Science.gov

Sample records for mm auslegung und

  1. Quantitative Analyse und Visualisierung der Herzfunktionen

    NASA Astrophysics Data System (ADS)

    Sauer, Anne; Schwarz, Tobias; Engel, Nicole; Seitel, Mathias; Kenngott, Hannes; Mohrhardt, Carsten; Loßnitzer, Dirk; Giannitsis, Evangelos; Katus, Hugo A.; Meinzer, Hans-Peter

    Die computergestützte bildbasierte Analyse der Herzfunktionen ist mittlerweile Standard in der Kardiologie. Die verfügbaren Produkte erfordern meist ein hohes Maß an Benutzerinteraktion und somit einen erhöhten Zeitaufwand. In dieser Arbeit wird ein Ansatz vorgestellt, der dem Kardiologen eine größtenteils automatische Analyse der Herzfunktionen mittels MRT-Bilddaten ermöglicht und damit Zeitersparnis schafft. Hierbei werden alle relevanten herzphysiologsichen Parameter berechnet und mithilfe von Diagrammen und Graphen visualisiert. Diese Berechnungen werden evaluiert, indem die ermittelten Werte mit manuell vermessenen verglichen werden. Der hierbei berechnete mittlere Fehler liegt mit 2,85 mm für die Wanddicke und 1,61 mm für die Wanddickenzunahme immer noch im Bereich einer Pixelgrösse der verwendeten Bilder.

  2. Fische und Fischerzeugnisse

    NASA Astrophysics Data System (ADS)

    Oehlenschläger, Jörg

    Fische und Fischerzeugnisse lassen sich gemäß den "Leitsätzen für Fische, Krebs- und Weichtiere und Erzeugnisse daraus" des Deutschen Lebensmittelbuches einteilen. Tiefgefrorene Fische werden von den "Leitsätzen für tiefgefrorene Fische, Krebs- und Weichtiere und Erzeugnisse daraus" und Salate mit Fleisch von Fischen, Krebs- und/oder Weichtieren durch Abschnitt II.B. der "Leitsätze für Feinkostsalate" abgedeckt. Zu nennen sind: Frischfische, Getrocknete Fische, Räucherfische, Gesalzene Fische, Erzeugnisse aus gesalzenen Fischen, Anchosen, Marinaden, Bratfischwaren, Kochfischwaren, Fischerzeugnisse in Gelee, Pasteurisierte Fischerzeugnisse, Fischdauerkonserven, Erzeugnisse aus Surimi, Krebstiere und Krebstiererzeugnisse, Weichtiere und Weichtiererzeugnisse und tiefgekühlte Fischereierzeugnisse.

  3. Information und Kommunikation

    NASA Astrophysics Data System (ADS)

    Wesoly, Michael; Ohlhausen, Peter; Bucher, Michael; Hichert, Rolf; Korge, Gabriele; Schnabel, Ulrich; Gairola, Arun; Reichwald, Ralf; Habicht, Hagen; Möslein, Kathrin; Schwarz, Torsten; Schönsleben, Paul; Scherer, Eric; Schloske, Alexander; Adlbrecht, Gerald; Federhen, Jens

    Wissen ist mittlerweile unverzichtbar für den entscheidenden Vorsprung auf dem Markt. Unabhängig davon, ob sich das Wissen in Innovationen, neuen Produkten und Dienstleistungen oder in der Verbesserung interner Unternehmensprozesse manifestiert: Wissen ist Treiber von Innovation, Wissen bringt Schnelligkeit und Wissen ist die Voraussetzung für Problemlösungen [40]. Wissensmanagement ist daher der Schlüssel für Unternehmenserfolg und bezeichnet den "bewussten und systematischen Umgang mit der Ressource Wissen und den zielgerichteten Einsatz von Wissen in der Organisation“ [6]. In dieser umfassenden Sichtweise ist Wissensmanagement ein Begriff, der Konzepte, Strategien und Methoden umfasst.

  4. Ingenieurgeologie: Grundlagen und Anwendung

    NASA Astrophysics Data System (ADS)

    Genske, Dieter D.

    Geplünderter Planet? Die Ingenieurgeologie ist ein junges, interdisziplinäres Fachgebiet. Es befasst sich mit der Wechselwirkung zwischen Geosphäre und Mensch. Der Autor stellt Georisiken vor und diskutiert die Folgen menschlicher Eingriffe in die Natur. Er thematisiert aktuelle Herausforderungen und entwirft nachhaltige Lösungskonzepte für verschiedene Problembereiche: z.B. Naturgefahren wie Hangrutschungen und Bergfälle, die Ausbeute natürlicher Ressourcen, Bau- und Sanierungsvorhaben. Fallbeschreibungen und ausgearbeitete Beispiele vertiefen das Verständnis für diesen neuen, zukunftsweisenden Zweig der Wissenschaft.

  5. Lymph- und Immunsystem

    NASA Astrophysics Data System (ADS)

    Perry, Steven F.

    Alle Lebewesen müssen sich gegen Eindringlinge wehren. Ihre Abwehrmechanismen wirken auf verschiedenen Ebenen, von übergeordneten Feindvermeidungsstrategien und Putzverhalten bis hin zu molekularen Erkennungs- und Tötungsmechanismen. Da Eindringlinge über Kontaktflächen mit der Außenwelt, wie z.B. Körperoberfläche, Darmwand und Atmungsoberflächen, in den Organismus gelangen, sind an diesen Stellen immer primäre Abwehrmechanismen zu finden. Dazu zählen (1) Schleimabsonderung (Schleimhäute bei allen Schädeltieren, Fischkiemen, epidermale Schleimdrüsen (Fische, Amphibien)), (2) Stoffwechselgifte und antibakteriell wirkende Substanzen in der Haut (Fische, Amphibien) und im Speichel (Amnioten), (3) Flimmerepithelien zum Abtransport von Eindringlingen und (4) starke Keratinbildung in der mehrschichtigen Epidermis und schützende Strukturen wie Schuppen, Federn und Haare (Amnioten) (S. 20). Auch die starke Säurebildung im Magen kann als Schutz gegen Eindringlinge betrachtet werden.

  6. Zwergsatelliten und Sternriesen

    NASA Astrophysics Data System (ADS)

    Baade, Dietrich; Kuschnig, Rainer

    2017-03-01

    Leuchtkräftige Sterne sind schwierig: Fär Fotometrie mit großen Teleskopen sind sie zu hell, und ihre geringe Zahl macht konventionelle Lösungen unwirtschaftlich, besonders im Weltraum, wo die äußerste Präzision gegeben wäre. Mit einer Mini-Armada von Nanosatelliten haben Ingenieure und Astronomen aus Kanada, Österreich und Polen nun die Lösung gefunden - auch schon für viele wissenschaftliche Fragen.

  7. Neuausrichtung und Konsolidierung

    NASA Astrophysics Data System (ADS)

    Grohmann, Heinz

    Mit der Wahl von Wolfgang Wetzel zum Vorsitzenden der Deutschen Statistischen Gesellschaft im Jahre 1972 begann eine 32jährige Ära, in der die praktische und die theoretische Statistik in einem ausgewogenen Verhältnis gepflegt wurden. Ein regelmäßiger vierjähriger Wechsel im Vorsitz stärkte die Gemeinschaft und die praktische wie die wissenschaftliche Arbeit gleichermaßen. Die jährlichen Hauptversammlungen behandelten gesellschaftlich aktuelle wie zukunftsorientierte Themen, und die Ausschüsse sowie weitere Veranstaltungen gaben Gelegenheit zur Förderung und Pflege einer Vielzahl von Arbeitsgebieten der Statistik. Darüber wird nicht nur in diesem Kapitel, sondern auch in den Teilen II und III des Bandes berichtet.

  8. Tensoren und Felder

    NASA Astrophysics Data System (ADS)

    Dirschmid, Hans J.

    Das Lehrbuch soll Studierende mit Grundkenntnissen der Differential- und Integralrechnung in die klassische Feldtheorie mit modernen mathematischen Methoden einführen. Dementsprechend ist die Tensoranalysis das mathematische Thema, das Prinzip der Relativität das physikalische. Aus didaktischen Erwägungen gliedert sich der Text in zwei Teile. Um den Leser mit den Objekten vertraut zu machen, wird zunächst der affine und euklidische Raum zugrundegelegt, um verallgemeinernd zur Geometrie auf Mannigfaltigkeiten und Riemannschen Räumen überleiten zu können. Im Anschluß an die mathematische Theorie wird in die spezielle und allgemeine Relativitätstheorie eingeführt, wobei die Geometrie der Raum-Zeit, die Grundgesetze der Elektrodynamik und der Gravitation sowie Folgerungen zur Sprache kommen.

  9. Falten und fliegen: Papierflieger und ihre Physik

    NASA Astrophysics Data System (ADS)

    Gruber, Werner

    2004-09-01

    Mit Papierfliegern können wichtige Eigenschaften der Aerodynamik anschaulich vermittelt werden: ein Blatt Papier, ein paar Faltungen und schon kann man experimentieren. Allerdings sind beim Trimmen des Fliegers einige Punkte zu beachten. Besonders wichtig ist die Y-Stellung der Flügel, die ihm Flugstabilität verleiht. Ist der Flieger fertig, dann gilt es, die dem Modell am besten angepasste Wurftechnik herauszufinden. Dazu variiert man Wurfgeschwindigkeit und Abwurfwinkel. Den Boden kann ein Papierflieger auf vier prinzipiell verschiedenen Flugkurven erreichen: Optimal ist die Gerade, dann fliegt er am weitesten.

  10. Messung und Analyse

    NASA Astrophysics Data System (ADS)

    Bathelt, Hartmut; Scheinhardt, Michael; Sell, Hendrik; Sottek, Roland; Guidati, Sandro; Helfer, Martin

    Für die Beurteilung von Akustik und Fahrkomfort eines Fahrzeugs gilt in der Fahrzeugentwicklung immer noch der alte Grundsatz: "Der Kunde fährt nicht am Prüfstand, sondern auf der Straße“. Daher werden Gesamtbeurteilungen des Entwicklungsstandes und Konkurrenzvergleiche (Benchmarking) nach wie vor auf der Straße durchgeführt, meist auf ausgewählten Fahrbahnen am Prüfgelände oder im Rahmen der regelmäßigen Winter- und Sommererprobungen unter extremen Witterungsverhältnissen.

  11. Getreide, Brot und Feine Backwaren

    NASA Astrophysics Data System (ADS)

    von Grabowski, Hans-Uwe; Rolfe, Birgit

    Getreide und Getreideerzeugnisse sind ebenso wie Brot und Feine Backwaren nach dem Lebensmittel- und Futtermittel-Gesetzbuch (LFGB) [1] Lebensmittel im Sinne des Artikels 2 der VO (EG) Nr. 178/2002 (BasisVO) (s. auch Kap. 1.6/2.4.1/3.2). Gesetzlich festgelegte Begriffsbestimmungen gibt es für diese Lebensmittel nicht. Man muss sich daher allgemeiner Verkehrsauffassungen bedienen, wie sie von der Deutschen Lebensmittelbuch-Kommission in Form von Leitsätzen erarbeitet und veröffentlicht wurden [2]. Der Gesundheitsschutz und der Schutz des Verbrauchers vor Täuschung sind in der Basis-VO und dem LFGB geregelt.

  12. Instandhaltung und Normung

    NASA Astrophysics Data System (ADS)

    Rosenkranz-Wuttig, Angela

    Das DIN Deutsches Institut für Normung e.V. ist ein eingetragener Verein mit Sitz in Berlin. Das DIN erarbeitet gemeinsam mit den Experten der interessierten Kreise Normen und Standards als Dienstleistung für Wirtschaft, Staat und Gesellschaft. Die Kenntnis entsprechender Normen, Standards oder Regeln, sowie deren richtiger Einsatz, ist unter den heutigen Marktbedingungen für jedes Unternehmen ein nicht zu unterschätzender wirtschaftlicher Faktor. Normen schaffen Effizienz bei Produktionsabläufen und sorgen durch eine gleichbleibende sowie vergleichbare Produktqualität für Vertrauen bei den Endverbrauchern. Darüber hinaus stehen Normen unter rechtlichen Aspekten für mehr Sicherheit - Hersteller erreichen bei Anwendung und Einhaltung von Normen ein hohes Maß an rechtlicher Absicherung. Das DIN vertritt die deutschen Interessen in den europäischen und weltweiten Normungsorganisationen, siehe Abb. 1. Zuständig für die elektrotechnische Normung in Deutschland sowie als deutscher Repräsentant in den übernationalen Gremien ist die DKE Deutsche Kommission Elektrotechnik Elektronik Informationstechnik im DIN und VDE.

  13. Datenintegration und Deduplizierung

    NASA Astrophysics Data System (ADS)

    Bleiholder, Jens; Schmid, Joachim

    In Unternehmen liegen viele Daten heutzutage immer seltener vollständig an einem einzigen physikalischen Ort vor, sondern sind weltweit verteilt. Dies liegt zum einen an der immer besser gewordenen Infrastruktur, die eine solche Verteilung auf einfache Art und Weise ermöglicht, und zum anderen an der Tatsache, dass viele Unternehmen weltweit tätig sind. So fallen Daten weltweit an, werden aber jeweils lokal - vor Ort - gespeichert. Daher müssen oft mehrere Datenquellen genutzt werden, um einen aktuellen, vollständigen und genauen Überblick über die vorhandenen Daten zu gewinnen. Datenintegration hilft, indem sie Daten aus mehreren Quellen zusammenführt und einheitlich darstellt. Diese integrierten Daten können genutzt werden, um sich einen Überblick über das Unternehmen zu verschaffen, z.B. wenn Unternehmen fusionieren und nur noch eine Kundendatenbank bestehen bleiben soll, oder wenn zu einem Kunden die Daten aus den verschiedenen Fachabteilungen zusammengeführt werden sollen. Anhand eines solchen Beispiels, der Integration von Kundendaten zu Kfz- und Lebensversicherungen erläutern wir im Folgenden einzelne Techniken.

  14. Statistik in Naturwissenschaft und Technik

    NASA Astrophysics Data System (ADS)

    Wilrich, Peter-Theodor

    Mit dem Aufschwung von Naturwissenschaft und Technik zu Beginn des 19. Jahrhunderts entstand die mathematische Statistik, angeregt aus der Geodäsie (wie die Methode der kleinsten Quadrate) und der Anthropologie (wie die statistische Analyse mehrdimensionaler Beobachtungen und ihrer stochastischen Abhängigkeiten). Im Gegensatz zu den Wirtschafts- und Sozialwissenschaften, in denen Daten vorwiegend aus Beobachtungsstudien gewonnen werden, stehen in den Naturwissenschaften Experimente im Vordergrund. Daher gehört die statistische Versuchsplanung zu den insbesondere in Naturwissenschaft und Technik angewendeten statistischen Methoden, aber auch die Extremwertstatistik und Lebensdaueranalysen sowie die Methoden der räumlichen Statistik (insbesondere in der Umweltforschung). Im 20. Jahrhundert wurden Stichprobenpläne und Regelkarten (Kontrollkarten) zur Prozessregelung als Hilfsmittel der statistischen Qualitätssicherung entwickelt. Diese Methodenbündel, mit denen sich der Ausschuss Statistik in Naturwissenschaft und Technik immer wieder befasst, werden im Folgenden vorgestellt.

  15. Primeval galaxies in the sub-mm and mm

    NASA Technical Reports Server (NTRS)

    Bond, J. Richard; Myers, Steven T.

    1993-01-01

    Although the results of COBE's FIRAS experiment 1 constrain the deviation in energy from the CMB blackbody in the 500-5000 micron range to be delta E/E, sub cmb less than 0.005, primeval galaxies can still lead to a brilliant sub-mm sky of non-Gaussian sources that are detectable at 10 inch resolution from planned arrays such as SCUBA on the James Clerk Maxwell Telescope and, quite plausibly, at sub-arcsecond resolution in planned mm and sub-mm interferometers. Here, we apply our hierarchical peaks method to a CDM model to construct sub-mm and mm maps of bursting PG's appropriate for these instruments with minimum contours chosen to correspond to realistic observational parameters for them and which pass the FIRAS limits.

  16. Apollo 17 Index: 70 mm, 35 mm, and 16 mm Photographs

    NASA Technical Reports Server (NTRS)

    Wells, Ronald A. (Compiler)

    1974-01-01

    This index lists and provides supplemental data for all Apollo 17 70 mm, 35 mm, and 16 mm photographs. The 70 mm and 35 mm photographs are indexed in three ways: (1) all photographs are listed in numerical sequence according to NASA photograph number, (2) photographs exposed in lunar orbit are listed according to longitude in 10deg increments, and (3) all photographs exposed on the lunar surface are listed in chronological order. In indexing the 70 mm and 35 mm orbital photographs, individual frames were matched to imagery on the 1:2,750,000 scale Lunar Planning Charts (LOC). Each frame was outlined on the LOC base map, and the principal point determined. The latitude and longitude of each principal point, to the nearest 0.1 degree, is recorded in this index, If the principal point of a photograph is in space or its location obscured by shadow, an approximate longitude was recorded so that the photograph would not be excluded from the computer-generated listing by longitude. Each frame is described in terms of a named lunar surface feature within the boundaries of the frame or, if no named features are within the frame boundaries, a major nearby feature.

  17. Tipps und Tricks

    NASA Astrophysics Data System (ADS)

    Häger, Wolfgang; Bauermeister, Dirk

    Hier wollen wir einige uns nützlich erscheinende Hinweise zur Arbeit mit dem Inventor geben. Dabei geht es vor allem darum, das Arbeiten mit dem Inventor zu vereinfachen. Die Beispiele stellen eine unvollständige Aufzählung dar und sollen dazu anregen, nach alternativen Vorgehensweisen zu suchen (hier sei noch einmal ausdrücklich auf das Internet verwiesen).

  18. Arbeitsgestaltung und Mitarbeiterqualifizierung

    NASA Astrophysics Data System (ADS)

    Weiss-Oberdorfer, Werner; Hörner, Barbara; Holm, Ruth; Pirner, Evelin

    Die Wertkette gliedert ein Unternehmen in strategisch relevante Tätigkeiten, um dadurch Kostenverhalten sowie vorhandene und potenzielle Differenzierungsquellen zu verstehen. Wenn ein Unternehmen diese strategisch wichtigen Aktivitäten billiger oder besser als seine Konkurrenten erledigt, verschafft es sich einen Wettbewerbsvorteil." Michael Porter, 1985

  19. Herschel und die Zukunft der Fern-Infrarot-Astronomie

    NASA Astrophysics Data System (ADS)

    Linz, Hendrik

    2015-06-01

    Schon lange ist die beobachtende Astronomie den engen Grenzen des optisch Sichbaren entwachsen und hat fast alle Bereiche des elektromagnetischen Spektrums für sich dienstbar gemacht. Im sogenannten nahen und mittleren Infrarot (Wellenlängen zwischen 1-30 μm) sowie im Millimeter- und Radio-Regime (Wellenlängen zwischen 1 mm und 10 m) ist die Erdatmosphäre relativ gut durchlässig für elektromagnetische Signale oder hat zumindest eine Vielzahl von spektral begrenzten Transmissionsfenstern, die astronomische Beobachtungen zumindest von höheren Bergen aus möglich machen. Allerdings ist das sogenannte Ferne Infrarot (FIR, 30-300 μm Wellenlänge) von der Erde aus fast völlig unzugänglich für astronomische Beobachtungen. Selbst für die besten Beobachtungsplätze der Erde bleibt die atmosphärische Transmission durch die immense Wasserdampf- Absorption auf ein absolutes Minimum beschränkt. Jedoch erlaubt uns das FIR Zugang zu Informationen, die sehr nützlich sind für die astrophysikalische Forschung und komplementär zu anderen Wellenlängen-Bereichen.

  20. Wirkstoffe, Medikamente und Mathematische Bildverarbeitung

    NASA Astrophysics Data System (ADS)

    Bauer, Günter J.; Lorenz, Dirk A.; Maaß, Peter; Preckel, Hartwig; Trede, Dennis

    Die Entwicklung neuer Medikamente ist langwierig und teuer. Der erste Schritt ist hierbei die Suche nach neuen Wirkstoffkandidaten, die für die Behandlung bislang schwer therapierbarer Krankheiten geeignet sind. Hierfür stehen der Pharma- und Biotechnologieindustrie riesige Substanzbibliotheken zur Verfügung. In diesen Bibliotheken werden die unterschiedlichsten Substanzen gesammelt, die entweder synthetisch hergestellt oder aus Pilzen, Bakterienkulturen und anderen Lebewesen gewonnen werden können.

  1. Apollo 12 photography 70 mm, 16 mm, and 35 mm frame index

    NASA Technical Reports Server (NTRS)

    1970-01-01

    For each 70-mm frame, the index presents information on: (1) the focal length of the camera, (2) the photo scale at the principal point of the frame, (3) the selenographic coordinates at the principal point of the frame, (4) the percentage of forward overlap of the frame, (5) the sun angle (medium, low, high), (6) the quality of the photography, (7) the approximate tilt (minimum and maximum) of the camera, and (8) the direction of tilt. A brief description of each frame is also included. The index to the 16-mm sequence photography includes information concerning the approximate surface coverage of the photographic sequence and a brief description of the principal features shown. A column of remarks is included to indicate: (1) if the sequence is plotted on the photographic index map and (2) the quality of the photography. The pictures taken using the lunar surface closeup stereoscopic camera (35 mm) are also described in this same index format.

  2. Feasibility of a Sustainer Projectile in the 30-mm, 35-mm, and 40-mm Caliber Range

    DTIC Science & Technology

    1980-08-01

    calibers appropriate for air defense. Sustaining the muzzle velocity has the advantage of decreasing the projectile time of flight, thus reducing the...mm Rocket-Assisted Projectiles Air Defense 30 mm 20 A@SrACT I"Centfate an eerseod if VHW en Identify by blocek number) A sustainer projectile is a...feasibility of RAP’s in the smaller calibers appropriate for air defense, * .i.e., the 30-40 nn caliber range. The nominal objective of this study was to

  3. Zusammenfassung und Ausblick

    NASA Astrophysics Data System (ADS)

    Knopp, Lothar; Wiegleb, Gerhard

    Mit dem vorliegenden Buch wird als Ergebnis eines durch die Deutsche BundesstiftungUmwelt (DBU) geförderten Forschungsprojektes an der Brandenburgischen Technischen Universität Cottbus eine erste Standardisierung der Vorgehensweise zur Erfassung, Risikoabschätzung und Bewertung eines Biodiversitätsschadens nach dem Umweltschadensgesetz (USchadG) vorgelegt. Damit kann eine erste Bewertung potentieller Schadenssituationen vorgenommen werden. Die Nutzung der hier erarbeiteten Vorgehensweise bietet sich daher für all diejenigen an, die mit der Frage einer möglichen Haftung für Biodiversitätsschäden nach dem USchadG konfrontiert sind, seien es die Unteren und Oberen Naturschutzbehörden der Länder, die Schadensversicherer, die potentiell Haftenden oder die Naturschutzverbände.

