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Sample records for mller lene andersen

  1. 40 CFR 721.3560 - Derivative of tetra-chloro-ethy-lene.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Derivative of tetra-chloro-ethy-lene... Substances § 721.3560 Derivative of tetra-chloro-ethy-lene. (a) Chemical substance and significant new uses... described in paragraph (a)(2) of this section: Derivative of tetrachloroethylene, P-82-684. (2) The...

  2. Matthew Andersen d/b/a Andersen Painting Information Sheet

    EPA Pesticide Factsheets

    Matthew Andersen d/b/a Andersen Painting (the Company) is located in Omaha, Nebraska. The settlement involves renovation activities conducted on a property constructed prior to 1978, located in Bellevue, Nebraska.

  3. Qualitative issues in the evolution of the Andersen Lighthouse

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    De Keyser, D.; Gratz, S.; Barton, S.A.

    1995-11-01

    This paper reports on the continuing product development of the Andersen Lighthouse. Refer to ``Development of the Andersen Lighthouse for the Wal-Mart Environmental Demonstration Store`` in the Solar `94 Conference Proceedings for a description of the Andersen Lighthouse. The goals for this project were to evaluate the following qualitative issues surrounding daylighting: color rendition, quality of light, view to the sky, and human perception. In order to evaluate the effects of the Andersen Lighthouse the authors compared it to a high transmission translucent (acrylic bubble) skylight and an ordinary translucent (acrylic bubble) skylight. In addition to the above comparison, amore » test installation of Andersen Lighthouses in a manufacturing space was analyzed. This case study covers the affect the introduction of natural light and view had on the comfort and productivity of the employees. Visual observations, illumination readings, and employee questionnaires were used for evaluation.« less

  4. 40 CFR 721.5960 - N,N′-Bis(2-(2-(3-alkyl)thia- zoline) vinyl)-1,4-pheny-lene-dia-mine methyl sulfate double salt...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) vinyl)-1,4-pheny-lene-dia-mine methyl sulfate double salt (generic name). 721.5960 Section 721.5960...,N′-Bis(2-(2-(3-alkyl)thia- zoline) vinyl)-1,4-pheny-lene-dia-mine methyl sulfate double salt... methyl sulfate double salt (PMN P-84-913) is subject to reporting under this section for the significant...

  5. 40 CFR 721.5960 - N,N′-Bis(2-(2-(3-alkyl)thia- zoline) vinyl)-1,4-pheny-lene-dia-mine methyl sulfate double salt...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) vinyl)-1,4-pheny-lene-dia-mine methyl sulfate double salt (generic name). 721.5960 Section 721.5960...,N′-Bis(2-(2-(3-alkyl)thia- zoline) vinyl)-1,4-pheny-lene-dia-mine methyl sulfate double salt... methyl sulfate double salt (PMN P-84-913) is subject to reporting under this section for the significant...

  6. 40 CFR 721.5960 - N,N′-Bis(2-(2-(3-alkyl)thia- zoline) vinyl)-1,4-pheny-lene-dia-mine methyl sulfate double salt...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) vinyl)-1,4-pheny-lene-dia-mine methyl sulfate double salt (generic name). 721.5960 Section 721.5960...,N′-Bis(2-(2-(3-alkyl)thia- zoline) vinyl)-1,4-pheny-lene-dia-mine methyl sulfate double salt... methyl sulfate double salt (PMN P-84-913) is subject to reporting under this section for the significant...

  7. Finite-density effects in the Fredrickson-Andersen and Kob-Andersen kinetically-constrained models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Teomy, Eial, E-mail: eialteom@post.tau.ac.il; Shokef, Yair, E-mail: shokef@tau.ac.il

    2014-08-14

    We calculate the corrections to the thermodynamic limit of the critical density for jamming in the Kob-Andersen and Fredrickson-Andersen kinetically-constrained models, and find them to be finite-density corrections, and not finite-size corrections. We do this by introducing a new numerical algorithm, which requires negligible computer memory since contrary to alternative approaches, it generates at each point only the necessary data. The algorithm starts from a single unfrozen site and at each step randomly generates the neighbors of the unfrozen region and checks whether they are frozen or not. Our results correspond to systems of size greater than 10{sup 7} ×more » 10{sup 7}, much larger than any simulated before, and are consistent with the rigorous bounds on the asymptotic corrections. We also find that the average number of sites that seed a critical droplet is greater than 1.« less

  8. Genetics Home Reference: Andersen-Tawil syndrome

    MedlinePlus

    ... medical literature. Researchers believe that Andersen-Tawil syndrome accounts for less than 10 percent of all cases of periodic paralysis. Related Information What information about a genetic condition can statistics ...

  9. In vivo and in vitro functional characterization of Andersen's syndrome mutations.

    PubMed

    Bendahhou, Saïd; Fournier, Emmanuel; Sternberg, Damien; Bassez, Guillaume; Furby, Alain; Sereni, Carole; Donaldson, Matthew R; Larroque, Marie-Madeleine; Fontaine, Bertrand; Barhanin, Jacques

    2005-06-15

    The inward rectifier K(+) channel Kir2.1 carries all Andersen's syndrome mutations identified to date. Patients exhibit symptoms of periodic paralysis, cardiac dysrhythmia and multiple dysmorphic features. Here, we report the clinical manifestations found in three families with Andersen's syndrome. Molecular genetics analysis identified two novel missense mutations in the KCNJ2 gene leading to amino acid changes C154F and T309I of the Kir2.1 open reading frame. Patch clamp experiments showed that the two mutations produced a loss of channel function. When co-expressed with Kir2.1 wild-type (WT) channels, both mutations exerted a dominant-negative effect leading to a loss of the inward rectifying K(+) current. Confocal microscopy imaging in HEK293 cells is consistent with a co-assembly of the EGFP-fused mutant proteins with WT channels and proper traffick to the plasma membrane to produce silent channels alone or as hetero-tetramers with WT. Functional expression in C2C12 muscle cell line of newly as well as previously reported Andersen's syndrome mutations confirmed that these mutations act through a dominant-negative effect by altering channel gating or trafficking. Finally, in vivo electromyographic evaluation showed a decrease in muscle excitability in Andersen's syndrome patients. We hypothesize that Andersen's syndrome-associated mutations and hypokalaemic periodic paralysis-associated calcium channel mutations may lead to muscle membrane hypoexcitability via a common mechanism.

  10. In vivo and in vitro functional characterization of Andersen's syndrome mutations

    PubMed Central

    Bendahhou, Saïd; Fournier, Emmanuel; Sternberg, Damien; Bassez, Guillaume; Furby, Alain; Sereni, Carole; Donaldson, Matthew R; Larroque, Marie-Madeleine; Fontaine, Bertrand; Barhanin, Jacques

    2005-01-01

    The inward rectifier K+ channel Kir2.1 carries all Andersen's syndrome mutations identified to date. Patients exhibit symptoms of periodic paralysis, cardiac dysrhythmia and multiple dysmorphic features. Here, we report the clinical manifestations found in three families with Andersen's syndrome. Molecular genetics analysis identified two novel missense mutations in the KCNJ2 gene leading to amino acid changes C154F and T309I of the Kir2.1 open reading frame. Patch clamp experiments showed that the two mutations produced a loss of channel function. When co-expressed with Kir2.1 wild-type (WT) channels, both mutations exerted a dominant-negative effect leading to a loss of the inward rectifying K+ current. Confocal microscopy imaging in HEK293 cells is consistent with a co-assembly of the EGFP-fused mutant proteins with WT channels and proper traffick to the plasma membrane to produce silent channels alone or as hetero-tetramers with WT. Functional expression in C2C12 muscle cell line of newly as well as previously reported Andersen's syndrome mutations confirmed that these mutations act through a dominant-negative effect by altering channel gating or trafficking. Finally, in vivo electromyographic evaluation showed a decrease in muscle excitability in Andersen's syndrome patients. We hypothesize that Andersen's syndrome-associated mutations and hypokalaemic periodic paralysis-associated calcium channel mutations may lead to muscle membrane hypoexcitability via a common mechanism. PMID:15831539

  11. Loyal clients. Despite Arthur Andersen's indictment, healthcare companies aren't defecting.

    PubMed

    Jaklevic, Mary Chris

    2002-03-25

    In contrast to about 50 defections by public companies, many healthcare clients of Andersen are standing by the troubled auditor--at least for now. Saying that it's too soon to judge, clients such as the Catholic Health Association are sitting tight to see what the fallout is from the Enron scandal before making any decisions. And even if many part ways with Andersen, there's a host of consultants to take its place.

  12. Issuing and Responding to Unusual Questions: A Conversation Analytic Account of Tom Andersen's Therapeutic Practice.

    PubMed

    Smoliak, Olga; Le Couteur, Amanda; Quinn-Nilas, Christopher

    2018-03-08

    Tom Andersen is considered one of the key contributors to the development of postmodern practice. Little is known, however, about the ways in which his ideas and practices are routinely carried out in situ. We used Conversation Analysis (CA) to investigate a session of couple therapy facilitated by Andersen. We show how Andersen and client participants oriented to and addressed problems of understanding that occurred between them. The source of this trouble was Andersen's use of unusual question formulations. We offer preliminary evidence that such unusual formulations served particular interactional and institutional (i.e., therapeutic) functions in their local contexts of use. We conclude by considering some implications of this analysis-and of conversation analytic inquiry more generally-for the practice of family therapy. © 2018 American Association for Marriage and Family Therapy.

  13. Notes on Barkas-Andersen effect

    NASA Astrophysics Data System (ADS)

    Sigmund, Peter; Schinner, Andreas

    2014-10-01

    Stimulated by recent statements in the literature on electronic stopping of heavy ions in matter, we try to clarify some central theoretical aspects of the Barkas-Andersen effect, about which there does not seem to be unanimous agreement in the community. We address the role of inner versus outer target shells, of projectile screening by bound electrons, the interference between Lindhard's description and perturbation theory, as well as the equivalence between a single-electron versus Fermi-gas description of the effect.

  14. High Tech Training at Arthur Andersen and Co.

    ERIC Educational Resources Information Center

    Dennis, Verl E.

    1984-01-01

    Discusses Arthur Andersen and Company's reasons for using high technology in job training, including its ability to improve productivity, provide training on demand, reduce training costs, and keep educational quality consistent. A Life Cycle Model which is used to integrate high technology into this accounting company's educational programs is…

  15. The legacy of Tom Andersen: The ethics of reflecting processes.

    PubMed

    Gehart, Diane R

    2018-03-08

    Tom Andersen and his pioneering work with reflecting conservations has had a lasting influence on the field of family therapy and mental health more broadly. Most family therapists are familiar with his contributions related to reflecting teams; however, fewer are familiar with his conceptualization of reflecting processes, which offer practical ways to approach therapeutic conversations to address challenging problems. This article provides a brief history of Andersen's career and reviews four key elements of his approach, including: (a) his way of being in relationship, (b) appropriately unusual comments, (c) inner and outer dialogs, and (d) ethics of dialogical relating. Finally, this article introduces readers to the context of the video that will be analyzed in the articles that follow in this special section. © 2018 American Association for Marriage and Family Therapy.

  16. Redemptive Journey: The Storytelling Motif in Andersen's "The Snow Queen."

    ERIC Educational Resources Information Center

    Misheff, Sue

    1989-01-01

    Discusses how Hans Christian Andersen's "The Snow Queen" uses the motif of storytelling to describe the journey taken by the heroine Gerda. Identifies a story as that which is alive and active and which causes catharsis for those who participate in it. (MG)

  17. Computer Managed Instruction at Arthur Andersen & Company: A Status Report.

    ERIC Educational Resources Information Center

    Dennis, Verl E.; Gruner, Dennis

    1992-01-01

    Computer managed instruction (CMI) based on the principle of mastery learning has been cost effective for job training in the tax division of Arthur Andersen & Company. The CMI software system, which uses computerized pretests and posttests to monitor training, has been upgraded from microcomputer use to local area networks. Success factors at…

  18. Electrochemical Advanced Oxidation Process for Shipboard Final Purification of Filtered Black Water, Gray Water, and Bilge Water, Vol. 1

    DTIC Science & Technology

    2001-08-01

    doped SnO2 developed by Memming and M`llers (1972) is most directly applicable to our electrodes. This model ignores the effect of ions in the...electron transfer model of Memming and M`llers (1972) with the surface charging/ ion complexation model of Davis et al. (1978). The combined model...model of Memming and M`llers. The model of Davis et al. represents the diffuse double layer by an analytical expression which describes only pure

  19. The Andersen aerobic fitness test: New peak oxygen consumption prediction equations in 10 and 16-year olds.

    PubMed

    Aadland, E; Andersen, L B; Lerum, Ø; Resaland, G K

    2018-03-01

    Measurement of aerobic fitness by determining peak oxygen consumption (VO 2peak ) is often not feasible in children and adolescents, thus field tests such as the Andersen test are required in many settings, for example in most school-based studies. This study provides cross-validated prediction equations for VO 2peak based on the Andersen test in 10 and 16-year-old children. We included 235 children (n = 113 10-year olds and 122 16-year olds) who performed the Andersen test and a progressive treadmill test to exhaustion to determine VO 2peak . Joint and sex-specific prediction equations were derived and tested in 20 random samples. Performance in terms of systematic (bias) and random error (limits of agreement) was evaluated by means of Bland-Altman plots. Bias varied from -4.28 to 5.25 mL/kg/min across testing datasets, sex, and the 2 age groups. Sex-specific equations (mean bias -0.42 to 0.16 mL/kg/min) performed somewhat better than joint equations (-1.07 to 0.84 mL/kg/min). Limits of agreement were substantial across all datasets, sex, and both age groups, but were slightly lower in 16-year olds (5.84-13.29 mL/kg/min) compared to 10-year olds (9.60-15.15 mL/kg/min). We suggest the presented equations can be used to predict VO 2peak from the Andersen test performance in children and adolescents on a group level. Although the Andersen test appears to be a good measure of aerobic fitness, researchers should interpret cross-sectional individual-level predictions of VO 2peak with caution due to large random measurement errors. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. Health care costs in the elderly in Germany: an analysis applying Andersen's behavioral model of health care utilization.

    PubMed

    Heider, Dirk; Matschinger, Herbert; Müller, Heiko; Saum, Kai-Uwe; Quinzler, Renate; Haefeli, Walter Emil; Wild, Beate; Lehnert, Thomas; Brenner, Hermann; König, Hans-Helmut

    2014-02-14

    To analyze the association of health care costs with predisposing, enabling, and need factors, as defined by Andersen's behavioral model of health care utilization, in the German elderly population. Using a cross-sectional design, cost data of 3,124 participants aged 57-84 years in the 8-year-follow-up of the ESTHER cohort study were analyzed. Health care utilization in a 3-month period was assessed retrospectively through an interview conducted by trained study physicians at respondents' homes. Unit costs were applied to calculate health care costs from the societal perspective. Socio-demographic and health-related variables were categorized as predisposing, enabling, or need factors as defined by the Andersen model. Multimorbidity was measured by the Cumulative Illness Rating Scale for Geriatrics (CIRS-G). Mental health status was measured by the SF-12 mental component summary (MCS) score. Sector-specific costs were analyzed by means of multiple Tobit regression models. Mean total costs per respondent were 889 € for the 3-month period. The CIRS-G score and the SF-12 MCS score representing the need factor in the Andersen model were consistently associated with total, inpatient, outpatient and nursing costs. Among the predisposing factors, age was positively associated with outpatient costs, nursing costs, and total costs, and the BMI was associated with outpatient costs. Multimorbidity and mental health status, both reflecting the need factor in the Andersen model, were the dominant predictors of health care costs. Predisposing and enabling factors had comparatively little impact on health care costs, possibly due to the characteristics of the German social health insurance system. Overall, the variables used in the Andersen model explained only little of the total variance in health care costs.

  1. Aerobic fitness testing in 6- to 9-year-old children: reliability and validity of a modified Yo-Yo IR1 test and the Andersen test.

    PubMed

    Ahler, T; Bendiksen, M; Krustrup, P; Wedderkopp, N

    2012-03-01

    This study analysed the reliability and validity of two intermittent running tests (the Yo-Yo IR1 test and the Andersen test) as tools for estimating VO(2max) in children under the age of 10. Two groups, aged 6-7 years (grade 0, n = 18) and 8-9 years (grade 2, n = 16), carried out two repetitions of a modified Yo-Yo IR1 test (2 × 16 m) and the Andersen test, as well as an incremental treadmill test, to directly determine the VO(2max). No significant differences were observed in test-retest performance of the Yo-Yo IR1 test [693 ± 418 (±SD) and 670 ± 328 m, r (2) = 0.79, CV = 19%, p > 0.05, n = 32) and the Andersen test (988 ± 77 and 989 ± 87 m, r (2) = 0.86, CV = 3%, p > 0.05, n = 31). The Yo-Yo IR1 (r (2) = 0.47, n = 31, p < 0.002) and Andersen test performance (r (2) = 0.53, n = 32, p < 0.001) correlated with the VO(2max). Yo-Yo IR1 performance correlated with Andersen test performance (r (2) = 0.74, n = 32, p < 0.0001). In conclusion, the Yo-Yo IR1 and the Andersen tests are reproducible and can be used as an indicator of aerobic fitness for 6- to 9-year-old children.

  2. Calibration of a Modified Andersen Bacterial Aerosol Sampler

    PubMed Central

    May, K. R.

    1964-01-01

    A study of the flow regime in the commercial Andersen sampler revealed defects in the sampling of the larger airborne particles. Satisfactory sampling was obtained by redesigning the hole pattern of the top stages and adding one more stage to extend the range of the instrument. A new, rational hole pattern is suggested for the lower stages. With both patterns a special colony-counting mask can be used to facilitate the assay. A calibration of the modified system is presented which enables particle size distribution curves to be drawn from the colony counts. Images FIG. 2 FIG. 3 FIG. 4 FIG. 5 FIG. 6 FIG. 7 FIG. 8 PMID:14106938

  3. Help-Seeking Behavior Following a Community Tragedy: An Application of the Andersen Model

    ERIC Educational Resources Information Center

    Cowart, Brian L.

    2013-01-01

    For healthcare agencies and other professionals to most efficiently provide aid following large scale community tragedies, agencies and professionals must understand the determinants that lead individuals to require and seek various forms of help. This study examined Andersen's Behavioral Model of Healthcare Use and its utility in predicting…

  4. Constructing Unfinalizability: A Subject Positioning Analysis of a Couple's Therapy Session Hosted by Tom Andersen.

    PubMed

    Guilfoyle, Michael

    2018-03-08

    The notion of subject positions is a useful tool in thinking through therapeutic interactions. In this article, I discuss positioning as an everyday phenomenon, and highlight the relational and social power dynamics that shape the subject positions persons may inhabit. Analysis is presented of the positional dynamics that play out in the couple's therapy session facilitated by Tom Andersen. Analysis suggests that Andersen adopts a not-knowing, uncertain, and curious position, while constructing the couple as competent, unfinalizable persons able to negotiate the choice-points that arise in front of them. However, if subject positions are grounded in social power dynamics, the session leaves a particular question unanswered: How will these emergent positions take hold outside of the consulting room? © 2018 American Association for Marriage and Family Therapy.

  5. On a perturbed Sparre Andersen risk model with multi-layer dividend strategy

    NASA Astrophysics Data System (ADS)

    Yang, Hu; Zhang, Zhimin

    2009-10-01

    In this paper, we consider a perturbed Sparre Andersen risk model, in which the inter-claim times are generalized Erlang(n) distributed. Under the multi-layer dividend strategy, piece-wise integro-differential equations for the discounted penalty functions are derived, and a recursive approach is applied to express the solutions. A numerical example to calculate the ruin probabilities is given to illustrate the solution procedure.

  6. The perturbed Sparre Andersen model with a threshold dividend strategy

    NASA Astrophysics Data System (ADS)

    Gao, Heli; Yin, Chuancun

    2008-10-01

    In this paper, we consider a Sparre Andersen model perturbed by diffusion with generalized Erlang(n)-distributed inter-claim times and a threshold dividend strategy. Integro-differential equations with certain boundary conditions for the moment-generation function and the mth moment of the present value of all dividends until ruin are derived. We also derive integro-differential equations with boundary conditions for the Gerber-Shiu functions. The special case where the inter-claim times are Erlang(2) distributed and the claim size distribution is exponential is considered in some details.

  7. A multispin algorithm for the Kob-Andersen stochastic dynamics on regular lattices

    NASA Astrophysics Data System (ADS)

    Boccagna, Roberto

    2017-07-01

    The aim of the paper is to propose an algorithm based on the Multispin Coding technique for the Kob-Andersen glassy dynamics. We first give motivations to speed up the numerical simulation in the context of spin glass models [M. Mezard, G. Parisi, M. Virasoro, Spin Glass Theory and Beyond (World Scientific, Singapore, 1987)]; after defining the Markovian dynamics as in [W. Kob, H.C. Andersen, Phys. Rev. E 48, 4364 (1993)] as well as the related interesting observables, we extend it to the more general framework of random regular graphs, listing at the same time some known analytical results [C. Toninelli, G. Biroli, D.S. Fisher, J. Stat. Phys. 120, 167 (2005)]. The purpose of this work is a dual one; firstly, we describe how bitwise operators can be used to build up the algorithm by carefully exploiting the way data are stored on a computer. Since it was first introduced [M. Creutz, L. Jacobs, C. Rebbi, Phys. Rev. D 20, 1915 (1979); C. Rebbi, R.H. Swendsen, Phys. Rev. D 21, 4094 (1980)], this technique has been widely used to perform Monte Carlo simulations for Ising and Potts spin systems; however, it can be successfully adapted to more complex systems in which microscopic parameters may assume boolean values. Secondly, we introduce a random graph in which a characteristic parameter allows to tune the possible transition point. A consistent part is devoted to listing the numerical results obtained by running numerical simulations.

  8. Thermal response of a Fermi-Pasta-Ulam chain with Andersen thermostats

    NASA Astrophysics Data System (ADS)

    D'Ambrosio, Federico; Baiesi, Marco

    2017-11-01

    The linear response to temperature variations is well characterised for equilibrium systems but a similar theory is not available, for example, for inertial heat conducting systems, whose paradigm is the Fermi-Pasta-Ulam (FPU) model driven by two different boundary temperatures. For models of inertial systems out of equilibrium, including relaxing systems, we show that Andersen thermostats are a natural tool for studying the thermal response. We derive a fluctuation-response relation that allows to predict thermal expansion coefficients or the heat capacitance in nonequilibrium regimes. Simulations of the FPU chain of oscillators suggest that estimates of susceptibilities obtained with our relation are better than those obtained via a small perturbation.

  9. Contextual and individual determinants of periodontal disease: Multilevel analysis based on Andersen's model.

    PubMed

    Valente, Maria I B; Vettore, Mario V

    2018-04-01

    To investigate the relationship of contextual and individual factors with periodontal disease in dentate adults and older people using the Andersen's behavioural model. Secondary individual data from 6011 adults and 2369 older people from the Brazilian Oral Health Survey (2010) were combined with contextual data for 27 cities. Attachment loss (AL) categories for each sextant were coded and summed to obtain the periodontal disease measure. The association of predisposing, enabling and need characteristics at city and individual level with periodontal disease was assessed using an adapted version of the Andersen's behavioural model. Multilevel Poisson regression was used to estimate rate ratios (RR) and 95% CIs. Periodontal disease was associated with contextual predisposing (RR 0.93; 95% CI = 0.87-0.99) and enabling factors (RR 0.99; 95% CI = 0.98-0.99) in adults. Contextual predisposing was also associated with periodontal disease in older people (RR 0.82; 95% CI = 0.73-0.92). Individual predisposing (age, sex and schooling) and need characteristics (perceived treatment need) were common predictors of periodontal disease in adults and older people. Periodontal disease was also associated with behaviours in the latter age group. Contextual predisposing factors and individual characteristics influenced periodontal disease experience in adults and older people. Contextual enabling factors were also meaningful determinants of periodontal disease in the former age group. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Expanding the Andersen Model: The Role of Psychosocial Factors in Long-Term Care Use

    PubMed Central

    Bradley, Elizabeth H; McGraw, Sarah A; Curry, Leslie; Buckser, Alison; King, Kinda L; Kasl, Stanislav V; Andersen, Ronald

    2002-01-01

    Objective To examine a prevailing conceptual model of health services use (Andersen 1995) and to suggest modifications that may enhance its explanatory power when applied to empirical studies of race/ethnicity and long-term care. Study Setting Twelve focus groups of African-American (five groups) and white (seven groups) individuals, aged 65 and older, residing in Connecticut during 2000. Study Design Using qualitative analysis, data were coded and analyzed in NUD-IST 4 software to facilitate the reporting of recurrent themes, supporting quotations, and links among the themes for developing the conceptual framework. Specific analysis was conducted to assess distinctions in common themes between African-American and white focus groups. Data Collection Data were collected using a standardized discussion guide, augmented by prompts for clarification. Audio taped sessions were transcribed and independently coded by investigators and crosschecked to enhance coding validity. An audit trail was maintained to document analytic decisions during data analysis and interpretation. Principal Findings Psychosocial factors (e.g., attitudes and knowledge, social norms, and perceived control) are identified as determinants of service use, thereby expanding the Andersen model (1995). African-American and white focus group members differed in their reported accessibility of information about long-term care, social norms concerning caregiving expectations and burden, and concerns of privacy and self-determination. Conclusions More comprehensive identification of psychosocial factors may enhance our understanding of the complex role of race/ethnicity in long-term care use as well as the effectiveness of policies and programs designed to address disparities in long-term care service use among minority and nonminority groups. PMID:12479494

  11. Expanding the Andersen model: the role of psychosocial factors in long-term care use.

    PubMed

    Bradley, Elizabeth H; McGraw, Sarah A; Curry, Leslie; Buckser, Alison; King, Kinda L; Kasl, Stanislav V; Andersen, Ronald

    2002-10-01

    To examine a prevailing conceptual model of health services use (Andersen 1995) and to suggest modifications that may enhance its explanatory power when applied to empirical studies of race/ethnicity and long-term care. Twelve focus groups of African-American (five groups) and white (seven groups) individuals, aged 65 and older, residing in Connecticut during 2000. Using qualitative analysis, data were coded and analyzed in NUD-IST 4 software to facilitate the reporting of recurrent themes, supporting quotations, and links among the themes for developing the conceptual framework. Specific analysis was conducted to assess distinctions in common themes between African-American and white focus groups. Data were collected using a standardized discussion guide, augmented by prompts for clarification. Audio taped sessions were transcribed and independently coded by investigators and crosschecked to enhance coding validity. An audit trail was maintained to document analytic decisions during data analysis and interpretation. Psychosocial factors (e.g., attitudes and knowledge, social norms, and perceived control) are identified as determinants of service use, thereby expanding the Andersen model (1995). African-American and white focus group members differed in their reported accessibility of information about long-term care, social norms concerning caregiving expectations and burden, and concerns of privacy and self-determination. More comprehensive identification of psychosocial factors may enhance our understanding of the complex role of race/ethnicity in long-term care use as well as the effectiveness of policies and programs designed to address disparities in long-term care service use among minority and nonminority groups.

  12. Membrane dysfunction in Andersen-Tawil syndrome assessed by velocity recovery cycles.

    PubMed

    Tan, S Veronica; Z'graggen, Werner J; Boërio, Delphine; Rayan, Dipa L Raja; Howard, Robin; Hanna, Michael G; Bostock, Hugh

    2012-08-01

    Andersen-Tawil syndrome (ATS) due to Kir2.1mutations typically manifests as periodic paralysis, cardiac arrhythmias and developmental abnormalities but is often difficult to diagnose clinically. This study was undertaken to determine whether sarcolemmal dysfunction could be identified with muscle velocity recovery cycles (MVRCs). Eleven genetically confirmed ATS patients and 20 normal controls were studied. MVRCs were recorded with 1, 2, and 5 conditioning stimuli and with single conditioning stimuli during intermittent repetitive stimulation at 20 Hz, in addition to the long exercise test. ATS patients had longer relative refractory periods (P < 0.0001) and less early supernormality, consistent with membrane depolarization. Patients had reduced enhancement of late supernormality with 5 conditioning stimuli (P < 0.0001), and less latency reduction during repetitive stimulation (P < 0.001). Patients were separated completely from controls by combining MVRC and repetitive stimulation. MVRCs combined with repetitive stimulation differentiated ATS patients from controls more effectively than the conventional long-exercise test. Copyright © 2012 Wiley Periodicals, Inc.

  13. Self-care behaviour for minor symptoms: can Andersen's Behavioral Model of Health Services Use help us to understand it?

    PubMed

    Porteous, Terry; Wyke, Sally; Hannaford, Philip; Bond, Christine

    2015-02-01

    To explore whether Andersen's Behavioral Model of Health Services Use can aid understanding of self-care behaviour and inform development of interventions to promote self-care for minor illness. Qualitative interviews were conducted with 24 Scottish participants about their experience and management of minor symptoms normally associated with analgesic use. Synthesised data from the interviews were mapped onto the Behavioral Model. All factors identified as influencing decisions about how to manage the symptoms discussed, mapped onto at least one domain of Andersen's model. Individual characteristics including beliefs, need factors and available resources were associated with health behaviour, including self-care. Outcomes such as perceived health status and consumer satisfaction from previous experience of managing symptoms also appeared to feed back into health behaviour. The Behavioral Model seems relevant to self-care as well as formal health services. Additional work is needed to explore applicability of the Behavioral Model to different types of symptoms, different modalities of self-care and in countries with different health care systems. Future quantitative studies should establish the relative importance of factors influencing the actions people take to manage minor symptoms to inform future interventions aimed at optimising self-care behaviour. © 2014 Royal Pharmaceutical Society.

  14. Severe exacerbation of Andersen-Tawil syndrome secondary to thyrotoxicosis.

    PubMed

    Díaz-Manera, Jordi; Querol, Luis; Alejaldre, Aída; Rojas-García, Ricard; Ramos-Fransi, Alba; Gallardo, Eduard; Illa, Isabel

    2014-08-01

    Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism characterized by episodes of weakness. Although TPP has been described in patients all over the world, it is especially frequent in Asiatic patients. Recently, two genomewide association studies have found a susceptibility locus on chromosome 17q24.3 near the KCNJ2 gene, which is responsible for another cause of periodic paralysis, the Andersen-Tawil syndrome (ATS). We report the first patient diagnosed with ATS with a de novo c.G899C mutation in the KCNJ2 gene in 2010 who developed an autoimmune hyperthyroidism and TPP in 2013. At the time of the ATS diagnosis other causes of periodic paralysis, including thyroid dysfunction, were ruled out. The condition of the patient, who had mild episodes of proximal weakness at follow-up, deteriorated dramatically in 2013, presenting continuous episodes of severe generalized weakness associated with low levels of potassium requiring frequent admissions to the hospital. After a few months, he also presented signs of hyperthyroidism, and a diagnosis of Grave's disease was made. In our opinion, this case clearly demonstrates that a dysfunction of the Kir2.1 potassium channel encoded by the KCNJ2 gene is a risk factor to develop TPP, and can be a useful tool to identify patients at risk in daily clinics.

  15. Phase Diagram of Kob-Andersen-Type Binary Lennard-Jones Mixtures

    NASA Astrophysics Data System (ADS)

    Pedersen, Ulf R.; Schrøder, Thomas B.; Dyre, Jeppe C.

    2018-04-01

    The binary Kob-Andersen (KA) Lennard-Jones mixture is the standard model for computational studies of viscous liquids and the glass transition. For very long simulations, the viscous KA system crystallizes, however, by phase separating into a pure A particle phase forming a fcc crystal. We present the thermodynamic phase diagram for KA-type mixtures consisting of up to 50% small (B ) particles showing, in particular, that the melting temperature of the standard KA system at liquid density 1.2 is 1.028(3) in A particle Lennard-Jones units. At large B particle concentrations, the system crystallizes into the CsCl crystal structure. The eutectic corresponding to the fcc and CsCl structures is cutoff in a narrow interval of B particle concentrations around 26% at which the bipyramidal orthorhombic PuBr3 structure is the thermodynamically stable phase. The melting temperature's variation with B particle concentration at two constant pressures, as well as at the constant density 1.2, is estimated from simulations at pressure 10.19 using isomorph theory. Our data demonstrate approximate identity between the melting temperature and the onset temperature below which viscous dynamics appears. Finally, the nature of the solid-liquid interface is briefly discussed.

  16. Corticosteroid-exacerbated symptoms in an Andersen's syndrome kindred.

    PubMed

    Bendahhou, Saïd; Fournier, Emmanuel; Gallet, Serge; Ménard, Dominique; Larroque, Marie-Madeleine; Barhanin, Jacques

    2007-04-15

    Periodic paralysis, cardiac arrhythmia and bone features are the hallmark of Andersen's syndrome (AS), a rare disorder caused by mutations in the KCNJ2 gene that encodes for the inward rectifier K(+)-channel Kir2.1. Rest following strenuous physical activity, carbohydrate ingestion, emotional stress and exposure to cold are the precipitating triggers. Most of the mutations act in a dominant-negative fashion, either through a trafficking dysfunction or through Kir2.1-phosphatidyl inositol bisphosphate binding defect. We have identified two families that were diagnosed with periodic paralysis and cardiac abnormalities, but only discrete development features. The proband in one of the two families reported having his symptoms occurring twice within the day following corticosteroids ingestion, and alleviated after stopping the corticosteroid treatment. Electromyographic evaluations pointed out to a typical hypokalemic periodic paralysis pattern. Molecular screening of the KCNJ2 gene identified two mutations leading to C54F and T305P substitutions in the Kir2.1 protein. Functional expression in mammalian cells revealed a loss-of-function of the mutated channels and a dominant-negative effect when both mutants and wild-type channels are present in the same cell. However, channel trafficking and assembly are not affected. Substitutions at these residues may interfere with phosphatidyl inositol bisphosphate binding to Kir2.1 channels. Sensitivity of our patients to multiple corticosteroid administrations shows that care must be taken in the use of such treatments in AS patients. Taken together, our data suggest the inclusion of the KCNJ2 gene in the molecular screening of patients with periodic paralysis, even when the classical AS dysmorphic features are not present.

  17. "The Other"--A Threat or a Resource? Polar Interpretations of Two Children's Stories: "The Ugly Duckling" by H. C. Andersen and "Raspberry Juice" by H. Shenhav

    ERIC Educational Resources Information Center

    Israeli, Liora

    2011-01-01

    This article examines the educational work towards tolerance by analyzing two opposed social views in children's stories: "The ugly duckling" by H.C. Andersen and "Raspberry Juice" by H. Shenav. "The ugly duckling" depicts a social state based on the evolutional ladder, where the white entity is at the top, and the black one is at the bottom,…

  18. The nature of geometric frustration in the Kob-Andersen mixture

    NASA Astrophysics Data System (ADS)

    Crowther, Peter; Turci, Francesco; Royall, C. Patrick

    2015-07-01

    Geometric frustration is an approach to the glass transition based upon the consideration of locally favoured structures (LFS), which are geometric motifs which minimise the local free energy. Geometric frustration proposes that a transition to a crystalline state is frustrated because these LFS do not tile space. However, this concept is based on icosahedra which are not always the LFS for a given system. The LFS of the popular Kob-Andersen (KA) model glassformer are the bicapped square antiprism, which does tile space. Such a LFS-crystal is indeed realised in the Al2Cu structure, which is predicted to be a low energy state for the KA model with a 2:1 composition. We, therefore, hypothesise that upon changing the composition in the KA model towards 2:1, geometric frustration may be progressively relieved, leading to larger and larger domains of LFS which would ultimately correspond to the Al2Cu crystal. Remarkably, rather than an increase, upon changing composition we find a small decrease in the LFS population, and the system remains impervious to nucleation of LFS crystals. We suggest that this may be related to the composition of the LFS, as only a limited subset is compatible with the crystal. We further demonstrate that the Al2Cu crystal will grow from a seed in the KA model with 2:1 composition and identify the melting temperature to be 0.447(2).

  19. A multivariate test of an expanded Andersen Health Care utilization model for complementary and alternative medicine (CAM) use in African Americans.

    PubMed

    Brown, Carolyn; Barner, Jamie; Bohman, Tom; Richards, Kristin

    2009-08-01

    The objectives of this study were (1) to determine which Andersen Model variables [predisposing, enabling, and need (PEN)] are related to complementary and alternative medicine (CAM) use by African Americans in the past 12 months; and (2) to determine whether the addition of disease states to the Model will explain significant variation in CAM use in the past 12 months. The 2002 National Health Interview Survey was used with 4256 African American adults (n = 23,828,268 weighted) selected as the study population. The dependent variable, CAM Past 12 Months, represented participants' use of at least 1 of 17 CAM modalities during the past 12 months. The Andersen Model variables [predisposing (e.g., age); enabling (e.g., insurance); and need (e.g., medical conditions)] and prevalent disease states (> or =10%) comprised the independent variables. Logistic regression analyses, incorporating the sampling weights, were employed. Among predisposing factors, CAM use was associated with middle-aged to older, more educated, and female African Americans. Region (Northeast less likely than South) was the only significant enabling factor. Need factors had the most frequent relationships, with more medical conditions, more physician visits, better health status, prescription and over-the-counter medication use, more frequent exercise, and having activities of daily living limitations being associated with CAM use. After adjusting for PEN factors, the disease states of pain/aching joints, recurring pain, and migraine were related to CAM use. African American CAM users are middle-aged to older, female, educated, and have more medical conditions (especially pain-related). Users report higher utilization of "traditional" care (e.g., physician visits), indicating that CAM is likely a complement to conventional treatment in this population. Health care providers should use these factors as prompts for inquiring about CAM use in African American patients.

  20. A Multivariate Test of an Expanded Andersen Health Care Utilization Model for Complementary and Alternative Medicine (CAM) Use in African Americans

    PubMed Central

    Barner, Jamie; Bohman, Tom; Richards, Kristin

    2009-01-01

    Abstract Objectives The objectives of this study were (1) to determine which Andersen Model variables [predisposing, enabling, and need (PEN)] are related to complementary and alternative medicine (CAM) use by African Americans in the past 12 months; and (2) to determine whether the addition of disease states to the Model will explain significant variation in CAM use in the past 12 months. Design The 2002 National Health Interview Survey was used with 4256 African American adults (n = 23,828,268 weighted) selected as the study population. The dependent variable, CAM Past 12 Months, represented participants' use of at least 1 of 17 CAM modalities during the past 12 months. The Andersen Model variables [predisposing (e.g., age); enabling (e.g., insurance); and need (e.g., medical conditions)] and prevalent disease states (≥10%) comprised the independent variables. Logistic regression analyses, incorporating the sampling weights, were employed. Results Among predisposing factors, CAM use was associated with middle-aged to older, more educated, and female African Americans. Region (Northeast less likely than South) was the only significant enabling factor. Need factors had the most frequent relationships, with more medical conditions, more physician visits, better health status, prescription and over-the-counter medication use, more frequent exercise, and having activities of daily living limitations being associated with CAM use. After adjusting for PEN factors, the disease states of pain/aching joints, recurring pain, and migraine were related to CAM use. Conclusions African American CAM users are middle-aged to older, female, educated, and have more medical conditions (especially pain-related). Users report higher utilization of “traditional” care (e.g., physician visits), indicating that CAM is likely a complement to conventional treatment in this population. Health care providers should use these factors as prompts for inquiring about CAM use in African

  1. Modeling survival: application of the Andersen-Gill model to Yellowstone grizzly bears

    USGS Publications Warehouse

    Johnson, Christopher J.; Boyce, Mark S.; Schwartz, Charles C.; Haroldson, Mark A.

    2004-01-01

     Wildlife ecologists often use the Kaplan-Meier procedure or Cox proportional hazards model to estimate survival rates, distributions, and magnitude of risk factors. The Andersen-Gill formulation (A-G) of the Cox proportional hazards model has seen limited application to mark-resight data but has a number of advantages, including the ability to accommodate left-censored data, time-varying covariates, multiple events, and discontinuous intervals of risks. We introduce the A-G model including structure of data, interpretation of results, and assessment of assumptions. We then apply the model to 22 years of radiotelemetry data for grizzly bears (Ursus arctos) of the Greater Yellowstone Grizzly Bear Recovery Zone in Montana, Idaho, and Wyoming, USA. We used Akaike's Information Criterion (AICc) and multi-model inference to assess a number of potentially useful predictive models relative to explanatory covariates for demography, human disturbance, and habitat. Using the most parsimonious models, we generated risk ratios, hypothetical survival curves, and a map of the spatial distribution of high-risk areas across the recovery zone. Our results were in agreement with past studies of mortality factors for Yellowstone grizzly bears. Holding other covariates constant, mortality was highest for bears that were subjected to repeated management actions and inhabited areas with high road densities outside Yellowstone National Park. Hazard models developed with covariates descriptive of foraging habitats were not the most parsimonious, but they suggested that high-elevation areas offered lower risks of mortality when compared to agricultural areas.

  2. An Enduring Shell Artefact Tradition from Timor-Leste: Oliva Bead Production from the Pleistocene to Late Holocene at Jerimalai, Lene Hara, and Matja Kuru 1 and 2

    PubMed Central

    O‘Connor, Sue

    2016-01-01

    In this paper, we describe 485 Oliva spp. shell beads recovered from four archaeological cave sites Jerimalai, Lene Hara, Matja Kuru 1, and Matja Kuru 2, located in Timor-Leste, Island Southeast Asia. While Pleistocene-aged examples of modified marine shells used for personal ornamentation are common in African and Eurasian assemblages, they are exceedingly rare in Southeast Asia, leading some researchers to suggest that these Modern Human societies were less complex than those found further west. In Timor-Leste, the lowest Oliva bead to be recovered was directly dated to ca. 37,000 cal. BP, making it the oldest piece of personal ornamentation in Southeast Asia. Morphometric, taphonomic, use wear, and residue analyses of these beads alongside modern reference specimens, and experimentally made examples indicate that the Oliva shells were modified to be strung consecutively (as in a necklace), and while their mode of production changed remarkably little over the thousands of years they were utilised, an increase in their deposition around 6,000 cal. BP suggests that there was a change in their use coinciding with sea-level stabilisation. These tiny beads demonstrate that early Island Southeast Asian societies produced the same kinds of symbolic material culture we have come to expect from the more intensively studied African/Eurasian region, and that limited sampling and poor recovery methods have biased our perspectives of this region. PMID:27537696

  3. Monitoring of bioaerosol inhalation risks in different environments using a six-stage Andersen sampler and the PCR-DGGE method.

    PubMed

    Xu, Zhenqiang; Yao, Maosheng

    2013-05-01

    Increasing evidences show that inhalation of indoor bioaerosols has caused numerous adverse health effects and diseases. However, the bioaerosol size distribution, composition, and concentration level, representing different inhalation risks, could vary with different living environments. The six-stage Andersen sampler is designed to simulate the sampling of different human lung regions. Here, the sampler was used in investigating the bioaerosol exposure in six different environments (student dorm, hospital, laboratory, hotel room, dining hall, and outdoor environment) in Beijing. During the sampling, the Andersen sampler was operated for 30 min for each sample, and three independent experiments were performed for each of the environments. The air samples collected onto each of the six stages of the sampler were incubated on agar plates directly at 26 °C, and the colony forming units (CFU) were manually counted and statistically corrected. In addition, the developed CFUs were washed off the agar plates and subjected to polymerase chain reaction (PCR)-denaturing gradient gel electrophoresis (DGGE) for diversity analysis. Results revealed that for most environments investigated, the culturable bacterial aerosol concentrations were higher than those of culturable fungal aerosols. The culturable bacterial and fungal aerosol fractions, concentration, size distribution, and diversity were shown to vary significantly with the sampling environments. PCR-DGGE analysis indicated that different environments had different culturable bacterial aerosol compositions as revealed by distinct gel band patterns. For most environments tested, larger (>3 μm) culturable bacterial aerosols with a skewed size distribution were shown to prevail, accounting for more than 60 %, while for culturable fungal aerosols with a normal size distribution, those 2.1-4.7 μm dominated, accounting for 20-40 %. Alternaria, Cladosporium, Chaetomium, and Aspergillus were found abundant in most

  4. Evaluation of passive diffusion bag samplers, dialysis samplers, and nylon-screen samplers in selected wells at Andersen Air Force Base, Guam, March-April 2002

    USGS Publications Warehouse

    Vroblesky, Don A.; Joshi, Manish; Morrell, Jeff; Peterson, J.E.

    2003-01-01

    During March-April 2002, the U.S. Geological Survey, Earth Tech, and EA Engineering, Science, and Technology, Inc., in cooperation with the Air Force Center for Environmental Excellence, tested diffusion samplers at Andersen Air Force Base, Guam. Samplers were deployed in three wells at the Main Base and two wells at Marianas Bonins (MARBO) Annex as potential ground-water monitoring alternatives. Prior to sampler deployment, the wells were tested using a borehole flowmeter to characterize vertical flow within each well. Three types of diffusion samplers were tested: passive diffusion bag (PDB) samplers, dialysis samplers, and nylon-screen samplers. The primary volatile organic compounds (VOCs) tested in ground water at Andersen Air Force Base were trichloroethene and tetrachloroethene. In most comparisons, trichloroethene and tetrachloroethene concentrations in PDB samples closely matched concentrations in pumped samples. Exceptions were in wells where the pumping or ambient flow produced vertical translocation of water in a chemically stratified aquifer. In these wells, PDB samplers probably would be a viable alternative sampling method if they were placed at appropriate depths. In the remaining three test wells, the trichloroethene or tetrachloroethene concentrations obtained with the diffusion samplers closely matched the result from pumped sampling. Chloride concentrations in nylon-screen samplers were compared with chloride concentrations in dialysis and pumped samples to test inorganic-solute diffusion into the samplers across a range of concentrations. The test showed that the results from nylon-screen samplers might have underestimated chloride concentrations at depths with elevated chloride concentrations. The reason for the discrepancy in this investigation is unknown, but may be related to nylon-screen-mesh size, which was smaller than that used in previous investigations.

  5. Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome)

    PubMed Central

    Tristani-Firouzi, Martin; Jensen, Judy L.; Donaldson, Matthew R.; Sansone, Valeria; Meola, Giovanni; Hahn, Angelika; Bendahhou, Said; Kwiecinski, Hubert; Fidzianska, Anna; Plaster, Nikki; Fu, Ying-Hui; Ptacek, Louis J.; Tawil, Rabi

    2002-01-01

    Andersen syndrome (AS) is a rare, inherited disorder characterized by periodic paralysis, long QT (LQT) with ventricular arrhythmias, and skeletal developmental abnormalities. We recently established that AS is caused by mutations in KCNJ2, which encodes the inward rectifier K+ channel Kir2.1. In this report, we characterized the functional consequences of three novel and seven previously described KCNJ2 mutations using a two-microelectrode voltage-clamp technique and correlated the findings with the clinical phenotype. All mutations resulted in loss of function and dominant-negative suppression of Kir2.1 channel function. In mutation carriers, the frequency of periodic paralysis was 64% and dysmorphic features 78%. LQT was the primary cardiac manifestation, present in 71% of KCNJ2 mutation carriers, with ventricular arrhythmias present in 64%. While arrhythmias were common, none of our subjects suffered sudden cardiac death. To gain insight into the mechanism of arrhythmia susceptibility, we simulated the effect of reduced Kir2.1 using a ventricular myocyte model. A reduction in Kir2.1 prolonged the terminal phase of the cardiac action potential, and in the setting of reduced extracellular K+, induced Na+/Ca2+ exchanger–dependent delayed afterdepolarizations and spontaneous arrhythmias. These findings suggest that the substrate for arrhythmia susceptibility in AS is distinct from the other forms of inherited LQT syndrome. PMID:12163457

  6. Sanger sequencing as a first-line approach for molecular diagnosis of Andersen-Tawil syndrome.

    PubMed

    Totomoch-Serra, Armando; Marquez, Manlio F; Cervantes-Barragán, David E

    2017-01-01

    In 1977, Frederick Sanger developed a new method for DNA sequencing based on the chain termination method, now known as the Sanger sequencing method (SSM).  Recently, massive parallel sequencing, better known as next-generation sequencing (NGS),  is replacing the SSM for detecting mutations in cardiovascular diseases with a genetic background. The present opinion article wants to remark that "targeted" SSM is still effective as a first-line approach for the molecular diagnosis of some specific conditions, as is the case for Andersen-Tawil syndrome (ATS). ATS is described as a rare multisystemic autosomal dominant channelopathy syndrome caused mainly by a heterozygous mutation in the KCNJ2 gene . KCJN2 has particular characteristics that make it attractive for "directed" SSM. KCNJ2 has a sequence of 17,510 base pairs (bp), and a short coding region with two exons (exon 1=166 bp and exon 2=5220 bp), half of the mutations are located in the C-terminal cytosolic domain, a mutational hotspot has been described in residue Arg218, and this gene explains the phenotype in 60% of ATS cases that fulfill all the clinical criteria of the disease. In order to increase the diagnosis of ATS we urge cardiologists to search for facial and muscular abnormalities in subjects with frequent ventricular arrhythmias (especially bigeminy) and prominent U waves on the electrocardiogram.

  7. Sanger sequencing as a first-line approach for molecular diagnosis of Andersen-Tawil syndrome

    PubMed Central

    Totomoch-Serra, Armando; Marquez, Manlio F.; Cervantes-Barragán, David E.

    2017-01-01

    In 1977, Frederick Sanger developed a new method for DNA sequencing based on the chain termination method, now known as the Sanger sequencing method (SSM).  Recently, massive parallel sequencing, better known as next-generation sequencing (NGS),  is replacing the SSM for detecting mutations in cardiovascular diseases with a genetic background. The present opinion article wants to remark that “targeted” SSM is still effective as a first-line approach for the molecular diagnosis of some specific conditions, as is the case for Andersen-Tawil syndrome (ATS). ATS is described as a rare multisystemic autosomal dominant channelopathy syndrome caused mainly by a heterozygous mutation in the KCNJ2 gene . KCJN2 has particular characteristics that make it attractive for “directed” SSM. KCNJ2 has a sequence of 17,510 base pairs (bp), and a short coding region with two exons (exon 1=166 bp and exon 2=5220 bp), half of the mutations are located in the C-terminal cytosolic domain, a mutational hotspot has been described in residue Arg218, and this gene explains the phenotype in 60% of ATS cases that fulfill all the clinical criteria of the disease. In order to increase the diagnosis of ATS we urge cardiologists to search for facial and muscular abnormalities in subjects with frequent ventricular arrhythmias (especially bigeminy) and prominent U waves on the electrocardiogram. PMID:29093808

  8. Predicting Help-Seeking Attitudes Toward Mental Health Services Among American Indian Older Adults: Is Andersen's Behavioral Model a Good Fit?

    PubMed

    Roh, Soonhee; Burnette, Catherine E; Lee, Kyoung Hag; Lee, Yeon-Shim; Martin, James I; Lawler, Michael J

    2017-01-01

    American Indian (AI) older adults are vulnerable to mental health disparities, yet very little is known about the factors associated with help-seeking for mental health services among them. The purpose of this study was to investigate the utility of Andersen's Behavioral Model in explaining AI older adults' help-seeking attitudes toward professional mental health services. Hierarchical regression analysis was used to examine predisposing, enabling, and need variables as predictors of help-seeking attitudes toward mental health services in a sample of 233 AI older adults from the Midwest. The model was found to have limited utility in the context of older AI help-seeking attitudes, as the proportion of explained variance was low. Gender, perceived stigma, social support, and physical health were significant predictors, whereas age, perceived mental health, and health insurance were not. © The Author(s) 2014.

  9. [Adjustment of the Andersen's model to the Mexican context: access to prenatal care].

    PubMed

    Tamez-González, Silvia; Valle-Arcos, Rosa Irene; Eibenschutz-Hartman, Catalina; Méndez-Ramírez, Ignacio

    2006-01-01

    The aim of this work was to propose an adjustment to the Model of Andersen who answers better to the social inequality of the population in the Mexico City and allows to evaluate the effect of socioeconomic factors in the access to the prenatal care of a sample stratified according to degree of marginalization. The data come from a study of 663 women, randomly selected from a framework sample of 21,421 homes in Mexico City. This work collects information about factors that affect utilization of health services, as well as predisposing factors (age and socioeconomic level), as enabling factors (education, social support, entitlement, pay out of pocket and opinion of health services), and need factors. The sample was ranked according to exclusion variables into three stratums. The data were analyzed through the technique of path analysis. The results indicate that socioeconomic level takes part like predisposed variable for utilization of prenatal care services into three stratums. Otherwise, education and social support were the most important enabling variables for utilization of prenatal care services in the same three groups. In regard to low stratum, the most important enabling variables were education and entitlement. For high stratum the principal enabling variables were pay out of pocket and social support. The medium stratum shows atypical behavior which it was difficult to explain and understand. There was not mediating role with need variable in three models. This indicated absence of equality in all stratums. However, the most correlations in high stratum perhaps indicate less inequitable conditions regarding other stratums.

  10. Application of the Andersen's health care utilization framework to secondary complications of spinal cord injury: a scoping review.

    PubMed

    Guilcher, Sara J T; Craven, B Cathy; McColl, Mary Ann; Lemieux-Charles, Louise; Casciaro, Tiziana; Jaglal, Susan B

    2012-01-01

    The purpose of this scoping review was to identify research priority areas related to secondary complications and associated health care use for individuals with spinal cord injury (SCI). Peer-reviewed journals were identified using CINAHL, MEDLINE, PubMed, Embase, Social Sciences Abstracts, Social Works Abstract and PsycInfo search engines. Key references were hand searched. A total of 289 abstracts were identified from the initial search strategy. We removed studies that did not measure health care and those that did not involve analytical investigation. The selected 31 studies were reviewed in detail using a coding template based on the domains and sub-components of the Andersen model (i.e. environmental, population characteristics, health behavior and outcome). Most studies measured predisposing characteristics (e.g., age, gender) and need characteristics (e.g., level of injury). There was a notable absence of environmental characteristics (e.g., health system, neighborhood variables), enabling characteristics and health behaviors (beyond diet and nutrition). We identified a gap in the SCI literature. Future research should focus on longitudinal study designs with more representation of non-traumatic spinal cord injury, as well as utilizing more advanced statistical analyses (i.e., multivariate level) to adjust for confounding variables.

  11. Dynamic and thermodynamic crossover scenarios in the Kob-Andersen mixture: Insights from multi-CPU and multi-GPU simulations.

    PubMed

    Coslovich, Daniele; Ozawa, Misaki; Kob, Walter

    2018-05-17

    The physical behavior of glass-forming liquids presents complex features of both dynamic and thermodynamic nature. Some studies indicate the presence of thermodynamic anomalies and of crossovers in the dynamic properties, but their origin and degree of universality is difficult to assess. Moreover, conventional simulations are barely able to cover the range of temperatures at which these crossovers usually occur. To address these issues, we simulate the Kob-Andersen Lennard-Jones mixture using efficient protocols based on multi-CPU and multi-GPU parallel tempering. Our setup enables us to probe the thermodynamics and dynamics of the liquid at equilibrium well below the critical temperature of the mode-coupling theory, [Formula: see text]. We find that below [Formula: see text] the analysis is hampered by partial crystallization of the metastable liquid, which nucleates extended regions populated by large particles arranged in an fcc structure. By filtering out crystalline samples, we reveal that the specific heat grows in a regular manner down to [Formula: see text] . Possible thermodynamic anomalies suggested by previous studies can thus occur only in a region of the phase diagram where the system is highly metastable. Using the equilibrium configurations obtained from the parallel tempering simulations, we perform molecular dynamics and Monte Carlo simulations to probe the equilibrium dynamics down to [Formula: see text]. A temperature-derivative analysis of the relaxation time and diffusion data allows us to assess different dynamic scenarios around [Formula: see text]. Hints of a dynamic crossover come from analysis of the four-point dynamic susceptibility. Finally, we discuss possible future numerical strategies to clarify the nature of crossover phenomena in glass-forming liquids.

  12. Efficacy and safety of flecainide for ventricular arrhythmias in patients with Andersen-Tawil syndrome with KCNJ2 mutations.

    PubMed

    Miyamoto, Koji; Aiba, Takeshi; Kimura, Hiromi; Hayashi, Hideki; Ohno, Seiko; Yasuoka, Chie; Tanioka, Yoshihito; Tsuchiya, Takeshi; Yoshida, Yoko; Hayashi, Hiroshi; Tsuboi, Ippei; Nakajima, Ikutaro; Ishibashi, Kohei; Okamura, Hideo; Noda, Takashi; Ishihara, Masaharu; Anzai, Toshihisa; Yasuda, Satoshi; Miyamoto, Yoshihiro; Kamakura, Shiro; Kusano, Kengo; Ogawa, Hisao; Horie, Minoru; Shimizu, Wataru

    2015-03-01

    Andersen-Tawil syndrome (ATS) is an autosomal dominant genetic or sporadic disorder characterized by ventricular arrhythmias (VAs), periodic paralyses, and dysmorphic features. The optimal pharmacological treatment of VAs in patients with ATS remains unknown. We evaluated the efficacy and safety of flecainide for VAs in patients with ATS with KCNJ2 mutations. Ten ATS probands (7 females; mean age 27 ± 11 years) were enrolled from 6 institutions. All of them had bidirectional VAs in spite of treatment with β-blockers (n = 6), but none of them had either aborted cardiac arrest or family history of sudden cardiac death. Twenty-four-hour Holter recording and treadmill exercise test (TMT) were performed before (baseline) and after oral flecainide therapy (150 ± 46 mg/d). Twenty-four-hour Holter recordings demonstrated that oral flecainide treatment significantly reduced the total number of VAs (from 38,407 ± 19,956 to 11,196 ± 14,773 per day; P = .003) and the number of the longest ventricular salvos (23 ± 19 to 5 ± 5; P = .01). At baseline, TMT induced nonsustained ventricular tachycardia (n = 7) or couplets of premature ventricular complex (n = 2); treatment with flecainide completely (n = 7) or partially (n = 2) suppressed these exercise-induced VAs (P = .008). In contrast, the QRS duration, QT interval, and U-wave amplitude of the electrocardiogram were not altered by flecainide therapy. During a mean follow-up of 23 ± 11 months, no patients developed syncope or cardiac arrest after oral flecainide treatment. This multicenter study suggests that oral flecainide therapy is an effective and safe means of suppressing VAs in patients with ATS with KCNJ2 mutations, though the U-wave amplitude remained unchanged by flecainide. Copyright © 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  13. Computation and Modeling of Insect Flight

    DTIC Science & Technology

    2005-08-23

    Andersen, U. Pesavento , and Z. J. Wang, J. Fluid Mech., 2005. A. Andersen, U. Pesavento , and Z. J. Wang, J. Fluid Mech., 2005. U, Pasavento and Z. J...Wang (P.I.) "* Umberto Pesavento , PhD Physics (2005), Cornell University "* Anders Andersen, 2002-2005, Postdoctoral Fellow "* Sheng Xu, 2003-2006...press. 3. Anders Andersen, Umberto Pesavento , and Z. Jane Wang, ’Unsteady Aerodynamics of Fluttering and Tumbling Plates’, Journal of Fluid Mechanics

  14. 17 CFR 230.437a - Written consents.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Are filing a registration statement containing financial statements in which Arthur Andersen LLP (or a foreign affiliate of Arthur Andersen LLP) had been acting as the independent public accountant. (b... dispense with the requirement for the registrant to file the written consent of Arthur Andersen LLP (or a...

  15. Biophysical and Molecular Characterization of a Novel de novo KCNJ2 Mutation Associated with Andersen-Tawil Syndrome and CPVT Mimicry

    PubMed Central

    Barajas-Martinez, Hector; Hu, Dan; Ontiveros, Gustavo; Caceres, Gabriel; Desai, Mayurika; Burashnikov, Elena; Scaglione, Jorge; Antzelevitch, Charles

    2010-01-01

    Background Mutations in KCNJ2, the gene encoding the human inward rectifier potassium channel Kir2.1 (IK1 or IKir2.1), have been identified in Andersen-Tawil syndrome (ATS). ATS is a multisystem inherited disease exhibiting periodic paralysis, cardiac arrhythmias, and dysmorphic features at times mimicking catecholaminergic polymorphic ventricular tachycardia (CPVT). Methods and Results Our proband displayed dysmorphic features including micrognathia, clinodactyly and syndactyly, and exhibited multiform extrasystoles and bidirectional ventricular tachycardia both at rest and during exercise testing. The patient’s symptoms continued following administration of nadolol, but subsided after treatment with flecainide. Molecular genetic screening revealed a novel heterozygous mutation (c.779G>C/p.R260P) in KCNJ2. Whole-cell patch-clamp studies conducted in TSA201 cells transfected with wild type human KCNJ2 cDNA (WT-KCNJ2) yielded robust IKir2.1, but no measurable current in cells expressing the R260P mutant. Co-expression of WT and R260P-KCNJ2 (heterozygous expression) yielded a markedly reduced inward IKir2.1 compared with WT alone (−36.5±9.8 pA/pF vs. −143.5±11.4 pA/pF, n=8 for both, P<0.001, respectively at −90 mV) indicating a strong dominant negative effect of the mutant. The outward component of IKir2.1 measured at −50 mV was also markedly reduced with the heterozygous expression vs. WT (0.52±5.5 pA/pF vs. 23.4±6.7 pA/pF, n=8 for both, P<0.001, respectively). Immunocytochemical analysis indicates that impaired trafficking of R260P-KCNJ2 channels. Conclusions We report a novel de novo KCNJ2 mutation associated with classical phenotypic features of ATS and CPVT mimicry. The R260P mutation produces a strong dominant negative effect leading to marked suppression of IK1 secondary to a trafficking defect. PMID:21148745

  16. Anatomic Distribution and Mortality of Arterial Injury in the Wars in Afghanistan and Iraq with Comparison to a Civilian Benchmark

    DTIC Science & Technology

    2012-09-01

    549-55; discussion: 555-6. 40. Arthurs ZM, Starnes BW, Sohn VY, Singh N, Martin MJ, Andersen CA. Functional and survival outcomes in traumatic blunt...trauma. J Vasc Surg 2005;41:638-44. 21. Starnes BW, Beekley AC, Sebesta JA, Andersen CA, Rush RM Jr. Extremity vascular injuries on the battlefield...Surg 2007;46:1222-6. 35. Mullenix PS, Steele SR, Andersen CA, Starnes BW, Salim A, Martin MJ. Limb salvage and outcomes among patients with traumatic

  17. Effect of drug load and plate coating on the particle size distribution of a commercial albuterol metered dose inhaler (MDI) determined using the Andersen and Marple-Miller cascade impactors.

    PubMed

    Nasr, M M; Ross, D L; Miller, N C

    1997-10-01

    The purpose of this study is to investigate the effect of drug load, the coating of impactor stages, and the design of cascade impactors on albuterol MDIs particle size distribution measurements. The results of the investigation will be used to explain the "loading effect" recently reported. Particle size distribution parameters of a commercial albuterol MDI were measured using both Andersen (AI) and Marple-Miller (MMI) Cascade Impactors, where plates were either left uncoated or coated with silicone or glycerin. A previously validated HPLC-EC method was used for the assay of albuterol collected by the impactor and in single spray content determinations. Coating impactor collection plates had an impact on measured MMAD and GSD values for single puff measurements but very little or no effect for the multi puff measurements. Due to particle bounce, the percent of albuterol fine particles deposited in the filter and impactor finer stages (< 1.10 microns in AI and < 1.25 microns in MMI) in uncoated single puff experiments was much higher in comparison to either coated single puff or multi-puff (coated and uncoated) measurements. Evaluation of drug load and plate coating are necessary to determine whether observed particle size distributions are representative of the generated aerosol or are the result of particle bounce and reentrainment. In order to minimize particle bounce, especially for single puff determinations, it may be useful to apply a thin layer of a sticky coating agent to the surfaces of impactor plates.

  18. Prospective Evaluation of Mental Health and Deployment Experience Among Women in the US Military

    DTIC Science & Technology

    2012-07-06

    Beverly Sheppard, Katherine Snell, Steven Speigle, Kari Sausedo, Jennifer Walstrom, Martin White, James Whitmer, and Char- lene Wong; Madigan Army Medical...what physicians should know. J Gen Intern Med. 2006; 21(suppl 3):S5–S10. 13. Lindstrom KE, Smith TC, Wells TS, et al. The mental health of U.S

  19. Relative precision of inhaler aerodynamic particle size distribution (APSD) metrics by full resolution and abbreviated andersen cascade impactors (ACIs): part 2--investigation of bias in extra-fine mass fraction with AIM-HRT impactor.

    PubMed

    Mitchell, Jolyon P; Nagel, Mark W; Doyle, Cathy C; Ali, Rubina S; Avvakoumova, Valentina I; Christopher, J David; Quiroz, Jorge; Strickland, Helen; Tougas, Terrence; Lyapustina, Svetlana

    2010-09-01

    The purpose of this study was to resolve an anomalously high measure of extra-fine particle fraction (EPF) determined by the abbreviated cascade impactor possibly relevant for human respiratory tract (AIM-HRT) in the experiment described in Part 1 of this two-part series, in which the relative precision of abbreviated impactors was evaluated in comparison with a full resolution Andersen eight-stage cascade impactor (ACI). Evidence that the surface coating used to mitigate particle bounce was laterally displaced by the flow emerging from the jets of the lower stage was apparent upon microscopic examination of the associated collection plate of the AIM-HRT impactor whose cut point size defines EPF. A filter soaked in surfactant was floated on top of this collection plate, and further measurements were made using the same pressurized metered-dose inhaler-based formulation and following the same procedure as in Part 1. Measures of EPF, fine particle, and coarse particle fractions were comparable with those obtained with the ACI, indicating that the cause of the bias had been identified and removed. When working with abbreviated impactors, this precaution is advised whenever there is evidence that surface coating displacement has occurred, a task that can be readily accomplished by microscopic inspection of all collection plates after allowing the impactor to sample ambient air for a few minutes.

  20. Modelling of Nearshore Sediment Transport

    DTIC Science & Technology

    1990-03-01

    dimensional, consisting of the vertical motion of a layer of sand, as modeled for example by Fredsoe, Andersen, and Silberg (1985). The scales of the...Andersen. and S. Silberg . 1985. Distribution of suspended sediment in large waves. J. Waterwav. Port Coastal. Ocean Div., 111 (6). 1041-1059. Gillie. R. D

  1. Helping Adults Learn To Deliver Value in a Global Society.

    ERIC Educational Resources Information Center

    Montgomery, Joel R.

    Andersen Consulting is a global management and technology consulting organization whose mission is to boost clients' success by teaching them to link strategy, people, processes, and technology. Andersen's professional development program for its own 41,000-person global work force is designed to help adults learn to deliver value to global…

  2. Landfill Liners and Covers: Properties and Application to Army Landfills.

    DTIC Science & Technology

    1984-06-01

    polymers, TPE can be seamed by heat techniques. Materials such as thermoplastic EPDM and nitrile rubber /PVC blends are still being tested to determine their...such as polyethylene (PE), polyvinyl chloride (PVC), butyl rubber , ethylene propylene diene monomer ( EPDM ), chlorinated polyethylene (CPE), and others...chlorosulfonated polyethy- lene (CSPE), chlorinated polyethylene (CPE), butyl rubber , ethylene propylene S rubber ( EPDM ), neoprene, high-density polyethylene

  3. Rational Inhibitors of DNA Base Excision Repair Enzymes: New Tools for Elucidating the Role of BER in Cancer Chemotherapy

    DTIC Science & Technology

    2006-05-01

    2005, 7, 493-500. (30) Nilsen, H.; Rosewell , I.; Robins, P.; Skjelbred, C. F.; Andersen, S.; Slupphaug, G.; Daly, G.; Krokan, H. E.; Lindahl, T.; Barnes...Cell Biol. 2005, 7, 493–500. 31. Nilsen, H.; Rosewell , I.; Robins, P.; Skjelbred, C. F.; Andersen, S.; Slupphaug, G.; Daly, G.; Krokan, H. E

  4. Transitioning NWChem to the Next Generation of Manycore Machines

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bylaska, Eric J.; Apra, Edoardo; Kowalski, Karol

    The NorthWest Chemistry (NWChem) modeling software is a popular molecular chemistry simulation software that was designed from the start to work on massively parallel processing supercomputers[6, 28, 49]. It contains an umbrella of modules that today includes Self Consistent Field (SCF), second order Mller-Plesset perturbation theory (MP2), Coupled Cluster, multi-conguration selfconsistent eld (MCSCF), selected conguration interaction (CI), tensor contraction engine (TCE) many body methods, density functional theory (DFT), time-dependent density functional theory (TDDFT), real time time-dependent density functional theory, pseudopotential plane-wave density functional theory (PSPW), band structure (BAND), ab initio molecular dynamics, Car-Parrinello molecular dynamics, classical molecular dynamics (MD), QM/MM,more » AIMD/MM, GIAO NMR, COSMO, COSMO-SMD, and RISM solvation models, free energy simulations, reaction path optimization, parallel in time, among other capabilities[ 22]. Moreover new capabilities continue to be added with each new release.« less

  5. The Equations of Oceanic Motions

    NASA Astrophysics Data System (ADS)

    Müller, Peter

    2006-10-01

    Modeling and prediction of oceanographic phenomena and climate is based on the integration of dynamic equations. The Equations of Oceanic Motions derives and systematically classifies the most common dynamic equations used in physical oceanography, from large scale thermohaline circulations to those governing small scale motions and turbulence. After establishing the basic dynamical equations that describe all oceanic motions, M|ller then derives approximate equations, emphasizing the assumptions made and physical processes eliminated. He distinguishes between geometric, thermodynamic and dynamic approximations and between the acoustic, gravity, vortical and temperature-salinity modes of motion. Basic concepts and formulae of equilibrium thermodynamics, vector and tensor calculus, curvilinear coordinate systems, and the kinematics of fluid motion and wave propagation are covered in appendices. Providing the basic theoretical background for graduate students and researchers of physical oceanography and climate science, this book will serve as both a comprehensive text and an essential reference.

