N+3 Aircraft Concept Designs and Trade Studies. Volume 1

NASA Technical Reports Server (NTRS)

Greitzer, E. M.; Bonnefoy, P. A.; DelaRosaBlanco, E.; Dorbian, C. S.; Drela, M.; Hall, D. K.; Hansman, R. J.; Hileman, J. I.; Liebeck, R. H.; Levegren, J.;

Engineering the Business of Defense Acquisition: An Analysis of Program Office Processes

DTIC Science & Technology

2015-05-01

Information Technology and Business Process Redesign | MIT Sloan Management Review . MIT Sloan Management Review . Retrieved from http://sloanreview.mit.edu...links systems management to process execution Three Phases/ Multi-Year Effort (This Phase) Literature review Model development— Formal and...estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining

Teaching practical leadership in MIT satellite development class: CASTOR and Exoplanet projects

NASA Astrophysics Data System (ADS)

Babuscia, Alessandra; Craig, Jennifer L.; Connor, Jane A.

2012-08-01

For more than a decade, the Aeronautics and Astronautics Department at MIT has offered undergraduate students the opportunity of conceiving, developing, implementing and operating new spacecraft's missions. During a three term class, junior and senior students experience all the challenges of a true engineering team project: design, analysis, testing, technical documentation development, team management, and leadership. Leadership instruction is an important part of the curricula; through the development of leadership skills, students learn to manage themselves and each other in a more effective way, increasing the overall productivity of the team. Also, a strong leadership education is a key factor in improving the abilities of future engineers to be effective team members and leaders in the companies and agencies in which they will work. However, too often leadership instruction is presented in an abstract way, which does not provide students with suggestions for immediate applicability. As a consequence, students underestimate the potential that leadership education can have on the development of their projects. To counteract that effect, a new approach for teaching "practical" leadership has been developed. This approach is composed of a set of activities developed to improve students' leadership skills in the context of a project. Specifically, this approach has been implemented in the MIT satellite development class. In that class, students experienced the challenges of building two satellites: CASTOR and Exoplanet. These two missions are real space projects which will be launched in the next two years, and which involve cooperation with different entities (MIT, NASA, and Draper). Hence, the MIT faculty was interested in developing leadership activities to improve the productivity of the teams in a short time. In fact, one of the key aspects of the approach proposed is that it can be quickly implemented in a single semester, requiring no more than 4 h of activity. Data collected show that the approach improved the ability of students to interact productively with each other. This suggests that the activity can also be used in different contexts where a rapid and effective way of improving leadership and team membership is required. The article presents an overview of MIT satellite development class and of the two missions used as test cases, a detailed description of the leadership approach implemented, and of the results obtained.

50th Annual Technical Meeting of the Society of Engineering Science (SES)

DTIC Science & Technology

2014-08-15

McDowell (Gerogia Tech), Min Zhou () Virtual Characterization of composites with Lamination Defects for wind turbine spar cap MUKUNDAN SRINIVASAN...Zhang (IHCP Singapore) Damage Mechanisms in Irradiated Metallic Glasses Richard Baumer (MIT), Michael Demkowicz (MIT) Slip Avalanches in Amorphous...Michigan, 48090) Atomistic Simulations of c+a Pyramidal Slip in Magnesium Single Crystal under Compression Xiaozhi Tang (MIT & BJTU), Yafang Guo

Substrate-mediated strain effect on the role of thermal heating and electric field on metal-insulator transition in vanadium dioxide nanobeams.

PubMed

Kim, Min-Woo; Jung, Wan-Gil; Hyun-Cho; Bae, Tae-Sung; Chang, Sung-Jin; Jang, Ja-Soon; Hong, Woong-Ki; Kim, Bong-Joong

2015-06-04

Single-crystalline vanadium dioxide (VO2) nanostructures have recently attracted great attention because of their single domain metal-insulator transition (MIT) nature that differs from a bulk sample. The VO2 nanostructures can also provide new opportunities to explore, understand, and ultimately engineer MIT properties for applications of novel functional devices. Importantly, the MIT properties of the VO2 nanostructures are significantly affected by stoichiometry, doping, size effect, defects, and in particular, strain. Here, we report the effect of substrate-mediated strain on the correlative role of thermal heating and electric field on the MIT in the VO2 nanobeams by altering the strength of the substrate attachment. Our study may provide helpful information on controlling the properties of VO2 nanobeam for the device applications by changing temperature and voltage with a properly engineered strain.

Substrate-mediated strain effect on the role of thermal heating and electric field on metal-insulator transition in vanadium dioxide nanobeams

PubMed Central

Kim, Min-Woo; Jung, Wan-Gil; Hyun-Cho; Bae, Tae-Sung; Chang, Sung-Jin; Jang, Ja-Soon; Hong, Woong-Ki; Kim, Bong-Joong

2015-01-01

Single-crystalline vanadium dioxide (VO2) nanostructures have recently attracted great attention because of their single domain metal-insulator transition (MIT) nature that differs from a bulk sample. The VO2 nanostructures can also provide new opportunities to explore, understand, and ultimately engineer MIT properties for applications of novel functional devices. Importantly, the MIT properties of the VO2 nanostructures are significantly affected by stoichiometry, doping, size effect, defects, and in particular, strain. Here, we report the effect of substrate-mediated strain on the correlative role of thermal heating and electric field on the MIT in the VO2 nanobeams by altering the strength of the substrate attachment. Our study may provide helpful information on controlling the properties of VO2 nanobeam for the device applications by changing temperature and voltage with a properly engineered strain. PMID:26040637

Professor Joseph Warren Horton (1889-1967): biological engineer.

PubMed

Zeitlin, Gerald L

2005-02-01

Joseph Warren Horton graduated with a degree in electrical engineering from the Massachusetts Institute of Technology (MIT) in 1914. He became involved in the early development of electrical measurement devices, televised image transmission, and the detection of underwater sound transmission. In the mid-1930s he was appointed the first leader of the newly created Department of Biological Engineering at MIT and in this position he made major contributions to the application of physics to human physiology, in particular by increasing the safety of explosive inhalational anaesthetic agents.

77 FR 2096 - Proposal Review Panel for Materials Research; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-13

... Engineering Center (MRSEC) at Massachusetts Institute of Technology (MIT) by the Division of Materials... 16, 2012 7:15 a.m.-8:15 a.m. Closed--Executive Session 8:15 a.m.-5 p.m. Open--Review of the MIT MRSEC... session 9 a.m.-10 a.m. Open--Review of the MIT MRSEC 10 a.m.-4:30 p.m. Closed--Executive Session, Report...

Counterfeit Parts Prevention Strategies Guide

DTIC Science & Technology

2014-06-24

Boeing Byron Knight knightby@nro.mil NRO Hans Koenigsmann hans.koenigsmann@spacex.c om SpaceX James Koory james.koory@rocket.com Rocket Brian Kosinski...Deborah Valley deborah.valley@ll.mit.edu MIT Fred Van Milligen fvanmilligen@jdsu.com JDSU Marvin VanderWeg marvin.vanderwag@spacex.c om SpaceX Gerrit

Technical Risk Identification at Program Inception

DTIC Science & Technology

2014-04-20

boeing.com Byron Knight NRO knightby@nro.mil Hans Koenigsmann SpaceX hans.koenigsmann@spacex.c om James Koory Rocket james.koory@rocket.com Brian Kosinski...Deborah Valley MIT deborah.valley@ll.mit.edu Fred Van Milligen JDSU fvanmilligen@jdsu.com Marvin VanderWeg SpaceX marvin.vanderwag@spacex.c om Gerrit

Internationalizing Practical ChE Education: The M.I.T. Practice School in Japan.

ERIC Educational Resources Information Center

O'Connor, Andrea J.; Kandas, Angelo W.; Natori, Yukikazu; Hatton, T. Alan

1999-01-01

Describes the establishment, benefits, and difficulties of an overseas branch of the Massachusetts Institute of Technology's (MIT) chemical engineering Practice School for student internship study at the Mitsubishi Chemical Corporation's Mizushima Plant in Kurashiki, Japan. (WRM)

CrossTalk: The Journal of Defense Software Engineering. Volume 20, Number 10, October 2007

DTIC Science & Technology

2007-10-01

ch ...Re vie w Va lua tio n Ar ch ite cti ng De ve lop m en t 1 Ar ch ite cti ng 2 Ex plo ra tio n Op er at ion 1 De ve lop m en t 2 Ar ch ite cti ng 3...engineering systems from MIT. MIT 77 Massachusetts AVE NE20-388 Cambridge, MA 02139 Phone: (617) 324-0473 Fax: (617) 258- 7845 E-mail:

NASA Chief Technologist Speaks at Massachusetts Institute of Technology

NASA Image and Video Library

2018-02-15

NASA Chief Technologist Douglas Terrier joined students, faculty and experts in Boston as part of MIT's "Better MIT Innovation Week 2018," a week-long program promoting leadership, entrepreneurship and action for a better future. During the February event, Terrier spoke about a culture of innovation at America's Space Program. (Photo: Damian Barabonkov/MIT Technique)

Root Cause Investigation (RCI) Best Practices Guide Product Overview

DTIC Science & Technology

2014-05-08

micropac.com Andrew King Boeing andrew.m.king@boeing.com Byron Knight NRO knightby@nro.mil Hans Koenigsmann SpaceX hans.koenigsmann@spacex.com James Koory...ghislain.turgeon@sslmda.com Deborah Valley MIT deborah.valley@ll.mit.edu Fred Van Milligen JDSU fvanmilligen@jdsu.com Marvin VanderWeg SpaceX marvin.vanderwag

Nanoscale Engineering in VO2 Nanowires via Direct Electron Writing Process.

PubMed

Zhang, Zhenhua; Guo, Hua; Ding, Wenqiang; Zhang, Bin; Lu, Yue; Ke, Xiaoxing; Liu, Weiwei; Chen, Furong; Sui, Manling

2017-02-08

Controlling phase transition in functional materials at nanoscale is not only of broad scientific interest but also important for practical applications in the fields of renewable energy, information storage, transducer, sensor, and so forth. As a model functional material, vanadium dioxide (VO 2 ) has its metal-insulator transition (MIT) usually at a sharp temperature around 68 °C. Here, we report a focused electron beam can directly lower down the transition temperature of a nanoarea to room temperature without prepatterning the VO 2 . This novel process is called radiolysis-assisted MIT (R-MIT). The electron beam irradiation fabricates a unique gradual MIT zone to several times of the beam size in which the temperature-dependent phase transition is achieved in an extended temperature range. The gradual transformation zone offers to precisely control the ratio of metal/insulator phases. This direct electron writing technique can open up an opportunity to precisely engineer nanodomains of diversified electronic properties in functional material-based devices.

Studies on Three-Dimensional Slamming on Slender Ships

DTIC Science & Technology

2007-05-10

Objectives This study is a joint effort among MIT, Seoul National University (SNU), and Korean Research Institute of Ships and Ocean Engineering ( KRISO ...model and laboratory experiments were carried out by SNU/ KRISO . The key responsibility of MIT is to investigate the feasibility and effectiveness of

Biotechnology Process Engineering Center at MIT Home

Science.gov Websites

Bioengineering / Engineering Research Centers Georgia Tech / Emory Center for the Engineering of Living Tissues University of Washington / Engineered Biomaterials Engineering Research Center Vanderbilt University / VaNTH Surgical Systems and Technology Univesity of Hawaii / Marine Bioproducts Engineering Center Funding Sources

Precursor SSF utilization: The MODE experiments

NASA Technical Reports Server (NTRS)

Crawley, Edward F.

1992-01-01

The MIT Space Engineering Research Center is the principal investigator for a series of experiments which utilize the Shuttle Middeck as an engineering dynamics laboratory. The first, which flew on STS-48 in Sep. 1991, was the Middeck O-gravity Dynamics Experiment (MODE). This experiment focused on the dynamics of a scaled deployable truss, similar to that of SSF, and contained liquids in tanks. MODE will be reflown in the fall of 1993. In mid-1994, the Middeck Active Control Experiment (MACE) will examine the issues associated with predicting and verifying the closed loop behavior of a controlled structure in zero gravity. The paper will present experiment background, planning, operational experience, results, and lessons learned from these experiments which are pertinent to SSF utilization.

MIT January Operational Internship Experience

NASA Technical Reports Server (NTRS)

Bosanac, Natasha; DeVivero, Charlie; James, Jillian; Perez-Martinez, Carla; Pino, Wendy; Wang, Andrew; Willett, Ezekiel; Williams, Kwami

2010-01-01

This viewgraph presentation describes the MIT January Operational Internship Experience (JOIE) program. The topics include: 1) Landing and Recovery; 2) Transportation; 3) Shuttle Processing; 4) Constellation Processing; 5) External Tank; 6) Launch Pad; 7) Ground Operations; 8) Hypergolic Propellants; 9) Environmental; 10) Logistics; 11) Six Sigma; 12) Systems Engineering; and 13) Human Factors.

Shortfall of US Citizen Science and Engineering Specialists in Defense Industry

DTIC Science & Technology

2005-06-23

lower until equilibrium is restored. *e.g.,see Ch 1 & 4, Labor Economics , Cahuc & Zylberberg, MIT Press, 2004 Neoclassical Indicators: Increased...and balls concept Cobb-Douglas – hires as a function of job seekers and vacancies. *e.g.,see Ch 9, Labor Economics , Cahuc & Zylberberg, MIT Press

Comprehensive studies of interfacial strain and oxygen vacancy on metal-insulator transition of VO2 film

NASA Astrophysics Data System (ADS)

Fan, L. L.; Chen, S.; Liao, G. M.; Chen, Y. L.; Ren, H.; Zou, C. W.

2016-06-01

As a typical strong correlation material, vanadium dioxide (VO2) has attracted wide interest due to its particular metal-insulator transition (MIT) property. However, the relatively high critical temperature (T c) of ~68 °C seriously hinders its practical applications. Thus modulating the phase transition process and decreasing the T c close to room temperature have been hot topics for VO2 study. In the current work, we conducted a multi-approach strategy to control the phase transition of VO2 films, including the interfacial tensile/compressive strain and oxygen vacancies. A synchrotron radiation reciprocal space mapping technique was used to directly record the interfacial strain evolution and variations of lattice parameters. The effects of interfacial strain and oxygen vacancies in the MIT process were systematically investigated based on band structure and d-orbital electron occupation. It was suggested that the MIT behavior can be modulated through the combined effects of the interfacial strain and oxygen vacancies, achieving the distinct phase transition close to room temperature. The current findings not only provide better understanding for strain engineering and oxygen vacancies controlling phase transition behavior, but also supply a combined way to control the phase transition of VO2 film, which is essential for VO2 film based device applications in the future.

Comprehensive studies of interfacial strain and oxygen vacancy on metal-insulator transition of VO2 film.

PubMed

Fan, L L; Chen, S; Liao, G M; Chen, Y L; Ren, H; Zou, C W

2016-06-29

As a typical strong correlation material, vanadium dioxide (VO2) has attracted wide interest due to its particular metal-insulator transition (MIT) property. However, the relatively high critical temperature (T c) of ~68 °C seriously hinders its practical applications. Thus modulating the phase transition process and decreasing the T c close to room temperature have been hot topics for VO2 study. In the current work, we conducted a multi-approach strategy to control the phase transition of VO2 films, including the interfacial tensile/compressive strain and oxygen vacancies. A synchrotron radiation reciprocal space mapping technique was used to directly record the interfacial strain evolution and variations of lattice parameters. The effects of interfacial strain and oxygen vacancies in the MIT process were systematically investigated based on band structure and d-orbital electron occupation. It was suggested that the MIT behavior can be modulated through the combined effects of the interfacial strain and oxygen vacancies, achieving the distinct phase transition close to room temperature. The current findings not only provide better understanding for strain engineering and oxygen vacancies controlling phase transition behavior, but also supply a combined way to control the phase transition of VO2 film, which is essential for VO2 film based device applications in the future.

Biotechnology Process Engineering Center at MIT Home

Science.gov Websites

Research Summary Research Details of Project A (Stem Cell Vehicle Subthrust) and Project B (Targeted ) 253-0805 | Facsimile (617) 253-2400 | e-mail: bpec-www@mit.edu Current NSF ERC-Supported Research Vehicle Subthrust) Other Projects Related to NSF-Funded Research (coming soon) Home | People | Education

Education Outreach at M.I.T. Plasma Science and Fusion Center

NASA Astrophysics Data System (ADS)

Rivenberg, P.; Censabella, V.

2000-10-01

At the MIT PSFC student and staff volunteers work together to increase the public's knowledge of fusion and plasma-related experiments. Seeking to generate excitement about science, engineering and mathematics, the PSFC holds a number of outreach activities throughout the year, including Middle and High School Outreach Days and the Mr. Magnet program. During the past year, in collaboration with the MIT Museum, the PSFC reprogrammed their C-Mod, Jr Video Game to be operated via the keyboard instead of joysticks. The game will eventually be available on the web and on disc. The PSFC maintains a Home Page on the World Wide Web, which can be reached at http://www.psfc.mit.edu.

Environmental education and socioresponsive engineering. Report of an educational initiative in Hyderabad, India.

PubMed

Ansari, Ali Uddin; Jafari, Ashfaque; Mirzana, Ishrat Meera; Imtiaz, Zulfia; Lukacs, Heather

2003-07-01

A recent initiative at Muffakham Jah College of Engineering and Technology, Hyderabad, India, has resulted in setting up a program called Centre for Environment Studies and Socioresponsive Engineering which seeks to involve undergraduate students in studying and solving environmental problems in and around the city of Hyderabad, India. Two pilot projects have been undertaken--one focusing on design and construction of an eco-friendly house, The Natural House, and another directed at improving environmental and general living conditions in a slum area. The paper describes our attempts and experience of motivating our students to take interest in such projects. In an interesting development we invited a member of a student-faculty team at Massachusetts Institute of Technology (M.I.T.) that is doing a project in Nepal on safe drinking water. We report in our paper how the presentation by the guest from M.I.T. served as a catalyst for generating interest among civil and mechanical engineering students in our own projects. The paper includes contributions from one of our students and the M.I.T. staff member, reporting on their experiences related to the slum development project. We also discuss the Natural House project and its international and educational significance as a means of inculcating sensitivity and interest in nature among engineering students. We propose a pledge for engineers similar to the Hippocratic Oath for medical professionals.

Mishap Investigation Team (MIT) - Barksdale AFB, Louisiana

NASA Technical Reports Server (NTRS)

Stepaniak, Philip

2005-01-01

The Shuttle Program is organized to support a Shuttle mishap using the resources of the MIT. The afternoon of Feb. 1, 2003, the MIT deployed to Barksdale AFB. This location became the investigative center and interim storage location for crewmembers received from the Lufkin Disaster Field Office (DFO). Working under the leadership of the MIT Lead, the medical team executed a short-term plan that included search, recovery, and identification including coordination with the Armed Forces Institute of Pathology Temporary operations was set up at Barksdale Air Force Base for two weeks. During this time, coordination with the DFO field recovery teams, AFIP personnel, and the crew surgeons was on going. In addition, the crewmember families and NASA management were updated daily. The medical team also dealt with public reports and questions concerning biological and chemical hazards, which were coordinated with SPACEHAB, Inc., Kennedy Space Center (KSC) Medical Operations and the Johnson Space Center (JSC) Space Medicine office. After operations at Barksdale were concluded the medical team transitioned back to Houston and a long-term search, recovery and identification plan was developed.

Multi-Attribute Tradespace Exploration in Space System Design

NASA Astrophysics Data System (ADS)

Ross, A. M.; Hastings, D. E.

2002-01-01

The complexity inherent in space systems necessarily requires intense expenditures of resources both human and monetary. The high level of ambiguity present in the early design phases of these systems causes long, highly iterative, and costly design cycles. This paper looks at incorporating decision theory methods into the early design processes to streamline communication of wants and needs among stakeholders and between levels of design. Communication channeled through formal utility interviews and analysis enables engineers to better understand the key drivers for the system and allows a more thorough exploration of the design tradespace. Multi-Attribute Tradespace Exploration (MATE), an evolving process incorporating decision theory into model and simulation- based design, has been applied to several space system case studies at MIT. Preliminary results indicate that this process can improve the quality of communication to more quickly resolve project ambiguity, and enable the engineer to discover better value designs for multiple stakeholders. MATE is also being integrated into a concurrent design environment to facilitate the transfer knowledge of important drivers into higher fidelity design phases. Formal utility theory provides a mechanism to bridge the language barrier between experts of different backgrounds and differing needs (e.g. scientists, engineers, managers, etc). MATE with concurrent design couples decision makers more closely to the design, and most importantly, maintains their presence between formal reviews.

Transiting Exoplanet Survey Satellite (TESS) Briefing

NASA Image and Video Library

2018-03-28

NASA Astrophysics Division director Paul Hertz, left, Sara Seager, TESS deputy director of science, MIT, George Ricker, TESS principal investigator, MIT Kavli Institute for Astrophysics and Space Research, and Jeff Volosin, TESS project manager, NASA’s Goddard Space Flight Center, right, discuss the upcoming launch of NASA’s next planet hunter, the Transiting Exoplanet Survey Satellite (TESS), Wednesday, March 28, 2018 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

Energy Systems | Argonne National Laboratory

Science.gov Websites

Materials Engineering Research Facility Distributed Energy Research Center Engine Research Facility Heat Keeping the balance: How flexible nuclear operation can help add more wind and solar to the grid MIT News

MIT Lincoln Laboratory Takes the Mystery Out of Supercomupting

DTIC Science & Technology

2017-01-18

analysis, designing sensors, and developing algorithms. In 2008, the Lincoln demonstrated the largest single problem ever run on a computer using ... computation . As we design and prototype these devices, the use of leading–edge engineering practices have become the de facto standard. This includes...MIT Lincoln Laboratory Takes the Mystery Out of Supercomputing By Dr. Jeremy Kepner 1 The introduction of multicore and manycore processors

Medical imaging education in biomedical engineering curriculum: courseware development and application through a hybrid teaching model.

PubMed

Zhao, Weizhao; Li, Xiping; Chen, Hairong; Manns, Fabrice

2012-01-01

Medical Imaging is a key training component in Biomedical Engineering programs. Medical imaging education is interdisciplinary training, involving physics, mathematics, chemistry, electrical engineering, computer engineering, and applications in biology and medicine. Seeking an efficient teaching method for instructors and an effective learning environment for students has long been a goal for medical imaging education. By the support of NSF grants, we developed the medical imaging teaching software (MITS) and associated dynamic assessment tracking system (DATS). The MITS/DATS system has been applied to junior and senior medical imaging classes through a hybrid teaching model. The results show that student's learning gain improved, particularly in concept understanding and simulation project completion. The results also indicate disparities in subjective perception between junior and senior classes. Three institutions are collaborating to expand the courseware system and plan to apply it to different class settings.

Rapid Speech Transmission Index predictions and auralizations of unusual instructional spaces at MIT's new Stata Center

NASA Astrophysics Data System (ADS)

Conant, David A.

2005-04-01

The Stata Center for Computer, Information and Intelligence Sciences, recently opened at the Massachusetts Institute of Technology, includes a variety of oddly-shaped seminar rooms in addition to lecture spaces of somewhat more conventional form. The architects design approach prohibited following conventional, well understood room-acoustical behavior yet MIT and the design team were keenly interested in ensuring that these spaces functioned exceptionally well, acoustically. CATT-Acoustic room modeling was employed to assess RASTI through multiple design iterations for all these spaces. Presented here are computational and descriptive results achieved for these rooms which are highly-regarded by faculty. They all sound peculiarly good, given their unusual form. In addition, binaural auralizations for selected spaces are provided.

Biotechnology Process Engineering Center at MIT Home

Science.gov Websites

, 2003 BPEC Director Doug Lauffenburger in C&EN's coverstory on Systems Biology C&EN May 19th March 2003 Tissue engineering: The beat goes on Nature Februray 27th 2003 Molecular biology: A fix for

Infrared Active Sm1-xndxnio3 Based Nano-Switchings For High Powers Laser Sources

NASA Astrophysics Data System (ADS)

Ngom, B. D.; Kana, J. B. Kana; Nemraoui, O.; Manyala, N.; Maaza, M.; Mdjoe, R.; Beye, A. C.

2008-09-01

This contribution was targeted to engineer novel thermochromic infrared nano-structured photonics. These smart optically tuneable materials are based on rare earth nickelates in the form of ReNiO3 where Re is bi-solution of rare earth metals of Samarium "Sm" and Neodynium "Nd." In addition to their Metal-Insulator tuneable transition temperature (MIT), these MIT oxide family exhibit a specific thermal stability and thus could be ideal to an ultimate optical limiting and other Non-Linear Optical properties for high power laser sources. This MIT thermochomic ReNiO3 system is novel in its nano-structured form and has not been investigated from nonlinear optical viewpoint. This contribution reports on the optimization of the synthesis of Sm1-xNdxNiO3 Nano-structures and investigation of their corresponding MIT electron dynamics.

Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release

PubMed Central

Thompson, Jeremy; Hu, Ying; Lesnefsky, Edward J.

2015-01-01

Calpain 1 (CPN1) is a ubiquitous cysteine protease that exists in both cytosol and cardiac mitochondria. Mitochondrial CPN1 (mit-CPN1) is located in the intermembrane space and matrix. Activation of mit-CPN1 within the intermembrane space increases cardiac injury by releasing apoptosis-inducing factor from mitochondria during ischemia-reperfusion (IR). We asked if activation of mit-CPN1 is involved in mitochondrial injury during IR. MDL-28170 (MDL) was used to inhibit CPN1 in buffer-perfused hearts following 25-min ischemia and 30-min reperfusion. MDL treatment decreased the release of lactate dehydrogenase into coronary effluent compared with untreated hearts, indicating that inhibition of CPN1 decreases cardiac injury. MDL also prevented the cleavage of spectrin (a substrate of CPN1) in cytosol during IR, supporting that MDL treatment decreased cytosolic calpain activation. In addition, MDL markedly improved calcium retention capacity compared with untreated heart, suggesting that MDL treatment decreases mitochondrial permeability transition pore opening. In addition, we found that IR led to decreased complex I activity, whereas inhibition of mit-CPN1 using MDL protected complex I. Pyruvate dehydrogenase content was decreased following IR. However, pyruvate dehydrogenase content was preserved in MDL-treated mitochondria. Taken together, MDL treatment decreased cardiac injury during IR by inhibiting both cytosolic and mit-CPN1. Activation of mit-CPN1 increases cardiac injury during IR by sensitizing mitochondrial permeability transition pore opening and impairing mitochondrial metabolism through damage of complex I. PMID:26637561

A future Chinese mission proposed to investigate the coupling of the Earth's magnetoshpere, ionosphere and thermoshpere

NASA Astrophysics Data System (ADS)

Liu, Y.; Wang, C.; Xu, J.

2013-12-01

Under the support of Chinese Strategy Pioneer Program for space science, we are developing a mission to investigate a key question for space weather. The Earth's magnetosphere, ionosphere and thermosphere (MIT) are crucial regions for the space and they are coupling together through exchange of energy, momentum and mass. The mission, named as MIT, focuses on the polar upflow ions which are vital for the understanding of the physical processes relating to the MIT coupling. The mission plans a constellation composed of four spacecrafts, each spacecraft has its own orbit and crosses the polar region at the nearly the same time but at different altitude. With particles detectors, field detectors and imagers onboard each spacecraft, we will be able to track the polar upflow ions and study the acceleration mechanism at different altitude. Currently we have determined the orbits, the payloads for each the spacecraft and the expected lunch time is 2019 to 2020.

MIT-NASA/KSC space life science experiments - A telescience testbed

NASA Technical Reports Server (NTRS)

Oman, Charles M.; Lichtenberg, Byron K.; Fiser, Richard L.; Vordermark, Deborah S.

1990-01-01

Experiments performed at MIT to better define Space Station information system telescience requirements for effective remote coaching of astronauts by principal investigators (PI) on the ground are described. The experiments were conducted via satellite video, data, and voice links to surrogate crewmembers working in a laboratory at NASA's Kennedy Space Center. Teams of two PIs and two crewmembers performed two different space life sciences experiments. During 19 three-hour interactive sessions, a variety of test conditions were explored. Since bit rate limits are necessarily imposed on Space Station video experiments surveillance video was varied down to 50 Kb/s and the effectiveness of PI controlled frame rate, resolution, grey scale, and color decimation was investigated. It is concluded that remote coaching by voice works and that dedicated crew-PI voice loops would be of great value on the Space Station.

Optimum and Heuristic Algorithms for Finite State Machine Decomposition and Partitioning

DTIC Science & Technology

1989-09-01

Heuristic Algorithms for Finite State Machine Decomposition and Partitioning Pravnav Ashar, Srinivas Devadas , and A. Richard Newton , T E’,’ .,jpf~s’!i3...94720. Devadas : Department of Electrical Engineering and Computer Science, Room 36-848, MIT, Cambridge, MA 02139. (617) 253-0454. Copyright* 1989 MIT...and reduction, A finite state miachinie is represenutedl by its State Transition Graphi itodlitied froini two-level B ~oolean imiinimizers. Ilist

Fine structure of metal-insulator transition in EuO resolved by doping engineering.

PubMed

Averyanov, Dmitry V; Parfenov, Oleg E; Tokmachev, Andrey M; Karateev, Igor A; Kondratev, Oleg A; Taldenkov, Alexander N; Platunov, Mikhail S; Wilhelm, Fabrice; Rogalev, Andrei; Storchak, Vyacheslav G

2018-05-11

Metal-insulator transitions (MITs) offer new functionalities for nanoelectronics. However, ongoing attempts to control the resistivity by external stimuli are hindered by strong coupling of spin, charge, orbital and lattice degrees of freedom. This difficulty presents a quest for materials which exhibit MIT caused by a single degree of freedom. In the archetypal ferromagnetic semiconductor EuO, magnetic orders dominate the MIT. Here we report a new approach to take doping under control in this material on the nanoscale: formation of oxygen vacancies is strongly suppressed to exhibit the highest MIT resistivity jump and magnetoresistance among thin films. The nature of the MIT is revealed in Gd doped films. The critical doping is determined to be more than an order of magnitude lower than in all previous studies. In lightly doped films, a remarkable thermal hysteresis in resistivity is discovered. It extends over 100 K in the paramagnetic phase reaching 3 orders of magnitude. In the warming mode, the MIT is shown to be a two-step process. The resistivity patterns are consistent with an active role of magnetic polarons-formation of a narrow band and its thermal destruction. High-temperature magnetic polaron effects include large negative magnetoresistance and ferromagnetic droplets revealed by x-ray magnetic circular dichroism. Our findings have wide-range implications for the understanding of strongly correlated oxides and establish fundamental benchmarks to guide theoretical models of the MIT.

Fine structure of metal–insulator transition in EuO resolved by doping engineering

NASA Astrophysics Data System (ADS)

Averyanov, Dmitry V.; Parfenov, Oleg E.; Tokmachev, Andrey M.; Karateev, Igor A.; Kondratev, Oleg A.; Taldenkov, Alexander N.; Platunov, Mikhail S.; Wilhelm, Fabrice; Rogalev, Andrei; Storchak, Vyacheslav G.

2018-05-01

Metal–insulator transitions (MITs) offer new functionalities for nanoelectronics. However, ongoing attempts to control the resistivity by external stimuli are hindered by strong coupling of spin, charge, orbital and lattice degrees of freedom. This difficulty presents a quest for materials which exhibit MIT caused by a single degree of freedom. In the archetypal ferromagnetic semiconductor EuO, magnetic orders dominate the MIT. Here we report a new approach to take doping under control in this material on the nanoscale: formation of oxygen vacancies is strongly suppressed to exhibit the highest MIT resistivity jump and magnetoresistance among thin films. The nature of the MIT is revealed in Gd doped films. The critical doping is determined to be more than an order of magnitude lower than in all previous studies. In lightly doped films, a remarkable thermal hysteresis in resistivity is discovered. It extends over 100 K in the paramagnetic phase reaching 3 orders of magnitude. In the warming mode, the MIT is shown to be a two-step process. The resistivity patterns are consistent with an active role of magnetic polarons—formation of a narrow band and its thermal destruction. High-temperature magnetic polaron effects include large negative magnetoresistance and ferromagnetic droplets revealed by x-ray magnetic circular dichroism. Our findings have wide-range implications for the understanding of strongly correlated oxides and establish fundamental benchmarks to guide theoretical models of the MIT.

Engineering Outreach through College Pre-Orientation Programs: MIT Discover Engineering

ERIC Educational Resources Information Center

Thompson, Mary Kathryn; Consi, Thomas R.

2007-01-01

Freshmen Pre-Orientation Programs (FPOPs) can be powerful outreach tools for incoming college students and provide an exciting introduction to the field of engineering. The benefits reach not only the first year students, but also the upperclassmen who help to run the programs and the departments that sponsor them. A family of three engineering…

MIT-KSC space life sciences telescience testbed

NASA Technical Reports Server (NTRS)

1989-01-01

A Telescience Life Sciences Testbed is being developed. The first phase of this effort consisted of defining the experiments to be performed, investigating the various possible means of communication between KSC and MIT, and developing software and hardware support. The experiments chosen were two vestibular sled experiments: a study of ocular torsion produced by Y axis linear acceleration, based on the Spacelab D-1 072 Vestibular Experiment performed pre- and post-flight at KSC; and an optokinetic nystagmus (OKN)/linear acceleration interaction experiment. These two experiments were meant to simulate actual experiments that might be performed on the Space Station and to be representative of space life sciences experiments in general in their use of crew time and communications resources.

The Golden Age of Radio: Solid State's Debt to the Rad Lab

NASA Astrophysics Data System (ADS)

Martin, Joseph D.

2011-03-01

While MIT's Radiation Laboratory is rightly celebrated for its contributions to World War II radar research, its legacy extended beyond the war. The Rad Lab provided a model for interdisciplinary collaboration that continued to influence research at MIT in the post-war decades. The Rad Lab's institutional legacy--MIT's interdepartmental laboratories--drove the Institute's postwar research agenda. This talk examines how solid state physics research at MIT was shaped by a laboratory structure that encouraged cross-disciplinary collaboration. As the sub-discipline of solid state physics emerged through the late-1940s and 1950s, MIT was unique among universities in its laboratory structure, made possible by a large degree of government and military funding. Nonetheless, the manner in which MIT research groups from physics, chemistry, engineering, and metallurgy interfaced through the medium of solid state physics exemplified how the discipline of solid state physics came to be structured in the rest of the country. Through examining the Rad Lab's institutional legacy, I argue that World War II radar research, by establishing precedent for a particular mode of interdisciplinary collaboration, shaped the future structure of solid state research in the United States. Research supported by a grant-in-aid from the Friends of the Center for the History of Physics, American Institute of Physics.

Suppression of Structural Phase Transition in VO2 by Epitaxial Strain in Vicinity of Metal-insulator Transition

PubMed Central

Yang, Mengmeng; Yang, Yuanjun; Bin Hong; Wang, Liangxin; Hu, Kai; Dong, Yongqi; Xu, Han; Huang, Haoliang; Zhao, Jiangtao; Chen, Haiping; Song, Li; Ju, Huanxin; Zhu, Junfa; Bao, Jun; Li, Xiaoguang; Gu, Yueliang; Yang, Tieying; Gao, Xingyu; Luo, Zhenlin; Gao, Chen

2016-01-01

Mechanism of metal-insulator transition (MIT) in strained VO2 thin films is very complicated and incompletely understood despite three scenarios with potential explanations including electronic correlation (Mott mechanism), structural transformation (Peierls theory) and collaborative Mott-Peierls transition. Herein, we have decoupled coactions of structural and electronic phase transitions across the MIT by implementing epitaxial strain on 13-nm-thick (001)-VO2 films in comparison to thicker films. The structural evolution during MIT characterized by temperature-dependent synchrotron radiation high-resolution X-ray diffraction reciprocal space mapping and Raman spectroscopy suggested that the structural phase transition in the temperature range of vicinity of the MIT is suppressed by epitaxial strain. Furthermore, temperature-dependent Ultraviolet Photoelectron Spectroscopy (UPS) revealed the changes in electron occupancy near the Fermi energy EF of V 3d orbital, implying that the electronic transition triggers the MIT in the strained films. Thus the MIT in the bi-axially strained VO2 thin films should be only driven by electronic transition without assistance of structural phase transition. Density functional theoretical calculations further confirmed that the tetragonal phase across the MIT can be both in insulating and metallic states in the strained (001)-VO2/TiO2 thin films. This work offers a better understanding of the mechanism of MIT in the strained VO2 films. PMID:26975328

MIT Lincoln Laboratory 2011 Facts

DTIC Science & Technology

2011-01-01

currently valid OMB control number. 1. REPORT DATE 2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE MIT Lincoln...primary mission areas—space control ; air and missile defense; communication systems; intelligence, surveillance, and reconnaissance systems; advanced...electronics; tactical systems; homeland protection and chemical and biological defense; cyber security; and air traffic control . Two of the

MIT Lincoln Laboratory 2010 Facts

DTIC Science & Technology

2010-03-01

currently valid OMB control number. 1. REPORT DATE 2010 2. REPORT TYPE 3. DATES COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE MIT Lincoln...space control ; air and missile defense; communications and information technology; intelligence, surveillance, and reconnaissance systems...advanced electronics; tactical systems; homeland protection and biological/chemical defense; and air traffic control . Two of the Laboratory’s principal

Key role of lattice symmetry in the metal-insulator transition of NdNiO 3 films

DOE PAGES

Zhang, Jack Y.; Kim, Honggyu; Mikheev, Evgeny; ...

2016-04-01

Here, bulk NdNiO 3 exhibits a metal-to-insulator transition (MIT) as the temperature is lowered that is also seen in tensile strained films. In contrast, films that are under a large compressive strain typically remain metallic at all temperatures. To clarify the microscopic origins of this behavior, we use position averaged convergent beam electron diffraction in scanning transmission electron microscopy to characterize strained NdNiO 3 films both above and below the MIT temperature. We show that a symmetry lowering structural change takes place in case of the tensile strained film, which undergoes an MIT, but is absent in the compressively strainedmore » film. Using space group symmetry arguments, we show that these results support the bond length disproportionation model of the MIT in the rare-earth nickelates. Furthermore, the results provide insights into the non-Fermi liquid phase that is observed in films for which the MIT is absent.« less

MIT January Operational Internship Experience 2011

NASA Technical Reports Server (NTRS)

DeLatte, Danielle; Furhmann, Adam; Habib, Manal; Joujon-Roche, Cecily; Opara, Nnaemeka; Pasterski, Sabrina Gonzalez; Powell, Christina; Wimmer, Andrew

2011-01-01

This slide presentation reviews the 2011 January Operational Internship experience (JOIE) program which allows students to study operational aspects of spaceflight, how design affects operations and systems engineering in practice for 3 weeks. Topics include: (1) Systems Engineering (2) NASA Organization (3) Workforce Core Values (4) Human Factors (5) Safety (6) Lean Engineering (7) NASA Now (8) Press, Media, and Outreach and (9) Future of Spaceflight.

Use of graphics in decision aids for telerobotic control: (Parts 5-8 of an 8-part MIT progress report)

NASA Technical Reports Server (NTRS)

Sheridan, Thomas B.; Roseborough, James B.; Das, Hari; Chin, Kan-Ping; Inoue, Seiichi

1989-01-01

Four separate projects recently completed or in progress at the MIT Man-Machine Systems Laboratory are summarized. They are: a decision aid for retrieving a tumbling satellite in space; kinematic control and graphic display of redundant teleoperators; real time terrain/object generation: a quad-tree approach; and two dimensional control for three dimensional obstacle avoidance.

C. Judson King of UC Berkeley

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prausnitz, John

2005-06-01

In the middle of the UC Berkeley campus, next to the Main Library, South Hall is the last surviving building from the original campus, founded about 135 years ago. A tiny tree-shaded appendix to this venerated classical building houses Berkeley's Center for Studies in Higher Education, directed by C. Judson King, former Provost and Senior Vice President--Academic Affairs of the ten-campus University of California and long-time Professor of Chemical Engineering at Berkeley. Jud came to Berkeley in 1963 as assistant professor of chemical engineering, following receipt of a doctor's degree from MIT and a subsequent short appointment as director ofmore » the MIT chemical engineering practice school station at what was then Esso (now Exxon) in New Jersey. His undergraduate degree is from Yale. Starting with his MIT doctoral dissertation on gas absorption, Jud has devoted much of his professional career to separation processes. His teaching and research activities have been primarily concerned with separation of mixtures with emphasis on liquid-liquid extraction and drying. As a consultant to Procter and Gamble, he contributed to the technology of making instant coffee. His life-long activities in hiking and camping stimulated Jud's interest in the manufacture of freeze-dried foods (e.g. turkey meat) to minimize the weight of his hiking back-pack. Jud is internationally known not only for his many research publications but even more, for his acclaimed textbook ''Separation Processses'' (McGraw-Hill, second edition 1980) that is used in standard chemical engineering courses in the US and abroad.« less

Microfabricated X-Ray Optics Technology Development for the Constellation-X Mission

NASA Technical Reports Server (NTRS)

Schattenburg, Mark L.

2003-01-01

During the period of this Cooperative Agreement, MIT developed advanced methods for applying silicon micro-stuctures for the precision assembly of foil x-ray optics in support of the Constellution-X Spectroscopy X-ray Telescope (SXT) development effort at Goddard Space Flight Center (GSFC). MIT developed improved methods for fabricating and characterizing the precision silicon micro-combs. MIT also developed and characterized assembly tools and several types of metrology tools in order to characterize and reduce the errors associated with precision assembly of foil optics. Results of this effort were published and presented to the scientific community and the GSFC SXT team.

Tunable metal-insulator transition in Nd{sub 1−x}Y{sub x}NiO{sub 3} (x = 0.3, 0.4) perovskites thin film at near room temperature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shao, Tao; Qi, Zeming, E-mail: zmqi@ustc.edu.cn; Wang, Yuyin

2015-07-13

Metal-insulator transition (MIT) occurs due to the charge disproportionation and lattice distortions in rare-earth nickelates. Existing studies revealed that the MIT behavior of rare-earth nickelates is fairly sensitive to external stress/pressure, suggesting a viable route for MIT strain engineering. Unlike applying extrinsic strain, the MIT can also be modulated by through rare-earth cation mixing, which can be viewed as intrinsic quantum stress. We choose Nd{sub 1−X}Y{sub X}NiO{sub 3} (x = 0.3, 0.4) perovskites thin films as a prototype system to exhibit the tunable sharp MIT at near room temperature. By adjusting Y concentration, the transition temperature of the thin films can bemore » changed within the range of 340–360 K. X-ray diffraction, X-ray absorption fine structure (XAFS), and in situ infrared spectroscopy are employed to probe the structural and optical property variation affected by composition and temperature. The infrared transmission intensity decreases with temperature across the MIT, indicating a pronounced thermochromic effect. Meanwhile, the XAFS result exhibits that the crystal atomistic structure changes accompanying with the Y atoms incorporation and MIT phase transition. The heavily doped Y atoms result in the pre-edge peak descent and Ni-O bond elongation, suggesting an enhanced charge disproportionation effect and the weakening of hybridization between Ni-3d and O-2p orbits.« less

MIT Lincoln Laboratory Annual Report 2009

DTIC Science & Technology

2009-01-01

unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 MIt lincoln laboratory Massachusetts Institute...Climate-change monitoring that will be conducted by assessing the utility of using very-long-wave infrared radiation for space-based sensing and by... radiation to detect trace explosives on a person’s hair were investigated. An ultrasensitive THz receiver leverages mature technology at the near-infrared

Transforming the Gray Factory: The Presidential Leadership of Charles M. Vest and the Architecture of Change at Massachusetts Institute of Technology

ERIC Educational Resources Information Center

Daas, Mahesh

2013-01-01

The single-site exemplar study presents an in-depth account of the presidential leadership of Charles M. Vest of MIT--the second longest presidency in the Institute's history--and his leadership team's journey between 1990 and 2004 into campus architectural changes that involved over a billion dollars, added a quarter of floor space to MIT's…

What do K-12 students feel when dealing with technology and engineering issues? Gardner's multiple intelligence theory implications in technology lessons for motivating engineering vocations at Spanish Secondary School

NASA Astrophysics Data System (ADS)

Sánchez-Martín, Jesús; Álvarez-Gragera, García J.; Dávila-Acedo, M. Antonia; Mellado, Vicente

2017-11-01

The interest on engineering and scientific studies can be raised up even from the early years of academic instructional process. This vocation may be linked to emotions and aptitudes towards technological education. Particularly, students get in touch with these technological issues (namely STEM) during the Compulsory Secondary Education in Spain (12-16 years old).This work presents a preliminary evaluation of how relevant is Gardner's multiple intelligence theory (MIT) in the teaching-learning process within the Technology Lessons. In this sense, MIT was considered as an explanation variable of the emotional response within the different educational parts (so-called syllabus units, SU) in the Technology spanish curriculum. Different intelligence style (IS) will orient the student to a vision of the engineering and technology. This work tries to identify which relationships can be established between IS and specific technology and engineering learning. This research involved up to 135 students were subsequently tested about their predominant (IS) and on the emotions that arouse in them when working with each SU. The results were statistically significant and only those with a Logic-arithmetic or Environmental IS were not affected by the SU.Best teaching and learning practicesare required for encouraging further engineering studies.

MIT Clean Energy Prize: Final Technical Report May 12, 2010 - May 11, 2011

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snyder, Chris; Campbell, Georgina; Salony, Jason

2011-08-09

The MIT Clean Energy Prize (MIT CEP) is a venture creation and innovation competition to encourage innovation in the energy space, specifically with regard to clean energy. The Competition invited student teams from any US university to submit student-led ventures that demonstrate a high potential of successfully making clean energy more affordable, with a positive impact on the environment. By focusing on student ventures, the MIT CEP aims to educate the next generation of clean energy entrepreneurs. Teams receive valuable mentoring and hard deadlines that complement the cash prize to accelerate development of ventures. The competition is a year-long educationalmore » process that culminates in the selection of five category finalists and a Grand Prize winner and the distribution of cash prizes to each of those teams. Each entry was submitted in one of five clean energy categories: Renewables, Clean Non-Renewables, Energy Efficiency, Transportation, and Deployment.« less

Biotechnology Process Engineering Center at MIT Home

Science.gov Websites

is speaking at the 2004 Congressional Biomedical Research Caucus Briefings on July 14th. Her briefing | Education & Outreach | Research | Industrial Programs | Student Leadership Council Facilities | Umbrella

Assessing the Pedagogical Impact of the VaNTH Engineering Research Center on Faculty and Postdoctoral Professionals

ERIC Educational Resources Information Center

Cox, Monica; Cawthorne, James; McNeill, Nathan; Cekic, Osman; Frye, Matthew; Stacer, Melissa

2011-01-01

From 1999 to 2007, the Vanderbilt-Northwestern-Texas-Harvard/MIT (VaNTH) Engineering Research Center focused on improving bioengineering education through the applications of learning science, learning technology, and assessment and evaluation within the domain of bioengineering. This paper discusses results from a survey to explore the impact of…

Fabrication and Metrology of High-Precision Foil Mirror Mounting Elements

NASA Technical Reports Server (NTRS)

Schattenburg, Mark L.

2002-01-01

During the period of this Cooperative Agreement, MIT (Massachusetts Institute of Technology) developed advanced methods for applying silicon microstructures for the precision assembly of foil x-ray optics in support of the Constellation-X Spectroscopy X-ray Telescope (SXT) development effort at Goddard Space Flight Center (GSFC). MIT developed improved methods for fabricating and characterizing the precision silicon micro-combs. MIT also developed and characterized assembly tools and several types of metrology tools in order to characterize and reduce the errors associated with precision assembly of foil optics. Results of this effort were published and presented to the scientific community and the GSFC SXT team. A bibliography of papers and presentations is offered.

MIT's interferometer CST testbed

NASA Technical Reports Server (NTRS)

Hyde, Tupper; Kim, ED; Anderson, Eric; Blackwood, Gary; Lublin, Leonard

1990-01-01

The MIT Space Engineering Research Center (SERC) has developed a controlled structures technology (CST) testbed based on one design for a space-based optical interferometer. The role of the testbed is to provide a versatile platform for experimental investigation and discovery of CST approaches. In particular, it will serve as the focus for experimental verification of CSI methodologies and control strategies at SERC. The testbed program has an emphasis on experimental CST--incorporating a broad suite of actuators and sensors, active struts, system identification, passive damping, active mirror mounts, and precision component characterization. The SERC testbed represents a one-tenth scaled version of an optical interferometer concept based on an inherently rigid tetrahedral configuration with collecting apertures on one face. The testbed consists of six 3.5 meter long truss legs joined at four vertices and is suspended with attachment points at three vertices. Each aluminum leg has a 0.2 m by 0.2 m by 0.25 m triangular cross-section. The structure has a first flexible mode at 31 Hz and has over 50 global modes below 200 Hz. The stiff tetrahedral design differs from similar testbeds (such as the JPL Phase B) in that the structural topology is closed. The tetrahedral design minimizes structural deflections at the vertices (site of optical components for maximum baseline) resulting in reduced stroke requirements for isolation and pointing of optics. Typical total light path length stability goals are on the order of lambda/20, with a wavelength of light, lambda, of roughly 500 nanometers. It is expected that active structural control will be necessary to achieve this goal in the presence of disturbances.

Net-Centric Sensors and Data Sources (N-CSDS) GEODSS Sidecar

NASA Astrophysics Data System (ADS)

Richmond, D.

2012-09-01

Vast amounts of Space Situational Sensor data is collected each day on closed, legacy systems. Massachusetts Institute of Technology Lincoln Laboratory (MIT/LL) developed a Net-Centric approach to expose this data under the Extended Space Sensors Architecture (ESSA) Advanced Concept Technology Demonstration (ACTD). The Net-Centric Sensors and Data Sources (N-CSDS) Ground-based Electro Optical Deep Space Surveillance (GEODSS) Sidecar is the next generation that moves the ESSA ACTD engineering tools to an operational baseline. The N-CSDS GEODSS sidecar high level architecture will be presented, highlighting the features that supports deployment at multiple diverse sensor sites. Other key items that will be covered include: 1) The Web Browser interface to perform searches of historical data 2) The capabilities of the deployed Web Services and example service request/responses 3) Example data and potential user applications will be highlighted 4) Specifics regarding the process to gain access to the N-CSDS GEODSS sensor data in near real time 5) Current status and future deployment plans (Including plans for deployment to the Maui GEODSS Site)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kubik, Michelle

A comprehensive assessment of enhanced, or engineered, geothermal systems was carried out by an 18-member panel assembled by the Massachusetts Institute of Technology (MIT) to evaluate the potential of geothermal energy becoming a major energy source for the United States.

LLIMAS: Revolutionizing integrating modeling and analysis at MIT Lincoln Laboratory

NASA Astrophysics Data System (ADS)

Doyle, Keith B.; Stoeckel, Gerhard P.; Rey, Justin J.; Bury, Mark E.

2017-08-01

MIT Lincoln Laboratory's Integrated Modeling and Analysis Software (LLIMAS) enables the development of novel engineering solutions for advanced prototype systems through unique insights into engineering performance and interdisciplinary behavior to meet challenging size, weight, power, environmental, and performance requirements. LLIMAS is a multidisciplinary design optimization tool that wraps numerical optimization algorithms around an integrated framework of structural, thermal, optical, stray light, and computational fluid dynamics analysis capabilities. LLIMAS software is highly extensible and has developed organically across a variety of technologies including laser communications, directed energy, photometric detectors, chemical sensing, laser radar, and imaging systems. The custom software architecture leverages the capabilities of existing industry standard commercial software and supports the incorporation of internally developed tools. Recent advances in LLIMAS's Structural-Thermal-Optical Performance (STOP), aeromechanical, and aero-optical capabilities as applied to Lincoln prototypes are presented.

Learning Shape Descriptions: Generating and Generalizing Models of Visual Objects.

DTIC Science & Technology

1985-09-01

Minsky , Marvin and Seymour Papert, [1969], Perceptrons, MIT Press, Cam- bridge, Ma. Mitchell, T. M., [1978], "Version spaces: A candidiate elimination...with respect to a suitable set of affine transformations. This is one area in which classic perceptrons fall short [ Minsky and Papert 19691. The third...Quillian, M. Ross, [1968], "Semantic Memory" (PhD Thesis), in Semantic Infor- mation Processing, M. Minsky (ed.), MIT Press, Cambridge MA. Schlesinger, G

Preliminary Structural Design - Defining the Design Space

DTIC Science & Technology

1993-02-01

York, 1949 7. Rosenblatt, R., Prnciples of Neurodynamics , New York, Spartan Books, 1959 8. Swift, R.,"Structural Design Using Neural Networks," Ph.D...Explorations in the Microstructure of Cognition . Vol. 1 Foundations D. E. Rumelhart and J.L. McClelland Editors, MIT Press, 1986 40. Parker, D. B...Processing: Explorations in the Microstructure of Cognition , MIT Press 1986 45. Schittkowski, K., Nonlinear o a gmi codes Lecture Notes in Economics and

A design methodology for neutral buoyancy simulation of space operations

NASA Technical Reports Server (NTRS)

Akin, David L.

1988-01-01

Neutral buoyancy has often been used in the past for EVA development activities, but little has been done to provide an analytical understanding of the environment and its correlation with space. This paper covers a set of related research topics at the MIT Space Systems Laboratory, dealing with the modeling of the space and underwater environments, validation of the models through testing in neutral buoyancy, parabolic flight, and space flight experiments, and applications of the models to gain a better design methodology for creating meaningful neutral buoyancy simulations. Examples covered include simulation validation criteria for human body dynamics, and for applied torques in a beam rotation task, which is the pacing crew operation for EVA structural assembly. Extensions of the dynamics models are presented for powered vehicles in the underwater environment, and examples given from the MIT Space Telerobotics Research Program, including the Beam Assembly Teleoperator and the Multimode Proximity Operations Device. Future expansions of the modeling theory are also presented, leading to remote vehicles which behave in neutral buoyancy exactly as the modeled system would in space.

Medical Devices Assess, Treat Balance Disorders

NASA Technical Reports Server (NTRS)

2009-01-01

You may have heard the phrase as difficult as walking and chewing gum as a joking way of referring to something that is not difficult at all. Just walking, however, is not all that simple physiologically speaking. Even standing upright is an undertaking requiring the complex cooperation of multiple motor and sensory systems including vision, the inner ear, somatosensation (sensation from the skin), and proprioception (the sense of the body s parts in relation to each other). The compromised performance of any of these elements can lead to a balance disorder, which in some form affects nearly half of Americans at least once in their lifetimes, from the elderly, to those with neurological or vestibular (inner ear) dysfunction, to athletes with musculoskeletal injuries, to astronauts returning from space. Readjusting to Earth s gravity has a significant impact on an astronaut s ability to balance, a result of the brain switching to a different "model" for interpreting sensory input in normal gravity versus weightlessness. While acclimating, astronauts can experience headaches, motion sickness, and problems with perception. To help ease the transition and study the effects of weightlessness on the body, NASA has conducted many investigations into post-flight balance control, realizing this research can help treat patients with balance disorders on Earth as well. In the 1960s, the NASA-sponsored Man Vehicle Laboratory at the Massachusetts Institute of Technology (MIT) studied the effects of prolonged space flight on astronauts. The lab s work intrigued MIT doctoral candidate Lewis Nashner, who began conducting NASA-funded research on human movement and balance under the supervision of Dr. Larry Young in the MIT Department of Aeronautics and Astronautics. In 1982, Nashner s work resulted in a noninvasive clinical technique for assessing the cooperative systems that allow the body to balance, commonly referred to as computerized dynamic posturography (CDP). CDP employs a series of dynamic protocols to isolate and assess balance function deficiencies. The technology was based on Nashner s novel, engineering-inspired concept of balance as an adaptable collaboration between multiple sensory and motor systems. CDP proved useful not only for examining astronauts, but for anyone suffering from balance problems. Today, CDP is the standard medical tool for objectively evaluating balance control.

Asteroid Exploration and Exploitation

NASA Technical Reports Server (NTRS)

Lewis, John S.

2006-01-01

John S. Lewis is Professor of Planetary Sciences and Co-Director of the Space Engineering Research Center at the University of Arizona. He was previously a Professor of Planetary Sciences at MIT and Visiting Professor at the California Institute of Technology. Most recently, he was a Visiting Professor at Tsinghua University in Beijing for the 2005-2006 academic year. His research interests are related to the application of chemistry to astronomical problems, including the origin of the Solar System, the evolution of planetary atmospheres, the origin of organic matter in planetary environments, the chemical structure and history of icy satellites, the hazards of comet and asteroid bombardment of Earth, and the extraction, processing, and use of the energy and material resources of nearby space. He has served as member or Chairman of a wide variety of NASA and NAS advisory committees and review panels. He has written 17 books, including undergraduate and graduate level texts and popular science books, and has authored over 150 scientific publications.

Light Weight Portable Plasma Medical Device - Plasma Engineering Research Laboratory

DTIC Science & Technology

2011-10-01

Millennial Student. 15. Thiyagarajan, M. (2011). Portable Plasma Biomedical Device for Cancer Treatment. Irvine, California: ASME Emerging...American Society of Mechanical Engineers Sigma Xi Toastmasters International Club MIT Entrepreneur Club Eta Kappa Nu Tau Beta Pi Institute of...Learning Environment. Corpus Christi, TX: TAMUCC 1st Faculty Symposium: Course Design for the Millennial Student. Thiyagarajan, M. (2011). Portable

Microgravity

NASA Image and Video Library

2001-05-15

Lisa Freed and Gordana Vunjak-Novakovic, both of the Massachusetts Institute of Technology (MIT), have taken the first steps toward engineering heart muscle tissue that could one day be used to patch damaged human hearts. Cells isolated from very young animals are attached to a three-dimensional polymer scaffold, then placed in a NASA bioreactor. The cells do not divide, but after about a week start to cornect to form a functional piece of tissue. Functionally connected heart cells that are capable of transmitting electrical signals are the goal for Freed and Vunjak-Novakovic. Electrophysiological recordings of engineered tissue show spontaneous contractions at a rate of 70 beats per minute (a), and paced contractions at rates of 80, 150, and 200 beats per minute respectively (b, c, and d). The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). Credit: NASA and MIT.