  4. Pyropheophorbide und a as a catabolite of ethylene-induced chlorophyll und a degradation

    SciTech Connect

    Shimokawa, Keishi; Hashizume, Akihito ); Shioi, Yuzo )

    1990-05-01

    An enzyme extract prepared from ethylene-induced degreening Citrus fruits contains chlorophyll (Chl) degrading enzymes. The fate of Chl carbons during an enzymatic degradation was investigated using Chl {und a}-{sup 14}C. Accompanying the disappearance of labelled Chl {und a}, pheophorbide {und a} and pyropheophorbide {und a} appeared and accumulation of pyropheophorbide {und a} was observed. HydroxyChl {und a} was also detected, but this is thought to be an artifact during chromatography. Unlike ethylene-induced Citrus fruits (in vivo), further degradation of pyropheophorbide {und a} did not occur in vitro enzyme system. This suggests that there is a lack of enzyme(s) and/or cofactor(s) for further degradation. It is concluded that Chl {und a} degraded enzymatically by the following order: Chl {und a}, chlorophyllide {und a}, pheophorbide {und a} and pyropheophorbide {und a}.

  5. Organe der Osmoregulation und Exkretion

    NASA Astrophysics Data System (ADS)

    Møbjerg, Nadja

    Die meisten Schädeltiere sind in der Lage, die Wasser- und Ionenkonzentration ihres Innenmilieus zu regulieren, sind also im Hinblick auf ihren Ionenhaushalt weitgehend unabhängig von der Umgebung. Sie halten die Konzentration von Wasser und anorganischen Ionen in ihren Körperflüssigkeiten (interstitielle Flüssigkeit und Blut) innerhalb enger Grenzen konstant (Osmoregulierer). Schleim aale (Myxinoida) können zwar die Konzentration einzelner anorganischer Ionen regulieren, sind aber insgesamt der hohen Osmolarität des Meerwassers angepasst, also isoosmostisch zu diesem. Isoosmotisch oder leic ht hyperosmostisch zur Umgebung sind auch marine Neoselachier und Latimeria chalumnae (Actinistia), die dazu organische Osmolyte (Harnstoff und Trimethylaminoxid) im Blut akkumulieren (Osmokonformer). Bei anderen aquatischen Schädeltieren sind die Körperflüssigkeiten zur Umgebung hypoosmotisch (im Meerwasser) — sie halten Wasser zurück und scheiden anorganiche Ionen aus — oder hyperosmotisch (im Süßwasser), indem sie Wasser abgeben und anorganische Ionen aufnehmen.

  6. Beschallungstechnik, Beschallungsplanung und Simulation

    NASA Astrophysics Data System (ADS)

    Ahnert, Wolfgang; Goertz, Anselm

    Die primäre Aufgabe einer Lautsprecheranlage ist es, Musik, Sprache oder auch Signaltöne und Geräusche wiederzugeben. Diese können von einem Tonträger kommen (CD, Sprachspeicher), von einem anderen Ort übertragen (Zuspielung über Radio, TV, Telefon) oder vor Ort erzeugt werden. Letzteres umfasst Konzerte, Ansprachen, Durchsagen oder künstlerische Darbietungen, bei denen es meist darum geht, eine bereits vorhandene Quelle einer größeren oder weiter verteilten Anzahl von Personen zugänglich zu machen.

  7. Entwicklung und Formulierung der Unternehmensstrategie

    NASA Astrophysics Data System (ADS)

    Crespo, Isabel; Bergmann, Lars; Lacker, Thomas

    Ursprünglich stammt der Begriff "Strategie“ aus dem Altgriechischen: "strategos“ bedeutete "Heer“, "Heeresmacht“ und damit auch "konzentrierte Kraft“; das Wort "agein“ bedeutete "tun, machen, treiben“. Ein Stratege war also eine Person, die ein Heer führte und damit Kraft, Macht und Stärke konzentrierte und einsetzen konnte. Strategie bezeichnete dementsprechend die Maßnahmen, die in dieser Funktion entwickelt wurden. Daher ist es leicht verständlich, dass der Begriff Strategie bis in die Mitte des letzten Jahrhunderts in erster Linie militärisch verstanden wurde. Anschließend wurde der Begriff in weiteren Bereichen, wie beispielsweise der Unternehmensführung, verwendet. Im betriebswirtschaftlichen Sinne bedeutet der Begriff Strategie die langfristig geplante Verhaltensweise eines Unternehmens zur Erreichung seiner Ziele.

  8. Welt und Wirkungsprinzip (2nd Aufl.)

    NASA Astrophysics Data System (ADS)

    Landgraf, Werner

    2010-03-01

    Modell einer kausalen Bewirkung der Welt, und logische, geometrische, physikalische Interprätation dieser Kausalmenge und Fortwirkung der frühsten ihrer sukzessiv als echt Neues bewirkten und durch Vorhandenes oder Späteres nicht darstellbaren oder widerrufbaren Ereignisse als Dimensionen und sie verkörpernde primäre Naturkräfte, mit Korrespondenz zur beobachteten Welt und ihrer grundlegendsten Eigenschaften. Wirklich ist nur was wirkt, wo und wie. Entsprechend ist im Bogenelement statt der Eigenzeit die variante Anzahl Wirkungen relevant, 0 ≈ 1/h2 dS2 - 1/tpl2 (dt2 - 1/c2 {dq12 + G02/G2 [dq2,32 - ...]}) mit G0 = c4lpl/Epl ≈ G. Die heutigen Dimensionen und Naturkräfte entstanden in dieser Reihenfolge, haben 'komplementäre' aber gleichwertige statische und dynamische Aspekte, entsprechend ihren Termen in Bogenelement bzw. Vierervektor, aus derem Vergleich sowie mit denen ihrer Nachbarn folgen Grundgleichungen bzw. Erhaltungssätze. Jeweils individuelle Eigenschaften wie ihre Naturkonstante konkretisieren sie und tragen zu gattungsmäßigen wie globale Affinität und Äquivalenzen bei. Ältestes Gebiet oder räumlicher Rand jeder Dimension sind die ersten vom Vorgänger bewirkten Ereignisse, selbst raumzeitlicher Ursprung des Nachfolgers, dort einmalig und ewig maximal rotverschoben fortwirkend und nicht lokalisierbar, um neue Elementareinheiten verschieden und lichtartig mit deren Verhältnis oder dem ihrer globalen Zustandsgrößen als konstanten Anfangsimpuls, Expansion, Längen- oder Ereignisdichte zueinander. Der Übergang vom diskreten Modell weniger Informationen zum Kontinuum und die Korrespondenz zur Physik ist problemlos, Details wie ein kontinuierlicher, abrupter oder ganz fehlender Abfall der Metrik beim ältesten Gebiet sind aber nur durch Beobachtungen entscheidbar. Erörtert werden allgemeine und individuelle Eigenschaften und ihre Konsequenzen der Dimensionen mit ihren Kräften, selbst und im Verhältnis zueinander, etwa ihrer begrenzten

  9. Restaurierung von Seen und Renaturierung von Seeufern

    NASA Astrophysics Data System (ADS)

    Grüneberg, Björn; Ostendorp, Wolfgang; Leßmann, Dieter; Wauer, Gerlinde; Nixdorf, Brigitte

    Süßwasserseen haben als ökosysteme und Lebensraum für Pflanzen und Tiere eine herausragende Bedeutung für die Artenvielfalt auf der Erde und prägen als Landschaftselemente unsere natürliche Umwelt. Seen fungieren als natürliche Stoffsenken, vor allem für Kohlenstoff und Nährstoffe, aber auch als Senken für in ihren Einzugsgebieten emittierte gelöste und feste Schadstoffe. Darüber hinaus ist Wasser eine wichtige Naturressource. Süßwasserseen stellen in den meisten Regionen der Erde lebenswichtige Quellen für die Versorgung mit Trinkwasser und tierischem Eiweiß (Fischfang) dar. Sie dienen als Wasserspeicher für die landwirtschaftliche und industrielle Nutzung. Auch für Erholungsaktivitäten des Menschen kommt ihnen eine große Bedeutung zu.

  10. Bewegungsapparat: Postcraniales Skelett und Muskulatur

    NASA Astrophysics Data System (ADS)

    Fischer, Martin S.

    Der Bewegungsapparat bestimmt die Form des Wirbeltierkörpers. So lässt sich z. B. aus der Gestalt eines Fisches auf seine bevorzugt e Schwimmweise schließen (S. 61). Bei den aquatisch en Schädeltieren dominiert die Fortbewegung mit axialem Antrieb; bei den meisten Tetrapoda findet sich eine Kombination aus axialem Antrieb und Bewegung durch Gliedmaßen. Selbst beim höchst spezialisierten Gang, der bipeden Bewegung des Menschen, sind Torsionsbewegungen des Rumpfes noch maßgeblich und bestimmen auch die Grundform des menschlichen Körpers (z. B. die Taille). Obwohl die verschiedenen Antriebsmechanismen eine funktionelle Einheit bilden, werden im Folgenden das Axialskelett sowie der Schulter- und Beckengürtel mit den zugehörigen Extremitäten getrennt besprochen.

  11. Kosmologie und Teilchenphysik.

    NASA Astrophysics Data System (ADS)

    Appenzeller, I.

    This book is a selection of 17 articles published in the journal "Spektrum der Wissenschaft". The original English versions of the papers were first published in "Scientific American". Contents: 1. Einführung (I. Appenzeller). 2. Sehr große Strukturen im Universum (J. O. Burns). 3. Die großräumigen Eigenbewegungen der Galaxien (A. Dressler). 4. Dunkle Materie im Universum (L. M. Krauss). 5. Der doppelte Beta-Zerfall (M. K. Moe, S. P. Rosen). 6. Quark-Lepton Familien (D. B. Cline). 7. Beschleunigerexperimente testen kosmologische Theorien (D. N. Schramm, G. Steigman). 8. Das Rätsel der kosmologischen Konstanten (L. Abbott). 9. Das Higgs-Boson (M. J. G. Veltman). 10. Die Suche nach dem Protonenzerfall (J. M. LoSecco, F. Reines, D. Sinclair). 11. Das inflationäre Universum (A. H. Guth, P. J. Steinhardt). 12. Die fünfte Dimension (E. Schmutzer). 13. Die verborgenen Dimensionen der Raumzeit (D. Z. Freedman, P. van Nieuwenhuizen). 14. Ist die Natur supersymmetrisch? (H. E. Haber, G. L. Kane). 15. Schwerkraft und Antimaterie (T. Goldman, R. J. Hughes, M. M. Nieto). 16. Superstrings (M. B. Green). 17. Kosmische Strings (A. Vilenkin).

  12. 40 CFR Table 1 to Subpart Mm of... - General Provisions Applicability to Subpart MM

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Subpart MM 1 Table 1 to Subpart MM of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Combustion Sources at Kraft, Soda, Sulfite, and Stand-Alone Semichemical Pulp Mills Pt. 63, Subpt. MM, Table 1 Table 1 to Subpart MM of Part 63—General Provisions Applicability to Subpart MM General...

  13. 40 CFR Table 1 to Subpart Mm of... - General Provisions Applicability to Subpart MM

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Subpart MM 1 Table 1 to Subpart MM of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Combustion Sources at Kraft, Soda, Sulfite, and Stand-Alone Semichemical Pulp Mills Pt. 63, Subpt. MM, Table 1 Table 1 to Subpart MM of Part 63—General Provisions Applicability to Subpart MM General...

  14. Der Forschungsflughafen und das Institut fuer Luft- und Raumfahrtsysteme

    DTIC Science & Technology

    2007-11-02

    Broitzem: Deutsche Verkehrsfliegerschule Völkenrode: Deutsche Forschungsanstalt für Luftfahrt (DFL) Waggum: Technische Hochschule Grundsteinlegung...Forschungsflughafen Aerodata Deutsches Zentrum für Luft- und Raumfahrt DLR VW Air Services TU Braunschweig Luftfahrt -Bundesamt LBA Deutscher Aeroclub

  15. Lineare und verzweigte Blockcopolymere aus Polypeptiden und synthetischen Polymeren

    NASA Astrophysics Data System (ADS)

    Kukula, Hildegard

    2001-07-01

    Die vorliegende Arbeit beschäftigt sich mit der Synthese und den Eigenschaften von linearen und verzweigten amphiphilen Polypeptid-Blockcopolymeren. Die Frage nach dem Einfluss der Topologie und Konformation der Blockcopolymere auf die supramolekularen und kolloidalen Eigenschaften bildete einen wichtigen Aspekt bei den Untersuchungen. Die Blockcopolymere wurden nach einem mehrstufigen Reaktionsschema durch Kombination von anionischer und ringöffnender Polymerisation von Aminosäuren-N-Carboxyanhydriden (NCA) synthetisiert. Die Untersuchung der Polypeptid-Blockcopolymere hinsichtlich ihres Aggregationsverhaltens in fester Phase sowie in verdünnter wässriger Lösung erfolgte mittels Streumethoden (SAXS, WAXS, DLS) sowie abbildender Methoden (TEM). Durch Einsatz der Blockcopolymere als polymere Stabilisatoren in der Emulsionspolymerisation wurden Oberflächen funktionalisierte Latizes erhalten. Als Beispiel für eine pharmazeutische Anwendung wurden bioverträgliche Polypeptid-Blockcopolymere als Wirkstoff-Trägersysteme in der Krebstherapie eingesetzt. This work describes the synthesis and characterization of linear and branched polypeptide block copolymers having amphiphilic character. The studies focused on the impact of the block copolymers' conformation and architecture on the supramolecular and colloidal properties. The polypeptide block copolymers were prepared in a multi-step process involving the anionic synthesis of (poly)amino-functional polymers (polystyrene and polybutadiene) which where used as macroinitiators for the ring-opening polymerization of N-carboxyanhydrides (NCA) of protected a-aminoacids. Supramolecular structures of the block copolymers in the solid state as well as in diluted aqueous solution were investigated using scattering (SAXS, WAXS, DLS) and microscopic (TEM) methods. Both linear and branched polypeptide block copolymers were used as polymeric stabilizers in the emulsion polymerization of styrene to yield polypeptide

  16. Application of MM wave therapy in radiology

    SciTech Connect

    Avakian, R.S.; Gasparyan, L.V.

    1995-12-31

    The authors studied the effects of MM wave electromagnetic radiation influence on patients, affected by X-ray radiation during the reparation works after Chernobyl nuclear power plant exposure. They compared results of treatment of two groups of patients: (1) control group patients received only basis therapy; (2) testing group, 10 patients received basis therapy and MM wave influence. The authors used the wide band noise generator `Artsakh - 2` for local irradiation on the acupuncture points. Their data proved that low intensity MM waves have immunocorrective, antioxidant effects, and MM wave therapy is a perspective method for treatment of patients with radiological pathology.

  17. MM Algorithms for Some Discrete Multivariate Distributions.

    PubMed

    Zhou, Hua; Lange, Kenneth

    2010-09-01

    The MM (minorization-maximization) principle is a versatile tool for constructing optimization algorithms. Every EM algorithm is an MM algorithm but not vice versa. This article derives MM algorithms for maximum likelihood estimation with discrete multivariate distributions such as the Dirichlet-multinomial and Connor-Mosimann distributions, the Neerchal-Morel distribution, the negative-multinomial distribution, certain distributions on partitions, and zero-truncated and zero-inflated distributions. These MM algorithms increase the likelihood at each iteration and reliably converge to the maximum from well-chosen initial values. Because they involve no matrix inversion, the algorithms are especially pertinent to high-dimensional problems. To illustrate the performance of the MM algorithms, we compare them to Newton's method on data used to classify handwritten digits.

  18. Mittelwert- und Arbeitstaktsynchrone Simulation von Dieselmotoren

    NASA Astrophysics Data System (ADS)

    Zahn, Sebastian

    Getrieben durch die immer restriktiveren Anforderungen an das Emissions- und Verbrauchsverhalten moderner Verbrennungsmotoren steigt die Komplexität von Motormanagementsystemen mit jeder Modellgeneration an. Damit geht nicht nur eine Zunahme des Softwareumfangs von Steuergeräten sondern zugleich ein deutlicher Anstieg des Applikations-, Vermessungs- und Testaufwandes einher. Zur Effizienzsteigerung des Software- und Funktionsentwicklungsprozesses haben sich daher in der Automobilindustrie sowie in Forschungsinstituten verschiedene modell- und simulationsbasierte Methoden wie die Model-in-the-Loop (MiL) Simulation, die Software-in-the-Loop (SiL) Simulation, das Rapid Control Prototyping (RCP) sowie die Hardware-in-the-Loop (HiL) Simulation etabliert.

  19. Topika und deren Einsatz in der Dermatologie.

    PubMed

    Wohlrab, Johannes

    2016-11-01

    Grundkenntnisse zur Zusammensetzung und den regulatorischen Hintergründen von Topika gehören zu den alltäglich benötigten Herausforderungen dermatologisch-ärztlichen Handelns. Ein professioneller und indikationsgerechter Umgang bei der Auswahl, Verordnung und Anwendung topischer Präparate ist somit Voraussetzung für eine verantwortungsvolle fachärztliche Tätigkeit. Dabei bereiten die regulatorische Zuordnung (Arzneimittel, Medizinprodukt, Kosmetikum), die Feststellung der Erstattungsfähigkeit durch die GKV und die unzureichende Kennzeichnung des Vehikelsystems einzelner Präparate nicht selten Probleme. Bestreben sollte es sein, neben der Wahl des geeigneten Wirkstoffs und der geeigneten Konzentration ein an die Indikation der Therapie angepasstes galenisches System auszuwählen, um dessen Eigenwirkung für den therapeutischen Effekt nutzen zu können. Bei der Verschreibung von Rezepturarzneimitteln sollte nach Möglichkeit immer auf eine standardisierte Rezeptur (Magistralrezeptur) zurückgegriffen werden. Durch die Vielzahl der möglichen Inhaltsstoffe und der sich daraus ergebenden Komplexität eines galenischen Systems ist eine willkürliche Manipulation durch qualitative oder quantitative Veränderungen einzelner Komponenten mit hohen Risiken für eine Instabilität und damit für Sicherheit und Sinnhaftigkeit verbunden. Eine optimierte Anwendung von Topika setzt zudem Grundlagenkenntnisse zur Pharmakokinetik und zur evidenzbasierten Therapieplanung voraus.

  20. Multimedia contents production system (MM-CPS)

    NASA Astrophysics Data System (ADS)

    Roser, Miguel; Villegas, Paulo; Simon, Maria; Hernandez-Gil, J. F.; Aguado, Isidro

    1996-01-01

    A present characterized by deep worldwide changes, and a future where social relations and behaviors are going to undergo a substantial change need new telecommunications services in order to allow people to get closer, facilitate their daily tasks and place at their disposal multimedia information to be accessed anywhere and at any time. These new services are very dependent on the contents to be included in the applications. The purpose of this paper is to describe an universal MM contents production system (MM-CPS), which allows the generation of coded data files suitable to be included in MM-servers.

  1. MM Algorithms for Geometric and Signomial Programming.

    PubMed

    Lange, Kenneth; Zhou, Hua

    2014-02-01

    This paper derives new algorithms for signomial programming, a generalization of geometric programming. The algorithms are based on a generic principle for optimization called the MM algorithm. In this setting, one can apply the geometric-arithmetic mean inequality and a supporting hyperplane inequality to create a surrogate function with parameters separated. Thus, unconstrained signomial programming reduces to a sequence of one-dimensional minimization problems. Simple examples demonstrate that the MM algorithm derived can converge to a boundary point or to one point of a continuum of minimum points. Conditions under which the minimum point is unique or occurs in the interior of parameter space are proved for geometric programming. Convergence to an interior point occurs at a linear rate. Finally, the MM framework easily accommodates equality and inequality constraints of signomial type. For the most important special case, constrained quadratic programming, the MM algorithm involves very simple updates.

  2. QM/MM methods in inorganic chemistry.

    PubMed

    Bo, Carles; Maseras, Feliu

    2008-06-14

    Quantum mechanics/molecular mechanics (QM/MM) methods are a useful tool for the computational study of inorganic systems. They allow a quantitative description of systems larger than those treatable with pure QM methods, in principle with a comparable quality. QM/MM calculations are being currently applied to the research in a variety of topics, including structural effects of ligand bulk, selectivity in homogeneous catalysis and mechanical embedding in heterogeneous catalysis. The QM/MM approach is also useful for the separation of steric and electronic contributions, and as an auxiliary tool for geometry optimization when full QM methods are mandatory. The power of QM/MM methods in inorganic chemistry is illustrated in this Perspective with a summary of recent representative applications.

  3. Ruhende Flüssigkeiten und Gase

    NASA Astrophysics Data System (ADS)

    Heintze, Joachim

    Das mechanische Verhalten von Flüssigkeiten und Gasen ist dadurch gekennzeichnet, dass sie keine statische Schubfestigkeit besitzen, andernfalls würden sie nicht beginnen, zu fließen. In ruhenden Flüssigkeiten und Gasen können daher keine Schubspannungen bestehen:

  4. Physik gestern und heute Das Eiskalorimeter

    NASA Astrophysics Data System (ADS)

    Heering, P.

    2003-07-01

    Kalorimetrische Messungen gehören heute zum experimentellen Standardrepertoire im Bereich der Thermodynamik und der physikalischen Chemie. Das erste Gerät für derartige Messungen entwickelten Ende des 18. Jahrhunderts die französischen Wissenschaftler Antoine Laurent Lavoisier und Pierre Simon de Laplace.

  5. 29 mm Diameter Test Target Design Report

    SciTech Connect

    Woloshun, Keith Albert; Dale, Gregory E.; Olivas, Eric Richard; Naranjo, Angela Carol; Romero, Frank Patrick

    2016-08-15

    The Northstar target for Mo99 production is made up of Mo100 disks in a stack separated by coolant gaps for helium flow. A number of targets have been tested at ANL for both production of Mo99 and for thermal-hydraulic performance. These have all been with a 12 mm diameter target, even while the production goals have increased the diameter to now 29 mm. A 29 mm diameter target has been designed that is consistent with the ANL beam capabilities and the capabilities of the helium circulation system currently in use at ANL. This target is designed for 500 μA at 35 MeV electrons. While the plant design calls for 42 MeV, the chosen design point is more favorable and higher power given the limits of the ANL accelerator. The intended beam spot size is 12 mm FWHM, but the thermal analysis presented herein conservatively assumed a 10 mm FWHM beam, which results in a 44% higher beam current density at beam center.

  6. Laparoscopic cholecystectomy using 2-mm instruments.

    PubMed

    Uranüs, S; Peng, Z; Kronberger, L; Pfeifer, J; Salehi, B

    1998-10-01

    Today, laparoscopic cholecystectomy is the method of choice for treatment of symptomatic gallbladder disorders. It minimizes effects of the operation that are independent of the gallbladder, such as trauma to the abdominal wall and other soft tissue. The surgical wounds were even smaller when 2-mm trocars were used. Laparoscopic cholecystectomy using 2-mm instruments was performed in a consecutive series of 14 patients with symptomatic gallstones. The procedure was completed in 12 cases, with conversion to open surgery in two cases. Intraoperative cholangiography was always performed. The postoperative course was always uneventful. The cosmetic effect was highly satisfactory. The procedure using 2-mm instruments could be indicated in selected patients with uncomplicated gallstone disease.

