations. One of this study's unique findings was that colour combinations may play an even more important role than luminance contrast in the overall legibility of brand icon design. The 12-s search time corresponded with the highest legibility. Arial font was more legible than Times New Roman. These results provide some guidance for brand icon and product advertisement design. Copyright © 2017 Elsevier Ltd. All rights reserved.

Impact of Intestinal Microbiota on Intestinal Luminal Metabolome

PubMed Central

Matsumoto, Mitsuharu; Kibe, Ryoko; Ooga, Takushi; Aiba, Yuji; Kurihara, Shin; Sawaki, Emiko; Koga, Yasuhiro; Benno, Yoshimi

2012-01-01

Low–molecular-weight metabolites produced by intestinal microbiota play a direct role in health and disease. In this study, we analyzed the colonic luminal metabolome using capillary electrophoresis mass spectrometry with time-of-flight (CE-TOFMS) —a novel technique for analyzing and differentially displaying metabolic profiles— in order to clarify the metabolite profiles in the intestinal lumen. CE-TOFMS identified 179 metabolites from the colonic luminal metabolome and 48 metabolites were present in significantly higher concentrations and/or incidence in the germ-free (GF) mice than in the Ex-GF mice (p < 0.05), 77 metabolites were present in significantly lower concentrations and/or incidence in the GF mice than in the Ex-GF mice (p < 0.05), and 56 metabolites showed no differences in the concentration or incidence between GF and Ex-GF mice. These indicate that intestinal microbiota highly influenced the colonic luminal metabolome and a comprehensive understanding of intestinal luminal metabolome is critical for clarifying host-intestinal bacterial interactions. PMID:22724057

Mechanisms of intragastric pH sensing.

PubMed

Goo, Tyralee; Akiba, Yasutada; Kaunitz, Jonathan D

2010-12-01

Luminal amino acids and lack of luminal acidity as a result of acid neutralization by intragastric foodstuffs are powerful signals for acid secretion. Although the hormonal and neural pathways underlying this regulatory mechanism are well understood, the nature of the gastric luminal pH sensor has been enigmatic. In clinical studies, high pH, tryptic peptides, and luminal divalent metals (Ca(2+) and Mg(2+)) increase gastrin release and acid production. The calcium-sensing receptor (CaSR), first described in the parathyroid gland but expressed on gastric G cells, is a logical candidate for the gastric acid sensor. Because CaSR ligands include amino acids and divalent metals, and because extracellular pH affects ligand binding in the pH range of the gastric content, its pH, metal, and nutrient-sensing functions are consistent with physiologic observations. The CaSR is thus an attractive candidate for the gastric luminal sensor that is part of the neuroendocrine negative regulatory loop for acid secretion.

Visual evoked potential assessment of the effects of glaucoma on visual subsystems.

PubMed

Greenstein, V C; Seliger, S; Zemon, V; Ritch, R

1998-06-01

The purpose of this study is to test the hypothesis that glaucoma leads to selective deficits in parallel pathways or channels. Sweep VEPs were obtained to isolated-check stimuli that were modulated sinusoidally in either isoluminant chromatic contrast or in positive and negative luminance contrast. Response functions were obtained from 14 control subjects, 15 patients with open-angle glaucoma, and seven glaucoma suspects. For all three groups of subjects we found characteristic differences between the VEP response functions to isoluminant chromatic contrast stimuli and to luminance contrast stimuli. The isoluminant chromatic stimulus conditions appeared to favor activity of the P-pathway, whereas the luminance contrast stimuli at low depths of modulation favored M-pathway activity. VEP responses for patients with OAG were significantly reduced for chromatic contrast and luminance contrast conditions, whereas VEP responses for glaucoma suspects were significantly reduced only for the 15-Hz positive luminance contrast condition. Our results suggest that both M- and P-pathways are affected by glaucoma.

The skylight gradient of luminance helps sandhoppers in sun and moon identification.

PubMed

Ugolini, Alberto; Galanti, Giuditta; Mercatelli, Luca

2012-08-15

To return to the ecologically optimal zone of the beach, the sandhopper Talitrus saltator (Montagu) maintains a constant sea-land direction based on the sun and moon compasses. In this study, we investigated the role of the skylight gradient of luminance in sun and moon identification under natural and artificial conditions of illumination. Clock-shifted (inverted) sandhoppers tested under the sun (during their subjective night) and under the full moon (during their subjective day) exhibit orientation in accordance with correct identification of the sun and the moon at night. Tested in artificial conditions of illumination at night without the artificial gradient of luminance, the artificial astronomical cue is identified as the moon even when the conditions of illumination allow sun compass orientation during the day. When the artificial gradient of luminance is added, the artificial astronomical cue is identified as the sun. The role of the sky gradient of luminance in sun and moon identification is discussed on the basis of present and past findings.

Encoding of luminance and contrast by linear and nonlinear synapses in the retina.

PubMed

Odermatt, Benjamin; Nikolaev, Anton; Lagnado, Leon

2012-02-23

Understanding how neural circuits transmit information is technically challenging because the neural code is contained in the activity of large numbers of neurons and synapses. Here, we use genetically encoded reporters to image synaptic transmission across a population of sensory neurons-bipolar cells in the retina of live zebrafish. We demonstrate that the luminance sensitivities of these synapses varies over 10(4) with a log-normal distribution. About half the synapses made by ON and OFF cells alter their polarity of transmission as a function of luminance to generate a triphasic tuning curve with distinct maxima and minima. These nonlinear synapses signal temporal contrast with greater sensitivity than linear ones. Triphasic tuning curves increase the dynamic range over which bipolar cells signal light and improve the efficiency with which luminance information is transmitted. The most efficient synapses signaled luminance using just 1 synaptic vesicle per second per distinguishable gray level. Copyright © 2012 Elsevier Inc. All rights reserved.

The effects of luminance contribution from large fields to chromatic visual evoked potentials.

PubMed

Skiba, Rafal M; Duncan, Chad S; Crognale, Michael A

2014-02-01

Though useful from a clinical and practical standpoint uniform, large-field chromatic stimuli are likely to contain luminance contributions from retinal inhomogeneities. Such contribution can significantly influence psychophysical thresholds. However, the degree to which small luminance artifacts influence the chromatic VEP has been debated. In particular, claims have been made that band-pass tuning observed in chromatic VEPs result from luminance intrusion. However, there has been no direct evidence presented to support these claims. Recently, large-field isoluminant stimuli have been developed to control for intrusion from retinal inhomogeneities with particular regard to the influence of macular pigment. We report here the application of an improved version of these full-field stimuli to directly test the influence of luminance intrusion on the temporal tuning of the chromatic VEP. Our results show that band-pass tuning persists even when isoluminance is achieved throughout the extent of the stimulus. In addition, small amounts of luminance intrusion affect neither the shape of the temporal tuning function nor the major components of the VEP. These results support the conclusion that the chromatic VEP can depart substantially from threshold psychophysics with regard to temporal tuning and that obtaining a low-pass function is not requisite evidence of selective chromatic activation in the VEP. Copyright © 2013 Elsevier Ltd. All rights reserved.

Surface regions of illusory images are detected with a slower processing speed than those of luminance-defined images.

PubMed

Mihaylova, Milena; Manahilov, Velitchko

2010-11-24

Research has shown that the processing time for discriminating illusory contours is longer than for real contours. We know, however, little whether the visual processes, associated with detecting regions of illusory surfaces, are also slower as those responsible for detecting luminance-defined images. Using a speed-accuracy trade-off (SAT) procedure, we measured accuracy as a function of processing time for detecting illusory Kanizsa-type and luminance-defined squares embedded in 2D static luminance noise. The data revealed that the illusory images were detected at slower processing speed than the real images, while the points in time, when accuracy departed from chance, were not significantly different for both stimuli. The classification images for detecting illusory and real squares showed that observers employed similar detection strategies using surface regions of the real and illusory squares. The lack of significant differences between the x-intercepts of the SAT functions for illusory and luminance-modulated stimuli suggests that the detection of surface regions of both images could be based on activation of a single mechanism (the dorsal magnocellular visual pathway). The slower speed for detecting illusory images as compared to luminance-defined images could be attributed to slower processes of filling-in of regions of illusory images within the dorsal pathway.

Accurate method for luminous transmittance and signal detection quotients measurements in sunglasses lenses

NASA Astrophysics Data System (ADS)

Loureiro, A. D.; Gomes, L. M.; Ventura, L.

2018-02-01

The international standard ISO 12312-1 proposes transmittance tests that quantify how dark sunglasses lenses are and whether or not they are suitable for driving. To perform these tests a spectrometer is required. In this study, we present and analyze theoretically an accurate alternative method for performing these measurements using simple components. Using three LEDs and a four-channel sensor we generated weighting functions similar to the standard ones for luminous and traffic lights transmittances. From 89 sunglasses lens spectroscopy data, we calculated luminous transmittance and signal detection quotients using our obtained weighting functions and the standard ones. Mean-difference Tukey plots were used to compare the results. All tested sunglasses lenses were classified in the right category and correctly as suitable or not for driving. The greatest absolute errors for luminous transmittance and red, yellow, green and blue signal detection quotients were 0.15%, 0.17, 0.06, 0.04 and 0.18, respectively. This method will be used in a device capable to perform transmittance tests (visible, traffic lights and ultraviolet (UV)) according to the standard. It is important to measure rightly luminous transmittance and relative visual attenuation quotients to report correctly whether or not sunglasses are suitable for driving. Moreover, standard UV requirements depend on luminous transmittance.

Active matrix OLED for rugged HMD and viewfinder applications

NASA Astrophysics Data System (ADS)

Low, Kia; Jones, Susan K.; Prache, Olivier; Fellowes, David A.

2004-09-01

We present characterization of a full-color 852x3x600-pixel, active matrix organic light emitting diode (AMOLED) color microdisplay (eMagin Corporation's SVGA+ display) for environmentally demanding applications. The results show that the AMOLED microdisplay can provide cold-start turn-on and operate at extreme temperature conditions, far in excess of non-emissive displays. Correction factors for gamma response of the AMOLED microdisplay as a function of temperature have been determined to permit consistent luminance and contrast from -40°C to over +80°C. Gamma adjustments are made by a simple temperature compensation adjustment of the reference voltages of the AMOLED. The typical room temperature full-on luminance half-life of the SVGA+ full color display organic light emitting diode (OLED) display at over 3,000 hr at a starting luminance at approx. 100 cd/m2, translates to more than 15,000 hr of continuous full-motion video usage, based on a 25% duty cycle at a typical 50-60 cd/m2 commercial luminance level, or over 60,000 hr half-life in monochrome white usage, or over 100,000 hr luminance half-life in monochrome yellow usage at similar operating conditions. Half life at typical night vision luminance levels would be much longer.

Relationship of the luminous bacterial symbiont of the Caribbean flashlight fish, Kryptophanaron alfredi (family Anomalopidae) to other luminous bacteria based on bacterial luciferase (luxA) genes.

PubMed

Haygood, M G

1990-01-01

Flashlight fishes (family Anomalopidae) have light organs that contain luminous bacterial symbionts. Although the symbionts have not yet been successfully cultured, the luciferase genes have been cloned directly from the light organ of the Caribbean species, Kryptophanaron alfredi. The goal of this project was to evaluate the relationship of the symbiont to free-living luminous bacteria by comparison of genes coding for bacterial luciferase (lux genes). Hybridization of a lux AB probe from the Kryptophanaron alfredi symbiont to DNAs from 9 strains (8 species) of luminous bacteria showed that none of the strains tested had lux genes highly similar to the symbiont. The most similar were a group consisting of Vibrio harveyi, Vibrio splendidus and Vibrio orientalis. The nucleotide sequence of the luciferase alpha subunit gene luxA) of the Kryptophanaron alfredi symbiont was determined in order to do a more detailed comparison with published luxA sequences from Vibrio harveyi, Vibrio fischeri and Photobacterium leiognathi. The hybridization results, sequence comparisons and the mol% G + C of the Kryptophanaron alfredi symbiont luxA gene suggest that the symbiont may be considered as a new species of luminous Vibrio related to Vibrio harveyi.

An Exponential Luminous Efficiency Model for Hypervelocity Impact into Regolith

NASA Technical Reports Server (NTRS)

Swift, W. R.; Moser, D. E.; Suggs, R. M.; Cooke, W. J.

2011-01-01

The flash of thermal radiation produced as part of the impact-crater forming process can be used to determine the energy of the impact if the luminous efficiency is known. From this energy the mass and, ultimately, the mass flux of similar impactors can be deduced. The luminous efficiency, eta, is a unique function of velocity with an extremely large variation in the laboratory range of under 6 km/s but a necessarily small variation with velocity in the meteoric range of 20 to 70 km/s. Impacts into granular or powdery regolith, such as that on the moon, differ from impacts into solid materials in that the energy is deposited via a serial impact process which affects the rate of deposition of internal (thermal) energy. An exponential model of the process is developed which differs from the usual polynomial models of crater formation. The model is valid for the early time portion of the process and focuses on the deposition of internal energy into the regolith. The model is successfully compared with experimental luminous efficiency data from both laboratory impacts and from lunar impact observations. Further work is proposed to clarify the effects of mass and density upon the luminous efficiency scaling factors. Keywords hypervelocity impact impact flash luminous efficiency lunar impact meteoroid 1

Contribution of color signals to ocular following responses.

PubMed

Matsuura, Kiyoto; Kawano, Kenji; Inaba, Naoko; Miura, Kenichiro

2016-10-01

Ocular following responses (OFRs) are elicited at ultra-short latencies (< 60 ms) by sudden movements of the visual scene. In this study, we investigated the roles of color signals in OFRs in monkeys. To make physiologically isoluminant sinusoidal color gratings, we estimated the physiologically isoluminant points using OFRs and found that the physiologically isoluminant points were nearly independent of the spatiotemporal frequency of the gratings. We recorded OFRs induced by the motion of physiologically isoluminant color gratings and found that OFRs elicited by the motion of color gratings had different spatiotemporal frequency tuning from those elicited by the motion of luminance gratings. Additionally, OFRs to isoluminant color gratings had smaller peak responses, suggesting that color signals weakly contribute to OFRs compared with luminance signals. OFRs to the motion of stimuli composed of luminance and color signals were also examined. We found that color signals largely contributed to OFRs under low luminance signals regardless of whether color signals moved in the same or opposite direction to luminance signals. These results provide evidence of the multichannel visual computations underlying motor responses. We conclude that, in everyday situations, color information contributes cooperatively with luminance information to the generation of ocular tracking behaviors. © 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

Effect of ranibizumab on high-speed indocyanine green angiography and minimum intensity projection optical coherence tomography findings in neovascular age-related macular degeneration.

PubMed

Nicholson, Benjamin P; Nigam, Divya; Toy, Brian; Stetson, Paul F; Agrón, Elvira; Jacobs-El, Naima; Cunningham, Denise; Cukras, Catherine; Wong, Wai; Wiley, Henry; Chew, Emily; Ferris, Frederick; Meyerle, Catherine B

2015-01-01

The purpose of this 1-year prospective study was to investigate how induction/pro re nata ranibizumab intravitreal treatment of eyes with neovascular age-related macular degeneration affects the anatomy of choroidal neovascularization (CNV) and the overlying outer retinal tissue. High-speed indocyanine green (HS-ICG) angiography measurements provided quantification of the CNV size in 60 patients followed for 1 year. Minimum intensity projection optical coherence tomography (MinIP OCT), a novel algorithm assessing minimum optical intensity between the internal limiting membrane and retinal pigment epithelium, measured the area of outer retinal disruption overlying the CNV. Fluorescein angiography was also assessed to evaluate late retinal leakage. After 1 year, the mean area of CNV measured with indocyanine green angiography decreased by 5.8%. The mean area of MinIP OCT of outer retinal disruption overlying the CNV decreased by 4.2%. Mean area of fluorescein angiography leakage decreased by 6.3%. Both the area of outer retinal disruption measured with MinIP OCT and the area of leakage on fluorescein angiography typically exceeded the area of CNV on indocyanine green angiography at baseline and 1 year. Choroidal neovascularization treated with induction/pro re nata intravitreal ranibizumab for 1 year essentially remained static. Minimum intensity projection optical coherence tomography suggests that the area of outer retinal disruption overlying the CNV may be greater than the CNV itself and often correlates with the leakage area on fluorescein angiography. Additionally, there was minimal change in the area of outer retinal disruption on MinIP OCT even when fluid resolved. Measurements of the extent of CNV lesions based on indocyanine green angiography and MinIP OCT may provide useful outcome variables to help assess the CNV complex longitudinally and warrant further validation.

Connection method of separated luminal regions of intestine from CT volumes

NASA Astrophysics Data System (ADS)

Oda, Masahiro; Kitasaka, Takayuki; Furukawa, Kazuhiro; Watanabe, Osamu; Ando, Takafumi; Hirooka, Yoshiki; Goto, Hidemi; Mori, Kensaku

2015-03-01

This paper proposes a connection method of separated luminal regions of the intestine for Crohn's disease diagnosis. Crohn's disease is an inflammatory disease of the digestive tract. Capsule or conventional endoscopic diagnosis is performed for Crohn's disease diagnosis. However, parts of the intestines may not be observed in the endoscopic diagnosis if intestinal stenosis occurs. Endoscopes cannot pass through the stenosed parts. CT image-based diagnosis is developed as an alternative choice of the Crohn's disease. CT image-based diagnosis enables physicians to observe the entire intestines even if stenosed parts exist. CAD systems for Crohn's disease using CT volumes are recently developed. Such CAD systems need to reconstruct separated luminal regions of the intestines to analyze intestines. We propose a connection method of separated luminal regions of the intestines segmented from CT volumes. The luminal regions of the intestines are segmented from a CT volume. The centerlines of the luminal regions are calculated by using a thinning process. We enumerate all the possible sequences of the centerline segments. In this work, we newly introduce a condition using distance between connected ends points of the centerline segments. This condition eliminates unnatural connections of the centerline segments. Also, this condition reduces processing time. After generating a sequence list of the centerline segments, the correct sequence is obtained by using an evaluation function. We connect the luminal regions based on the correct sequence. Our experiments using four CT volumes showed that our method connected 6.5 out of 8.0 centerline segments per case. Processing times of the proposed method were reduced from the previous method.

Optimal combination of illusory and luminance-defined 3-D surfaces: A role for ambiguity.

PubMed

Hartle, Brittney; Wilcox, Laurie M; Murray, Richard F

2018-04-01

The shape of the illusory surface in stereoscopic Kanizsa figures is determined by the interpolation of depth from the luminance edges of adjacent inducing elements. Despite ambiguity in the position of illusory boundaries, observers reliably perceive a coherent three-dimensional (3-D) surface. However, this ambiguity may contribute additional uncertainty to the depth percept beyond what is expected from measurement noise alone. We evaluated the intrinsic ambiguity of illusory boundaries by using a cue-combination paradigm to measure the reliability of depth percepts elicited by stereoscopic illusory surfaces. We assessed the accuracy and precision of depth percepts using 3-D Kanizsa figures relative to luminance-defined surfaces. The location of the surface peak was defined by illusory boundaries, luminance-defined edges, or both. Accuracy and precision were assessed using a depth-discrimination paradigm. A maximum likelihood linear cue combination model was used to evaluate the relative contribution of illusory and luminance-defined signals to the perceived depth of the combined surface. Our analysis showed that the standard deviation of depth estimates was consistent with an optimal cue combination model, but the points of subjective equality indicated that observers consistently underweighted the contribution of illusory boundaries. This systematic underweighting may reflect a combination rule that attributes additional intrinsic ambiguity to the location of the illusory boundary. Although previous studies show that illusory and luminance-defined contours share many perceptual similarities, our model suggests that ambiguity plays a larger role in the perceptual representation of illusory contours than of luminance-defined contours.