  6. The Acquisition of Tense-Aspect in Child Second Language English

    ERIC Educational Resources Information Center

    Haznedar, Belma

    2007-01-01

    The aim of this article is two-fold: to test the Aspect Hypothesis, according to which the early use of tense-aspect morphology patterns by semantic/aspectual features of verbs, and Tense is initially defective (e.g. Antinucci and Miller, 1976; Bloom et al., 1980; Andersen and Shirai, 1994; 1996; Robison, 1995; Shirai and Andersen, 1995;…

  7. 40 CFR Table B-3 to Subpart B of... - Interferent Test Concentration, 1 Parts per Million

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Nitric oxide Carbon dioxide Ethylene Ozone Mxy-lene Water vapor Carbon monoxide Methane Ethane... 4 0.14 750 3 20,000 50 SO2 Gas chromatography 0.1 4 0.14 750 3 20,000 50 SO2 Spectrophotometric-wet... 0.5 3 20,000 SO2 Conductivity 0.2 0.1 4 0.14 0.5 750 SO2 Spectrophotometric-gas phase, including...

  8. Physical and Chemical Processes in Flames

    DTIC Science & Technology

    2010-02-15

    7. "An efficient reduced mechanism for methane oxidation with NOx chemistry ," by T. F. Lu and C. K. Law, Paper No. C17, Fifth US Combustion Meeting... Mechanical and Aerospace Engineering Princeton University Princeton, NJ 08544 9. SPONSORING I MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR...TERMS Laminar flame speeds; ignition temperatures; extinction limits; mechanism reduction; skeletal mechanism ; CO/H2 oxidation; ethy lene oxidation

  9. Trehalose Dimycolate Enhances Survival of Fission Neutron-Irradiated Mice and Klebsiella pneumoniae-Challenged Irradiated Mice

    DTIC Science & Technology

    1990-01-01

    SR90-5 Trehalose Dimycolate Enhances Survival of Fission Neutron-Irradiated Mice and Kiebsiella pneumoniae-Challenged Irradiated Mice 1’ 2 D. (. M...doses kines and immunomodulators of nonspecific resistance to of fission neutron radiation is increased when trehalose dimycol- infection might have... trehalose day before exposure to radiation. TDM in an emulsion of squa- dimycolate (TDM) have been shown to be effective in in- lene. Tween 80, and saline

  10. Evaluation of three portable samplers for monitoring airborne fungi

    NASA Technical Reports Server (NTRS)

    Mehta, S. K.; Mishra, S. K.; Pierson, D. L.

    1996-01-01

    Airborne fungi were monitored at five sample sites with the Burkard portable, the RCS Plus, and the SAS Super 90 air samplers; the Andersen 2-stage impactor was used for comparison. All samplers were calibrated before being used simultaneously to collect 100-liter samples at each site. The Andersen and Burkard samplers retrieved equivalent volumes of airborne fungi; the SAS Super 90 and RCS Plus measurements did not differ from each other but were significantly lower than those obtained with the Andersen or Burkard samplers. Total fungal counts correlated linearly with Cladosporium and Penicillium counts. Alternaria species, although present at all sites, did not correlate with total count or with amounts of any other fungal genera. Sampler and location significantly influenced fungal counts, but no interactions between samplers and locations were found.

  11. Evaluation of particulate air samplers for airborne aflatoxin B1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Silas, J.C.; Harrison, M.A.; Carpenter, J.A.

    Five air samplers (Millipore, all-glass impinger, centrifugal, Andersen, and absorbent cotton) were evaluated for their ability to collect airborne grain particles contaminated with aflatoxin B1. Corn dust containing 100 micrograms aflatoxin B1/g was aerosolized within a containment system. Each device sampled 100 I air, thus exchanging the air in the chamber two times. Aflatoxin B1 was extracted from all sampling matrices and was detected and quantitated with thin-layer chromatography and scanning fluorodensitometry. The highest efficiency was obtained with the Millipore sampler, while the efficiencies of the centrifugal and the cotton samplers were almost identical. Efficiency of an Andersen was less,more » with no toxin recovered from an all-glass impinger. Measurement of particle size was accomplished with the Andersen sampler.« less

  12. Effect of sampling volume on dry powder inhaler (DPI)-emitted aerosol aerodynamic particle size distributions (APSDs) measured by the Next-Generation Pharmaceutical Impactor (NGI) and the Andersen eight-stage cascade impactor (ACI).

    PubMed

    Mohammed, Hlack; Roberts, Daryl L; Copley, Mark; Hammond, Mark; Nichols, Steven C; Mitchell, Jolyon P

    2012-09-01

    Current pharmacopeial methods for testing dry powder inhalers (DPIs) require that 4.0 L be drawn through the inhaler to quantify aerodynamic particle size distribution of "inhaled" particles. This volume comfortably exceeds the internal dead volume of the Andersen eight-stage cascade impactor (ACI) and Next Generation pharmaceutical Impactor (NGI) as designated multistage cascade impactors. Two DPIs, the second (DPI-B) having similar resistance than the first (DPI-A) were used to evaluate ACI and NGI performance at 60 L/min following the methodology described in the European and United States Pharmacopeias. At sampling times ≥2 s (equivalent to volumes ≥2.0 L), both impactors provided consistent measures of therapeutically important fine particle mass (FPM) from both DPIs, independent of sample duration. At shorter sample times, FPM decreased substantially with the NGI, indicative of incomplete aerosol bolus transfer through the system whose dead space was 2.025 L. However, the ACI provided consistent measures of both variables across the range of sampled volumes evaluated, even when this volume was less than 50% of its internal dead space of 1.155 L. Such behavior may be indicative of maldistribution of the flow profile from the relatively narrow exit of the induction port to the uppermost stage of the impactor at start-up. An explanation of the ACI anomalous behavior from first principles requires resolution of the rapidly changing unsteady flow and pressure conditions at start up, and is the subject of ongoing research by the European Pharmaceutical Aerosol Group. Meanwhile, these experimental findings are provided to advocate a prudent approach by retaining the current pharmacopeial methodology.

  13. 40 CFR 721.3560 - Derivative of tetra-chloro-ethy-lene.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... according to procedures established by the Occupational Safety and Health Administration and Mine Safety and Health Administration regulations and set forth at 29 CFR 1910.134, and 30 CFR part 11, respectively, and... including the duration of exposure, associated chemical substances, chemical and mechanical stresses, and...

  14. The pathophysiological mechanisms of the onset of death through accidental hypothermia and the presentation of "The little match girl" case.

    PubMed

    Jeican, Ionuţ Isaia

    2014-01-01

    Hypothermia and death caused by hypothermia may be found in a number of fiction works, mainly in novels. In the well-known story "The Little Match Girl" by Hans Christian Andersen, one can notice that the descriptions of the phenomena occurring before the girl's death are in fact a literary presentation of the pathophysiological mechanisms of the onset of death through accidental hypothermia. This essay presents the medical aspects of the story written by Andersen.

  15. Angularly symmetric splitting of a light beam upon reflection and refraction at an air-dielectric plane boundary: reply.

    PubMed

    Azzam, R M A

    2016-05-01

    The simplified explicit expressions derived by Andersen [J. Opt. Soc. Am. A33, 984 (2016)JOAOD60740-323210.1364/JOSAA.32.000984], that relate to angularly symmetric beam splitting by reflection and refraction at an air-dielectric interface recently described by Azzam [J. Opt. Soc. Am. A32, 2436 (2015)JOAOD60740-323210.1364/JOSAA.32.002436], are welcome. A few additional remarks are also included in my reply to Andersen's comment.

  16. The pathophysiological mechanisms of the onset of death through accidental hypothermia and the presentation of “The little match girl” case

    PubMed Central

    JEICAN, IONUŢ ISAIA

    2014-01-01

    Hypothermia and death caused by hypothermia may be found in a number of fiction works, mainly in novels. In the well-known story “The Little Match Girl” by Hans Christian Andersen, one can notice that the descriptions of the phenomena occurring before the girl’s death are in fact a literary presentation of the pathophysiological mechanisms of the onset of death through accidental hypothermia. This essay presents the medical aspects of the story written by Andersen. PMID:26527999

  17. A Ballistic Material Model for Cross-Plied Unidirectional Ultra-High Molecular-Weight Polyethylene Fiber-Reinforced Armor-Grade Composites

    DTIC Science & Technology

    2008-01-01

    strength polymeric fibers such as aramid (e.g. Kevlar ®, Twaron®, etc.) or oriented polyethy- lene fibers (e.g. Spectra®, Dyneema®, etc.) with an... phenolic -poly-vinyl-butyral resin and on 0◦/90◦ cross- plied oriented polyethylene fiber-reinforced vinyl-ester resin are widely used in hard personnel...are: (a) poly-aramids (e.g. Kevlar ®, Twaron®, Technora®); (b) highly oriented ultra-highmolecular-weight polyethylene, UHMWPE (e.g. Spectra®, Dyneema

  18. Aerodynamic particle size analysis of aerosols from pressurized metered-dose inhalers: comparison of Andersen 8-stage cascade impactor, next generation pharmaceutical impactor, and model 3321 Aerodynamic Particle Sizer aerosol spectrometer.

    PubMed

    Mitchell, Jolyon P; Nagel, Mark W; Wiersema, Kimberly J; Doyle, Cathy C

    2003-10-22

    The purpose of this research was to compare three different methods for the aerodynamic assessment of (1) chloroflurocarbon (CFC)--fluticasone propionate (Flovent), (2) CFC-sodium cromoglycate (Intal), and (3) hydrofluoroalkane (HFA)--beclomethasone dipropionate (Qvar) delivered by pressurized metered dose inhaler. Particle size distributions were compared determining mass median aerodynamic diameter (MMAD), geometric standard deviation (GSD), and fine particle fraction <4.7 microm aerodynamic diameter (FPF(<4.7 microm)). Next Generation Pharmaceutical Impactor (NGI)-size distributions for Flovent comprised finer particles than determined by Andersen 8-stage impactor (ACI) (MMAD = 2.0 +/- 0.05 micro m [NGI]; 2.8 +/- 0.07 microm [ACI]); however, FPF(<4.7 microm) by both impactors was in the narrow range 88% to 93%. Size distribution agreement for Intal was better (MMAD = 4.3 +/- 0.19 microm (NGI), 4.2 +/- 0.13 microm (ACI), with FPF(<4.7 microm) ranging from 52% to 60%. The Aerodynamic Particle Sizer (APS) undersized aerosols produced with either formulation (MMAD = 1.8 +/- 0.07 micro m and 3.2 +/- 0.02 micro m for Flovent and Intal, respectively), but values of FPF(<4.7 microm)from the single-stage impactor (SSI) located at the inlet to the APS (82.9% +/- 2.1% [Flovent], 46.4% +/- 2.4% [Intal]) were fairly close to corresponding data from the multi-stage impactors. APS-measured size distributions for Qvar (MMAD = 1.0 +/- 0.03 micro m; FPF(<4.7 micro m)= 96.4% +/- 2.5%), were in fair agreement with both NGI (MMAD = 0.9 +/- 0.03 micro m; FPF(<4.7 microm)= 96.7% +/- 0.7%), and ACI (MMAD = 1.2 +/- 0.02 microm, FPF(<4.7 microm)= 98% +/- 0.5%), but FPF(<4.7 microm) from the SSI (67.1% +/- 4.1%) was lower than expected, based on equivalent data obtained by the other techniques. Particle bounce, incomplete evaporation of volatile constituents and the presence of surfactant particles are factors that may be responsible for discrepancies between the techniques.

  19. Towards a Comprehensive Approach to the Analysis of Categorical Data.

    DTIC Science & Technology

    1983-06-01

    have made methodological contributions to the topic include R.L. Anderson, K. Hinkelman, 0. Kempthorne, and K. Koehler . The next section of this paper...their sufficient statistics that originated in the 1930’s with Fisher (e.g. see Dempster, 1971, and the discussion in Andersen. 1980 ). From the...ones from the original density for which h, h, .... h are MSS’s, and h ,h. h are the corresponding MSS’s in the conditional density (see Andersen, 1980

  20. [A simple testing installation for the production of aerosols with constant bacteria-contaminated concentrations].

    PubMed

    Herbst, M; Lehmhus, H; Oldenburg, B; Orlowski, C; Ohgke, H

    1983-04-01

    A simple experimental set for the production and investigation of bacterially contaminated solid-state aerosols with constant concentration is described. The experimental set consists mainly of a fluidized bed-particle generator within a modified chamber for formaldehyde desinfection. The special conditions for the production of a defined concentration of particles and microorganisms are to be found out empirically. In a first application aerosol-sizing of an Andersen sampler is investigated. The findings of Andersen (1) are confirmed with respect to our experimental conditions.

  1. Controlled-Release Personal Use Arthropod Repellent Formulation. Phase 3

    DTIC Science & Technology

    1987-08-26

    Polyethylene Glycol (200) Glyceryl Monotallowate (Varonic L1420) 54.2 lbs. Glyceryl Stearate/ Sodium Lauryl Sulfate (Lexemul AS) 129.3 lbs. Propylene... Sulfate 6-0 Xr ________ (Le.ernul AS) - 0.65__ * 13W00 Cetyl Palmitate (W,xenol 816) 2,600 Xg. Ci Zq! 167 2.2___ 10026 Poyproplen Gycol (15) Stenryl...1 Stearate7Sodium lAu 1l Sulfate T- 4fIa- TW _ - ________ Lex emul AS)__________ ____ _______ 2.41 11315 /Prop lene Glycol D1 cap" lateDf~caerate

  2. Metabolic Regulation of Caspase 2 in Breast Cancer

    DTIC Science & Technology

    2009-04-01

    Darbandi, Sook-Young Yoon, Judy Q. Wu, Yuko J. Miyamoto2 Jennifer A. Gibbon, Josh L. Andersen, Christopher D. Freel, Wanli Tang, Changli He, Manabu...Darbandi1, Sook-Young Yoon3, Judy Q. Wu1, Yuko J. Miyamoto2, Jennifer A. Gibbon1, Josh L. Andersen1, Christopher D. Freel1, Wanli Tang1, Changli He3...Altman, B.J., Coloff, J.L., Herman, C.E., Jacobs, S.R., Wieman, H.L., Wofford , J.A., Dimascio, L.N., Ilkayeva, O., Kelekar, A., et al. (2007

  3. A concurrent multiscale micromorphic molecular dynamics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Shaofan, E-mail: shaofan@berkeley.edu; Tong, Qi

    2015-04-21

    In this work, we have derived a multiscale micromorphic molecular dynamics (MMMD) from first principle to extend the (Andersen)-Parrinello-Rahman molecular dynamics to mesoscale and continuum scale. The multiscale micromorphic molecular dynamics is a con-current three-scale dynamics that couples a fine scale molecular dynamics, a mesoscale micromorphic dynamics, and a macroscale nonlocal particle dynamics together. By choosing proper statistical closure conditions, we have shown that the original Andersen-Parrinello-Rahman molecular dynamics is the homogeneous and equilibrium case of the proposed multiscale micromorphic molecular dynamics. In specific, we have shown that the Andersen-Parrinello-Rahman molecular dynamics can be rigorously formulated and justified from firstmore » principle, and its general inhomogeneous case, i.e., the three scale con-current multiscale micromorphic molecular dynamics can take into account of macroscale continuum mechanics boundary condition without the limitation of atomistic boundary condition or periodic boundary conditions. The discovered multiscale scale structure and the corresponding multiscale dynamics reveal a seamless transition from atomistic scale to continuum scale and the intrinsic coupling mechanism among them based on first principle formulation.« less

  4. Evaluation of portable air samplers for monitoring airborne culturable bacteria

    NASA Technical Reports Server (NTRS)

    Mehta, S. K.; Bell-Robinson, D. M.; Groves, T. O.; Stetzenbach, L. D.; Pierson, D. L.

    2000-01-01

    Airborne culturable bacteria were monitored at five locations (three in an office/laboratory building and two in a private residence) in a series of experiments designed to compare the efficiency of four air samplers: the Andersen two-stage, Burkard portable, RCS Plus, and SAS Super 90 samplers. A total of 280 samples was collected. The four samplers were operated simultaneously, each sampling 100 L of air with collection on trypticase soy agar. The data were corrected by applying positive hole conversion factors for the Burkard portable, Andersen two-stage, and SAS Super 90 air samplers, and were expressed as log10 values prior to statistical analysis by analysis of variance. The Burkard portable air sampler retrieved the highest number of airborne culturable bacteria at four of the five sampling sites, followed by the SAS Super 90 and the Andersen two-stage impactor. The number of bacteria retrieved by the RCS Plus was significantly less than those retrieved by the other samplers. Among the predominant bacterial genera retrieved by all samplers were Staphylococcus, Bacillus, Corynebacterium, Micrococcus, and Streptococcus.

  5. Aging, longevity and health

    PubMed Central

    Rasmussen, Lene Juel; Sander, Miriam; Wewer, Ulla M.; Bohr, Vilhelm A.

    2016-01-01

    The IARU Congress on Aging, Longevity and Health, held on 5–7 October 2010 in Copenhagen, Denmark, was hosted by Rector Ralf Hemmingsen, University of Copenhagen and Dean Ulla Wewer, Faculty of Health Sciences, University of Copenhagen and was organized by Center for Healthy Aging (CEHA) under the leadership of CEHA Managing Director Lene Juel Rasmussen and Prof. Vilhelm Bohr, National Institute on Aging, NIH, Baltimore, USA (associated to CEHA). The Congress was attended by approximately 125 researchers interested in and/or conducting research on aging and aging-related topics. The opening Congress Session included speeches by Ralf Hemmingsen, Ulla Wewer, and Lene Juel Rasmussen and Keynote Addresses by four world renowned aging researchers: Povl Riis (The Age Forum), Bernard Jeune (University of Southern Denmark), George Martin (University of Washington, USA) and Jan Vijg (Albert Einstein School of Medicine, USA) as well as a lecture discussing the art-science interface by Thomas Söderqvist (Director, Medical Museion, University of Copenhagen). The topics of the first six Sessions of the Congress were: Neuroscience and DNA damage, Aging and Stress, Life Course, Environmental Factors and Neuroscience, Muscle and Life Span and Life Span and Mechanisms. Two additional Sessions highlighted ongoing research in the recently established Center for Healthy Aging at the University of Copenhagen. This report highlights outcomes of recent research on aging-related topics, as described at the IARU Congress on Aging, Longevity and Health. PMID:21820462

  6. Aging, longevity and health.

    PubMed

    Rasmussen, Lene Juel; Sander, Miriam; Wewer, Ulla M; Bohr, Vilhelm A

    2011-10-01

    The IARU Congress on Aging, Longevity and Health, held on 5-7 October 2010 in Copenhagen, Denmark, was hosted by Rector Ralf Hemmingsen, University of Copenhagen and Dean Ulla Wewer, Faculty of Health Sciences, University of Copenhagen and was organized by Center for Healthy Aging (CEHA) under the leadership of CEHA Managing Director Lene Juel Rasmussen and Prof. Vilhelm Bohr, National Institute on Aging, NIH, Baltimore, USA (associated to CEHA). The Congress was attended by approximately 125 researchers interested in and/or conducting research on aging and aging-related topics. The opening Congress Session included speeches by Ralf Hemmingsen, Ulla Wewer, and Lene Juel Rasmussen and Keynote Addresses by four world renowned aging researchers: Povl Riis (The Age Forum), Bernard Jeune (University of Southern Denmark), George Martin (University of Washington, USA) and Jan Vijg (Albert Einstein School of Medicine, USA) as well as a lecture discussing the art-science interface by Thomas Söderqvist (Director, Medical Museion, University of Copenhagen). The topics of the first six Sessions of the Congress were: Neuroscience and DNA damage, Aging and Stress, Life Course, Environmental Factors and Neuroscience, Muscle and Life Span and Life Span and Mechanisms. Two additional Sessions highlighted ongoing research in the recently established Center for Healthy Aging at the University of Copenhagen. This report highlights outcomes of recent research on aging-related topics, as described at the IARU Congress on Aging, Longevity and Health. Copyright © 2011. Published by Elsevier Ireland Ltd.. All rights reserved.

  7. New Manning System Field Evaluation

    DTIC Science & Technology

    1986-03-01

    tckovics Un,!,d LTC Larry H. tng.anam, Ph.D. zust n - Farts R. Ki~rk.land, Ph.0. CharLene S. Lewis, Ph.D. David H. MarLowe, h.D ByDlstribuatoflf LTC James...parcticipacing agencies) wich an updaCe of WTAZ&’s current HMS research accivicies; (Z) Co raise Issues chac varranc, discassson among Che agencies...provides a summacy of che uniCs Chac have compLeced Che first LcecaCIon of ch•e Soldier VILL quesctona~ve as weLil as projeccLons .or cthe second and

  8. Osteogenic and chondrogenic master genes expression is dependent on the Kir2.1 potassium channel through the bone morphogenetic protein pathway.

    PubMed

    Pini, Jonathan; Giuliano, Serena; Matonti, Julia; Simkin, Dina; Rouleau, Matthieu; Bendahhou, Saïd

    2018-05-29

    Andersen's syndrome is a rare disorder affecting muscle, heart, and bone, that is associated with mutations leading to a loss of function of the inwardly rectifying K + channel Kir2.1. While the Kir2.1 function can be anticipated in excitable cells by controlling the electrical activity, its role in non-excitable cells remains to be investigated. Using Andersen's syndrome induced Pluripotent Stem cells, we investigated the cellular and molecular events during the osteoblastic and chondrogenic differentiation that are affected by the loss of the Ik1 current. We show that loss of Kir2.1 channel function impairs both osteoblastic and chondrogenic processes through the down regulation master gene expression. This down regulation is due to an impairment of the bone morphogenetic proteins signaling pathway through de-phosphorylation of the Smad proteins. Restoring Kir2.1 channel function in Andersen's syndrome cells rescued master genes expression, and restored normal osteoblasts and chondrocytes behavior. Our results show that Kir2.1-mediated activity controls endochondral and intramembranous ossification signaling pathways. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  9. National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015-2016): Protocol for Design and Development.

    PubMed

    Lopes, Carla; Torres, Duarte; Oliveira, Andreia; Severo, Milton; Guiomar, Sofia; Alarcão, Violeta; Ramos, Elisabete; Rodrigues, Sara; Vilela, Sofia; Oliveira, Luísa; Mota, Jorge; Teixeira, Pedro J; Nicola, Paulo J; Soares, Simão; Andersen, Lene Frost

    2018-02-15

    programs on the improvement of nutritional status and risk assessment related to food hazards, and the enhancement of PA. The infrastructures and data driven from this Survey are a solid basis to the development of a future national surveillance system on diet, PA, and other health behaviors reproducible over time. ©Carla Lopes, Duarte Torres, Andreia Oliveira, Milton Severo, Sofia Guiomar, Violeta Alarcão, Elisabete Ramos, Sara Rodrigues, Sofia Vilela, Luísa Oliveira, Jorge Mota, Pedro J Teixeira, Paulo J Nicola, Simão Soares, Lene Frost Andersen, The IAN-AF Consortium. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 15.02.2018.

  10. CECOM Index of Technical Papers, International Wire and Cable Symposia,

    DTIC Science & Technology

    1982-10-18

    ROOS. J.SoL. SEVENT4 SYIPOS1U.Mv 1959 8AD-656295) 143 MEAS’JRF1i4T JF THE DEGIEE OF DISPERSION OF CARBON B3LACK IN POYETHY LENE USING A3 SORPTION OF...COMPOSITIONS (AGING, wAXES) BY: YURGENt W.J. PALINCHAK9 So STICKNEY, P.8. TENTH SYMPOSI’UM, 1961 (AD-656172) 218 WATER Ati SORPTION OF ELASTOMERS BY: BIRIGGS9...Fl %R CA3Lf oESIGN AND MANUFAC -3USCHMER G. 55b WATER VAPOR SORPTION OF POI.YETHYLENE: A DECISI -JSCHER, G. 975 CORRELATION BTWCEN LAeORATJRY TESTS

  11. Health care costs in the elderly in Germany: an analysis applying Andersen’s behavioral model of health care utilization

    PubMed Central

    2014-01-01

    Background To analyze the association of health care costs with predisposing, enabling, and need factors, as defined by Andersen’s behavioral model of health care utilization, in the German elderly population. Methods Using a cross-sectional design, cost data of 3,124 participants aged 57–84 years in the 8-year-follow-up of the ESTHER cohort study were analyzed. Health care utilization in a 3-month period was assessed retrospectively through an interview conducted by trained study physicians at respondents’ homes. Unit costs were applied to calculate health care costs from the societal perspective. Socio-demographic and health-related variables were categorized as predisposing, enabling, or need factors as defined by the Andersen model. Multimorbidity was measured by the Cumulative Illness Rating Scale for Geriatrics (CIRS-G). Mental health status was measured by the SF-12 mental component summary (MCS) score. Sector-specific costs were analyzed by means of multiple Tobit regression models. Results Mean total costs per respondent were 889 € for the 3-month period. The CIRS-G score and the SF-12 MCS score representing the need factor in the Andersen model were consistently associated with total, inpatient, outpatient and nursing costs. Among the predisposing factors, age was positively associated with outpatient costs, nursing costs, and total costs, and the BMI was associated with outpatient costs. Conclusions Multimorbidity and mental health status, both reflecting the need factor in the Andersen model, were the dominant predictors of health care costs. Predisposing and enabling factors had comparatively little impact on health care costs, possibly due to the characteristics of the German social health insurance system. Overall, the variables used in the Andersen model explained only little of the total variance in health care costs. PMID:24524754

  12. Aerobic fitness and metabolic health in children: A clinical validation of directly measured maximal oxygen consumption versus performance measures as markers of health.

    PubMed

    Aadland, Eivind; Kvalheim, Olav Martin; Rajalahti, Tarja; Skrede, Turid; Resaland, Geir Kåre

    2017-09-01

    High aerobic fitness is consistently associated with a favorable metabolic health profile in children. However, measurement of oxygen uptake, regarded as the gold standard for evaluating aerobic fitness, is often not feasible. Thus, the aim of the present study was to perform a clinical validation of three measures of aerobic fitness (peak oxygen consumption [VO 2peak ] and time to exhaustion [TTE] determined from a graded treadmill protocol to exhaustion, and the Andersen intermittent running test) with clustered metabolic health in 10-year-old children. We included 93 children (55 boys and 38 girls) from Norway during 2012-2013 in the study. Associations between aerobic fitness and three different composite metabolic health scores (including lipoprotein subgroup particle concentrations, triglyceride, glucose, systolic blood pressure, and waist-to-height ratio) were determined by regression analyses adjusting for sex. The relationships among the measures of aerobic fitness were r  = 0.78 for VO 2peak vs. TTE, r  = 0.63 for VO 2peak vs. the Andersen test, and r  = 0.67 for TTE vs. the Andersen test. The Andersen test showed the strongest associations across all markers of metabolic health ( r  = - 0.45 to - 0.31, p  < 0.002), followed by VO 2peak ( r  = - 0.35 to - 0.12, p  < 0.256), and TTE ( r  = - 0.28 to - 0.10, p  < 0.334). Our findings indicate that indirect measures of aerobic fitness do not stand back as markers of metabolic health status in children, compared to VO 2peak . This is of great importance as good field tests provide opportunities for measuring aerobic fitness in many settings where measuring VO 2peak are impossible.

  13. New species of Pseudosmittia Edwards, 1932 and new records of Allocladius Kieffer, 1913 (Diptera: Chironomidae, Orthocladiinae) from South America.

    PubMed

    Mauad, Melina; Siri, Augusto; Donato, Mariano

    2013-01-01

    Three new species of Pseudosmittia Edwards from the Neotropical region, P. satheri, P. larga and P. trapezoidea, are described and figured as males. Allocladiusfortispinatus (Edwards), A. globosus Andersen et al. and A. quadrus Andersen et al. are redescribed on the basis of new material and their geographical distribution updated. A phylogenetic analysis was performed in order to assess the phylogenetic relationships of the new species. As a result, the species P. sœtheri and P. larga are found to be sister species belonging to the angusta group. The species P. trapezoidea is the sister group of the clade ((P. propetropis (P. tropis--P. lamellata)) and belongs to the brevifurcata group sensu lato.

  14. Guide for studying and evaluating internal accounting controls. Oil and gas exploration, development and production

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1981-01-01

    One of the most important responsibilities of any company's management is to establish and maintain, via periodic evaluations, is adequate internal accounting controls. Arthur Andersen and Co. approaches this problem as it relates to the oil and gas industry by logically dividing the economic events that affect a given company into four groups of activity termed ''business cycles'': treasury, expenditure, conversion (exploration, development, and production), and revenue activities. Independent public accountants can evaluate a company's existing internal controls much more thoroughly by studying only one category of business transactions at a time. Arthur Andersen's guide to reviewing internal controls coversmore » each step of this ''transaction-flow'' method as applied to a typical oil and gas company.« less

  15. Monitoring airborne fungal spores in an experimental indoor environment to evaluate sampling methods and the effects of human activity on air sampling.

    PubMed Central

    Buttner, M P; Stetzenbach, L D

    1993-01-01

    Aerobiological monitoring was conducted in an experimental room to aid in the development of standardized sampling protocols for airborne microorganisms in the indoor environment. The objectives of this research were to evaluate the relative efficiencies of selected sampling methods for the retrieval of airborne fungal spores and to determine the effect of human activity on air sampling. Dry aerosols containing known concentrations of Penicillium chrysogenum spores were generated, and air samples were taken by using Andersen six-stage, Surface Air System, Burkard, and depositional samplers. The Andersen and Burkard samplers retrieved the highest numbers of spores compared with the measurement standard, an aerodynamic particle sizer located inside the room. Data from paired samplers demonstrated that the Andersen sampler had the highest levels of sensitivity and repeatability. With a carpet as the source of P. chrysogenum spores, the effects of human activity (walking or vacuuming near the sampling site) on air sampling were also examined. Air samples were taken under undisturbed conditions and after human activity in the room. Human activity resulted in retrieval of significantly higher concentrations of airborne spores. Surface sampling of the carpet revealed moderate to heavy contamination despite relatively low airborne counts. Therefore, in certain situations, air sampling without concomitant surface sampling may not adequately reflect the level of microbial contamination in indoor environments. PMID:8439150

  16. Factors affecting Japanese retirees' healthcare service utilisation in Malaysia: a qualitative study

    PubMed Central

    Kohno, Ayako; Nik Farid, Nik Daliana; Musa, Ghazali; Abdul Aziz, Norlaili; Nakayama, Takeo; Dahlui, Maznah

    2016-01-01

    Objective While living overseas in another culture, retirees need to adapt to a new environment but often this causes difficulties, particularly among those elderly who require healthcare services. This study examines factors affecting healthcare service utilisation among Japanese retirees in Malaysia. Design We conducted 6 focus group discussions with Japanese retirees and interviewed 8 relevant medical services providers in-depth. Guided by the Andersen Healthcare Utilisation Model, we managed and analysed the data, using QSR NVivo 10 software and the directed content analysis method. Setting We interviewed participants at Japan Clubs and their offices. Participants 30 Japanese retirees who live in Kuala Lumpur and Ipoh, and 8 medical services providers. Results We identified health beliefs, medical symptoms and health insurance as the 3 most important themes, respectively, representing the 3 dimensions within the Andersen Healthcare Utilisation Model. Additionally, language barriers, voluntary health repatriation to Japan and psychological support were unique themes that influence healthcare service utilisation among Japanese retirees. Conclusions The healthcare service utilisation among Japanese retirees in Malaysia could be partially explained by the Andersen Healthcare Utilisation Model, together with some factors that were unique findings to this study. Healthcare service utilisation among Japanese retirees in Malaysia could be improved by alleviating negative health beliefs through awareness programmes for Japanese retirees about the healthcare systems and cultural aspects of medical care in Malaysia. PMID:27006344

  17. Analytic studies of the hard dumbell fluid

    NASA Astrophysics Data System (ADS)

    Morriss, G. P.; Cummings, P. T.

    A closed form analytic theory for the structure of the hard dumbell fluid is introduced and evaluated. It is found to be comparable in accuracy to the reference interaction site approximation (RISA) of Chandler and Andersen.

  18. DefenseLink Special: Travels with Pace, June 2006

    Science.gov Websites

    here today to discuss regional security issues in this strategic nation that, with its 1.1 billion where we are on our moral compass." Story Pace Visits Guam to Assess Infrastructure ANDERSEN AIR

  19. 50. VIEW TO EAST; SOUTH END OF MBE BUILDING, FIRST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    50. VIEW TO EAST; SOUTH END OF MBE BUILDING, FIRST FLOOR; SAFE, DOOR OPEN ELECTRONIC FLASH INTERIOR ILLUMINATION (Andersen) - Los Angeles Union Passenger Terminal, Mail, Baggage, & Express Building, 800 North Alameda Street, Los Angeles, Los Angeles County, CA

  20. 52. VIEW TO EAST; SOUTH END OF MBE BUILDING, SECOND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    52. VIEW TO EAST; SOUTH END OF MBE BUILDING, SECOND FLOOR; HIGHLY ALTERED INTERIOR OFFICE SPACE, FORMERLY REGIONAL OFFICES OF REA (Andersen) - Los Angeles Union Passenger Terminal, Mail, Baggage, & Express Building, 800 North Alameda Street, Los Angeles, Los Angeles County, CA

  1. A Review of Physical Activity Levels during Elementary School Physical Education

    ERIC Educational Resources Information Center

    Fairclough, Stuart J.; Stratton, Gareth

    2006-01-01

    Regular physical activity participation throughout childhood provides benefits to physical (Malina, Bouchard, & Bar-Or, 2004), physiological (Andersen, Wedderkopp, Hansen, Cooper, & Froberg, 2003), and psychological health (Mutrie & Parfitt, 1998). In recognition of these benefits, guidelines have been published in the United States…

  2. Predictors of Adolescent Health Care Utilization

    ERIC Educational Resources Information Center

    Vingilis, Evelyn; Wade, Terrance; Seeley, Jane

    2007-01-01

    This study, using Andersen's health care utilization model, examined how predisposing characteristics, enabling resources, need, personal health practices, and psychological factors influence health care utilization using a nationally representative, longitudinal sample of Canadian adolescents. Second, this study examined whether this process…

  3. Four Sides to Every Story: Creating Effective Multimedia Business Simulations.

    ERIC Educational Resources Information Center

    Graham, William; Legere, Sylvie M.

    1998-01-01

    Discusses the goal-based design concepts used to build a CD-ROM-based course for senior executives at Andersen Consulting. Topics include quality management; continuous improvement; problem-centered learning; video storytelling; feedback; multimedia learning environments; course organization; and possible future applications. (Author/LRW)

  4. 47. VIEW TO WEST; SOUTH END OF MBE BUILDING, FIRST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    47. VIEW TO WEST; SOUTH END OF MBE BUILDING, FIRST FLOOR; FORMER PACKAGE HANDLING AREA ADJACENT TO FORMER PACIFIC ELECTRIC RAILWAY TERMINAL (Andersen) - Los Angeles Union Passenger Terminal, Mail, Baggage, & Express Building, 800 North Alameda Street, Los Angeles, Los Angeles County, CA

  5. Language Resources for Language Technology: Proceedings of the TELRI (Trans-European Language Resources Infrastructure) European Seminar (1st, Tihany, Hungary, September 15-16, 1995).

    ERIC Educational Resources Information Center

    Rettig, Heike, Ed.

    This proceedings contains papers from the first European seminar of the Trans-European Language Resources Infrastructure (TELRI) include: "Cooperation with Central and Eastern Europe in Language Engineering" (Poul Andersen); "Language Technology and Language Resources in China" (Feng Zhiwei); "Public Domain Generic Tools:…

  6. Lessons from the Nightingale.

    ERIC Educational Resources Information Center

    Rodriguez, Carlos Xavier

    1997-01-01

    Employs Hans Christian Andersen's fairy tale, "The Nightingale," and the many lessons within it to help music educators design learning experiences that foster the development of musical expression. Conveys that without musical expression students' music will be mechanical, not unique and meaningful. (CMK)

  7. Description of Lentistivalius philippinensis, a new species of flea (Siphonaptera, Pygiosyllomorpha, Stivaliidae), and new records of Ascodipterinae (Streblidae) on bats and other small mammals from Luzon, The Philippines.

    PubMed

    Hastriter, Michael W; Bush, Sarah E

    2013-01-01

    During May 2009 and July 2011, we collected 357 mammals and examined each for ectoparasites. Among the ectoparasites collected, a new species of flea was discovered. This new species, Lentistivalius philippinensis, is described from the male sex only. Two males were recovered from two specimens of the soricid Crocidura grayi Dobson in Municipality Maria Aurora, Aurora Province, Luzon, Philippines. Additional fleas included Thaumapsylla breviceps orientalis Smit, Thaumapsylla longiforceps Traub, and Ischnopsyllus indicus Jordan. Although the latter species is common in Japan and documented in Guam (as well as mainland Southeast Asia) also on Pipistrellus javanicus (Gray), Ischnopsyllus indicus represents a new record in the Philippine Islands. The ascodipterinae (Streblidae) Maabella stomalata and Ascodipteron speiserianum Muir collected from Rhinolophus inops K. Andersen and Rhinolophus subrufus K. Andersen, respectively, also represent new host records. A key to the species of the flea genus Lentistivalius Traub is provided.

  8. The discovery of long-term potentiation.

    PubMed

    Lømo, Terje

    2003-04-29

    This paper describes circumstances around the discovery of long-term potentiation (LTP). In 1966, I had just begun independent work for the degree of Dr medicinae (PhD) in Per Andersen's laboratory in Oslo after an eighteen-month apprenticeship with him. Studying the effects of activating the perforant path to dentate granule cells in the hippocampus of anaesthetized rabbits, I observed that brief trains of stimuli resulted in increased efficiency of transmission at the perforant path-granule cell synapses that could last for hours. In 1968, Tim Bliss came to Per Andersen's laboratory to learn about the hippocampus and field potential recording for studies of possible memory mechanisms. The two of us then followed up my preliminary results from 1966 and did the experiments that resulted in a paper that is now properly considered to be the basic reference for the discovery of LTP.

  9. The discovery of long-term potentiation.

    PubMed Central

    Lømo, Terje

    2003-01-01

    This paper describes circumstances around the discovery of long-term potentiation (LTP). In 1966, I had just begun independent work for the degree of Dr medicinae (PhD) in Per Andersen's laboratory in Oslo after an eighteen-month apprenticeship with him. Studying the effects of activating the perforant path to dentate granule cells in the hippocampus of anaesthetized rabbits, I observed that brief trains of stimuli resulted in increased efficiency of transmission at the perforant path-granule cell synapses that could last for hours. In 1968, Tim Bliss came to Per Andersen's laboratory to learn about the hippocampus and field potential recording for studies of possible memory mechanisms. The two of us then followed up my preliminary results from 1966 and did the experiments that resulted in a paper that is now properly considered to be the basic reference for the discovery of LTP. PMID:12740104

  10. Factors affecting Japanese retirees' healthcare service utilisation in Malaysia: a qualitative study.

    PubMed

    Kohno, Ayako; Nik Farid, Nik Daliana; Musa, Ghazali; Abdul Aziz, Norlaili; Nakayama, Takeo; Dahlui, Maznah

    2016-03-22

    While living overseas in another culture, retirees need to adapt to a new environment but often this causes difficulties, particularly among those elderly who require healthcare services. This study examines factors affecting healthcare service utilisation among Japanese retirees in Malaysia. We conducted 6 focus group discussions with Japanese retirees and interviewed 8 relevant medical services providers in-depth. Guided by the Andersen Healthcare Utilisation Model, we managed and analysed the data, using QSR NVivo 10 software and the directed content analysis method. We interviewed participants at Japan Clubs and their offices. 30 Japanese retirees who live in Kuala Lumpur and Ipoh, and 8 medical services providers. We identified health beliefs, medical symptoms and health insurance as the 3 most important themes, respectively, representing the 3 dimensions within the Andersen Healthcare Utilisation Model. Additionally, language barriers, voluntary health repatriation to Japan and psychological support were unique themes that influence healthcare service utilisation among Japanese retirees. The healthcare service utilisation among Japanese retirees in Malaysia could be partially explained by the Andersen Healthcare Utilisation Model, together with some factors that were unique findings to this study. Healthcare service utilisation among Japanese retirees in Malaysia could be improved by alleviating negative health beliefs through awareness programmes for Japanese retirees about the healthcare systems and cultural aspects of medical care in Malaysia. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  11. The KMAT: Benchmarking Knowledge Management.

    ERIC Educational Resources Information Center

    de Jager, Martha

    Provides an overview of knowledge management and benchmarking, including the benefits and methods of benchmarking (e.g., competitive, cooperative, collaborative, and internal benchmarking). Arthur Andersen's KMAT (Knowledge Management Assessment Tool) is described. The KMAT is a collaborative benchmarking tool, designed to help organizations make…

  12. EVALUATION OF BIOLOGICALLY BASED DOSE-RESPONSE MODELING FOR DEVELOPMENTAL TOXICITY: A WORKSHOP REPORT

    EPA Science Inventory

    Evaluation of biologically based dose-response modeling for developmental toxicity: a workshop report.

    Lau C, Andersen ME, Crawford-Brown DJ, Kavlock RJ, Kimmel CA, Knudsen TB, Muneoka K, Rogers JM, Setzer RW, Smith G, Tyl R.

    Reproductive Toxicology Division, NHEERL...

  13. Transformer Specification Language: A System for Generating Analyzers and Its Applications

    DTIC Science & Technology

    2011-01-01

    like to thank present and former colleagues in PL group, Evan Driscoll, Aditya Thakur, Matt Elder, Tushar Sharma , Prathmesh Prabhu, Tycho Andersen, Emma...Robert Cohn, Robert Muth, Harish Patil, Artur Klauser, Geoff Lowney, Steven Wallace, Vijay Janapa Reddi, and Kim Hazelwood. Pin: building customized

  14. Residential Group Care Quarterly. Volume 5, Number 3, Winter 2005

    ERIC Educational Resources Information Center

    Michael, Jennifer, Ed.

    2005-01-01

    This issue of "Residential Group Care Quarterly" contains the following articles: (1) "Promising Practices for Adequately Funding and Reimbursing Residential Services" (Lloyd Bullard); (2) "Closing the Gender Gap" (Erin Andersen); (3) "Residential Child Care: Guidelines for Physical Techniques, Crisis Prevention, and Management" (Kurk Lalemand);…

  15. Specific Reading Disability in Historically Famous Persons.

    ERIC Educational Resources Information Center

    Aaron, P. G.; And Others

    1988-01-01

    The possibility that four famous men--Thomas Alva Edison, Woodrow Wilson, Hans Christian Andersen, and Leonardo da Vinci--might have been reading disabled is considered by examining information concerning: (1) biographical records, (2) cognitive characteristics, (3) neuropsychological characteristics, and (4) biological characteristics. (Author/DB)

  16. RCT of a Psychological Intervention for Patients with Cancer: I. Mechanisms of Change

    ERIC Educational Resources Information Center

    Andersen, Barbara L.; Shelby, Rebecca A.; Golden-Kreutz, Deanna M.

    2007-01-01

    Little is known about the therapeutic processes contributing to efficacy of psychological interventions for patients with cancer. Data from a randomized clinical trial yielding robust biobehavioral and health effects (B. L. Andersen et al., 2004, 2007) were used to examine associations between process variables, treatment utilization, and…

  17. Training Success Stories.

    ERIC Educational Resources Information Center

    Overmeyer-Day, Leslie; Benson, George

    1996-01-01

    Offers case studies of best training practices in leading companies (AEtna, Andersen Worldwide, Boeing, Digital Equipment, Tektronix, Texas Instruments, Allstate, and Sprint), elected by the Benchmarking Forum of the American Society for Training and Development. The practices are technology based and performance oriented and herald common…

  18. Changes Come as Old Hiring Practices Go.

    ERIC Educational Resources Information Center

    Journal of Career Planning & Employment, 1995

    1995-01-01

    Assembles a number of short takes that describe how some human resource professionals have changed their operations to upgrade their bottom line. Includes: Deloitte & Touche, Andersen Consulting, Baxter Healthcare Corporation, Brown & Root, AT&T, Ford Motor Company, and The Monsanto Company. Provides advice and tips. (JBJ)

  19. Proteomic Analysis of Trauma-Induced Heterotopic Ossification Formation

    DTIC Science & Technology

    2014-10-01

    journal name, book title, editors(s), publisher, volume number, page number(s), date, DOI, PMID, and/or ISBN. (1) Lay Press: a. Arthur Nead...Blast Injured. September 24, 2014. http://www.newswise.com/articles/ . c. Amy Andersen . Possible New Treatment For Soft Tissue Bone Formation In

  20. Contextual Variability in Personality From Significant–Other Knowledge and Relational Selves

    PubMed Central

    Andersen, Susan M.; Tuskeviciute, Rugile; Przybylinski, Elizabeth; Ahn, Janet N.; Xu, Joy H.

    2016-01-01

    We argue that the self is intrinsically embedded in an interpersonal context such that it varies in IF–THEN terms, as the relational self. We have demonstrated that representations of the significant other and the relationship with that other are automatically activated by situational cues and that this activation affects both experienced and expressed aspects of the self and personality. Here, we expand on developments of the IF–THEN cognitive-affective framework of personality system (Mischel and Shoda, 1995), by extending it to the domain of interpersonal relationships at the dyadic level (Andersen and Chen, 2002). Going beyond Mischel’s early research (Mischel, 1968), our framework combines social cognition and learning theory with a learning-based psychodynamic approach, which provides the basis for extensive research on the social-cognitive process of transference and the relational self as it arises in everyday social interactions (Andersen and Cole, 1990), evidence from which contributes to a modern conceptualization of personality that emphasizes the centrality of the situation. PMID:26779051

  1. Uncovering factors affecting use of the emergency department for less urgent health problems in urban and rural areas.

    PubMed

    Hodgins, Marilyn J; Wuest, Judith

    2007-09-01

    People who access the emergency department for less urgent health problems have been described as inappropriate users of the health-care system.Yet little is known about the factors precipitating such use and how these differ based on location of the emergency department. In this descriptive-correlational study guided by Andersen's Model of Health Services Use, 1612 people who presented to an emergency department with a less urgent health problem were interviewed. Analysis revealed rural/urban differences in the characteristics of patients, nature of the problems, actions taken, and factors precipitating the visit. Despite its popularity, the predictive capabilities of Andersen's model were limited in explaining use of self-treatment or willingness to wait for treatment. The findings show that an emergency department's roles and functions vary according to its location. Such insights provide direction for developing services that respond to the needs of people with less urgent health problems that are cognizant of geographic location.

  2. Preparation and reactions of enantiomerically pure α-functionalized Grignard reagents.

    PubMed

    Rayner, Peter J; O'Brien, Peter; Horan, Richard A J

    2013-05-29

    A strategy for the generation of enantiomerically pure α-functionalized chiral Grignard reagents is presented. The approach involves the synthesis of α-alkoxy and α-amino sulfoxides in ≥99:1 dr and ≥99:1 er via asymmetric deprotonation (s-BuLi/chiral diamine) and trapping with Andersen's sulfinate (menthol derived). Subsequent sulfoxide → Mg exchange (room temperature, 1 min) and electrophilic trapping delivers a range of enantiomerically pure α-alkoxy and α-amino substituted products. Using this approach, either enantiomer of products can be accessed in 99:1 er from asymmetric deprotonation protocols without the use of (-)-sparteine as the chiral ligand. Two additional discoveries are noteworthy: (i) for the deprotonation and trapping with Andersen's sulfinate, there is a lack of stereospecificity at sulfur due to attack of a lithiated intermediate onto the α-alkoxy and α-amino sulfoxides as they form, and (ii) the α-alkoxy-substituted Grignard reagent is configurationally stable at room temperature for 30 min.

  3. Contextual Variability in Personality From Significant-Other Knowledge and Relational Selves.

    PubMed

    Andersen, Susan M; Tuskeviciute, Rugile; Przybylinski, Elizabeth; Ahn, Janet N; Xu, Joy H

    2015-01-01

    We argue that the self is intrinsically embedded in an interpersonal context such that it varies in IF-THEN terms, as the relational self. We have demonstrated that representations of the significant other and the relationship with that other are automatically activated by situational cues and that this activation affects both experienced and expressed aspects of the self and personality. Here, we expand on developments of the IF-THEN cognitive-affective framework of personality system (Mischel and Shoda, 1995), by extending it to the domain of interpersonal relationships at the dyadic level (Andersen and Chen, 2002). Going beyond Mischel's early research (Mischel, 1968), our framework combines social cognition and learning theory with a learning-based psychodynamic approach, which provides the basis for extensive research on the social-cognitive process of transference and the relational self as it arises in everyday social interactions (Andersen and Cole, 1990), evidence from which contributes to a modern conceptualization of personality that emphasizes the centrality of the situation.

  4. The Little Mermaid: an icon of woman's condition in patriarchy, and the human condition of castration.

    PubMed

    Tseëlon, E

    1995-10-01

    Hans Christian Andersen's story 'The Little Mermaid' is read as a creation myth and a metaphor for woman's condition in patriarchy, broadly conceptualised within a Lacanian framework. In the first part, the psychoanalytic concept of castration (broadly conceptualised as containing any existential severance which forms the basis for sexual difference and subjectivity) is utilised to argue that the myth is about a construction of (mostly female) subjectivity through a series of separations or splits: (1) birth, (2) growing up, (3) desire and (4) death. Birth and death are read as representing real separations. Growing up is read as structured around a symbolic castration of tongue and voice, while desire is read as structured around lack. In the second part the ideological implications of Disney's adaptation of the original for its symbolic status are explored. It is argued that by simplifying and externalising internal complex conflicts in the Andersen story, Disney's version reduces the myth to a fairy tale, and reproduces the ideology of romantic love.

  5. Effective Teaching in the Multi-Cultural Classroom.

    ERIC Educational Resources Information Center

    Gotch, Donna; Brydges, Michael

    Community college instructors and administrators need to understand teacher immediacy research and the role of immediacy in the multi-cultural classroom. Immediacy can be viewed as a combination of nonverbal behaviors used to accentuate a verbal message and reduce physical and psychological distance between interactants. Janis Andersen's research…

  6. A temporal stable isotopic (d18O, dD, d-excess) comparison in glacier meltwater streams, Taylor Valley, Antarctica

    USDA-ARS?s Scientific Manuscript database

    In this paper, we describe the importance of hyporheic dynamics within Andersen Creek and Von Guerard Stream, Taylor Valley, Antarctica, from the 2010-11 melt season using natural tracers. Water collection started at flow onset and continued, with weekly hyporheic zone sampling. The water d18O and d...

  7. Trafficking of Metastatic Breast Cancer Cells in Bone

    DTIC Science & Technology

    2006-08-01

    Goldwater Award. She graduated in 2004 and is currently a graduate student at the University of Pennsylvania. • Elizabeth Chislock, a senior...carcinoma cells. J Histochem Cytochem 2000;48:643^51. 12. Amhlaoibh RN,Hoegh-Andersen P, Bru « nnerN, et al. Measurement of tumor load and distribution

  8. Evaluation of Altered Stromal/Epithelial Tissue Arrangement of the c-Kit Messaging System in the Control of Breast Cancer

    DTIC Science & Technology

    2008-07-31

    Lipofectamine-mediated transfection of pcDNA3/c-Kit. Chemosensitivity to the c-Kit modulating drugs, imatinib and alpha - fetoprotein -derived peptide (AFPep), was...Cancer Res. 10:3528-3534. 7. Bennett JA, Mesfin FB, Andersen TT, Gierthy JF, and Jacobson HI. (2002). A peptide derived from α- fetoprotein prevents

  9. Baltic Linguistics.

    ERIC Educational Resources Information Center

    Magner, Thomas F., Ed.; Schmalstieg, William R., Ed.

    The 20 papers in this collection are: "The Dative of Subordination in Baltic and Slavic"--H. Andersen; "The Vocalic Phonemes of the Old Prussian Elbing Vocabulary"--M.L. Burwell; "The Nominative Plural and Preterit Singular of the Active Participles in Baltic"--W. Cowgill; "The State of Linguistics in Soviet…

  10. Insect Flight: Computation and Biomimetic Design

    DTIC Science & Technology

    2008-05-31

    Mechanics, 37, 183-210 (2005). • Z. Jane Wang, ”Insect Flight”, McGraw Hill Year Book of Science and Technology, 2006. • Anders Andersen, Umberto Pesavento ...Umberto Pesavento , and Z. Jane Wang, ’Analysis of transitions between fluttering, tumbling and steady descent of falling cards’, Journal of Fluid

  11. The Utilization of Community Mental Health Services by the Hispanic Elderly.

    ERIC Educational Resources Information Center

    Starrett,Richard A.; And Others

    Multiple regression and path analyses of 29 demographic, social, and psychological variables were carried out to determine those variables that influenced the use of community-based mental health services by the Hispanic elderly. The variables were classified using the Andersen and Newman framework which conceptualizes the individual's demand for…

  12. What We Gain by Combining Variationist and Concept-Oriented Approaches: The Case of Acquiring Spanish Future-Time Expression

    ERIC Educational Resources Information Center

    Kanwit, Matthew

    2017-01-01

    This study aimed to advance research on first and second language future-time expression in Spanish and to demonstrate the strengths of combining functionalist, concept-oriented approaches (e.g., Andersen, 1984; Bardovi-Harlig, 2000; Shirai, 1995; von Stutterheim & Klein, 1987) with variationist approaches. The study targeted 140 participants…

  13. Systems of meaning and transference: Implicit significant-other activation evokes shared reality.

    PubMed

    Przybylinski, Elizabeth; Andersen, Susan M

    2015-10-01

    Evidence shows that representations of significant others (SOs) are used in interpersonal relations-for example, in the social-cognitive process of transference (see Andersen & Chen, 2002), a process that is assumed to serve meaning-making functions (Glassman & Andersen, 1999b). Five studies tested the more specific notion that implicit activation of an SO representation in transference should indirectly activate the worldview shared with the SO, leading to its active pursuit, validation, and protection. Shared worldviews were assessed beforehand, both idiographically, as values (Studies 1 and 4), and nomothetically, as political ideology or religious beliefs (Studies 2, 3, and 5). In each experiment, participants learned about new persons, one subtly resembling their own SO. Transference was assessed (memory bias; positive evaluation; see Andersen, Reznik, & Manzella, 1996) and, crucially, as predicted, when considering the new person resembling their SO (vs. the control persons), participants showed faster response latencies in a lexical decision task to words reflecting the worldview shared with the SO (vs. held only personally, Studies 1-3, or only by the SO, Study 3). With this person, they also anticipated a more meaningful interaction and actively socially tuned to the SO-shared worldview, selecting conversation topics reflecting the SO-shared worldview (vs. personally held or SO-held topics, Studies 1-3). Finally, threatening the SO-shared worldview with this person (vs. threatening personally held, SO-held, or irrelevant worldviews) prompted goal activation to restore the disrupted meaning (Studies 4 and 5), assessed by response latency in a lexical decision task. Transference thus evokes shared meaning systems and serves epistemic functions. (c) 2015 APA, all rights reserved).

  14. Can the Medical-nursing Combined Care Promote the Accessibility of Health Services for the Elderly in Nursing Home? A Study Protocol of Analysis of the Effectiveness Regarding Health Service Utilization, Health Status and Satisfaction with Care

    PubMed Central

    Bao, J; Wang, X-J; Yang, Y; Dong, R-Q; Mao, Z-F

    2015-01-01

    ABSTRACT Background: Currently, segmentation of healthcare and daily care for the elderly living in nursing homes usually results in the elderly not getting medical treatment timely and effectively. The medical-nursing combined care, which has been put into practice in several areas in China, is developed to enhance the accessibility of healthcare for the elderly. The aim of the study is to explore the effectiveness of the new care service, based on Andersen model, regarding health service utilization, health status and service satisfaction. Methods: The effectiveness of medical-nursing combined care will be measured in a cross-sectional study in nine nursing homes in Jianghan District, Wuhan, China, with 1067 old residents expected to participate. The questionnaire containing items of demographics, health service use, service satisfaction and instrument of SF-36 V2 is developed based on the conceptual framework of Andersen behaviour model of health service utilization. Descriptive analysis, variance analysis, multiple factors analysis, and correlation analysis will be performed to compare the sociological characteristics, health service use, health status and service satisfaction of the elderly living in different modes of nursing homes, to explore the influence factors of care effectiveness, as well as to study the relationship between health behaviour and health outcomes. Conclusion: The study design of analysing the effects of medical-nursing combined care and performing the horizontal comparison among the nursing homes under the framework of Andersen model is blazing new trails. Recruitment and design of questionnaire are important issues. Successful data collection and quality control are also necessary. Taking these into account, this study is estimated to provide evidence for the effectiveness of medical-nursing combined care service in China. PMID:27398940

  15. Can the Medical-nursing Combined Care Promote the Accessibility of Health Services for the Elderly in Nursing Home? A Study Protocol of Analysis of the Effectiveness Regarding Health Service Utilization, Health Status and Satisfaction with Care.

    PubMed

    Bao, J; Wang, X-J; Yang, Y; Dong, R-Q; Mao, Z-F

    2015-12-01

    Currently, segmentation of healthcare and daily care for the elderly living in nursing homes usually results in the elderly not getting medical treatment timely and effectively. The medical-nursing combined care, which has been put into practice in several areas in China, is developed to enhance the accessibility of healthcare for the elderly. The aim of the study is to explore the effectiveness of the new care service, based on Andersen model, regarding health service utilization, health status and service satisfaction. The effectiveness of medical-nursing combined care will be measured in a cross-sectional study in nine nursing homes in Jianghan District, Wuhan, China, with 1067 old residents expected to participate. The questionnaire containing items of demographics, health service use, service satisfaction and instrument of SF-36 V2 is developed based on the conceptual framework of Andersen behaviour model of health service utilization. Descriptive analysis, variance analysis, multiple factors analysis, and correlation analysis will be performed to compare the sociological characteristics, health service use, health status and service satisfaction of the elderly living in different modes of nursing homes, to explore the influence factors of care effectiveness, as well as to study the relationship between health behaviour and health outcomes. The study design of analysing the effects of medical-nursing combined care and performing the horizontal comparison among the nursing homes under the framework of Andersen model is blazing new trails. Recruitment and design of questionnaire are important issues. Successful data collection and quality control are also necessary. Taking these into account, this study is estimated to provide evidence for the effectiveness of medical-nursing combined care service in China.

  16. A self-consistent treatment of a fluid in an external potential

    NASA Astrophysics Data System (ADS)

    Boudh-Hir, M.-E.

    A simple fluid of particles near a repulsive structureless wall can be approximated by an identical fluid interacting with an ideal wall. The expansion in powers of the Andersen-Weeks-Chandler (AWC) blip function is used. Lado's criterion, which permits a self-consistent approximation, is extended to the surface case.

  17. Wielding the Military Shield and the Civilian Sword: Norwegian Civil-Military Interagency Cooperation in Afghanistan

    DTIC Science & Technology

    2010-06-11

    and Mads A. Andersen, “SV: Vi boer sette dato for uttrekning fra Afghanistan” [SV: We should set a date for pulling out of Afghanistan], Verdens Gang......Norwegian context, the research had to be based on other sources. The obvious solution to the problem was to interview professionals with practical

  18. Tense-Aspect Processing in Second Language Learners

    ERIC Educational Resources Information Center

    Chan, Ho Leung

    2012-01-01

    This dissertation provides a language processing perspective on the study of second language acquisition (SLA) of tense and aspect. Of special interest are the universal vis-a-vis language-specific dimensions of temporal and aspectual semantics involved. According to the Aspect Hypothesis (AH, e.g. Andersen & Shirai, 1994), the initial…

  19. Intensive Care

    ERIC Educational Resources Information Center

    Edmunds, Lavinia

    2004-01-01

    This article describes how two Baltimore teachers, Rachel Rosenblatt and Linda Andersen, provide tutorial work with hospital patients at the Kennedy Krieger Institute. Their work is part of the in-hospital educational aid offered by Baltimore school district to help students recover from serious illnesses or injuries. The Baltimore program, which…

  20. Well-Being in the Welfare State: The Redistributive Capacity of Education

    ERIC Educational Resources Information Center

    Jongbloed, Janine; Pullman, Ashley

    2016-01-01

    Focusing on the macro-micro interaction between institutional arrangements and individual life outcomes, this article investigates how welfare régime types impact the association between education and well-being, as measured by satisfaction with life. Theorising with Esping-Andersen's ideal-typical welfare régime typology, we hypothesise that…

  1. A Framework for School Change--The School Portfolio.

    ERIC Educational Resources Information Center

    Bernhardt, Victoria L.

    The "Education for the Future Initiative" is a national, privately-funded program initially sponsored by the Telesis Foundation and recently joined by Arthur Andersen & Co. to help schools undertake continuous improvement. The Initiative has pioneered a framework for school improvement in the form of a school portfolio. This document offers a…

  2. CEO-MD ties focus for future.

    PubMed

    1991-09-01

    Now more than ever, hospitals and physicians must work closely if both are to succeed in the future. This is just one conclusion, if not the most important one, of a recently released study by the American College of Healthcare Executives and Arthur Andersen and Co., reviewed in this issue.

  3. Publication Ratings versus Peer Ratings of Universities

    ERIC Educational Resources Information Center

    Anderson, Richard C.; And Others

    1978-01-01

    A quantitative comparison of peer versus bibliometric procedures for rating the quality of U.S. universities is presented. The quality of graduate faculty is measured by the Roose-Andersen peer rating, while bibliometric ratings are based on the number, average "quality," and total influence of university papers in each field.…

  4. Steps along a Continuum of Word Knowledge: Later Lexical Development through the Lens of Receptive Judgments

    ERIC Educational Resources Information Center

    Ameel, Eef; Malt, Barbara C.; Storms, Gert

    2014-01-01

    Usage patterns for common nouns continue to change well past the early years of language acquisition in free naming (Andersen, 1975; Ameel, Malt, & Storms, 2008). The current research evaluates whether this continued evolution is shown in receptive judgments as well, given their differing cognitive demands. We found an extended learning…

  5. Home Health Care Utilization: A Review of the Research for Social Work

    ERIC Educational Resources Information Center

    Kadushin, Goldie

    2004-01-01

    The author reviewed the literature to identify the variables associated with home health care utilization using the Andersen-Newman model as a framework for analysis. Sixty-four studies published between 1985 and 2000 were identified through PUBMED, Sociofile, and PsycINFO databases. Home health care was defined as in-home skilled nursing,…

  6. Racial/Ethnic Differences in the Relationship between the Use of Health Care Services and Functional Disability: The Health and Retirement Study (1992-2004)

    ERIC Educational Resources Information Center

    Bowen, Mary Elizabeth; Gonzalez, Hector M.

    2008-01-01

    Purpose: The purpose of this study was to examine racial/ethnic differences in the relationship between functional disability and the use of health care services in a nationally representative sample of older adults by using the Andersen behavioral model of health services utilization. Design and Methods: The study used 12 years of longitudinal…

  7. The Primary Care Physician and Cancer Literacy: Reducing Health Disparities in an Immigrant Population

    ERIC Educational Resources Information Center

    Lee, Hee Yun; Choi, Jeong-Kyun; Park, Ji Hye

    2014-01-01

    Objective: To evaluate the level of cancer literacy among Korean American immigrants and to identify the most influential predictors of cancer literacy in this population. Method: Using a quota-sampling strategy, 407 Korean American immigrants were recruited in the New York metropolitan area. The study was theoretically guided by the Andersen's…

  8. Mongolian Folktales.

    ERIC Educational Resources Information Center

    Stuart, Kevin C., Comp.; Grimme, Holger K., Ed.

    What Hans Christian Andersen and the Grimm brothers achieved by collecting stories from the common people that had been handed down orally from generation to generation is also achieved in this collection of folktales consisting of 45 fables and 65 tales and short stories. This publication, addressed to educators, anthropologists, and specialists…

  9. Evaluation Services from Needs Assessment to Follow-up: A Case Study.

    ERIC Educational Resources Information Center

    Broadbooks, Wendy J.

    This paper describes the nature and scope of evaluation services provided within the training division of Arthur Andersen & Company, and highlights some of the evaluation results. The cycle of assessment began with a needs assessment study at the curriculum level. Curriculum planning was undertaken for first-year trainees in the Tax Division.…

  10. Evaluating a Practice-Oriented Service Model to Increase the Use of Respite Services among Minorities and Rural Caregivers

    ERIC Educational Resources Information Center

    Montoro-Rodriguez, Julian; Kosloski, Karl; Montgomery, Rhonda J. V.

    2003-01-01

    Purpose: The goal of this study was to evaluate the practice-oriented model of service use (Yeatts, Crow, & Folts, 1992) relative to the more widely used behavioral model (Andersen, 1968) in its ability to explain the use of respite services by caregivers of Alzheimer's patients. Unlike the behavioral model, which focuses primarily on…

  11. Computerized and Networked Government Information Column

    ERIC Educational Resources Information Center

    Stratford, Juri

    2004-01-01

    The efforts of the U.S. federal government to develop E-Government services have been the subject of many recent news stories. In February 2002, Arthur Andersen's Office of Government Services released a usability analysis of federal government Web sites. In addition, in February, Vice-President Cheney announced the release of a report detailing…

  12. The Acquisition of Progressive and Resultative Meanings of the Imperfective Aspect Marker by L2 Learners of Japanese: Transfer, Universals, or Multiple Factors?

    ERIC Educational Resources Information Center

    Sugaya, Natsue; Shirai, Yasuhiro

    2007-01-01

    It has been observed that there is a strong association between the inherent (lexical) aspect of verbs and the acquisition of tense-aspect morphology (the aspect hypothesis; Andersen & Shirai, 1994). To investigate why such an association is observed, this study examined the influence of inherent aspect and learners' first language (L1) on the…

  13. A Computer Program for Solving a Set of Conditional Maximum Likelihood Equations Arising in the Rasch Model for Questionnaires.

    ERIC Educational Resources Information Center

    Andersen, Erling B.

    A computer program for solving the conditional likelihood equations arising in the Rasch model for questionnaires is described. The estimation method and the computational problems involved are described in a previous research report by Andersen, but a summary of those results are given in two sections of this paper. A working example is also…

  14. Free Radicals Accelerate the Decay of Long-Term Potentiation in Field CA1 of Guinea-Pig Hippocampus

    DTIC Science & Technology

    1991-01-01

    Andersen P. Sundberg S II . Sveen 0. Swann J W and Wigstrom II ( 1980 ) Possible mechanisms for long-lasting potentiation of synaptic transmission in...concentratin of gunea ptg heart Cardiotux Res. 23. 767-773 15 Hyslop P. A,* Hinshawv D B , Schrnufttatter 1,. . Sklar L A, Spragg R G soid Cochrane C G3

  15. Likelihood Ratio Tests for Special Rasch Models

    ERIC Educational Resources Information Center

    Hessen, David J.

    2010-01-01

    In this article, a general class of special Rasch models for dichotomous item scores is considered. Although Andersen's likelihood ratio test can be used to test whether a Rasch model fits to the data, the test does not differentiate between special Rasch models. Therefore, in this article, new likelihood ratio tests are proposed for testing…

  16. The Green and Burning Tree: On the Writing and Enjoyment of Children's Books.

    ERIC Educational Resources Information Center

    Cameron, Eleanor

    This collection of 12 critical essays--written for teachers, librarians, students, and parents--comments on the style, characterization, sense of wonder, and sense of reality in children's books. Specific subjects covered are (1) the fantasy worlds of Andersen, Beatrix Potter, Walter de la Mare, C. S. Lewis, Lewis Carroll, and J. R. R. Tolkien;…

  17. The Rural-Urban Divide: Health Services Utilization among Older Mexicans in Mexico

    ERIC Educational Resources Information Center

    Salinas, Jennifer J.; Al Snih, Soham; Markides, Kyriakos; Ray, Laura A.; Angel, Ronald J.