Microgravity

NASA Image and Video Library

2001-05-15

Lisa Freed and Gordana Vunjak-Novakovic, both of the Massachusetts Institute of Technology (MIT), have taken the first steps toward engineering heart muscle tissue that could one day be used to patch damaged human hearts. Cells isolated from very young animals are attached to a three-dimensional polymer scaffold, then placed in a NASA bioreactor. The cells do not divide, but after about a week start to cornect to form a functional piece of tissue. Here, a transmission electron micrograph of engineered tissue shows a number of important landmarks present in functional heart tissue: (A) well-organized myofilaments (Mfl), z-lines (Z), and abundant glycogen granules (Gly); and (D) intercalcated disc (ID) and desmosomes (DES). The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). Credit: MIT

Heart tissue grown in NASA Bioreactor

NASA Technical Reports Server (NTRS)

2001-01-01

Lisa Freed and Gordana Vunjak-Novakovic, both of the Massachusetts Institute of Technology (MIT), have taken the first steps toward engineering heart muscle tissue that could one day be used to patch damaged human hearts. Cells isolated from very young animals are attached to a three-dimensional polymer scaffold, then placed in a NASA bioreactor. The cells do not divide, but after about a week start to cornect to form a functional piece of tissue. Here, a transmission electron micrograph of engineered tissue shows a number of important landmarks present in functional heart tissue: (A) well-organized myofilaments (Mfl), z-lines (Z), and abundant glycogen granules (Gly); and (D) intercalcated disc (ID) and desmosomes (DES). The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). Credit: MIT

Heart tissue grown in NASA Bioreactor

NASA Technical Reports Server (NTRS)

2001-01-01

Lisa Freed and Gordana Vunjak-Novakovic, both of the Massachusetts Institute of Technology (MIT), have taken the first steps toward engineering heart muscle tissue that could one day be used to patch damaged human hearts. Cells isolated from very young animals are attached to a three-dimensional polymer scaffold, then placed in a NASA bioreactor. The cells do not divide, but after about a week start to cornect to form a functional piece of tissue. Functionally connected heart cells that are capable of transmitting electrical signals are the goal for Freed and Vunjak-Novakovic. Electrophysiological recordings of engineered tissue show spontaneous contractions at a rate of 70 beats per minute (a), and paced contractions at rates of 80, 150, and 200 beats per minute respectively (b, c, and d). The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). Credit: NASA and MIT.

Lab architecture

NASA Astrophysics Data System (ADS)

Crease, Robert P.

2008-04-01

There are few more dramatic illustrations of the vicissitudes of laboratory architecturethan the contrast between Building 20 at the Massachusetts Institute of Technology (MIT) and its replacement, the Ray and Maria Stata Center. Building 20 was built hurriedly in 1943 as temporary housing for MIT's famous Rad Lab, the site of wartime radar research, and it remained a productive laboratory space for over half a century. A decade ago it was demolished to make way for the Stata Center, an architecturally striking building designed by Frank Gehry to house MIT's computer science and artificial intelligence labs (above). But in 2004 - just two years after the Stata Center officially opened - the building was criticized for being unsuitable for research and became the subject of still ongoing lawsuits alleging design and construction failures.

Final Report: Quantification of Uncertainty in Extreme Scale Computations (QUEST)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marzouk, Youssef; Conrad, Patrick; Bigoni, Daniele

QUEST (\\url{www.quest-scidac.org}) is a SciDAC Institute that is focused on uncertainty quantification (UQ) in large-scale scientific computations. Our goals are to (1) advance the state of the art in UQ mathematics, algorithms, and software; and (2) provide modeling, algorithmic, and general UQ expertise, together with software tools, to other SciDAC projects, thereby enabling and guiding a broad range of UQ activities in their respective contexts. QUEST is a collaboration among six institutions (Sandia National Laboratories, Los Alamos National Laboratory, the University of Southern California, Massachusetts Institute of Technology, the University of Texas at Austin, and Duke University) with a historymore » of joint UQ research. Our vision encompasses all aspects of UQ in leadership-class computing. This includes the well-founded setup of UQ problems; characterization of the input space given available data/information; local and global sensitivity analysis; adaptive dimensionality and order reduction; forward and inverse propagation of uncertainty; handling of application code failures, missing data, and hardware/software fault tolerance; and model inadequacy, comparison, validation, selection, and averaging. The nature of the UQ problem requires the seamless combination of data, models, and information across this landscape in a manner that provides a self-consistent quantification of requisite uncertainties in predictions from computational models. Accordingly, our UQ methods and tools span an interdisciplinary space across applied math, information theory, and statistics. The MIT QUEST effort centers on statistical inference and methods for surrogate or reduced-order modeling. MIT personnel have been responsible for the development of adaptive sampling methods, methods for approximating computationally intensive models, and software for both forward uncertainty propagation and statistical inverse problems. A key software product of the MIT QUEST effort is the MIT Uncertainty Quantification library, called MUQ (\\url{muq.mit.edu}).« less

What have we learned in ITS?

DOT National Transportation Integrated Search

2000-04-01

This presentation was given by Prof. Joseph M. Sussman of MIT during the closing plenary session of the Institute of Transportation Engineers 2000 Conference entitled "Transportation Operations - Moving into the 21st Century" on April 5, 2000 in Irvi...

Educational Outreach at the M.I.T. Plasma Fusion Center

NASA Astrophysics Data System (ADS)

Censabella, V.

1996-11-01

Educational outreach at the MIT Plasma Fusion Center consists of volunteers working together to increase the public's knowledge of fusion and plasma-related experiments. Seeking to generate excitement about science, engineering and mathematics, the PFC holds a number of outreach activities throughout the year, such as Middle and High School Outreach Days. Outreach also includes the Mr. Magnet Program, which uses an interactive strategy to engage elementary school children. Included in this year's presentation will be a new and improved C-MOD Jr, a confinement video game which helps students to discover how computers manipulate magnetic pulses to keep a plasma confined for as long as possible. Also on display will be an educational toy created by the Cambridge Physics Outlet, a PFC spin-off company. The PFC maintains a Home Page on the World Wide Web, which can be reached at http://cmod2.pfc.mit.edu/.

Neutral Buoyancy Simulator-NB32-Assembly of Large Space Structure

NASA Technical Reports Server (NTRS)

1980-01-01

Once the United States' space program had progressed from Earth's orbit into outerspace, theprospect of building and maintaining a permanent presence in space was realized. To accomplish this feat, NASA launched a temporary workstation, Skylab, to discover the effects of low gravity and weightlessness on the human body, and also to develop tools and equipment that would be needed in the future to build and maintain a more permanent space station. The structures, techniques, and work schedules had to be carefully designed to fit this unique construction site. The components had to be lightweight for transport into orbit, yet durable. The station also had to be made with removable parts for easy servicing and repairs by astronauts. All of the tools necessary for service and repairs had to be designed for easy manipulation by a suited astronaut. Construction methods had to be efficient due to the limited time the astronauts could remain outside their controlled environment. In lieu of all the specific needs for this project, an environment on Earth had to be developed that could simulate a low gravity atmosphere. A Neutral Buoyancy Simulator (NBS) was constructed by NASA's Marshall Space Flight Center (MSFC) in 1968. Since then, NASA scientists have used this facility to understand how humans work best in low gravity and also provide information about the different kinds of structures that can be built. Pictured is a Massachusetts Institute of Technology (MIT) student working in a spacesuit on the Experimental Assembly of Structures in Extravehicular Activity (EASE) project which was developed as a joint effort between MFSC and MIT. The EASE experiment required that crew members assemble small components to form larger components, working from the payload bay of the space shuttle. The MIT student in this photo is assembling two six-beam tetrahedrons.

Stellar Interferometer Technology Experiment (SITE)

NASA Technical Reports Server (NTRS)

Crawley, Edward F.; Miller, David; Laskin, Robert; Shao, Michael

1995-01-01

The MIT Space Engineering Research Center and the Jet Propulsion Laboratory stand ready to advance science sensor technology for discrete-aperture astronomical instruments such as space-based optical interferometers. The objective of the Stellar Interferometer Technology Experiment (SITE) is to demonstrate system-level functionality of a space-based stellar interferometer through the use of enabling and enhancing Controlled-Structures Technologies (CST). SITE mounts to the Mission Peculiar Experiment Support System inside the Shuttle payload bay. Starlight, entering through two apertures, is steered to a combining plate where it is interferred. Interference requires 27 nanometer pathlength (phasing) and 0.29 archsecond wavefront-tilt (pointing) control. The resulting 15 milli-archsecond angular resolution exceeds that of current earth-orbiting telescopes while maintaining low cost by exploiting active optics and structural control technologies. With these technologies, unforeseen and time-varying disturbances can be rejected while relaxing reliance on ground alignment and calibration. SITE will reduce the risk and cost of advanced optical space systems by validating critical technologies in their operational environment. Moreover, these technologies are directly applicable to commercially driven applications such as precision matching, optical scanning, and vibration and noise control systems for the aerospace, medical, and automotive sectors. The SITE team consists of experienced university, government, and industry researchers, scientists, and engineers with extensive expertise in optical interferometry, nano-precision opto-mechanical control and spaceflight experimentation. The experience exists and the technology is mature. SITE will validate these technologies on a functioning interferometer science sensor in order to confirm definitely their readiness to be baselined for future science missions.

La Vida Robot - High School Engineering Program Combats Engineering Brain Drain

ScienceCinema

Cameron, Allan; Lajvardi, Fredi

2018-05-04

Carl Hayden High School has built an impressive reputation with its robotics club. At a time when interest in science, math and engineering is declining, the Falcon Robotics club has young people fired up about engineering. Their program in underwater robots (MATE) and FIRST robotics is becoming a national model, not for building robots, but for building engineers. Teachers Fredi Lajvardi and Allan Cameron will present their story (How kids 'from the mean streets of Phoenix took on the best from M.I.T. in the national underwater bot championship' - Wired Magazine, April 2005) and how every student needs the opportunity to 'do real engineering.'

Aeromedical Lessons from the Space Shuttle Columbia Accident Investigation

NASA Technical Reports Server (NTRS)

Pool, Sam L.

2005-01-01

This paper presents the aeromedical lessons learned from the Space Shuttle Columbia Accident Investigation. The contents include: 1) Introduction and Mission Response Team (MRT); 2) Primary Disaster Field Office (DFO); 3) Mishap Investigation Team (MIT); 4) Kennedy Space Center (KSC) Mishap Response Plan; 5) Armed Forces Institute of Pathology (AFIP); and 6) STS-107 Crew Surgeon.

Building Technological Capability within Satellite Programs in Developing Countries

NASA Astrophysics Data System (ADS)

Wood, Danielle Renee

Global participation in space activity is growing as satellite technology matures and spreads. Countries in Africa, Asia and Latin America are creating or reinvigorating national satellite programs. These countries are building local capability in space through technological learning. They sometimes pursue this via collaborative satellite development projects with foreign firms that provide training. This phenomenon of collaborative satellite development projects is poorly understood by researchers of technological learning and technology transfer. The approach has potential to facilitate learning, but there are also challenges due to misaligned incentives and the tacit nature of the technology. Perspectives from literature on Technological Learning, Technology Transfer, Complex Product Systems and Product Delivery provide useful but incomplete insight for decision makers in such projects. This work seeks a deeper understanding of capability building through collaborative technology projects by conceiving of the projects as complex, socio-technical systems with architectures. The architecture of a system is the assignment of form to execute a function along a series of dimensions. The research questions explore the architecture of collaborative satellite projects, the nature of capability building during such projects, and the relationship between architecture and capability building. The research design uses inductive, exploratory case studies to investigate six collaborative satellite development projects. Data collection harnesses international field work driven by interviews, observation, and documents. The data analysis develops structured narratives, architectural comparison and capability building assessment. The architectural comparison reveals substantial variation in project implementation, especially in the areas of project initiation, technical specifications of the satellite, training approaches and the supplier selection process. The individual capability building assessment shows that most trainee engineers gradually progressed from no experience with satellites through theoretical training to supervised experience; a minority achieved independent experience. At the organizational level, the emerging space organizations achieved high levels of autonomy in project definition and satellite operation, but they were dependent on foreign firms for satellite design, manufacture, test and launch. The case studies can be summarized by three archetypal projects defined as "Politically Pushed," "Structured," and "Risk Taking." Countries in the case studies tended to start in a Politically Pushed mode, and then moved into either Structured or Risk Taking mode. Decision makers in emerging satellite programs can use the results of this dissertation to consider the broad set of architectural options for capability building. Future work will continue to probe how specific architectural decisions impact capability building outcomes in satellite projects and other technologies. (Copies available exclusively from MIT Libraries, libraries.mit.edu/docs - docs@mit.edu)

Around Marshall

NASA Image and Video Library

1980-01-07

Once the United States' space program had progressed from Earth's orbit into outerspace, the prospect of building and maintaining a permanent presence in space was realized. To accomplish this feat, NASA launched a temporary workstation, Skylab, to discover the effects of low gravity and weightlessness on the human body, and also to develop tools and equipment that would be needed in the future to build and maintain a more permanent space station. The structures, techniques, and work schedules had to be carefully designed to fit this unique construction site. The components had to be lightweight for transport into orbit, yet durable. The station also had to be made with removable parts for easy servicing and repairs by astronauts. All of the tools necessary for service and repairs had to be designed for easy manipulation by a suited astronaut. Construction methods had to be efficient due to the limited time the astronauts could remain outside their controlled environment. In lieu of all the specific needs for this project, an environment on Earth had to be developed that could simulate a low gravity atmosphere. A Neutral Buoyancy Simulator (NBS) was constructed by NASA's Marshall Space Flight Center (MSFC) in 1968. Since then, NASA scientists have used this facility to understand how humans work best in low gravity and also provide information about the different kinds of structures that can be built. Pictured is a Massachusetts Institute of Technology (MIT) student working in a spacesuit on the Experimental Assembly of Structures in Extravehicular Activity (EASE) project which was developed as a joint effort between MFSC and MIT. The EASE experiment required that crew members assemble small components to form larger components, working from the payload bay of the space shuttle. The MIT student in this photo is assembling two six-beam tetrahedrons.

Around Marshall

NASA Image and Video Library

1980-02-27

Once the United States' space program had progressed from Earth's orbit into outerspace, theprospect of building and maintaining a permanent presence in space was realized. To accomplish this feat, NASA launched a temporary workstation, Skylab, to discover the effects of low gravity and weightlessness on the human body, and also to develop tools and equipment that would be needed in the future to build and maintain a more permanent space station. The structures, techniques, and work schedules had to be carefully designed to fit this unique construction site. The components had to be lightweight for transport into orbit, yet durable. The station also had to be made with removable parts for easy servicing and repairs by astronauts. All of the tools necessary for service and repairs had to be designed for easy manipulation by a suited astronaut. Construction methods had to be efficient due to the limited time the astronauts could remain outside their controlled environment. In lieu of all the specific needs for this project, an environment on Earth had to be developed that could simulate a low gravity atmosphere. A Neutral Buoyancy Simulator (NBS) was constructed by NASA's Marshall Space Flight Center (MSFC) in 1968. Since then, NASA scientists have used this facility to understand how humans work best in low gravity and also provide information about the different kinds of structures that can be built. Pictured is a Massachusetts Institute of Technology (MIT) student working in a spacesuit on the Experimental Assembly of Structures in Extravehicular Activity (EASE) project which was developed as a joint effort between MFSC and MIT. The EASE experiment required that crew members assemble small components to form larger components, working from the payload bay of the space shuttle. The MIT student in this photo is assembling two six-beam tetrahedrons.

Updating the NASA LEO Orbital Debris Environment Model with Recent Radar and Optical Observations and in Situ Measurements

NASA Technical Reports Server (NTRS)

Liou, J.-C.; Anz-Meador, P.; Matney, M. J.; Kessler, D. J.; Theall, J.; Johnson, N. L.

2000-01-01

The Low Earth Orbit (LEO, between 200 and 2000 km altitudes) debris environment has been constantly measured by NASA Johnson Space Center's Liquid Mirror Telescope (LMT) since 1996 (Africano et al. 1999, NASA JSC-28826) and by Haystack and Haystack Auxiliary radars at MIT Lincoln Laboratory since 1990 (Settecerri et al. 1999, NASA JSC-28744). Debris particles as small as 3 mm can be detected by the radars and as small as 3 cm can be measured by LMT. Objects about 10 cm in diameter and greater are tracked and catalogued by the US Space Surveillance Network. Much smaller (down to several micrometers) natural and debris particle populations can be estimated based on in situ measurements, such as Long Duration Exposure Facility, and based on analyses of returned surfaces, such as Hubble Space Telescope solar arrays, European Retrievable Carrier, and Space Shuttles. To increase our understanding of the current LEO debris environment, the Orbital Debris Program Office at NASA JSC has initiated an effort to improve and update the ORDEM96 model (Kessler et al. 1996, NASA TM-104825) utilizing the recently available data. This paper gives an overview of the new NASA orbital debris engineering model, ORDEM2000.

The University: Marketing Theories, Not Toothpaste.

ERIC Educational Resources Information Center

Krimsky, Sheldon

1982-01-01

Using genetic engineering as an example, issues related to functions of universities/industry and scientific research are discussed. A research agreement between MIT and Exxon Corporation (on combustion science) is outlined, addressing issues related to such agreements (including patents/patent ownership and publications). Suggests future…

High Gradient Accelerator Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Temkin, Richard

The goal of the MIT program of research on high gradient acceleration is the development of advanced acceleration concepts that lead to a practical and affordable next generation linear collider at the TeV energy level. Other applications, which are more near-term, include accelerators for materials processing; medicine; defense; mining; security; and inspection. The specific goals of the MIT program are: • Pioneering theoretical research on advanced structures for high gradient acceleration, including photonic structures and metamaterial structures; evaluation of the wakefields in these advanced structures • Experimental research to demonstrate the properties of advanced structures both in low-power microwave coldmore » test and high-power, high-gradient test at megawatt power levels • Experimental research on microwave breakdown at high gradient including studies of breakdown phenomena induced by RF electric fields and RF magnetic fields; development of new diagnostics of the breakdown process • Theoretical research on the physics and engineering features of RF vacuum breakdown • Maintaining and improving the Haimson / MIT 17 GHz accelerator, the highest frequency operational accelerator in the world, a unique facility for accelerator research • Providing the Haimson / MIT 17 GHz accelerator facility as a facility for outside users • Active participation in the US DOE program of High Gradient Collaboration, including joint work with SLAC and with Los Alamos National Laboratory; participation of MIT students in research at the national laboratories • Training the next generation of Ph. D. students in the field of accelerator physics.« less

La Vida Robot - High School Engineering Program Combats Engineering Brain Drain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cameron, Allan; Lajvardi, Fredi

Carl Hayden High School has built an impressive reputation with its robotics club. At a time when interest in science, math and engineering is declining, the Falcon Robotics club has young people fired up about engineering. Their program in underwater robots (MATE) and FIRST robotics is becoming a national model, not for building robots, but for building engineers. Teachers Fredi Lajvardi and Allan Cameron will present their story (How kids 'from the mean streets of Phoenix took on the best from M.I.T. in the national underwater bot championship' - Wired Magazine, April 2005) and how every student needs the opportunitymore » to 'do real engineering.'« less

Rethinking the Relationship Between Academia and Industry: Qualitative Case Studies of MIT and Stanford.

PubMed

Zhu, Fengliang; Hawk, Soaring

2016-10-01

As knowledge has become more closely tied to economic development, the interrelationship between academia and industry has become stronger. The result has been the emergence of what Slaughter and Leslie call academic capitalism. Inevitably, tensions between academia and industry arise; however, universities such as MIT and Stanford with long traditions of industry interaction have been able to achieve a balance between academic and market values. This paper describes the strategies adopted by MIT and Stanford to achieve this balance. The results indicate that implicit culture is a stronger determinant of balance than are explicit rules. Finally, the author proposes a concept of balance to reconsider the relationship between academia and industry: today's universities, particularly those with strengths in engineering and management, are both symbiotic and interdependent with industry. A reasonable attitude toward the university-industry relationship is that of balance rather than strict separation. Universities can thus establish effective mechanisms to reach a balance between conflicting values.

Sticktechnologie für medizinische Textilien und Tissue Engineering

NASA Astrophysics Data System (ADS)

Karamuk, Erdal; Mayer, Jörg; Wintermantel, Erich

Textile Strukturen werden in grossem Ausmass als medizinische Implantate eingesetzt, um Weich- und Hartgewebe zu unterstützen oder zu ersetzen. Im Tissue Engineering gewinnen sie an Bedeutung als scaffolds, um biologische Gewebe in vitro zu züchten für anschliessende Implantation oder extrakorporale Anwendungen. Textilien sind gewöhnlich anisotrope zweidimensionale Strukturen mit hoher Steifigkeit in der Ebene und geringer Biegesteifigkeit. Durch eine Vielzahl textiler Prozesse und durch entsprechende Wahl des Fasermaterials ist es möglich, Oberfläche, Porosität und mechanische Anisotropie in hohem Masse zu variieren. Wegen ihrer einzigartigen strukturellen und mechanischen Eigenschaften können faserbasierte Materialien in weitem Masse biologischem Gewebe nachgeahmt werden [1]. Gesticke erweitern das Feld von technischen und besonders medizinischen Textilien, denn sie vereinen sehr hohe strukturelle Variabilität mit der Möglichkeit, mechanische Eigenschaften in einem grossen Bereich einzustellen, um so die mechanischen Anforderungen des Empfängergewebes zu erfüllen (Abb. 42.1).

PI in the sky: The astronaut science advisor on SLS-2

NASA Technical Reports Server (NTRS)

Hazelton, Lyman R.; Groleau, Nicolas; Frainier, Richard J.; Compton, Michael M.; Colombano, Silvano P.; Szolovits, Peter

1994-01-01

The Astronaut Science Advisor (ASA, also known as Principal-Investigator-in-a-Box) is an advanced engineering effort to apply expert systems technology to experiment monitoring and control. Its goal is to increase the scientific value of information returned from experiments on manned space missions. The first in-space test of the system will be in conjunction with Professor Larry Young's (MIT) vestibulo-ocular 'Rotating Dome' experiment on the Spacelab Life Sciences 2 mission (STS-58) in the Fall of 1993. In a cost-saving effort, off-the-shelf equipment was employed wherever possible. Several modifications were necessary in order to make the system flight-worthy. The software consists of three interlocking modules. A real-time data acquisition system digitizes and stores all experiment data and then characterizes the signals in symbolic form; a rule-based expert system uses the symbolic signal characteristics to make decisions concerning the experiment; and a highly graphic user interface requiring a minimum of user intervention presents information to the astronaut operator. Much has been learned about the design of software and user interfaces for interactive computing in space. In addition, we gained a great deal of knowledge about building relatively inexpensive hardware and software for use in space. New technologies are being assessed to make the system a much more powerful ally in future scientific research in space and on the ground.

Transiting Exoplanet Survey Satellite (TESS) Briefing

NASA Image and Video Library

2018-03-28

George Ricker, TESS principal investigator, MIT Kavli Institute for Astrophysics and Space Research, left, and Jeff Volosin, TESS project manager, NASA’s Goddard Space Flight Center, discuss the upcoming launch of NASA’s next planet hunter, the Transiting Exoplanet Survey Satellite (TESS), Wednesday, March 28, 2018 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

Transiting Exoplanet Survey Satellite (TESS) Briefing

NASA Image and Video Library

2018-03-28

George Ricker, TESS principal investigator, MIT Kavli Institute for Astrophysics and Space Research, left, and Jeff Volosin, TESS project manager, NASA’s Goddard Space Flight Center discuss the upcoming launch of NASA’s next planet hunter, the Transiting Exoplanet Survey Satellite (TESS), Wednesday, March 28, 2018 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

Medical Response, Search and Recovery during the Space Shuttle Columbia Accident Investigation

NASA Technical Reports Server (NTRS)

Stepaniak, Philip C.

2010-01-01

On February 1, 2003, the Space Shuttle Columbia broke apart during atmospheric re-entry on mission STS-107. After an event such as this, with high visibility and international interest, the operational challenge of recovering the crewmembers could not be underestimated. The Space Shuttle Program is organized to respond to a vehicle mishap using the resources of the Mishap Investigation Team (MIT). On the afternoon of Feb. 1, 2003, the MIT deployed to Barksdale Air Force Base (AFB), Louisiana. This location became the investigative center and interim storage location for crewmembers received from the Lufkin, Texas Disaster Field Office (DFO). The Lufkin DFO served as the primary area for all operations, including staging assets and deploying field teams for search, recovery and security of crewmember remains. More than 2,000 people from numerous organizations were involved with the recovery of the crew. All seven crewmembers of STS-107 were recovered and ceremonial last rights were administered. Astronaut and military personnel escorted the crew with honor to the MIT at Barksdale AFB, Louisiana. At Barksdale AFB a temporary morgue was established in an aircraft hangar and operated for approximately two weeks during which time coordination with the DFO field recovery teams, Armed Forces Institute of Pathology (AFIP) medical personnel, and the crew surgeons was on going. Families of crewmembers and NASA management were notified daily of the current findings. Working under the leadership of the MIT Lead, the medical team developed and executed a short-term plan to identify and relocate the crew with a military honor guard and protocol to the medical examiner at the Armed Forces Port Mortuary, Dover AFB, Delaware. After operations at Barksdale AFB were concluded the medical team transitioned back to Houston and a long-term plan was developed and implemented which involved the Air Force Mortuary Affairs at Randolph AFB, Texas. This plan was coordinated with search teams in the field, Barksdale AFB Mortuary Affairs, KSC security, AFIP, and the crew surgeons at JSC.

Dataflow Architectures.

DTIC Science & Technology

1986-02-12

of Electrical Engineering and Computer Science. MIT, Cambridge, MA,June 1983. 33. Hiraki , K.. K. Nishida and T. Shimada. "Evaluation of Associative...J. R. Gurd. "A Practical Dataflow Computer". Computer 15,2 (February 1982), 51-57. 50. Yuba, T., T. Shimada, K. Hiraki , and H. Kashiwagi. Sigma-i: A

On Directionality of Phrase Structure Building

ERIC Educational Resources Information Center

Chesi, Cristiano

2015-01-01

Minimalism in grammatical theorizing (Chomsky in "The minimalist program." MIT Press, Cambridge, 1995) led to simpler linguistic devices and a better focalization of the core properties of the structure building engine: a lexicon and a free (recursive) phrase formation operation, dubbed Merge, are the basic components that serve in…

Production Engineering for Growth of Synthetic Calcite Polarizer Material

DTIC Science & Technology

1974-08-01

AD-A008 043 PRODUCTION ENGINEERING FOR GROWTH OF SYNTHETIC CALCITE POLARIZER MATERIAL Roger F. Belt, et al Litton Systems...Production Bngin««ring for Growth of Synthetic Calcit « Polarizer Material I. RCCIPItNT’tCATALOO NUMMN i. T.vpc or ncpoMT • rtmoo covtnto Final Report...VOKOt (CanlliMit en »xift •id« II ntffrt Kid Idtnlllr br block iwmbmr) Crystal Growth Hydrothermal Growth Calcite Polarizers 30. AtSTHACT

Cost Analysis of Utilizing Electric Vehicles and Photovoltaic Solar Energy in the United States Marine Corps Commercial Vehicle Fleet

DTIC Science & Technology

2009-12-01

vehicles so do some electric vehicle braking systems (MIT, 2008). e. Brakes Regenerative braking on electric vehicles recoups some of the energy lost...engine is required to replace the energy lost by braking . Regenerative braking takes some of the lost energy during braking and turns it into...Motors and Tesla Motors offer regenerative breaking in their respective electric vehicles. Tesla explains regenerative braking as “engine braking

President Gerald Ford holds crystal manufactured in space during Skylab 4

NASA Technical Reports Server (NTRS)

1974-01-01

President Gerald R. Ford, center, holds encased crystal manufactured in space during Skylab 4. Dr. James C. Fletcher, left, NASA Administrator, explains the article to the Chief Executive as Dr. Harold Johnson of M.I.T. looks on. The indium-antimonide crystal was formed in Earth orbit on January 6, 1974, by the Skylab 4 astronauts.

Manual Training Schools in America.

ERIC Educational Resources Information Center

Schenck, John P.

John Runkle, president of the Massachusetts Institute of Technology (MIT), viewed the Moscow Imperial Technical School exhibit at the Philadelphia Centennial Exposition of 1876 and saw the Russian method of manual training as the answer to the dilemma of combining theory and practice in engineering instruction. On August 17, 1876, shops in which…

Not Your Grandparents' Vocational School

ERIC Educational Resources Information Center

Schachter, Ron

2012-01-01

Manufacturing biodiesel fuel, building a geodesic-domed greenhouse, measuring the environmental impact of abandoned industrial canals--these might well fit the mission of cutting-edge companies specializing in green technologies, or they could be part of the curriculum at an institution of advanced science and engineering such as MIT or Cal Tech.…

Haystack Ultrawideband Satellite Imaging Radar

DTIC Science & Technology

2014-09-01

SEP 2014 2. REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE Haystack Ultrawideband Satellite Imaging Radar 5a...www.ll.mit.edu September 2014 Since the launch of satellites into Earth orbits more than 50 years ago, space has become crowded. Commercial and military... satellites , both active and defunct, share the space environment with an assort- ment of space debris, such as remnants of damaged spacecraft and

TESS Ground System Operations and Data Products

NASA Astrophysics Data System (ADS)

Glidden, Ana; Guerrero, Natalia; Fausnaugh, Michael; TESS Team

2018-01-01

We describe the ground system operations for processing data from the Transiting Exoplanet Survey Satellite (TESS), highlighting the role of the Science Operations Center (SOC). TESS is a spaced-based (nearly) all-sky mission, designed to find small planets around nearby bright stars using the transit method. We detail the flow of data from pixel measurements on the instrument to final products available at the Mikulski Archive for Space Telescopes (MAST). The ground system relies on a host of players to process the data, including the Payload Operations Center at MIT, the Science Processing Operation Center at NASA Ames, and the TESS Science Office, led by the Harvard-Smithsonian Center for Astrophysics and MIT. Together, these groups will deliver TESS Input Catalog, instrument calibration models, calibrated target pixels and full frame images, threshold crossing event reports, two-minute light curves, and the TESS Objects of Interest List.

2011 Presidential Early Career Awards for Scientists and Engineers: the PECASE Awards Ceremony

ScienceCinema

Poneman, Daniel

2018-05-31

The winners for 2011 of the DOE PECASE Awards were recognized in a ceremony held August 01, 2012. Dr. Bill Brinkman, Director of the Office of Science introduced the main speaker, DOE Deputy Secretary Daniel B. Poneman. Leaders from across the Department and the fields of energy research and technology presented the 2011 winners. They are: Dr. Stanley Atcitty (SNL); Dr. Jeffrey W. Banks (LLNL); Dr. Amy J. Clarke (LANL); Derek R. Gaston (INL); Dr. Christopher Hirata (California Institute of Technology); Dr. Heileen Hsu-Kim (Duke University); Dr. Thomas Francisco (Jaramillo Stanford University); Dr.Pablo Jarillo-Herrero (MIT); Dr. Peter Mueller (ANL); Dr. Daniel B. Sinars (SNL); Dr. Jesse Thaler (MIT); and Dr. Heather Whitley (LLNL).

2011 Presidential Early Career Awards for Scientists and Engineers: the PECASE Awards Ceremony

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poneman, Daniel

2012-08-01

The winners for 2011 of the DOE PECASE Awards were recognized in a ceremony held August 01, 2012. Dr. Bill Brinkman, Director of the Office of Science introduced the main speaker, DOE Deputy Secretary Daniel B. Poneman. Leaders from across the Department and the fields of energy research and technology presented the 2011 winners. They are: Dr. Stanley Atcitty (SNL); Dr. Jeffrey W. Banks (LLNL); Dr. Amy J. Clarke (LANL); Derek R. Gaston (INL); Dr. Christopher Hirata (California Institute of Technology); Dr. Heileen Hsu-Kim (Duke University); Dr. Thomas Francisco (Jaramillo Stanford University); Dr.Pablo Jarillo-Herrero (MIT); Dr. Peter Mueller (ANL); Dr.more » Daniel B. Sinars (SNL); Dr. Jesse Thaler (MIT); and Dr. Heather Whitley (LLNL).« less

Educational Outreach at the MIT Plasma Science and Fusion Center

NASA Astrophysics Data System (ADS)

Rivenberg, Paul; Thomas, Paul

2004-11-01

At the MIT PSFC student and staff volunteers work together to increase the public's knowledge of fusion science and plasma technology. Seeking to generate excitement in young people about science and engineering, the PSFC hosts a number of educational outreach activities and tours throughout the year, including Middle and High School Outreach Days. The PSFC also has an in-school science demonstration program on the theme of magnetism. As ''Mr. Magnet'' Technical Supervisor Paul Thomas brings a truck-load of hands-on demonstrations to K-12 schools, challenging students to help him with experiments. While teaching fundamentals of magnetism and electricity he shows that science is fun for all, and that any student can have a career in science. This year he taught at 75 schools and other events, reaching 30,000 teachers and students. He has expanded his teaching to include an interactive demonstration of plasma, encouraging participants to investigate plasma properties with audiovisual, electromagnetic, and spectroscopic techniques. The PSFC's continuing involvement with the MIT Museum and the Boston Museum of Science also helps familiarize the public with the fourth state of matter.

Engineering and Physics Optimization of Breed and Burn Fast Reactor Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michael J. Driscoll; Pavel Hejzlar; Peter Yarsky

2005-12-09

This project is organized under four major tasks (each of which has two or more subtasks) with contributions among the three collaborating organizations (MIT, INEEL and ANL-West): Task A: Core Physics and Fuel Cycle; Task B: Core Thermal Hydraulics; Task C: Plant Design Task; and D: Fuel Design.

Going Up

NASA Technical Reports Server (NTRS)

Douglas, Freddie, III

2004-01-01

The accelerated Leadership Option (ALO) combines business management and systems engineering studies at the Massachusetts Institute of Technology (MIT) culminating in a Master of Science degree, with a one year developmental assignment. The program accelerates the development process of exceptionally promising project leaders to positions of increased responsibility. Participants are selected because of technical expertise and proven leadership abilities.

NREL: News - Technology Review Honors National Renewable Energy Lab

Science.gov Websites

Engineer as One of the World's Top Young Innovators Technology Review Honors National Renewable Technology Magazine Golden, Colo., May 20, 2002 The U.S. Department of Energy's National Renewable Energy Systems, has been chosen as one of the world's 100 Top Young Innovators by Technology Review, MIT's

Digging Out of the Digital Divide

ERIC Educational Resources Information Center

Galuszka, Peter

2007-01-01

One of the most prominent engineers and entrepreneurs in the country, Dr. Randal D. Pinkett keeps a high profile on issues related to minorities, technology and education. The holder of five degrees, Pinkett has built an academic record that includes a doctorate and MBA from the Massachusetts Institute of Technology (MIT). He was also named a…

Design of an algorithm for autonomous docking with a freely tumbling target

NASA Astrophysics Data System (ADS)

Nolet, Simon; Kong, Edmund; Miller, David W.

2005-05-01

For complex unmanned docking missions, limited communication bandwidth and delays do not allow ground operators to have immediate access to all real-time state information and hence prevent them from playing an active role in the control loop. Advanced control algorithms are needed to make mission critical decisions to ensure safety of both spacecraft during close proximity maneuvers. This is especially true when unexpected contingencies occur. These algorithms will enable multiple space missions, including servicing of damaged spacecraft and missions to Mars. A key characteristic of spacecraft servicing missions is that the target spacecraft is likely to be freely tumbling due to various mechanical failures or fuel depletion. Very few technical references in the literature can be found on autonomous docking with a freely tumbling target and very few such maneuvers have been attempted. The MIT Space Systems Laboratory (SSL) is currently performing research on the subject. The objective of this research is to develop a control architecture that will enable safe and fuel-efficient docking of a thruster based spacecraft with a freely tumbling target in presence of obstacles and contingencies. The approach is to identify, select and implement state estimation, fault detection, isolation and recovery, optimal path planning and thruster management algorithms that, once properly integrated, can accomplish such a maneuver autonomously. Simulations and demonstrations on the SPHERES testbed developed by the MIT SSL will be executed to assess the performance of different combinations of algorithms. To date, experiments have been carried out at the MIT SSL 2-D Laboratory and at the NASA Marshall Space Flight Center (MSFC) flat floor.

Massless rotating fermions inside a cylinder

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ambruş, Victor E., E-mail: victor.ambrus@gmail.com; Winstanley, Elizabeth

2015-12-07

We study rotating thermal states of a massless quantum fermion field inside a cylinder in Minkowski space-time. Two possible boundary conditions for the fermion field on the cylinder are considered: the spectral and MIT bag boundary conditions. If the radius of the cylinder is sufficiently small, rotating thermal expectation values are finite everywhere inside the cylinder. We also study the Casimir divergences on the boundary. The rotating thermal expectation values and the Casimir divergences have different properties depending on the boundary conditions applied at the cylinder. This is due to the local nature of the MIT bag boundary condition, whilemore » the spectral boundary condition is nonlocal.« less

ORION-II: A True Formation Flying Mission in LEO

NASA Technical Reports Server (NTRS)

How, Jonathan P.

2004-01-01

The final report for the Orion-II project is taken from Chapter 5 of "CDGPS-Based Relative Navigation for Multiple Spacecraft," a thesis by Megan Mitchell submitted to the MIT Department of Aeronautics and Astronautics, June 2004. This chapter begins with a comparison of the simulation architecture for the original and current simulation setups. Next, the changes made to the individual components of the navigation system are described. Finally, tests performed with a Spirent Simulator at NASA Goddard Space Flight Center (GSFC) are discussed. In addition to the development of the testbed components described, a new clean room facility was developed in the Orion Laboratory at MIT.

Single-Stage, 3.4:1-Pressure-Ratio Aspirated Fan Developed and Demonstrated

NASA Technical Reports Server (NTRS)

Braunscheidel, Edward P.

2004-01-01

Researchers are constantly pursuing technologies that will increase the performance of gas turbine engines. The aspirated compressor concept discussed here would allow the compression system to perform its task with about one-half of the compressor blades. To accomplish this, the researchers applied boundary layer control to the blades, casing, and hub. This method of boundary layer control consisted of removing small amounts of air from the main flow path at critical areas of the compressor. This bleed air could be used by other systems such as engine cooling or could be re-injected into lower pressure areas that require air for enhanced performance. This effort was initiated by the Massachusetts Institute of Technology (MIT) in response to a solicitation from the Defense Advanced Research Projects Agency (DARPA) who sought to advance research in flow control technology. The NASA Glenn Research Center partnered with MIT (principal investigator), Honeywell Aircraft Engines (cycle analysis, structural analysis, and mechanical design), and Pratt & Whitney (cycle analysis and aero-analysis) to conceptualize, design, analyze, build, and test the aspirated fan stage. The aero-design and aero-analysis of this fan stage were jointly executed by MIT and Glenn to minimize the amount of bleed flow needed and to maintain the highest efficiency possible (ref. 1). Mechanical design issues were complicated by the need to have a shrouded rotor with hollow blades, with rotor stress levels beyond the capabilities of titanium. The high stress issues were addressed by designing a shroud that was filament wound with a carbon fiber/epoxy matrix, resulting in an assembly that was strong enough to handle the high stresses. Both the rotor (preceding photographs) and stator (following photograph) were fabricated in two halves and then bolted together at the hub and tip, permitting the bleed passages to be machined into each half before assembly.

[Microfabricated X-ray Optics Technology Development for the Constellation X-Mission

NASA Technical Reports Server (NTRS)

Schattenburg, Mark L.

2005-01-01

MIT has previously developed advanced methods for the application of silicon microstructures (so-called microcombs) in the precision assembly of foil x-ray optics in support of the Constellation-X Spectroscopy X-ray Telescope (SXT) technology development at the NASA Goddard Space Flight Center (GSFC). During the first year of the above Cooperative Agreement, MIT has developed a new, mature, potentially high- yield process for the manufacturing of microcombs that can be applied to a range of substrates independent of thickness. MIT also developed techniques to extract microcomb accuracy from an assembly truss metrology test stand and to extend the dynamic range of its Shack-Hartmann foil metrology tool. The placement repeatability of foil optics with microcombs in the assembly truss has been improved by a factor of two to approximately 0.15 micron. This was achieved by electric contact determination in favor of determining contact through force measurements. Development work on a stress-free thin foil holder was also supported by this agreement and successfully continued under a different grant.

Transiting Exoplanet Survey Satellite (TESS) Briefing

NASA Image and Video Library

2018-03-28

George Ricker, TESS principal investigator, MIT Kavli Institute for Astrophysics and Space Research, discusses the upcoming launch of NASA’s next planet hunter, the Transiting Exoplanet Survey Satellite (TESS), Wednesday, March 28, 2018 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

Transforming an Introductory Programming Course: From Lectures to Active Learning via Wireless Laptops

ERIC Educational Resources Information Center

Barak, Miri; Harward, Judson; Kocur, George; Lerman, Steven

2007-01-01

Within the framework of MIT's course 1.00: Introduction to Computers and Engineering Problem Solving, this paper describes an innovative project entitled: "Studio 1.00" that integrates lectures with in-class demonstrations, active learning sessions, and on-task feedback, through the use of wireless laptop computers. This paper also describes a…

Approximate Fluid-Structure Interaction Theories for Acoustic Echo Signal Predictions.

DTIC Science & Technology

1981-10-19

mations for Structure-Fluid Interaction Analysis," PA,,e𔃻n:s the Second International Symposium on Tnnovative Nijm,r;-a’ An.ti si in Applied ... Engineering Science, Montreal, Canada, June !,150, pi. 79-88. 8. Junger, M.C. and Feit, D., Sound. Structures and tht ir Tu,>i the MIT Press, Cambridge, MA

Wanted: Well-Rounded Students Who Can Think

ERIC Educational Resources Information Center

Clough, G. Wayne

2008-01-01

The author states that the U.S. is at risk of falling behind in the global economic competition because too few of the young people are choosing to study fields like engineering and science. A 2005-06 Lemelson-MIT Invention Index survey found that while American teenagers are comfortable with rapid technological change and optimistic about the…

First Observations of a Stellar Occultation by KBO (50000) Quaoar from MIT's George R. Wallace, Jr., Astrophysical Observatory

NASA Astrophysics Data System (ADS)

Sallum, Stephanie; Brothers, T.; Elliot, J. L.; Person, M. J.; Bosh, A. S.; Zangari, A.; Zuluaga, C.; Levine, S.; Bright, L.; Sheppard, S.; Tilleman, T.

2011-05-01

Here we report the first recorded observations of a stellar occultation by Kuiper Belt Object (KBO) (50000) Quaoar. We detected a single-chord stellar occultation by Quaoar of a magnitude 16.2 star designated 26029635 UCAC2 (2MASS ID 1275509401), which occurred on 11 February 2011 UT. The prediction of the occultation was made using long baseline astrometric observations of Quaoar from several sites as part of the MIT Planetary Astronomy Laboratory's continuing effort to improve KBO positions for occultation prediction. The successful observations were made with a Celestron C14 0.36 m telescope and an SBIG STL-1001E CCD camera on a Paramount ME robotic mount. These observations show that a relatively accessible level of astronomical equipment, of the class often used by amateur astronomers, can be used to record KBO occultations. The data were taken at MIT's George R. Wallace, Jr., Astrophysical Observatory in Westford, MA. A light curve was generated from the data using aperture photometry on the individual images and is presented here. This light curve is being analyzed by Person et al. (this meeting) to provide constraints on Quaoar's size. We also discuss various observing strategies that could be used in the future to optimize the data from this type of event. This work was supported in part by grant NNX10AB27G to MIT from NASA's Planetary Astronomy Division. Student participation was supported in part by NSF's REU program, MIT's Undergraduate Research Opportunities Program, NASA's Massachusetts Space Grant, and the George R. Wallace, Jr., Astrophysical Observatory.

The presence of glutamate residues on the PAS sequence of the stimuli-sensitive nano-ferritin improves in vivo biodistribution and mitoxantrone encapsulation homogeneity.

PubMed

Falvo, Elisabetta; Malagrinò, Francesca; Arcovito, Alessandro; Fazi, Francesco; Colotti, Gianni; Tremante, Elisa; Di Micco, Patrizio; Braca, Aldo; Opri, Roberta; Giuffrè, Alessandro; Fracasso, Giulio; Ceci, Pierpaolo

2018-04-10

A genetically engineered human ferritin heavy chain (HFt)-based construct has been recently shown by our group to efficiently entrap and deliver doxorubicin to cancer cells. This construct, named HFt-MP-PAS, contained a tumor-selective sequence (MP) responsive to proteolytic cleavage by tumor proteases (MMPs), located between each HFt subunit and an outer shielding polypeptide sequence rich in proline (P), serine (S) and alanine (A) residues (PAS). HFt-MP-PAS displayed excellent therapeutic efficacy in xenogenic pancreatic and head and neck cancer models in vivo, leading to a significant increase in overall animal survivals. Here we report a new construct obtained by the genetic insertion of two glutamate residues in the PAS sequence of HFt-MP-PAS. Such new construct, named HFt-MP-PASE, is characterized by improved performances as drug biodistribution in a xenogenic pancreatic cancer model in vivo. Moreover, HFt-MP-PASE efficiently encapsulates the anti-cancer drug mitoxantrone (MIT), and the resulting MIT-loaded nanoparticles proved to be more soluble and monodispersed than the HFt-MP-PAS counterparts. Importantly, in vitro MIT-loaded HFt-MP-PASE kills several cancer cell lines of different origin (colon, breast, sarcoma and pancreas) at least as efficiently as the free drug. Finally, our MIT loaded protein nanocages allowed in vivo an impressive incrementing of the drug accumulation in the tumor with respect to the free drug. Copyright © 2018 Elsevier B.V. All rights reserved.

An integrated dexterous robotic testbed for space applications

NASA Technical Reports Server (NTRS)

Li, Larry C.; Nguyen, Hai; Sauer, Edward

1992-01-01

An integrated dexterous robotic system was developed as a testbed to evaluate various robotics technologies for advanced space applications. The system configuration consisted of a Utah/MIT Dexterous Hand, a PUMA 562 arm, a stereo vision system, and a multiprocessing computer control system. In addition to these major subsystems, a proximity sensing system was integrated with the Utah/MIT Hand to provide capability for non-contact sensing of a nearby object. A high-speed fiber-optic link was used to transmit digitized proximity sensor signals back to the multiprocessing control system. The hardware system was designed to satisfy the requirements for both teleoperated and autonomous operations. The software system was designed to exploit parallel processing capability, pursue functional modularity, incorporate artificial intelligence for robot control, allow high-level symbolic robot commands, maximize reusable code, minimize compilation requirements, and provide an interactive application development and debugging environment for the end users. An overview is presented of the system hardware and software configurations, and implementation is discussed of subsystem functions.

MIT research in telerobotics

NASA Technical Reports Server (NTRS)

Sheridan, T. B.

1987-01-01

Ongoing MIT research in telerobotics (vehicles capable of some autonomous sensing and manipulating, having some remote supervisory control by people) and teleoperation (vehicles for sensing and manipulating which are fully controlled remotely by people) is discussed. The current efforts mix human and artificial intelligence/control. The idea of adjustable impedance at either end of pure master-slave teleoperation, and simultaneous coordinated control of teleoperator/telerobotic systems which have more than six degrees of freedom (e.g., a combined vehicle and arm, each with five or six DOF) are discussed. A new cable-controlled parallel link arm which offers many advantages over conventional arms for space is briefly described. Predictor displays to compensate for time delay in teleoperator loops, the use of state estimation to help human control decisions in space, and ongoing research in supervisory command language are covered. Finally, efforts to build a human flyable real-time dynamic computer-graphic telerobot simulator are described. These projects represent most, but not all, of the telerobotics research in our laboratory, supported by JPL, NASA Ames and NOAA.

System Architectural Considerations on Reliable Guidance, Navigation, and Control (GN and C) for Constellation Program (CxP) Spacecraft

NASA Technical Reports Server (NTRS)

Dennehy, Cornelius J.

2010-01-01

This final report summarizes the results of a comparative assessment of the fault tolerance and reliability of different Guidance, Navigation and Control (GN&C) architectural approaches. This study was proactively performed by a combined Massachusetts Institute of Technology (MIT) and Draper Laboratory team as a GN&C "Discipline-Advancing" activity sponsored by the NASA Engineering and Safety Center (NESC). This systematic comparative assessment of GN&C system architectural approaches was undertaken as a fundamental step towards understanding the opportunities for, and limitations of, architecting highly reliable and fault tolerant GN&C systems composed of common avionic components. The primary goal of this study was to obtain architectural 'rules of thumb' that could positively influence future designs in the direction of an optimized (i.e., most reliable and cost-efficient) GN&C system. A secondary goal was to demonstrate the application and the utility of a systematic modeling approach that maps the entire possible architecture solution space.

Another Philadelphia Story: Mobilizing Resistance and Widening the Educational Imagination in the Midst of Corporate Assault on the Public Sphere

ERIC Educational Resources Information Center

Fine, Michelle

2013-01-01

Information about the MIT Media Lab PLATFORM, a Summit of Innovators, is presented. This Summit was comprised of engineers, computer scientists, coders, activists, designers, and technology wizards, a gathering of people of color who have been remarkably successful, provocative, and creative against the odds. The event enabled the author and other…

Searching for Twitter Posts by Location

DTIC Science & Technology

2015-09-27

Searching for Twitter Posts by Location Ariana Minot Harvard University School of Engineering and Applied Sciences Cambridge, MA, USA minot...fas.harvard.edu Andrew Heier, Davis King, Olga Simek, Nick Stanisha MIT Lincoln Laboratory Lexington, MA, USA ABSTRACT The microblogging service Twitter is an...increasingly popular platform for sharing information worldwide. This motivates the potential to mine information from Twitter , which can serve as a

Searching for Twitter Posts by Location

DTIC Science & Technology

2015-09-27

Searching for Twitter Posts by Location Ariana Minot Harvard University School of Engineering and Applied Sciences Cambridge, MA, USA minot...fas.harvard.edu Andrew Heier, Davis King, Olga Simek MIT Lincoln Laboratory Lexington, MA, USA ABSTRACT The microblogging service Twitter is an increasingly...popular platform for sharing information worldwide. This motivates the potential to mine information from Twitter , which can serve as a valuable

WOMEN AND THE SCIENTIFIC PROFESSIONS, THE M.I.T. SYMPOSIUM ON AMERICAN WOMEN IN SCIENCE AND ENGINEERING.

ERIC Educational Resources Information Center

MATTFELD, JACQUELYN A.; VAN AKEN, CAROL G.

REPORTED IS A SYMPOSIUM ON WOMEN AND THE SCIENTIFIC PROFESSIONS. SPONSORED BY THE ASSOCIATION OF WOMEN STUDENTS OF THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY, IT WAS ATTENDED BY 260 STUDENT DELEGATES FROM 140 COLLEGES, AS WELL AS BY 600 GUESTS INCLUDING COLLEGE DEANS, HIGH SCHOOL GUIDANCE COUNSELORS, WOMEN PROFESSIONALLY EMPLOYED IN SCIENCE,…

Physical Controls on Copepod Aggregations in the Gulf of Maine

DTIC Science & Technology

2013-06-01

endangered North Atlantic right whales . Certain ocean processes may generate dense copepod aggrega- tions, while others may destroy them; this thesis...for tropical ocean - global atmosphere coupled- ocean atmosphere response experiment. Journal of Geophysical Research, 101, 3747–3764. Fong, D., W...Oceanography/ Applied Ocean Science and Engineering Massachusetts Institute of Technology Woods Hole Oceanographic Institution MIT/WHOI 2013-18

Diversity and Phylogenetic Structure of Two Complex Marine Microbial Communities

DTIC Science & Technology

2004-09-01

Science 190 and Engineering DOCTORAL DISSERTATION Diversity and Phylogenetic Structure of Two Complex Marine Microbial Communities by Vanja Klepac-Ceraj...Two Complex Marine Microbial Communities by Vanja Klepac-Ceraj Massachusetts Institute of Technology Cambridge, Massachusetts 02139 and Woods Hole...Phylogenetic Structure of Two Complex Marine Microbial Communities. Ph.D. Thesis. MIT/WHOI, 2004-11. Approved for publication; distribution unlimited

Challenge-based instruction in biomedical engineering: a scalable method to increase the efficiency and effectiveness of teaching and learning in biomedical engineering.

PubMed

Harris, Thomas R; Brophy, Sean P

2005-09-01

Vanderbilt University, Northwestern University, the University of Texas and the Harvard/MIT Health Sciences Technology Program have collaborated since 1999 to develop means to improve bioengineering education. This effort, funded by the National Science Foundation as the VaNTH Engineering Research Center in Bioengineering Educational Technologies, has sought a synthesis of learning science, learning technology, assessment and the domains of bioengineering in order to improve learning by bioengineering students. Research has shown that bioengineering educational materials may be designed to emphasize challenges that engage the student and, when coupled with a learning cycle and appropriate technologies, can lead to improvements in instruction.

DIY Media Creation

ERIC Educational Resources Information Center

Fields, Deborah A.; Magnifico, Alecia Marie; Lammers, Jayne C.; Curwood, Jen Scott

2014-01-01

Research suggests that young adults are motivated in school contexts when they believe in their own self-efficacy, have intrinsic motivation, set goals, experience agency, and demonstrate interest. To highlight how online spaces foster motivation, we focus specifically on two project-based DIY sites, Figment.com and Scratch.mit.edu. From reading…

Aerodynamics Simulations for the D8 ``Double Bubble'' Aircraft Using the LAVA Unstructured Solver

NASA Astrophysics Data System (ADS)

Ballinger, Sean

2013-11-01

The D8 ``double bubble'' is a proposed design for quieter and more efficient domestic passenger aircraft of the Boeing 737 class. It features boundary layer-ingesting engines located under a non-load-bearing π-tail and a lightweight low-sweep wing for flight around Mach 0.7. The D8's wide lifting body is expected to supply 15% of its total lift, while a Boeing 737's fuselage contributes only 8%. The tapering rear of the fuselage is also predicted to experience a negative moment resulting in positive pitch, produce a thicker boundary layer for ingestion by distortion-tolerant engines, and act as a noise shield. To investigate these predictions, unstructured grids generated over a fine surface triangulation using Star-CCM+ are used to model the unpowered D8 with flow conditions mimicking those in the MIT Wright brothers wind tunnel at angles of attack from - 2 to 14 degrees. LAVA, the recently developed Launch Ascent and Vehicle Aerodynamics solver, is used to carry out simulations on an unstructured grid. The results are compared to wind tunnel data, and to data from structured grid simulations using the LAVA, Overflow, and Cart3D solvers. Applied Modeling and Simulation Branch, NASA Advanced Supercomputing Division, funded by New York Space Grant.

Near Earth Architectural Options for a Future Deep Space Optical Communications Network

NASA Technical Reports Server (NTRS)

Edwards, B. L.; Liebrecht, P. E.; Fitzgerald, R. J.

2004-01-01

In the near future the National Aeronautics and Space Administration anticipates a significant increase in demand for long-haul communications services from deep space to Earth. Distances will range from 0.1 to 40 AU, with data rate requirements in the 1's to 1000's of Mbits/second. The near term demand is driven by NASA's Space Science Enterprise which wishes to deploy more capable instruments onboard spacecraft and increase the number of deep space missions. The long term demand is driven by missions with extreme communications challenges such as very high data rates from the outer planets, supporting sub-surface exploration, or supporting NASA's Human Exploration and Development of Space Enterprise beyond Earth orbit. Laser communications is a revolutionary communications technology that will dramatically increase NASA's ability to transmit information across the solar system. Lasercom sends information using beams of light and optical elements, such as telescopes and optical amplifiers, rather than RF signals, amplifiers, and antennas. This paper provides an overview of different network options at Earth to meet NASA's deep space lasercom requirements. It is based mainly on work done for the Mars Laser Communications Demonstration Project, a joint project between NASA's Goddard Space Flight Center (GSFC), the Jet Propulsion Laboratory, California Institute of Technology (JPL), and the Massachusetts Institute of Technology Lincoln Laboratory (MIT/LL). It reports preliminary conclusions from the Mars Lasercom Study conducted at MIT/LL and on additional work done for the Tracking and Data Relay Satellite System Continuation Study at GSFC. A lasercom flight terminal will be flown on the Mars Telesat Orbiter (MTO) to be launched by NASA in 2009, and will be the first high rate deep space demonstration of this revolutionary technology.

Wind and IMP 8 Solar Wind, Magnetosheath and Shock Data

NASA Technical Reports Server (NTRS)

2004-01-01

The purpose of this project was to provide the community access to magnetosheath data near Earth. We provided 27 years of IMP 8 magnetosheath proton velocities, densities, and temperatures with our best (usually 1-min.) time resolution. IMP 8 crosses the magnetosheath twice each 125 day orbit, and we provided magnetosheath data for the roughly 27 years of data for which magnetometer data are also available (which are needed to reliably pick boundaries). We provided this 27 years of IMP 8 magnetosheath data to the NSSDC; this data is now integrated with the IMP 8 solar wind data with flags indicating whether each data point is in the solar wind, magnetosheath, or at the boundary between the two regions. The plasma speed, density, and temperature are provided for each magnetosheath point. These data are also available on the MIT web site ftp://space .mit.edu/pub/plasma/imp/www/imp.html. We provide ASCII time-ordered rows of data giving the observation time, the spacecraft position in GSE, the velocity is GSE, the density and temperature for protons. We also have analyzed and archived on our web site the Wind magnetosheath plasma parameters. These consist of ascii files of the proton and alpha densities, speeds, and thermal speeds. These data are available at ftp://space.mit.edu/pub/plasma/wind/sheath These are the two products promised in the work statement and they have been completed in full.

Transiting Exoplanet Survey Satellite (TESS) Briefing

NASA Image and Video Library

2018-03-28

George Ricker, TESS principal investigator, MIT Kavli Institute for Astrophysics and Space Research, is seen during a media briefing holding one of the wafers from which the Transiting Exoplanet Survey Satellite (TESS) camera charge coupled device (CCD) were fabricated, Wednesday, March 28, 2018 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

Moments in the Life of a Scientist

NASA Astrophysics Data System (ADS)

Rossi, Bruno

2008-07-01

List of plates; Foreword; Preface; Prehistory; 1. Arcetri (1928-32); 2. Padua, Copenhagen, Manchester; 3. Physics of elementary particles in the Age of Innocence (1939-46); 4. Los Alamos (1943-46); 5. Cosmic rays at MIT (1946- ); 6. Physics in space; Postscript; As for me … Nora Rossi; Index.

Overview of the MARS Laser Communications Demonstration Project

NASA Technical Reports Server (NTRS)

Edward, Bernard L.; Townes, Stephen A.; Bondurant, Roy S.; Scozzafava, Joseph J.; Boroson, Don M.; Parvin, Ben A.; Biswas, Abhijit; Pillsbury, Alan D.; Khatri, Farzana I.; Burnside, Jamie W.

2003-01-01

This paper provides an overview of the Mars Laser Communications Demonstration Project, a joint project between NASA s Goddard Space Flight Center (GSFC), the Jet Propulsion Laboratory, California Institute of Technology (JPL), and the Massachusetts Institute of Technology Lincoln Laboratory (MIT/LL). It reviews the strawman designs for the flight and ground segments, the critical technologies required, and the concept of operations. It reports preliminary conclusions from the Mars Lasercom Study conducted at MIT/LL and on additional work done at JPL and GSFC. The lasercom flight terminal will be flown on the Mars Telecom Orbiter (MTO) to be launched by NASA in 2009, and will demonstrate a technology which has the potential of vastly improving NASA s ability to communicate throughout the solar system.