Apoptosis-linked Gene-2 (ALG-2)/Sec31 Interactions Regulate Endoplasmic Reticulum (ER)-to-Golgi Transport

PubMed Central

Helm, Jared R.; Bentley, Marvin; Thorsen, Kevin D.; Wang, Ting; Foltz, Lauren; Oorschot, Viola; Klumperman, Judith; Hay, Jesse C.

2014-01-01

Luminal calcium released from secretory organelles has been suggested to play a regulatory role in vesicle transport at several steps in the secretory pathway; however, its functional roles and effector pathways have not been elucidated. Here we demonstrate for the first time that specific luminal calcium depletion leads to a significant decrease in endoplasmic reticulum (ER)-to-Golgi transport rates in intact cells. Ultrastructural analysis revealed that luminal calcium depletion is accompanied by increased accumulation of intermediate compartment proteins in COPII buds and clusters of unfused COPII vesicles at ER exit sites. Furthermore, we present several lines of evidence suggesting that luminal calcium affected transport at least in part through calcium-dependent interactions between apoptosis-linked gene-2 (ALG-2) and the Sec31A proline-rich region: 1) targeted disruption of ALG-2/Sec31A interactions caused severe defects in ER-to-Golgi transport in intact cells; 2) effects of luminal calcium and ALG-2/Sec31A interactions on transport mutually required each other; and 3) Sec31A function in transport required luminal calcium. Morphological phenotypes of disrupted ALG-2/Sec31A interactions were characterized. We found that ALG-2/Sec31A interactions were not required for the localization of Sec31A to ER exit sites per se but appeared to acutely regulate the stability and trafficking of the cargo receptor p24 and the distribution of the vesicle tether protein p115. These results represent the first outline of a mechanism that connects luminal calcium to specific protein interactions regulating vesicle trafficking machinery. PMID:25006245

The effect of luminous intensity on the attraction of phlebotomine sand flies to light traps.

PubMed

Lima-Neto, Abdias R; Costa-Neta, Benedita M; da Silva, Apoliana Araújo; Brito, Jefferson M; Aguiar, João V C; Ponte, Islana S; Silva, Francinaldo S

2018-05-04

To improve the efficiency of light traps in collecting phlebotomine sand flies, the potential effects of luminous intensity on the attraction of these insects to traps were evaluated. Sand flies were collected with Hooper Pugedo (HP) light traps fitted with 5-mm light-emitting diodes (LED) bulbs: green (520 nm wavelength-10,000, 15,000 and 20,000 millicandela (mcd) and blue (470 nm-4,000, 12,000 and 15,000 mcd). A total of 3,264 sand flies comprising 13 species were collected. The collected species were Lutzomyia longipalpis (Lutz & Neiva) (Diptera: Psychodidae) (52.48%), Evandromyia evandroi (Costa Lima & Antunes, 1939) (Diptera: Psychodidae) (32.90%) and Micropygomyia goiana (Martins, Falcão, & Silva) (Diptera: Psychodidae) (9.76%). An increase in luminous intensity of the LEDs increased the size of the sand fly catch. The lower luminous intensity of green (10,000 mcd) attracted an average of 13.7 ± 2.8 sand flies/trap per night and the other luminous intensities accounted for a mean of 24.1 ± 4.0 (15,000 mcd) and 28.2 ± 5.0 (20,000 mcd) sand flies/trap per night. Regarding the blue wavelength, the lower luminous intensity (4,000 mcd) attracted an average of 27.4 ± 4.1 sand flies/trap per night, followed by 12,000 mcd (37.6 ± 8.7) and 15,000 mcd (40.5 ± 7.3). Based on our data, the luminous intensity of light traps should be considered when developing light traps for monitoring or controlling phlebotomine sand flies.

30 CFR 77.805 - Cable couplers and connection boxes; minimum design requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Cable couplers and connection boxes; minimum... WORK AREAS OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.805 Cable couplers and connection boxes; minimum design requirements. (a)(1) Couplers that are used in medium- or high-voltage power...

30 CFR 77.805 - Cable couplers and connection boxes; minimum design requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Cable couplers and connection boxes; minimum... WORK AREAS OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.805 Cable couplers and connection boxes; minimum design requirements. (a)(1) Couplers that are used in medium- or high-voltage power...

30 CFR 77.805 - Cable couplers and connection boxes; minimum design requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Cable couplers and connection boxes; minimum... WORK AREAS OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.805 Cable couplers and connection boxes; minimum design requirements. (a)(1) Couplers that are used in medium- or high-voltage power...

Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study.

PubMed

O'Brien, Katie M; Cole, Stephen R; Tse, Chiu-Kit; Perou, Charles M; Carey, Lisa A; Foulkes, William D; Dressler, Lynn G; Geradts, Joseph; Millikan, Robert C

2010-12-15

Previous research identified differences in breast cancer-specific mortality across 4 intrinsic tumor subtypes: luminal A, luminal B, basal-like, and human epidermal growth factor receptor 2 positive/estrogen receptor negative (HER2(+)/ER(-)). We used immunohistochemical markers to subtype 1,149 invasive breast cancer patients (518 African American, 631 white) in the Carolina Breast Cancer Study, a population-based study of women diagnosed with breast cancer. Vital status was determined through 2006 using the National Death Index, with median follow-up of 9 years. Cancer subtypes luminal A, luminal B, basal-like, and HER2(+)/ER(-) were distributed as 64%, 11%, 11%, and 5% for whites, and 48%, 8%, 22%, and 7% for African Americans, respectively. Breast cancer mortality was higher for participants with HER2(+)/ER(-) and basal-like breast cancer compared with luminal A and B. African Americans had higher breast cancer-specific mortality than whites, but the effect of race was statistically significant only among women with luminal A breast cancer. However, when compared with the luminal A subtype within racial categories, mortality for participants with basal-like breast cancer was higher among whites (HR = 2.0, 95% CI: 1.2-3.4) than African Americans (HR = 1.5, 95% CI: 1.0-2.4), with the strongest effect seen in postmenopausal white women (HR = 3.9, 95% CI: 1.5-10.0). Our results confirm the association of basal-like breast cancer with poor prognosis and suggest that basal-like breast cancer is not an inherently more aggressive disease in African American women compared with whites. Additional analyses are needed in populations with known treatment profiles to understand the role of tumor subtypes and race in breast cancer mortality, and in particular our finding that among women with luminal A breast cancer, African Americans have higher mortality than whites. ©2010 AACR.

Glutamate 90 at the Luminal Ion Gate of Sarcoplasmic Reticulum Ca2+-ATPase Is Critical for Ca2+ Binding on Both Sides of the Membrane*

PubMed Central

Clausen, Johannes D.; Andersen, Jens Peter

2010-01-01

The roles of Ser72, Glu90, and Lys297 at the luminal ends of transmembrane helices M1, M2, and M4 of sarcoplasmic reticulum Ca2+-ATPase were examined by transient and steady-state kinetic analysis of mutants. The dependence on the luminal Ca2+ concentration of phosphorylation by Pi (“Ca2+ gradient-dependent E2P formation”) showed a reduction of the apparent affinity for luminal Ca2+ in mutants with alanine or leucine replacement of Glu90, whereas arginine replacement of Glu90 or Ser72 allowed E2P formation from Pi even at luminal Ca2+ concentrations much too small to support phosphorylation in wild type. The latter mutants further displayed a blocked dephosphorylation of E2P and an increased rate of conversion of the ADP-sensitive E1P phosphoenzyme intermediate to ADP-insensitive E2P as well as insensitivity of the E2·BeF3− complex to luminal Ca2+. Altogether, these findings, supported by structural modeling, indicate that the E2P intermediate is stabilized in the mutants with arginine replacement of Glu90 or Ser72, because the positive charge of the arginine side chain mimics Ca2+ occupying a luminally exposed low affinity Ca2+ site of E2P, thus identifying an essential locus (a “leaving site”) on the luminal Ca2+ exit pathway. Mutants with alanine or leucine replacement of Glu90 further displayed a marked slowing of the Ca2+ binding transition as well as slowing of the dissociation of Ca2+ from Ca2E1 back toward the cytoplasm, thus demonstrating that Glu90 is also critical for the function of the cytoplasmically exposed Ca2+ sites on the opposite side of the membrane relative to where Glu90 is located. PMID:20421308

An evaluation of Appalachian Trail hikers' knowledge of minimum impact skills and practices

Treesearch

Peter Newman; Robert Manning; Jim Bacon; Alan Graefe; Gerard Kyle

2002-01-01

As the number of visitors to national parks and related areas continues to rise and the types of visitors and activities continue to diversify, educating visitors in minimum skills can help to protect parks and related areas. Educating visitors in these skills can be a challenge, especially on the Appalachian Trail (AT) that travels through state, federal, municipal...

47 CFR 27.14 - Construction requirements; Criteria for renewal.

Code of Federal Regulations, 2013 CFR

2013-10-01

... at least 40 percent of the license area's population by March 13, 2017, and to at least 75 percent of... a license area by March 13, 2017, and 30 point-to-point links per million persons (one link per 33... minimum of 15 point-to-point links by March 13, 2017, and a minimum of 15 point-to-point links by...

Near-infrared properties of quasar and Seyfert host galaxies

NASA Astrophysics Data System (ADS)

McLeod, Kim Katris

1994-01-01

We present near-infrared images of nearly 100 host galaxies of Active Galactic Nuclei (AGN). Our quasar sample is comprised of the 50 quasars from the Palomar Green Bright Quasar Survey with redshifts z less than or equal to 0.3. We have restricted the redshift range to ensure adequate spatial resolution, galaxy detectability, and minimal distance-dependent effects, while still giving a large sample of objects. For lower-luminosity AGN we have chosen to image the CfA Seyfert sample. This sample is composed of 48 Seyferts, roughly equally divided among types 1, 1.5-1.9, and 2. This sample was spectroscopically selected, and, therefore, is not biased towards Seyferts with significant star formation. Taken together, these samples allow a statistical look at the continuity of host galaxy properties over a factor of 10,000 in nuclear luminosity. We find the near-infrared light to be a good tracer of luminous mass in these galaxies. The Seyferts are found in galaxies of type SO to Sc. The radio quiet quasars live in similar kinds of galaxies spanning the same range of mass centered around L(*). However, for the most luminous quasars, there is a correlation between the minimum host galaxy mass and the luminosity of the active nucleus. Radio-loud quasars are generally found in hosts more massive than an L(*) galaxy. We also detect a population of low mass host galaxies with very low luminosity Seyfert nuclei. The low luminosity quasars and the Seyferts both tend to lie in host galaxies seen preferentially face-on, which suggests there is a substantial amount of obscuration coplanar with the galaxian disk. The obscuration must be geometrically thick (thickness-to-radius approximately 1) and must cover a significant fraction of the narrow line region (r greater than 100 pc). We have examined our images for signs of perturbations that could drive fuel toward the galaxy nucleus, but there are none we can identify at a significant level. The critical element for fueling is evidently not reflected clearly in the large scale distribution of luminous mass in the galaxy. We also present an infrared image of the jet of SC 273 and compare it to optical and radio images from the literature.

Near-Infrared Properties of Quasar and Seyfert Host Galaxies

NASA Astrophysics Data System (ADS)

McLeod, Kim Katris

1995-01-01

We present near-infrared images of nearly 100 host galaxies of Active Galactic Nuclei (AGN). Our quasar sample is comprised of the 50 quasars from the Palomar Green Bright Quasar Survey with redshifts z\\<= 0.3. We have restricted the redshift range to ensure adequate spatial resolution, galaxy detectability, and minimal distance-dependent effects, while still giving a large sample of objects. For lower-luminosity AGN we have chosen to image the CfA Seyfert sample. This sample is composed of 48 Seyferts, roughly equally divided among types 1, 1.5-1.9, and 2. This sample was spectroscopically selected, and, therefore, is not biased towards Seyferts with significant star formation. Taken together, these samples allow a statistical look at the continuity of host-galaxy properties over a factor of 10,000 in nuclear luminosity. We find the near-infrared light to be a good tracer of luminous mass in these galaxies. The Seyferts are found in galaxies of type S0 to Sc. The radio quiet quasars live in similar kinds of galaxies spanning the same range of mass centered around L*. However, for the most luminous quasars, there is a correlation between the minimum host-galaxy mass and the luminosity of the active nucleus. Radio-loud quasars are generally found in hosts more massive than an L* galaxy. We also detect a population of low-mass host galaxies with very low-luminosity Seyfert nuclei. The low luminosity quasars and the Seyferts both tend to lie in host galaxies seen preferentially face-on, which suggests there is a substantial amount of obscuration coplanar with the galaxian disk. The obscuration must be geometrically thick (thickness-to-radius ~1) and must cover a significant fraction of the narrow line region (r>100 pc). We have examined our images for signs of perturbations that could drive fuel toward the galaxy nucleus, but there are none we can identify at a significant level. The critical element for fueling is evidently not reflected clearly in the large scale distribution of luminous mass in the galaxy. We also present an infrared image of the jet of 3C 273 and compare it to visible and radio images from the literature. (SECTION: Dissertation Summaries)

Linking express saccade occurance to stimulus properties and sensorimotor integration in the superior colliculus.

PubMed

Marino, Robert A; Levy, Ron; Munoz, Douglas P

2015-08-01

Express saccades represent the fastest possible eye movements to visual targets with reaction times that approach minimum sensory-motor conduction delays. Previous work in monkeys has identified two specific neural signals in the superior colliculus (SC: a midbrain sensorimotor integration structure involved in gaze control) that are required to execute express saccades: 1) previsual activity consisting of a low-frequency increase in action potentials in sensory-motor neurons immediately before the arrival of a visual response; and 2) a transient visual-sensory response consisting of a high-frequency burst of action potentials in visually responsive neurons resulting from the appearance of a visual target stimulus. To better understand how these two neural signals interact to produce express saccades, we manipulated the arrival time and magnitude of visual responses in the SC by altering target luminance and we examined the corresponding influences on SC activity and express saccade generation. We recorded from saccade neurons with visual-, motor-, and previsual-related activity in the SC of monkeys performing the gap saccade task while target luminance was systematically varied between 0.001 and 42.5 cd/m(2) against a black background (∼0.0001 cd/m(2)). Our results demonstrated that 1) express saccade latencies were linked directly to the arrival time in the SC of visual responses produced by abruptly appearing visual stimuli; 2) express saccades were generated toward both dim and bright targets whenever sufficient previsual activity was present; and 3) target luminance altered the likelihood of producing an express saccade. When an express saccade was generated, visuomotor neurons increased their activity immediately before the arrival of the visual response in the SC and saccade initiation. Furthermore, the visual and motor responses of visuomotor neurons merged into a single burst of action potentials, while the visual response of visual-only neurons was unaffected. A linear combination model was used to test which SC signals best predicted the likelihood of producing an express saccade. In addition to visual response magnitude and previsual activity of saccade neurons, the model identified presaccadic activity (activity occurring during the 30-ms epoch immediately before saccade initiation) as a third important signal for predicting express saccades. We conclude that express saccades can be predicted by visual, previsual, and presaccadic signals recorded from visuomotor neurons in the intermediate layers of the SC. Copyright © 2015 the American Physiological Society.

Linking express saccade occurance to stimulus properties and sensorimotor integration in the superior colliculus

PubMed Central

Levy, Ron; Munoz, Douglas P.

2015-01-01

Express saccades represent the fastest possible eye movements to visual targets with reaction times that approach minimum sensory-motor conduction delays. Previous work in monkeys has identified two specific neural signals in the superior colliculus (SC: a midbrain sensorimotor integration structure involved in gaze control) that are required to execute express saccades: 1) previsual activity consisting of a low-frequency increase in action potentials in sensory-motor neurons immediately before the arrival of a visual response; and 2) a transient visual-sensory response consisting of a high-frequency burst of action potentials in visually responsive neurons resulting from the appearance of a visual target stimulus. To better understand how these two neural signals interact to produce express saccades, we manipulated the arrival time and magnitude of visual responses in the SC by altering target luminance and we examined the corresponding influences on SC activity and express saccade generation. We recorded from saccade neurons with visual-, motor-, and previsual-related activity in the SC of monkeys performing the gap saccade task while target luminance was systematically varied between 0.001 and 42.5 cd/m2 against a black background (∼0.0001 cd/m2). Our results demonstrated that 1) express saccade latencies were linked directly to the arrival time in the SC of visual responses produced by abruptly appearing visual stimuli; 2) express saccades were generated toward both dim and bright targets whenever sufficient previsual activity was present; and 3) target luminance altered the likelihood of producing an express saccade. When an express saccade was generated, visuomotor neurons increased their activity immediately before the arrival of the visual response in the SC and saccade initiation. Furthermore, the visual and motor responses of visuomotor neurons merged into a single burst of action potentials, while the visual response of visual-only neurons was unaffected. A linear combination model was used to test which SC signals best predicted the likelihood of producing an express saccade. In addition to visual response magnitude and previsual activity of saccade neurons, the model identified presaccadic activity (activity occurring during the 30-ms epoch immediately before saccade initiation) as a third important signal for predicting express saccades. We conclude that express saccades can be predicted by visual, previsual, and presaccadic signals recorded from visuomotor neurons in the intermediate layers of the SC. PMID:26063770

WE-D-9A-06: Open Source Monitor Calibration and Quality Control Software for Enterprise Display Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bevins, N; Vanderhoek, M; Lang, S

2014-06-15

Purpose: Medical display monitor calibration and quality control present challenges to medical physicists. The purpose of this work is to demonstrate and share experiences with an open source package that allows for both initial monitor setup and routine performance evaluation. Methods: A software package, pacsDisplay, has been developed over the last decade to aid in the calibration of all monitors within the radiology group in our health system. The software is used to calibrate monitors to follow the DICOM Grayscale Standard Display Function (GSDF) via lookup tables installed on the workstation. Additional functionality facilitates periodic evaluations of both primary andmore » secondary medical monitors to ensure satisfactory performance. This software is installed on all radiology workstations, and can also be run as a stand-alone tool from a USB disk. Recently, a database has been developed to store and centralize the monitor performance data and to provide long-term trends for compliance with internal standards and various accrediting organizations. Results: Implementation and utilization of pacsDisplay has resulted in improved monitor performance across the health system. Monitor testing is now performed at regular intervals and the software is being used across multiple imaging modalities. Monitor performance characteristics such as maximum and minimum luminance, ambient luminance and illuminance, color tracking, and GSDF conformity are loaded into a centralized database for system performance comparisons. Compliance reports for organizations such as MQSA, ACR, and TJC are generated automatically and stored in the same database. Conclusion: An open source software solution has simplified and improved the standardization of displays within our health system. This work serves as an example method for calibrating and testing monitors within an enterprise health system.« less

UNTANGLING THE NEAR-IR SPECTRAL FEATURES IN THE PROTOPLANETARY ENVIRONMENT OF KH 15D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arulanantham, Nicole A.; Herbst, William; Gilmore, Martha S.