    2010-01-01

    Context: Mexico. Purpose: Using the health care service utilization model as a framework, this paper will analyze the differences in health care service use among older Mexicans living in urban and rural areas in Mexico. Methods: The Mexican Health and Aging Survey (MHAS) data were used to test the applicability of Andersen's "model of health…

  18. Will Graduating Year Accountancy Students Cheat in Examination? A Malaysian Case

    ERIC Educational Resources Information Center

    Abu Bakar, Nur Barizah; Ismail, Suhaiza; Mamat, Suaniza

    2010-01-01

    Due to a series of high profile accounting scandals and corporate collapses such as Enron, World.Com and Andersen, ethical conduct has been widely recognized as a crucial element in accounting profession and education. The growing concern over the ethics of professionals has also called for more academic research into this critical area. Our study…

  19. Welfare Attitudes and Social Expenditure: Do Regimes Shape Public Opinion?

    ERIC Educational Resources Information Center

    Jakobsen, Tor Georg

    2011-01-01

    This article examines the link between regime types, social expenditure, and welfare attitudes. By employing data on 19 countries taken from the World Values Survey, the main aim is to see to what degree the institutions of a country affect the attitudes of its citizens. According to Esping-Andersen ("The three worlds of welfare…

  20. Simulation of the toxicokinetics of trichloroethylene, methylene chloride, styrene and n-hexane by a toxicokinetics/toxicodynamics model using experimental data.

    PubMed

    Nakayama, Yumiko; Kishida, Fumio; Nakatsuka, Iwao; Matsuo, Masatoshi

    2005-01-01

    The toxicokinetics/toxicodynamics (TKTD) model simulates the toxicokinetics of a chemical based on physiological data such as blood flow, tissue partition coefficients and metabolism. In this study, Andersen and Clewell's TKTD model was used with seven compartments and ten differential equations for calculating chemical balances in the compartments (Andersen and Clewell 1996, Workshop on physiologically-based pharmacokinetic/pharmacodynamic modeling and risk assessment, Aug. 5-16 at Colorado State University, U.S.A) . Using this model, the authors attempted to simulate the behavior of four chemicals: trichloroethylene, methylene chloride, styrene and n-hexane, and the results were evaluated. Simulations of the behavior of trichloroethylene taken in via inhalation and oral exposure routes were also done. The differences between simulations and measurements are due to the differences between the absorption rates of the exposure routes. By changing the absorption rates, the simulation showed agreement with the measured values. The simulations of the other three chemicals showed good results. Thus, this model is useful for simulating the behavior of chemicals for preliminary toxicity assessment.

  1. Examining Sexual Orientation Disparities in Unmet Medical Needs among Men and Women.

    PubMed

    Everett, Bethany G; Mollborn, Stefanie

    2014-08-01

    Using the National Longitudinal Study of Adolescent Health (N = 13,810), this study examines disparities in unmet medical needs by sexual orientation identity during young adulthood. We use binary logistic regression and expand Andersen's health care utilization framework to identify factors that shape disparities in unmet medical needs by sexual orientation. We also investigate whether the well-established gender disparity in health-seeking behaviors among heterosexual persons holds for sexual minorities. The results show that sexual minority women are more likely to report unmet medical needs than heterosexual women, but no differences are found between sexual minority and heterosexual men. Moreover, we find a reversal in the gender disparity between heterosexual and sexual minority populations: heterosexual women are less likely to report unmet medical needs than heterosexual men, whereas sexual minority women are more likely to report unmet medical needs compared to sexual minority men. Finally, this work advances Andersen's model by articulating the importance of including social psychological factors for reducing disparities in unmet medical needs by sexual orientation for women.

  2. Blind Flight? A New Troglobiotic Orthoclad (Diptera, Chironomidae) from the Lukina Jama - Trojama Cave in Croatia.

    PubMed

    Andersen, Trond; Baranov, Viktor; Hagenlund, Linn Katrine; Ivković, Marija; Kvifte, Gunnar Mikalsen; Pavlek, Martina

    2016-01-01

    The genus Troglocladius Andersen, Baranov et Hagenlund, gen. n. is erected based on T. hajdi Andersen, Baranov et Hagenlund, sp. n. collected at 980 m depth in the Lukina jama-Trojama cave system in Croatia. Morphological features such as pale color, strongly reduced eyes and very long legs make it a typical cave animal. Surprisingly, it has also retained large wings and appears to be capable of flight which would make T. hajdi the first flying troglobiont worldwide, disproving previous beliefs that bats are the only animals capable of flying in complete darkness. Morphologically the new species does not readily fit within any described genus, but shares characteristics with genera both in the tribes "Metriocnemini" and "Orthocladiini". Bayesian molecular phylogenetic analysis using the markers COI, 18S rDNAs, 28S rDNA, CADI, and CADIV groups it with the genera Tvetenia, Cardiocladius and Eukiefferiella in the tribe "Metriocnemini". Troglocladius hajdi may be parthenogenetic, as only females were collected. The discovery confirms the position of the Dinaric arch as a highly important hotspot of subterranean biodiversity.

  3. Blind Flight? A New Troglobiotic Orthoclad (Diptera, Chironomidae) from the Lukina Jama – Trojama Cave in Croatia

    PubMed Central

    Ivković, Marija; Kvifte, Gunnar Mikalsen; Pavlek, Martina

    2016-01-01

    The genus Troglocladius Andersen, Baranov et Hagenlund, gen. n. is erected based on T. hajdi Andersen, Baranov et Hagenlund, sp. n. collected at 980 m depth in the Lukina jama—Trojama cave system in Croatia. Morphological features such as pale color, strongly reduced eyes and very long legs make it a typical cave animal. Surprisingly, it has also retained large wings and appears to be capable of flight which would make T. hajdi the first flying troglobiont worldwide, disproving previous beliefs that bats are the only animals capable of flying in complete darkness. Morphologically the new species does not readily fit within any described genus, but shares characteristics with genera both in the tribes “Metriocnemini” and “Orthocladiini”. Bayesian molecular phylogenetic analysis using the markers COI, 18S rDNAs, 28S rDNA, CADI, and CADIV groups it with the genera Tvetenia, Cardiocladius and Eukiefferiella in the tribe “Metriocnemini”. Troglocladius hajdi may be parthenogenetic, as only females were collected. The discovery confirms the position of the Dinaric arch as a highly important hotspot of subterranean biodiversity. PMID:27119557

  4. ESTCP Munitions Response Live Site Demonstrations, Andersen Air Force Base, Guam

    DTIC Science & Technology

    2016-04-01

    April 2016 Mr. Ryan Steigerwalt Weston Solutions , Inc. Distribution Statement A ESTCP MUNITIONS RESPONSE LIVE SITE...Steigerwalt Weston Solutions , Inc. Version 2 REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden for this...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Weston Solutions 1400 Weston Way West Chester, PA 19380

  5. Quality of Life in Rural and Urban Adults 65 Years and Older: Findings from the National Health and Nutrition Examination Survey

    ERIC Educational Resources Information Center

    Baernholdt, Marianne; Yan, Guofen; Hinton, Ivora; Rose, Karen; Mattos, Meghan

    2012-01-01

    Purpose: The proportion of people over 65 years of age is higher in rural areas than in urban areas, and their numbers are expected to increase in the next decade. This study used Andersen's behavioral model to examine quality of life (QOL) in a nationally representative sample of community-dwelling adults 65 years and older according to…

  6. Personnel

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2006-10-13

    Le président du conseil M.Doran explique la décision que le conseil du Cern vient de prendre sur la 4.étape du régime complémentaire des pensions. Le président du comité des finances le Dr.Andersen ainsi que le Prof.Connor(?) prennent aussi la parole

  7. Leap of Faith: An Interview with Max Velthuijs

    ERIC Educational Resources Information Center

    de Rijke, Victoria; Hollands, Howard

    2006-01-01

    The now late great Max Velthuijs was filmed in April 2004 discussing his work with Victoria de Rijke and Howard Hollands, who began the interview expecting Max to be working under certain artistic and cultural influences, none of which seemed to be the case! Max describes what brought him home to Andersen Press, the freedom of children's…

  8. PESA and Me

    ERIC Educational Resources Information Center

    Harris, Kevin

    2009-01-01

    In this article, the author shares his experience as a lecturer in Anna Hogg's Department at Sydney Teachers College, where he became involved at the very beginning of Bill Andersen's and Anna's (and Les Brown's) efforts to form what was to become Philosophy of Education Society of Australasia (PESA). The author provides a brief overview of PESA…

  9. PHARMACOKINETICS OF N-BUTYL ACETATE AND ITS METABOLITES IN MALE SPRAGUE DAWLEY RATS AFTER INTRAVENOUS ADMINISTRATION

    EPA Science Inventory

    FAMILY APPROACH PBPK MODELING OF N-BUTYL ACETATE AND ITS METABOLITES IN MALE RATS
    P.J. Deisinger1, J.G. Teeguarden2, H.A. Barton3, J.C. English1, W.D. Faber4, T.R. Tyler5, M.I. Banton6, M.E. Andersen7. 1Health & Environ. Laboratories., Eastman Kodak Company, Rochester, NY, USA...

  10. The Utilization of Social Services by the Mexican-American Elderly.

    ERIC Educational Resources Information Center

    Starrett, Richard A.; Decker, James T.

    The study tested the Andersen-Newman causal model of social service use as a means of determining patterns for social service use by Mexican American elderly. The model was shown to have applicability for identifying common and unique determinants of service use. Thirty-seven variables and data from a 1979-80 15-state survey were selected to form…

  11. Personnel

    ScienceCinema

    None

    2017-12-09

    Le président du conseil M.Doran explique la décision que le conseil du Cern vient de prendre sur la 4.étape du régime complémentaire des pensions. Le président du comité des finances le Dr.Andersen ainsi que le Prof.Connor(?) prennent aussi la parole

  12. Virtual Representation of IID Observations in Bayesian Belief Networks

    DTIC Science & Technology

    1994-04-01

    programs for structuring and using Bayesian inference include ERGO ( Noetic Systems, Inc., 1991) and HUGIN (Andersen, Jensen, Olesen, & Jensen, 1989...Nichols, S.. Chipman, & R. Brennan (Eds.), Cognitively diagnostic assessment. Hillsdale, NJ: Erlbaum. Noetic Systems, Inc. (1991). ERGO [computer...Dr Geore Eageiard Jr Chicago IL 60612 US Naval Academy Division of Educational Studies Annapolis MD 21402-5002 Emory University Dr Janice Gifford 210

  13. From Shakespeare to Star Trek and beyond: a Medline search for literary and other allusions in biomedical titles.

    PubMed

    Goodman, Neville W

    2005-12-24

    To document biomedical paper titles containing literary and other allusions. Retrospective survey. Medline (1951 to mid-2005) through Dialog Datastar. Allusions to Shakespeare, Hans Christian Andersen, proverbs, the Bible, Lewis Carroll, and movie titles, corrected and scaled for five year periods 1950-4 to 2000-4. More than 1400 Shakespearean allusions exist, a third of them to "What's in a name" and another third to Hamlet-mostly to "To be or not to be." The trend of increasing use of allusive titles, identified from Shakespeare and Andersen, is paralleled by allusions to Carroll and proverbs; the trend of biblical allusions is also upward but is more erratic. Trends for newer allusions are also upwards, including the previously surveyed "paradigm shift." Allusive titles are likely to be to editorial or comment rather than to original research. The similar trends are presumably a mark of a particular learnt author behaviour. Newer allusions may be becoming more popular than older ones. Allusive titles can be unhelpful to reviewers and researchers, and many are now clichés. Whether they attract readers or citations is unknown, but better ways of gaining attention exist.

  14. Bug Distribution and Pattern Classification.

    DTIC Science & Technology

    1985-07-15

    Center Educational Psychology University of Leyden San Diego. CA 92152 Urbana. IL 61801 Education Research Center oernaavelaan 2 Dr. Erling B. Andersen...Dr. Dattprasad rlivgi 23314 EN Leyden Department of Statistics Syracuse University The NETHERLANDS 3tudiestraede 6 Department of Psychology 1455...Rebecca Hetter Learning R&D Center Navy Personnel R&D Center University of Pittsburgh Ms. Kathleen Moreno Code 62 Pittsburgh, PA 15260 Navy Personnel R

  15. Publications - Plafker, George and Berg, H.C., 1994 | Alaska Division of

    Science.gov Websites

    , M.S., Smith, T.E., Berg, H.C., Andersen, G.L., Chipp, E.R., Gaard, D.R., Burton, P.J., Dunbler, John ., Newberry, R.J., Rogers, R.K., Rubin, C.M., Swainbank, R.C., Smith, P.R., and Stephens, Jackie, 1994 , H.C., Brew, D.A., Grybeck, Donald, Robinson, M.S., Smith, T.E., and Yeend, Warren, 1994, Metallogenic

  16. Bayesian Estimation in the One-Parameter Latent Trait Model.

    DTIC Science & Technology

    1980-03-01

    Journal of Mathematical and Statistical Psychology , 1973, 26, 31-44. (a) Andersen, E. B. A goodness of fit test for the Rasch model. Psychometrika, 1973, 28...technique for estimating latent trait mental test parameters. Educational and Psychological Measurement, 1976, 36, 705-715. Lindley, D. V. The...Lord, F. M. An analysis of verbal Scholastic Aptitude Test using Birnbaum’s three-parameter logistic model. Educational and Psychological

  17. Minutes of the Explosives Safety Seminar (25). Volume 4. Held in Anaheim, California on 18-20 Aug 1992

    DTIC Science & Technology

    1992-08-01

    reaction process ; - sensitivity versus damage (vivacity, specific surface, porosity, density variation). So, most of the experimental tests need to...the later mapping process would form a better basis for compliance with published requirementsi I than the current approach. Seytion Summary It takes... Processing of Explosives, Propellants and Ingredients, AIIPA, San Diego, (’alif. April 1991. 49. W.11I. Andersen and N.A. Louie, " Projectile Impact Ignition

  18. Human Behaviour in High Stress Situations in Aerospace Operations Conference Proceedings Held in The Hague, The Netherlands on 24-28 October 1988

    DTIC Science & Technology

    1989-06-01

    Continuously stimulating advances in the aerospace sciences relevant to strengthening the common defence posture; - Improving the co-operation among member...very stimulating symposium. vii KI-1 PREDICTION OF PERSONALITY Harald T. Andersen M.D., Ph.D., D.Sc,D.Av.Med. Director RNoAF Institute of Aviation...audio tape recorder which was connected to the aircraft communication system. This recorder provided a continuous auditory record of each mission so that

  19. Mitigating Distributed Denial of Service Attacks in an Anonymous Routing Environment: Client Puzzles and Tor

    DTIC Science & Technology

    2006-03-01

    Technologies: Workshop on Design Issues in Anonymity and Unobservability, 30–45. Springer-Verlag, LNCS 2009, July 2000. 10. Chaum , David . “Untraceable...electronic mail, return addresses, and digital pseudonyms”. Communications of the ACM, 4(2), February 1981. 11. Chaum , David . “The Dining Cryptographers...Proceedings of Eurocrypt, 294–311. 2003. 4. Andersen, David G. “Mayday: Distributed Filtering for Internet Services”. 4th Usenix Symposium on Internet

  20. Factors Related to Attrition from VA Healthcare Use: Findings from the National Survey of Women Veterans

    DTIC Science & Technology

    2013-01-01

    present analysis we draw on aspects of the Andersen Behavioral Model,21 particularly need characteristics (e.g., mental health), as determinants of...converted to number of years ago. Number of years since last VA use was grouped into five-year increments. Statistical Analysis The analytic sample was...healthcare several decades ago. A limitation of our study is that recollections about the decision to discontinue VA care are subject to recall bias

  1. A new invasive weed-feeding species of Polypedilum (Pentapedilum) Kieffer from South Africa (Diptera: Chironomidae, Chironominae).

    PubMed

    Andersen, Trond; González, Orestes C Bello; Baars, Jan-Robert; Earle, William

    2015-08-19

    Polypedilum (Pentapedilum) tuburcinatum Andersen et Bello González sp. n. is described and figured as male, female, pupa and larva based on material collected in the Eastern Cape Province in South Africa, imported into quarantine in Ireland and reared in the laboratory. The species feeds on the aquatic weed Lagarosiphon major (Ridl.) Moss ex Wager and is regarded as a promising candidate agent for biological control of this invasive weed.

  2. Evaluation of the Toxicokinetic Study of 1,2-Propanediol Dinitrate (PGDN) in the Dog.

    DTIC Science & Technology

    1982-05-01

    Values as high as 50% contributed to a delayed drug effect of increased heart rate. Urine production, presumably changed due to blood pressure...Andersen and Mehl (1973) compared the effects of acute doses of PGDN and triethylene glycol dinitrate in rats, mice and guinea pigs. Although both...death when exposure ceases. Additional metabolic effects of PGDN and similar compounds were noted by Komura (1974). Here, ethanol preference and

  3. Spouse READI (Resilience Education and Deployment Information): Randomized Clinical Trial. Formerly Reintegration: The Role of Spouse Telephone BATTLEMIND Randomized Clinical Trial

    DTIC Science & Technology

    2014-04-01

    families. Mil Behav Health 2013; 1(1): 22-30. 4 Aday, Lu Ann ; Andersen R. A framework for the study of access to medical care. Health Serv Res 1974...identifying and re -shaping negative and destructive thoughts), and support (Belle et al., 2006; Gottman, Gottman, & Atkins, 2011, Schulz et al...Research, Translation and Practice. University of Michigan Geriatrics Retreat, Human Research across the Translational Spectrum: From the Lab to the

  4. Facilitating Soldier Receipt of Needed Mental Health Treatment

    DTIC Science & Technology

    2013-11-01

    an intelligent lay audience can understand (Scientific American style ). In addition to the publications and presentations developed based on the...only thing was my parents , with like the 4 13 meds and stuff. Just that whole stigma. Discharge from Army ’Cause I did not want them to try to...predis- posing, enabling, and need factors (Andersen & Newman , 1973). Predisposing factors are pre- existing factors that contribute to an individu

  5. Flapping Wing Flight Dynamic Modeling

    DTIC Science & Technology

    2011-08-22

    cases. Pesavento and Wang [24] solved the two dimensional Navier-Stokes equations in relation to a piece of free falling paper at Reynolds number near...von Karman, T. and Burgers, J. M., Gerneral Aerodynamic Theory - Perfect Fluids , Vol. II, Julius Springer, Berlin, 1935. [24] Pesavento , U. and Wang...2004, pp. 14. [25] Andersen, A., Pesavento , U., and Wang, Z. J., Unsteady aerodynamics of uttering and tumbling plates, Journal of Fluid Mechanics

  6. DOT/FAA Human Factors Workshop on AVIATION. Transcript. Volume I.

    DTIC Science & Technology

    1980-11-01

    workshop and then will be published in their entirety. F S’ I-N-D-E-X AGENDA PAGE OPENING REMARKS James P . Andersen, Workshop Moderator Director of Air...and Marine Systems Transportation Systems Center Dr. James Costantino, Director Transportation Systems Center Langhorne Bond, Administrator Federal...conference, and it’s now my pleasure to introduce to you the Administrator of the Federal Aviation Administration, Langhorne Bond. MR. BOND: Thank you

  7. From Shakespeare to Star Trek and beyond: a Medline search for literary and other allusions in biomedical titles

    PubMed Central

    Goodman, Neville W

    2005-01-01

    Objectives To document biomedical paper titles containing literary and other allusions. Design Retrospective survey. Setting Medline (1951 to mid-2005) through Dialog Datastar. Main outcome measure Allusions to Shakespeare, Hans Christian Andersen, proverbs, the Bible, Lewis Carroll, and movie titles, corrected and scaled for five year periods 1950-4 to 2000-4. Results More than 1400 Shakespearean allusions exist, a third of them to “What's in a name” and another third to Hamlet—mostly to “To be or not to be.” The trend of increasing use of allusive titles, identified from Shakespeare and Andersen, is paralleled by allusions to Carroll and proverbs; the trend of biblical allusions is also upward but is more erratic. Trends for newer allusions are also upwards, including the previously surveyed “paradigm shift.” Allusive titles are likely to be to editorial or comment rather than to original research. Conclusions The similar trends are presumably a mark of a particular learnt author behaviour. Newer allusions may be becoming more popular than older ones. Allusive titles can be unhelpful to reviewers and researchers, and many are now clichés. Whether they attract readers or citations is unknown, but better ways of gaining attention exist. PMID:16373745

  8. Dissipative particle dynamics: Effects of thermostating schemes on nano-colloid electrophoresis

    NASA Astrophysics Data System (ADS)

    Hassanzadeh Afrouzi, Hamid; Moshfegh, Abouzar; Farhadi, Mousa; Sedighi, Kurosh

    2018-05-01

    A novel fully explicit approach using dissipative particle dynamics (DPD) method is introduced in the present study to model the electrophoretic transport of nano-colloids in an electrolyte solution. Slater type charge smearing function included in 3D Ewald summation method is employed to treat electrostatic interaction. Performance of various thermostats are challenged to control the system temperature and study the dynamic response of colloidal electrophoretic mobility under practical ranges of external electric field (0 . 072 < E < 0 . 361 v/nm) covering linear to non-linear response regime, and ionic salt concentration (0.049 < SC < 0 . 69 [M]) covering weak to strong Debye screening of the colloid. System temperature and electrophoretic mobility both show a direct and inverse relationships respectively with electric field and colloidal repulsion; although they each respectively behave direct and inverse trends with salt concentration under various thermostats. Nosé-Hoover-Lowe-Andersen and Lowe-Andersen thermostats are found to function more effectively under high electric fields (E > 0 . 145[v/nm ]) while thermal equilibrium is maintained. Reasonable agreements are achieved by benchmarking the system radial distribution function with available EW3D modellings, as well as comparing reduced mobility against conventional Smoluchowski and Hückel theories, and numerical solution of Poisson-Boltzmann equation.

  9. Barriers to mental health service use among distressed family caregivers of lung cancer patients.

    PubMed

    Mosher, C E; Given, B A; Ostroff, J S

    2015-01-01

    Although family caregivers of patients with lung and other cancers show high rates of psychological distress, they underuse mental health services. This qualitative study aimed to identify barriers to mental health service use among 21 distressed family caregivers of lung cancer patients. Caregivers had not received mental health services during the patient's initial months of care at a comprehensive cancer centre in New York City. Thematic analysis of interview data was framed by Andersen's model of health service use and Corrigan's stigma theory. Results of our analysis expand Andersen's model by providing a description of need variables (e.g. psychiatric symptoms), enabling factors (e.g. finances), and psychosocial factors associated with caregivers' non-use of mental health services. Regarding psychosocial factors, caregivers expressed negative perceptions of mental health professionals and a desire for independent management of emotional concerns. Additionally, caregivers perceived a conflict between mental health service use and the caregiving role (e.g. prioritising the patient's needs). Although caregivers denied stigma associated with service use, their anticipated negative self-perceptions if they were to use services suggest that stigma may have influenced their decision to not seek services. Findings suggest that interventions to improve caregivers' uptake of mental health services should address perceived barriers. © 2014 John Wiley & Sons Ltd.

  10. Physical Fitness Is Longitudinally Associated With Academic Performance During Childhood and Adolescence, and Waist Circumference Mediated the Relationship.

    PubMed

    Lima, Rodrigo Antunes; Larsen, Lisbeth Runge; Bugge, Anna; Andersen, Lars Bo

    2018-03-10

    The current investigation aimed to investigate the longitudinal association between physical fitness and academic performance over 3 years in adolescents. A secondary aim was to determine to what extent waist circumference mediated the association between physical fitness and academic performance. For the current study, 1020 students from first grade [mean age: 7.87 (0.34) y] to fifth grade [mean age: 11.87 (0.37) y] were monitored annually for 3 years (2010-2013). Physical fitness was assessed using the Andersen test, 5 × 5-m shuttle run, jump height, and grip strength tests and by constructing a composite score combining all 4 fitness tests. Academic performance was assessed by national standardized tests in Danish language and math. Generalized structural equation modeling was used to evaluate the relationships between these variables. The Andersen test (standardized β = 0.15 SD), shuttle run (β = -0.18 SD), jump height (β = 0.10 SD), and the fitness composite score (β = 0.23 SD) were positively associated with academic performance over 3 years. In addition, waist circumference partially mediated the association between physical fitness and academic performance. Thus, physical fitness abilities should be stimulated during childhood and early adolescence because of their positive association with academic performance.

  11. Identification of Two Candidate Tumor Suppressor Genes on Chromosome 17p13.3: Assessment of Their Roles in Breast and Ovarian Carcinogenesis

    DTIC Science & Technology

    2001-07-01

    USA. 86: 29. Mattheakis. L. C.. Sor. F.. and Collier . R. J. Diphthamide synthesis in Sacclharomnvces 5136-5140, 1989. cerevisiae: structure of the...Cell. Biochem. 138: 131-133. Vargas, M. P., Zhuang, Z., Wang, C., Vortmeyer, A., Linehan, W. M.. Mattheakis, H. C., Sor, F., and Collier , R. J. (1993...W. H., and Collier , R. J. (1992). DPH5, a Wilson, R., Ainscough, R., Andersen, K., Baynes, C., Berks, M., methyltransferase gene required for

  12. Development and Validation of Methods for Applying Pharmacokinetic Data in Risk Assessment. Volume 3. Tetrachloroethylene

    DTIC Science & Technology

    1990-12-01

    Armstrong Aerospace Medical Research Laboratory, Wright Paterson Air Force Base, and Drs. Melvin Andersen and Michael Cargas , formerly with the Harry G...based on the arterial blood concentration surrogate were more III-1-10 similar to those de ’!ved in the traditional manner than were the estimates based on...pharmacokinetic modeling. Prepared by Office of Risk Analysis, Oak Ridge National L-ioratory, Oak Pidge, Tenn.zsee. Prepared under Contract No. DE -ACO5-84

  13. Translations on Western Europe, Number 1063

    DTIC Science & Technology

    1977-05-05

    other. When the national committee of the Center Party had its big dinner at Ystad in June of last year, one of the speeches was given by the...build tall greenhouses of the span type . Arboriculture: The growing of citrus trees should be protected and attention should be paid to the...that was established by the United Nations . K.B. Andersen praised the Industrial Council for its recent initiative by means of a publication

  14. Probability-Based Inference in Cognitive Diagnosis

    DTIC Science & Technology

    1994-02-01

    of variables in the student model. In Siegler’s study , this corresponds to determining how a child with a given set of strategies at her disposal...programs are commercially available to carry out the number-crunching aspect. We used Andersen, Jensen, Olesen, and Jensen’s (1989) HUGIN program and Noetic ... studying how they are typically acquired (e.g., in mechanics, Clement, 1982; in ratio and proportional reasoning, Karplus, Pulos, & Stage, 1983), and

  15. Quantum mechanical reaction probability of triplet ketene at the multireference second-order perturbation level of theory.

    PubMed

    Ogihara, Yusuke; Yamamoto, Takeshi; Kato, Shigeki

    2010-09-23

    Triplet ketene exhibits a steplike structure in the experimentally observed dissociation rates, but its mechanism is still unknown despite many theoretical efforts in the past decades. In this paper we revisit this problem by quantum mechanically calculating the reaction probability with multireference-based electronic structure theory. Specifically, we first construct an analytical potential energy surface of triplet state by fitting it to about 6000 ab initio energies computed at the multireference second-order Mller-Plesset perturbation (MRMP2) level. We then evaluate the cumulative reaction probability by using the transition state wave packet method together with an adiabatically constrained Hamiltonian. The result shows that the imaginary barrier frequency on the triplet surface is 328i cm-1, which is close to the CCSD(T) result (321i cm-1) but is likely too large for reproducing the experimentally observed steps. Indeed, our calculated reaction probability exhibits no signature of steps, reflecting too strong tunneling effect along the reaction coordinate. Nevertheless, it is emphasized that the flatness of the potential profile in the transition-state region (which governs the degree of tunneling) depends strongly on the level of electronic structure calculation, thus leaving some possibility that the use of more accurate theories might lead to the observed steps. We also demonstrate that the triplet potential surface differs significantly between the CASSCF and MRMP2 results, particularly in the transition-state region. This fact seems to require more attention when studying the "nonadiabatic" scenario for the steps, in which the crossing seam between S0 and T1 surfaces is assumed to play a central role.

  16. Health care use amongst online buyers of medications and vitamins.

    PubMed

    Desai, Karishma; Chewning, Betty; Mott, David

    2015-01-01

    With increased use of the internet, more people access medications and health supplements online. However little is known about factors associated with using online buying. Given the variable quality of online pharmacies, an important question is whether online consumers also have health care providers with whom they discuss internet information and decisions. To help address these gaps this study used the Andersen Model to explore (1) the characteristics of internet buyers of medicines and/vitamins, (2) the association between health care use and buying medicines and/vitamins online drawing on the Andersen health care utilization framework, and (3) factors predicting discussion of internet information with health providers. The National Cancer Institute's Health Information National Trends Survey (HINTS) 2007 was analyzed to study online medication buying among a national sample of internet users (N = 5074). The Andersen Model of health care utilization guided the study's variable selection and analyses. Buying online and talking about online information are the two main outcome variables. Separate multivariate logistic regression analyses identified factors associated with online buying and factors predicting discussions with providers about online information. In 2007, 14.5% (n = 871) of internet users bought a medication or vitamin online. About 85% of online buyers had a regular provider, but only 39% talked to the provider about online information even though most (93.7%) visited the provider ≥1 times/year. Multivariate analyses found internet health product consumers were more likely to be over 50 years old, have insurance and discuss the internet with their provider than non-internet health product consumers. Moreover, discussion of internet information was more likely if consumers had a regular provider and perceived their communication to be at least fair or good in general. There is a clear association of online buying with age, frequency of visits and

  17. Simulating recurrent event data with hazard functions defined on a total time scale.

    PubMed

    Jahn-Eimermacher, Antje; Ingel, Katharina; Ozga, Ann-Kathrin; Preussler, Stella; Binder, Harald

    2015-03-08

    In medical studies with recurrent event data a total time scale perspective is often needed to adequately reflect disease mechanisms. This means that the hazard process is defined on the time since some starting point, e.g. the beginning of some disease, in contrast to a gap time scale where the hazard process restarts after each event. While techniques such as the Andersen-Gill model have been developed for analyzing data from a total time perspective, techniques for the simulation of such data, e.g. for sample size planning, have not been investigated so far. We have derived a simulation algorithm covering the Andersen-Gill model that can be used for sample size planning in clinical trials as well as the investigation of modeling techniques. Specifically, we allow for fixed and/or random covariates and an arbitrary hazard function defined on a total time scale. Furthermore we take into account that individuals may be temporarily insusceptible to a recurrent incidence of the event. The methods are based on conditional distributions of the inter-event times conditional on the total time of the preceeding event or study start. Closed form solutions are provided for common distributions. The derived methods have been implemented in a readily accessible R script. The proposed techniques are illustrated by planning the sample size for a clinical trial with complex recurrent event data. The required sample size is shown to be affected not only by censoring and intra-patient correlation, but also by the presence of risk-free intervals. This demonstrates the need for a simulation algorithm that particularly allows for complex study designs where no analytical sample size formulas might exist. The derived simulation algorithm is seen to be useful for the simulation of recurrent event data that follow an Andersen-Gill model. Next to the use of a total time scale, it allows for intra-patient correlation and risk-free intervals as are often observed in clinical trial data

  18. The Shock and Vibration Digest. Volume 15, Number 6

    DTIC Science & Technology

    1983-06-01

    Numer . Methods Engrg., 14. pp 1813-1850 (1979). 90. Dinis, L.M.S., Martins, R.A.F., and Owen, D.R.J., "Material and Geometrically Nonlinear Analysis ... Numerical Results," J. Appl. Mech., Trans. ASME, 47, pp 133-138 (1980). 145. Sathyamoorthy, M. and Prasad, M.E., Mul- tiple-Mode Nonlinear Analysis of...Andersen, CM., "Two-Stage Rayleigh-Ritz Technique for Non- linear Analysis of Structures," Proc. 2nd Intl. Symp. Innovative Numer . Anal. Appl. Engrg

  19. Condition Assessment Methodology for Spillways

    DTIC Science & Technology

    2008-06-01

    G. R., and V. H. Torrey III. 1995. Function-based condition indexing for embankment dams. J. Geotech . Engrg. ASCE, 121(8):579–588. Andersen, G.R...L. E. Chouinard, W. H. Hover, and C. W. Cox. 2001a. Risk indexing tool to assist in prioritizing improvements to embankment dams, J. Geotech . and...according to physical deficiencies. J. Geotech . and Geoenvir. Engrg., ASCE, 127(4):335–345. Chouinard, L. E., J. G. Robichaud, G. Blanchette, and R

  20. MAC/FAC: A Model of Similarity-Based Retrieval

    DTIC Science & Technology

    1994-10-01

    Grapes (0.28) 327 Sour Grapes, analog The Taming of the Shrew (0.22), Merry Wives 251 (0.18), S[11 stories], Sour Grapes (-0.19) Sour Grapes, literal... The Institute for the 0 1 Learning Sciences Northwestern University CD• 00 MAC/FAC: A MODEL OF SIMILARITY-BASED RETRIEVAL Kenneth D. Forbus Dedre...Gentner Keith Law Technical Report #59 • October 1994 94-35188 wit Establisthed in 1989 with the support of Andersen Consulting Form Approved REPORT

  1. Double Layer Structure and Electrode Kinetics.

    DTIC Science & Technology

    1980-09-30

    Extensive double layer studies were made at the water- membrane and water-mercury interfaces. The effect of the neu- tral compound phloretin , which can...used to determine the nature of the phloretin adsorption isotherm. A boxcar integration method was developed which allows us to measure short-lived...235-252. 5. R. de Levie, S. K. Rangarajan, P. F. Seelig and 0. S. Andersen, On the adsorption of phloretin onto a black lipid membrane, Biophys. J. 25

  2. Toward a National Standards Strategy Conference Report

    DTIC Science & Technology

    1999-02-01

    conducted by the CDRH (FDA) identifies four discernible characteristics relative to products and technology in the next decade. 1. Medical hardware seems...Altman FDA/ CDRH 2094 Gaither Rd. HFZ-80 Rockville, MD 20850 USA Telephone: 301/594-4766 Fax: 301/827-0193 Email: mra@cdrh.fda.gov F. Alan Andersen...642^948 Fax: 212/840-2298 Email: amarasco@ansi.org B-10 Donald Marlowe FDA/ CDRH /OST/OD 12725 Twinbrook Pkwy. HFZ-100 Rockville, MD 20850 USA

  3. The US Army and the New National Security Strategy

    DTIC Science & Technology

    2003-01-01

    transformation, the entry of the wheeled Stryker Brigade Combat Teams (SBCTs) into the operational force beginning in FY 2003 could provide some...more self-sufficient. It has established regional " hub " bases, such as the one at Andersen AFB on Guam, repositioned assets at bases where forces may...brigades $1.44 billion Missiles 1.81 Ammunition 1.81 Other procurement 4.32 Wheeled and tracked vehicles not for the Objective Force 0.71 Total $10.10 27A

  4. Periodontitis and quality of life: What is the role of socioeconomic status, sense of coherence, dental service use and oral health practices? An exploratory theory-guided analysis on a Norwegian population.

    PubMed

    Holde, Gro Eirin; Baker, Sarah R; Jönsson, Birgitta

    2018-07-01

    To utilise Andersen's behavioural model for health services' use as the theoretical framework to examine direct and indirect relationships between population characteristics, oral health behaviours and periodontitis and oral health impacts. The model was tested in a general adult population (n = 1,886) in Norway, using structural equation modelling. Socioeconomic status, sense of coherence (SOC), dental anxiety, perceived treatment need, oral health behaviours and oral health impact profile (OHIP-14) were collected through questionnaire. Periodontal examinations consisted of full-mouth recordings. Andersen's model explained a large part of the variance in use of dental services (58%) and oral health-related impacts (55%), and to a less extent periodontitis (19%). More social structure and stronger SOC was related to more enabling resources, which in turn was associated with more use of dental services. More use of dental services was related to more periodontitis and more periodontitis was associated with increased oral health impacts. A stronger SOC was associated with less oral impacts. There was no association between use of dental services and oral health impacts. The result demonstrated complex relationships between population characteristics, oral health-related behaviours and oral health outcomes. Socioeconomic factors and smoking were main predictors of periodontitis. Regular dental visiting habits did not, however, reduce the likelihood of periodontitis. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Superfund Reauthorization 1994: DoD’s Opportunity to Clean Up Its Hazardous Waste Act

    DTIC Science & Technology

    1994-04-01

    AFB AR x Edwards AFB CA x Eielson AFB AK x Ellsworth AFB SD x Elmendorf AFB AK x England AFB LA x Fairchild AFB WA x F.E. Warren AFB WY x George AFB CA...amount of toxins produced, substances such as PCBs, dioxins , cyanides, heavy metals, pesticides, residues, alkalines, and acids have been emitted into...4 TX x *AFP 144 AZ x AFP PKUS CO x Andersen AFB GU x Bergstrom AFB TX x Carswell AFB TX x Castle AFB

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhai Zehui; Guo Juan; College of Physics and Electronics Engineering, Shanxi University, Taiyuan 030006

    We propose an asymmetric quantum cloning scheme. Based on the proposal and experiment by Andersen et al. [Phys. Rev. Lett. 94, 240503 (2005)], we generalize it to two asymmetric cases: quantum cloning with asymmetry between output clones and between quadrature variables. These optical implementations also employ linear elements and homodyne detection only. Finally, we also compare the utility of symmetric and asymmetric cloning in an analysis of a squeezed-state quantum key distribution protocol and find that the asymmetric one is more advantageous.

  7. Physiologically-Based Pharmacokinetic/Toxicokinetic Modeling in Risk Assessment

    DTIC Science & Technology

    2005-03-01

    between what is considered as "kinetic" and what is "dynamic". Many models seamlessly cover both areas in order to describe the biology as a whole. In...means of Monte-Carlo analysis (Clewell and Andersen, 1989). What cannot be so easily estimated is the possible error or uncertainty introduced by the...formulated, furnished, or in any way supplied the said drawings, specifications, or other data is not to be regarded by implication or otherwise, as in any

  8. Chartbook. Quality checkup.

    PubMed

    Hudson, T

    1999-08-01

    With hospital quality programs, the reach is broad, not deep. So says the National Hospital Quality Improvement Survey, conducted by health care researcher Stephen Shortell for Arthur Andersen and the American Hospital Association. Though 93 percent of responding hospitals and health systems use CQI and TQM methods is some fashion, they've taught them to only 35 percent of employees and a scant 22 percent of doctors on their medical staffs. Those poor showings leave health care lagging behind most other industries.

  9. Computational Approach to Characterize Causative Factors and Molecular Indicators of Chronic Wound Inflammation

    DTIC Science & Technology

    2014-01-01

    Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5: 953–964. 61. Koh , T. J., and L. A. DiPietro. 2011. Inflammation and wound healing: the role...of the macrophage. Expert Rev. Mol. Med. 13: e23. 62. Mirza, R., L. A. DiPietro, and T. J. Koh . 2009. Selective and specific macrophage ablation is... Raman spectroscopic mapping. Wound Repair Regen. 18: 409–416. 66. Forsberg, J. A., E. A. Elster, R. C. Andersen, E. Nylen, T. S. Brown, M. W. Rose, A

  10. United States Air Force Summary (Consolidation of Statistical Digest and USAF Summary), Ninth Edition

    DTIC Science & Technology

    1983-01-01

    MARIANA ISLS ,..•o 8 GUAM .. o ANDERSEN AFB ,. BONIN ISLSo o o I) . o • ... .... t gO 6 ~,... ()0 KAitENA AB i"r o EAST CHINA SEA • ~. USAF MAJOR... Dave (OK) Hertel, Denni s M. (MI) Price, Melvin (IL) Bennett, Charles E. (FL) Military Personnel & Compensation Mitche 11 , Donal d J. (NY) Holt...Schroeder, Patricia (CO) Stump, Bob (AZ) Skelton, Ike (MO) Leath, James M. (TX) McCurdy, Dave (OK) Smith, Joseph F. (PA) TABLE 81 (Cont I d

  11. Improved Performance of Protected Catecholic Polysiloxanes for Bioinspired Wet Adhesion to Surface Oxides

    DTIC Science & Technology

    2012-11-26

    1374. (2) Cho, Y.; Sundaram, H. S.; Finlay , J. A.; Dimitriou, M. D.; Callow, M. E.; Callow, J. A.; Kramer, E. J.; Ober, C. K. Biomacromolecules 2012...139−144. (11) Zeng, H.; Hwang, D. S.; Israelachvili, J. N .; Waite, J. H. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 12850−12853. (12) Holten-Andersen, N ...Haeshin, L.; Dellatore, S. M.; Miller, W. M.; Messersmith, P. B. Science 2007, 318, 426−430. (14) Ling, D.; Park, W.; Park, Y. I.; Lee, N .; Li, F

  12. Making medical records professional(s).

    PubMed

    Mason, A

    1987-07-01

    In 1986 a joint medical records project group was set up by the Institute of Health Services Management, the Association of Health Care Information and Medical Records Officers and the NHS Training Authority, with Mr Vic Peel as chairman. The group was supported by Arthur Andersen & Co, management consultants. The following is a shortened and edited version of an interim report drafted for the group by Dr Alastair Mason. It is intended for discussion and does not yet represent the definitive views of the sponsoring bodies.

  13. Impacts of Energy Research and Development With Analyses of Price-Andersen Act & Hydro Relicensing

    EIA Publications

    2002-01-01

    This report deals primarily with the Research and Development provisions of S. 1766, organized across four areas: energy efficiency, renewable energy, fossil energy, and nuclear energy. The provisions are assessed using the results from Annual Energy Outlook 2002 and other side cases, rather than a direct quantitative analysis.

  14. Andersen AFB, Guam, Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

    DTIC Science & Technology

    1984-01-16

    52 at 0O30OG Jan 46-my .57 at 123oGM’ Jul 52 -MaY 57 at l230QO Jun 57-present at 12OOGHT Jun 57-present at 120OGMT B-2 tI ,1 .1J C’ =AL CLIMATOLOGY...qis 4.8 5 .97 *b3 .56 .74 .- 2.:S. 2.28 1.7% 2. 14 i.60 .4 2.25 2.5 1 .1 ._41 T 3 .71 .64 1.3Y 1.29 1.74 .81’ .9 1 .20 5 . 5 . 52 .45 .35 1.Cc .68 .𔃽...MONH JAN FfB MAR APR MAY JUN jut AUG SEP OCT NOV DEC AISYEAR MONTH 7 1.94 5.23 .8(# 3.61 2.61 9.’T1 9.42 17.72 1C. 52 3.14 ’ 169 ’.? Q19 21 1.Q 4.411

  15. Impact of culture media and sampling methods on Staphylococcus aureus aerosols.

    PubMed

    Chang, C-W; Wang, L-J

    2015-10-01

    Staphylococcus aureus has been detected indoors and is associated with human infection. Reliable quantification of S. aureus using a sampling technique followed by culture assay helps in assessing the risks of human exposure. The efficiency of five culture media and eight sampling methods in recovering S. aureus aerosols were evaluated. Methods to extract cells from filters were also studied. Tryptic soy agar (TSA) presented greater bacterial recovery than mannitol salt agar (MSA), CHROMagar staph aureus, Chapman stone medium, and Baird-Park agarose (P < 0.05). Moreover, 93 ± 2%-95 ± 2% and 42 ± 1%-49 ± 2% of S. aureus were, respectively, recovered by a 15-min heating of gelatin filters and 2-min vortex of polycarbonate (PC) filters. Evaluation of two filtration (IOM with gelatin filter and cassette with PC filter), two impaction (Andersen 1-STG loaded with TSA and MSA) and four impingement methods [AGI-30 and BioSampler filled with Tween mixture (TM) and phosphate-buffered saline (PBS)] revealed the BioSampler/TM performed best over 30 and 60 min of sampling (P < 0.05), while low recovery efficiencies were associated with the IOM/gelatin, cassette/PC, and AGI-30/PBS combinations (P < 0.05). In addition to BioSampler/TM, collecting S. aureus onto TSA from the Andersen 1-STG is also recommended, as it is the second best method at the 60-min sampling (P < 0.05). © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. The Cricotopus (Oliveiriella) (Diptera: Chironomidae) of the High Altitude Andean Streams, with Description of a New Species, C. (O.) rieradevallae.

    PubMed

    Prat, N; Paggi, A; Ribera, C; Acosta, R; Ríos-Touma, B; Villamarín, C; Rivera, F; Ossa, P; Rieradevall, M

    2018-04-01

    The genus Oliveiriella (Chironomidae, Orthocladiinae) was erected by Wiedenbrug & Fittkau (1997). The adults have characteristic black spots on their wings and other characteristics similar to the genus Cricotopus. Pupal skins are very characteristic with strong short spines in the anal lobe instead of setae, while larvae are distinguishable by the long anal papillae and the intense blue color of their body. However, Andersen et al (2013) consider Oliveiriella as a subgenera of Cricotopus. In this paper, using the sequences of the cox1 gene, we conclude that Oliveiriella should be considered a subgenus within Cricotopus, confirming its status in Andersen et al (2013). Furthermore, we describe Cricotopus (Oliveiriella) rieradevallae Prat & Paggi sp. n. from the Saltana river (Ecuador). The adult males, females, and preimaginal stages of the two species of subgenus Oliveiriella known from South America Cricotopus (O.) almeidai n. comb. from Peru, Brazil, and Argentina and Cricotopus (O.) sanjavieri n. comb. from Argentina are compared with those of Cricotopus (O.) rieradevallae sp. n. from Ecuador. The differences allow the distinction of the three species. The cox1 gene reveals that at least three different undescribed species of the same subgenus are present in the high-altitude tropical Andes. The morphology of the available pupae and pupal exuviae reveals the presence of several morphotypes that are candidates to be described as new species. A key used to distinguish these pupal morphotypes is provided, including the three described species. Additionally, the distribution of the subgenus is discussed.

  17. Hypokalaemia and dysmorphia, is there a link?

    PubMed

    Burtey, Stéphane; Sternberg, Damien; Nguyen, Karine; Philip, Nicole; Berland, Yvon; Dussol, Bertrand

    2009-06-01

    A 15-year-old boy with quadriplegia and facial dysmorphia was referred to the emergency room. This was his first episode of tetraplegia. One maternal uncle had exhibited the same manifestation 20 years before. Blood test revealed severe hypokalaemia and mild hypocalcaemia. The clinical diagnosis revealed an Andersen-Tawil syndrome. Molecular tools allowed us to make the diagnosis of familial hypokalaemic periodic paralysis type 1 associated with a de novo 22q11.2 microdeletion syndrome. Our case report emphasizes the importance of molecular diagnosis in genetic diseases.

  18. Defense Environmental Restoration Program Annual Report to Congress for Fiscal Year 1992.

    DTIC Science & Technology

    1993-04-02

    5. Eielson AFB , AK 24,336 159,535 6. Ellsworth AFB , SD 8,521 63,000 7. Elmendorf AFB , AK 23,227 107,263 8. Fairchild AFB (4 Waste Areas), WA 13,738...HRS Score (Latest) FY 92 FY 92 Status Year AIR FORCE (Continued) 7. Eielson AFB AK 48.14 92 7,055 14,799 FIN 91 8. Ellsworth AFB SD 33.62 91 690 7,831...decided at their October 7, 1992 cleanup decisions at Air Force meeting to recommend the use of . Andersen AFB , Guam installations. As part of the first

  19. DEBCat: A Catalog of Detached Eclipsing Binary Stars

    NASA Astrophysics Data System (ADS)

    Southworth, J.

    2015-07-01

    Detached eclipsing binary star systems are our primary source of measured physical properties of normal stars. I introduce DEBCat: a catalog of detached eclipsing binaries with mass and radius measurements to the 2% precision necessary to put useful constraints on theoretical models of stellar evolution. The catalog was begun in 2006, as an update of the compilation by Andersen (1991). It now contains over 170 systems, and new results are added on appearance in the refereed literature. DEBCat is available at: http://www.astro.keele.ac.uk/jkt/debcat/.

  20. United States Air Force Statistical Digest (Abridged), Fiscal Year 1991 Estimate

    DTIC Science & Technology

    1990-01-01

    AS OF: 30 APRIL 1990 0 USAF ACTIVE INSTALLATIONS m I.I.l IV FIGURE E-6 •..•o , ••o MARIANA ISLS 8 GUAM c.e ANDERSEN AFB o o o ,. BONIN ISLS o o o...Byron, Beverly B. (MD) Mavroules, Nicholas (MA) Hutto, Earl D. (Fl) Skelton, Ike (MO) leath, Marvin (TX) McCurdy, Dave (OK) Foglletta, T.M. (PA) Dyson...34 ’: :..:;"’, :.;..: ’ "".:.:..’:.::.’. DEMOCRATS Dellums, Ronald (CA) Chmn. McCurdy, Dave (OK) Foglletta, Thomas (PA) Hertel, Dennis (MI) Darden, George

  1. Test of simple fluid theories for the Lennard-Jones system

    NASA Astrophysics Data System (ADS)

    Malijevský, A.; Labik, S.

    1988-03-01

    A test is made of a new version of the reference-hypernetted chain approximation (RHNC) with minimized free energy proposed by Lado, Foiles and Ashcroft. An accurate relationship is used for the bridge function of the reference hard spheres. The calculated values of the compressibility factor and the internal energy are compared with simulation data, with results of the exponential approximation of Andersen et al., and with results of the Madden-Fitts approximation. The RHNC provides the most reliable results over wide ranges of reduced temperatures and densities.

  2. First report of Potorolepis spassky, 1994 (Eucestoda: Hymenolepididae) from China, with description of a new species in bats (Chiroptera: Rhinolophidae).

    PubMed

    Makarikova, Tatiana A; Makarikov, Arseny A

    2012-12-01

    Potorolepis gulyaevi sp. n. (Cestoda: Hymenolepididae) is described from the Chinese horseshoe bat, Rhinolophus sinicus Andersen (Chiroptera: Rhinolophidae), from southern China. The new species differs from known species of the genus by the shape, number and size of rostellar hooks, the relative position and length of the cirrus-sac and the morphology of gravid uterus. This is the first report of a member of the genus from non-marsupial mammals and the first record of a Potorolepis Spassky, 1994 from eastern Asia. The generic diagnosis of Potorolepis is amended.

  3. The utility of Pro Forma Income Statements.

    PubMed

    Reiboldt, Max; Reiboldt, John

    2002-01-01

    Recent headlines surrounding the financial demise of the nation's seventh largest company, Enron, and its subsequent entanglements with its accounting and consulting firm, Arthur Andersen, have placed a cloud of suspicion upon many reasonable business practices that otherwise are considered standard procedure. The proforma income statement is one of those practices. An oft-used tool in financial management, pro formas play a useful role for projecting financial performance based on predictable forecasts or assumptions. Regardless of the current scrutiny, there is still a valid use for accurately prepared statements.

  4. Barriers to help-seeking in men diagnosed with benign colorectal diseases.

    PubMed

    Oberoi, Devesh V; Jiwa, Moyez; McManus, Alexandra; Hodder, Rupert

    2015-01-01

    To explore the help-seeking pathway for lower bowel symptoms in men diagnosed with benign bowel diseases. Semi-structured interviews were conducted. The data were analyzed thematically using Andersen's Model of Patient Delay as the theoretical framework. The major delaying factors were attribution of symptoms to self-limiting conditions, failure to make time to visit a GP, low expectation of help from the GP, fear of cancer diagnosis and embarrassment. The major causes of delay in help-seeking were related to the participants, whereas factors associated with treatment delay were less prominent in diagnostic delay.

  5. Predisposing characteristics, enabling resources and need as predictors of utilization and clinical outcomes for veterans receiving mental health services.

    PubMed

    Fasoli, DiJon R; Glickman, Mark E; Eisen, Susan V

    2010-04-01

    Though demand for mental health services (MHS) among US veterans is increasing, MHS utilization per veteran is decreasing. With health and social service needs competing for limited resources, it is important to understand the association between patient factors, MHS utilization, and clinical outcomes. We use a framework based on Andersen's behavioral model of health service utilization to examine predisposing characteristics, enabling resources, and clinical need as predictors of MHS utilization and clinical outcomes. This was a prospective observational study of veterans receiving inpatient or outpatient MHS through Veterans Administration programs. Clinician ratings (Global Assessment of Functioning [GAF]) and self-report assessments (Behavior and Symptom Identification Scale-24) were completed for 421 veterans at enrollment and 3 months later. Linear and logistic regression analyses were conducted to examine: (1) predisposing characteristics, enabling resources, and need as predictors of MHS inpatient, residential, and outpatient utilization and (2) the association between individual characteristics, utilization, and clinical outcomes. Being older, female, having greater clinical need, lack of enabling resources (employment, stable housing, and social support), and easy access to treatment significantly predicted greater MHS utilization at 3-month follow-up. Less clinical need and no inpatient psychiatric hospitalization predicted better GAF and Behavior and Symptom Identification Scale-24 scores. White race and residential treatment also predicted better GAF scores. Neither enabling resources, nor number of outpatient mental health visits predicted clinical outcomes. This application of Andersen's behavioral model of health service utilization confirmed associations between some predisposing characteristics, need, and enabling resources on MHS utilization but only predisposing characteristics, need, and utilization were associated with clinical outcomes.

  6. Recruitment strategies for caregivers of children with mental health problems.

    PubMed

    Oruche, Ukamaka M; Gerkensmeyer, Janis E; Austin, Joan K; Perkins, Susan M; Scott, Eric; Lindsey, Laura M; Mullins, Kristen

    2012-01-01

    The aim of this study was to describe strategies for recruiting participants into an intervention study that focused on improving problem-solving skills in caregivers of children with mental health problems. Caregivers of children with mental health problems report feeling physically and psychologically overwhelmed and have high rates of depression because of the demands of caregiving. Research on the needs of these caregivers and interventions to ameliorate their stress is needed. However, recruiting this population can be particularly difficult because of the stigma of mental illness. Available literature on recruitment of caregivers of persons with physical illness cannot be transferred to caregivers of children with mental health problems because of the different caregiving situations. There is a need to identify effective recruitment strategies to reduce cost and answer research questions. Clinical nurse specialists have the skills to facilitate the recruitment of research participants. We revised and expanded health system referrals, community outreach, and recruiting advertisement (ads). When these strategies did not increase recruitment, radio ads were used. The Andersen's Behavioral Model of Health Services Utilization was selected as a guiding framework. Radio ads were the most effective strategy for recruiting caregivers of children with mental health problems for this study. Recruitment was ultimately successful because we were flexible and made decisions consistent with the Andersen's Behavioral Model of Health Services Utilization. Clinical nurse specialists who study this population of caregivers should really consider the use of radio ads and systematically track which recruitment strategies lead to the greatest number of participants screened, eligible, and enrolled into studies.

  7. Nano-colloid electrophoretic transport: Fully explicit modelling via dissipative particle dynamics

    NASA Astrophysics Data System (ADS)

    Hassanzadeh Afrouzi, Hamid; Farhadi, Mousa; Sedighi, Kurosh; Moshfegh, Abouzar

    2018-02-01

    In present study, a novel fully explicit approach using dissipative particle dynamics (DPD) method is introduced for modelling electrophoretic transport of nano-colloids in an electrolyte solution. Slater type charge smearing function included in 3D Ewald summation method is employed to treat electrostatic interaction. Moreover, capability of different thermostats are challenged to control the system temperature and study the dynamic response of colloidal electrophoretic mobility under practical ranges of external electric field in nano scale application (0.072 < E < 0.361 v / nm) covering non-linear response regime, and ionic salt concentration (0.049 < SC < 0.69 [M]) covering weak to strong Debye screening of the colloid. The effect of different colloidal repulsions are then studied on temperature, reduced mobility and zeta potential which is computed based on charge distribution within the spherical colloidal EDL. System temperature and electrophoretic mobility both show a direct and inverse relationship respectively with electric field and colloidal repulsion. Mobility declining with colloidal repulsion reaches a plateau which is a relatively constant value at each electrolyte salinity for Aii > 600 in DPD units regardless of electric field intensity. Nosé-Hoover-Lowe-Andersen and Lowe-Andersen thermostats are found to function more effectively under high electric fields (E > 0.145 [ v / nm ]) while thermal equilibrium is maintained. Reasonable agreements are achieved by benchmarking the radial distribution function with available electrolyte structure modellings, as well as comparing reduced mobility against conventional Smoluchowski and Hückel theories, and numerical solution of Poisson-Boltzmann equation.

  8. Air traffic controller lightning strike.

    PubMed Central

    Spieth, M. E.; Kimura, R. L.; Schryer, T. D.

    1994-01-01

    Andersen Air Force Base in Guam boasts the tallest control tower in the Air Force. In 1986, an air traffic controller was struck by lightning as the bolt proceeded through the tower. Although he received only a backache, the lightning left a hole with surrounding scorch marks on his fatigue shirt and his undershirt. The lightning strike also ignited a portion of the field lighting panel, which caused the runway lights to go out immediately. Lack of a lightning rod is the most likely reason the controller was struck. Proper precautions against lightning strikes can prevent such occupational safety hazards. PMID:7966436

  9. Chaotic oscillations and noise transformations in a simple dissipative system with delayed feedback

    NASA Astrophysics Data System (ADS)

    Zverev, V. V.; Rubinstein, B. Ya.

    1991-04-01

    We analyze the statistical behavior of signals in nonlinear circuits with delayed feedback in the presence of external Markovian noise. For the special class of circuits with intense phase mixing we develop an approach for the computation of the probability distributions and multitime correlation functions based on the random phase approximation. Both Gaussian and Kubo-Andersen models of external noise statistics are analyzed and the existence of the stationary (asymptotic) random process in the long-time limit is shown. We demonstrate that a nonlinear system with chaotic behavior becomes a noise amplifier with specific statistical transformation properties.

  10. Here or There: Recent U.S. Immigrants' Medical and Dental Tourism and Associated Factors.

    PubMed

    Jang, Sou Hyun

    2018-01-01

    Applying Andersen's health care utilization model, this paper shows the prevalence of immigrants' medical and dental tourism and associated factors. An analysis of the 2003 New Immigrant Survey data shows that about 17% of immigrants received medical care in a foreign country, whereas about one-third obtained dental care outside the United States. Latino immigrants have a higher prevalence of both types of tourism than their Asian counterparts. Race, level of education, and health insured status are commonly associated with medical and dental tourism. The findings contribute to the scarce literature on immigrants' health care utilization and medical and dental tourism.

  11. Home care for children with multiple complex chronic conditions at the end of life: The choice of hospice versus home health.

    PubMed

    Lindley, Lisa C; Mixer, Sandra J; Mack, Jennifer W

    2016-01-01

    Families desire to bring their children home at end of life, and this creates a variety of unique care needs at home. This study analyzed the child and family factors associated with hospice versus home health care use in the last year of life among children with multiple complex chronic conditions. Using the Andersen Behavioral Healthcare Utilization Model, the predisposing, enabling, and need factors of the child and family were shown to be significant predictors of hospice and home health care use. Hospice and home health care have advantages, and families may wish to use the service that best fits their needs.

  12. Mask quality assessment

    NASA Astrophysics Data System (ADS)

    Regis, Larry; Paulson, Neil; Reynolds, James A.

    1994-02-01

    Product quality and timely delivery are two of the most important parameters, determining the success of a mask manufacturing facility. Because of the sensitivity of this data, however, very little is known about industry performance in these areas. Using Arthur Andersen & Co. to protect contributor identity, the authors have conducted a blind quality survey of mask shops which represents over 75% of the total merchant and captive mask volume in the US. Quantities such as return rate, plate survival yield, performance to schedule and reason for return were requested from 1988 through Q2 1993. Data is analyzed and conclusions are presented.

  13. How to help teachers' voices.

    PubMed

    Saatweber, Margarete

    2008-01-01

    It has been shown that teachers are at high risk of developing occupational dysphonia, and it has been widely accepted that the vocal characteristics of a speaker play an important role in determining the reactions of listeners. The functions of breathing, breathing movement, breathing tonus, voice vibrations and articulation tonus are transmitted to the listener. So we may conclude that listening to the teacher's voice at school influences children's behavior and the perception of spoken language. This paper presents the concept of Schlaffhorst-Andersen including exercises to help teachers improve their voice, breathing, movement and their posture. Copyright 2008 S. Karger AG, Basel.

  14. Symposium on Turbulent Shear Flows (3rd), University of California, Davis, California, 9-11 September 1981.

    DTIC Science & Technology

    1981-09-01

    1970, p. 417. 16 Wieghardt, K., Tillmann, W., "On the Turbulent Friction Layer for Rising Pressure", NACA, TM 1374, 1957. 17 Andersen, P.S., Kays, W.M...thickness is 5000. derived from the "Strong Reynolds Analogy" (S.R.A.) A 12 eeg . deflection of the wall around a sharp edge may be us d o ep es nt p~-- o Tu...which yields (3) / / 02 /S - t 02 S = Se-t boundayI y,0in flame I with so as the initial shear layer thickness. zonemod 2S 10 / tms 2. Initial

  15. Effect of impact stress on microbial recovery on an agar surface.

    PubMed Central

    Stewart, S L; Grinshpun, S A; Willeke, K; Terzieva, S; Ulevicius, V; Donnelly, J

    1995-01-01

    Microbial stress due to the impaction of microorganisms onto an agar collection surface was studied experimentally. The relative recovery rates of aerosolized Pseudomonas fluorescens and Micrococcus luteus were determined as a function of the impaction velocity by using a moving agar slide impactor operating over a flow rate range from 3.8 to 40 liters/min yielding impaction velocities from 24 to 250 m/s. As a reference, the sixth stage of the Andersen Six-Stage Viable Particle Sizing Sampler was used at its operating flow rate of 28.3 liters/min (24 m/s). At a collection efficiency of close to 100% for the agar slide impactor, an increase in sampling flow rate and, therefore, in impaction velocity produced a significant decline in the percentage of microorganisms recovered. Conversely, when the collection efficiency was less than 100%, greater recovery and lower injury rates occurred. The highest relative rate of recovery (approximately 51% for P. fluorescens and approximately 62% for M. luteus) was obtained on the complete (Trypticase soy agar) medium at 40 and 24 m/s (6.4 and 3.8 liters/min), respectively. M. luteus demonstrated less damage than P. fluorescens, suggesting the hardy nature of the gram-positive strain versus that of the gram-negative microorganism. Comparison of results from the agar slide and Andersen impactors at the same sampling velocity showed that recovery and injury due to collection depends not only on the magnitude of the impaction velocity but also on the degree to which the microorganisms may be embedded in the collection medium.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7747946

  16. Rural-Urban Differences in Preventable Hospitalizations Among Community-Dwelling Veterans with Dementia

    PubMed Central

    Thorpe, Joshua M.; Van Houtven, Courtney H.; Sleath, Betsy L.; Thorpe, Carolyn T.

    2013-01-01

    Context Alzheimer’s patients living in rural communities may face significant barriers to effective outpatient medical care. Purpose We sought to examine rural-urban differences in risk for ambulatory care sensitive hospitalizations (ACSH), an indicator of access to outpatient care, in community-dwelling veterans with dementia. Methods Medicare and VA inpatient claims for 1,186 United States veterans with dementia were linked to survey data from the 1998 National Longitudinal Caregiver Survey. ACSH were identified in inpatient claims over a one-year period following collection of independent variables. Urban Influence Codes were used to classify care-recipients into four categories of increasing county-level rurality: large metropolitan; small metropolitan; micropolitan; and non-core rural counties. We used the Andersen Behavioral Model of Health Services Use to identify veteran, caregiver, and community factors that may explain urban-rural differences in ACSH. Findings Thirteen percent of care-recipients had at least one ACSH. Likelihood of ACSH was greater for patients in non-core rural counties versus large metropolitan areas (22.6% versus 12.8%, unadjusted odds ratio [OR] = 1.99; p < .05). The addition of other Andersen behavioral model variables did not eliminate the disparity (adjusted OR = 1.97; p < .05). Conclusions We found that dementia patients living in the most rural counties were more likely to have an ACSH; this disparity was not explained by differences in caregiver, care-recipient, or community factors. Furthermore, the annual rate of ACSH was higher in community-dwelling dementia patients compared to previous reports on the general older adult population. Dementia patients in rural areas may face particular challenges in receiving timely, effective ambulatory care. PMID:20447001

  17. Discriminant forest classification method and system

    DOEpatents

    Chen, Barry Y.; Hanley, William G.; Lemmond, Tracy D.; Hiller, Lawrence J.; Knapp, David A.; Mugge, Marshall J.

    2012-11-06

    A hybrid machine learning methodology and system for classification that combines classical random forest (RF) methodology with discriminant analysis (DA) techniques to provide enhanced classification capability. A DA technique which uses feature measurements of an object to predict its class membership, such as linear discriminant analysis (LDA) or Andersen-Bahadur linear discriminant technique (AB), is used to split the data at each node in each of its classification trees to train and grow the trees and the forest. When training is finished, a set of n DA-based decision trees of a discriminant forest is produced for use in predicting the classification of new samples of unknown class.

  18. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Olivares, Stefano; Paris, Matteo G. A.; Andersen, Ulrik L.

    We analyze in details a scheme for cloning of Gaussian states based on linear optical components and homodyne detection recently demonstrated by Andersen et al. [Phys. Rev. Lett. 94, 240503 (2005)]. The input-output fidelity is evaluated for a generic (pure or mixed) Gaussian state taking into account the effect of nonunit quantum efficiency and unbalanced mode mixing. In addition, since in most quantum information protocols the covariance matrix of the set of input states is not perfectly known, we evaluate the average cloning fidelity for classes of Gaussian states with the degree of squeezing and the number of thermal photonsmore » being only partially known.« less

  19. Note: Nonpolar solute partial molar volume response to attractive interactions with water.

    PubMed

    Williams, Steven M; Ashbaugh, Henry S

    2014-01-07

    The impact of attractive interactions on the partial molar volumes of methane-like solutes in water is characterized using molecular simulations. Attractions account for a significant 20% volume drop between a repulsive Weeks-Chandler-Andersen and full Lennard-Jones description of methane interactions. The response of the volume to interaction perturbations is characterized by linear fits to our simulations and a rigorous statistical thermodynamic expression for the derivative of the volume to increasing attractions. While a weak non-linear response is observed, an average effective slope accurately captures the volume decrease. This response, however, is anticipated to become more non-linear with increasing solute size.

  20. Particle Size Distribution of Serratia marcescens Aerosols Created During Common Laboratory Procedures and Simulated Laboratory Accidents

    PubMed Central

    Kenny, Michael T.; Sabel, Fred L.

    1968-01-01

    Andersen air samplers were used to determine the particle size distribution of Serratia marcescens aerosols created during several common laboratory procedures and simulated laboratory accidents. Over 1,600 viable particles per cubic foot of air sampled were aerosolized during blending operations. More than 98% of these particles were less than 5 μ in size. In contrast, 80% of the viable particles aerosolized by handling lyophilized cultures were larger than 5 μ. Harvesting infected eggs, sonic treatment, centrifugation, mixing cultures, and dropping infectious material produced aerosols composed primarily of particles in the 1.0- to 7.5-μ size range. Images Fig. 1 PMID:4877498

  1. Plate falling in a fluid: Regular and chaotic dynamics of finite-dimensional models

    NASA Astrophysics Data System (ADS)

    Kuznetsov, Sergey P.

    2015-05-01

    Results are reviewed concerning the planar problem of a plate falling in a resisting medium studied with models based on ordinary differential equations for a small number of dynamical variables. A unified model is introduced to conduct a comparative analysis of the dynamical behaviors of models of Kozlov, Tanabe-Kaneko, Belmonte-Eisenberg-Moses and Andersen-Pesavento-Wang using common dimensionless variables and parameters. It is shown that the overall structure of the parameter spaces for the different models manifests certain similarities caused by the same inherent symmetry and by the universal nature of the phenomena involved in nonlinear dynamics (fixed points, limit cycles, attractors, and bifurcations).

  2. Morphologic aspects of Tetratrichomonas didelphidis isolated from opossums Didelphis marsupialis and Lutreolina crassicaudata.

    PubMed

    Tasca, T; De Carli, G A; Glock, L; Jeckel-Neto, E A

    2001-02-01

    Tetratrichomonas didelphidis (Hegner & Ratcliffe, 1927) Andersen & Reilly, 1965 is a flagellate protozoan found in the intestine, cecum, and colon of Didelphis marsupialis. The parasitic protozoa used in this study was found and isolated in the intestine of opossums in Pavlova starch-containing medium in Florianópolis, State of Santa Catarina, Brazil, from D. marsupialis and Lutreolina crassicaudata. The strains were cultivated in Diamond medium without maltose and with starch solution, pH 7.5 at 28 degrees C. The specimens were stained by the Giemsa method and Heidenhain's iron hematoxylin. The light microscopy study of the trophozoites revealed the same morphologic characteristics as specimens previously described.

  3. Note: Nonpolar solute partial molar volume response to attractive interactions with water

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Williams, Steven M.; Ashbaugh, Henry S., E-mail: hanka@tulane.edu

    2014-01-07

    The impact of attractive interactions on the partial molar volumes of methane-like solutes in water is characterized using molecular simulations. Attractions account for a significant 20% volume drop between a repulsive Weeks-Chandler-Andersen and full Lennard-Jones description of methane interactions. The response of the volume to interaction perturbations is characterized by linear fits to our simulations and a rigorous statistical thermodynamic expression for the derivative of the volume to increasing attractions. While a weak non-linear response is observed, an average effective slope accurately captures the volume decrease. This response, however, is anticipated to become more non-linear with increasing solute size.