Influences On The Oceanic Biogeochemical Cycling Of The Hybrid-Type Metals: Cobalt, Iron, And Manganese

DTIC Science & Technology

2012-02-01

have been possible. We also thank Scot Birdwhistell in the Woods Hole Oceanographic Institution (WHOI) inductively coupled plasma mass spectrometry...Cobalt, Iron, and Manganese MIT/WHOI Joint Program in Oceanography/ Applied Ocean Science and Engineering Massachusetts Institute of Technology Woods Hole...by Abigail Emery Noble Massachusetts Institute of Technology Cambridge, Massachusetts 02139 and Woods Hole Oceanographic Institution Woods Hole

Security Studies Program

DTIC Science & Technology

2004-01-01

Department. The SSP faculty, however, includes natural scientists and engineers as well as social scientists. Distinguishing the program is its ability to...Humanities, Arts, and Social Sciences at MIT and seeks to encourage the analysis of issues of continuing public concern. Key components of the Center in...by a Europe worried about meeting promised social welfare benefits for a rapidly aging population. Americans cannot avoid the war with mili- tant

Managing Productivity and Quality in the 1990s. Some Observations on TIMS (The Institute for Management Sciences) XXIX, 23-26 July 1989, Osaka, Japan

DTIC Science & Technology

1989-10-01

often attempted. This profound knowledge must be possessed by management; hence Dr. Deming’s slogan: "Quality is Made in the Boardroom ." Dr. Deming...Out of the Crisis, MIT Center for Advanced Engineering Study, Cambridge, MA, 1982. 5. Lawrence M. Miller, Barbarians to Bureaucrats, Corporate Life

Detection and Imaging of Moving Targets with LiMIT SAR Data

DTIC Science & Technology

2017-03-03

include space time adaptive processing (STAP) or displaced phase center antenna (DPCA) [4]–[7]. Page et al. combined constant acceleration target...motion focusing with space-time adaptive processing (STAP), and included the refocusing parameters in the STAP steering vector. Due to inhomogenous...wavelength λ and slow time t, of a moving target after matched filter and passband equalization processing can be expressed as: P (t) = exp ( −j 4π λ ||~rp

Satellite Relative Motion Control for MIT’s SPHERES Program

DTIC Science & Technology

2012-03-01

rates of the SPHERES position and velocity are modeled. Section 2.5.2 illustrates how to deter- mine the quaternions and the angular rates to...velocity components are determined following the process described in Section 2.4.5. Once the feedback gains are deter- mined the switch line of the bang...Using Lasers in Space: Laser Orbital Debris Removal and Asteroid Deflection,” 2000. 17. Rogers, M. E., “Lasers in Space: Technological Options for

Integrated optomechanical analysis and testing software development at MIT Lincoln Laboratory

NASA Astrophysics Data System (ADS)

Stoeckel, Gerhard P.; Doyle, Keith B.

2013-09-01

Advanced analytical software capabilities are being developed to advance the design of prototypical hardware in the Engineering Division at MIT Lincoln Laboratory. The current effort is focused on the integration of analysis tools tailored to the work flow, organizational structure, and current technology demands. These tools are being designed to provide superior insight into the interdisciplinary behavior of optical systems and enable rapid assessment and execution of design trades to optimize the design of optomechanical systems. The custom software architecture is designed to exploit and enhance the functionality of existing industry standard commercial software, provide a framework for centralizing internally developed tools, and deliver greater efficiency, productivity, and accuracy through standardization, automation, and integration. Specific efforts have included the development of a feature-rich software package for Structural-Thermal-Optical Performance (STOP) modeling, advanced Line Of Sight (LOS) jitter simulations, and improved integration of dynamic testing and structural modeling.

Natural Oil Production from Microorganisms: Bioprocess and Microbe Engineering for Total Carbon Utilization in Biofuel Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-07-15

Electrofuels Project: MIT is using carbon dioxide (CO2) and hydrogen generated from electricity to produce natural oils that can be upgraded to hydrocarbon fuels. MIT has designed a 2-stage biofuel production system. In the first stage, hydrogen and CO2 are fed to a microorganism capable of converting these feedstocks to a 2-carbon compound called acetate. In the second stage, acetate is delivered to a different microorganism that can use the acetate to grow and produce oil. The oil can be removed from the reactor tank and chemically converted to various hydrocarbons. The electricity for the process could be supplied frommore » novel means currently in development, or more proven methods such as the combustion of municipal waste, which would also generate the required CO2 and enhance the overall efficiency of MIT’s biofuel-production system.« less

Turbine Chemistry Modeling

NASA Technical Reports Server (NTRS)

Liu, Nan-Suey; Wey, Thomas

2001-01-01

Many of the engine exhaust species resulting in significant environmental impact exist in trace amounts. Recent research, e.g., conducted at MIT-AM, has pointed to the intra-engine environment as a possible site for important trace chemistry activity. In addition, the key processes affecting the trace species activity occurring downstream in the air passages of the turbine and exhaust nozzle are not well understood. Most recently, an effort has been initiated at NASA Glenn Research Center under the UEET Program to evaluate and further develop CFD-based technology for modeling and simulation of intra-engine trace chemical changes relevant to atmospheric effects of pollutant emissions from aircraft engines. This presentation will describe the current effort conducted at Glenn; some preliminary results relevant to the trace species chemistry in a turbine passage will also be presented to indicate the progress to date.

Transiting Exoplanet Survey Satellite (TESS) Briefing

NASA Image and Video Library

2018-03-28

George Ricker, TESS principal investigator, MIT Kavli Institute for Astrophysics and Space Research, is seen during a media briefing where he and other experts discuss the upcoming launch of NASA’s next planet hunter, the Transiting Exoplanet Survey Satellite (TESS), Wednesday, March 28, 2018 at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

A Head Start to a Healthy Heart

NASA Technical Reports Server (NTRS)

2002-01-01

Cambridge Heart, Inc., has licensed the only U.S. Food and Drug Administration-cleared tool to identify those at risk for sudden cardiac death (SCD). The Microvolt T-Wave Alternans Test(TM) was invented by Dr. Richard J. Cohen, a professor at the Harvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, with developmental support and funding from NASA's Johnson Space Center and the National Space Biomedical Research Institute (NSBRI) in Houston, Texas. In 1993, MIT licensed the technology to Cambridge Heart, Inc., a start-up company that Dr. Cohen helped to establish. Cambridge Heart's non-invasive technology measures T-wave alternans, a change from one heartbeat to the next that is too minute to be detected by a standard electrocardiogram. Cardiac patients with such a change in heartbeat regulation are faced with a much greater risk of ventricular arrhythmia and SCD than those without it. The company's ability to measure electrical alternans on a microvolt level has been clinically proven to be just as accurate as - and in some studies, more accurate than - more costly and somewhat risky, invasive procedures, such as electrophysiological testing.

NASA Education and Public Outreach Initiatives at the MIT Center for Space Research

NASA Astrophysics Data System (ADS)

Porro, I. L.

2003-12-01

Since its inception in 1999, the EPO office of the MIT Center for Space Research (CSR) has fostered direct participation of local scientists in educational initiatives such as teachers workshops and public tours of the Chandra Operations and Control Center. The role played by the CSR EPO office has grown significantly, thanks to the award of a number of EPO grants associated with the Chandra and HETE missions. In the past year about one-third of the CSR research staff was involved in the office's EPO initiatives: more than 500 K-12 students, about half from underrepresented groups, were included in formal education programs and informal education events attracted an estimated 900 people. Today the mission of the CSR EPO office is focused in two areas: professional development for K-12 science teachers, and educational programs in out-of-school time. To be associated with major NASA research missions is beneficial to our mission in several respects, but provides also specific challenges. We present here some of the strategies and intiatives that we have undertaken to overcome those challenges.

Near-Inertial and Thermal Upper Ocean Response to Atmospheric Forcing in the North Atlantic Ocean

DTIC Science & Technology

2010-06-01

meridional transport of heat (Hoskins and Valdes, 1990). Formation of North Atlantic Subtropical Mode Water is thought to take place during the...North Atlantic Ocean MIT/WHOI Joint Program in Oceanography/ Applied Ocean Science and Engineering Massachusetts Institute of Technology Woods Hole...Oceanographic Institution MITIWHOI 2010-16 Near-inertial and Thermal Upper Ocean Response to Atmospheric Forcing in the North Atlantic Ocean by

A Spatial Display for Ground-Penetrating Radar Change Detection

DTIC Science & Technology

2013-09-01

rights reserved. Author ............................ Department of Electrical Engineering and Computer Science September 1, 2013 Certified by...a new member of the Lincoln community. Thank you, Rebecca, for being you and being here with me at MIT. I would like to thank my parents for their...alteration in the height of dirt under it. This capability will raise the chance of detecting a place where someone buried an object by detecting the

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mac Donald, Philip Elsworth; Buongiorno, Jacopo; Davis, Cliff Bybee

The purpose of this collaborative Idaho National Engineering and Environmental Laboratory (INEEL) and Massachusetts Institute of Technology (MIT) Laboratory Directed Research and Development (LDRD) project is to investigate the suitability of lead or lead-bismuth cooled fast reactors for producing low-cost electricity as well as for actinide burning. The goal is to identify and analyze the key technical issues in core neutronics, materials, thermal-hydraulics, fuels, and economics associated with the development of this reactor concept. Work has been accomplished in four major areas of research: core neutronic design, plant engineering, material compatibility studies, and coolant activation. The publications derived from workmore » on this project (since project inception) are listed in Appendix A.« less

Comparison of incoherent scatter radar observations of SIMPLEX electron density depletion with SAMI2 and SAMI3 model results

NASA Astrophysics Data System (ADS)

Bhatt, A.; Huba, J. D.; Bernhardt, P. A.; Erickson, P. J.

2010-12-01

The Space Shuttle's Orbital Maneuvering System (OMS) engines have been used for active ionospheric modification experiments employing ground based ionospheric radars as diagnostic tools. These experiments initiated by the Naval Research Laboratory in 1995 have been scheduled as the Shuttle Ionospheric Modification with Pulsed Localized Exhaust or SIMPLEX through the US Dept. of Defense's Space Test Program. During 2009, two SIMPLEX experiments with the shuttles STS-119 and STS-128 were viewed by the Millstone Hill 440 MHz radar in Westford, MA operated by the MIT Haystack Observatory. The objectives of these experiments were to observe local ion-acoustic turbulence and the ionospheric density irregularities created by the exhaust injection across the magnetic field that present a Bragg scattering target for the radar. The exhaust also creates a depletion in the background electron density at F-region altitudes that persists for a relatively long time and is readily detected by an incoherent scatter radar. The OMS engine burns release 10 kg/s of H2O, CO2, H2, and N2 molecules that charge exchange with ambient O+ ions at the F region heights, producing molecular ions and the electron density depletion due to the recombination with the ambient electrons. 2009 was a year of deep solar minimum that saw the background electron density values 19% lower than were expected during a solar minimum. (Emmert et al., GRL, 2010). We believe that the long recovery time from density depletion in SIMPLEX experiments of 2009 may have a root in the unique nature of the deep solar minimum. The density whole production and recovery will be modeled using NRL SAMI2 and SAMI3 model and the results will be discussed along with the observations using the incoherent scatter radar.

The NASA-JPL advanced propulsion program

NASA Technical Reports Server (NTRS)

Frisbee, Robert H.

1994-01-01

The NASA Advanced Propulsion Concepts (APC) program at the Jet Propulsion Laboratory (JPL) consists of two main areas: The first involves cooperative modeling and research activities between JPL and various universities and industry; the second involves research at universities and industry that is directly supported by JPL. The cooperative research program consists of mission studies, research and development of ion engine technology using C-60 (Buckminsterfullerene) propellant, and research and development of lithium-propellant Lorentz-force accelerator (LFA) engine technology. The university/industry- supported research includes research (modeling and proof-of-concept experiments) in advanced, long-life electric propulsion, and in fusion propulsion. These propulsion concepts were selected primarily to cover a range of applications from near-term to far-term missions. For example, the long-lived pulsed-xenon thruster research that JPL is supporting at Princeton University addresses the near-term need for efficient, long-life attitude control and station-keeping propulsion for Earth-orbiting spacecraft. The C-60-propellant ion engine has the potential for good efficiency in a relatively low specific impulse (Isp) range (10,000 - 30,000 m/s) that is optimum for relatively fast (less than 100 day) cis-lunar (LEO/GEO/Lunar) missions employing near-term, high-specific mass electric propulsion vehicles. Research and modeling on the C-60-ion engine are currently being performed by JPL (engine demonstration), Caltech (C-60 properties), MIT (plume modeling), and USC (diagnostics). The Li-propellant LFA engine also has good efficiency in the modest Isp range (40,000 - 50,000 m/s) that is optimum for near-to-mid-term megawatt-class solar- and nuclear-electric propulsion vehicles used for Mars missions transporting cargo (in support of a piloted mission). Research and modeling on the Li-LFA engine are currently being performed by JPL (cathode development), Moscow Aviation Institute (engine testing), Thermacore (electrode development), as well as at MIT (plume modeling), and USC (diagnostics). Also, the mission performance of a nuclear-electric propulsion (NEP) Li-LFA Mars cargo vehicle is being modeled by JPL (mission analysis; thruster and power processor modeling) and the Rocketdyne Energy Technology and Engineering Center (ETEC) (power system modeling). Finally, the fusion propulsion research activities that JPL is supporting at Pennsylvania State University (PSU) and at Lawrenceville Plasma Physics (LPP) are aimed at far-term fast (less than 100 day round trip) piloted Mars missions and, in the very far term, interstellar missions.

Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT.

PubMed

Song, Ning; Zhao, Ming; Wang, Yuji; Hu, Xi; Wu, Jianhui; Jiang, Xueyun; Li, Shan; Cui, Chunying; Peng, Shiqi

2016-01-01

In spite of the usual combination form of methotrexate (MTX)/mitoxantrone (MIT) and various complex combination regimens of MTX/MIT with other anticancer drugs, the survival period, cure rate, and systemic toxicity still need to be improved. For this purpose, a nanostructured amino group-modified mesoporous silica nanoparticles (MSNN)-MTX/MIT was designed. In the preparation, the surface of mesoporous silica nanoparticles (MSNs) was modified with amino groups to form MSNN. The covalent modification of the amino groups on the surface of MSNN with MTX resulted in MSNN-MTX. The loading of MIT into the surface pores of MSNN-MTX produced nanostructured MSNN-MTX/MIT. Compared with the usual combination form (MTX/MIT), nanostructured MSNN-MTX/MIT increased the survival period greatly, heightened the cure rate to a great extent, and lowered the systemic toxicity of the treated S180 mice, significantly. These superior in vivo properties of nanostructured MSNN-MTX/MIT over the usual combination form (MTX/MIT) were correlated with the former selectively releasing MTX and MIT in tumor tissue and inside cancer cells in vitro. The chemical structure and the nanostructure of MSNN-MTX/MIT were characterized using infrared and differential scanning calorimeter spectra as well as transmission electron microscope images, respectively.

Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT

PubMed Central

Song, Ning; Zhao, Ming; Wang, Yuji; Hu, Xi; Wu, Jianhui; Jiang, Xueyun; Li, Shan; Cui, Chunying; Peng, Shiqi

2016-01-01

In spite of the usual combination form of methotrexate (MTX)/mitoxantrone (MIT) and various complex combination regimens of MTX/MIT with other anticancer drugs, the survival period, cure rate, and systemic toxicity still need to be improved. For this purpose, a nanostructured amino group-modified mesoporous silica nanoparticles (MSNN)−MTX/MIT was designed. In the preparation, the surface of mesoporous silica nanoparticles (MSNs) was modified with amino groups to form MSNN. The covalent modification of the amino groups on the surface of MSNN with MTX resulted in MSNN−MTX. The loading of MIT into the surface pores of MSNN−MTX produced nanostructured MSNN−MTX/MIT. Compared with the usual combination form (MTX/MIT), nanostructured MSNN−MTX/MIT increased the survival period greatly, heightened the cure rate to a great extent, and lowered the systemic toxicity of the treated S180 mice, significantly. These superior in vivo properties of nanostructured MSNN−MTX/MIT over the usual combination form (MTX/MIT) were correlated with the former selectively releasing MTX and MIT in tumor tissue and inside cancer cells in vitro. The chemical structure and the nanostructure of MSNN−MTX/MIT were characterized using infrared and differential scanning calorimeter spectra as well as transmission electron microscope images, respectively. PMID:27621591

Experimental Study of Current-Driven Turbulence During Magnetic Reconnection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Porkolab, Miklos; Egedal-Pedersen, Jan; Fox, William

CMPD Final Report Experimental Study of Current-Driven Turbulence During Magnetic Reconnection Miklos Porkolab, PI, Jan Egedal, co-PI, William Fox, graduate student. This is the final report for Grant DE-FC02-04ER54786, MIT Participation in the Center for Multiscale Plasma Dynamics, which was active from 8/1/2004 to 7/31/2010. This Grant supported the thesis work of one MIT graduate student, William Fox, The thesis research consisted of an experimental study of the fluctuations arising during magnetic reconnection in plasmas on the Versatile Toroidal Facility (VTF) at MIT Plasma Science and Fusion Center (PSFC). The thesis was submitted and accepted by the MIT physics Department,.more » Fox, Experimental Study of Current-Driven Turbulence During Magnetic Reconnection, Ph.D. Thesis, MIT (2009). In the VTF experiment reconnection and current-sheet formation is driven by quickly changing currents in a specially arranged set of internal conductors. Previous work on this device [Egedal, et al, PRL 98, 015003, (2007)] identified a spontaneous reconnection regime. In this work fluctuations were studied using impedance-matched, high-bandwidth Langmuir probes. Strong, broadband fluctuations, with frequencies extending from near the lower-hybrid frequency [fLH = (fcefci)1/2] to the electron cyclotron frequency fce were found to arise during the reconnection events. Based on frequency and wavelength measurements, lower-hybrid waves and Trivelpiece-Gould waves were identified. The lower-hybrid waves are easiest to drive with strong perpendicular drifts or gradients which arise due to the reconnection events; an appealing possibility is strong temperature gradients. The Trivelpiece-Gould modes can result from kinetic, bump-on-tail instability of a runaway electron population energized by the reconnection events. We also observed that the turbulence is often spiky, consisting of discrete positive-potential spikes, which were identified as electron phase-space holes, a class of nonlinear solitary wave known to evolve from a strong beam-on-tail instability. We established that fast electrons were produced by magnetic reconnection. Overall, these instabilities were found to be a consequence of reconnection, specifically the strong energization of electrons, leading to steep gradients in both coordinate- and velocity-space. Estimates (using quasi-linear theory) of the anomalous resistivity due to these modes did not appear large enough to substantially impact the reconnection process. Relevant publications: W. Fox, M. Porkolab, et al, Phys. Rev. Lett. 101, 255003 (2008). W. Fox, M. Porkolab, et al, Phys. Plasmas 17, 072303, (2010).« less

Athermal Photonic Devices and Circuits on a Silicon Platform

NASA Astrophysics Data System (ADS)

Raghunathan, Vivek

In recent years, silicon based optical interconnects has been pursued as an effective solution that can offer cost, energy, distance and bandwidth density improvements over copper. Monolithic integration of optics and electronics has been enabled by silicon photonic devices that can be fabricated using CMOS technology. However, high levels of device integration result in significant local and global temperature fluctuations that prove problematic for silicon based photonic devices. In particular, high temperature dependence of Si refractive index (thermo-optic (TO) coefficient) shifts the filter response of resonant devices that limit wavelength resolution in various applications. Active thermal compensation using heaters and thermo-electric coolers are the legacy solution for low density integration. However, the required electrical power, device foot print and number of input/output (I/O) lines limit the integration density. We present a passive approach to an athermal design that involves compensation of positive TO effects from a silicon core by negative TO effects of the polymer cladding. In addition, the design rule involves engineering the waveguide core geometry depending on the resonance wavelength under consideration to ensure desired amount of light in the polymer. We develop exact design requirements for a TO peak stability of 0 pm/K and present prototype performance of 0.5 pm/K. We explore the material design space through initiated chemical vapor deposition (iCVD) of 2 polymer cladding choices. We study the effect of cross-linking on the optical properties of a polymer and establish the superior performance of the co-polymer cladding compared to the homo-polymer. Integration of polymer clad devices in an electronic-photonic architecture requires the possibility of multi-layer stacking capability. We use a low temperature, high density plasma chemical vapor deposition of SiO2/SiN x to hermetically seal the athermal. Further, we employ visible light for post-fabrication trimming of athermal rings by sandwiching a thin photosensitive layer of As2S3 in between amorphous Si core and polymer top cladding. System design of an add-drop filter requires an optimum combination of channel counts performance and power handling capacity for maximum aggregate bandwidth. We establish the superior performance of athermal add-drop filter compared to a standard filter treating bandwidth as the figure-of-merit. (Copies available exclusively from MIT Libraries, libraries.mit.edu/docs - docs mit.edu)

Design of multifunctional magnetic iron oxide nanoparticles/mitoxantrone-loaded liposomes for both magnetic resonance imaging and targeted cancer therapy.

PubMed

He, Yingna; Zhang, Linhua; Zhu, Dunwan; Song, Cunxian

2014-01-01

Tumor-targeting multifunctional liposomes simultaneously loaded with magnetic iron oxide nanoparticles (MIONs) as a magnetic resonance imaging (MRI) contrast agent and anticancer drug, mitoxantrone (Mit), were developed for targeted cancer therapy and ultrasensitive MRI. The gonadorelin-functionalized MION/Mit-loaded liposome (Mit-GML) showed significantly increased uptake in luteinizing hormone-releasing hormone (LHRH) receptor overexpressing MCF-7 (Michigan Cancer Foundation-7) breast cancer cells over a gonadorelin-free MION/Mit-loaded liposome (Mit-ML) control, as well as in an LHRH receptor low-expressing Sloan-Kettering HER2 3+ Ovarian Cancer (SK-OV-3) cell control, thereby leading to high cytotoxicity against the MCF-7 human breast tumor cell line. The Mit-GML formulation was more effective and less toxic than equimolar doses of free Mit or Mit-ML in the treatment of LHRH receptors overexpressing MCF-7 breast cancer xenografts in mice. Furthermore, the Mit-GML demonstrated much higher T2 enhancement than did Mit-ML controls in vivo. Collectively, the study indicates that the integrated diagnostic and therapeutic design of Mit-GML nanomedicine potentially allows for the image-guided, target-specific treatment of cancer.

Design of multifunctional magnetic iron oxide nanoparticles/mitoxantrone-loaded liposomes for both magnetic resonance imaging and targeted cancer therapy

PubMed Central

He, Yingna; Zhang, Linhua; Zhu, Dunwan; Song, Cunxian

2014-01-01

Tumor-targeting multifunctional liposomes simultaneously loaded with magnetic iron oxide nanoparticles (MIONs) as a magnetic resonance imaging (MRI) contrast agent and anticancer drug, mitoxantrone (Mit), were developed for targeted cancer therapy and ultrasensitive MRI. The gonadorelin-functionalized MION/Mit-loaded liposome (Mit-GML) showed significantly increased uptake in luteinizing hormone–releasing hormone (LHRH) receptor overexpressing MCF-7 (Michigan Cancer Foundation-7) breast cancer cells over a gonadorelin-free MION/Mit-loaded liposome (Mit-ML) control, as well as in an LHRH receptor low-expressing Sloan-Kettering HER2 3+ Ovarian Cancer (SK-OV-3) cell control, thereby leading to high cytotoxicity against the MCF-7 human breast tumor cell line. The Mit-GML formulation was more effective and less toxic than equimolar doses of free Mit or Mit-ML in the treatment of LHRH receptors overexpressing MCF-7 breast cancer xenografts in mice. Furthermore, the Mit-GML demonstrated much higher T2 enhancement than did Mit-ML controls in vivo. Collectively, the study indicates that the integrated diagnostic and therapeutic design of Mit-GML nanomedicine potentially allows for the image-guided, target-specific treatment of cancer. PMID:25187709

MIT Laboratory for Computer Science Progress Report 20 - July 1982 - Jun 1983,

DTIC Science & Technology

1984-07-01

system by the Programming Technology Group. Research in the second and largest area entitled Machines, Languages , and Systems, strives to discover and...utilization and cost effectiveness . For example, the Programming Methodology Group and the Real Time Systems Group are developing languages and...100 Megabits per second when implemented with the 1.2[im. n- well cMOS process. 3. LANGUAGES 3.1. Demand Driven Evaluation In his engineer’s thesis

Architectural Options for a Future Deep Space Optical Communications Network

NASA Technical Reports Server (NTRS)

Edwards, B. L.; Benjamin, T.; Scozzafava, J.; Khatri, F.; Sharma, J.; Parvin, B.; Liebrecht, P. E.; Fitzgerald, R. J.

2004-01-01

This paper provides an overview of different options at Earth to provide Deep Space optical communication services. It is based mainly on work done for the Mars Laser Communications Demonstration (MLCD) Project, a joint project between NASA's Goddard Space Flight Center (GSFC), the Jet Propulsion Laboratory, California Institute of Technology (JPL), and the Massachusetts Institute of Technology Lincoln Laboratory (MIT/LL). It also reports preliminary conclusions from the Tracking and Data Relay Satellite System Continuation Study at GSFC. A lasercom flight terminal will be flown on the Mars Telecommunications Orbiter (MTO) to be launched by NASA in 2009, and will be the first high rate deep space demonstration of this revolutionary technology.

Quantum Statistics of the Toda Oscillator in the Wigner Function Formalism

NASA Astrophysics Data System (ADS)

Vojta, Günter; Vojta, Matthias

Classical and quantum mechanical Toda systems (Toda molecules, Toda lattices, Toda quantum fields) recently found growing interest as nonlinear systems showing solitons and chaos. In this paper the statistical thermodynamics of a system of quantum mechanical Toda oscillators characterized by a potential energy V(q) = Vo cos h q is treated within the Wigner function formalism (phase space formalism of quantum statistics). The partition function is given as a Wigner- Kirkwood series expansion in terms of powers of h2 (semiclassical expansion). The partition function and all thermodynamic functions are written, with considerable exactness, as simple closed expressions containing only the modified Hankel functions Ko and K1 of the purely imaginary argument i with = Vo/kT.Translated AbstractQuantenstatistik des Toda-Oszillators im Formalismus der Wigner-FunktionKlassische und quantenmechanische Toda-Systeme (Toda-Moleküle, Toda-Gitter, Toda-Quantenfelder) haben als nichtlineare Systeme mit Solitonen und Chaos in jüngster Zeit zunehmend an Interesse gewonnen. Wir untersuchen die statistische Thermodynamik eines Systems quantenmechanischer Toda-Oszillatoren, die durch eine potentielle Energie der Form V(q) = Vo cos h q charakterisiert sind, im Formalismus der Wigner-Funktion (Phasenraum-Formalismus der Quantenstatistik). Die Zustandssumme wird als Wigner-Kirkwood-Reihe nach Potenzen von h2 (semiklassische Entwicklung) dargestellt, und aus ihr werden die thermodynamischen Funktionen berechnet. Sämtliche Funktionen sind durch einfache geschlossene Formeln allein mit den modifizierten Hankel-Funktionen Ko und K1 des rein imaginären Arguments i mit = Vo/kT mit großer Genauigkeit darzustellen.

Sampling Technique for Robust Odorant Detection Based on MIT RealNose Data

NASA Technical Reports Server (NTRS)

Duong, Tuan A.

2012-01-01

This technique enhances the detection capability of the autonomous Real-Nose system from MIT to detect odorants and their concentrations in noisy and transient environments. The lowcost, portable system with low power consumption will operate at high speed and is suited for unmanned and remotely operated long-life applications. A deterministic mathematical model was developed to detect odorants and calculate their concentration in noisy environments. Real data from MIT's NanoNose was examined, from which a signal conditioning technique was proposed to enable robust odorant detection for the RealNose system. Its sensitivity can reach to sub-part-per-billion (sub-ppb). A Space Invariant Independent Component Analysis (SPICA) algorithm was developed to deal with non-linear mixing that is an over-complete case, and it is used as a preprocessing step to recover the original odorant sources for detection. This approach, combined with the Cascade Error Projection (CEP) Neural Network algorithm, was used to perform odorant identification. Signal conditioning is used to identify potential processing windows to enable robust detection for autonomous systems. So far, the software has been developed and evaluated with current data sets provided by the MIT team. However, continuous data streams are made available where even the occurrence of a new odorant is unannounced and needs to be noticed by the system autonomously before its unambiguous detection. The challenge for the software is to be able to separate the potential valid signal from the odorant and from the noisy transition region when the odorant is just introduced.

NASA X-Ray Observatory Completes Tests Under Harsh Simulated Space Conditions

NASA Astrophysics Data System (ADS)

1998-07-01

NASA's most powerful X-ray observatory has successfully completed a month-long series of tests in the extreme heat, cold, and airless conditions it will encounter in space during its five-year mission to shed new light on some of the darkest mysteries of the universe. The Advanced X-ray Astrophysics Facility was put through the rigorous testing as it was alternately heated and cooled in a special vacuum chamber at TRW Space and Electronics Group in Redondo Beach, Calif., NASA's prime contractor for the observatory. "Successful completion of thermal vacuum testing marks a significant step in readying the observatory for launch aboard the Space Shuttle in January," said Fred Wojtalik, manager of the Observatory Projects Office at NASA's Marshall Space Flight Center in Huntsville, Ala. "The observatory is a complex, highly sophisticated, precision instrument," explained Wojtalik. "We are pleased with the outcome of the testing, and are very proud of the tremendous team of NASA and contractor technicians, engineers and scientists that came together and worked hard to meet this challenging task." Testing began in May after the observatory was raised into the 60-foot thermal vacuum chamber at TRW. Testing was completed on June 20. During the tests the Advanced X-ray Astrophysics Facility was exposed to 232 degree heat and 195 degree below zero Fahrenheit cold. During four temperature cycles, all elements of the observatory - the spacecraft, telescope, and science instruments - were checked out. Computer commands directing the observatory to perform certain functions were sent from test consoles at TRW to all Advanced X-ray Astrophysics Facility components. A team of contractor and NASA engineers and scientists monitored and evaluated the results. Commands were also sent from, and test data monitored at, the Advanced X-ray Astrophysics Facility Operations Control Center in Cambridge, Mass., as part of the test series. The observatory will be managed and controlled from the Operations Control Center after launch. "As is usually the case, we identified a few issues to be resolved before launch," said Wojtalik. "Overall, however, the observatory performed exceptionally well." The observatory test team discovered a mechanical problem with one of the primary science instruments, the Imaging Spectrometer. A door protecting the instrument did not function when commanded by test controllers. "We do these tests to check and double check every aspect of satellite operation that could affect the ultimate success of the science mission," said Craig Staresinich, TRW Advanced X-ray Astrophysics Facility program manager. "Discovering a problem now is a success. Discovering a problem later, after launch, would be a failure." A team of NASA and contractor engineers are studying the mechanical problem and developing a plan to correct it. The instrument will be sent back to its builder, Lockheed-Martin Astronautics in Denver, Colo., where it will be repaired while the rest of the observatory continues other testing. This should still allow an on-time delivery of the observatory to NASA's Kennedy Space Center, Fla., in August, where it will be readied for launch in January. With a resolving power 10 times greater than previous X-ray telescopes, the new X-ray observatory will provide scientists with views of previously invisible X-ray sources, including black holes, exploding stars and interstellar gasses. The third of NASA's Great Observatories, it will join the Compton Gamma Ray Observatory and the Hubble Space Telescope in orbit. The Advanced X-ray Astrophysics Facility program is managed by the Marshall Center for the Office of Space Science, NASA Headquarters, Washington, D.C. TRW Space & Electronics Group is assembling the observatory and doing verification testing. The Advanced X-ray Astrophysics Facility Operations Control Center is operated by the Smithsonian Astrophysical Observatory. Using glass purchased from Schott Glaswerke, Mainz, Germany, the telescope's mirrors were built by Raytheon Optical Systems Inc., Danbury, Conn. The mirrors were coated by Optical Coating Laboratory, Inc., Santa Rosa, Calif., and assembled by EastmanKodak Co., Rochester, N.Y. The Advanced X-ray Astrophysics Facility Charge-Coupled Device Imaging Spectrometer was developed by Pennsylvania State University, University Park, Pa., and the Massachusetts Institute of Technology (MIT), Cambridge. One diffraction grating was developed by MIT, the other by the Space Research Organization Netherlands, Utrecht, Netherlands, in collaboration with the Max Planck Institute, Garching, Germany. The High Resolution Camera was built by the Smithsonian Astrophysical Observatory. Ball Aerospace & Technologies Corporation of Boulder, Colo., developed the aspect camera and the Science Instrument Module. Note to editors: Digital images to accompany this release are available via the World Wide Web at the following URL: http://chandra.harvard.edu/press/images.html

Multifunctional nanosheets based on hyaluronic acid modified graphene oxide for tumor-targeting chemo-photothermal therapy

NASA Astrophysics Data System (ADS)

Hou, Lin; Feng, Qianhua; Wang, Yating; Zhang, Huijuan; Jiang, Guixiang; Yang, Xiaomin; Ren, Junxiao; Zhu, Xiali; Shi, Yuyang; Zhang, Zhenzhong

2015-03-01

Graphene oxide (GO) with strong optical absorption in the near-infrared (NIR) region has shown great potential both in photothermal therapy and drug delivery. In this work, hyaluronic acid (HA)-functionalized GO (HA-GO) was successfully synthesized and controlled loading of mitoxantrone (MIT) onto HA-GO via π- π stacking interaction was investigated. The results revealed that drug-loaded nanosheets with high loading efficiency of 45 wt% exhibited pH-sensitive responses to tumor environment. Owing to the receptor-mediated endocytosis, cellular uptake analysis of HA-GO showed enhanced internalization. In vivo optical imaging test demonstrated that HA-GO nanosheets could enhance the targeting ability and residence time in tumor site. Moreover, the anti-tumor activity of free MIT, MIT/GO, and MIT/HA-GO in combination with NIR laser was investigated using human MCF-7 cells. In vitro cytotoxicity study revealed that HA-GO could stand as a biocompatible nanocarrier and MIT/HA-GO demonstrated remarkably higher toxicity than free MIT and MIT/GO, with IC50 of 0.79 µg ml-1. Tumor cell-killing potency was enhanced when MIT/HA-GO were combined with NIR irradiation, and the IC50 of MIT/HA-GO plus laser irradiation was 0.38 µg ml-1. In vivo, MIT/HA-GO plus NIR laser irradiation with the tumor growth inhibition of 93.52 % displayed greater anti-tumor effect compared with free MIT and MIT/GO with or without laser irradiation. Therefore, the MIT/HA-GO nanosheets may potentially be useful for further development of synergistic cancer therapy.

Nested Focusing Optics for Compact Neutron Sources

NASA Technical Reports Server (NTRS)

Nabors, Sammy A.

2015-01-01

NASA's Marshall Space Flight Center, the Massachusetts Institute of Technology (MIT), and the University of Alabama Huntsville (UAH) have developed novel neutron grazing incidence optics for use with small-scale portable neutron generators. The technology was developed to enable the use of commercially available neutron generators for applications requiring high flux densities, including high performance imaging and analysis. Nested grazing incidence mirror optics, with high collection efficiency, are used to produce divergent, parallel, or convergent neutron beams. Ray tracing simulations of the system (with source-object separation of 10m for 5 meV neutrons) show nearly an order of magnitude neutron flux increase on a 1-mm diameter object. The technology is a result of joint development efforts between NASA and MIT researchers seeking to maximize neutron flux from diffuse sources for imaging and testing applications.

A long-term space astrophysics research program: An x-ray perspective of the components and structure of galaxies

NASA Technical Reports Server (NTRS)

Fabbiano, G.

1995-01-01

X-ray studies of galaxies by the Smithsonian Astrophysical Observatory (SAO) and MIT are described. Activities at SAO include ROSAT PSPC x-ray data reduction and analysis pipeline; x-ray sources in nearby Sc galaxies; optical, x-ray, and radio study of ongoing galactic merger; a radio, far infrared, optical, and x-ray study of the Sc galaxy NGC247; and a multiparametric analysis of the Einstein sample of early-type galaxies. Activities at MIT included continued analysis of observations with ROSAT and ASCA, and continued development of new approaches to spectral analysis with ASCA and AXAF. Also, a new method for characterizing structure in galactic clusters was developed and applied to ROSAT images of a large sample of clusters. An appendix contains preprints generated by the research.

Multifunctional hyaluronic acid modified graphene oxide loaded with mitoxantrone for overcoming drug resistance in cancer

NASA Astrophysics Data System (ADS)

Hou, Lin; Feng, Qianhua; Wang, Yating; Yang, Xiaomin; Ren, Junxiao; Shi, Yuyang; Shan, Xiaoning; Yuan, Yujie; Wang, Yongchao; Zhang, Zhenzhong

2016-01-01

Multifunctional nanosheets (HA-GO/Pluronic) with targeted chemo-photothermal properties were successfully developed for controlled delivery of mitoxantrone (MIT) to overcome multidrug resistance (MDR). In vitro release profiles displayed that both an acidic environment and a NIR laser could trigger and accelerate the release of a drug, which ensured nanosheets were stable in blood circulation and released MIT within tumor cells under laser irradiation. HA-GO/Pluronic nanosheets were taken up into MCF-7/ADR cells via receptor-mediated endocytosis, which further facilitated escapement of P-gp efflux. Compared with MIT solution, MIT/HA-GO/Pluronic showed greater cytotoxicity and increase in cellular MIT accumulation in MCF-7/ADR cells. Cell apoptosis and cell cycle arrest studies also revealed that MIT/HA-GO/Pluronic was more potent than MIT/GO/Pluronic and MIT solution. The anticancer efficacy in vivo was evaluated in MCF-7 and MCF-7/ADR-bearing mice, and inhibition of tumors by MIT/HA-GO/Pluronic with NIR laser irradiation was the most effective among all MIT formulations. In summary, the MIT/HA-GO/Pluronic system had striking functions such as P-gp reversible inhibitor and anticancer efficacy, and could present a promising platform for drug-resistant cancer treatment.

MIT domain of Vps4 is a Ca2+-dependent phosphoinositide-binding domain.

PubMed

Iwaya, Naoko; Takasu, Hirotoshi; Goda, Natsuko; Shirakawa, Masahiro; Tanaka, Toshiki; Hamada, Daizo; Hiroaki, Hidekazu

2013-05-01

The microtubule interacting and trafficking (MIT) domain is a small protein module that is conserved in proteins of diverged function, such as Vps4, spastin and sorting nexin 15 (SNX15). The molecular function of the MIT domain is protein-protein interaction, in which the domain recognizes peptides containing MIT-interacting motifs. Recently, we identified an evolutionarily related domain, 'variant' MIT domain at the N-terminal region of the microtubule severing enzyme katanin p60. We found that the domain was responsible for binding to microtubules and Ca(2+). Here, we have examined whether the authentic MIT domains also bind Ca(2+). We found that the loop between the first and second α-helices of the MIT domain binds a Ca(2+) ion. Furthermore, the MIT domains derived from Vps4b and SNX15a showed phosphoinositide-binding activities in a Ca(2+)-dependent manner. We propose that the MIT domain is a novel membrane-associating domain involved in endosomal trafficking.

Human factors in space telepresence

NASA Technical Reports Server (NTRS)

Akin, D. L.; Howard, R. D.; Oliveria, J. S.

1983-01-01

The problems of interfacing a human with a teleoperation system, for work in space are discussed. Much of the information presented here is the result of experience gained by the M.I.T. Space Systems Laboratory during the past two years of work on the ARAMIS (Automation, Robotics, and Machine Intelligence Systems) project. Many factors impact the design of the man-machine interface for a teleoperator. The effects of each are described in turn. An annotated bibliography gives the key references that were used. No conclusions are presented as a best design, since much depends on the particular application desired, and the relevant technology is swiftly changing.

Helicobacter sp. MIT 01-6451 infection during fetal and neonatal life in laboratory mice.

PubMed

Yamanaka, Hitoki; Nakanishi, Tai; Takagi, Toshikazu; Ohsawa, Makiko; Kubo, Noriaki; Yamamoto, Naoto; Takemoto, Takahira; Ohsawa, Kazutaka

2015-01-01

Helicobacter sp. MIT 01-6451 has been detected in SPF mice kept in Japan. To characterize strain MIT 01-6451, its infection route during fetal and neonatal life and effects on pregnancy were investigated using immunocompetent and immunodeficient mouse strains (BALB/c, C57BL/6, and SCID). MIT 01-6451 was detected in the uterus, vagina, and mammary glands of 50% of infected SCID mice, whereas these tissues were all negative in immunocompetent mice. No fetal infections with MIT 01-6451 were detected at 16-18 days after pregnancy in any mouse strain. In newborn mice, MIT 01-6451 was detected in intestinal tissue of C57BL/6 and SCID mice at 9-11 days after birth, but not in BALB/c mice. The IgA and IgG titers to MIT 01-6451 in sera of C57BL/6 female mice were significantly lower than those of BALB/c mice. Although no significant differences in the number of newborns per litter were observed between MIT 01-6451-infected and MIT 01-6451-free dams, the birth rate was lower in infected SCID mice than in control SCID mice. The present results indicated that MIT 01-6451 infects newborn mice after birth rather than by vertical transmission to the fetus via the placenta and that MIT 01-6451 infection shows opportunistically negative effects on the birth rate. In addition, the maternal immune response may affect infection of newborn mice with MIT 01-6451 through breast milk.

Vitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity

PubMed Central

Liu, Yuling; Xu, Yingqi; Wu, Minghui; Fan, Lijiao; He, Chengwei; Wan, Jian-Bo; Li, Peng; Chen, Meiwan; Li, Hui

2016-01-01

Mitoxantrone (MIT) is a chemotherapeutic agent with promising anticancer efficacy. In this study, Pluronic F68-vitamine E succinate (F68-VES) amphiphilic polymer micelles were developed for delivering MIT and enhancing its anticancer activity. MIT-loaded F68–VES (F68–VES/MIT) micelles were prepared via the solvent evaporation method with self-assembly under aqueous conditions. F68–VES/MIT micelles were found to be of optimal particle size with the narrow size distribution. Transmission electron microscopy images of F68–VES/MIT micelles showed homogeneous spherical shapes and smooth surfaces. F68–VES micelles had a low critical micelle concentration value of 3.311 mg/L, as well as high encapsulation efficiency and drug loading. Moreover, F68–VES/MIT micelles were stable in the presence of fetal bovine serum for 24 hours and maintained sustained drug release in vitro. Remarkably, the half maximal inhibitory concentration (IC50) value of F68–VES/MIT micelles was lower than that of free MIT in both MDA-MB-231 and MCF-7 cells (two human breast cancer cell lines). In addition, compared with free MIT, there was an increased trend of apoptosis and cellular uptake of F68–VES/MIT micelles in MDA-MB-231 cells. Taken together, these results indicated that F68–VES polymer micelles were able to effectively deliver MIT and largely improve its potency in cancer therapy. PMID:27471384

Asteroid Detection Results Using the Space Surveillance Telescope

NASA Astrophysics Data System (ADS)

Ruprecht, Jessica D.; Ushomirsky, Gregory; Woods, Deborah F.; Viggh, Herbert E. M.; Varey, Jacob; Cornell, Mark E.; Stokes, Grant

2015-11-01

From 1998-2013, MIT Lincoln Laboratory operated a highly successful near-Earth asteroid search program using two 1-m optical telescopes located at the MIT Lincoln Laboratory Experimental Test Site (ETS) in Socorro, N.M. In 2014, the Lincoln Near-Earth Asteroid Research (LINEAR) program successfully transitioned operations from the two 1-m telescopes to the 3.5-m Space Surveillance Telescope (SST) located at Atom Site on White Sands Missile Range, N.M. This paper provides a summary of first-year performance and results for the LINEAR program with SST and provides an update on recent improvements to the moving-object pipeline architecture that increase utility of SST data for NEO discovery and improve sensitivity to fast-moving objects. Ruprecht et al. (2014) made predictions for SST NEO search productivity as a function of population model. This paper assesses the NEO search performance of SST in the first 1.5 years of operation and compares results to model predictions.This work is sponsored by the Defense Advanced Research Projects Agency and the National Aeronautics and Space Administration under Air Force Contract #FA8721-05-C-0002. The views, opinions, and/or findings contained in this article/presentation are those of the authors / presenters and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. Distribution Statement A: Approved for public release, distribution unlimited.

Asteroid Detection Results Using the Space Surveillance Telescope

NASA Astrophysics Data System (ADS)

Ruprecht, J.; Ushomirsky, G.; Woods, D.; Viggh, H.; Varey, J.; Cornell, M.; Stokes, G.

From 1998-2013, MIT Lincoln Laboratory operated a highly successful near-Earth asteroid search program using two 1-m optical telescopes located at the MIT Lincoln Laboratory Experimental Test Site (ETS) in Socorro, N.M. In 2014, the Lincoln Near-Earth Asteroid Research (LINEAR) program successfully transitioned operations from the two 1-m telescopes to the 3.5-m Space Surveillance Telescope (SST) located at Atom Site on White Sands Missile Range, N.M. This paper provides a summary of first-year performance and results for the LINEAR program with SST and provides an update on recent improvements to the moving-object pipeline architecture that increase utility of SST data for NEO discovery and improve sensitivity to fast-moving objects. Ruprecht et al. (2014) made predictions for SST NEO search productivity as a function of population model. This paper assesses the NEO search performance of SST in the first 1.5 years of operation and compares results to model predictions. This work is sponsored by the Defense Advanced Research Projects Agency and the National Aeronautics and Space Administration under Air Force Contract #FA8721-05-C-0002. The views, opinions, and/or findings contained in this article/presentation are those of the authors / presenters and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. Distribution Statement A: Approved for public release, distribution unlimited.

Representation

DTIC Science & Technology

2006-09-01

two weeks to arrive. Source: http://beergame.mit.edu/ Permission Granted – MIT Supply Chain Forum 2005 Professor Sterman –Sloan School of...Management - MITSource: http://web.mit.edu/jsterman/www/ SDG /beergame.html Rules of Engagement The MIT Beer Game Simulation 04-04 Slide Number 10 Professor...Sterman –Sloan School of Management - MITSource: http://web.mit.edu/jsterman/www/ SDG /beergame.html What is the Significance of Representation

Educational Outreach at the MIT Plasma Science and Fusion Center

NASA Astrophysics Data System (ADS)

Thomas, P.; Rivenberg, P.; Censabella, V.

2002-11-01

At the MIT PSFC, student and staff volunteers work together to increase the public's knowledge of fusion science and plasma technology. Seeking to generate excitement in young people about science and engineering, the PSFC hosts a number of educational outreach activities throughout the year, including Middle and High School Outreach Days. The PSFC also has an in-school science-demonstration program on the theme of magnetism. As ``Mr. Magnet," Technical Supervisor Paul Thomas brings a truck-load of hands-on demonstrations to K-12 schools, challenging students to help him with experiments. While teaching fundamentals of magnetism and electricity he shows that science is fun for all, and that any student can have a career in science. This year he reached 82 schools -- 30,000 teachers and students. He has recently expanded his teaching to include an interactive demonstration of plasma, encouraging participants to investigate plasma properties with audiovisual, electromagnetic, and spectroscopic techniques. He has also developed a workshop for middle school on how to build an electromagnet.

Southeast Asian Space Programs: Motives, Cooperation, and Competition

DTIC Science & Technology

2014-09-01

LEO low Earth orbit MTCR Missile Technology Control Regime NAMRIA National Mapping and Resource Information Authority NASA National Aeronautics and...Technology’s role 27 Leo Marx and Merritt Roe Smith, “Introduction,” in Does Technology Drive History: The...Dilemma of Technological Determinism, ed. Merritt Roe Smith and Leo Marx (Cambridge, MA: The MIT Press, 1994), xii. 28 Donald MacKenzie and Judy

AGARD Flight Test Instrumentation Series. Volume 11. Pressure and Flow Measurement

DTIC Science & Technology

1980-07-01

Unempfindlichkeit gegen Schrdg- anstr~ mung . Luftfo-ahrtforschung V (1935), S.75-79. 35. Winternitz, F.A.L. Cantilevered pitot cylinder. The Engineer 199 (1955), pp...cur Str ~mungsmessung. Z.far Instrumentenkunde 71 (1963) 7, 187-197. 42. Davies, P.O.A.L. The behavior of a pitot tube in transverse shear. J. Fluid...Ober den Einflug der Kompressibilitit auf die Druckan-eige eines Prandtl-Rohres bei Str ~mungen mit Unterschallgeschwin- digkeit. Jahrbuch der

Architecture-Led Safety Analysis of the Joint Multi-Role (JMR) Joint Common Architecture (JCA) Demonstration System

DTIC Science & Technology

2015-12-01

relevant system components (i.e., their component type declarations) have been anno - tated with EMV2 error source or propagation declarations and hazard...contributors. They are recorded as EMV2 anno - tations for each of the ASSA. Figure 40 shows a sampling of potential hazard contributors by the functional...2012] Leveson, N., Engineering a Safer World. MIT Press. 2012. [Parnas 1991] Parnas, D. & Madey, J . Functional Documentation for Computer Systems

Combustion Characteristics Analysis of Improved Combustor Structure of Micro Turbine Engine

NASA Astrophysics Data System (ADS)

Chen, Hai

2018-05-01

In order to improve the performance of micro combustor, the 60 slots of the original combustor were modified into 120 slots for the MIT 6-wafer micro-combustor. The performance of the micro combustor with the improved and original design was compared through numerical simulation, and stable operating ranges was studied. It was found that the improved combustor can stabilize the flame under the condition of higher fuel/air mixture mass flow rate.

A Systems Engineering Process for an Integrated Structural Health Monitoring System

DTIC Science & Technology

2007-03-01

York NY, 1999. 2nd ed. 3. Chambers, Jeffrey T., Brian L. Wardle, and Seth S. Kessler . “Durability Assessment of Lamb Wave-Based Structural Health...Institute of Technology, 1960. 222 Bibliography 10. Kessler , Seth S., S. Mark Spearing, Mauro J. Atalla, Carlos E. S. Cesnik, and Constantinos...Materials, March 4-8 2001, Newport Beach, CA. Available at http://web.mit.edu/sskess/www/papers/SPIE01.pdf. 11. Kessler , Seth S., S. Mark Spearing

Life Forecasting as a Logistics Technique.

DTIC Science & Technology

1982-01-01

Two examples of RCM applications were investigated directly by the MIT project team: the T53-L-13B engine for the UH -lH Helicopter and the M- 60 Tank...for RCM activities. The candidate systems and the respective 4 readiness commands were the UH -lH helicopter (TSARCOM), TOY Weapon System (MIRCOM), M...have capability for developing Failure Modes and Effects Analyses ( FMEA ). 5. Accurate and dependable field or test data are generally not available. 6

Mithramycin-loaded mPEG-PLGA nanoparticles exert potent antitumor efficacy against pancreatic carcinoma

PubMed Central

Liu, Xu-Jie; Li, Liang; Liu, Xiu-Jun; Li, Yi; Zhao, Chun-Yan; Wang, Rui-Qi; Zhen, Yong-Su

2017-01-01

Previous studies have shown that mithramycin A (MIT) is a promising candidate for the treatment of pancreatic carcinoma through inhibiting transcription factor Sp1. However, systemic toxicities may limit its clinical application. Here, we report a rationally designed formulation of MIT-loaded nanoparticles (MIT-NPs) with a small size and sustained release for improved passive targeting and enhanced therapeutic efficacy. Nearly spherical MIT-NPs with a mean particle size of 25.0±4.6 nm were prepared by encapsulating MIT into methoxy poly(ethylene glycol)-block-poly(d,l-lactic-co-glycolic acid) (mPEG-PLGA) nanoparticles (NPs) with drug loading of 2.11%±0.51%. The in vitro release of the MIT-NPs lasted for >48 h with a sustained-release pattern. The cytotoxicity of MIT-NPs to human pancreatic cancer BxPC-3 and MIA Paca-2 cells was comparable to that of free MIT. Determined by flow cytometry and confocal microscopy, the NPs internalized into the cells quickly and efficiently, reaching the peak level at 1–2 h. In vivo fluorescence imaging showed that the prepared NPs were gradually accumulated in BxPC-3 and MIA Paca-2 xenografts and retained for 168 h. The fluorescence intensity in both BxPC-3 and MIA Paca-2 tumors was much stronger than that of various tested organs. Therapeutic efficacy was evaluated with the poorly permeable BxPC-3 pancreatic carcinoma xenograft model. At a well-tolerated dose of 2 mg/kg, MIT-NPs suppressed BxPC-3 tumor growth by 96%. Compared at an equivalent dose, MIT-NPs exerted significantly higher therapeutic effect than free MIT (86% versus 51%, P<0.01). Moreover, the treatment of MIT and MIT-NPs reduced the expression level of oncogene c-Myc regulated by Sp1, and notably, both of them decreased the protein level of CD47. In summary, the novel formulation of MIT-NPs shows highly therapeutic efficacy against pancreatic carcinoma xenograft. In addition, MIT-NPs can downregulate CD47 expression, implying that it might play a positive role in cancer immunotherapy. PMID:28769562

Helicobacter sp. MIT 01-6451 infection during fetal and neonatal life in laboratory mice

PubMed Central

Yamanaka, Hitoki; Nakanishi, Tai; Takagi, Toshikazu; Ohsawa, Makiko; Kubo, Noriaki; Yamamoto, Naoto; Takemoto, Takahira; Ohsawa, Kazutaka

2015-01-01

Helicobacter sp. MIT 01-6451 has been detected in SPF mice kept in Japan. To characterize strain MIT 01-6451, its infection route during fetal and neonatal life and effects on pregnancy were investigated using immunocompetent and immunodeficient mouse strains (BALB/c, C57BL/6, and SCID). MIT 01-6451 was detected in the uterus, vagina, and mammary glands of 50% of infected SCID mice, whereas these tissues were all negative in immunocompetent mice. No fetal infections with MIT 01-6451 were detected at 16–18 days after pregnancy in any mouse strain. In newborn mice, MIT 01-6451 was detected in intestinal tissue of C57BL/6 and SCID mice at 9–11 days after birth, but not in BALB/c mice. The IgA and IgG titers to MIT 01-6451 in sera of C57BL/6 female mice were significantly lower than those of BALB/c mice. Although no significant differences in the number of newborns per litter were observed between MIT 01-6451-infected and MIT 01-6451-free dams, the birth rate was lower in infected SCID mice than in control SCID mice. The present results indicated that MIT 01-6451 infects newborn mice after birth rather than by vertical transmission to the fetus via the placenta and that MIT 01-6451 infection shows opportunistically negative effects on the birth rate. In addition, the maternal immune response may affect infection of newborn mice with MIT 01-6451 through breast milk. PMID:26134357

Around Marshall

NASA Image and Video Library

1980-07-08

Once the United States' space program had progressed from Earth's orbit into outerspace, the prospect of building and maintaining a permanent presence in space was realized. To accomplish this feat, NASA launched a temporary workstation, Skylab, to discover the effects of low gravity and weightlessness on the human body, and also to develop tools and equipment that would be needed in the future to build and maintain a more permanent space station. The structures, techniques, and work schedules had to be carefully designed to fit this unique construction site. The components had to be lightweight for transport into orbit, yet durable. The station also had to be made with removable parts for easy servicing and repairs by astronauts. All of the tools necessary for service and repairs had to be designed for easy manipulation by a suited astronaut. And construction methods had to be efficient due to limited time the astronauts could remain outside their controlled environment. In lieu of all the specific needs for this project, an environment on Earth had to be developed that could simulate a low gravity atmosphere. A Neutral Buoyancy Simulator (NBS) was constructed by NASA Marshall Space Flight Center (MSFC) in 1968. Since then, NASA scientists have used this facility to understand how humans work best in low gravity and also provide information about the different kinds of structures that can be built. Pictured is a Massachusetts Institute of Technology (MIT) student working in a spacesuit on the Experimental Assembly of Structures in Extravehicular Activity (EASE) project which was developed as a joint effort between MFSC and MIT. The EASE experiment required that crew members assemble small components to form larger components, working from the payload bay of the space shuttle.

The effect of averaging adjacent planes for artifact reduction in matrix inversion tomosynthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Godfrey, Devon J.; Page McAdams, H.; Dobbins, James T. III

2013-02-15

Purpose: Matrix inversion tomosynthesis (MITS) uses linear systems theory and knowledge of the imaging geometry to remove tomographic blur that is present in conventional backprojection tomosynthesis reconstructions, leaving in-plane detail rendered clearly. The use of partial-pixel interpolation during the backprojection process introduces imprecision in the MITS modeling of tomographic blur, and creates low-contrast artifacts in some MITS planes. This paper examines the use of MITS slabs, created by averaging several adjacent MITS planes, as a method for suppressing partial-pixel artifacts. Methods: Human chest tomosynthesis projection data, acquired as part of an IRB-approved pilot study, were used to generate MITS planes,more » three-plane MITS slabs (MITSa3), five-plane MITS slabs (MITSa5), and seven-plane MITS slabs (MITSa7). These were qualitatively examined for partial-pixel artifacts and the visibility of normal and abnormal anatomy. Additionally, small (5 mm) subtle pulmonary nodules were simulated and digitally superimposed upon human chest tomosynthesis projection images, and their visibility was qualitatively assessed in the different reconstruction techniques. Simulated images of a thin wire were used to generate modulation transfer function (MTF) and slice-sensitivity profile curves for the different MITS and MITS slab techniques, and these were examined for indications of partial-pixel artifacts and frequency response uniformity. Finally, mean-subtracted, exposure-normalized noise power spectra (ENNPS) estimates were computed and compared for MITS and MITS slab reconstructions, generated from 10 sets of tomosynthesis projection data of an acrylic slab. The simulated in-plane MTF response of each technique was also combined with the square root of the ENNPS estimate to yield stochastic signal-to-noise ratio (SNR) information about the different reconstruction techniques. Results: For scan angles of 20 Degree-Sign and 5 mm plane separation, seven MITS planes must be averaged to sufficiently remove partial-pixel artifacts. MITSa7 does appear to subtly reduce the contrast of high-frequency 'edge' information, but the removal of partial-pixel artifacts makes the appearance of low-contrast, fine-detail anatomy even more conspicuous in MITSa7 slices. MITSa7 also appears to render simulated subtle 5 mm pulmonary nodules with greater visibility than MITS alone, in both the open lung and regions overlying the mediastinum. Finally, the MITSa7 technique reduces stochastic image variance, though the in-plane stochastic SNR (for very thin objects which do not span multiple MITS planes) is only improved at spatial frequencies between 0.05 and 0.20 cycles/mm. Conclusions: The MITSa7 method is an improvement over traditional single-plane MITS for thoracic imaging and the pulmonary nodule detection task, and thus the authors plan to use the MITSa7 approach for all future MITS research at the authors' institution.« less

The effect of averaging adjacent planes for artifact reduction in matrix inversion tomosynthesis.