2017-01-10

We report on Gemini/GNIRS observations of the binary T Tauri system V582 Mon (KH 15D) at three orbital phases. These spectra allow us to untangle five components of the system: the photosphere and magnetosphere of star B, the jet, scattering properties of the ring material, and excess near-infrared (near-IR) radiation previously attributed to a possible self-luminous planet. We confirm an early-K subgiant classification for star B and show that the magnetospheric He i emission line is variable, possibly indicating increased mass accretion at certain times. As expected, the H{sub 2} emission features associated with the inner part of the jetmore » show no variation with orbital phase. We show that the reflectance spectrum for the scattered light has a distinctive blue slope and spectral features consistent with scattering and absorption by a mixture of water and methane ice grains in the 1–50 μ m size range. This suggests that the methane frost line is closer than ∼5 au in this system, requiring that the grains be shielded from direct radiation. After correcting for features from the scattered light, jet, magnetosphere, and photosphere, we confirm the presence of leftover near-IR light from an additional source, detectable near minimum brightness. A spectral emission feature matching the model spectrum of a 10 M {sub J}, 1 Myr old planet is found in the excess flux, but other expected features from this model are not seen. Our observations, therefore, tentatively support the picture that a luminous planet is present within the system, although they cannot yet be considered definitive.« less

The First Hyper-Luminous Infrared Galaxy Discovered by WISE

NASA Technical Reports Server (NTRS)

Eisenhardt, Peter R.; Wu, Jingwen; Tsai, Chao-Wei; Assef, Roberto; Benford, Dominic; Blain, Andrew; Bridge, Carrie; Condon, J. J.; Cushing, Michael C.; Cutri, Roc;

Comparison of Segmental Versus Longitudinal Intravascular Ultrasound Analysis for Pediatric Cardiac Allograft Vasculopathy.

PubMed

Kuhn, M A; Burch, M; Chinnock, R E; Fenton, M J

2017-10-01

Intravascular ultrasound (IVUS) has been routinely used in some centers to investigate cardiac allograft vasculopathy in pediatric heart transplant recipients. We present an alternative method using more sophisticated imaging software. This study presents a comparison of this method with an established standard method. All patients who had IVUS performed in 2014 were retrospectively evaluated. The standard technique consisted of analysis of 10 operator-selected segments along the vessel. Each study was re-evaluated using a longitudinal technique, taken at every third cardiac cycle, along the entire vessel. Semiautomatic edge detection software was used to detect vessel imaging planes. Measurements included outer and inner diameter, total and luminal area, maximal intimal thickness (MIT), and intimal index. Each IVUS was graded for severity using the Stanford classification. All results were given as mean ± standard deviation (SD). Groups were compared using Student t test. A P value <.05 was considered significant. There were 59 IVUS studies performed on 58 patients. There was no statistically significant difference between outer diameter, inner diameter, or total area. In the longitudinal group, there was a significantly smaller luminal area, higher MIT, and higher intimal index. Using the longitudinal technique, there was an increase in Stanford classification in 20 patients. The longitudinal technique appeared more sensitive in assessing the degree of cardiac allograft vasculopathy and may play a role in the increase in the degree of thickening seen. It may offer an alternative way of grading severity of cardiac allograft vasculopathy in pediatric heart transplant recipients. Copyright © 2017 Elsevier Inc. All rights reserved.

Antagonism Between Luminal and Caffeine, Studied by the Use of Radioisotopes; RECHERCHES SUR LES BARBITURIQUES RADIOACTIFS: LA DISTRIBUTION DU LUMINAL DANS L'ORGANISME ANIMAL EN PRESENCE DE CAFEINE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aliprandi, B.; Masironi, R.

1959-10-31

The normal pattern of distribution of luminal in the animal organism was determined in mice using a tracer technique. The effect of an antagonistic drug, e.g., caffeine, on this normal distribution pattern was studied. The results confirmed the hypothesis of the in vivo breaking of the barbituric ring. (J.S.R.)

Estimation of errors in luminance signals encoded by primate retina resulting from sampling of natural images with red and green cones.

PubMed

Osorio, D; Ruderman, D L; Cronin, T W

1998-01-01

Both long-wavelength-sensitive (L) and medium-wavelength-sensitive (M) cones contribute to luminance mechanisms in human vision. This means that luminance and chromatic signals may be confounded. We use power spectra from natural images to estimate the magnitude of the corruption of luminance signals encoded by an array of retinal ganglion cells resembling the primate magnocellular neurons. The magnitude of this corruption is dependent on the cone lattice and is most severe where cones form clumps of a single spectral type. We find that chromatic corruption may equal or exceed the amplitude of other sources of noise and so could impose constraints on visual performance and on eye design.

Distribution and Identification of Luminous Bacteria from the Sargasso Sea

PubMed Central

Orndorff, S. A.; Colwell, R. R.

1980-01-01

Vibrio fischeri and Lucibacterium harveyi constituted 75 of the 83 luminous bacteria isolated from Sargasso Sea surface waters. Photobacterium leiognathi and Photobacterium phosphoreum constituted the remainder of the isolates. Luminescent bacteria were recovered at concentrations of 1 to 63 cells per 100 ml from water samples collected at depths of 160 to 320 m. Two water samples collected at the thermocline yielded larger numbers of viable, aerobic heterotrophic and luminous bacteria. Luminescent bacteria were not recovered from surface microlayer samples. The species distribution of the luminous bacteria reflected previously recognized growth patterns; i.e., L. harveyi and V. fischeri were predominant in the upper, warm waters (only one isolate of P. phosphoreum was obtained from surface tropical waters). PMID:16345575

Variable area nozzle including a plurality of convexly vanes with a crowned contour, in a vane to vane sealing arrangement and with nonuniform lengths

NASA Technical Reports Server (NTRS)

Arnold, Steven M. (Inventor); Penney, Nicholas (Inventor)

2008-01-01

A variable area nozzle comprising a concentric support and a plurality of convexly contoured self sealing vanes is disclosed and claimed. The vanes are circumferentially and rotatably mounted to the concentric support forming a nozzle infinitely positionable between a first position corresponding to a minimum area nozzle and a second position corresponding to a maximum area nozzle. A closer, which is preferably a shape memory alloy (SMA), urges the nozzle toward the first position corresponding to a minimum area nozzle. Periodically spaced openers act between adjacent vanes to urge the nozzle to a second position corresponding to a maximum area nozzle.

Flux of Kilogram-sized Meteoroids from Lunar Impact Monitoring. Supplemental Movies

NASA Technical Reports Server (NTRS)

Suggs, Robert; Cooke, William; Suggs, Ron; McNamara, Heather; Swift, Wesley; Moser, Danielle; Diekmann, Anne

2008-01-01

These videos, and audio accompany the slide presentation "Flux of Kilogram-sized Meteoroids from Lunar Impact Monitoring." The slide presentation reviews the routine lunar impact monitoring that has harvested over 110 impacts in 2 years of observations using telescopes and low-light level video cameras. The night side of the lunar surface provides a large collecting area for detecting these impacts and allows estimation of the flux of meteoroids down to a limiting luminous energy.

Image and Sensor Data Processing for Target Acquisition and Recognition.

DTIC Science & Technology

1980-11-01

technological, cost, size and weight constraints. The critical problem seems to be detecting the target with an acceptable false alarm rate, rather than...for its operation, loss of detail can result from adjacent differing pixels being forced into the same displayed grey-level. This may be detected in...a) Enhanced (b) Fig.1 High contrast scene demonstrating loss of detail in a local area of low contrast Luminance T V Black Peak white wavelength 1

An imaging-based photometric and colorimetric measurement method for characterizing OLED panels for lighting applications

NASA Astrophysics Data System (ADS)

Zhu, Yiting; Narendran, Nadarajah; Tan, Jianchuan; Mou, Xi

2014-09-01

The organic light-emitting diode (OLED) has demonstrated its novelty in displays and certain lighting applications. Similar to white light-emitting diode (LED) technology, it also holds the promise of saving energy. Even though the luminous efficacy values of OLED products have been steadily growing, their longevity is still not well understood. Furthermore, currently there is no industry standard for photometric and colorimetric testing, short and long term, of OLEDs. Each OLED manufacturer tests its OLED panels under different electrical and thermal conditions using different measurement methods. In this study, an imaging-based photometric and colorimetric measurement method for OLED panels was investigated. Unlike an LED that can be considered as a point source, the OLED is a large form area source. Therefore, for an area source to satisfy lighting application needs, it is important that it maintains uniform light level and color properties across the emitting surface of the panel over a long period. This study intended to develop a measurement procedure that can be used to test long-term photometric and colorimetric properties of OLED panels. The objective was to better understand how test parameters such as drive current or luminance and temperature affect the degradation rate. In addition, this study investigated whether data interpolation could allow for determination of degradation and lifetime, L70, at application conditions based on the degradation rates measured at different operating conditions.

Agreement between methods of measurement of mean aortic wall thickness by MRI.

PubMed

Rosero, Eric B; Peshock, Ronald M; Khera, Amit; Clagett, G Patrick; Lo, Hao; Timaran, Carlos

2009-03-01

To assess the agreement between three methods of calculation of mean aortic wall thickness (MAWT) using magnetic resonance imaging (MRI). High-resolution MRI of the infrarenal abdominal aorta was performed on 70 subjects with a history of coronary artery disease who were part of a multi-ethnic population-based sample. MAWT was calculated as the mean distance between the adventitial and luminal aortic boundaries using three different methods: average distance at four standard positions (AWT-4P), average distance at 100 automated positions (AWT-100P), and using a mathematical computation derived from the total vessel and luminal areas (AWT-VA). Bland-Altman plots and Passing-Bablok regression analyses were used to assess agreement between methods. Bland-Altman analyses demonstrated a positive bias of 3.02+/-7.31% between the AWT-VA and the AWT-4P methods, and of 1.76+/-6.82% between the AWT-100P and the AWT-4P methods. Passing-Bablok regression analyses demonstrated constant bias between the AWT-4P method and the other two methods. Proportional bias was, however, not evident among the three methods. MRI methods of measurement of MAWT using a limited number of positions of the aortic wall systematically underestimate the MAWT value compared with the method that calculates MAWT from the vessel areas. Copyright (c) 2009 Wiley-Liss, Inc.

Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects

PubMed Central

2012-01-01

Background Growing evidence suggests that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). In this study, we explored gender disparities in EAT volume (EATV) and its impact on coronary atherosclerosis. Methods The study population consisted of 90 consecutive subjects (age: 63 ± 12 years; men: 47, women: 43) who underwent 256-slice multi-detector computed tomography (MDCT) coronary angiography. EATV was measured as the sum of cross-sectional epicardial fat area on CT images, from the lower surface of the left pulmonary artery origin to the apex. Subjects were segregated into the CAD group (coronary luminal narrowing > 50%) and non-CAD group. Results EATV/body surface area (BSA) was higher among men in the CAD group than in the non-CAD group (62 ± 13 vs. 33 ± 10 cm3/m2, p < 0.0001), but did not differ significantly among women in the 2 groups (49 ± 18 vs. 42 ± 9 cm3/m2, not significant). Multivariate logistic analysis showed that EATV/BSA was the single predictor for >50% coronary luminal narrowing in men (p < 0.0001). Predictors excluded were age, body mass index, hypertension, diabetes mellitus, and hyperlipidemia. Conclusions Increased EATV is strongly associated with coronary atherosclerosis in men. PMID:22963346

Clinicopathological predictors of long-term benefit in breast cancer treated with neoadjuvant chemotherapy

PubMed Central

Galvez, Marco; Castaneda, Carlos A; Sanchez, Joselyn; Castillo, Miluska; Rebaza, Lia Pamela; Calderon, Gabriela; Cruz, Miguel De La; Cotrina, Jose Manuel; Abugattas, Julio; Dunstan, Jorge; Guerra, Henry; Mejia, Omar; Gomez, Henry L

2018-01-01

AIM To investigate the survival impact of clinicopathological factors, including pathological complete response (pCR) and tumor-infiltrating lymphocytes (sTIL) levels according to subtypes, in breast cancer (BC) patients who received neo-adjuvant chemotherapy (NAC). METHODS We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. sTIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preNAC core biopsy. pCR was considered in the absence of infiltrating cancer cells in primary tumor and axillary lymph nodes. Analysis of statistical association between clinical pathological features, sTIL, pCR and survival were carried out using SPSSvs19. RESULTS Median age was 49 years (range 24-84 years) and the most frequent clinical stage was IIIB (58.3%). Luminal A, Luminal B, HER2-enriched and (triple-negative) TN phenotype was found in 24.6%, 37.9%, 17.7% and 19.8%, respectively. pCR was observed in 11% and median percentage of sTIL was 40% (2%-95%) in the whole population. pCR was associated to Ct1-2 (P = 0.045) and to high sTIL (P = 0.029) in the whole population. There was a slight trend towards significance for sTIL (P = 0.054) in Luminal A. sTIL was associated with grade III (P < 0.001), no-Luminal A subtype (P < 0.001), RE-negative (P < 0.001), PgR-negative (P < 0.001), HER2-positive (P = 0.002) and pCR (P = 0.029) in the whole population. Longer disease-free survival was associated with grade I-II (P = 0.006), cN0 (P < 0.001), clinical stage II (P = 0.004), ER-positive (P < 0.001), PgR-positive (P < 0.001), luminal A (P < 0.001) and pCR (P = 0.002). Longer disease-free survival was associated with grade I-II in Luminal A (P < 0.001), N0-1 in Luminal A (P = 0.045) and TNBC (P = 0.01), clinical stage II in Luminal A (P = 0.003) and TNBC (P = 0.038), and pCR in TNBC (P < 0.001). Longer overall survival was associated with grade I-II (P < 0.001), ER-positive (P < 0.001), PgR-positive (P < 0.001), Luminal A (P < 0.001), cN0 (P = 0.002) and pCR (P = 0.002) in the whole population. Overall survival was associated with clinical stage II (P = 0.017) in Luminal A, older age (P = 0.042) in Luminal B, and pCR in TNBC (P = 0.005). CONCLUSION Predictive and prognostic values of clinicopathological features, like pCR and sTIL, differ depending on the evaluated molecular subtype PMID:29651385

An exploration of complementary feeding of infants and young children in the rural area of Muhoroni, Nyanza province, Kenya: a descriptive study.

PubMed

Harvey, Sophie; Callaby, Jo; Roberts, Lesley

2017-08-01

Inappropriate infant and young child feeding practices contribute to malnutrition, infection and long-term development limitation. To explore complementary feeding and food safety in Muhoroni District, Nyanza Province in rural Kenya. To compare practices with the Infant and Young Child Feeding (IYCF) guidelines, and identify associations with inappropriate practices. Between January and April 2014, a questionnaire completed by primary caregivers of children aged 6-23 months asked about foods the child had received in the previous 24 hours, the introduction of complementary foods, and the food hygiene practices undertaken by the caregiver. The most recent World Health Organization IYCF core indicators (continued breastfeeding at 1 year; minimum dietary diversity; minimum meal frequency; minimum acceptable diet) were determined for 400 children. These indicators were compared with demographic indicators in multivariate analyses to identify associations with appropriate complementary feeding practices. A total of 55.2% of children aged 12-15 months continued to be breastfed at the time of questioning. Of the study population, 61.5% achieved minimum dietary diversity, 70.8% achieved minimum meal frequency and 43.0% achieved minimum acceptable diet. Older children were more likely to achieve minimum dietary diversity and minimum acceptable diet; however, they were also less likely to achieve minimum meal frequency. High levels of hygiene practices were reported in all areas of food safety. Complementary feeding indicators were higher than nationally, although less than half of children (43.0%) were receiving a minimum acceptable diet. Further work should explore the potential relationship between age and adequate infant feeding.

24 CFR 3280.110 - Minimum room dimensions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Minimum room dimensions. The gross floor area required by § 3280.110 (a) and (b) shall have no clear horizontal dimension less than 5 feet except as permitted by § 3280.102(a). [40 FR 58752, Dec. 18, 1975... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Minimum room dimensions. 3280.110...

24 CFR 3280.110 - Minimum room dimensions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Minimum room dimensions. The gross floor area required by § 3280.110 (a) and (b) shall have no clear horizontal dimension less than 5 feet except as permitted by § 3280.102(a). [40 FR 58752, Dec. 18, 1975... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Minimum room dimensions. 3280.110...

24 CFR 3280.110 - Minimum room dimensions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Minimum room dimensions. 3280.110... Minimum room dimensions. The gross floor area required by § 3280.110 (a) and (b) shall have no clear horizontal dimension less than 5 feet except as permitted by § 3280.102(a). [40 FR 58752, Dec. 18, 1975...

75 FR 18256 - Petition for Exemption; Summary of Petition Received

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... an exemption from the specific dimensions of the passenger entry door of the Hawker Beechcraft Model 390-2. The door has basic dimensions greater than the minimum required by Sec. 23.783(f)(1). The total... than the minimum area required by Sec. 23.783(f)(1); however, the minimum width dimension cannot be met...

24 CFR 3280.110 - Minimum room dimensions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Minimum room dimensions. 3280.110... Minimum room dimensions. The gross floor area required by § 3280.110 (a) and (b) shall have no clear horizontal dimension less than 5 feet except as permitted by § 3280.102(a). [40 FR 58752, Dec. 18, 1975...

24 CFR 3280.110 - Minimum room dimensions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Minimum room dimensions. 3280.110... Minimum room dimensions. The gross floor area required by § 3280.110 (a) and (b) shall have no clear horizontal dimension less than 5 feet except as permitted by § 3280.102(a). [40 FR 58752, Dec. 18, 1975...

Interleukin-10 neutralizing antibody for detection of intestinal luminal levels and as a dietary additive in Eimeria challenged broiler chicks.

PubMed

Arendt, Maria K; Sand, Jordan M; Marcone, Taylor M; Cook, Mark E

2016-02-01

Interleukin-10 (IL-10) mRNA levels are increased within intestinal mucosa after Eimeria infection. IL-10 apical receptor presence on enterocytes suggests IL-10 is secreted into the intestinal lumen. Increased IL-10 has been shown to be central to the pathogenesis of numerous intracellular pathogens; we hypothesize luminal secretion of IL-10 enables Eimeria spp. infection in chickens. This study examines intestine luminal IL-10 levels and performance in broilers challenged with Eimeria when fed an anti-IL-10 antibody. Chicks were fed a diet (1 to 21 d) with control or anti-IL-10 antibody (0.34 g egg yolk antibody powder/Kg diet) with a saline or 10× dose of Advent coccidiosis vaccine on d 3. One chick per pen was euthanized on days 2, 4, 7, 10, 13, 16, and 19 post-challenge, bled, and intestines were collected for luminal fluid IL-10 concentrations. Body weight and feed intake were measured on d 21, and oocyst shedding was assessed on d 7 post-challenge. A significant Eimeria × antibody interaction on d 21 body weight (P < 0.05) showed chicks fed control antibody, but not anti-IL-10, had significant reductions in body weight when challenged with Eimeria spp. Oocyst shedding was increased with Eimeria challenge, but dietary antibody had no effect. Plasma carotenoid levels were reduced in Eimeria challenged chicks 4, 7, 10, and 16 days post-challenge compared to unchallenged chicks. Lack of an Eimeria × antibody interaction showed anti-IL-10 was not protective against Eimeria-induced decreases in plasma carotenoids. Eimeria challenge increased intestine luminal IL-10 on days 4 and 7 post-challenge in the cecum and jejunum, respectively, compared to unchallenged. Dietary anti-IL-10 decreased luminal IL-10 in the ileum on day 2 post-challenge when compared to control antibody fed chicks. No interaction between Eimeria challenge and antibody was observed on intestine luminal contents of IL-10, suggesting anti-IL-10 was ineffective at preventing increased Eimeria-induced luminal IL-10. In conclusion, Eimeria challenge increased intestinal luminal IL-10 and anti-IL-10 was effective at preventing Eimeria-induced decreased body weight, however the mechanism anti-IL-10 antibody protects body weight during Eimeria challenge remains unknown. © 2016 Poultry Science Association Inc.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Truong, Pauline T., E-mail: ptruong@bccancer.bc.ca; Breast Cancer Outcomes Unit, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, Victoria, BC; Sadek, Betro T.