  7. Littoral Combat Ship Mission Modules (LCS MM)

    DTIC Science & Technology

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-443 Littoral Combat Ship Mission Modules (LCS MM) As of FY 2017 President’s Budget Defense...Estimate RDT&E - Research, Development, Test, and Evaluation SAR - Selected Acquisition Report SCP - Service Cost Position TBD - To Be Determined TY

  8. Excalibur Precision 155mm Projectiles (Excalibur)

    DTIC Science & Technology

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-366 Excalibur Precision 155mm Projectiles (Excalibur) As of FY 2017 President’s Budget...Program Office Estimate RDT&E - Research, Development, Test, and Evaluation SAR - Selected Acquisition Report SCP - Service Cost Position TBD - To Be

  9. Optimizing digital 8mm drive performance

    NASA Technical Reports Server (NTRS)

    Schadegg, Gerry

    1993-01-01

    The experience of attaching over 350,000 digital 8mm drives to 85-plus system platforms has uncovered many factors which can reduce cartridge capacity or drive throughput, reduce reliability, affect cartridge archivability and actually shorten drive life. Some are unique to an installation. Others result from how the system is set up to talk to the drive. Many stem from how applications use the drive, the work load that's present, the kind of media used and, very important, the kind of cleaning program in place. Digital 8mm drives record data at densities that rival those of disk technology. Even with technology this advanced, they are extremely robust and, given proper usage, care and media, should reward the user with a long productive life. The 8mm drive will give its best performance using high-quality 'data grade' media. Even though it costs more, good 'data grade' media can sustain the reliability and rigorous needs of a data storage environment and, with proper care, give users an archival life of 30 years or more. Various factors, taken individually, may not necessarily produce performance or reliability problems. Taken in combination, their effects can compound, resulting in rapid reductions in a drive's serviceable life, cartridge capacity, or drive performance. The key to managing media is determining the importance one places upon their recorded data and, subsequently, setting media usage guidelines that can deliver data reliability. Various options one can implement to optimize digital 8mm drive performance are explored.

  10. Mm-wave power meter mount

    NASA Technical Reports Server (NTRS)

    Mullen, D. L.; Oltmans, D. A.; Stelzried, C. T.

    1968-01-01

    E-band thermistor mount and a technique for adjusting a temperature compensating thermistor to provide an electrically balanced bridge are used for measuring RF power in the mm-wavelength. The mount is relatively insensitive to temperature effects that cause measurement errors in single ended circuits.

  11. MM-122: High speed civil transport

    NASA Technical Reports Server (NTRS)

    Demarest, Bill; Anders, Kurt; Manchec, John; Yang, Eric; Overgaard, Dan; Kalkwarf, Mike

    1992-01-01

    The rapidly expanding Pacific Rim market along with other growing markets indicates that the future market potential for a high speed civil transport is great indeed. The MM-122 is the answer to the international market desire for a state of the art, long range, high speed civil transport. It will carry 250 passengers a distance of 5200 nm at over twice the speed of sound. The MM-122 is designed to incorporate the latest technologies in the areas of control systems, propulsions, aerodynamics, and materials. The MM-122 will accomplish these goals using the following design parameters. First, a double delta wing planform with highly swept canards and an appropriately area ruled fuselage will be incorporated to accomplish desired aerodynamic characteristics. Propulsion will be provided by four low bypass variable cycle turbofan engines. A quad-redundant fly-by-wire flight control system will be incorporated to provide appropriate static stability and level 1 handling qualities. Finally, the latest in conventional metallic and modern composite materials will be used to provide desired weight and performance characteristics. The MM-122 incorporates the latest in technology and cost minimization techniques to provide a viable solution to this future market potential.

  12. CCM3 to MM5 Data Conversion

    SciTech Connect

    Taylor, John; Mirin, Arthur

    2007-03-02

    The accompanying script (which uses the NCAR Command Language) ready output from the Community Climate Model Code, version 3 (CCM3) and converts it to input format for the Mesoscale Model, version 5 (MM5) code. The script utilizes a Fortran binary write routine.

  13. Dentalwerkstoffe und Dentalimplantate - Teil 2

    NASA Astrophysics Data System (ADS)

    Faltermeier, Andreas

    Wie in allen Bereichen der Medizin findet auch in der Zahnmedizin eine kontinuierliche Weiterentwicklung der verwendeten Werkstoffe statt. Gerade für Zahnersatz werden Werkstoffe gesucht, die zum einen ästhetisch, zum anderen haltbar und darüber hinaus auch körperverträglich sind. Auch steigt immer mehr der Wunsch der Patienten nach ästhetischen und zugleich biokompatiblen Materialien. Wurde früher fast ausschließlich als Füllungsmaterial im Seitenzahngebiet quecksilberhaltiges Amalgam verwendet, hat der Zahnarzt heutzutage eine große Auswahl an verschiedenen zahnfarbenen Materialien: zum einen werden sog. Komposite verwendet, das aus einer Polymermatrix mit eingebetteten Füllstoffen besteht, zum anderen können diverse Dentalkeramiken verwendet werden. Besonders die Verwendung von Hochleistungskeramiken, wie beispielsweise Zirkonoxid, das sich bereits als Bremsscheiben für Sportwägen, Hitzeschilde im Space Shuttle und als Kugelköpfe künstlicher Hüftgelenke bewährt hat, spielt heutzutage eine große Rolle bei der Verdrängung des Metalls aus der Mundhöhle. War es früher nur möglich, einen verloren gegangen Zahn mittels einer Brücke, die ein Beschleifen der Nachbarzähne zur Folge hat, oder durch herausnehmbaren Zahnersatz zu ersetzen, ist es heutzutage mit der modernen Implantologie möglich, Zahnersatz zahnschonend einzugliedern. Auch kann mittels Dentalimplantaten dem Wunsch vieler Patienten nach festem Zahnersatz anstelle eines herausnehmbaren Zahnersatzes entsprochen werden. So kann mit Hilfe neuer biokompatiblen Werkstoffe sowohl der ästhetische Anspruch befriedigt als auch das Selbstwertgefühl vieler Patienten angehoben werden.

  14. Aufbau und Anpassung der Motorsteuerungs-Software für Otto- und Dieselmotoren

    NASA Astrophysics Data System (ADS)

    Stuhler, Harald; Ricken, Volker; Diener, René

    Die Erfüllung steigender Kundenansprüche und strenger gesetzlicher Vorgaben hinsichtlich der Verringerung des Kraftstoffverbrauchs, der Reduzierung von Schadstoffemissionen, der Erhöhung von Fahrsicherheit, Fahrleistung und Fahrkomfort ist untrennbar mit dem Einzug elektronischer Systeme in moderne Kraftfahrzeuge verbunden. Die elektronischen Systeme bestimmen zunehmend den Kundennutzen und werden für die Differenzierung der Automobilhersteller untereinander immer wichtiger. Daher sind sie ein wesentlicher Erfolgsfaktor moderner Kraftfahrzeuge.

  15. Systemlieferant und OEM Hersteller für die Medizintechnik und Pharmabranche

    NASA Astrophysics Data System (ADS)

    Jakob, Thomas; Reichenberger, Robert

    Unter einem Original Equipment Manufacturer (OEM) versteht man einen Hersteller fertiger Komponenten oder Produkte, der diese in seinen eigenen Produktionsfabriken produziert, sie aber anschließend nicht selbst in den Handel bringt. Die Anforderungen an einen OEM für die Medizintechnik- und Pharmabranche sind weitaus komplexer und umfangreicher als in anderen Branchen. Diese zusätzlichen Anforderungen haben schließlich auch ihre Berechtigung, da es letztendlich immer um die Gesundheit und das Leben von Menschen geht. Ein OEM muss neben der heute immer stärker geforderten Flexibilität, Schnelligkeit und Wettbewerbsfähigkeit sämtliche für die Medizintechnik- und Pharmabranche erforderlichen Qualitäts- und Prozesssicherheitskriterien erfüllen. Entsprechende Nachweise sind durch regelmäßige Kunden- und Überwachungsaudits zu erbringen. Das Arbeitsumfeld eines OEM für die Medizintechnik- und Pharmabranche bezieht sich somit nicht nur auf die Herstellung der Produkte für seine Kunden, sondern auch auf die Einhaltung sämtlicher Normen, Sicherheitskriterien, regulatorischen Voraussetzungen und Gesetze die zur Herstellung der Produkte notwendig sind.

  16. PCR und Real-Time PCR

    NASA Astrophysics Data System (ADS)

    Konrad, Regina; Busch, Ulrich

    Die vielfältigen Anwendungsmöglichkeiten der Polymerasekettenreaktion (polymerase chain reaction, PCR) machen sie zu einer der wichtigsten und am häufigsten eingesetzten Methoden in der molekularbiologischen Forschung und Diagnostik. Für diese Technologie wurde der Erfinder der Methode, Kary Mullis, 1993 mit dem Nobelpreis ausgezeichnet. Die PCR erlaubt einen hochsensitiven und spezifischen in-vitro-Nachweis von Desoxyribonukleinsäuren (DNA), da im Zuge der Reaktion Sequenzabschnitte gezielt vermehrt werden. Innerhalb weniger Stunden können aus einem einzigen Zielmolekül 1012 identische Moleküle entstehen [1].

  17. Terahertz/mm wave imaging simulation software

    NASA Astrophysics Data System (ADS)

    Fetterman, M. R.; Dougherty, J.; Kiser, W. L., Jr.

    2006-10-01

    We have developed a mm wave/terahertz imaging simulation package from COTS graphic software and custom MATLAB code. In this scheme, a commercial ray-tracing package was used to simulate the emission and reflections of radiation from scenes incorporating highly realistic imagery. Accurate material properties were assigned to objects in the scenes, with values obtained from the literature, and from our own terahertz spectroscopy measurements. The images were then post-processed with custom Matlab code to include the blur introduced by the imaging system and noise levels arising from system electronics and detector noise. The Matlab code was also used to simulate the effect of fog, an important aspect for mm wave imaging systems. Several types of image scenes were evaluated, including bar targets, contrast detail targets, a person in a portal screening situation, and a sailboat on the open ocean. The images produced by this simulation are currently being used as guidance for a 94 GHz passive mm wave imaging system, but have broad applicability for frequencies extending into the terahertz region.

  18. Influence of thermal load on 450 mm Si-wafer IPD during lithographic patterning

    NASA Astrophysics Data System (ADS)

    Peschel, Thomas; Kalkowski, Gerhard; Eberhardt, Ramona

    2012-03-01

    We report on Finite Element Modeling (FEM) of the influence of heat load due to the lithographic exposure on the inplane distortion (IPD) of 450 mm Si-wafers and hence on the effect of the heat load on the achievable image placement accuracy. Based on a scenario of electron beam writing at an exposure power of 20 mW, the thermo-mechanical behavior of the chuck and the attached Si wafer is modeled and used to derive corresponding IPD values. To account for the pin structured chuck surface, an effective layer model is derived. Different materials for the wafer chuck are compared with respect to their influence on wafer IPD and thermal characteristics of the exposure process. Guidelines for the selection of the chuck material und suggestions for its cooling and corrective strategies on e-beam steering during exposure are derived.

  19. Hochschule fur Film und Fernsehen (Babelsberg).

    ERIC Educational Resources Information Center

    Neumann, Roland

    1992-01-01

    Describes the Hochschule fur Film und Fernsehen, an institution of higher education for the study of film and television production in Babelsberg, Germany (formerly the German Democratic Republic). Discusses the major reorientations in the school caused by Germany's reunification. (SR)

  20. Satellitenbewegung, band III: Natiirliche und gesteuerte bewegung.

    NASA Astrophysics Data System (ADS)

    Jochim, E. F.

    2014-12-01

    Im dritten Band der Satellitenbewegung werden in fortlaufender Nummerierung einige für Untersuchungen der Bewegung der künstlichen Satelliten wichtige Grundlagen der Astrodynamik mit ausführlichen mathematischen Formelsystemen behandelt. Dazu zählen die unterschiedlichen Aspekte der Bewegung der natürlichen Himmelskörper, die Steuerung und Kontrolle von künstlichen Objekten, und insbesondere die für eine Satellitenbahnanalyse wichtigen physikalischen Beeinflussungen einer Satellitenbewegung. Mathematisch entscheidend ist die Wahl geeigneter Bahnparameter, die ein bestimmtes Bewegungsproblem widerspruchsfrei und singularitätenfrei zu behandeln gestatten. Für die Behandlung routinemäßiger Aufgabenstellungen der Satellitenbewegung, in erster Linie einer präzisen Bahnbestimmung und Bahnverbesserung, kann auf eine Fülle von lehrbuchartigen Monographien verwiesen werden, so dass diese Problematik in der vorliegenden Arbeit nur angedeutet werden soll.

  1. Kosmische Katastrophen und der Ursprung der Religion.

    NASA Astrophysics Data System (ADS)

    Hoyle, F.

    This book is a German translation, by V. Delavre, from the English original "The origin of the Universe and the origin of religion", published in 1993. Contents: E. Sens: Die unterbrochene Musikstunde. Einleitung zur deutschen Ausgabe. C. Ryskamp: Einführung. R. N. Anshen: Vorwort. F. Hoyle: Kosmische Katastrophen und der Ursprung der Religion - Die Folgen der Respektabilität; Eiszeiten und Kometen; Die allgemeine Situation in den Nacheiszeiten; Kometen und der Ursprung der Religionen; Der Übergang zu Mittelalter und Neuzeit. Diskussionsbeiträge: Ruth Nanda Anshen, Freeman Dyson, Paul Oscar Kristeller, John Archibald Wheeler, James Schwartz, Roger Shinn, Milton Gatch, Philip Solomon, Norman Newell. F. Hoyle: Schlußwort. A. Tollmann: Nachwort zur deutschen Ausgabe.

  2. Uniform National Discharge Standards (UNDS): Outreach

    EPA Pesticide Factsheets

    Describes the Federalism and Tribal consultation efforts related to the Uniform National Discharge Standards (UNDS) and links to copies of each presentation, both to state and local representatives, as well as federally-recognized tribes.

  3. Positionsbestimmung des Unternehmens: Interne und externe Analyse

    NASA Astrophysics Data System (ADS)

    Bergmann, Lars; Crespo, Isabel; Portmann, Stefan

    Die Initiierung und Lenkung von Maßnahmen zur integrierten Modernisierung zielen auf die Verbesserung der Wettbewerbsfähigkeit eines Unternehmens ab. Damit diese Maßnahmen zielgerichtet die Wettbewerbsfähigkeit verbessern können, ist Wissen über die bestehende Wettbewerbsfähigkeit sowie über die bestehenden Fähigkeiten eine zentrale Voraussetzung. Eine zielgerichtete Auswahl problemadäquater Maßnahmen zur Verbesserung der Wettbewerbsfähigkeit bedarf daher im Vorfeld einer Bewertung der aktuellen Situation des Unternehmens im Sinne einer Positionsbestimmung. Erst wenn die internen Stärken und Schwächen sowie die externen Chancen und Risiken identifiziert sind, kann ein ganzheitliches Bild von der Position eines Unternehmens in seiner Umwelt gewonnen werden. Auf Basis der Kenntnisse über die Position des Unternehmens können anschließend zielgerichtet Maßnahmen ausgewählt werden, die einen Beitrag zur Verbesserung der Wettbewerbsfähigkeit des Unternehmens haben. Damit kommt der Positionsbestimmung als initialer Schritt des Prozesses der strategischen Unternehmensplanung eine zentrale Bedeutung im Rahmen der integrierten Modernisierung zu. Erfolgt die Auswahl von Maßnahmen ohne eine vorherige Positionsbestimmung, also lediglich auf Basis drängender Probleme, so besteht die Gefahr einer unbedachten und nur auf das "hier und heute“ bezogenen Schwerpunktbildung ohne Berücksichtigung der mittel- und langfristigen Ziele des Unternehmens.

  4. Prediction of Stereochemistry using Q2MM

    PubMed Central

    2016-01-01

    Conspectus The standard method of screening ligands for selectivity in asymmetric, transition metal-catalyzed reactions requires experimental testing of hundreds of ligands from ligand libraries. This “trial and error” process is costly in terms of time as well as resources and, in general, is scientifically and intellectually unsatisfying as it reveals little about the underlying mechanism behind the selectivity. The accurate computational prediction of stereoselectivity in enantioselective catalysis requires adequate conformational sampling of the selectivity-determining transition state but has to be fast enough to compete with experimental screening techniques to be useful for the synthetic chemist. Although electronic structure calculations are accurate and general, they are too slow to allow for sampling or fast screening of ligand libraries. The combined requirements can be fulfilled by using appropriately fitted transition state force fields (TSFFs) that represent the transition state as a minimum and allow fast conformational sampling using Monte Carlo. Quantum-guided molecular mechanics (Q2MM) is an automated force field parametrization method that generates accurate, reaction-specific TSFFs by fitting the functional form of an arbitrary force field using only electronic structure calculations by minimization of an objective function. A key feature that distinguishes the Q2MM method from many other automated parametrization procedures is the use of the Hessian matrix in addition to geometric parameters and relative energies. This alleviates the known problems of overfitting of TSFFs. After validation of the TSFF by comparison to electronic structure results for a test set and available experimental data, the stereoselectivity of a reaction can be calculated by summation over the Boltzman-averaged relative energies of the conformations leading to the different stereoisomers. The Q2MM method has been applied successfully to perform virtual ligand

  5. Apollo 15 Index of 70 mm Photographs

    NASA Technical Reports Server (NTRS)

    1972-01-01

    All Apollo 15 70 mm photographs to which NASA photo numbers have been assigned are described in this index. In the first section all photographs are listed in sequence by NASA photo numbers. In subsequent sections, lunar surface and lunar orbital photographs are cross-indexed. Lunar surface photographs are listed in chronological order within the following categories: SEVA and LM window photos (LM window photos were taken before, between, and after EVA's), EVA 1, EVA 2, and EVA 3. Photographs of the lunar surface taken while in lunar orbit are cross-indexed by longitude in 10 deg increments, starting with the easternmost (farside) photos, and progressing to the westernmost (nearside) photos. Within each 10 deg interval of longitude, photographs are listed sequentially by NASA photo number, not by specific longitude of the principal point of each photograph.

  6. Prediction of Stereochemistry using Q2MM.

    PubMed

    Hansen, Eric; Rosales, Anthony R; Tutkowski, Brandon; Norrby, Per-Ola; Wiest, Olaf

    2016-05-17

    The standard method of screening ligands for selectivity in asymmetric, transition metal-catalyzed reactions requires experimental testing of hundreds of ligands from ligand libraries. This "trial and error" process is costly in terms of time as well as resources and, in general, is scientifically and intellectually unsatisfying as it reveals little about the underlying mechanism behind the selectivity. The accurate computational prediction of stereoselectivity in enantioselective catalysis requires adequate conformational sampling of the selectivity-determining transition state but has to be fast enough to compete with experimental screening techniques to be useful for the synthetic chemist. Although electronic structure calculations are accurate and general, they are too slow to allow for sampling or fast screening of ligand libraries. The combined requirements can be fulfilled by using appropriately fitted transition state force fields (TSFFs) that represent the transition state as a minimum and allow fast conformational sampling using Monte Carlo. Quantum-guided molecular mechanics (Q2MM) is an automated force field parametrization method that generates accurate, reaction-specific TSFFs by fitting the functional form of an arbitrary force field using only electronic structure calculations by minimization of an objective function. A key feature that distinguishes the Q2MM method from many other automated parametrization procedures is the use of the Hessian matrix in addition to geometric parameters and relative energies. This alleviates the known problems of overfitting of TSFFs. After validation of the TSFF by comparison to electronic structure results for a test set and available experimental data, the stereoselectivity of a reaction can be calculated by summation over the Boltzman-averaged relative energies of the conformations leading to the different stereoisomers. The Q2MM method has been applied successfully to perform virtual ligand screens on a range of

  7. The Table Mountain 8-mm wavelength interferometer

    NASA Technical Reports Server (NTRS)

    Janssen, M. A.; Gary, B. L.; Gulkis, S.; Olsen, E. T.; Soltis, F. S.; Yamane, N. I.

    1979-01-01

    A two-element radio interferometer operating at 8.33-mm wavelength has been developed at the Jet Propulsion Laboratory's Table Mountain Observatory near Wrightwood, CA. The interferometer employs a 5.5-m and a 3-m diameter antenna on an east-west baseline of 60 or 120 m, yielding fringe spacings at transit of 28 or 14 arcsec, respectively. The broad intermediate-frequency bandpass of 100-350 MHz and the system noise temperature of 500 K provide high sensitivity for the measurement of continuum sources. The interferometer has been used for high-resolution studies of the planets and the sun, and it is currently being adapted to study solar flare emissions at high spatial and time resolution.

  8. Tycho Brahe - Instrumentenbauer und Meister der Beobachtungstechnik

    NASA Astrophysics Data System (ADS)

    Wolfschmidt, Gudrun

    Vor der Erfindung des Fernrohrs war der dänische Astronom Tycho Brahe (1546 - 1601) der bedeutendste beobachtende Astronom. Von seinem Observatorium Uraniborg auf der - damals dänischen - Insel Hven ist heute noch der Grundriß erkennbar, von Stjerneborg sind die Fundamente erhalten, die Kuppeln in den 1950er Jahren ergänzt. In der Astronomie-Ausstellung im Deutschen Museum gibt es ein Modell der Sternwarte Uraniborg und der zugehörigen Instrumente (Maßstab 1:10); das größere Modell wurde dem Technischen Museum in Malmö geschenkt. Die Instrumente, die er in den Observatorien Uraniborg und Stjerneborg benutzte, sind nicht erhalten. Aber es gibt gute Beschreibungen der Instrumente (Halbkreis, Quadranten, Sextanten, Armillarsphären, Triquetrum, Himmelsglobus) in seinem Buch Astronomiae instauratae mechanica (Wandsbek 1598). Eine Nachbildung des großen hölzernen Quadranten kann man im Runden Turm in Kopenhagen sehen. Zwei Sextanten, hergestellt für Tycho um 1600 von Jost Bürgi und Erasmus Habermel, gibt es noch im Nationalmuseum für Technik in Prag. Ähnlichkeiten von Tychos Instrumenten mit Groß-Instrumenten aus dem islamischen Kulturkreis sind auffällig. Tycho Brahes Meßgeräte markieren einen großen Fortschritt in der Entwicklung astronomischer Instrumente und Meßtechniken und bilden die Grundlage für den weiteren Fortschritt der Positionsastronomie und der damit verbundenen Tabellenwerke. Die Nachwirkungen sind bis ins 17. und 18. Jahrhundert nachweisbar.

  9. Low-Friction Minilaparoscopy Outperforms Regular 5-mm and 3-mm Instruments for Precise Tasks

    PubMed Central

    Firme, Wood A.; Lima, Diego L.; de Paula Lopes, Vladmir Goldstein; Montandon, Isabelle D.; Filho, Flavio Santos; Shadduck, Phillip P.