PubMed

Godfrey, Devon J; McAdams, H Page; Dobbins, James T

2013-02-01

Matrix inversion tomosynthesis (MITS) uses linear systems theory and knowledge of the imaging geometry to remove tomographic blur that is present in conventional backprojection tomosynthesis reconstructions, leaving in-plane detail rendered clearly. The use of partial-pixel interpolation during the backprojection process introduces imprecision in the MITS modeling of tomographic blur, and creates low-contrast artifacts in some MITS planes. This paper examines the use of MITS slabs, created by averaging several adjacent MITS planes, as a method for suppressing partial-pixel artifacts. Human chest tomosynthesis projection data, acquired as part of an IRB-approved pilot study, were used to generate MITS planes, three-plane MITS slabs (MITSa3), five-plane MITS slabs (MITSa5), and seven-plane MITS slabs (MITSa7). These were qualitatively examined for partial-pixel artifacts and the visibility of normal and abnormal anatomy. Additionally, small (5 mm) subtle pulmonary nodules were simulated and digitally superimposed upon human chest tomosynthesis projection images, and their visibility was qualitatively assessed in the different reconstruction techniques. Simulated images of a thin wire were used to generate modulation transfer function (MTF) and slice-sensitivity profile curves for the different MITS and MITS slab techniques, and these were examined for indications of partial-pixel artifacts and frequency response uniformity. Finally, mean-subtracted, exposure-normalized noise power spectra (ENNPS) estimates were computed and compared for MITS and MITS slab reconstructions, generated from 10 sets of tomosynthesis projection data of an acrylic slab. The simulated in-plane MTF response of each technique was also combined with the square root of the ENNPS estimate to yield stochastic signal-to-noise ratio (SNR) information about the different reconstruction techniques. For scan angles of 20° and 5 mm plane separation, seven MITS planes must be averaged to sufficiently remove partial-pixel artifacts. MITSa7 does appear to subtly reduce the contrast of high-frequency "edge" information, but the removal of partial-pixel artifacts makes the appearance of low-contrast, fine-detail anatomy even more conspicuous in MITSa7 slices. MITSa7 also appears to render simulated subtle 5 mm pulmonary nodules with greater visibility than MITS alone, in both the open lung and regions overlying the mediastinum. Finally, the MITSa7 technique reduces stochastic image variance, though the in-plane stochastic SNR (for very thin objects which do not span multiple MITS planes) is only improved at spatial frequencies between 0.05 and 0.20 cycles∕mm. The MITSa7 method is an improvement over traditional single-plane MITS for thoracic imaging and the pulmonary nodule detection task, and thus the authors plan to use the MITSa7 approach for all future MITS research at the authors' institution.

Chinese Space Program for Heliophysics

NASA Astrophysics Data System (ADS)

Wu, Ji; Gan, Weiqun; Wang, Chi; Liu, Weining; Yan, Yihua; Liu, Yong; Sun, Lilin; Liu, Ying

As one of the major field of space science, heliophysics research in China has not only long history but also strong research forces. Many space missions have been proposed by the community but with few got support. Since 2006, Chinese Academy of Science has organized a long term strategic study in space science. In 2011, the space science program has been kicked off with several new missions being selected for Phase A study. In this presentation, first a brief review on past programs, such as Double Star, Chang’e, and an introduction on the space science strategic study are given. Under the guidance of this strategic study or roadmap, a few missions have been proposed or re-proposed with new element, such as DSO, KUAFU, MIT, SPORT and ASO-S. Brief introductions of these programs and their current status will be given.

Brute-force mapmaking with compact interferometers: a MITEoR northern sky map from 128 to 175 MHz

NASA Astrophysics Data System (ADS)

Zheng, H.; Tegmark, M.; Dillon, J. S.; Liu, A.; Neben, A. R.; Tribiano, S. M.; Bradley, R. F.; Buza, V.; Ewall-Wice, A.; Gharibyan, H.; Hickish, J.; Kunz, E.; Losh, J.; Lutomirski, A.; Morgan, E.; Narayanan, S.; Perko, A.; Rosner, D.; Sanchez, N.; Schutz, K.; Valdez, M.; Villasenor, J.; Yang, H.; Zarb Adami, K.; Zelko, I.; Zheng, K.

2017-03-01

We present a new method for interferometric imaging that is ideal for the large fields of view and compact arrays common in 21 cm cosmology. We first demonstrate the method with the simulations for two very different low-frequency interferometers, the Murchison Widefield Array and the MIT Epoch of Reionization (MITEoR) experiment. We then apply the method to the MITEoR data set collected in 2013 July to obtain the first northern sky map from 128 to 175 MHz at ∼2° resolution and find an overall spectral index of -2.73 ± 0.11. The success of this imaging method bodes well for upcoming compact redundant low-frequency arrays such as Hydrogen Epoch of Reionization Array. Both the MITEoR interferometric data and the 150 MHz sky map are available at http://space.mit.edu/home/tegmark/omniscope.html.

Tolerance and resistance characteristics of microalgae Scenedesmus sp. LX1 to methylisothiazolinone.

PubMed

Wang, Xiao-Xiong; Zhang, Tian-Yuan; Dao, Guo-Hua; Hu, Hong-Ying

2018-05-25

Methylisothiazolinone (MIT) has been widely used to control bacterial growth in reverse osmosis (RO) systems. However, MIT's toxicity on microalgae should be determined because residual MIT is concentrated into RO concentrate (ROC) and might have a severe impact on microalgae-based ROC treatment. This study investigated the tolerance of Scenedesmus sp. LX1 to MIT and revealed the mechanism of algal growth inhibition and toxicity resistance. Scenedesmus sp. LX1 was inhibited by MIT with a half-maximal effective concentration at 72 h (72 h-EC 50 ) of 1.00 mg/L, but the strain recovered from the inhibition when its growth was not completely inhibited. It was observed that this inhibition's effect on subsequent growth was weak, and the removal of MIT was the primary reason for the recovery. Properly increasing the initial algal density significantly shortened the adaptation time for accelerated recovery in a MIT-containing culture. Photosynthesis damage by MIT was one of the primary reasons for growth inhibition, but microalgal cell respiration and adenosine triphosphate (ATP) synthesis were not completely inhibited, and the algae were still alive even when growth was completely inhibited, which was notably different from observations made with bacteria and fungi. The algae synthesized more chlorophyll, antioxidant enzymes of superoxide dismutase (SOD) and catalase (CAT), and small molecules, such as reduced glutathione (GSH), to resist MIT poisoning. The microalgae-based process could treat the MIT-containing ROC, since MIT was added for only several hours a week in municipal wastewater reclamation RO processes, and the MIT average concentration was considerably lower than the maximum concentration that algae could tolerate. Copyright © 2018. Published by Elsevier Ltd.

The development of form two mathematics i-Think module (Mi-T2)

NASA Astrophysics Data System (ADS)

Yao, Foo Jing; Abdullah, Mohd Faizal Nizam Lee; Tien, Lee Tien

2017-05-01

This study aims to develop a training module i-THINK Mathematics Form Two (Mi-T2) to increase the higher-order thinking skills of students. The Mi-T2 training module was built based on the Sidek Module Development Model (2001). Constructivist learning theory, cognitive learning theory, i-THINK map and higher order thinking skills were the building blocks of the module development. In this study, researcher determined the validity and reliability of Mi-T2 module. The design being used in this study was descriptive study. To determine the needs of Mi-T2 module, questionnaires and literature review were used to collect data. When the need of the module was determined, the module was built and a pilot study was conducted to test the reliability of the Mi-T2 module. The pilot study was conducted at a secondary school in North Kinta, Perak. A Form Two class was selected to be the sample study through clustered random sampling. The pilot study was conducted for two months and one topic had been studied. The Mi-T2 module was evaluated by five expert panels to determine the content validity of the module. The instruments being used in the study were questionnaires about the necessity of the Mi-T2 module for guidance, questionnaires about the validity of the module and questionnaires concerning the reliability of the module. Statistical analysis was conducted to determine the validity and reliability coefficients of the Mi-T2 module. The content validity of Mi-T2 module was determined by Cohen's Kappa's (1968) agreement coefficient and the reliability of Mi-T2 module was determined by Cronbach Alpha's value scale. The content validity of Mi-T2 module was 0.89 and the Cronbach Alpha's value of Mi-T2 module was 0.911.

Methylisothiazolinone toxicity and inhibition of wound healing and regeneration in planaria.

PubMed

Van Huizen, Alanna V; Tseng, Ai-Sun; Beane, Wendy S

2017-10-01

Methylisothiazolinone (MIT) is a common biocide used in cosmetic and industrial settings. Studies have demonstrated that MIT is a human sensitizer, to the extent that in 2013 MIT was named allergen of the year. Recently, we showed that MIT exposure in Xenopus laevis (the African clawed frog) inhibits wound healing and tail regeneration. However, it is unknown whether MIT affects these processes in other animals. Here, we investigated the effects of MIT exposure in planaria-non-parasitic freshwater flatworms able to regenerate all tissues after injury. Using a common research strain of Dugesia japonica, we determined that intact planarians exposed to 15μM MIT displayed both neuromuscular and epithelial-integrity defects. Furthermore, regenerating (head and tail) fragments exposed to 15μM MIT failed to close wounds or had significantly delayed wound healing. Planarian wounds normally close within 1h after injury. However, most MIT-exposed animals retained open wounds at 24h and subsequently died, and those few animals that were able to undergo delayed wound healing without dying exhibited abnormal regeneration. For instance, head regeneration was severely delayed or inhibited, with anterior structures such as eyes failing to form in newly produced tissues. These data suggest that MIT directly affects both wound healing and regeneration in planarians. Next, we investigated the ability of thiol-containing antioxidants to rescue planarian wound closure during MIT exposure. The data reveal both n-acetyl cysteine and glutathione were each able to fully rescue MIT inhibition of wound healing. Lastly, we established MIT toxicity levels by determining the LC 50 of 5 different planarian species: D. japonica, Schmidtea mediterranea, Girardia tigrina, Girardia dorotocephala, and Phagocata gracilis. Our LC 50 data revealed that concentrations as low as 39μM (4.5ppm) are lethal to planarians, with concentrations of just 5μM inhibiting wound healing, and suggest that phylogeny is predictive of species toxicity levels. Together these results indicate MIT may have broad wound healing effects on aquatic species in general and are not limited to X. laevis alone. Future studies should investigate the impact of MIT on wound healing in other organisms, including non-aquatic organisms and mammals. Copyright © 2017 Elsevier B.V. All rights reserved.

ASTRONAUT COOPER, GORDON L. - TRAINING - MERCURY-ATLAS (MA)-9 - CAMERA

NASA Image and Video Library

1963-03-01

S63-03952 (1963) --- Astronaut L. Gordon Cooper Jr. explains the 16mm handheld spacecraft camera to his backup pilot astronaut Alan Shepard. The camera, designed by J.R. Hereford of McDonnell Aircraft Corp., will be used by Cooper during the Mercury-Atlas 9 (MA-9) mission to photograph experiments in space for M.I.T. and the Weather Bureau. Photo credit: NASA

Shaping and Being Shaped by Environments for Learning Science: Continuities with the Space and Democratic Vision of a Century Ago

ERIC Educational Resources Information Center

Cavicchi, Elizabeth

2017-01-01

Environments of learning often remain unnoticed and unacknowledged. This study follows a student and myself as we became aware of our local environment at MIT and welcomed that environment as a vibrant contributor to our learning. We met this environment in part through its educational heritage in two centennial anniversaries: John Dewey's 1916…

Mit1 Transcription Factor Mediates Methanol Signaling and Regulates the Alcohol Oxidase 1 (AOX1) Promoter in Pichia pastoris.

PubMed

Wang, Xiaolong; Wang, Qi; Wang, Jinjia; Bai, Peng; Shi, Lei; Shen, Wei; Zhou, Mian; Zhou, Xiangshan; Zhang, Yuanxing; Cai, Menghao

2016-03-18

The alcohol oxidase 1 (AOX1) promoter (P AOX1) of Pichia pastoris is the most powerful and commonly used promoter for driving protein expression. However, mechanisms regulating its transcriptional activity are unclear. Here, we identified a Zn(II)2Cys6-type methanol-induced transcription factor 1 (Mit1) and elucidated its roles in regulating PAOX1 activity in response to glycerol and methanol. Mit1 regulated the expression of many genes involved in methanol utilization pathway, including AOX1, but did not participate in peroxisome proliferation and transportation of peroxisomal proteins during methanol metabolism. Structural analysis of Mit1 by performing domain deletions confirmed its specific and critical role in the strict repression of P AOX1 in glycerol medium. Importantly, Mit1, Mxr1, and Prm1, which positively regulated P AOX1 in response to methanol, were bound to P AOX1 at different sites and did not interact with each other. However, these factors cooperatively activated P AOX1 through a cascade. Mxr1 mainly functioned during carbon derepression, whereas Mit1 and Prm1 functioned during methanol induction, with Prm1 transmitting methanol signal to Mit1 by binding to the MIT1 promoter (P MIT1), thus increasingly expressing Mit1 and subsequently activating P AOX1. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Engineering and Physics Optimization of Breed and Burn Fast Reactor Systems; NUCLEAR ENERGY RESEARCH INITIATIVE (NERI) QUARTERLY PROGRESS REPORT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pavel Hejzlar, Peter Yarsky, Mike Driscoll, Dan Wachs, Kevan Weaver, Ken Czerwinski, Mike Pope, James Parry, Theron D. Marshall, Cliff B. Davis, Dustin Crawford, Thomas Hartmann, Pradip Saha; Hejzlar, Pavel; Yarsky, Peter

2005-01-31

This project is organized under four major tasks (each of which has two or more subtasks) with contributions among the three collaborating organizations (MIT, INEEL and ANL-West): Task A: Core Physics and Fuel Cycle; Task B: Core Thermal Hydraulics; Task C: Plant Design; Task D: Fuel Design The lead PI, Michael J. Driscoll, has consolidated and summarized the technical progress submissions provided by the contributing investigators from all sites, under the above principal task headings.

Design of a Non-Contact Vibration Measurement and Analysis System for Electronic Board Testing

DTIC Science & Technology

2004-06-01

United States Air Force Academy, 2002 SUBMITTED TO THE DEPARTMENT OF MECHANICAL ENGINEERING IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF...me with my master’s work. First, I would like to thank the Air Force and Draper Laboratory for the opportunity to complete my master’s degree at MIT...know that you are always welcome wherever the Air Force takes me. I would like to thank my family for helping me fulfill my life long dream of attending

The SME (Structure-Mapping Engine) User’s Manual (SME Version 2E)

DTIC Science & Technology

1988-12-30

It is prior to this step that one might want to think about wether to modify any system parameters (e.g., print the match hypotheses, print only the...Wshington, DC 20390 Department of Psychology Carnegie-Mellon University Dr. Judith Orsanu Schenley Park Dr. Harold P. O’Neil, Jr. Basic Research Office...Pinker Baltimore, MD 21201 Department of Psychology ElO-018 Dr. Judith W. Segal MIT Dr. J. Wesley Regian OERI Cambridge, MA 02139 AFHRL/IDI 556 New

Image Understanding: Proceedings of a Workshop (15th) Held at New Orleans, Louisiana on 3-4 October 1984

DTIC Science & Technology

1984-10-01

functions", Numer . Math., Engineering , Massachusetts Institute of Technology, 1980. (see 10, 177-183, 1967. also MIT Al Lab Technical Report 597, 1980...and steady growth. We have augmented our hardware and distance. In related work, we have explored the use of software base (Vax plus Grinnel, running...capabilities will be the body of software currently ac- 8. COMPUTING ENVIRONMENT FOR cumulated in the testbed and other programs now being devel- IU

Insight into the adsorption profiles of the Saprolegnia monoica chitin synthase MIT domain on POPA and POPC membranes by molecular dynamics simulation studies.

PubMed

Kuang, Guanglin; Liang, Lijun; Brown, Christian; Wang, Qi; Bulone, Vincent; Tu, Yaoquan

2016-02-21

The critical role of chitin synthases in oomycete hyphal tip growth has been established. A microtubule interacting and trafficking (MIT) domain was discovered in the chitin synthases of the oomycete model organism, Saprolegnia monoica. MIT domains have been identified in diverse proteins and may play a role in intracellular trafficking. The structure of the Saprolegnia monoica chitin synthase 1 (SmChs1) MIT domain has been recently determined by our group. However, although our in vitro assay identified increased strength in interactions between the MIT domain and phosphatidic acid (PA) relative to other phospholipids including phosphatidylcholine (PC), the mechanism used by the MIT domain remains unknown. In this work, the adsorption behavior of the SmChs1 MIT domain on POPA and POPC membranes was systematically investigated by molecular dynamics simulations. Our results indicate that the MIT domain can adsorb onto the tested membranes in varying orientations. Interestingly, due to the specific interactions between MIT residues and lipid molecules, the binding affinity to the POPA membrane is much higher than that to the POPC membrane. A binding hotspot, which is critical for the adsorption of the MIT domain onto the POPA membrane, was also identified. The lower binding affinity to the POPC membrane can be attributed to the self-saturated membrane surface, which is unfavorable for hydrogen-bond and electrostatic interactions. The present study provides insight into the adsorption profile of SmChs1 and additionally has the potential to improve our understanding of other proteins containing MIT domains.

Deletion of PdMit1, a homolog of yeast Csg1, affects growth and Ca(2+) sensitivity of the fungus Penicillium digitatum, but does not alter virulence.

PubMed

Zhu, Congyi; Wang, Weili; Wang, Mingshuang; Ruan, Ruoxin; Sun, Xuepeng; He, Meixian; Mao, Cungui; Li, Hongye

2015-04-01

GDP-mannose:inositol-phosphorylceramide (MIPC) and its derivatives are important for Ca(2+) sensitization of Saccharomyces cerevisiae and for the virulence of Candida albicans, but its role in the virulence of plant fungal pathogens remains unclear. In this study, we report the identification and functional characterization of PdMit1, the gene encoding MIPC synthase in Penicillium digitatum, one of the most important pathogens of postharvest citrus fruits. To understand the function of PdMit1, a PdMit1 deletion mutant was generated. Compared to its wild-type control, the PdMit1 deletion mutant exhibited slow radial growth, decreased conidia production and delayed conidial germination, suggesting that PdMit1 is important for the growth of mycelium, sporulation and conidial germination. The PdMit1 deletion mutant also showed hypersensitivity to Ca(2+). Treatment with 250 mmol/l Ca(2+) induced vacuole fusion in the wild-type strain, but not in the PdMit1 deletion mutant. Treatment with 250mmol/lCaCl2 upregulated three Ca(2+)-ATPase genes in the wild-type strain, and this was significantly inhibited in the PdMit1 deletion mutant. These results suggest that PdMit1 may have a role in regulating vacuole fusion and expression of Ca(2+)-ATPase genes by controlling biosynthesis of MIPC, and thereby imparts P. digitatum Ca(2+) tolerance. However, we found that PdMit1 is dispensable for virulence of P. digitatum. Copyright © 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

DDN (Defense Data Network) Protocol Handbook. Volume 3. Supplement

DTIC Science & Technology

1985-12-01

the physical configuration which results from this arrangement, Michael Padlipsky has described this as the " milking machine" approach to computer...NEIRJS-3 74 NETRJS-4 75 77 79 FINGER 81 HOSTS2-NS 83 MIT-ML-DEV 85 MIT-ML-DEV 87 89 SU-MIT-TG 91 MIT-DOV 93 DCP 95 SUPDUP 97 SWIFT- RVF ...PUP QUOTE RDP RJE RLP RTELNET RVD SAT-EXPAK SAT-MON SFTT? SMTP ST SU-MIT-TG SUNRPC SUPDUP SUR-MEAS SWIFT- RVF TACACS-DS TACNEWS

NASA Chief Technologist on Panel at Massachusetts Institute of Technology

NASA Image and Video Library

2018-02-15

During MIT's "Better MIT Innovation Week 2018," a group of experts discussed innovation as a critical component to and professional accomplishment. From left: Rebecca Chui, founder, RootsStudio; Reinaldo Normand, entrepreneur in residence, MIT; Douglas Terrier, NASA chief technologist; Linda Foster, chief technologist, Lockheed Martin. (Photo: Damian Barabonkov/MIT Technique)

MIT: Shaping the Future.

ERIC Educational Resources Information Center

Manning, Kenneth R., Ed.

This book provides 16 essays by faculty and staff of the Massachusetts Institute of Technology (MIT) concerning what MIT is like today and offering a guide to its possible future. Emphasis is placed on local, national, and global issues, providing a current sampling of the state of concerns and opinions around MIT. Topics include the question of…

Description of the Main Ionospheric Trough by the SM-MIT Model. European Longitudinal Sector

NASA Astrophysics Data System (ADS)

Leshchinskaya, T. Yu.; Pustovalova, L. V.

2018-05-01

Due to the selection of exsisting ionospheric models for incorporation into the created System of Ionospheric Monotoring and Prediction of the Russian Federation, the model of the main ionospheric trough (SM-MIT) is tested with the data from ground-based ionospheric observations in the European longitudinal sector. It is shown that the SM-MIT model does not give an increase in accuracy in comparison to the foF2 monthly median upon a description of the equatorial wall of the MIT. The model describes the foF2 values in the MIT minimum with higher accuracy than the foF2 monthly median or the median IRI model; however, at the same time, the deviations of the model foF2 values from the observed values are high enough: 20-30%. In the MIT minimum, the decrease in the model foF2 values relative to the median values is on average only 10%, which is substantially less than the observed depth of MIT in the evening sector. The verification results have shown that the available SM-MIT model must be completed for practical use.

Evaluation of the MIT RMID 1000 system for the identification of Listeria species.

PubMed

Ricardi, John; Haavig, David; Cruz, Lasaunta; Paoli, George; Gehring, Andrew

2010-01-01

The Micro Imaging Technology (MIT) 1000 Rapid Microbial Identification (RMID) System is a device that uses the principles of light scattering coupled with proprietary algorithms to identify bacteria after being cultured and placed in a vial of filtered water. This specific method is for pure culture identification of Listeria spp. A total of 81 microorganisms (55 isolates) were tested by the MIT 1000 System, of which 25 were Listeria spp. and 30 a variety of other bacterial species. In addition, a total of 406 tests over seven different ruggedness parameters were tested by the MIT 1000 System to determine its flexibility to the specifications stated in the MIT 1000 System User Guide in areas where they might be deviated by a user to shorten the test cycle. Overall, MIT concluded that the MIT 1000 System had an accuracy performance that should certify this Performance Test Method for the identification of Listeria spp. This report discusses the tests performed, results achieved, and conclusions, along with several reference documents to enable a higher understanding of the technology used by the MIT 1000 System.

First-order metal-insulator transition not accompanied by the structural phase transition observed in VO2-based devices

NASA Astrophysics Data System (ADS)

Kim, Hyun-Tak; Chae, Byung-Gyu; Kim, Bong-Jun; Lee, Yong-Wook; Yun, Sun-Jin; Kang, Kwang-Yong

2006-03-01

An abrupt first-order metal-insulator transition (MIT) is observed during the application of a switching pulse voltage to VO2-based two-terminal devices. When the abrupt MIT occurs, the structural phase transition (SPT) is investigated by a micro- Raman spectroscopy and a micro-XRD. The result shows that the MIT is not accompanied with the structural phase transition (SPT); the abrupt MIT is prior to the SPT. Moreover, any switching pulse over a threshold voltage of 7.1 V for the MIT enabled the device material to transform efficiently from an insulator to a metal. The measured delay time from the source switching pulse to an induced MIT pulse is an order of 20 nsec which is much less than a delay time of about one msec deduced by thermal model. This indicates that the first-order MIT does not occur due to thermal. We think this MIT is the Mott transition. (Reference: New J. Phys. 6 (1994) 52 (www.njp.org), Appl. Phys. Lett. 86 (2005) 242101, Physica B 369 (2005. December) xxxx)

Creating Catalytic Collaborations between Theater Artists, Scientists, and Research Institutions

NASA Astrophysics Data System (ADS)

Wise, Debra

2012-02-01

Catalyst Collaborative@MIT (CC@MIT) is a collaboration between MIT and Underground Railway Theater (URT), a company with 30 years experience creating theater through interdisciplinary inquiry and engaging community. CC@MIT is dedicated to creating and presenting plays that deepen public understanding about science, while simultaneously providing artistic and emotional experiences not available in other forms of dialogue about science. CC@MIT engages audiences in thinking about themes in science of social and ethical concern; provides insight into the culture of science and the impact of that culture on society; and examines the human condition through the lens of science that intersects our lives and the lives of scientists. Original productions range from Einstein's Dreams to From Orchids to Octopi -- an evolutionary love story; classics re-framed include The Life of Galileo and Breaking the Code (about Alan Turing). CC@MIT commissions playwrights and scientists to create plays; engages audiences with scientists; performs at MIT and a professional venue near the campus; collaborates with the Cambridge Science Festival and MIT Museum; engages MIT students, as well as youth and children. Artistic Director Debra Wise will address how the collaboration developed, what opportunities are provided by collaborations between theaters and scientific research institutions, and lessons learned of value to the field.

Mit1 Transcription Factor Mediates Methanol Signaling and Regulates the Alcohol Oxidase 1 (AOX1) Promoter in Pichia pastoris*

PubMed Central

Wang, Xiaolong; Wang, Qi; Wang, Jinjia; Bai, Peng; Shi, Lei; Shen, Wei; Zhou, Mian; Zhou, Xiangshan; Zhang, Yuanxing; Cai, Menghao

2016-01-01

The alcohol oxidase 1 (AOX1) promoter (PAOX1) of Pichia pastoris is the most powerful and commonly used promoter for driving protein expression. However, mechanisms regulating its transcriptional activity are unclear. Here, we identified a Zn(II)2Cys6-type methanol-induced transcription factor 1 (Mit1) and elucidated its roles in regulating PAOX1 activity in response to glycerol and methanol. Mit1 regulated the expression of many genes involved in methanol utilization pathway, including AOX1, but did not participate in peroxisome proliferation and transportation of peroxisomal proteins during methanol metabolism. Structural analysis of Mit1 by performing domain deletions confirmed its specific and critical role in the strict repression of PAOX1 in glycerol medium. Importantly, Mit1, Mxr1, and Prm1, which positively regulated PAOX1 in response to methanol, were bound to PAOX1 at different sites and did not interact with each other. However, these factors cooperatively activated PAOX1 through a cascade. Mxr1 mainly functioned during carbon derepression, whereas Mit1 and Prm1 functioned during methanol induction, with Prm1 transmitting methanol signal to Mit1 by binding to the MIT1 promoter (PMIT1), thus increasingly expressing Mit1 and subsequently activating PAOX1. PMID:26828066

The Efficacy and Timing of Melodic Intonation Therapy in Subacute Aphasia.

PubMed

van der Meulen, Ineke; van de Sandt-Koenderman, W Mieke E; Heijenbrok-Kal, Majanka H; Visch-Brink, Evy G; Ribbers, Gerard M

2014-07-01

Background Little is known about the efficacy of language production treatment in subacute severe nonfluent aphasia. Although Melodic Intonation Therapy (MIT) is a language production treatment for this disorder, until now MIT effect studies have focused on chronic aphasia. Purpose This study examines whether language production treatment with MIT is effective in subacute severe nonfluent aphasia. Methods A multicenter, randomized controlled trial was conducted in a waiting-list control design: patients were randomly allocated to the experimental group (MIT) or the control group (control intervention followed by delayed MIT). In both groups, therapy started at 2 to 3 months poststroke and was given intensively (5 h/wk) during 6 weeks. In a second therapy period, the control group received 6 weeks of intensive MIT. The experimental group resumed their regular treatment. Assessment was done at baseline (T1), after the first intervention period (T2), and after the second intervention period (T3). Efficacy was evaluated at T2. The impact of delaying MIT on therapy outcome was also examined. Results A total of 27 participants were included: n = 16 in the experimental group and n = 11 in the control group. A significant effect in favor of MIT on language repetition was observed for trained items, with mixed results for untrained items. After MIT there was a significant improvement in verbal communication but not after the control intervention. Finally, delaying MIT was related to less improvement in the repetition of trained material. Conclusions In these patients with subacute severe nonfluent aphasia, language production treatment with MIT was effective. Earlier treatment may lead to greater improvement. © The Author(s) 2014.

LOW-ENGINE-FRICTION TECHNOLOGY FOR ADVANCED NATURAL-GAS RECIPROCATING ENGINES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Victor W. Wong; Tian Tian; Grant Smedley

2003-08-28

This program aims at improving the efficiency of advanced natural-gas reciprocating engines (ANGRE) by reducing piston/ring assembly friction without major adverse effects on engine performance, such as increased oil consumption and emissions. A detailed set of piston/ring dynamic and friction models have been developed and applied that illustrated the fundamental relationships between design parameters and friction losses. Various low-friction strategies and concepts have been explored, and engine experiments will validate these concepts. An iterative process of experimentation, simulation and analysis, will be followed with the goal of demonstrating a complete optimized low-friction engine system. As planned, MIT has developed guidelinesmore » for an initial set of low-friction piston-ring-pack designs. Current recommendations focus on subtle top-piston-ring and oil-control-ring characteristics. A full-scale Waukesha F18 engine has been installed at Colorado State University and testing of the baseline configuration is in progress. Components for the first design iteration are being procured. Subsequent work includes examining the friction and engine performance data and extending the analyses to other areas to evaluate opportunities for further friction improvement and the impact on oil consumption/emission and wear, towards demonstrating an optimized reduced-friction engine system.« less

High-resolution linkage map in the proximity of the host resistance locus Cmv1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Depatie, C.; Muise, E.; Gros, P.

1997-01-15

The mouse chromosome 6 locus Cmv1 controls replication of mouse Cytomegalovirus (MCMV) in the spleen of the infected host. In our effort to clone Cmv1, we have constructed a high-resolution genetic linkage map in the proximity of the gene. For this, a total of 45 DNA markers corresponding to either cloned genes or microsatellites were mapped within a 7.9-cM interval overlapping the Cmv1 region. We have followed the cosegregation of these markers with respect to Cmv1 in a total of 2248 backcross mice from a preexisting interspecific backcross panel of 281 (Mus spretus X C57BL/6J)F1 X C57BL/6J and 2 novelmore » panels of 989 (A/J X C57BL6)F1 X A/J and 978 (BALB/c X C57BL/6J)F1 X BALB/c segregating Cmv1. Combined pedigree analysis allowed us to determine the following gene order and intergene distances (in cM) on the distal region of mouse chromosome 6: D6Mit216-(1.9)-D6Mit336-(2.2)-D6Mit218-(1.0)-D6Mit52-(0.5)-D6Mit194-(0.2)-Nkrp1/D6Mit61/135/257/289/338-(0.4)-Cmv1/Ly49A/D6Mit370-(0.3)-Prp/Kap/D6Mit13/111/219-(0.3)-Tel/D6Mit374/290/220/196/195/110-(1.1)-D6Mit25. Therefore, the minimal genetic interval for Cmv1 of 0.7 cM is defined by 13 tightly linked markers including 2 markers, Ly49A and D6Mit370, that did not show recombination with Cmv1 in 1967 meioses analyzed; the proximal limit of the Cmv1 domain was defined by 8 crossovers between Nkrp1/D6Mit61/135/257/289/338 and Cmv1/Ly49A/D6Mit370, and the distal limit was defined by 5 crossovers between Cmv1/Ly49A/D6Mit370 and Prp/Kap/D6Mit13/111/219. This work demonstrates tight linkage between Cmv1 and genes from the natural killer complex (NKC), such as Nkrp1 and Ly49A suggesting that Cmv1 may represent an NK cell recognition structure encoded in the NKC region. 54 refs., 4 figs., 2 tabs.« less

NASA Science Review of Next Planet-Hunting Mission Launch

NASA Image and Video Library

2018-04-15

NASA and science investigators from MIT participate in a science briefing for the agency's Transiting Exoplanet Survey Satellite (TESS) in the Press Site auditorium at Kennedy Space Center in Florida. Padi Boyd, TESS Guest Investigator Program lead, NASA’s Goddard Space Flight Center, answered questions during the briefing. TESS is the next step in the search for planets outside of our solar system. The mission will find exoplanets that periodically block part of the light from their host stars, events called transits. The satellite will survey the nearest and brightest stars for two years to search for transiting exoplanets. TESS will launch on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station no earlier than 6:32 p.m. EDT on Monday, April 16.

NASA Science Review of Next Planet-Hunting Mission Launch

NASA Image and Video Library

2018-04-15

NASA and science investigators from MIT participate in a science briefing for the agency's Transiting Exoplanet Survey Satellite (TESS) in the Press Site auditorium at Kennedy Space Center in Florida. Stephen Rinehart, TESS Project scientist, NASA’s Goddard Space Flight Center, answered questions during the briefing. TESS is the next step in the search for planets outside of our solar system. The mission will find exoplanets that periodically block part of the light from their host stars, events called transits. The satellite will survey the nearest and brightest stars for two years to search for transiting exoplanets. TESS will launch on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station no earlier than 6:32 p.m. EDT on Monday, April 16.

Intra-Engine Trace Species Chemistry

NASA Technical Reports Server (NTRS)

Waitz, Ian A.; Lukachko, S. P.; Chobot, A.; Miake-Lye, R. C.; Brown, R.

2002-01-01

Prompted by the needs of downstream plume-wake models, the Massachusetts Institute of Technology (MIT) and Aerodyne Research Incorporated (ART) initiated a collaborative effort, with funding from the NASA AEAP, to develop tools that would assist in understanding the fundamental drivers of chemical change within the intra-engine exhaust flow path. Efforts have been focused on the development of a modeling methodology that can adequately investigate the complex intra-engine environment. Over the history of this project, our research has increasingly pointed to the intra-engine environment as a possible site for important trace chemical activity. Modeling studies we initiated for the turbine and exhaust nozzle have contributed several important capabilities to the atmospheric effects of aviation assessment. These include a more complete understanding of aerosol precursor production, improved initial conditions for plume-wake modeling studies, and a more comprehensive analysis of ground-based test cell and in-flight exhaust measurement data. In addition, establishing a physical understanding of important flow and chemical processes through computational investigations may eventually assist in the design of engines to reduce undesirable species.

Goddard's Astrophysics Science Divsion Annual Report 2014

NASA Technical Reports Server (NTRS)

Weaver, Kimberly (Editor); Reddy, Francis (Editor); Tyler, Pat (Editor)

2015-01-01

The Astrophysics Science Division (ASD, Code 660) is one of the world's largest and most diverse astronomical organizations. Space flight missions are conceived, built and launched to observe the entire range of the electromagnetic spectrum, from gamma rays to centimeter waves. In addition, experiments are flown to gather data on high-energy cosmic rays, and plans are being made to detect gravitational radiation from space-borne missions. To enable these missions, we have vigorous programs of instrument and detector development. Division scientists also carry out preparatory theoretical work and subsequent data analysis and modeling. In addition to space flight missions, we have a vibrant suborbital program with numerous sounding rocket and balloon payloads in development or operation. The ASD is organized into five labs: the Astroparticle Physics Lab, the X-ray Astrophysics Lab, the Gravitational Astrophysics Lab, the Observational Cosmology Lab, and the Exoplanets and Stellar Astrophysics Lab. The High Energy Astrophysics Science Archive Research Center (HEASARC) is an Office at the Division level. Approximately 400 scientists and engineers work in ASD. Of these, 80 are civil servant scientists, while the rest are resident university-based scientists, contractors, postdoctoral fellows, graduate students, and administrative staff. We currently operate the Swift Explorer mission and the Fermi Gamma-ray Space Telescope. In addition, we provide data archiving and operational support for the XMM mission (jointly with ESA) and the Suzaku mission (with JAXA). We are also a partner with Caltech on the NuSTAR mission. The Hubble Space Telescope Project is headquartered at Goddard, and ASD provides Project Scientists to oversee operations at the Space Telescope Science Institute. Projects in development include the Neutron Interior Composition Explorer (NICER) mission, an X-ray timing experiment for the International Space Station; the Transiting Exoplanet Sky Survey (TESS) Explorer mission, in collaboration with MIT (Ricker, PI); the Soft X-ray Spectrometer (SXS) for the Astro-H mission in collaboration with JAXA, and the James Webb Space Telescope (JWST). The Wide-Field Infrared Survey Telescope (WFIRST), the highest ranked mission in the 2010 decadal survey, is in a pre-phase A study, and we are supplying study scientists for that mission.

OpenCourseWare Resources for Advanced High School Study

ERIC Educational Resources Information Center

Carson, Steve

2008-01-01

In 2000, the Massachusetts Institute of Technology (MIT) faculty first proposed putting the course materials from all 1,800 MIT classes online, free of charge. The idea behind MIT OpenCourseWare (OCW) was to use the Internet for more than just distance learning. When MIT began placing the course materials online in 2002 and 2003, the audience…

Wrestling with Pedagogical Change: The TEAL Initiative at MIT

ERIC Educational Resources Information Center

Breslow, Lori

2010-01-01

In the late 1990s, the physics department at the Massachusetts Institute of Technology (MIT) had a problem. The department was responsible for teaching the two required physics courses that are part of the General Institute Requirements (GIRs), MIT's core curriculum--Physics I (mechanics, or in MIT parlance, 8.01) and Physics II (electricity and…

A Mathematical Theory of Command and Control Structures.

DTIC Science & Technology

1984-08-30

minimize the functional J over the space of all linear maps,then (a) 6J ( HKL l 0)n 0 0 6JKi+Li (HK’L K i +Li) =0 .61H (H,K,L, )= 0 13 for all i=l,...N, and...Castanon, G. C. Verghese, A. S. Willsky, "A Scaterring Framework for Decentralized Estimation Problems," MIT/LIDS paper 1075 , March 1981, Submitted to

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vahala, G.; Tracy, E.

During the past year, the authors have concentrated on (1) divertor physics, (2) thermo-lattice Boltzmann (TLBE) approach to turbulence, and (3) phase space techniques in gyro-resonance problems in collaboration with Dieter Sigmar (MIT), Sergei Krasheninnikov (MIT), Linda Vahala (ODU), Joseph Morrison (AS and M/NASA-Langley), Pavol Pavlo and Josef Preinhaelter (institute of Plasma Physics, Czech Academy of Sciences) and Allan Kaufman (LBL/U.C.Berkeley). Using a 2-equation compressible closure model with a 2D mean flow, the authors are investigating the effects of 3D neutral turbulence on reducing the heat load to the divertor plate by various toroidal cavity geometries. These studies are beingmore » extended to examine 3D mean flows. Thermal Lattice Boltzmann (TLBE) methods are being investigated to handle 3D turbulent flows in nontrivial geometries. It is planned to couple the TLBE collisional regime to the weakly collisional regime and so be able to tackle divertor physics. In the application of phase space techniques to minority-ion RF heating, resonance heating is treated as a multi-stage process. A generalization of the Case-van Kampen analysis is presented for multi-dimensional non-uniform plasmas. Effects such as particle trapping and the ray propagation dynamics in tokamak geometry can now be handled using Weyl calculus.« less

Combined strain and composition-induced effects in the metal-insulator transition of epitaxial VO2 films

NASA Astrophysics Data System (ADS)

Théry, V.; Boulle, A.; Crunteanu, A.; Orlianges, J. C.

2017-12-01

The role of epitaxial strain, thermal strain, and bulk (strain-free) lattice parameters in the metal-insulator transition (MIT) and the structural phase transition (SPT) of VO2 is investigated for the case of epitaxial films grown on (001)-oriented TiO2 substrates. Temperature-resolved X-ray reciprocal space mapping has been used to determine the absolute state of strain as well as the bulk lattice parameters of VO2 at 100 °C. For the thinnest film (15 nm), the state of strain is dominated by the film/substrate lattice mismatch yielding an in-plane tensile strain which, in turn, shifts both the MIT and the SPT towards lower temperatures. Conversely, for the thickest film (100 nm), the epitaxial strain is relaxed, so that the state of strain is dominated by the VO2/TiO2 thermal expansion mismatch which is responsible for a compressive in-plane strain. In all cases, a swelling of the strain-free VO2 unit-cell is observed which indicates the presence of interfacial oxygen vacancies and/or Ti diffusion into the VO2 films. The presence of oxygen vacancies stabilizes the metallic rutile phase and counterbalances the action of thermal strain on the MIT and the SPT and degrades the electric properties for the thinnest film. For the thickest film, the resistivity ratio is 6.4 × 104.

Alternate Realities

NASA Astrophysics Data System (ADS)

Jones, Robert

2010-02-01

Two identical learners, observing different example input, or the same examples, but in different order, can form different categories and so judge newer/later input differently. (Machine Learning, T. Mitchell, McGraw Hill, 1997 and Asa H., R. Jones, Trans. Kansas Acad. Sci., vol 109, # 3/4, pg 159, 2006) It seems certain that each of us experiences a somewhat different reality, the question is just how widely these realities can vary one from another. Perhaps 4% of people exhibit synesthesia, perceiving letters or numbers as colored, numbers and dates as having personalities or occupying locations in space. (Synesthesia, R. Cytowic, MIT Press, 2002) The Sapir- Whorf hypothesis claims that a speakers language influences his category structure and the way he thinks. (Language, thought, and reality, B. Whorf, MIT Press, 1956) Those who are skillful at mathematics may know an additional language and be able to think thoughts that the layman can not. The philosophers Plato and Descartes claimed to have had, at certain moments in their lives, a new view of the world, its basic constituents, and its rules which were totally different from our conventional view of reality. (Reflections on Kurt Godel, H. Wang, MIT Press, 1987, pg. 46) Fairly large scale differences are experienced by those who believe in (make use of) concepts like spirit(s), soul(s), god(s), life after death, platonism or Everett's many worlds interpretation of quantum mechanics (The Physics of Immortality, F. Tipler, Doubleday, 1994, pg. 176) )

Determinants of complete resection of thymoma by minimally invasive and open thymectomy: analysis of an international registry

PubMed Central

Burt, Bryan M.; Yao, Xiaopan; Shrager, Joseph; Antonicelli, Alberto; Padda, Sukhmani; Reiss, Jonathan; Wakelee, Heather; Su, Stacey; Huang, James; Scott, Walter

2017-01-01

INTRODUCTION Minimally invasive thymectomy (MIT) is a surgical approach to thymectomy that has more favorable short-term outcomes than open thymectomy (OT) for myasthenia gravis. When performed for thymoma, the oncologic outcomes of MIT have not been rigorously evaluated. We analyzed determinants of complete (R0) resection among patients undergoing MIT and open thymectomy in a large international database. METHODS The retrospective database of the International Thymic Malignancy Interest Group (ITMIG) was queried. Chi-Square and Wilcoxon rank-sum tests, multivariate logistic regression models, and propensity matching were performed. RESULTS A total of 2514 patients underwent thymectomy for thymoma between 1997 and 2012. 2053 (82%) patients underwent OT, 461 (18%) patients underwent MIT, and the use of MIT increased significantly in recent years. The rate of R0 resection among patients undergoing OT was 86%, and among those undergoing MIT was 94%, respectively (p<0.0001). In propensity matched MIT and OT groups (n=266 each group), however, the rate of R0 resection did not differ significantly (MIT 96%, OT 96%, p=0.7). Multivariate analyses were performed to identify determinants of complete resection. Factors independently associated with R0 resection were geographical region, later time period, less advanced Masaoka stage, total thymectomy, and the absence of radiotherapy. Surgical approach, whether minimally invasive or open, was not associated with completeness of resection. CONCLUSIONS The use of MIT for resection of thymoma is increasing substantially over time, and MIT can achieve similar rates of R0 resection for thymoma as OT. PMID:27566187

Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome

PubMed Central

McCarthy, Cameron G.; Szasz, Theodora; Goulopoulou, Styliani; Webb, R. Clinton

2015-01-01

Fifty percent of trauma patients who present sepsis-like syndrome do not have bacterial infections. This condition is known as systemic inflammatory response syndrome (SIRS). A unifying factor of SIRS and sepsis is cardiovascular collapse. Trauma and severe blood loss cause the release of endogenous molecules known as damage-associated molecular patterns. Mitochondrial N-formyl peptides (F-MIT) are damage-associated molecular patterns that share similarities with bacterial N-formylated peptides and are potent immune system activators. The goal of this study was to investigate whether F-MIT trigger SIRS, including hypotension and vascular collapse via formyl peptide receptor (FPR) activation. We evaluated cardiovascular parameters in Wistar rats treated with FPR or histamine receptor antagonists and inhibitors of the nitric oxide pathway before and after F-MIT infusion. F-MIT, but not nonformylated peptides or mitochondrial DNA, induced severe hypotension via FPR activation and nitric oxide and histamine release. Moreover, F-MIT infusion induced hyperthermia, blood clotting, and increased vascular permeability. To evaluate the role of leukocytes in F-MIT-induced hypotension, neutrophil, basophil, or mast cells were depleted. Depletion of basophils, but not neutrophils or mast cells, abolished F-MIT-induced hypotension. Rats that underwent hemorrhagic shock increased plasma levels of mitochondrial formylated proteins associated with lung damage and antagonism of FPR ameliorated hemorrhagic shock-induced lung injury. Finally, F-MIT induced vasodilatation in isolated resistance arteries via FPR activation; however, F-MIT impaired endothelium-dependent relaxation in the presence of blood. These data suggest that F-MIT may be the link among trauma, SIRS, and cardiovascular collapse. PMID:25637548

Wirksamkeit und Sicherheit von Fumarsäureestern in Kombination mit Phototherapie bei Patienten mit moderater bis schwerer Plaque-Psoriasis (FAST).

PubMed

Weisenseel, Peter; Reich, Kristian; Griemberg, Wiebke; Merten, Katharina; Gröschel, Christine; Gomez, Natalie Nunez; Taipale, Kirsi; Bräu, Beate; Zschocke, Ina

2017-02-01

Die Behandlung von Psoriasis-Patienten mit einer Kombination aus Fumarsäureestern (FSE, Fumaderm ® ) und Phototherapie (UV) ist verbreitet, wurde aber im Rahmen von Studien wenig untersucht. Bisher liegen lediglich Daten aus einer kleinen Pilotstudie vor. Intention dieser Studie war, eine FSE/UV-Kombinationsbehandlung an einem größeren Patientenkollektiv mit mittelschwerer bis schwerer Psoriasis zu untersuchen. In dieser prospektiven, multizentrischen, nichtinterventionellen Studie wurden Daten von Patienten mit FSE/UV-Kombinationstherapie hinsichtlich der Wirksamkeit (PGA' PASI, DLQI, EQ-5D), Sicherheit und Dosierung über einen Zeitraum von zwölf Monaten erfasst und mit Daten einer retrospektiven Studie mit FSE-Monotherapie verglichen. Es wurden Daten von 363 Patienten ausgewertet. Unter der Kombinationstherapie verbesserten sich alle Wirksamkeitsparameter deutlich. Im Vergleich zur Monotherapie mit FSE konnte durch die Kombination mit UV ein schnellerer Wirkeintritt erzielt werden, wobei nach zwölf Monaten kein Unterschied in der Wirksamkeit bestand. Die Dauer und Art der Phototherapie zeigte keinen Einfluss auf die Wirksamkeitsparameter. Allgemein wurde die Kombinationstherapie gut vertragen. Unerwünschte Ereignisse wurden bei 7 % der Patienten berichtet. Die FSE/UV Kombinationstherapie zeigt eine gute Wirksamkeit und Verträglichkeit und kann zu einem schnelleren Wirkeintritt führen. Eine Kombinationstherapie erscheint vor allem in den ersten drei Monaten der FSE Behandlung sinnvoll. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Distinct Mechanisms of Recognizing Endosomal Sorting Complex Required for Transport III (ESCRT-III) Protein IST1 by Different Microtubule Interacting and Trafficking (MIT) Domains*

PubMed Central

Guo, Emily Z.; Xu, Zhaohui

2015-01-01

The endosomal sorting complex required for transport (ESCRT) machinery is responsible for membrane remodeling in a number of biological processes including multivesicular body biogenesis, cytokinesis, and enveloped virus budding. In mammalian cells, efficient abscission during cytokinesis requires proper function of the ESCRT-III protein IST1, which binds to the microtubule interacting and trafficking (MIT) domains of VPS4, LIP5, and Spartin via its C-terminal MIT-interacting motif (MIM). Here, we studied the molecular interactions between IST1 and the three MIT domain-containing proteins to understand the structural basis that governs pairwise MIT-MIM interaction. Crystal structures of the three molecular complexes revealed that IST1 binds to the MIT domains of VPS4, LIP5, and Spartin using two different mechanisms (MIM1 mode versus MIM3 mode). Structural comparison revealed that structural features in both MIT and MIM contribute to determine the specific binding mechanism. Within the IST1 MIM sequence, two phenylalanine residues were shown to be important in discriminating MIM1 versus MIM3 binding. These observations enabled us to deduce a preliminary binding code, which we applied to provide CHMP2A, a protein that normally only binds the MIT domain in the MIM1 mode, the additional ability to bind the MIT domain of Spartin in the MIM3 mode. PMID:25657007

[R]MIT Research Centre at Delft University of Technology: A Bridge between Research, Education, Society and Profession

ERIC Educational Resources Information Center

Zijlstra, Hielkje

2009-01-01

In 2006, we launched the [R]MIT Research Centre (Modification, Intervention Transformation) at the Faculty of Architecture at Delft University of Technology. [R]MIT was founded to respond to the need for an integrated, multi-disciplinary approach to the transformation of the built environment. [R]MIT aims to bring momentum to the renewal of…

Microgravity Investigation of Crew Reactions in 0-G (MICR0-G): Ground-Based Development Effort

NASA Technical Reports Server (NTRS)

Newman, Dava J.

2002-01-01

This report describes the technology development of an advanced load sensor ground-based prototype and details the preliminary tests in microgravity during parabolic flights. The research effort is entitled, the Microgravity Investigation and Crew Reactions in 0-G (MICR0-G), a ground-based research effort funded by the National Aeronautics and Space Administration (NASA). The MICR0-G project was a follow-on to the Enhanced Dynamic Load Sensors (EDLS) spaceflight experiment flown on the Russian Space Station Mir. The technology development of the advanced load sensor prototype has been carried out by the Massachusetts Institute of Technology (MIT), with collaboration from Politecnico di Milano University and the Italian Space Agency (ASI). The key hardware of the advanced sensor prototype is a set of two types of load sensors - a hand-hold and foot restraints - similar in appearance to the mobility aids found in the Space Shuttle orbiter to assist the crew in moving inside the spacecraft, but able to measure the applied forces and moments about the x-, y-, and z- axes. The aim of Chapter 1 is to give a brief overview of the report contents. The first section summarizes the previous research efforts on astronaut-induced loads in microgravity. The second section provides information on the MICR0-G research project and the technology development work conducted at MIT. Section 1.3 details the motivation for designing a new generation of load sensors and describes the main enhancements and contributions of the MICR0-G advanced load sensors system compared to the EDLS system. Finally, the last section presents the outline of the report.

NASA Medical Response to Human Spacecraft Accidents

NASA Technical Reports Server (NTRS)

Patlach, Robert

2011-01-01

This slide presentation reviews NASA's role in the response to spacecraft accidents that involve human fatalities or injuries. Particular attention is given to the work of the Mishap Investigation Team (MIT), the first response to the accidents and the interface to the accident investigation board. The MIT does not investigate the accident, but the objective of the MIT is to gather, guard, preserve and document the evidence. The primary medical objectives of the MIT is to receive, analyze, identify, and transport human remains, provide assistance in the recovery effort, and to provide family Casualty Coordinators with latest recovery information. The MIT while it does not determine the cause of the accident, it acts as the fact gathering arm of the Mishap Investigation Board (MIB), which when it is activated may chose to continue to use the MIT as its field investigation resource. The MIT membership and the specific responsibilities and tasks of the flight surgeon is reviewed. The current law establishing the process is also reviewed.

The rice mitochondrial iron transporter is essential for plant growth

PubMed Central

Bashir, Khurram; Ishimaru, Yasuhiro; Shimo, Hugo; Nagasaka, Seiji; Fujimoto, Masaru; Takanashi, Hideki; Tsutsumi, Nobuhiro; An, Gynheung; Nakanishi, Hiromi; Nishizawa, Naoko K.

2011-01-01

In plants, iron (Fe) is essential for mitochondrial electron transport, heme, and Fe-Sulphur (Fe-S) cluster synthesis; however, plant mitochondrial Fe transporters have not been identified. Here we show, identify and characterize the rice mitochondrial Fe transporter (MIT). Based on a transfer DNA library screen, we identified a rice line showing symptoms of Fe deficiency while accumulating high shoot levels of Fe. Homozygous knockout of MIT in this line resulted in a lethal phenotype. MIT localized to the mitochondria and complemented the growth of Δmrs3Δmrs4 yeast defective in mitochondrial Fe transport. The growth of MIT-knockdown (mit-2) plants was also significantly impaired despite abundant Fe accumulation. Further, the decrease in the activity of the mitochondrial and cytosolic Fe-S enzyme, aconitase, indicated that Fe-S cluster synthesis is affected in mit-2 plants. These results indicate that MIT is a mitochondrial Fe transporter essential for rice growth and development. PMID:21610725

Ultra-Rapid 2-D and 3-D Laser Microprinting of Proteins

NASA Astrophysics Data System (ADS)

Scott, Mark Andrew

When viewed under the microscope, biological tissues reveal an exquisite microarchitecture. These complex patterns arise during development, as cells interact with a multitude of chemical and mechanical cues in the surrounding extracellular matrix. Tissue engineers have sought for decades to repair or replace damaged tissue, often relying on porous scaffolds as an artificial extracellular matrix to support cell development. However, these grafts are unable to recapitulate the complexity of the in vivo environment, limiting our ability to regenerate functional tissue. Biomedical engineers have developed several methods for printing two- and three-dimensional patterns of proteins for studying and directing cell development. Of these methods, laser microprinting of proteins has shown the most promise for printing sub-cellular resolution gradients of cues, but the photochemistry remains too slow to enable large-scale applications for screening and therapeutics In this work, we demonstrate a novel high-speed photochemistry based on multi-photon photobleaching of fluorescein, and we build the fastest 2-D and 3-D laser microprinter for proteins to date. First, we show that multiphoton photobleaching of a deoxygenated solution of biotin-4-fluorescein onto a PEG monolayer with acrylate end-group can enable print speeds of almost 20 million pixels per second at 600 nanometer resolution. We discovered that the mechanism of fluorescein photobleaching evolves from a 2-photon to 3- and 4-photon regime at higher laser intensities, unlocking faster printing kinetics. Using this 2-D printing system, we develop a novel triangle-ratchet method for directing the polarization of single hippocampal neurons. This ability to determine which neurite becomes an axon, and which neuritis become dendrites is an essential step for developing defined in vitro neural networks. Next, we modify our multiphoton photobleaching system to print in three dimensions. For the first time, we demonstrate 3-D printing of full length proteins in collagen, fibrin and gelatin methacrylate scaffolds, as well as printing in agarose and agarose methacrylate scaffolds. We also present a novel method for 3-D printing collagen scaffolds at unprecedented speeds, up to 14layers per second, generating complex shapes in seconds with sub-micron resolution. Finally, we demonstrate that 3-D printing of scaffold architecture and protein cues inside the scaffold can be combined, for the first time enabling structures with complex sub-micron architectures and chemical cues for directing development. We believe that the ultra-rapid printing technology presented in this thesis will be a key enabler in the development of complex, artificially engineered tissues and organs. (Copies available exclusively from MIT Libraries, libraries.mit.edu/docs - docs mit.edu)

Preparation and modification of VO2 thin film on R-sapphire substrate by rapid thermal process

NASA Astrophysics Data System (ADS)

Zhu, Nai-Wei; Hu, Ming; Xia, Xiao-Xu; Wei, Xiao-Ying; Liang, Ji-Ran

2014-04-01

The VO2 thin film with high performance of metal-insulator transition (MIT) is prepared on R-sapphire substrate for the first time by magnetron sputtering with rapid thermal process (RTP). The electrical characteristic and THz transmittance of MIT in VO2 film are studied by four-point probe method and THz time domain spectrum (THz-TDS). X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and search engine marketing (SEM) are employed to analyze the crystalline structure, valence state, surface morphology of the film. Results indicate that the properties of VO2 film which is oxidized from the metal vanadium film in oxygen atmosphere are improved with a follow-up RTP modification in nitrogen atmosphere. The crystallization and components of VO2 film are improved and the film becomes compact and uniform. A better phase transition performance is shown that the resistance changes nearly 3 orders of magnitude with a 2-°C hysteresis width and the THz transmittances are reduced by 64% and 60% in thermal and optical excitation respectively.

Feasibility of remotely manipulated welding in space: A step in the development of novel joining technologies

NASA Technical Reports Server (NTRS)

Masubuchi, K.; Agapakis, J. E.; Debiccari, A.; Vonalt, C.

1985-01-01

A six month research program entitled Feasibility of Remotely Manipulated Welding in Space - A Step in the Development of Novel Joining Technologies is performed at the Massachusetts Institute of Technology for the Office of Space Science and Applications, NASA, under Contract No. NASW-3740. The work is performed as a part of the Innovative Utilization of the Space Station Program. The final report from M.I.T. was issued in September 1983. This paper presents a summary of the work performed under this contract. The objective of this research program is to initiate research for the development of packaged, remotely controlled welding systems for space construction and repair. The research effort includes the following tasks: (1) identification of probable joining tasks in space; (2) identification of required levels of automation in space welding tasks; (3) development of novel space welding concepts; (4) development of recommended future studies; and (5) preparation of the final report.

TESS SpaceX Fairing Halves Lift to Vertical; Payload Encapsulation

NASA Image and Video Library

2018-04-08

Technicians prepare NASA's Transiting Exoplanet Survey Satellite (TESS) for encapsulation in the SpaceX payload fairing inside the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

The Onsala Twin Telescope Project

NASA Astrophysics Data System (ADS)

Haas, R.

2013-08-01

This paper described the Onsala Twin Telescope project. The project aims at the construction of two new radio telescopes at the Onsala Space Observatory, following the VLBI2010 concept. The project starts in 2013 and is expected to be finalized within 4 years. Z% O. Rydbeck. Chalmers Tekniska Högskola, Göteborg, ISBN 91-7032-621-5, 407-823, 1991. B. Petrachenko, A. Niell, D. Behrend, B. Corey, J. Böhm, P. Charlot, A. Collioud, J. Gipson, R. Haas, Th. Hobiger, Y. Koyama, D. MacMillan, Z. Malkin, T. Nilsson, A. Pany, G. Tuccari, A. Whitney, and J. Wresnik. Design Aspects of the VLBI2010 System. NASA/TM-2009-214180, 58 pp., 2009. R. Haas, G. Elgered, J. Löfgren, T. Ning, and H.-G. Scherneck. Onsala Space Observatory - IVS Network Station. In K. D. Baver and D. Behrend, editors, International VLBI Service for Geodesy and Astrometry 2011 Annual Report, NASA/TP-2012-217505, 88-91, 2012. H.-G. Scherneck, G. Elgered, J. M. Johansson, and B. O. Rönnäng. Phys. Chem. Earth, Vol. 23, No. 7-8, 811-823, 1998. A. R. Whitney. Ph.D. thesis, Dept. of Electrical engineering, MIT Cambridge, MA., 1974. B. A. Harper, J. D. Kepert, and J. D. Ginger. Guidelines for converting between various wind averaging periods in tropical cyclone conditions. WMO/TD-No. 1555, 64 pp., 2010 (available at \\url{http://www.wmo.int/pages/prog/www/tcp/documents/WMO_TD_1555_en.pdf})

NASA Science Review of Next Planet-Hunting Mission Launch

NASA Image and Video Library

2018-04-15

NASA and science investigators from MIT participate in a science briefing for the agency's Transiting Exoplanet Survey Satellite (TESS) in the Press Site auditorium at Kennedy Space Center in Florida. Felicia Chou, NASA Communications, asks questions from online participants during the briefing. TESS is the next step in the search for planets outside of our solar system. The mission will find exoplanets that periodically block part of the light from their host stars, events called transits. The satellite will survey the nearest and brightest stars for two years to search for transiting exoplanets. TESS will launch on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station no earlier than 6:32 p.m. EDT on Monday, April 16.