  4. Investigation of electrolytes utilized for high-voltage LiNi0.5Mn1.5O4 batteries

    NASA Astrophysics Data System (ADS)

    Qin, Yinping; Lin, Huan; Liu, Yang; Wang, Deyu

    2017-10-01

    The main challenge of high-voltage LiNi0.5Mn1.5O4 (LNMO), which is one of the most promising cathodes with the redox plateau of ˜4.75V vs Li+/Li, is the decomposition of electrolyte. In fact, our studies show that LNMO presents the good capacity retention ratio, higher than 80% after 300 cycles, in the electrolyte with the mixture of pure carbonate solvents. Even 92% of the initial capacity in the 300th cycle is remained in the optimal composition. Obviously, high-voltage LiNi0.5Mn1.5O4 can get excellent cycle performance without any special additives. In addition, we studied the electrochemical behavior of viny lene carbonate (VC) and ethylene sulfite (ES) in high potential. The results indicate that VC and ES can be electrochemically oxidized at 4.6 V and 4.05 V vs Li+/Li, respectively. In the cells with the electrolytes containing VC and ES respectively, the discharge capacities are significantly diminished. Also, the thick and high-resistance sediment layers are formed on the surface of LNMO. We concluded that the SEI-forming additives widely used in commercial batteries may firstly decompose on cathode side. Therefore, the electrolyte systems should be redesigned for graphite-LNMO batteries.

  5. In vitro fermentation characteristics of two mushroom species, an herb, and their polysaccharide fractions, using chicken cecal contents as inoculum.

    PubMed

    Guo, F C; Williams, B A; Kwakkel, R P; Verstegen, M W A

    2003-10-01

    In vitro fermentabilities of two mushrooms (Lentinus edodes--LenS; Tremella fuciformis--TreS), an herb (Astragalus membranaceus--AstS), and their polysaccharide fractions (LenE, TreE, and AstE) were investigated using microflora from chicken ceca. Polysaccharides were extracted using the hot water method. The mushrooms had lower polysaccharide yields (8 to 10%) than the herb (31%). Fermentation kinetics were determined using the in vitro cumulative gas production technique. End-products, such as gas, volatile fatty acids (VFA), and ammonia, were also determined. The gas profiles of intact materials were similar for AstS and LenS. The TreS had a diphasic digestion pattern. The extracts had similar profiles to the intact materials though gas production rates were faster. Intact materials tended to produce less VFA than the extracts though LenS and AstE had the highest total VFA production overall. Intact materials contained more protein than the extracts, and therefore resulted in more branched-chain fatty acids and ammonia. Fermentation kinetics and end-point products demonstrated differences in availability of substrates between the mushrooms and herb. These medicinal mushroom and herb materials, particularly their polysaccharide extracts, show promise in altering microbial activities and composition in chicken ceca. In vivo experiments are necessary for confirmation of this hypothesis.

  6. Mental health service use by cleanup workers in the aftermath of the Deepwater Horizon oil spill.

    PubMed

    Lowe, Sarah R; Kwok, Richard K; Payne, Julianne; Engel, Lawrence S; Galea, Sandro; Sandler, Dale P

    2015-04-01

    High rates of mental health (MH) problems have been documented among disaster relief workers. However, few workers utilize MH services, and predictors of service use among this group remain unexplored. The purpose of this study was to explore associations between predisposing, illness-related, and enabling factors from Andersen's behavioral model of treatment-seeking and patterns of service use among participants who completed at least one full day of cleanup work after the Deepwater Horizon oil spill and participated in home visits for the NIEHS GuLF STUDY (N = 8931). Workers reported on MH symptoms and whether they had used counseling or medication for MH problems since the oil spill. Hierarchical logistic regression models explored associations between predictors and counseling and medication use in the full sample, and type of use (counseling only, medication only, both) among participants who used either service. Analyses were replicated for subsamples of participants with and without symptom inventory scores suggestive of probable post-disaster mental illness. Having a pre-spill MH diagnosis, pre-spill service use, more severe post-spill MH symptoms, and healthcare coverage were positively associated with counseling and medication use in the full sample. Among participants who used either service, non-Hispanic Black race, pre-spill counseling, lower depression, and not identifying a personal doctor or healthcare provider were predictive of counseling only, whereas older age, female gender and pre-spill medication were predictive of medication only. The results were generally consistent among participants with and without probable post-disaster mental illness. The results suggest variability in which factors within Andersen's behavioral model are predictive of different patterns of service use among disaster relief workers. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. The variable presentations of glycogen storage disease type IV: a review of clinical, enzymatic and molecular studies.

    PubMed

    Moses, Shimon W; Parvari, Ruti

    2002-03-01

    Glycogen storage disease type IV (GSD-IV), also known as Andersen disease or amylopectinosis (MIM 23250), is a rare autosomal recessive disorder caused by a deficiency of glycogen branching enzyme (GBE) leading to the accumulation of amylopectin-like structures in affected tissues. The disease is extremely heterogeneous in terms of tissue involvement, age of onset and clinical manifestations. The human GBE cDNA is approximately 3-kb in length and encodes a 702-amino acid protein. The GBE amino acid sequence shows a high degree of conservation throughout species. The human GBE gene is located on chromosome 3p14 and consists of 16 exons spanning at least 118 kb of chromosomal DNA. Clinically the classic Andersen disease is a rapidly progressive disorder leading to terminal liver failure unless liver transplantation is performed. Several mutations have been reported in the GBE gene in patients with classic phenotype. Mutations in the GBE gene have also been identified in patients with the milder non-progressive hepatic form of the disease. Several other variants of GSD-IV have been reported: a variant with multi-system involvement including skeletal and cardiac muscle, nerve and liver; a juvenile polysaccharidosis with multi-system involvement but normal GBE activity; and the fatal neonatal neuromuscular form associated with a splice site mutation in the GBE gene. Other presentations include cardiomyopathy, arthrogryposis and even hydrops fetalis. Polyglucosan body disease, characterized by widespread upper and lower motor neuron lesions, can present with or without GBE deficiency indicating that different biochemical defects could result in an identical phenotype. It is evident that this disease exists in multiple forms with enzymatic and molecular heterogeneity unparalleled in the other types of glycogen storage diseases.

  8. The effects of catastrophic ecosystem disturbance: the residual mammals at Mount St. Helens

    USGS Publications Warehouse

    Andersen, Douglas C.; MacMahon, James A.

    1985-01-01

    Individuals that survive the direct effects of community- or ecosystem-level disturbances, i.e., "residuals", can have major roles in determining the rate and pathway of subsequent secondary succession. The explosive eruption of the Mount St. Helens volcano on 19 May 1980 resulted in severe damage to a cast array of animal and plant populations (Edwards and Schwartz, 1981; MacMahon, 1982; Hayward et al., 1982). We apply the term "catastrophic" to this event because of its intensity and the large area (>600 km2) over which successional processes were initiated. We present here the results of surveys for mammals, particularly small mammals (excluding bats), conducted in the Mount St. Helens region during the 40 months following the eruption. Our purpose was to elucidate any patterns in species representation that might exist along a gradient of disturbance "intensity", and thus document which species could potentially influence early plant successional patterns there. We infer whether individuals captured were more likely to have been residuals (or their descendants), or immigrants from areas less affected by the eruption, from consideration of the time span between the eruption and the capture date, the trapping location, and life history data. We also make inferences concerning the animal-environment relationships that led to our survey results, and thereby address the question of the likelihood of other types of disturbance, either natural or anthropogenic, producing similar results. Data concerning survival of Thomomys talpoides, the northern pocket gopher, have been presented elsewhere (Andersen, 1982). Initial results from our studies of the relationships among residual small mammals and plant population dynamics are detailed in MacMahon and Warner (1984), Allen et al. (1984) and Andersen and MacMahon (in press).

  9. A systematic comparison of recurrent event models for application to composite endpoints.

    PubMed

    Ozga, Ann-Kathrin; Kieser, Meinhard; Rauch, Geraldine

    2018-01-04

    Many clinical trials focus on the comparison of the treatment effect between two or more groups concerning a rarely occurring event. In this situation, showing a relevant effect with an acceptable power requires the observation of a large number of patients over a long period of time. For feasibility issues, it is therefore often considered to include several event types of interest, non-fatal or fatal, and to combine them within a composite endpoint. Commonly, a composite endpoint is analyzed with standard survival analysis techniques by assessing the time to the first occurring event. This approach neglects that an individual may experience more than one event which leads to a loss of information. As an alternative, composite endpoints could be analyzed by models for recurrent events. There exists a number of such models, e.g. regression models based on count data or Cox-based models such as the approaches of Andersen and Gill, Prentice, Williams and Peterson or, Wei, Lin and Weissfeld. Although some of the methods were already compared within the literature there exists no systematic investigation for the special requirements regarding composite endpoints. Within this work a simulation-based comparison of recurrent event models applied to composite endpoints is provided for different realistic clinical trial scenarios. We demonstrate that the Andersen-Gill model and the Prentice- Williams-Petersen models show similar results under various data scenarios whereas the Wei-Lin-Weissfeld model delivers effect estimators which can considerably deviate under commonly met data scenarios. Based on the conducted simulation study, this paper helps to understand the pros and cons of the investigated methods in the context of composite endpoints and provides therefore recommendations for an adequate statistical analysis strategy and a meaningful interpretation of results.

  10. Determinants analysis of outpatient service utilisation in Georgia: can the approach help inform benefit package design?

    PubMed

    Gotsadze, George; Tang, Wenze; Shengelia, Natia; Zoidze, Akaki

    2017-05-02

    The healthcare financing reforms initiated by the Government of Georgia in 2007 have positively affected inpatient service utilisation and enhanced financial protection, especially for the poor, but they have failed to facilitate outpatient service use among chronic patients. Non-communicable diseases significantly affect Georgia's ageing population. Consequently, in this paper, we look at the evidence emerging from determinants analysis of outpatient service utilisation and if the finding can help identify possible policy choices in Georgia, especially regarding benefit package design for individuals with chronic conditions. We used Andersen's behavioural model of health service utilisation to identify the critical determinants that affect outpatient service use. A multinomial logistic regression was carried out with complex survey design using the data from two nationally representative cross-sectional population-based health utilisation and expenditure surveys conducted in Georgia in 2007 and 2010, which allowed us to assess the relationship between the determinants and outpatient service use. The study revealed the determinants that significantly impede outpatient service use. Low income, 45- to 64-year-old Georgian males with low educational attainment and suffering from a chronic health problem have the lowest odds for service use compared to the rest of the population. Using Andersen's behavioural model and assessing the determinants of outpatient service use has the potential to inform possible policy responses, especially those driving services use among chronic patients. The possible policy responses include reducing financial access barriers with the help of public subsidies for sub-groups of the population with the lowest access to care; focusing/expanding state-funded benefits for the most prevalent chronic conditions, which are responsible for the greatest disease burden; or supporting chronic disease management programs for the most prevalent chronic

  11. Finite-Size Scaling of a First-Order Dynamical Phase Transition: Adaptive Population Dynamics and an Effective Model

    NASA Astrophysics Data System (ADS)

    Nemoto, Takahiro; Jack, Robert L.; Lecomte, Vivien

    2017-03-01

    We analyze large deviations of the time-averaged activity in the one-dimensional Fredrickson-Andersen model, both numerically and analytically. The model exhibits a dynamical phase transition, which appears as a singularity in the large deviation function. We analyze the finite-size scaling of this phase transition numerically, by generalizing an existing cloning algorithm to include a multicanonical feedback control: this significantly improves the computational efficiency. Motivated by these numerical results, we formulate an effective theory for the model in the vicinity of the phase transition, which accounts quantitatively for the observed behavior. We discuss potential applications of the numerical method and the effective theory in a range of more general contexts.

  12. Racial/ethnic variation in health care satisfaction: The role of acculturation.

    PubMed

    Han, Woojae; Lee, Sungkyu

    2016-10-01

    This study examined the role of acculturation and racial/ethnic variation in health care satisfaction among four different racial/ethnic groups. The study sample consisted of 41,560 adults from the 2011 California Health Interview Survey. Health care satisfaction was measured via two questions regarding doctors' listening and explanations. Guided by Andersen's behavioral model of health care use, multivariate logistic regressions were conducted. Hispanic and Asian respondents showed the lowest levels of satisfaction with their doctors' listening and explanations, respectively. Acculturation was found to be a significant predictor of health care satisfaction. Health care professionals should develop ways of expanding culturally competent health care professionals, who are aware of racial/ethnic variation in health care satisfaction.

  13. [Historical compilation of cystic fibrosis].

    PubMed

    Navarro, Salvador

    2016-01-01

    Cystic fibrosis is the most common life-shortening recessively inherited disorder in the Caucasian population. The genetic mutation that most frequently provokes cystic fibrosis (ΔF508) appeared at least 53,000years ago. For many centuries, the disease was thought to be related to witchcraft and the "evil eye" and it was only in 1938 that Dorothy H. Andersen characterized this disorder and suspected its genetic origin. The present article reviews the pathological discoveries and diagnostic and therapeutic advances made in the last 75 years. The review ends with some considerations for the future. Copyright © 2015 Elsevier España, S.L.U. and AEEH y AEG. All rights reserved.

  14. Experimental and ab initio molecular dynamics simulation studies of liquid Al60Cu40 alloy

    NASA Astrophysics Data System (ADS)

    Wang, S. Y.; Kramer, M. J.; Xu, M.; Wu, S.; Hao, S. G.; Sordelet, D. J.; Ho, K. M.; Wang, C. Z.

    2009-04-01

    X-ray diffraction and ab initio molecular dynamics simulation studies of molten Al60Cu40 have been carried out between 973 and 1323 K. The structures obtained from our simulated atomic models are fully consistent with the experimental results. The local structures of the models analyzed using Honeycutt-Andersen and Voronoi tessellation methods clearly demonstrate that as the temperatures of the liquid is lowered it becomes more ordered. While no one cluster-type dominates the local structure of this liquid, the most prevalent polyhedra in the liquid structure can be described as distorted icosahedra. No obvious correlations between the clusters observed in the liquid and known stable crystalline phases in this system were observed.

  15. New approach to study mobility in the vicinity of dynamical arrest; exact application to a kinetically constrained model

    NASA Astrophysics Data System (ADS)

    DeGregorio, P.; Lawlor, A.; Dawson, K. A.

    2006-04-01

    We introduce a new method to describe systems in the vicinity of dynamical arrest. This involves a map that transforms mobile systems at one length scale to mobile systems at a longer length. This map is capable of capturing the singular behavior accrued across very large length scales, and provides a direct route to the dynamical correlation length and other related quantities. The ideas are immediately applicable in two spatial dimensions, and have been applied to a modified Kob-Andersen type model. For such systems the map may be derived in an exact form, and readily solved numerically. We obtain the asymptotic behavior across the whole physical domain of interest in dynamical arrest.

  16. Enhancing Supply Chain Performance with Environmental Cost Information: Examples from Commonwealth Edison, Andersen Corporation, and Ashland Chemical

    EPA Pesticide Factsheets

    This collection of case studies illustrates how supply chain management practices can be improved by determining the financial impact of business activities that have an impact on a company’s environmental performance.

  17. Magma-poor and magma-rich segments along the hyperextended, pre-Caledonian passive margin of Baltica

    NASA Astrophysics Data System (ADS)

    Andersen, Torgeir B.; Alsaif, Manar; Corfu, Fernando; Jakob, Johannes; Planke, Sverre; Tegner, Christian

    2015-04-01

    The Scandinavian Caledonides constitute a more than 1850 km long 'Himalayan-type' orogen, formed by collision between Baltica-Avalonia and Laurentia. Subduction-related magmatism in the Iapetus ended at ~430 Ma and continental convergence continued for ~30 Myr until ~400 Ma. The collision produced a thick orogenic wedge comprising the stacked remnants of the rifted to hyperextended passive Baltican margin (Andersen et al. 2012), as well as suspect, composite and outboard terranes, which were successively emplaced as large-scale nappe complexes onto Baltica during the Scandian collision (see Corfu et al. 2014 for a recent review). Large parts (~800 km) of the mountain-belt in central Scandinavia, particularly in the Särv and Seve Nappes and their counterparts in Troms, are characterised by spectacular dyke complexes emplaced into continental sediments (e.g. Svenningsen 2001, Hollocher et al. 2007). These constitute a magma-rich segment formed along the margin of Baltica or within hyperextended continental slivers outboard of Baltica. The intensity of the pre-Caledonian magmatism is comparable to that of the present NE-Atlantic and other volcanic passive margins. The volumes and available U-Pb ages of 610-597 Ma (Baird et al. 2014 and refs therein) suggest that the magmatism was short lived, intense and therefore compatible with a large igneous province (LIP). By analogy with present-day margins this LIP may have been associated with continental break-up and onset of sea-floor spreading. The remnants of the passive margin both north and south of the magma-rich segment have different architectures, and are almost devoid of rift/drift related magmatic rocks. Instead, these magma-poor segments are dominated by heterogeneous sediment-filled basins characterised by the abundant presence of solitary bodies of variably altered mantle peridotites, also commonly present as detrital serpentinites. These basins are interpreted to have formed by hyperextension. We suggest that

  18. RCT of a Psychological Intervention for Patients With Cancer: I. Mechanisms of Change

    PubMed Central

    Andersen, Barbara L.; Shelby, Rebecca A.; Golden-Kreutz, Deanna M.

    2008-01-01

    Little is known about the therapeutic processes contributing to efficacy of psychological interventions for patients with cancer. Data from a randomized clinical trial yielding robust biobehavioral and health effects (B. L. Andersen et al., 2004, 2007) were used to examine associations between process variables, treatment utilization, and outcomes. Novel findings emerged. Patients were highly satisfied with the treatment, but their higher levels of felt support (group cohesion) covaried with lower distress and fewer symptoms. Also, specific. treatment strategies were associated with specific outcomes, including lower distress, improved dietary habits, reduced symptomatology, and higher chemotherapy dose intensity. These data provide a comprehensive test of multiple therapeutic processes and mechanisms for biobehavioral change with an intervention including both intensive and maintenance phases. PMID:18085909

  19. GPU accelerated Discrete Element Method (DEM) molecular dynamics for conservative, faceted particle simulations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spellings, Matthew; Biointerfaces Institute, University of Michigan, 2800 Plymouth Rd., Ann Arbor, MI 48109; Marson, Ryan L.

    Faceted shapes, such as polyhedra, are commonly found in systems of nanoscale, colloidal, and granular particles. Many interesting physical phenomena, like crystal nucleation and growth, vacancy motion, and glassy dynamics are challenging to model in these systems because they require detailed dynamical information at the individual particle level. Within the granular materials community the Discrete Element Method has been used extensively to model systems of anisotropic particles under gravity, with friction. We provide an implementation of this method intended for simulation of hard, faceted nanoparticles, with a conservative Weeks–Chandler–Andersen (WCA) interparticle potential, coupled to a thermodynamic ensemble. This method ismore » a natural extension of classical molecular dynamics and enables rigorous thermodynamic calculations for faceted particles.« less

  20. Intermediate-depth earthquake generation: what hydrous minerals can tell us

    NASA Astrophysics Data System (ADS)

    Deseta, N.; Ashwal, L.; Andersen, T. B.

    2012-04-01

    Subduction zone seismicity has commonly been causally related to the dehydration of minerals within the subducting slab(Hacker et al. 2004, Jung et al. (2004), Dobson et al. 2002, Rondenay et al. 2008). Other models for release of intermediate- and deep earthquakes include spontaneous reaction(s) affecting large rock-bodies along overstepped phase boundaries ( e.g. Green and Houston, 1995) and various shear heating-localization models (e.g. Kelemen and Hirth 2007, John et al. 2009). These concepts are principally reliant on seismic and thermo-petrological modeling; both of which are indirect methods of analysis. Recent discoveries of pseudotachylytes (PST) formed under high pressure conditions (Ivrea-Verbano Zone, Italy, Western Gneiss Region, Norway and Corsica) provide the first tangible opportunity to evaluate these models (Austrheim and Andersen, 2004, Lund and Austrheim, 2003, Obata and Karato, 1995, Jin et al., 1998). This case study focuses on observations based on ultramafic and mafic PST within the Ligurian Ophiolite of the high pressure-low temperature metamorphic (HP-LT) 'Shistes Lustres' complex in Cima di Gratera, Corsica (Andersen et al. 2008). These PST have been preserved in pristine lenses of peridotite and gabbro surrounded by schistose serpentinites. The PST range in thickness from 1mm to 25 cm (Andersen and Austrheim, 2006). Petrography and geochemistry on PST from the peridotite and gabbro samples indicates that total/near-total fusion of the local host rock mineral assemblage occurred; bringing up the temperature of shear zone from 350° C to 1400 - 1700° C; depending on the host rock (Andersen and Austrheim, 2006). The composition of the PST is highly variable, even at the thin section scale and this has been attributed to the coarse-grained nature of the host rock, its small scale inhomogeneity and poor mixing of the fusion melt. Almost all the bulk analyses of the PST are hydrous; the peridotitic PST is always hydrous (H2O content from 3

  1. 40 CFR 721.5960 - N,N′-Bis(2-(2-(3-alkyl)thia- zoline) vinyl)-1,4-pheny-lene-dia-mine methyl sulfate double salt...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...), (f) (concentration set at 1 percent), (g)(1)(iii), (g)(1), (may be lethal if inhaled or in contact with eyes), (g)(2)(i), (g)(2)(ii), (g)(2)(iv), (g)(2)(v), and (g)(5). The provision of § 721.72(d...

  2. 40 CFR 721.5960 - N,N′-Bis(2-(2-(3-alkyl)thia- zoline) vinyl)-1,4-pheny-lene-dia-mine methyl sulfate double salt...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...), (f) (concentration set at 1 percent), (g)(1)(iii), (g)(1), (may be lethal if inhaled or in contact with eyes), (g)(2)(i), (g)(2)(ii), (g)(2)(iv), (g)(2)(v), and (g)(5). The provision of § 721.72(d...

  3. (18-Crown-6)potassium [(1,2,5,6-η)-cyclo-octa-1,5-diene][(1,2,3,4-η)-naph-tha-lene]-ferrate(-I).

    PubMed

    Brennessel, William W; Ellis, John E

    2012-10-01

    The title salt, [K(C(12)H(24)O(6))][Fe(C(8)H(12))(C(10)H(8))], is the only known naphthalene complex containing iron in a formally negative oxidation state. Each (naphthalene)(1,5-cod)ferrate(-I) anion is in contact with one (18-crown-6)potassium cation via K⋯C contacts to the outer four carbon atoms of the naphthalene ligand (cod = 1,5-cyclo-octa-diene, 18-crown-6 = 1,4,7,10,13,16-hexa-oxacyclo-octa-deca-ne). When using the midpoints of the coordinating olefin bonds, the overall geometry of the coordination sphere around iron can be best described as distorted tetra-hedral. The naphthalene fold angle between the plane of the iron-coordinating butadiene unit and the plane containing the exo-benzene moiety is 19.2 (1)°.

  4. Cross-sectional study of factors associated with community health centre use in a recently urbanised community in Chengdu, China.

    PubMed

    Liu, Danping; Meng, Hongdao; Dobbs, Debra; Conner, Kyaien O; Hyer, Kathryn; Li, Ningxiu; Ren, Xiaohui; Gao, Bo

    2017-06-08

    Public investment in community health centres (CHCs) has been increasing as a response to rapid urbanisation in China. The objectives of this study were: (1) to examine factors associated with CHC use among residents from a recently urbanised community in western China and (2) to describe satisfaction with CHC among users. Cross-sectional design. A community recently converted to urban status with a newly constructed CHC in Southwest China. A random sample of 2259 adults in the Hezuo community in Chengdu, China, completed the survey in 2013. Trained staff interviewed study participants in their homes using structured questionnaires. The survey included questions regarding sociodemographics, health status, access to and usage of healthcare, health behaviours and CHC use. The Andersen's behavioural model of health service use was used to guide multivariable logistic regression modelling in identifying predisposing, enabling and need factors associated with the likelihood of using CHC. Descriptive statistics were used to describe residents' satisfaction with the CHC. A total of 71.8% of the respondents reported using the CHC during the past year. Factors influencing adults' CHC use included: gender, marital status, education level and knowledge of one's blood pressure (predisposing factors); annual household per capita income and walking time to the CHC (enabling factors) and self-rated health as well as physical activities (need factors). CHC users reported modest satisfaction across various aspects of the CHC. Neighbourhood CHC in urban areas provides important services to these residents living in a recently urbanised community. All three categories of factors in the Andersen model help explain the likelihood of CHC use. There is much room for improvement in CHC to enhance customer satisfaction. Future research is needed to improve access to CHCs and promote their use in urbanised populations with low to modest education. © Article author(s) (or their employer

  5. Topobathymetric LiDAR point cloud processing and landform classification in a tidal environment

    NASA Astrophysics Data System (ADS)

    Skovgaard Andersen, Mikkel; Al-Hamdani, Zyad; Steinbacher, Frank; Rolighed Larsen, Laurids; Brandbyge Ernstsen, Verner

    2017-04-01

    Historically it has been difficult to create high resolution Digital Elevation Models (DEMs) in land-water transition zones due to shallow water depth and often challenging environmental conditions. This gap of information has been reflected as a "white ribbon" with no data in the land-water transition zone. In recent years, the technology of airborne topobathymetric Light Detection and Ranging (LiDAR) has proven capable of filling out the gap by simultaneously capturing topographic and bathymetric elevation information, using only a single green laser. We collected green LiDAR point cloud data in the Knudedyb tidal inlet system in the Danish Wadden Sea in spring 2014. Creating a DEM from a point cloud requires the general processing steps of data filtering, water surface detection and refraction correction. However, there is no transparent and reproducible method for processing green LiDAR data into a DEM, specifically regarding the procedure of water surface detection and modelling. We developed a step-by-step procedure for creating a DEM from raw green LiDAR point cloud data, including a procedure for making a Digital Water Surface Model (DWSM) (see Andersen et al., 2017). Two different classification analyses were applied to the high resolution DEM: A geomorphometric and a morphological classification, respectively. The classification methods were originally developed for a small test area; but in this work, we have used the classification methods to classify the complete Knudedyb tidal inlet system. References Andersen MS, Gergely Á, Al-Hamdani Z, Steinbacher F, Larsen LR, Ernstsen VB (2017). Processing and performance of topobathymetric lidar data for geomorphometric and morphological classification in a high-energy tidal environment. Hydrol. Earth Syst. Sci., 21: 43-63, doi:10.5194/hess-21-43-2017. Acknowledgements This work was funded by the Danish Council for Independent Research | Natural Sciences through the project "Process-based understanding and

  6. Is modern climate variability reflected in compund specific hydrogen isotope ratios of sedimentary biomarkers?

    NASA Astrophysics Data System (ADS)

    Sachse, D.; Radke, J.; Gleixner, G.

    2003-04-01

    Compound specific hydrogen isotope ratios are emerging as a new palaeoclimatic and palaeohydrological proxy. First reconstructions of palaeoclimate using D/H ratios from n-alkanes are available (Andersen et al. 2001, Sauer et al. 2001, Sachse et al. 2003). However, a systematic approach comparing recent sedimentary biomarkers with climate data is still lacking. We are establishing an ecosystem study of small, ground water fed lakes with known limnology. Nearly all lakes are close to a long-term climate-monitoring site (CARBOEUROPE flux tower site, IAEA precipitation monitoring) delivering ecophysiological and climatic data as temperature, precipitation, evapotranspiration etc. Water, primary biomass, plant, soil and sediment were sampled from lakes and the surrounding ecosystem along a climatic and isotopic gradient in meteoric waters from northern Finland (deltaD: -130 permil vs. VSMOW) to southern Italy (deltaD: -30 permil vs. VSMOW, IAEA 2001). Biomarkers were extracted from the samples to test if climatic variability is reflected in their D/H ratios. First results of the factors influencing the hydrogen isotope composition of sedimentary biomarkers and their use as palaeoclimatic and palaeohydrological proxy will be presented. Andersen N, Paul HA, Bernasconi SM, McKenzie JA, Behrens A, Schaeffer P, Albrecht P (2001) Large and rapid climate variability during the Messinian salinity crisis: Evidence from deuterium concentrations of individual biomarkers. Geology 29:799-802 IAEA (2001) GNIP Maps and Animations. International Atomic Energy Agency, Vienna. Accessible at http://isohis.iaea.org Sachse D, Radke J, Gaupp R, Schwark L, Lüniger G, Gleixner G (2003) Reconstruction of palaeohydrological conditions in a lagoon during the 2nd Zechstein cycle through simultaneous use of deltaD values of individual n-alkanes and delta18O and delta13C values of carbonates. International Journal of Earth Sciences, submitted Sauer PE, Eglington TI, Hayes JM, Schimmelman A

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Olivares, Stefano

    We investigate the performance of a selective cloning machine based on linear optical elements and Gaussian measurements, which allows one to clone at will one of the two incoming input states. This machine is a complete generalization of a 1{yields}2 cloning scheme demonstrated by Andersen et al. [Phys. Rev. Lett. 94, 240503 (2005)]. The input-output fidelity is studied for a generic Gaussian input state, and the effect of nonunit quantum efficiency is also taken into account. We show that, if the states to be cloned are squeezed states with known squeezing parameter, then the fidelity can be enhanced using amore » third suitable squeezed state during the final stage of the cloning process. A binary communication protocol based on the selective cloning machine is also discussed.« less

  8. Creating a Space for Acknowledgment and Generativity in Reflective Group Supervision.

    PubMed

    Paré, David

    2016-06-01

    Small group supervision is a powerful venue for generative conversations because of the multiplicity of perspectives available and the potential for an appreciative audience to a practitioner's work. At the same time, the well-intentioned reflections by a few practitioners in a room can inadvertently duplicate normative discourses that circulate in the wider culture and the profession. This article explores the use of narrative practices for benefiting from the advantages of group supervision while mindful of the vulnerability that comes with sharing one's work among colleagues. The reflective group supervision processes described were modified from the work of Tom Andersen and Michael White to provide a venue that encourages the creative multiplicity of group conversation while discouraging unhelpful discourses which constrain generative conversation. © 2016 Family Process Institute.

  9. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klemt, M.

    Relative oscillator strengths of 139 Til lines were determined from emission measurements of a three chamber electric arc burning in an argon atmosphere. Introducing a small admixture of titanium chloride into the center of the arc, spectra of titanium could be observed end-on with no self-absorption and no selfreversal of the measured lines. The relative oscillator strengths were obtained from the Til line intensities and the measured arc temperature. Using absolute oscillator strengths of three resonance lines which had been measured by Reinke (1967), and several life time measurements from Hese (1970), Witt et al. (1971) and Andersen and Sorensenmore » (1972), the relative oscillator strengths were converted to an absolute scale. The accuracy of these absolute values is in the range of 20% to 40%. (auth)« less

  10. The relational self: an interpersonal social-cognitive theory.

    PubMed

    Andersen, Susan M; Chen, Serena

    2002-10-01

    The authors propose an interpersonal social-cognitive theory of the self and personality, the relational self, in which knowledge about the self is linked with knowledge about significant others, and each linkage embodies a self-other relationship. Mental representations of significant others are activated and used in interpersonal encounters in the social-cognitive phenomenon of transference (S. M. Andersen & N. S. Glassman, 1996), and this evokes the relational self. Variability in relational selves depends on interpersonal contextual cues, whereas stability derives from the chronic accessibility of significant-other representations. Relational selves function in if-then terms (W. Mischel & Y. Shoda, 1995), in which ifs are situations triggering transference, and thens are relational selves. An individual's repertoire of relational selves is a source of interpersonal patterns involving affect, motivation, self-evaluation, and self-regulation.

  11. The Lowe-Andersen thermostat as an alternative to the dissipative particle dynamics in the mesoscopic simulation of entangled polymers.

    PubMed

    Khani, Shaghayegh; Yamanoi, Mikio; Maia, Joao

    2013-05-07

    Dissipative Particle Dynamics (DPD) has shown a great potential in studying the dynamics and rheological properties of soft matter; however, it is associated with deficiencies in describing the characteristics of entangled polymer melts. DPD deficiencies are usually correlated to the time integrating method and the unphysical bond crossings due to utilization of soft potentials. One shortcoming of DPD thermostat is the inability to produce real values of Schmidt number for fluids. In order to overcome this, an alternative Lowe-Anderson (LA) method, which successfully stabilizes the temperature, is used in the present work. Additionally, a segmental repulsive potential was introduced to avoid unphysical bond crossings. The performance of the method in simulating polymer systems is discussed by monitoring the static and dynamic characteristics of polymer chains and the results from the LA method are compared to standard DPD simulations. The performance of the model is evaluated on capturing the main shear flow properties of entangled polymer systems. Finally the linear and nonlinear viscoelastic properties of such systems are discussed.

  12. ESTCP Munitions Response Live Site Demonstrations Southwest Proving Ground, Arkansas Andersen Air Force Base, Guam Cost and Performance Report

    DTIC Science & Technology

    2017-09-01

    CANNOT BE ANALYZED ....... 17  7.0  COST BENEFIT ANALYSIS...20  7.3  COST BENEFIT ...sites and assess the performance and cost benefits of implementing AGC technologies. OBJECTIVES OF THE DEMONSTRATION The demonstrations were

  13. Thermostating extended Lagrangian Born-Oppenheimer molecular dynamics.

    PubMed

    Martínez, Enrique; Cawkwell, Marc J; Voter, Arthur F; Niklasson, Anders M N

    2015-04-21

    Extended Lagrangian Born-Oppenheimer molecular dynamics is developed and analyzed for applications in canonical (NVT) simulations. Three different approaches are considered: the Nosé and Andersen thermostats and Langevin dynamics. We have tested the temperature distribution under different conditions of self-consistent field (SCF) convergence and time step and compared the results to analytical predictions. We find that the simulations based on the extended Lagrangian Born-Oppenheimer framework provide accurate canonical distributions even under approximate SCF convergence, often requiring only a single diagonalization per time step, whereas regular Born-Oppenheimer formulations exhibit unphysical fluctuations unless a sufficiently high degree of convergence is reached at each time step. The thermostated extended Lagrangian framework thus offers an accurate approach to sample processes in the canonical ensemble at a fraction of the computational cost of regular Born-Oppenheimer molecular dynamics simulations.

  14. Particle size distribution of airborne Aspergillus fumigatus spores emitted from compost using membrane filtration

    NASA Astrophysics Data System (ADS)

    Deacon, L. J.; Pankhurst, L. J.; Drew, G. H.; Hayes, E. T.; Jackson, S.; Longhurst, P. J.; Longhurst, J. W. S.; Liu, J.; Pollard, S. J. T.; Tyrrel, S. F.

    Information on the particle size distribution of bioaerosols emitted from open air composting operations is valuable in evaluating potential health impacts and is a requirement for improved dispersion simulation modelling. The membrane filter method was used to study the particle size distribution of Aspergillus fumigatus spores in air 50 m downwind of a green waste compost screening operation at a commercial facility. The highest concentrations (approximately 8 × 10 4 CFU m -3) of culturable spores were found on filters with pore diameters in the range 1-2 μm which suggests that the majority of spores are emitted as single cells. The findings were compared to published data collected using an Andersen sampler. Results were significantly correlated ( p < 0.01) indicating that the two methods are directly comparable across all particles sizes for Aspergillus spores.

  15. [Utilization of dental services for children: a review of the influencing factors and the possible improvements].

    PubMed

    Cheng, M L; Si, Y

    2017-05-09

    It has been reported that children's oral health conditions are correlated with their attendance to dental health services. Evaluating the influencing factors of utilization of dental services for children may give ways to improve the services per se, and furtherly the children's oral health. The present review retrieved and summarized domestic and foreign studies on the utilization of oral health services for children based on the Andersen behavior model. It was concluded that the utilization of dental services for children was affected by demographic characteristics, social structure, health belief, family factors, community factors and perceived/evaluated needs. To improve the utilization of dental services for children, effort should be made by means of changing caregivers' health belief, developing oral health insurance system, setting up regular oral health resources and increasing the financial support for oral health services by government.

  16. 1995 mask industry quality assessment

    NASA Astrophysics Data System (ADS)

    Bishop, Chris; Strott, Al

    1995-12-01

    The third annual mask industry assessment will again survey various industry companies for key performance measurements in the areas of quality and delivery. This year's assessment is enhanced to include the area of safety and further breakdown of the data into 5-inch vs. 6- inch. The data compiled includes shipments, customer return rate, customer return reason, performance to schedule, plate survival yield, and throughput time (TPT) from 1988 through Q2, 1995. Contributor identities remain protected by utilizing Arthur Andersen & Company to ensure participant confidentiality. Participation in the past included representation of over 75% of the total merchant and captive mask volume in the United States. This year's assessment is expected to result in expanded participation by again inviting all mask suppliers domestically to participate as well as an impact from inviting international suppliers to participate.

  17. Is there a tripeptidyl peptidase in the renal brush-border membrane?

    PubMed Central

    Kenny, A J; Ingram, J

    1988-01-01

    A recent claim that the renal brush border contains a tripeptidyl peptidase [Andersen & McDonald (1987) Am. J. Physiol. 253, F649-F655] was examined. In a fluorescent assay, the hydrolysis of Gly-Pro-Met-2-naphthylamide (-NH-Nap) and Gly-Pro-Leu-NH-Nap by pig kidney microvilli was strongly inhibited by amastatin or di-isopropyl phosphorofluoridate (inhibitors of aminopeptidases and dipeptidyl peptidase IV). The products formed were shown to be Gly-Pro and Met-NH-Nap (or Leu-NH-Nap) and free 2-naphthylamine. Specific antibodies to pig and rat aminopeptidase N abolished the apparent tripeptidyl peptidase activity. We conclude that these substrates are hydrolysed by the sequential attack of dipeptidyl peptidase IV and aminopeptidase N and that pig and rat brush borders lack a detectable tripeptidyl peptidase. Images Fig. 1. PMID:3058122

  18. Theory of Charge Transport in Organic Crystals: Lessons from the Past and Prospects for the Future

    NASA Astrophysics Data System (ADS)

    Kenkre, V. M.

    2002-03-01

    Interest in fundamental issues regarding charge transport in organic materials shifted in the early 80's from the field of crystals to the field of disordered systems after polaron theories[1,2] were successfully applied[2] to what was suspected to be a mobility transition in naphthalene[3]. Recent experiments on pentacene[4] have been responsible for a reversal of the shift: there is now a revival of interest in crystals particularly in basic questions regarding electron-phonon interactions, polaron formation, the nature of charge carriers, and the issue of band versus hopping transport. High magnitudes of the new mobilities appear to imply large free carrier bandwidths which have led some to conjecture that band (rather than hopping) transport is characteristic of pentacene[5]. And yet, pentacene experiments show an unmistakable rise in the mobility at higher temperature, a rise that seems to signal polaronic behavior. Added to this fascinating mélange of facts are clear velocity saturation effects[6] observed in pentacene[4] along with some cavalier interpretation attempts of those non-Ohmic effects. The purpose of the talk is to attempt to address basic issues raised by these observations. 1. R. Silbey and R. W. Munn, J. Chem. Phys. 72, 2763 (1980). 2. V. M. Kenkre, John D. Andersen, D.H. Dunlap, and C.B. Duke, Phys. Rev. Lett. 62, 1165 (1989); see also M. Pope and C. E. Swenberg, Electronic Processes in Organic Crystals and Polymers, 2nd ed. (Oxford Univ Press, New Yourk 1999), p. 968. 3. L. B. Schein, C. B. Duke, and A.R. McGhie, Phys. Rev. Lett. 40, 197 (1978); C. B. Duke and L. B. Schein, Physics Today 33, 42 (1980). 4. J. H. Schoen, C. Kloc, and B. Batlogg, Phys. Rev. Lett. 86, 3843 (2001); Phys. Rev. B63, 245201 (2001). 5. Note, however, a recent demonstration against bare band descriptions in pentacene provided by J. D. Andersen, L. Giuggioli, and V. M. Kenkre, Phys. Rev. B, submitted. 6. V. M. Kenkre and P. E. Parris, Phys. Rev. B, submitted; P. E

  19. Applying Earth Observation Data to agriculture risk management: a public-private collaboration to develop drought maps in North-East China

    NASA Astrophysics Data System (ADS)

    Surminski, S.; Holt Andersen, B.; Hohl, R.; Andersen, S.

    2012-04-01

    . This paper concludes by exploring the potential of replicating such a partnership approach to climate risk assessment in other regions. Authors of the paper: Surminski, Swenja (London School of Economics); Holt Andersen, Birgitte (CWare); Hohl, Roman (Swiss Re); Andersen, Søren (COWI)

  20. Anhydrite precipitation in seafloor hydrothermal systems

    NASA Astrophysics Data System (ADS)

    Theissen-Krah, Sonja; Rüpke, Lars H.

    2016-04-01

    The composition and metal concentration of hydrothermal fluids venting at the seafloor is strongly temperature-dependent and fluids above 300°C are required to transport metals to the seafloor (Hannington et al. 2010). Ore-forming hydrothermal systems and high temperature vents in general are often associated with faults and fracture zones, i.e. zones of enhanced permeabilities that act as channels for the uprising hydrothermal fluid (Heinrich & Candela, 2014). Previous numerical models (Jupp and Schultz, 2000; Andersen et al. 2015) however have shown that high permeabilities tend to decrease fluid flow temperatures due to mixing with cold seawater and the resulting high fluid fluxes that lead to short residence times of the fluid near the heat source. A possible mechanism to reduce the permeability and thereby to focus high temperature fluid flow are mineral precipitation reactions that clog the pore space. Anhydrite for example precipitates from seawater if it is heated to temperatures above ~150°C or due to mixing of seawater with hydrothermal fluids that usually have high Calcium concentrations. We have implemented anhydrite reactions (precipitation and dissolution) in our finite element numerical models of hydrothermal circulation. The initial results show that the precipitation of anhydrite efficiently alters the permeability field, which affects the hydrothermal flow field as well as the resulting vent temperatures. C. Andersen et al. (2015), Fault geometry and permeability contrast control vent temperatures at the Logatchev 1 hydrothermal field, Mid-Atlantic Ridge, Geology, 43(1), 51-54. M. D. Hannington et al. (2010), Modern Sea-Floor Massive Sulfides and Base Metal Resources: Toward an Estimate of Global Sea-Floor Massive Sulfide Potential, in The Challenge of Finding New Mineral Resources: Global Metallogeny, Innovative Exploration, and New Discoveries, edited by R. J. Goldfarb, E. E. Marsh and T. Monecke, pp. 317-338, Society of Economic Geologists

  1. Adapting the Abbreviated Impactor Measurement (AIM) concept to make appropriate inhaler aerosol measurements to compare with clinical data: a scoping study with the "Alberta" idealized throat (AIT) inlet.

    PubMed

    Mitchell, Jolyon; Copley, Mark; Sizer, Yvonne; Russell, Theresa; Solomon, Derek

    2012-08-01

    The Abbreviated Impactor Measurement (AIM) concept simplifies determination of aerodynamic size metrics for inhaler quality control testing. A similar approach is needed to compare in vitro particle size distribution metrics with human respiratory tract (HRT) deposition. An abbreviated impactor based on the Andersen eight-stage cascade impactor (ACI) was developed having two size-fractionating stages with cut-points at 4.7 and 1.1 μm aerodynamic diameter at 28.3 L/min, to distinguish between coarse (CPM), fine (FPM), and extra-fine (EPM) mass fractions likely to deposit in the oropharynx, airways of the lungs, or be exhaled, respectively. In vitro data were determined for pressurized metered dose inhaler (pMDI)-delivered salbutamol (100 μg/actuation ex valve) with an "Alberta" idealized adult upper airway (throat) inlet (AIM-pHRT). Corresponding benchmark data for a full resolution Andersen eight-stage cascade impactor with "Alberta" idealized throat (ACI-AIT) and ACI-Ph.Eur./USP inlet were obtained with the same product. Mass recoveries (μg/actuation; mean ± SD) were equivalent at 100.5 ± 0.7; 97.2 ± 4.9 and 101.5 ± 9.5 for the AIM-pHRT, ACI-AIT, and ACI-Ph.Eur./USP induction port, respectively [one-way analysis of variance (ANOVA), p=0.64]. Corresponding values of CPM were 59.2 ± 4.2; 58.4 ± 2.4, and 65.6 ± 5.8; the AIT captured larger particles more efficiently than the Ph.Eur./USP induction port, so that less large particle mass was apparent in the upper stages of the ACI-AIT (p ≤ 0.037). Equivalent values of FPM were similar regardless of inlet/abbreviation at 41.3 ± 4.2; 38.7 ± 3.0, and 35.9 ± 3.8 (p=0.054), and EPM measures (1.7 ± 0.3; 2.0 ± 0.5; 2.1 ± 0.3) were also comparable (p=0.32). The AIT inlet significantly increased the capture of the coarse fraction compared with that collected by the Ph.Eur./USP induction port. Measures obtained using the AIM-pHRT apparatus were comparable with those obtained with the ACI-AIT.

  2. An explanatory model for state Medicaid per capita prescription drug expenditures.

    PubMed

    Roy, Sanjoy; Madhavan, S Suresh

    2012-01-01

    Rising prescription drug expenditure is a growing concern for publicly funded drug benefit programs like Medicaid. To be able to contain drug expenditures in Medicaid, it is important that cause(s) for such increases are identified. This study attempts to establish an explanatory model for Medicaid prescription drugs expenditure based on the impacts of key influencers/predictors identified using a comprehensive framework of drug utilization. A modified Andersen's behavior model of health services utilization is employed to identify potential determinants of pharmaceutical expenditures in state Medicaid programs. Level of federal matching funds, access to primary care, severity of diseases, unemployment, and education levels were found to be key influencers of Medicaid prescription drug expenditure. Increases in all, except education levels, were found to result in increases in drug expenditures. Findings from this study could better inform intervention policies and cost-containment strategies for state Medicaid drug benefit programs.

  3. African American Female Offender's Use of Alternative and Traditional Health Services After Re-Entry: Examining the Behavioral Model for Vulnerable Populations.

    PubMed

    Oser, Carrie B; Bunting, Amanda M; Pullen, Erin; Stevens-Watkins, Danelle

    2016-01-01

    This is the first known study to use the Gelberg-Andersen Behavioral Model for Vulnerable Populations to predict African American women's use of three types of health services (alternative, hospitalization, and ambulatory) in the 18 months after release from prison. In the multivariate models, the most robust predictors of all three types of service utilization were in the vulnerable theoretical domains. Alternative health services were predicted by ethnic community membership, higher religiosity, and HIV/HCV. Hospitalizations were predicted by the lack of barriers to health care and disability. Ambulatory office visits were predicted by more experiences of gendered racism, a greater number of physical health problems, and HIV/HCV. Findings highlight the importance of cultural factors and HIV/HCV in obtaining both alternative and formal health care during community re-entry. Clinicians and policymakers should consider the salient role that the vulnerable domain plays in offender's accessing health services.

  4. Hard sphere perturbation theory for fluids with soft-repulsive-core potentials

    NASA Astrophysics Data System (ADS)

    Ben-Amotz, Dor; Stell, George

    2004-03-01

    The thermodynamic properties of fluids with very soft repulsive-core potentials, resembling those of some liquid metals, are predicted with unprecedented accuracy using a new first-order thermodynamic perturbation theory. This theory is an extension of Mansoori-Canfield/Rasaiah-Stell (MCRS) perturbation theory, obtained by including a configuration integral correction recently identified by Mon, who evaluated it by computer simulation. In this work we derive an analytic expression for Mon's correction in terms of the radial distribution function of the soft-core fluid, g0(r), approximated using Lado's self-consistent extension of Weeks-Chandler-Andersen (WCA) theory. Comparisons with WCA and MCRS predictions show that our new extended-MCRS theory outperforms other first-order theories when applied to fluids with very soft inverse-power potentials (n⩽6), and predicts free energies that are within 0.3kT of simulation results up to the fluid freezing point.

  5. Intraday return inefficiency and long memory in the volatilities of forex markets and the role of trading volume

    NASA Astrophysics Data System (ADS)

    Shahzad, Syed Jawad Hussain; Hernandez, Jose Areola; Hanif, Waqas; Kayani, Ghulam Mujtaba

    2018-09-01

    We investigate the dynamics of efficiency and long memory, and the impact of trading volume on the efficiency of returns and volatilities of four major traded currencies, namely, the EUR, GBP, CHF and JPY. We do so by implementing full sample and rolling window multifractal detrended fluctuation analysis (MF-DFA) and a quantile-on-quantile (QQ) approach. This paper sheds new light by employing high frequency (5-min interval) data spanning from Jan 1, 2007 to Dec 31, 2016. Realized volatilities are estimated using Andersen et al.'s (2001) measure, while the QQ method employed is drawn from Sim and Zhou (2015). We find evidence of higher efficiency levels in the JPY and CHF currency markets. The impact of trading volume on efficiency is only significant for the JPY and CHF currencies. The GBP currency appears to be the least efficient, followed by the EUR. Implications of the results are discussed.

  6. Use of annual physical examinations by aging Chinese Canadians.

    PubMed

    Lai, Daniel W L; Kalyniak, Sonya

    2005-10-01

    This study identified predictors of use of annual physical examination by aging Chinese Canadians. Data were collected from a random sample of 2,272 Chinese Canadians aged 55 and older. Based on the Andersen-Newman service utilization framework, hierarchical logistic regression analysis was used to examine the predictors of annual physical examination use. Predicting factors of annual physical health examination use were marital status, gender, length of residency in Canada, Chinese ethnic identity, social support, number of illnesses, dependency in instrumental activities of daily living (IADL), and depressive symptoms. Findings showed importance in targeting identified groups for preventive health education. Strengthened ethnic identity may serve to enhance one's social support network, which in turn facilitates the use of annual physical examinations. There may be awareness within the Chinese cultural network that builds education and attentiveness to preventive health care. The misconceptions about annual physical examinations were also discussed.

  7. Comparative Effectiveness Research and Children With Cerebral Palsy: Identifying a Conceptual Framework and Specifying Measures.

    PubMed

    Gannotti, Mary E; Law, Mary; Bailes, Amy F; OʼNeil, Margaret E; Williams, Uzma; DiRezze, Briano

    2016-01-01

    A step toward advancing research about rehabilitation service associated with positive outcomes for children with cerebral palsy is consensus about a conceptual framework and measures. A Delphi process was used to establish consensus among clinicians and researchers in North America. Directors of large pediatric rehabilitation centers, clinicians from large hospitals, and researchers with expertise in outcomes participated (N = 18). Andersen's model of health care utilization framed outcomes: consumer satisfaction, activity, participation, quality of life, and pain. Measures agreed upon included Participation and Environment Measure for Children and Youth, Measure of Processes of Care, PEDI-CAT, KIDSCREEN-10, PROMIS Pediatric Pain Interference Scale, Visual Analog Scale for pain intensity, PROMIS Global Health Short Form, Family Environment Scale, Family Support Scale, and functional classification levels for gross motor, manual ability, and communication. Universal forms for documenting service use are needed. Findings inform clinicians and researchers concerned with outcome assessment.

  8. Treatment barriers identified by substance abusers assessed at a centralized intake unit.

    PubMed

    Rapp, Richard C; Xu, Jiangmin; Carr, Carey A; Lane, D Tim; Wang, Jichuan; Carlson, Robert

    2006-04-01

    The 59-item Barriers to Treatment Inventory (BTI) was administered to 312 substance abusers at a centralized intake unit following assessment but before treatment entry to assess their views on barriers to treatment. Factor analysis identified 25 items in 7 well-defined latent constructs: Absence of Problem, Negative Social Support, Fear of Treatment, Privacy Concerns, Time Conflict, Poor Treatment Availability, and Admission Difficulty. The factorial structure of the barriers is consistent with the findings of other studies that asked substance abusers about barriers to treatment and is conceptually compatible with Andersen's model of health care utilization. Factors were moderately to highly correlated, suggesting that they interact with one another. Selected characteristics were generally not predictive of barrier factors. Overall, results indicate that the BTI has good content validity and is a reliable instrument for assessing barriers to drug treatment. The potential utility of the BTI in assessment settings is discussed.

  9. Mask industry quality assessment

    NASA Astrophysics Data System (ADS)

    Strott, Al; Bassist, Larry

    1994-12-01

    Product quality and timely delivery are two of the most important parameters in determining the success of a mask manufacturing facility. Because of the sensitivity of this data, very little was known about industry performance in these areas until an assessment was authored and presented at the 1993 BACUS Symposium by Larry Regis of Intel Corporation, Neil Paulsen of Intel Corporation, and James A. Reynolds of Reynolds Consulting. This data has been updated and will be published and presented at this year's BACUS Symposium. Contributor identities will again remain protected by utilizing Arthur Andersen & Company to compile the submittals. Participation was consistent with last year's representation of over 75% of the total merchant and captive mask volume in the United States. The data compiled includes shipments, customer return rate, customer return reasons from 1988 through Q2, 1994, performance to schedule, plate survival yield, and throughput time (TPT).

  10. Ambulatory surgery centers best practices for the 90s.

    PubMed

    Hoover, J A

    1994-05-01

    Outpatient surgery will be the driving force in the continued growth of ambulatory care in the 1990s. Providing efficient, high-quality ambulatory surgical services should therefore be a priority among healthcare providers. Arthur Andersen conducted a survey to discover best practices in ambulatory surgical service. General success characteristics of best performers were business-focused relationships with physicians, the use of clinical protocols, patient convenience, cost management, strong leadership, teamwork, streamlined processes and efficient design. Other important factors included scheduling to maximize OR room use; achieving surgical efficiencies through reduced case pack assembly errors and equipment availability; a focus on cost capture rather than charge capture; sound materiel management practices, such as standardization and vendor teaming; and the appropriate use of automated systems. It is important to evaluate whether the best practices are applicable to your environment and what specific changes to your current processes would be necessary to adopt them.

  11. Thermostating extended Lagrangian Born-Oppenheimer molecular dynamics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martínez, Enrique; Cawkwell, Marc J.; Voter, Arthur F.

    Here, Extended Lagrangian Born-Oppenheimer molecular dynamics is developed and analyzed for applications in canonical (NVT) simulations. Three different approaches are considered: the Nosé and Andersen thermostats and Langevin dynamics. We have tested the temperature distribution under different conditions of self-consistent field (SCF) convergence and time step and compared the results to analytical predictions. We find that the simulations based on the extended Lagrangian Born-Oppenheimer framework provide accurate canonical distributions even under approximate SCF convergence, often requiring only a single diagonalization per time step, whereas regular Born-Oppenheimer formulations exhibit unphysical fluctuations unless a sufficiently high degree of convergence is reached atmore » each time step. Lastly, the thermostated extended Lagrangian framework thus offers an accurate approach to sample processes in the canonical ensemble at a fraction of the computational cost of regular Born-Oppenheimer molecular dynamics simulations.« less

  12. Thermostating extended Lagrangian Born-Oppenheimer molecular dynamics

    DOE PAGES

    Martínez, Enrique; Cawkwell, Marc J.; Voter, Arthur F.; ...

    2015-04-21

    Here, Extended Lagrangian Born-Oppenheimer molecular dynamics is developed and analyzed for applications in canonical (NVT) simulations. Three different approaches are considered: the Nosé and Andersen thermostats and Langevin dynamics. We have tested the temperature distribution under different conditions of self-consistent field (SCF) convergence and time step and compared the results to analytical predictions. We find that the simulations based on the extended Lagrangian Born-Oppenheimer framework provide accurate canonical distributions even under approximate SCF convergence, often requiring only a single diagonalization per time step, whereas regular Born-Oppenheimer formulations exhibit unphysical fluctuations unless a sufficiently high degree of convergence is reached atmore » each time step. Lastly, the thermostated extended Lagrangian framework thus offers an accurate approach to sample processes in the canonical ensemble at a fraction of the computational cost of regular Born-Oppenheimer molecular dynamics simulations.« less

  13. Data on the genome-wide identification of CNL R-genes in Setaria italica (L.) P. Beauv.

    PubMed

    Andersen, Ethan J; Nepal, Madhav P

    2017-08-01

    We report data associated with the identification of 242 disease resistance genes (R-genes) in the genome of Setaria italica as presented in "Genetic diversity of disease resistance genes in foxtail millet ( Setaria italica L.)" (Andersen and Nepal, 2017) [1]. Our data describe the structure and evolution of the Coiled-coil, Nucleotide-binding site, Leucine-rich repeat (CNL) R-genes in foxtail millet. The CNL genes were identified through rigorous extraction and analysis of recently available plant genome sequences using cutting-edge analytical software. Data visualization includes gene structure diagrams, chromosomal syntenic maps, a chromosomal density plot, and a maximum-likelihood phylogenetic tree comparing Sorghum bicolor , Panicum virgatum , Setaria italica , and Arabidopsis thaliana . Compilation of InterProScan annotations, Gene Ontology (GO) annotations, and Basic Local Alignment Search Tool (BLAST) results for the 242 R-genes identified in the foxtail millet genome are also included in tabular format.

  14. TU-E-TOUR-T-00: Exhibit Hall Guided Tours-Microdosimeters for Therapy (Tuesday)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    Tour Leader: Indra Das, NYU Langone Medical Center, New York, NY Tour Guides: Hsui Ai, Indiana University School of Medicine, Indianapolis, IN Aaron Andersen, Indiana University School of Medicine, Indianapolis, IN Olga Volotoskova, NYU Langone Medical Center, New York, NY Participating Vendors: IBA PTW – New York RTI Electronics, Inc. Standard Imaging, Inc. Sun Nuclear Corporation Small fields are increasing used in specialized radiation treatments such as Gammaknife, Cyberknife, Tomotherapy, IMRT, VMAT, SRS and SBRT. Due to small field size electron transport creates lateral electronic disequilibrium and thus dosimetry could be very difficult. Microdetectors are used for small field dosimetrymore » which will be discussed in preface of this tour as below: Understanding small field e.g. meaning and definition of small field IAEA definition and approach Characteristics of microdetectors in terms of perturbation, recombination, correction Suitability of microdetectors in small field dosimetry.« less

  15. Final Environmental Impact Statement Establishment and Operation of an Intelligence, Surveillance, Reconnaissance, and Strike Capability Andersen Air Force Base, Guam

    DTIC Science & Technology

    2007-01-01

    Mariana Fruit Bat Pup Recruitment at Pati Point Colony; • Brown Tree Snake Interdiction and Control; and • Adaptive Management and Ground Track...establishment of a mitigation monitoring plan and adaptive management program. FUTURE ACTIONS As discussed in the Final EIS, the Air Force recognizes that...would initiate modifications to aircraft ground tracks and profiles over sensitive areas through an adaptive management strategy. This adaptive

  16. Attitudes Toward Mental Health Services Among American Indians by Two Age Groups.

    PubMed

    Roh, Soonhee; Brown-Rice, Kathleen A; Lee, Kyoung Hag; Lee, Yeon-Shim; Yee-Melichar, Darlene; Talbot, Elizabeth P

    2015-11-01

    This study examined determinants of attitudes toward mental health services with a sample of American Indian younger-old-adults (aged 50-64, n = 158) and American Indian older-old adults (aged 65 and older, n = 69). Adapting Andersen's behavioral model of healthcare utilization, predisposing factors, mental health needs, and enabling factors were considered as potential predictors. Female and those with higher levels of social support tend to report more positive attitudes toward mental health services. Culture-influenced personal belief was associated with negative attitudes toward mental health services among American Indian younger-old -adults. Age and higher chronic medical conditions were significantly related to negative attitudes toward mental health services. Health insurance was positively associated with positive attitudes toward mental health services in the American Indian older-old adults. Findings indicate that practitioners should engage how culture, social support, and chronic conditions influence the response to mental health needs when working with older American Indians.

  17. Equity of access to primary care among older adults in Incheon, South Korea.

    PubMed

    Park, Ju Moon

    2012-11-01

    The present study examines the extent to which equity in the use of physician services for the elderly has been achieved in Incheon, Korea. It is based on the Aday and Andersen Access Framework. The results indicate that a universal health insurance system has not yielded a fully equitable distribution of services. The limitation of benefit coverage as well as high out-of-pocket payment can be a barrier to health care utilization, which results in inequity and differential medical care utilization between subgroups of older adults. Health policy reforms in South Korea must continue to concentrate on extending insurance coverage to the uninsured and establishing a financially separate insurance system for poor older adults. In addition, further research is needed to identify the nonfinancial barriers that persist for certain demographic subgroups, that is, those 80 years and older, men, those who lack a social network, and those who have no religion.

  18. Glass transition temperature of polymer nano-composites with polymer and filler interactions

    NASA Astrophysics Data System (ADS)

    Hagita, Katsumi; Takano, Hiroshi; Doi, Masao; Morita, Hiroshi

    2012-02-01

    We systematically studied versatile coarse-grained model (bead spring model) to describe filled polymer nano-composites for coarse-grained (Kremer-Grest model) molecular dynamics simulations. This model consists of long polymers, crosslink, and fillers. We used the hollow structure as the filler to describe rigid spherical fillers with small computing costs. Our filler model consists of surface particles of icosahedra fullerene structure C320 and a repulsive force from the center of the filler is applied to the surface particles in order to make a sphere and rigid. The filler's diameter is 12 times of beads of the polymers. As the first test of our model, we study temperature dependence of volumes of periodic boundary conditions under constant pressures through NPT constant Andersen algorithm. It is found that Glass transition temperature (Tg) decrease with increasing filler's volume fraction for the case of repulsive interaction between polymer and fillers and Tg weakly increase for attractive interaction.

  19. The determinants of long-term care utilization and equity of access to care among older adults in Dong-Ku of Incheon Metropolitan city, South Korea.

    PubMed

    Park, J M

    2005-01-01

    Under the current health care system, around three percent of the elderly remain uninsured. Based on the 2003 Dong-Ku Health Status Survey and the Aday and Andersen Access Framework, the present study examined the social and behavioral determinants of long-term care utilization and the extent to which equity in the use of long-term care services for the elderly has been achieved. The results indicate that universal health insurance system has not yielded a fully equitable distribution of services. Type of coverage and resource availability do not remain predictors of long-term care utilization. The data suggest that a universal health insurance system exists in South Korea with significant access problems for the population without insurance. Access differences also arise from obstacles in expanding the scope and level of plan benefits due to financial disparity among insurers. Health policy reforms must continue to concentrate on extending insurance coverage to the uninsured and establishing long-term insurance system for the elderly.

  20. HPV Literacy: The Role of English Proficiency in Korean American Immigrant Women.

    PubMed

    Lee, Hee Yun; Choi, Y Joon; Yoon, Young Ji; Oh, Jennifer

    2018-06-01

    Although Korean American women have one of the highest cervical cancer incidence and mortality rates among all Asian American and non-Hispanic White women, they are less likely to receive the human papillomavirus (HPV) vaccine to prevent cervical cancer. This study aimed to examine Korean American women's HPV literacy and factors related to HPV literacy to identify targeted intervention strategies. A quota sampling strategy was used to recruit 243 Korean American women aged 19-85 years in the Atlanta, Georgia, metropolitan area. Multiple linear regression analysis was conducted using Andersen's Behavioral Model of Health Services Use to examine factors associated with HPV literacy. HPV literacy of Korean American immigrant women was moderate, and knowledge about HPV detection items was particularly low. Age was the only predisposing factor that had a significantly negative association with HPV literacy, whereas education level and English proficiency had a significant positive relationship with HPV literacy. Health status as a need factor was significantly positively associated with HPV literacy.

  1. Environmental assessment of an enhanced-oil-recovery steam generator equipped with a low-NOx burner. Volume 2. Data supplement. Final report, January 1984-January 1985

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Castaldini, C.; Waterland, L.R.; Lips, H.I.

    1986-02-01

    The report is a compendium of detailed test sampling and analysis data obtained in field tests of an enhanced-oil-recovery steam generator (EOR steamer) equipped with a MHI PM low-NOx crude oil burner. Test data reported include equipment calibration records, steamer operating data, and complete flue-gas emission results. Flue-gas emission measurements included continuous monitoring for criteria pollutants; onsite gas chromatography (GC) for volatile hydrocarbons (Cl-C6); Methods 5/8 sampling for particulate and SO/sub 2/ and SO/sub 3/ emissions; source assessment sampling system (SASS) for total organics in two boiling-point ranges (100 to 300 C and greater than or equal to 300 C),more » organic compound category information using infrared spectrometry (IR), and specific quantitation of the semivolatile organic priority pollutants using gas chromatography/mass spectrometry (GC/MS); Andersen impactor train measurements of emitted particle-size distribution; and N/sub 2/O emissions by gas chromatography/electron-capture detector (GC/ECD).« less

  2. African American Female Offender’s Use of Alternative and Traditional Health Services After Re-Entry: Examining the Behavioral Model for Vulnerable Populations

    PubMed Central

    Oser, Carrie B.; Bunting, Amanda M.; Pullen, Erin; Stevens-Watkins, Danelle

    2016-01-01

    This is the first known study to use the Gelberg-Andersen Behavioral Model for Vulnerable Populations to predict African American women’s use of three types of health services (alternative, hospitalization, and ambulatory) in the 18 months after release from prison. In the multivariate models, the most robust predictors of all three types of service utilization were in the vulnerable theoretical domains. Alternative health services were predicted by ethnic community membership, higher religiosity, and HIV/HCV. Hospitalizations were predicted by the lack of barriers to health care and disability. Ambulatory office visits were predicted by more experiences of gendered racism, a greater number of physical health problems, and HIV/HCV. Findings highlight the importance of cultural factors and HIV/HCV in obtaining both alternative and formal health care during community re-entry. Clinicians and policy makers should consider the salient role that the vulnerable domain plays in offender’s accessing health services. PMID:27133515

  3. On-target digestion of collected bacteria for MALDI mass spectrometry.

    PubMed

    Dugas, Alton J; Murray, Kermit K

    2008-10-03

    An on-target protein digestion system was developed for the identification of microorganisms in collected bioaerosols using off-line matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). Bacteria analysis techniques based on MALDI-MS were adapted for use with an orthogonal MALDI quadrupole-time-of-flight mass spectrometer. Bioaerosols were generated using a pneumatic nebulizer and infused into a chamber for sampling. An Andersen N6 single-stage impactor was used to collect the bioaerosols on a MALDI target. On-target digestion was carried out inside temporary mini-wells placed over the impacted samples. The wells served as miniature reactors for proteolysis. Collected test aerosol particles containing the protein cytochrome c and E. coli bacteria were proteolyzed in situ using trypsin or cyanogen bromide. A total of 19 unique proteins were identified for E. coli. Using the TOF-MS spectra of the digested samples, peptide mass mapping was performed using the MASCOT search engine and an iterative search technique.

  4. Is Bare Band Description of Carrier Transport Appropriate in Pentacene?

    NASA Astrophysics Data System (ADS)

    Andersen, John D.; Giuggioli, Luca; Kenkre, V. M.

    2002-03-01

    Experiments on injected charges in pentacene single crystals reveal mobilities typical of inorganic semiconductors and temperature dependence (for T<430K) suggesting bandlike behavior.(J. H. Schon, C. Kloc, and B. Batlogg, Phys. Rev. Lett. 86, 3843 (2001)) Polaronic bands, particularly their narrowing with increasing temperature, were invoked(V. M. Kenkre, John D. Andersen, D.H. Dunlap, and C.B. Duke, Phys. Rev. Lett. 62, 1165 (1989)) in the related naphthalene problem.(L. B. Schein, C. B. Duke, and A.R. McGhie, Phys. Rev. Lett. 40, 197 (1978); L. B. Schein, W. Warta, and N. Karl, Chem. Phys. Lett. 100, 34 (1983)) Because the low temperature mobility values in pentacene suggest moderately large bandwidths, we address two questions. Does a bare wide (effectively infinite) band description work for pentacene for T<400K? And, is a bare finite band description compatible with those data? These questions are answered by modifications of a theory originally constructed for inorganic materials and a newly developed mobility theory.

  5. Visual Search for Motion-Form Conjunctions: Selective Attention to Movement Direction.

    PubMed

    Von Mühlenen, Adrian; Müller, Hermann J

    1999-07-01

    In 2 experiments requiring visual search for conjunctions of motion and form, the authors reinvestigated whether motion-based filtering (e.g., P. McLeod, J. Driver, Z. Dienes, & J. Crisp, 1991) is direction selective and whether cuing of the target direction promotes efficient search performance. In both experiments, the authors varied the number of movement directions in the display and the predictability of the target direction. Search was less efficient when items moved in multiple (2, 3, and 4) directions as compared with just 1 direction. Furthermore, precuing of the target direction facilitated the search, even with "wrap-around" displays, relatively more when items moved in multiple directions. The authors proposed 2 principles to explain that pattern of effects: (a) interference on direction computation between items moving in different directions (e.g., N. Qian & R. A. Andersen, 1994) and (b) selective direction tuning of motion detectors involving a receptive-field contraction (cf. J. Moran & R. Desimone, 1985; S. Treue & J. H. R. Maunsell, 1996).

  6. Factors Associated with Mental Health Service Utilization among Korean American Immigrants

    PubMed Central

    Park, So-Youn; Cho, Sunhee; Park, Yeddi; Bernstein, Kunsook S.; Shin, Jinah K.