    2015-01-01

    Background and Objectives: Therapeutic laparoscopy was incorporated into surgical practice more than 25 y ago. Several modifications have since been developed to further minimize surgical trauma and improve results. Minilaparoscopy, performed with 2- to 3-mm instruments was introduced in the mid 1990s but failed to attain mainstream use, mostly because of the limitations of the early devices. Buoyed by a renewed interest, new generations of mini instruments are being developed with improved functionality and durability. This study is an objective evaluation of a new set of mini instruments with a novel low-friction design. Method: Twenty-two medical students and 22 surgical residents served as study participants. Three designs of laparoscopic instruments were evaluated: conventional 5 mm, traditional 3 mm, and low-friction 3 mm. The instruments were evaluated with a standard surgical simulator, emulating 4 exercises of various complexities, testing grasping, precise 2-handed movements, and suturing. The metric measured was time to task completion, with 5 replicates for every combination of instrument–exercise–participant. Results: For all 4 tasks, the instrument design that performed the best was the same in both the medical student and surgical resident groups. For the gross-grasping task, the 5-mm conventional instruments performed best, followed by the low-friction mini instruments. For the 3 more complex and precise tasks, the low-friction mini instruments outperformed both of the other instrument designs. Conclusion: In standard surgical simulator exercises, low-friction minilaparoscopic instruments outperformed both conventional 3- and 5-mm laparoscopic instruments for precise tasks. PMID:26390530

  10. Generation of Bessel Beams at mm- and Sub mm-wavelengths by Binary Optical Elements

    NASA Astrophysics Data System (ADS)

    Yu, Y. Z.; Dou, W. B.

    2008-07-01

    In this paper, binary optical elements (BOE’s) are designed for generating Bessel beams at mm- and sub mm- wavelengths. The design tool is to combine a genetic algorithm (GA) for global optimization with a two-dimension finite-difference time-domain (2-D FDTD) method for rigorous electromagnetic computation. The design process for converting a normally incident Gaussian beam into a Bessel beam is described in detail. Numerical results demonstrate that the designed BOE’s can not only successfully produce arbitrary order Bessel beams, but also have higher diffraction efficiencies when compared with amplitude holograms.

  11. Cold-electron bolometers for future mm and sub-mm sky surveys

    NASA Astrophysics Data System (ADS)

    Salatino, Maria; de Bernardis, Paolo; Mahashabde, Sumedh; Kuzmin, Leonid S.; Masi, Silvia

    2014-07-01

    Future sky surveys in the mm/sub-mm range, like the forthcoming balloon-borne missions LSPE, OLIMPO, SPIDER etc., will need detectors insensitive to cosmic rays (CRs) and with a NEP of the order of 10-17 ¥ 10-18 W/sqrt(Hz). The Cold-Electron Bolometers (CEBs) technology is promising, having the required proper- ties, since the absorber volume is extremely small and the electron system of the absorber is thermally insulated from the phonon system. We have developed an experimental setup to test the optical performance and the CRs insensitivity of CEBs, with the target of integrating them in the OLIMPO and LSPE focal planes.

  12. 40 CFR Table 1 to Subpart Mm of... - General Provisions Applicability to Subpart MM

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....860. 63.1(b)(2) Title V operating permit—see 40 CFR part 70 Yes All major affected sources are required to obtain a title V permit. 63.1(b)(3) Record of the applicability determination No All affected... applicability of each paragraph of subpart A of this part to sources subject to subpart MM. 63.1(c)(2) Title...

  13. 40 CFR Table 1 to Subpart Mm of... - General Provisions Applicability to Subpart MM

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....860. 63.1(b)(2) Title V operating permit—see 40 CFR part 70 Yes All major affected sources are required to obtain a title V permit. 63.1(b)(3) Record of the applicability determination No All affected... applicability of each paragraph of subpart A of this part to sources subject to subpart MM. 63.1(c)(2) Title...

  14. 40 CFR Table 1 to Subpart Mm of... - General Provisions Applicability to Subpart MM

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....860. 63.1(b)(2) Title V operating permit—see 40 CFR part 70 Yes All major affected sources are required to obtain a title V permit. 63.1(b)(3) Record of the applicability determination No All affected... applicability of each paragraph of subpart A of this part to sources subject to subpart MM. 63.1(c)(2) Title...

  15. MASTER: a radiometer for mm and sub-mm observations from the Antarctic Plateau

    NASA Astrophysics Data System (ADS)

    Boella, G.; Gervasi, M.; Passerini, A.; Sironi, G.; Tartari, A.; Zannoni, M.; Natale, V.

    A radiometer based on SIS mixers for astrophysical observations is being assembled. The system, cooled to cryogenic temperature by a pulse tube refrigerator, is intended for operation on the Antartic Plateau during the local winter, using the mm dishes available there in the future. The system prototype will be tested at the focus of the 2.6m MITO telescope at the Testa Grigia Observatory on the italian Alps. We discuss the system characteristics and the observational programs.

  16. System performance advances of 18-mm and 16-mm subminiature image intensifier sensors

    NASA Astrophysics Data System (ADS)

    Thomas, Nils I.

    2000-11-01

    Night vision system design has been centered aroudn the An/AVS-6 and AN/PVS-7 night vision goggle systems for the past 20 years. Goggle performance has improved during this time through increased performance of the image intensifier sensor, primarily the Omni IV sensor from ITT Industries Night Vision. Most of this improvement has been at the optimal light level (1E-3 fc scene illumination). Recent advances in image sensor performance from the filmless Generation (Gen) IV sensors has increased the low light level performance of night vision devices from 0.3 cy/mr to 0.7 cy/mr. In addition, sensor packaging design requirements have forced night vision sensor manufactures to design light weight, small volume sensors. ITT recently has designed such a sensor in a 16-mm format. This sensor if 50% lighter, up to 50% shorter, and has design features that simplify the objective lens design. New night vision goggles have been, and are being, designed which reduce the perceived head-supported weight. This paper presents signal-to-noise ratio, halo, and other film-less sensor data and similar 16-mm subminiature sensor data. The resulting system performance data will be described. Finally, the system design improvements and relationships with the subminiature 16-mm subminiature sensor will be given.

  17. MCT detectors: from IR to sub-mm and mm wavelength bands

    NASA Astrophysics Data System (ADS)

    Sizov, F. F.; Vasiliev, V. V.; Gumenjuk-Sichevska, J. V.; Kamenev, Yu. E.; Dvoretsky, S. A.; Mikhailov, N. N.

    2008-09-01

    Modern technology advances combined with unique physical properties of mercury cadmium telluride (MCT) material, empower low-signal applications in technical vision systems. Properties of MCT detectors manufactured from LPE and MBE epilayers and their dependences on thickness and doping both for IR and THz regions are discussed. It is shown by comparison of experimental data and modeling of I-V dark current characteristics that MCT photodiode ultimate electrical characteristics are limited by diffusion current in n+-n--p junctions and by current via the deep traps in the gap with position Et= 0.7 Eg above the valence band and concentrations Nt = (1.0-5.5)•1015 cm-3 which are comparable with donor concentration in n--region Nd = (1.1-1.8)•1015 cm-3. Detector array parameters for a wavelength range 8-12 microns are: detectivity D*=1.9•1011 cm•Hz1/2/W, noise equivalent difference temperature NEDT ~ 9 mK, dynamical resistance R ~ 4Â.109 Ohm for the reverse biases ΔV = 0.1-0.2 V. Also, it is shown that MCT layers can be successfully used as sub-mm or mm wave ambient temperature or moderately cooled hot electron bolometers. Thus, in addition to the wavelength range from SWIR to VLIR, where the MCT detectors are employed mainly as photodiodes or photoresistors, they can be used as sub-mm or mm wave detectors in the range from 190 microns to 8 mm. They can be employed here as semiconductor hot electron bolometers (SHEB). Measurements performed at electromagnetic wave frequencies ν = 37, 55, 77 GHz, and also at 0.89 and 1.58 THz with non-optimized Hg0.8Cd0.2Te bolometer prototype, has confirmed the basic concepts of SHEB. At ν = 0.89 THz, 77 GHz and 37 GHz the signal temperature dependencies were measured too. At 77 K the SHEB sensitivity at ν = 37 and 77 GHz is increasing up to two orders compared to room temperature data. The sensitivity Sν ~ 2 V/W at 300 K, and calculated both Johnson-Nyquist and generation-recombination noise values give estimations of

  18. 40 CFR Table Mm-1 to Subpart Mm of... - Default Factors for Petroleum Products and Natural Gas Liquids 1 2

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 21 2011-07-01 2011-07-01 false Default Factors for Petroleum Products... Suppliers of Petroleum Products Pt. 98, Subpt. MM, Table MM-1 Table MM-1 to Subpart MM of Part 98—Default Factors for Petroleum Products and Natural Gas Liquids 1 2 Products Column A: density(metric...

  19. 40 CFR Table Mm-1 to Subpart Mm of... - Default Factors for Petroleum Products and Natural Gas Liquids 1 2

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Default Factors for Petroleum Products... Suppliers of Petroleum Products Pt. 98, Subpt. MM, Table MM-1 Table MM-1 to Subpart MM of Part 98—Default Factors for Petroleum Products and Natural Gas Liquids 1 2 Products Column A: density(metric...

  20. 40 CFR Table Mm-1 to Subpart Mm of... - Default Factors for Petroleum Products and Natural Gas Liquids 1 2

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Default Factors for Petroleum Products... Suppliers of Petroleum Products Pt. 98, Subpt. MM, Table MM-1 Table MM-1 to Subpart MM of Part 98—Default Factors for Petroleum Products and Natural Gas Liquids 1 2 Products Column A: density(metric...

  1. 40 CFR Table Mm-1 to Subpart Mm of... - Default Factors for Petroleum Products and Natural Gas Liquids 1 2

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Default Factors for Petroleum Products... Suppliers of Petroleum Products Pt. 98, Subpt. MM, Table MM-1 Table MM-1 to Subpart MM of Part 98—Default Factors for Petroleum Products and Natural Gas Liquids 1 2 Products Column A: density(metric...

  2. The LLAMA 12 m mm/sub-mm radiotelescope in the Andes

    NASA Astrophysics Data System (ADS)

    Lepine, Jacques; Edemundo Arnal, Marcelo; de Graauw, Thijs; Abraham, Zulema; Gimenez de Castro, Guillermo; de Gouveia Dal Pino, Elisabete; Morras, Ricardo; Larrarte, Juan; Viramontes, José; Finger, Ricardo; Kooi, Jacob; Reeves, Rodrigo; Beaklini, Pedro

    2015-08-01

    LLAMA (Large Latin American Millimetric Array) is a joint Argentinean-Brazilian project of a 12m mm/sub-mm radio telescope similar to the APEX antenna, to be installed at a site at 4800 m altitude near San Antonio de Los Cobres in the Salta Province in Argentine, at 150 km from ALMA. The scientific cases for single dish and VLBI observations include black holes and accretion disks, the molecular evolution of interstellar clouds, the structure of the Galaxy, the formation of galaxies, and much more. The antenna was ordered to the company Vertex Antennentechnik in June 2014, and the construction is progressing quickly; it will be installed at the site in 2016. The radio telescope will be equipped with up to six receivers covering bands similar to those of ALMA. Cryostats with room for 3 cartridges, constructed by NAOJ (Tokyo,Japan), will be installed in each of the two Nasmyth cabins. Among the first receivers we will have an ALMA band 9 provided by NOVA (Groningen, Holland) and a band 5 from the Chalmers University (Sweden). Other receivers are still being discussed at the time of submission of this abstract,At high frequencies, VLBI observations at high frequencies could be made with ALMA, APEX and ASTE, and Northern radiotelescopes. In this way, LLAMA will be a seed for a Latin-American VLBI network.

  3. Teaching Evolutionary Mechanisms: Genetic Drift and M&M's.

    ERIC Educational Resources Information Center

    Staub, Nancy L.

    2002-01-01

    Describes a classroom activity that teaches the mechanism of genetic drift to undergraduates. Illustrates a number of concepts that are critical in developing evolution literacy by sampling M&M milk chocolate candies. (MM)

  4. Ökologische Grundlagen und limitierende Faktoren der Renaturierung

    NASA Astrophysics Data System (ADS)

    Hölzel, N.; Rebele, F.; Rosenthal, G.; Eichberg, C.

    In den dicht besiedelten und agrarisch besonders intensiv genutzten Regionen Mittel- und Westeuropas ist seit Ende des Zweiten Weltkrieges ein fortschreitender Verlust an naturnahen ökosystemen mit hoher biologischer Vielfalt zu verzeichnen. Spätestens seit den 1970er-Jahren ist daher die Neuschaffung und Wiederherstellung gefährdeter Lebensräume und Biozönosen zunehmend in den Mittelpunkt von Naturschutzmaßnahmen gerückt (Bakker 1989, Muller et al. 1998, Bakker und Berendse 1999). Aufgrund fehlender wissenschaftlicher Grundlagen und praktischer Erfahrungen wurden Renaturierungsmaßnahmen anfangs fast durchweg nach dem trial and error-Prinzip durchgeführt. Im Vordergrund standen dabei zunächst die Wiederherstellung adäquater abiotischer Standortbedingungen sowie die Reorganisation traditioneller Nutzungsmanagements. Bei Ersterem ging es neben der Wiedervernässung entwässerter Feuchtgebiete (Pfadenhauer und Grootjans 1999) vor allem darum, Eutrophierungseffekte zu beseitigen und die Produktivität des Standortes auf das Niveau der Zielgemeinschaft zurückzuführen (Gough und Marrs 1990, Oomes et al. 1996, Snow et al. 1997, Tallowin et al. 1998).

  5. Modellgestützte Hybrid Systementwicklung - Modellierung und Optimierung

    NASA Astrophysics Data System (ADS)

    Huber, Thomas

    Im Bereich der Hybridfahrzeugentwicklung wird nach wie vor intensiv an Konzepten zur Verbrauchseinsparung und Reduzierung von Emissionen gearbeitet. Gleichzeitig sollen "Fahrspaß" und Komfort solcher Fahrzeuge verbessert werden. Für verschiedene Anwendungen sind unterschiedlichste Hybridkonzepte denkbar und sinnvoll. Trotz dieser Variantenvielfalt und den daraus resultierenden technischen Anforderungen sind die Kosten eines Hybridfahrzeugs zu minimieren, wobei ein wesentlicher Aspekt bei der Kostenreduzierung die Stückzahl ist. Bei der Entwicklung von Komponenten steht daher, neben den technischen Anforderungen, deren vielseitige Einsetzbarkeit im Vordergrund.

  6. Sporadic Creutzfeldt-Jakob Disease MM1+2C and MM1 are Identical in Transmission Properties.

    PubMed

    Kobayashi, Atsushi; Matsuura, Yuichi; Iwaki, Toru; Iwasaki, Yasushi; Yoshida, Mari; Takahashi, Hitoshi; Murayama, Shigeo; Takao, Masaki; Kato, Shinsuke; Yamada, Masahito; Mohri, Shirou; Kitamoto, Tetsuyuki

    2016-01-01

    The genotype (methionine, M or valine, V) at polymorphic codon 129 of the PRNP gene and the type (1 or 2) of abnormal prion protein in the brain are the major determinants of the clinicopathological features of sporadic Creutzfeldt-Jakob disease (CJD), thus providing molecular basis for classification of sporadic CJD, that is, MM1, MM2, MV1, MV2, VV1 or VV2. In addition to these "pure" cases, "mixed" cases presenting mixed neuropathological and biochemical features have also been recognized. The most frequently observed mixed form is the co-occurrence of MM1 and MM2, namely MM1+2. However, it has remained elusive whether MM1+2 could be a causative origin of dura mater graft-associated CJD (dCJD), one of the largest subgroups of iatrogenic CJD. To test this possibility, we performed transmission experiments of MM1+2 prions and a systematic neuropathological examination of dCJD patients in the present study. The transmission properties of the MM1+2 prions were identical to those of MM1 prions because MM2 prions lacked transmissibility. In addition, the neuropathological characteristics of MM2 were totally absent in dCJD patients examined. These results suggest that MM1+2 can be a causative origin of dCJD and causes neuropathological phenotype similar to that of MM1.

  7. 40 CFR Table Mm-2 to Subpart Mm of... - Default Factors for Biomass-Based Fuels and Biomass

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 21 2011-07-01 2011-07-01 false Default Factors for Biomass-Based Fuels and Biomass MM Table MM-2 to Subpart MM of Part 98 Protection of Environment ENVIRONMENTAL... Biomass-Based Fuels and Biomass Biomass-based fuel and biomass Column A:Density (metric tons/bbl) Column...

  8. 40 CFR Table Mm-2 to Subpart Mm of... - Default Factors for Biomass-Based Fuels and Biomass

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Default Factors for Biomass-Based Fuels and Biomass MM Table MM-2 to Subpart MM of Part 98 Protection of Environment ENVIRONMENTAL... Biomass-Based Fuels and Biomass Biomass-based fuel and biomass Column A:Density (metric tons/bbl) Column...

  9. 40 CFR Table Mm-2 to Subpart Mm of... - Default Factors for Biomass-Based Fuels and Biomass

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Default Factors for Biomass-Based Fuels and Biomass MM Table MM-2 to Subpart MM of Part 98 Protection of Environment ENVIRONMENTAL... Biomass-Based Fuels and Biomass Biomass-based fuel and biomass Column A:Density (metric tons/bbl) Column...

  10. 40 CFR Table Mm-2 to Subpart Mm of... - Default Factors for Biomass-Based Fuels and Biomass

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Default Factors for Biomass-Based Fuels and Biomass MM Table MM-2 to Subpart MM of Part 98 Protection of Environment ENVIRONMENTAL... Biomass-Based Fuels and Biomass Biomass-based fuel and biomass Column A:Density (metric tons/bbl) Column...

  11. MM-Wave Cavity/Klystron Developments Using Deep X-Ray Lithography at the Advanced Photon Source

    SciTech Connect

    Song, J.J.; Kang, Y.W.; Kustom, R.L.; Mancini, D.C.; Nassiri, A.; Lai, B.; Jongwaard, E.N.; Caryotakis, G.; Feinerman, A.D.; White, V.; /Wisconsin U., Madison

    2006-10-25

    Recent microfabrication technologies based on LIGA (German acronym for Lithographe, Galvanoformung, und Abformung) have been applied to build high-aspect-ratio, metallic or dielectric, planar structures suitable for high-frequency rf cavity structures. The cavity structures would be used as parts of linear accelerators, microwave undulators, and mm-wave amplifiers. The microfabrication process includes manufacturing of precision x-ray masks, exposure of positive resist by x-rays through the mask, resist development, and electroforming of the final microstructure. Prototypes of a 32-cell, 108-GHz constant impedance cavity and a 66-cell, 94-GHz constant-gradient cavity were fabricated using the synchrotron radiation sources at APS. Preliminary design parameters for a 91-GHz modulator klystron along with an overview of the new technology are discussed.

  12. Darwin, Engels und die Rolle der Arbeit in der biologischen und kulturellen Evolution des Menschen

    NASA Astrophysics Data System (ADS)

    Reichholf, Josef H.

    Im Jahre 1876, 5 Jahre nach Erscheinen von Darwins Buch über die Evolution des Menschen und die sexuelle Selektion (Darwin 1871), veröffentlichte Friedrich Engels den berühmt gewordenen Essay "Anteil der Arbeit an der Menschwerdung des Affen“ (Engels 1876). Die Kernfrage darin lautet in Kurzform: Warum hat der Mensch eigentlich ein Bedürfnis nach Arbeit? Engels Antwort wird nachfolgend näher betrachtet und vom gegenwärtigen Kenntnisstand aus beurteilt. Wie sich zeigen wird, beantworten seine Überlegungen die Frage nicht wirklich. Sie ist weiterhin offen. Es können lediglich einige zusätzliche Anhaltspunkte zur Diskussion gestellt werden. Angesichts des drängenden Problems millionenfacher Arbeitslosigkeit und der Forderungen nach einem "Grundrecht auf Arbeit“ kommt den Überlegungen zum möglichen Ursprung des Bedürfnisses nach Arbeit mehr als nur akademisches Interesse zu.

  13. Implantate und Verfahren in der Augenheilkunde

    NASA Astrophysics Data System (ADS)

    Neuhann, Tobias H.

    Das in der Medizin mit am häufigsten verwendete Implantat weltweit ist die Intraokulare Linse (IOL). Die Gründe hierfür sind vielschichtig: einmal haben die Operationstechniken in den letzten 30 Jahren eine wesentliche Steigerung an Gleichmäßigkeit, Erfolg und Effizienz erfahren, zum anderen verursachen die gestiegenen Anforderungen des Alltags in den Industrienationen und im Berufsleben den höheren Anspruch an das Sehvermögen. Ist die menschliche Linse Ursache für schlechtes Sehvermögen, besteht meist eine Trübung des Linsenproteins. Diese Trübung nennt wird Volksmund Grauer Star genannt, wissenschaftlich die Katarakt (cataracta). Es gibt unterschiedliche Formen wie angeborene (congenita) oder erworbene, traumatische, krankheitsoder altersbedingte Formen [45]. Wird die eingetrübte Linse nun mittels moderner Operationsverfahren entfernt, muss für Ersatz dieses lichtbrechenden Mediums gesorgt werden [2].

  14. Haptische Modellierung und Deformation einer Kugelzelle

    NASA Astrophysics Data System (ADS)

    Schippritt, Darius; Wiemann, Martin; Lipinski, Hans-Gerd

    Haptische Simulationsmodelle dienen in der Medizin in erster Linie dem Training operativer Eingriffe. Sie basieren zumeist auf physikalischen Gewebemodellen, welche eine sehr genaue Simulation der biomechanischen Eigenschaften des betreffenden Gewebes erlauben, aber gleichzeitig sehr rechenintensiv und damit zeitaufwändig in der Ausführung sind. Die menschliche Wahrnehmung kann allerdings auch eine ungenaue haptische Modellierung psychooptisch ausgleichen. Daher kann es sinnvoll sein, haptische Simulationen auch mit nicht vollständig physikalisch definierten Deformationsmodellen durchzuführen. Am Beispiel der haptischer Simulation einer in-vitro Fertilisation wird gezeigt, dass durch die Anwendung eines geometrischen Deformationsmodells eine künstliche Befruchtung unter realistischen experimentellen Bedingungen in Echtzeit haptisch simuliert und damit trainiert werden kann.

  15. A λ 3 mm and 1 mm line survey toward the yellow hypergiant IRC +10420⋆

    PubMed Central

    Quintana-Lacaci, G.; Agúndez, M.; Cernicharo, J.; Bujarrabal, V.; Sánchez Contreras, C.; Castro-Carrizo, A.; Alcolea, J.