Purpose: To examine locoregional and distant recurrence (LRR and DR) in women with pT1-2N0 breast cancer according to approximated subtype and clinicopathologic characteristics. Methods and Materials: Two independent datasets were pooled and analyzed. The study participants were 1994 patients with pT1-2N0M0 breast cancer, treated with mastectomy without radiation therapy. The patients were classified into 1 of 5 subtypes: luminal A (ER+ or PR+/HER 2−/grade 1-2, n=1202); luminal B (ER+ or PR+/HER 2−/grade 3, n=294); luminal HER 2 (ER+ or PR+/HER 2+, n=221); HER 2 (ER−/PR−/HER 2+, n=105) and triple-negative breast cancer (TNBC) (ER−/PR−/HER 2−, n=172). Results: The median follow-up timemore » was 4.3 years. The 5-year Kaplan-Meier (KM) LRR were 1.8% in luminal A, 3.1% in luminal B, 1.7% in luminal HER 2, 1.9% in HER 2, and 1.9% in TNBC cohorts (P=.81). The 5-year KM DR was highest among women with TNBC: 1.8% in luminal A, 5.0% in luminal B, 2.4% in luminal HER 2, 1.1% in HER 2, and 9.6% in TNBC cohorts (P<.001). Among 172 women with TNBC, the 5-year KM LRR were 1.3% with clear margins versus 12.5% with close or positive margins (P=.04). On multivariable analysis, factors that conferred higher LRR risk were tumors >2 cm, lobular histology, and close/positive surgical margins. Conclusions: The 5-year risk of LRR in our pT1-2N0 cohort treated with mastectomy was generally low, with no significant differences observed between approximated subtypes. Among the subtypes, TNBC conferred the highest risk of DR and an elevated risk of LRR in the presence of positive or close margins. Our data suggest that although subtype alone cannot be used as the sole criterion to offer postmastectomy radiation therapy, it may reasonably be considered in conjunction with other clinicopathologic factors including tumor size, histology, and margin status. Larger cohorts and longer follow-up times are needed to define which women with node-negative disease have high postmastectomy LRR risks in contemporary practice.« less

76 FR 56433 - Loveland Area Projects-Western Area Colorado Missouri Balancing Authority-Rate Order No. WAPA-155

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-13

... settled (minimum 4 MW) of metered load settled using WACM hourly pricing with no using WACM hourly pricing... than 7.5% (minimum pricing in no-penalty band. Customer 10 MW) of metered load settled using imbalance... or equal to 0.5 percent of its hourly average load, no Regulation Service charges will be assessed by...

Flame and Soot Boundaries of Laminar Jet Diffusion Flames. Appendix A

NASA Technical Reports Server (NTRS)

Xu, F.; Dai, Z.; Faeth, G. M.; Yuan, Z.-G. (Technical Monitor); Urban, D. L. (Technical Monitor); Yuan, Z.-G. (Technical Monitor)

2002-01-01

The shapes (flame-sheet and luminous-flame boundaries) or steady weakly buoyant round hydrocarbon-fueled laminar-jet diffusion flames in still and coflowing air were studied both experimentally and theoretically. Flame-sheet shapes were measured from photographs using a CH optical filter to distinguish flame-sheet boundaries in the presence of blue CO2 and OH emissions and yellow continuum radiation from soot. Present experimental conditions included acetylene-, methane-, propane-, and ethylene-fueled flames having initial reactant temperatures of 300 K. ambient pressures of 4-50 kPa, jet-exit Reynolds numbers of 3-54, initial air/fuel velocity ratios of 0-9, and luminous flame lengths of 5-55 mm; earlier measurements for propylene- and 1,3-butadiene-fueled flames for similar conditions were considered as well. Nonbuoyant flames in still air were observed at microgravity conditions; essentially nonbuoyant flames in coflowing air were observed at small pressures to control effects of buoyancy. Predictions of luminous flame boundaries from soot luminosity were limited to laminar smoke-point conditions, whereas predictions of flame-sheet boundaries ranged from soot-free to smoke-point conditions. Flame-shape predictions were based on simplified analyses using the boundary-layer approximations along with empirical parameters to distinguish flame-sheet and luminous-flame (at the laminar smoke point) boundaries. The comparison between measurements and predictions was remarkably good and showed that both flame-sheet and luminous-flame lengths are primarily controlled by fuel flow rates with lengths in coflowing air approaching 2/3 of the lengths in still air as coflowing air velocities are increased. Finally, luminous flame lengths at laminar smoke-point conditions were roughly twice as long as flame-sheet lengths at comparable conditions because of the presence of luminous soot particles in the fuel-lean region of the flames.

Luminal glucose concentrations in the gut under normal conditions.

PubMed

Ferraris, R P; Yasharpour, S; Lloyd, K C; Mirzayan, R; Diamond, J M

1990-11-01

Luminal glucose (Glc) concentrations in the small intestine (SI) are widely assumed to be 50-500 mM. These values have posed problems for interpreting SI luminal osmolality and absorptive capacity, Glc transporter Michaelis-Menten constants (Km), and the physiological role of active Glc transport and its regulation. Hence we measured luminal contents, osmolality, and Glc, Na+, and K+ concentrations in normally feeding rats, rabbits, and dogs. Measured Glc concentrations were compatible with the portion of measured osmolality not accounted for by Na+ and K+ salts, amino acids, and peptides. Mean SI luminal osmolalities were less than or equal to 100 mosmol/kg hypertonic. For animals on the most nearly physiological diets, SI Glc concentrations averaged 0.4-24 mM and ranged with time and SI region from 0.2 to a maximum of 48 mM. The older published very high values are artifacts of direct infusion of concentrated Glc solutions into the gut, nonspecific Glc assays, and failure to test for quantitative recovery or to centrifuge samples in the cold. By storing food after meals and releasing it between meals, rat stomach greatly damps diurnal fluctuations in quantity and osmolality of food reaching the SI and hence also damps fluctuations in absorption rates. These new values for luminal Glc have five important physiological implications: the problem of accounting for apparently very hypertonic SI contents in the face of high osmotic water permeability disappears; the effective Km of the SI Glc transporter is now comparable to prevailing Glc concentrations; the SI no longer appears to have enormous excess absorptive capacity for Glc; regulation of Glc transport by dietary intake now makes functional sense; and the claim that high luminal Glc concentrations permit solvent drag to become the major mode of Glc absorption under normal conditions is undermined.

Ambient illumination revisited: A new adaptation-based approach for optimizing medical imaging reading environments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chawla, Amarpreet S.; Samei, Ehsan; Duke Advanced Imaging Laboratories, Departments of Radiology, Physics, Medical Physics, and Biomedical Engineering, Duke University, Durham, North Carolina 27705

2007-01-15

Ambient lighting in soft-copy reading rooms is currently kept at low values to preserve contrast rendition in the dark regions of a medical image. Low illuminance levels, however, create inadequate viewing conditions and may also cause eye strain. This eye strain may be potentially attributed to notable variations in the luminance adaptation state of the reader's eyes when moving the gaze intermittently between the brighter display and darker surrounding surfaces. This paper presents a methodology to minimize this variation and optimize the lighting conditions of reading rooms by exploiting the properties of liquid crystal displays (LCDs) with low diffuse reflectionmore » coefficients and high luminance ratio. First, a computational model was developed to determine a global luminance adaptation value, L{sub adp}, when viewing a medical image on display. The model is based on the diameter of the pupil size, which depends on the luminance of the observed object. Second, this value was compared with the luminance reflected off surrounding surfaces, L{sub s}, under various conditions of room illuminance, E, different values of diffuse reflection coefficients of surrounding surfaces, R{sub s}, and calibration settings of a typical LCD. The results suggest that for typical luminance settings of current LCDs, it is possible to raise ambient illumination to minimize differences in eye adaptation, potentially reducing visual fatigue while also complying with the TG18 specifications for controlled contrast rendition. Specifically, room illumination in the 75-150 lux range and surface diffuse reflection coefficients in the practical range of 0.13-0.22 sr{sup -1} provide an ideal setup for typical LCDs. Future LCDs with lower diffuse reflectivity and with higher inherent luminance ratios can provide further improvement of ergonomic viewing conditions in reading rooms.« less

The selective cyclooxygenase-2 inhibitor parecoxib markedly improves the ability of the duodenum to regulate luminal hypertonicity in anaesthetized rats.

PubMed

Sedin, J; Sjöblom, M; Nylander, O

2012-07-01

To examine whether the prevention of post-operative duodenal ileus by treatment with parecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, affects the ability of the duodenum to respond to luminal hypertonicity. The proximal duodenums of anaesthetized rats were perfused with hypertonic NaCl solutions with osmolalities of 400, 500, 600 or 700 mOsm kg(-1) , and the effects on mucosal permeability, motility, transepithelial net fluid flux and effluent osmolality were assessed in the absence (control) and presence of parecoxib. Parecoxib-treated, but not control animals, exhibited duodenal contractions, which were reduced by the nicotinic receptor antagonists mecamylamine and hexamethonium and by perfusion with 700 mOsm kg(-1) . All animals responded to luminal hypertonicity with induction of net fluid secretion, which peaked at an osmolality of 500 mOsm kg(-1) . The hypertonicity-induced increases in fluid secretion were twofold greater in parecoxib-treated than in control rats and attenuated by nicotinic receptor blockade. The decrease in luminal osmolality correlated with the osmolality of the perfusion solution in both control and parecoxib-treated animals but the osmolality-adjusting capability was markedly better in the latter group. Rats exposed to duodenal luminal distension responded to hypertonicity with a greater fluid secretion and a larger decrease in luminal osmolality than control rats. Perfusion with 700 mOsm kg(-1) increased mucosal permeability in parecoxib-treated animals only, an effect abolished by nicotinic receptor blockade. Parecoxib markedly improved the ability of the duodenum to sense and to decrease luminal hypertonicity by a mechanism most probably involving inhibition of COX-2 and stimulation of nicotinic acetylcholine receptors. © 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.

Tamoxifen therapy improves overall survival in luminal A subtype of ductal carcinoma in situ: a study based on nationwide Korean Breast Cancer Registry database.

PubMed

Hwang, Ki-Tae; Kim, Eun-Kyu; Jung, Sung Hoo; Lee, Eun Sook; Kim, Seung Il; Lee, Seokwon; Park, Heung Kyu; Kim, Jongjin; Oh, Sohee; Kim, Young A

2018-06-01

To determine the prognostic role of tamoxifen therapy for patients with ductal carcinoma in situ (DCIS) according to molecular subtypes. Data of 14,944 patients with DCIS were analyzed. Molecular subtypes were classified into four categories based on expression of estrogen receptor (ER)/progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Kaplan-Meier estimator was used for overall survival analysis while Cox proportional hazards model was used for univariate and multivariate analyses. Luminal A subtype (ER/PR+, HER2-) showed higher (P = .009) survival rate than triple-negative (TN) subtype. Tamoxifen therapy group showed superior (P < .001) survival than no-tamoxifen therapy group. It had survival benefit only for luminal A subtype (P = .001). Tamoxifen therapy resulted in higher survival rate in subgroups with positive ER (P = .006), positive PR (P = .009), and negative HER2 (P < .001). In luminal A subtype, tamoxifen therapy showed lower hazard ratio (HR) compared to no-tamoxifen therapy (HR, 0.420; 95% CI 0.250-0.705; P = .001). Tamoxifen therapy was a significant independent factor by multivariate analysis (HR, 0.538; 95% CI 0.306-0.946; P = .031) as well as univariate analysis. Tamoxifen therapy group showed superior prognosis than the no-tamoxifen therapy group. Its prognostic influence was only effective for luminal A subtype. Patients with luminal A subtype showed higher survival rate than those with TN subtype. Active tamoxifen therapy is recommended for DCIS patients with luminal A subtype, and routine tests for ER, PR, and HER2 should be considered for DCIS.

Intrinsic subtypes from PAM50 gene expression assay in a population-based breast cancer cohort: differences by age, race, and tumor characteristics.

PubMed

Sweeney, Carol; Bernard, Philip S; Factor, Rachel E; Kwan, Marilyn L; Habel, Laurel A; Quesenberry, Charles P; Shakespear, Kaylynn; Weltzien, Erin K; Stijleman, Inge J; Davis, Carole A; Ebbert, Mark T W; Castillo, Adrienne; Kushi, Lawrence H; Caan, Bette J

2014-05-01

Data are lacking to describe gene expression-based breast cancer intrinsic subtype patterns for population-based patient groups. We studied a diverse cohort of women with breast cancer from the Life After Cancer Epidemiology and Pathways studies. RNA was extracted from 1 mm punches from fixed tumor tissue. Quantitative reverse-transcriptase PCR was conducted for the 50 genes that comprise the PAM50 intrinsic subtype classifier. In a subcohort of 1,319 women, the overall subtype distribution based on PAM50 was 53.1% luminal A, 20.5% luminal B, 13.0% HER2-enriched, 9.8% basal-like, and 3.6% normal-like. Among low-risk endocrine-positive tumors (i.e., estrogen and progesterone receptor positive by immunohistochemistry, HER2 negative, and low histologic grade), only 76.5% were categorized as luminal A by PAM50. Continuous-scale luminal A, luminal B, HER2-enriched, and normal-like scores from PAM50 were mutually positively correlated. Basal-like score was inversely correlated with other subtypes. The proportion with non-luminal A subtype decreased with older age at diagnosis, P Trend < 0.0001. Compared with non-Hispanic Whites, African American women were more likely to have basal-like tumors, age-adjusted OR = 4.4 [95% confidence intervals (CI), 2.3-8.4], whereas Asian and Pacific Islander women had reduced odds of basal-like subtype, OR = 0.5 (95% CI, 0.3-0.9). Our data indicate that over 50% of breast cancers treated in the community have luminal A subtype. Gene expression-based classification shifted some tumors categorized as low risk by surrogate clinicopathologic criteria to higher-risk subtypes. Subtyping in a population-based cohort revealed distinct profiles by age and race. ©2014 AACR.

STUDIES ON BIOLUMINESCENCE : XVII. FLUORESCENCE AND INHIBITION OF LUMINESCENCE IN CTENOPHORES BY ULTRA-VIOLET LIGHT.

PubMed

Harvey, E N

1925-01-20

1. Small dumps of the luminous cells of Mnemiopsis cannot readily be stimulated mechanically but will luminesce on treatment with saponin solution. Larger groups of luminous cells (such as are connected with two paddle plates) luminesce on mechanical stimulation. This suggests that mechanical stimulation to luminesce occurs chiefly through a nerve mechanism which has been broken up in the small dumps of luminous tissue. 2. The smallest bits of luminous tissue, even cells freed from the animal by agitation, that will pass through filter paper, lose their power to luminesce in daylight and regain it (at least partially) in the dark. 3. Luminescence of the whole animal and of individual cells is suppressed by near ultra-violet light (without visible light). 4. Inhibition in ultra-violet light is not due to stimulation (by the ultra-violet light) of the animal to luminesce, thereby using up the store of photogenic material. 5. Animals stimulated mechanically several times and placed in ultra-violet light show a luminescence along the meridians in the same positions as the luminescence that appears on stimulation. This luminescence in the ultra-violet or "tonic luminescence," is not obtained with light adapted ctenophores and is interpreted to be a fluorescence of the product of oxidation of the photogenic material. 6. Marked fluorescence of the luminous organ of the glowworm (Photuris) and of the luminous slime of Chatopterus may be observed in ultra-violet but no marked fluorescence of the luminous substances of Cypridina is apparent. 7. Evidence is accumulating to show a close relation between fluorescent and chemiluminescent substances in animals, similar to that described for unsaturated silicon compounds and the Grignard reagents.

Molecular Subtypes of Indonesian Breast Carcinomas - Lack of Association with Patient Age and Tumor Size

PubMed Central

Rahmawati, Yeni; Setyawati, Yunita; Widodo, Irianiwati; Ghozali, Ahmad; Purnomosari, Dewajani

2018-01-01

Objective: Breast carcinoma (BC) is a heterogeneous disease that exhibits variation in biological behaviour, prognosis and response to therapy. Molecular classification is generally into Luminal A, Luminal B, HER2+ and triple negative/basal-like, depending on receptor characteristics. Clinical factors that determined the BC prognosis are age and tumor size. Since information on molecular subtypes of Indonesian BCs is limited, the present study was conducted, with attention to subtypes in relation to age and tumor size. Methods: A retrospective cross-sectional study of 247 paraffin-embedded samples of invasive BC from Dr. Sardjito General Hospital Yogyakarta in the year 2012- 2015 was performed. Immunohistochemical staining using anti- ER, PR, HER2, Ki-67 and CK 5/6 antibodies was applied to classify molecular subtypes. Associations with age and tumor size were analyzed using the Chi Square Test. Results: The Luminal A was the most common subtype of Indonesian BC (41.3%), followed by triple negative (25.5%), HER2 (19.4%) and luminal B (13.8%). Among the triple negative lesions, the basal-like subtype was more frequent than the non basal-like (58.8 % vs 41.2%). Luminal B accounted for the highest percentage of younger age cases (< 40 years old) while HER2+ was most common in older age (> 50 years old) patients. Triple negative/basal-like were commonly large in size. Age (p = 0.080) and tumor size (p = 0.462) were not significantly associated with molecular subtypes of BC. Conclusion: The most common molecular subtype of Indonesian BC is luminal A, followed by triple-negative, HER2+ and luminal B. The majority of triple-negative lesions are basal-like. There are no association between age and tumor size with molecular subtypes of Indonesian BCs. PMID:29373908

Molecular Subtypes of Indonesian Breast Carcinomas - Lack of Association with Patient Age and Tumor Size

PubMed

Rahmawati, Yeni; Setyawati, Yunita; Widodo, Irianiwati; Ghozali, Ahmad; Purnomosari, Dewajani

2018-01-27

Objective: Breast carcinoma (BC) is a heterogeneous disease that exhibits variation in biological behaviour, prognosis and response to therapy. Molecular classification is generally into Luminal A, Luminal B, HER2+ and triple negative/basal-like, depending on receptor characteristics. Clinical factors that determined the BC prognosis are age and tumor size. Since information on molecular subtypes of Indonesian BCs is limited, the present study was conducted, with attention to subtypes in relation to age and tumor size. Methods: A retrospective cross-sectional study of 247 paraffin-embedded samples of invasive BC from Dr. Sardjito General Hospital Yogyakarta in the year 2012- 2015 was performed. Immunohistochemical staining using anti- ER, PR, HER2, Ki-67 and CK 5/6 antibodies was applied to classify molecular subtypes. Associations with age and tumor size were analyzed using the Chi Square Test. Results: The Luminal A was the most common subtype of Indonesian BC (41.3%), followed by triple negative (25.5%), HER2 (19.4%) and luminal B (13.8%). Among the triple negative lesions, the basal-like subtype was more frequent than the non basal-like (58.8 % vs 41.2%). Luminal B accounted for the highest percentage of younger age cases (< 40 years old) while HER2+ was most common in older age (> 50 years old) patients. Triple negative/basal-like were commonly large in size. Age (p = 0.080) and tumor size (p = 0.462) were not significantly associated with molecular subtypes of BC. Conclusion: The most common molecular subtype of Indonesian BC is luminal A, followed by triple-negative, HER2+ and luminal B. The majority of triple-negative lesions are basal-like. There are no association between age and tumor size with molecular subtypes of Indonesian BCs. Creative Commons Attribution License

EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib.