NASA Science Review of Next Planet-Hunting Mission Launch

NASA Image and Video Library

2018-04-15

NASA and science investigators from MIT participate in a science briefing for the agency's Transiting Exoplanet Survey Satellite (TESS) in the Press Site auditorium at Kennedy Space Center in Florida. Claire Saravia, NASA Communications, moderated the briefing. TESS is the next step in the search for planets outside of our solar system. The mission will find exoplanets that periodically block part of the light from their host stars, events called transits. The satellite will survey the nearest and brightest stars for two years to search for transiting exoplanets. TESS will launch on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station no earlier than 6:32 p.m. EDT on Monday, April 16.

NASA Science Review of Next Planet-Hunting Mission Launch

NASA Image and Video Library

2018-04-15

NASA and science investigators from MIT participate in a science briefing for the agency's Transiting Exoplanet Survey Satellite (TESS) in the Press Site auditorium at Kennedy Space Center in Florida. Paul Hertz, Astrophysics Division director, NASA Headquarters, answered questions during the briefing. TESS is the next step in the search for planets outside of our solar system. The mission will find exoplanets that periodically block part of the light from their host stars, events called transits. The satellite will survey the nearest and brightest stars for two years to search for transiting exoplanets. TESS will launch on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station no earlier than 6:32 p.m. EDT on Monday, April 16.

Implementation of Satellite Formation Flight Algorithms Using SPHERES Aboard the International Space Station

NASA Technical Reports Server (NTRS)

Mandy, Christophe P.; Sakamoto, Hiraku; Saenz-Otero, Alvar; Miller, David W.

2007-01-01

The MIT's Space Systems Laboratory developed the Synchronized Position Hold Engage and Reorient Experimental Satellites (SPHERES) as a risk-tolerant spaceborne facility to develop and mature control, estimation, and autonomy algorithms for distributed satellite systems for applications such as satellite formation flight. Tests performed study interferometric mission-type formation flight maneuvers in deep space. These tests consist of having the satellites trace a coordinated trajectory under tight control that would allow simulated apertures to constructively interfere observed light and measure the resulting increase in angular resolution. This paper focuses on formation initialization (establishment of a formation using limited field of view relative sensors), formation coordination (synchronization of the different satellite s motion) and fuel-balancing among the different satellites.

Phylogenetic relationships of the Gomphales based on nuc-25S-rDNA, mit-12S-rDNA, and mit-atp6-DNA combined sequences

Treesearch

Admir J. Giachini; Kentaro Hosaka; Eduardo Nouhra; Joseph Spatafora; James M. Trappe

2010-01-01

Phylogenetic relationships among Geastrales, Gomphales, Hysterangiales, and Phallales were estimated via combined sequences: nuclear large subunit ribosomal DNA (nuc-25S-rDNA), mitochondrial small subunit ribosomal DNA (mit-12S-rDNA), and mitochondrial atp6 DNA (mit-atp6-DNA). Eighty-one taxa comprising 19 genera and 58 species...

Determinants of Complete Resection of Thymoma by Minimally Invasive and Open Thymectomy: Analysis of an International Registry.

PubMed

Burt, Bryan M; Yao, Xiaopan; Shrager, Joseph; Antonicelli, Alberto; Padda, Sukhmani; Reiss, Jonathan; Wakelee, Heather; Su, Stacey; Huang, James; Scott, Walter

2017-01-01

Minimally invasive thymectomy (MIT) is a surgical approach to thymectomy that has more favorable short-term outcomes for myasthenia gravis than open thymectomy (OT). The oncologic outcomes of MIT performed for thymoma have not been rigorously evaluated. We analyzed determinants of complete (R0) resection among patients undergoing MIT and OT in a large international database. The retrospective database of the International Thymic Malignancy Interest Group was queried. Chi-square and Wilcoxon rank sum tests, multivariate logistic regression models, and propensity matching were performed. A total of 2514 patients underwent thymectomy for thymoma between 1997 and 2012; 2053 of them (82%) underwent OT and 461 (18%) underwent MIT, with the use of MIT increasing significantly in recent years. The rate of R0 resection among patients undergoing OT was 86%, and among those undergoing MIT it was 94% (p < 0.0001). In propensity-matched MIT and OT groups (n = 266 in each group); however, the rate of R0 resection did not differ significantly (96% in both the MIT and OT groups, p = 0.7). Multivariate analyses were performed to identify determinants of R0 resection. Factors independently associated with R0 resection were geographical region, later time period, less advanced Masaoka stage, total thymectomy, and the absence of radiotherapy. Surgical approach, whether minimally invasive or open, was not associated with completeness of resection. The use of MIT for resection of thymoma has been increasing substantially over time, and MIT can achieve rates of R0 resection for thymoma similar to those achieved with OT. Copyright © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

Molecular mapping of the tubby (tub) mutation on mouse chromosome 7

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, W.K.; Goldberg-Berman, J.; Power-Kehoe, L.

1996-03-01

Using 180 F2 progeny of a C57BL6/J x CAST/Ei tub/+F1 intersubspecific intercross, a map of 28 molecular markers (including eight genes) on chromosome 7 surrounding the tub locus was generated. Using 33 obese F2 progeny, tub was localized approximately 50-52 cM distal to the centromere on mouse chromosome 7 in the interval defined proximally by hemoglobin beta (Hbb), D7Mit38, D7Mit217, D7Mit37, D7Mit96, and D7Mit33 and distally by D7Mit 98. Using 39 obese F2 progeny from a similar intersubspecific intercross, a telomeric boundary of the interval defining tub was defined by D7Mit53; the order centromere-Hbb/tub-D7Mit53/D7Mit328/D7Mit220-parathyroid hormone (Pth)-calcitonin (Calc)-zona pellucida 2 (2p2)more » was established. By combining the data from the two crosses, the most likely gene order on mouse chromosome 7 is centromere-Hbb-tub-Pth-Calc, thus making it likely that the human homolog of tub resides on 11p15, where the gene order HBB-PTH-CALC is conserved. Assignment of the human tubby homolog to 11p15 allows selection and development of polymorphic molecular markers that can be used to examine segregation of a human homolog of tubby in pedigrees segregating for obesity. The gene sulfonylurea receptor was eliminated as a candidate gene for tubby on the basis of its map position, approximately 3.1 {plus_minus} 3.1 cM centromeric of tyrosinase and approximately 14.9 {plus_minus} 4.8 cM centromeric of Hbb. 47 refs., 2 figs., 2 tabs.« less

Ankle muscle strength discriminates fallers from non-fallers

PubMed Central

Cattagni, Thomas; Scaglioni, Gil; Laroche, Davy; Van Hoecke, Jacques; Gremeaux, Vincent; Martin, Alain

2014-01-01

It is well known that center of pressure (CoP) displacement correlates negatively with the maximal isometric torque (MIT) of ankle muscles. This relationship has never been investigated in elderly fallers (EF). The purpose of this study was thus to analyze the relationship between the MIT of ankle muscles and CoP displacement in upright stance in a sample aged between 18 and 90 years old that included EF. The aim was to identify a threshold of torque below which balance is compromised. The MIT of Plantar flexors (PFs) and dorsal flexors (DFs) and CoP were measured in 90 volunteers: 21 healthy young adults (YA) (age: 24.1 ± 5.0), 12 healthy middle-aged adults (MAA) (age: 50.2 ± 4.5), 27 healthy elderly non-fallers (ENF) (age: 75.5 ± 7.0) and 30 EF (age: 78.8 ± 6.7). The MIT of PF and DF were summed to obtain the overall maximal ankle muscle strength. Body weight and height were used to normalize MIT (nMIT) and CoP (nCoP), respectively. nCoP correlated negatively with nMIT. 90% of EF generated an nMIT <3.1 N·m·kg−1, whereas 85% of non-fallers generated an nMIT >3.1 N·m·kg−1. The relationship between nMIT and nCoP implies that ankle muscle weakness contributes to increased postural instability and the risk of falling. We observed that below the threshold of 3.1 N·m·kg−1, postural stability was dramatically diminished and balance was compromised. Our results suggest that measuring ankle torque could be used in routine clinical practice to identify potential fallers. PMID:25566068

Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains.

PubMed

Guo, Emily Z; Xu, Zhaohui

2015-03-27

The endosomal sorting complex required for transport (ESCRT) machinery is responsible for membrane remodeling in a number of biological processes including multivesicular body biogenesis, cytokinesis, and enveloped virus budding. In mammalian cells, efficient abscission during cytokinesis requires proper function of the ESCRT-III protein IST1, which binds to the microtubule interacting and trafficking (MIT) domains of VPS4, LIP5, and Spartin via its C-terminal MIT-interacting motif (MIM). Here, we studied the molecular interactions between IST1 and the three MIT domain-containing proteins to understand the structural basis that governs pairwise MIT-MIM interaction. Crystal structures of the three molecular complexes revealed that IST1 binds to the MIT domains of VPS4, LIP5, and Spartin using two different mechanisms (MIM1 mode versus MIM3 mode). Structural comparison revealed that structural features in both MIT and MIM contribute to determine the specific binding mechanism. Within the IST1 MIM sequence, two phenylalanine residues were shown to be important in discriminating MIM1 versus MIM3 binding. These observations enabled us to deduce a preliminary binding code, which we applied to provide CHMP2A, a protein that normally only binds the MIT domain in the MIM1 mode, the additional ability to bind the MIT domain of Spartin in the MIM3 mode. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Distinct Mechanisms of Recognizing Endosomal Sorting Complex Required for Transport III (ESCRT-III) Protein IST1 by Different Microtubule Interacting and Trafficking (MIT) Domains

DOE PAGES

Guo, Emily Z.; Xu, Zhaohui

2015-02-05

The endosomal sorting complex required for transport (ESCRT) machinery is responsible for membrane remodeling in a number of biological processes including multivesicular body biogenesis, cytokinesis, and enveloped virus budding. In mammalian cells, efficient abscission during cytokinesis requires proper function of the ESCRT-III protein IST1, which binds to the microtubule interacting and trafficking (MIT) domains of VPS4, LIP5, and Spartin via its C-terminal MIT-interacting motif (MIM). In this paper, we studied the molecular interactions between IST1 and the three MIT domain-containing proteins to understand the structural basis that governs pairwise MIT-MIM interaction. Crystal structures of the three molecular complexes revealed thatmore » IST1 binds to the MIT domains of VPS4, LIP5, and Spartin using two different mechanisms (MIM1 mode versus MIM3 mode). Structural comparison revealed that structural features in both MIT and MIM contribute to determine the specific binding mechanism. Within the IST1 MIM sequence, two phenylalanine residues were shown to be important in discriminating MIM1 versus MIM3 binding. Finally, these observations enabled us to deduce a preliminary binding code, which we applied to provide CHMP2A, a protein that normally only binds the MIT domain in the MIM1 mode, the additional ability to bind the MIT domain of Spartin in the MIM3 mode.« less

Space civil engineering - A new discipline

NASA Technical Reports Server (NTRS)

Sadeh, Willy Z.; Criswell, Marvin E.

1991-01-01

Space Civil Engineering is an emerging engineering discipline that focuses on extending and expanding the Civil Engineering know-how and practice to the development and maintenance of infrastructure on celestial bodies. Space Civil Engineering is presently being developed as a new discipline within the Department of Civil Engineering at Colorado State University under a recently established NASA Space Grant College Program. Academic programs geared toward creating Space Civil Engineering Options at both undergraduate and graduate levels are being formulated. Basic ideas and concepts of the curriculum in the Space Civil Engineering Option at both undergraduate and graduate levels are presented. The role of Space Civil Engineering in the Space Program is discussed.

Technology Insertion-Engineering Services Process Characterization. Task Order No. 1. Book 2 of 5. Database Documentation Book. OO-ALC MANPRA (C5 Main Landing Gear - WCD’S)

DTIC Science & Technology

1989-12-15

ORDER NO. 1 BOOK 2 OF 5 DATABASE DOCUMENTATION BOOK 00-ALC MANPRA *(C5 MAIN LANDING GEAR- WCD’S) CONTRACT SUMMARY REPORT , 15 DECEMBER 1989 ’.1 - CONTRACT...ORIQ 1 . T A 1~4 M E* X C I" El 1 -:11 E:XCE:EI:IIE:U RE:CORI’ RFiS CvAUiS FOREXE IN REWORK LI[MITS Ill FINAL DESTINATION 22. COOROINATION/INITIATING MCC

An investigation of air transportation technology at the Massachusetts Institute of Technology, 1992-1993

NASA Technical Reports Server (NTRS)

Simpson, Robert W.

1994-01-01

An investigation of air transportation technology at MIT during 1992 - 1993 is presented. One completed project and two continuing research activities are under the sponsorship of the FAA/NASA Joint University Program. The completed project was on tracking aircraft around a turn with wind effects. Active research projects are on ASLOTS - an interactive adaptive system of automated approach spacing of aircraft and alerting in automated and datalink capable cockpits.

SIAM Data Mining Brings It’ to Annual Meeting

DTIC Science & Technology

2017-02-24

address space) languages. Jose Moreira and Manoj Kumar from IBM presented the Graph Programming Interface (GPI) as well as a proposal for a common...Samsi (MIT), Dr. Manoj Kumar (IBM Research), Dr. Michel Kinsy (Boston University), and Dr. Shashank Yellapantula (GE Global Research). Dr. Gadepally...and Dr. Samsi discussed advances in data management technologies [22–25], and Dr. Kumar presented a brief overview of a graph-based API IBM is

KSC-20180409-PH_KLS01_0043

NASA Image and Video Library

2018-04-09

Technicians prepare NASA's Transiting Exoplanet Survey Satellite (TESS) for encapsulation in the SpaceX payload fairing inside the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

KSC-20180409-PH_KLS01_0004

NASA Image and Video Library

2018-04-09

The SpaceX payload fairing that will surround and encapsulate NASA's Transiting Exoplanet Survey Satellite (TESS) is inside the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

KSC-20180409-PH_KLS01_0107

NASA Image and Video Library

2018-04-09

Technicians prepare NASA's Transiting Exoplanet Survey Satellite (TESS) for encapsulation in the SpaceX payload fairing inside the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

SpaceX TESS Fairing Move

NASA Image and Video Library

2018-04-03

The payload fairing for NASA's Transiting Exoplanet Survey Satellite (TESS) is moved inside the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. Inside the facility, TESS will be encapsulated in the payload fairing. The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

KSC-20180409-PH_KLS01_0073

NASA Image and Video Library

2018-04-09

Inside the Payload Hazardous Servicing Facility at NASA's Kennedy Space Center in Florida, NASA's Transiting Exoplanet Survey Satellite (TESS) is being prepared for encapsulation in the SpaceX payload fairing. The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

SpaceX TESS Fairing Move

NASA Image and Video Library

2018-04-03

The payload fairing for NASA's Transiting Exoplanet Survey Satellite (TESS) is being moved to the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. Inside the facility, TESS will be encapsulated in the payload fairing. The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

Kommunikation mit Mitarbeitern

NASA Astrophysics Data System (ADS)

Spychala, Anne; Fleischmann, Jürgen

Kommunikation ist der Austausch von Nachrichten und Informationen zwischen Mitarbeitern eines Unternehmens (O'Hair et al. 1997). Dieser Austausch kann persönlich, aber z.B. auch per Telefon, E-Mail oder durch Computersysteme erfolgen. In diesem Kapitel betrachten wir die persönliche Kommunikation zwischen Vorgesetzten und Mitarbeitern. Zur persönlichen Kommunikation mit Mitarbeitern zählen sowohl formelle Gespräche mit Mitarbeitern als auch eher informelle Gespräche zwischen Tür und Angel. Die Gespräche können dabei mit einzelnen Mitarbeitern (z.B. jährliches Mitarbeitergespräch) oder mit Gruppen von Mitarbeitern (z.B. regelmäßige Projekt- oder Teambesprechungen) stattfinden.

Unfallaufnahme und Datenerhebung

NASA Astrophysics Data System (ADS)

Brösdorf, Klaus-Dieter; Moser, Andreas; Burg, Jürgen

Unfälle ereignen sich in unterschiedlichen Schweregraden. Man unterscheidet zwischen Unfälle mit nur Sachschaden und in Unfälle mit Personenschaden. Gemäß Statistik [1] machten in Deutschland im Jahr 2005 Unfälle mit Personenschaden (336.619) etwa 15 % der Gesamtanzahl der polizeilich erfassten Unfälle (2.253.992) aus. In den amtlichen Statistiken sind nur polizeilich erfasste Unfälle enthalten. Eine größere Zahl von Unfällen, insbesondere leichtere Unfälle, wird offensichtlich polizeilich nicht gemeldet. Mit den Daten der Versicherungswirtschaft wird die Anzahl der Kfz-Schäden pro Jahr in Deutschland mit 8.673.000 angegeben [2].

Mott transition between a spin-liquid insulator and a metal in three dimensions.

PubMed

Podolsky, Daniel; Paramekanti, Arun; Kim, Yong Baek; Senthil, T

2009-05-08

We study a bandwidth controlled Mott metal-insulator transition (MIT) from a Fermi-liquid metal to a quantum spin-liquid insulator in three dimensions. Using a slave rotor approach including gauge fluctuations, we obtain a continuous MIT and discuss finite temperature crossovers in its vicinity. We show that the specific heat C approximately Tlnln(1/T) at the MIT and that the metallic state near the MIT should exhibit a "conductivity minimum" as a function of temperature. We suggest Na4Ir3O8 as a candidate to test our predictions and compute its electron spectral function at the MIT.

Robotics Programming Competition Spheres, Russian Part

NASA Astrophysics Data System (ADS)

Sadovski, Andrei; Kukushkina, Natalia; Biryukova, Natalia

2016-07-01

Spheres" such name was done to Russian part of the Zero Robotics project which is a student competition devoted to programming of SPHERES (SPHERES - Synchronized Position Hold Engage and Reorient Experimental Satellites are the experimental robotics devices which are capable of rotation and translation in all directions, http://ssl.mit.edu/spheres/), which perform different operations on the board of International Space Station. Competition takes place online on http://zerorobotics.mit.edu. The main goal is to develop a program for SPHERES to solve an annual challenge. The end of the tournament is the real competition in microgravity on the board of ISS with a live broadcast. The Russian part of the tournament has only two years history but the problems, organization and specific are useful for the other educational projects especially for the international ones. We introduce the history of the competition, its scientific and educational goals in Russia and describe the participation of Russian teams in 2014 and 2015 tournaments. Also we discuss the organizational problems.

MIT-Skywalker: On the use of a markerless system.

PubMed

Goncalves, Rogerio S; Hamilton, Taya; Krebs, Hermano I

2017-07-01

This paper describes our efforts to employ the Microsoft Kinect as a low cost vision control system for the MIT-Skywalker, a robotic gait rehabilitation device. The Kinect enables an alternative markerless solution to control the MIT-Skywalker and allows a more user-friendly set-up. A study involving eight healthy subjects and two stroke survivors using the MIT-Skywalker device demonstrates the advantages and challenges of this new proposed approach.

Second Chandra Instrument Activated August 28

NASA Astrophysics Data System (ADS)

1999-08-01

Cambridge, MA--NASA's Chandra X-ray Observatory opened a new era in astronomy Saturday, August 28, by making the most precise measurements ever recorded of the energy output from the 10 million degree corona of a star. Last weekend's observations came after the successful activation of an instrument developed by MIT that will allow a one-thousand-fold improvement in the capability to measure X-ray spectra from space. The new measurements, made with the High Energy Transmission Grating Spectrometer, join spectacular images taken last week by Chandra of the aftermath of a gigantic stellar explosion. The spectrometer is one of four key instruments aboard Chandra, and the second to be activated. The others will be turned on over the next two weeks. The spectrometer activated yesterday spreads the X-rays from Chandra's mirrors into a spectrum, much as a prism spreads light into its colors. The spectrum then can be read by Chandra's imaging detectors like a kind of cosmic bar code from which scientists can deduce the chemical composition and temperature of the corona. A corona is a region of hot gas and magnetic loops that extend hundreds of thousands of miles above the star's visible surface and is best studied with X-rays. "The success of the new spectrometer is definitely a major milestone for modern astronomy," said MIT Professor Claude R. Canizares, principal investigator for the instrument and associate director of the Chandra X-ray Observatory Center (CXC). "Within the first hour we had obtained the best X-ray spectrum ever recorded for a celestial source. We can already see unexpected features that will teach us new things about stars and about matter at high temperatures." The spectrometer measured X-rays from the star Capella, which is 40 light years away in the constellation Auriga. Capella is actually two stars orbiting one another and possibly interacting in ways that pump extra heat into the corona, which appears more active than that of the Sun. How a star manages to heat its corona to temperatures a thousand times higher than its own surface is still a puzzle, which astronomers hope can be solved by observations like this one. Other prime targets for Chandra's spectrometers over the next few months include black holes, quasars and supernova explosions. The grating spectrometer consists of hundreds of gold gratings, each about the size of a postage stamp. The surface of each grating resembles a precise picket fence, with microscopic gold pickets 500 times thinner than a human hair. These are spaced every 2000 angstroms, or less than half the wavelength of visible light. The instrument was developed at MIT's Center for Space Research, which Professor Canizares directs, by adapting techniques usually used to make computer chips. Some of these adaptations have found their way back as improvements in the chip-making industry. The grating spectrometer is one of two such devices carried by Chandra. The other, a low-energy grating built by a Dutch-German team, will be activated next week. Chandra also contains two detectors. One, built by researchers at Pennsylvania State University and MIT, was turned on two weeks ago and has recorded all the images and spectra seen so far. The second, built by the Smithsonian Astrophysical Observatory, is being activated this week. Dr. Stephen Murray of the Harvard-Smithsonian Center for Astrophysics summarized the expected impact of Chandra's high resolution X-ray spectroscopy with these words: "A picture is worth a thousand words, a spectrum is worth a million." Capella's spectrum and further information about Chandra's High Energy Transmission Grating Spectrometer may be found at: http://space.mit.edu/CSR/hetg_info.html The Chandra X-ray Observatory Center was named in honor of the late Nobel laureate Subrahmanyan Chandrasekhar. NASA's Marshall Space Flight Center manages the Chandra program. TRW, Inc., Redondo Beach, CA, is the prime contractor for the spacecraft. The Smithsonian Astrophysical Observatory's Chandra X-ray Center controls science and flight operations from Cambridge, MA. The first Chandra images and more information on the Chandra X-ray Observatory Center are available at: http://chandra.harvard.edu and http://chandra.nasa.gov

Stochastic noise characteristics in matrix inversion tomosynthesis (MITS).

PubMed

Godfrey, Devon J; McAdams, H P; Dobbins, James T Third

2009-05-01

Matrix inversion tomosynthesis (MITS) uses known imaging geometry and linear systems theory to deterministically separate in-plane detail from residual tomographic blur in a set of conventional tomosynthesis ("shift-and-add") planes. A previous investigation explored the effect of scan angle (ANG), number of projections (N), and number of reconstructed planes (NP) on the MITS impulse response and modulation transfer function characteristics, and concluded that ANG = 20 degrees, N = 71, and NP = 69 is the optimal MITS imaging technique for chest imaging on our prototype tomosynthesis system. This article examines the effect of ANG, N, and NP on the MITS exposure-normalized noise power spectra (ENNPS) and seeks to confirm that the imaging parameters selected previously by an analysis of the MITS impulse response also yield reasonable stochastic properties in MITS reconstructed planes. ENNPS curves were generated for experimentally acquired mean-subtracted projection images, conventional tomosynthesis planes, and MITS planes with varying combinations of the parameters ANG, N, and NP. Image data were collected using a prototype tomosynthesis system, with 11.4 cm acrylic placed near the image receptor to produce lung-equivalent beam hardening and scattered radiation. Ten identically acquired tomosynthesis data sets (realizations) were collected for each selected technique and used to generate ensemble mean images that were subtracted from individual image realizations prior to noise power spectra (NPS) estimation. NPS curves were normalized to account for differences in entrance exposure (as measured with an ion chamber), yielding estimates of the ENNPS for each technique. Results suggest that mid- and high-frequency noise in MITS planes is fairly equivalent in magnitude to noise in conventional tomosynthesis planes, but low-frequency noise is amplified in the most anterior and posterior reconstruction planes. Selecting the largest available number of projections (N = 71) does not incur any appreciable additive electronic noise penalty compared to using fewer projections for roughly equivalent cumulative exposure. Stochastic noise is minimized by maximizing N and NP but increases with increasing ANG. The noise trend results for NP and ANG are contrary to what would be predicted by simply considering the MITS matrix conditioning and likely result from the interplay between noise correlation and the polarity of the MITS filters. From this study, the authors conclude that the previously determined optimal MITS imaging strategy based on impulse response considerations produces somewhat suboptimal stochastic noise characteristics, but is probably still the best technique for MITS imaging of the chest.

Spirituelles Wohlbefinden und Coping bei Sklerodermie, Lupus erythematodes und malignem Melanom.

PubMed

Pilch, Michaela; Scharf, Sabina Nadine; Lukanz, Martin; Wutte, Nora Johanna; Fink-Puches, Regina; Glawischnig-Goschnik, Monika; Unterrainer, Human-Friedrich; Aberer, Elisabeth

2016-07-01

Religiös-spirituelles Wohlbefinden ist verbunden mit höherer Vitalität und verminderter Depressionsneigung. In unserer Studie untersuchten wir die Strategien zur Krankheitsbewältigung und die Rolle von Religiosität-Spiritualität (R-S) zur Verbesserung des subjektiven Wohlbefindens. 149 Patienten (107 Frauen), 44 mit systemischer Sklerodermie (SKL), 48 mit Lupus erythematodes (LE) und 57 mit malignem Melanom (MM), Stadium I-II, wurden mittels eines selbstentwickelten Fragebogens zum subjektiven Wohlbefinden, zu den mit der Erkrankung einhergehenden Umständen sowie mit dem Multidimensionalen Inventar (MI-RSB) zu R-S befragt. LE-Patienten sind zum Zeitpunkt der Diagnosestellung stärker belastet als SKL- und MM-Patienten. SKL- und LE-Patienten können erst nach Jahren die Erkrankung akzeptieren. Der Gesamtscore des religiös-spirituellen Befindens liegt bei LE-Patienten signifikant unter dem Wert der Normalbevölkerung. Fotosensitivität und Gelenksschmerzen sind bei LE-Patienten negativ assoziiert mit der Fähigkeit Vergeben zu können. SKL-Patienten mit Gesichtsveränderungen und Lungenbeteiligung zeigen höhere allgemeine Religiosität. MM-Patienten haben höhere Werte für transzendente Hoffnung. Vorträge über die Krankheit und psychologische Betreuung sind die wichtigsten Bedürfnisse von Patienten mit SKL, LE und MM an ihre Betreuer. Religiös-spirituelle Angebote zur Krankheitsverarbeitung scheinen derzeit eine untergeordnete Rolle zu spielen, könnten aber eine wichtige Ressource sein, der man in Zukunft mehr Aufmerksamkeit schenken sollte. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Melodic Intonation Therapy in Chronic Aphasia: Evidence from a Pilot Randomized Controlled Trial

PubMed Central

Van Der Meulen, Ineke; Van De Sandt-Koenderman, Mieke W. M. E.; Heijenbrok, Majanka H.; Visch-Brink, Evy; Ribbers, Gerard M.

2016-01-01

Melodic Intonation Therapy (MIT) is a language production therapy for severely non-fluent aphasic patients using melodic intoning and rhythm to restore language. Although many studies have reported its beneficial effects on language production, randomized controlled trials (RCT) examining the efficacy of MIT are rare. In an earlier publication, we presented the results of an RCT on MIT in subacute aphasia and found that MIT was effective on trained and untrained items. Further, we observed a clear trend in improved functional language use after MIT: subacute aphasic patients receiving MIT improved considerably on language tasks measuring connected speech and daily life verbal communication. Here, we present the results of a pilot RCT on MIT in chronic aphasia and compare these to the results observed in subacute aphasia. We used a multicenter waiting-list RCT design. Patients with chronic (>1 year) post-stroke aphasia were randomly allocated to the experimental group (6 weeks MIT) or to the control group (6 weeks no intervention followed by 6 weeks MIT). Assessments were done at baseline (T1), after 6 weeks (T2), and 6 weeks later (T3). Efficacy was evaluated at T2 using univariable linear regression analyses. Outcome measures were chosen to examine several levels of therapy success: improvement on trained items, generalization to untrained items, and generalization to verbal communication. Of 17 included patients, 10 were allocated to the experimental condition and 7 to the control condition. MIT significantly improved repetition of trained items (β = 13.32, p = 0.02). This effect did not remain stable at follow-up assessment. In contrast to earlier studies, we found only a limited and temporary effect of MIT, without generalization to untrained material or to functional communication. The results further suggest that the effect of MIT in chronic aphasia is more restricted than its effect in earlier stages post stroke. This is in line with studies showing larger effects of aphasia therapy in earlier compared to later stages post stroke. The study was designed as an RCT, but was underpowered. The results therefore have to be interpreted cautiously and future larger studies are needed. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NTR 1961. PMID:27847473

Comments on the MIT Assessment of the Mars One Plan

NASA Technical Reports Server (NTRS)

Jones, Harry W.

2015-01-01

The MIT assessment of the Mars One mission plan reveals design assumptions that would cause significant difficulties. Growing crops in the crew chamber produces excessive oxygen levels. The assumed in-situ resource utilization (ISRU) equipment has too low a Technology Readiness Level (TRL). The required spare parts cause a large and increasing launch mass logistics burden. The assumed International Space Station (ISS) Environmental Control and Life Support (ECLS) technologies were developed for microgravity and therefore are not suitable for Mars gravity. Growing food requires more mass than sending food from Earth. The large number of spares is due to the relatively low reliability of ECLS and the low TRL of ISRU. The Mars One habitat design is similar to past concepts but does not incorporate current knowledge. The MIT architecture analysis tool for long-term settlements on the Martian surface includes an ECLS system simulation, an ISRU sizing model, and an analysis of required spares. The MIT tool showed the need for separate crop and crew chambers, the large spare parts logistics, that crops require more mass than Earth food, and that more spares are needed if reliability is lower. That ISRU has low TRL and ISS ECLS was designed for microgravity are well known. Interestingly, the results produced by the architecture analysis tool - separate crop chamber, large spares mass, large crop chamber mass, and low reliability requiring more spares - were also well known. A common approach to ECLS architecture analysis is to build a complex model that is intended to be all-inclusive and is hoped will help solve all design problems. Such models can struggle to replicate obvious and well-known results and are often unable to answer unanticipated new questions. A better approach would be to survey the literature for background knowledge and then directly analyze the important problems.

On the Analysis Methods for the Time Domain and Frequency Domain Response of a Buried Objects*

NASA Astrophysics Data System (ADS)

Poljak, Dragan; Šesnić, Silvestar; Cvetković, Mario

2014-05-01

There has been a continuous interest in the analysis of ground-penetrating radar systems and related applications in civil engineering [1]. Consequently, a deeper insight of scattering phenomena occurring in a lossy half-space, as well as the development of sophisticated numerical methods based on Finite Difference Time Domain (FDTD) method, Finite Element Method (FEM), Boundary Element Method (BEM), Method of Moments (MoM) and various hybrid methods, is required, e.g. [2], [3]. The present paper deals with certain techniques for time and frequency domain analysis, respectively, of buried conducting and dielectric objects. Time domain analysis is related to the assessment of a transient response of a horizontal straight thin wire buried in a lossy half-space using a rigorous antenna theory (AT) approach. The AT approach is based on the space-time integral equation of the Pocklington type (time domain electric field integral equation for thin wires). The influence of the earth-air interface is taken into account via the simplified reflection coefficient arising from the Modified Image Theory (MIT). The obtained results for the transient current induced along the electrode due to the transmitted plane wave excitation are compared to the numerical results calculated via an approximate transmission line (TL) approach and the AT approach based on the space-frequency variant of the Pocklington integro-differential approach, respectively. It is worth noting that the space-frequency Pocklington equation is numerically solved via the Galerkin-Bubnov variant of the Indirect Boundary Element Method (GB-IBEM) and the corresponding transient response is obtained by the aid of inverse fast Fourier transform (IFFT). The results calculated by means of different approaches agree satisfactorily. Frequency domain analysis is related to the assessment of frequency domain response of dielectric sphere using the full wave model based on the set of coupled electric field integral equations for surfaces. The numerical solution is carried out by means of the improved variant of the Method of Moments (MoM) providing numerically stable and an efficient procedure for the extraction of singularities arising in integral expressions. The proposed analysis method is compared to the results obtained by using some commercial software packages. A satisfactory agreement has been achieved. Both approaches discussed throughout this work and demonstrated on canonical geometries could be also useful for benchmark purpose. References [1] L. Pajewski et al., Applications of Ground Penetrating Radar in Civil Engineering - COST Action TU1208, 2013. [2] U. Oguz, L. Gurel, Frequency Responses of Ground-Penetrating Radars Operating Over Highly Lossy Grounds, IEEE Trans. Geosci. and Remote sensing, Vol. 40, No 6, 2002. [3] D.Poljak, Advanced Modeling in Computational electromagnetic Compatibility, John Wiley and Sons, New York 2007. *This work benefited from networking activities carried out within the EU funded COST Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar."

Fuzzy logic application for modeling man-in-the-loop space shuttle proximity operations. M.S. Thesis - MIT

NASA Technical Reports Server (NTRS)

Brown, Robert B.

1994-01-01

A software pilot model for Space Shuttle proximity operations is developed, utilizing fuzzy logic. The model is designed to emulate a human pilot during the terminal phase of a Space Shuttle approach to the Space Station. The model uses the same sensory information available to a human pilot and is based upon existing piloting rules and techniques determined from analysis of human pilot performance. Such a model is needed to generate numerous rendezvous simulations to various Space Station assembly stages for analysis of current NASA procedures and plume impingement loads on the Space Station. The advantages of a fuzzy logic pilot model are demonstrated by comparing its performance with NASA's man-in-the-loop simulations and with a similar model based upon traditional Boolean logic. The fuzzy model is shown to respond well from a number of initial conditions, with results typical of an average human. In addition, the ability to model different individual piloting techniques and new piloting rules is demonstrated.

TESS Spacecraft Arrival

NASA Image and Video Library

2018-02-12

NASA's Transiting Exoplanet Survey Satellite (TESS), inside its shipping container, is moved into Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Solar Panel Array Deployment Testing

NASA Image and Video Library

2018-02-21

Inside the Payload Hazardous Servicing Facility at the NASA's Kennedy Space Center in Florida, both solar panels are deployed on the agency's Transiting Exoplanet Survey Satellite (TESS). The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Arrival

NASA Image and Video Library

2018-02-12

The shipping container with NASA's Transiting Exoplanet Survey Satellite (TESS) inside, is moved into the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Uncrating

NASA Image and Video Library

2018-02-12

The shipping container with NASA's Transiting Exoplanet Survey Satellite (TESS) arrives inside the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. Inside the PHSF, TESS will be unpacked, lifted up and moved to a test stand for processing. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Solar Panel Array Deployment Testing

NASA Image and Video Library

2018-02-21

Inside the Payload Hazardous Servicing Facility at the NASA's Kennedy Space Center in Florida, the first of two solar panels is being deployed on the agency's Transiting Exoplanet Survey Satellite (TESS). The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Arrival

NASA Image and Video Library

2018-02-12

NASA's Transiting Exoplanet Survey Satellite (TESS), inside its shipping container, is backed in on flatbed truck to the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Solar Panel Array Deployment Testing

NASA Image and Video Library

2018-02-21

Inside the Payload Hazardous Servicing Facility at the NASA's Kennedy Space Center in Florida, one of the solar panels is being deployed on the agency's Transiting Exoplanet Survey Satellite (TESS). Technicians are preparing to deploy the second solar array. The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Solar Panel Array Deployment Testing

NASA Image and Video Library

2018-02-21

Preparations are underway for solar panel deployment on NASA's Transiting Exoplanet Survey Satellite (TESS) inside the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Solar Array Deploy

NASA Image and Video Library

2018-02-21

Inside the Payload Hazardous Servicing Facility at the NASA's Kennedy Space Center in Florida, technicians test the solar array deploy panels on the agency's Transiting Exoplanet Survey Satellite (TESS). The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Arrival

NASA Image and Video Library

2018-02-12

NASA's Transiting Exoplanet Survey Satellite (TESS) container is pressure washed at the Multi-Payload Processing Facility at the agency's Kennedy Space Center in Florida. Tess will be moved to the Payload Hazardous Servicing Facility to be processed and prepared for flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Arrival

NASA Image and Video Library

2018-02-12

NASA's Transiting Exoplanet Survey Satellite (TESS), inside its shipping container arrives at the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

Overview and Status of the Lunar Laser Communication Demonstration

NASA Technical Reports Server (NTRS)

Boroson, D. M.; Robinson, B. S.; Burianek, D. A.; Murphy, D. V.; Biswas, A.

2012-01-01

The Lunar Laser Communication Demonstration (LLCD), a project being undertaken by MIT Lincoln Laboratory, NASA's Goddard Space Flight Center, and the Jet Propulsion Laboratory, will be NASA's first attempt to demonstrate optical communications between a lunar orbiting spacecraft and Earth-based ground receivers. The LLCD space terminal will be flown on the Lunar Atmosphere and Dust Environment Explorer (LADEE) spacecraft, presently scheduled to launch in 2013. LLCD will demonstrate downlink optical communications at rates up to 620 Mbps, uplink optical communications at rates up to 20 Mbps, and two-way time-of-flight measurements with the potential to perform ranging with sub-centimeter accuracy. We describe the objectives of the LLCD program, key technologies employed in the space and ground terminals, and show the status of development of the several systems.

NASA Science Review of Next Planet-Hunting Mission Launch

NASA Image and Video Library

2018-04-15

NASA and science investigators from MIT participate in a science briefing for the agency's Transiting Exoplanet Survey Satellite (TESS) in the Press Site auditorium at Kennedy Space Center in Florida. Diana Dragomir, NASA Hubble Postdoctoral Fellow, Massachusetts Institute of Technology, answered questions during the briefing. TESS is the next step in the search for planets outside of our solar system. The mission will find exoplanets that periodically block part of the light from their host stars, events called transits. The satellite will survey the nearest and brightest stars for two years to search for transiting exoplanets. TESS will launch on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station no earlier than 6:32 p.m. EDT on Monday, April 16.

NASA Science Review of Next Planet-Hunting Mission Launch

NASA Image and Video Library

2018-04-15

NASA and science investigators from MIT participate in a science briefing for the agency's Transiting Exoplanet Survey Satellite (TESS) in the Press Site auditorium at Kennedy Space Center in Florida. George Ricker, TESS principal investigator, Massachusetts Institute of Technology, answered questions during the briefing. TESS is the next step in the search for planets outside of our solar system. The mission will find exoplanets that periodically block part of the light from their host stars, events called transits. The satellite will survey the nearest and brightest stars for two years to search for transiting exoplanets. TESS will launch on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station no earlier than 6:32 p.m. EDT on Monday, April 16.

Affective Responses to Repeated Sessions of High-Intensity Interval Training.

PubMed

Saanijoki, Tiina; Nummenmaa, Lauri; Eskelinen, Jari-Joonas; Savolainen, Anna M; Vahlberg, Tero; Kalliokoski, Kari K; Hannukainen, Jarna C

2015-12-01

Vigorous exercise feels unpleasant, and negative emotions may discourage adherence to regular exercise. We quantified the subjective affective responses to short-term high-intensity interval training (HIT) in comparison with moderate-intensity continuous training (MIT). Twenty-six healthy middle-age (mean age, 47 ± 5 yr; mean VO2peak, 34.2 ± 4.1 mL·kg⁻¹·min⁻¹) sedentary men were randomized into HIT (n = 13, 4-6 × 30 s of all-out cycling efforts at approximately 180% of peak workload with 4-min recovery) or MIT (n = 13, 40- to 60-min continuous cycling at 60% of peak workload) groups, performing six sessions within two weeks. Perceived exertion, stress, and affective state were recorded before, during, and after each session. Perceived exertion and arousal were higher, and affective state, more negative during the HIT than that during MIT sessions (P < 0.001). HIT versus MIT exercise acutely increased the experience of stress, tension, and irritation and decreased positive affect (P < 0.05). In addition, satisfaction was lower and pain and negative affect were higher in the HIT than those in the MIT group (P < 0.05). However, perceived exertion and displeasure experienced during exercise alleviated similarly in response to HIT and MIT over the 6 d of training. Peak oxygen consumption increased (P < 0.001) after intervention (HIT, 34.7 ± 3.9 vs 36.7 ± 4.5; MIT, 33.9 ± 4.6 vs 35.0 ± 4.6) and was not different between HIT and MIT (P = 0.28 for group × training). Short-term HIT and MIT are equally effective in improving aerobic fitness, but HIT increases experience of negative emotions and exertion in sedentary middle-age men. This may limit the adherence to this time-effective training mode, even though displeasure lessens over time and suggests similar mental adaptations to both MIT and HIT.

Strong Artificial Intelligence and National Security: Operational and Strategic Implications

DTIC Science & Technology

2015-05-18

including Tesla/Space X founder Elon Musk and theoretical physicist Stephen Hawking, released an open letter warning of the existential risk presented by...the MIT Aeronautics and Astronautics Department’s 2014 Centennial Symposium, Elon Musk , a member of FLI, said that creating such a capable...pentagram and the holy water, it’s like yeah he’s sure he can control the demon. Didn’t work out.” Elon Musk , interview by Jaime Peraire, 2014

Graphical timeline editing

NASA Technical Reports Server (NTRS)

Meyer, Patrick E.; Jaap, John P.

1994-01-01

NASA's Experiment Scheduling Program (ESP), which has been used for approximately 12 Spacelab missions, is being enhanced with the addition of a Graphical Timeline Editor. The GTE Clipboard, as it is called, was developed to demonstrate new technology which will lead the development of International Space Station Alpha's Payload Planning System and support the remaining Spacelab missions. ESP's GTE Clipboard is developed in C using MIT's X Windows System X11R5 and follows OSF/Motif Style Guide Revision 1.2.

Detecting Man-in-the-Middle Attacks against Transport Layer Security Connections with Timing Analysis

DTIC Science & Technology

2011-09-15

Networks (VPNs), TLS protects massive amounts of private information, and protecting this data from Man-in-the-Middle ( MitM ) attacks is imperative to...keeping the information secure. This thesis illustrates how an attacker can successfully perform a MitM attack against a TLS connection without alerting...mechanism a user has against a MitM . The goal for this research is to determine if a time threshold exists that can indicate the presence of a MitM in this

The My Meal Intake Tool (M-MIT): Validity of a Patient Self- Assessment for Food and Fluid Intake at a Single Meal.

PubMed

McCullough, J; Keller, H

2018-01-01

Hospital malnutrition is an under-recognized issue that leads to a variety of adverse outcomes, especially for older adults. Food/fluid intake (FFI) monitoring in hospital can be used to identify those who are improving and those who need further treatment. Current monitoring practices such as calorie counts are impractical for all patients and a patient-completed tool, if valid, could support routine FFI monitoring. The aim of this research was to determine whether the patient-completed My Meal Intake Tool (M-MIT) can accurately represent FFI at a single meal. Cross-sectional, multi-site. Four acute care hospitals in Canada. 120 patients (65+ yrs, adequate cognition). Participants completed M-MIT for a single meal. Food and fluid waste was visually estimated by a research dietitian at each hospital. Sensitivity (Se), specificity (Sp) and overall agreement were calculated for both food and fluid intake by comparing M-MIT and dietitian estimations to determine criterion validity of M-MIT. Patient and research dietitian comments were used to make revisions to the M-MIT. Using a cut-point of ≤50% intake, Se was 76.2% and 61.9% and Sp was 74.0% and 80.5% for solid and fluids respectively (p<0.001). M-MIT identified a greater proportion of participants (37.2%) as having low FFI (≤50%) than dietitians (25.0%), as well as a greater proportion identified with low fluid intake (28.3% vs. 24.6%). Modest revisions were made to improve the tool. This study has demonstrated initial validity of M-MIT for use in older patients with adequate cognition. Use of M-MIT could promote FFI monitoring as a routine practice to make clinical decisions about care.

Effective degradation of methylisothiazolone biocide using ozone: Kinetics, mechanisms, and decreases in toxicity.

PubMed

Li, Ang; Wu, Qian-Yuan; Tian, Gui-Peng; Hu, Hong-Ying

2016-12-01

Methylisothiazolone (MIT) is a common biocide that is widely used in water-desalination reverse-osmosis processes. The transformation of MIT during water treatment processes is poorly understood. The kinetics and mechanisms involved in the degradation of MIT during ozonation were investigated in this study. Ozonation was found to be a useful way of degrading MIT in water, and the degradation rate constant was 0.11 (±0.1) × 10 3  L/(mol·s). The degradation rate constant did not change when the pH was increased from 3 to 9. The pre-exponential factor A and the activation energy E a for the ozonation process were 7.564 × 10 13  L/(mol·s) and 66.74 kJ/mol, respectively. The decrease in the MIT concentration and the amount of ozone consumed were measured, and the stoichiometric factor α for the ozone consumption to MIT removal ratio was found to be 1.8. Several ozonation products were detected using time-of-flight mass spectrometry. Almost 32% of the organic sulfur in the MIT was oxidized to release sulfate ions, which caused a decrease in pH. Sulfur atoms were oxidized to sulfone species and then hydrolyzed to give sulfate during ozonation. Addition reactions involving carbon-carbon double bonds and the oxidation of α-carbon atoms also occurred. MIT was found to be lethal to Daphnia magna Straus (D. magna) with a median lethal concentration of 18.2 μmol/L. Even though the primary ozonation products of MIT still showed some toxicity to D. magna, ozone could minimize the toxic effect after a long reaction time. Copyright © 2016 Elsevier Ltd. All rights reserved.

Space Civil Engineering option - A progress report

NASA Technical Reports Server (NTRS)

Criswell, Marvin E.; Sadeh, Willy Z.

1992-01-01

Space Civil Engineering is an emerging engineering discipline that focuses on extending and expanding Civil Engineering to the development, operation, and maintenance of infrastructures on celestial bodies. Space Civil Engineering is presently being developed as a new discipline within the Department of Civil Engineering at Colorado State University and with support of the NASA Space Grant College Program. Academic programs geared toward creating Space Civil Engineering Options at both undergraduate and graduate levels are being formulated. Basic ideas and concepts and the current status of the curriculum in the Space Civil Engineering Option primarily at the undergraduate level are presented.

Improved Neural Processing Efficiency in a Chronic Aphasia Patient Following Melodic Intonation Therapy: A Neuropsychological and Functional MRI Study

PubMed Central

Tabei, Ken-ichi; Satoh, Masayuki; Nakano, Chizuru; Ito, Ai; Shimoji, Yasuo; Kida, Hirotaka; Sakuma, Hajime; Tomimoto, Hidekazu

2016-01-01

Melodic intonation therapy (MIT) is a treatment program for the rehabilitation of aphasic patients with speech production disorders. We report a case of severe chronic non-fluent aphasia unresponsive to several years of conventional therapy that showed a marked improvement following intensive 9-day training on the Japanese version of MIT (MIT-J). The purpose of this study was to verify the efficacy of MIT-J by functional assessment and examine associated changes in neural processing by functional magnetic resonance imaging. MIT improved language output and auditory comprehension, and decreased the response time for picture naming. Following MIT-J, an area of the right hemisphere was less activated on correct naming trials than compared with before training but similarly activated on incorrect trials. These results suggest that the aphasic symptoms of our patient were improved by increased neural processing efficiency and a concomitant decrease in cognitive load. PMID:27698650

Modulation of mitochondrial activity in HaCaT keratinocytes by the cell penetrating peptide Z-Gly-RGD(DPhe)-mitoparan.

PubMed

Richardson, Adam; Muir, Lewis; Mousdell, Sasha; Sexton, Darren; Jones, Sarah; Howl, John; Ross, Kehinde

2018-01-30

Biologically active cell penetrating peptides (CPPs) are an emerging class of therapeutic agent. The wasp venom peptide mastoparan is an established CPP that modulates mitochondrial activity and triggers caspase-dependent apoptosis in cancer cells, as does the mastoparan analogue mitoparan (mitP). Mitochondrial depolarisation and activation of the caspase cascade also underpins the action of dithranol, a topical agent for treatment of psoriasis. The effects of a potent mitP analogue on mitochondrial activity were therefore examined to assess its potential as a novel approach for targeting mitochondria for the treatment of psoriasis. In HaCaT keratinocytes treated with the mitP analogue Z-Gly-RGD(DPhe)-mitP for 24 h, a dose-dependent loss of mitochondrial activity was observed using the methyl-thiazolyl-tetrazolium (MTT) assay. At 10 μmol L -1 , MTT activity was less than 30% that observed in untreated cells. Staining with the cationic dye JC-1 suggested that Z-Gly-RGD(DPhe)-mitP also dissipated the mitochondrial membrane potential, with a threefold increase in mitochondrial depolarisation levels. However, caspase activity appeared to be reduced by 24 h exposure to Z-Gly-RGD(DPhe)-mitP treatment. Furthermore, Z-Gly-RGD(DPhe)-mitP treatment had little effect on overall cell viability. Our findings suggest Z-Gly-RGD(DPhe)-mitP promotes the loss of mitochondrial activity but does not appear to evoke apoptosis in HaCaT keratinocytes.

Tracking moving identities: after attending the right location, the identity does not come for free.

PubMed

Pinto, Yaïr; Scholte, H Steven; Lamme, V A F

2012-01-01

Although tracking identical moving objects has been studied since the 1980's, only recently the study into tracking moving objects with distinct identities has started (referred to as Multiple Identity Tracking, MIT). So far, only behavioral studies into MIT have been undertaken. These studies have left a fundamental question regarding MIT unanswered, is MIT a one-stage or a two-stage process? According to the one-stage model, after a location has been attended, the identity is released without effort. However, according to the two-stage model, there are two effortful stages in MIT, attending to a location, and attending to the identity of the object at that location. In the current study we investigated this question by measuring brain activity in response to tracking familiar and unfamiliar targets. Familiarity is known to automate effortful processes, so if attention to identify the object is needed, this should become easier. However, if no such attention is needed, familiarity can only affect other processes (such as memory for the target set). Our results revealed that on unfamiliar trials neural activity was higher in both attentional networks, and visual identification networks. These results suggest that familiarity in MIT automates attentional identification processes, thus suggesting that attentional identification is needed in MIT. This then would imply that MIT is essentially a two-stage process, since after attending the location, the identity does not seem to come for free.

SpaceX TESS Payload Lift to Trailer; Prep for Transport to LC 40

NASA Image and Video Library

2018-04-11

Inside the Payload Hazardous Servicing Facility at NASA's Kennedy Space Center in Florida, the SpaceX payload fairing containing the agency's Transiting Exoplanet Survey Satellite (TESS) is secured onto a transporter. The fairing will be moved to Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is scheduled to launch on the SpaceX Falcon 9 rocket at 6:32 p.m. EDT on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

SpaceX TESS Payload Lift to Trailer; Prep for Transport to LC 40

NASA Image and Video Library

2018-04-11

Inside the Payload Hazardous Servicing Facility at NASA's Kennedy Space Center in Florida, technicians assist as the SpaceX payload fairing containing the agency's Transiting Exoplanet Survey Satellite (TESS) is lifted for the move to a transporter. The fairing will be moved to Space Launch Complex 40 at Cape Canaveral Air Force Station. The satellite is scheduled to launch atop the SpaceX Falcon 9 rocket at 6:32 p.m. EDT on April 16. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

SpaceX TESS Payload Lift to Trailer; Prep for Transport to LC 40

NASA Image and Video Library

2018-04-11

Inside the Payload Hazardous Servicing Facility at NASA's Kennedy Space Center in Florida, technicians assist as the SpaceX payload fairing containing the agency's Transiting Exoplanet Survey Satellite (TESS) is lowered by crane onto a transporter. The fairing will be moved to Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is scheduled to launch on the SpaceX Falcon 9 rocket at 6:32 p.m. EDT on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

SpaceX TESS Payload Lift to Trailer; Prep for Transport to LC 40

NASA Image and Video Library

2018-04-11

The SpaceX payload fairing containing NASA's Transiting Exoplanet Survey Satellite (TESS) is prepared for the move from the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida to Space Launch Complex 40 at Cape Canaveral Air Force Station. The satellite is scheduled to launch atop the SpaceX Falcon 9 rocket at 6:32 p.m. EDT on April 16. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

SpaceX TESS Payload Lift to Trailer; Prep for Transport to LC 40

NASA Image and Video Library

2018-04-11

Inside the Payload Hazardous Servicing Facility at NASA's Kennedy Space Center in Florida, technicians assist as the SpaceX payload fairing containing the agency's Transiting Exoplanet Survey Satellite (TESS) is moved by crane to a transporter. The fairing will be moved to Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is scheduled to launch on the SpaceX Falcon 9 rocket at 6:32 p.m. EDT on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

OFFICIAL PORTRAIT - STS-9 CREW

NASA Image and Video Library

1983-06-29

S83-35017 (June 1983) --- These six men represent the first crewmembers to man the Columbia when it gets reactivated later this year. The four NASA astronauts are joined by a European and MIT scientist payload specialist and the Spacelab module and experiment array for STS-9. On the front row are Astronauts Owen K. Garriott, mission specialist; Brewster H. Shaw, Jr., pilot; John W. Young, commander; and Robert A. R. Parker, mission specialist. Byron K. Lichtenberg of the Massachusetts of Technology, left and Ulf Merbold of the Republic of West Germany and the European Space Agency stand in front of an orbital scene featuring the Columbia. Columbia was used for the first five Space Transportation System missions in 1981 and 1982.

Collins Cryocooler Design for Zero-Boil Storage of Liquid Hydrogen and Oxygen in Space

NASA Astrophysics Data System (ADS)

Segado, M. A.; Hannon, C. L.; Brisson, J. G.

2010-04-01

Several models of multi-stage cryocoolers are developed for zero-boil-off storage of liquid hydrogen and oxygen in space. The thermodynamic cycles are based on a modified Collins cycle being developed by MIT and AMTI, and each configuration is optimized for maximum efficiency by varying the mass flows, heat exchanger UA distribution, and other variables where applicable, subject to the required heat loads of 100 W at 100 K and 20 W at 25 K. By using double expanders connected in series with the heat loads in one or more stages of the cooler, we were able to achieve predicted efficiency gains of 10-24% over single expander designs.

On directionality of phrase structure building.

PubMed

Chesi, Cristiano

2015-02-01

Minimalism in grammatical theorizing (Chomsky in The minimalist program. MIT Press, Cambridge, 1995) led to simpler linguistic devices and a better focalization of the core properties of the structure building engine: a lexicon and a free (recursive) phrase formation operation, dubbed Merge, are the basic components that serve in building syntactic structures. Here I suggest that by looking at the elementary restrictions that apply to Merge (i.e., selection and licensing of functional features), we could conclude that a re-orientation of the syntactic derivation (from bottom-up/right-left to top-down/left-right) is necessary to make the theory simpler, especially for long-distance (filler-gap) dependencies, and is also empirically more adequate. If the structure building operations would assemble lexical items in the order they are pronounced (Phillips in Order and structure. PhD thesis, MIT, 1996; Chesi in Phases and cartography in linguistic computation: Toward a cognitively motivated computational model of linguistic competence. PhD thesis, Università di Siena, 2004; Chesi in Competence and computation: Toward a processing friendly minimalist grammar. Unipress, Padova, 2012), on-line performance data could better fit the grammatical model, without resorting to external "performance factors." The phase-based, top-down (and, as a consequence, left-right) Minimalist Grammar here discussed goes in this direction, ultimately showing how strong Islands (Huang in Logical relations in Chinese and the theory of grammar. PhD thesis, MIT, 1982) and intervention effects (Gordon et al. in J Exp Psychol Learn Mem Cogn 27:1411-1423, 2001, Gordon et al. in J Mem Lang 51:97-114, 2004) could be better explained in structural terms assuming this unconventional derivational direction.

Teaching ``The Physics of Energy'' at MIT

NASA Astrophysics Data System (ADS)

Jaffe, Robert

2009-05-01

New physics courses on energy are popping up at colleges and universities across the country. Many require little or no previous physics background, aiming to introduce a broad audience to this complex and critical problem, often augmenting the scientific message with economic and policy discussions. Others are advanced courses, focussing on highly specialized subjects like solar voltaics, nuclear physics, or thermal fluids, for example. About two years ago Washington Taylor and I undertook to develop a course on the ``Physics of Energy'' open to all MIT students who had taken MIT's common core of university level calculus, physics, and chemistry. By avoiding higher level prerequisites, we aimed to attract and make the subject relevant to students in the life sciences, economics, etc. --- as well as physical scientists and engineers --- who want to approach energy issues in a sophisticated and analytical fashion, exploiting their background in calculus, mechanics, and E & M, but without having to take advanced courses in thermodynamics, quantum mechanics, or nuclear physics beforehand. Our object was to interweave teaching the fundamental physics principles at the foundations of energy science with the applications of those principles to energy systems. We envisioned a course that would present the basics of statistical, quantum, and fluid mechanics at a fairly sophisticated level and apply those concepts to the study of energy sources, conversion, transport, losses, storage, conservation, and end use. In the end we developed almost all of the material for the course from scratch. The course debuted this past fall. I will describe what we learned and what general lessons our experience might have for others who contemplate teaching energy physics broadly to a technically sophisticated audience.

Physik gestern und heute: Visualisierung mit der Schlierenmethode

NASA Astrophysics Data System (ADS)

Heering, Peter

2006-07-01

Der Name des österreichischen Forschers Ernst Mach ist heute noch mit der Schallgeschwindigkeit verbunden. Diese Auszeichnung resultiert aus Machs Untersuchungen, wie sich Projektile mit Überschallgeschwindigkeit durch die Luft bewegen. Gerade in jüngster Zeit hat die Anwendung derartiger Methoden durch technische Modifikationen wieder einen Aufschwung erfahren.