    2016-01-01

    Aims Our knowledge of the chemical properties of the circumstellar ejecta of the most massive evolved stars is particularly poor. We aim to study the chemical characteristics of the prototypical yellow hypergiant star, IRC +10420. For this purpose, we obtained full line surveys at 1 and 3 mm atmospheric windows. Methods We have identified 106 molecular emission lines from 22 molecular species. Approximately half of the molecules detected are N-bearing species, in particular HCN, HNC, CN, NO, NS, PN, and N2H+. We used rotational diagrams to derive the density and rotational temperature of the different molecular species detected. We introduced an iterative method that allows us to take moderate line opacities into account. Results We have found that IRC +10420 presents high abundances of the N-bearing molecules compared with O-rich evolved stars. This result supports the presence of a N-rich chemistry, expected for massive stars. Our analysis also suggests a decrease of the 12C/13C ratio from ≳ 7 to ~ 3.7 in the last 3800 years, which can be directly related to the nitrogen enrichment observed. In addition, we found that SiO emission presents a significant intensity decrease for high-J lines when compared with older observations. Radiative transfer modeling shows that this variation can be explained by a decrease in the infrared (IR) flux of the dust. The origin of this decrease might be an expansion of the dust shell or a lower stellar temperature due to the pulsation of the star. PMID:27458319

  16. Herstellung von Chitosan und einige Anwendungen

    NASA Astrophysics Data System (ADS)

    Struszczyk, Marcin Henryk

    2001-05-01

    1. Die Deacetylierung von crabshell - Chitosan führte gleichzeitig zu einem drastischen Abfall der mittleren viscosimetrischen Molmasse ( Mv), insbesondere wenn die Temperatur und die Konzentration an NaOH erhöht werden. Diese Parameter beeinflussten jedoch nicht den Grad der Deacetylierung (DD). Wichtig ist jedoch die Quelle des Ausgangsmaterials: Chitin aus Pandalus borealis ist ein guter Rohstoff für die Herstellung von Chitosan mit niedrigem DD und gleichzeitig hoher mittlerer Mv, während Krill-Chitin (Euphausia superba) ein gutes Ausgangsmaterial zur Herstellung von Chitosan mit hohem DD und niedrigem Mv ist. Chitosan, das aus Insekten (Calliphora erythrocephala), unter milden Bedingungen (Temperatur: 100°C, NaOH-Konzentration: 40 %, Zeit: 1-2h ) hergestellt wurde, hatte die gleichen Eigenschaften hinsichtlich DD und Mv wie das aus Krill hergestellte Chitosan. Der Bedarf an Zeit, Energie und NaOH ist für die Herstellung von Insekten-Chitosan geringer als für crabshell-Chitosan vergleichbare Resultaten für DD und Mv. 2. Chitosan wurde durch den Schimmelpilz Aspergillus fumigatus zu Chitooligomeren fermentiert. Die Ausbeute beträgt 25%. Die Chitooligomere wurden mit Hilfe von HPLC und MALDI-TOF-Massenspektrmetrie identifiziert. Die Fermentationsmischung fördert die Immunität von Pflanzen gegen Bakterien und Virusinfektion. Die Zunahme der Immunität schwankt jedoch je nach System Pflanze-Pathogen. Die Fermentation von Chitosan durch Aspergillus fumigatus könnte eine schnelle und billige Methode zur Herstellung von Chitooligomeren mit guter Reinheit und Ausbeute sein. Eine partiell aufgereinigte Fermentationsmischung dieser Art könnte in der Landwirtschaft als Pathogeninhibitor genutzt werden. Durch kontrollierte Fermentation, die Chitooligomere in definierter Zusammensetzung (d.h. definierter Verteilung des Depolymerisationsgrades) liefert, könnte man zu Mischungen kommen, die für die jeweilige Anwendung eine optimale Bioaktivität besitzen. 3

  17. OLIMPO: a balloon-borne, arcminute-resolution survey of the sky at mm and sub-mm wavelengths

    NASA Astrophysics Data System (ADS)

    Masi, S.; Ade, P.; Boscaleri, A.; de Bernardis, P.; de Petris, M.; de Troia, G.; Fabrini, M.; Iacoangeli, A.; Lamagna, L.; Lange, A.; Lubin, P.; Mauskopf, P.; Melchiorri, A.; Melchiorri, F.; Nati, L.; Nati, F.; Orlando, A.; Piacentini, F.; Pierre, M.; Pisano, G.; Polenta, G.; Rephaeli, Y.; Romeo, G.; Salvaterra, L.; Savini, G.; Valiante, E.; Yvon, D.

    2003-08-01

    We describe OLIMPO, a balloon-borne telescope devoted to cosmological and astrophysical surveys in the mm and sub-mm range. We summarize the relevant science (principally surveys of SZ clusters, of the sub-mm cosmic background and observations of galactic and cirrus dust) and the innovative sub-systems we have developed. The test flight of the telescope is planned for July 2004; the long duration flight is planned for the end of 2005.

  18. Public Library Subject Headings for 16mm Motion Pictures. Revised.

    ERIC Educational Resources Information Center

    California Library Association, Sacramento.

    Suggested subject headings for 16mm motion pictures are listed. The intent of the list is to provide audiovisual librarians with a tool which will aid them in making subject indexes for their printed catalogs. It is also intended as an authority for professional catalogers who may be called upon to catalog 16mm motion pictures. (Author/KKC)

  19. Is smaller better? Comparison of 3-mm and 5-mm leaf size for stereotactic radiosurgery: A dosimetric study

    SciTech Connect

    Chern, Shyh-shi . E-mail: Richard.Chern@hci.utah.edu; Leavitt, Dennis D.; Jensen, Randy L.; Shrieve, Dennis C.

    2006-11-15

    Purpose: To perform a dosimetric comparison of a minimal 3-mm leaf width multileaf collimator (MLC) and a minimal 5-mm MLC in dynamic conformal arc stereotactic radiosurgery for treatment of intracranial lesions. Methods and Materials: The treatment plans of 23 patients previously treated for intracranial lesions in our institution were redone using the BrainSCAN, version 5.3, stereotactic radiosurgery treatment planning system (BrainLAB). For each case, two dynamic conformal arc plans were generated: one using a minimal 3-mm micro-MLC (BrainLAB, Novalis) and one using a minimal 5-mm MLC (Varian Millennium). All arc parameters were the same in each of the two plans, except for the collimator angle settings. The collimator angle settings were optimized for each arc in each plan. A peritumoral rind structure (1 cm) was created to evaluate normal tissue sparing immediately adjacent to the target volume. Conformity indexes (CIs) were calculated for each plan. The dependence of normal tissue sparing and target conformity on target volume (TV) was determined. Results: The TV was 0.14-36.32 cm{sup 3} (median, 5.90). The CI was 1.22-2.60 (median, 1.51) for the 3-mm micro-MLC and 1.23-2.69 (median, 1.60) for the 5-mm MLC. Despite this small difference, it was a statistically significant increase (p < 0.0001) for the 5-mm MLC compared with the 3-mm micro-MLC. Improved normal tissue sparing was demonstrated using the 3-mm micro-MLC compared with the 5-mm MLC by examining the peritumoral rind volumes (PRVs) receiving 50% (PRV{sub 5}), 80% (PRV{sub 8}), and 90% (PRV{sub 9}) of the prescription dose. The reduction in the PRV{sub 5}, PRV{sub 8}, and PRV{sub 9} for the 3-mm micro-MLC compared with the 5-mm MLC was 13.5%, 12.9%, and 11.5%, respectively. The CI decreased with a larger TV, as did the difference in the CIs between the 3-mm micro-MLC and 5-mm MLC. A reduction in the PRV increased with larger TVs. Conclusion: The 3-mm micro-MLC provided better target conformity and

  20. Growth kinetics of 1-2 mm and 3-4 mm colonies of Nostoc sphaeroides (Cyanophyta) in outdoor culture.

    PubMed

    Deng, Zhongyang; Yan, Chunlan; Lu, Fan; Hu, Qiang; Hu, Zhengyu

    2008-10-01

    Nostoc sphaeroides Kützing was cultivated in paddlewheel-driven raceway ponds and the growth kinetics of 1-2 mm and 3-4 mm colonies of N. sphaeroides was studied. The biomass productivities in 2.5 m(2) raceway ponds inoculated with 1-2 mm and 3-4 mm colonies were 5.2 and 0.25 g dry wt m(-2) d(-1), respectively. Furthermore, differently sized colonies showed different relative water content, total soluble carbohydrates, chlorophyll a content and density of filaments. This is the first report on mass culture of N. sphaeroides under outdoor conditions.

  1. Amplitude modulation drive to rectangular-plate linear ultrasonic motors with vibrators dimensions 8 mm x 2.16 mm X 1 mm.

    PubMed

    Ming, Yang; Hanson, Ben; Levesley, Martin C; Walker, Peter G; Watterson, Kevin G

    2006-12-01

    In this paper, to exploit the contribution from not only the stators but also from other parts of miniature ultrasonic motors, an amplitude modulation drive is proposed to drive a miniature linear ultrasonic motor consisting of two rectangular piezoelectric ceramic plates. Using finite-element software, the first longitudinal and second lateral-bending frequencies of the vibrator are shown to be very close when its dimensions are 8 mm x 2.16 mm x 1 mm. So one single frequency power should be able to drive the motor. However, in practice the motor is found to be hard to move with a single frequency power because of its small vibration amplitudes and big frequency difference between its longitudinal and bending resonance, which is induced by the boundary condition variation. To drive the motor effectively, an amplitude modulation drive is used by superimposing two signals with nearly the same frequencies, around the resonant frequency of the vibrators of the linear motor. When the amplitude modulation frequency is close to the resonant frequency of the vibrator's surroundings, experimental results show that the linear motor can move back and forward with a maximum thrust force (over 0.016 N) and a maximum velocity (over 50 mm/s).

  2. Japanese Science Films; a Descriptive and Evaluative Catalog of: 16mm Motion Pictures, 8mm Cartridges, and Video Tapes.

    ERIC Educational Resources Information Center

    Newren, Edward F., Ed.

    One hundred and eighty Japanese 16mm motion pictures, 8mm cartridges, and video tapes produced and judged appropriate for a variety of audience levels are listed in alphabetical order by title with descriptive and evaluative information. A subject heading list and a subject index to the film titles are included, as well as a sample of the…

  3. The 19 mm data recorders similarities and differences

    NASA Technical Reports Server (NTRS)

    Atkinson, Steve

    1992-01-01

    Confusion over the use of non-video 19 mm data recorders is becoming more pronounced as we enter the world of high performance computing. This paper addresses the following: the differences between ID-1, ID-2, MIL-STD-2179 and DD-2; what the proper machine is for various applications; how the machine can be integrated into an environment; and any misconceptions there might be about 19 mm tape recorders. DD-2 and 19 mm instrumentation recorders have missions for which each is well designed. While the differences may appear subtle, understanding the difference between the two is the key to picking the right recorder for a particular application.

  4. 120MM Mortar MIL-STD-1660 Tests

    DTIC Science & Technology

    1994-07-01

    AD-A285 065 FINAL REPORT JULY 1994 REPORT NO. 91-18 120MM MORTAR MIL- STD - 1660 TESTS 94-309 󈧷 Prepared for: Dist.iviiior Unlimited I I U.S. Army...Inidude Securt Ciassificz ion) 120MM Mortar MIL- STD - i660 Tests 12- PERSONAL AUTHOR IS) William R. Meyer ~13a. TYPE OF REPORT 13b. TINE COVERED 14...Armnament Re- earch, Development and Engineering Center (ARDEC), SMCAR-AEP, to conduct MIL- STD - 1660 tests on 120M,\\M mortar rounds on wooden p~allets

  5. Growth of 450 mm diameter semiconductor grade silicon crystals

    NASA Astrophysics Data System (ADS)

    Lu, Zheng; Kimbel, Steven

    2011-03-01

    Research and development of the next generation 450 mm semiconductor grade silicon crystal and related technology have been carried out in MEMC following the company's philosophy to stay one generation ahead on research and development. The first 450 mm dislocation free crystal was grown in early 2009 and the first 450 mm semiconductor wafer was produced shortly after. General challenges in crystal growth process, puller, and hot zone designs, as well as control, automation, and handling are discussed in this paper. General considerations on working with customers and equipment manufacturers on fundamental crystal and wafer quality characteristics are also discussed.

  6. Grundlagen und Vollzug der amtlichen Lebensmittelkontrolle in der Schweiz

    NASA Astrophysics Data System (ADS)

    Hübner, Philipp; Spinner, Christoph

    In der Schweiz wird die Mehrheit der hoheitlichen Aufgaben von den 26 Kantonen, die zusammen die schweizerische Eidgenossenschaft bilden, autonom vollzogen. So liegt zum Beispiel die Kompetenz in den Bereichen Steuern, Gesundheit, Schulen oder Polizei grundsätzlich bei den Kantonen. Im Gegensatz dazu ist die Lebensmittelgesetzgebung national durch eidgenössische Erlasse harmonisiert. Die Vollzugsaufgaben liegen aber auch in diesem Bereich, abgesehen vom Vollzug an der Grenze und von einer nationalen Vollzugsaufsicht und Weisungsberechtigung, in kantonaler Kompetenz. Die Kantone können anhand kantonaler Erlasse das Bundesrecht präzisieren - insbesondere die organisatorischen Aspekte - und Regelungen im nicht harmonisierten Bereich treffen.

  7. Advanced Applications Flight Equipment (AAFE) 125mm ultraviolet spectrometer

    NASA Technical Reports Server (NTRS)

    Schroeder, R. J.

    1973-01-01

    The conceptual work is reported for the 125 mm ultraviolet spectrometer to measure atmospheric ozone as a function of height, latitude, and time. The instrument is described along with the assembly, test, and calibration.

  8. Building 931, oblique view to southeast, 135 mm lens. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building 931, oblique view to southeast, 135 mm lens. - Travis Air Force Base, Central Battery Charging Building, North of W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

  9. Building 904, oblique view to southeast, 135 mm lens. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building 904, oblique view to southeast, 135 mm lens. - Travis Air Force Base, Base Spares Warehouse No. 1, Dixon Avenue & W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

  10. Building 1204, oblique view to west, 135 mm lens. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building 1204, oblique view to west, 135 mm lens. - Travis Air Force Base, Squadron Operations & Readiness Crew Facility, W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

  11. Building 909, oblique view to southeast, 135 mm lens. Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building 909, oblique view to southeast, 135 mm lens. Building 908 at extreme right for context. - Travis Air Force Base, Handling Crew Building, North of W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

  12. Building 1204, oblique view to east, 90 mm lens. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building 1204, oblique view to east, 90 mm lens. - Travis Air Force Base, Squadron Operations & Readiness Crew Facility, W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

  13. Building 904, oblique view to northeast, 210mm lens Travis ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building 904, oblique view to northeast, 210mm lens - Travis Air Force Base, Base Spares Warehouse No. 1, Dixon Avenue & W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

  14. Building 932, oblique view to northwest, 90 mm lens. Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building 932, oblique view to northwest, 90 mm lens. Building 933-935 at extreme left. - Travis Air Force Base, Nuclear Weapons Assembly Plant 5, W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

  15. Building 931, oblique view to northwest, 210 mm lens. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building 931, oblique view to northwest, 210 mm lens. - Travis Air Force Base, Central Battery Charging Building, North of W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

  16. Building 904, oblique view to northwest, 135 mm lens ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building 904, oblique view to northwest, 135 mm lens - Travis Air Force Base, Base Spares Warehouse No. 1, Dixon Avenue & W Street, Armed Forces Special Weapons Project Q Area, Fairfield, Solano County, CA

  17. QM/MM methods for studying enzymatic reactions of glycosyltransferases.

    PubMed

    Tvaroška, Igor

    2015-01-01

    Hybrid quantum mechanics and molecular mechanics (QM/MM) methods have become a powerful tool to provide an accurate and effective description of complex biological systems. The QM treatment of the electronic structure of an active site region and the rest of the enzyme by molecular mechanics allows enzymatic reaction to being modeled with including the impact of environment. Different reaction pathways of the enzymatic mechanism can be tested--transition states (TS) and intermediates characterized using QM/MM methods, leading to significant advances in understanding enzymatic reactions. This chapter discusses the ideas and the setting up of the structural and computational models for calculations with QM/MM software. The use of QM/MM methodology is also illustrated using the case of the inverting glycosyltransferase GnT-I.

  18. The 19 mm date recorders: Similarities and differences

    NASA Technical Reports Server (NTRS)

    Atkinson, Steve

    1991-01-01

    Confusion over the use of non-video 19 mm data recorders is becoming more pronounced in the world of high performance computing. The following issues are addressed: (1) the difference between ID-1, ID-2, MIL-STD-2179, and DD-2; (2) the proper machine for the necessary application; and (3) integrating the machine into an existing environment. Also, an attempt is made to clear up any misconceptions there might be about 19 mm tape recorders.

  19. [Degradation of oil derivatives by Acinetobacter calcoaceticus MM5].

    PubMed

    Marín, M M; Ortiz, M L; Laborda, F

    1994-01-01

    This paper describes the isolation of microorganisms from polluted heating oil. The growth of one of them has been studied (Acinetobacter calcoaceticus MM5) in several linear and branched hydrocarbons as well as the effect of its growth on commercial diesel oil. Acinetobacter calcoaceticus MM5 is not capable of using glucose as its only source of carbon, and it needs the presence of nitrogen and phosphorus sources to degrade any petroleum by-product.

  20. QM/MM free energy simulations: recent progress and challenges.

    PubMed

    Lu, Xiya; Fang, Dong; Ito, Shingo; Okamoto, Yuko; Ovchinnikov, Victor; Cui, Qiang

    Due to the higher computational cost relative to pure molecular mechanical (MM) simulations, hybrid quantum mechanical/molecular mechanical (QM/MM) free energy simulations particularly require a careful consideration of balancing computational cost and accuracy. Here we review several recent developments in free energy methods most relevant to QM/MM simulations and discuss several topics motivated by these developments using simple but informative examples that involve processes in water. For chemical reactions, we highlight the value of invoking enhanced sampling technique (e.g., replica-exchange) in umbrella sampling calculations and the value of including collective environmental variables (e.g., hydration level) in metadynamics simulations; we also illustrate the sensitivity of string calculations, especially free energy along the path, to various parameters in the computation. Alchemical free energy simulations with a specific thermodynamic cycle are used to probe the effect of including the first solvation shell into the QM region when computing solvation free energies. For cases where high-level QM/MM potential functions are needed, we analyze two different approaches: the QM/MM-MFEP method of Yang and co-workers and perturbative correction to low-level QM/MM free energy results. For the examples analyzed here, both approaches seem productive although care needs to be exercised when analyzing the perturbative corrections.

  1. SPECTRAL LINE SURVEY TOWARD THE YOUNG MASSIVE PROTOSTAR NGC 2264 CMM3 IN THE 4 mm, 3 mm, AND 0.8 mm BANDS

    SciTech Connect

    Watanabe, Yoshimasa; Sakai, Nami; López-Sepulcre, Ana; Furuya, Ryuta; Yamamoto, Satoshi; Sakai, Takeshi; Hirota, Tomoya; Liu, Sheng-Yuan; Su, Yu-Nung

    2015-08-20

    Spectral line survey observations are conducted toward the high-mass protostar candidate NGC 2264 CMM3 in the 4, 3, and 0.8 mm bands with the Nobeyama 45 m telescope and the Atacama Submillimeter Telescope Experiment (ASTE) 10 m telescope. In total, 265 emission lines are detected in the 4 and 3 mm bands, and 74 emission lines in the 0.8 mm band. As a result, 36 molecular species and 30 isotopologues are identified. In addition to the fundamental molecular species, many emission lines of carbon-chain molecules such as HC{sub 5}N, C{sub 4}H, CCS, and C{sub 3}S are detected in the 4 and 3 mm bands. Deuterated molecular species are also detected with relatively strong intensities. On the other hand, emission lines of complex organic molecules such as HCOOCH{sub 3} and CH{sub 3}OCH{sub 3} are found to be weak. For the molecules for which multiple transitions are detected, rotation temperatures are derived to be 7–33 K except for CH{sub 3}OH. Emission lines with high upper-state energies (E{sub u} > 150 K) are detected for CH{sub 3}OH, indicating the existence of a hot core. In comparison with the chemical composition of the Orion KL, carbon-chain molecules and deuterated molecules are found to be abundant in NGC 2264 CMM3, while sulfur-bearing species and complex organic molecules are deficient. These characteristics indicate the chemical youth of NGC 2264 CMM3 in spite of its location at the center of the cluster forming core, NGC 2264 C.

  2. Spectral Line Survey toward the Young Massive Protostar NGC 2264 CMM3 in the 4 mm, 3 mm, and 0.8 mm Bands

    NASA Astrophysics Data System (ADS)

    Watanabe, Yoshimasa; Sakai, Nami; López-Sepulcre, Ana; Furuya, Ryuta; Sakai, Takeshi; Hirota, Tomoya; Liu, Sheng-Yuan; Su, Yu-Nung; Yamamoto, Satoshi

    2015-08-01

    Spectral line survey observations are conducted toward the high-mass protostar candidate NGC 2264 CMM3 in the 4, 3, and 0.8 mm bands with the Nobeyama 45 m telescope and the Atacama Submillimeter Telescope Experiment (ASTE) 10 m telescope. In total, 265 emission lines are detected in the 4 and 3 mm bands, and 74 emission lines in the 0.8 mm band. As a result, 36 molecular species and 30 isotopologues are identified. In addition to the fundamental molecular species, many emission lines of carbon-chain molecules such as HC5N, C4H, CCS, and C3S are detected in the 4 and 3 mm bands. Deuterated molecular species are also detected with relatively strong intensities. On the other hand, emission lines of complex organic molecules such as HCOOCH3 and CH3OCH3 are found to be weak. For the molecules for which multiple transitions are detected, rotation temperatures are derived to be 7-33 K except for CH3OH. Emission lines with high upper-state energies (Eu > 150 K) are detected for CH3OH, indicating the existence of a hot core. In comparison with the chemical composition of the Orion KL, carbon-chain molecules and deuterated molecules are found to be abundant in NGC 2264 CMM3, while sulfur-bearing species and complex organic molecules are deficient. These characteristics indicate the chemical youth of NGC 2264 CMM3 in spite of its location at the center of the cluster forming core, NGC 2264 C.

  3. Methodik und Qualität statistischer Erhebungen

    NASA Astrophysics Data System (ADS)

    Krug, Walter; Schmidt, Jürgen; Wiegert, Rolf

    Kapitel 8 wirft einen Blick hinter die Kulissen statistischer Arbeit und ihrer Methoden, insbesondere auch hinter die der amtlichen Statistik: Wie kommen die Myriaden von Zahlen zustande, die heute aus statistischen Quellenwerken aller Art und aus Datenbanken abgerufen werden können? Dabei wird deutlich, welche Schwierigkeiten bei Erhebungen, insbesondere bei Stichprobenerhebungen, zu überwinden sind, wie man Antwortverweigerer kooperativer stimmt, wie sich auch aus kleinen Stichproben auf intelligente Weise verlässliche Ergebnisse erzielen lassen und wie Großstichproben auf europäischer Ebene harmonisiert werden. Am Beispiel des Zensus 2011 wird gezeigt, wie sich eine Kombination von Stichproben und Registerauswertungen als Ersatz für eine Volkszählung nutzen lässt. Mitglieder der Deutschen Statistischen Gesellschaft waren daran kooperativ beteiligt.