    2014-01-01

    This study adapted Andersen's Health Belief Model to examine the predictors of mental health services utilization among Korean American (KA) immigrants. A cross-sectional survey was used to gather data on 363 KA immigrants 18 years and older residing in New York City. Predisposing factors included gender, age, marital status, education, length of stay in the US, and religion; the need factor was depression; and enabling factors included health insurance, English proficiency, income, and perceived need for help. Approximately 8.5 % of participants reported having utilized mental health services, while 23 % reported having depressive symptoms. Shorter duration of residence in the US, lower income, and the presence of perceived need for help were significantly related to use of mental health services. The perceived need for help mediated the relationship between depression and mental health service utilization. Failure to perceive the need for psychological help continues to be a major reason that KA immigrants do not use mental health services. PMID:23417654

  7. Assessing implicit models for nonpolar mean solvation forces: The importance of dispersion and volume terms

    PubMed Central

    Wagoner, Jason A.; Baker, Nathan A.

    2006-01-01

    Continuum solvation models provide appealing alternatives to explicit solvent methods because of their ability to reproduce solvation effects while alleviating the need for expensive sampling. Our previous work has demonstrated that Poisson-Boltzmann methods are capable of faithfully reproducing polar explicit solvent forces for dilute protein systems; however, the popular solvent-accessible surface area model was shown to be incapable of accurately describing nonpolar solvation forces at atomic-length scales. Therefore, alternate continuum methods are needed to reproduce nonpolar interactions at the atomic scale. In the present work, we address this issue by supplementing the solvent-accessible surface area model with additional volume and dispersion integral terms suggested by scaled particle models and Weeks–Chandler–Andersen theory, respectively. This more complete nonpolar implicit solvent model shows very good agreement with explicit solvent results and suggests that, although often overlooked, the inclusion of appropriate dispersion and volume terms are essential for an accurate implicit solvent description of atomic-scale nonpolar forces. PMID:16709675

  8. Predictors of adherence with self-care guidelines among persons with type 2 diabetes: results from a logistic regression tree analysis.

    PubMed

    Yamashita, Takashi; Kart, Cary S; Noe, Douglas A

    2012-12-01

    Type 2 diabetes is known to contribute to health disparities in the U.S. and failure to adhere to recommended self-care behaviors is a contributing factor. Intervention programs face difficulties as a result of patient diversity and limited resources. With data from the 2005 Behavioral Risk Factor Surveillance System, this study employs a logistic regression tree algorithm to identify characteristics of sub-populations with type 2 diabetes according to their reported frequency of adherence to four recommended diabetes self-care behaviors including blood glucose monitoring, foot examination, eye examination and HbA1c testing. Using Andersen's health behavior model, need factors appear to dominate the definition of which sub-groups were at greatest risk for low as well as high adherence. Findings demonstrate the utility of easily interpreted tree diagrams to design specific culturally appropriate intervention programs targeting sub-populations of diabetes patients who need to improve their self-care behaviors. Limitations and contributions of the study are discussed.

  9. Unifying treatments for depression: an application of the Free Energy Principle

    PubMed Central

    Chekroud, Adam M.

    2015-01-01

    Major Depressive Disorder is a debilitating and increasingly prevalent psychiatric condition (Compton et al., 2006; Andersen et al., 2011). At present, its primary treatments are antidepressant medications and psychotherapy. Curiously, although the pharmacological effects of antidepressants manifest within hours, remission of clinical symptoms takes a number of weeks—if at all. Independently, support has grown for an idea—proposed as early as Helmholtz (von Helmholtz, 1924)—that the brain is a prediction machine, holding generative models1 for the purpose of inferring causes of sensory information (Dayan et al., 1995; Rao and Ballard, 1999; Knill and Pouget, 2004; Friston et al., 2006; Friston, 2010). If the brain does indeed represent a collection of beliefs about the causal structure of the world, then the depressed phenotype may emerge from a collection of depressive beliefs. These beliefs are modified gradually through successive combinations of expectations with observations. As a result, phenotypic remission ought to take some time as the brain's relevant statistical structures become less pessimistic. PMID:25750630

  10. [The effects of concomitant pictorial information on the memory and comprehension of story].

    PubMed

    Kitao, N; Okamoto, M

    1993-02-01

    The present study was carried out to examine the effect of movement and coloring of concomitant pictures on children's story learning. The story was Hans Christian Andersen's HINAGIKU (daisy), which was 47 sentences long. In relation to the story, the subjects in experimental groups were presented the static or moving pictures by means of picture-card show or animation video. Those pictures were colored or uncolored. Immediately after the story learning, the subjects were given verbative recall and inferential tests. The 156 second graders were assigned to one of four experimental groups and a control group (without pictures). The main findings were as follows; (1) The coloring of picture had facilitative effects on the verbative recall of story. This result indicates that clear visual imagery improved the memory of story. (2) The moving of picture facilitated the inferential test performance. This result indicates that the movement of picture clarified the story context and gave a lot of cue information to comprehend story.

  11. Higher order Riesz transforms associated with Bessel operators

    NASA Astrophysics Data System (ADS)

    Betancor, Jorge J.; Fariña, Juan C.; Martinez, Teresa; Rodríguez-Mesa, Lourdes

    2008-10-01

    In this paper we investigate Riesz transforms R μ ( k) of order k≥1 related to the Bessel operator Δμ f( x)=- f”( x)-((2μ+1)/ x) f’( x) and extend the results of Muckenhoupt and Stein for the conjugate Hankel transform (a Riesz transform of order one). We obtain that for every k≥1, R μ ( k) is a principal value operator of strong type ( p, p), p∈(1,∞), and weak type (1,1) with respect to the measure dλ( x)= x 2μ+1 dx in (0,∞). We also characterize the class of weights ω on (0,∞) for which R μ ( k) maps L p (ω) into itself and L 1(ω) into L 1,∞(ω) boundedly. This class of weights is wider than the Muckenhoupt class mathcal{A}p^μ of weights for the doubling measure dλ. These weighted results extend the ones obtained by Andersen and Kerman.

  12. Method for measuring the size distribution of airborne rhinovirus

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Russell, M.L.; Goth-Goldstein, R.; Apte, M.G.

    About 50% of viral-induced respiratory illnesses are caused by the human rhinovirus (HRV). Measurements of the concentrations and sizes of bioaerosols are critical for research on building characteristics, aerosol transport, and mitigation measures. We developed a quantitative reverse transcription-coupled polymerase chain reaction (RT-PCR) assay for HRV and verified that this assay detects HRV in nasal lavage samples. A quantitation standard was used to determine a detection limit of 5 fg of HRV RNA with a linear range over 1000-fold. To measure the size distribution of HRV aerosols, volunteers with a head cold spent two hours in a ventilated research chamber.more » Airborne particles from the chamber were collected using an Andersen Six-Stage Cascade Impactor. Each stage of the impactor was analyzed by quantitative RT-PCR for HRV. For the first two volunteers with confirmed HRV infection, but with mild symptoms, we were unable to detect HRV on any stage of the impactor.« less

  13. Going beyond The three worlds of welfare capitalism: regime theory and public health research.

    PubMed

    Bambra, C

    2007-12-01

    International research on the social determinants of health has increasingly started to integrate a welfare state regimes perspective. Although this is to be welcomed, to date there has been an over-reliance on Esping-Andersen's The three worlds of welfare capitalism typology (1990). This is despite the fact that it has been subjected to extensive criticism and that there are in fact a number of competing welfare state typologies within the comparative social policy literature. The purpose of this paper is to provide public health researchers with an up-to-date overview of the welfare state regime literature so that it can be reflected more accurately in future research. It outlines The three worlds of welfare capitalism typology, and it presents the criticisms it received and an overview of alternative welfare state typologies. It concludes by suggesting new avenues of study in public health that could be explored by drawing upon this broader welfare state regimes literature.

  14. Going beyond The three worlds of welfare capitalism: regime theory and public health research

    PubMed Central

    Bambra, C

    2007-01-01

    International research on the social determinants of health has increasingly started to integrate a welfare state regimes perspective. Although this is to be welcomed, to date there has been an over‐reliance on Esping‐Andersen's The three worlds of welfare capitalism typology (1990). This is despite the fact that it has been subjected to extensive criticism and that there are in fact a number of competing welfare state typologies within the comparative social policy literature. The purpose of this paper is to provide public health researchers with an up‐to‐date overview of the welfare state regime literature so that it can be reflected more accurately in future research. It outlines The three worlds of welfare capitalism typology, and it presents the criticisms it received and an overview of alternative welfare state typologies. It concludes by suggesting new avenues of study in public health that could be explored by drawing upon this broader welfare state regimes literature. PMID:18000134

  15. Radiation collimation in a thick crystalline undulator

    NASA Astrophysics Data System (ADS)

    Wistisen, Tobias Nyholm; Uggerhøj, Ulrik Ingerslev; Hansen, John Lundsgaard; Lauth, Werner; Klag, Pascal

    2017-05-01

    With the recent experimental confirmation of the existence of energetic radiation from a Small Amplitude, Small Period (SASP) crystalline undulator [T.N. Wistisen, K.K. Andersen, S. Yilmaz, R. Mikkelsen, J. Lundsgaard Hansen, U.I. Uggerhøj, W. Lauth, H. Backe, Phys. Rev. Lett. 112, 254801 (2014)], the field of specially manufactured crystals, from which specific radiation characteristics can be obtained, has evolved substantially. In this paper we confirm the existence of the crystalline undulator radiation, using electrons of energies of 855 GeV from the MAinzer MIcrotron (MAMI) in a crystal that is approximately 10 times thicker than the previous one. Furthermore, we have measured a significant increase in enhancement, in good agreement with calculations, of the undulator peak by collimation to angles smaller than the natural opening angle of the radiation emission process, 1 /γ. Contribution to the Topical Issue: "Dynamics of Systems at the Nanoscale", edited by Andrey Solov'yov and Andrei Korol.

  16. Ultra high resolution cation analysis of NGRIP deep ice via cryo-cell UV-laser-ablation ICPMS

    NASA Astrophysics Data System (ADS)

    Della Lunga, Damiano; Muller, Wolfgang; Olander Rasmussen, Sune; Svensson, Anders

    2014-05-01

    During glacial periods, Earth experienced abrupt climate change events that led to rapid natural warming/ cooling over a few years only (Steffensen et al., 2008). In order to investigate these rapid climate events especially in old thinned ice, highest spatial/time resolution analysis of climate proxies is required. A recently developed methodology at Royal Holloway University of London (Müller et al., 2011), which permits in situ chemical analysis of frozen ice with spatial (and thus time) resolution up to 0.1 mm (100 ?m) using cryo-cell UV-laser ablation inductively-coupled-plasma mass spectrometry (UV-LA-ICPMS), has been optimized and utilized for analysis of (major) elements indicative of dust and/or sea salt (e.g. Fe, Al, Ca, Mg, Na), while maintaining detection limits in the low(est) ppb-range. NGRIP samples of Greenland Stadial GS22 (~86 ka, depth of ~2690 m), representing a minor δ18O shift (of about ± 4) within the stadial phase of D-O event 22, have been selected and analysed. With a single storm-event resolution capability, seasonal, annual and multiannual periodicity of elements have been identified and will be presented with particular focus on the phasing of the climate proxies. Corresponding results include also an optimized UV-LA-ICPMS methodology, particularly with reference to depth-profiling, assessing contamination of the sample surface and standardization. Finally, the location and distribution of soluble and insoluble micro-inclusions in deep ice have also been assessed concerning the partitioning of elements between grain boundaries and grain interiors. Results show that impurities tend to be concentrated along boundaries in clear (winter) ice, whereas in cloudy bands ('dirtier' ice) they distribute equally between boundaries and interiors. References Müller, W., Shelley, J.M.G., Rasmussen, S.O., 2011. Direct chemical analysis of frozen ice cores by UV-laser ablation ICPMS. J. Anal. At. Spectrom. 26, 2391-2395. Steffensen, J.P., Andersen

  17. (18-Crown-6)potassium [(1,2,5,6-η)-cyclo­octa-1,5-diene][(1,2,3,4-η)-naph­tha­lene]­ferrate(−I)

    PubMed Central

    Brennessel, William W.; Ellis, John E.

    2012-01-01

    The title salt, [K(C12H24O6)][Fe(C8H12)(C10H8)], is the only known naphthalene complex containing iron in a formally negative oxidation state. Each (naphthalene)(1,5-cod)ferrate(−I) anion is in contact with one (18-crown-6)potassium cation via K⋯C contacts to the outer four carbon atoms of the naphthalene ligand (cod = 1,5-cyclo­octa­diene, 18-crown-6 = 1,4,7,10,13,16-hexa­oxacyclo­octa­deca­ne). When using the midpoints of the coordinating olefin bonds, the overall geometry of the coordination sphere around iron can be best described as distorted tetra­hedral. The naphthalene fold angle between the plane of the iron-coordinating butadiene unit and the plane containing the exo-benzene moiety is 19.2 (1)°. PMID:23125569

  18. Routes for the production of isotopes for PET with high intensity deuteron accelerators

    NASA Astrophysics Data System (ADS)

    Arias de Saavedra, F.; Porras, I.; Praena, J.

    2018-04-01

    Recent advances in accelerator science are opening new possibilities in different fields of physics. In particular, the development of compact linear accelerators that can provide charged particles of low-medium energy (few MeV) with high current (above mA) allows for the study of new possibilities in neutron production and for new routes for the production of radioisotopes. Keeping in mind how radioisotopes are actually produced in dedicated facilities, we have performed a study of alternative reactions to produce PET isotopes induced by low-energy deuterons. We have fitted the EXFOR cross sections data, used the fitted values of the stopping power by Andersen and Ziegler and calculated by numerical integration the production rate of isotopes for charged particles up to 20 MeV. The results for deuterons up to 3 MeV are compared with the ones from cyclotrons, which are able to provide higher energies to the charged projectiles but with lower intensities. Our results indicate that using linear accelerators may be a good alternative for producing PET isotopes, reducing the problem of neutron activation.

  19. Molecular dynamics simulations in hybrid particle-continuum schemes: Pitfalls and caveats

    NASA Astrophysics Data System (ADS)

    Stalter, S.; Yelash, L.; Emamy, N.; Statt, A.; Hanke, M.; Lukáčová-Medvid'ová, M.; Virnau, P.

    2018-03-01

    Heterogeneous multiscale methods (HMM) combine molecular accuracy of particle-based simulations with the computational efficiency of continuum descriptions to model flow in soft matter liquids. In these schemes, molecular simulations typically pose a computational bottleneck, which we investigate in detail in this study. We find that it is preferable to simulate many small systems as opposed to a few large systems, and that a choice of a simple isokinetic thermostat is typically sufficient while thermostats such as Lowe-Andersen allow for simulations at elevated viscosity. We discuss suitable choices for time steps and finite-size effects which arise in the limit of very small simulation boxes. We also argue that if colloidal systems are considered as opposed to atomistic systems, the gap between microscopic and macroscopic simulations regarding time and length scales is significantly smaller. We propose a novel reduced-order technique for the coupling to the macroscopic solver, which allows us to approximate a non-linear stress-strain relation efficiently and thus further reduce computational effort of microscopic simulations.

  20. Teichmüller TQFT vs. Chern-Simons theory

    NASA Astrophysics Data System (ADS)

    Mikhaylov, Victor

    2018-04-01

    Teichmüller TQFT is a unitary 3d topological theory whose Hilbert spaces are spanned by Liouville conformal blocks. It is related but not identical to PSL(2, ℝ) Chern-Simons theory. To physicists, it is known in particular in the context of 3d-3d correspondence and also in the holographic description of Virasoro conformal blocks. We propose that this theory can be defined by an analytically-continued Chern-Simons path-integral with an unusual integration cycle. On hyperbolic three-manifolds, this cycle is singled out by the requirement of invertible vielbein. Mathematically, our proposal translates a known conjecture by Andersen and Kashaev into a conjecture about the Kapustin-Witten equations. We further explain that Teichmüller TQFT is dual to complex SL(2, ℂ) Chern-Simons theory at integer level k = 1, clarifying some puzzles previously encountered in the 3d-3d correspondence literature. We also present a new simple derivation of complex Chern-Simons theories from the 6d (2,0) theory on a lens space with a transversely-holomorphic foliation.

  1. Bulk diffusion in a kinetically constrained lattice gas

    NASA Astrophysics Data System (ADS)

    Arita, Chikashi; Krapivsky, P. L.; Mallick, Kirone

    2018-03-01

    In the hydrodynamic regime, the evolution of a stochastic lattice gas with symmetric hopping rules is described by a diffusion equation with density-dependent diffusion coefficient encapsulating all microscopic details of the dynamics. This diffusion coefficient is, in principle, determined by a Green-Kubo formula. In practice, even when the equilibrium properties of a lattice gas are analytically known, the diffusion coefficient cannot be computed except when a lattice gas additionally satisfies the gradient condition. We develop a procedure to systematically obtain analytical approximations for the diffusion coefficient for non-gradient lattice gases with known equilibrium. The method relies on a variational formula found by Varadhan and Spohn which is a version of the Green-Kubo formula particularly suitable for diffusive lattice gases. Restricting the variational formula to finite-dimensional sub-spaces allows one to perform the minimization and gives upper bounds for the diffusion coefficient. We apply this approach to a kinetically constrained non-gradient lattice gas in two dimensions, viz. to the Kob-Andersen model on the square lattice.

  2. Extreme event statistics in a drifting Markov chain

    NASA Astrophysics Data System (ADS)

    Kindermann, Farina; Hohmann, Michael; Lausch, Tobias; Mayer, Daniel; Schmidt, Felix; Widera, Artur

    2017-07-01

    We analyze extreme event statistics of experimentally realized Markov chains with various drifts. Our Markov chains are individual trajectories of a single atom diffusing in a one-dimensional periodic potential. Based on more than 500 individual atomic traces we verify the applicability of the Sparre Andersen theorem to our system despite the presence of a drift. We present detailed analysis of four different rare-event statistics for our system: the distributions of extreme values, of record values, of extreme value occurrence in the chain, and of the number of records in the chain. We observe that, for our data, the shape of the extreme event distributions is dominated by the underlying exponential distance distribution extracted from the atomic traces. Furthermore, we find that even small drifts influence the statistics of extreme events and record values, which is supported by numerical simulations, and we identify cases in which the drift can be determined without information about the underlying random variable distributions. Our results facilitate the use of extreme event statistics as a signal for small drifts in correlated trajectories.

  3. Development of Biodegradable Polycation-Based Inhalable Dry Gene Powders by Spray Freeze Drying

    PubMed Central

    Okuda, Tomoyuki; Suzuki, Yumiko; Kobayashi, Yuko; Ishii, Takehiko; Uchida, Satoshi; Itaka, Keiji; Kataoka, Kazunori; Okamoto, Hirokazu

    2015-01-01

    In this study, two types of biodegradable polycation (PAsp(DET) homopolymer and PEG-PAsp(DET) copolymer) were applied as vectors for inhalable dry gene powders prepared by spray freeze drying (SFD). The prepared dry gene powders had spherical and porous structures with a 5~10-μm diameter, and the integrity of plasmid DNA could be maintained during powder production. Furthermore, it was clarified that PEG-PAsp(DET)-based dry gene powder could more sufficiently maintain both the physicochemical properties and in vitro gene transfection efficiencies of polyplexes reconstituted after powder production than PAsp(DET)-based dry gene powder. From an in vitro inhalation study using an Andersen cascade impactor, it was demonstrated that the addition of l-leucine could markedly improve the inhalation performance of dry powders prepared by SFD. Following pulmonary delivery to mice, both PAsp(DET)- and PEG-PAsp(DET)-based dry gene powders could achieve higher gene transfection efficiencies in the lungs compared with a chitosan-based dry gene powder previously reported by us. PMID:26343708

  4. Fungal spore concentrations in two haematopoietic stem cell transplantation (HSCT) units containing distinct air control systems.

    PubMed

    Brun, C P; Miron, D; Silla, L M R; Pasqualotto, A C

    2013-04-01

    Invasive fungal diseases have emerged as important causes of morbidity and mortality in haematological patients. In this study air samples were collected in two haematopoietic stem cell transplantation (HSCT) units, in which distinct air-control systems were in place. In hospital 1 no high-efficiency particulate air (HEPA) filter was available whereas in hospital 2 HSCT rooms were equipped with HEPA filters, with positive air pressure in relation to the corridor. A total of 117 samples from rooms, toilets and corridors were obtained during December 2009 to January 2011, using a six-stage Andersen sampler. In both hospitals, the concentration of potentially pathogenic fungi in the air was reduced in patients' rooms compared to corridors (P < 0·0001). Despite the presence of a HEPA filter in hospital 2, rooms in both hospitals showed similar concentrations of potentially pathogenic fungi (P = 0·714). These findings may be explained by the implementation of additional protective measures in hospital 1, emphasizing the importance of such measures in protected environments.

  5. Patterns of post-acute health care utilization after a severe traumatic brain injury: Results from the PariS-TBI cohort.

    PubMed

    Jourdan, Claire; Bayen, Eleonore; Darnoux, Emmanuelle; Ghout, Idir; Azerad, Sylvie; Ruet, Alexis; Vallat-Azouvi, Claire; Pradat-Diehl, Pascale; Aegerter, Philippe; Weiss, Jean-Jacques; Azouvi, Philippe

    2015-01-01

    To assess brain injury services utilization and their determinants using Andersen's model. Prospective follow-up of the PariS-TBI inception cohort. Out of 504 adults with severe traumatic brain injury (TBI), 245 survived and 147 received a 4-year outcome assessment (mean age 33 years, 80% men). Provision rates of medical, rehabilitation, social and re-entry services and their relations to patients' characteristics were assessed. Following acute care discharge, 78% of patients received physiotherapy, 61% speech/cognitive therapy, 50% occupational therapy, 41% psychological assistance, 63% specialized medical follow-up, 21% community re-entry assistance. Health-related need factors, in terms of TBI severity, were the main predictors of services. Provision of each therapy was significantly associated with corresponding speech, motor and psychological impairments. However, care provision did not depend on cognitive impairments and cognitive therapy was related to pre-disposing and geographical factors. Community re-entry assistance was provided to younger and more independent patients. These quantitative findings illustrate strengths and weaknesses of late brain injury care provision in urban France and highlight the need to improve treatment of cognitive impairments.

  6. A Developmental Perspective in Mental Health Services Use Among Adults with Mental Disorders.

    PubMed

    Huỳnh, Christophe; Caron, Jean; Pelletier, Marilou; Liu, Aihua; Fleury, Marie-Josée

    2018-07-01

    This study examined factors associated with mental health services (MHS) use by individuals with mental disorders within a developmental perspective of adulthood. Bivariate and multivariate analyses were conducted separately for each developmental stage on independent variables using the Andersen's behavioral health service model. For 18-29-year-old emerging adults (n = 141), autonomy, daily life/relations, Internet searching, alcohol dependence, cognitive impulsiveness, number of stressful events, and self-harm were associated with MHS use. For 30-49-year olds (n = 292), being female, country of origin, being on welfare, social integration, Internet searching, and number of stressful events were associated with MHS use. For 50-64-year-old middle-aged adults (n = 126), current occupation was associated with MHS use. Developing online resources for emerging adults may increase MHS use. For 30-49-year olds, outreach should target male, immigrants, and individuals less socially integrated and on welfare. For middle-aged adults, workplace programs that reduce stigma and offer psychological help could increase MHS use.

  7. The effects of consultation on over-the-counter medication purchasing decisions.

    PubMed

    Nichol, M B; McCombs, J S; Johnson, K A; Spacapan, S; Sclar, D A

    1992-11-01

    This article examines factors that predict changes in consumer purchasing decisions of nonprescription medications. Variables corresponding to factors in Andersen's behavioral model are measured, in addition to data regarding characteristics of the 17 pharmacy consultants who provided counseling services. One thousand seven hundred and thirteen consumers in five stores in southern California were provided consultation during a 6-month period, resulting in 25.4% of the patients purchasing a different drug than intended when entering the pharmacy, 1.3% being referred to a physician, and 13.4% not purchasing any over-the-counter medication at all. Logistic regression techniques demonstrated that one enabling variable (availability of generic medications), and four need factors (the discussion of clinical issues, short encounters, cough and cold products, and vitamin products) were significant predictors of the consumer's decision to purchase a different product than intended. Consultant characteristics (introversion, external locus of control) were also important predictors, but opposite the expected direction. Consumers who received information from female consultants were more likely to change their purchasing decisions.

  8. Factors affecting running performance in 6-12-year-olds: The Health Oriented Pedagogical Project (HOPP).

    PubMed

    Fredriksen, Per Morten; Mamen, Asgeir; Gammelsrud, Heidi; Lindberg, Morten; Hjelle, Ole Petter

    2018-05-01

    The purpose of this study was to examine factors affecting running performance in children. A cross-sectional study exploring the relationships between height, weight, waist circumference, muscle mass, body fat percentage, relevant biomarkers, and the Andersen intermittent running test in 2272 children aged 6 to 12 years. Parental education level was used as a non-physiological explanatory variable. Mean values (SD) and percentiles are presented as reference values. Height (β = 6.4, p < .0001), high values of haemoglobin (β = 18, p = .013) and low percentage of body fat (β = -7.5, p < .0001) showed an association with results from the running test. In addition, high parental education level showed a positive association with the running test. Boys display better running performance than girls at all age ages, except 7 years old, probably because of additional muscle mass and less fatty tissue. Height and increased level of haemoglobin positively affected running performance. Lower body fat percentage and high parental education level correlated with better running performance.

  9. Wetting behavior of nonpolar nanotubes in simple dipolar liquids for varying nanotube diameter and solute-solvent interactions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rana, Malay Kumar; Chandra, Amalendu, E-mail: amalen@iitk.ac.in

    2015-01-21

    Atomistic simulations of model nonpolar nanotubes in a Stockmayer liquid are carried out for varying nanotube diameter and nanotube-solvent interactions to investigate solvophobic interactions in generic dipolar solvents. We have considered model armchair type single-walled nonpolar nanotubes with increasing radii from (5,5) to (12,12). The interactions between solute and solvent molecules are modeled by the well-known Lennard-Jones and repulsive Weeks-Chandler-Andersen potentials. We have investigated the density profiles and microscopic arrangement of Stockmayer molecules, orientational profiles of their dipole vectors, time dependence of their occupation, and also the translational and rotational motion of solvent molecules in confined environments of the cylindricalmore » nanopores and also in their external peripheral regions. The present results of structural and dynamical properties of Stockmayer molecules inside and near atomistically rough nonpolar surfaces including their wetting and dewetting behavior for varying interactions provide a more generic picture of solvophobic effects experienced by simple dipolar liquids without any specific interactions such as hydrogen bonds.« less

  10. DNA Everywhere. A Guide for Simplified Environmental Genomic DNA Extraction Suitable for Use in Remote Areas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gabrielle N. Pecora; Francine C. Reid; Lauren M. Tom

    2016-05-01

    Collecting field samples from remote or geographically distant areas can be a financially and logistically challenging. With participation of a local organization where the samples are originated from, gDNA samples can be extracted from the field and shipped to a research institution for further processing and analysis. The ability to set up gDNA extraction capabilities in the field can drastically reduce cost and time when running long-term microbial studies with a large sample set. The method outlined here has developed a compact and affordable method for setting up a “laboratory” and extracting and shipping gDNA samples from anywhere in themore » world. This white paper explains the process of setting up the “laboratory”, choosing and training individuals with no prior scientific experience how to perform gDNA extractions and safe methods for shipping extracts to any research institution. All methods have been validated by the Andersen group at Lawrence Berkeley National Laboratory using the Berkeley Lab PhyloChip.« less

  11. Local structure order in Pd 78Cu 6Si 16 liquid

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yue, G. Q.; Zhang, Y.; Sun, Y.

    2015-02-05

    The short-range order (SRO) in Pd 78Cu 6Si 16 liquid was studied by high energy x-ray diffraction and ab initio molecular dynamics (MD) simulations. The calculated pair correlation functions at different temperatures agree well with the experimental results. The partial pair correlation functions from ab intio MD simulations indicate that Si atoms prefer to be uniformly distributed while Cu atoms tend to aggregate. By performing structure analysis using Honeycutt-Andersen index, Voronoi tessellation, and atomic cluster alignment method, we show that the icosahedron and face-centered cubic SRO increase upon cooling. The dominant SRO is the Pd-centered Pd 9Si 2 motif, namelymore » the structure of which motif is similar to the structure of Pd-centered clusters in the Pd 9Si 2 crystal. The study further confirms the existence of trigonal prism capped with three half-octahedra that is reported as a structural unit in Pd-based amorphous alloys. The majority of Cu-centered clusters are icosahedra, suggesting that the presence of Cu is benefit to promote the glass forming ability.« less

  12. Bicanonical ab Initio Molecular Dynamics for Open Systems.

    PubMed

    Frenzel, Johannes; Meyer, Bernd; Marx, Dominik

    2017-08-08

    Performing ab initio molecular dynamics simulations of open systems, where the chemical potential rather than the number of both nuclei and electrons is fixed, still is a challenge. Here, drawing on bicanonical sampling ideas introduced two decades ago by Swope and Andersen [ J. Chem. Phys. 1995 , 102 , 2851 - 2863 ] to calculate chemical potentials of liquids and solids, an ab initio simulation technique is devised, which introduces a fictitious dynamics of two superimposed but otherwise independent periodic systems including full electronic structure, such that either the chemical potential or the average fractional particle number of a specific chemical species can be kept constant. As proof of concept, we demonstrate that solvation free energies can be computed from these bicanonical ab initio simulations upon directly superimposing pure bulk water and the respective aqueous solution being the two limiting systems. The method is useful in many circumstances, for instance for studying heterogeneous catalytic processes taking place on surfaces where the chemical potential of reactants rather than their number is controlled and opens a pathway toward ab initio simulations at constant electrochemical potential.

  13. Optimisation of powders for pulmonary delivery using supercritical fluid technology.

    PubMed

    Rehman, Mahboob; Shekunov, Boris Y; York, Peter; Lechuga-Ballesteros, David; Miller, Danforth P; Tan, Trixie; Colthorpe, Paul

    2004-05-01

    Supercritical fluid technology exploited in this work afforded single-step production of respirable particles of terbutaline sulphate (TBS). Different crystal forms of TBS were produced consistently, including two polymorphs, a stoichiometric monohydrate and amorphous material as well as particles with different degrees of crystallinity, size, and morphology. Different solid-state and surface characterisation techniques were applied in conjunction with measurements of powder flow properties using AeroFlow device and aerosol performance by Andersen Cascade Impactor tests. Improved fine particle fraction (FPF) was demonstrated for some powders produced by the SCF process when compared to the micronised material. Such enhanced flow properties and dispersion correlated well with the reduced surface energy parameters demonstrated by these powders. It is shown that semi-crystalline particles exhibited lower specific surface energy leading to a better performance in the powder flow and aerosol tests than crystalline materials. This difference of the surface and bulk crystal structure for selected powder batches is explained by the mechanism of precipitation in SCF which can lead to surface conditioning of particles produced.

  14. AIRBORNE MICROORGANISMS IN BROILER PROCESSING PLANTS.

    PubMed

    KOTULA, A W; KINNER, J A

    1964-05-01

    Concentrations of total aerobic bacteria, molds, yeasts, coliforms, enterococci, and psychrophiles were determined in the air of two poultry processing plants with Andersen samplers and a mobile power supply. Total aerobic bacterial counts were highest in the dressing room, with diminishing numbers in the shackling, eviscerating, and holding rooms, when sampling was carried out during plant operation. The average counts per ft(3) of air in these four rooms were 2,200; 560; 230; and 62, respectively. (Each value is the average of 36 observations.) The number of organisms increased in the shackling and dressing rooms once processing was begun. Average total aerobic bacterial counts increased from 70 to 870 to 3,000 in the shackling room and from 310 to 4,900 to 7,000 in the dressing room when sampling was carried out at 5:00 am (before plant operations), 9:00 am, and 2:00 pm, respectively. (Each value is the mean of 12 observations.) Airborne molds might originate from a source other than the poultry being processed.

  15. Airborne Microorganisms in Broiler Processing Plants

    PubMed Central

    Kotula, Anthony W.; Kinner, Jack A.

    1964-01-01

    Concentrations of total aerobic bacteria, molds, yeasts, coliforms, enterococci, and psychrophiles were determined in the air of two poultry processing plants with Andersen samplers and a mobile power supply. Total aerobic bacterial counts were highest in the dressing room, with diminishing numbers in the shackling, eviscerating, and holding rooms, when sampling was carried out during plant operation. The average counts per ft3 of air in these four rooms were 2,200; 560; 230; and 62, respectively. (Each value is the average of 36 observations.) The number of organisms increased in the shackling and dressing rooms once processing was begun. Average total aerobic bacterial counts increased from 70 to 870 to 3,000 in the shackling room and from 310 to 4,900 to 7,000 in the dressing room when sampling was carried out at 5:00 am (before plant operations), 9:00 am, and 2:00 pm, respectively. (Each value is the mean of 12 observations.) Airborne molds might originate from a source other than the poultry being processed. Images FIG. 3 PMID:14170951

  16. A Symposium Associated with the Opening of the Play Copenhagen in Washington

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schwartz, Brian

    On March 2, 2002 a special all day symposium was held in conjunction with the opening of the play Copenhagen in Washington. The play Copenhagen reenacts the 1941 visit of Werner Heisenberg, who was then in charge of the Nazi nuclear power program, to Niels Bohr, his mentor, and collaborator in creating quantum mechanics, complementarity, and the uncertainty principle, in German-occupied Denmark. The symposium entitled: THE COPENHAGEN INTERPRETATION: SCIENCE AND HISTORY ON STAGE was presented at the Baird Auditorium, in the National Museum of Natural History of the Smithsonian Institution. The program consisted of three two-hour sessions: (1) The Sciencemore » of Copenhagen and its Influence of the 20th Century. (2) Bohr and Heisenberg: A strong Interaction. (3) Theater as Science ??? Science as Theater. The speakers included: Robert C. Card, Under Secretary of Energy; Ulrik Federspiel, Danish Ambassador to the US; John Marburger, III, Science Advisor President Bush; Jerome I. Friedman, MIT; Lene Vestergaard Hau, Harvard University; Richard Rhodes, Author; Rita Colwell, Director, NSF; Jeremy Bernstein, Author; Jochen H. Heisenberg, University of New Hampshire; Finn Aaserud, Director of the Niels Bohr Archive; Vilhelm A. Bohr, NIH; Thomas Powers, Author; Paul Lawrence Rose, Penn State University; Steven Barfield, University of Westminster, Jennifer Uphoff Gray, Associate Director, Copenhagen; Elizabeth Ireland McCann, Producer, Copenhagen; Lloyd Rose, Washington Post. Details of he program and useful information on the play Copenhagen are available on the web site http://web.gc.cuny.edu/ashp/nml/artsci/copenhagen.shtml . The complete symposium was video recorded and the set of 3 two-hour tapes can be obtained through the web site. The symposium was organized by Brian Schwartz, The Graduate Center, CUNY, Harry Lustig, Provost Emeritus at the City College of New York and Arthur Molella, Director, Lemelson Center, Smithsonian Institution. For further information

  17. Effect of Collagen Matrix Saturation on the Surface Free Energy of Dentin using Different Agents.

    PubMed

    de Almeida, Leopoldina de Fátima Dantas; Souza, Samilly Evangelista; Sampaio, Aline Araújo; Cavalcanti, Yuri Wanderley; da Silva, Wander José; Del Bel Cur, Altair A; Hebling, Josimeri

    2015-07-01

    The surface free energy of conditioned-dentin is one of the factors that interfere with monomeric infiltration of the interfibrillar spaces. Saturation of the tooth matrix with different substances may modulate this energy and, consequently, the wettability of the dentin. To evaluate the influence of different substances used to saturate conditioned-dentin on surface free energy (SFE) of this substrate. Dentin blocks (4 × 7 × 1 mm, n = 6/ group), obtained from the roots of bovine incisors, were etched using phosphoric acid for 15 seconds, rinsed and gently dried. The surfaces were treated for 60 seconds with: ultra-purified water (H20-control); ethanol (EtOH), acetone (ACT), chlorhexidine (CHX), ethylenediaminetetraacetic acid (EDTA); or sodium hypochlorite (NaOCl). The tooth surfaces were once again dried with absorbent paper and prepared for SFE evaluation using three standards: water, formamide and bromonaphthalene. Analysis of variance (ANOVA) and Dunnet's tests (a = 0.05) were applied to the data. Ethylenediaminetetraacetic acid was the only substance that caused a change to the contact angle for the standards water and formamide, while only EtOH influenced the angles formed between formamide and the dentin surface. None of the substances exerted a significant effect for bromonaphtha-lene. In comparison to the control, only EDTA and NaOCl altered both polar components of the SFE. Total SFE was increased by saturation of the collagen matrix by EDTA and reduced when NaOCl was used. Saturation of the collagen matrix by EDTA and EtOH changed the surface free energy of the dentin. In addition, the use of NaOCl negatively interfered with the properties evaluated. The increase of surface free energy and wettability of the dentin surface would allow higher penetration of the the adhesive system, which would be of importance to the clinical success of resin-dentin union.

  18. Crystal structures of ten enanti­opure Schiff bases bearing a naphthyl group

    PubMed Central

    Hernández-Téllez, Guadalupe; Moreno, Gloria E.; Bernès, Sylvain; Mendoza, Angel; Portillo, Oscar; Sharma, Pankaj; Gutiérrez, René

    2016-01-01

    Using a general solvent-free procedure for the synthesis of chiral Schiff bases, the following compounds were synthesized and their crystal structures determined: (S)-(+)-2-{[(1-phenyl­eth­yl)imino]­meth­yl}naphthalene, C19H17N, (1), (S)-(+)-2-({[(4-methyl­phen­yl)eth­yl]imino}­meth­yl)naphthalene, C20H19N, (2), (R)-(−)-2-({[(4-meth­oxy­lphen­yl)eth­yl]imino}­meth­yl)naphthalene, C20H19NO, (3), (R)-(−)-2-({[(4-fluoro­phen­yl)eth­yl]imino}­meth­yl)naphthalene, C19H16FN, (4), (S)-(+)-2-({[(4-chloro­phen­yl)eth­yl]imino}­meth­yl)naphthalene, C19H16ClN, (5), (S)-(+)-2-({[(4-bromo­phen­yl)eth­yl]imino}­meth­yl)naphthalene, C19H16BrN, (6), (S)-(+)-2-({[1-(naphthalen-1-yl)eth­yl]imino}­meth­yl)naph­thalene, C23H19N, (7), (S)-(+)-2-{[(1-cyclo­hexyl­eth­yl)imino]­meth­yl}naph­tha­lene, C19H23N, (8), (S)-(−)-2-{[(1,2,3,4-tetra­hydro­naphthalen-1-yl)imino]meth­yl}naphthalene, C21H19N, (9), and (+)-2-({[(1S,2S,3S,5R)-2,6,6-tri­methylbi­cyclo­[3.1.1]hept-3-yl]imino}­meth­yl}naphthalene, C21H25N, (10). The moiety provided by the amine generates conformational flexibility for these imines. In the crystals, no strong inter­molecular contacts are observed, in spite of the presence of aromatic groups. PMID:27375893

  19. Development and performance of a 129-GHz dynamic nuclear polarizer in an ultra-wide bore superconducting magnet

    PubMed Central

    Lumata, Lloyd L.; Martin, Richard; Jindal, Ashish K.; Kovacs, Zoltan; Conradi, Mark S.

    2014-01-01

    Objective We sought to build a dynamic nuclear polarization system for operation at 4.6 T (129 GHz) and evaluate its efficiency in terms of 13C polarization levels using free radicals that span a range of ESR linewidths. Materials and methods A liquid helium cryostat was placed in a 4.6 T superconducting magnet with a 150-mm warm bore diameter. A 129-GHz microwave source was used to irradiate 13C enriched samples. Temperatures close to 1 K were achieved using a vacuum pump with a 453-m3/h roots blower. A hyperpolarized 13C nuclear magnetic resonance (NMR) signal was detected using a saddle coil and a Varian VNMRS console operating at 49.208 MHz. Samples doped with free radicals BDPA (1,3-bisdipheny-lene-2-phenylallyl), trityl OX063 (tris{8-carboxyl-2,2,6,6-benzo(1,2-d:4,5-d)-bis(1,3)dithiole-4-yl}methyl sodium salt), galvinoxyl ((2,6-di-tert-butyl-α-(3,5-di-tert-butyl-4-oxo-2,5-cyclohexadien-1-ylidene)-p-tolyloxy), 2,2-diphenylpicrylhydrazyl (DPPH) and 4-oxo-TEMPO (4-Oxo-2,2,6,6-tetramethyl-1-piperidinyloxy) were assayed. Microwave dynamic nuclear polarization (DNP) spectra and solid-state 13C polarization levels for these samples were determined. Results 13C polarization levels close to 50 % were achieved for [1-13C]pyruvic acid at 1.15 K using the narrow electron spin resonance (ESR) linewidth free radicals trityl OX063 and BDPA, while 10–20 % 13C polarizations were achieved using galvinoxyl, DPPH and 4-oxo-TEMPO. Conclusion At this field strength free radicals with smaller ESR linewidths are still superior for DNP of 13C as opposed to those with linewidths that exceed that of the 1H Larmor frequency. PMID:25120071

  20. GOCE User Toolbox and Tutorial

    NASA Astrophysics Data System (ADS)

    Knudsen, P.; Benveniste, J.

    2011-07-01

    The GOCE User Toolbox GUT is a compilation of tools for the utilisation and analysis of GOCE Level 2 products. GUT support applications in Geodesy, Oceanography and Solid Earth Physics. The GUT Tutorial provides information and guidance in how to use the toolbox for a variety of applications. GUT consists of a series of advanced computer routines that carry out the required computations. It may be used on Windows PCs, UNIX/Linux Workstations, and Mac. The toolbox is supported by The GUT Algorithm Description and User Guide and The GUT Install Guide. A set of a-priori data and models are made available as well. GUT has been developed in a collaboration within the GUT Core Group. The GUT Core Group: S. Dinardo, D. Serpe, B.M. Lucas, R. Floberghagen, A. Horvath (ESA), O. Andersen, M. Herceg (DTU), M.-H. Rio, S. Mulet, G. Larnicol (CLS), J. Johannessen, L.Bertino (NERSC), H. Snaith, P. Challenor (NOC), K. Haines, D. Bretherton (NCEO), C. Hughes (POL), R.J. Bingham (NU), G. Balmino, S. Niemeijer, I. Price, L. Cornejo (S&T), M. Diament, I Panet (IPGP), C.C. Tscherning (KU), D. Stammer, F. Siegismund (UH), T. Gruber (TUM),

  1. On the carriers of the 21μm emission feature in post-asymptotic giant branch stars

    NASA Astrophysics Data System (ADS)

    Zhang, Ke; Jiang, B. W.; Li, Aigen

    2009-07-01

    The mysterious 21μm emission feature seen in sixteen C-rich proto-planetary nebulae (PPNe) remains unidentified since its discovery in 1989. Over a dozen of materials are suggested as the carrier candidates. In this work, we quantitatively investigate eight inorganic and one organic carrier candidates in terms of elemental abundance constraints, while previous studies mostly focus on their spectral profiles (which could be largely affected by grain size, shape and clustering effects). It is found that: (1) five candidates (TiC nanoclusters, fullerenes coordinated with Ti atoms, SiS2, doped-SiC and SiO2-coated SiC dust) violate the abundance constraints (i.e. they require too much Ti, S or Si to account for the emission power of the 21μm band, (2) three candidates (carbon and silicon mixtures, Fe2O3 and Fe3O4), while satisfying the abundance constraints, exhibit secondary features which are not detected in the 21μm sources and (3) nano FeO, neither exceeding the abundance budget nor producing undetected secondary features, seems to be a viable candidate, supporting the suggestions of Posch, Mutschke & Andersen.

  2. Dynamic heterogeneity in crossover spin facilitated model of supercooled liquid and fractional Stokes-Einstein relation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Choi, Seo-Woo; Kim, Soree; Jung, YounJoon, E-mail: yjjung@snu.ac.kr

    Kinetically constrained models have gained much interest as models that assign the origins of interesting dynamic properties of supercooled liquids to dynamical facilitation mechanisms that have been revealed in many experiments and numerical simulations. In this work, we investigate the dynamic heterogeneity in the fragile-to-strong liquid via Monte Carlo method using the model that linearly interpolates between the strong liquid-like behavior and the fragile liquid-like behavior by an asymmetry parameter b. When the asymmetry parameter is sufficiently small, smooth fragile-to-strong transition is observed both in the relaxation time and the diffusion constant. Using these physical quantities, we investigate fractional Stokes-Einsteinmore » relations observed in this model. When b is fixed, the system shows constant power law exponent under the temperature change, and the exponent has the value between that of the Frederickson-Andersen model and the East model. Furthermore, we investigate the dynamic length scale of our systems and also find the crossover relation between the relaxation time. We ascribe the competition between energetically favored symmetric relaxation mechanism and entropically favored asymmetric relaxation mechanism to the fragile-to-strong crossover behavior.« less

  3. The characterisation of atomic structure and glass-forming ability of the Zr-Cu-Co metallic glasses studied by molecular dynamics simulations

    NASA Astrophysics Data System (ADS)

    Celtek, M.; Sengul, S.

    2018-03-01

    In the present work, the glass formation process and structural properties of Zr50Cu50-xCox (0 ≤ x ≤ 50) bulk metallic glasses were investigated by a molecular dynamics simulation with the many body tight-binding potentials. The evolution of structure and glass formation process with temperature were discussed using the coordination number, the radial distribution functions, the volume-temperature curve, icosahedral short-range order, glass transition temperature, Voronoi analysis, Honeycutt-Andersen pair analysis technique and the distribution of bond-angles. Results indicate that adding Co causes similar responses on the nature of the Zr50Cu50-xCox (0 ≤ x ≤ 50) alloys except for higher glass transition temperature and ideal icosahedral type ordered local atomic environment. Also, the differences of the atomic radii play the key role in influencing the atomic structure of these alloys. Both Cu and Co atoms play a significant role in deciding the chemical and topological short-range orders of the Zr50Cu50-xCox ternary liquids and amorphous alloys. The glass-forming ability of these alloys is supported by the experimental observations reported in the literature up to now.

  4. Effects of comorbid health conditions on healthcare expenditures among people with severe mental illness.

    PubMed

    Lee, Sungkyu; Rothbard, Aileen; Choi, Sunha

    2016-08-01

    Little is known about the incremental cost burden associated with treating comorbid health conditions among people with severe mental illness (SMI). This study compares the extent to which each individual medical condition increases healthcare expenditures between people with SMI and people without mental illness. Data were obtained from the 2011 Medical Expenditure Panel Survey (MEPS; N = 17 764). Mental illness and physical health conditions were identified through ICD-9 codes. Guided by the Andersen's behavioral model of health services utilization, generalized linear models were conducted. Total healthcare expenditures among individuals with SMI were approximately 3.3 times greater than expenditures by individuals without mental illness ($11 399 vs. $3449, respectively). Each additional physical health condition increased the total healthcare expenditure by 17.4% for individuals with SMI compared to the 44.8% increase for individuals without mental illness. The cost effect of having additional health conditions on the total healthcare expenditures among individuals with SMI is smaller than those individuals without mental illness. Whether this is due to limited access to healthcare for the medical problems or better coordination between medical and mental health providers, which reduces duplicated medical procedures or visits, requires future investigation.

  5. Health-Related Quality of Life and Its Correlates among Chinese Migrants in Small- and Medium-Sized Enterprises in Two Cities of Guangdong

    PubMed Central

    Lu, Liming; Zou, Guanyang; Zeng, Zhi; Han, Lu; Guo, Yan; Ling, Li

    2014-01-01

    Objectives To explore the relationship between health-related quality of life (HRQOL) status and associated factors among rural-to-urban migrants in China. Methods A cross-sectional survey was conducted with 856 rural-to-urban migrants working at small- and medium-size enterprises (SMEs) in Shenzhen and Zhongshan City in 2012. Andersen's behavioral model was used as a theoretical framework to exam the relationships among factors affecting HRQOL. Analysis was performed using structural equation modeling (SEM). Results Workers with statutory working hours, higher wages and less migrant experience had higher HRQOL scores. Need (contracting a disease in the past two weeks and perception of needing health service) had the greatest total effect on HRQOL (β = −0.78), followed by enabling (labor contract, insurance purchase, income, physical examination during work and training) (β = 0.40), predisposing (age, family separation, education) (β = 0.22) and health practices and use of health service (physical exercise weekly, health check-up and use of protective equipments) (β = −0.20). Conclusions Priority should be given to satisfy the needs of migrant workers, and improve the enabling resources. PMID:24392084

  6. The Toxicology of Carbon Nanotubes

    NASA Astrophysics Data System (ADS)

    Donaldson, Ken; Poland, Craig; Duffin, Rodger; Bonner, James

    2012-06-01

    1. Carbon nanotube structure, synthesis and applications C. Singh and W. Song; 2. The aerodynamic behaviour and pulmonary deposition of carbon nanotubes A. Buckley, R. Smith and R Maynard; 3. Utilising the concept of the biologically effective dose to define the particle and fibre hazards of carbon nanotubes K. Donaldson, R. Duffin, F. Murphy and C. Poland; 4. CNT, biopersistence and the fibre paradigm D. Warheit and M. DeLorme; 5. Length-dependent retention of fibres in the pleural space C. Poland, F. Murphy and K. Donaldson; 6. Experimental carcinogenicity of carbon nanotubes in the context of other fibres K. Unfried; 7. Fate and effects of carbon nanotubes following inhalation J. Ryman-Rasmussen, M. Andersen and J. Bonner; 8. Responses to pulmonary exposure to carbon nanotubes V. Castranova and R. Mercer; 9. Genotoxicity of carbon nanotubes R. Schins, C. Albrecht, K. Gerloff and D. van Berlo; 10. Carbon nanotube-cellular interactions; macrophages, epithelial and mesothelial cells V. Stone, M. Boyles, A. Kermanizadeh, J. Varet and H. Johnston; 11. Systemic health effects of carbon nanotubes following inhalation J. McDonald; 12. Dosimetry and metrology of carbon nanotubes L. Tran, L. MacCalman and R. Aitken; Index.

  7. Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance.

    PubMed

    Bosquillon, C; Lombry, C; Préat, V; Vanbever, R

    2001-02-23

    The objective of this study was to determine the effects of formulation excipients and physical characteristics of inhalation particles on their in vitro aerosolization performance, and thereby to maximize their respirable fraction. Dry powders were produced by spray-drying using excipients that are FDA-approved for inhalation as lactose, materials that are endogenous to the lungs as albumin and dipalmitoylphosphatidylcholine (DPPC); and/or protein stabilizers as trehalose or mannitol. Dry powders suitable for deep lung deposition, i.e. with an aerodynamic diameter of individual particles <3 microm, were prepared. They presented 0.04--0.25 g/cm(3) bulk tap densities, 3--5 microm geometric particle sizes, up to 90% emitted doses and 50% respirable fractions in the Andersen cascade impactor using a Spinhaler inhaler device. The incorporation of lactose, albumin and DPPC in the formulation all improved the aerosolization properties, in contrast to trehalose and the mannitol which decreased powder flowability. The relative proportion of the excipients affected aerosol performance as well. The lower the bulk powder tap density, the higher the respirable fraction. Optimization of in vitro aerosolization properties of inhalation dry powders can be achieved by appropriately selecting composition and physical characteristics of the particles.

  8. Capability of air filters to retain airborne bacteria and molds in heating, ventilating and air-conditioning (HVAC) systems.

    PubMed

    Möritz, M; Peters, H; Nipko, B; Rüden, H

    2001-07-01

    The capability of air filters (filterclass: F6, F7) to retain airborne outdoor microorganisms was examined in field experiments in two heating, ventilating and air conditioning (HVAC) systems. At the beginning of the 15-month investigation period, the first filter stages of both HVAC systems were equipped with new unused air filters. The number of airborne bacteria and molds before and behind the filters were determined simultaneously in 14 days-intervals using 6-stage Andersen cascade impactors. Under relatively dry (< 80% R. H.) and warm (> 12 degrees C) outdoor air conditions air filters led to a marked reduction of airborne microorganism concentrations (bacteria by approximately 70% and molds by > 80%). However, during long periods of high relative humidity (> 80% R. H.) a proliferation of bacteria on air filters with subsequent release into the filtered air occurred. These microorganisms were mainly smaller than 1.1 microns therefore being part of the respirable fraction. The results showed furthermore that one possibility to avoid microbial proliferation is to limit the relative humidity in the area of the air filters to 80% R. H. (mean of 3 days), e.g. by using preheaters in front of air filters in HVAC-systems.

  9. Dissatisfaction with the dental services and associated factors among adults.

    PubMed

    Roberto, Luana Leal; Martins, Andréa Maria Eleutério de Barros Lima; Paula, Alfredo Maurício Batista de; Ferreira, Efigênia Ferreira E; Haikal, Desirée Sant' Ana

    2017-05-01

    This study aimed to identify factors associated with dissatisfaction with dental services among adults. It analyzed 830 adult participants of an epidemiological survey of oral health. The dependent variable was dissatisfaction with the dental service, and the independent ones were selected according to the theoretical model set forth by Andersen and Davidson (1997). Estimates were corrected by the sample design effect, and Binary Logistic Regression was carried out. It was found that about 11% of adults were dissatisfied with the dental service. In the final model, dissatisfaction with dental services was lower among older adults (OR = 0.559) and among smokers (OR = 0.332). On the other hand, it was higher among adults who self-perceived their chewing as negative (OR = 2,804), who self-perceived some discomfort in the mouth and head and neck region (OR = 2.065), and among those who did not have access to information on how to avoid oral problems (OR = 3.020). Therefore, the services need to access the perceptions and expectations expressed by users, and provide information in appropriate quantity and quality, in the context of "health literacy" in order to achieve greater satisfaction among its users.

  10. Sources of Biased Inference in Alcohol and Drug Services Research: An Instrumental Variable Approach

    PubMed Central

    Schmidt, Laura A.; Tam, Tammy W.; Larson, Mary Jo

    2012-01-01

    Objective: This study examined the potential for biased inference due to endogeneity when using standard approaches for modeling the utilization of alcohol and drug treatment. Method: Results from standard regression analysis were compared with those that controlled for endogeneity using instrumental variables estimation. Comparable models predicted the likelihood of receiving alcohol treatment based on the widely used Aday and Andersen medical care–seeking model. Data were from the National Epidemiologic Survey on Alcohol and Related Conditions and included a representative sample of adults in households and group quarters throughout the contiguous United States. Results: Findings suggested that standard approaches for modeling treatment utilization are prone to bias because of uncontrolled reverse causation and omitted variables. Compared with instrumental variables estimation, standard regression analyses produced downwardly biased estimates of the impact of alcohol problem severity on the likelihood of receiving care. Conclusions: Standard approaches for modeling service utilization are prone to underestimating the true effects of problem severity on service use. Biased inference could lead to inaccurate policy recommendations, for example, by suggesting that people with milder forms of substance use disorder are more likely to receive care than is actually the case. PMID:22152672

  11. Concomitant presentation of Anderson-Tawil syndrome and myasthenia gravis in an adult patient: A case report.

    PubMed

    Fan, Rui; Ji, Ruirui; Zou, Wenxin; Wang, Guoliang; Wang, Hu; Penney, Daniel James; Luo, Jin Jun; Fan, Yuxin

    2016-10-01

    Andersen-Tawil syndrome (ATS) is an autosomal dominant, multisystem channelopathy characterized by periodic paralysis, ventricular arrhythmias and distinctive dysmorphic facial or skeletal features. The disorder displays marked intrafamilial variability and incomplete penetrance. Myasthenia gravis (MG) is an autoimmune disorder that demonstrates progressive fatigability, in which the nicotinic acetylcholine receptor (AChR) at neuromuscular junctions is the primary autoantigen. The present study reports a rare case of a 31-year-old woman with a history of morbid obesity and periodic weakness, who presented with hemodynamic instability, cardiogenic shock and facial anomalies. Laboratory results revealed hypokalemia and an elevated anti-AChR antibody expression levels. Electrocardiography demonstrated prolonged QT-interval, ST-elevation, and subsequent third-degree atrioventricular block. Neurological examination revealed bilateral ptosis, horizontal diplopia, dysarthria and generalized weakness. No mutations in the potassium channel inwardly rectifying subfamily J member 2 gene were detected in the present case. The patient was treated with oral potassium supplementation and an acetylcholinesterase inhibitor (pyridostigmine), after which the symptoms were improved. To the best of our knowledge, the present case report was the first to describe concomitant presentation of both ATS and MG, which represents a diagnostic and therapeutic challenge.

  12. Determinants of Usual Source of Care Disparities among African American and Caribbean Black Men: Findings from the national Survey of american life

    PubMed Central

    Hammond, Wizdom Powell; Mohottige, Dinushika; Chantala, Kim; Hastings, Julia F.; Neighbors, Harold W.; Snowden, Lonnie

    2011-01-01

    Purpose The Aday-Andersen model was used as a framework for investigating the contribution of immigration status (i.e., nativity and acculturation), socioeconomic factors, health care access, health status, and health insurance to usual source of health care (USOC) in a nationally representative sample of African American (n5551) and Caribbean Black men (n51,217). Methods We used the 2001–2003 National Survey of American Life, a nationally representative household survey of non-institutionalized U.S. Blacks to conduct descriptive and logistic regression analyses. Results Older age, more health conditions, neighborhood medical clinic access, and health insurance were associated with higher odds of reporting a USOC. Odds were lower for men with lower-middle incomes and poorer mental health status. Having health insurance was associated with higher odds of reporting a USOC for African American men but lower odds among Caribbean Black men. Odds were higher in the presence of more health conditions for African American men than for Caribbean Black men. Conclusions Health care reform policies aimed solely at increasing health insurance may not uniformly eliminate USOC disparities disfavoring U.S. and foreign-born non-Hispanic Black men. PMID:21317513

  13. Occupational exposure to airborne fungi among rice mill workers with special reference to aflatoxin producing A. flavus strains.

    PubMed

    Desai, Manisha Rajib; Ghosh, Sandip

    2003-01-01

    A study was undertaken on environmental mycoflora of rice mills situated in Bawla town, Ahmedabad district. The airborne fungal communities were isolated and identified quantitatively by using Andersen-6-stage viable sampler, midget impinger and high volume samplers (Cone and Hexhlet for total and respirable dusts respectively). Of all the isolates, genus Aspergillus was predominant and among the Aspergillus species, A. flavus was the common isolate, irrespective of the method applied for sample collection. Number of isolates recovered from the working place was significantly greater (p < 0.01) compared to control. Total percentage of aflatoxin positive strains of A. flavus was 8 %. These aflatoxin producing strains were identified on various media, such as Czapek agar (Cz) with 0.05 % anisaldehyde, APA and CAM. Surface morphology of aflatoxin positive strains was studied by SEM. Highly significant total and respirable dust concentrations were found in the work place (p < 0.01) whereas in the store, only the total dust concentration was significantly higher (p < 0.05) than the control site. The study indicates that the rice mill workers are occupationally exposed to airborne aflatoxin producing strains of A. flavus. Thus, they require protective mask for their safety.

  14. Cancer literacy as a mediator for cancer screening behaviour in Korean adults.

    PubMed

    Lee, Hee Yun; Rhee, Taeho Greg; Kim, Nam Keol

    2016-09-01

    This study investigates the cancer literacy level in Korean adults and examines whether cancer literacy plays a mediating role in the relationship between population characteristics and cancer screening behaviours. We collected data from 585 community-dwelling adults in Korea using self-administered surveys and face-to-face interviews from October to December in 2009. Guided by Andersen's behavioural model, we used a structural equation model to estimate the effect of cancer literacy as a mediator and found that cancer literacy mediated cancer screening behaviour. In the individual path analysis models, cancer literacy played a significant mediating role for the use of eastern medicine, fatalism, health status and the number of chronic diseases. When controlling for other relevant covariates, we found that in the optimal path model, cancer literacy played a mediating role in the relationship between the use of eastern medicine and self-rated health status as well as cancer screening behaviour. Thus, developing community-based cancer education programmes and training clinical practitioners in eastern medicine clinics about the importance of informing their patients about regular cancer screening may be an option to boost cancer literacy and screening behaviour in Korea. © 2015 John Wiley & Sons Ltd.

  15. Delivery of propellant soluble drug from a metered dose inhaler.

    PubMed Central

    Ashworth, H L; Wilson, C G; Sims, E E; Wotton, P K; Hardy, J G

    1991-01-01

    The deposition of particulate suspensions delivered from a metered dose inhaler has been investigated extensively. The distribution of propellant, delivered from a metered dose inhaler, was studied by radiolabelling it with technetium-99m hexamethylpropyleneamine oxime. Andersen sampler measurements indicated that half of the dose was associated with particles in the size range 0.5-5 microns diameter. The preparation was administered to healthy subjects by inhalation and deposition was monitored with a gamma camera. Each lung image was divided into an inner, mid, and peripheral zone. The effects on deposition of varying the size of the delivery orifice (0.46, 0.61, and 0.76 mm internal diameters) and the effect of attaching a spacer were assessed. Lung deposition was independent of the orifice size within the actuator. Without the spacer the average dose deposited in the lungs was 39%, with 15% penetrating into the peripheral part of the lungs. Attachment of the spacer to the mouth-piece increased the mean lung deposition to 57% and reduced oropharyngeal deposition. The study has shown that propellant soluble drugs can be delivered efficiently to the lungs from a metered dose inhaler. Images PMID:2038731

  16. Fostering employee involvement.

    PubMed

    Beecher, G P

    1997-11-01

    Every year, the ODA's Economics of Practice Committee, with the help of an independent consulting firm, carries out the Cost of Practice Monitor which tracks the various costs of running a dental practice in Ontario. This article is the result of a joint ODA-Arthur Andersen initiative to provide members with detailed information from the Monitor. Over the next year, there will be a series of articles published under the heading "Best practises for Ontario's Dental Practices." The article featured in this issue focuses on wage expenses in dental practices and how to foster employee involvement as a means of addressing cost-productivity issues. Furthermore, information relating to wage expenses may be used by practitioners to benchmark their practice against the average Ontario dental practice. Appendix C was developed for this purpose. Through benchmarking, the practitioner may gain insight into ways of evaluating their practice and in addressing issues that could improve the management of the practice. For a long time, concepts of best business practises were applied only to manufacturing organizations or large multi-national corporations but experience has demonstrated that these activities are universal to all organizations, including service companies, schools, government and not-for-profit organizations.

  17. Modeling of point defects and rare gas incorporation in uranium mono-carbide

    NASA Astrophysics Data System (ADS)

    Chartier, A.; Van Brutzel, L.

    2007-02-01

    An embedded atom method (EAM) potential has been established for uranium mono-carbide. This EAM potential was fitted on structural properties of metallic uranium and uranium mono-carbide. The formation energies of point defects, as well as activation energies for self migration, have been evaluated in order to cross-check the suitability of the potential. Assuming that the carbon vacancies are the main defects in uranium mono-carbide compounds, the migration paths and energies are consistent with experimental data selected by Catlow[C.R.A. Catlow, J. Nucl. Mater. 60 (1976) 151]. The insertion and migration energies for He, Kr and Xe have also been evaluated with available inter-atomic potentials [H.H. Andersen, P. Sigmund, Nucl. Instr. and Meth. B 38 (1965) 238]. Results show that the most stable defect configuration for rare gases is within uranium vacancies. The migration energy of an interstitial Xe is 0.5 eV, in agreement with the experimental value of 0.5 eV [Hj. Matzke, Science of advanced LMFBR fuels, Solid State Physics, Chemistry and Technology of Carbides, Nitrides and Carbonitrides of Uranium and Plutonium, North-Holland, 1986].

  18. Effect of total and pair configurational entropy in determining dynamics of supercooled liquids over a range of densities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Banerjee, Atreyee; Nandi, Manoj Kumar; Bhattacharyya, Sarika Maitra, E-mail: mb.sarika@ncl.res.in

    2016-07-21

    In this paper, we present a study of supercooled liquids interacting with the Lennard Jones potential and the corresponding purely repulsive (Weeks-Chandler-Andersen) potential, over a range of densities and temperatures, in order to understand the origin of their different dynamics in spite of their structures being similar. Using the configurational entropy as the thermodynamic marker via the Adam Gibbs relation, we show that the difference in the dynamics of these two systems at low temperatures can be explained from thermodynamics. At higher densities both the thermodynamical and dynamical difference between these model systems decrease, which is quantitatively demonstrated in thismore » paper by calculating different parameters. The study also reveals the origin of the difference in pair entropy despite the similarity in the structure. Although the maximum difference in structure is obtained in the partial radial distribution function of the B type of particles, the rdf of AA pairs and AB pairs gives rise to the differences in the entropy and dynamics. This work supports the observation made in an earlier study [A. Banerjee et al., Phys. Rev. Lett. 113, 225701 (2014)] and shows that they are generic in nature, independent of density.« less

  19. Involvement of tyrosine residues, N-terminal amino acids, and beta-alanine in insect cuticular sclerotization.

    PubMed

    Andersen, Svend Olav

    2007-09-01

    During sclerotization of insect cuticle the acyldopamines, N-acetyldopamine (NADA) and N-beta-alanyldopamine (NBAD), are oxidatively incorporated into the cuticular matrix, thereby hardening and stabilizing the material by forming crosslinks between the proteins in the cuticular matrix and by forming polymers filling the intermolecular spaces in the cuticle. Sclerotized cuticle from the locust, Schistocerca gregaria, and the beetle, Tenebrio molitor, was hydrolyzed in dilute hydrochloric acid, and from the hydrolysates some components presumably degradation products of cuticular crosslinks were isolated. In two of the components, the sidechain of 3,4-dihydroxyacetophenone was linked to the amino groups of glycine and beta-alanine, respectively, and in the third component to the phenolic group of tyrosine. These three compounds, glycino-dihydroxyacetophenone, beta-alanino-dihydroxyacetophenone, and O-tyrosino-dihydroxyacetophenone, as well as the previously reported compound, lysino-dihydroxyacetophenone [Andersen, S.O., Roepstorff, P., 2007. Aspects of cuticular sclerotization in the locust, Schistocerca gregaria, and the beetle, Tenebrio molitor. Insect Biochem. Mol. Biol. 37, 223-234], are suggested to be degradation products of cuticular crosslinks, in which amino acid residues formed linkages to both the alpha- and beta-positions of the sidechain of acyldopamines.

  20. Fungal diversity and Aspergillus species in hospital environments.

    PubMed

    Martínez-Herrera, Erick Obed; Frías De-León, María Guadalupe; Duarte-Escalante, Esperanza; Calderón-Ezquerro, María Del Carmen; Jiménez-Martínez, María Del Carme; Acosta-Altamirano, Gustavo; Rivera-Becerril, Facundo; Toriello, Conchita; Reyes Montes, María Del Rocío

    2016-06-02

    Nosocomial invasive fungal infections, particularly aspergillosis, are an increasing problem in immunocompromised patients. The presented study evaluates fungal diversity and the presence of Aspergillus in air samples from two hospitals. Over the course of one year (rainy and dry seasons), the air was sampled from three areas in two hospitals (1 and 2) using a single-stage Andersen viable particle sampler (Thermo Scientific, Waltham, MA, USA). The fungi were identified by macro- and micromorphology, and the number of colony forming units (CFU)/m(3) air and their richness, abundance, and diversity were determined. Isolates Aspergillus genus were characterized by their thermotolerance. The CFU/m(3) air was similar at both hospitals during the two seasons, but different between the sampled areas. Results showed 10 fungal genera for hospital 1, and 8 for hospital 2. The most abundant were Penicillium, Cladosporium and Aspergillus. The thermotolerance test confirmed the identification of A. fumigatus section Fumigati. The highest growth rate was found in Aspergillus section Nigri. Determining the fungal diversity in the two hospitals was important because all the species have the potential to be pathogenic, especially the section Fumigati.