Exploring Surfaces of Nanomaterials - MIT Spectrum

Science.gov Websites

Topics About Search for: Search Massachusetts Institute of Technology Yang Shao-Horn is tackling the inspired by them to work here." Learn More Yang Shao-Horn Topics battery Energy Materials Science Latest Stories Spectrum Issues Topics About Popular Latest MIT Campaign for a Better World MIT Campaign

Historisches Rätsel Physik mit Gewehr und Eiern

NASA Astrophysics Data System (ADS)

Loos, Andreas

2003-11-01

Es fing schon gut an: Mit zehn Jahren saß der begabte Junge bereits in der Universität, wo ihn kein Geringerer als sein Vater persönlich unterrichtete. Damit schlug dieser zwei Fliegen mit einer Klappe: Sein Sohn lernte etwas Gescheites, und er war zugleich in sicherer Obhut.

Announcing the Availability of the MIT SMASS and SMASSIR Data Sets

NASA Technical Reports Server (NTRS)

Binzel, R. P.; Bus, S. J.; Burbine, T. H.; Rivkin, A. S.

2001-01-01

We announce the release of visible and near-infrared reflectance spectroscopy measurements for nearly 2000 asteroids obtained by the MIT Small Main-Belt Asteroid Spectroscopic Survey (SMASS) program. Data are being released via http://smass.mit.edu. Additional information is contained in the original extended abstract.

Minimum ignition temperature of nano and micro Ti powder clouds in the presence of inert nano TiO2 powder.

PubMed

Yuan, Chunmiao; Amyotte, Paul R; Hossain, Md Nur; Li, Chang

2014-06-30

Minimum ignition temperature (MIT) of micro Ti powder increased gradually with increases in nano-sized TiO2 employed as an inertant. Solid TiO2 inertant significantly reduced ignition hazard of micro Ti powder in contact with hot surfaces. The MIT of nano Ti powder remained low (583 K), however, even with 90% TiO2. The MIT of micro Ti powder, when mixed with nano Ti powder at concentrations as low as 10%, decreased so dramatically that its application as a solid fuel may be possible. A simple MIT model was proposed for aggregate particle size estimation and better understanding of the inerting effect of nano TiO2 on MIT. Estimated particle size was 1.46-1.51 μm larger than that in the 20-L sphere due to poor dispersion in the BAM oven. Calculated MITs were lower than corresponding empirically determined values for micro Ti powder because nano-sized TiO2 coated the micro Ti powder, thereby decreasing its reaction kinetics. In the case of nano Ti powder, nano-sized TiO2 facilitated dispersion of nano Ti powder which resulted in a calculated MIT that was greater than the experimentally determined value. Copyright © 2014 Elsevier B.V. All rights reserved.

Best practice for motor imagery: a systematic literature review on motor imagery training elements in five different disciplines

PubMed Central

2011-01-01

Background The literature suggests a beneficial effect of motor imagery (MI) if combined with physical practice, but detailed descriptions of MI training session (MITS) elements and temporal parameters are lacking. The aim of this review was to identify the characteristics of a successful MITS and compare these for different disciplines, MI session types, task focus, age, gender and MI modification during intervention. Methods An extended systematic literature search using 24 databases was performed for five disciplines: Education, Medicine, Music, Psychology and Sports. References that described an MI intervention that focused on motor skills, performance or strength improvement were included. Information describing 17 MITS elements was extracted based on the PETTLEP (physical, environment, timing, task, learning, emotion, perspective) approach. Seven elements describing the MITS temporal parameters were calculated: study duration, intervention duration, MITS duration, total MITS count, MITS per week, MI trials per MITS and total MI training time. Results Both independent reviewers found 96% congruity, which was tested on a random sample of 20% of all references. After selection, 133 studies reporting 141 MI interventions were included. The locations of the MITS and position of the participants during MI were task-specific. Participants received acoustic detailed MI instructions, which were mostly standardised and live. During MI practice, participants kept their eyes closed. MI training was performed from an internal perspective with a kinaesthetic mode. Changes in MI content, duration and dosage were reported in 31 MI interventions. Familiarisation sessions before the start of the MI intervention were mentioned in 17 reports. MI interventions focused with decreasing relevance on motor-, cognitive- and strength-focused tasks. Average study intervention lasted 34 days, with participants practicing MI on average three times per week for 17 minutes, with 34 MI trials. Average total MI time was 178 minutes including 13 MITS. Reporting rate varied between 25.5% and 95.5%. Conclusions MITS elements of successful interventions were individual, supervised and non-directed sessions, added after physical practice. Successful design characteristics were dominant in the Psychology literature, in interventions focusing on motor and strength-related tasks, in interventions with participants aged 20 to 29 years old, and in MI interventions including participants of both genders. Systematic searching of the MI literature was constrained by the lack of a defined MeSH term. PMID:21682867

6. Photocopy of drawing. (This drawing is an 8' x ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Photocopy of drawing. (This drawing is an 8' x 10' enlargement from a 4' x 5' negative; 1942 drawing titled 'Mess Halls; Types M-B-T, M-C-T, M-D-T, M-E-T, M-G-T, M-H-T, M-I-T, M-K-T, M-L-T, M-M-T & M-N-T; Electrical,' Plan No. T.O. 700-6601, located at Directorate of Engineering and Housing, Fort McPherson.) - Fort McPherson, World War II Station Hospital, G. U. Treatment Unit Mess Hall, Thorne & Hood Avenues, Atlanta, Fulton County, GA

Proceedings, U.S. Army Corps of Engineers Seminar on Water Project Financing Held at Fort Belvoir, Virginia on 16-17 May 1984.

DTIC Science & Technology

1984-10-01

DAMmwrams, 2.0 2.7 Minicipal Waer b~pply 3.7 8.0 1ftt t rTreatmnt 5.9 7.3 */ art vatenmya, and flood control. Doss not Includeipadutl $3.7 billion in...Department. Please see PA.KS, Page 3 Cryder was an early advocate of the innovative entrepreneurial strategy By KEVIN RODERICK, and has made the county...Joint Agency Financing." I . .. Finace iviionat mit Baneyinvovin waer n ydreletr* prjet. "-". Robert B. Nolan, Jr. Senior Vice President Blyth Eastman

Proceedings of the European ISTVS Conference (6th), OVK Symposium (4th), on "Off Road Vehicles in Theory and Practice", Held at Vienna, Austria on 28-30 September 1994. Appendix.

DTIC Science & Technology

1994-09-30

Experimentalfahrzeug 8x DipL-fng. W. Slinkell Mercedes - Benz AG Stuttgart, Deutschland 3 Zumn Nachweis hoher Mobilittit wurde 1986 ein Experimentalfahrzeug Mx mit...propulsed by a 6 cylinder turbo charged Diesel engine from the passenger car series by Mercedes Benz and which is also equipped with an automatic...transmission by Mercedes Benz reaches 52 kilometers per hour when being used on the road and 4 km/h when swimming through water. II I i i DESIGN FEATURES I

Preliminary Reports, Memoranda and Technical Notes of the Materials Research Council Summer Conference, La Jolla, California

DTIC Science & Technology

1984-07-01

Faurie U of Illinois 312-996-2141 A.D. Morrison Jet Propulsion Lab 213-354- 7200 A.R. Calawa Lincoln Lab, MIT 617-863-550C Ron Kerber DARPA 202-694...environment can only be assessed following extensive experimentation in space.2 mM Considering the failure of all efforts to suppress, during growth on earth ... earth because of constitutional supercooling effect. For oxide systems, the possibility exists to establish non-wetting configurations and thus to avoid

Walking a mile in another's shoes: The impact of wearing an Age Suit.

PubMed

Lavallière, Martin; D'Ambrosio, Lisa; Gennis, Angelina; Burstein, Arielle; Godfrey, Kathryn M; Waerstad, Hilde; Puleo, Rozanne M; Lauenroth, Andreas; Coughlin, Joseph F

2017-01-01

The "Age Suit" described in this article was developed to enable future designers, business leaders, and engineers to experience navigating the world as many older adults must. Tools such as this Age Suit offer the opportunity to "walk a mile" in another's shoes to develop empathy that can result in better design of spaces, goods, and services to meet the needs of a rapidly growing older population. This work first examined, through a series of clinical tests, whether younger adults' physical capacities were reduced in a direction consistent with aging by wearing a suit developed by the MIT AgeLab. An experiential learning task was then completed with the suit to understand its impact on completion of an instrumental activity of daily living. Results showed that younger adults wearing the suit experienced changes in task performance consistent with expected changes associated with aging. Participants' self-reports from the experiential learning task indicated that they were able to empathize with older adults regarding some issues they face while completing a grocery shopping task. Future research with the suit should involve a wider range of individuals from the population and examine what effect participants' levels of fitness have on the experience of wearing the suit.

First-ever evening public engine test of a Space Shuttle Main Engine

NASA Image and Video Library

2001-04-21

Thousands of people watch the first-ever evening public engine test of a Space Shuttle Main Engine at NASA's John C. Stennis Space Center. The spectacular test marked Stennis Space Center's 20th anniversary celebration of the first Space Shuttle mission.

NASA Science Review of Next Planet-Hunting Mission Launch

NASA Image and Video Library

2018-04-15

NASA and science investigators from MIT participate in a science briefing for the agency's Transiting Exoplanet Survey Satellite (TESS) in the Press Site auditorium at Kennedy Space Center in Florida. From left are moderator Claire Saravia, NASA Communications; Paul Hertz, Astrophysics Division director, NASA Headquarters; George Ricker, TESS principal investigator, Massachusetts Institute of Technology; Padi Boyd, TESS Guest Investigator Program lead, NASA’s Goddard Space Flight Center; Stephen Rinehart, TESS Project scientist, NASA’s Goddard Space Flight Center; and Diana Dragomir, NASA Hubble Postdoctoral Fellow, Massachusetts Institute of Technology. TESS is the next step in the search for planets outside of our solar system. The mission will find exoplanets that periodically block part of the light from their host stars, events called transits. The satellite will survey the nearest and brightest stars for two years to search for transiting exoplanets. TESS will launch on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station no earlier than 6:32 p.m. EDT on Monday, April 16.

Knocking down mitochondrial iron transporter (MIT) reprograms primary and secondary metabolism in rice plants

PubMed Central

Vigani, Gianpiero; Bashir, Khurram; Ishimaru, Yasuhiro; Lehmann, Martin; Casiraghi, Fabio Marco; Nakanishi, Hiromi; Seki, Motoaki; Geigenberger, Peter; Zocchi, Graziano; Nishizawa, Naoko K.

2016-01-01

Iron (Fe) is an essential micronutrient for plant growth and development, and its reduced bioavailability strongly impairs mitochondrial functionality. In this work, the metabolic adjustment in the rice (Oryza sativa) mitochondrial Fe transporter knockdown mutant (mit-2) was analysed. Biochemical characterization of purified mitochondria from rice roots showed alteration in the respiratory chain of mit-2 compared with wild-type (WT) plants. In particular, proteins belonging to the type II alternative NAD(P)H dehydrogenases accumulated strongly in mit-2 plants, indicating that alternative pathways were activated to keep the respiratory chain working. Additionally, large-scale changes in the transcriptome and metabolome were observed in mit-2 rice plants. In particular, a strong alteration (up-/down-regulation) in the expression of genes encoding enzymes of both primary and secondary metabolism was found in mutant plants. This was reflected by changes in the metabolic profiles in both roots and shoots of mit-2 plants. Significant alterations in the levels of amino acids belonging to the aspartic acid-related pathways (aspartic acid, lysine, and threonine in roots, and aspartic acid and ornithine in shoots) were found that are strictly connected to the Krebs cycle. Furthermore, some metabolites (e.g. pyruvic acid, fumaric acid, ornithine, and oligosaccharides of the raffinose family) accumulated only in the shoot of mit-2 plants, indicating possible hypoxic responses. These findings suggest that the induction of local Fe deficiency in the mitochondrial compartment of mit-2 plants differentially affects the transcript as well as the metabolic profiles in root and shoot tissues. PMID:26685186

Combining ergometer exercise and artificial gravity in a compact-radius centrifuge

NASA Astrophysics Data System (ADS)

Diaz, Ana; Trigg, Chris; Young, Laurence R.

2015-08-01

Humans experience physiological deconditioning during space missions, primarily attributable to weightlessness. Some of these adverse consequences include bone loss, muscle atrophy, sensory-motor deconditioning, and cardiovascular alteration, which may lead to orthostatic intolerance when astronauts return to Earth. Artificial gravity could provide a comprehensive countermeasure capable of challenging all the physiological systems at once, particularly if combined with exercise, thereby maintaining overall health during extended exposure to weightlessness. A new Compact Radius Centrifuge (CRC) platform was designed and built on the existing Short Radius Centrifuge (SRC) at the Massachusetts Institute of Technology (MIT). The centrifuge has been constrained to a radius of 1.4 m, the upper radial limit for a centrifuge to fit within an International Space Station (ISS) module without extensive structural alterations. In addition, a cycle ergometer has been added for exercise during centrifugation. The CRC now includes sensors of foot forces, cardiovascular parameters, and leg muscle electromyography. An initial human experiment was conducted on 12 subjects to analyze the effects of different artificial gravity levels (0 g, 1 g, and 1.4 g, measured at the feet) and ergometer exercise intensities (25 W warm-up, 50 W moderate and 100 W vigorous) on the musculoskeletal function as well as motion sickness and comfort. Foot forces were measured during the centrifuge runs, and subjective comfort and motion sickness data were gathered after each session. Preliminary results indicate that ergometer exercise on a centrifuge may be effective in improving musculoskeletal function. The combination is well tolerated and motion sickness is minimal. The MIT CRC is a novel platform for future studies of exercise combined with artificial gravity. This combination may be effective as a countermeasure to space physiological deconditioning.

SpaceX TESS Fairing Move

NASA Image and Video Library

2018-04-03

The payload fairing for NASA's Transiting Exoplanet Survey Satellite (TESS) is moved to the entrance of the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. Inside the facility, TESS will be encapsulated in the payload fairing. The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

SpaceX TESS Fairing Move

NASA Image and Video Library

2018-04-03

The payload fairing for NASA's Transiting Exoplanet Survey Satellite (TESS) is being prepared for the move to the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. Inside the facility, TESS will be encapsulated in the payload fairing. The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS SpaceX Payload Fairing Move to PHSF

NASA Image and Video Library

2018-04-03

The payload fairing for NASA's Transiting Exoplanet Survey Satellite (TESS) is moved to the entrance of the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. Inside the facility, TESS will be encapsulated in the payload fairing. The satellite is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS-Transport to Pad Activities - Lift to Transport Trailer

NASA Image and Video Library

2018-04-11

Inside the Payload Hazardous Servicing Facility at NASA's Kennedy Space Center in Florida, the SpaceX payload fairing containing the agency's Transiting Exoplanet Survey Satellite (TESS) is secured onto a transporter. The fairing will be moved to Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is scheduled to launch on the SpaceX Falcon 9 rocket at 6:32 p.m. EDT on April 16. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

Scratch that: MIT's Mitchel Resnick Says Kids Should Do It for Themselves

ERIC Educational Resources Information Center

Traylor, Scott

2008-01-01

Mitchel Resnick is a researcher, inventor, and professor at MIT's Media Laboratory in Cambridge, MA, and the founder of the Lifelong Kindergarten Group at MIT. He is the lead innovator behind many cutting-edge learning technologies and projects for children, including the Computer Clubhouse, PicoCrickets, and the wildly successful consumer…

Mobile-IT Education (MIT.EDU): M-Learning Applications for Classroom Settings

ERIC Educational Resources Information Center

Sung, M.; Gips, J.; Eagle, N.; Madan, A.; Caneel, R.; DeVaul, R.; Bonsen, J.; Pentland, A.

2005-01-01

In this paper, we describe the Mobile-IT Education (MIT.EDU) system, which demonstrates the potential of using a distributed mobile device architecture for rapid prototyping of wireless mobile multi-user applications for use in classroom settings. MIT.EDU is a stable, accessible system that combines inexpensive, commodity hardware, a flexible…

Coming to Terms with MOOCs: A Community College Angle

ERIC Educational Resources Information Center

Fifield, Mary L.

2013-01-01

When MIT approached Bunker Hill Community College (BHCC) to participate in edX, the new Harvard/MIT massive open online course (MOOC) initiative, the administrators reacted with both interest and skepticism. What did MIT have in mind for Bunker Hill Community College? Today at BHCC, the establishment of "Learning Communities" transforms…

MND2: A new mouse model of inherited motor neuron disease

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, J.M.; Albin, R.L.; Feldman, E.L.

1993-06-01

The autosomal recessive mutation mnd2 results in early onset motor neuron disease with rapidly progressive paralysis, severe muscle wasting, regression of thymus and spleen, and death before 40 days of age. mnd2 has been mapped to mouse chromosome 6 with the gene order: centromere-Tcrb-Ly-2-Sftp-3-D6Mit4-mnd2-D6Mit6, D6Mit9-D6Rck132-Raf-1, D6Mit11-D6Mit12-D6Mit14. mnd2 is located within a conserved linkage group with homologs on human chromosome 2p12-p13. Spinal motor neurons of homozygous affected animals are swollen and stain weakly, and electromyography revealed spontaneous activity characteristic of muscle denervation. Myelin staining was normal throughout the neuraxis. The clinical observations are consistent with a primary abnormality of lower motormore » neuron function. This new animal model will be of value for identification of a genetic defect responsible for motor neuron disease and for evaluation of new therapies. 36 refs., 7 figs., 2 tabs.« less

Digital Transformation Canvas - Übersicht behalten und Handlungsfelder gestalten

NASA Astrophysics Data System (ADS)

Köster, Michael; Mache, Tobias

Im Beitrag "Digital Transformation Canvas - Übersicht behalten und Handlungsfelder gestalten" wird zunächst grob auf die wesentlichen Herausforderungen, die mit der zunehmenden Digitalisierung einhergehen, eingegangen. Anschließend werden ausgewählte Konzepte des Business Transformation Management vorgestellt, die sich mit der grundlegenden Weiterentwicklung von Organisationen - wie es die Digitalisierung erfordert - auseinandersetzen. Eine detaillierte Einführung in die Methodik des Business Transformation Canvas, der sich mit den unterschiedlichsten Gestaltungsfeldern der Transformation auseinandersetzt und ein Framework für Transformationsprojekte darstellt, rundet den Beitrag ab. Er schließt mit einem Fazit und Ausblick.

Stennis certifies final shuttle engine

NASA Image and Video Library

2008-10-22

Steam blasts out of the A-2 Test Stand at Stennis Space Center on Oct. 22 as engineers begin a certification test on engine 2061, the last space shuttle main flight engine scheduled to be built. Since 1975, Stennis has tested every space shuttle main engine used in the program - about 50 engines in all. Those engines have powered more than 120 shuttle missions - and no mission has failed as a result of engine malfunction. For the remainder of 2008 and throughout 2009, Stennis will continue testing of various space shuttle main engine components.

General view of a Space Shuttle Main Engine (SSME) mounted ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General view of a Space Shuttle Main Engine (SSME) mounted on an SSME engine handler, taken in the SSME Processing Facility at Kennedy Space Center. The most prominent features of the engine assembly in this view are the Low-Pressure Oxidizer Turbopump Discharge Duct looping around the right side of the engine assembly then turning in and connecting to the High-Pressure Oxidizer Turbopump. The sphere in the approximate center of the assembly is the POGO System Accumulator, the Engine Controller is located on the bottom and slightly left of the center of the Engine Assembly in this view. - Space Transportation System, Space Shuttle Main Engine, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy

PubMed Central

Zhao, Yiqiao; Yu, Hua; Zhou, Haiyu; Chen, Meiwan

2017-01-01

Mitoxantrone (MIT) is an anticancer agent with photosensitive properties that is commonly used in various cancers. Multidrug resistance (MDR) effect has been an obstacle to using MIT for cancer therapy. Photochemical internalization, on account of photodynamic therapy, has been applied to improve the therapeutic effect of cancers with MDR effect. In this study, an MIT-poly(ε-caprolactone)-pluronic F68-poly(ε-caprolactone)/poly(d,l-lactide-co-glycolide)–poly(ethylene glycol)–poly(d,l-lactide-co-glycolide) (MIT-PFP/PPP) mixed micelles system was applied to reverse the effect of MDR in MCF-7/ADR cells via photochemical reaction when exposed to near-infrared light. MIT-PFP/PPP mixed micelles showed effective interaction with near-infrared light at the wavelength of 660 nm and exerted great cytotoxicity in MCF-7/ADR cells with irradiation. Furthermore, MIT-PFP/PPP mixed micelles could improve reactive oxygen species (ROS) levels, decrease P-glycoprotein activity, and increase the cellular uptake of drugs with improved intracellular drug concentrations, which induced cell apoptosis in MCF-7/ADR cells under irradiation, despite MDR effect, as indicated by the increased level of cleaved poly ADP-ribose polymerase. These findings suggested that MIT-PFP/PPP mixed micelles may become a promising strategy to effectively reverse the MDR effect via photodynamic therapy in breast cancer. PMID:28919756

Dynamics of the metal-insulator transition of donor-doped SrTi O3

NASA Astrophysics Data System (ADS)

Meyer, René; Zurhelle, Alexander F.; De Souza, Roger A.; Waser, Rainer; Gunkel, Felix

2016-09-01

The electrical properties of donor-doped SrTi O3 (n -STO) are profoundly affected by an oxidation-induced metal-insulator transition (MIT). Here we employ dynamical numerical simulations to examine the high-temperature MIT of n -STO over a large range of time and length scales. The simulations are based on the Nernst-Planck equations, the continuity equations, and the Poisson equation, in combination with surface lattice disorder equilibria serving as time-dependent boundary conditions. The simulations reveal that n -STO, upon oxidation, develops a kinetic space charge region (SCR) in the near-surface region. The surface concentrations of the variously mobile defects (electrons, Sr vacancies, and O vacancies) are found to vary over time and to differ considerably from the values of the new equilibrium. The formation of the SCR in which electrons are strongly depleted occurs within nanoseconds, i.e., it yields a fast MIT in the near-surface region during the oxidation process. As a result of charge (over-)compensation by Sr vacancies incorporated at the surface of n -STO, this SCR is much more pronounced than conventionally expected. In addition, we find an anomalous increase of O vacancy concentration at the surface upon oxidation caused by the SCR. Our simulations show that the SCR fades in the long term as a result of the slow in-diffusion of Sr vacancies. We discuss implications for the electrical conductivity of n -STO crystals used as substrates for epitaxial oxide thin films, of n -STO thin films and interfaces, and of polycrystalline n -STO with various functionalities.

The Fourteenth International Meeting on Time-Resolved Vibrational Spectroscopy (TRVS XIV)

DTIC Science & Technology

2010-02-03

Technology United States ahorning@mit.edu Anne Hudson MIT Dept. of Chemistry United States amh@mit.edu Adriana Huerta Viga University of Amsterdam...Hoffmann, Janos Hebling, Harold Y. Hwang, THz-pump/THz-probe nonlinear spectroscopy Ka -Lo Yeh, Keith A. Nelson, MIT 11:30 AM C Tomonori Nomoto and

The OpenCourseWare Story: New England Roots, Global Reach

ERIC Educational Resources Information Center

Carson, Stephen

2008-01-01

The OpenCourseWare movement has its roots in New England. The concept emerged in 2000 at Massachusetts Institute of Technology (MIT) where then-President Charles Vest charged a faculty committee with answering two questions: "How is the Internet going to change education?" and "What should MIT do about it?" MIT moved quickly to…

Dhaksha, the Unmanned Aircraft System in its New Avatar-Automated Aerial Inspection of INDIA'S Tallest Tower

NASA Astrophysics Data System (ADS)

Kumar, K. S.; Rasheed, A. Mohamed; Krishna Kumar, R.; Giridharan, M.; Ganesh

2013-08-01

DHAKSHA, the unmanned aircraft system (UAS), developed after several years of research by Division of Avionics, Department of Aerospace Engineering, MIT Campus of Anna University has recently proved its capabilities during May 2012 Technology demonstration called UAVforge organised by Defence Research Project Agency, Department of Defence, USA. Team Dhaksha with its most stable design outperformed all the other contestants competing against some of the best engineers from prestigi ous institutions across the globe like Middlesex University from UK, NTU and NUS from Singapore, Tudelft Technical University, Netherlands and other UAV industry participants in the world's toughest UAV challenge. This has opened up an opportunity for Indian UAVs making a presence in the international scenario as well. In furtherance to the above effort at Fort Stewart military base at Georgia,USA, with suitable payloads, the Dhaksha team deployed the UAV in a religious temple festival during November 2012 at Thiruvannamalai District for Tamil Nadu Police to avail the instant aerial imagery services over the crowd of 10 lakhs pilgrims and also about the investigation of the structural strength of the India's tallest structure, the 300 m RCC tower during January 2013. The developed system consists of a custom-built Rotary Wing model with on-board navigation, guidance and control systems (NGC) and ground control station (GCS), for mission planning, remote access, manual overrides and imagery related computations. The mission is to fulfill the competition requirements by using an UAS capable of providing complete solution for the stated problem. In this work the effort to produce multirotor unmanned aerial systems (UAS) for civilian applications at the MIT, Avionics Laboratory is presented

Prospective pilot trial of PerMIT versus standard anticoagulation service management of patients initiating oral anticoagulation.

PubMed

Borgman, Mark P; Pendleton, Robert C; McMillin, Gwendolyn A; Reynolds, Kristen K; Vazquez, Sara; Freeman, Andrew; Wilson, Andrew; Valdes, Roland; Linder, Mark W

2012-09-01

We performed a randomised pilot trial of PerMIT, a novel decision support tool for genotype-based warfarin initiation and maintenance dosing, to assess its efficacy for improving warfarin management. We prospectively studied 26 subjects to compare PerMIT-guided management with routine anticoagulation service management. CYP2C9 and VKORC1 genotype results for 13 subjects randomly assigned to the PerMIT arm were recorded within 24 hours of enrolment. To aid in INR interpretation, PerMIT calculates estimated loading and maintenance doses based on a patient's genetic and clinical characteristics and displays calculated S-warfarin plasma concentrations based on planned or administered dosages. In comparison to control subjects, patients in the PerMIT study arm demonstrated a 3.6-day decrease in the time to reach a stabilised INR within the target therapeutic range (4.7 vs. 8.3 days, p = 0.015); a 12.8% increase in time spent within the therapeutic interval over the first 25 days of therapy (64.3% vs. 55.3%, p = 0.180); and a 32.9% decrease in the frequency of warfarin dose adjustments per INR measurement (38.3% vs. 57.1%, p = 0.007). Serial measurements of plasma S-warfarin concentrations were also obtained to prospectively evaluate the accuracy of the pharmacokinetic model during induction therapy. The PerMIT S-warfarin plasma concentration model estimated 62.8% of concentrations within 0.15 mg/l. These pilot data suggest that the PerMIT method and its incorporation of genotype/phenotype information may help practitioners increase the safety, efficacy, and efficiency of warfarin therapeutic management.

Knocking down mitochondrial iron transporter (MIT) reprograms primary and secondary metabolism in rice plants.

PubMed

Vigani, Gianpiero; Bashir, Khurram; Ishimaru, Yasuhiro; Lehmann, Martin; Casiraghi, Fabio Marco; Nakanishi, Hiromi; Seki, Motoaki; Geigenberger, Peter; Zocchi, Graziano; Nishizawa, Naoko K

2016-03-01

Iron (Fe) is an essential micronutrient for plant growth and development, and its reduced bioavailability strongly impairs mitochondrial functionality. In this work, the metabolic adjustment in the rice (Oryza sativa) mitochondrial Fe transporter knockdown mutant (mit-2) was analysed. Biochemical characterization of purified mitochondria from rice roots showed alteration in the respiratory chain of mit-2 compared with wild-type (WT) plants. In particular, proteins belonging to the type II alternative NAD(P)H dehydrogenases accumulated strongly in mit-2 plants, indicating that alternative pathways were activated to keep the respiratory chain working. Additionally, large-scale changes in the transcriptome and metabolome were observed in mit-2 rice plants. In particular, a strong alteration (up-/down-regulation) in the expression of genes encoding enzymes of both primary and secondary metabolism was found in mutant plants. This was reflected by changes in the metabolic profiles in both roots and shoots of mit-2 plants. Significant alterations in the levels of amino acids belonging to the aspartic acid-related pathways (aspartic acid, lysine, and threonine in roots, and aspartic acid and ornithine in shoots) were found that are strictly connected to the Krebs cycle. Furthermore, some metabolites (e.g. pyruvic acid, fumaric acid, ornithine, and oligosaccharides of the raffinose family) accumulated only in the shoot of mit-2 plants, indicating possible hypoxic responses. These findings suggest that the induction of local Fe deficiency in the mitochondrial compartment of mit-2 plants differentially affects the transcript as well as the metabolic profiles in root and shoot tissues. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.

Mechanisms of spin-flipping and metal-insulator transition in nano-Fe3O4

NASA Astrophysics Data System (ADS)

Dito Fauzi, Angga; Aziz Majidi, Muhammad; Rusydi, Andrivo

2017-04-01

Fe3O4 is a half-metallic ferrimagnet with {{T}\\text{C}}˜ 860 K exhibiting metal-insulator transition (MIT) at  ˜120 K. In bulk form, the saturation magnetization is 0.6 Tesla (˜471 emu cm-3). A recent experimental study has shown that the saturation magnetization of nano-Fe3O4 thin films can achieve up to  ˜760 emu cm-3, attributed to spin-flipping of Fe ions at tetrahedral sites assisted by oxygen vacancies (V O). Such a system has shown to have higher MIT temperature (˜150 K). The spin-flipping is a new phenomenon in Fe3O4, while the MIT is a long-standing one. Here, we propose a model and calculations to investigate the mechanisms of both phenomena. Our results show that, for the system without V O, the ferrimagnetic configuration is energetically favorable. Remakably, upon inclusion of V O, the ground-state configuration switches into ferromagnetic. As for the MIT, by proposing temperature dependences of some hopping integrals in the model, we demonstrate that the system without and with V O undergo the MIT in slightly different ways, leading to higher MIT temperature for the system with V O, in agreement with the experimental data. Our results also show that the MIT in both systems occur concomitantly with the redistribution of electrons among the three Fe ions in each Fe3O4 formula unit. As such temperature dependences of hopping integrals may arise due to dynamic Jahn-Teller effects, our phenomenological theory may provide a way to reconcile existing theories relating the MIT to the structural transition and the charge ordering.

Leadership in Space: Selected Speeches of NASA Administrator Michael Griffin, May 2005 - October 2008

NASA Technical Reports Server (NTRS)

Griffin, Michael

2008-01-01

Speech topics include: Leadership in Space; Space Exploration: Real and Acceptable Reasons; Why Explore Space?; Space Exploration: Filling up the Canvas; Continuing the Voyage: The Spirit of Endeavour; Incorporating Space into Our Economic Sphere of Influence; The Role of Space Exploration in the Global Economy; Partnership in Space Activities; International Space Cooperation; National Strategy and the Civil Space Program; What the Hubble Space Telescope Teaches Us about Ourselves; The Rocket Team; NASA's Direction; Science and NASA; Science Priorities and Program Management; NASA and the Commercial Space Industry; NASA and the Business of Space; American Competitiveness: NASA's Role & Everyone's Responsibility; Space Exploration: A Frontier for American Collaboration; The Next Generation of Engineers; System Engineering and the "Two Cultures" of Engineering; Generalship of Engineering; NASA and Engineering Integrity; The Constellation Architecture; Then and Now: Fifty Years in Space; The Reality of Tomorrow; and Human Space Exploration: The Next 50 Years.

Finite mass enhancement across bandwidth controlled Mott transition in NiS2-xSex

NASA Astrophysics Data System (ADS)

Han, Garam; Kyung, W. S.; Kim, Y. K.; Cheng, C. M.; Tsuei, K. D.; Lee, K. D.; Hur, N.; Kim, H.-D.; Kim, C.

One of the most important and still debated issues in the strongly correlated electron systems is on the metal insulator transition (MIT) mechanism. In the bandwidth controlled Mott transition (BCMT) scenario, which Mott originally proposed, MIT occurs through a mass divergence in which the effective mass of the quasi-particle (QP) diverges approaching the MIT. The interpretation is supported by dynamic mean field theory (DMFT) model calculations. However, few direct observations have been made yet due to various experimental restrictions. In this talk, I present systematic angle resolved photoemission studies on the MIT in NiS2-xSex, which is a well-known BCMT material. We observed not only the bandwidth shrinkage but also the coherent quasi-particle peak (QP) which is not of the surface origin. In addition, we experimentally showed the mass of the QP remains finite approaching the MIT. This work was supported by IBS-R009-D1.

ZAP! Adapted: Incorporating design in the introductory electromagnetism lab

NASA Astrophysics Data System (ADS)

McNeil, J. A.

2002-04-01

In the last decade the Accreditation Board of Engineering and Technology(ABET) significantly reformed the criteria by which engineering programs are accredited. The new criteria are called Engineering Criteria 2000 (EC2000). Not surprisingly, engineering design constitutes an essential component of these criteria. The Engineering Physics program at the Colorado School of Mines (CSM) underwent an ABET general review and site visit in the fall of 2000. In preparation for this review and as part of a campus-wide curriculum reform the Physics Department was challenged to include elements of design in its introductory laboratories. As part of the background research for this reform, several laboratory programs were reviewed including traditional and studio modes as well as a course used by Cal Tech and MIT called "ZAP!" which incorporates design activities well-aligned with the EC2000 criteria but in a nontraditional delivery mode. CSM has adapted several ZAP! experiments to a traditional laboratory format while attempting to preserve significant design experiences. The new laboratory forms an important component of the reformed course which attempts to respect the psychological principles of learner-based education. This talk reviews the reformed introductory electromagnetism course and how the laboratories are integrated into the pedagogy along with design activities. In their new form the laboratories can be readily adopted by physics departments using traditional delivery formats.

Space engine safety system

NASA Technical Reports Server (NTRS)

Maul, William A.; Meyer, Claudia M.

1991-01-01

A rocket engine safety system was designed to initiate control procedures to minimize damage to the engine or vehicle or test stand in the event of an engine failure. The features and the implementation issues associated with rocket engine safety systems are discussed, as well as the specific concerns of safety systems applied to a space-based engine and long duration space missions. Examples of safety system features and architectures are given, based on recent safety monitoring investigations conducted for the Space Shuttle Main Engine and for future liquid rocket engines. Also, the general design and implementation process for rocket engine safety systems is presented.

Free-piston Stirling technology for space power

NASA Technical Reports Server (NTRS)

Slaby, Jack G.

1989-01-01

An overview is presented of the NASA Lewis Research Center free-piston Stirling engine activities directed toward space power. This work is being carried out under NASA's new Civil Space Technology Initiative (CSTI). The overall goal of CSTI's High Capacity Power element is to develop the technology base needed to meet the long duration, high capacity power requirements for future NASA space missions. The Stirling cycle offers an attractive power conversion concept for space power needs. Discussed here is the completion of the Space Power Demonstrator Engine (SPDE) testing-culminating in the generation of 25 kW of engine power from a dynamically-balanced opposed-piston Stirling engine at a temperature ratio of 2.0. Engine efficiency was approximately 22 percent. The SPDE recently has been divided into two separate single-cylinder engines, called Space Power Research Engine (SPRE), that now serve as test beds for the evaluation of key technology disciplines. These disciplines include hydrodynamic gas bearings, high-efficiency linear alternators, space qualified heat pipe heat exchangers, oscillating flow code validation, and engine loss understanding.

TESS Spacecraft Lift to Work Stand

NASA Image and Video Library

2018-02-12

Technicians dressed in clean room suits monitor the progress as a crane lowers NASA's Transiting Exoplanet Survey Satellite (TESS) onto a test stand inside the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS: Spacecraft Arrival

NASA Image and Video Library

2018-02-13

In the Payload Hazardous Servicing Facility at NASA's Kennedy Space Center in Florida, the agency's Transiting Exoplanet Survey Satellite, or TESS, has been uncreated from its shipping container for inspections and preflight processing. The satellite is NASA's next step in the search for planets outside of the solar system also known as "exoplanets." TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, and the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management. SpaceX of Hawthorne, California, is the provider of the Falcon 9 launch service. TESS is scheduled to launch atop a Falcon 9 rocket no earlier than April 16, 2018 from Space Launch Complex 41 at Cape Canaveral Air Force Station.

TESS Spacecraft Move to Clean Room

NASA Image and Video Library

2018-02-12

NASA's Transiting Exoplanet Survey Satellite (TESS), secured on a test stand, is moved into a clean room tent inside the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Lift to Work Stand

NASA Image and Video Library

2018-02-12

NASA's Transiting Exoplanet Survey Satellite (TESS) is lifted up from the base of its shipping container and will be lowered onto a test stand for processing inside the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Solar Panel Array Deployment Testing

NASA Image and Video Library

2018-02-21

Technicians dressed in clean room suits monitor the progress as both solar panels are deployed on NASA's Transiting Exoplanet Survey Satellite (TESS) inside the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite is being processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Move to Clean Room

NASA Image and Video Library

2018-02-12

Technician dressed in clean room suits move NASA's Transiting Exoplanet Survey Satellite (TESS) on a test stand to a clean room tent inside the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Solar Panel Array Deployment Testing

NASA Image and Video Library

2018-02-21

Technicians dressed in clean room suits check the solar panels, which have been deployed, on NASA's Transiting Exoplanet Survey Satellite (TESS) inside the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite is being processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. The satellite is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Move to Clean Room

NASA Image and Video Library

2018-02-12

Technicians dressed in clean room suits move NASA's Transiting Exoplanet Survey Satellite (TESS) on a test stand inside the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Move to Clean Room

NASA Image and Video Library

2018-02-12

Technicians dressed in clean room suits move NASA's Transiting Exoplanet Survey Satellite (TESS) secured on a test stand inside the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Uncrating

NASA Image and Video Library

2018-02-12

The top of the shipping container is lifted up by crane from NASA's Transiting Exoplanet Survey Satellite (TESS) inside the Payload Hazardous Servicing Facility at the agency's Kennedy Space Center in Florida. TESS will be unpacked, lifted up by crane and moved to a test stand for processing. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Move to Clean Room

NASA Image and Video Library

2018-02-12

Technician dressed in clean room suits move NASA's Transiting Exoplanet Survey Satellite (TESS) on a test stand into a clean room tent inside the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

TESS Spacecraft Lift to Work Stand

NASA Image and Video Library

2018-02-12

A technician dressed in a clean room suit closely monitors the progress as a crane lowers NASA's Transiting Exoplanet Survey Satellite (TESS) onto a test stand inside the Payload Hazardous Servicing Facility (PHSF) at the agency's Kennedy Space Center in Florida. Inside the PHSF, the satellite will be processed and prepared for its flight. TESS is scheduled to launch atop a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Air Force Station. TESS is the next step in NASA's search for planets outside our solar system, known as exoplanets. TESS is a NASA Astrophysics Explorer mission led and operated by MIT in Cambridge, Massachusetts, and managed by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. Dr. George Ricker of MIT’s Kavli Institute for Astrophysics and Space Research serves as principal investigator for the mission. Additional partners include Orbital ATK, NASA’s Ames Research Center, the Harvard-Smithsonian Center for Astrophysics and the Space Telescope Science Institute. More than a dozen universities, research institutes and observatories worldwide are participants in the mission. NASA’s Launch Services Program is responsible for launch management.

Hide and Seek: Exploiting and Hardening Leakage-Resilient Code Randomization

DTIC Science & Technology

2016-05-30

Hide and Seek: Exploiting and Hardening Leakage -Resilient Code Randomization Robert Rudd MIT Lincoln Laboratory Thomas Hobson MIT Lincoln Laboratory...Irvine Ahmad-Reza Sadeghi TU Darmstadt Hamed Okhravi MIT Lincoln Laboratory Abstract Information leakage vulnerabilities can allow adversaries to...bypass mitigations based on code randomization. This discovery motivates numerous techniques that diminish direct and indirect information leakage : (i

Hide and Seek: Exploiting and Hardening Leakage-Resilient Code Randomization

DTIC Science & Technology

2016-03-30

Hide and Seek: Exploiting and Hardening Leakage -Resilient Code Randomization Robert Rudd MIT Lincoln Laboratory Thomas Hobson MIT Lincoln Laboratory...Irvine Ahmad-Reza Sadeghi TU Darmstadt Hamed Okhravi MIT Lincoln Laboratory Abstract Information leakage vulnerabilities can allow adversaries to...bypass mitigations based on code randomization. This discovery motivates numerous techniques that diminish direct and indirect information leakage : (i

Data Driven Change Is Easy; Assessing and Maintaining It Is the Hard Part

ERIC Educational Resources Information Center

Perelman, Les

2009-01-01

At MIT in the 1990's, data from two sources, a study of the writing ability of a small group of randomly selected MIT juniors correlated to their overall academic performance and a survey of alumni from various years provided the major motivation for the development by MIT faculty and administration of a very ambitious…

Teaching Heliophysics Science to Undergraduates in an Engineering Context

NASA Astrophysics Data System (ADS)

Baker, J. B.; Sweeney, D. G.; Ruohoniemi, J.

2013-12-01

In recent years, space research at Virginia Tech has experienced rapid growth since the initiation of the Center for Space Science and Engineering Research (Space@VT) during the summer of 2007. The Space@VT center resides in the College of Engineering and currently comprises approximately 30-40 faculty and students. Space@VT research encompasses a wide spectrum of science and engineering activities including: magnetosphere-ionosphere data analysis; ground- and space-based instrument development; spacecraft design and environmental interactions; and numerical space plasma simulations. In this presentation, we describe how Space@VT research is being integrated into the Virginia Tech undergraduate engineering curriculum via classroom instruction and hands-on group project work. In particular, we describe our experiences teaching a new sophomore course titled 'Exploration of the Space Environment' which covers a broad range of scientific, engineering, and societal aspects associated with the exploration and technological exploitation of space. Topics covered include: science of the space environment; space weather hazards and societal impacts; elementary orbital mechanics and rocket propulsion; spacecraft engineering subsystems; and applications of space-based technologies. We also describe a high-altitude weather balloon project which has been offered as a 'hands-on' option for fulfilling the course project requirements of the course.

ARPES studies on metal-insulator-transition in NiS2-xSex

NASA Astrophysics Data System (ADS)

Han, Garam; Kim, Y. K.; Kyung, W. S.; Kim, Chul; Koh, Y. Y.; Lee, K. D.; Kim, C.

2012-02-01

Understanding Metal insulator transition (MIT) is one of the most challenging issues in condensed matter physics. NiS2-xSex (NSS) is a well known system for band width controlled MIT studies while most of High-Tc superconductors (HTSCs) are described within band filling MIT picture. Cubic pyrite NiS2 is known as a charge-transfer (CT) insulator and easily forms a solid solution with NiSe2, which is a good metal even though it is isostrucural and isoelectronic to NiS2. MIT is induced by Se alloying and is observed at a low temperature for x=0.5. The important merit is that there is no structure transition which often accompanies MIT. In spite of the importance of the system, even the experimental band dispersion is not known so far along with many controversies. For this reason, we performed angle resolved photoemission spectroscopy on high quality single crystals and successfully obtained Fermi surface maps of x=0.5, x=0.7 and x=0.8 systems (the metallic side). By doping dependent systematic studies on NSS and comparison with LDA calculation, we try to explain the relationship between band width and the MIT.

Magnetically driven metal-insulator transition in NaOsO3

NASA Astrophysics Data System (ADS)

Calder, Stuart

2013-03-01

The metal-insulator transition (MIT) is one of the most dramatic manifestations of electron correlations in materials, enjoying interest both for its fundamental nature and technological application. Various mechanisms producing MITs have been extensively considered over the years, including the Mott (electron localization via Coulomb repulsion), Anderson (localization via disorder) and Peierls (localization via distortion of a periodic one-dimensional lattice). One additional route to a MIT proposed by Slater in 1951, in which long-range magnetic order in a three dimensional system drives the MIT, has received relatively little attention, particularly from an experimental viewpoint. Using neutron and x-ray scattering we have shown that the MIT in NaOsO3 is coincident with the onset of long-range commensurate magnetic order at 410 K. Whilst candidate materials have been suggested, our experimental methodology allows the first definitive demonstration of the long predicted Slater MIT. We discuss our results in light of recent work on other 5d systems that contrastingly have been predicted to host a Mott spin-orbit insulating state. Work was supported by the Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy (DOE).

Closeup View of the Space Shuttle Main Engine (SSME) 2044 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Close-up View of the Space Shuttle Main Engine (SSME) 2044 mounted in a SSME Engine Handler in the SSME processing Facility at Kennedy Space Center. This view shows SSME 2044 with its expansion nozzle removed and an Engine Leak-Test Plug is set in the throat of the Main Combustion Chamber in the approximate center of the image, the insulated, High-Pressure Fuel Turbopump sits below that and the Low Pressure Oxidizer Turbopump Discharge Duct sits towards the top of the engine assembly in this view. - Space Transportation System, Space Shuttle Main Engine, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

GaN Initiative for Grid Applications (GIGA)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turner, George

2015-07-03

For nearly 4 ½ years, MIT Lincoln Laboratory (MIT/LL) led a very successful, DoE-funded team effort to develop GaN-on-Si materials and devices, targeting high-voltage (>1 kV), high-power, cost-effective electronics for grid applications. This effort, called the GaN Initiative for Grid Applications (GIGA) program, was initially made up of MIT/LL, the MIT campus group of Prof. Tomas Palacios (MIT), and the industrial partner M/A Com Technology Solutions (MTS). Later in the program a 4th team member was added (IQE MA) to provide commercial-scale GaN-on-Si epitaxial materials. A basic premise of the GIGA program was that power electronics, for ubiquitous utilization -evenmore » for grid applications - should be closer in cost structure to more conventional Si-based power electronics. For a number of reasons, more established GaN-on-SiC or even SiC-based power electronics are not likely to reach theses cost structures, even in higher manufacturing volumes. An additional premise of the GIGA program was that the technical focus would be on materials and devices suitable for operating at voltages > 1 kV, even though there is also significant commercial interest in developing lower voltage (< 1 kV), cost effective GaN-on-Si devices for higher volume applications, like consumer products. Remarkable technical progress was made during the course of this program. Advances in materials included the growth of high-quality, crack-free epitaxial GaN layers on large-diameter Si substrates with thicknesses up to ~5 μm, overcoming significant challenges in lattice mismatch and thermal expansion differences between Si and GaN in the actual epitaxial growth process. Such thick epilayers are crucial for high voltage operation of lateral geometry devices such as Schottky barrier (SB) diodes and high electron mobility transistors (HEMTs). New “Normally-Off” device architectures were demonstrated – for safe operation of power electronics circuits. The trade-offs between lateral and vertical devices were explored, with the conclusion that lateral devices are superior for fundamental thermal reasons, as well as for the demonstration of future generations of monolithic power circuits. As part of the materials and device investigations breakdown mechanisms in GaN-on-Si structures were fully characterized and effective electric field engineering was recognized as critical for achieving even higher voltage operation. Improved device contact technology was demonstrated, including the first gold-free metallizations (to enable processing in CMOS foundries) while maintaining low specific contact resistance needed for high-power operation and 5-order-of magnitude improvement in device leakage currents (essential for high power operation). In addition, initial GaN-on-Si epitaxial growth was performed on 8”/200 mm Si starting substrates.« less

General view of a Space Shuttle Main Engine (SSME) mounted ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General view of a Space Shuttle Main Engine (SSME) mounted on an SSME engine handler, taken in the SSME Processing Facility at Kennedy Space Center. The most prominent features of the engine assembly in this view are the Low-Pressure Fuel Turbopump Discharge Duct looping around the right side and underneath the assembly, the High-Pressure Fuel Turbopump located on the lower left portion of the assembly, the Engine Controller and Main Fuel Valve Hydraulic Actuator located on the upper portion of the assembly and the Low-Pressure Oxidizer Turbopump Discharge Duct at the top of the engine assembly in this view. - Space Transportation System, Space Shuttle Main Engine, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism.

PubMed

Butler, Jeffrey A; Ventura, Natascia; Johnson, Thomas E; Rea, Shane L

2010-12-01

The Caenorhabditis elegans mitochondrial (Mit) mutants have disrupted mitochondrial electron transport chain (ETC) functionality, yet, surprisingly, they are long lived. We have previously proposed that Mit mutants supplement their energy needs by exploiting alternate energy production pathways normally used by wild-type animals only when exposed to hypoxic conditions. We have also proposed that longevity in the Mit mutants arises as a property of their new metabolic state. If longevity does arise as a function of metabolic state, we would expect to find a common metabolic signature among these animals. To test these predictions, we established a novel approach monitoring the C. elegans exometabolism as a surrogate marker for internal metabolic events. Using HPLC-ultraviolet-based metabolomics and multivariate analyses, we show that long-lived clk-1(qm30) and isp-1(qm150) Mit mutants have a common metabolic profile that is distinct from that of aerobically cultured wild-type animals and, unexpectedly, wild-type animals cultured under severe oxygen deprivation. Moreover, we show that 2 short-lived mitochondrial ETC mutants, mev-1(kn1) and ucr-2.3(pk732), also share a common metabolic signature that is unique. We show that removal of soluble fumarate reductase unexpectedly increases health span in several genetically defined Mit mutants, identifying at least 1 alternate energy production pathway, malate dismutation, that is operative in these animals. Our study suggests long-lived, genetically specified Mit mutants employ a novel metabolism and that life span may well arise as a function of metabolic state.

Structural Fine-Tuning of MIT-Interacting Motif 2 (MIM2) and Allosteric Regulation of ESCRT-III by Vps4 in Yeast.

PubMed

Kojima, Rieko; Obita, Takayuki; Onoue, Kousuke; Mizuguchi, Mineyuki

2016-06-05

The endosomal sorting complex required for transport (ESCRT) facilitates roles in membrane remodeling, such as multivesicular body biogenesis, enveloped virus budding and cell division. In yeast, Vps4 plays a crucial role in intraluminal vesicle formation by disassembling ESCRT proteins. Vps4 is recruited by ESCRT-III proteins to the endosomal membrane through the interaction between the microtubule interacting and trafficking (MIT) domain of Vps4 and the C-terminal MIT-interacting motif (MIM) of ESCRT-III proteins. Here, we have determined the crystal structure of Vps4-MIT in a complex with Vps20, a member of ESCRT-III, and revealed that Vps20 adopts a unique MIM2 conformation. Based on structural comparisons with other known MIM2s, we have refined the consensus sequence of MIM2. We have shown that another ESCRT-III protein, Ist1, binds to Vps4-MIT via its C-terminal MIM1 with higher affinity than Vps2, but lacks MIM2 by surface plasmon resonance. Surprisingly, the Ist1 MIM1 competed with the MIM2 of Vfa1, a regulator of Vps4, for binding to Vps4-MIT, even though these MIMs bind in non-overlapping sites on the MIT. These findings provide insight into the allosteric recognition of MIMs of ESCRT-III by Vps4 and also the regulation of ESCRT machinery at the last step of membrane remodeling. Copyright © 2016 Elsevier Ltd. All rights reserved.

Melodic Intonation Therapy: Back to Basics for Future Research

PubMed Central

Zumbansen, Anna; Peretz, Isabelle; Hébert, Sylvie

2014-01-01

We present a critical review of the literature on melodic intonation therapy (MIT), one of the most formalized treatments used by speech-language therapist in Broca’s aphasia. We suggest basic clarifications to enhance the scientific support of this promising treatment. First, therapeutic protocols using singing as a speech facilitation technique are not necessarily MIT. The goal of MIT is to restore propositional speech. The rationale is that patients can learn a new way to speak through singing by using language-capable regions of the right cerebral hemisphere. Eventually, patients are supposed to use this way of speaking permanently but not to sing overtly. We argue that many treatment programs covered in systematic reviews on MIT’s efficacy do not match MIT’s therapeutic goal and rationale. Critically, we identified two main variations of MIT: the French thérapie mélodique et rythmée (TMR) that trains patients to use singing overtly as a facilitation technique in case of speech struggle and palliative versions of MIT that help patients with the most severe expressive deficits produce a limited set of useful, readymade phrases. Second, we distinguish between the immediate effect of singing on speech production and the long-term effect of the entire program on language recovery. Many results in the MIT literature can be explained by this temporal perspective. Finally, we propose that MIT can be viewed as a treatment of apraxia of speech more than aphasia. This issue should be explored in future experimental studies. PMID:24478754

Motor imagery training promotes motor learning in adolescents with cerebral palsy: comparison between left and right hemiparesis.

PubMed

Cabral-Sequeira, Audrey Sartori; Coelho, Daniel Boari; Teixeira, Luis Augusto

2016-06-01

This experiment was designed to evaluate the effects of pure motor imagery training (MIT) and its combination with physical practice on learning an aiming task with the more affected arm in adolescents suffering from cerebral palsy. Effect of MIT was evaluated as a function of side of hemiparesis. The experiment was accomplished by 11- to 16-year-old participants (M = 13.58 years), who suffered left (n = 16) or right (n = 15) mild hemiparesis. They were exposed to pure MIT (day 1) followed by physical practice (day 2) on an aiming task demanding movement accuracy and speed. Posttraining movement kinematics of the group receiving MIT were compared with movement kinematics of the control group after receiving recreational activities (day 1) and physical practice (day 2). Kinematic analysis showed that MIT led to decreased movement time and straighter hand displacements to the target. Performance achievements from MIT were increased with further physical practice, leading to enhanced effects on motor learning. Retention evaluation indicated that performance improvement from pure MIT and its combination with physical practice were stable over time. Performance achievements were equivalent between adolescents with either right or left hemiparesis, suggesting similar capacity between these groups to achieve performance improvement from pure imagery training and from its association with physical practice. Our results suggest that motor imagery training is a procedure potentially useful to increase motor learning achievements in individuals suffering from cerebral palsy.

One for All and All for One: Using Multiple Identification Theory Simulations to Build Cooperative Attitudes and Behaviors in a Middle Eastern Conflict Scenario

ERIC Educational Resources Information Center

Williams, Robert Howard; Williams, Alexander Jonathan

2010-01-01

The authors previously developed multiple identification theory (MIT) as a system of simulation game design intended to promote attitude change. The present study further tests MIT's effectiveness. The authors created a game (CULTURE & CREED) via MIT as a complex simulation of Middle Eastern conflict resolution, designed to change attitudes…

Latest Changes to NASA's Laser Communication Relay Demonstration Project

NASA Technical Reports Server (NTRS)

Edwards, Bernard L.; Israel, David J.; Vithlani, Seema K.

2018-01-01

Over the last couple of years, NASA has been making changes to the Laser Communications Relay Demonstration Project (LCRD), a joint project between NASA's Goddard Space Flight Center (GSFC), the Jet Propulsion Laboratory, California Institute of Technology (JPL), and the Massachusetts Institute of Technology Lincoln Laboratory (MIT/LL). The changes made makes LCRD more like a future Earth relay system that has both high speed optical and radio frequency links. This will allow LCRD to demonstrate a more detailed concept of operations for a future operational mission critical Earth relay. LCRD is expected to launch in June 2019 and is expected to be followed a couple of years later with a prototype user terminal on the International Space Station. LCRD's architecture will allow it to serve as a testbed in space and this paper will provide an update of its planned capabilities and experiments.

Modeling Weather Impact on Airport Arrival Miles-in-Trail Restrictions

NASA Technical Reports Server (NTRS)

Wang, Yao; Grabbe, Shon

2013-01-01

When the demand for either a region of airspace or an airport approaches or exceeds the available capacity, miles-in-trail (MIT) restrictions are the most frequently issued traffic management initiatives (TMIs) that are used to mitigate these imbalances. Miles-intrail operations require aircraft in a traffic stream to meet a specific inter-aircraft separation in exchange for maintaining a safe and orderly flow within the stream. This stream of aircraft can be departing an airport, over a common fix, through a sector, on a specific route or arriving at an airport. This study begins by providing a high-level overview of the distribution and causes of arrival MIT restrictions for the top ten airports in the United States. This is followed by an in-depth analysis of the frequency, duration and cause of MIT restrictions impacting the Hartsfield-Jackson Atlanta International Airport (ATL) from 2009 through 2011. Then, machine-learning methods for predicting (1) situations in which MIT restrictions for ATL arrivals are implemented under low demand scenarios, and (2) days in which a large number of MIT restrictions are required to properly manage and control ATL arrivals are presented. More specifically, these predictions were accomplished by using an ensemble of decision trees with Bootstrap aggregation (BDT) and supervised machine learning was used to train the BDT binary classification models. The models were subsequently validated using data cross validation methods. When predicting the occurrence of arrival MIT restrictions under low demand situations, the model was able to achieve over all accuracy rates ranging from 84% to 90%, with false alarm ratios ranging from 10% to 15%. In the second set of studies designed to predict days on which a high number of MIT restrictions were required, overall accuracy rates of 80% were achieved with false alarm ratios of 20%. Overall, the predictions proposed by the model give better MIT usage information than what has been currently provided under current day operations. Traffic flow managers can use these predictions to identify potential MIT restrictions to eliminate (e.g., those occurring during low arrival demand periods), and to determine the days in which a significant number of restrictions may be required

General view of a Space Shuttle Main Engine (SSME) mounted ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General view of a Space Shuttle Main Engine (SSME) mounted on an SSME engine handler, taken in the SSME Processing Facility at Kennedy Space Center. The most prominent features of the engine assembly in this view are the Low-Pressure Fuel Turbopump Discharge Duct looping diagonally across the top of the assembly and connecting to the High-Pressure Fuel Turbopump, the Low-Pressure Oxidizer Turbopump (LPOTP) located center right of the assembly and the LPOTP Discharge Duct looping around from the pump to the underside of the engine assembly in this view. - Space Transportation System, Space Shuttle Main Engine, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

NASA Propulsion Engineering Research Center, volume 2

NASA Technical Reports Server (NTRS)

1993-01-01

On 8-9 Sep. 1993, the Propulsion Engineering Research Center (PERC) at The Pennsylvania State University held its Fifth Annual Symposium. PERC was initiated in 1988 by a grant from the NASA Office of Aeronautics and Space Technology as a part of the University Space Engineering Research Center (USERC) program; the purpose of the USERC program is to replenish and enhance the capabilities of our Nation's engineering community to meet its future space technology needs. The Centers are designed to advance the state-of-the-art in key space-related engineering disciplines and to promote and support engineering education for the next generation of engineers for the national space program and related commercial space endeavors. Research on the following areas was initiated: liquid, solid, and hybrid chemical propulsion, nuclear propulsion, electrical propulsion, and advanced propulsion concepts.

Mitigation of the Impact of Sensing Noise on the Precise Formation Flying Control Problem

NASA Technical Reports Server (NTRS)

Alfriend, K. T.

2004-01-01

The specific objectives of this proposed research were: 1. Further investigation into the impact of CDGPS sensing errors for high Earth orbit missions. 2. Identify augmentation approaches of the CDGPS that will improve the relative state for low and high Earth orbit missions. 3. Integration of the navigation and control concepts into the GSFC Formation Flying Testbed. In addition this was a cooperative effort with Dr. Jonathan How at MIT. Dr. Alfriend was to spend two weeks working with Dr. How and his students. The travel for these two weeks was paid by the Texas Engineering Experiment Station (TEES) as cost sharing.