  4. Konstruieren von Pkw-Karosserien: Grundlagen, Elemente und Baugruppen, Vorschriftenübersicht, Beispiele mit CATIA V4 und V5

    NASA Astrophysics Data System (ADS)

    Grabner, Jörg; Nothhaft, Richard

    Die Faszination, die vom Auto ausgeht, ist und bleibt ungebrochen. Entsprechend interessant ist es, sich vor dem Hintergrund konventioneller Konstruktionstechniken über die virtuelle Produktentwicklung von Pkw-Karosserien an modernen CAD-Arbeitsplätzen informieren zu können. Die Autoren führen in die Grundlagen ein und zeigen anhand von Beispielen und zahlreichen Abbildungen, wie mit dem System CATIA der Rohbau sowie die Ausstattung innen und au=C3=9Fen konstruiert werden. Darüber hinaus wird das so genannte "Package" an Beispielen beschrieben, also das Management und die Harmonisierung der Anforderungen an die Bauräume (z.

  5. The same-source parallel MM{sub 5}.

    SciTech Connect

    Michalakes, J.

    1999-08-23

    The set of architectures available to users of the Penn State/NCAR MM5 has been expanded to included distributed-memory parallel computers, providing cost-effective scalable performance and memory capacity for large problem sizes. The same-source approach uses high-level parallel library and source-translation technology for adapting MM5, simplifying maintenance and allowing new physics modules to be incorporated without modification. The approach facilitates maintenance of the DM-parallel option to MM5 as an option within the official version, rather than as a separate stand-alone version. As a result, the DM-parallel option to MM5 (now at Version 3.1) has been a part of six subsequent model releases since MM5 Version 2.8 in March 1998. The same-source approach is applicable to other, similarly constructed codes when there is a need or desire to develop the code for distributed memory parallel machines without impacting the pre-existing source code. The approach is also compatible with pre-existing loop-level multithreading directives so that the code will run in distributed-memory/shared-memory mode on SMP clusters.

  6. CMOS mm-wave transceivers for Gbps wireless communication

    NASA Astrophysics Data System (ADS)

    Baoyong, Chi; Zheng, Song; Lixue, Kuang; Haikun, Jia; Xiangyu, Meng; Zhihua, Wang

    2016-07-01

    The challenges in the design of CMOS millimeter-wave (mm-wave) transceiver for Gbps wireless communication are discussed. To support the Gbps data rate, the link bandwidth of the receiver/transmitter must be wide enough, which puts a lot of pressure on the mm-wave front-end as well as on the baseband circuit. This paper discusses the effects of the limited link bandwidth on the transceiver system performance and overviews the bandwidth expansion techniques for mm-wave amplifiers and IF programmable gain amplifier. Furthermore, dual-mode power amplifier (PA) and self-healing technique are introduced to improve the PA's average efficiency and to deal with the process, voltage, and temperature variation issue, respectively. Several fully-integrated CMOS mm-wave transceivers are also presented to give a short overview on the state-of-the-art mm-wave transceivers. Project supported in part by the National Natural Science Foundation of China (No. 61331003).

  7. Physik gestern und heute Von der Metallstange zum Hochenergielaser

    NASA Astrophysics Data System (ADS)

    Heering, Peter

    2002-05-01

    Im Mai 1752 wurde in Marly bei Paris auf Anregung des amerikanischen Forschers und Politikers Benjamin Franklin erstmals die elektrische Natur des Blitzes nachgewiesen. Damals beschrieb Franklin auch eine technische Vorrichtung, die als Schutz von Gebäuden vor Blitzschlägen dienen sollte: den Blitzableiter. Diese aus heutiger Sicht scheinbar triviale Vorrichtung wurde aber keineswegs unmittelbar akzeptiert. Und bis heute ist die Forschung zum Schutz von Einrichtungen vor Blitzschlägen nicht abgeschlossen.

  8. New Methods for Exploring QM:MM Potential Energy Landscapes

    NASA Astrophysics Data System (ADS)

    Hratchian, Hrant P.

    2010-06-01

    In recent years, the applicability of quantum chemical methods for large system studies has been greatly enhanced by the development of hybrid QM:MM techniques. Despite these advancements, exploring the associated potential energy surfaces continues to present two key challenges. First, the QM energy and derivative evaluations may be too costly for simulations; and second, the system size for many QM:MM cases are too large to effectively store or use second-order information, an approach often used in QM studies to allow for larger integration steps and fewer QM evaluations of the potential energy surface. Our most recent work is focused on overcoming both computational bottlenecks. Using surface fitting models together with direct Hessian-vector and diagonalization algorithms, we are developing models that can accurately and efficiently explore QM:MM potential energy landscapes for very large systems. Our current development status and results from initial applications will be described.

  9. QM/MM X-ray Refinement of Zinc Metalloenzymes

    PubMed Central

    Li, Xue; Hayik, Seth A.; Merz, Kenneth M.

    2010-01-01

    Zinc metalloenzymes play an important role in biology. However, due to the limitation of molecular force field energy restraints used in X-ray refinement at medium or low resolutions, the precise geometry of the zinc coordination environment can be difficult to distinguish from ambiguous electron density maps. Due to the difficulties involved in defining accurate force fields for metal ions, the QM/MM (Quantum-Mechanical /Molecular-Mechanical) method provides an attractive and more general alternative for the study and refinement of metalloprotein active sites. Herein we present three examples that indicate that QM/MM based refinement yields a superior description of the crystal structure based on R and Rfree values and on the inspection of the zinc coordination environment. It is concluded that QM/MM refinement is a useful general tool for the improvement of the metal coordination sphere in metalloenzyme active sites. PMID:20116858

  10. S1-Leitlinie zur UV-Phototherapie und Photochemotherapie.

    PubMed

    Herzinger, Thomas; Berneburg, Mark; Ghoreschi, Kamran; Gollnick, Harald; Hölzle, Erhard; Hönigsmann, Herbert; Lehmann, Percy; Peters, Thorsten; Röcken, Martin; Scharffetter-Kochanek, Karin; Schwarz, Thomas; Simon, Jan; Tanew, Adrian; Weichenthal, Michael

    2016-08-01

    Die heilsame Wirkung des Sonnenlichts war teilweise schon im Altertum bekannt und fand in der zweiten Hälfte des 19. Jahrhunderts wieder zunehmend Beachtung. Den Beginn der modernen Phototherapien markiert die Entwicklung einer Apparatur zur ultravioletten Bestrahlung der Hauttuberkulose durch Finnsen zu Beginn des zwanzigsten Jahrhunderts. Zur Therapie von Hauterkrankungen finden beinahe ausschließlich die spektralen Bereiche unterhalb des sichtbaren Lichtes (ultraviolett) Anwendung. Seit den 1970er Jahren stehen zunehmend leistungsfähige künstliche Strahlenquellen bereit für die Therapie mit UVB, UVA und die Kombination von UVA mit Photosensibilisatoren (Photochemotherapie). Hohe strukturelle und prozedurale Qualitätsstandards sind unabdingbare Voraussetzung für die Durchführung einer gleichermaßen wirkungsvollen wie auch sicheren Phototherapie. Die Leitlinie formuliert den aktuellen Konsens führender Experten auf dem Gebiet der Phototherapie in Bezug auf die Indikationen für die jeweiligen Therapieverfahren, deren Gegenanzeigen und Nebenwirkungen und insbesondere für die Wahl der korrekten Dosis zu Beginn und im Verlauf einer Therapie sowie das Management von Nebenwirkungen.

  11. Zahlen und Rechenvorgänge auf unterschiedlichen Abstraktionsniveaus

    NASA Astrophysics Data System (ADS)

    Rödler, Klaus

    "Das Verständnis geht langsam vor sich!" Diesen wichtigen Satz hörte ich bei einem Vortrag von Martin Lowsky. Auf die hier behandelte Fragestellung übertragen heißt das: Was eine Zahl ist und wie ich sie im Rechenvorgang einsetzen und interpretieren kann, das erschließt sich erst allmählich. Die Zahl des Rechenanfängers ist nicht dieselbe wie die des kompetenten Rechners und es ist nicht die Zahl des Lehrers oder der Lehrerin. Die Zahlen sind nur auf der Oberfläche der Worte und Zeichen gleich. Im Innern, im Verständnis, sind sie völlig verschieden! Ich glaube, dass die Missachtung dieser Divergenz dazu führt, dass manche Kinder in für den Lehrer und Lehrerin nicht nachvollziehbaren Routinen stecken bleiben, einfachste Informationen nicht wirklich integrieren. Die auf beiden Seiten wachsende Verunsicherung durch die nicht erkannte und daher nicht kommunizierbare Diskrepanz im inneren Zahlkonzept stört den allmählichen Aufbau strukturierter Zahlvorstellungen.

  12. 450mm wafer patterning with jet and flash imprint lithography

    NASA Astrophysics Data System (ADS)

    Thompson, Ecron; Hellebrekers, Paul; Hofemann, Paul; LaBrake, Dwayne L.; Resnick, Douglas J.; Sreenivasan, S. V.

    2013-09-01

    The next step in the evolution of wafer size is 450mm. Any transition in sizing is an enormous task that must account for fabrication space, environmental health and safety concerns, wafer standards, metrology capability, individual process module development and device integration. For 450mm, an aggressive goal of 2018 has been set, with pilot line operation as early as 2016. To address these goals, consortiums have been formed to establish the infrastructure necessary to the transition, with a focus on the development of both process and metrology tools. Central to any process module development, which includes deposition, etch and chemical mechanical polishing is the lithography tool. In order to address the need for early learning and advance process module development, Molecular Imprints Inc. has provided the industry with the first advanced lithography platform, the Imprio® 450, capable of patterning a full 450mm wafer. The Imprio 450 was accepted by Intel at the end of 2012 and is now being used to support the 450mm wafer process development demands as part of a multi-year wafer services contract to facilitate the semiconductor industry's transition to lower cost 450mm wafer production. The Imprio 450 uses a Jet and Flash Imprint Lithography (J-FILTM) process that employs drop dispensing of UV curable resists to assist high resolution patterning for subsequent dry etch pattern transfer. The technology is actively being used to develop solutions for markets including NAND Flash memory, patterned media for hard disk drives and displays. This paper reviews the recent performance of the J-FIL technology (including overlay, throughput and defectivity), mask development improvements provided by Dai Nippon Printing, and the application of the technology to a 450mm lithography platform.

  13. Modifications of und rbcS in und Synechococcus sp. PCC7942 resulted in high CO sub 2 requiring mutants

    SciTech Connect

    Schwarz, R.; Liehman-Hurwitz, J.; Martinez, F.; Reinhold, L.; Kaplan, A. )

    1990-05-01

    High CO{sub 2} requiring mutants (HCR), capable of growing in the presence of kanamycin, were obtained following transformation with a construct containing {und nptII} in the coding region of rbcS (encoding for the small subunit (SS) of Rubisco). The apparent photosynthetic affinity for inorganic carbon was very low in mutant EK6 whereas in mutant JR12 it was only slightly lower than in high-CO{sub 2}-grown wild type. Southern analysis indicated double crossing over in the case of EK6. In mutant JR12 Southern analysis revealed some rearrangement and a deletion of a region downstream fro {und rbcS}. Western analysis demonstrated normal SS in JR12 but a larger (by about 3 kD) SS in EK6. Sequence analysis indicated that the latter was the result of fusion between {und rbcS} and the flanking region of {und nptII}.

  14. Novel Processing of 81-mm Cu Shaped Charge Liners

    SciTech Connect

    Schwartz, A; Korzekwa, D

    2002-01-16

    A seven-step procedure was developed for producing shaped charge liner blanks by back extrusion at liquid nitrogen temperatures. Starting with a 38.1-mm diameter, 101.6-mm long cylinder at 77K, three forging steps with a flat-top die are required to produce the solid cone while maintaining low temperature. The solid cone is forged in four individual back extrusions at 77K to produce the rough liner blank. This procedure is capable of being run in batch processes to improve the time efficiency.

  15. Regelungen im Verkehr mit Lebensmitteln und Bedarfsgegenständen in Deutschland

    NASA Astrophysics Data System (ADS)

    Thomas, Gundula; Freund, Astrid; Gründig, Friedrich

    Im Zuge der Globalisierung von Produktion und Handel ändert sich auch der Charakter der Vorschriften im Lebensmittelrecht. Zunehmend treten internationale Rechtsbestimmungen, Abkommen, Standards und andere Normen an die Stelle nationaler Regelungen.

  16. VDI-Richtlinien - mit Technischen Regeln Wirtschaftlichkeit erhöhen und Standards setzen

    NASA Astrophysics Data System (ADS)

    Mandelartz, Johannes

    Der Verein Deutscher Ingenieure e.V. (VDI) ist ein gemeinnütziger, wirtschaftlich und politisch unabhängiger, technisch-wissenschaftlicher Verein von Ingenieuren und Naturwissenschaftlern. Mit über 137 000 persönlich zugeordneten Mitgliedern ist er eine der größten Ingenieur-Vereinigungen Europas und gilt in Deutschland als führender Sprecher der Technik und der Ingenieure. 1856 gegründet, hat er viele für die Technik wesentliche Entwicklungen in Gang gesetzt, so im Bereich der technischen Überwachung, der technischen Regelsetzung und Normung, der Arbeitsstudien, im gewerblichen Rechtsschutz und im Patentwesen. Seit seiner Gründung sieht es der VDI als seine Aufgabe, "das Zusammenwirken aller geistiger Kräfte der Technik im Bewusstsein ethischer Verantwortung zu fördern“ und die Lebensmöglichkeiten aller Menschen durch Entwicklung und sinnvoller Anwendung technischer Mittel zu verbessern.

  17. Guide to Free-Loan Sports Films (16mm).

    ERIC Educational Resources Information Center

    1974

    This catalog provides information on free 16 mm films dealing with a wide variety of individual and team sports, such as football, golf, water sports, snow sports, racing, and baseball, as well as on general sports competition and safety. Unless otherwise noted, the films are in color and with sound. Titles are listed alphabetically under their…

  18. Propellant Residues Deposition from Firing of 40-mm Grenades

    DTIC Science & Technology

    2010-09-01

    the snow surface downrange of the firing positions in three sampling units on each pad. Samples were analyzed and results compo- sited to derive an...Processing and Analysis ..................................................................... 10 3.1 Snow samples...mm howitzers, propel- lant residues containing DNT were collected from the snow -covered area in front of one of the guns (Walsh, M.E. et al. 2004

  19. Downslope windstorm in Iceland - WRF/MM5 model comparison

    NASA Astrophysics Data System (ADS)

    Rögnvaldsson, Ó.; Bao, J.-W.; Ágústsson, H.; Ólafsson, H.

    2011-01-01

    A severe windstorm downstream of Mt. Öræfajökull in Southeast Iceland is simulated on a grid of 1 km horizontal resolution by using the PSU/NCAR MM5 model and the Advanced Research WRF model. Both models are run with a new, two equation planetary boundary layer (PBL) scheme as well as the ETA/MYJ PBL schemes. The storm is also simulated using six different micro-physics schemes in combination with the MYJ PBL scheme in WRF, as well as one "dry" run. Output from a 3 km MM5 domain simulation is used to initialise and drive both the 1 km MM5 and WRF simulations. Both models capture gravity-wave breaking over Mt. Öræfajökull, while the vertical structure of the lee wave differs between the two models and the PBL schemes. The WRF simulated downslope winds, using both the MYJ and 2EQ PBL schemes, are in good agreement with the strength of the observed downslope windstorm. The MM5 simulated surface winds, with the new two equation model, are in better agreement to observations than when using the ETA scheme. Micro-physics processes are shown to play an important role in the formation of downslope windstorms and a correctly simulated moisture distribution is decisive for a successful windstorm prediction. Of the micro-physics schemes tested, only the Thompson scheme captures the downslope windstorm.

  20. Advisory List of Instructional Media--16MM Films.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh. Div. of Educational Media.

    These two advisory lists include information on 16mm films appropriate for the K-12 instructional program. In both bibliographies films are listed in the following categories: communication skills; guidance; health, physical education, safety, and sports; science; and social studies. The list for the 1982-1983 school year also includes categories…

  1. Guide to Films (16 mm) About Ecology, Adaptation and Pollution.

    ERIC Educational Resources Information Center

    1971

    Synopses of 350 films (16 mm.) on ecology, adaptation of plants and animals to their environment, and environmental pollution are listed alphabetically by title in this guide. It specifies whether the film is black-and-white or color, its running time, and its source. An abbreviated subject index and a directory of sources are also provided. The…

  2. IMPLEMENTATION OF AN URBAN CANOPY PARAMETERIZATION IN MM5

    EPA Science Inventory

    The Pennsylvania State University/National Center for Atmospheric Research Mesoscale Model (MM5) (Grell et al. 1994) has been modified to include an urban canopy parameterization (UCP) for fine-scale urban simulations (~1-km horizontal grid spacing). The UCP accounts for drag ...

  3. LIGA-fabricated compact mm-wave linear accelerator cavities.

    SciTech Connect

    Song, J.J.; Bajikar, S.S.; DeCarlo, F.; Kang, Y.W.; Kustom, R.L.; Mancini, D.C.; Nassiri, A.; Lai, B.; Feinerman, A.D.; White, V.

    1998-03-23

    Millimeter-wave rf cavities for use in linear accelerators, free-electron lasers, and mm-wave undulatory are under development at Argonne National Laboratory. Typical cavity dimensions are in the 1000 mm range, and the overall length of the accelerator structure, which consists of 30-100 cavities, is about 50-100 mm. An accuracy of 0.2% in the cavity dimensions is necessary in order to achieve a high Q-factor of the cavity. To achieve this these structures are being fabricated using deep X-ray lithography, electroforming, and assembly (LIGA). The first prototype cavity structures are designed for 108 GHz and 2p/3-mode operation. Input and output couplers are integrated with the cavity structures. The cavities are fabricated on copper substrates by electroforming copper into 1-mm-thick PMMA resists patterned by deep x-ray lithography and polishing the copper down to the desired thickness. These are fabricated separately and subsequently assembled with precision spacing and alignment using microspheres, optical fibers, or microfabricated spacers/alignment pieces. Details of the fabrication process, alignment, and assembly work are presented in here.

  4. Bell & Howell Introduces an 8mm Cartridge Concept

    ERIC Educational Resources Information Center

    Educ Screen Audiovisual Guide, 1970

    1970-01-01

    "Bell & Howell has developed a highly versatile cartidge projector system for cine and super 8mm formats. Because Bell & Howell believes that standardization is an important factor in the development of a cartridge system, it has built in a flexibility which will allow this standardization. (Author)

  5. VLA 7-mm Observations of Massive Star-forming Regions

    NASA Astrophysics Data System (ADS)

    Linz, Hendrik; Hofner, Peter; Araya, Esteban; Stecklum, Bringfried

    2003-07-01

    The early stages during the formation of massive stars are deeply enshrouded due to the presence of dense and dusty natal material. This prevents observations in the optical and often also in the near-infrared. The emission of the star-forming regions peaks in the far-infrared and sub-mm regime, but at these wavelengths, single-dish observations are restricted in spatial resolution and can give only upper limits on the energetics of the objects of interest. Interferometry at mm wavelengths is one appropriate technique to overcome these limitations. We have started an extensive programme to observe pre-selected massive star-forming regions. Our tool is the VLA and its 7-mm receiver system. The VLA can be operated in several antenna configurations delivering resolutions from 1.5 arcsec down to 0.05 arcsec, which is superior to other current mm-interferometers. Sub-arcsec resolution is strongly needed to disentangle the often crowded regions of high-mass star formation and to clearly separate our objects of interest from the adjacent ultracompact HII regions. At 7 mm we are on the save ground of the Rayleigh-Jeans limit even for emission of cold dust (a fact that is not always true for observations at smaller wavelengths). Almost all circumstellar density configurations are optically thin at 7 mm, thus, the observations will trace the total dust content. However, at 7 mm also the free-free emission from ionised gas (caused by the UV emission of the young massive stars) can contribute to the observed signal. Therefore, we have to identify and remove these "parasitic" constituents by extrapolating interferometric data obtained at cm-wavelengths. The targets are either taken from the list of Molinari (Molinari et al. 2000, A&A, 355, 617) or are well-known massive star-forming complexes, for which we have already acquired additional data at other wavelengths. We have started with observations at lower and medium resolution (1.5 - 0.5 arcsec) to distinguish candidates for

  6. Verbesserte Ausbildung für neue Betriebsleiter und -ingenieure - eine wichtige Investition in die Zukunft

    NASA Astrophysics Data System (ADS)

    Franta, Oliver

    Bedingt durch die Globalisierung und die damit einhergehende Verschärfung des Wettbewerbs befinden sich die Produktionsbetriebe der chemischen Industrie in stetigem Wandel. Für Betriebsleiter und Betriebsingenieure werden damit Fähigkeiten wie Kostenmanagement, Sozial- und Organisationskompetenz, Führungsqualifikationen und unternehmerisches Handeln immer wichtiger. Neben den Anforderungsprofilen bei Neueinstellungen ist dies auch bei der Fortbildung zu berücksichtigen. Das Trainingsprogramm der Evonik Degussa wurde daher durch die Konzeption neuer Seminare und die Anpassung bestehender Weiterbildungsmaßnahmen weiterentwickelt. Neben Vorträgen und Fallbeispielen sind ebenfalls die Durchführung von Planspielen sowie das Kennenlernen eines Produktionsbetriebes einer anderen Organisationseinheit enthalten. Ziel ist es vor allem die unternehmerische Orientierung neuer Betriebsleiter und -ingenieure zu fördern, die Innovationsgeschwindigkeit zu erhöhen und durch Kenntnis und Nutzung bereits anderweitig entwickelter Lösungen und Methoden die Produktivität zu steigern. Die Produktionsmeister werden aufgrund der Bedeutung dieser Funktion für die Führung der Mitarbeiter und bei der Umsetzung von Veränderungsprojekten in das Ausbildungsprogramm einbezogen. Der Erfolg des Trainingsprogramms zeigt sich an den Teilnehmerzahlen und den ausgesprochen positiven Rückmeldungen.

  7. Nicolaus Copernicus Gesamtausgabe. Band VI/1. Documenta Copernicana: Briefe (Texte und Übersetzungen).

    NASA Astrophysics Data System (ADS)

    Kühne, A.

    Im Auftrage der Kommission für die Copernicus-Gesamtausgabe, herausgegeben von H. M. Nobis und M. Folkerts. Band VI/1 wurde bearbeitet von A. Kühne unter Mitarbeit von F. Boockmann und S. Kirschner und Verwendung der Vorarbeiten von H. M. Nobis.