PubMed

De Andrade, James P; Park, Jung M; Gu, Vivian W; Woodfield, George W; Kulak, Mikhail V; Lorenzen, Allison W; Wu, Vincent T; Van Dorin, Sarah E; Spanheimer, Philip M; Weigel, Ronald J

2016-03-01

Expression of TFAP2C in luminal breast cancer is associated with reduced survival and hormone resistance, partially explained through regulation of RET. TFAP2C also regulates EGFR in HER2 breast cancer. We sought to elucidate the regulation and functional role of EGFR in luminal breast cancer. We used gene knockdown (KD) and treatment with a tyrosine kinase inhibitor (TKI) in cell lines and primary cancer isolates to determine the role of RET and EGFR in regulation of p-ERK and tumorigenesis. KD of TFAP2C decreased expression of EGFR in a panel of luminal breast cancers, and chromatin immunoprecipitation sequencing (ChIP-seq) confirmed that TFAP2C targets the EGFR gene. Stable KD of TFAP2C significantly decreased cell proliferation and tumor growth, mediated in part through EGFR. While KD of RET or EGFR reduced proliferation (31% and 34%, P < 0.01), combined KD reduced proliferation greater than either alone (52% reduction, P < 0.01). The effect of the TKI vandetanib on proliferation and tumor growth response of MCF-7 cells was dependent upon expression of TFAP2C, and dual KD of RET and EGFR eliminated the effects of vandetanib. The response of primary luminal breast cancers to TKIs assessed by ERK activation established a correlation with expression of RET and EGFR. We conclude that TFAP2C regulates EGFR in luminal breast cancer. Response to vandetanib was mediated through the TFAP2C target genes EGFR and RET. Vandetanib may provide a therapeutic effect in luminal breast cancer, and RET and EGFR can serve as molecular markers for response. ©2016 American Association for Cancer Research.

EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib

PubMed Central

De Andrade, James P.; Park, Jung M.; Gu, Vivian W.; Woodfield, George W.; Kulak, Mikhail V.; Lorenzen, Allison W.; Wu, Vincent T.; Van Dorin, Sarah E.; Spanheimer, Philip M.; Weigel, Ronald J.

2016-01-01

Expression of TFAP2C in luminal breast cancer is associated with reduced survival and hormone resistance, partially explained through regulation of RET. TFAP2C also regulates EGFR in HER2 breast cancer. We sought to elucidate the regulation and functional role of EGFR in luminal breast cancer. We used gene knockdown (KD) and treatment with a tyrosine kinase inhibitor (TKI) in cell lines and primary cancer isolates to determine the role of RET and EGFR in regulation of p-ERK and tumorigenesis. KD of TFAP2C decreased expression of EGFR in a panel of luminal breast cancers and ChIP-seq confirmed that TFAP2C targets the EGFR gene. Stable KD of TFAP2C significantly decreased cell proliferation and tumor growth, mediated in part through EGFR. While KD of RET or EGFR reduced proliferation (31% and 34%, p < 0.01), combined KD reduced proliferation greater than either alone (52% reduction, p < 0.01). The effect of the TKI vandetanib on proliferation and tumor growth response of MCF-7 cells was dependent upon expression of TFAP2C and dual KD of RET and EGFR eliminated the effects of vandetanib. The response of primary luminal breast cancers to TKIs assessed by ERK activation established a correlation with expression of RET and EGFR. We conclude that TFAP2C regulates EGFR in luminal breast cancer. Response to vandetanib was mediated though the TFAP2C target genes EGFR and RET. Vandetanib may provide a therapeutic effect in luminal breast cancer, and RET and EGFR can serve as molecular markers for response. PMID:26832794

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruuge, A; Erdi, Y; Mahmood, U

Purpose: The conformance of Primary Diagnostic Monitors (PDMs) to the DICOM GSDF is increasingly required by several state and city regulators. Our purpose was to quantitatively characterize the luminance performance of the internal, built in photometer of BARCO monitors against an externally calibrated luminance meter. Methods: Thirty one PDMs (BARCO) were included in our analysis. An externally calibrated photometer (RaySafe Solo Light) was used to measure the luminance and illuminance values. Measured monitors were located at various hospital sites, radiology physicians’ offices and radiology reading rooms. All measured PDMs were equipped with the manufacturer’s built-in photometers and connected to Barcomore » MediCal QA web service for manual and automatic quality control measurements. PDM combinations included 1, 2 and 4 monitors depending on the location. TG-18 and SMPTE test patterns were used to evaluate monitor performance. Results: All the PDMs exceeded the luminance ratio of 250:1, as required by NYC PDM guidelines. One PDM failed the NYC requirement for the minimal luminance level of 350 cd/m2. As compared to the external photometer, the difference in measurement of the maximum luminance with the built-in photometer was found to exceed 5% on 6 of the PDM measured, with a maximum deviation of 10%. The age of the monitors that failed was on average 5 years. All monitors passed the luminance uniformity test, which was 30% from the center of the monitor to the 4 corner locations. Four PDMs failed the Gray Scale Display Function (GSDF) calibration. Conclusion: For the consistent display of medical images and continued conformance with the DICOM GSDF standard, it is essential to compare the performance of the built-in photometer with an externally calibrated photometer for monitors that are older than 5 years.« less

Body weight and risk of molecular breast cancer subtypes among postmenopausal Mediterranean women.

PubMed

Crispo, A; Montella, M; Buono, G; Grimaldi, M; D'Aiuto, M; Capasso, I; Esposito, E; Amore, A; Nocerino, F; Augustin, L S A; Giudice, A; Di Bonito, M; Giuliano, M; Forestieri, V; De Laurentiis, M; Rinaldo, M; Ciliberto, G; De Placido, S; Arpino, G

2016-01-01

Breast cancer (BC) is the most common malignant tumor in women, obesity is associated with increased BC incidence and mortality and high levels of circulating insulin may negatively impact on cancer incidence. In the present study, we investigated whether the strength of several anthropometric and metabolic parameters varies between BC molecular subtypes. Eligible cases were 991 non-metastatic BC patients recruited between January 2009 and December 2013. Anthropometric, clinical and immunohistochemical features were measured. Multivariate logistic regression models were built to assess HER2 positive BC risk, comparing (a) triple positive (TP) with luminal A, luminal B and triple negative (TN) and (b) HER2-enriched group with luminal A, luminal B and TN. We stratified patients in pre- and post-menopause: significant differences emerged for luminal A in relation to age: they were more likely to be older compared to other groups. Among postmenopausal patients, the adjusted multivariate analysis showed that high BMI and high waist circumference were inversely correlated to TP subtype when compared to luminal B (OR=0.48 and OR=0.49, respectively). Conversely, HOMA-IR was a risk factor for TP when compared to luminal A and TN (OR=2.47 and OR=3.15, respectively). Our findings suggest a potential role of higher abdominal fat in the development of specific BC molecular subtypes in postmenopausal women. Moreover, they support a potential role of insulin resistance in the development of HER2 positive BC, although this role appears to be stronger when hormone receptors are co-expressed, suggesting a difference in the etiology of these two BC subtypes. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Flame Shapes of Nonbuoyant Laminar Jet Diffusion Flames

NASA Technical Reports Server (NTRS)

Xu, F.; Dai, Z.; Faeth, G. M.; Urban, D. L. (Technical Monitor); Yuan, Z. G. (Technical Monitor)

2001-01-01

The shapes (flame-sheet and luminous-flame boundaries) of steady nonbuoyant round hydrocarbon-fueled laminar-jet diffusion flames in still and coflowing air were studied both experimentally and theoretically. Flame-sheet shapes were measured from photographs using a CH optical filter to distinguish flame-sheet boundaries in the presence of blue CO2 and OH emissions and yellow continuum radiation from soot. Present experimental conditions included acetylene-, methane-, propane-, and ethylene-fueled flames having initial reactant temperatures of 300 K, ambient pressures of 4-50 kPa, jet exit Reynolds number of 3-54, initial air/fuel velocity ratios of 0-9 and luminous flame lengths of 5-55 mm; earlier measurements for propylene- and 1,3-butadiene-fueled flames for similar conditions were considered as well. Nonbuoyant flames in still air were observed at micro-gravity conditions; essentially nonbuoyant flames in coflowing air were observed at small pressures to control effects of buoyancy. Predictions of luminous flame boundaries from soot luminosity were limited to laminar smokepoint conditions, whereas predictions of flame-sheet boundaries ranged from soot-free to smokepoint conditions. Flame-shape predictions were based on simplified analyses using the boundary layer approximations along with empirical parameters to distinguish flame-sheet and luminous flame (at the laminar smoke point) boundaries. The comparison between measurements and predictions was remarkably good and showed that both flame-sheet and luminous-flame lengths are primarily controlled by fuel flow rates with lengths in coflowing air approaching 2/3 lengths in still air as coflowing air velocities are increased. Finally, luminous flame lengths at laminar smoke-point conditions were roughly twice as long as flame-sheet lengths at comparable conditions due to the presence of luminous soot particles in the fuel-lean region of the flames.

Flame Shapes of Nonbuoyant Laminar Jet Diffusion Flames. Appendix K

NASA Technical Reports Server (NTRS)

Xu, F.; Faeth, G. M.; Urban, D. L. (Technical Monitor); Yuan, Z.-G. (Technical Monitor)

2000-01-01

The shapes (flame-sheet and luminous-flame boundaries) of steady nonbuoyant round hydrocarbon-fueled laminar-jet diffusion flames in still and coflowing air were studied both experimentally and theoretically. Flame-sheet shapes were measured from photographs using a CH optical filter to distinguish flame-sheet boundaries in the presence of blue C02 and OH emissions and yellow continuum radiation from soot. Present experimental conditions included acetylene-, methane-, propane-, and ethylene-fueled flames having initial reactant temperatures of 300 K, ambient pressures of 4-50 kPa, jet exit Reynolds number of 3-54, initial air/fuel velocity ratios of 0-9 and luminous flame lengths of 5-55 mm; earlier measurements for propylene- and 1,3-butadiene-fueled flames for similar conditions were considered as well. Nonbuoyant flames in still air were observed at micro-gravity conditions; essentially nonbuoyant flames in coflowing air were observed at small pressures to control effects of buoyancy. Predictions of luminous flame boundaries from soot luminosity were limited to laminar smoke-point conditions, whereas predictions of flame-sheet boundaries ranged from soot-free to smoke-point conditions. Flame-shape predictions were based on simplified analyses using the boundary layer approximations along with empirical parameters to distinguish flame-sheet and luminous-flame (at the laminar smoke point) boundaries. The comparison between measurements and predictions was remarkably good and showed that both flame-sheet and luminous-flame lengths are primarily controlled by fuel flow rates with lengths in coflowing air approaching 2/3 lengths in still air as coflowing air velocities are increased. Finally, luminous flame lengths at laminar smoke-point conditions were roughly twice as long as flame-sheet lengths at comparable conditions due to the presence of luminous soot particles in the fuel-lean region of the flames.

MicroRNA-139 suppresses proliferation in luminal type breast cancer cells by targeting Topoisomerase II alpha

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hua, Wei; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an; Sa, Ke-Di

The classification of molecular subtypes of breast cancer improves the prognostic accuracy and therapeutic benefits in clinic. However, because of the complexity of breast cancer, more biomarkers and functional molecules need to be explored. Here, analyzing the data in a huge cohort of breast cancer patients, we found that Topoisomerase II alpha (TOP2a), an important target of chemotherapy is a biomarker for prognosis in luminal type breast cancer patients, but not in basal like or HER2 positive breast cancer patients. We identified that miR-139, a previous reported anti-metastatic microRNA targets 3’-untranslated region (3′UTR) of TOP2a mRNA. Further more, we revealedmore » that the forced expression of miR-139 reduces the TOP2a expression at both mRNA and protein levels. And our functional experiments showed that the ectopic expression of miR-139 remarkably inhibits proliferation in luminal type breast cancer cells, while exogenous TOP2a expression could rescue inhibition of cell proliferation mediated by miR-139. Collectively, our present study demonstrates the miR-139-TOP2a regulatory axis is important for proliferation in luminal type breast cancer cells. This functional link may help us to further understand the specificity of subtypes of breast cancer and optimize the strategy of cancer treatment. - Highlights: • High levels of TOP2a expression are closely associated with poor prognosis in luminal type breast cancer patients. • TOP2a is a novel target of miR-139. • Overexpression of miR-139 inhibits proliferation in luminal type breast cancer cells. • TOP2a is essential for miR-139-induced growth arrest in luminal type breast cancer cells.« less

Miz1, a Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation.

PubMed

Berger, Penny L; Winn, Mary E; Miranti, Cindy K

2017-01-01

How prostate epithelial cells differentiate and how dysregulation of this process contributes to prostate tumorigenesis remain unclear. We recently identified a Myc target and chromatin reader protein, ING4, as a necessary component of human prostate luminal epithelial cell differentiation, which is often lost in primary prostate tumors. Furthermore, loss of ING4 in the context of oncogenic mutations is required for prostate tumorigenesis. Identifying the gene targets of ING4 can provide insight into how its loss disrupts differentiation and leads to prostate cancer. Using a combination of RNA-Seq, a best candidate approach, and chromatin immunoprecipitation (ChIP), we identified Miz1 as a new ING4 target. ING4 or Miz1 overexpression, shRNA knock-down, and a Myc-binding mutant were used in a human in vitro differentiation assay to assess the role of Miz1 in luminal cell differentiation. ING4 directly binds the Miz1 promoter and is required to induce Miz1 mRNA and protein expression during luminal cell differentiation. Miz1 mRNA was not induced in shING4 expressing cells or tumorigenic cells in which ING4 is not expressed. Miz1 dependency on ING4 was unique to differentiating luminal cells; Miz1 mRNA expression was not induced in basal cells. Although Miz1 is a direct target of ING4, and its overexpression can drive luminal cell differentiation, Miz1 was not required for differentiation. Miz1 is a newly identified ING4-induced target gene which can drive prostate luminal epithelial cell differentiation although it is not absolutely required. Prostate 77:49-59, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Measurement of luminance noise and chromaticity noise of LCDs with a colorimeter and a color camera

NASA Astrophysics Data System (ADS)

Roehrig, H.; Dallas, W. J.; Krupinski, E. A.; Redford, Gary R.

2007-09-01

This communication focuses on physical evaluation of image quality of displays for applications in medical imaging. In particular we were interested in luminance noise as well as chromaticity noise of LCDs. Luminance noise has been encountered in the study of monochrome LCDs for some time, but chromaticity noise is a new type of noise which has been encountered first when monochrome and color LCDs were compared in an ROC study. In this present study one color and one monochrome 3 M-pixel LCDs were studied. Both were DICOM calibrated with equal dynamic range. We used a Konica Minolta Chroma Meter CS-200 as well as a Foveon color camera to estimate luminance and chrominance variations of the displays. We also used a simulation experiment to estimate luminance noise. The measurements with the colorimeter were consistent. The measurements with the Foveon color camera were very preliminary as color cameras had never been used for image quality measurements. However they were extremely promising. The measurements with the colorimeter and the simulation results showed that the luminance and chromaticity noise of the color LCD were larger than that of the monochrome LCD. Under the condition that an adequate calibration method and image QA/QC program for color displays are available, we expect color LCDs may be ready for radiology in very near future.

Learning to Identify Near-Threshold Luminance-Defined and Contrast-Defined Letters in Observers with Amblyopia

PubMed Central

Chung, Susana T.L.; Li, Roger W.; Levi, Dennis M.

2008-01-01

We assessed whether or not the sensitivity for identifying luminance-defined and contrast-defined letters improved with training in a group of amblyopic observers who have passed the critical period of development. In Experiment 1, we tracked the contrast threshold for identifying luminance-defined letters with training in a group of 11 amblyopic observers. Following training, six observers showed a reduction in thresholds, averaging 20%, for identifying luminance-defined letters. This improvement transferred extremely well to the untrained task of identifying contrast-defined letters (average improvement = 38%) but did not transfer to an acuity measurement. Seven of the 11 observers were subsequently trained on identifying contrast-defined letters in Experiment 2. Following training, five of these seven observers demonstrated a further improvement, averaging 17%, for identifying contrast-defined letters. This improvement did not transfer to the untrained task of identifying luminance-defined letters. Our findings are consistent with predictions based on the locus of learning for first- and second-order stimuli according to the filter-rectifier-filter model for second-order visual processing. PMID:18824189

Planktonic Marine Luminous Bacteria: Species Distribution in the Water Column

PubMed Central

Ruby, E. G.; Greenberg, E. P.; Hastings, J. W.

1980-01-01

Luminous bacteria were isolated from oceanic water samples taken throughout the upper 1,000 m and ranged in density from 0.4 to 30 colony-forming units per 100 ml. Generally, two peaks in abundance were detected: one in the upper 100 m of the water column, which consisted primarily of Beneckea spp.; and a second between 250 and 1,000 m, which consisted almost entirely of Photobacterium phosphoreum. The population of P. phosphoreum remained relatively stable in abundance at one station that was visited three times over a period of 6 months. However, the abundance of luminous Beneckea spp. isolated from the upper waters fluctuated considerably; they were, as high as 30 colony-forming units per 100 ml in the spring and were not detected in the winter. Water samples from depths of 4,000 to 7,000 m contained less than 0.1 luminous colony-forming unit per 100 ml. The apparent vertical stratification of two taxa of oceanic luminous bacteria may reflect not only differences in physiology, but also depth-related, species-specific symbiotic associations. PMID:16345502

Concepts for the Design of a Diagnostic Device to Detect Malignancies in Human Tissues Final Report CRADA No. TSB-2023-00

DOE Office of Scientific and Technical Information (OSTI.GOV)

DaSilva, L.; Marion, J.; Chase, C.