  1. Uranium isotopic compositions of the crust and ocean: Age corrections, U budget and global extent of modern anoxia

    NASA Astrophysics Data System (ADS)

    Tissot, François L. H.; Dauphas, Nicolas

    2015-10-01

    the variability of the 238U/235U ratio on Pb-Pb and U-Pb ages and provide analytical formulas to calculate age corrections as a function of the age and isotopic composition of the sample. The crustal ratio may be used in calculation of Pb-Pb and U-Pb ages of continental crust rocks and minerals when the U isotopic composition is unknown. In cosmochemistry, the search for 247Cm (t1/2 = 15.6 Myr), an extinct short-lived radionuclide that decays into 235U, is important for understanding how r-process nuclides were synthesized in stars and learning about the astrophysical context of solar system formation (Chen and Wasserburg, 1981; Wasserburg et al., 1996; Nittler and Dauphas, 2006; Brennecka et al., 2010b; Tissot et al., 2015). In both terrestrial and extraterrestrial samples, variations in the 238U/235U ratio affect Pb-Pb ages (and depending on the analytical protocols, U-Pb ages). Therefore, samples dated by these techniques need to have their U isotopic compositions measured (Stirling et al., 2005, 2006; Weyer et al., 2008; Amelin et al., 2010; Brennecka et al., 2010b; Brennecka and Wadhwa, 2012; Connelly et al., 2012; Goldmann et al., 2015) or uncertainties on the U isotopic composition should be propagated into age calculations. In low temperature aqueous geochemistry, U isotopic fractionation between U4+ and U6+ (driven in part by nuclear field shift effects; Bigeleisen, 1996; Schauble, 2007; Abe et al., 2008), makes U isotopes potential tracers of paleoredox conditions (Montoya-Pino et al., 2010; Brennecka et al., 2011a; Kendall et al., 2013, 2015; Asael et al., 2013; Andersen et al., 2014; Dahl et al., 2014; Goto et al., 2014; Noordmann et al., 2015). The present paper aims at constraining some aspects of the global budget of uranium in the modern oceans using 238U/235U isotope variations, which involves characterizing the U isotopic composition of seawater and several reservoirs involved in the uranium oceanic budget

  2. The Effect of Early Diagenesis on the 238U/235U Ratio of Platform Carbonates.

    NASA Astrophysics Data System (ADS)

    Tissot, F.; Chen, C.; Go, B. M.; Naziemiec, M.; Healy, G.; Swart, P. K.; Dauphas, N.

    2017-12-01

    of all ages. We find that early diagenesis results in a 0 to +0.50 ‰ offset between the δ238U of carbonates and that of seawater. [1] Teng et al (2017) RiMG 82. [2] Tissot & Dauphas (2015) GCA 167. [3] Andersen et al. (2016) Chem. Geol. 420. [4] Ku et al (1977) Deep-Sea Research 24. [5] Dunk et al (2002) Chem. Geol. 190. [6] Romaniello et al (2013) Chem. Geol. 362. [7] Andersen et al. (2014) EPSL 400.

  3. Tree ring and ice core time scales around the Santorini eruption

    NASA Astrophysics Data System (ADS)

    Löfroth, Elin; Muscheler, Raimund; Aldahan, Ala; Possnert, Göran; Berggren, Ann-Marie

    2010-05-01

    1627-1600 BC. Science 312, 548-548. Muscheler, 2009: 14C and 10Be around 1650 cal BC. In Warburton, D.A., (ed.): Time's Up! Dating the Minoan Eruption of Santorini: acts of the Minoan Eruption Chronology Workshop, Sandbjerg November 2007: Monographs of the Danish Institute at Athens. Aarhus University Press, Aarhus. 298 pp. Vinther, B.M., Clausen, H.B., Johnsen, S.J., Rasmussen, S.O., Andersen, K.K., Buchardt, S.L., Dahl-Jensen, D., Seierstad, I.K., Siggaard-Andersen, M.L., Steffensen, J.P., Svensson, A., Olsen, J., & Heinemeier, J., 2006: A synchronized dating of three Greenland ice cores throughout the Holocene. Journal of Geophysical Research-Atmospheres 111, 11.

  4. Source Identification Of Airborne Antimony On The Basis Of The Field Monitoring And The Source Profiling

    NASA Astrophysics Data System (ADS)

    Iijima, A.; Sato, K.; Fujitani, Y.; Fujimori, E.; Tanabe, K.; Ohara, T.; Shimoda, M.; Kozawa, K.; Furuta, N.

    2008-12-01

    The results of the long-term monitoring of airborne particulate matter (APM) in Tokyo indicated that APM have been extremely enriched with antimony (Sb) compared to crustal composition. This observation suggests that the airborne Sb is distinctly derived from human activities. According to the material flow analysis, automotive brake abrasion dust and fly ash from waste incinerator were suspected as the significant Sb sources. To clarify the emission sources of the airborne Sb, elemental composition, particle size distribution, and morphological profiles of dust particles collected from two possible emission sources were characterized and compared to the field observation data. Brake abrasion dust samples were generated by using a brake dynamometer. During the abrasion test, particle size distribution was measured by an aerodynamic particle sizer spectrometer. Concurrently, size- classified dust particles were collected by an Andersen type air sampler. Fly ash samples were collected from several municipal waste incinerators, and the bulk ash samples were re-dispersed into an enclosed chamber. The measurement of particle size distribution and the collection of size-classified ash particles were conducted by the same methodologies as described previously. Field observations of APM were performed at a roadside site and a residential site by using an Andersen type air sampler. Chemical analyses of metallic elements were performed by an inductively coupled plasma atomic emission spectrometry and an inductively coupled plasma mass spectrometr. Morphological profiling of the individual particle was conducted by a scanning electron microscope equipped with an energy dispersive X-ray spectrometer. High concentration of Sb was detected from both of two possible sources. Particularly, Sb concentrations in a brake abrasion dust were extremely high compared to that in an ambient APM, suggesting that airborne Sb observed at the roadside might have been largely derived from

  5. Utilization of and Adherence to Oral Contraceptive Pills and Associated Disparities in the United States: A Baseline Assessment for the Impact of the Affordable Care Act of 2010.

    PubMed

    Lin, Hsien-Chang; Lee, Hsiao-Yun

    2015-01-01

    This study investigated sociological factors that may influence women's utilization of and adherence to oral contraceptive pills. This was a retrospective cross-sectional study using the 2010-2012 Medical Expenditure Panel Survey. Female adults aged 18-50 years were included. Logistic regression was performed to discern women's decisions to use oral contraceptive pills or not. Ordinary least squares and Poisson regressions were conducted to examine the number of oral contraceptive pills received, refill frequency, and annual out-of-pocket expenditure on oral contraceptive pills. Covariates were based on the Andersen model of health care utilization. Among the study sample (weighted n = 207,007,531), 14.8% were oral contraceptive pill users. Factors positively related to oral contraceptive pill use included non-Hispanic white ethnicity, younger age, not currently married, having private insurance, residing in the Midwest, higher education level, and higher annual family income. Being non-Hispanic white and having a higher education level were positively related to oral contraceptive pill adherence. Our findings therefore demonstrate disparities in oral contraceptive pill utilization and adherence, especially according to women's race/ethnicity and educational level. This study serves as a baseline assessment for the impact of the Affordable Care Act on oral contraceptive pill utilization and adherence for future studies. © The Author(s) 2015.

  6. Predicting needs for nursing home admission - does sense of coherence delay nursing home admission in care dependent older people? A longitudinal study.

    PubMed

    Thygesen, Elin; Saevareid, Hans Inge; Lindstrom, Torill Christine; Nygaard, Harald A; Engedal, Knut

    2009-03-01

    Objectives.  This study examined predisposing, enabling and need variables (Andersen's Behavioral Model) influencing the need for nursing home admission (NHA) in older people receiving home nursing care. In particular, the potential role of coping ability, measured as 'sense of coherence' (SOC), was studied. Design, sample, and measurements.  A survey with baseline- and follow-up data after a 2-year period was undertaken with 208 patients aged 75+. The measures used were: gender, education, age, social visits, SOC, social provision scale (SPS), self-rated health (SRH), general health questionnaire (GHQ), clinical dementia rating (CDR), Barthel activities of daily living (ADL) index, and registered illnesses (RI). A Cox proportional model was used to examine factors that could explain risk of NHA. Results.  Measures with predictive properties were Barthel ADL index, SPS, SRH, and gender. SOC, along with subjective health complaints, general health questionnaire, RI and social visits did not predict NHA. Conclusions.  It is concluded that the patients' subjective evaluations of both their health and perceived social support were important predictors of future NHA needs, and should be seriously taken into consideration, along with the more commonly used objective measures of ADL and CDR. © 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd.

  7. Real-time measurements of airborne biologic particles using fluorescent particle counter to evaluate microbial contamination: results of a comparative study in an operating theater.

    PubMed

    Dai, Chunyang; Zhang, Yan; Ma, Xiaoling; Yin, Meiling; Zheng, Haiyang; Gu, Xuejun; Xie, Shaoqing; Jia, Hengmin; Zhang, Liang; Zhang, Weijun

    2015-01-01

    Airborne bacterial contamination poses a risk for surgical site infection, and routine surveillance of airborne bacteria is important. Traditional methods for detecting airborne bacteria are time consuming and strenuous. Measurement of biologic particle concentrations using a fluorescent particle counter is a novel method for evaluating air quality. The current study was to determine whether the number of biologic particles detected by the fluorescent particle counter can be used to indicate airborne bacterial counts in operating rooms. The study was performed in an operating theater at a university hospital in Hefei, China. The number of airborne biologic particles every minute was quantified using a fluorescent particle counter. Microbiologic air sampling was performed every 30 minutes using an Andersen air sampler (Pusong Electronic Instruments, Changzhou, China). Correlations between the 2 different methods were analyzed by Pearson correlation coefficients. A significant correlation was observed between biologic particle and bacterial counts (Pearson correlation coefficient = 0.76), and the counting results from 2 methods both increased substantially between operations, corresponding with human movements in the operating room. Fluorescent particle counters show potential as important tools for monitoring bacterial contamination in operating theatres. Copyright © 2015 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  8. Efficient measurement of point-to-set correlations and overlap fluctuations in glass-forming liquids

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Berthier, Ludovic; Charbonneau, Patrick; Department of Physics, Duke University, Durham, North Carolina 27708

    Cavity point-to-set correlations are real-space tools to detect the roughening of the free-energy landscape that accompanies the dynamical slowdown of glass-forming liquids. Measuring these correlations in model glass formers remains, however, a major computational challenge. Here, we develop a general parallel-tempering method that provides orders-of-magnitude improvement for sampling and equilibrating configurations within cavities. We apply this improved scheme to the canonical Kob-Andersen binary Lennard-Jones model for temperatures down to the mode-coupling theory crossover. Most significant improvements are noted for small cavities, which have thus far been the most difficult to study. This methodological advance also enables us to study amore » broader range of physical observables associated with thermodynamic fluctuations. We measure the probability distribution of overlap fluctuations in cavities, which displays a non-trivial temperature evolution. The corresponding overlap susceptibility is found to provide a robust quantitative estimate of the point-to-set length scale requiring no fitting. By resolving spatial fluctuations of the overlap in the cavity, we also obtain quantitative information about the geometry of overlap fluctuations. We can thus examine in detail how the penetration length as well as its fluctuations evolve with temperature and cavity size.« less

  9. Bioinformatic analysis of the nucleolus.

    PubMed

    Leung, Anthony K L; Andersen, Jens S; Mann, Matthias; Lamond, Angus I

    2003-12-15

    The nucleolus is a plurifunctional, nuclear organelle, which is responsible for ribosome biogenesis and many other functions in eukaryotes, including RNA processing, viral replication and tumour suppression. Our knowledge of the human nucleolar proteome has been expanded dramatically by the two recent MS studies on isolated nucleoli from HeLa cells [Andersen, Lyon, Fox, Leung, Lam, Steen, Mann and Lamond (2002) Curr. Biol. 12, 1-11; Scherl, Coute, Deon, Calle, Kindbeiter, Sanchez, Greco, Hochstrasser and Diaz (2002) Mol. Biol. Cell 13, 4100-4109]. Nearly 400 proteins were identified within the nucleolar proteome so far in humans. Approx. 12% of the identified proteins were previously shown to be nucleolar in human cells and, as expected, nearly all of the known housekeeping proteins required for ribosome biogenesis were identified in these analyses. Surprisingly, approx. 30% represented either novel or uncharacterized proteins. This review focuses on how to apply the derived knowledge of this newly recognized nucleolar proteome, such as their amino acid/peptide composition and their homologies across species, to explore the function and dynamics of the nucleolus, and suggests ways to identify, in silico, possible functions of the novel/uncharacterized proteins and potential interaction networks within the human nucleolus, or between the nucleolus and other nuclear organelles, by drawing resources from the public domain.

  10. [The Bambuí Project: a population-based study of factors associated with regular utilization of dental services in adults].

    PubMed

    Matos, D L; Lima-Costa, M F; Guerra, H L; Marcenes, W

    2001-01-01

    A cross-sectional study was conducted in Bambuí, Minas Gerais, to identify factors associated with regular use of dental services. Participants were interviewed with a structured questionnaire and previously validated questions. 999/1,221 (81.8%) randomly selected individuals aged > 18 years participated in the Bambuí dental survey. Of these, 654 out of 656 individuals who had at least one natural tooth and had visited a dentist during their lifetime participated in the study. Results adjusted by multiple logistic regression showed that regular use of dental services was significantly related to having > 8 and 4-7 years of schooling (OR = 9.90; 95% CI = 2.90-33.77 and OR = 3.87; 95% CI = 1.11-13.51, respectively), having a preference for restorative treatment rather than extraction (OR = 4.91; 95% CI = 2.23-10.79), having no present need of dental treatment (OR = 4.87; 95% CI = 3.17-7.49), and belief that visiting the dentist prevents tooth decay and gum disease (OR = 1.73; 95% CI = 1.13-2.65). The results show that regular use of dental services was related to factors distributed in the Andersen and Newman model (1973) explaining use of dentistry services.

  11. Barriers and Facilitators to Adoption of Genomic Services for Colorectal Care within the Veterans Health Administration.

    PubMed

    Sperber, Nina R; Andrews, Sara M; Voils, Corrine I; Green, Gregory L; Provenzale, Dawn; Knight, Sara

    2016-04-28

    We examined facilitators and barriers to adoption of genomic services for colorectal care, one of the first genomic medicine applications, within the Veterans Health Administration to shed light on areas for practice change. We conducted semi-structured interviews with 58 clinicians to understand use of the following genomic services for colorectal care: family health history documentation, molecular and genetic testing, and genetic counseling. Data collection and analysis were informed by two conceptual frameworks, the Greenhalgh Diffusion of Innovation and Andersen Behavioral Model, to allow for concurrent examination of both access and innovation factors. Specialists were more likely than primary care clinicians to obtain family history to investigate hereditary colorectal cancer (CRC), but with limited detail; clinicians suggested templates to facilitate retrieval and documentation of family history according to guidelines. Clinicians identified advantage of molecular tumor analysis prior to genetic testing, but tumor testing was infrequently used due to perceived low disease burden. Support from genetic counselors was regarded as facilitative for considering hereditary basis of CRC diagnosis, but there was variability in awareness of and access to this expertise. Our data suggest the need for tools and policies to establish and disseminate well-defined processes for accessing services and adhering to guidelines.

  12. Factors related to severe untreated tooth decay in rural adolescents: a case-control study for public health planning.

    PubMed

    Skaret, E; Weinstein, P; Milgrom, P; Kaakko, T; Getz, T

    2004-01-01

    In this case-control study of rural adolescents we identified factors to discriminate those who have high levels of tooth decay and receive treatment from those with similar levels who receive no treatment. The sample was drawn from all 12-20-year-olds (n = 439) in a rural high school in Washington State, U.S. The criterion for being included was 5 or more decayed, missing or filled teeth. The questionnaire included structure, history, cognition and expectation variables based on a model by Grembowski, Andersen and Chen. No structural variable was related to the dependent variable. Two of 10 history variables were related: perceived poor own dental health and perceived poor mother's dental health. Four of eight cognition variables were also predictive: negative beliefs about the dentist, not planning to go to a dentist even if having severe problems, not being in any club or playing on a sports team and not having a best friend. No relationship was found for the expectation variable 'usual source of care'. These data are consistent with the hypothesis that untreated tooth decay is associated with avoidance of care and point to the importance of history and cognition variables in planning efforts to improve oral health of rural adolescents.

  13. Exploring the association of dental care utilization with oral impacts on daily performances (OIDP) - a prospective study of ageing people in Norway and Sweden.

    PubMed

    Gülcan, Ferda; Ekbäck, Gunnar; Ordell, Sven; Klock, Kristin S; Lie, Stein Atle; Åstrøm, Anne Nordrehaug

    2018-01-01

    To explore the association of dental health care utilization with oral impacts on daily performances (OIDP) across time focusing ageing Norwegian and Swedish adults adjusting for predisposing, enabling, and need related-factors as defined by Andersen's model. Data were based on Norwegian and Swedish 1942 birth-cohorts conducted in 2007 (age 65) and 2012 (age 70). In Norway, the response rates ranged from 54% to 58%. Corresponding figures in Sweden were from 72% to 73%. Self-administered questionnaires assessed OIDP, dental care utilization and predisposing, enabling and need related factors. Logistic regression with robust variance estimation was used to adjust for clustering in repeated data. Significant covariates of OIDP were satisfaction with dental services, dental care avoidance due to financial constraints, frightening experience with dental care during childhood and patient initiated dental visiting. Frequency and regularity of dental attendance were associated with OIDP in the Swedish cohort, only. In spite of country differences in the public co-financing of dental care, dental care utilization indicators were associated with OIDP across time in both cohorts. Encouraging regular and dentist initiated visiting patterns and strengthening beliefs in keeping own teeth could be useful in attempts to reduce poor oral health related quality of life in ageing people.

  14. Expression of a Mutant kcnj2 Gene Transcript in Zebrafish

    PubMed Central

    Leong, Ivone U. S.; Skinner, Jonathan R.; Shelling, Andrew N.; Love, Donald R.

    2013-01-01

    Long QT 7 syndrome (LQT7, also known as Andersen-Tawil syndrome) is a rare autosomal-dominant disorder that causes cardiac arrhythmias, periodic paralysis, and dysmorphic features. Mutations in the human KCNJ2 gene, which encodes for the subunit of the potassium inwardly-rectifying channel (IK1), have been associated with the disorder. The majority of mutations are considered to be dominant-negative as mutant proteins interact to limit the function of wild type KCNJ2 proteins. Several LQT7 syndrome mouse models have been created that vary in the physiological similarity to the human disease. To complement the LQT7 mouse models, we investigated the usefulness of the zebrafish as an alternative model via a transient approach. Initial bioinformatic analysis identified the zebrafish orthologue of the human KCNJ2 gene, together with a spatial expression profile that was similar to that of human. The expression of a kcnj2-12 transcript carrying an in-frame deletion of critical amino acids identified in human studies resulted in embryos that exhibited defects in muscle development, thereby affecting movement, a decrease in jaw size, pupil-pupil distance, and signs of scoliosis. These defects correspond to some phenotypes expressed by human LQT7 patients. PMID:27335675

  15. On size-constrained minimum s–t cut problems and size-constrained dense subgraph problems

    DOE PAGES

    Chen, Wenbin; Samatova, Nagiza F.; Stallmann, Matthias F.; ...

    2015-10-30

    In some application cases, the solutions of combinatorial optimization problems on graphs should satisfy an additional vertex size constraint. In this paper, we consider size-constrained minimum s–t cut problems and size-constrained dense subgraph problems. We introduce the minimum s–t cut with at-least-k vertices problem, the minimum s–t cut with at-most-k vertices problem, and the minimum s–t cut with exactly k vertices problem. We prove that they are NP-complete. Thus, they are not polynomially solvable unless P = NP. On the other hand, we also study the densest at-least-k-subgraph problem (DalkS) and the densest at-most-k-subgraph problem (DamkS) introduced by Andersen andmore » Chellapilla [1]. We present a polynomial time algorithm for DalkS when k is bounded by some constant c. We also present two approximation algorithms for DamkS. In conclusion, the first approximation algorithm for DamkS has an approximation ratio of n-1/k-1, where n is the number of vertices in the input graph. The second approximation algorithm for DamkS has an approximation ratio of O (n δ), for some δ < 1/3.« less

  16. Demonstrating successful aging using the International Collaborative Study for Oral Health Outcomes.

    PubMed

    Atchison, K A; Andersen, R M

    2000-01-01

    As the lifespan increases and people are faced with 15 to 20 years of "old age," we ask what one considers successful aging with respect to oral health. We propose a comprehensive combination of outcome variables, maintenance of teeth, manageable periodontal condition, positive perceived oral health, satisfaction with their access to and receipt of dental services, and minimal functional problems, that together comprise a definition of successful aging. The International Collaborative Study for Oral Health Outcomes provides a data set for exploring the oral health of a diverse sample of older adults in US and international sites using the modified Andersen Behavioral Model. The percent of adults who report no natural teeth ranged from 16 percent in San Antonio to 59 percent in New Zealand. Seventy percent or more of the adults from each site rated their oral health as good/fair or better except in Poland. The current cohort of older adults is faring better on some indicators than others; nevertheless, ethnic minorities and poorer countries still demonstrate inequities. Dentistry must attempt to educate individuals early in their lifespan that a combination of personal oral health practices and current dental techniques offers the potential for successful oral health throughout one's lifetime.

  17. Is religion the forgotten variable in maternal and child health? Evidence from Zimbabwe.

    PubMed

    Ha, Wei; Salama, Peter; Gwavuya, Stanley; Kanjala, Chifundo

    2014-10-01

    The Apostolic faith, a rapidly growing and increasingly influential force in Zimbabwe, has received attention in the literature due to its potential role in shaping its followers' attitudes and behaviours towards health. Existing literature, however, has only examined small cross-section samples from a few confined survey sites or has failed to adequately control for the many factors that may mediate the effects of religion. This paper examines the effects of the Apostolic faith on the usage of maternal health and child immunization services in Zimbabwe. It is based on a nationally representative sample from the 2009 Multi-Indicator Monitoring Survey and employs the established Andersen model on access to health services. Well controlled multivariate logit regression models derived from these data show that an affiliation with the Apostolic faith is a substantial and significant risk factor in reducing the utilization of both maternal and child health services. Moreover, even when the services were least costly and readily available and when gaps along other social and economic factors were limited, as in the case of Bacillus Calmette-Guérin vaccination and one visit to antenatal care, women and children from Apostolic faith families still fared significantly worse than others in accessing them. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. Aerosolization properties, surface composition and physical state of spray-dried protein powders.

    PubMed

    Bosquillon, Cynthia; Rouxhet, Paul G; Ahimou, François; Simon, Denis; Culot, Christine; Préat, Véronique; Vanbever, Rita

    2004-10-19

    Powder aerosols made of albumin, dipalmitoylphosphatidylcholine (DPPC) and a protein stabilizer (lactose, trehalose or mannitol) were prepared by spray-drying and analyzed for aerodynamic behavior, surface composition and physical state. The powders exited a Spinhaler inhaler as particle aggregates, the size of which depending on composition, spray-drying parameters and airflow rate. However, due to low bulk powder tap density (<0.15 g/cm3), the aerodynamic size of a large fraction of aggregates remained respirable (<5 microm). Fine particle fractions ranged between 21% and 41% in an Andersen cascade impactor operated at 28.3 l/min, with mannitol and lactose providing the most cohesive and free-flowing powders, respectively. Particle surface analysis by X-ray photoelectron spectroscopy (XPS) revealed a surface enrichment with DPPC relative to albumin for powders prepared under certain spray-drying conditions. DPPC self-organized in a gel phase in the particle and no sugar or mannitol crystals were detected by X-ray diffraction. Water sorption isotherms showed that albumin protected lactose from moisture-induced crystallization. In conclusion, a proper combination of composition and spray-drying parameters allowed to obtain dry powders with elevated fine particle fractions (FPFs) and a physical environment favorable to protein stability.

  19. Generating monodisperse pharmacological aerosols using the spinning-top aerosol generator.

    PubMed

    Biddiscombe, Martyn F; Barnes, Peter J; Usmani, Omar S

    2006-01-01

    Pharmacological aerosols of precisely controlled particle size and narrow dispersity can be generated using the spinning-top aerosol generator (STAG). The ability of the STAG to generate monodisperse aerosols from solutions of raw drug compounds makes it a valuable research instrument. In this paper, the versatility of this instrument has been further demonstrated by aerosolizing a range of commercially available nebulized pulmonary therapy preparations. Nebules of Flixotide (fluticasone propionate), Pulmicort (budesonide), Combivent (salbutamol sulphate and ipratropium bromide), Bricanyl (terbutaline sulphate), Atrovent(ipratropium bromide), and Salamol (salbutamol sulphate) were each mixed with ethanol and delivered to the STAG. Monodisperse drug aerosol distributions were generated with MMADs of 0.95-6.7 microm. To achieve larger particle sizes from the nebulizer drug suspensions, the STAG formed compound particle agglomerates derived from the smaller insoluble drug particles. These compound agglomerates behaved aerodynamically as a single particle, and this was verified using an aerodynamic particle sizer and an Andersen Cascade Impactor. Scanning electron microscope images demonstrated their physical structure. On the other hand using the nebulizer drug solutions, spherical particles proportional to the original droplet diameter were generated. The aerosols generated by the STAG can allow investigators to study the scientific principles of inhaled drug deposition and lung physiology for a range of therapeutic agents.

  20. [Coal fineness effect on primary particulate matter features during pulverized coal combustion].

    PubMed

    Lü, Jian-yi; Li, Ding-kai

    2007-09-01

    Three kinds of coal differed from fineness were burned in a laboratory-scale drop tube furnace for combustion test, and an 8-stage Andersen particle impactor was employed for sampling the primary particulate matter (PM), in order to study coal fineness effect on primary PM features during pulverized coal combustion. It has been shown that the finer the coal was, the finer the PM produced. PM, emission amount augmented with coal fineness decreased, and the amount of PM10 increased from 13 mg/g to 21 mg/g respectively generated by coarse coal and fine coal. The amount of PM2.5 increased from 2 mg/g to 8 mg/g at the same condition. Constituents and content in bulk ash varied little after three different fineness coal combustion, while the appearance of grading PM differed visibly. The value of R(EE) increased while the coal fineness deceased. The volatility of trace elements which were investigated was Pb > Cr > Zn > Cu > Ni in turn. The concentration of poisonous trace elements was higher which generated from fine coal combustion. The volatilization capacity was influenced little by coal fineness, but the volatilization extent was influenced differently by coal fineness. Fine coal combustion affects worse environment than coarse coal does.

  1. A unifying framework of the demand for transnational medical travel.

    PubMed

    Osterle, August; Johnson, Tricia; Delgado, Jose

    2013-01-01

    Transnational medical travel has gained attention recently as a strategy for patients to obtain care that is higher quality, costs less, or offers improved access relative to care provided within their home countries. This article examines institutional environments in the European Union and United States that influence transnational medical travel, describes the conceptual model of demand for medical travel, and illustrates individual dimensions in the conceptual model of medical travel using a series of case studies. The conceptual model of medical travel is predicated on Andersen's behavioral model of health services. Transnational medical travel is a heterogeneous phenomenon that is influenced by a number of patient-related factors and by the institutional environment in which the patient resides. While cost, access, and quality are commonly cited factors that influence a patient's decision regarding where to seek care, multiple factors may simultaneously influence the decision about the destination for care, including culture, social factors, and the institutional environment. The conceptual framework addresses the patient-related factors that influence where a patient seeks care. This framework can help researchers and regulatory bodies to evaluate the opportunities and the risks of transnational medical travel and help providers and governments to develop international patient programs.

  2. Fine particulate pollution in the Nanjing northern suburb during summer: composition and sources.

    PubMed

    An, Junlin; Duan, Qing; Wang, Honglei; Miao, Qing; Shao, Ping; Wang, Jian; Zou, Jianan

    2015-09-01

    To understand the chemical composition characteristic of pollution in a northern suburb of Nanjing, particle samples were collected by two Andersen cascade impactors from May to July 2013. The positive matrix factorization version 3 (EPA-PMF 3.0) was applied to identify the source contribution of PM2.1 concentrations in the study area. Source categories were determined based on the chemical component abundances in the source profiles. Overall, results indicated that seven factors were obtained. The factors are identified as follows: (I) secondary aerosol, characterized by high concentrations of NH4 (+), NO3 (-), and SO4 (2-), accounting for 20.22 %; (II) metallurgical aerosol, characterized by high concentrations of Pb, Cd, and Zn, accounting for 6.71 %; (III) road dust, characterized by high concentrations of Mg, Ca, Na, Al, and Ba, accounting for 11.85 %; (IV) biomass burning, characterized by high concentrations of K(+), Na(+), Cl(-), and K, accounting for 10.17 %; (V) residual oil, characterized by high concentrations of V and Cr, accounting for 16.63 %; (VI) iron and steel industry, characterized by high concentrations of Mn and Fe, accounting for 9.48 %; and (VII) vehicle exhaust, characterized by high concentrations of organic carbon (OC), Mo, elemental carbon (EC) and K, accounting for 24.94 %.

  3. Sampling and data handling methods for inhalable particulate sampling. Final report nov 78-dec 80

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, W.B.; Cushing, K.M.; Johnson, J.W.

    1982-05-01

    The report reviews the objectives of a research program on sampling and measuring particles in the inhalable particulate (IP) size range in emissions from stationary sources, and describes methods and equipment required. A computer technique was developed to analyze data on particle-size distributions of samples taken with cascade impactors from industrial process streams. Research in sampling systems for IP matter included concepts for maintaining isokinetic sampling conditions, necessary for representative sampling of the larger particles, while flowrates in the particle-sizing device were constant. Laboratory studies were conducted to develop suitable IP sampling systems with overall cut diameters of 15 micrometersmore » and conforming to a specified collection efficiency curve. Collection efficiencies were similarly measured for a horizontal elutriator. Design parameters were calculated for horizontal elutriators to be used with impactors, the EPA SASS train, and the EPA FAS train. Two cyclone systems were designed and evaluated. Tests on an Andersen Size Selective Inlet, a 15-micrometer precollector for high-volume samplers, showed its performance to be with the proposed limits for IP samplers. A stack sampling system was designed in which the aerosol is diluted in flow patterns and with mixing times simulating those in stack plumes.« less

  4. Sexual Minority Women's Satisfaction with Health Care Providers and State-level Structural Support: Investigating the Impact of Lesbian, Gay, Bisexual, and Transgender Nondiscrimination Legislation.

    PubMed

    Baldwin, Aleta M; Dodge, Brian; Schick, Vanessa; Sanders, Stephanie A; Fortenberry, J Dennis

    Structural discrimination is associated with negative health outcomes among sexual minority populations. Recent changes to state-level and national legislation provide both the opportunity and the need to further explore the impact of legislation on the health indicators of sexual minorities. Using an ecosocial theory lens, the present research addresses the relationship between structural support or discrimination and satisfaction with one's health care provider among sexual minority women. Data were drawn from an online survey of sexual minority women's health care experiences. Using the Andersen Behavioral Model of Health Services Utilization to operationalize the variables in our model, we examined the relationship between state-level nondiscrimination legislation and satisfaction with provider-a widely used measure of health care quality-through regression analysis. Participants in structurally supportive states (i.e., those with nondiscrimination legislation) were more likely to disclose their sexual identity to their providers and to report higher satisfaction with their providers. The absence of nondiscrimination legislation was associated negatively with satisfaction with providers. Results of our study show that the external environment in which sexual minority women seek health care, characterized by structural support or lack thereof, is related to perceived quality of health care. Copyright © 2017 Jacobs Institute of Women's Health. Published by Elsevier Inc. All rights reserved.

  5. Predictors of Healthcare Service Utilization for Mental Health Reasons

    PubMed Central

    Fleury, Marie-Josée; Ngamini Ngui, André; Bamvita, Jean-Marie; Grenier, Guy; Caron, Jean

    2014-01-01

    This study was designed to identify: (1) predictors of 12-month healthcare service utilization for mental health reasons, framed by the Andersen model, among a population cohort in an epidemiological catchment area; and (2) correlates associated with healthcare service utilization for mental health reasons among individuals with and without mental disorders respectively. Analyses comprised univariate, bivariate, and multiple regression analyses. Being male, having poor quality of life, possessing better self-perception of physical health, and suffering from major depressive episodes, panic disorder, social phobia, and emotional problems predicted healthcare service utilization for mental health reasons. Among individuals with mental disorders, needs factors (psychological distress, impulsiveness, emotional problems, victim of violence, and aggressive behavior) and visits to healthcare professionals were associated with healthcare service utilization for mental health reasons. Among individuals without mental disorders, healthcare service utilization for mental health reasons is strongly associated with enabling factors such as social support, income, environmental variables, and self-perception of the neighborhood. Interventions facilitating social cohesion and social solidarity in neighborhood settings may reduce the need to seek help among individuals without mental disorders. Furthermore, in their capacity as frontline professionals, general practitioners should be more sensitive in preventing, detecting, and treating mental disorders in routine primary care. PMID:25321874

  6. [Displaced people's healthcare use in Bucaramanga, Colombia].

    PubMed

    Ruiz-Rodríguez, Myriam; López-Moreno, Sergio; Avila-Burgos, Leticia; Acosta-Ramírez, Naydú

    2006-01-01

    Analysing the factors and barriers associated with the population displaced by armed conflict using medical services in Bucaramanga, Colombia. Data from the "Diagnosing the health of both displaced and non-displaced populations in Bucaramanga and its metropolitan area" study, designed and executed by the Industrial University of Santander and financed by the Pan-American Health Organisation, analysed medical service use in individuals aged over 15 years. This agreed with Andersen and Newman's model and evaluated the effect of associated factors by means of multiple logistical regression. One out of each five people who became ill during the fifteen days prior to the survey had used the medical services. This percentage was smaller than that found in the Colombian population as a whole. The type of social security regime (contributory health insurance), previous service use and being from the region were associated with greater service use. Displaced people having subsidised health insurance did not present differences in service use compared to those who had no access to such insurance. The distance from dwelling to institution was another barrier against using health services (RM = 0.64; IC 0.42-0.97). There was differential medical service use amongst the displaced population, determined by their health insurance coverage and economic position.

  7. Surgical Space Suits Increase Particle and Microbiological Emission Rates in a Simulated Surgical Environment.

    PubMed

    Vijaysegaran, Praveen; Knibbs, Luke D; Morawska, Lidia; Crawford, Ross W

    2018-05-01

    The role of space suits in the prevention of orthopedic prosthetic joint infection remains unclear. Recent evidence suggests that space suits may in fact contribute to increased infection rates, with bioaerosol emissions from space suits identified as a potential cause. This study aimed to compare the particle and microbiological emission rates (PER and MER) of space suits and standard surgical clothing. A comparison of emission rates between space suits and standard surgical clothing was performed in a simulated surgical environment during 5 separate experiments. Particle counts were analyzed with 2 separate particle counters capable of detecting particles between 0.1 and 20 μm. An Andersen impactor was used to sample bacteria, with culture counts performed at 24 and 48 hours. Four experiments consistently showed statistically significant increases in both PER and MER when space suits are used compared with standard surgical clothing. One experiment showed inconsistent results, with a trend toward increases in both PER and MER when space suits are used compared with standard surgical clothing. Space suits cause increased PER and MER compared with standard surgical clothing. This finding provides mechanistic evidence to support the increased prosthetic joint infection rates observed in clinical studies. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

    PubMed

    Andersen, Line Lykke; Mørk, Nanna; Reinert, Line S; Kofod-Olsen, Emil; Narita, Ryo; Jørgensen, Sofie E; Skipper, Kristian A; Höning, Klara; Gad, Hans Henrik; Østergaard, Lars; Ørntoft, Torben F; Hornung, Veit; Paludan, Søren R; Mikkelsen, Jacob Giehm; Fujita, Takashi; Christiansen, Mette; Hartmann, Rune; Mogensen, Trine H

    2015-08-24

    Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon (IFN) production downstream of Toll-like receptor 3. Here, we describe a novel genetic etiology of HSE by identifying a heterozygous loss-of-function mutation in the IFN regulatory factor 3 (IRF3) gene, leading to autosomal dominant (AD) IRF3 deficiency by haploinsufficiency, in an adolescent female patient with HSE. IRF3 is activated by most pattern recognition receptors recognizing viral infections and plays an essential role in induction of type I IFN. The identified IRF3 R285Q amino acid substitution results in impaired IFN responses to HSV-1 infection and particularly impairs signaling through the TLR3-TRIF pathway. In addition, the R285Q mutant of IRF3 fails to become phosphorylated at S386 and undergo dimerization, and thus has impaired ability to activate transcription. Finally, transduction with WT IRF3 rescues the ability of patient fibroblasts to express IFN in response to HSV-1 infection. The identification of IRF3 deficiency in HSE provides the first description of a defect in an IFN-regulating transcription factor conferring increased susceptibility to a viral infection in the CNS in humans. © 2015 Andersen et al.

  9. Effects of studded tires on roadside airborne dust pollution in Niigata, Japan

    NASA Astrophysics Data System (ADS)

    Fukuzaki, Norio; Yanaka, Takaaki; Urushiyama, Yoshio

    Two series of dust samples, collected by Andersen impactors (denoted by AN) and low-volume air samplers (denoted by LV), were investigated with respect to roadside airborne dusts collected in two different periods in 1983. These were the periods (i) with studded tires (February and March) and (ii) without studded tires (October). Multi-element determinations of these samples were made by neutron activation analysis and atomic absorption spectrometry. The total concentration of AN in roadside air for period (i) was about three times higher than for the period without studded tires. The lithophilic elements such as Na, Al, K, Ca, Ti, Fe and Th, and component-metal elements of stud tip, W and Ta, produced a significant increase in atmospheric concentration in winter. The contribution of pavement material, one of the most interesting components of airborne particles in this study, was related to total AN and LV by the chemical element balance method. It made up only 16 percent (9.1 μgm -3) of AN in October, compared with 46 percent (70.2 μgm -3) in February. It was also observed that the atmospheric concentrations of pavement debris to total LV decreased with the distance from the road to each sampling site.

  10. Rheumatoid arthritis disease activity and disability affect the risk of serious infection events in RADIUS 1.

    PubMed

    Weaver, Arthur; Troum, Orrin; Hooper, Michele; Koenig, Andrew S; Chaudhari, Sandeep; Feng, Jingyuan; Wenkert, Deborah

    2013-08-01

    To determine whether disease activity and disability independently correlate with serious infection event (SIE) risk in a large rheumatoid arthritis (RA) cohort. The associations between SIE and Clinical Disease Activity Index (CDAI) and Health Assessment Questionnaire-Disability Index (HAQ-DI) in the Rheumatoid Arthritis Disease-Modifying Antirheumatic Drug Intervention and Utilization Study (RADIUS 1) cohort were evaluated using the Andersen-Gill model (a proportional HR model allowing > 1 event per patient). Of 4084 patients with 347 SIE, 271 patients experienced ≥ 1 SIE. A 5-unit CDAI increase and 0.4-unit HAQ-DI increase corresponded to an increase in SIE risk with and without covariate adjustments. A 5-unit CDAI increase corresponded with a 7.7% increased SIE risk (adjusted HR 1.077, 95% CI 1.044-1.112, p < 0.0001) and a 0.4-unit HAQ-DI increase with a 30.1% increased risk (adjusted HR 1.301, 95% CI 1.225-1.381, p < 0.0001). Categorical analysis showed that more severe RA activity (even after controlling for disability) and disability were associated with an increased SIE risk. Increased RA disease activity and disability were each associated with a significantly increased SIE risk in the RADIUS 1 cohort, which could not be completely accounted for by disability.

  11. Benchmarking, benchmarks, or best practices? Applying quality improvement principles to decrease surgical turnaround time.

    PubMed

    Mitchell, L

    1996-01-01

    The processes of benchmarking, benchmark data comparative analysis, and study of best practices are distinctly different. The study of best practices is explained with an example based on the Arthur Andersen & Co. 1992 "Study of Best Practices in Ambulatory Surgery". The results of a national best practices study in ambulatory surgery were used to provide our quality improvement team with the goal of improving the turnaround time between surgical cases. The team used a seven-step quality improvement problem-solving process to improve the surgical turnaround time. The national benchmark for turnaround times between surgical cases in 1992 was 13.5 minutes. The initial turnaround time at St. Joseph's Medical Center was 19.9 minutes. After the team implemented solutions, the time was reduced to an average of 16.3 minutes, an 18% improvement. Cost-benefit analysis showed a potential enhanced revenue of approximately $300,000, or a potential savings of $10,119. Applying quality improvement principles to benchmarking, benchmarks, or best practices can improve process performance. Understanding which form of benchmarking the institution wishes to embark on will help focus a team and use appropriate resources. Communicating with professional organizations that have experience in benchmarking will save time and money and help achieve the desired results.

  12. Retracing "Ondine's curse".

    PubMed

    Nannapaneni, Ravindra; Behari, Sanjay; Todd, Nicholas V; Mendelow, A David

    2005-08-01

    "Ondine's curse" is a term used to denote a rare neurological condition causing failure of automatic respiration. The patients are no longer capable of breathing spontaneously-they must consciously and voluntarily force themselves to do so. Ondine (also known as "Undine"), a mythological figure of European tradition, was a water nymph or sprite who could become human only when she fell in love with a mortal man. However, if the mortal was unfaithful to her, he was destined to forfeit his life. In the 16th century, Paracelsus coined the term "Undine" to describe the spirit that inhabited the element of water. Baron de la Motte-Fouque wrote the story of Undine in the late 18th century. It has since become a popular subject for theater productions. Jean Giraudoux, the French playwright, introduced the concept of the loss of automaticity of all functions as the "curse of Ondine." The legend was popularized in the form of the fairy tale "The Little Mermaid" by Hans Christian Andersen and as an animated motion picture by Walt Disney Productions. In this study, we look at the origins of this eponymous term, the personalities intertwined with its popularity, and its misrepresentations in the medical literature.

  13. Structure factor of liquid alkali metals using a classical-plasma reference system

    NASA Astrophysics Data System (ADS)

    Pastore, G.; Tosi, M. P.

    1984-06-01

    This paper presents calculations of the liquid structure factor of the alkali metals near freezing, starting from the classical plasma of bare ions as reference liquid. The indirect ion-ion interaction arising from electronic screening is treated by an optimized random phase approximation (ORPA), imposing physical requirements as in the original ORPA scheme developed by Weeks, Chandler and Andersen for liquids with strongly repulsive core potentials. A comparison of the results with computer simulation data for a model of liquid rubidium shows that the present approach overcomes the well-known difficulties met in applying to these metals the standard ORPA based on a reference liquid of neutral hard spheres. The optimization scheme is also shown to be equivalent to a reduction of the range of the indirect interaction in momentum space, as proposed empirically in an earlier work. Comparison with experiment for the other alkalis shows that a good overall representation of the data can be obtained for sodium, potassium and cesium, but not for lithium, when one uses a very simple form of the electron-ion potential adjusted to the liquid compressibility. The small-angle scattering region is finally examined more carefully in the light of recent data of Waseda, with a view to possible refinements of the pseudopotential model.

  14. Bioaerosol assessment in naturally ventilated historical library building with restricted personnel access.

    PubMed

    Harkawy, Aleksander; Górny, Rafał L; Ogierman, Leonard; Wlazło, Agnieszka; Ławniczek-Wałczyk, Anna; Niesler, Anna

    2011-01-01

    The aim of this study was to check the degree and identify the sources of microbial contamination of the Jasna Gora (Bright Hill) monastery library 10 years after disinfection of the incunabula collection. The registered maximum viable indoor microbial concentrations were 1,875 and 7,100 cfu/m³ for stationary and personal measurements, whereas respective total concentrations were 71,000 and 100,000 counts/m3. There was no statistically significant difference between the concentrations of viable microorganisms measured in the stationary using Andersen, GSP, and Button samplers. Moreover, GSP and Button samplers can be interchangeably applied when viable or total microbial levels are stationary or personally measured. The culturable microorganisms constituted 0.5 - 3.9% of the total microflora only. Filamentous fungi were the most prevalent outdoors, whereas Gram-positive cocci and endospore forming Gram-positive rods dominated indoors in the air and settled dust, respectively. Hence, an unrestrained infiltration of ambient air through the draughtiness of the building envelope is probably the main process responsible for indoor fungal pollution, whereas bacterial contaminants have their major sources in the indoor environment. Moreover, even a chemically cleansed library collection, having a restricted personnel access, but under the influence of ambient air, can undergo microbial contamination and becomes an important microbial emission source.

  15. Effect of gold nanoparticles on structure and dynamics of binary Lennard-Jones liquid: Wave-vector space analysis

    NASA Astrophysics Data System (ADS)

    Separdar, L.; Davatolhagh, S.

    2016-12-01

    Molecular dynamics simulations at constant (N , V , T) are used to study the mutual effects of gold nanoparticles on the structure and dynamics of Kob-Andersen binary Lennard-Jones (BLJ) liquid within the framework of mode coupling theory of dynamic glass transition in the reciprocal space. The results show the 'softening' effect of the gold nanoparticles on the liquid dynamics in terms of (i) reducing the mode coupling crossover temperature Tc with respect to that of the bulk BLJ (i.e. BLJ without nanoparticles), (ii) decreasing the time interval of β-relaxation, and (iii) decreasing the exponent γ characterizing the power-law behavior of the α-relaxation time. This softening effect is explained in terms of the van der Waals attraction between the gold atoms comprising the nanoparticle and the BLJ host atoms, such that adsorption of host atoms onto the nanoparticle surface creates more space or free-volume for the other atoms to diffuse. By the same token interactions of purely excluded-volume-type are expected to result in the opposite effect. It is also noted that, much unlike BLJ host particles, the dynamics of gold nanoparticles is much less dependent on the wave-vector and that it exhibits a nearly exponential behavior in the α-relaxation regime.

  16. Dispersal, isolation and diversification with continued gene flow in an Andean tropical dry forest.

    PubMed

    Toby Pennington, R; Lavin, Matt

    2017-07-01

    The Andes are the world's longest mountain chain, and the tropical Andes are the world's richest biodiversity hot spot. The origin of the tropical Andean cordillera is relatively recent because the elevation of the mountains was relatively low (400-2500 m palaeoelevations) only 10 MYA with final uplift being rapid. These final phases of the Andean orogeny are thought to have had a fundamental role in shaping processes of biotic diversification and biogeography, with these effects reaching far from the mountains themselves by changing the course of rivers and deposition of mineral-rich Andean sediments across the massive Amazon basin. In a recent issue of Molecular Ecology, Oswald, Overcast, Mauck, Andersen, and Smith (2017) investigate the biogeography and diversification of bird species in the Andes of Peru and Ecuador. Their study is novel in its focus on tropical dry forests (Figure 1) rather than more mesic biomes such as rain forests, cloud forests and paramos, which tend to be the focus of science and conservation in the Andean hot spot. It is also able to draw powerful conclusions via the first deployment of genomic approaches to a biogeographic question in the threatened dry forests of the New World. © 2017 John Wiley & Sons Ltd.

  17. Predisposing, enabling, and need factors associated with utilization of institutional delivery services: A community-based cross-sectional study in far-western Nepal.

    PubMed

    Freidoony, Leila; Ranabhat, Chhabi Lal; Kim, Chun-Bae; Kim, Chang-Soo; Ahn, Dong-Won; Doh, Young Ah

    2018-01-01

    Use of institutional delivery services can be effective in reducing maternal and infant mortality. In Nepal, however, the majority of women deliver at home. Using Andersen's behavioral model of use of health care services, this cross-sectional study aimed to identify factors associated with use of institutional delivery services in four villages and one municipality in Kailali district, Nepal. Mothers (N = 500) who had given birth in the 5 years preceding the survey (conducted between January and February 2015) were randomly selected by cluster sampling and interviewed using a semi-structured questionnaire. Bivariate analyses and multivariate hierarchical logistic regression analyses were performed. Among the women surveyed, 65.6% had used institutional delivery services for their last delivery, a higher proportion than the national average. Primiparity, having a secondary or higher education level, living in the Durgauli village, having husbands with occupations other than agriculture or professional/technical jobs, and having attended four or more antenatal care (ANC) visits had significantly increased use of institutional deliveries. Also, belonging to the richest 20% of the community and having experienced pregnancy complications were marginally significantly associated. These findings demonstrate the need for improving mother's education, encouraging them to attend ANC visits and addressing disparities between different regions.

  18. Immunochemical quantitation, size distribution, and cross-reactivity of lepidoptera (moth) aeroallergens in southeastern Minnesota

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wynn, S.R.; Swanson, M.C.; Reed, C.E.

    1988-07-01

    With an immunochemical method, we analyzed outdoor air samples during a 3-year period for concentrations of the predominant local species of moth, Pseudaletia unipuncta (Haworth). Airborne particulates were collected on fiberglass filter sheets with an Accu-Vol sampler located 1.5 m above ground on the southeastern Minnesota prairie. Filter eluates analyzed by RIA inhibition contained concentrations of moth protein peaking in June and August to September of each year, with levels comparable to reported immunochemically measured levels of pollen and mold allergens. These peaks also corresponded with total numbers of moths captured in light traps. Moth-allergen activity was distributed in particlemore » sizes ranging from 0.8 to greater than 4.1 micron when sized samples were obtained by use of an Andersen cascade impaction head. By RIA inhibition, there was cross-reactivity between P. unipuncta and insects of different genera, families, and orders, but not with pollens or molds. Forty-five percent of 257 patients with immediate positive skin tests to common aeroallergens had positive skin tests to one or more commercially available whole body insect extracts. Of 120 patients with allergic rhinitis believed to be primarily caused by ragweed sensitivity, 5% also had elevated specific IgE to moths. We conclude that airborne concentrations of Lepidoptera can be measured immunochemically and that moths may be a seasonal allergen in the United States.« less

  19. Spatial correlation of the dynamic propensity of a glass-forming liquid

    NASA Astrophysics Data System (ADS)

    Razul, M. Shajahan G.; Matharoo, Gurpreet S.; Poole, Peter H.

    2011-06-01

    We present computer simulation results on the dynamic propensity (as defined by Widmer-Cooper et al 2004 Phys. Rev. Lett. 93 135701) in a Kob-Andersen binary Lennard-Jones liquid system consisting of 8788 particles. We compute the spatial correlation function for the dynamic propensity as a function of both the reduced temperature T, and the time scale on which the particle displacements are measured. For T <= 0.6, we find that non-zero correlations occur at the largest length scale accessible in our system. We also show that a cluster-size analysis of particles with extremal values of the dynamic propensity, as well as 3D visualizations, reveal spatially correlated regions that approach the size of our system as T decreases, consistently with the behavior of the spatial correlation function. Next, we define and examine the 'coordination propensity', the isoconfigurational average of the coordination number of the minority B particles around the majority A particles. We show that a significant correlation exists between the spatial fluctuations of the dynamic and coordination propensities. In addition, we find non-zero correlations of the coordination propensity occurring at the largest length scale accessible in our system for all T in the range 0.466 < T < 1.0. We discuss the implications of these results for understanding the length scales of dynamical heterogeneity in glass-forming liquids.

  20. Social Support and Health Service Use in Depressed Adults: Findings From the National Health and Nutrition Examination Survey.

    PubMed

    Andrea, Sarah B; Siegel, Sarah A R; Teo, Alan R

    2016-01-01

    We investigated the relationship between social support and health service use among men and women with depression. Participants were 1379 adults with symptoms of depression (Patient Health Questionnaire-9 score ≥ 5) in the National Health and Nutrition Examination Survey. Using the framework of the Andersen Behavioral Model of Health Services Use, multivariable regression models used social support, stratified by depression severity, to estimate association with utilization of mental health and nonmental health services. Partial F-tests examined a priori interactions between social support and gender. Among those with adequate social support, odds of seeing a nonmental health provider were much higher when depression was moderate [Odds Ratio (OR): 2.6 (1.3-5.3)] or severe [OR: 3.2 (1.2-8.7)], compared to those lacking social support. Conversely, odds of mental health service use were 60% lower among those with moderate depression [OR: 0.4 (0.2-1.0)] when social support was adequate as opposed to inadequate. Social support was unrelated to service use when depression was mild. Gender moderated the relationship between social support and health service use among individuals with severe depression. Social support has opposite associations with mental and nonmental health service use among adults with clinically significant depression. This association is largely attributable to the effect of male gender on the relationship between social support and health service use. Published by Elsevier Inc.

  1. Intermolecular interactions and the thermodynamic properties of supercritical fluids.

    PubMed

    Yigzawe, Tesfaye M; Sadus, Richard J

    2013-05-21

    The role of different contributions to intermolecular interactions on the thermodynamic properties of supercritical fluids is investigated. Molecular dynamics simulation results are reported for the energy, pressure, thermal pressure coefficient, thermal expansion coefficient, isothermal and adiabatic compressibilities, isobaric and isochoric heat capacities, Joule-Thomson coefficient, and speed of sound of fluids interacting via both the Lennard-Jones and Weeks-Chandler-Andersen potentials. These properties were obtained for a wide range of temperatures, pressures, and densities. For each thermodynamic property, an excess value is determined to distinguish between attraction and repulsion. It is found that the contributions of intermolecular interactions have varying effects depending on the thermodynamic property. The maxima exhibited by the isochoric and isobaric heat capacities, isothermal compressibilities, and thermal expansion coefficient are attributed to interactions in the Lennard-Jones well. Repulsion is required to obtain physically realistic speeds of sound and both repulsion and attraction are necessary to observe a Joule-Thomson inversion curve. Significantly, both maxima and minima are observed for the isobaric and isochoric heat capacities of the supercritical Lennard-Jones fluid. It is postulated that the loci of these maxima and minima converge to a common point via the same power law relationship as the phase coexistence curve with an exponent of β = 0.32. This provides an explanation for the terminal isobaric heat capacity maximum in supercritical fluids.

  2. Characterization of airborne particles at a high-btu coal-gasification pilot plant.

    PubMed

    Davidson, C I; Santhanam, S; Stetter, J R; Flotard, R D; Gebert, E

    1982-12-01

    Airborne particles in fugitive emissions have been measured at a slagging fixed-bed coal-gasification pilot plant using lignite. Sampling was conducted during shutdown operations and opening of the gasifier following an aborted startup. Aerosol collected with a Sierra high-volume impactor was subjected to analysis by gas chromatography, mass spectrometry, and scanning electron microscopy; aerosol collected with an Andersen low-volume impactor was subjected to flameless atomic absorption analysis. The data show that the bulk of the trace organic material is associated with small particles: these data are similar to data on ambient air reported in the literature. Particle morphologies resemble those of fly ash from coal combustion, including smooth spheres, vesicular spheres, and crystalline material. Trace element size distributions are bimodal and resemble data for ambient air. Pb-containing particles are generally submicron, while particles containing Al, Fe, and other crustal species are mostly of supermicron size. Aluminum-based aerosol enrichment factors calculated from the lignite composition show that the composition of the aerosol resembles that of the coal, with the exception of modest enrichments of Mg, Na, As, and Pb in the submicron size range. Aerosol enrichment factors based on the earth's crustal composition are somewhat greater than those based on coal composition for several elements, suggesting potential errors in using crustal enrichment data to investigate chemical fractionation during aerosol formation.

  3. Study of water-oil emulsion combustion in large pilot power plants for fine particle matter emission reduction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Allouis, C.; Beretta, F.; L'Insalata, A.

    2007-04-15

    The combustion of heavy fuel oil for power generation is a great source of carbonaceous and inorganic particle emissions, even though the combustion technologies and their efficiency are improving. The information about the size distribution function of the particles originated by trace metals present into the fuels is not adequate. In this paper, we focused our attention the influence of emulsion oil-water on the larger distribution mode of both the carbonaceous and metallic particles. Isokinetic sampling was performed at the exhausts of flames of a low-sulphur content heavy oil and its emulsion with water produced in two large pilot plants.more » The samples were size-segregated by mean of an 8-stages Andersen impactor. Further investigation performed on the samples using electronic microscopy (SEM) coupled with X-ray analysis (EDX) evidenced the presence of solid spherical particles, plerosphere, with typical dimensions ranging between 200 nm and 2-3 {mu}m, whose atomic composition contains a large amount of the trace metals present in the parent oils (Fe, V, Ni, etc.). EDX analyses revealed that the metal concentration increases as the plerosphere dimension decreases. We also observed that the use of emulsion slightly reduce the emission of fine particles (D{sub 50} < 8 {mu}m) in the large scale plant. (author)« less

  4. Preparation, In Vitro Characterization, and In Vivo Pharmacokinetic Evaluation of Respirable Porous Microparticles Containing Rifampicin

    PubMed Central

    Kundawala, Aliasgar; Patel, Vishnu; Patel, Harsha; Choudhary, Dhaglaram

    2014-01-01

    Abstract This study aimed to prepare and evaluate rifampicin microparticles for the lung delivery of rifampicin as respirable powder. The microparticles were prepared using chitosan by the spray-drying method and evaluated for aerodynamic properties and pulmonary drug absorption. To control the drug release, tripoly-phosphate in different concentrations 0.6, 0.9, 1.2, and 1.5 was employed to get a sustained drug release profile. The microparticles were evaluated for drug loading, % entrapment efficiency, tapped density, morphological characteristics, and in vitro drug release studies. Aerosol properties were determined using the Andersen cascade impactor. Porous microparticles with particle sizes (d0.5) less than 10 μm were obtained. The entrapment of rifampicin in microparticles was up to 72%. In vitro drug release suggested that the crosslinked microparticles showed sustained release for more than 12 hrs. The drug release rate was found to be decreased as the TPP concentration was increased. The microparticles showed a fine particle fraction in the range of 55–63% with mass median aerodynamic diameter (MMAD) values below 3 μm. The in vivo pulmonary absorption of the chitosan microparticles suggested a sustained drug release profile up to 72 hrs with an elimination rate of 0.010 per hr. The studies revealed that the spray-dried porous microparticles have suitable properties to be used as respirable powder in rifampicin delivery to the lungs. PMID:25853075

  5. Examination of fungi in domestic interiors by using factor analysis: Correlations and associations with home factors. [Cladosporium, Alternaria, Epicoccum, Aureobasidium, Aspergillus; Penicillium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Su, H.J.; Rotnitzky, A.; Spengler, J.D.

    1992-01-01

    Factor analysis was utilized to investigate correlations among airborne microorganisms collected with Andersen samplers from homes in Topeka, Kans., during the winter of 1987 to 1988. The factors derived were used to relate microbial concentrations with categorical, questionnaire-derived descriptions of housing conditions. This approach successfully identified groups of common aboveground decay fungi including Cladosporium, Alternaria, Epicoccum, and Aureobasidium spp. The common soil fungi Aspergillus and Penicillium spp. were also separated as a group. These previously known ecological groupings were confirmed with air sampling data by a quantitative evaluation technique. The above ground decay fungi sampled indoors in winter were presentmore » at relatively high concentrations in homes with gas stoves for cooking, suggesting a possible association between these fungi and increased humidity from the combustion process. Elevated concentrations of the soil fungi were significantly associated with the dirt floor, crawl-space type of basement. Elevated concentrations of water-requiring fungi, such as Fusarium spp., were shown to be associated with water collection in domestic interiors. Also, elevated mean concentrations for the group of fungi including Cladosporium, Epicoccum, Aureobasidium, and yeast spp. were found to be associated with symptoms reported on a health questionnaire. This finding was consistent with the authors previous study of associations between respiratory health and airborne microorganisms by univariate logistic regression analysis.« less

  6. Heat-Stable Dry Powder Oxytocin Formulations for Delivery by Oral Inhalation.

    PubMed

    Fabio, Karine; Curley, Kieran; Guarneri, Joseph; Adamo, Benoit; Laurenzi, Brendan; Grant, Marshall; Offord, Robin; Kraft, Kelly; Leone-Bay, Andrea

    2015-12-01

    In this work, heat stable dry powders of oxytocin (OT) suitable for delivery by oral inhalation were prepared. The OT dry powders were prepared by spray drying using excipients chosen to promote OT stability including trehalose, isoleucine, polyvinylpyrrolidone, citrate (sodium citrate and citric acid), and zinc salts (zinc chloride and zinc citrate). Characterization by laser diffraction indicated that the OT dry powders had a median particle size of 2 μm, making them suitable for delivery by inhalation. Aerodynamic performance upon discharge from proprietary dry powder inhalers was evaluated by Andersen cascade impaction (ACI) and in an anatomically correct airway (ACA) model, and confirmed that the powders had excellent aerodynamic performance, with respirable fractions up to 77% (ACI, 30 L/min). Physicochemical characterization demonstrated that the powders were amorphous (X-ray diffraction) with high glass transition temperature (modulated differential scanning calorimetry, MDSC), suggesting the potential for stabilization of the OT in a glassy amorphous matrix. OT assay and impurity profile were conducted by reverse phase HPLC and liquid chromatography-mass spectrometry (LC-MS) after storage up to 32 weeks at 40°C/75%RH. Analysis demonstrated that OT dry powders containing a mixture of citrate and zinc salts retained more than 90% of initial assay after 32 weeks storage and showed significant reduction in dimers and trisulfide formation (up to threefold reduction compared to control).

  7. Male Undergraduates' HPV Vaccination Behavior: Implications for Achieving HPV-Associated Cancer Equity.

    PubMed

    Lee, Hee Yun; Lust, Katherine; Vang, Suzanne; Desai, Jay

    2018-06-01

    Despite the availability of the human papillomavirus (HPV) vaccine for males, uptake of the vaccine has been low, particularly among young adult males. This study aimed to investigate the levels of HPV vaccination and predictors of HPV vaccine completion in college men ages 18-26. We analyzed data from the 2015 College Student Health Survey, which was administered at 17 post-secondary institutions in Midwest areas. We included only responses from male participants who were ages 18-26 years old, resulting in a sample size of 2516. We used Andersen's Behavioral Model of Health Services Utilization to guide our study design. Multivariate logistic regression was used to examine predictors of HPV vaccine receipt. College-aged males in our sample had a HPV vaccine completion rate of 50.0%. Male students who were younger, had at least one parent who held a graduate degree, had initiated sex, and were enrolled at a private 4-year institution were more likely to have been vaccinated. These findings suggest that HPV vaccination in college-aged men are low. Efforts are needed to increase HPV vaccination in male students who are older, from lower socioeconomic statuses, have not initiated sex, and enrolled at public institutions. Findings also indicate important gender disparities in vaccine uptake that must be addressed in order to achieve optimal vaccine uptake in college-aged males.

  8. Gentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats

    PubMed Central

    Dagil, Robert; O'Shea, Charlotte; Nykjær, Anders; Bonvin, Alexandre M. J. J.; Kragelund, Birthe B.

    2013-01-01

    Gentamicin is an aminoglycoside widely used in treatments of, in particular, enterococcal, mycobacterial, and severe Gram-negative bacterial infections. Large doses of gentamicin cause nephrotoxicity and ototoxicity, entering the cell via the receptor megalin. Until now, no structural information has been available to describe the interaction with gentamicin in atomic detail, and neither have any three-dimensional structures of domains from the human megalin receptor been solved. To address this gap in our knowledge, we have solved the NMR structure of the 10th complement type repeat of human megalin and investigated its interaction with gentamicin. Using NMR titration data in HADDOCK, we have generated a three-dimensional model describing the complex between megalin and gentamicin. Gentamicin binds to megalin with low affinity and exploits the common ligand binding motif previously described (Jensen, G. A., Andersen, O. M., Bonvin, A. M., Bjerrum-Bohr, I., Etzerodt, M., Thogersen, H. C., O'Shea, C., Poulsen, F. M., and Kragelund, B. B. (2006) J. Mol. Biol. 362, 700–716) utilizing the indole side chain of Trp-1126 and the negatively charged residues Asp-1129, Asp-1131, and Asp-1133. Binding to megalin is highly similar to gentamicin binding to calreticulin. We discuss the impact of this novel insight for the future structure-based design of gentamicin antagonists. PMID:23275343

  9. Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens

    PubMed Central

    Meliopoulos, Victoria A.; Andersen, Lauren E.; Birrer, Katherine F.; Simpson, Kaylene J.; Lowenthal, John W.; Bean, Andrew G. D.; Stambas, John; Stewart, Cameron R.; Tompkins, S. Mark; van Beusechem, Victor W.; Fraser, Iain; Mhlanga, Musa; Barichievy, Samantha; Smith, Queta; Leake, Devin; Karpilow, Jon; Buck, Amy; Jona, Ghil; Tripp, Ralph A.

    2012-01-01

    Influenza virus encodes only 11 viral proteins but replicates in a broad range of avian and mammalian species by exploiting host cell functions. Genome-wide RNA interference (RNAi) has proven to be a powerful tool for identifying the host molecules that participate in each step of virus replication. Meta-analysis of findings from genome-wide RNAi screens has shown influenza virus to be dependent on functional nodes in host cell pathways, requiring a wide variety of molecules and cellular proteins for replication. Because rapid evolution of the influenza A viruses persistently complicates the effectiveness of vaccines and therapeutics, a further understanding of the complex host cell pathways coopted by influenza virus for replication may provide new targets and strategies for antiviral therapy. RNAi genome screening technologies together with bioinformatics can provide the ability to rapidly identify specific host factors involved in resistance and susceptibility to influenza virus, allowing for novel disease intervention strategies.—Meliopoulos, V. A., Andersen, L. E., Birrer, K. F., Simpson, K. J., Lowenthal, J. W., Bean, A. G. D., Stambas, J., Stewart, C. R., Tompkins, S. M., van Beusechem, V. W., Fraser, I., Mhlanga, M., Barichievy, S., Smith, Q., Leake, D., Karpilow, J., Buck, A., Jona, G., Tripp, R. A. Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens. PMID:22247330

  10. Changes in airborne fungi from the outdoors to indoor air; large HVAC systems in nonproblem buildings in two different climates.

    PubMed

    Kemp, P C; Neumeister-Kemp, H G; Esposito, B; Lysek, G; Murray, F

    2003-01-01

    Little is known about the changes in occurrence and distribution of airborne fungi as they are transported in the airstream from the outdoor air through the heating, ventilation, and air conditioning (HVAC) system to the indoor air. To better understand this, airborne fungi were analyzed in the HVAC systems of two large office buildings in different climate zones. Fungal samples were taken in each of the walk-in chambers of the HVAC systems using a six-stage Andersen Sampler with malt extract agar. Results showed that fungal species changed with different locations in the HVAC systems. The outdoor air intake produced the greatest filtration effect for both the counts and species of outdoor air fungi. The colony forming unit (CFU) counts and species diversity was further reduced in the air directly after the filters. The cooling coils also had a substantial filtration effect. However, in room air the CFU counts were double and the mixture of fungal species was different from the air leaving the HVAC system at the supply air outlet in most locations. Diffusion of outdoor air fungi to the indoors did not explain the changes in the mixture of airborne fungi from the outdoor air to the indoor air, and some of the fungi present in the indoor air did not appear to be transported indoors by the HVAC systems.

  11. Dissolution of fine particle fraction from truncated Anderson cascade impactor with an enhancer cell.

    PubMed

    Tay, Justin Yong Soon; Liew, Celine Valeria; Heng, Paul Wan Sia

    2018-04-22

    Dissolution testing for inhalers were previously conducted either on unfractionated drug-carrier powders or drug of specific aerodynamic particle size. In this study, the collection of the full fine particle fraction (FPF) was attempted on a single stage. Capsules containing 30 mg of 2% salbutamol sulfate (SS) was tested to have a FPF of 9 ± 1% using the full set of Andersen cascade impactor (ACI) and a modified Rotahaler® capable of achieving 4.0 kPa pressure drop at 60 L/min air flow rate. A truncated ACI comprising the USP throat, pre-separator, stage 0, stage 4, stage F, polytetrafluoroethylene funnel (TF) and small collection plate (sCP) was found to be capable of achieving a FPF of 9% collected on TF and sCP. An adhesive tape was used to collect the FPF from the TF and sCP and held in place by an enhancer cell in a 200 mL round bottom vessel containing 50 mL Gamble's solution with 0.2 v/v, % Tween 80. Dissolution testing of SS and Seretide® showed burst release of SS and salmeterol while sustained release of fluticasone. This study demonstrated a reproducible method which may be used for evaluation of the full FPF of orally inhaled products. Copyright © 2018 Elsevier B.V. All rights reserved.

  12. Single and double acceptor-levels of a carbon-hydrogen defect in n-type silicon

    NASA Astrophysics Data System (ADS)

    Stübner, R.; Scheffler, L.; Kolkovsky, Vl.; Weber, J.

    2016-05-01

    In the present study, we discuss the origin of two dominant deep levels (E42 and E262) observed in n-type Si, which is subjected to hydrogenation by wet chemical etching or a dc H-plasma treatment. Their activation enthalpies determined from Laplace deep level transient spectroscopy measurements are EC-0.06 eV (E42) and EC-0.51 eV (E262). The similar annealing behavior and identical depth profiles of E42 and E262 correlate them with two different charge states of the same defect. E262 is attributed to a single acceptor state due to the absence of the Poole-Frenkel effect and the lack of a capture barrier for electrons. The emission rate of E42 shows a characteristic enhancement with the electric field, which is consistent with the assignment to a double acceptor state. In samples with different carbon and hydrogen content, the depth profiles of E262 can be explained by a defect with one H-atom and one C-atom. From a comparison with earlier calculations [Andersen et al., Phys. Rev. B 66, 235205 (2002)], we attribute E42 to the double acceptor and E262 to the single acceptor state of the CH1AB configuration, where one H atom is directly bound to carbon in the anti-bonding position.