  8. A 10-mm MR-Conditional Unidirectional Pneumatic Stepper Motor

    PubMed Central

    Chen, Yue; Mershon, Christopher D.; Tse, Zion Tsz Ho

    2014-01-01

    Magnetic resonance (MR) conditional robotic devices facilitate accurate interventional procedures under MR imaging (MRI) guidance. For this purpose, a compact (10-mm diameter) MR-conditional stepper motor is presented. The device features seven key components, which contribute to a dense and easy to fabricate design. Alternating bursts of pressurized air and vacuum can drive the motor in 60° per step to achieve a maximum torque of 2.4 mNm. The relationship between torque and angular speed was investigated to demonstrate motor performance under different loading conditions. The stepper motor was tested in a GE 3T MRI scanner to verify its MR-compatibility. A maximum artifact width of 3 mm was measured in MRI images and a maximum signal-to-noise ratio reduction of 2.49% was recorded. PMID:25419104

  9. Robotic QM/MM-driven maturation of antibody combining sites.

    PubMed

    Smirnov, Ivan V; Golovin, Andrey V; Chatziefthimiou, Spyros D; Stepanova, Anastasiya V; Peng, Yingjie; Zolotareva, Olga I; Belogurov, Alexey A; Kurkova, Inna N; Ponomarenko, Natalie A; Wilmanns, Matthias; Blackburn, G Michael; Gabibov, Alexander G; Lerner, Richard A

    2016-10-01

    In vitro selection of antibodies from large repertoires of immunoglobulin (Ig) combining sites using combinatorial libraries is a powerful tool, with great potential for generating in vivo scavengers for toxins. However, addition of a maturation function is necessary to enable these selected antibodies to more closely mimic the full mammalian immune response. We approached this goal using quantum mechanics/molecular mechanics (QM/MM) calculations to achieve maturation in silico. We preselected A17, an Ig template, from a naïve library for its ability to disarm a toxic pesticide related to organophosphorus nerve agents. Virtual screening of 167,538 robotically generated mutants identified an optimum single point mutation, which experimentally boosted wild-type Ig scavenger performance by 170-fold. We validated the QM/MM predictions via kinetic analysis and crystal structures of mutant apo-A17 and covalently modified Ig, thereby identifying the displacement of one water molecule by an arginine as delivering this catalysis.

  10. A 300-nm compact mm-wave linac FEL design

    SciTech Connect

    Nassiri, A.; Kustom, R.L.; Kang, Y.W.

    1995-12-31

    Microfabrication technology offers an alternative method for fabricating precision, miniature-size components suitable for use in accelerator physics and commercial applications. The original R&D work at Argonne, in collaboration with the University of Illinois at Chicago, has produced encouraging results in the area of rf accelerating structure design, optical and x-ray masks production, deep x-ray lithography (LIGA exposures), and precision structural alignments. In this paper we will present a design study for a compact single pass mm-linac FEL to produce short wavelength radiation. This system will consists of a photocathode rf gun operated at 30 GHz, a 50-MeV superconducting constant gradient structure operated at 60 GHz, and a microundulator with 1-mm period. Initial experimental results on a scale model rf gun and microundulator will be presented.

  11. S-I-S mm-Wave Mixers and Detectors.

    DTIC Science & Technology

    1982-09-01

    286 (19849 ’Y. TOa L. Yml md U. Kawaks AppL fly. LaL 37,239 ’WM. 3 Ushy ad ClJ.huky. h idmuMX ku~ubkSdlme--(’N9 M&Vikapw. pbki.mm mW ApN~um, ussk by...amorphous barriers poses both potential advantages and disadvantages c nared to alternate fabrication techniques for both super-Schottky and Josephson

  12. Perforated Brake Efficiency Measurements Using a 20-mm Cannon

    DTIC Science & Technology

    1993-03-01

    and exterior surfaces. Pb is the time- dependent breech pressure of the propellant gas, P0 is atmospheric pressure , and A is the bore area. The second...term is the sum of the integrals of the pressure forces generated by the N individual vents. P, is the time- and position- dependent pressure acting...brake ........................................ 37 Bla. Pressure histories for round 19534, 120-mm standard brake at 30 calibers. Data used in report

  13. Residues from Live Fire Detonations of 155-mm Howitzer Rounds

    DTIC Science & Technology

    2005-07-01

    tests were conducted on an ice- and snow-covered range, which allowed us to sample the residues on an explosives- free surface and to visually...manufacturing impurity in RDX. We selected 155-mm rounds for testing because they are one of the top five most commonly used rounds in the U.S. arsenal...Delta River is a large anastomosing river with a cobble and gravel flood plain characterized, in winter, by intermixed ice and cobble bars. Although

  14. MM&T: Bibliography on Optical Testing with Appendix.

    DTIC Science & Technology

    1982-02-26

    I963-A ITI to TECHNICAL REPORT RH-CR-82-6’.-4 MM&T: BIBLIOGRAPHY ON OPTICAL TESTING WITH APPENDIX A. Comejo-Rodriguez Apdo..Postal 216 Puebla , Puebla ...15 Refs.). Descriptors: LENSES; OPTICAL TESTING; INTERFEROMETERS; LIGHT REFRACTION; VISION Identifiers: TALBOT INTERFEROMETERS; MOIRE FRINGES; LENS...here described. MARTIN, S. "INFLUENCE OF SURFACE DEFECTS ON THE GLARE CHARACTERISTICS OF A NIGHT VISION SYSTEM WITH REFRACTIVE OPTICS" Opt. Acta, 25

  15. A 37-mm Ceramic Gun Nozzle Stress Analysis

    DTIC Science & Technology

    2006-05-01

    A 37-mm Ceramic Gun Nozzle Stress Analysis by Xiaogang Huang , James Garner, and Paul Conroy ARL-TR-3804 May 2006...Gun Nozzle Stress Analysis Xiaogang Huang , James Garner, and Paul Conroy Weapons and Materials Research Directorate, ARL...622618.H8011 5e. TASK NUMBER 6. AUTHOR(S) Xiaogang Huang , James Garner, and Paul Conroy 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION

  16. Electric Field Tunable Microwave and MM-wave Ferrite Devices

    DTIC Science & Technology

    2010-04-30

    Electric Field Tunable Microwave and MM-wave Ferrite Devices (N00014-06-01-0167) Period of Performance: May 1, 2006-April 30, 2010 Principal...modes as a function of E. The coupling was strong and ranged from 1 to 30 MHz/(kV/cm). Ferrite - ferroelectric composites were used in microwave and...2005, focused on ME effects at microwave and millimeter wave frequencies in ferrite -ferroelectric composites. Studies were performed on basic

  17. 120mm Prestressed Carbon Fiber/Thermoplastic Overwrapped Gun Tubes

    DTIC Science & Technology

    2008-10-01

    YYYY) 30-10-2008 2. REPORT TYPE FINAL 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE 120mm Prestressed Carbon Fiber/Thermoplastic...successfully test fired. The first barrel was not prestressed and was reported on previously. This paper will focus on the other three barrels. The... prestress in the jacket. Dealing with these issues greatly complicated the manufacturing process to the point where mass-producing the barrels would

  18. mm-wave observations of stratospheric HCN at tropical latitudes

    NASA Technical Reports Server (NTRS)

    Jaramillo, M.; De Zafra, R. L.; Barrett, J. W.; Parrish, A.; Solomon, P. M.

    1988-01-01

    Middle and upper stratospheric HCN has been measured using ground-based mm-wave emission spectroscopy during a series of observations made in Mauna Kea, HI, in June 1986. A volume mixing ratio of 190 + or - 40 pptv at about 40 km, and a decrease of concentration with altitude that is considerably slower than that predicted by current models are found. This could be an indication of an atmospheric source of HCN as yet unidentified.

  19. Experimental investigations of 3 mm aperture PPLN structures

    NASA Astrophysics Data System (ADS)

    Kolker, D.; Pronyushkina, A.; Boyko, A.; Kostyukova, N.; Trashkeev, S.; Nuyshkov, B.; Shur, V.

    2017-01-01

    We are reporting about investigation of domestic 3 mm aperture periodically polled lithium niobate (PPLN) structures for cascaded mid-IR OPO. Wide aperture periodically poled MgO-doped lithium niobate (LiNbO3) structures at multigrating, fan-out and multi fan-out configuration were prepared at “Labfer LTD”. Laser source based on such structures can be used for special applications. Four different PPLN structures were investigated and effective aperture for effective pumping was defined.

  20. Enhancing Paradynamics for QM/MM Sampling of Enzymatic Reactions.

    PubMed

    Lameira, Jerônimo; Kupchencko, Ilya; Warshel, Arieh

    2016-03-10

    Despite the enormous increase in computer power, it is still extremely challenging to obtain computationally converging sampling of ab initio QM/MM (QM(ai)/MM) free energy surfaces in condensed phases. The sampling problem can be significantly reduced by the use of the reference potential paradynamics (PD) approach, but even this approach still requires major computer time in studies of enzymatic reactions. To further reduce the sampling problem we developed here a new PD version where we use an empirical valence bond reference potential that has a minimum rather than a maximum at the transition state region of the target potential (this is accomplished conveniently by shifting the EVB of the product state). Hence, we can map the TS region in a more efficient way. Here, we introduce and validate the inverted EVB PD approach. The validation involves the study of the S(N)2 step of the reaction catalyzed by haloakene dehalogenase (DhlA) and the GTP hydrolysis in the RasGAP system. In addition, we have also studied the corresponding reaction in water for each of the systems described here and the reaction involving trimethylsulfonium and dimethylamine in solution. The results are encouraging and the new strategy appears to provide a powerful way of evaluating QM(ai)/MM activation free energies.

  1. Ökophysik: Plaudereien über das Leben auf dem Land, im Wasser und in der Luft

    NASA Astrophysics Data System (ADS)

    Nachtigall, W.

    Prof. em. Dr. rer. nat. Werner Nachtigall, geb. 1934, war als Zoophysiologe und Biophysiker Leiter des Zoologischen Instituts der Universität des Saarlandes in Saarbrücken. In Forschung und Ausbildung hat er sich insbesondere mit Aspekten der Technischen Biologie und Bionik befasst und mit seinen Forschergruppen viele Basisdaten insbesondere zur Ökologie, Physiologie und Physik des Fliegens und Schwimmens aber auch zur Stabilität beispielsweise der Gräser erarbeitet. Lebewesen überraschen immer wieder durch ihre "Biodiversität", ihre hochspezifischen Ausgestaltungen und Anpassungen.

  2. Aufnahme, Analyse und Visualisierung von Bewegungen nativer Herzklappen in-vitro

    NASA Astrophysics Data System (ADS)

    Weiß, Oliver; Friedl, Sven; Kondruweit, Markus; Wittenberg, Thomas

    Die hohe Zahl an Transplantationen von Herzklappen und viele nötige Re-Operationen machen eine detaillierte Analyse der Strömungen und Klappenbewegungen klinisch interessant. Ein neuer Ansatz ist hierbei der Einsatz von Hochgeschwindigkeitskameras um Bewegungsabl äufe der Herzklappen beobachten und auswerten zu können. Die hohen Datenraten erfordern allerdings eine möglichst automatisierte Analyse und möglichst komprimierte Darstellung des Schwingungsverhaltens. In dieser Arbeit wird ein Ansatz vorgestellt, bei dem Bewegungen nativer Herzklappen in-vitro aufgenommen, analysiert und kompakt visualisiert werden.

  3. Lambmeat colour values (HunterLab CIE and reflectance) are influenced by aperture size (5 mm v. 25 mm).

    PubMed

    Holman, Benjamin W B; Ponnampalam, Eric N; van de Ven, Remy J; Kerr, Matthew G; Hopkins, David L

    2015-02-01

    The effect of aperture size on the assessment of lamb meat colour values (L*, a*, b* and R630/580)was investigated. Two experiments using 2 HunterLab MiniScan colorimeters (large [25 mm] and small [5 mm] apertures) were conducted: 1) coloured tiles were measured and 2) unaged lamb (n = 65) m. longissimus lumborum (LL) and m. semimembranosus (SM) muscles were measured over 2.5 d under simulated retail display. For Experiment three, 2 different colorimeters were used on lamb (n = 36) LL aged for 6 weeks before measurement over 4 don simulated retail display. Coloured tile a* and b* values were unaffected by aperture size, but L* values and the R630/580 ratio were influenced by aperture size. The effect of aperture size on lamb meat colour measurements varied with display time and muscle type. The large aperture size generally provided the highest colorimetric values, and is recommended for measuring lamb meat colour.

  4. Formation of asteroids from mm-cm sized grains

    NASA Astrophysics Data System (ADS)

    Carrera, D.; Johansen, A.; Davies, M. B.

    2014-03-01

    Context. Asteroids and comets are intricately connected to life in the universe. Asteroids are the building blocks of terrestrial planets; water-rich asteroids and comets are likely to be the primary source of water for Earth's oceans and other volatiles (Morbidelli et al. 2000; Hartogh et al. 2011); and they may play role in mass extinctions. Yet, the formation of these objects is poorly understood. There is mounting evidence that the traditional picture of the formation of asteroids must be revised. The size distribution of asteroids is hard to reconcile with a traditional bottomup formation scenario. Instead, asteroids may form top-down, with large 100 - 1000 km sized objects forming first by the gravitational collapse of dense clumps of small particles. Experiments and simulations suggest that dust grains cannot grow to sizes larger than mm-cm in protoplanetary disks (Zsom et al. 2010). Also, primitive meteorites from the asteroid belt contain a large mass fraction in chondrules of sizes from 0.1 mm to a few mm. Hence, it is desirable to find a model for asteroid formation from mm-sized particles. Aims. In this work, we model the dynamics of mm-cm sized grains in dust-enriched inner regions of protoplanetary disks. We model the dust-gas interaction to determine whether dust grains of this size can form dense, self-gravitating clouds that can collapse to form asteroids. Methods. We perform shearing box simulations of the inner disk using the Pencil Code (Brandenburg & Dobler 2002). The simulations start with a Solar-type solids-to-gas ratio of 0.01 and we gradually increase the particle concentration. In a real protoplanetary disk, solid particles are expected to migrate from the outer regions and concentrate in the inner disk. Results. Our simulations show that mm-sized particles can form very dense clumps, driven by a run-away convergence in the radial-drift flow of these particles - this dynamic is known as the streaming instability (Youdin & Goodman 2005

  5. TNT particle size distributions from detonated 155-mm howitzer rounds.

    PubMed

    Taylor, Susan; Hewitt, Alan; Lever, James; Hayes, Charlotte; Perovich, Laura; Thorne, Phil; Daghlian, Chuck

    2004-04-01

    To achieve sustainable range management and avoid or minimize environmental contamination, the Army needs to know the amount of explosives deposited on ranges from different munitions and how these are degraded and transported under different geological and climatic conditions. The physical form of the deposited explosives has a bearing on this problem, yet the shapes and size distributions of the explosive particles remaining after detonations are not known. We collected residues from 8 high-order and 6 low-order non-tactical detonations of TNT-filled 155-mm rounds. We found significant variation in the amount of TNT scattered from the high-order detonations, ranging from 0.00001 to 2% of the TNT in the original shell. All low-order detonations scattered percent-level amounts of TNT. We imaged thousands of TNT particles and determined the size, mass and surface-area distributions of particles collected from one high-order and one low-order detonation. For the high-order detonation, particles smaller than 1 mm contribute most of the mass and surface area of the TNT scattered. For the low-order detonation, most of the scattered TNT mass was in the form of un-heated, centimeter-sized pieces whereas most of the surface area was again from particles smaller than 1 mm. We also observed that the large pieces of TNT disintegrate readily, giving rise to many smaller particles that can quickly dissolve. We suggest picking up the large pieces of TNT before they disintegrate to become point sources of contamination.

  6. Slow Slip Events on a 760 mm Long Granite Sample

    NASA Astrophysics Data System (ADS)

    Mclaskey, G.; Yamashita, F.

    2015-12-01

    We describe slow slip events and dynamic rupture events generated on a newly constructed large-scale biaxial friction apparatus at Cornell University that provide insights into the mechanisms of aseismic and seismic slip. We find that, under nominally similar experimental conditions, the 760 mm long granite sample sometimes slips in dynamic stick-slip events and sometimes relieves accumulated shear stress through slow slip events. To provide insights into this curious behavior and the underlying mechanisms, fault slip and shear stress are each measured at 8 locations along the 760 mm long fault. This allows us to map slow slip fronts and the nucleation and propagation of dynamic fault rupture. The granite sample is also instrumented with an array of piezoelectric sensors that are the laboratory equivalent of a seismic network. When the sample is loaded relatively slowly, at 0.03 MPa/s, slow slip occurs on large sections of the fault and the slow slipping region soon expands to the sample boundary. In this case, stress is released in a slow slip event with peak slip velocities < 2 mm/s. Alternatively, when one end of the sample is loaded rapidly (4 MPa/s), or the sample is allowed to heal in stationary contact for a few minutes, slow slip initiates near the load point and accelerates to slip velocities exceeding 200 mm/s before the slow slipping region expands all the way to the sample boundary. This produces a dynamic slip event (stick-slip). The dynamic slip events radiate seismic waves equivalent to a M = -2.5 earthquake. In contrast, the laboratory-generated slow slip events are predominantly aseismic and produce only bursts of tiny and discrete seismic events (M = -6) reminiscent of swarms of microseismicity. The experiments illustrate how a single fault can slide slowly and aseismically or rapidly and dynamically depending on stress state and loading conditions. We compare the behavior observed on this Cornell apparatus to the behavior of other large

  7. Gas Analysis by Fourier Transform Mm-Wave Spectroscopy

    NASA Astrophysics Data System (ADS)

    Harris, Brent J.; Steber, Amanda L.; Lehmann, Kevin K.; Pate, Brooks H.

    2013-06-01

    Molecular rotational spectroscopy of low pressure, room temperature gases offers high chemical selectivity and sensitivity with the potential for a wide range of applications in gas analysis. A strength of the technique is the potential to identify molecules that have not been previously studied by rotational spectroscopy by comparing experimental results to predictions of the spectroscopic parameters from quantum chemistry -6 so called library-free detection. The development of Fourier transform mm-wave spectrometers using high peak power (30 mW) active multiplier chain mm-wave sources brings new measurement capabilities to the analysis of complex gas mixtures. Strategies for gas analysis based on high-throughput mm-wave spectroscopy and arbitrary waveform generator driven mm-wave sources are described. Several new measurement capabilities come from the intrinsic time-domain measurement technique. High-sensitivity double-resonance measurements can be performed to speed the analysis of a complex gas sample containing several species. This technique uses a "pi-pulse" to selectively invert the population of two selected rotational energy levels and the effect of this excitation pulse on all other transitions in the spectrometer operating range is monitored using segmented chirped-pulse Fourier transform spectroscopy. This method can lead to automated determination of the molecular rotational constants. Rapid pulse duration scan experiments can be used to estimate the magnitude and direction of the dipole moment of the molecule from an unknown spectrum. Coherent pulse echo experiments, using the traditional Hahn sequence or two-color population recovery methods, can be used to determine the collisional relaxation rate of the unknown molecule. This rate determination improves the ability to estimate the mass of the unknown molecule from the determination of the Doppler dephasing rate. By performing a suite of automated, high-throughput measurements, there is the

  8. A 4MM-Wave composite mode multimode conical feedhorn

    NASA Astrophysics Data System (ADS)

    Lin, Zhisheng; Du, Zhengmi; Chen, Shener

    1996-10-01

    A 4MM-Wave composite mode multimode conical feedhorn has been developed. Its mode-ratios are calculated and its formulas of the radiation patterns are derived. The measurement results of one and two dimension radiation patterns, measured by the automatic measurement system which we had researched, and the properties of band width and sidelobe are given. Theoretical analyses and measurements show that at the centre frequency 69.1GHZ, down to -23dB, the radiation pattern is rotationally symmetric, in this range there is not any sidelobe existing, the band width is 4.5 GHZ. The multimode feedhorn is thus of certain practical using value.

  9. Advanced accelerator and mm-wave structure research at LANL

    SciTech Connect

    Simakov, Evgenya Ivanovna

    2016-06-22

    This document outlines acceleration projects and mm-wave structure research performed at LANL. The motivation for PBG research is described first, with reference to couplers for superconducting accelerators and structures for room-temperature accelerators and W-band TWTs. These topics are then taken up in greater detail: PBG structures and the MIT PBG accelerator; SRF PBG cavities at LANL; X-band PBG cavities at LANL; and W-band PBG TWT at LANL. The presentation concludes by describing other advanced accelerator projects: beam shaping with an Emittance Exchanger, diamond field emitter array cathodes, and additive manufacturing of novel accelerator structures.

  10. Maps based on 53 GHz (5.7 mm wavelength)

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Maps based on 53 GHz (5.7 mm wavelength) observations made with the DMR over the entire 4-year mission (top) on a scale from 0 - 4 K, showing the near-uniformity of the CMB brightness, (middle) on a scale intended to enhance the contrast due to the dipole described in the slide 19 caption, and (bottom) following subtraction of the dipole component. Emission from the Milky Way Galaxy is evident in the bottom image. See slide 19 caption for information about map smoothing and projection.

  11. Over 1.0 mm-long boron nitride nanotubes

    NASA Astrophysics Data System (ADS)

    Chen, Hua; Chen, Ying; Liu, Yun; Fu, Lan; Huang, Cheng; Llewellyn, David

    2008-09-01

    Over 1.0 mm boron nitride nanotubes (BNNTs) were successfully synthesized by an optimized ball milling and annealing method. The annealing temperature of 1100 °C is crucial for the growth of the long BNNTs because at this temperature there is a fast nitrogen dissolution rate in Fe and the B/N ratio in Fe is 1. Such long BNNTs enable a reliable single tube configuration for electrical property characterization and consequently the average resistivity of the long BNNTs is determined to be 7.1 ± 0.9 × 10 4 Ω cm. Therefore, these BNNTs are promising insulators for three dimensional microelectromechanical system.

  12. Dynamic impact analysis of the M1 105mm projectile

    SciTech Connect

    Walls, J.C.; Webb, D.S.

    1993-06-01

    Evaluation of the effects of [open quotes]rough-handling[close quotes]-induced stresses in the nose region of a 105mm artillery projectile was performed to determine if these stresses could have contributed to the premature explosion of a projectile during a Desert Shield training mission of the 101st Army Airborne in Saudi Arabia. The rough-handling evaluations were simulated by dynamic impact analysis. It was concluded that the combined residual stress and dynamic impact-induced stress would not be of sufficient magnitude to cause cracking of the projectile in the nose region.

  13. Dynamic impact analysis of the M1 105mm projectile

    SciTech Connect

    Walls, J.C.; Webb, D.S.

    1993-06-01

    Evaluation of the effects of {open_quotes}rough-handling{close_quotes}-induced stresses in the nose region of a 105mm artillery projectile was performed to determine if these stresses could have contributed to the premature explosion of a projectile during a Desert Shield training mission of the 101st Army Airborne in Saudi Arabia. The rough-handling evaluations were simulated by dynamic impact analysis. It was concluded that the combined residual stress and dynamic impact-induced stress would not be of sufficient magnitude to cause cracking of the projectile in the nose region.