BioLuminate, Inc. planned to develop, produce and market a revolutionary diagnostic device for early breast cancer diagnosis. The device was originally invented by NASA; and exclusively licensed to BioLuminate for commercialization. At the time of the CRADA, eighty-five percent (85%) of all biopsies in the United States were found negative each year. The number of biopsies cost the health care system $23 billio n annually. A multi-sensor probe would allow surgeons to improve breast cancer scre ening and significantly reduce the number of biopsies. BioLuminate was developing an in-vivo system for the detection of cancer using a multi-sensor needle/probe. Themore » first system would be developed for the detection of breast cancer. LLNL, in collaboration with BioLuminate worked toward a detailed concept specification for the prototype multi-sensor needle/probe suitable for breast cancer analysis. BioLuminate in collaboration with LLNL, worked to develop a new version of the needle probe that would be the same size as needles commonly used to draw blood.« less

Sub-luminous type Ia supernovae from the mergers of equal-mass white dwarfs with mass approximately 0.9M[symbol: see text].

PubMed

Pakmor, Rüdiger; Kromer, Markus; Röpke, Friedrich K; Sim, Stuart A; Ruiter, Ashley J; Hillebrandt, Wolfgang

2010-01-07

Type Ia supernovae are thought to result from thermonuclear explosions of carbon-oxygen white dwarf stars. Existing models generally explain the observed properties, with the exception of the sub-luminous 1991bg-like supernovae. It has long been suspected that the merger of two white dwarfs could give rise to a type Ia event, but hitherto simulations have failed to produce an explosion. Here we report a simulation of the merger of two equal-mass white dwarfs that leads to a sub-luminous explosion, although at the expense of requiring a single common-envelope phase, and component masses of approximately 0.9M[symbol: see text]. The light curve is too broad, but the synthesized spectra, red colour and low expansion velocities are all close to what is observed for sub-luminous 1991bg-like events. Although the mass ratios can be slightly less than one and still produce a sub-luminous event, the masses have to be in the range 0.83M[symbol: see text] to 0.9M[symbol: see text].

Super-Eight: The brightest z~8 Galaxies

NASA Astrophysics Data System (ADS)

Holwerda, Benne; Bouwens, R.; Bradley, L.; Calvi, V.; Illingworth, G.; Labbe, I.; Magee, D.; Oesch, P.; Roberts-Borsani, G.; Smit, R.

2016-08-01

What are the properties of the most massive z~8 galaxies ('Super-Eights') and how luminous can these galaxies become at that epoch? Answering these questions is challenging due to the rarity of luminous z~8 galaxies and the large field-to-field variations in their volume densities. Indeed, the full wide-area CANDELS program only shows 3 z~8 galaxy candidates brighter than 25.5 mag and all of these candidates conspicuously lie in the same CANDELS field (EGS). One of our strongest new probes for particularly luminous z~8 galaxies are the WFC3 Pure-Parallel (PP) programs. Particularly intriguing are 8 bright z~8 candidates in these observations. These candidates have similar luminosities as the 3 brightest z~8 candidates from CANDELS (all spectroscopically confirmed). However, the uncertain contamination levels at extreme bright end of z~8 selection mean that follow-up observations are critical. We propose highly-efficient pointed HST and Spitzer/IRAC observations to determine if these candidates are indeed at z~8. We estimate that anywhere from 50 to 100% of the targeted sources will be confirmed to be at z~8 based on our results from CANDELS. The estimate is very uncertain due to very large cosmic variance in the CANDELS result and contamination from rare low-redshift sources. When combined with CANDELS, our observations would provide us the strongest current constraints on the volume density of bright, massive galaxies in the early Universe (serving as a guide to models of their build-up) and also provide valuable targets for future spectroscopy (e.g. with JWST), useful for probing the ionization state of the IGM.

Super-Eight: The brightest z 8 Galaxies

NASA Astrophysics Data System (ADS)

Holwerda, Benne

2016-10-01

What are the properties of the most massive z 8 galaxies (Super-Eights) and how luminous can these galaxies become at that epoch? Answering these questions is challenging due to the rarity of luminous z 8 galaxies and the large field-to-field variations in their volume densities. Indeed, the full wide-area CANDELS program only shows 3 z 8 galaxy candidates brighter than 25.5 mag and all of these candidates conspicuously lie in the same CANDELS field (EGS). One of our strongest new probes for particularly luminous z 8 galaxies are the WFC3 Pure-Parallel (PP) programs. Particularly intriguing are 8 bright z 8 candidates in these observations. These candidates have similar luminosities as the 3 brightest z 8 candidates from CANDELS (all spectroscopically confirmed). However, the uncertain contamination levels at extreme bright end of z 8 selection mean that follow-up observations are critical. We propose highly-efficient pointed HST and Spitzer/IRAC observations to determine if these candidates are indeed at z 8. We estimate that anywhere from 50 to 100% of the targeted sources will be confirmed to be at z 8 based on our results from CANDELS. The estimate is very uncertain due to very large cosmic variance in the CANDELS result and contamination from rare low-redshift sources.When combined with CANDELS, our observations would provide us the strongest current constraints on the volume density of bright, massive galaxies in the early Universe (serving as a guide to models of their build-up) and also provide valuable targets for future spectroscopy (e.g. with JWST), useful for probing the ionization state of the IGM.

Different target-discrimination times can be followed by the same saccade-initiation timing in different stimulus conditions during visual searches

PubMed Central

Tanaka, Tomohiro; Nishida, Satoshi

2015-01-01

The neuronal processes that underlie visual searches can be divided into two stages: target discrimination and saccade preparation/generation. This predicts that the length of time of the prediscrimination stage varies according to the search difficulty across different stimulus conditions, whereas the length of the latter postdiscrimination stage is stimulus invariant. However, recent studies have suggested that the length of the postdiscrimination interval changes with different stimulus conditions. To address whether and how the visual stimulus affects determination of the postdiscrimination interval, we recorded single-neuron activity in the lateral intraparietal area (LIP) when monkeys (Macaca fuscata) performed a color-singleton search involving four stimulus conditions that differed regarding luminance (Bright vs. Dim) and target-distractor color similarity (Easy vs. Difficult). We specifically focused on comparing activities between the Bright-Difficult and Dim-Easy conditions, in which the visual stimuli were considerably different, but the mean reaction times were indistinguishable. This allowed us to examine the neuronal activity when the difference in the degree of search speed between different stimulus conditions was minimal. We found that not only prediscrimination but also postdiscrimination intervals varied across stimulus conditions: the postdiscrimination interval was longer in the Dim-Easy condition than in the Bright-Difficult condition. Further analysis revealed that the postdiscrimination interval might vary with stimulus luminance. A computer simulation using an accumulation-to-threshold model suggested that the luminance-related difference in visual response strength at discrimination time could be the cause of different postdiscrimination intervals. PMID:25995344

Characterizing visual asymmetries in contrast perception using shaded stimuli.

PubMed

Chacón, José; Castellanos, Miguel Ángel; Serrano-Pedraza, Ignacio

2015-01-01

Previous research has shown a visual asymmetry in shaded stimuli where the perceived contrast depended on the polarity of their dark and light areas (Chacón, 2004). In particular, circles filled out with a top-dark luminance ramp were perceived with higher contrast than top-light ones although both types of stimuli had the same physical contrast. Here, using shaded stimuli, we conducted four experiments in order to find out if the perceived contrast depends on: (a) the contrast level, (b) the type of shading (continuous vs. discrete) and its degree of perceived three-dimensionality, (c) the orientation of the shading, and (d) the sign of the perceived contrast alterations. In all experiments the observers' tasks were to equate the perceived contrast of two sets of elements (usually shaded with opposite luminance polarity), in order to determine the subjective equality point. Results showed that (a) there is a strong difference in perceived contrast between circles filled out with luminance ramp top-dark and top-light that is similar for different contrast levels; (b) we also found asymmetries in contrast perception with different shaded stimuli, and this asymmetry was not related with the perceived three-dimensionality but with the type of shading, being greater for continuous-shading stimuli; (c) differences in perceived contrast varied with stimulus orientation, showing the maximum difference on vertical axis with a left bias consistent with the bias found in previous studies that used visual-search tasks; and (d) asymmetries are consistent with an attenuation in perceived contrast that is selective for top-light vertically-shaded stimuli.

Efficient conceptual design for LED-based pixel light vehicle headlamps

NASA Astrophysics Data System (ADS)

Held, Marcel Philipp; Lachmayer, Roland

2017-12-01

High-resolution vehicle headlamps represent a future-oriented technology that can be used to increase traffic safety and driving comfort. As a further development to the current Matrix Beam headlamps, LED-based pixel light systems enable ideal lighting functions (e.g. projection of navigation information onto the road) to be activated in any given driving scenario. Moreover, compared to other light-modulating elements such as DMDs and LCDs, instantaneous LED on-off toggling provides a decisive advantage in efficiency. To generate highly individualized light distributions for automotive applications, a number of approaches using an LED array may be pursued. One approach is to vary the LED density in the array so as to output the desired light distribution. Another notable approach makes use of an equidistant arrangement of the individual LEDs together with distortion optics to formulate the desired light distribution. The optical system adjusts the light distribution in a manner that improves resolution and increases luminous intensity of the desired area. An efficient setup for pixel generation calls for one lens per LED. Taking into consideration the limited space requirements of the system, this implies that the luminous flux, efficiency and resolution image parameters are primarily controlled by the lens dimensions. In this paper a concept for an equidistant LED array arrangement utilizing distortion optics is presented. The paper is divided into two parts. The first part discusses the influence of lens geometry on the system efficiency whereas the second part investigates the correlation between resolution and luminous flux based on the lens dimensions.

Efficient calculation of luminance variation of a luminaire that uses LED light sources

NASA Astrophysics Data System (ADS)

Goldstein, Peter

2007-09-01

Many luminaires have an array of LEDs that illuminate a lenslet-array diffuser in order to create the appearance of a single, extended source with a smooth luminance distribution. Designing such a system is challenging because luminance calculations for a lenslet array generally involve tracing millions of rays per LED, which is computationally intensive and time-consuming. This paper presents a technique for calculating an on-axis luminance distribution by tracing only one ray per LED per lenslet. A multiple-LED system is simulated with this method, and with Monte Carlo ray-tracing software for comparison. Accuracy improves, and computation time decreases by at least five orders of magnitude with this technique, which has applications in LED-based signage, displays, and general illumination.

Accuracy of shade matching performed by colour blind and normal dental students using 3D Master and Vita Lumin shade guides.

PubMed

Vafaee, F; Rakhshan, V; Vafaei, M; Khoshhal, M

2012-03-01

The purpose of this study was to investigate whether 3D Master or VitaLumin shade guides could improve colour selection in individuals with normal and defective colour vision. First, colour perception of 260 dental students was evaluated. Afterwards, 9 colour blind and 9 matched normal subjects tried to detect colours of 10 randomly selected tabs from each kit and the correct/false answers were counted. Of the colour-defective subjects, 47.8% and 33.3% correctly detected the shade using 3D Master and VitaLumin, respectively. These statistics were 62.2% and 42.2% in normal subjects. In normal participants, but not in colour blind ones, 3D Master significantly improved shade matching accuracy compared to VitaLumin.

The X-Ray Lightcurve of Eta Carinae: Refinement of the Orbit and Evidence for Phase Dependent Mass Loss

NASA Technical Reports Server (NTRS)

Corcoran, M. F.; Ishibashi, K.; Swank, J. H.; Petre, R.; White, Nicholas E. (Technical Monitor)

2000-01-01

We solve the RXTE X-ray lightcurve of the extremely luminous and massive star eta Carinae with a colliding wind emission model to refine the ground-based orbital elements. The sharp decline to X-ray minimum at the end of 1997 fixes the date of the last periastron passage at 1997.95 +/- 0.05, not 1998.13 as derived from ground-based radial velocities. This helps resolve a discrepancy between the ground-based radial velocities and spatially-resolved velocity measures obtained by STIS. The X-ray data are consistent with a mass function f(M) approx. = 1.5, lower than the value f(M) approx. = 7.5 previously reported, so that the masses of eta Carinae and the companion are M(sub eta) greater than or = 80 solar mass and M(sub c) approx. 30 solar mass respectively. In addition the X-ray data suggest that the mass loss rate from eta Carinae is generally less than 3 x 10(exp -4) solar mass/yr, about a factor of 5 lower than that derived from some observations in other wavebands. We could not match the duration of the X-ray minimum with any standard colliding wind model in which the wind is spherically symmetric and the mass loss rate is constant. However we show that we can match the variations around X-ray minimum if we include an increase of a factor of approx. 20 in the mass loss rate from eta Carinae for approximately 80 days following periastron. If real, this excess in M would be the first evidence of enhanced mass flow off the primary when the two stars are close (presumably driven by tidal interactions). Our interpretation of the X-ray data suggest that the ASCA and RXTE X-ray spectra near the X-ray minimum are significantly contaminated by unresolved hard emission (E greater than or = 2 keV) from sonic other nearby source, probably associated with scattering of tile colliding wind emission by circumstellar dust. Based on the X-ray fluxes the distance to n Carinae is 2300 pc with formal uncertainties of only approx. 10%.

Line-profile and continuum variations of the contact binary SV Centauri

NASA Technical Reports Server (NTRS)

Rahe, J.; Drechsel, H.; Wargau, W.

1982-01-01

A total of five high and ten low dispersion UV spectra of the interacting contact binary SV Centauri obtained between 1979 and 1982 are analyzed. The low resolution observations cover the whole phase range, while a few selected phases were observed in high dispersion. The UV data were complemented with optical photometric and spectroscopic observations, in order to determine the tructure and absolute dimensions of the system. The profiles of prominent UV resonance and metastable lines undergo drastic changes with phase angle and time. Their overall appearance indicates relatively strong mass loss from the system, exhibiting pronounced variations of the stellar wind. The far UV continuum distribution suggests the presence of a luminous hot radiation source with maximum emission in the soft X-ray range, which is most apparently seen during the first quadrature phase, while it is weakest close to primary minimum. The case exchange and mass loss process as well as the evolutionary stage of SV Centauri are discussed.

Luminance sticker based facial expression recognition using discrete wavelet transform for physically disabled persons.

PubMed

Nagarajan, R; Hariharan, M; Satiyan, M

2012-08-01

Developing tools to assist physically disabled and immobilized people through facial expression is a challenging area of research and has attracted many researchers recently. In this paper, luminance stickers based facial expression recognition is proposed. Recognition of facial expression is carried out by employing Discrete Wavelet Transform (DWT) as a feature extraction method. Different wavelet families with their different orders (db1 to db20, Coif1 to Coif 5 and Sym2 to Sym8) are utilized to investigate their performance in recognizing facial expression and to evaluate their computational time. Standard deviation is computed for the coefficients of first level of wavelet decomposition for every order of wavelet family. This standard deviation is used to form a set of feature vectors for classification. In this study, conventional validation and cross validation are performed to evaluate the efficiency of the suggested feature vectors. Three different classifiers namely Artificial Neural Network (ANN), k-Nearest Neighborhood (kNN) and Linear Discriminant Analysis (LDA) are used to classify a set of eight facial expressions. The experimental results demonstrate that the proposed method gives very promising classification accuracies.

Method of Reproduction of the Luminous Flux of the LED Light Sources by a Spherical Photometer

NASA Astrophysics Data System (ADS)

Huriev, M.; Neyezhmakov, P.

2018-02-01

In connection with transition to energy-efficient temporally stable light-emitting diodes (LEDs) lighting, a problem of ensuring the traceability of results of measurement of characteristics of light sources arises. The problem is related to existing measurement standards of luminous flux based on spherical photometers optimized for the reference incandescent lamps with a relative spectral characteristic different from the spectrum of the LEDs. We propose a method for reproduction of the luminous flux, which solves this problem.

Probing the luminal microenvironment of reconstituted epithelial microtissues

PubMed Central

Cerchiari, Alec E.; Samy, Karen E.; Todhunter, Michael E.; Schlesinger, Erica; Henise, Jeff; Rieken, Christopher; Gartner, Zev J.; Desai, Tejal A.

2016-01-01

Polymeric microparticles can serve as carriers or sensors to instruct or characterize tissue biology. However, incorporating microparticles into tissues for in vitro assays remains a challenge. We exploit three-dimensional cell-patterning technologies and directed epithelial self-organization to deliver microparticles to the lumen of reconstituted human intestinal microtissues. We also develop a novel pH-sensitive microsensor that can measure the luminal pH of reconstituted epithelial microtissues. These studies offer a novel approach for investigating luminal microenvironments and drug-delivery across epithelial barriers. PMID:27619235

Advancing Our Understanding of the Etiologies and Mutational Landscapes of Basal Like, Luminal A, and Luminal B Breast Cancers

DTIC Science & Technology

2016-10-01

and luminal B tumors. Our original goal was to recruit about 2,700 women in Western Washington who have been diagnosed with breast cancer to compare...to 900 women who have never been diagnosed with breast cancer, but control ascertainment has been unacceptably low, so on 8/25/15 we submitted a...cases,1800 randomly selected age-matched estrogen receptor positive (ER+) cases, and for comparison, a population-based control group of 900 women

Scaling-up the minimum requirements analysis for big wilderness issues

Treesearch

David N. Cole

2007-01-01

The concept of applying a "minimum requirements" analysis to decisions about administrative actions in wilderness in the United States has been around for a long time. It comes from Section 4(c) of the Wilderness Act of 1964, which states that "except as necessary to meet minimum requirements for the administration of the area for the purposes of this...

Relationship between luminous fish and symbiosis. I. Comparative studies of lipopolysaccharides isolated from symbiotic luminous bacteria of the luminous marine fish, Physiculus japonicus.

PubMed

Kuwae, T; Andoh, M; Fukasawa, S; Kurata, M

1983-01-01

In order to investigate the relationship between host and symbiosis in the luminous marine fish, Physiculus japonicus, the bacterial lipopolysaccharides (LPS) of symbiotic luminous bacteria were compared serologically and electrophoretically. Five symbiotic luminous bacteria (PJ strains) were separately isolated from five individuals of this fish species caught at three points, off the coasts of Chiba, Nakaminato, and Oharai. LPS preparations were made from these bacteria by Westphal's phenol-water method and highly purified by repeated ultracentrifugation. These LPSs contained little or no 2-keto-3-deoxyoctonate and had powerful mitogenic activity. In sodium dodecylsulfate polyacrylamide gel electrophoresis, these PJ-1 to -5 LPSs were separated by their electrophoretic patterns into three groups; the first group included PJ-1 and PJ-4, the second group PJ-2 and PJ-3, and the third group PJ-5 alone. The results agreed with those of the double immunodiffusion test; precipitin lines completely coalesced within each group but not with other groups. In immunoelectrophoresis, one precipitin line was observed between anti PJ-2 LPS serum and PJ-5 LPS but the electrophoretic mobility of PJ-5 LPS was clearly different from that of the PJ-2 LPS group. Furthermore, in a 50% inhibition test with PJ-2 LPS by the passive hemolysis system, the doses of PJ-2 LPS, PJ-3 LPS, and PJ-5 LPS required for 50% inhibition (ID50) in this system were 0.25, 0.25, and 21.6 micrograms/ml for each alkali-treated LPS, respectively, and the ID50's of both PJ-1 LPS and PJ-4 LPS were above 1,000 micrograms/ml. These results indicate that PJ-5 LPS has an antigenic determinant partially in common with LPS from the PJ-2 group but not with LPS from the PJ-1 group and that the symbiotic luminous bacterium PJ-5 is more closely related to the PJ-2 group than to the PJ-1 group. These results show that the species Physiculus japonicus is symbiotically associated with at least three immunologically different strains of luminous marine bacteria in its specialized light organ.