  13. Predictors of healthcare utilization among older Mexican Americans.

    PubMed

    Al Snih, Soham; Markides, Kyriakos S; Ray, Laura A; Freeman, Jean L; Ostir, Glenn V; Goodwin, James S

    2006-01-01

    To examine the effects of predisposing, enabling, and need factors on physician and hospital use among older Mexican Americans. A two-year prospective cohort study. Five Southwestern states: Texas, New Mexico, Colorado, Arizona, and California. A population-based sample of 1987 non-institutionalized Mexican American men and women age > or =65 years. Physician and hospital utilization. Predictor variables included predisposing, enabling, and need factors. Ordinary least square and logistic regression analysis were used to model the effects of predictor factors specified in the Andersen model of health service use on physician and hospital use. After two years of follow-up, predisposing and enabling factors accounted for <5% of the variance in physician and hospital use. Need factors explained 21% of the variance in physician use and 7% of the variance in hospital use. Older age; being female; insurance coverage; having arthritis, diabetes, heart attack, hypertension, stroke, or cancer; and number of medications were factors associated with higher physician utilization. Subjects with arthritis, diabetes, hip fracture, high depressive symptoms, activities of daily living (ADL) disability, or high number of medications increased the odds of having any hospitalization. Subjects with diabetes, heart attack, hip fracture, ADL disabled, and high number of medications had a greater number of hospital nights than their counterparts. Older age, female sex, insurance coverage, and prevalent medical conditions are determinants of healthcare use among older Mexican Americans.

  14. Retention strategies and factors associated with missed visits among low income women at increased risk of HIV acquisition in the US (HPTN 064).

    PubMed

    Haley, Danielle F; Lucas, Jonathan; Golin, Carol E; Wang, Jing; Hughes, James P; Emel, Lynda; El-Sadr, Wafaa; Frew, Paula M; Justman, Jessica; Adimora, Adaora A; Watson, Christopher Chauncey; Mannheimer, Sharon; Rompalo, Anne; Soto-Torres, Lydia; Tims-Cook, Zandraetta; Carter, Yvonne; Hodder, Sally L

    2014-04-01

    Women at high-risk for HIV acquisition often face challenges that hinder their retention in HIV prevention trials. These same challenges may contribute to missed clinical care visits among HIV-infected women. This article, informed by the Gelberg-Andersen Behavioral Model for Vulnerable Populations, identifies factors associated with missed study visits and describes the multifaceted retention strategies used by study sites. HPTN 064 was a multisite, longitudinal HIV seroincidence study in 10 US communities. Eligible women were aged 18-44 years, resided in a census tract/zipcode with high poverty and HIV prevalence, and self-reported ≥1 personal or sex partner behavior related to HIV acquisition. Multivariate analyses of predisposing (e.g., substance use) and enabling (e.g., unmet health care needs) characteristics, and study attributes (i.e., recruitment venue, time of enrollment) identified factors associated with missed study visits. Retention strategies included: community engagement; interpersonal relationship building; reduction of external barriers; staff capacity building; and external tracing. Visit completion was 93% and 94% at 6 and 12 months. Unstable housing and later date of enrollment were associated with increased likelihood of missed study visits. Black race, recruitment from an outdoor venue, and financial responsibility for children were associated with greater likelihood of attendance. Multifaceted retention strategies may reduce missed study visits. Knowledge of factors associated with missed visits may help to focus efforts.

  15. Intercomparison between Individual Particles Scavenged as CCN and Those Collected at Ground-based Site on West Coast of Japan During Asian Dust Storm

    NASA Astrophysics Data System (ADS)

    Ma, C. J.; Tohno, S.; Kasahara, M.; Hayakawa, S.

    2002-12-01

    Asian dust storm particles can affect precipitation composition because they are either incorporated into cloud via condensation of water vapour (nucleation) or due to the uptake of particles by existing droplets. And subsequently they affect aquatic and terrestrial ecosystems. In order to study the intercorrelation between the chemical natures of both the particles collected at ground-based site and those scavenged as CCN, the intensive field measurement was carried out on west coast of Japan (Yasaka, Tango Peninsula, 35.62°N; 135.07°E) during dense Asian dust storm event on March 22, 2002. Due to the size dependence of the chemical composition of aerosol particle, size-segregated aerosol particles were collect using Low pressure Andersen impactor sampler. Also, to collect cloud droplets individually, a particular method for the cloud droplet replication was newly applied using collodion (nitrocellulose) film. Sampling of cloud droplets was performed at summit of a mountain (680 m) in Yasaka. To analyze the ambient individual aerosol particles and individual retained particles in cloud droplet, X-ray fluorescence (XRF) analytical method set at SPring-8 on BL39XU was applied. Analytical result enables us not only to compare the characteristics of individual particles scavenged as CCN and those collected at ground-based site, but also to estimate the influence of long-range transport.

  16. Assessment of workers' exposure to microorganisms when using biological degreasing stations.

    PubMed

    Villeneuve, Carol-Anne; Marchand, Geneviève; Gardette, Marie; Lavoie, Jacques; Neesham-Grenon, Eve; Bégin, Denis; Debia, Maximilien

    2018-06-01

    Biological degreasing stations (BDSs) are used by mechanics. These BDSs use a water-based solution with a microbial degradation process. Occupational exposure during the use of BDSs has not been reported and few studies have identified the bacteria present. The objectives were to measure the concentration of microorganisms during BDSs' use and monitor the bacterial community in the liquid over time. Five mechanical workshops were studied. Six 30-min samples were taken at each workshop over one year. Bioaerosols in the ambient air samples were collected with Andersen impactors near the BDS Bioaerosols in the workers' breathing zone (WBZ) were collected on filters. Fresh bio-degreasing fluids were collected from unopened containers, and used bio-degreasing fluids were collected in the BDS. The results show that the use of BDSs does not seem to increase bioaerosols concentrations in the WBZ (concentrations lower than 480 CFU/m 3 ) and that the bacterial communities (mainly yeasts, Bacillus subtilis and Pseudomonas aeruginosa) in the bio-degreasing fluids change through time and differ from the original community (B. subtilis). This study established that workers using BDSs were exposed to low levels of bioaerosols. No respiratory protection is recommended based on bioaerosols concentrations, but gloves and strict personal hygiene practices are essential. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Help-seeking behaviors for serious psychological distress among individuals with diabetes mellitus: The California Health Interview Survey, 2011-2012.

    PubMed

    Shin, Jinah K; Poltavskiy, Eduard; Kim, Tae Nyun; Hasan, Abdullah; Bang, Heejung

    2017-02-01

    To investigate patterns of and factors associated with help-seeking behaviors among individuals with diabetes mellitus (DM) and/or serious psychological distress (SPD). The analysis was conducted with the California Health Interview Survey (CHIS) 2011-2012 of 40,803 adults. Logistic regression was used to examine the associations between the multiple facilitating/preventing factors and outcome, guided by the Andersen's Health Care Utilization Model. The prevalence of DM and SPD were 10.9% and 3.4%, respectively, among participants in the survey. The participants with DM were more likely to experience SPD than those without DM (OR 1.46, 95% CI=1.11-1.91, p=0.006). Participants with combined DM and SPD, the most underserved, were less likely to perceive the need for mental health services and less likely to seek help, compared to those with only SPD. Need factors (SPD status and perceived need) were significantly associated with help-seeking behaviors for mental health, along with predisposing factors (age, gender, obesity, race, and employment), and enabling factors (insurance, English proficiency). Perceptions about need for seeking help seem to play an important role in receiving mental health services in addition to other predisposing or enabling factors. Identification of these factors may improve clinical outcomes related to DM and SPD. Copyright © 2016 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

  18. Extremity War Injuries X: Return to Health and Function.

    PubMed

    Davila, Col Jeffrey N; Swiontkowski, Marc F; Andersen, Col Ret Romney C

    2016-09-01

    The symposium Extremity War Injuries X: Return to Health and Function, presented by the American Academy of Orthopaedic Surgeons, the Orthopaedic Trauma Association, the Society of Military Orthopaedic Surgeons, and the Orthopaedic Research Society, was held in Washington, DC, on January 27 and 28, 2015. Course chairs Marc F. Swiontkowski, MD, and COL Jeffrey N. Davila, MD, presided over 2 days of general session lectures focusing on war/trauma-related musculoskeletal injuries resulting in service member disability, followed by small group discussions, with a goal of identifying knowledge gaps in the treatment of these injuries. Recognized civilian and military clinicians and researchers summarized the current state of knowledge in their topic areas and led these discussion groups with meeting participants. Musculoskeletal conditions discussed included posttraumatic osteoarthritis of the knee, foot, and ankle and their relationship to chronic ligament injuries; back disability; peripheral nerve injury; hand transplantation updates; the role of biologics; and prosthetic acceptance and function. A scientific program highlighting research presented by 12 investigators was led by COL (Ret) Romney C. Andersen, MD. Keynote speaker LT GEN Douglas J. Robb, MD, discussed the future of military research funding and the anticipated consolidation of medical care among the three military branches. Additional presentations referencing the impact of military medical care and the government's continued commitment to funding medical research occurred throughout the symposium and were given by five congressional representatives.

  19. Marital Status and Persons With Dementia in Assisted Living.

    PubMed

    Fields, Noelle L; Richardson, Virginia E; Schuman, Donna

    2017-03-01

    Despite the prevalence of dementia among residents in assisted living (AL), few researchers have focused on the length of stay (LOS) in AL among this population. Little is known about the factors that may contribute to LOS in these settings, particularly for residents with dementia. In the current study, a sub-set of AL residents with dementia (n = 112) was utilized to examine whether marital status was associated with LOS in AL as this has received sparse attention in previous research despite studies suggesting that marital status influences LOS in other health-care and long-term care settings. The Andersen-Newman behavioral model was used as a conceptual framework for the basis of this study of LOS, marital status, and dementia in AL. We hypothesized that persons with dementia who were married would have longer LOS than unmarried persons with dementia in AL. Cox regression was used to examine the association between marital status and LOS in AL of residents with dementia and whether activities of daily living were related to discharge from AL settings among married and unmarried residents with dementia. Main effects for marital status and the interaction between marital status and mobility with LOS were examined. Study findings provide information related to the psychosocial needs of AL residents with dementia and offer implications for assessing the on-going needs of vulnerable AL residents.

  20. Driven fragmentation of granular gases.

    PubMed

    Cruz Hidalgo, Raúl; Pagonabarraga, Ignacio

    2008-06-01

    The dynamics of homogeneously heated granular gases which fragment due to particle collisions is analyzed. We introduce a kinetic model which accounts for correlations induced at the grain collisions and analyze both the kinetics and relevant distribution functions these systems develop. The work combines analytical and numerical studies based on direct simulation Monte Carlo calculations. A broad family of fragmentation probabilities is considered, and its implications for the system kinetics are discussed. We show that generically these driven materials evolve asymptotically into a dynamical scaling regime. If the fragmentation probability tends to a constant, the grain number diverges at a finite time, leading to a shattering singularity. If the fragmentation probability vanishes, then the number of grains grows monotonously as a power law. We consider different homogeneous thermostats and show that the kinetics of these systems depends weakly on both the grain inelasticity and driving. We observe that fragmentation plays a relevant role in the shape of the velocity distribution of the particles. When the fragmentation is driven by local stochastic events, the long velocity tail is essentially exponential independently of the heating frequency and the breaking rule. However, for a Lowe-Andersen thermostat, numerical evidence strongly supports the conjecture that the scaled velocity distribution follows a generalized exponential behavior f(c) approximately exp(-cn) , with n approximately 1.2 , regarding less the fragmentation mechanisms.

  1. The Health and Social Isolation of American Veterans Denied Veterans Affairs Disability Compensation.

    PubMed

    Fried, Dennis Adrian; Passannante, Marian; Helmer, Drew; Holland, Bart K; Halperin, William E

    2017-02-01

    Authors comparatively analyzed health and social isolation between U.S. military veterans denied Veterans Affairs (VA) disability compensation and veterans awarded VA disability compensation. The 2001 National Survey of Veterans was used to create a sample of 4,522 veterans denied or awarded VA disability compensation. Using the Andersen health services utilization model as a conceptual framework, multivariate logistic regression was applied to assess relationships between VA disability compensation award status, three separate domains of health, and correlates of social isolation. Results indicate that denied applicants were more likely than those awarded to have poor overall health (odds ratio [OR] = 1.45, 95% confidence interval [CI]: 1.23, 1.70), and limitations in activities of daily living (OR = 1.12, 95% CI: 1.03, 1.21). Denied applicants' physical functioning (40.3) and mental functioning (41.2) composite summary scores were not clinically different from those of awarded applicants (39.0 and 40.1, respectively), indicating that both were comparably impaired. Veterans denied VA disability compensation had poor health and functional impairments. They also experienced poverty and isolation, suggesting that they may be in need of additional supportive services. Connecting veterans to community resources could be a vital service to provide to all veterans applying for disability compensation. © 2016 National Association of Social Workers.

  2. Particle size and composition distribution analysis of automotive brake abrasion dusts for the evaluation of antimony sources of airborne particulate matter

    NASA Astrophysics Data System (ADS)

    Iijima, Akihiro; Sato, Keiichi; Yano, Kiyoko; Tago, Hiroshi; Kato, Masahiko; Kimura, Hirokazu; Furuta, Naoki

    Abrasion dusts from three types of commercially available non-steel brake pads were generated by a brake dynamometer at disk temperatures of 200, 300 and 400 °C. The number concentration of the abrasion dusts and their aerodynamic diameters ( Dp) were measured by using an aerodynamic particle sizer (APS) spectrometer with high temporal and size resolution. Simultaneously, the abrasion dusts were also collected based on their size by using an Andersen low-volume sampler, and the concentrations of metallic elements (K, Ti, Fe, Cu, Zn, Sb and Ba) in the size-classified dusts were measured by ICP-AES and ICP-MS. The number distributions of the brake abrasion dusts had a peak at Dp values of 1 and 2 μm; this peak shifted to the coarse side with an increase in the disk temperature. The mass distributions calculated from the number distributions have peaks between Dp values of 3 and 6 μm. The shapes of the elemental mass distributions (Ti, Fe, Cu, Zn, Sb and Ba) in size-classified dusts were very similar to the total mass distributions of the brake abrasion dusts. These experimental results indicated that the properties of brake abrasion dusts were consistent with the characteristics of Sb-enriched fine airborne particulate matter. Based on these findings and statistical data, the estimation of Sb emission as airborne particulate matter from friction brakes was also discussed.

  3. Predicting health care utilization in marginalized populations: Black, female, street-based sex workers.

    PubMed

    Varga, Leah M; Surratt, Hilary L

    2014-01-01

    Patterns of social and structural factors experienced by vulnerable populations may negatively affect willingness and ability to seek out health care services, and ultimately, their health. The outcome variable was utilization of health care services in the previous 12 months. Using Andersen's Behavioral Model for Vulnerable Populations, we examined self-reported data on utilization of health care services among a sample of 546 Black, street-based, female sex workers in Miami, Florida. To evaluate the impact of each domain of the model on predicting health care utilization, domains were included in the logistic regression analysis by blocks using the traditional variables first and then adding the vulnerable domain variables. The most consistent variables predicting health care utilization were having a regular source of care and self-rated health. The model that included only enabling variables was the most efficient model in predicting health care utilization. Any type of resource, link, or connection to or with an institution, or any consistent point of care, contributes significantly to health care utilization behaviors. A consistent and reliable source for health care may increase health care utilization and subsequently decrease health disparities among vulnerable and marginalized populations, as well as contribute to public health efforts that encourage preventive health. Copyright © 2014 Jacobs Institute of Women's Health. Published by Elsevier Inc. All rights reserved.

  4. Ethnic differences in the diagnosis of schizophrenia and mood disorders during admission to an academic safety-net psychiatric hospital.

    PubMed

    Hamilton, Jane E; Heads, Angela M; Meyer, Thomas D; Desai, Pratikkumar V; Okusaga, Olaoluwa O; Cho, Raymond Y

    2018-05-30

    U.S. Hispanics, now the single largest minority group in the country, face unique mental health disparities. The current study utilizes Andersen's Behavioral Model of Health Service Use to examine ethnic disparities in receiving a schizophrenia or mood disorder diagnosis at psychiatric hospital admission. Our retrospective cohort study examined electronic health record data at an academic safety-net psychiatric hospital for adult patients (n = 5571) admitted between 2010 and 2013. Logistic regression with block-wise entry of predisposing, enabling and need variables was used to examine ethnic disparities in receiving a schizophrenia diagnosis at admission. The block of need factors was the strongest predictor of receiving a schizophrenia diagnosis compared to predisposing and enabling factors. Compared to non-Hispanic whites, Hispanics and African Americans had a greater likelihood of receiving a schizophrenia diagnosis at admission. Additionally, patients diagnosed with schizophrenia had elevated positive and negative symptoms and were more likely to be male, single/unmarried, homeless, high inpatient service utilizers, involuntarily hospitalized, and to exhibit functional impairment at psychiatric hospital admission. To address elevated positive and negative symptoms of schizophrenia, functional impairment, social withdrawal, and high inpatient service utilization, promising psychosocial interventions should be adapted for racial and ethnic minority populations and utilized as an adjuvant to antipsychotic medication. Copyright © 2018. Published by Elsevier B.V.

  5. Self-associated submicron IgG1 particles for pulmonary delivery: effects of non-ionic surfactants on size, shape, stability, and aerosol performance.

    PubMed

    Srinivasan, Asha R; Shoyele, Sunday A

    2013-03-01

    The ability to produce submicron particles of monoclonal antibodies of different sizes and shapes would enhance their application to pulmonary delivery. Although non-ionic surfactants are widely used as stabilizers in protein formulations, we hypothesized that non-ionic surfactants will affect the shape and size of submicron IgG particles manufactured through precipitation. Submicron particles of IgG1 were produced by a precipitation process which explores the fact that proteins have minimum solubility but maximum precipitation at the isoelectric point. Non-ionic surfactants were used for size and shape control, and as stabilizing agents. Aerosol performance of the antibody nanoparticles was assessed using Andersen Cascade Impactor. Spinhaler® and Handihaler® were used as model DPI devices. SEM micrographs revealed that the shape of the submicron particles was altered by varying the type of surfactant added to the precipitating medium. Particle size as measured by dynamic light scattering was also varied based on the type and concentration of the surfactant. The surfactants were able to stabilize the IgG during the precipitation process. Polyhedral, sponge-like, and spherical nanoparticles demonstrated improved aerosolization properties compared to irregularly shaped (>20 μm) unprocessed particles. Stable antibody submicron particles of different shapes and sizes were prepared. Careful control of the shape of such particles is critical to ensuring optimized lung delivery by dry powder inhalation.

  6. The effects of some tumor markers on human erythrocyte (HCA-I and HCA-II), bovine erythrocyte (BCA) and bovine lung (CA-IV) carbonic anhydrase enzyme activities in vitro.

    PubMed

    Demir, N; Nadaroglu, H; Gungor, A A; Demir, Y

    2015-01-01

    The influence of prostatic acid phosphatase (PAP) and human chorionic gonadotropin (HCG), tumor markers have been investigated on human erythrocyte carbonic anhydrase (HCA-I and HCA-II) and bovine erythrocyte (BCA) and bovine lung carbonic anhydrase (CA-IV) in vitro. Tumor markers are substances that can often be detected in higher-than-normal amounts in the blood, urine, or body tissues of some patients with certain types of cancer. Tumor markers are produced either by the tumor itself or by the body in response to the presence of cancer or certain benign (noncancerous) conditions. In addition to their role in cancer diagnosis, some tumor marker levels are measured before treatment to help doctors plan appropriate therapy. All of the tumor markers were determined to have inhibition effect, on human CA-I, CA-II, bovine erythrocyte CA (BCA) and bovine lung CA-IV isoenzymes. The effect of each tumor marker on CA was investigated by Wilbur-Andersen method modified by Rickly et al Inhibition effects of two different tumor markers on human CA-I, CA-II, bovine erythrocyte CA (BCA) and bovine lung CA-IV isoenzymes were determined by using the CO2-Hydratase method by plotting activity % vs (tumor markers). I50 values of tumor markers exhibiting inhibition effects were found by means of these graphs (Tab.1, Fig. 2, Ref. 20).

  7. Retention Strategies and Factors Associated with Missed Visits Among Low Income Women at Increased Risk of HIV Acquisition in the US (HPTN 064)

    PubMed Central

    Lucas, Jonathan; Golin, Carol E.; Wang, Jing; Hughes, James P.; Emel, Lynda; El-Sadr, Wafaa; Frew, Paula M.; Justman, Jessica; Adimora, Adaora A.; Watson, Christopher Chauncey; Mannheimer, Sharon; Rompalo, Anne; Soto-Torres, Lydia; Tims-Cook, Zandraetta; Carter, Yvonne; Hodder, Sally L.

    2014-01-01

    Abstract Women at high-risk for HIV acquisition often face challenges that hinder their retention in HIV prevention trials. These same challenges may contribute to missed clinical care visits among HIV-infected women. This article, informed by the Gelberg-Andersen Behavioral Model for Vulnerable Populations, identifies factors associated with missed study visits and describes the multifaceted retention strategies used by study sites. HPTN 064 was a multisite, longitudinal HIV seroincidence study in 10 US communities. Eligible women were aged 18–44 years, resided in a census tract/zipcode with high poverty and HIV prevalence, and self-reported ≥1 personal or sex partner behavior related to HIV acquisition. Multivariate analyses of predisposing (e.g., substance use) and enabling (e.g., unmet health care needs) characteristics, and study attributes (i.e., recruitment venue, time of enrollment) identified factors associated with missed study visits. Retention strategies included: community engagement; interpersonal relationship building; reduction of external barriers; staff capacity building; and external tracing. Visit completion was 93% and 94% at 6 and 12 months. Unstable housing and later date of enrollment were associated with increased likelihood of missed study visits. Black race, recruitment from an outdoor venue, and financial responsibility for children were associated with greater likelihood of attendance. Multifaceted retention strategies may reduce missed study visits. Knowledge of factors associated with missed visits may help to focus efforts. PMID:24697160

  8. Variables Associated With Perceived Unmet Need for Mental Health Care in a Canadian Epidemiologic Catchment Area.

    PubMed

    Fleury, Marie-Josée; Grenier, Guy; Bamvita, Jean-Marie; Perreault, Michel; Caron, Jean

    2016-01-01

    This study identified variables associated with perceived partially met and unmet needs for information, medication, and counseling, as well as overall perceived unmet needs, related to mental health among 571 people in a Canadian epidemiologic catchment area. Needs were measured with the Perceived Need for Care Questionnaire and a comprehensive set of independent variables based on Andersen's behavioral model. Four models were constructed for the following dependent variables: perceived unmet needs for information, medication, and counseling (multinomial logistic regression) and overall perceived unmet needs (multiple logistic regression). The proportions reporting fully unmet need were as follows: counseling, 30%; information, 18%; and medication, 4%. Variables associated with unmet needs for information, medication, and counseling were quite distinct. Enabling factors (for example, neighborhood perception variables) were strongly associated with perceived unmet need for information. Need factors were more strongly associated with unmet need for medication, predisposing factors with unmet needs for information and medication, and health service use with unmet information and counseling needs. People whose overall needs went unmet tended to be younger, to have an addiction, and to have consulted fewer professionals. Mental health services should facilitate access to psychologists or other clinicians to better meet counseling and information needs. They should also take neighborhoods into account when assessing needs and provide more information about mental disorders and the treatments and services offered in disadvantaged areas. Finally, services should be further developed for younger people with addiction, who tend to be stigmatized and avoid using health services.

  9. A critical evaluation of perturbation theories by Monte Carlo simulation of the first four perturbation terms in a Helmholtz energy expansion for the Lennard-Jones fluid

    NASA Astrophysics Data System (ADS)

    van Westen, Thijs; Gross, Joachim

    2017-07-01

    The Helmholtz energy of a fluid interacting by a Lennard-Jones pair potential is expanded in a perturbation series. Both the methods of Barker-Henderson (BH) and of Weeks-Chandler-Andersen (WCA) are evaluated for the division of the intermolecular potential into reference and perturbation parts. The first four perturbation terms are evaluated for various densities and temperatures (in the ranges ρ*=0 -1.5 and T*=0.5 -12 ) using Monte Carlo simulations in the canonical ensemble. The simulation results are used to test several approximate theoretical methods for describing perturbation terms or for developing an approximate infinite order perturbation series. Additionally, the simulations serve as a basis for developing fully analytical third order BH and WCA perturbation theories. The development of analytical theories allows (1) a careful comparison between the BH and WCA formalisms, and (2) a systematic examination of the effect of higher-order perturbation terms on calculated thermodynamic properties of fluids. Properties included in the comparison are supercritical thermodynamic properties (pressure, internal energy, and chemical potential), vapor-liquid phase equilibria, second virial coefficients, and heat capacities. For all properties studied, we find a systematically improved description upon using a higher-order perturbation theory. A result of particular relevance is that a third order perturbation theory is capable of providing a quantitative description of second virial coefficients to temperatures as low as the triple-point of the Lennard-Jones fluid. We find no reason to prefer the WCA formalism over the BH formalism.

  10. Discovering long-term potentiation (LTP) - recollections and reflections on what came after.

    PubMed

    Lømo, T

    2018-02-01

    Chance events led me to a lifelong career in scientific research. They paved the way for being the first to see long-term potentiation of synaptic efficiency (LTP) in Per Andersen's laboratory in Oslo in 1966. Here I describe my way to this discovery and the experiments with Tim Bliss in 1968-1969 that led to Bliss and Lømo, 1973. Surprisingly, we later failed to reproduce these results. I discuss possible reasons for this failure, which made us both leave LTP research, in my case for good, in Tim's case for several years. After 30 years of work in a different field, I renewed my interest in the hippocampus and LTP in the early 2000s and published, for the first time, results that I had obtained 40 years earlier. Here I present my take on how interest in and research on LTP evolved after the early years. This includes a discussion of the functions of hippocampus as seen in those early days, the case of patient H.M., Donald Hebb's place in the story, the search for 'memory molecules' such as PKMζ, and the primary site for LTP expression (pre- and/or post-synaptic?). Throughout, I reflect on my life in science, how science is done and what drives it. The reflections are quite personal and I admit to mixed feelings about broadcasting them. © 2017 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

  11. Which need characteristics influence healthcare service utilization in home care arrangements in Germany?

    PubMed

    Dorin, Lena; Turner, Suzi C; Beckmann, Lea; große Schlarmann, Jörg; Faatz, Andreas; Metzing, Sabine; Büscher, Andreas

    2014-05-22

    We see a growing number of older adults receiving long-term care in industrialized countries. The Healthcare Utilization Model by Andersen suggests that individual need characteristics influence utilization. The purpose of this study is to analyze correlations between need characteristics and service utilization in home care arrangements. 1,152 respondents answered the questionnaire regarding their integration of services in their current and future care arrangements. Care recipients with high long-term care needs answered the questionnaire on their own, the family caregiver assisted the care recipient in answering the questions, or the family caregiver responded to the questionnaire on behalf of the care recipient. They were asked to rank specific needs according to their situation. We used descriptive statistics and regression analysis. Respondents are widely informed about services. Nursing services and counseling are the most used services. Short-term care and guidance and training have a high potential for future use. Day care, self-help groups, and mobile services were the most frequently rejected services in our survey. Women use more services than men and with rising age utilization increases. Long waiting times and bad health of the primary caregiver increases the chance of integrating services into the home care arrangements. The primary family caregiver has a high impact on service utilization. This indicates that the whole family should be approached when offering services. Professionals should react upon the specific needs of care dependents and their families.

  12. Which need characteristics influence healthcare service utilization in home care arrangements in Germany?

    PubMed Central

    2014-01-01

    Background We see a growing number of older adults receiving long-term care in industrialized countries. The Healthcare Utilization Model by Andersen suggests that individual need characteristics influence utilization. The purpose of this study is to analyze correlations between need characteristics and service utilization in home care arrangements. Methods 1,152 respondents answered the questionnaire regarding their integration of services in their current and future care arrangements. Care recipients with high long-term care needs answered the questionnaire on their own, the family caregiver assisted the care recipient in answering the questions, or the family caregiver responded to the questionnaire on behalf of the care recipient. They were asked to rank specific needs according to their situation. We used descriptive statistics and regression analysis. Results Respondents are widely informed about services. Nursing services and counseling are the most used services. Short-term care and guidance and training have a high potential for future use. Day care, self-help groups, and mobile services were the most frequently rejected services in our survey. Women use more services than men and with rising age utilization increases. Long waiting times and bad health of the primary caregiver increases the chance of integrating services into the home care arrangements. Conclusion The primary family caregiver has a high impact on service utilization. This indicates that the whole family should be approached when offering services. Professionals should react upon the specific needs of care dependents and their families. PMID:24884598

  13. Method for hue plane preserving color correction.

    PubMed

    Mackiewicz, Michal; Andersen, Casper F; Finlayson, Graham

    2016-11-01

    Hue plane preserving color correction (HPPCC), introduced by Andersen and Hardeberg [Proceedings of the 13th Color and Imaging Conference (CIC) (2005), pp. 141-146], maps device-dependent color values (RGB) to colorimetric color values (XYZ) using a set of linear transforms, realized by white point preserving 3×3 matrices, where each transform is learned and applied in a subregion of color space, defined by two adjacent hue planes. The hue plane delimited subregions of camera RGB values are mapped to corresponding hue plane delimited subregions of estimated colorimetric XYZ values. Hue planes are geometrical half-planes, where each is defined by the neutral axis and a chromatic color in a linear color space. The key advantage of the HPPCC method is that, while offering an estimation accuracy of higher order methods, it maintains the linear colorimetric relations of colors in hue planes. As a significant result, it therefore also renders the colorimetric estimates invariant to exposure and shading of object reflection. In this paper, we present a new flexible and robust version of HPPCC using constrained least squares in the optimization, where the subregions can be chosen freely in number and position in order to optimize the results while constraining transform continuity at the subregion boundaries. The method is compared to a selection of other state-of-the-art characterization methods, and the results show that it outperforms the original HPPCC method.

  14. Associations of Adiposity and Aerobic Fitness with Executive Function and Math Performance in Danish Adolescents.

    PubMed

    Huang, Tao; Tarp, Jakob; Domazet, Sidsel Louise; Thorsen, Anne Kær; Froberg, Karsten; Andersen, Lars Bo; Bugge, Anna

    2015-10-01

    To examine the associations of adiposity and aerobic fitness with executive function and math performance in Danish adolescents. Cross-sectional analyses were conducted with data on 525 adolescents attending sixth and seventh grades from 14 schools in the 5 main regions of Denmark. A modified Eriksen flanker task was used to assess inhibitory control, a key aspect of executive function. Academic performance was assessed by a customized math test. Aerobic fitness was assessed by an intermittent shuttle-run test (Andersen test). Body mass index (BMI) was negatively associated with accuracy on incongruent trials during the flanker task (P = .005). A higher BMI was associated with a larger accuracy interference score (P = .01). Similarly, waist circumference (WC) was negatively associated with accuracy on incongruent trials (P = .008). A higher WC was associated with a larger reaction time (RT) interference score (P = .02) and accuracy interference score (P = .009). Higher aerobic fitness was associated with a faster RT on congruent trials (P = .009) and incongruent trials (P = .003). Higher aerobic fitness was associated with a smaller RT interference score (P = .04). Aerobic fitness was positively associated with math score (P < .001). BMI and WC were not associated with math score (P > .05). These results suggest that aerobic fitness is positively associated with both inhibitory control and math performance in adolescents. Adiposity is negatively associated with inhibitory control in adolescents. Adiposity is not associated with math performance. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Environmental assessment of an enhanced-oil-recovery steam generator equipped with a low-NOx burner. Volume 1. Technical results. Final report, January 1984-January 1985

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Castaldini, C.; Waterland, L.R.; Lips, H.I.

    1986-02-01

    The report discusses results from sampling flue gas from an enhanced-oil-recovery steam generator (EOR steamer) equipped with an MHI PM low-NOx burner. The tests included burner performance/emission mapping tests, comparative testing of an identical steamer equipped with a conventional burner, and comprehensive testing of the low-NOx-burner-equipped steamer. Comprehensive test measurements included continuous flue-gas monitoring; source assessment sampling system testing with subsequent laboratory analysis to give total flue-gas organics in two boiling point ranges and specific quantitation on the semivolatile organic priority pollutants; C1 to C6 hydrocarbon sampling; Methods 5/8 sampling for particulate and SO/sub 2/ and SO/sub 3/ emissions; andmore » emitted particle size distribution tests using Andersen impactors. Full-load NOx emissions of 110 ppm (3% O/sub 2/) could be maintained from the low-NOx burner at acceptable CO and smoke emissions, compared to about 300 ppm (3% O/sub 2/) from the conventional-burner-equipped steamer. At the low-NOx condition, CO, SO/sub 2/, and SO/sub 3/ emissions were 93, 594, and 3.1 ppm, respectively. Particulate emissions were 39 mg/dscm with a mean particle diameter of 3 to 4 micrometers. Total organic emissions were 11.1 mg/dscm, almost exclusively volatile (C1 to C6) organics. Three PAHs were detected at from 0.1 to 1.4 micrograms/dscm.« less

  16. Reconciling the understanding of 'hydrophobicity' with physics-based models of proteins.

    PubMed

    Harris, Robert C; Pettitt, B Montgomery

    2016-03-02

    The idea that a 'hydrophobic energy' drives protein folding, aggregation, and binding by favoring the sequestration of bulky residues from water into the protein interior is widespread. The solvation free energies (ΔGsolv) of small nonpolar solutes increase with surface area (A), and the free energies of creating macroscopic cavities in water increase linearly with A. These observations seem to imply that there is a hydrophobic component (ΔGhyd) of ΔGsolv that increases linearly with A, and this assumption is widely used in implicit solvent models. However, some explicit-solvent molecular dynamics studies appear to contradict these ideas. For example, one definition (ΔG(LJ)) of ΔGhyd is that it is the free energy of turning on the Lennard-Jones (LJ) interactions between the solute and solvent. However, ΔG(LJ) decreases with A for alanine and glycine peptides. Here we argue that these apparent contradictions can be reconciled by defining ΔGhyd to be a near hard core insertion energy (ΔGrep), as in the partitioning proposed by Weeks, Chandler, and Andersen. However, recent results have shown that ΔGrep is not a simple function of geometric properties of the molecule, such as A and the molecular volume, and that the free energy of turning on the attractive part of the LJ potential cannot be computed from first-order perturbation theory for proteins. The theories that have been developed from these assumptions to predict ΔGhyd are therefore inadequate for proteins.

  17. Decoding Target Distance and Saccade Amplitude from Population Activity in the Macaque Lateral Intraparietal Area (LIP)

    PubMed Central

    Bremmer, Frank; Kaminiarz, Andre; Klingenhoefer, Steffen; Churan, Jan

    2016-01-01

    Primates perform saccadic eye movements in order to bring the image of an interesting target onto the fovea. Compared to stationary targets, saccades toward moving targets are computationally more demanding since the oculomotor system must use speed and direction information about the target as well as knowledge about its own processing latency to program an adequate, predictive saccade vector. In monkeys, different brain regions have been implicated in the control of voluntary saccades, among them the lateral intraparietal area (LIP). Here we asked, if activity in area LIP reflects the distance between fovea and saccade target, or the amplitude of an upcoming saccade, or both. We recorded single unit activity in area LIP of two macaque monkeys. First, we determined for each neuron its preferred saccade direction. Then, monkeys performed visually guided saccades along the preferred direction toward either stationary or moving targets in pseudo-randomized order. LIP population activity allowed to decode both, the distance between fovea and saccade target as well as the size of an upcoming saccade. Previous work has shown comparable results for saccade direction (Graf and Andersen, 2014a,b). Hence, LIP population activity allows to predict any two-dimensional saccade vector. Functional equivalents of macaque area LIP have been identified in humans. Accordingly, our results provide further support for the concept of activity from area LIP as neural basis for the control of an oculomotor brain-machine interface. PMID:27630547

  18. Latino suicidal adolescent psychosocial service utilization: The role of mood fluctuations and inattention.

    PubMed

    Alonzo, Dana; Conway, Anne; Modrek, Anahid S

    2016-01-15

    Little is known about the specific factors related to whether or not Latino adolescents with suicide ideation (SI) will seek services. Utilizing Andersen's Behavior Model of Health Services Use (2008) the goal of this study is to identify the factors related to utilization of mental health services by Latino adolescents with SI to inform and improve suicide prevention efforts. Data from Wave 1 of the National Longitudinal Study of Adolescent Health was examined. Predispositional (gender, age), enabling/disabling (income, lack of insurance, difficulty obtaining medical care), and need (depressed mood, suicide attempt, perceived health, impulsivity, mood fluctuations, difficulties with attention, etc.) variables were examined via logistic regression as potential correlates of mental health service utilization. Twenty-eight percent of the Latino adolescents with suicidal ideation (SI) in our sample received mental health services. Need factors such as daily mood fluctuations within the past 12 months (OR=4.78) and frequent difficulty focusing attention within the past week (OR=4.96), but not impulsivity, were associated with an increased likelihood of receiving mental health services. No additional associations were observed. The current study is based on cross-sectional data. Therefore, statements about causality cannot be made. These findings suggest that emotion regulation (e.g., daily mood fluctuations) and neurocognitive factors (e.g., difficulty with focusing attention) may be important factors to consider in the clinical assessment of Latino adolescents with SI. Copyright © 2015. Published by Elsevier B.V.

  19. Effect of pH and leucine concentration on aerosolization properties of carrier-free formulations of levofloxacin.

    PubMed

    Barazesh, Ahmadreza; Gilani, Kambiz; Rouini, Mohammadreza; Barghi, Mohammad Ali

    2018-06-15

    The aim of this study was to evaluate the effect of leucine at different pH values preferred for inhalation on particle characteristics and aerosolization performance of spray dried carrier-free formulations of levofloxacin. A full factorial design was applied to optimize the formulation containing levofloxacin with or without leucine in different pH values and the optimum condition was determined. Particle size and morphology, crystallinity state, electrostatic charge and surface composition of the particles were determined. Aerodynamic properties of the powders were also assessed by an Andersen cascade impactor after aerosolization through an Aerolizer® at an air flow rate of 60 L/min. The pH of initial solution affected various physical properties of the drug containing particles and hence their in vitro deposition. The profound effect of pH was on water content, electrostatic charge and surface composition of the particles. The negative effect of water content on in vitro deposition of the drug was covered by preferred surface accumulation of leucine at pH 6. Optimum formulation which obtained by co-spray drying of the drug with 21.79% leucine at pH 5.98 presented a fine particle fraction equal to 54.38. In conclusion, changing pH of the initial solution influenced the effect of leucine on aerosolization of levofloxacine spray dried particles by modification of their physical properties. Copyright © 2018 Elsevier B.V. All rights reserved.

  20. The typical developmental trajectory of social and executive functions in late adolescence and early adulthood.

    PubMed

    Taylor, Sophie Jane; Barker, Lynne Ann; Heavey, Lisa; McHale, Sue

    2013-07-01

    Executive functions and social cognition develop through childhood into adolescence and early adulthood and are important for adaptive goal-oriented behavior (Apperly, Samson, & Humphreys, 2009; Blakemore & Choudhury, 2006). These functions are attributed to frontal networks known to undergo protracted maturation into early adulthood (Barker, Andrade, Morton, Romanowski, & Bowles, 2010; Lebel, Walker, Leemans, Phillips, & Beaulieu, 2008), although social cognition functions are also associated with widely distributed networks. Previously, nonlinear development has been reported around puberty on an emotion match-to-sample task (McGivern, Andersen, Byrd, Mutter, & Reilly, 2002) and for IQ in midadolescence (Ramsden et al., 2011). However, there are currently little data on the typical development of social and executive functions in late adolescence and early adulthood. In a cross-sectional design, 98 participants completed tests of social cognition and executive function, Wechsler Abbreviated Scale of Intelligence (Wechsler, 1999), Positive and Negative Affect Schedule (Watson, Clark, & Tellegen, 1988), Hospital Anxiety and Depression Scale (Zigmond & Snaith, 1983), and measures of pubertal development and demographics at ages 17, 18, and 19. Nonlinear age differences for letter fluency and concept formation executive functions were found, with a trough in functional ability in 18-year-olds compared with other groups. There were no age group differences on social cognition measures. Gender accounted for differences on 1 scale of concept formation, 1 dynamic social interaction scale, and 2 empathy scales. The clinical, developmental, and educational implications of these findings are discussed.

  1. An 88-year-old man with syncope and an alternating axis.

    PubMed

    Zhao, Yun-Tao; Huang, Yen Shu; Yi, Zhong

    2016-05-15

    An 88-year-old man, admitted to the emergency room (ER) after three episodes of syncope within 1 day, reported a precursory of syndrome of light-headedness with rapid palpitations that led to an abrupt loss of consciousness. After undergoing percutaneous and surgical revascularisation, he started complaining of chest and back discomfort for the past 20 years and searching for help from Chinese medicine, Fuzi. He had history of chronic renal failure and heart failure, but denied neither taking digitalis nor having family history related to sudden death.On arrival, heart rate was 150 bpm and blood pressure (BP) by cuff was 91/81 mm Hg (non-invasive BP could not be accurately obtained during tachycardia) plus oedema on both lower extremities. There were diffuse crackles and indistinct heart sounds on auscultation.The admission ECG was performed in the ER (figure 1). His serum creatinine was 139.7 mmol/L, serum K(+) was 4.7 mmol/L, N-terminal of the prohormone brain natriuretic peptide was highly elevated (12 000 pg/mL) and troponin I was negative. What is the most likely diagnosis suggested based on the patient's ECG and history? Aconite poisoningDigitalis toxicityCatecholaminergic polymorphic ventricular tachycardia (CPVT)Andersen-Tawil syndrome (ATS). Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  2. Contraceptive discontinuation and switching among couples receiving integrated HIV and family planning services in Lusaka, Zambia.

    PubMed

    Haddad, Lisa; Wall, Kristin M; Vwalika, Bellington; Khu, Naw Htee; Brill, Ilene; Kilembe, William; Stephenson, Rob; Chomba, Elwyn; Vwalika, Cheswa; Tichacek, Amanda; Allen, Susan

    2013-10-01

    To describe predictors of contraceptive method discontinuation and switching behaviours among HIV-positive couples receiving couples' voluntary HIV counselling and testing services in Lusaka, Zambia. Couples were randomized in a factorial design to two-family planning educational intervention videos, received comprehensive family planning services and were assessed every 3 months for contraceptive initiation, discontinuation and switching. We modelled factors associated with contraceptive method upgrading and downgrading via multivariate Andersen-Gill models. Most women continued the initial method selected after randomization. The highest rates of discontinuation/switching were observed for injectable contraceptive and intrauterine device users. Time to discontinuing the more effective contraceptive methods or downgrading to oral contraceptives or condoms was associated with the women's younger age, desire for more children within the next year, heavy menstrual bleeding, bleeding between periods and cystitis/dysuria. Health concerns among women about contraceptive implants and male partners not wanting more children were associated with upgrading from oral contraceptives or condoms. HIV status of the woman or the couple was not predictive of switching or stopping. We found complicated patterns of contraceptive use. The predictors of contraception switching indicate that interventions targeted to younger couples that address common contraception-related misconceptions could improve effective family planning utilization. We recommend these findings be used to increase the uptake and continuation of contraception, especially long-acting reversible contraceptive (LARC) methods, and that fertility goal based, LARC-focused family planning be offered as an integral part of HIV prevention services.

  3. Single and double acceptor-levels of a carbon-hydrogen defect in n-type silicon

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stübner, R.; Scheffler, L.; Kolkovsky, Vl., E-mail: kolkov@ifpan.edu.pl

    In the present study, we discuss the origin of two dominant deep levels (E42 and E262) observed in n-type Si, which is subjected to hydrogenation by wet chemical etching or a dc H-plasma treatment. Their activation enthalpies determined from Laplace deep level transient spectroscopy measurements are E{sub C}-0.06 eV (E42) and E{sub C}-0.51 eV (E262). The similar annealing behavior and identical depth profiles of E42 and E262 correlate them with two different charge states of the same defect. E262 is attributed to a single acceptor state due to the absence of the Poole-Frenkel effect and the lack of a capture barrier formore » electrons. The emission rate of E42 shows a characteristic enhancement with the electric field, which is consistent with the assignment to a double acceptor state. In samples with different carbon and hydrogen content, the depth profiles of E262 can be explained by a defect with one H-atom and one C-atom. From a comparison with earlier calculations [Andersen et al., Phys. Rev. B 66, 235205 (2002)], we attribute E42 to the double acceptor and E262 to the single acceptor state of the CH{sub 1AB} configuration, where one H atom is directly bound to carbon in the anti-bonding position.« less

  4. Clinical decision making for a tooth with apical periodontitis: the patients' preferred level of participation.

    PubMed

    Azarpazhooh, Amir; Dao, Thuan; Ungar, Wendy J; Chaudry, Faiza; Figueiredo, Rafael; Krahn, Murray; Friedman, Shimon

    2014-06-01

    To effectively engage patients in clinical decisions regarding the management of teeth with apical periodontitis (AP), there is a need to explore patients' perspectives on the decision-making process. This study surveyed patients for their preferred level of participation in making treatment decisions for a tooth with AP. Data were collected through a mail-out survey of 800 University of Toronto Faculty of Dentistry patients, complemented by a convenience sample of 200 patients from 10 community practices. The Control Preferences Scale was used to evaluate the patients' preferences for active, collaborative, or passive participation in treatment decisions for a tooth with AP. Using bivariate and logistic regression analyses, the Gelberg-Andersen Behavioral Model for Vulnerable Populations was applied to the Control Preferences Scale questions to understand the influential factors (P ≤ .05). Among 434 of 1,000 respondents, 44%, 40%, and 16% preferred an active, collaborative, and passive participation, respectively. Logistic regression showed a significant association (P ≤ .025) between participants' higher education and preference for active participation compared with a collaborative role. Also, immigrant status was significantly associated with preference for passive participation (P = .025). The majority of patients valued an active or collaborative participation in deciding treatment for a tooth with AP. This pattern implied a preference for a patient-centered practice mode that emphasizes patient autonomy in decision making. Copyright © 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  5. Discriminating Ability of Abbreviated Impactor Measurement Approach (AIM) to Detect Changes in Mass Median Aerodynamic Diameter (MMAD) of an Albuterol/Salbutamol pMDI Aerosol.

    PubMed

    David Christopher, J; Patel, Rajni B; Mitchell, Jolyon P; Tougas, Terrence P; Goodey, Adrian P; Quiroz, Jorge; Andersson, Patrik U; Lyapustina, Svetlana

    2017-11-01

    This article reports on results from a two-lab, multiple impactor experiment evaluating the abbreviated impactor measurement (AIM) concept, conducted by the Cascade Impaction Working Group of the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS). The goal of this experiment was to expand understanding of the performance of an AIM-type apparatus based on the Andersen eight-stage non-viable cascade impactor (ACI) for the assessment of inhalation aerosols and sprays, compared with the full-resolution version of that impactor described in the pharmacopeial compendia. The experiment was conducted at two centers with a representative commercially available pressurized metered dose inhaler (pMDI) containing albuterol (salbutamol) as active pharmaceutical ingredient (API). Metrics of interest were total mass (TM) emitted from the inhaler, impactor-sized mass (ISM), as well as the ratio of large particle mass (LPM) to small particle mass (SPM). ISM and the LPM/SPM ratio together comprise the efficient data analysis (EDA) metrics. The results of the comparison demonstrated that in this study, the AIM approach had adequate discrimination to detect changes in the mass median aerodynamic diameter (MMAD) of the ACI-sampled aerodynamic particle size distribution (APSD), and therefore could be employed for routine product quality control (QC). As with any test method considered for inclusion in a regulatory filing, the transition from an ACI (used in development) to an appropriate AIM/EDA methodology (used in QC) should be evaluated and supported by data on a product-by-product basis.

  6. Prevalence of Mental Health Problems and Associated Risk Factors among Rural-to-Urban Migrant Children in Guangzhou, China.

    PubMed

    Wang, Jun; Liu, Ke; Zheng, Jing; Liu, Jiali; You, Liming

    2017-11-14

    Rural-to-urban migration, which has achieved a huge scale during China's economic reform, is a potential risk factor for the mental health of migrant children. To test this hypothesis, this study assessed the mental health status of rural-to-urban migrant children. Guided by Andersen's behavioral model, the study explored the risk factors associated with mental health. The study recruited 1182 fifth/sixth-grade children from four private and four public primary schools in Guangzhou in 2014 in a descriptive cross-sectional design. Mental health status was measured by the strengths and difficulties questionnaire. Predisposing characteristics including demographics (e.g., age, gender), social structure (e.g., education, occupation) and health beliefs (health attitude) were recorded. Enabling characteristics including family and community resources and the need for health services were analyzed to explore the risk factors. The results indicate that more rural-to-urban migrant children were classified in the abnormal (21.0%) or borderline (18.8%) categories based on the total difficulties scores, the proportions of which were much higher than those of local children (9.8% abnormal, 13.8% borderline). Factors associated with a greater likelihood of mental health problems included single-parent families, seeking health information actively, family income cannot meet basic needs and poor perceived health status. Compared with the local children, the rural-to-urban migrant children had relatively poor mental health, hence monitoring and supporting mental health for rural-urban migrant children is critical.

  7. Assessing airborne aflatoxin B1 during on-farm grain handling activities.

    PubMed

    Selim, M I; Juchems, A M; Popendorf, W

    1998-04-01

    The presence of aflatoxin in corn and corn dust during relatively normal years and the increased risk of Aspergillus flavus infestation during drought conditions suggest that airborne agricultural exposures should be of considerable concern. Liquid extraction, thin layer chromatography, and high pressure liquid chromatography were used for the analysis of aflatoxin B1 in grain dust and bulk corn samples. A total of 24 samples of airborne dust were collected from 8 farms during harvest, 22 samples from 9 farms during animal feeding, and 14 sets of Andersen samples from 11 farms during bin cleaning. A total of 14 samples of settled dust and 18 samples of bulk corn were also collected and analyzed. The airborne concentration of aflatoxin B1 found in dust collected during harvest and grain unloading ranged from 0.04 to 92 ng/m3. Higher levels of aflatoxin B1 were found in the airborne dust samples collected from enclosed animal feeding buildings (5-421 ng/m3) and during bin cleaning (124-4849 ng/m3). Aflatoxin B1 up to 5100 ng/g were detected in settled dust collected from an enclosed animal feeding building; however, no apparent correlation was found between the airborne concentration of aflatoxin B1 and its concentration in settled dust or bulk corn. The data demonstrate that farmers and farm workers may be exposed to potentially hazardous concentrations of aflatoxin B1, particularly during bin cleaning and animal feeding in enclosed buildings.

  8. Contraceptive discontinuation and switching among couples receiving integrated HIV and family planning services in Lusaka, Zambia

    PubMed Central

    Haddad, Lisa; Wall, Kristin M; Vwalika, Bellington; Htee Khu, Naw; Brill, Ilene; Kilembe, William; Stephenson, Rob; Chomba, Elwyn; Vwalika, Cheswa; Tichacek, Amanda; Allen, Susan

    2014-01-01

    Objective To describe predictors of contraceptive method discontinuation and switching behaviors among HIV positive couples receiving couples' voluntary HIV counseling and testing services in Lusaka, Zambia. Design Couples were randomized in a factorial design to two family planning educational intervention videos, received comprehensive family planning services, and were assessed every 3-months for contraceptive initiation, discontinuation and switching. Methods We modeled factors associated with contraceptive method upgrading and downgrading via multivariate Andersen-Gill models. Results Most women continued the initial method selected after randomization. The highest rates of discontinuation/switching were observed for injectable contraceptive and intrauterine device users. Time to discontinuing the more effective contraceptive methods or downgrading to oral contraceptives or condoms was associated with the women's younger age, desire for more children within the next year, heavy menstrual bleeding, bleeding between periods, and cystitis/dysuria. Health concerns among women about contraceptive implants and male partners not wanting more children were associated with upgrading from oral contraceptives or condoms. HIV status of the woman or the couple was not predictive of switching or stopping. Conclusions We found complicated patterns of contraceptive use. The predictors of contraception switching indicate that interventions targeted to younger couples that address common contraception-related misconceptions could improve effective family planning utilization. We recommend these findings be used to increase the uptake and continuation of contraception, especially long acting reversible contraceptive (LARC) methods, and that fertility-goal based, LARC-focused family planning be offered as an integral part of HIV prevention services. PMID:24088689

  9. Polymeric nanocarriers for transport modulation across the pulmonary epithelium: dendrimers, polymeric nanoparticles, and their nanoblends.

    PubMed

    Bharatwaj, Balaji; Dimovski, Radovan; Conti, Denise S; da Rocha, Sandro R P

    2014-05-01

    The purpose of this study was to (a) Determine the cellular transport and uptake of amine-terminated generation 3 (G3) poly(amido amine) (PAMAM) dendrimers across an in vitro model of the pulmonary epithelium, and the ability to modulate their transport by forming nanoblends of the dendrimers with biodegradable solid polymeric nanoparticles (NPs) and (b) to formulate dendrimer nanocarriers in portable oral inhalation devices and evaluate their aerosol characteristics. To that end, fluorescein isothiocyanate (FITC)-labeled G3 PAMAM dendrimer nanocarriers (DNCs) were synthesized, and also encapsulated within poly lactide-co-glycolide nanoparticles (NPs). Transport and uptake of both DNCs encapsulated within NPs (nanoblends) and unencapsulated DNCs were tracked across polarized monolayers of airway epithelial cells, Calu-3. DNCs were also formulated as core-shell microparticles in pressurized metered-dose inhalers (pMDIs) and their aerodynamic properties evaluated by Andersen cascade impaction. The apparent permeability of DNCs across the airway epithelial model was similar to that of a paracellular marker of comparable molar mass--order of 10(-7) cm s(-1). The transport and cellular internalization of the DNCs can be modulated by formulating them as nanoblends. The transport of the DNCs across the lung epithelium was completely suppressed within the time of the experiment (5 h) when formulated as blends. The encapsulation also prevents saturation of the cellular internalization profile. Nanoblending may be a potential strategy to modulate the rate of transport and cellular uptake of DNCs, and thus be used as a design strategy to achieve enhanced local or systemic drug delivery.

  10. Effective Particle Size From Molecular Dynamics Simulations in Fluids

    DOE PAGES

    Ju, Jianwei; Welch, Paul Michael Jr.; Rasmussen, Kim Orskov; ...

    2017-12-08

    Here, we report molecular dynamics simulations designed to investigate the effective size of colloidal particles suspended in a fluid in the vicinity of a rigid wall where all interactions are defined by smooth atomic potential functions. These simulations are used to assess how the behavior of this system at the atomistic length scale compares to continuum mechanics models. In order to determine the effective size of the particles, we calculate the solvent forces on spherical particles of different radii as a function of different positions near and overlapping with the atomistically defined wall and compare them to continuum models. Thismore » procedure also then determines the effective position of the wall. Our analysis is based solely on forces that the particles sense, ensuring self-consistency of the method. The simulations were carried out using both Weeks–Chandler–Andersen and modified Lennard-Jones (LJ) potentials to identify the different contributions of simple repulsion and van der Waals attractive forces. Upon correction for behavior arising the discreteness of the atomic system, the underlying continuum physics analysis appeared to be correct down to much less than the particle radius. For both particle types, the effective radius was found to be ~0.75σ, where σ defines the length scale of the force interaction (the LJ diameter). The effective “hydrodynamic” radii determined by this means are distinct from commonly assumed values of 0.5σ and 1.0σ, but agree with a value developed from the atomistic analysis of the viscosity of such systems.« less

  11. Determinants of psychology service utilization in a palliative care outpatient population.

    PubMed

    Azuero, Casey; Allen, Rebecca Sue; Kvale, Elizabeth; Azuero, Andres; Parmelee, Patricia

    2014-06-01

    Research has demonstrated that treating cancer patients' psychological and physical health leads to improved overall health. This may be especially true for palliative care patients facing serious illness. This study examines the proportion and determinants of psychology service utilization in an outpatient palliative care population. Data from an existing clinical database in an outpatient palliative clinic utilizing a collaborative care model to deliver psychology services were explored. This study was framed by Andersen's Behavioral Model of Health Service Use, which incorporates three main components: predisposing, enabling, and need factors to model health service utilization. The sample (N = 149) was majority middle aged, female, and White with a primary diagnosis of cancer. Cross-tabulations were conducted to determine how many patients who met screening criteria for depression or anxiety sought psychology services. Logistic regression analyses were conducted to assess for predisposing, enabling, and need factor determinants of psychology service utilization. Among patients who met criteria for moderate depression or anxiety, 50% did not access readily available psychology services. Enabling factors were the strongest determinant of psychology utilization. Factors associated with need for psychology services (i.e., emotional distress and psychological symptom burden) did not reach significance in determining psychology service use. This study extends current knowledge about psychology utilization to palliative care outpatients receiving care within a collaborative care model. Directions for future research include further investigation of care models that optimize enabling strategies to enhance access to these services, and examination of patient-reported barriers to receiving this care. Copyright © 2013 John Wiley & Sons, Ltd.

  12. Patients’ subjective concepts about primary healthcare utilisation: the study protocol of a qualitative comparative study between Norway and Germany

    PubMed Central

    Herrmann, Wolfram J; Haarmann, Alexander; Flick, Uwe; Bærheim, Anders; Lichte, Thomas; Herrmann, Markus

    2013-01-01

    Background In Germany, utilisation of ambulatory healthcare services is high compared with other countries: While a study based on the process data of German statutory health insurances showed an average of 17.1 physician-patient-contacts per year, the comparable figure for Norway is about five. The usual models of healthcare utilisation, such as Rosenstock's Health Belief Model and Andersen's Behavioural Model, cannot explain these differences adequately. Organisational factors of the healthcare system, such as gatekeeping, do not explain the magnitude of the differences. Our hypothesis is that patients’ subjective concepts about primary healthcare utilisation play a major role in explaining different healthcare utilisation behaviour in different countries. Hence, the aim of this study is to explore these subjective concepts comparatively, between Germany and Norway. Methods/design With that aim in mind, we chose a comparative qualitative study design. In Norway and Germany, we are going to interview 20 patients each with qualitative episodic interviews. In addition, we are going to conduct participant observation in four German and four Norwegian primary care practices. The data will be analysed by thematic coding. Using selected categories, we are going to conduct comparative case and group analyses. Ethics and dissemination The study adheres to the Declaration of Helsinki. All interviewees will sign informed consent forms and all patients will be observed during consultation. Strict rules for data security will apply. Developed theory and policy implications are going to be disseminated by a workshop, presentations for experts and laypersons and publications. PMID:23794555

  13. Does Cost-Related Medication Nonadherence among Cardiovascular Disease Patients Vary by Gender? Evidence from a Nationally Representative Sample.

    PubMed

    Bhuyan, Soumitra S; Shiyanbola, Olayinka; Kedia, Satish; Chandak, Aastha; Wang, Yang; Isehunwa, Oluwaseyi O; Anunobi, Nnamdi; Ebuenyi, Ikenna; Deka, Pallav; Ahn, SangNam; Chang, Cyril F

    Cardiovascular disease (CVD) is a leading cause of death and disability as well as a major burden on the U.S. healthcare system. Cost-related medication nonadherence (CRN) to prescribed medications is common among patients with CVD. This study examines the gender differences in CRN among CVD patients. We used 2011 to 2014 data from the National Health Interview Survey, an annual, cross-sectional, nationally representative household survey of the noninstitutionalized U.S. civilian population (≥18 years of age). Based on Andersen's model of health services utilization, multivariate logistic regressions were estimated to examine the effect of gender on the primary composite outcome of CRN which was identified if any of the following types of CRN were reported: 1) skipped medication doses to save money, 2) took less medication to save money, and 3) delayed prescription filling to save money. Among CVD patients who had used a prescription medication in the last 12 months, 10.0% skipped medication doses, 10.6% took less medication, and 12.8% delayed filling their prescriptions. After adjusting for confounding factors, gender was found to be significantly associated with the composite outcome of CRN among CVD patients. Women were 1.54 times (95% confidence interval, 1.33-1.77) more likely to have any of the types of CRN compared with men. There are significant gender disparities in CRN among CVD patients. More support for and closer monitoring of CRN is needed for disadvantaged groups, especially women with limited resources. Copyright © 2016 Jacobs Institute of Women's Health. Published by Elsevier Inc. All rights reserved.

  14. Physical therapists familiarity and beliefs about health services utilization and health seeking behaviour.

    PubMed

    Clewley, Derek; Rhon, Dan; Flynn, Tim; Koppenhaver, Shane; Cook, Chad

    2018-02-21

    Physical therapists' familiarity, perceptions, and beliefs about health services utilization and health seeking behaviour have not been previously assessed. The purposes of this study were to identify physical therapists' characteristics related to familiarity of health services utilization and health seeking behaviour, and to assess what health seeking behaviour factors providers felt were related to health services utilization. We administered a survey based on the Andersen behavioural model of health services utilization to physical therapists using social media campaigns and email between March and June of 2017. In addition to descriptive statistics, we performed binomial logistic regression analysis. We asked respondents to rate familiarity with health services utilization and health seeking behaviour and collected additional characteristic variables. Physical therapists are more familiar with health services utilization than health seeking behaviour. Those who are familiar with either construct tend to be those who assess for health services utilization, use health services utilization for a prognosis, and believe that health seeking behaviour is measurable. Physical therapists rated need and enabling factors as having more influence on health services utilization than predisposing and health belief factors. Physical therapists are generally familiar with health services utilization and health seeking behaviour; however, there appears to be a disconnect between what is familiar, what is perceived to be important, and what can be assessed for both health services utilization and health seeking behaviour. Copyright © 2018 Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia. All rights reserved.

  15. Dry powder inhalers of gentamicin and leucine: formulation parameters, aerosol performance and in vitro toxicity on CuFi1 cells.

    PubMed

    Aquino, R P; Prota, L; Auriemma, G; Santoro, A; Mencherini, T; Colombo, G; Russo, P

    2012-04-15

    The high hygroscopicity of gentamicin (G) as raw material hampers the production of respirable particles during aerosol generation and prevents its direct use as powder for inhalation in patients suffering from cystic fibrosis (CF). Therefore, this research aimed to design a new dry powder formulation of G studying dispersibility properties of an aminoacid, L-leucine (leu), and appropriate process conditions. Spray-dried powders were characterized as to water uptake, particle size distribution, morphology and stability, in correlation with process parameters. Aerodynamic properties were analyzed both by Single Stage Glass Impinger and Andersen Cascade Impactor. Moreover, the potential cytotoxicity on bronchial epithelial cells bearing a CFTR F508/F508 mutant genotype (CuFi1) were tested. Results indicated that leu may improve the aerosol performance of G-dried powders. The maximum fine particle fraction (FPF) of about 58.3% was obtained when water/isopropyl alcohol 7:3 system and 15-20% (w/w) of leu were used, compared to a FPF value of 13.4% for neat G-dried powders. The enhancement of aerosol efficiency was credited both to the improvement of the powder flowability, caused by the dispersibility enhancer (aminoacid), and to the modification of the particle surface due to the influence of the organic co-solvent on drying process. No significant degradation of the dry powder was observed up to 6 months of storage. Moreover, particle engineering did not affect either the cell viability or cell proliferation of CuFi1 over a 24 h period. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. Characterizing hydrophobicity of amino acid side chains in a protein environment via measuring contact angle of a water nanodroplet on planar peptide network

    PubMed Central

    Zhu, Chongqin; Gao, Yurui; Li, Hui; Meng, Sheng; Li, Lei; Francisco, Joseph S.; Zeng, Xiao Cheng

    2016-01-01

    Hydrophobicity of macroscopic planar surface is conventionally characterized by the contact angle of water droplets. However, this engineering measurement cannot be directly extended to surfaces of proteins, due to the nanometer scale of amino acids and inherent nonplanar structures. To measure the hydrophobicity of side chains of proteins quantitatively, numerous parameters were developed to characterize behavior of hydrophobic solvation. However, consistency among these parameters is not always apparent. Herein, we demonstrate an alternative way of characterizing hydrophobicity of amino acid side chains in a protein environment by constructing a monolayer of amino acids (i.e., artificial planar peptide network) according to the primary and the β-sheet secondary structures of protein so that the conventional engineering measurement of the contact angle of a water droplet can be brought to bear. Using molecular dynamics simulations, contact angles θ of a water nanodroplet on the planar peptide network, together with excess chemical potentials of purely repulsive methane-sized Weeks−Chandler−Andersen solute, are computed. All of the 20 types of amino acids and the corresponding planar peptide networks are studied. Expectedly, all of the planar peptide networks with nonpolar amino acids are hydrophobic due to θ > 90°, whereas all of the planar peptide networks of the polar and charged amino acids are hydrophilic due to θ < 90°. Planar peptide networks of the charged amino acids exhibit complete-wetting behavior due to θ = 0°. This computational approach for characterization of hydrophobicity can be extended to artificial planar networks of other soft matter. PMID:27803319

  17. Position-Specific Acceleration and Deceleration Profiles in Elite Youth and Senior Soccer Players.

    PubMed

    Vigh-Larsen, Jeppe F; Dalgas, Ulrik; Andersen, Thomas B

    2018-04-01

    Vigh-Larsen, JF, Dalgas, U, and Andersen, TB. Position-specific acceleration and deceleration profiles in elite youth and senior soccer players. J Strength Cond Res 32(4): 1114-1122, 2018-The purpose of the study was to characterize and compare the position-specific activity profiles of young and senior elite soccer players with special emphasis put on accelerations and decelerations. Eight professional senior matches were tracked using the ZXY tracking system and analyzed for the number of accelerations and decelerations and running distances within different speed zones. Likewise, 4 U19 and 5 U17 matches were analyzed for comparison between youth and senior players. In senior players, the total distance (TD) was 10,776 ± 107 m with 668 ± 28 and 143 ± 10 m being high-intensity running (HIR) and sprinting, respectively. Number of accelerations and decelerations were 81 ± 2 and 84 ± 3, respectively, with central defenders performing the lowest and wide players the highest number. Declines were found between first and second halves for accelerations and decelerations (11 ± 3%), HIR (6 ± 4%), and TD (5 ± 1%), whereas sprinting distance did not differ. U19 players performed a higher number of accelerations, decelerations, and TD compared with senior players. In conclusion, differences in the number and distribution of accelerations and decelerations appeared between player positions, which is of importance when monitoring training and match loads and when prescribing specific training exercises. Furthermore, youth players performed as much high-intensity activities as senior players, indicating that this is not a discriminating physiological parameter between these players.

  18. Factors associated with utilization of maternal serum screening for Down syndrome in mainland China: a cross-sectional study.

    PubMed

    Li, Chuanlin; Shi, Leiyu; Huang, Jiayan; Qian, Xu; Chen, Yingyao

    2016-01-14

    Knowledge of the factors that influence maternal serum screening (MSS) service utilization can be used to develop health policies to promote equitable access to MSS and further diagnostic tests. The purpose of this study was to find the factors associated with utilization of MSS as well as the current status of service utilization in mainland China. This was a hospital-based cross-sectional study with respondents interviewed with a questionnaire designed based on Andersen's behavioral model. Descriptive statistics, univariate analysis, and multilevel logistic regression analysis were used to identify the factors associated with MSS utilization, and to explore potential methods to improve screening uptake. A total of 8110 women who had given birth within the previous 7 days in one of 111 participating institutions from six provinces in mainland China were interviewed. Approximately 36% of the participants had used MSS. Women between 20 and 35 years, who resided in urban areas, were educated, were in a stable occupation, who had health knowledge, who attended maternal preparation classes, who had received eight or more prenatal checkups, who were from a region of higher social economic status, and who delivered in a tertiary healthcare institution were significantly more likely to use MSS than their counterparts. As compared with other factors, insufficient education is the single most important demographic factor for service underutilization. Efforts should not only be made to target the population that underuses MSS, but the overall organization of MSS service delivery should be assessed during policy development to make access to MSS equitable to the entire population of mainland China.

  19. Costs and deaths of landslides in Europe

    NASA Astrophysics Data System (ADS)

    Haque, Ubydul; Blum, Philipp

    2016-04-01

    Landslides cause human and large economic losses worldwide and also in Europe. However, the quantification of associated costs and deaths is highly underestimated and still incomplete, thus the estimation of landslide costs and risk is still rather ambitious. Hence, in this study a spatio-temporal analysis of fatal landslides is presented for 27 European countries from 1995-2014. These landslides are mainly concentrated in mountainous areas. A total of 1370 fatalities are reported resulting from 476 landslides. The highest fatalities with 335 are observed in Turkey. In general, an increasing trend of fatal landslides is recognized starting in 2008. The latter is almost certainly triggered by an increase in natural extreme events such as storms (i.e. heavy rainfall) and floods. The highest annual economic loss is observed in Italy with 3.9 billion Euro per year. In contrast, in Germany the annual total loss is only about 0.3 billion Euro. The results of this study serves as an initial baseline information for further risk studies integrating landslide locations, local land use data, cost data, and will therefore certainly support the studied countries to better protect their citizens and assets. Acknowledgements We would like to acknowledge the valuable contributions by Paula F. da Silva, Peter Andersen, Jürgen Pilz, Ali Ardalan, Sergey R. Chalov, Jean-Philippe Malet, Mateja Jemec Auflič, Norina Andres, Eleftheria Poyiadji, Pedro C. Lamas, Wenyi Zhang, Igor Pesevski, Halldór G. Pétursson, Tayfun Kurt, Nikolai Dobrev, Juan Carlos García Davalillo, Matina Halkia, Stefano Ferri, George Gaprindashvili, Johanna Engström and David Keellings.