Biotechnology Process Engineering Center at MIT Home

Science.gov Websites

; < N o r m a l CJ aJ mH sH tH D A@òÿ¡ D D e f a u l t P a r a g r a p h F o n t R i@óÿ³ R T a b l e N o r m a l ö 4Ö ; l 4Ö aö ( k@ôÿÁ ( N o L i s t º@ ¦

Systems Biology-an interdisciplinary approach.

PubMed

Friboulet, Alain; Thomas, Daniel

2005-06-15

System-level approaches in biology are not new but foundations of "Systems Biology" are achieved only now at the beginning of the 21st century [Kitano, H., 2001. Foundations of Systems Biology. MIT Press, Cambridge, MA]. The renewed interest for a system-level approach is linked to the progress in collecting experimental data and to the limits of the "reductionist" approach. System-level understanding of native biological and pathological systems is needed to provide potential therapeutic targets. Examples of interdisciplinary approach in Systems Biology are described in U.S., Japan and Europe. Robustness in biology, metabolic engineering and idiotypic networks are discussed in the framework of Systems Biology.

Robot Rescue

NASA Technical Reports Server (NTRS)

Morring, Frank, Jr.

2004-01-01

Tests with robots and the high-fidelity Hubble Space Telescope mockup astronauts use to train for servicing missions have convinced NASA managers it may be possible to maintain and upgrade the orbiting observatory without sending a space shuttle to do the job. In a formal request last week, the agency gave bidders until July 16 to sub-mit proposals for a robotic mission to the space telescope before the end of 2007. At a minimum, the mission would attach a rocket motor to deorbit the telescope safely when its service life ends. In the best case, it would use state-of-the- art robotics to prolong its life on orbit and install new instruments. With the space shuttle off-limits for the job under strict post-Columbia safety policies set by Administrator Sean O'Keefe, NASA has designed a "straw- man" robotic mission that would use an Atlas V or Delta N to launch a 20,ooO-lb. "Hubble Robotic Vehicle" to service the telescope. There, a robotic arm would grapple it, much as the shuttle does.

The cost of performance - A comparison of the space transportation main engine and the Space Shuttle main engine

NASA Technical Reports Server (NTRS)

Barisa, B. B.; Flinchbaugh, G. D.; Zachary, A. T.

1989-01-01

This paper compares the cost of the Space Shuttle Main Engine (SSME) and the Space Transportation Main Engine (STME) proposed by the Advanced Launch System Program. A brief description of the SSME and STME engines is presented, followed by a comparison of these engines that illustrates the impact of focusing on acceptable performance at minimum cost (as for the STME) or on maximum performance (as for the SSME). Several examples of cost reduction methods are presented.

Future space transport

NASA Technical Reports Server (NTRS)

Grishin, S. D.; Chekalin, S. V.

1984-01-01

Prospects for the mastery of space and the basic problems which must be solved in developing systems for both manned and cargo spacecraft are examined. The achievements and flaws of rocket boosters are discussed as well as the use of reusable spacecraft. The need for orbiting satellite solar power plants and related astrionics for active control of large space structures for space stations and colonies in an age of space industrialization is demonstrated. Various forms of spacecraft propulsion are described including liquid propellant rocket engines, nuclear reactors, thermonuclear rocket engines, electrorocket engines, electromagnetic engines, magnetic gas dynamic generators, electromagnetic mass accelerators (rail guns), laser rocket engines, pulse nuclear rocket engines, ramjet thermonuclear rocket engines, and photon rockets. The possibilities of interstellar flight are assessed.

General view in the Horizontal Processing Area of the Space ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General view in the Horizontal Processing Area of the Space Shuttle Main Engine (SSME) Processing Facility at Kennedy Space Center. This view is looking at SSME number 2048 mounted on an SSME engine Handler. - Space Transportation System, Space Shuttle Main Engine, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

Interplanetary medium data book, supplement 4, 1985-1988

NASA Technical Reports Server (NTRS)

King, Joseph H.

1989-01-01

An extension is presented of the series of Interplanetary Medium Data Books and supplements which have been issued by the National Space Science Data Center since 1977. This volume contains solar wind magnetic field (IMF) and plasma data from the IMP 8 spacecraft for 1985 to 1988, and 1985 IMF data from the Czechoslovakian Soviet Prognoz 10 spacecraft. The normalization of the MIT plasma density and temperature, which has been discussed at length in previous volumes, is implemented as before, using the same normalization constants for 1985 to 1988 data as for the earlier data.

Support from the Army Research Office to be Used Towards Student Travel Fellowships for the National Radio Science Meetings in January 2010, 2011, and 2012

DTIC Science & Technology

2012-08-06

Chris Crabtree, NRL 13:20 H3-1 SIMULATIONS OF RADIATION BELT ELECTRON DYNAMICS IN HIGH-SPEED-STREAM STORMS Anthony A. Chan*1, Yen-fei Chen1, Scot ...Technology 244 Wood St., Lexington, MA 02420-9185 U.S.A. wjb@LL.MIT.EDU, 781-981-7973 David W. Miller Space Systems Laboratory, Massachusetts...R. Leslie, I. Osaretin, M. Shields Lincoln Laboratory, Massachusetts Institute of Technology 244 Wood St., Lexington, MA 02420-9185 U.S.A. wjb

The metal-insulator triple point in vanadium dioxide

NASA Astrophysics Data System (ADS)

Cobden, David

2014-03-01

The metal-insulator transition (MIT) in vanadium dioxide is a candidate for optical and electrical switching applications. However, being a first-order solid-state phase transition makes it challenging to study reproducibly in any detail. The combination of the change in unit cell shape, symmetry reduction, long range of elastic distortion, and latent heat leads to domain structure, hysteresis, and cracking of even the highest quality samples. At the MIT two stable insulating phases (M1 and M2) occur in addition to the metallic phase (R), but their phase stability diagram was poorly known. To establish it precisely we studied single-crystal nanobeams of VO2 in a purpose-built nanomechanical strain apparatus. We were able to measure the transition temperature accurately to be 65.0 +- 0.1 oC, to determine the phase boundary slopes, and to detect the intermediate metastable triclinic (T) phase where it is metastable towards M2. We were surprised to find that the transition occurs precisely at the solid-state triple point of the metallic and two insulating phases, a fact that is not explained by existing theories. See J.H. Park et al, Nature 500, 431-4 (August 2013), doi:10.1038/nature12425. Supported by US Department of Energy, Office of Basic Energy Sciences, Division of Materials Science and Engineering, award DE-SC0002197.

Validation of the Omron MIT Elite blood pressure device in a pregnant population with large arm circumference.

PubMed

James, Lauren; Nzelu, Diane; Hay, Anna; Shennan, Andrew; Kametas, Nikos A

2017-04-01

The aim of this study was to evaluate the accuracy of the Omron MIT Elite automated device in pregnant women with an arm circumference of or above 32 cm, using the British Hypertension Society validation protocol. Blood pressure was measured sequentially in 46 women of any gestation requiring the use of a large cuff (arm circumference ≥32 cm) alternating between the mercury sphygmomanometer and the Omron MIT Elite device. The Omron MIT Elite achieved an overall D/D grade with a mean of the device-observer difference being 7.17±6.67 and 9.31±6.59 for systolic and diastolic blood pressure respectively. Interobserver accuracy was 94.6% for systolic and 95% for diastolic readings within 5 mmHg. The Omron MIT Elite overestimates blood pressure and has failed the British Hypertension Society protocol requirements. Therefore, it cannot be recommended for use in pregnant women with an arm circumference of or above 32 cm.

Advancements in Transmitters and Sensors for Biological Tissue Imaging in Magnetic Induction Tomography

PubMed Central

Zakaria, Zulkarnay; Rahim, Ruzairi Abdul; Mansor, Muhammad Saiful Badri; Yaacob, Sazali; Ayub, Nor Muzakkir Nor; Muji, Siti Zarina Mohd.; Rahiman, Mohd Hafiz Fazalul; Aman, Syed Mustafa Kamal Syed

2012-01-01

Magnetic Induction Tomography (MIT), which is also known as Electromagnetic Tomography (EMT) or Mutual Inductance Tomography, is among the imaging modalities of interest to many researchers around the world. This noninvasive modality applies an electromagnetic field and is sensitive to all three passive electromagnetic properties of a material that are conductivity, permittivity and permeability. MIT is categorized under the passive imaging family with an electrodeless technique through the use of excitation coils to induce an electromagnetic field in the material, which is then measured at the receiving side by sensors. The aim of this review is to discuss the challenges of the MIT technique and summarize the recent advancements in the transmitters and sensors, with a focus on applications in biological tissue imaging. It is hoped that this review will provide some valuable information on the MIT for those who have interest in this modality. The need of this knowledge may speed up the process of adopted of MIT as a medical imaging technology. PMID:22969341

Investigation on onset voltage and conduction channel temperature in voltage-induced metal-insulator transition of vanadium dioxide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoon, Joonseok; Kim, Howon; Ju, Honglyoul, E-mail: tesl@yonsei.ac.kr

2016-03-28

The characteristics of onset voltages and conduction channel temperatures in the metal-insulator transition (MIT) of vanadium dioxide (VO{sub 2}) devices are investigated as a function of dimensions and ambient temperature. The MIT onset voltage varies from 18 V to 199 V as the device length increases from 5 to 80 μm at a fixed width of 100 μm. The estimated temperature at local conduction channel increases from 110 to 370 °C, which is higher than the MIT temperature (67 °C) of VO{sub 2}. A simple Joule-heating model is employed to explain voltage-induced MIT as well as to estimate temperatures of conduction channel appearing after MIT inmore » various-sized devices. Our findings on VO{sub 2} can be applied to micro- to nano-size tunable heating devices, e.g., microscale scanning thermal cantilevers and gas sensors.« less

Developing Technologies for Space Resource Utilization: Concept for a Planetary Engineering Research Institute

NASA Astrophysics Data System (ADS)

Blacic, J. D.; Dreesen, D.; Mockler, T.

2000-01-01

There are two principal factors that control the economics and ultimate utilization of space resources: 1) space transportation, and 2) space resource utilization technologies. Development of space transportation technology is driven by major government (military and civilian) programs and, to a lesser degree, private industry-funded research. Communication within the propulsion and spacecraft engineering community is aided by an effective independent professional organization, the American Institute of Aeronautics and Astronautics (AIAA). The many aerospace engineering programs in major university engineering schools sustain professional-level education in these fields. NASA does an excellent job of public education in space science and engineering at all levels. Planetary science, a precursor and supporting discipline for space resource utilization, has benefited from the establishment of the Lunar and Planetary Institute (LPI) which has served, since the early post-Apollo days, as a focus for both professional and educational development in the geosciences of the Moon and other planets. The closest thing the nonaerospace engineering disciplines have had to this kind of professional nexus is the sponsorship by the American Society of Civil Engineers of a series of space engineering conferences that have had a predominantly space resource orientation. However, many of us with long-standing interests in space resource development have felt that an LPI-like, independent institute was needed to focus and facilitate both research and education on the specific engineering disciplines needed to develop space resource utilization technologies on an on-going basis.

Thousands gather to watch a Space Shuttle Main Engine Test

NASA Image and Video Library

2001-04-21

Approximately 13,000 people fill the grounds at NASA's John C. Stennis Space Center for the first-ever evening public engine test of a Space Shuttle Main Engine. The test marked Stennis Space Center's 20th anniversary celebration of the first Space Shuttle mission.

Orbit Transfer Rocket Engine Technology Program: Advanced engine study, task D.1/D.3

NASA Technical Reports Server (NTRS)

Martinez, A.; Erickson, C.; Hines, B.

1986-01-01

Concepts for space maintainability of OTV engines were examined. An engine design was developed which was driven by space maintenance requirements and by a failure mode and effects (FME) analysis. Modularity within the engine was shown to offer cost benefits and improved space maintenance capabilities. Space operable disconnects were conceptualized for both engine change-out and for module replacement. Through FME mitigation the modules were conceptualized to contain the least reliable and most often replaced engine components. A preliminary space maintenance plan was developed around a controls and condition monitoring system using advanced sensors, controls, and condition monitoring concepts. A complete engine layout was prepared satisfying current vehicle requirements and utilizing projected component advanced technologies. A technology plan for developing the required technology was assembled.

Minimally invasive thyroidectomy (MIT): indications and results.

PubMed

Docimo, Giovanni; Salvatore Tolone, Salvatore; Gili, Simona; d'Alessandro, A; Casalino, G; Brusciano, L; Ruggiero, Roberto; Docimo, Ludovico

2013-01-01

To establish if the indication for different approaches for thyroidectomy and the incision length provided by means of pre-operative assessment of gland volume and size of nodules resulted in safe and effective outcomes and in any notable aesthetic or quality-of-life impact on patients. Ninehundred eightytwo consecutive patients, undergoing total thyroidectomy, were enrolled. The thyroid volume and maximal nodule diameter were measured by means of ultrasounds. Based on ultrasounds findings, patients were divided into three groups: minimally invasive video assisted thyroidectomy (MIVAT), minimally invasive thyroidectomy (MIT) and conventional thyroidectomy (CT) groups. The data concerning the following parameters were collected: operative time, postoperative complications, postoperative pain and cosmetic results. The MIVAT group included 179 patients, MIT group included 592 patients and CT group included 211 patients. Incidence of complications did not differ significantly in each group. In MIVAT and MIT group, the perception of postoperative pain was less intense than CT group. The patients in the MIVAT (7±1.5) and MIT (8±2) groups were more satisfied with the cosmetic results than those in CT group (5±1.3) (p= <0.05). The MIT is a technique totally reproducible, and easily convertible to perform surgical procedures in respect of the patient, without additional complications, increased costs, and with better aesthetic results.

Collaborative gaming and competition for CS-STEM education using SPHERES Zero Robotics

NASA Astrophysics Data System (ADS)

Nag, Sreeja; Katz, Jacob G.; Saenz-Otero, Alvar

2013-02-01

There is widespread investment of resources in the fields of Computer Science, Science, Technology, Engineering, Mathematics (CS-STEM) education to improve STEM interests and skills. This paper addresses the goal of revolutionizing student education using collaborative gaming and competition, both in virtual simulation environments and on real hardware in space. The concept is demonstrated using the SPHERES Zero Robotics (ZR) Program which is a robotics programming competition. The robots are miniature satellites called SPHERES—an experimental test bed developed by the MIT SSL on the International Space Station (ISS) to test navigation, formation flight and control algorithms in microgravity. The participants compete to win a technically challenging game by programming their strategies into the SPHERES satellites, completely from a web browser. The programs are demonstrated in simulation, on ground hardware and then in a final competition when an astronaut runs the student software aboard the ISS. ZR had a pilot event in 2009 with 10 High School (HS) students, a nationwide pilot tournament in 2010 with over 200 HS students from 19 US states, a summer tournament in 2010 with ˜150 middle school students and an open-registration tournament in 2011 with over 1000 HS students from USA and Europe. The influence of collaboration was investigated by (1) building new web infrastructure and an Integrated Development Environment where intensive inter-participant collaboration is possible, (2) designing and programming a game to solve a relevant formation flight problem, collaborative in nature—and (3) structuring a tournament such that inter-team collaboration is mandated. This paper introduces the ZR web tools, assesses the educational value delivered by the program using space and games and evaluates the utility of collaborative gaming within this framework. There were three types of collaborations as variables—within matches (to achieve game objectives), inter-team alliances and unstructured communication on online forums. Simulation competition scores, website usage statistics and post-competition surveys are used to evaluate educational impact and the effect of collaboration.

Closeup view of the top of Space Shuttle Main Engine ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Close-up view of the top of Space Shuttle Main Engine (SSME) 2057 mounted in a SSME Engine Handler in the Vertical Processing area of the SSME Processing Facility at Kennedy Space Center. The most prominent components in this view is the large Low-Pressure Oxidizer Turbopump (LPOTP) Discharge Duct wrapping itself around the right side of the engine assembly. The smaller tube to the left of LPOTP Discharge Duct is the High-Pressure Oxidizer Duct used to supply the turbine of the LPOTP. The other major feature in this view is the Low-Pressure Fuel Turbopump at the top of the engine assembly. - Space Transportation System, Space Shuttle Main Engine, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

Kompressionstherapie bei Patienten mit Ulcus cruris venosum.

PubMed

Dissemond, Joachim; Assenheimer, Bernd; Bültemann, Anke; Gerber, Veronika; Gretener, Silvia; Kohler-von Siebenthal, Elisabeth; Koller, Sonja; Kröger, Knut; Kurz, Peter; Läuchli, Severin; Münter, Christian; Panfil, Eva-Maria; Probst, Sebastian; Protz, Kerstin; Riepe, Gunnar; Strohal, Robert; Traber, Jürg; Partsch, Hugo

2016-11-01

Wund-D.A.CH. ist der Dachverband deutschsprachiger Fachgesellschaften, die sich mit den Thematiken der Wundbehandlung beschäftigen. Experten verschiedener Fachgesellschaften aus Deutschland, Österreich und der Schweiz haben nun einen aktuellen Konsens der Kompressionstherapie für Patienten mit Ulcus cruris venosum erstellt. In Europa ist das Ulcus cruris venosum eine der häufigsten Ursachen für chronische Wunden. Neben der konservativen und interventionellen Wund- und Venentherapie, ist die Kompressionstherapie die Basis der Behandlungsstrategien. Die Kompressionstherapie kann heute mit sehr unterschiedlichen Materialien und Systemen durchgeführt werden. Während in der Entstauungsphase insbesondere Verbände mit Kurzzugbinden oder Mehrkomponentensysteme zur Anwendung kommen, sind es anschließend überwiegend Ulkus-Strumpfsysteme. Eine weitere, bislang wenig verbreitete Alternative sind adaptive Kompressionsbandagen. Insbesondere für die Rezidivprophylaxe werden medizinische Kompressionsstrümpfe empfohlen. Durch die Vielzahl der heute zur Verfügung stehenden Behandlungsoptionen, kann für nahezu alle Patienten ein Konzept entwickelt werden, dass sich an den individuellen Bedürfnissen und Fähigkeiten orientiert und daher auch akzeptiert und durchgeführt wird. Die Kompressionstherapie ist für die Behandlung von Patienten mit Ulcus cruris venosum essentiell. In den letzten Jahren sind viele verschiedene Therapieoptionen verfügbar, die in den deutschsprachigen Ländern unterschiedlich angewendet oder durchgeführt werden. Daher soll dieser Expertenkonsens dazu beitragen, konkrete Empfehlungen für die praktische Durchführung der Kompressionstherapie von Patienten mit Ulcus cruris venosum darzustellen. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs).

PubMed

Han, Han; Monroe, Nicole; Votteler, Jörg; Shakya, Binita; Sundquist, Wesley I; Hill, Christopher P

2015-05-22

The endosomal sorting complexes required for transport (ESCRT) pathway drives reverse topology membrane fission events within multiple cellular pathways, including cytokinesis, multivesicular body biogenesis, repair of the plasma membrane, nuclear membrane vesicle formation, and HIV budding. The AAA ATPase Vps4 is recruited to membrane necks shortly before fission, where it catalyzes disassembly of the ESCRT-III lattice. The N-terminal Vps4 microtubule-interacting and trafficking (MIT) domains initially bind the C-terminal MIT-interacting motifs (MIMs) of ESCRT-III subunits, but it is unclear how the enzyme then remodels these substrates in response to ATP hydrolysis. Here, we report quantitative binding studies that demonstrate that residues from helix 5 of the Vps2p subunit of ESCRT-III bind to the central pore of an asymmetric Vps4p hexamer in a manner that is dependent upon the presence of flexible nucleotide analogs that can mimic multiple states in the ATP hydrolysis cycle. We also find that substrate engagement is autoinhibited by the Vps4p MIT domain and that this inhibition is relieved by binding of either Type 1 or Type 2 MIM elements, which bind the Vps4p MIT domain through different interfaces. These observations support the model that Vps4 substrates are initially recruited by an MIM-MIT interaction that activates the Vps4 central pore to engage substrates and generate force, thereby triggering ESCRT-III disassembly. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Monitoring of allograft vasculopathy by intravascular ultrasound one month and one year after heart transplantation: A single center study.

PubMed

Bedanova, Helena; Orban, Marek; Tretina, Martin; Fila, Petr; Horvath, Vladimir; Krejci, Jan; Nemec, Petr

2016-03-01

The aim of this trial was to use intravascular ultrasound (IVUS) to determine whether cardiac allograft vasculopathy (CAV) starts progressing during the first year after heart transplantation (HTx). We retrospectively analyzed 51 patients (11 women) who received heart transplants in our center between January 2010 and September 2013 and underwent coronary angiography as well as IVUS examination one month and one year after HTx. Patients with proven calcification and fibrotic plates in the IVUS examination one month after HTx constituted a group with defined donor-transmitted atherosclerosis (DTA). In patients without DTA, measurements of maximal intimal thickening (MIT) were made in two predetermined locations. Eight of the 51 patients had DTA, while 43 did not. These were divided based on maximal intimal thickness (MIT) into a group with MIT < 0.5 mm (27) and MIT ≥ 0.5 mm (16). No patient with MIT < 0.5 mm developed allograft vasculopathy within one year after HTx. CAV developed in three patients (P = 0.045) out of the 16 patients with MIT ≥ 0.5. In patients with DTA, a statistically significant deterioration in percent area stenosis (PAS) occurred in both artery sections (P = 0.01). Our trial showed that CAV progresses during the first year after HTx significantly more frequently in patients with DTA and MIT ≥ 0.5 mm. It is essential in these patients to implement an IVUS control examination one year after transplantation. The results can lead to a change in treatment strategy to prevent further progress of the disease.

Private-sector Support of Research at the Massachusetts Institute of Technology

NASA Astrophysics Data System (ADS)

Zuber, M. T.; Christy, M. D.

2016-12-01

In fiscal year 2016, 66% of MIT's external research support came from federal sources. This percentage is the lowest since federal funding of university research initiated circa World War II. The percentage has dropped precipitously since the financial crisis of 2008 and the advent of sequestration, and the most optimistic scenario in the near future is flat to mildly increasing federal investments in research. Of the one-third of MIT's research supported by non-federal sources, 18% comes from industry, and the remainder comes from foundations, non-profits, and state and foreign governments. The overwhelming majority of non-federal support is for applied rather than basic research. Non-federal support of research in the geosciences comes from all these sources. In accepting research support from industry MIT must balance the desires of faculty and research staff to work in collaboration with companies of their choosing, with the essential need to set conditions that ensure independent scholarship. Participation in research projects is at the discretion of the Principal Investigator, and must be fully consistent with MIT's non-discrimination and open access policies. In all research agreements, MIT requires that faculty, students and research staff are able to freely present and publish results. While MIT's research partners help to identify research areas of mutual interest and may consult on research as it moves forward, MIT faculty members, researchers, post-doctoral scholars and students retain control over the design and management of their research projects at all times. The Institute also requires the identification and management of any conflicts of interest.

Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs)*

PubMed Central

Han, Han; Monroe, Nicole; Votteler, Jörg; Shakya, Binita; Sundquist, Wesley I.; Hill, Christopher P.

2015-01-01

The endosomal sorting complexes required for transport (ESCRT) pathway drives reverse topology membrane fission events within multiple cellular pathways, including cytokinesis, multivesicular body biogenesis, repair of the plasma membrane, nuclear membrane vesicle formation, and HIV budding. The AAA ATPase Vps4 is recruited to membrane necks shortly before fission, where it catalyzes disassembly of the ESCRT-III lattice. The N-terminal Vps4 microtubule-interacting and trafficking (MIT) domains initially bind the C-terminal MIT-interacting motifs (MIMs) of ESCRT-III subunits, but it is unclear how the enzyme then remodels these substrates in response to ATP hydrolysis. Here, we report quantitative binding studies that demonstrate that residues from helix 5 of the Vps2p subunit of ESCRT-III bind to the central pore of an asymmetric Vps4p hexamer in a manner that is dependent upon the presence of flexible nucleotide analogs that can mimic multiple states in the ATP hydrolysis cycle. We also find that substrate engagement is autoinhibited by the Vps4p MIT domain and that this inhibition is relieved by binding of either Type 1 or Type 2 MIM elements, which bind the Vps4p MIT domain through different interfaces. These observations support the model that Vps4 substrates are initially recruited by an MIM-MIT interaction that activates the Vps4 central pore to engage substrates and generate force, thereby triggering ESCRT-III disassembly. PMID:25833946

Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.

PubMed

Osako, Yohei; Maemoto, Yuki; Tanaka, Ryohei; Suzuki, Hironori; Shibata, Hideki; Maki, Masatoshi

2010-11-01

Calpain 7, a mammalian ortholog of yeast Cpl1/Rim13 and fungal PalB, is an atypical calpain that lacks a penta-EF-hand domain. Previously, we reported that a region containing a tandem repeat of microtubule-interacting and transport (MIT) domains in calpain 7 interacts with a subset of endosomal sorting complex required for transport (ESCRT)-III-related proteins, suggesting involvement of calpain 7 in the ESCRT system. Although yeast and fungal calpains are thought to be involved in alkaline adaptation via limited proteolysis of specific transcription factors, proteolytic activity of calpain 7 has not been demonstrated yet. In this study, we investigated the interaction between calpain 7 and a newly reported ESCRT-III family member, increased sodium tolerance-1 (IST1), which possesses two different types of MIT-interacting motifs (MIM1 and MIM2). We found that glutathione-S-transferase (GST)-fused tandem MIT domains of calpain 7 (calpain 7MIT) pulled down FLAG-tagged IST1 expressed in HEK293T cells. Coimmunoprecipitation assays with various deletion or point mutants of epitope-tagged calpain 7 and IST1 revealed that both repetitive MIT domains and MIMs are required for efficient interaction. Direct MIT-MIM binding was confirmed by a pulldown experiment with GST-fused IST1 MIM and purified recombinant calpain 7MIT. Furthermore, we found that the GST-MIM protein enhances the autolysis of purified Strep-tagged monomeric green fluorescent protein (mGFP)-fused calpain 7 (mGFP-calpain 7-Strep). The autolysis was almost completely abolished by 10 mmN-ethylmaleimide but only partially inhibited by 1 mm leupeptin or E-64. The putative catalytic Cys290-substituted mutant (mGFP-calpain 7(C290S)-Strep) showed no autolytic activity. These results demonstrate for the first time that human calpain 7 is proteolytically active, and imply that calpain 7 is activated in the ESCRT system. © 2010 The Authors Journal compilation © 2010 FEBS.

Intraläsionale Therapie niedrig maligner primär kutaner B-Zell-Lymphome mit Anti-CD20-Antikörper: Nebenwirkungen korrelieren mit gutem klinischen Ansprechen.

PubMed

Eberle, Franziska C; Holstein, Julia; Scheu, Alexander; Fend, Falko; Yazdi, Amir S

2017-03-01

Die intraläsionale Gabe von Anti-CD20-Antikörpern (Rituximab) wurde als effektive Therapieoption für Patienten mit niedrig malignen primär kutanen B-Zell-Lymphomen beschrieben. Bis heute wurden allerdings keine Parameter identifiziert, welche reproduzierbar ein gutes klinisches Ansprechen dieser Therapie vorhersagen. Ziel dieser Studie ist, sowohl das klinische Ansprechen und die unerwünschten Nebenwirkungen als auch die Patientenwahrnehmung hinsichtlich intraläsionaler Injektionen von anti-CD20-Antikörpern zur Behandlung indolenter primär kutaner B-Zell-Lymphome im Vergleich mit anderen Therapien zu evaluieren. Elf Patienten mit einem primär kutanen B-Zell-Lymphom, namentlich primär kutanes Keimzentrumslymphom (n = 9) und primär kutanes Marginalzonenlymphom (n = 2), welche mittels intraläsionalem Anti-CD20-Antikörper behandelt wurden, wurden retrospektiv evaluiert hinsichtlich der Ansprechrate und unerwünschter Nebenwirkungen sowie in Bezug auf deren Selbsteinschätzung dieser und anderer Therapien des primär kutanen B-Zell-Lymphoms. Patienten, deren primär kutanes B-Zell-Lymphom mittels intraläsionaler Gabe von Anti-CD20-Antikörper behandelt wurde, zeigten ein komplettes oder partielles Ansprechen in 45 % beziehungsweise 27 % aller Patienten. Speziell Patienten mit grippeähnlichen Symptomen nach erfolgter Injektion zeigten ein gutes Ansprechen. Die Mehrheit der Patienten empfand die Therapie mit Rituximab als die beste Therapie im Vergleich zu anderen Therapien wie beispielsweise chirurgische Exzision oder Radiotherapie. Intraläsionales Rituximab ist eine effektive Therapie mit hoher Patientenzufriedenheit. Starke therapiebedingte Nebenwirkungen wie Fieber, Schüttelfrost und Kopfschmerzen nach Gabe von Rituximab könnten als Indikator für gute Wirksamkeit dienen. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

MitProNet: A Knowledgebase and Analysis Platform of Proteome, Interactome and Diseases for Mammalian Mitochondria

PubMed Central

Mao, Song; Chai, Xiaoqiang; Hu, Yuling; Hou, Xugang; Tang, Yiheng; Bi, Cheng; Li, Xiao

2014-01-01

Mitochondrion plays a central role in diverse biological processes in most eukaryotes, and its dysfunctions are critically involved in a large number of diseases and the aging process. A systematic identification of mitochondrial proteomes and characterization of functional linkages among mitochondrial proteins are fundamental in understanding the mechanisms underlying biological functions and human diseases associated with mitochondria. Here we present a database MitProNet which provides a comprehensive knowledgebase for mitochondrial proteome, interactome and human diseases. First an inventory of mammalian mitochondrial proteins was compiled by widely collecting proteomic datasets, and the proteins were classified by machine learning to achieve a high-confidence list of mitochondrial proteins. The current version of MitProNet covers 1124 high-confidence proteins, and the remainders were further classified as middle- or low-confidence. An organelle-specific network of functional linkages among mitochondrial proteins was then generated by integrating genomic features encoded by a wide range of datasets including genomic context, gene expression profiles, protein-protein interactions, functional similarity and metabolic pathways. The functional-linkage network should be a valuable resource for the study of biological functions of mitochondrial proteins and human mitochondrial diseases. Furthermore, we utilized the network to predict candidate genes for mitochondrial diseases using prioritization algorithms. All proteins, functional linkages and disease candidate genes in MitProNet were annotated according to the information collected from their original sources including GO, GEO, OMIM, KEGG, MIPS, HPRD and so on. MitProNet features a user-friendly graphic visualization interface to present functional analysis of linkage networks. As an up-to-date database and analysis platform, MitProNet should be particularly helpful in comprehensive studies of complicated biological mechanisms underlying mitochondrial functions and human mitochondrial diseases. MitProNet is freely accessible at http://bio.scu.edu.cn:8085/MitProNet. PMID:25347823

RS-25 engine

NASA Image and Video Library

2012-04-10

The last of 15 RS-25 rocket engines arrived at Stennis Space Center from Kennedy Space Center in Flordia , on April 10, 2012. The engines will be stored at Stennis until testing begins for the engines to be used on NASA's new Space Launch System.

General view in the Horizontal Processing Area of the Space ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General view in the Horizontal Processing Area of the Space Shuttle Main Engine (SSME) Processing Facility at Kennedy Space Center. This view is looking at SSME 2052 and 2051 mounted on their SSME Engine Handlers. - Space Transportation System, Space Shuttle Main Engine, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

Anisotropic magnetic properties of the KMo4O6

NASA Astrophysics Data System (ADS)

Andrade, M.; Maffei, M. L.; Dos Santos, C. A. M.; Ferreira, B.; Sartori, A. F.

2012-02-01

Electrical resistivity measurements in the tetragonal KMo4O6 single crystals show a metal-insulator transition (MIT) near 100K. Magnetization measurements as a function of temperature show no evidence of magnetic ordering at this MIT [1]. Single crystals of KMo4O6 were obtained by electrolysis of a melt with a molar ratio of K2MoO4:MoO3 = 6:1. The process were carried out at 930 C with a current of 20-25mA for 52h in argon atmosphere. After that, electrodes were removed from the melt alloying the crystals to cool down to room temperature rapidly. Scanning Electron Microscopy (SEM) showed that the black single crystals were grown on the platinum cathode. Typical dimensions of the single crystals are 1x0.2x0.2mm^3. X-ray diffractometry confirmed that the single crystals have KMo4O6 tetragonal crystalline structure with space group P4. Magnetization measurements were performed parallel and perpendicular to the c-axis from 2 to 300K. The results show anisotropic behavior between both directions. Furthermore, the temperature independence of the magnetization at high temperature and the upturn at low temperature are observed in agreement with previous results [1]. MxH curves measured at several temperatures show nonlinear behavior and a small magnetic ordering. The magnetic ordering seems to be related to the MIT near 100K. This material is based upon support by FAPESP (2009/14524-6 and 2009/54001-6) and CNPq/NSF (490182/2009-7). M. Andrade is CAPES fellow and C.A.M. dos Santos is CNPq fellow. [4pt] [1] K. V. Ramanujachary et al., J. Sol. State Chem.102 (1993) 69.

Reaction Control Engine for Space Launch Initiative

NASA Technical Reports Server (NTRS)

2002-01-01

Engineers at the Marshall Space Flight Center (MSFC) have begun a series of engine tests on a new breed of space propulsion: a Reaction Control Engine developed for the Space Launch Initiative (SLI). The engine, developed by TRW Space and Electronics of Redondo Beach, California, is an auxiliary propulsion engine designed to maneuver vehicles in orbit. It is used for docking, reentry, attitude control, and fine-pointing while the vehicle is in orbit. The engine uses nontoxic chemicals as propellants, a feature that creates a safer environment for ground operators, lowers cost, and increases efficiency with less maintenance and quicker turnaround time between missions. Testing includes 30 hot-firings. This photograph shows the first engine test performed at MSFC that includes SLI technology. Another unique feature of the Reaction Control Engine is that it operates at dual thrust modes, combining two engine functions into one engine. The engine operates at both 25 and 1,000 pounds of force, reducing overall propulsion weight and allowing vehicles to easily maneuver in space. The low-level thrust of 25 pounds of force allows the vehicle to fine-point maneuver and dock while the high-level thrust of 1,000 pounds of force is used for reentry, orbit transfer, and coarse positioning. SLI is a NASA-wide research and development program, managed by the MSFC, designed to improve safety, reliability, and cost effectiveness of space travel for second generation reusable launch vehicles.

NASA Marches on with Test of RS-25 Engine for New Space Launch System

NASA Image and Video Library

2016-07-29

NASA engineers conducted a successful developmental test of RS-25 rocket engine No. 0528 July 29, 2016, to collect critical performance data for the most powerful rocket in the world – the Space Launch System (SLS). The engine roared to life for a full 650-second test on the A-1 Test Stand at NASA’s Stennis Space Center, near Bay St. Louis, Mississippi, marking another step forward in development of the SLS, which will launch humans deeper into space than ever before, including on the journey to Mars. Four RS-25 engines, joined with a pair of solid rocket boosters, will power the SLS core stage at launch. The RS-25 engines used on the first four SLS flights are former space shuttle main engines, modified to operate at a higher performance level and with a new engine controller, which allows communication between the vehicle and engine.

Analytische Geometrie

NASA Astrophysics Data System (ADS)

Kemnitz, Arnfried

Der Grundgedanke der Analytischen Geometrie besteht darin, dass geometrische Untersuchungen mit rechnerischen Mitteln geführt werden. Geometrische Objekte werden dabei durch Gleichungen beschrieben und mit algebraischen Methoden untersucht.

Closeup view of a Space Shuttle Main Engine (SSME) installed ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Close-up view of a Space Shuttle Main Engine (SSME) installed in position number one on the Orbiter Discovery. A ground-support mobile platform is in place below the engine to assist in technicians with the installation of the engine. This Photograph was taken in the Orbiter Processing Facility at the Kennedy Space Center. - Space Transportation System, Orbiter Discovery (OV-103), Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

Improving the Effectiveness of Speaker Verification Domain Adaptation With Inadequate In-Domain Data

DTIC Science & Technology

2017-08-20

Improving the Effectiveness of Speaker Verification Domain Adaptation With Inadequate In-Domain Data Bengt J. Borgström1, Elliot Singer1, Douglas...ll.mit.edu.edu, dar@ll.mit.edu, es@ll.mit.edu, omid.sadjadi@nist.gov Abstract This paper addresses speaker verification domain adaptation with...contain speakers with low channel diversity. Existing domain adaptation methods are reviewed, and their shortcomings are discussed. We derive an

Mitochondrial-type hsp70 genes of the amitochondriate protists, Giardia intestinalis, Entamoeba histolytica and two microsporidians☆

PubMed Central

Arisue, Nobuko; Sánchez, Lidya B.; Weiss, Louis M.; Müller, Miklós; Hashimoto, Tetsuo

2011-01-01

Genes encoding putative mitochondrial-type heat shock protein 70 (mit-hsp70) were isolated and sequenced from amitochondriate protists, Giardia intestinalis, Entamoeba histolytica, and two microsporidians, Encephalitozoon hellem and Glugea plecoglossi. The deduced mit-hsp70 sequences were analyzed by sequence alignments and phylogenetic reconstructions. The mit-hsp70 sequence of these four amitochondriate protists were divergent from other mit-hsp70 sequences of mitochondriate eukaryotes. However, all of these sequences were clearly located within a eukaryotic mitochondrial clade in the tree including various type hsp70 sequences, supporting the emerging notion that none of these amitochondriate lineages are primitively amitochodrial, but lost their mitochondria secondarily in their evolutionary past. PMID:11880223

Development and evaluation of form three mathematics i-Think module (Mi-T3) on algebraic formulae topic

NASA Astrophysics Data System (ADS)

Sam, Sazilah; Abdullah, Mohd Faizal Nizam Lee

2017-05-01

This article introduces the Form Three Mathematics i-Think Module (Mi-T3). The main objective of this Mi-T3 is to assist form three students develop their higher order thinking skills (HOTS). The Sidek Module Development Model (SMDM) and eight innovative thinking maps (i-Think) were applied as a guideline in developing Mi-T3. A validation stage was carried out by eight experts, and content validation achievement more than 90% obtained. A group of form three students and teachers was piloted to check the module's reliability through one to one and small group evaluation and Cronbach Alpha more than 0.90 was obtained. Implications of the study are discussed in this article.

Earth Institute at Columbia University ADVANCE Program: Addressing Needs for Women in Earth and Environmental Sciences

NASA Astrophysics Data System (ADS)

Bell, R. E.; Cane, M.; Mutter, J.; Miller, R.; Pfirman, S.; Laird, J.

2004-12-01

The Earth Institute has received a major NSF ADVANCE grant targeted at increasing the participation and advancement of women scientists and engineers in the Academy through institutional transformation. The Earth Institute at Columbia University includes 9 research institutes including Lamont-Doherty Earth Observatory, Center for Environmental Research and Conservation (CERC), Center for International Earth Science Information Network (CIESIN), International Research Institute (IRI) for Climate Prediction, Earth Engineering Center, NASA-Goddard Institute for Space Studies, Center for Risks and Hazards, Center for Globalization and Sustainable Development, and Center for Global Health and Economic Development and six academic departments including Ecology, Evolution and Environmental Biology (E3B, School of Arts and Sciences), Earth and Environmental Engineering (DEEE, School of Engineering and Applied Sciences), Department of Environmental Health (School of Public Health), Department of Earth and Environmental Sciences (DEES, School of Arts and Sciences), Department of International and Public Affairs (School of International and Policy Affairs), and Barnard College Department of Environmental Science. The Earth Institute at Columbia University's ADVANCE program is based both on a study of the status of women at Columbia and research on the progression of women in science elsewhere. The five major targets of the Columbia ADVANCE program are to (1) change the demographics of the faculty through intelligent hiring practices, (2) provide support to women scientists through difficult life transitions including elder care and adoption or birth of a child, (3) enhance mentoring and networking opportunities, (4) implement transparent promotion procedures and policies, and (5) conduct an institutional self study. The Earth Institute ADVANCE program is unique in that it addresses issues that tend to manifest themselves in the earth and environmental fields, such as extended field programs, which lay the foundation for leadership positions, but which may be difficult for young faculty. The strategy is to use the Earth Institute as a test bed for institutional change, and then expand the successful programs to other Columbia Science and Engineering Departments, as appropriate. Columbia's administration is committed to changing policies and supporting successful programs beyond the completion of the NSF grant. Earth Institute ADVANCE programs include (a) a self study including a climate survey modeled after the 1999 MIT study, (b) a senior faculty working group that will facilitate recruitment and retention by providing support for searches, faculty development, and retention, (c) internal funding competitions designed to recruit and retain women scientists and engineers, and (d) focused workshops and conferences. The ADVANCE program will establish offices both on the Morningside campus in Manhattan and Lamont campus in Palisades, NY.

Nuclear Security Education Program at the Pennsylvania State University

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uenlue, Kenan; The Pennsylvania State University, Department of Mechanical and Nuclear Engineering, University Park, PA 16802-2304; Jovanovic, Igor

The availability of trained and qualified nuclear and radiation security experts worldwide has decreased as those with hands-on experience have retired while the demand for these experts and skills have increased. The U.S. Department of Energy's National Nuclear Security Administration's (NNSA) Global Threat Reduction Initiative (GTRI) has responded to the continued loss of technical and policy expertise amongst personnel and students in the security field by initiating the establishment of a Nuclear Security Education Initiative, in partnership with Pennsylvania State University (PSU), Texas A and M (TAMU), and Massachusetts Institute of Technology (MIT). This collaborative, multi-year initiative forms the basismore » of specific education programs designed to educate the next generation of personnel who plan on careers in the nonproliferation and security fields with both domestic and international focus. The three universities worked collaboratively to develop five core courses consistent with the GTRI mission, policies, and practices. These courses are the following: Global Nuclear Security Policies, Detectors and Source Technologies, Applications of Detectors/Sensors/Sources for Radiation Detection and Measurements Nuclear Security Laboratory, Threat Analysis and Assessment, and Design and Analysis of Security Systems for Nuclear and Radiological Facilities. The Pennsylvania State University (PSU) Nuclear Engineering Program is a leader in undergraduate and graduate-level nuclear engineering education in the USA. The PSU offers undergraduate and graduate programs in nuclear engineering. The PSU undergraduate program in nuclear engineering is the largest nuclear engineering programs in the USA. The PSU Radiation Science and Engineering Center (RSEC) facilities are being used for most of the nuclear security education program activities. Laboratory space and equipment was made available for this purpose. The RSEC facilities include the Penn State Breazeale Reactor (PSBR), gamma irradiation facilities (in-pool irradiator, dry irradiator, and hot cells), neutron beam laboratory, radiochemistry laboratories, and various radiation detection and measurement laboratories. A new nuclear security education laboratory was created with DOE NNSA- GTRI funds at RSEC. The nuclear security graduate level curriculum enables the PSU to educate and train future nuclear security experts, both within the United States as well as worldwide. The nuclear security education program at Penn State will grant a Master's degree in nuclear security starting fall 2015. The PSU developed two courses: Nuclear Security- Detector And Source Technologies and Nuclear Security- Applications of Detectors/Sensors/Sources for Radiation Detection and Measurements (Laboratory). Course descriptions and course topics of these courses are described briefly: - Nuclear Security - Detector and Source Technologies; - Nuclear Security - Applications of Detectors/Sensors/Sources for Radiation Detection and Measurements Laboratory.« less

Space Transportation Main Engine

NASA Technical Reports Server (NTRS)

Monk, Jan C.

1992-01-01

The topics are presented in viewgraph form and include the following: Space Transportation Main Engine (STME) definition, design philosophy, robust design, maximum design condition, casting vs. machined and welded forgings, operability considerations, high reliability design philosophy, engine reliability enhancement, low cost design philosophy, engine systems requirements, STME schematic, fuel turbopump, liquid oxygen turbopump, main injector, and gas generator. The major engine components of the STME and the Space Shuttle Main Engine are compared.

A comparison of screw insertion torque and pullout strength.

PubMed

Ricci, William M; Tornetta, Paul; Petteys, Timothy; Gerlach, Darin; Cartner, Jacob; Walker, Zakiyyah; Russell, Thomas A

2010-06-01

Pullout strength of screws is a parameter used to evaluate plate screw fixation strength. However, screw fixation strength may be more closely related to its ability to generate sufficient insertion because stable nonlocked plate-screw fracture fixation requires sufficient compression between plate and bone such that no motion occurs between the plate and bone under physiological loads. Compression is generated by tightening of screws. In osteoporotic cancellous bone, sufficient screw insertion torque may not be generated before screw stripping. The effect of screw thread pitch on generation of maximum insertion torque (MIT) and pullout strength (POS) was investigated in an osteoporotic cancellous bone model and the relationship between MIT and POS was analyzed. Stainless steel screws with constant major (5.0 mm) and minor (2.7 mm) diameters but with varying thread pitches (1, 1.2, 1.5, 1.6, and 1.75 mm) were tested for MIT and POS in a validated osteoporotic surrogate for cancellous bone (density of 160 kg/m(3) [10 lbs/ft(3)]). MIT was measured with a torque-measuring hex driver for screws inserted through a one-third tubular plate. POS was measured after insertion of screws to a depth of 20 mm based on the Standard Specification and Test Methods for Metallic Medical Bone Screws (ASTM F 543-07). Five screws were tested for each failure mode and screw design. The relationship between MIT and compressive force between the plate and bone surrogate was evaluated using pressure-sensitive film. There was a significant difference in mean MIT based on screw pitch (P < 0.0001), whereas POS did not show statistically significant differences among the different screw pitches (P = 0.052). Small screw pitches (1.0 mm and 1.2 mm) had lower MIT and were distinguished from large pitches (1.5 mm, 1.6 mm, and the 1.75 mm) with higher MIT. For POS, only the 1-mm and 1.6-mm pitch screws were found to be different from each other. Linear regression analysis of MIT revealed a moderate correlation to the screw pitch (R(2) = 0.67, P < 0.0001), whereas the analysis of POS suggested no correlation to the screw pitch (R(2) = 0.28, P = 0.006). Pearson correlation analysis indicated no correlation between MIT and POS (P = 0.069, r = -0.37). A linear relationship of increased compression between the plate and bone surrogate was found for increasing screw torque (R(2) = 0.97). These results indicate that the ability of different screw designs to generate high screw insertion torque in a model of osteoporotic cancellous bone is unrelated to their pullout strength. Therefore, extrapolation of results for POS to identify optimal screw design for osteoporotic bone may not be valid. Screw designs that optimize MIT should be sought for fixation in osteoporotic bone.

Preparing for Flight Engine Test

NASA Image and Video Library

2015-11-04

The first RS-25 flight engine, engine No. 2059, is lifted onto the A-1 Test Stand at Stennis Space Center on Nov. 4, 2015. The engine was tested in early 2016 to certify it for use on NASA’s new Space Launch System (SLS). The SLS core stage will be powered by four RS-25 engines, all tested at Stennis Space Center. NASA is developing the SLS to carry humans deeper into space than ever before, including on a journey to Mars.

Space Station Engineering and Technology Development: Proceedings of the Panel on In-Space Engineering Research and Technology Development

NASA Technical Reports Server (NTRS)

1985-01-01

In 1984 the ad hoc committee on Space Station Engineering and Technology Development of the Aeronautics and Space Engineering Board (ASEB) conducted a review of the National Aeronautics and Space Administration's (NASA's) space station program planning. The review addressed the initial operating configuration (IOC) of the station. The ASEB has reconstituted the ad hoc committee which then established panels to address each specific related subject. The participants of the panels come from the committee, industry, and universities. The proceedings of the Panel on In Space Engineering Research and Technology Development are presented in this report. Activities, and plans for identifying and developing R&T programs to be conducted by the space station and related in space support needs including module requirements are addressed. Consideration is given to use of the station for R&T for other government agencies, universities, and industry.

Massachusetts Institute of Technology Clean Energy Entrepreneurship Prize 2008 Final Report DOE Award # DE-FG36-07GO17110

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2008-08-09

The MIT Clean Energy Prize was established to accelerate the pace of innovation in the energy space, specifically with regard to clean energy and to reduce our dependence on foreign oil. Through a prize structure designed to incent new ideas to be brought forward coupled with a supporting infrastructure to educate, mentor, network and provide a platform for visibility, it was believed we could achieve this goal in a very efficient and effective manner. The grand prize of $200K was meant to be the highly visible and attractive carrot to achieve this and through a public-private partnership of sponsors whomore » held a long term view (i.e., they were not Venture Capitalists or law firms looking for short term business through advantaged deal flow). It was also designed to achieve this in a highly inclusive manner. Towards this end, while MIT was the platform on which the competition was run, and this brought some instant cache and differentiation, the competition was open to all teams which had at least one US citizen. Both professional teams and student teams were eligible.« less

Finding Multi-scale Connectivity in Our Geospace Observational System: A New Perspective for Total Electron Content Data Through Network Analysis

NASA Astrophysics Data System (ADS)

McGranaghan, R. M.; Mannucci, A. J.; Verkhoglyadova, O. P.; Malik, N.

2017-12-01

How do we evolve beyond current traditional methods in order to innovate into the future? In what disruptive innovations will the next frontier of space physics and aeronomy (SPA) be grounded? We believe the answer to these compelling, yet equally challenging, questions lies in a shift of focus: from a narrow, field-specific view to a radically inclusive, interdisciplinary new modus operandi at the intersection of SPA and the information and data sciences. Concretely addressing these broader themes, we present results from a novel technique for knowledge discovery in the magnetosphere-ionosphere-thermosphere (MIT) system: complex network analysis (NA). We share findings from the first NA of ionospheric total electron content (TEC) data, including hemispheric and interplanetary magnetic field clock angle dependencies [1]. Our work shows that NA complements more traditional approaches for the investigation of TEC structure and dynamics, by both reaffirming well-established understanding, giving credence to the method, and identifying new connections, illustrating the exciting potential. We contextualize these new results through a discussion of the potential of data-driven discovery in the MIT system when innovative data science techniques are embraced. We address implications and potentially disruptive data analysis approaches for SPA in terms of: 1) the future of the geospace observational system; 2) understanding multi-scale phenomena; and 3) machine learning. [1] McGranaghan, R. M., A. J. Mannucci, O. Verkhoglyadova, and N. Malik (2017), Finding multiscale connectivity in our geospace observational system: Network analysis of total electron content, J. Geophys. Res. Space Physics, 122, doi:10.1002/2017JA024202.

Novel gene fusion of PRCC-MITF defines a new member of MiT family translocation renal cell carcinoma: clinicopathological analysis and detection of the gene fusion by RNA sequencing and FISH.

PubMed

Xia, Qiu-Yuan; Wang, Xiao-Tong; Ye, Sheng-Bing; Wang, Xuan; Li, Rui; Shi, Shan-Shan; Fang, Ru; Zhang, Ru-Song; Ma, Heng-Hui; Lu, Zhen-Feng; Shen, Qin; Bao, Wei; Zhou, Xiao-Jun; Rao, Qiu

2018-04-01

MITF, TFE3, TFEB and TFEC belong to the same microphthalmia-associated transcription factor family (MiT). Two transcription factors in this family have been identified in two unusual types of renal cell carcinoma (RCC): Xp11 translocation RCC harbouring TFE3 gene fusions and t(6;11) RCC harbouring a MALAT1-TFEB gene fusion. The 2016 World Health Organisation classification of renal neoplasia grouped these two neoplasms together under the category of MiT family translocation RCC. RCCs associated with the other two MiT family members, MITF and TFEC, have rarely been reported. Herein, we identify a case of MITF translocation RCC with the novel PRCC-MITF gene fusion by RNA sequencing. Histological examination of the present tumour showed typical features of MiT family translocation RCCs, overlapping with Xp11 translocation RCC and t(6;11) RCC. However, this tumour showed negative results in TFE3 and TFEB immunochemistry and split fluorescence in-situ hybridisation (FISH) assays. The other MiT family members, MITF and TFEC, were tested further immunochemically and also showed negative results. RNA sequencing and reverse transcription-polymerase chain reaction confirmed the presence of a PRCC-MITF gene fusion: a fusion of PRCC exon 5 to MITF exon 4. We then developed FISH assays covering MITF break-apart probes and PRCC-MITF fusion probes to detect the MITF gene rearrangement. This study both proves the recurring existence of MITF translocation RCC and expands the genotype spectrum of MiT family translocation RCCs. © 2017 John Wiley & Sons Ltd.

Umgang mit Antithrombotika bei Operationen an der Haut vor und nach Publikation der entsprechenden S3-Leitlinie.

PubMed

Gaskins, Matthew; Dittmann, Martin; Eisert, Lisa; Werner, Ricardo Niklas; Dressler, Corinna; Löser, Christoph; Nast, Alexander

2018-03-01

Laut einer Befragung im Jahre 2012 war der Umgang mit Antithrombotika bei dermatochirurgischen Eingriffen in Deutschland sehr heterogen. 2014 wurde erstmals eine evidenzbasierte Leitlinie zu diesem Thema veröffentlicht. Es wurde eine anonyme Befragung derselben Stichprobe zum Umgang mit Antithrombotika sowie zu Kenntnissen der Leitlinie durchgeführt. Die Ergebnisse wurden als relative Häufigkeiten berichtet und denen aus 2012 gegenübergestellt. 208 Antwortbögen wurden ausgewertet (Rücklaufquote: 36,6 %). Die große Mehrheit der Dermatologen erklärte, kleinere Eingriffe unter Fortführung der Therapie mit Phenprocoumon, niedrig dosierter Acetylsalicylsäure (≤ 100 mg) und Clopidogrel sowie mit direkten oralen Antikoagulanzien durchzuführen. Bei größeren Eingriffen war der Umgang hingegen weiterhin heterogen, insbesondere unter niedergelassenen Dermatologen. Der Anteil der Dermatologen, die Phenprocoumon, Acetylsalicylsäure und Clopidogrel leitlinienkonform verwendeten, hat sich insgesamt vergrößert. Führten 2012 beispielsweise 53,8 % der Klinikärzte bzw. 36,3 % der niedergelassenen Dermatologen eine große Exzision unter Fortführung der Therapie mit niedrig dosierter Acetylsalicylsäure durch, taten dies 2017 90,2 % bzw. 57,8 % (Phenprocoumon: 33,8 % bzw. 11,9 % auf 63,9 % bzw. 29,9 %; Clopidogrel: 36,9 % bzw. 23,2 % auf 63,9 % bzw. 30,6 %). Unter den Klinikärzten war ein hoher Anteil mit der Leitlinie vertraut und fand diese hilfreich. Eine Zunahme des leitlinienkonformen Verhaltens war bei allen Eingriffen zu verzeichnen. Bei größeren Eingriffen zeigte sich trotz deutlicher Verbesserung die Notwendigkeit verstärkter Anstrengungen zur Leitlinienumsetzung bzw. zur Identifizierung von Implementierungsbarrieren. © 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Alteration of the brain morphology and the response to the acute stress in the recombinant mouse lines with different predisposition to catalepsy.

PubMed

Kulikova, E A; Bazovkina, D V; Antonov, Y V; Akulov, A E; Kulikov, A V; Kondaurova, E M

2017-04-01

Catalepsy is an inability to correct an externally imposed awkward posture; it is associated with schizophrenia and depression in human. We created new recombinant B6.CBA-D13Mit76C and B6.CBA-D13Mit76B mouse lines on the C57Bl/6 genome, carrying the 102.73-110.56Mbp fragment of chromosome 13 derived from the catalepsy-prone CBA strain and catalepsy-resistant C57BL/6 strain, respectively. We compared the behavior and brain morphology (11.7T BioSpec 117/16 USR tomograph, Germany) in these lines. The effects of acute emotional stress on corticosterone's level in the blood and mRNA expression of Bdnf and Arc genes in the brain were investigated. The B6.CBA-D13Mit76B mice were non-cataleptic, while about 17% of B6.CBA-D13Mit76C mice demonstrated catalepsy-like immobility. No difference between these lines was revealed in the open field and social interaction tests. In the Morris water maze test, both lines effectively found the platform on the fourth day; however B6.CBA-D13Mit76B mice achieved significantly better results than cataleptic-prone animals. B6.CBA-D13Mit76C mice were characterized by decreased volume of the total brain and reduced sizes of striatum, cerebellum and pituitary gland. The both lines showed the similar basal and stress-induced levels of corticosterone, while the brain expression of Bdnf and Arc genes was more vulnerable to stress in the catalepsy-prone B6.CBA-D13Mit76C line. Copyright © 2016 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.

Minimally invasive, nonendoscopic thyroidectomy: a cosmetic alternative to robotic-assisted thyroidectomy.

PubMed

Govednik, Cara M; Snyder, Samuel K; Quinn, Courtney E; Saxena, Saurabh; Jupiter, Daniel C

2014-10-01

The desire to improve cosmesis has driven the introduction of robotic-assisted and video-assisted thyroidectomy techniques. We report on minimally invasive thyroidectomy (MIT) through a 2-cm incision without the added need for video assistance and hypothesize similar clinical results to standard open thyroidectomy. Between May 2012 and December 2013, 62 nonendoscopic MIT were evaluated for demographics, clinical outcomes, and patient satisfaction on a 1-10 scale. The results were compared with a case-matched control group who underwent conventional open thyroidectomy by the same surgeon. The 124 study patients demonstrated no differences between groups for demographics or clinical outcomes except a smaller thyroid lobe in the MIT group (9.2 vs 11.7 g; P = .05). There were longer operative times in the MIT group (135.4 vs 119.6 minutes; P = .07) that were not equivalent by equivalence testing (P = .534). In MIT patients, transient recurrent laryngeal nerve injury occurred per nerves at risk (1.1% vs 3.4%; P = .62) with no permanent injuries in either group. There was no difference in symptomatic hypocalcemia (9.7% vs 11.3%; P = .77) and postoperative hematoma (0% vs 3.2%; P = .50). On follow-up, the measured MIT scar was significantly shorter (2.22 vs 3.98 cm; P < .00001), which resulted in significantly improved cosmetic satisfaction ratings (9.56 vs 8.66; P = .03). In selected patients, MIT through a 2-cm incision without endoscopic assistance is a safe alternative to standard open thyroidectomy in the hands of an experienced endocrine surgeon. The operating time is slightly increased, but clinical results are equivalent and patient satisfaction is significantly improved. Copyright © 2014 Elsevier Inc. All rights reserved.

Interactions of the Human LIP5 Regulatory Protein with Endosomal Sorting Complexes Required for Transport*♦

PubMed Central

Skalicky, Jack J.; Arii, Jun; Wenzel, Dawn M.; Stubblefield, William-May B.; Katsuyama, Angela; Uter, Nathan T.; Bajorek, Monika; Myszka, David G.; Sundquist, Wesley I.