Predictive and Prognostic Brain Metastases Assessment in Luminal Breast Cancer Patients: FN14 and GRP94 from Diagnosis to Prophylaxis

PubMed Central

Martínez-Aranda, Antonio; Hernández, Vanessa; Moreno, Ferran; Baixeras, Núria; Cuadras, Daniel; Urruticoechea, Ander; Gil-Gil, Miguel; Vidal, Noemí; Andreu, Xavier; Seguí, Miquel A.; Ballester, Rosa; Castella, Eva; Sierra, Angels

2017-01-01

FN14 has been implicated in many intracellular signaling pathways, and GRP94 is a well-known endoplasmic reticulum protein regulated by glucose. Recently, both have been associated with metastasis progression in breast cancer patients. We studied the usefulness of FN14 and GRP94 expression to stratify breast cancer patients according their risk of brain metastasis (BrM) progression. We analyzed FN14 and GRP94 by immunohistochemistry in a retrospective multicenter study using tissue microarrays from 208 patients with breast carcinomas, of whom 52 had developed BrM. Clinical and pathological characteristics and biomarkers expression in Luminal and non-Luminal patients were analyzed using a multivariate logistic regression model adjusted for covariates, and brain metastasis-free survival (BrMFS) was estimated using the Kaplan–Meier method and the Cox proportional hazards model. FN14 expression was associated with BrM progression mainly in Luminal breast cancer patients with a sensitivity (53.85%) and specificity (89.60%) similar to Her2 expression (46.15 and 89.84%, respectively). Moreover, the likelihood to develop BrM in FN14-positive Luminal carcinomas increased 36.70-fold (3.65–368.25, p = 0.002). Furthermore, the worst prognostic factor for BrMFS in patients with Luminal carcinomas was FN14 overexpression (HR = 8.25; 95% CI: 2.77–24.61; p = 0.00015). In these patients, GRP94 overexpression also increased the risk of BrM (HR = 3.58; 95% CI: 0.98–13.11; p = 0.054—Wald test). Therefore, FN14 expression in Luminal breast carcinomas is a predictive/prognostic biomarker of BrM, which combined with GRP94 predicts BrM progression in non-Luminal tumors 4.04-fold (1.19–8.22, p = 0.025), suggesting that both biomarkers are useful to stratify BrM risk at early diagnosis. We propose a new follow-up protocol for the early prevention of clinical BrM of breast cancer patients with BrM risk. PMID:29250484

MCM2: An alternative to Ki-67 for measuring breast cancer cell proliferation.

PubMed

Yousef, Einas M; Furrer, Daniela; Laperriere, David L; Tahir, Muhammad R; Mader, Sylvie; Diorio, Caroline; Gaboury, Louis A

2017-05-01

Breast cancer is a heterogeneous disease comprising a diversity of tumor subtypes that manifest themselves in a wide variety of clinical, pathological, and molecular features. One important subset, luminal breast cancers, comprises two clinically distinct subtypes luminal A and B each of them endowed with its own genetic program of differentiation and proliferation. Luminal breast cancers were operationally defined as follows: Luminal A: ER+, PR+, HER2-, Ki-67<14% and Luminal B: ER+ and/or PR+, HER2-,Ki-67≥14% or, alternatively ER+ and/or PR+, HER2+, any Ki-67. There is currently a need for a clinically robust and validated immunohistochemical assay that can help distinguish between luminal A and B breast cancer. MCM2 is a family member of the minichromosome maintenance protein complex whose role in DNA replication and cell proliferation is firmly established. As MCM2 appears to be an attractive alternative to Ki-67, we sought to study the expression of MCM2 and Ki-67 in different histological grades and molecular subtypes of breast cancer focusing primarily on ER-positive tumors. MCM2 and Ki-67 mRNA expression were studied using in silico analysis of available DNA microarray and RNA-sequencing data of human breast cancer. We next used immunohistochemistry to evaluate protein expression of MCM2 and Ki-67 on tissue microarrays of invasive breast carcinoma. We found that MCM2 and Ki-67 are highly expressed in breast tumors of high histological grades, comprising clinically aggressive tumors such as triple-negative, HER2-positive and luminal B subtypes. MCM2 expression was detected at higher levels than that of Ki-67 in normal breast tissues and in breast cancers. The bimodal distribution of MCM2 scores in ER+/HER2- breast tumors led to the identification of two distinct subgroups with different relapse-free survival rates. In conclusion, MCM2 expression can help sorting out two clinically important subsets of luminal breast cancer whose treatment and clinical outcomes are likely to diverge.

Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum

PubMed Central

Inoue, Takuya; Wang, Joon-Ho; Higashiyama, Masaaki; Rudenkyy, Sergiy; Higuchi, Kazuhide; Guth, Paul H.; Engel, Eli; Kaunitz, Jonathan D.

2012-01-01

Intestinal endocrine cells release gut hormones, including glucagon-like peptides (GLPs), in response to luminal nutrients. Luminal l-glutamate (l-Glu) and 5′-inosine monophosphate (IMP) synergistically increases duodenal HCO3− secretion via GLP-2 release. Since L cells express the bile acid receptor TGR5 and dipeptidyl peptidase (DPP) IV rapidly degrades GLPs, we hypothesized that luminal amino acids or bile acids stimulate duodenal HCO3− secretion via GLP-2 release, which is enhanced by DPPIV inhibition. We measured HCO3− secretion with pH and CO2 electrodes using a perfused rat duodenal loop under isoflurane anesthesia. l-Glu (10 mM) and IMP (0.1 mM) were luminally coperfused with or without luminal perfusion (0.1 mM) or intravenous (iv) injection (3 μmol/kg) of the DPPIV inhibitor NVP728. The loop was also perfused with a selective TGR5 agonist betulinic acid (BTA, 10 μM) or the non-bile acid type TGR5 agonist 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide (CCDC; 10 μM). DPPIV activity visualized by use of the fluorogenic substrate was present on the duodenal brush border and submucosal layer, both abolished by the incubation with NVP728 (0.1 mM). An iv injection of NVP728 enhanced l-Glu/IMP-induced HCO3− secretion, whereas luminal perfusion of NVP728 had no effect. BTA or CCDC had little effect on HCO3− secretion, whereas NVP728 iv markedly enhanced BTA- or CCDC-induced HCO3− secretion, the effects inhibited by a GLP-2 receptor antagonist. Coperfusion of the TGR5 agonist enhanced l-Glu/IMP-induced HCO3− secretion with the enhanced GLP-2 release, suggesting that TGR5 activation amplifies nutrient sensing signals. DPPIV inhibition potentiated luminal l-Glu/IMP-induced and TGR5 agonist-induced HCO3− secretion via a GLP-2 pathway, suggesting that the modulation of the local concentration of the endogenous secretagogue GLP-2 by luminal compounds and DPPIV inhibition helps regulate protective duodenal HCO3− secretion. PMID:22821947

Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum.

PubMed

Inoue, Takuya; Wang, Joon-Ho; Higashiyama, Masaaki; Rudenkyy, Sergiy; Higuchi, Kazuhide; Guth, Paul H; Engel, Eli; Kaunitz, Jonathan D; Akiba, Yasutada

2012-10-01

Intestinal endocrine cells release gut hormones, including glucagon-like peptides (GLPs), in response to luminal nutrients. Luminal L-glutamate (L-Glu) and 5'-inosine monophosphate (IMP) synergistically increases duodenal HCO3- secretion via GLP-2 release. Since L cells express the bile acid receptor TGR5 and dipeptidyl peptidase (DPP) IV rapidly degrades GLPs, we hypothesized that luminal amino acids or bile acids stimulate duodenal HCO3- secretion via GLP-2 release, which is enhanced by DPPIV inhibition. We measured HCO3- secretion with pH and CO2 electrodes using a perfused rat duodenal loop under isoflurane anesthesia. L-Glu (10 mM) and IMP (0.1 mM) were luminally coperfused with or without luminal perfusion (0.1 mM) or intravenous (iv) injection (3 μmol/kg) of the DPPIV inhibitor NVP728. The loop was also perfused with a selective TGR5 agonist betulinic acid (BTA, 10 μM) or the non-bile acid type TGR5 agonist 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide (CCDC; 10 μM). DPPIV activity visualized by use of the fluorogenic substrate was present on the duodenal brush border and submucosal layer, both abolished by the incubation with NVP728 (0.1 mM). An iv injection of NVP728 enhanced L-Glu/IMP-induced HCO3- secretion, whereas luminal perfusion of NVP728 had no effect. BTA or CCDC had little effect on HCO3- secretion, whereas NVP728 iv markedly enhanced BTA- or CCDC-induced HCO3- secretion, the effects inhibited by a GLP-2 receptor antagonist. Coperfusion of the TGR5 agonist enhanced L-Glu/IMP-induced HCO3- secretion with the enhanced GLP-2 release, suggesting that TGR5 activation amplifies nutrient sensing signals. DPPIV inhibition potentiated luminal L-Glu/IMP-induced and TGR5 agonist-induced HCO3- secretion via a GLP-2 pathway, suggesting that the modulation of the local concentration of the endogenous secretagogue GLP-2 by luminal compounds and DPPIV inhibition helps regulate protective duodenal HCO3- secretion.

Plasma plume expansion dynamics in nanosecond Nd:YAG laserosteotome

NASA Astrophysics Data System (ADS)

Abbasi, Hamed; Rauter, Georg; Guzman, Raphael; Cattin, Philippe C.; Zam, Azhar

2018-02-01

In minimal invasive laser osteotomy precise information about the ablation process can be obtained with LIBS in order to avoid carbonization, or cutting of wrong types of tissue. Therefore, the collecting fiber for LIBS needs to be optimally placed in narrow cavities in the endoscope. To determine this optimal placement, the plasma plume expansion dynamics in ablation of bone tissue by the second harmonic of a nanosecond Nd:YAG laser at 532 nm has been studied. The laserinduced plasma plume was monitored in different time delays, from one nanosecond up to one hundred microseconds. Measurements were performed using high-speed gated illumination imaging. The expansion features were studied using illumination of the overall visible emission by using a gated intensified charged coupled device (ICCD). The camera was capable of having a minimum gate width (Optical FWHM) of 3 ns and the timing resolution (minimum temporal shift of the gate) of 10 ps. The imaging data were used to generate position-time data of the luminous plasma-front. Moreover, the velocity of the plasma plume expansion was studied based on the time-resolved intensity data. By knowing the plasma plume profile over time, the optimum position (axial distance from the laser spot) of the collecting fiber and optimal time delay (to have the best signal to noise ratio) in spatial-resolved and time-resolved laser-induced breakdown spectroscopy (LIBS) can be determined. Additionally, the function of plasma plume expansion could be used to study the shock wave of the plasma plume.

24 CFR 200.925a - Multifamily and care-type minimum property standards.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Minimum Property..., electrical, and elevators. (3) For purposes of this paragraph, a state or local code regulates an area if it...

Moon Illusion: An Event in Imaginary Space.

PubMed

Gruber, H E; King, W L; Link, S

1963-02-22

The illusion was obtained with artificial moons viewed against a luminous ceiling, and also with an imaginary ceiling induced by first showing a luminous ceiling and then removing it before the moons were introduced.

Adenosine uptake by the isolated epithelium of guine pig jejunum.

PubMed

Kolassa, N; Stengg, R; Turnheim, K

1977-10-01

The uptake of [8-14C]adenosine by the isolated epithelium of guinea pig jejunum was faster than that of inosine, hypoxanthine, or adenine. The initial velocity of adenosine uptake from both the luminal and the antiluminal side of the epithelium exhibited saturation kinetics. The apparent Km, V, and passive permeability of luminal adenosine uptake were all lower than the corresponding values of antiluminal uptake. p-Nitrobenzyl-thioguanosine inhibited adenosine uptake from both the luminal and the antiluminal side, whilst hexobendine decreased the uptake only from the antiluminal side of the epithelium. The results suggest that adenosine enters the intestinal epithelium by a carrier-mediated process in addition to passive diffusion. The antiluminal transport system for adenosine seems similar to that of other tissues with respect to hexobendine inhibition; the luminal transport mechanism, however, exhibits different properties, being insensitive to hexobendine.

Measurements of UGR of LED light by a DSLR colorimeter

NASA Astrophysics Data System (ADS)

Hsu, Shau-Wei; Chen, Cheng-Hsien; Jiaan, Yuh-Der

2012-10-01

We have developed an image-based measurement method on UGR (unified glare rating) of interior lighting environment. A calibrated DSLR (digital single-lens reflex camera) with an ultra wide-angle lens was used to measure the luminance distribution, by which the corresponding parameters can be automatically calculated. A LED lighting was placed in a room and measured at various positions and directions to study the properties of UGR. The testing results are fitted with visual experiences and UGR principles. To further examine the results, a spectroradiometer and an illuminance meter were respectively used to measure the luminance and illuminance at the same position and orientation of the DSLR. The calculation of UGR by this image-based method may solve the problem of non-uniform luminance-distribution of LED lighting, and was studied on segmentation of the luminance graph for the calculations.

Human factors studies of control configurations for advanced transport aircraft

NASA Technical Reports Server (NTRS)

Snyder, Harry L.; Monty, Robert W.; Old, Joe

1985-01-01

This research investigated the threshold levels of display luminance contrast which were required to interpret static, achromatic, integrated displays of primary flight information. A four-factor within-subjects design was used to investigate the influences of type of flight variable information, the level of ambient illumination, the type of control input, and the size of the display symbology on the setting of these interpretability thresholds. A three-alternative forced choice paradigm was used in conjunction with the method of adjustments to obtain a measure of the upper limen of display luminance contrast needed to interpret a complex display of primary flight information. The pattern of results and the absolute magnitudes of the luminance contrast settings were found to be in good agreement with previously reported data from psychophysical investigations of display luminance contrast requirements.

Optimal front light design for reflective displays under different ambient illumination

NASA Astrophysics Data System (ADS)

Wang, Sheng-Po; Chang, Ting-Ting; Li, Chien-Ju; Bai, Yi-Ho; Hu, Kuo-Jui

2011-01-01

The goal of this study is to find out the optimal luminance and color temperature of front light for reflective displays in different ambient illumination by conducting series of psychophysical experiments. A color and brightness tunable front light device with ten LED units was built and been calibrated to present 256 luminance levels and 13 different color temperature at fixed luminance of 200 cd/m2. The experiment results revealed the best luminance and color temperature settings for human observers under different ambient illuminant, which could also assist the e-paper manufacturers to design front light device, and present the best image quality on reflective displays. Furthermore, a similar experiment procedure was conducted by utilizing new flexible e-signage display developed by ITRI and an optimal front light device for the new display panel has been designed and utilized.

Laser-activated remote phosphor light engine for projection applications

NASA Astrophysics Data System (ADS)

Daniels, Martin; Mehl, Oliver; Hartwig, Ulrich

2015-09-01

Recent developments in blue emitting laser diodes enable attractive solutions in projection applications using phosphors for efficient light conversion with very high luminance levels. Various commercially available projectors incorporating this technology have entered the market in the past years. While luminous flux levels are still comparable to lamp-based systems, lifetime expectations of classical lamp systems are exceeded by far. OSRAM GmbH has been exploring this technology for several years and has introduced the PHASER® brand name (Phosphor + laser). State-of-the-art is a rotating phosphor wheel excited by blue laser diodes to deliver the necessary primary colors, either sequentially for single-imager projection engines, or simultaneously for 3-panel systems. The PHASER® technology enables flux and luminance scaling, which allows for smaller imagers and therefore cost-efficient projection solutions. The resulting overall efficiency and ANSI lumen specification at the projection screen of these systems is significantly determined by the target color gamut and the light transmission efficiency of the projection system. With increasing power and flux level demand, thermal issues, especially phosphor conversion related, dominate the opto-mechanical system design requirements. These flux levels are a great challenge for all components of an SSL-projection system (SSL:solid-state lighting). OSRAḾs PHASER® light engine platform is constantly expanded towards higher luminous flux levels as well as higher luminance levels for various applications. Recent experiments employ blue laser pump powers of multiple 100 Watts to excite various phosphors resulting in luminous flux levels of more than 40 klm.

Glossiness and perishable food quality: visual freshness judgment of fish eyes based on luminance distribution.

PubMed

Murakoshi, Takuma; Masuda, Tomohiro; Utsumi, Ken; Tsubota, Kazuo; Wada, Yuji

2013-01-01

Previous studies have reported the effects of statistics of luminance distribution on visual freshness perception using pictures which included the degradation process of food samples. However, these studies did not examine the effect of individual differences between the same kinds of food. Here we elucidate whether luminance distribution would continue to have a significant effect on visual freshness perception even if visual stimuli included individual differences in addition to the degradation process of foods. We took pictures of the degradation of three fishes over 3.29 hours in a controlled environment, then cropped square patches of their eyes from the original images as visual stimuli. Eleven participants performed paired comparison tests judging the visual freshness of the fish eyes at three points of degradation. Perceived freshness scores (PFS) were calculated using the Bradley-Terry Model for each image. The ANOVA revealed that the PFS for each fish decreased as the degradation time increased; however, the differences in the PFS between individual fish was larger for the shorter degradation time, and smaller for the longer degradation time. A multiple linear regression analysis was conducted in order to determine the relative importance of the statistics of luminance distribution of the stimulus images in predicting PFS. The results show that standard deviation and skewness in luminance distribution have a significant influence on PFS. These results show that even if foodstuffs contain individual differences, visual freshness perception and changes in luminance distribution correlate with degradation time.

Texture variations suppress suprathreshold brightness and colour variations.

PubMed

Schofield, Andrew J; Kingdom, Frederick A A

2014-01-01

Discriminating material changes from illumination changes is a key function of early vision. Luminance cues are ambiguous in this regard, but can be disambiguated by co-incident changes in colour and texture. Thus, colour and texture are likely to be given greater prominence than luminance for object segmentation, and better segmentation should in turn produce stronger grouping. We sought to measure the relative strengths of combined luminance, colour and texture contrast using a suprathreshhold, psychophysical grouping task. Stimuli comprised diagonal grids of circular patches bordered by a thin black line and contained combinations of luminance decrements with either violet, red, or texture increments. There were two tasks. In the Separate task the different cues were presented separately in a two-interval design, and participants indicated which interval contained the stronger orientation structure. In the Combined task the cues were combined to produce competing orientation structure in a single image. Participants had to indicate which orientation, and therefore which cue was dominant. Thus we established the relative grouping strength of each cue pair presented separately, and compared this to their relative grouping strength when combined. In this way we observed suprathreshold interactions between cues and were able to assess cue dominance at ecologically relevant signal levels. Participants required significantly more luminance and colour compared to texture contrast in the Combined compared to Separate conditions (contrast ratios differed by about 0.1 log units), showing that suprathreshold texture dominates colour and luminance when the different cues are presented in combination.

Unique Color Converter Architecture Enabling Phosphor-in-Glass (PiG) Films Suitable for High-Power and High-Luminance Laser-Driven White Lighting.