  20. Characteristics of bacterial and fungal aerosols during the autumn haze days in Xi'an, China

    NASA Astrophysics Data System (ADS)

    Li, Yanpeng; Fu, Honglei; Wang, Wei; Liu, Jun; Meng, Qinglong; Wang, Wenke

    2015-12-01

    In recent years, haze pollution has become one of the most critical environmental issues in Xi'an, China, with particular matter (PM) being one of the top pollutants. As an important fraction of PM, bioaerosols may have adverse effects on air quality and human health. In this study, to better understand the characteristics of such biological aerosols, airborne microbial samples were collected by using an Andersen six-stage sampler in Xi'an from October 8th to 22nd, 2014. The concentration, size distribution and genera of airborne viable bacteria and fungi were comparably investigated during the haze days and non-haze days. Correlations of bioaerosol levels with meteorological parameters and PM concentrations were also examined. The results showed that the daily average concentrations of airborne viable bacteria and fungi during the haze days, 1102.4-1736.5 and 1466.2-1703.9 CFU/m3, respectively, were not only much higher than those during the non-haze days, but also exceeded the recommended permissible limit values. Comparing to size distributions during the non-haze days, slightly different patterns for bacterial aerosols and similar single-peak distribution pattern for fungal aerosols were observed during the haze days. Moreover, more allergic and infectious genera (e.g. Neisseria, Aspergillus, and Paecilomyces) in bioaerosols were identified during the haze days than during non-haze days. The present results reveal that bioaerosols may have more significant effects on public health and urban air quality during the haze days than during non-haze days.

  1. Assessing the role of appropriate primary health care on the use of dental services by Brazilian low-income preschool children.

    PubMed

    Baldani, Márcia Helena; Rocha, Juliana Schaia; Fadel, Cristina Berger; Nascimento, Antonio Carlos; Antunes, José Leopoldo Ferreira; Moysés, Samuel Jorge

    2017-11-21

    This cross-sectional study aimed to assess the association between the quality of primary health care (PHC) and the use of dental services by preschoolers served by the Family Health Strategy (FHS), controlling for socio-demographic determinants and perceived need. The sample encompassed 438 children aged 3-5 years, enrolled in 19 FHS facilities in Ponta Grossa, Paraná State, Brazil. Individual level variables were collected by interviewing parents or caregivers at home. They answered a questionnaire on socioeconomic conditions, oral hygiene habits and use of dental services. Parental perception of child's oral health related quality of life, as perceived need, was assessed by the Brazilian version of Early Childhood Oral Health Impact Scale (ECOHIS). Normative need was assessed by oral examinations, according to guidelines standardized by the World Health Organization. The contextual level factor was defined as the extent of implementation of PHC in the facilities. Managers responded to PCATool-Brazil, a validated questionnaire which measures the extent of PHC. Dentists answered to a version of PCATool, which was adapted and pretested for dental services. Multilevel analysis, based on Andersen's behavioral model, fitted the adjustment of "having ever consulted a dentist" to contextual and individual covariates. We observed high prevalence of dental caries. Almost half of the sample had had dental appointments in life. Social gradients were observed for the use of dental services. Although it was not able to eliminate the impact of adverse social conditions, higher levels of PHC attributes in dental services favored the effective use of such services by low-income children.

  2. The influence of welfare systems on pay-for-performance programs for general practitioners: A critical review.

    PubMed

    Ammi, Mehdi; Fortier, Grant

    2017-04-01

    While pay-for-performance (P4P) programs are increasingly common tools used to foster quality and efficiency in primary care, the evidence concerning their effectiveness is at best mixed. In this article, we explore the influence of welfare systems on four P4P-related dimensions: the level of healthcare funders' commitment to P4Ps (by funding and length of program operation), program design (specifically target-based vs. participation-based program), physicians' acceptance of the program and program effects. Using Esping-Andersen's typology, we examine P4P for general practitioners (GPs) in thirteen European and North American countries and find that welfare systems contribute to explain variations in P4P experiences. Overall, liberal systems exhibited the most enthusiastic adoption of P4P, with significant physician acceptance, generous incentives and positive but modest program effects. Social democratic countries showed minimal interest in P4P for GPs, with the exception of Sweden. Although corporatist systems adopted performance pay, these countries experienced mixed results, with strong physician opposition. In response to this opposition, health care funders tended to favour participation-based over target-based P4P. We demonstrate how the interaction of decommodification and social stratification in each welfare regime influences these countries' experiences with P4P for GPs, directly for funders' commitment, program design and physicians' acceptance, and indirectly for program effects, hence providing a framework for analyzing P4P in other contexts or care settings. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Racial-ethnic variation in U.S. mental health service use among Latino and Asian non-U.S. citizens.

    PubMed

    Lee, Sungkyu; Laiewski, Laurel; Choi, Sunha

    2014-01-01

    This study examined the factors associated with service utilization for mental health conditions among Latino and Asian non-U.S. citizens in the United States by service type and race. Data were obtained from the National Latino and Asian American Study (NLAAS). The sample for this study was 849 Latino and 595 Asian non-U.S. citizens between ages 18 and 64 (N=1,444). Mental health services obtained through three types of service providers were examined: specialty mental health services, general medical services, and other services. Guided by the modified Andersen health behavioral model, analyses involved logistic regression models conducted with penalized maximum likelihood estimation. Although having a psychiatric disorder increased mental health service use in both groups, only 32% of Latino and 52% of Asian non-U.S. citizens with psychiatric needs reported using mental health services during the past 12 months. Overall, noncitizen Latinos and Asians were more likely to use mental health services from general health care providers and other providers than from specialty mental health providers. Several significant predisposing, enabling, and need factors, such as age, health insurance, and having psychiatric conditions, also interacted with race. Findings of the study suggest that there are ethnoracial variations in mental health service use between Latino and Asian non-U.S. citizens. Mental health professionals should consider developing tailored mental health interventions that account for cultural variations to enhance access to services for these vulnerable subgroups of Latinos and Asians. Further research should examine ethnic disparities in mental health service use among various non-U.S. citizen racial-ethnic subgroups.

  4. Determinants of individuals' participation in integrated chronic disease screening in Singapore.

    PubMed

    Venkataraman, Kavita; Wee, Hwee Lin; Ng, Sheryl Hui Xian; Rebello, Salome; Tai, E Shyong; Lee, Jeannette; Tan, Chuen Seng

    2016-06-10

    A large pool of patients with chronic diseases remains undiagnosed globally and in Singapore. We explored factors associated with participation in a health screening exercise, using revealed preference, that is, actual attendance, to understand why people remain undiagnosed with chronic diseases. A cross-sectional, community-based sample of Singapore residents was invited to participate in home interviews, and subsequently to attend centre-based health screening, between 2004 and 2007. Determinants of health screening participation were identified using logistic regression models based on Andersen's Behavioral Model. Of the 6366 participants who completed health interview, 4092 attended the health screening, while 2274 did not. Older age, Chinese or Indian ethnicity, higher education levels, greater intake of monounsaturated fat, greater transport and leisure-time physical activity were the key predisposing factors associated with greater health screening participation. Greater family cohesion was the key associated enabling factor, while previous diagnosis of dyslipidaemia or musculoskeletal conditions, absence of previously diagnosed diabetes or hypertension and lower perceived physical health were the associated need factors. Our study suggests that ethnicity, education, family cohesion, healthy behaviour patterns and perceived physical health status were key determinants of health screening participation. Enhancing the cultural competence of preventive health services may help increase participation of these groups in screening efforts and reduce the proportions of undiagnosed chronic disease in the community. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  5. Statistical modelling for recurrent events: an application to sports injuries

    PubMed Central

    Ullah, Shahid; Gabbett, Tim J; Finch, Caroline F

    2014-01-01

    Background Injuries are often recurrent, with subsequent injuries influenced by previous occurrences and hence correlation between events needs to be taken into account when analysing such data. Objective This paper compares five different survival models (Cox proportional hazards (CoxPH) model and the following generalisations to recurrent event data: Andersen-Gill (A-G), frailty, Wei-Lin-Weissfeld total time (WLW-TT) marginal, Prentice-Williams-Peterson gap time (PWP-GT) conditional models) for the analysis of recurrent injury data. Methods Empirical evaluation and comparison of different models were performed using model selection criteria and goodness-of-fit statistics. Simulation studies assessed the size and power of each model fit. Results The modelling approach is demonstrated through direct application to Australian National Rugby League recurrent injury data collected over the 2008 playing season. Of the 35 players analysed, 14 (40%) players had more than 1 injury and 47 contact injuries were sustained over 29 matches. The CoxPH model provided the poorest fit to the recurrent sports injury data. The fit was improved with the A-G and frailty models, compared to WLW-TT and PWP-GT models. Conclusions Despite little difference in model fit between the A-G and frailty models, in the interest of fewer statistical assumptions it is recommended that, where relevant, future studies involving modelling of recurrent sports injury data use the frailty model in preference to the CoxPH model or its other generalisations. The paper provides a rationale for future statistical modelling approaches for recurrent sports injury. PMID:22872683

  6. Heavy metals in atmospheric surrogate dry deposition

    PubMed

    Morselli; Cecchini; Grandi; Iannuccilli; Barilli; Olivieri

    1999-02-01

    This paper describes a methodological approach for the assessment of the amount of surrogate dry deposition of several toxic heavy metals (Cd, Cr, Cu, Ni, Pb, V, Zn) associated with atmospheric particulate matter at ground level. The objectives of the study were twofold: i) the evaluation of several techniques for the digestion of dry deposition samples for trace metal analysis; ii) the comparison of the results from two samplers with different collecting surfaces. A dry solid surface sampler (DRY sampler, Andersen--USA) and a water layer surface sampler (DAS sampler--MTX Italy) were employed. The samples were collected over a one-year period in an urban site of Bologna (northern Italy). A description is given of the complete procedure, from sampling to data elaboration, including sample storage, digestion and analytical methods. According to the results obtained with three different digestion techniques (Teflon bomb, microwave digester and Teflon flask with vapour cooling system), the highest recovery rate was achieved by the Teflon bomb procedure employing an NBS 1648 Standard Reference Material; 90-95% of the elements considered were recovered by dissolution in a pressurized Teflon bomb with an HNO3-HF mixture. Given these results, the technique was adopted for dry deposition sample digestion. On the basis of the amount of heavy metals measured as monthly deposition fluxes (microg/m2), the collecting efficiency of the DAS sampler for a number of elements was found to be as much as two to three times greater than that of the DRY sampler.

  7. The post-trial effect of oral periodic presumptive treatment for vaginal infections on the incidence of bacterial vaginosis and Lactobacillus colonization

    PubMed Central

    Balkus, Jennifer E.; Jaoko, Walter; Mandaliya, Kishorchandra; Richardson, Barbra A.; Masese, Linnet; Gitau, Ruth; Kiarie, James; Marrazzo, Jeanne; Farquhar, Carey; McClelland, R. Scott

    2012-01-01

    Background We previously demonstrated a decrease in bacterial vaginosis (BV) and an increase in Lactobacillus colonization among randomized controlled trial (RCT) participants who received monthly oral periodic presumptive treatment (PPT) [2g metronidazole + 150mg fluconazole]. Post-trial data were analyzed to test the hypothesis that the treatment effect would persist following completion of one year of PPT. Methods Data were obtained from women who completed all 12 RCT visits and attended ≥1 post-trial visit within 120 days following completion of the RCT. We used Andersen-Gill proportional hazards models to estimate the post-trial effect of the intervention on the incidence of BV by Gram stain and detection of Lactobacillus species by culture. Results The analysis included 165 subjects (83 active and 82 placebo). The post-trial incidence of BV was 260 per 100 person-years in the intervention arm versus 358 per 100 person-years in the placebo arm (hazard ratio [HR]=0.76; 95% confidence interval [CI]: 0.51–1.12). The post-trial incidence of Lactobacillus colonization was 180 per 100 person-years in the intervention arm versus 127 per 100 person-years in the placebo arm (HR=1.42; 95% CI: 0.85–2.71). Conclusions Despite a decrease in BV and an increase in Lactobacillus colonization during the RCT, the effect of PPT was not sustained at the same level following cessation of the intervention. New interventions that reduce BV recurrence and promote Lactobacillus colonization without the need for ongoing treatment are needed. PMID:22504600

  8. Effective particle size from molecular dynamics simulations in fluids

    NASA Astrophysics Data System (ADS)

    Ju, Jianwei; Welch, Paul M.; Rasmussen, Kim Ø.; Redondo, Antonio; Vorobieff, Peter; Kober, Edward M.

    2018-04-01

    We report molecular dynamics simulations designed to investigate the effective size of colloidal particles suspended in a fluid in the vicinity of a rigid wall where all interactions are defined by smooth atomic potential functions. These simulations are used to assess how the behavior of this system at the atomistic length scale compares to continuum mechanics models. In order to determine the effective size of the particles, we calculate the solvent forces on spherical particles of different radii as a function of different positions near and overlapping with the atomistically defined wall and compare them to continuum models. This procedure also then determines the effective position of the wall. Our analysis is based solely on forces that the particles sense, ensuring self-consistency of the method. The simulations were carried out using both Weeks-Chandler-Andersen and modified Lennard-Jones (LJ) potentials to identify the different contributions of simple repulsion and van der Waals attractive forces. Upon correction for behavior arising the discreteness of the atomic system, the underlying continuum physics analysis appeared to be correct down to much less than the particle radius. For both particle types, the effective radius was found to be ˜ 0.75σ , where σ defines the length scale of the force interaction (the LJ diameter). The effective "hydrodynamic" radii determined by this means are distinct from commonly assumed values of 0.5σ and 1.0σ , but agree with a value developed from the atomistic analysis of the viscosity of such systems.

  9. Computing the Viscosity of Supercooled Liquids: Markov Network Model

    PubMed Central

    Li, Ju; Kushima, Akihiro; Eapen, Jacob; Lin, Xi; Qian, Xiaofeng; Mauro, John C.; Diep, Phong; Yip, Sidney

    2011-01-01

    The microscopic origin of glass transition, when liquid viscosity changes continuously by more than ten orders of magnitude, is challenging to explain from first principles. Here we describe the detailed derivation and implementation of a Markovian Network model to calculate the shear viscosity of deeply supercooled liquids based on numerical sampling of an atomistic energy landscape, which sheds some light on this transition. Shear stress relaxation is calculated from a master-equation description in which the system follows a transition-state pathway trajectory of hopping among local energy minima separated by activation barriers, which is in turn sampled by a metadynamics-based algorithm. Quantitative connection is established between the temperature variation of the calculated viscosity and the underlying potential energy and inherent stress landscape, showing a different landscape topography or “terrain” is needed for low-temperature viscosity (of order 107 Pa·s) from that associated with high-temperature viscosity (10−5 Pa·s). Within this range our results clearly indicate the crossover from an essentially Arrhenius scaling behavior at high temperatures to a low-temperature behavior that is clearly super-Arrhenius (fragile) for a Kob-Andersen model of binary liquid. Experimentally the manifestation of this crossover in atomic dynamics continues to raise questions concerning its fundamental origin. In this context this work explicitly demonstrates that a temperature-dependent “terrain” characterizing different parts of the same potential energy surface is sufficient to explain the signature behavior of vitrification, at the same time the notion of a temperature-dependent effective activation barrier is quantified. PMID:21464988

  10. The increasing use of theory in social gerontology: 1990-2004.

    PubMed

    Alley, Dawn E; Putney, Norella M; Rice, Melissa; Bengtson, Vern L

    2010-09-01

    To determine how often theory is used in published research in social gerontology, compare theory use over a 10-year period (1990-1994 to 2000-2004), and identify the theories most frequently used in social gerontology research. Systematic review of articles published in eight leading journals from 2000 to 2004 (N = 1,046) and comparison with a review conducted 10 years earlier. Theory was mentioned in 39% of articles published from 2000 to 2004, representing a 12% increase in the use of theory over 10 years. This increase was driven by theories outside the core sociology of aging theories identified by Bengtson, V. L., Burgess, E. O., and Parrott, T. M. (1997). Theory, explanation, and a third generation of theoretical development in social gerontology. Journal of Gerontology: Social Sciences, 52B, S72-S88. The five most frequently used theories included the life course perspective, life-span developmental theories, role theory, exchange theory, and person-environment theory/ecological theories of aging. Commonly used models included stress process/stress and coping models, successful aging models, the Andersen behavioral model of health services use, models of control/self-efficacy/mastery, and disablement process models. Theory use in social gerontology increased between 1990 and 2004, with a shift toward theories that cross disciplines. However, the majority of research in social gerontology continues to be atheoretical. Models are widely used as a supplement to or substitute for theory. Many of these models are currently being debated and elaborated, and over time, they may emerge as important theoretical contributions to social gerontology.

  11. A Framework for the Next Generation of Risk Science

    PubMed Central

    Krewski, Daniel; Andersen, Melvin E.; Paoli, Gregory M.; Chiu, Weihsueh A.; Al-Zoughool, Mustafa; Croteau, Maxine C.; Burgoon, Lyle D.; Cote, Ila

    2014-01-01

    Objectives: In 2011, the U.S. Environmental Protection Agency initiated the NexGen project to develop a new paradigm for the next generation of risk science. Methods: The NexGen framework was built on three cornerstones: the availability of new data on toxicity pathways made possible by fundamental advances in basic biology and toxicological science, the incorporation of a population health perspective that recognizes that most adverse health outcomes involve multiple determinants, and a renewed focus on new risk assessment methodologies designed to better inform risk management decision making. Results: The NexGen framework has three phases. Phase I (objectives) focuses on problem formulation and scoping, taking into account the risk context and the range of available risk management decision-making options. Phase II (risk assessment) seeks to identify critical toxicity pathway perturbations using new toxicity testing tools and technologies, and to better characterize risks and uncertainties using advanced risk assessment methodologies. Phase III (risk management) involves the development of evidence-based population health risk management strategies of a regulatory, economic, advisory, community-based, or technological nature, using sound principles of risk management decision making. Conclusions: Analysis of a series of case study prototypes indicated that many aspects of the NexGen framework are already beginning to be adopted in practice. Citation: Krewski D, Westphal M, Andersen ME, Paoli GM, Chiu WA, Al-Zoughool M, Croteau MC, Burgoon LD, Cote I. 2014. A framework for the next generation of risk science. Environ Health Perspect 122:796–805; http://dx.doi.org/10.1289/ehp.1307260 PMID:24727499

  12. Effective Particle Size From Molecular Dynamics Simulations in Fluids

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ju, Jianwei; Welch, Paul Michael Jr.; Rasmussen, Kim Orskov

    Here, we report molecular dynamics simulations designed to investigate the effective size of colloidal particles suspended in a fluid in the vicinity of a rigid wall where all interactions are defined by smooth atomic potential functions. These simulations are used to assess how the behavior of this system at the atomistic length scale compares to continuum mechanics models. In order to determine the effective size of the particles, we calculate the solvent forces on spherical particles of different radii as a function of different positions near and overlapping with the atomistically defined wall and compare them to continuum models. Thismore » procedure also then determines the effective position of the wall. Our analysis is based solely on forces that the particles sense, ensuring self-consistency of the method. The simulations were carried out using both Weeks–Chandler–Andersen and modified Lennard-Jones (LJ) potentials to identify the different contributions of simple repulsion and van der Waals attractive forces. Upon correction for behavior arising the discreteness of the atomic system, the underlying continuum physics analysis appeared to be correct down to much less than the particle radius. For both particle types, the effective radius was found to be ~0.75σ, where σ defines the length scale of the force interaction (the LJ diameter). The effective “hydrodynamic” radii determined by this means are distinct from commonly assumed values of 0.5σ and 1.0σ, but agree with a value developed from the atomistic analysis of the viscosity of such systems.« less

  13. Inequalities in dental services utilization among Brazilian low-income children: the role of individual determinants.

    PubMed

    Baldani, Marcia Helena; Mendes, Yasmine Bittencourt Emílio; Lawder, Juliana Aparecida de Campos; de Lara, Ana Paula Ingles; Rodrigues, Michelli Marta Azevedo da Silva; Antunes, Jose Leopoldo Ferreira

    2011-01-01

    To assess the role of the individual determinants on the inequalities of dental services utilization among low-income children living in the working area of Brazilian's federal Primary Health Care program, which is called Family Health Program (FHP), in a big city in Southern Brazil. A cross-sectional population-based study was performed. The sample included 350 children, ages 0 to 14 years, whose parents answered a questionnaire about their socioeconomic conditions, perceived needs, oral hygiene habits, and access to dental services. The data analysis was performed according to a conceptual framework based on Andersen's behavioral model of health services use. Multivariate models of logistic regression analysis instructed the hypothesis on covariates for never having had a dental visit. Thirty one percent of the surveyed children had never had a dental visit. In the bivariate analysis, higher proportion of children who had never had a dental visit was found among the very young, those with inadequate oral hygiene habits, those without perceived need of dental care, and those whose family homes were under absent ownership. The mechanisms of social support showed to be important enabling factors: children attending schools/kindergartens and being regularly monitored by the FHP teams had higher odds of having gone to the dentist, even after adjusting for socioeconomic, demographic, and need variables. The conceptual framework has confirmed the presence of social and psychosocial inequalities on the utilization pattern of dental services for low-income children. The individual determinants seem to be important predictors of access.

  14. XMAP310: A Xenopus Rescue-promoting Factor Localized to the Mitotic Spindle

    PubMed Central

    Andersen, Søren S.L.; Karsenti, Eric

    1997-01-01

    To understand the role of microtubule-associated proteins (MAPs) in the regulation of microtubule (MT) dynamics we have characterized MAPs prepared from Xenopus laevis eggs (Andersen, S.S.L., B. Buendia, J.E. Domínguez, A. Sawyer, and E. Karsenti. 1994. J. Cell Biol. 127:1289–1299). Here we report on the purification and characterization of a 310-kD MAP (XMAP310) that localizes to the nucleus in interphase and to mitotic spindle MTs in mitosis. XMAP310 is present in eggs, oocytes, a Xenopus tissue culture cell line, testis, and brain. We have purified XMAP310 to homogeneity from egg extracts. The purified protein cross-links pure MTs. Analysis of the effect of this protein on MT dynamics by time-lapse video microscopy has shown that it increases the rescue frequency 5–10-fold and decreases the shrinkage rate twofold. It has no effect on the growth rate or the catastrophe frequency. Microsequencing data suggest that XMAP230 and XMAP310 are novel MAPs. Although the three Xenopus MAPs characterized so far, XMAP215 (Vasquez, R.J., D.L. Gard, and L. Cassimeris. 1994. J. Cell Biol. 127:985–993), XMAP230, and XMAP310 are localized to the mitotic spindle, they have distinct effects on MT dynamics. While XMAP215 promotes rapid MT growth, XMAP230 decreases the catastrophe frequency and XMAP310 increases the rescue frequency. This may have important implications for the regulation of MT dynamics during spindle morphogenesis and chromosome segregation. PMID:9362515

  15. Airborne bacteria and fungi associated with waste-handling work.

    PubMed

    Park, Donguk; Ryu, Seunghun; Kim, Shinbum; Byun, Hyaejeong; Yoon, Chungsik; Lee, Kyeongmin

    2013-01-01

    Municipal workers handling household waste are potentially exposed to a variety of toxic and pathogenic substances, in particular airborne bacteria, gram-negative bacteria (GNB), and fungi. However, relatively little is known about the conditions under which exposure is facilitated. This study assessed levels of airborne bacteria, GNB, and fungi, and examined these in relation to the type of waste-handling activity (collection, transfer, transport, and sorting at the waste preprocessing plant), as well as a variety of other environmental and occupational factors. Airborne microorganisms were sampled using an Andersen single-stage sampler equipped with agar plates containing the appropriate nutritional medium and then cultured to determine airborne levels. Samples were taken during collection, transfer, transport, and sorting of household waste. Multiple regression analysis was used to identify environmental and occupational factors that significantly affect airborne microorganism levels during waste-handling activities. The "type of waste-handling activity" was the only factor that significantly affected airborne levels of bacteria and GNB, accounting for 38% (P = 0.029) and 50% (P = 0.0002) of the variation observed in bacteria and GNB levels, respectively. In terms of fungi, the type of waste-handling activity (R2 = 0.76) and whether collection had also occurred on the day prior to sampling (P < 0.0001, R2 = 0.78) explained most of the observed variation. Given that the type of waste-handling activity was significantly correlated with levels of bacteria, GNB, and fungi, we suggest that various engineering, administrative, and regulatory measures should be considered to reduce the occupational exposure to airborne microorganisms in the waste-handling industry.

  16. Time-to-first-event versus recurrent-event analysis: points to consider for selecting a meaningful analysis strategy in clinical trials with composite endpoints.

    PubMed

    Rauch, Geraldine; Kieser, Meinhard; Binder, Harald; Bayes-Genis, Antoni; Jahn-Eimermacher, Antje

    2018-05-01

    Composite endpoints combining several event types of clinical interest often define the primary efficacy outcome in cardiologic trials. They are commonly evaluated as time-to-first-event, thereby following the recommendations of regulatory agencies. However, to assess the patient's full disease burden and to identify preventive factors or interventions, subsequent events following the first one should be considered as well. This is especially important in cohort studies and RCTs with a long follow-up leading to a higher number of observed events per patients. So far, there exist no recommendations which approach should be preferred. Recently, the Cardiovascular Round Table of the European Society of Cardiology indicated the need to investigate "how to interpret results if recurrent-event analysis results differ […] from time-to-first-event analysis" (Anker et al., Eur J Heart Fail 18:482-489, 2016). This work addresses this topic by means of a systematic simulation study. This paper compares two common analysis strategies for composite endpoints differing with respect to the incorporation of recurrent events for typical data scenarios motivated by a clinical trial. We show that the treatment effects estimated from a time-to-first-event analysis (Cox model) and a recurrent-event analysis (Andersen-Gill model) can systematically differ, particularly in cardiovascular trials. Moreover, we provide guidance on how to interpret these results and recommend points to consider for the choice of a meaningful analysis strategy. When planning trials with a composite endpoint, researchers, and regulatory agencies should be aware that the model choice affects the estimated treatment effect and its interpretation.

  17. Coarse-grained molecular dynamics simulations of depletion-induced interactions for soft matter systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shendruk, Tyler N., E-mail: tyler.shendruk@physics.ox.ac.uk; Bertrand, Martin; Harden, James L.

    2014-12-28

    Given the ubiquity of depletion effects in biological and other soft matter systems, it is desirable to have coarse-grained Molecular Dynamics (MD) simulation approaches appropriate for the study of complex systems. This paper examines the use of two common truncated Lennard-Jones (Weeks-Chandler-Andersen (WCA)) potentials to describe a pair of colloidal particles in a thermal bath of depletants. The shifted-WCA model is the steeper of the two repulsive potentials considered, while the combinatorial-WCA model is the softer. It is found that the depletion-induced well depth for the combinatorial-WCA model is significantly deeper than the shifted-WCA model because the resulting overlap ofmore » the colloids yields extra accessible volume for depletants. For both shifted- and combinatorial-WCA simulations, the second virial coefficients and pair potentials between colloids are demonstrated to be well approximated by the Morphometric Thermodynamics (MT) model. This agreement suggests that the presence of depletants can be accurately modelled in MD simulations by implicitly including them through simple, analytical MT forms for depletion-induced interactions. Although both WCA potentials are found to be effective generic coarse-grained simulation approaches for studying depletion effects in complicated soft matter systems, combinatorial-WCA is the more efficient approach as depletion effects are enhanced at lower depletant densities. The findings indicate that for soft matter systems that are better modelled by potentials with some compressibility, predictions from hard-sphere systems could greatly underestimate the magnitude of depletion effects at a given depletant density.« less

  18. Predictors of medical and mental health care use in patients with irritable bowel syndrome in the United States.

    PubMed

    Gudleski, Gregory D; Satchidanand, Nikhil; Dunlap, Laura J; Tahiliani, Varnita; Li, Xiaohua; Keefer, Laurie; Lackner, Jeffrey M

    2017-01-01

    Because health care demand among IBS patients imposes a heavy economic burden, identifying high utilizers has potential for improving quality and efficiency of care. Previous research has not identified reliable predictors of utilization of IBS patients. We sought to identify factors predictive of health care utilization among severe IBS patients. 291 IBS patients completed testing whose content mapped onto the Andersen model of health care utilization. 2-stage hurdle models were used to determine predictors of health care use (probability and frequency). Separate analyses were conducted for mental health and medical services. Whether patients used any medical care was predicted by diet and insurance status. Tobacco use, education, and health insurance predicted the probability of using mental health care. The frequency of medical care was associated with alcohol use and physical health status, while frequency of mental health services was associated with marital status, tobacco use, education, distress, stress, and control beliefs over IBS symptoms. For IBS patients, the demand for health care involves a complex decision-making process influenced by many factors. Particularly strong determinants include predisposing characteristics (e.g., dietary pattern, tobacco use) and enabling factors (e.g., insurance coverage) that impede or facilitate demand. Which factors impact use depends on whether the focus is on the decision to use care or how much care is used. Decisions to use medical and mental health care are not simply influenced by symptom-specific factors but by a variety of lifestyle (e.g., dietary pattern, education, smoking) and economic (e.g., insurance coverage) factors. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Factors Associated to Health Care Service Use among Latino Day Laborers

    PubMed Central

    Boyas, Javier Francisco; Negi, Nalini Junko; Valera, Pamela

    2017-01-01

    Latino day laborers (LDLs) are at elevated risks for disease and injury because of the environments in which they work. Despite this recognition, a comprehensive examination of factors related to LDLs’ health service use remains unexamined. Using the Andersen model, the current exploratory study examined predisposing (age, education level, location of educational training, legal status, and marital status), enabling (income, trust in medical personnel, whether the respondent has someone they consider their personal doctor, and whether their doctor speaks the same language, perceived barriers to care), and need (self-rated health, number of chronic conditions) variables to predict use of health services among a purposive sample of LDLs (N = 150). Cross-sectional data were collected in 2012 from 4 day laborer sites in Dallas and Arlington, Texas. Regression results suggest that the strongest predictor of health care use was trust in medical providers (β = .41). LDLs who were U.S legal residents (β = .21), reported multiple chronic conditions (β = .16), and had a doctor who spoke their language (β = .15) reported significantly higher levels of health care usage. In terms of barriers, not being able to pay for services (β = −.23), lacking health care insurance coverage (β = −.22), and being embarrassed or having a family member not approve of utilizing services (β = −.18) were significantly associated with lower health care usage among LDLs. These findings suggest that LDLs are faced with a number of predisposing, enabling, and need factors that comprise health care use. PMID:28625117

  20. Characterizing hydrophobicity of amino acid side chains in a protein environment via measuring contact angle of a water nanodroplet on planar peptide network.

    PubMed

    Zhu, Chongqin; Gao, Yurui; Li, Hui; Meng, Sheng; Li, Lei; Francisco, Joseph S; Zeng, Xiao Cheng

    2016-11-15

    Hydrophobicity of macroscopic planar surface is conventionally characterized by the contact angle of water droplets. However, this engineering measurement cannot be directly extended to surfaces of proteins, due to the nanometer scale of amino acids and inherent nonplanar structures. To measure the hydrophobicity of side chains of proteins quantitatively, numerous parameters were developed to characterize behavior of hydrophobic solvation. However, consistency among these parameters is not always apparent. Herein, we demonstrate an alternative way of characterizing hydrophobicity of amino acid side chains in a protein environment by constructing a monolayer of amino acids (i.e., artificial planar peptide network) according to the primary and the β-sheet secondary structures of protein so that the conventional engineering measurement of the contact angle of a water droplet can be brought to bear. Using molecular dynamics simulations, contact angles θ of a water nanodroplet on the planar peptide network, together with excess chemical potentials of purely repulsive methane-sized Weeks-Chandler-Andersen solute, are computed. All of the 20 types of amino acids and the corresponding planar peptide networks are studied. Expectedly, all of the planar peptide networks with nonpolar amino acids are hydrophobic due to θ [Formula: see text] 90°, whereas all of the planar peptide networks of the polar and charged amino acids are hydrophilic due to θ [Formula: see text] 90°. Planar peptide networks of the charged amino acids exhibit complete-wetting behavior due to θ [Formula: see text] 0°. This computational approach for characterization of hydrophobicity can be extended to artificial planar networks of other soft matter.

  1. "Where It Falls Apart": Barriers to Retention in HIV Care in Latino Immigrants and Migrants.

    PubMed

    Levison, Julie H; Bogart, Laura M; Khan, Iman F; Mejia, Dianna; Amaro, Hortensia; Alegría, Margarita; Safren, Steven

    2017-09-01

    Latino immigrants in the United States are disproportionately affected by HIV. Barriers to consistent attendance (retention) in HIV primary care constrain opportunities for HIV treatment success, but have not been specifically assessed in this population. We conducted semistructured interviews with 37 HIV-infected Latinos (aged ≥18 years and born in Puerto Rico or a Latin American Spanish-speaking country) and 14 HIV providers in metropolitan Boston (total n = 51). The Andersen Model of Healthcare Utilization informed a semistructured interview guide, which bilingual research staff used to explore barriers to HIV care. We used thematic analysis to explore the processes of retention in care. Six ubiquitous themes were perceived to influence HIV clinic attendance: (1) stigma as a barrier to HIV serostatus disclosure; (2) social support as a safety net during negative life circumstances; (3) unaddressed trauma and substance use leading to interruption in care; (4) a trusting relationship between patient and provider motivating HIV clinic attendance; (5) basic unmet needs competing with the perceived value of HIV care; and (6) religion providing a source of hope and optimism. Cultural subthemes were the centrality of family (familismo), masculinity (machismo), and trusting relationships (confianza). The timing of barriers was acute (e.g., eviction) and chronic (e.g., family conflict). These co-occurring and dynamic constellation of factors affected HIV primary care attendance over time. HIV-infected Latino immigrants and migrants experienced significant challenges that led to interruptions in HIV care. Anticipatory guidance to prepare for these setbacks may improve retention in HIV care in this population.

  2. Effective particle size from molecular dynamics simulations in fluids

    NASA Astrophysics Data System (ADS)

    Ju, Jianwei; Welch, Paul M.; Rasmussen, Kim Ø.; Redondo, Antonio; Vorobieff, Peter; Kober, Edward M.

    2017-12-01

    We report molecular dynamics simulations designed to investigate the effective size of colloidal particles suspended in a fluid in the vicinity of a rigid wall where all interactions are defined by smooth atomic potential functions. These simulations are used to assess how the behavior of this system at the atomistic length scale compares to continuum mechanics models. In order to determine the effective size of the particles, we calculate the solvent forces on spherical particles of different radii as a function of different positions near and overlapping with the atomistically defined wall and compare them to continuum models. This procedure also then determines the effective position of the wall. Our analysis is based solely on forces that the particles sense, ensuring self-consistency of the method. The simulations were carried out using both Weeks-Chandler-Andersen and modified Lennard-Jones (LJ) potentials to identify the different contributions of simple repulsion and van der Waals attractive forces. Upon correction for behavior arising the discreteness of the atomic system, the underlying continuum physics analysis appeared to be correct down to much less than the particle radius. For both particle types, the effective radius was found to be ˜ 0.75σ , where σ defines the length scale of the force interaction (the LJ diameter). The effective "hydrodynamic" radii determined by this means are distinct from commonly assumed values of 0.5σ and 1.0σ , but agree with a value developed from the atomistic analysis of the viscosity of such systems.

  3. Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins in the indoor environment.

    PubMed

    Brasel, T L; Martin, J M; Carriker, C G; Wilson, S C; Straus, D C

    2005-11-01

    The existence of airborne mycotoxins in mold-contaminated buildings has long been hypothesized to be a potential occupant health risk. However, little work has been done to demonstrate the presence of these compounds in such environments. The presence of airborne macrocyclic trichothecene mycotoxins in indoor environments with known Stachybotrys chartarum contamination was therefore investigated. In seven buildings, air was collected using a high-volume liquid impaction bioaerosol sampler (SpinCon PAS 450-10) under static or disturbed conditions. An additional building was sampled using an Andersen GPS-1 PUF sampler modified to separate and collect particulates smaller than conidia. Four control buildings (i.e., no detectable S. chartarum growth or history of water damage) and outdoor air were also tested. Samples were analyzed using a macrocyclic trichothecene-specific enzyme-linked immunosorbent assay (ELISA). ELISA specificity was tested using phosphate-buffered saline extracts of the fungal genera Aspergillus, Chaetomium, Cladosporium, Fusarium, Memnoniella, Penicillium, Rhizopus, and Trichoderma, five Stachybotrys strains, and the indoor air allergens Can f 1, Der p 1, and Fel d 1. For test buildings, the results showed that detectable toxin concentrations increased with the sampling time and short periods of air disturbance. Trichothecene values ranged from <10 to >1,300 pg/m3 of sampled air. The control environments demonstrated statistically significantly (P < 0.001) lower levels of airborne trichothecenes. ELISA specificity experiments demonstrated a high specificity for the trichothecene-producing strain of S. chartarum. Our data indicate that airborne macrocyclic trichothecenes can exist in Stachybotrys-contaminated buildings, and this should be taken into consideration in future indoor air quality investigations.

  4. Final integrated trip report: site visits to Area 50, Andersen Air Force Base, Guam National Wildlife Refuge, War in the Pacific National Historical Park, Guam, Rota and Saipan, CNMI, 2004-2005

    USGS Publications Warehouse

    Hess, Steven C.; Pratt, Linda W.

    2006-01-01

    Limestone forests are the most diverse natural plant communities of Guam. Like other natural vegetation types, these forests have a long history of anthropogenic disturbances, being altered and shaped by humans for more than 4,000 years. Although this occupation represents a relatively long human influence in comparison to other Pacific islands, animals associated with humans, such as commensal rodents, arrived in these islands beginning only 1,000 years ago, and larger mammals, such as pigs (Sus scrofa), may not have arrived until European contact. Limestone forests, which also occur on several other Mariana Islands, developed in the presence of frequent tropical storms and are therefore well adapted to this type of natural disturbance regime. However, recent human activities including large scale clearing and conversion combined with the presence of high levels of alien herbivores and seed predators, and the loss of ecological services provided by the former native avifauna may be causing the decline of Guam's forests. Limestone forests on northern Guam, much like those of other Mariana Islands, were heavily cleared for the construction of military installations during World War II. The accidental introduction of the Brown Tree Snake (Boiga irregularis; BTS) around this same period subsequently accelerated the disappearance of Guam's native avifauna and other endemic terrestrial vertebrates, and with them, seed dispersal, pollination, and the predatory regulation of herbivorous insects. Guam and the Mariana Islands contained a high proportion (32 pecent) of endemic bird species, with 4 forms endemic to Guam alone: the now extinct Guam Flycatcher (Myiagra freycineti), and Guam Bridled White-eye (Zosterops conspicillatpicillata), one of three island endemic subspecies from the Marianas; Guam rail (Rallus owstonii); and Guam Kingfisher (Todiramphus cinnamominus cinnamominus), an island endemic subspecies of the regionally endemic Micronesian Kingfisher. Guam once supported the Mariana Gallinule (Gallinula chloropus guami), the Mariana Mallard (Anas platyrhynchos oustaleti), Mariana Fruit-Dove (Ptilinopus roseicapilla), White-throated Ground Dove (Gallicolumba xanthonura xanthonura), Mariana Crow (Corvus kubaryi), and the Nightingale Reed-warbler (Acrocephalus luscinia), all endemic to the Mariana Islands. Other regionally endemic endangered species include the Micronesian Megapode (Megapodius laperouse), and the Mariana Swiftlet (Aerodramus bartschi), now reduced to a small population on Guam. Likewise, the flora of Guam is unique, with 21percent of its native vascular plants endemic to the Mariana Islands. In limestone forests of Northern Guam, a number of tall forest tree species such as joga, Elaeocarpus joga (Elaeocarpaceae); pengua or Macaranga thompsonii (Euphorbiaceae); ifit or Intsia bijuga (Fabaceae); seeded breadfruit or Artocarpus marianensis (Moraceae); and umumu or Pisonia grandis (Nyctaginaceae) may be in decline as a result of herbivory by mammals. All show reduced regeneration and age distributions highly skewed towards older individuals. These species provided important habitat for some of Guam's endangered forest birds that remain in captivity such as the Mariana Crow, Guam Kingfisher, and Guam Rail. The recent high frequency of intense tropical storms and herbivory caused by large populations of feral pigs and Philippine sambar deer (Cervus mariannus), as well as invasive alien vines that may suppress tree regeneration, could be permanently altering the structure of regenerating forests and composition of important canopy species on secondary limestone substrates that were cleared and compacted during airfield construction from 1944 through the 1970s. Guam National Wildlife Refuge (GNWR) was established at Ritidian Point, after it was determined to be excess property by the U.S. Navy. Most of the refuge, about 9,087 hectares, is an 'overlay refuge' on lands administered by the U.S. Air Force and U.S. Navy. Although the military mission comes first on these lands, the U.S. Fish and Wildlife Service assists in protecting native species and habitats. The recovery of limestone forest on Guam for forest bird habitat may require intensive management, including reduction of feral herbivores, propagation, out-planting, weed control, and periodic suppression of herbivorous insects. Research to support these techniques may be best accomplished in small areas where potential limiting factors can easily be experimentally manipulated. Area 50, a 24 ha enclosure, contains a relictual patch of relatively undisturbed limestone forest surrounded by tarmac allowing easy access and management opportunities to control alien mammals and snakes. These species have been periodically managed in the past, but recent typhoons have damaged snake-proofing on the enclosure fence. A new concrete barrier is planned to provide more permanent control opportunities within this enclosed area or another similar area, thereby allowing experimental research for various management regimes. Eradication and control of alien vertebrate and plant pests will provide habitat where native communities can be restored in a small, intensively managed area. The stated aim of this project is to "affect ecosystem restoration through the removal and exclusion of introduced species and the reestablishment and propagation of native species, with focus on the reintroduction of native forest bird species." This will be achieved by constructing a multispecies barrier surrounding the area, coordinated eradication of selected alien species within the area, and possible reintroduction of Mariana Crow, Guam Kingfisher, and Guam Rail. This barrier also allows experimental research questions to be addressed within the small enclosure around Area 50 that may be applied to manage and restore the larger areas of limestone forest on northern Guam and also similar forests on other islands of the Marianas.

  5. Influence of indoor microbial aerosol on the welfare of meat ducks.

    PubMed

    Yu, G L; Wei, L M; Liu, Y Y; Liu, J Y; Wang, Y; Gao, J; Chai, T J; Cai, Y M

    2016-01-01

    The aim of the study was to evaluate the effects of microbial aerosols on ducks' welfare and provide information on which to establish microbial aerosol concentration standards for poultry. A total of 1800 1-d-old Cherry Valley ducks were randomly divided into 5 groups (A, B, C, D and E) with 360 ducks in each. To obtain objective data, each group had three replications. Different microbial aerosol concentrations in different groups were created by controlling ventilation and bedding cleaning frequency. Group A was the control group and hygienic conditions deteriorated progressively from group B to E. A 6-stage Andersen impactor was used to detect the aerosol concentration of aerobes, fungi, gram-negative bacteria and an AGI-30 microbial air sampler detected endotoxins. Physiological stress was evaluated in the ducks by adrenocorticotropic hormone (ACTH) values in serum. To assess the effects of bioaerosol factors, welfare indicators including fluctuating asymmetry (FA), appearance and gait as well as the Lactobacillus caecal concentration were evaluated. The data showed group D had already reached the highest limit of concentration of airborne aerobic bacteria, airborne fungi, airborne gram-negative bacteria and airborne endotoxin. The ducks in this group had significantly increased serum ACTH values and significantly decreased caecal lactobacilli concentration. Furthermore, appearance and gait scores, wing length and overall FA and caecal Lactobacillus concentration in this group were significantly increased at 6 and 8 weeks of age. In conclusion, high concentrations of microbial aerosol adversely affected the welfare of meat ducks. The microbial aerosol values in group D suggest a preliminary upper limit concentration of bioaerosols in ambient air for healthy meat ducks.

  6. The Increasing Use of Theory in Social Gerontology: 1990–2004

    PubMed Central

    Putney, Norella M.; Rice, Melissa; Bengtson, Vern L.

    2010-01-01

    Objectives. To determine how often theory is used in published research in social gerontology, compare theory use over a 10-year period (1990–1994 to 2000–2004), and identify the theories most frequently used in social gerontology research. Methods. Systematic review of articles published in eight leading journals from 2000 to 2004 (N = 1,046) and comparison with a review conducted 10 years earlier. Results. Theory was mentioned in 39% of articles published from 2000 to 2004, representing a 12% increase in the use of theory over 10 years. This increase was driven by theories outside the core sociology of aging theories identified by Bengtson, V. L., Burgess, E. O., and Parrott, T. M. (1997). Theory, explanation, and a third generation of theoretical development in social gerontology. Journal of Gerontology: Social Sciences, 52B, S72–S88. The five most frequently used theories included the life course perspective, life-span developmental theories, role theory, exchange theory, and person–environment theory/ecological theories of aging. Commonly used models included stress process/stress and coping models, successful aging models, the Andersen behavioral model of health services use, models of control/self-efficacy/mastery, and disablement process models. Discussion. Theory use in social gerontology increased between 1990 and 2004, with a shift toward theories that cross disciplines. However, the majority of research in social gerontology continues to be atheoretical. Models are widely used as a supplement to or substitute for theory. Many of these models are currently being debated and elaborated, and over time, they may emerge as important theoretical contributions to social gerontology. PMID:20675614

  7. Social capital, outpatient care utilization and choice between different levels of health facilities in rural and urban areas of Bhutan.

    PubMed

    Herberholz, Chantal; Phuntsho, Sonam

    2018-06-18

    This study examines the factors that explain outpatient care utilization and the choice between different levels of health facilities in Bhutan, focusing on individual social capital, given Bhutan's geography of remote and sparsely populated areas. The more isolated the living, the more important individual social capital may become. Standard factors proposed by the Andersen model of healthcare utilization serve as control variables. Data for 2526 households from the 2012 Bhutan Living Standards Survey, which contains a social capital module covering structural, cognitive and output dimensions of social capital, are used. The results from the logistic regression analysis show that individual social capital is positively related with the probability of seeking treatment when ill or injured. Informal social contacts and perceived help and support are most important in rural areas, whereas specific trust matters in urban areas. The explanatory power of the model using a subset of the data for urban areas only, however, is very low as most predisposing and enabling factors are insignificant, which is not surprising though in view of better access to health facilities in urban areas and the fact that healthcare is provided free of charge in Bhutan. Multinomial regression results further show that structural and output dimensions of social capital influence the likelihood of seeking care at secondary or tertiary care facilities relative to primary care facilities. Moreover, economic status and place of residence are significantly associated with healthcare utilization and choice of health facility. The findings with respect to social capital suggest that strategizing and organizing social capital may help improve healthcare utilization in Bhutan. Copyright © 2018 Elsevier Ltd. All rights reserved.

  8. Generalized recursive solutions to Ornstein-Zernike integral equations

    NASA Astrophysics Data System (ADS)

    Rossky, Peter J.; Dale, William D. T.

    1980-09-01

    Recursive procedures for the solution of a class of integral equations based on the Ornstein-Zernike equation are developed; the hypernetted chain and Percus-Yevick equations are two special cases of the class considered. It is shown that certain variants of the new procedures developed here are formally equivalent to those recently developed by Dale and Friedman, if the new recursive expressions are initialized in the same way as theirs. However, the computational solution of the new equations is significantly more efficient. Further, the present analysis leads to the identification of various graphical quantities arising in the earlier study with more familiar quantities related to pair correlation functions. The analysis is greatly facilitated by the use of several identities relating simple chain sums whose graphical elements can be written as a sum of two or more parts. In particular, the use of these identities permits renormalization of the equivalent series solution to the integral equation to be directly incorporated into the recursive solution in a straightforward manner. Formulas appropriate to renormalization with respect to long and short range parts of the pair potential, as well as more general components of the direct correlation function, are obtained. To further illustrate the utility of this approach, we show that a simple generalization of the hypernetted chain closure relation for the direct correlation function leads directly to the reference hypernetted chain (RHNC) equation due to Lado. The form of the correlation function used in the exponential approximation of Andersen and Chandler is then seen to be equivalent to the first estimate obtained from a renormalized RHNC equation.

  9. Face Masks and Cough Etiquette Reduce the Cough Aerosol Concentration of Pseudomonas aeruginosa in People with Cystic Fibrosis.

    PubMed

    Wood, Michelle E; Stockwell, Rebecca E; Johnson, Graham R; Ramsay, Kay A; Sherrard, Laura J; Jabbour, Nassib; Ballard, Emma; O'Rourke, Peter; Kidd, Timothy J; Wainwright, Claire E; Knibbs, Luke D; Sly, Peter D; Morawska, Lidia; Bell, Scott C

    2018-02-01

    People with cystic fibrosis (CF) generate Pseudomonas aeruginosa in droplet nuclei during coughing. The use of surgical masks has been recommended in healthcare settings to minimize pathogen transmission between patients with CF. To determine if face masks and cough etiquette reduce viable P. aeruginosa aerosolized during coughing. Twenty-five adults with CF and chronic P. aeruginosa infection were recruited. Participants performed six talking and coughing maneuvers, with or without face masks (surgical and N95) and hand covering the mouth when coughing (cough etiquette) in an aerosol-sampling device. An Andersen Cascade Impactor was used to sample the aerosol at 2 meters from each participant. Quantitative sputum and aerosol bacterial cultures were performed, and participants rated the mask comfort levels during the cough maneuvers. During uncovered coughing (reference maneuver), 19 of 25 (76%) participants produced aerosols containing P. aeruginosa, with a positive correlation found between sputum P. aeruginosa concentration (measured as cfu/ml) and aerosol P. aeruginosa colony-forming units. There was a reduction in aerosol P. aeruginosa load during coughing with a surgical mask, coughing with an N95 mask, and cough etiquette compared with uncovered coughing (P < 0.001). A similar reduction in total colony-forming units was observed for both masks during coughing; yet, participants rated the surgical masks as more comfortable (P = 0.013). Cough etiquette provided approximately half the reduction of viable aerosols of the mask interventions during voluntary coughing. Talking was a low viable aerosol-producing activity. Face masks reduce cough-generated P. aeruginosa aerosols, with the surgical mask providing enhanced comfort. Cough etiquette was less effective at reducing viable aerosols.

  10. Live Imaging of Cell Motility and Actin Cytoskeleton of Individual Neurons and Neural Crest Cells in Zebrafish Embryos

    PubMed Central

    Andersen, Erica; Asuri, Namrata; Clay, Matthew; Halloran, Mary

    2010-01-01

    The zebrafish is an ideal model for imaging cell behaviors during development in vivo. Zebrafish embryos are externally fertilized and thus easily accessible at all stages of development. Moreover, their optical clarity allows high resolution imaging of cell and molecular dynamics in the natural environment of the intact embryo. We are using a live imaging approach to analyze cell behaviors during neural crest cell migration and the outgrowth and guidance of neuronal axons. Live imaging is particularly useful for understanding mechanisms that regulate cell motility processes. To visualize details of cell motility, such as protrusive activity and molecular dynamics, it is advantageous to label individual cells. In zebrafish, plasmid DNA injection yields a transient mosaic expression pattern and offers distinct benefits over other cell labeling methods. For example, transgenic lines often label entire cell populations and thus may obscure visualization of the fine protrusions (or changes in molecular distribution) in a single cell. In addition, injection of DNA at the one-cell stage is less invasive and more precise than dye injections at later stages. Here we describe a method for labeling individual developing neurons or neural crest cells and imaging their behavior in vivo. We inject plasmid DNA into 1-cell stage embryos, which results in mosaic transgene expression. The vectors contain cell-specific promoters that drive expression of a gene of interest in a subset of sensory neurons or neural crest cells. We provide examples of cells labeled with membrane targeted GFP or with a biosensor probe that allows visualization of F-actin in living cells1. Erica Andersen, Namrata Asuri, and Matthew Clay contributed equally to this work. PMID:20130524

  11. Factors affecting the use of prenatal care by non-western women in industrialized western countries: a systematic review.

    PubMed

    Boerleider, Agatha W; Wiegers, Therese A; Manniën, Judith; Francke, Anneke L; Devillé, Walter L J M

    2013-03-27

    Despite the potential of prenatal care for addressing many pregnancy complications and concurrent health problems, non-western women in industrialized western countries more often make inadequate use of prenatal care than women from the majority population do. This study aimed to give a systematic review of factors affecting non-western women's use of prenatal care (both medical care and prenatal classes) in industrialized western countries. Eleven databases (PubMed, Embase, PsycINFO, Cochrane, Sociological Abstracts, Web of Science, Women's Studies International, MIDIRS, CINAHL, Scopus and the NIVEL catalogue) were searched for relevant peer-reviewed articles from between 1995 and July 2012. Qualitative as well as quantitative studies were included. Quality was assessed using the Mixed Methods Appraisal Tool. Factors identified were classified as impeding or facilitating, and categorized according to a conceptual framework, an elaborated version of Andersen's healthcare utilization model. Sixteen articles provided relevant factors that were all categorized. A number of factors (migration, culture, position in host country, social network, expertise of the care provider and personal treatment and communication) were found to include both facilitating and impeding factors for non-western women's utilization of prenatal care. The category demographic, genetic and pregnancy characteristics and the category accessibility of care only included impeding factors.Lack of knowledge of the western healthcare system and poor language proficiency were the most frequently reported impeding factors. Provision of information and care in women's native languages was the most frequently reported facilitating factor. The factors found in this review provide specific indications for identifying non-western women who are at risk of not using prenatal care adequately and for developing interventions and appropriate policy aimed at improving their prenatal care utilization.

  12. Cancer survivorship and opioid prescribing rates: A population-based matched cohort study among individuals with and without a history of cancer.

    PubMed

    Sutradhar, Rinku; Lokku, Armend; Barbera, Lisa

    2017-11-01

    Little is known about opioid prescribing among individuals who have survived cancer. Our aim is to examine a predominantly socio-economically disadvantaged population for differences in opioid prescribing rates among cancer survivors compared with matched controls without a prior diagnosis of cancer. This was a retrospective population-wide matched cohort study. Starting in 2010, individuals residing in Ontario, Canada, who were 18 to 64 years of age and at least 5 years past their cancer diagnosis were matched to controls without a prior cancer diagnosis based on sex and calendar year of birth. Follow-up was terminated at any indication of cancer recurrence, second malignancy, or new cancer diagnosis. To examine the association between survivorship and the rate of opioid prescriptions, an Andersen-Gill recurrent event regression model was implemented, adjusting for numerous individual-level characteristics and also accounting for the matched design. The rate of opioid prescribing was 1.22 times higher among survivors than among their corresponding matched controls (adjusted relative rate, 1.22; 95% CI, 1.11-1.34). Individuals from lower income quintiles who were younger, were from rural neighborhoods, and had more comorbidities had significantly higher prescribing rates. Sex was not associated with prescribing rates. This increased rate of opioid prescribing was also seen among survivors who were 10 or more years past their cancer diagnosis (compared with their controls). This study demonstrates substantially higher opioid prescribing rates among cancer survivors, even long after attaining survivorship. This raises concerns about the diagnosis and management of chronic pain problems among survivors stemming from their cancer diagnosis or treatment. Cancer 2017;123:4286-4293. © 2017 American Cancer Society. © 2017 American Cancer Society.

  13. Racial-Ethnic Differences in Health Service Use in a Large Sample of Homeless Adults With Mental Illness From Five Canadian Cities.

    PubMed

    Stergiopoulos, Vicky; Gozdzik, Agnes; Nisenbaum, Rosane; Vasiliadis, Helen-Maria; Chambers, Catharine; McKenzie, Kwame; Misir, Vachan

    2016-09-01

    This study examined factors associated with health care use in an ethnically diverse Canadian sample of homeless adults with mental illness, a particularly disadvantaged group. Baseline survey data were available from five sites across Canada for 2,195 At Home/Chez Soi demonstration project participants. Negative binomial regression models examined the relationship between racial-ethnic or cultural group membership (white, N=1,085; Aboriginal, N=476; black, N=244; and other ethnoracial minority groups, N=390) and self-reported emergency department (ED) visits and hospitalizations in the past six months and past-month visits to a medical, other clinical, or social service provider. Adjusted models included other predisposing, enabling, and need factors, based on Andersen's behavioral model for vulnerable populations. Compared with white participants, black participants had a lower rate of ED visits (adjusted rate ratio [ARR]=.54, 95% confidence interval [CI]=.43-.69) and Aboriginal participants had a lower rate of medical visits (ARR=.84, CI=.71-.99) and a higher rate of visits to social service providers (ARR=1.54, CI=1.18-2.01). Participants in other ethnoracial minority groups had a higher rate of social service provider visits than white participants (ARR=1.44, CI=1.10-1.89). Access to a family physician, having at least high school education, and high needs for mental health services were associated with greater use of ED and medical visits and hospitalizations. Rates of ED and medical visits were lower with increased age and better physical health. In a system of universal health insurance that prioritizes access to and quality of care, the presence of racial-ethnic disparities experienced by this vulnerable population merits further attention.

  14. Nano-liposomal dry powder inhaler of tacrolimus: preparation, characterization, and pulmonary pharmacokinetics.

    PubMed

    Chougule, Mahavir; Padhi, Bijay; Misra, Ambikanandan

    2007-01-01

    The studies were undertaken to evaluate feasibility of pulmonary delivery of liposomaly encapsulated tacrolimus dry powder inhaler for prolonged drug retention in lungs as rescue therapy to prevent refractory rejection of lungs after transplantation. Tacrolimus encapsulated liposomes were prepared by thin film evaporation technique and liposomal dispersion was passed through high pressure homogenizer. Tacrolimus nano-liposomes (NLs) were separated by centrifugation and characterized. NLs were dispersed in phosphate buffer saline (PBS) pH 7.4 containing different additives like lactose, sucrose, and trehalose, and L-leucine as antiadherent. The dispersion was spray dried and spray dried powders were characterized. In vitro and in vivo pulmonary deposition was performed using Andersen Cascade Impactor and intratracheal instillation in rats respectively. NLs were found to have average size of 140 nm, 96% +/- 1.5% drug entrapment, and zeta potential of 1.107 mV. Trehalose based formulation was found to have low density, good flowability, particle size of 9.46 +/- 0.8 microm, maximum fine particle fraction (FPF) of 71.1 +/- 2.5%, mean mass aerodynamic diameter (MMAD) 2.2 +/- 0.1 microm, and geometric standard deviation (GSD) 1.7 +/- 0.2. Developed formulations were found to have in vitro prolonged drug release up to 18 hours, following Higuchi's Controlled Release model. In vivo studies revealed maximal residence of tacrolimus within lungs of 24 hours, suggesting slow clearance from the lungs. The investigation provides a practical approach for direct delivery of tacrolimus encapsulated in NLs for controlled and prolonged retention at the site of action. It may play a promising role as rescue therapy in reducing the risk of acute rejection and chronic rejection.

  15. The effects of excipients and particle engineering on the biophysical stability and aerosol performance of parathyroid hormone (1-34) prepared as a dry powder for inhalation.

    PubMed

    Shoyele, Sunday A; Sivadas, Neeraj; Cryan, Sally-Ann

    2011-03-01

    Pulmonary delivery of therapeutic peptides and proteins has many advantages including high relative bioavailability, rapid systemic absorption and onset of action and a non-invasive mode of administration which improves patient compliance. In this study, we investigated the effect of spray-drying (SD) and spray freeze-drying processes on the stability and aerosol performance of parathyroid hormone (PTH) (1-34) microparticles. In this study, the stabilisation effect of trehalose (a non-reducing sugar) and Brij 97 (a non-ionic surfactant) on spray-dried PTH particles was assessed using analytical techniques including circular dichroism (CD), fluorescence spectroscopy, modulated differential scanning calorimetry and an in vitro bioactivity assay. Physical characterisation also included electron microscopy, tap density measurement and laser light diffraction. The aerosol aerodynamic performance of the formulations was assessed using the Andersen cascade impactor. Based on these studies, a formulation for spray freeze-drying was selected and the effects of the two particle engineering techniques on the biophysical stability and aerosol performance of the resulting powders was determined. CD, fluorescence spectroscopy and bioactivity data suggest that trehalose when used alone as a stabilising excipient produces a superior stabilising effect than when used in combination with a non-ionic surfactant. This highlights the utility of CD and fluorescence spectroscopy studies for the prediction of protein bioactivity post-processing. Therefore, a method and formulation suitable for the preparation of PTH as a dry powder was developed based on spray-drying PTH with trehalose as a stabiliser with the bioactivity of SD PTH containing trehalose being equivalent to that of unprocessed PTH. © 2011 American Association of Pharmaceutical Scientists

  16. Antiretroviral drug diversion links social vulnerability to poor medication adherence in substance abusing populations.

    PubMed

    Tsuyuki, Kiyomi; Surratt, Hilary L

    2015-05-01

    Antiretroviral (ARV) medication diversion to the illicit market has been documented in South Florida, and linked to sub-optimal adherence in people living with HIV. ARV diversion reflects an unmet need for care in vulnerable populations that have difficulty engaging in consistent HIV care due to competing needs and co-morbidities. This study applies the Gelberg-Andersen behavioral model of health care utilization for vulnerable populations to understand how social vulnerability is linked to ARV diversion and adherence. Cross-sectional data were collected from a targeted sample of vulnerable people living with HIV in South Florida between 2010 and 2012 (n = 503). Structured interviews collected quantitative data on ARV diversion, access and utilization of care, and ARV adherence. Logistic regression was used to estimate the goodness-of-fit of additive models that test domain fit. Linear regression was used to estimate the effects of social vulnerability and ARV diversion on ARV adherence. The best fitting model to predict ARV diversion identifies having a low monthly income and unstable HIV care as salient enabling factors that promote ARV diversion. Importantly, health care need factors did not protect against ARV diversion, evidence that immediate competing needs are prioritized even in the face of poor health for this sample. We also find that ARV diversion provides a link between social vulnerability and sub-optimal ARV adherence, with ARV diversion and domains from the Behavioral Model explaining 25 % of the variation in ARV adherence. Our analyses reveal great need to improve engagement in HIV care for vulnerable populations by strengthening enabling factors (e.g. patient-provider relationship) to improve retention in HIV care and ARV adherence for vulnerable populations.

  17. Analysing recurrent hospitalizations in heart failure: a review of statistical methodology, with application to CHARM-Preserved.

    PubMed

    Rogers, Jennifer K; Pocock, Stuart J; McMurray, John J V; Granger, Christopher B; Michelson, Eric L; Östergren, Jan; Pfeffer, Marc A; Solomon, Scott D; Swedberg, Karl; Yusuf, Salim

    2014-01-01

    Heart failure is characterized by recurrent hospitalizations, but often only the first event is considered in clinical trial reports. In chronic diseases, such as heart failure, analysing all events gives a more complete picture of treatment benefit. We describe methods of analysing repeat hospitalizations, and illustrate their value in one major trial. The Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM)-Preserved study compared candesartan with placebo in 3023 patients with heart failure and preserved systolic function. The heart failure hospitalization rates were 12.5 and 8.9 per 100 patient-years in the placebo and candesartan groups, respectively. The repeat hospitalizations were analysed using the Andersen-Gill, Poisson, and negative binomial methods. Death was incorporated into analyses by treating it as an additional event. The win ratio method and a method that jointly models hospitalizations and mortality were also considered. Using repeat events gave larger treatment benefits than time to first event analysis. The negative binomial method for the composite of recurrent heart failure hospitalizations and cardiovascular death gave a rate ratio of 0.75 [95% confidence interval (CI) 0.62-0.91, P = 0.003], whereas the hazard ratio for time to first heart failure hospitalization or cardiovascular death was 0.86 (95% CI 0.74-1.00, P = 0.050). In patients with preserved EF, candesartan reduces the rate of admissions for worsening heart failure, to a greater extent than apparent from analysing only first hospitalizations. Recurrent events should be routinely incorporated into the analysis of future clinical trials in heart failure. © 2013 The Authors. European Journal of Heart Failure © 2013 European Society of Cardiology.

  18. A comparison of on-line and off-line bioaerosol measurements at a biowaste site.

    PubMed

    Feeney, Patrick; Rodríguez, Santiago Fernández; Molina, Rafael; McGillicuddy, Eoin; Hellebust, Stig; Quirke, Michael; Daly, Shane; O'Connor, David; Sodeau, John

    2018-06-01

    An air measurement campaign was carried out at a green-waste composting site in the South of Ireland during Spring 2016. The aim was to quantify and identify the levels of Primary Biological Aerosol Particles (PBAP) that were present using the traditional off-line, impaction/optical microscopy method alongside an on-line, spectroscopic approach termed WIBS (Wideband Integrated Bioaerosol Sensor), which can provide number concentrations, sizes and "shapes" of airborne PBAP in real-time by use of Light Induced Fluorescence (LIF). The results from the two techniques were compared in order to validate the use of the spectroscopic method for determining the releases of the wide-range of PBAP present there as a function of site activity and meteorological conditions. The seven-day monitoring period undertaken was much longer than any real-time studies that have been previously performed and allowed due comparison between weekday (working) activities at the site and weekend (closed) releases. The time-span also allowed relationships between site activities like turning, agitation or waste delivery and the WIBS data to be determined in a quantitative manner. This information cannot be obtained with the Andersen Sampling methods generally employed at green-waste management sites. Furthermore, few specific bioaerosol types other than Aspergillus fumigatus, are identified using the traditional protocols employed for site licensing purposes. Here though the co-location of WIBS with the impaction instrument made it possible to identify the real-time release behaviour of a specific plant pathogenic spore, Ustilago maydis, present after green-waste deliveries were made by a local distillery. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Electromyographic Comparison of Squats Using Constant or Variable Resistance.

    PubMed

    Andersen, Vidar; Steiro Fimland, Marius; Knutson Kolnes, Maria; Jensen, Susanne; Laume, Martine; Hole Saeterbakken, Atle

    2016-12-01

    Andersen, V, Fimland, MS, Kolnes, MK, Jensen, S, Laume, M and Saeterbakken, AH. Electromyographic comparison of squats using constant or variable resistance. J Strength Cond Res 30(12): 3456-3463, 2016-The aim of the study was to compare the electromyographic (EMG) activity of vastus lateralis, vastus medialis, rectus femoris, and biceps femoris when performing the squat with constant resistance or variable resistance with 2 or 4 elastic bands, respectively, contributing with a mean of 39 and 73% of the total loads. Nineteen resistance-trained women performed 6 repetition maximum using 3 different experimental conditions: free weights (FW), free weights + 2 elastic bands (FW + 2EB), and free weights + 4 elastic bands (FW + 4EB). During analyses, each repetition was divided into 6 phases: upper (more extended knee), middle, and lower phase of the descending and ascending movements. Increased activation in the upper parts of the movement was observed for both variable resistance conditions compared with constant resistance (9-51%, p < 0.001-0.050). Further, a dose-response effect of variable resistance was observed in the upper ascending movement, with 4 elastic bands increasing muscle activation more than 2 elastic bands (7-28%, p = 0.003-0.007). For the whole movement, a 12% higher activation of the biceps femoris was observed for FW + 4EB compared with FW (p = 0.005). There were no differences between the other conditions in any of the muscles (p = 0.077-1.000). In conclusion, performing the squat using free weights in combination with elastic bands seems to be preferable compared with free weights alone and more so with a high contribution from variable resistance to the total load.

  20. Roughness-controlled self-assembly of mannitol/LB agar microparticles by polymorphic transformation for pulmonary drug delivery.

    PubMed

    Zhang, Fengying; Ngoc, Nguyen Thi Quynh; Tay, Bao Hui; Mendyk, Aleksander; Shao, Yu-Hsuan; Lau, Raymond

    2015-01-05

    Novel roughness-controlled mannitol/LB Agar microparticles were synthesized by polymorphic transformation and self-assembly method using hexane as the polymorphic transformation reagent and spray-dried mannitol/LB Agar microparticles as the starting material. As-prepared microparticles were characterized by Fourier transform infrared spectra (FTIR), X-ray diffraction spectra (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), and Andersen Cascade Impactor (ACI). The XRD and DSC results indicate that after immersing spray-dried mannitol/LB Agar microparticles in hexane, β-mannitol was completely transformed to α-mannitol in 1 h, and all the δ-mannitol was transformed to α form after 14 days. SEM shows that during the transformation the nanobelts on the spray-dried mannitol/LB Agar microparticles become more dispersed and the contour of the individual nanobelts becomes more noticeable. Afterward, the nanobelts self-assemble to nanorods and result in rod-covered mannitol/LB Agar microparticles. FTIR indicates new hydrogen bonds were formed among mannitol, LB Agar, and hexane. SEM images coupled with image analysis software reveal that different surface morphology of the microparticles have different drug adhesion mechanisms. Comparison of ACI results and image analysis of SEM images shows that an increase in the particle surface roughness can increase the fine particle fractions (FPFs) using the rod-covered mannitol microparticles as drug carriers. Transformed microparticles show higher FPFs than commercially available lactose carriers. An FPF of 28.6 ± 2.4% was achieved by microparticles transformed from spray-dried microparticles using 2% mannitol(w/v)/LB Agar as feed solution. It is comparable to the highest FPF reported in the literature using lactose and spray-dried mannitol as carriers.