2012-01-01

The endosomal sorting complex required for transport (ESCRT) pathway remodels membranes during multivesicular body biogenesis, the abscission stage of cytokinesis, and enveloped virus budding. The ESCRT-III and VPS4 ATPase complexes catalyze the membrane fission events associated with these processes, and the LIP5 protein helps regulate their interactions by binding directly to a subset of ESCRT-III proteins and to VPS4. We have investigated the biochemical and structural basis for different LIP5-ligand interactions and show that the first microtubule-interacting and trafficking (MIT) module of the tandem LIP5 MIT domain binds CHMP1B (and other ESCRT-III proteins) through canonical type 1 MIT-interacting motif (MIM1) interactions. In contrast, the second LIP5 MIT module binds with unusually high affinity to a novel MIM element within the ESCRT-III protein CHMP5. A solution structure of the relevant LIP5-CHMP5 complex reveals that CHMP5 helices 5 and 6 and adjacent linkers form an amphipathic “leucine collar” that wraps almost completely around the second LIP5 MIT module but makes only limited contacts with the first MIT module. LIP5 binds MIM1-containing ESCRT-III proteins and CHMP5 and VPS4 ligands independently in vitro, but these interactions are coupled within cells because formation of stable VPS4 complexes with both LIP5 and CHMP5 requires LIP5 to bind both a MIM1-containing ESCRT-III protein and CHMP5. Our studies thus reveal how the tandem MIT domain of LIP5 binds different types of ESCRT-III proteins, promoting assembly of active VPS4 enzymes on the polymeric ESCRT-III substrate. PMID:23105106

Technology transfer: The key to successful space engineering education

NASA Astrophysics Data System (ADS)

Fletcher, L. S.; Page, R. H.

The 1990s are the threshold of the space revolution for the next century. This space revolution was initiated by space pioneers like Tsiolkovsky, Goddard, and Oberth, who contributed a great deal to the evolution of space exploration, and more importantly, to space education. Recently, space engineering education programs for all ages have been advocated around the world, especially in Asia and Europe, as well as the U.S.A. and the Soviet Union. And yet, although space related technologies are developing rapidly, these technologies are not being incorporated successfully into space education programs. Timely technology transfer is essential to assure the continued education of professionals. This paper reviews the evolution of space engineering education and identifies a number of initiatives which could strengthen space engineering education for the next century.

The knockdown of OsVIT2 and MIT affects iron localization in rice seed.

PubMed

Bashir, Khurram; Takahashi, Ryuichi; Akhtar, Shamim; Ishimaru, Yasuhiro; Nakanishi, Hiromi; Nishizawa, Naoko K

2013-11-20

The mechanism of iron (Fe) uptake in plants has been extensively characterized, but little is known about how Fe transport to different subcellular compartments affects Fe localization in rice seed. Here, we discuss the characterization of a rice vacuolar Fe transporter 2 (OsVIT2) T-DNA insertion line (osvit2) and report that the knockdown of OsVIT2 and mitochondrial Fe transporter (MIT) expression affects seed Fe localization. osvit2 plants accumulated less Fe in their shoots when grown under normal or excess Fe conditions, while the accumulation of Fe was comparable to that in wild-type (WT) plants under Fe-deficient conditions. The accumulation of zinc, copper, and manganese also changed significantly in the shoots of osvit2 plants. The growth of osvit2 plants was also slow compared to that of WT plants. The concentration of Fe increased in osvit2 polished seeds. Previously, we reported that the expression of OsVIT2 was higher in MIT knockdown (mit-2) plants, and in this study, the accumulation of Fe in mit-2 seeds decreased significantly. These results suggest that vacuolar Fe trafficking is important for plant Fe homeostasis and distribution, especially in plants grown in the presence of excess Fe. Moreover, changes in the expression of OsVIT2 and MIT affect the concentration and localization of metals in brown rice as well as in polished rice seeds.

Composition dependence of charge and magnetic length scales in mixed valence manganite thin films

PubMed Central

Singh, Surendra; Freeland, J. W.; Fitzsimmons, M. R.; Jeen, H.; Biswas, A.

2016-01-01

Mixed-valence manganese oxides present striking properties like the colossal magnetoresistance, metal-insulator transition (MIT) that may result from coexistence of ferromagnetic, metallic and insulating phases. Percolation of such phase coexistence in the vicinity of MIT leads to first-order transition in these manganites. However the length scales over which the electronic and magnetic phases are separated across MIT which appears compelling for bulk systems has been elusive in (La1−yPry)1−xCaxMnO3 films. Here we show the in-plane length scale over which charge and magnetism are correlated in (La0.4Pr0.6)1−xCaxMnO3 films with x = 0.33 and 0.375, across the MIT temperature. We combine electrical transport (resistance) measurements, x-ray absorption spectroscopy (XAS), x-ray magnetic circular dichroism (XMCD), and specular/off-specular x-ray resonant magnetic scattering (XRMS) measurements as a function of temperature to elucidate relationships between electronic, magnetic and morphological structure of the thin films. Using off-specular XRMS we obtained the charge-charge and charge-magnetic correlation length of these LPCMO films across the MIT. We observed different charge-magnetic correlation length for two films which increases below the MIT. The different correlation length shown by two films may be responsible for different macroscopic (transport and magnetic) properties. PMID:27461993

Composition dependence of electronic, magnetic, transport and morphological properties of mixed valence manganite thin films

DOE PAGES

Singh, Surendra; Freeland, J. W.; Fitzsimmons, Michael R.; ...

2016-07-27

Mixed-valence manganese oxides present striking properties like the colossal magnetoresistance, metal-insulator transition (MIT) that may result from coexistence of ferromagnetic, metallic and insulating phases. Percolation of such phase coexistence in the vicinity of MIT leads to first-order transition in these manganites. However the length scales over which the electronic and magnetic phases are separated across MIT which appears compelling for bulk systems has been elusive in (La 1-yPr y) 1-xCaxMnO 3 films. Here we show the in-plane length scale over which charge and magnetism are correlated in (La 0.4Pr 0.6) 1-xCaxMnO3 films with x = 0.33 and 0.375, across themore » MIT temperature. We combine electrical transport (resistance) measurements, x-ray absorption spectroscopy (XAS), x-ray magnetic circular dichroism (XMCD), and specular/off-specular x-ray resonant magnetic scattering (XRMS) measurements as a function of temperature to elucidate relationships between electronic, magnetic and morphological structure of the thin films. Using off-specular XRMS we obtained the charge-charge and charge-magnetic correlation length of these LPCMO films across the MIT. We observed different charge-magnetic correlation length for two films which increases below the MIT. The different correlation length shown by two films may be responsible for different macroscopic (transport and magnetic) properties.« less

Global Space Weather Observational Network: Challenges and China's Contribution

NASA Astrophysics Data System (ADS)

Wang, C.

2017-12-01

To understand space weather physical processes and predict space weather accurately, global space-borne and ground-based space weather observational network, making simultaneous observations from the Sun to geo-space (magnetosphere, ionosphere and atmosphere), plays an essential role. In this talk, we will present the advances of the Chinese space weather science missions, including the ASO-S (Advanced Space-borne Solar Observatory), MIT (Magnetosphere - Ionosphere- Thermosphere Coupling Exploration), and the ESA-China joint space weather science mission SMILE (Solar wind - Magnetosphere - Ionosphere Link Explore), a new mission to image the magnetosphere. Compared to satellites, ground-based monitors are cheap, convenient, and provide continuous real-time data. We will also introduce the Chinese Meridian Project (CMP), a ground-based program fully utilizing the geographic location of the Chinese landmass to monitor the geo-space environment. CMP is just one arm of a larger program that Chinese scientists are proposing to the international community. The International Meridian Circle Program (IMCP) for space weather hopes to connect chains of ground-based monitors at the longitudinal meridians 120 deg E and 60 deg W. IMCP takes advantage of the fact that these meridians already have the most monitors of any on Earth, with monitors in Russia, Australia, Brazil, the United States, Canada, and other countries. This data will greatly enhance the ability of scientists to monitor and predict the space weather worldwide.

Component improvement of free-piston Stirling engine key technology for space power

NASA Technical Reports Server (NTRS)

Alger, Donald L.

1988-01-01

The successful performance of the 25 kW Space Power Demonstrator (SPD) engine during an extensive testing period has provided a baseline of free piston Stirling engine technology from which future space Stirling engines may evolve. Much of the success of the engine was due to the initial careful selection of engine materials, fabrication and joining processes, and inspection procedures. Resolution of the few SPD engine problem areas that did occur has resulted in the technological advancement of certain key free piston Stirling engine components. Derivation of two half-SPD, single piston engines from the axially opposed piston SPD engine, designated as Space Power Research (SPR) engines, has made possible the continued improvement of these engine components. The two SPR engines serve as test bed engines for testing of engine components. Some important fabrication and joining processes are reviewed. Also, some component deficiencies that were discovered during SPD engine testing are described and approaches that were taken to correct these deficiencies are discussed. Potential component design modifications, based upon the SPD and SPR engine testing, are also reported.

Sculpting in cyberspace: Parallel processing the development of new software

NASA Technical Reports Server (NTRS)

Fisher, Rob

1993-01-01

Stimulating creativity in problem solving, particularly where software development is involved, is applicable to many disciplines. Metaphorical thinking keeps the problem in focus but in a different light, jarring people out of their mental ruts and sparking fresh insights. It forces the mind to stretch to find patterns between dissimilar concepts, in the hope of discovering unusual ideas in odd associations (Technology Review January 1993, p. 37). With a background in Engineering and Visual Design from MIT, I have for the past 30 years pursued a career as a sculptor of interdisciplinary monumental artworks that bridge the fields of science, engineering and art. Since 1979, I have pioneered the application of computer simulation to solve the complex problems associated with these projects. A recent project for the roof of the Carnegie Science Center in Pittsburgh made particular use of the metaphoric creativity technique described above. The problem-solving process led to the creation of hybrid software combining scientific, architectural and engineering visualization techniques. David Steich, a Doctoral Candidate in Electrical Engineering at Penn State, was commissioned to develop special software that enabled me to create innovative free-form sculpture. This paper explores the process of inventing the software through a detailed analysis of the interaction between an artist and a computer programmer.

Reisen im freien Fall - Teil 2: Das Zwillingsparadoxon aus dem Blickwinkel der ART

NASA Astrophysics Data System (ADS)

Sonne, Bernd; Weiß, Reinhard

2013-07-01

Nachdem wir uns mit den Prinzipien der ART und einigen Beispielen vertraut gemacht haben, kommen wir nun zur Berechnung des Zwillingsparadoxons aus Sicht des reisenden Zwillings. Dabei spielt das Äquivalenzprinzip eine große Rolle. Deshalb wird die Bewegungssituation noch einmal erläutert, diesmal aus Sicht von Katrin. Sie befindet sich in ihrem System S'in Ruhe. In ihrem System läuft die Zeit t'ab. Nach dem Start fühlt Katrin jedoch eine Kraft, die sie als Gravitationskraft interpretieren kann. Sie merkt es daran, dass sie in den Sitz gedrückt wird. Nach einiger Zeit werden die Triebwerke abgeschaltet, und das Raumschiff fliegt mit konstanter Geschwindigkeit weiter, Phase 2. Anschließend wird der Schub der Triebwerke solange umgekehrt, bis das Raumschiff irgendwo mit der Geschwindigkeit null am Umkehrpunkt U landet, Phase 3 (Abb. 15.1). Die Erde, auf der sich Michael befindet, bewegt sich mit x'(t') aus Sicht von Katrin im freien Fall von ihr weg, s. das Experiment mit dem steigenden Fahrstuhl in Abschn. 13.2.1.

The Development and Validation of the Mood-based Indoor Tanning Scale.

PubMed

Carcioppolo, Nick; Chen, Yixin; John, Kevin K; Gonzalez, Andrea Martinez; King, Andy J; Morgan, Susan E; Hu, Shasa

2017-01-01

Research indicates that mood-based motivations may be an important predictor of indoor tanning bed use and may be related to indoor tanning dependence. Problematically, little research has been conducted to develop a psychometric measure of mood-based tanning motivations. The current study seeks to develop and validate the moodbased indoor tanning scale (MITS). Two studies were conducted to identify and verify the MITS factor structure as well as assess construct validity. Study 1 was conducted at 5 geographically diverse universities in the United States. Study 2 was conducted by using a national online sample in the United States. Results from study 1 specified the factor structure of the MITS. Results from study 2 suggest that a one-point increase in the MITS measure corresponds with using indoor tanning beds 11 more times in the past year. These findings demonstrate that moodbased tanning motivations are a strong predictor of indoor tanning intentions and behavior. Further, they suggest that health behavior researchers and healthcare practitioners can use the MITS to assess the extent to which mood-based motivations impact indoor tanning bed use.

Space Shuttle Project

NASA Image and Video Library

1981-01-01

A Space Shuttle Main Engine undergoes test-firing at the National Space Technology Laboratories (now the Sternis Space Center) in Mississippi. The Marshall Space Flight Center had management responsibility of Space Shuttle propulsion elements, including the Main Engines.

MIT-NASA Workshop: Transformational Technologies

NASA Technical Reports Server (NTRS)

Mankins, J. C. (Editor); Christensen, C. B.; Gresham, E. C.; Simmons, A.; Mullins, C. A.

2005-01-01

As a space faring nation, we are at a critical juncture in the evolution of space exploration. NASA has announced its Vision for Space Exploration, a vision of returning humans to the Moon, sending robots and eventually humans to Mars, and exploring the outer solar system via automated spacecraft. However, mission concepts have become increasingly complex, with the potential to yield a wealth of scientific knowledge. Meanwhile, there are significant resource challenges to be met. Launch costs remain a barrier to routine space flight; the ever-changing fiscal and political environments can wreak havoc on mission planning; and technologies are constantly improving, and systems that were state of the art when a program began can quickly become outmoded before a mission is even launched. This Conference Publication describes the workshop and featured presentations by world-class experts presenting leading-edge technologies and applications in the areas of power and propulsion; communications; automation, robotics, computing, and intelligent systems; and transformational techniques for space activities. Workshops such as this one provide an excellent medium for capturing the broadest possible array of insights and expertise, learning from researchers in universities, national laboratories, NASA field Centers, and industry to help better our future in space.

KSC-2012-1025

NASA Image and Video Library

2012-01-12

CAPE CANAVERAL, Fla. – In the Space Shuttle Main Engine Processing Facility at NASA’s Kennedy Space Center in Florida, a technician oversees the closure of a transportation canister containing a Pratt Whitney Rocketdyne space shuttle main engine (SSME). This is the second of the 15 engines used during the Space Shuttle Program to be prepared for transfer to NASA's Stennis Space Center in Mississippi. The engines will be stored at Stennis for future use on NASA's new heavy-lift rocket, the Space Launch System (SLS), which will carry NASA's new Orion spacecraft, cargo, equipment and science experiments to space. For more information, visit http://www.nasa.gov/shuttle. Photo credit: NASA/Gianni Woods

KSC-2011-6523

NASA Image and Video Library

2011-08-19

CAPE CANAVERAL, Fla. -- In Orbiter Processing Facility-2 at NASA’s Kennedy Space Center in Florida, technicians monitor the progress as they use a Hyster forklift to position an engine removal device on Engine #3 on space shuttle Atlantis. Inside the aft section, a technician disconnects hydraulic, fluid and electrical lines. The forklift will be used to remove the engine and transport it to the Engine Shop for possible future use. Each of the three space shuttle main engines is 14 feet long and weighs 7,800 pounds. Removal of the space shuttle main engines is part of the Transition and Retirement work that is being performed in order to prepare Atlantis for eventual display at the Kennedy Space Center Visitor Complex in Florida. Photo credit: Frankie Martin

Magnetosphere - Ionosphere - Thermosphere (MIT) Coupling at Jupiter

NASA Astrophysics Data System (ADS)

Yates, J. N.; Ray, L. C.; Achilleos, N.

2017-12-01

Jupiter's upper atmospheric temperature is considerably higher than that predicted by Solar Extreme Ultraviolet (EUV) heating alone. Simulations incorporating magnetosphere-ionosphere coupling effects into general circulation models have, to date, struggled to reproduce the observed atmospheric temperatures under simplifying assumptions such as azimuthal symmetry and a spin-aligned dipole magnetic field. Here we present the development of a full three-dimensional thermosphere model coupled in both hemispheres to an axisymmetric magnetosphere model. This new coupled model is based on the two-dimensional MIT model presented in Yates et al., 2014. This coupled model is a critical step towards to the development of a fully coupled 3D MIT model. We discuss and compare the resulting thermospheric flows, energy balance and MI coupling currents to those presented in previous 2D MIT models.

Engineering Research and Technology Development on the Space Station

NASA Technical Reports Server (NTRS)

1996-01-01

This report identifies and assesses the kinds of engineering research and technology development applicable to national, NASA, and commercial needs that can appropriately be performed on the space station. It also identifies the types of instrumentation that should be included in the space station design to support engineering research. The report contains a preliminary assessment of the potential benefits to U.S. competitiveness of engineering research that might be conducted on a space station, reviews NASA's current approach to jointly funded or cooperative experiments, and suggests modifications that might facilitate university and industry participation in engineering research and technology development activities on the space station.

Final RS-25 Engine Test of the Summer

NASA Image and Video Library

2017-08-30

On Aug. 30, engineers at our Stennis Space Center wrapped up a summer of hot fire testing for flight controllers on RS-25 engines that will help power the new Space Launch System rocket being built to carry astronauts to deep-space destinations, including Mars. The 500-second hot fire of a flight controller or “brain” of the engine marked another step toward the nation’s return to human deep-space exploration missions. Four RS-25 engines, equipped with flight-worthy controllers will help power the first integrated flight of our Space Launch System rocket with our Orion spacecraft, known as Exploration Mission One.

46 CFR 182.465 - Ventilation of spaces containing diesel machinery.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Ventilation of spaces containing diesel machinery. 182... Ventilation of spaces containing diesel machinery. (a) A space containing diesel machinery must be fitted with... operation of main engines and auxiliary engines. (b) Air-cooled propulsion and auxiliary diesel engines...

46 CFR 182.465 - Ventilation of spaces containing diesel machinery.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Ventilation of spaces containing diesel machinery. 182... Ventilation of spaces containing diesel machinery. (a) A space containing diesel machinery must be fitted with... operation of main engines and auxiliary engines. (b) Air-cooled propulsion and auxiliary diesel engines...

NASA Tests RS-25 Flight Engine for Space Launch System

NASA Image and Video Library

2017-10-19

Engineers at NASA’s Stennis Space Center in Mississippi on Oct. 19 completed a hot-fire test of RS-25 rocket engine E2063, a flight engine for NASA’s new Space Launch System (SLS) rocket. Engine E2063 is scheduled to help power SLS on its Exploration Mission-2 (EM-2), the first flight of the new rocket to carry humans.

High frequency data acquisition system for space shuttle main engine testing

NASA Technical Reports Server (NTRS)

Lewallen, Pat

1987-01-01

The high frequency data acquisition system developed for the Space Shuttle Main Engine (SSME) single engine test facility at the National Space Technology Laboratories is discussed. The real time system will provide engineering data for a complete set of SSME instrumentation (approx. 100 measurements) within 4 hours following engine cutoff, a decrease of over 48 hours from the previous analog tape based system.

J-2X engine

NASA Image and Video Library

2012-05-16

On May 16, 2012, engineers at Stennis Space Center conducted a test of the next-generation J-2X engine that will help power NASA's new Space Launch System, moving NASA even closer to a return to deep space.

NASA Tests 2nd RS-25 Flight Engine for Space Launch System

NASA Image and Video Library

2018-01-16

On Jan. 16, 2018, engineers at NASA’s Stennis Space Center in Mississippi conducted a certification test of another RS-25 engine flight controller on the A-1 Test Stand at Stennis Space Center. The 365-second, full-duration test came a month after the space agency capped a year of RS-25 testing with a flight controller test in mid-December. For the “green run” test the flight controller was installed on RS-25 developmental engine E0528 and fired just as during an actual launch. Once certified, the flight controller will be removed and installed on a flight engine for use by NASA’s new deep-space rocket, the Space Launch System (SLS).

MIT ASTROMAG 1.7 meter disk magnet design report

NASA Technical Reports Server (NTRS)

Marston, P. G.; Hale, J. R.; Vieira, R.; Zhukovsky, A.; Titus, P. H.; Sullivan, J. D.; Dawson, A. M.

1990-01-01

MIT has proposed a magnet design for ASTROMAG, which has demonstrated substantial improvement in performance as compared with the present HEAO baseline design. Several advantages of the MIT disk design are listed along with design characteristics. Details of field contours and active field regions are shown along with comparisons with other designs. Three alternative design configurations for the ASTROMAG disk coils are summarized. The parameters of the conductors are listed and basic parameters for each of the complete systems are shown.

Wake Turbulence Mitigation for Departures (WTMD) Prototype System - Software Design Document

NASA Technical Reports Server (NTRS)

Sturdy, James L.

2008-01-01

This document describes the software design of a prototype Wake Turbulence Mitigation for Departures (WTMD) system that was evaluated in shadow mode operation at the Saint Louis (KSTL) and Houston (KIAH) airports. This document describes the software that provides the system framework, communications, user displays, and hosts the Wind Forecasting Algorithm (WFA) software developed by the M.I.T. Lincoln Laboratory (MIT-LL). The WFA algorithms and software are described in a separate document produced by MIT-LL.

Intelligence in the Now: Robust Intelligence in Complex Domains

DTIC Science & Technology

2015-09-26

We have applied our model and the resulting search strategy for a mobile manipulator modeled on a Willow Garage PR2 robot. As shown in Figure 12...with them – the robot tries to move a handle to various target locations and observes the reached location. Figure 13 shows Willow Garage PR2 robot...Massachusetts Institute of Technology, Cambridge, MA 02139 USA barragan@mit.edu, tlp@mit.edu, lpk@mit.edu Fig. 1. Willow Garage PR2 robot manipulating

The role of the University Licensing Office in transferring intellectual property to industry

NASA Technical Reports Server (NTRS)

Preston, John T.

1992-01-01

Universities in the US have a significant impact on business through the transfer of technology. This transfer of technology takes various forms, including faculty communications, faculty consulting activities, and the direct transfer of technology through the licensing of patents, copyrights, and other intellectual property to industry. The topics discussed include the following: background of the MIT Technology Licensing Office (TLO), goals of the MIT TLO, MIT's technology transfer philosophy, and important factors for success in new company formation.

1st SSME test of 2006

NASA Image and Video Library

2006-01-09

Water vapor surges from the flame deflector of the A-2 Test Stand at NASA's Stennis Space Center on Jan. 9 during the first space shuttle main engine test of the year. The test was an engine acceptance test of flight engine 2058. It's the first space shuttle main engine to be completely assembled at Kennedy Space Center. Objectives also included first-time (green run) tests of a high-pressure oxidizer turbo pump and an Advanced Health System Monitor engine controller. The test ran for the planned duration of 520 seconds.

RS-25 engine

NASA Image and Video Library

2012-04-10

RS-25 series rocket engine No. 2059 is unloaded and positioned at Stennis Space Center on April 10, 2012, for future testing and use on NASA's new Space Launch System. The engine was the last of 15 RS-25 engines to be delivered from NASA's Kennedy Space Center in Florida to Stennis, where all will be stored until testing begins.

En route Spacing Tool: Efficient Conflict-free Spacing to Flow-Restricted Airspace

NASA Technical Reports Server (NTRS)

Green, S.

1999-01-01

This paper describes the Air Traffic Management (ATM) problem within the U.S. of flow-restricted en route airspace, an assessment of its impact on airspace users, and a set of near-term tools and procedures to resolve the problem. The FAA is committed, over the next few years, to deploy the first generation of modem ATM decision support tool (DST) technology under the Free-Flight Phase-1 (FFp1) program. The associated en route tools include the User Request Evaluation Tool (URET) and the Traffic Management Advisor (TMA). URET is an initial conflict probe (ICP) capability that assists controllers with the detection and resolution of conflicts in en route airspace. TMA orchestrates arrivals transitioning into high-density terminal airspace by providing controllers with scheduled times of arrival (STA) and delay feedback advisories to assist with STA conformance. However, these FFPl capabilities do not mitigate the en route Miles-In-Trail (MIT) restrictions that are dynamically applied to mitigate airspace congestion. National statistics indicate that en route facilities (Centers) apply Miles-In-Trail (MIT) restrictions for approximately 5000 hours per month. Based on results from this study, an estimated 45,000 flights are impacted by these restrictions each month. Current-day practices for implementing these restrictions result in additional controller workload and an economic impact of which the fuel penalty alone may approach several hundred dollars per flight. To mitigate much of the impact of these restrictions on users and controller workload, a DST and procedures are presented. The DST is based on a simple derivative of FFP1 technology that is designed to introduce a set of simple tools for flow-rate (spacing) conformance and integrate them with conflict-probe capabilities. The tool and associated algorithms are described based on a concept prototype implemented within the CTAS baseline in 1995. A traffic scenario is used to illustrate the controller's use of the tool, and potential display options are presented for future controller evaluation.

Authentic teaching and learning through synthetic biology

PubMed Central

Kuldell, Natalie

2007-01-01

Synthetic biology is an emerging engineering discipline that, if successful, will allow well-characterized biological components to be predictably and reliably built into robust organisms that achieve specific functions. Fledgling efforts to design and implement a synthetic biology curriculum for undergraduate students have shown that the co-development of this emerging discipline and its future practitioners does not undermine learning. Rather it can serve as the lynchpin of a synthetic biology curriculum. Here I describe educational goals uniquely served by synthetic biology teaching, detail ongoing curricula development efforts at MIT, and specify particular aspects of the emerging field that must develop rapidly in order to best train the next generation of synthetic biologists. PMID:18271945

Effect of Withania somnifera on forced swimming test induced immobility in mice and its interaction with various drugs.

PubMed

Shah, P C; Trivedi, N A; Bhatt, J D; Hemavathi, K G

2006-01-01

The objective of the present study was to evaluate the antidepressant action of Withania somnifera (WS) as well as its interaction with the conventional antidepressant drugs and to delineate the possible mechanism of its antidepressant action using forced swimming model in mice. Effect of different doses of WS, fluoxetine and imipramine were studied on forced swimming test induced mean immobility time (MIT). Moreover effect of WS 100 mg/kg, i.p. was observed at different time intervals. Effect produced by combination of sub therapeutic doses of WS with imipramine (2.5 mg/kg, i.p.) as well as fluoxetine (2.5 mg/kg, i.p.) were also observed. Effect of WS (100 mg/kg, i.p.) as well as combination of WS (37.5 mg/kg, i.p.) with either imipramine (2.5 mg/kg, i.p.) or fluoxetine (2.5 mg/kg, i.p.) were observed in mice pretreated with reserpine (2 mg/kg, i.p.) and clonidine (0.15 mg/kg, i.p.). Effects of prazosin (3 mg/kg, i.p.) or haloperidol (0.1 mg/kg, i.p.) pre-treatment were also observed on WS induced decrease in MIT. WS produced dose dependent decrease in MIT. Maximum effect in MIT was observed after 30 min of treatment with WS 100 mg/kg, i.p. Combination of WS (37.5 mg/kg, i.p.) with imipramine (2.5 mg/kg, i.p.) or fluoxetine (2.5 mg/kg, i.p.) also produced significant decrease in the MIT. Clonidine and reserpine induced increase in MIT, was significantly reversed by treatment with WS (100 mg/kg, i.p.) as well as combination of WS (37.5 mg/kg, i.p.) with either imipramine (2.5 mg/kg, i.p.) or fluoxetine (2.5 mg/kg, i.p.). Pre-treatment with prazosin but not haloperidol, significantly antagonized the WS (100 mg/kg, i.p.) induced decrease in MIT. It is concluded that, WS produced significant decrease in MIT in mice which could be mediated partly through a adrenoceptor as well as alteration in the level of central biogenic amines.

High Intensity Interval- vs Moderate Intensity- Training for Improving Cardiometabolic Health in Overweight or Obese Males: A Randomized Controlled Trial.

PubMed

Fisher, Gordon; Brown, Andrew W; Bohan Brown, Michelle M; Alcorn, Amy; Noles, Corey; Winwood, Leah; Resuehr, Holly; George, Brandon; Jeansonne, Madeline M; Allison, David B

2015-01-01

To compare the effects of six weeks of high intensity interval training (HIIT) vs continuous moderate intensity training (MIT) for improving body composition, insulin sensitivity (SI), blood pressure, blood lipids, and cardiovascular fitness in a cohort of sedentary overweight or obese young men. We hypothesized that HIIT would result in similar improvements in body composition, cardiovascular fitness, blood lipids, and SI as compared to the MIT group, despite requiring only one hour of activity per week compared to five hours per week for the MIT group. 28 sedentary overweight or obese men (age, 20 ± 1.5 years, body mass index 29.5 ± 3.3 kg/m2) participated in a six week exercise treatment. Participants were randomly assigned to HIIT or MIT and evaluated at baseline and post-training. DXA was used to assess body composition, graded treadmill exercise test to measure cardiovascular fitness, oral glucose tolerance to measure SI, nuclear magnetic resonance spectroscopy to assess lipoprotein particles, and automatic auscultation to measure blood pressure. A greater improvement in VO2peak was observed in MIT compared to HIIT (11.1% vs 2.83%, P = 0.0185) in the complete-case analysis. No differences were seen in the intention to treat analysis, and no other group differences were observed. Both exercise conditions were associated with temporal improvements in % body fat, total cholesterol, medium VLDL, medium HDL, triglycerides, SI, and VO2peak (P < 0.05). Participation in HIIT or MIT exercise training displayed: 1) improved SI, 2) reduced blood lipids, 3) decreased % body fat, and 4) improved cardiovascular fitness. While both exercise groups led to similar improvements for most cardiometabolic risk factors assessed, MIT led to a greater improvement in overall cardiovascular fitness. Overall, these observations suggest that a relatively short duration of either HIIT or MIT training may improve cardiometabolic risk factors in previously sedentary overweight or obese young men, with no clear advantage between these two specific regimes (Clinical Trial Registry number NCT01935323). ClinicalTrials.gov NCT01935323.

High Intensity Interval- vs Moderate Intensity- Training for Improving Cardiometabolic Health in Overweight or Obese Males: A Randomized Controlled Trial

PubMed Central

Fisher, Gordon; Brown, Andrew W.; Bohan Brown, Michelle M.; Alcorn, Amy; Noles, Corey; Winwood, Leah; Resuehr, Holly; George, Brandon; Jeansonne, Madeline M.; Allison, David B.

2015-01-01

Purpose To compare the effects of six weeks of high intensity interval training (HIIT) vs continuous moderate intensity training (MIT) for improving body composition, insulin sensitivity (SI), blood pressure, blood lipids, and cardiovascular fitness in a cohort of sedentary overweight or obese young men. We hypothesized that HIIT would result in similar improvements in body composition, cardiovascular fitness, blood lipids, and SI as compared to the MIT group, despite requiring only one hour of activity per week compared to five hours per week for the MIT group. Methods 28 sedentary overweight or obese men (age, 20 ± 1.5 years, body mass index 29.5 ± 3.3 kg/m2) participated in a six week exercise treatment. Participants were randomly assigned to HIIT or MIT and evaluated at baseline and post-training. DXA was used to assess body composition, graded treadmill exercise test to measure cardiovascular fitness, oral glucose tolerance to measure SI, nuclear magnetic resonance spectroscopy to assess lipoprotein particles, and automatic auscultation to measure blood pressure. Results A greater improvement in VO2peak was observed in MIT compared to HIIT (11.1% vs 2.83%, P = 0.0185) in the complete-case analysis. No differences were seen in the intention to treat analysis, and no other group differences were observed. Both exercise conditions were associated with temporal improvements in % body fat, total cholesterol, medium VLDL, medium HDL, triglycerides, SI, and VO2peak (P < 0.05). Conclusion Participation in HIIT or MIT exercise training displayed: 1) improved SI, 2) reduced blood lipids, 3) decreased % body fat, and 4) improved cardiovascular fitness. While both exercise groups led to similar improvements for most cardiometabolic risk factors assessed, MIT led to a greater improvement in overall cardiovascular fitness. Overall, these observations suggest that a relatively short duration of either HIIT or MIT training may improve cardiometabolic risk factors in previously sedentary overweight or obese young men, with no clear advantage between these two specific regimes (Clinical Trial Registry number NCT01935323). Trial Registration ClinicalTrials.gov NCT01935323 PMID:26489022

Return to flight SSME test at A2 test stand

NASA Image and Video Library

2004-07-16

The Space Shuttle Main Engine (SSME) reached a historic milestone July 16, 2004, when a successful flight acceptance test was conducted at NASA Stennis Space Center (SSC). The engine tested today is the first complete engine to be tested and shipped in its entirety to Kennedy Space Center for installation on Space Shuttle Discovery for STS-114, NASA's Return to Flight mission. The engine test, which began about 3:59 p.m. CDT, ran for 520 seconds (8 minutes), the length of time it takes for the Space Shuttle to reach orbit.

Fundamental Requirements on PBL Classes for Better Education

NASA Astrophysics Data System (ADS)

Ito, Teruaki

Project-Based Learning (PBL) education has become popular in the US and its educational effects have been recognized in many case studies. PBL also attracts attention of the educators in Japan, and several achievements have also been reported. However, because of its short history and its different backgrounds on the corporate sponsorship to academic institutions, implementation of PBL in engineering education has not so much been achieved well and its educational effects have not been recognized enough. This paper picks up one of the best examples of PBL class with robotic project at MIT in the US, and reviews the key factors why the class works so successfully. Comparing the review results with the experiences in the engineering class of CAD-EX at the University of Tokushima, this paper discusses the basic requirements on PBL, emphasizing the importance of strenuous efforts to encourage students towards motivated attitudes, creative learning and active participation in the class under the healthy and friendly competitive atmosphere.

Space transportation booster engine configuration study. Volume 1: Executive Summary

NASA Technical Reports Server (NTRS)

1989-01-01

The objective of the Space Transportation Booster Engine (STBE) Configuration Study is to contribute to the Advanced Launch System (ALS) development effort by providing highly reliable, low cost booster engine concepts for both expendable and reusable rocket engines. The objectives of the Space Transportation Booster Engine (STBE) Configuration Study were to identify engine configurations which enhance vehicle performance and provide operational flexibility at low cost, and to explore innovative approaches to the follow-on full-scale development (FSD) phase for the STBE.

NASA Tests 2nd RS-25 Flight Engine for Space Launch System

NASA Image and Video Library

2017-10-19

Engineers at NASA’s Stennis Space Center in Mississippi on Oct. 19 completed a hot-fire test of RS-25 rocket engine E2063, a flight engine for NASA’s new Space Launch System (SLS) rocket. Engine E2063 is scheduled to help power SLS on its Exploration Mission-2 (EM-2), the first flight of the new rocket to carry humans. Flight engine E2059 was tested on March 10, 2016, also for use on the EM-2 flight.

NASA Tests 2nd RS-25 Flight Engine For Space Launch System

NASA Image and Video Library

2017-10-19

Engineers at NASA’s Stennis Space Center in Mississippi on Oct. 19 completed a hot-fire test of RS-25 rocket engine E2063, a flight engine for NASA’s new Space Launch System (SLS) rocket. Engine E2063 is scheduled to help power SLS on its Exploration Mission-2 (EM-2), the first flight of the new rocket to carry humans. Flight engine E2059 was tested on March 10, 2016, also for use on the EM-2 flight.

Video File - NASA Tests 2nd RS-25 Flight Engine for Space Launch System

NASA Image and Video Library

2017-10-19

Engineers at NASA’s Stennis Space Center in Mississippi on Oct. 19 completed a hot-fire test of RS-25 rocket engine E2063, a flight engine for NASA’s new Space Launch System (SLS) rocket. Engine E2063 is scheduled to help power SLS on its Exploration Mission-2 (EM-2), the first flight of the new rocket to carry humans. Flight engine E2059 was tested on March 10, 2016, also for use on the EM-2 flight.

An investigation of air transportation technology at the Massachusetts Institute of Technology, 1990-1991

NASA Technical Reports Server (NTRS)

Simpson, Robert W.

1991-01-01

Brief summaries are given of research activities at the Massachusetts Institute of Technology (MIT) under the sponsorship of the FAA/NASA Joint University Program. Topics covered include hazard assessment and cockpit presentation issues for microburst alerting systems; the situational awareness effect of automated air traffic control (ATC) datalink clearance amendments; a graphical simulation system for adaptive, automated approach spacing; an expert system for temporal planning with application to runway configuration management; deterministic multi-zone ice accretion modeling; alert generation and cockpit presentation for an integrated microburst alerting system; and passive infrared ice detection for helicopter applications.

Physical Fluid Mechanics in MPD Thrusters.

DTIC Science & Technology

1987-09-18

8217 [111111 r~r.NARS ’ A nclassified ___ DOCUMENTATION PAGE Form71Approved AD-A 190 309 Y~ ~ ’’RN I1 IL *- LE:CT 3 ;S 7 ON C AvALABILITY OF REPORT 0% Approved... REPORT NUMBIER(S) MIT, Space Systems Laboratory AD AFO"R.Th. 87 -1 76 0 S 6a NAME OF PERFORMING ORGANIZATION 6bOFFICE SYMBOL 1a NAME OF MON, TORING...unclassified) 2 PERSONAL AUTHOR(S) Manuel Martinez-Sanchez - 3a TYPE OF REPORT 13b. TIM ~~D 4/30/87 14. DATE OF REPORT (Year, Month. Day) 15. PAGE

A survey of trapped low energy electrons near the inner boundary of the inner radiation zone from the OSO-7

NASA Technical Reports Server (NTRS)

Neighbours, J. E.; Clark, G. W.

1974-01-01

Data from the MIT X-ray experiment on the OSO-7 satellite were used to delineate the regions in B-L and geographic spaces where trapped radiation was encountered. The results pertain specifically to electrons with energies in a range of 10 keV centered on 55 keV which were encountered in an orbit between altitudes of 330 and 570 km and latitudes of 33.3 degrees. A typical pitch angle distribution is fitted by a Gaussian with a FWHM of 28 degrees.

Image Science Research for Speckle-based LADAR (Speckle Research for 3D Imaging LADAR)

DTIC Science & Technology

2008-04-03

INVARIANT + FERGUS, TORRALBA, AND FREEMAN. MIT-CSAIL-TR-2006-058 MAP DETECTOR PATTERN FOR EACH POINT IN OBJECT SPACE DEBLURRING PROBLEM IMPULSE RESPONSE...GENERALIZED THEORY FOR THE LOGARITHMIC ASPHERE ( )( ) it e φ ρρ −= IMPULSE RESPONSE (PSF) 2 2 2 2 0 0 22 2( ) 2 2 0 2 2 2 2 2 2 0 0 2 ( ; ) 2 ( ) i s i i t R...ascent; γ=1, Burch, Skilling, Gull; Loops needed Noise deviation Area of PSF New parameter L σ A γ COMPARISON OF MAXIMUM ENTROPY METHODS † † W. CHI

A Rainbow View of NASA's RS-25 Engine Test

NASA Image and Video Library

2017-02-22

NASA engineers conducted their first RS-25 test of 2017 on the A-1 Test Stand at Stennis Space Center near Bay St. Louis, Mississippi, on Feb. 22, continuing to collect data on the performance of the rocket engine that will help power the new Space Launch System (SLS) rocket. Shown from the viewpoint of an overhead drone, the test of development engine No. 0528 ran the scheduled 380 seconds (six minutes and 20 seconds), allowing engineers to monitor various engine operating conditions. The test represents another step forward in development of the rocket that will launch humans aboard Orion deeper into space than ever before. Four RS-25 engines, together with a pair of solid rocket boosters, will power the SLS at launch on its deep-space missions. The engines for the first four SLS flights are former space shuttle main engines, which were tested extensively at Stennis and are some of the most proven engines in the world. Engineers are conducting an ongoing series of tests this year for SLS on both development and flight engines for future flights to ensure the engine, outfitted with a new controller, can perform at the higher level under a variety of conditions and situations. Stennis is also preparing its B-2 Test Stand to test the core stage for the first SLS flight with Orion, known as Exploration Mission-1. That testing will involve installing the flight stage on the stand and firing its four RS-25 engines simultaneously, just as during an actual launch. The Feb. 22 test was conducted by Aerojet Rocketdyne and Syncom Space Services engineers and operators. Aerojet Rocketdyne is the prime contractor for the RS-25 engines. Syncom Space Services is the prime contractor for Stennis facilities and operations. PAO Name:Kim Henry Phone Number:256-544-1899 Email Address: kimberly.m.henry@nasa.gov

General view of the Space Shuttle Main Engine (SSME) assembly ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General view of the Space Shuttle Main Engine (SSME) assembly with the expansion nozzle removed and resting on a cushioned mat on the floor of the SSME Processing Facility. The most prominent features in this view are the Low-Pressure Fuel Turbopump (LPFTP) on the upper left of the engine assembly, the LPFTP Discharge Duct looping around the assembly, the Gimbal Bearing on the top center of the assembly, the Electrical Interface Panel sits just below the Gimbal Bearing and the Low-Pressure Oxidizer Turbopump is mounted on the top right of the engine assembly in this view. - Space Transportation System, Space Shuttle Main Engine, Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

MIT-CSR XIS Project

NASA Technical Reports Server (NTRS)

1998-01-01

This report outlines the proposers' progress toward MIT's contribution to the X-Ray Imaging Spectrometer (XIS) experiment on the Japanese ASTRO-E mission. The report discusses electrical system design, mechanical system design, and ground support equipment.

Qualität auf dem Prüfstand

NASA Astrophysics Data System (ADS)

Michaelis, Michael

An einem Wochenende im Dezember 2009 beendete der chinesische Eisenbahn-Vizeminister Hu Yadong in Begleitung einer hochrangigen Delegation aus Experten des Department of Safety seines Ministeriums eine mehrtägige Europareise mit einem Besuch in der Konzernzentrale des weltweit führenden Herstellers von Bremssystemen für Schienen- und Nutzfahrzeuge in München. Schon in wenigen Jahren wird China über die weltweit größte Flotte an Hochgeschwindigkeitszügen verfügen und dabei sind Sicherheit und Qualität vorrangige Anforderungen. Knorr-Bremse liefert 100% der Bremsanlagen dieser Züge und hat vor kurzem mit rund 500 Millionen Euro den größten Auftrag in der Firmengeschichte erhalten. Das Unternehmen wird zusammen mit seinen chinesischen Partnern insgesamt 2.720 neue Wagen des chinesischen Hochgeschwindigkeitszuges CRH3 mit Brems- und Türsystemen ausrüsten.

The metal-insulator transition in a phase-separated manganite studied by in situ STS

NASA Astrophysics Data System (ADS)

Snijders, P. C.; Gao, M.; Guo, H.; Ward, T. Z.; Gao, H.-J.; Shen, J.; Gai, Z.

2012-02-01

Electronic phase separation (EPS) is a key feature at the heart of the wide variety of electronic and magnetic properties in complex oxides. One consequence of EPS is that electronic transport experiments in bulk materials or 2D films mostly probe the low resistivity electronic phases due to the percolative path of the current. We study oxygen deficient La5/8-xPrxCa3/8M nO3 (LPCMO) thin films using both in situ scanning tunneling spectroscopy (STS) and ex situ transport experiments. The oxygen deficiency is known to decrease the metal-insulator transition (MIT) temperature or even completely suppress the MIT in conventional transport experiments. We show that in situ STS is able to detect the MIT even in systems where conventional transport experiments do not show an MIT at zero magnetic field.

Research Technology

NASA Image and Video Library

2002-03-11

Engineers at the Marshall Space Flight Center (MSFC) have begun a series of engine tests on a new breed of space propulsion: a Reaction Control Engine developed for the Space Launch Initiative (SLI). The engine, developed by TRW Space and Electronics of Redondo Beach, California, is an auxiliary propulsion engine designed to maneuver vehicles in orbit. It is used for docking, reentry, attitude control, and fine-pointing while the vehicle is in orbit. The engine uses nontoxic chemicals as propellants, a feature that creates a safer environment for ground operators, lowers cost, and increases efficiency with less maintenance and quicker turnaround time between missions. Testing includes 30 hot-firings. This photograph shows the first engine test performed at MSFC that includes SLI technology. Another unique feature of the Reaction Control Engine is that it operates at dual thrust modes, combining two engine functions into one engine. The engine operates at both 25 and 1,000 pounds of force, reducing overall propulsion weight and allowing vehicles to easily maneuver in space. The low-level thrust of 25 pounds of force allows the vehicle to fine-point maneuver and dock while the high-level thrust of 1,000 pounds of force is used for reentry, orbit transfer, and coarse positioning. SLI is a NASA-wide research and development program, managed by the MSFC, designed to improve safety, reliability, and cost effectiveness of space travel for second generation reusable launch vehicles.

Hepatic arterial infusion of floxuridine and dexamethasone plus high-dose Mitomycin C for patients with unresectable hepatic metastases from colorectal carcinoma.

PubMed

Kemeny, Nancy; Eid, Ahmed; Stockman, Jennifer; Gonen, Mithat; Schwartz, Lawrence; Tetzlaff, Eric; Paty, Philip

2005-08-01

In vitro data suggest increased cytotoxicity with Mitomycin C (Mit-C) and Floxuridine (FUDR). Based on these data, we performed a phase II trial of hepatic arterial infusion (HAI) of FUDR and Dexamethasone (Dex) plus high-dose Mit-C for patients with unresectable hepatic metastases from colorectal carcinoma. High-dose Mit-C (15 mg/m2) was added via the pump sideport to HAI FUDR and Dex for 14 days of a 28-day cycle. Mit-C was given on days 1 and 29, and FUDR was given indefinitely until disease progression or discontinuation of therapy due to toxicity. Sixty-three patients with unresectable liver metastases were entered. The chemotherapy-naïve group (n = 26) and those previously treated (n = 37) had similar response and median survival: 73% and 70%, and 23 and 20 months, respectively. The major toxicities were liver bilomas (7.9%), elevation in bilirubin level >3 (22%), and biliary sclerosis (9.5%). Hematologic and gastrointestinal toxicity was less than 2%. The addition of high-dose Mit-C to HAI FUDR and Dex produced a high response rate even in previously treated patients. The median survival was 21 months even though half the patients were previously treated with chemotherapy. Biliary toxicity was higher than expected; therefore, alternatives to high dose Mit-C should be investigated when exploring additions to HAI therapy with FUDR and Dex. Copyright 2005 Wiley-Liss, Inc.

Metacognitive Interpersonal Therapy in group (MIT-G) for young adults with personality disorders: A pilot randomized controlled trial.

PubMed

Popolo, Raffaele; MacBeth, Angus; Canfora, Flaviano; Rebecchi, Daniela; Toselli, Cecilia; Salvatore, Giampaolo; Dimaggio, Giancarlo

2018-04-06

Young adults with personality disorders (PD) other than borderline are in urgent need of validated treatments to help them in managing important life transitions. Therapeutic interventions focused upon social and interpersonal difficulties may facilitate these individuals in maximizing opportunities for employment, forming stable romantic relationships, and belong to social groups. It is also important that they are offered evidence-based, first-line time-limited treatments in order to maximize effectiveness and reduce costs. We developed a 16-session programme of group-based Metacognitive Interpersonal Therapy (MIT-G) including psychoeducation on the main interpersonal motives, an experiential component enabling practice of awareness of mental states; and use of mentalistic knowledge for purposeful problem-solving. We report a feasibility, acceptability, and clinical significance randomized clinical trial. Participants meeting inclusion criteria were randomized to receive MIT-G (n = 10) or waiting list+TAU (n = 10). Dropout rate was low and session attendance high (92.19%). Participants in the MIT-G arm had symptomatic and functional improvements consistent with large effect sizes. In the MIT-G arm similarly large effects were noted for increased capacity to understand mental states and regulate social interactions using mentalistic knowledge. Results were sustained at follow-up. Our findings suggest potential for applying MIT-G in larger samples to further test its effectiveness in reducing PD-related symptoms and problematic social functioning. © 2018 The British Psychological Society.

Evolution of Structural and Electrical Properties of Oxygen-Deficient VO2 under Low Temperature Heating Process.

PubMed

Zhang, Jiasong; Zhao, Zhengjing; Li, Jingbo; Jin, Haibo; Rehman, Fida; Chen, Pengwan; Jiang, Yijie; Chen, Chunxu; Cao, Maosheng; Zhao, Yongjie

2017-08-16

Structural stability and functional performances of vanadium dioxide (VO 2 ) are strongly influenced by oxygen vacancies. However, the mechanism of metal-insulator transition (MIT) influenced by defects is still under debate. Here, we study the evolution of structure and electrical property of oxygen-deficient VO 2 by a low temperature annealing process (LTP) based on a truss-structured VO 2 nanonet. The oxygenation process of the oxygen-deficient VO 2 is greatly prolonged, which enables us to probe the gradual change of properties of the oxygen-deficient VO 2 . A continuous lattice reduction is observed during LTP. No recrystallization and structural collapse of the VO 2 nanonet can be found after LTP. The valence-band X-ray photoelectron spectroscopy (XPS) measurements indicate that the oxygen deficiency strongly affects the energy level of the valence band edge. Correspondingly, the resistance changes of the VO 2 films from 1 to 4.5 orders of magnitude are achieved by LTP. The effect of oxygen vacancy on the electric field driven MIT is investigated. The threshold value of voltage triggering the MIT decreases with increasing the oxygen vacancy concentration. This work demonstrates a novel and effective way to control the content of oxygen vacancies in VO 2 and the obvious impact of oxygen vacancy on MIT, facilitating further research on the role of oxygen vacancy in structure and MIT of VO 2 , which is important for the deep understanding of MIT and exploiting innovative functional application of VO 2 .

Designs of LiMIT as a Limiter in the EAST Tokamak

NASA Astrophysics Data System (ADS)

Szott, Matthew; Christenson, Michael; Kalathiparambil, Kishor; Ruzic, David

2016-10-01

Liquid metal plasma facing components (PFCs) provide a constantly refreshing, self-healing surface that can reduce erosion and thermal stress damage to prolong device lifetime, and additionally decrease edge recycling, reduce impurities, and enhance plasma performance. The Liquid Metal Infused Trench (LiMIT) system, developed at UIUC, has demonstrated thermoelectric magnetohydrodynamic (TEMHD) driven flow of liquid lithium through series of solid trenches. This TEMHD effect drives liquid lithium in fusion systems using the plasma heat flux and the toroidal magnetic field, and the surface tension of the liquid lithium maintains a fresh surface on top of the solid trenches. LiMIT has been successfully tested at UIUC as well as HT-7 and Magnum PSI at heat fluxes up to 3 MW/m2. The next step is demonstrating system viability in full-scale fusion-relevant conditions. In collaboration with a team in Hefei, design and testing has begun for a large scale LiMIT system that will act as a limiter in EAST. The designs improve upon previous versions of LiMIT tested at Illinois and incorporate lessons learned from earlier tests of liquid metal PFCs at EAST. Existing infrastructure is used to load and supply lithium to the system, and the LiMIT trenches will help maintain a smooth, fresh surface as well as aid in propelling the lithium out of direct plasma flux to improve heat transfer. Supported by DOE/ALPS DE-FG02-99ER54515.

Multiple Impulse Therapy in the Assessment of Paraspinal Muscle Tone in Patients with Low Back Pain.

PubMed

Haładaj, Robert; Topol, Mirosław

2016-11-30

Back pain is quite common in contemporary society, whose expectations of an effective analgesic therapy in conservative treatment lead to a necessity of searching for new diagnostic and therapeutic methods in physiotherapy. Out of the numerous physical therapy methods, Multiple Impulse Therapy (MIT) deserves special consideration. This paper aims to present and analyse the outcomes of MIT concerning paraspinal muscle tone and pain intensity in patients with low back pain. The study enrolled 117 patients (50 women and 67 men; average age of 45.3 yrs) with lumbar conditions confirmed by imaging studies. The participants received five MIT sessions within 14 days. Moreover, both before and after the therapy all the patients underwent bilateral assessment of the paraspinal muscle tone by surface electromyography (sEMG) with the NoraxonMyoTrace 400 system and an interactive head of the PulStarFRAS device. A VAS was used for evaluation of pain severity. The analysis of significance of differences between scores before and after treatment showed that all the parameters changed significantly (MIT: 11.11 Ibf before and 8.89 Ibf after the therapy; VAS: 6.04 before and 3.38 afterwards; sEMG: 9.29uV before and 7.51uV afterwards). 1. Multiple Impulse Therapy (MIT) is an effective and non-invasive method of back pain treatment. 2. MIT significantly reduces paraspinal muscle tone, as confirmed by sEMG results, and shows a strong analgesic effect.

Comparative analysis of Mouse Inoculation Test and Virus Isolation in Cell Culture for rabies diagnosis in animals of Parana, Brazil.

PubMed

Corona, Thaila Francini; Böger, Beatriz; Rocha, Tatiana Carneiro da; Svoboda, Walfrido Külh; Gomes, Eliane Carneiro

2018-01-01

Rabies is an acute zoonotic disease, caused by a rhabdovirus that can affect all mammals, and is commonly transmitted by the bite of a rabid animal. The definitive diagnosis is laboratorial, by the Fluorescent Antibody Test (FAT) as a quick test and Mouse Inoculation Test (MIT) as a confirmatory test (gold standard). Studies conducted over the past three decades indicate that MIT and Virus Isolation in Cell Culture (VICC) can provide the same effectiveness, the latter being considered superior in bioethics and animal welfare. The aim of this study was to compare VICC with MIT, in terms of accuracy, biosafety and occupational health, supply and equipment costs, bioethics and animal welfare, in a Brazilian public health lab. We utilized 400 samples of animal neurological tissue to compare the performance of VICC against MIT. The variables analyzed were accuracy, biosafety and occupational health, time spent in performing the tests, supply and equipment costs, bioethics and animal welfare evaluation. Both VICC and MIT had almost the same accuracy (99.8%), although VICC presented fewer risks regarding biosafety and mental health of the technicians, and reduced time between inoculation and obtaining the results (approximately 22 days less). In addition, VICC presented lower supply costs (86.5% less), equipment costs (32.6% less), and the advantage of not using animals. These results confirm that VICC can replace MIT, offering the same accuracy and better features regarding cost, results, biosafety and occupational health, and bioethics and animal welfare.

[Kombinierte Anwendung von Strahlentherapie und adjuvanter Therapie mit einem Mistelextrakt (Viscum album L.) zur Behandlung des oralen malignen Melanoms beim Hund: Eine retrospektive Studie].

PubMed

von Bodungen, Uta; Ruess, Katja; Reif, Marcus; Biegel, Ulrike

2017-01-01

Hintergrund: Orale maligne Melanome (OMM) des Hundes zeichnen sich durch schnelles Wachstum, lokale Invasion und hohe Metastasierungsraten aus. Extrakte auf Basis von Viscum album L. (VAE) werden zunehmend in der Krebstherapie sowohl in der Human- als auch in der Veterinärmedizin eingesetzt. Ziel unserer Studie war es zu untersuchen, inwieweit die adjuvante Therapie mit VAE eine therapeutische Option zur Behandlung von OMM ist. Besonderes Augenmerk galt dabei der Überlebenszeit und möglichen Nebenwirkungen. Tiere und Methoden: 26 Hunde mit OMM, die in einem der größten veterinäronkologischen Zentren der Schweiz allesamt eine Strahlentherapie erhielten (teilweise nach operativer Tumorresektion) wurden in die retrospektive Studie eingeschlossen: 18 Hunde wurden mit VAE behandelt (1 ml VAE (Iscador®) in ansteigenden Konzentrationen von 0,1 bis 20 mg/ml subkutan 3-mal pro Woche (VAE-Gruppe), 8 erhielten keine adjuvante Behandlung (Vergleichsgruppe). Wir verglichen die Größenentwicklung der OMM sowie die Überlebenszeit. Ergebnisse: Patienten mit Bestrahlung und adjuvanter VAE-Therapie zeigten mit 236 Tagen eine signifikant längere mediane Überlebenszeit im Vergleich zu Patienten mit Bestrahlung, aber ohne adjuvante VAE-Therapie (49 Tage; Log-Rank-Test: p = 0,0047). Die VAE-Therapie verlängerte die Überlebenszeit um mehr als zwei Drittel (Hazard Ratio (HR) = 0,30, 95%-Konfidenzintervall (KI) 0,11-0,86; p = 0,024), während ein höheres Tumorstadium gemäß UICC (Union internationale contre le cancer) einen statistischen Trend zur Verdopplung des Sterberisikos zeigte (UICC-Stadium III/IV vs. I/II: HR = 2,12, 95%-KI 0,88-5,12; p = 0,095). Zwei Patienten zeigten milde Nebenwirkungen während der VAE-Behandlung. Einer der beiden zeigte 1 Tag lang ein selbstlimitiertes Fieber, bei dem anderen Patienten reduzierten wir die Dosis von einem konzentrierteren zu einem weniger konzentrierten VAE (Serie 0) aufgrund von Müdigkeit, die daraufhin verschwand. Schlussfolgerungen: VAE ist eine sichere, nebenwirkungsarme Behandlung und scheint sich positiv auf die Überlebenszeit von Hunden mit OMM auszuwirken. Somit ist dieser therapeutische Ansatz es wert, vermehrt bei der adjuvant zur Strahlentherapie eingesetzten Behandlung des OMM in Betracht gezogen zu werden. Die verglichenen Gruppen waren jedoch klein, divers und nicht konsistent hinsichtlich aller prognostischen Parameter. Eine prospektive Studie mit einer größeren Studienpopulation wäre daher von Interesse. © 2017 S. Karger GmbH, Freiburg.

NASA’s Stennis Space Center Conducts RS-25 Engine Test

NASA Image and Video Library

2017-03-24

On March 23, NASA conducted a test of an RS-25 engine at the agency’s Stennis Space Center in Bay St. Louis, Mississippi. Four RS-25’s will help power NASA’s Space Launch System (SLS) rocket to space. During this test, engineers evaluated the engine’s new controller or “brain”, which communicates with the SLS vehicle. Once test data is certified, the engine controller will be removed and installed on one of the four flight engines that will help power the first integrated flight of SLS and the Orion spacecraft.

Space Shuttle Main Engine Public Test Firing

NASA Image and Video Library

2000-07-25

A new NASA Space Shuttle Main Engine (SSME) roars to the approval of more than 2,000 people who came to John C. Stennis Space Center in Hancock County, Miss., on July 25 for a flight-certification test of the SSME Block II configuration. The engine, a new and significantly upgraded shuttle engine, was delivered to NASA's Kennedy Space Center in Florida for use on future shuttle missions. Spectators were able to experience the 'shake, rattle and roar' of the engine, which ran for 520 seconds - the length of time it takes a shuttle to reach orbit.

14 CFR 63.42 - Flight engineer certificate issued on basis of a foreign flight engineer license.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Flight engineer certificate issued on basis of a foreign flight engineer license. 63.42 Section 63.42 Aeronautics and Space FEDERAL AVIATION... PILOTS Flight Engineers § 63.42 Flight engineer certificate issued on basis of a foreign flight engineer...

14 CFR 63.42 - Flight engineer certificate issued on basis of a foreign flight engineer license.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Flight engineer certificate issued on basis of a foreign flight engineer license. 63.42 Section 63.42 Aeronautics and Space FEDERAL AVIATION... PILOTS Flight Engineers § 63.42 Flight engineer certificate issued on basis of a foreign flight engineer...