PubMed

Zheng, Peng; Li, Shuxing; Wang, Le; Zhou, Tian-Liang; You, Shihai; Takeda, Takashi; Hirosaki, Naoto; Xie, Rong-Jun

2018-05-02

As a next-generation high-power lighting technology, laser lighting has attracted great attention in high-luminance applications. However, thermally robust and highly efficient color converters suitable for high-quality laser lighting are scarce. Despite its versatility, the phosphor-in-glass (PiG) has been seldom applied in laser lighting because of its low thermal conductivity. In this work, we develop a unique architecture in which a phosphor-in-glass (PiG) film was directly sintered on a high thermally conductive sapphire substrate coated by one-dimensional photonic crystals. The designed color converter with the composite architecture exhibits a high internal quantum efficiency close to that of the original phosphor powders and an excellent packaging efficiency up to 90%. Furthermore, the PiG film can even be survived under the 11.2 W mm -2 blue laser excitation. Combining blue laser diodes with the YAG-PiG-on-sapphire plate, a uniform white light with a high luminance of 845 Mcd m -2 (luminous flux: 1839 lm), luminous efficacy of 210 lm W -1 , and correlated color temperature of 6504 K was obtained. A high color rendering index of 74 was attained by adding a robust orange or red phosphor layer to the architecture. These outstanding properties meet the standards of vehicle regulations, enabling the PiG films with the composite architecture to be applied in automotive lighting or other high-power and high-luminance laser lighting.

Breaking object correspondence across saccades impairs object recognition: The role of color and luminance.

PubMed

Poth, Christian H; Schneider, Werner X

2016-09-01

Rapid saccadic eye movements bring the foveal region of the eye's retina onto objects for high-acuity vision. Saccades change the location and resolution of objects' retinal images. To perceive objects as visually stable across saccades, correspondence between the objects before and after the saccade must be established. We have previously shown that breaking object correspondence across the saccade causes a decrement in object recognition (Poth, Herwig, & Schneider, 2015). Color and luminance can establish object correspondence, but it is unknown how these surface features contribute to transsaccadic visual processing. Here, we investigated whether changing the surface features color-and-luminance and color alone across saccades impairs postsaccadic object recognition. Participants made saccades to peripheral objects, which either maintained or changed their surface features across the saccade. After the saccade, participants briefly viewed a letter within the saccade target object (terminated by a pattern mask). Postsaccadic object recognition was assessed as participants' accuracy in reporting the letter. Experiment A used the colors green and red with different luminances as surface features, Experiment B blue and yellow with approximately the same luminances. Changing the surface features across the saccade deteriorated postsaccadic object recognition in both experiments. These findings reveal a link between object recognition and object correspondence relying on the surface features colors and luminance, which is currently not addressed in theories of transsaccadic perception. We interpret the findings within a recent theory ascribing this link to visual attention (Schneider, 2013).

Visceral Crisis Means Short Survival Among Patients With Luminal A Metastatic Breast Cancer: A Retrospective Cohort Study.

PubMed

Sbitti, Yassir; Slimani, Khaoula; Debbagh, Adil; Mokhlis, Anouar; Kadiri, Habiba; Laraqui, Abdelilah; Errihani, Hassan; Ichou, Mohamed

2017-08-01

Patients with visceral crisis from luminal metastatic breast cancer (mBC) are often treated with palliative chemotherapy. No studies have analyzed the aggressiveness of the care in visceral crisis from luminal mBC patients. The objective of this study was to assess practices in this setting in a university medical oncology department. This retrospective study included all patients who were managed for luminal mBC between January 2013 and April 2016. The analysis focused on the characteristics of the patients, the modalities of cancer treatment and delays between visceral crisis and death. Thirty-five patients pre-treated with two hormonal therapy lines were enrolled retrospectively. Worse performance status and a higher proportion of severe organ dysfunction for luminal mBC were observed among patients with visceral crisis. Sixty-five percent of patients received cytotoxic treatment. One cycle of chemotherapy was administrated in the majority of patients. Palliative care was performed in 35% of patients. Chemotherapy did not have any significant effect on patient outcome in the present study. The mean time between visceral crisis and death was 4.7 weeks (standard deviation = 1.9). Our study showed that visceral crisis in patients with luminal mBC is a complex problem. We need more comprehension of molecular pathogenesis to visceral crisis disease to propose efficacious treatments for these patients and to identify subgroup of patients who need chemotherapy followed by maintenance endocrine therapy.

Somatic mutations in early onset luminal breast cancer

PubMed Central

de Lyra, Eduardo Carneiro; Hirata Katayama, Maria Lucia; Maistro, Simone; de Vasconcellos Valle, Pedro Wilson Mompean; de Lima Pereira, Gláucia Fernanda; Rodrigues, Lívia Munhoz; de Menezes Pacheco Serio, Pedro Adolpho; de Gouvêa, Ana Carolina Ribeiro Chaves; Geyer, Felipe Correa; Basso, Ricardo Alves; Pasini, Fátima Solange; del Pilar Esteves Diz, Maria; Brentani, Maria Mitzi; Guedes Sampaio Góes, João Carlos; Chammas, Roger; Boutros, Paul C.; Koike Folgueira, Maria Aparecida Azevedo

2018-01-01

Breast cancer arising in very young patients may be biologically distinct; however, these tumors have been less well studied. We characterized a group of very young patients (≤ 35 years) for BRCA germline mutation and for somatic mutations in luminal (HER2 negative) breast cancer. Thirteen of 79 unselected very young patients were BRCA1/2 germline mutation carriers. Of the non-BRCA tumors, eight with luminal subtype (HER2 negative) were submitted for whole exome sequencing and integrated with 29 luminal samples from the COSMIC database or previous literature for analysis. We identified C to T single nucleotide variants (SNVs) as the most common base-change. A median of six candidate driver genes was mutated by SNVs in each sample and the most frequently mutated genes were PIK3CA, GATA3, TP53 and MAP2K4. Potential cancer drivers affected in the present non-BRCA tumors include GRHL2, PIK3AP1, CACNA1E, SEMA6D, SMURF2, RSBN1 and MTHFD2. Sixteen out of 37 luminal tumors (43%) harbored SNVs in DNA repair genes, such as ATR, BAP1, ERCC6, FANCD2, FANCL, MLH1, MUTYH, PALB2, POLD1, POLE, RAD9A, RAD51 and TP53, and 54% presented pathogenic mutations (frameshift or nonsense) in at least one gene involved in gene transcription. The differential biology of luminal early-age onset breast cancer needs a deeper genomic investigation. PMID:29854292

[Prevalence of breast cancer sub-types by immunohistochemistry in patients in the Regional General Hospital 72, Instituto Mexicano del Seguro Social].

PubMed

Pérez-Rodríguez, Gabriel

2015-01-01

Breast cancer mortality has increased in women 25 years and over, and since 2006 it has surpassed cervical cancer. Breast cancer is a heterogeneous disease, with several clinical and histological presentations that require a thorough study of all clinical and pathological parameters, including immunohistochemistry to classify it into subtypes, have a better prognosis, provide individualised treatment, increase survival, and reduce mortality. To evaluate the prevalence of sub-types of breast cancer and the association with the clinical and histopathological features of the tumour. An observational, retrospective, cross-sectional and analytical study conducted on 1380 patients with a diagnosis of breast cancer have been classified by immunohistochemistry into four subtypes: luminal A, triple negative, luminal B and HER2. An analysis was performed on the association with age, risk factors, and the clinical and histopathological features of the tumour. The mean age of the patients was 53.3 ± 11.4. The frequency was luminal A (65%), triple negative (14%), luminal B (12%), and HER2 (9%). The most frequent characteristics were the 50 to 59 age range, late menopause, the right side, upper external quadrant, stage II, metastatic lymph nodes, and mastectomy. The most frequent sub-type was luminal A, and together with the luminal B are those which have better prognosis compared with the triple negative and HER2. Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.

Simultaneous image reproduction on CRT screen: Moves ultrasonic sectional view and electrocardiogram curves

NASA Technical Reports Server (NTRS)

1978-01-01

A method for simultaneous reproduction of images, requiring different amounts of time to reproduce, on a cathode ray tube (CRT) screen is disclosed. Ultrasonic sectional views and electrocardiogram curves are simultaneously reproduced on the CRT screen by producing the images on different areas of a screen with two phosphors having different persistence times and luminous colors, within the times required for the appearance of the images. In front of the area on which is produced the image requiring the shorter time is a color filter which is permeable to the color of the phosphor with the shorter persistence time by which absorbs the color of the other phosphor.

Annual maximum and minimum lake levels for Indiana, 1942-85

USGS Publications Warehouse

Fowler, Kathleen K.

1988-01-01

Indiana has many natural and manmade lakes. Lake-level data are available for 217 lakes. These data were collected during water years 1942-85 by use of staff gages and, more recently, continuous recorders. The period of record at each site ranges from 1 to 43 years. Data from the lake stations have been compiled, and maximum and minimum lake levels for each year of record are reported. In addition to annual maximum and minimum lake levels, each lake station is described by gage location, surface area, drainage area, period of record, datum of gage, gage type, established legal level, lake level control, inlets and outlets, and extremes for the period of record. 

Informational primacy of visual dimensions: specialized roles for luminance and chromaticity in figure-ground perception.

PubMed

Yamagishi, N; Melara, R D

2001-07-01

Three experiments were conducted to examine the distinct contributions of two visual dimensions to figure-ground segregation. In each experiment, pattern identification was assessed by asking observers to judge whether a near-threshold test pattern was the same or different in shape to a high-contrast comparison pattern. A test pattern could differ from its background along one dimension, either luminance (luminance tasks) or chromaticity (chromaticity tasks). In each task, performance in a baseline condition, in which the test pattern was intact, was compared with performance in each of several degradation conditions, in which either the contour or the surface of the figure was degraded, using either partial occlusion (Experiment 1) or ramping (Experiments 2 and 3) of figure-ground differences. In each experiment, performance in luminance tasks was worst when the contour was degraded, whereas performance in chromaticity tasks was worst when the surface was degraded. This interaction was found even when spatial frequencies were fixed across test patterns by low-pass filtering. The results are consistent with a late (postfiltering) dual-mechanism system that processes luminance information to extract boundary representations and chromaticity information to extract surface representations.

Identification of Vibrio splendidus as a Member of the Planktonic Luminous Bacteria from the Persian Gulf and Kuwait Region with luxA Probes

PubMed Central

Nealson, K. H.; Wimpee, B.; Wimpee, C.

1993-01-01

Hybridization probes specific for the luxA genes of four groups of luminous bacteria were used to screen luminous isolates obtained from the Persian Gulf, near Al Khiran, Kuwait Nine of these isolates were identified as Vibrio harveyi, a commonly encountered planktonic isolate, while three others showed no hybridization to any of the four probes (V. harveyi, Vibrio fischeri, Photobacterium phosphoreum, or Photobacterium leiognathi) under high-stringency conditions. Polymerase chain reaction amplification was used to prepare a luxA probe against one of these isolates, K-1, and this probe was screened under high-stringency conditions against a collection of DNAs from luminous bacteria; it was found to hybridize specifically to the DNA of the species Vibrio splendidus. A probe prepared against the type strain of V. splendidus (ATCC 33369) was tested against the collection of luminous bacterial DNA preparations and against the Kuwait isolates and was found to hybridize only against the type strain and the three unidentified Kuwait isolates. Extensive taxonomic analysis by standard methods confirmed the identification of the 13 isolates. Images PMID:16349023

The effectiveness of a near-infrared vascular imaging device to support intravenous cannulation in children with dark skin color: a cluster randomized clinical trial.

PubMed

van der Woude, Olga C P; Cuper, Natascha J; Getrouw, Chavalleh; Kalkman, Cor J; de Graaff, Jurgen C

2013-06-01

Poor vein visibility can make IV cannulation challenging in children with dark skin color. In the operating room, we studied the effectiveness of a near-infrared vascular imaging device (VascuLuminator) to facilitate IV cannulation in children with dark skin color. In the operating room of a general hospital in Curacao, all consecutive children (0-15 years of age) requiring IV cannulation were included in a pragmatic cluster randomized clinical trial. The VascuLuminator was made available to anesthesiologists at the operating complex in randomized clusters of 1 week. Success at first attempt was 63% (27/43, 95% confidence interval [CI], 47%-77%) in the VascuLuminator group vs 51% (23 of 45 patients, 95% CI, 36%-66%) in the control group (P = 0.27). Median time to successful cannulation was 53 seconds (interquartile range: 34-154) in the VascuLuminator group and 68 seconds (interquartile range: 40-159) in the control group (P = 0.54), and hazard ratio was 1.12 (95% CI, 0.73-1.71). The VascuLuminator has limited value in improving success at first attempt of facilitating IV cannulation in children with dark skin color.

Color measurement and discrimination

NASA Technical Reports Server (NTRS)

Wandell, B. A.

1985-01-01

Theories of color measurement attempt to provide a quantative means for predicting whether two lights will be discriminable to an average observer. All color measurement theories can be characterized as follows: suppose lights a and b evoke responses from three color channels characterized as vectors, v(a) and v(b); the vector difference v(a) - v(b) corresponds to a set of channel responses that would be generated by some real light, call it *. According to theory a and b will be discriminable when * is detectable. A detailed development and test of the classic color measurement approach are reported. In the absence of a luminance component in the test stimuli, a and b, the theory holds well. In the presence of a luminance component, the theory is clearly false. When a luminance component is present discrimination judgements depend largely on whether the lights being discriminated fall in separate, categorical regions of color space. The results suggest that sensory estimation of surface color uses different methods, and the choice of method depends upon properties of the image. When there is significant luminance variation a categorical method is used, while in the absence of significant luminance variation judgments are continuous and consistant with the measurement approach.

Finding Hidden Quasars with UKIDSS and AAOmega

NASA Astrophysics Data System (ADS)

Maddox, Natasha; Hewett, P. C.; Warren, S. J.; Croom, S. M.

2007-05-01

The number of luminous quasars that have thus far eluded optical surveys is a subject of ongoing debate. Dust reddening and significant host galaxy light tend to exclude candidates from traditional UV-excess selection. UKIDSS, the near-infrared counterpart to SDSS, has started to provide the large area NIR data required to quantify the number of quasars missing from optical surveys. The quasar candidate list was chosen from the Early Data Release of the UKIDSS Large Area Survey (LAS), which aims to cover 2000 square degrees in two years. Requiring each object to have K<17, J<19.5 (the detection limit of the LAS) and a detection in SDSS were the only restrictions imposed on the candidates. A simple cut in gJK colour space, exploiting the K-band excess of quasars compared to stars, then separates the quasar candidates from the stellar locus. Optical-NIR colour selection with relaxed restrictions on morphology is less sensitive to dust reddening, so provides a more complete candidate list, suitable for follow-up observation with the new AAOmega spectrograph on the Anglo-Australian Telescope. With spectroscopic observations covering nearly 20 square degrees taken at the AAT, this is by far the largest K-band selected quasar sample to date. Many new quasars have been identified, in addition to known quasars being recovered. Several of the newly discovered quasars lie in regions of colour space typically excluded by UV selection. This study highlights the effectiveness of the K-excess technique in selecting quasars that do not necessarily exhibit the classic UV excess, either due to intrinsic SED shape or dust reddening. Combining upcoming UKIDSS data releases with scheduled AAT observations will increase the area surveyed by several times, thus moving closer to fully quantifying the number of luminous, reddened quasars.

Regulation of transmural transport of amino acid/metal conjugates by dietary calcium in crustacean digestive tract.

PubMed

Abdel-Malak, Rania; Ahearn, Gregory A

2014-03-01

Effects of luminal Ca(2+) and Mn(2+) on transmural mucosal to serosal (MS) transport of (3) H-L-leucine were characterized in the isolated and perfused intestine of the American lobster, Homarus americanus. (3) H-L-leucine MS transport in the presence of 20 µM Mn(2+) was a sigmoidal function of luminal amino acid concentration, following the Hill equation for multisite cooperative, carrier-mediated, transport. Luminal Ca(2+) was a non-competitive inhibitor of Mn(2+) -stimulated (3) H-L-leucine MS flux. Amino acid transport was hyperbolically stimulated by luminal Ca(2+) or Mn(2+). During 20 µM Mn(2+) -stimulation of (3) H-L-leucine MS flux, addition of 25 mM Ca(2+) strongly reduced amino acid transport Jmax , without affecting amino acid binding properties. Hyperbolic luminal Mn(2+) stimulation of 20 µM (3) H-L-leucine MS flux was also strongly inhibited by 25 mM luminal Ca(2+) , significantly reducing 20 µM (3) H-L-leucine Jmax . Increasing the luminal concentration of verapamil, a calcium channel blocker, significantly increased MS transport of 20 µM (3) H-L-leucine in the presence of 100 nM Mn(2+) by reducing diffusional Ca(2+) uptake into intestinal epithelial cells through verapamil-sensitive channels. A model is proposed supporting the concept of molecular mimicry, whereby (3) H-L-leucine enters lobster intestinal epithelial cells by one or more amino acid-specific transporters and by a dipeptide-like transporter that is capable of binding and transporting peptide molecular mimics (bis-complexes) between Ca(2+) or Mn(2+) and (3) H-L-leucine using the membrane potential as a major driving force for the transport event. According to the model, Ca(2+) entry through apical Ca(2+) channels regulates the magnitude of the membrane potential and therefore the size of the driving force for bis-complex uptake. © 2013 Wiley Periodicals, Inc.

Intrinsic subtypes from PAM50 gene expression assay in a population-based breast cancer cohort: Differences by age, race, and tumor characteristics

PubMed Central

Sweeney, Carol; Bernard, Philip S.; Factor, Rachel E.; Kwan, Marilyn L.; Habel, Laurel A.; Quesenberry, Charles P.; Shakespear, Kaylynn; Weltzien, Erin K.; Stijleman, Inge J.; Davis, Carole A.; Ebbert, Mark T.W.; Castillo, Adrienne; Kushi, Lawrence H.; Caan, Bette J.

2014-01-01

Background Data are lacking to describe gene expression-based breast cancer intrinsic subtype patterns for population-based patient groups. Methods We studied a diverse cohort of women with breast cancer from the Life After Cancer Epidemiology (LACE) and Pathways studies. RNA was extracted from 1 mm punches from fixed tumor tissue. Quantitative reverse-transcriptase polymerase chain reaction (RT-qPCR) was conducted for the 50 genes that comprise the PAM50 intrinsic subtype classifier. Results In a subcohort of 1,319 women, the overall subtype distribution based on PAM50 was 53.1% Luminal A, 20.5% Luminal B, 13.0% HER2-enriched, 9.8% Basal-like, and 3.6% Normal-like. Among low-risk endocrine positive tumors (i.e. estrogen and progesterone receptor positive by immunohistochemistry, Her2 negative, and low histologic grade), only 76.5% were categorized as Luminal A by PAM50. Continuous-scale Luminal A, Luminal B, HER2-enriched, and Normal-like scores from PAM50 were mutually positively correlated; Basal-like score was inversely correlated with other subtypes. The proportion with non-Luminal A subtype decreased with older age at diagnosis, p trend < 0.0001. Compared with non-Hispanic whites, African-American women were more likely to have Basal-like tumors, age-adjusted odds ratio (OR) 4.4 (95% CI 2.3,8.4), whereas Asian and Pacific Islander women had reduced odds of Basal-like subtype, OR 0.5 (95% CI 0.3,0.9). Conclusions Our data indicate that over 50% of breast cancers treated in the community have Luminal A subtype. Gene expression-based classification shifted some tumors categorized as low risk by surrogate clinicopathological criteria to higher-risk subtypes. Impact Subtyping in a population-based cohort revealed distinct profiles by age and race. PMID:24521995