  14. QM/MM Molecular Dynamics Studies of Metal Binding Proteins

    PubMed Central

    Vidossich, Pietro; Magistrato, Alessandra

    2014-01-01

    Mixed quantum-classical (quantum mechanical/molecular mechanical (QM/MM)) simulations have strongly contributed to providing insights into the understanding of several structural and mechanistic aspects of biological molecules. They played a particularly important role in metal binding proteins, where the electronic effects of transition metals have to be explicitly taken into account for the correct representation of the underlying biochemical process. In this review, after a brief description of the basic concepts of the QM/MM method, we provide an overview of its capabilities using selected examples taken from our work. Specifically, we will focus on heme peroxidases, metallo-β-lactamases, α-synuclein and ligase ribozymes to show how this approach is capable of describing the catalytic and/or structural role played by transition (Fe, Zn or Cu) and main group (Mg) metals. Applications will reveal how metal ions influence the formation and reduction of high redox intermediates in catalytic cycles and enhance drug metabolism, amyloidogenic aggregate formation and nucleic acid synthesis. In turn, it will become manifest that the protein frame directs and modulates the properties and reactivity of the metal ions. PMID:25006697

  15. Resonant biaxial 7-mm MEMS mirror for omnidirectional scanning

    NASA Astrophysics Data System (ADS)

    Hofmann, U.; Aikio, M.; Janes, J.; Senger, F.; Stenchly, V.; Weiss, M.; Quenzer, H.-J.; Wagner, B.; Benecke, W.

    2013-03-01

    Low-cost automotive laser scanners for environment perception are needed to enable the integration of advanced driver assistant systems (ADAS) into all automotive vehicle segments, a key to reducing the number of traffic accidents on roads. An omnidirectional 360 degree laser scanning concept has been developed based on combination of an omnidirectional lens and a biaxial large aperture MEMS mirror. This omnidirectional scanning concept is the core of a small sized low-cost time-of-flight based range sensor development. This paper describes concept, design, fabrication and first measurement results of a resonant biaxial 7mm gimbal-less MEMS mirror that is electrostatically actuated by stacked vertical comb drives. Identical frequencies of the two resonant axes are necessary to enable the required circle scanning capability. A tripod suspension was chosen since it allows minimizing the frequency splitting of the two resonant axes. Low mirror curvature is achieved by a thickness of the mirror of more than 500 μm. Hermetic wafer level vacuum packaging of such large mirrors based on multiple wafer bonding has been developed to enable to achieve a large mechanical tilt angle of +/- 6.5 degrees in each axis. The 7mm-MEMS mirror demonstrates large angle circular scanning at 1.5kHz.

  16. Using 70-mm aerial photography to identify rangeland sites

    NASA Technical Reports Server (NTRS)

    Everitt, J. H.; Gerbermann, A. H.; Alaniz, M. A.; Bowen, R. L.

    1980-01-01

    A south Texas rangeland area was used as a study site to test the use of microdensitometry on 70-mm color-infrared and black-and-white photographs (scale 1:19,000) for distinguishing among 11 range sites (two brushland, seven grassland, two barren land) during the winter (February), spring (May), and summer (August) of 1976. Color-infrared photographs were also taken at a scale of 1:42,000 for the summer date. Film optical density readings were made on one color-infrared film with white light only. The best separations among density readings for all range sites were obtained using white light exposed on color-infrared film in the summer when vegetation was at peak foliage development. Results from this study indicate that 70-mm aerial color-infrared photography at a scale of 1:19,000 or 1:42,000 has good potential for identifying range sites in large and inaccessible areas, and could be a useful tool for range management.

  17. Robotic QM/MM-driven maturation of antibody combining sites

    PubMed Central

    Smirnov, Ivan V.; Golovin, Andrey V.; Chatziefthimiou, Spyros D.; Stepanova, Anastasiya V.; Peng, Yingjie; Zolotareva, Olga I.; Belogurov, Alexey A.; Kurkova, Inna N.; Ponomarenko, Natalie A.; Wilmanns, Matthias; Blackburn, G. Michael; Gabibov, Alexander G.; Lerner, Richard A.

    2016-01-01

    In vitro selection of antibodies from large repertoires of immunoglobulin (Ig) combining sites using combinatorial libraries is a powerful tool, with great potential for generating in vivo scavengers for toxins. However, addition of a maturation function is necessary to enable these selected antibodies to more closely mimic the full mammalian immune response. We approached this goal using quantum mechanics/molecular mechanics (QM/MM) calculations to achieve maturation in silico. We preselected A17, an Ig template, from a naïve library for its ability to disarm a toxic pesticide related to organophosphorus nerve agents. Virtual screening of 167,538 robotically generated mutants identified an optimum single point mutation, which experimentally boosted wild-type Ig scavenger performance by 170-fold. We validated the QM/MM predictions via kinetic analysis and crystal structures of mutant apo-A17 and covalently modified Ig, thereby identifying the displacement of one water molecule by an arginine as delivering this catalysis. PMID:27774510

  18. Hinderniserkennung und -verfolgung mit einer PMD-kamera im automobil

    NASA Astrophysics Data System (ADS)

    Schamm, Thomas; Vacek, Stefan; Natroshvilli, Koba; Marius Zöllner, J.; Dillmann, Rüdiger

    Die Detektion von Hindernissen vor dem Automobil ist eine Hauptanforderung an moderne Fahrerassistenzsysteme (FAS). In dieser Arbeit wird ein System vorgestellt, das mit Hilfe einer PMDKamera (Photomischdetektor) Hindernisse auf der Fahrspur erkennt und deren relevante Parameter bestimmt. Durch die PMD-Kamera werden zunächst 3D-Tiefenbilder der Fahrzeugumwelt generiert. Nach einem initialen Filterprozess werden im Tiefenbild mit Hilfe eines Bereichswachstumsverfahrens Hindernisse gesucht. Zur Stabilisierung des Verfahrens und zur Parameterberechnung wird ein Kaiman Filter eingesetzt. Das Ergebnis ist eine Liste aller Hindernisse im Fahrbereich des Automobils.

  19. Terror mit Atomwaffen: reale Gefahr? Nukleare und Radiologische Waffen

    NASA Astrophysics Data System (ADS)

    Harigel, Gert G.

    2006-01-01

    Können Terroristen sich nukleare Massenvernichtungswaffen beschaffen? Dazu müssten sie ausreichende Mengen an waffenfähigem, spaltbarem Material stehlen. Selbst der Bau einer primitiven Atombombe erfordert einen hohen technischen Aufwand und Spezialisten. Wahrscheinlicher ist deshalb der Diebstahl einer kleinen taktischen Kernwaffe. Alternativ könnten Terroristen sich radioaktives Material aus zivilen Quellen beschaffen und daraus eine Schmutzige Bombe bauen. Eine solche radiologische Waffe wäre keine echte Massenvernichtungswaffe, doch ihre psychologische Wirkung könnte stark sein. Das macht sie für Terroristen attraktiv, weswegen diese Gefahr ernst genommen werden muss.

  20. Reflexionseigenschaften von Windenergieanlagen im Funkfeld von Funknavigations- und Radarsystemen

    NASA Astrophysics Data System (ADS)

    Sandmann, S.; Divanbeigi, S.; Garbe, H.

    2015-11-01

    Die hier behandelte Untersuchung befasst sich mit den Störungen des elektrischen Feldes einer Doppler Very High Frequency Omnidirectional Radio Range Navigationsanlage (DVOR) in der Gegenwart von Windenergieanlagen (WEA). Hierfür wird die Feldstärke auf 25 konzentrischen Kreisbahnen, sog. Orbit Flights verschiedener Höhen und mit verschiedenen Radien rund um die DVOR-Anlage numerisch simuliert. Insbesondere werden die Einflüsse diverser Parameter der WEA wie deren Anzahl, Position, Rotorwinkel, Turmhöhe und Rotordurchmesser auf die Feldverteilung herausgestellt, sowie die Anwendbarkeit der Simulationsmethode Physical Optics (PO) durch Vergleich der Simulationsergebnisse mit denen der Multi Level Fast Multipol Method (MLFMM) untersucht.

  1. A densitometric analysis of commercial 35mm films

    NASA Astrophysics Data System (ADS)

    Hammond, Ernest C., Jr.; Ruffin, Christopher, III

    IIaO films have been subjected to various sensitometric tests. The have included thermal and aging effects and reciprocity failure studies. In order to compare the special IIaO film with popular brands of 35 mm films and their possible use in astrophotography, Agfa, Fuji and Kodak print and slide formats, as well as black and white and color formats, were subjected to sensitometric, as well as densitometric analysis. A scanning electron microscope was used to analyze grain structure size, and shape as a function of both speed and brand. Preliminary analysis of the grain structure using an ISI-SS40 scanning electron microscope indicates that the grain sizes for darker densities are much larger than the grain size for lighter densities. Researchers analyze the scanning electron microscope findings of the various grains versus densities as well as enhancement of the grains, using the IP-8500 Digital Image Processor.

  2. Walk through screening with multistatic mmW technology

    NASA Astrophysics Data System (ADS)

    Gumbmann, Frank; Ahmed, Sherif Sayed

    2016-10-01

    Active imaging systems for security screening at the airport or other checkpoints have proven to offer good results. Present systems require a specific position and posture,13 or a specific movement2 of the passenger in front of the imaging system. Walk Through Systems (WTS) which screen the passenger while passing the imaging system or a screening hallway would be more pleasant for the passenger and would result in a great improvement in the throughput. Furthermore the detection performance could be enhanced since possible threats are visible from different perspectives and could be tracked within different frames. The combination of all frames is equivalent to a full illumination of the passenger. This paper presents the concept of a WTS basing on a multistatic imaging system in the mmW range. The benefit is that the technology of existing portals can we reused and updated to a WTS. First results are demonstrated with an experimental system.

  3. Quantum Phase Slips in 6 mm Long Niobium Nanowire.

    PubMed

    Zhao, Weiwei; Liu, Xin; Chan, M H W

    2016-02-10

    Transport measurements were made to study the superconducting transition of four 6 mm long niobium nanowires with different cross-sectional dimensions. A low-temperature residual resistance tail measured with an excitation current of 5 nA is found in the thinnest wire down to 50 mK or 7.7% of Tc of Nb. The functional form of the residual resistance is consistent with quantum phase slip (QPS) processes. Resistance measured at high bias excitation current switches among many discrete values that are well below the normal state resistance. These discrete resistance values as a function of temperature fall into several parallel curves all showing QPS-like decay in the low temperature limit similar to that found at low current. The coexistence of QPS-like resistance tails and resistance jumps found in the same wire unifies results from previous experiments where these two distinct sets of evidence for QPS are exclusive of each other.

  4. Developing adaptive QM/MM computer simulations for electrochemistry.

    PubMed

    Dohm, Sebastian; Spohr, Eckhard; Korth, Martin

    2017-01-05

    We report the development of adaptive QM/MM computer simulations for electrochemistry, providing public access to all sources via the free and open source software development model. We present a modular workflow-based MD simulation code as a platform for algorithms for partitioning space into different regions, which can be treated at different levels of theory on a per-timestep basis. Currently implemented algorithms focus on targeting molecules and their solvation layers relevant to electrochemistry. Instead of using built-in forcefields and quantum mechanical methods, the code features a universal interface, which allows for extension to a range of external forcefield programs and programs for quantum mechanical calculations, thus enabling the user to readily implement interfaces to those programs. The purpose of this article is to describe our codes and illustrate its usage. © 2016 Wiley Periodicals, Inc.

  5. Magnetic design of a 14 mm period prototype superconducting undulator

    NASA Astrophysics Data System (ADS)

    Gehlot, Mona; Mishra, G.; Trillaud, Frederic; Sharma, Geetanjali

    2017-02-01

    In this paper we report the design of a 14 mm period prototype superconducting undulator that is under fabrication at Insertion Device Development Laboratory (IDDL) at Devi Ahilya Vishwavidyalaya, Indore, India. The field computations are made in RADIA and results are presented in an analytical form for computation of the on axis field and the field on the surface of the coil. On the basis of the findings, a best fit is presented for the model to calculate the field dependence on the gap and the current density. The fit is compared with Moser-Rossmanith formula proposed earlier to predict the magnetic flux density of a superconducting undulator. The field mapping is used to calculate the field integrals and its dependence on gap and current densities as well.

  6. Phase correlator reduces mm-wave radar cost

    NASA Astrophysics Data System (ADS)

    Weiss, R., Sr.; Hobbs, P.; Locatelli, J.

    1986-03-01

    A technique involving the IC storage of magnetron phase for reference has been developed to make possible the use of the low-cost efficient magnetron in obtaining phase coherent signals for pulse Doppler radar. In the new external coherence method, the recorded random midpulse-region phase is compared with the frequency of the echo allowing Doppler information, free of phase noise, to be extracted. The gated magnetron was tested at Ka-band in a 35-GHz radar, and good agreement with the CP-4 5.5 GHz radar was shown. With good accuracy down to 10 cm/s, the present system, especially in the mm-wave region, has important applications to meteorological and military radar.

  7. A densitometric analysis of commercial 35mm films

    NASA Technical Reports Server (NTRS)

    Hammond, Ernest C., Jr.; Ruffin, Christopher, III

    1989-01-01

    IIaO films have been subjected to various sensitometric tests. The have included thermal and aging effects and reciprocity failure studies. In order to compare the special IIaO film with popular brands of 35 mm films and their possible use in astrophotography, Agfa, Fuji and Kodak print and slide formats, as well as black and white and color formats, were subjected to sensitometric, as well as densitometric analysis. A scanning electron microscope was used to analyze grain structure size, and shape as a function of both speed and brand. Preliminary analysis of the grain structure using an ISI-SS40 scanning electron microscope indicates that the grain sizes for darker densities are much larger than the grain size for lighter densities. Researchers analyze the scanning electron microscope findings of the various grains versus densities as well as enhancement of the grains, using the IP-8500 Digital Image Processor.

  8. Lunar polarization studies at 3.1 mm wavelength

    NASA Technical Reports Server (NTRS)

    White, T. L.; Cogdell, J. R.

    1973-01-01

    Observations of the distribution of linearly polarized lunar thermal emission were made at a wavelength of 3.1 mm with The University of Texas 4.88 m parabolic reflector (0.042 deg HPBW). A shadow corrected, rough surface, thermal emission model for a homogeneous moon was least-squares-fitted to the polarization data. Results indicate an effective lunar dielectric constant of 1.34 plus or minus 0.04 with surface roughness characterized by a standard deviation of 17 (plus or minus 5) deg for surface slopes with a normal probability density, independent of lunar phase. A comparison of these results with published values at other wavelengths suggests that the effective lunar dielectric constant, as obtained by lunar emission measurements, decreases with decreasing wavelength of observation. This wavelength dependence may be interpreted in terms of an inhomogeneous surface and/or a surface that possesses intermediate scale surface roughness.

  9. The Apollo 15 coarse fines (4-10 mm)

    NASA Technical Reports Server (NTRS)

    Ryder, Graham; Sherman, Sarah Bean

    1989-01-01

    A new catalog of the Apollo 15 coarse fines particles is presented. Powell's macroscopic descriptions, resulting from his 1972 particle by particle binocular examination of all of the Apollo 15 4 to 10 mm fines samples, are retained. His groupings are also retained, but petrographic, chemical, and other data from later analyses are incorporated into this catalog to better characterize individual particles and describe the groups. A large number of particles have no characterization beyond that done by Powell. Complete descriptions of the particles and all known references are provided. The catalog is intended for anyone interested in the rock types collected by Dave Scott and Jim Irwin in the Hadley-Appenine region, and particularly for researchers requiring sample allocations.

  10. Expulsion of the intrauterine devices Lippes loop size 30 mm.

    PubMed

    el-Zeneiny, A H; Ammar, A R; Badawi, S Z

    1969-01-01

    To determine the factors controlling IUD expulsion (Lippes loop 30 mm), Cairo's Ain-Shams Birth Control Clinic investigated 25 women with regard to the following: 1) detailed obstetric history; 2) hystergram; 3) Lipiodol hysterosalpinography (postmenstrual cases); 4) measurement of uterine cavity; 5) dilation (Hegar's No. 8) to determine internal os integrity. In 40% of the expulsions congenital abnormalities of the uterus was found while another 40% revealed a patulous internal os. In septate and arcuate uteruses, continuous pressure on the upper part of the loop found to cause expulsion. Uterine contractions occurring during menstruation were also seen to increase chances of expulsion, particularly in cases of patulous internal os. In 20% of the cases, no anomoly was detected and expulsion was thought to have resulted from faulty insertion or irrigation of the uterus by a foreign body.

  11. Assembly of mm-scale macrobridges with carbon nanotube bundles

    NASA Astrophysics Data System (ADS)

    Cao, Anyuan; Ajayan, P. M.; Ramanath, G.

    2003-07-01

    We report a chemical vapor deposition method for in situ bridging of mm-scale metal-contact patterns with bundles of multiwalled carbon nanotubes. The nanotube bundles synthesized from a hexane-ferrocene-thiophene mixture have a diameter of <50 μm and lengths up to millimeters, typically consisting of tens to hundreds of aligned nanotubes. These bundles are transported to the downstream end of the furnace, where they are captured by relief patterns of metal-contact tips. We can control the orientation and length of the nanotube bridges by preorganizing the metal tips to receive the bundles. This method is amenable to both scaling up, e.g., to create large-area arrays of nanotubes with contact electrodes, as well as scaling down, e.g., to bridge closely spaced contact structures.

  12. Modelling and performance of Nb SIS mixers in the 1.3 mm and 0.8 mm bands

    NASA Technical Reports Server (NTRS)

    Karpov, A.; Carter, M.; Lazareff, B.; Billon-Pierron, D.; Gundlach, K. H.

    1992-01-01

    We describe the modeling and subsequent improvements of SIS waveguide mixers for the 200-270 and 330-370 GHz bands (Blundell, Carter, and Gundlach 1988, Carter et al 1991). These mixers are constructed for use in receivers on IRAM radiotelescopes on Pico Veleta (Spain, Sierra Nevada) and Plateau de Bure (French Alps), and must meet specific requirements. The standard reduced height waveguide structure with suspended stripline is first analyzed and a model is validated through comparison with scale model and working scale measurements. In the first step, the intrinsic limitations of the standard mixer structure are identified, and the parameters are optimized bearing in mind the radioastronomical applications. In the second step, inductive tuning of the junctions is introduced and optimized for minimum noise and maximum bandwidth. In the 1.3 mm band, a DSB receiver temperature of less than 110 K (minimum 80 K) is measured from 180 through 260 GHz. In the 0.8 mm band, a DSB receiver temperature of less than 250 K (minimum 175 K) is obtained between 325 and 355 GHz. All these results are obtained with room-temperature optics and a 4 GHz IF chain having a 500 MHz bandwidth and a noise temperature of 14 K.

  13. Modelling and performance of Nb SIS mixers in the 1.3 mm and 0.8 mm bands

    NASA Astrophysics Data System (ADS)

    Karpov, A.; Carter, M.; Lazareff, B.; Billon-Pierron, D.; Gundlach, K. H.

    We describe the modeling and subsequent improvements of SIS waveguide mixers for the 200-270 and 330-370 GHz bands (Blundell, Carter, and Gundlach 1988, Carter et al 1991). These mixers are constructed for use in receivers on IRAM radiotelescopes on Pico Veleta (Spain, Sierra Nevada) and Plateau de Bure (French Alps), and must meet specific requirements. The standard reduced height waveguide structure with suspended stripline is first analyzed and a model is validated through comparison with scale model and working scale measurements. In the first step, the intrinsic limitations of the standard mixer structure are identified, and the parameters are optimized bearing in mind the radioastronomical applications. In the second step, inductive tuning of the junctions is introduced and optimized for minimum noise and maximum bandwidth. In the 1.3 mm band, a DSB receiver temperature of less than 110 K (minimum 80 K) is measured from 180 through 260 GHz. In the 0.8 mm band, a DSB receiver temperature of less than 250 K (minimum 175 K) is obtained between 325 and 355 GHz. All these results are obtained with room-temperature optics and a 4 GHz IF chain having a 500 MHz bandwidth and a noise temperature of 14 K.

  14. Diorganostyrylzinndiorganophosphine und Ihre Tricarbonylnickelkomplexe (Diorganostyryltin Phosphines and its Tricarbonylnickel Complexes).

    DTIC Science & Technology

    1979-12-03

    Umkristallisieren aus Pentan/Benzol/Toluol gereinigt werden konnen; IVb zeigt bereits ab 0°C Polym erisationserschei- nungen. Vb und VIb werden als heligelbe...einem Rar.ger Engeneering M6ssbauer Spectrometer benutzt wurde. in C 6 D 6c) die Ha lbwertsbreiten wurden als glei~h vorausgesetzt , um dos Si gnal als

  15. Increasing Pragmatic Awareness: Die Vagheit der Sprache "und so"

    ERIC Educational Resources Information Center

    Overstreet, Maryann; Tran, Jennie; Zietze, Sylvia

    2006-01-01

    This article presents a description of some pragmatic expressions ("oder so," "und so," "oder wie") rarely found in textbooks, but common in everyday conversation. Though often treated as vague or superfluous, these expressions perform important functions in interpersonal communication. Focusing on these easily identifiable phrases can help…

  16. Denken in Wertschöpfung und Verschwendung

    NASA Astrophysics Data System (ADS)

    Bergmann, Lars; Lacker, Michael

    Eine Antwort auf die Frage welche Arbeitsschritte, Aktivitäten und Prozesse als wertschöpfend betrachtet werden können, erhält man durch die Überlegung, ob der Kunde bereit ist dafür zu zahlen. Kunden sind sicher bereit dafür zu zahlen, dass z.B. die Räder an ihrem neuen PKW sicher montiert sind. Die im Unternehmen notwendigen logistischen Prozesse, die die Räder zu ihrem Montageort transportieren, sind aus Sicht des Kunden dagegen mit keinem Wert verbunden. Insofern ist er nicht bereit dafür zu zahlen und sämtliche internen logistischen Aktivitäten sind entsprechend nicht wertschöpfend. Verschwendung bzw. nicht wertschöpfende Arbeit umfasst alle Aktivitäten, Tätigkeiten und Prozesse, die Zeit, Ressourcen und/oder Raum kosten, aber nicht zur Erfüllung der Kundenanforderungen beitragen. Verschwendung ist damit der Teil der Arbeit, für den der Kunde nicht zahlt, z.B. den internen Transport von Bauteilen zum Montageort.

  17. Experimental characteristics of a high-gain free-electron laser amplifier operating at 8-mm and 2-mm wavelengths

    SciTech Connect

    Throop, A.L.; Orzechowski, T.J.; Anderson, B.R.; Chambers, F.W.; Clark, J.C.; Fawley, W.M.; Jong, R.A.; Halbach, K.; Hopkins, D.B.; Sessler, A.M.

    1987-06-08

    The Electron Laser Facility (ELF) at the Lawrence Livermore National Laboratory (LLNL) uses a high-current induction linac (3.5 MeV, 1000 A), in conjunction with a pulsed electromagnetic wiggler (4.0 M, 4000 G), to operate a free electron laser (FEL) that produces intense radiation in the microwave regime (2 to 8 mm). ELF is a high-gain, single-pass amplifier, using a commercial microwave source as an oscillator input (200 W-50 kW). Previous experiments at 35 GHz produced exponential gains of 40 dB/m, peak powers exceeding 1 GW, and beam-to-rf conversion efficiencies of 34%. Recent experiments at 140 GHz have demonstrated exponential gains of 22 dB/m, peak powers exceeding 50 MW, and total gains of 65 dB. In this paper, we describe the experimental results at these two frequencies and compare then with the predictions of simulation codes.

  18. GDx-MM: An imaging Mueller matrix retinal polarimeter

    NASA Astrophysics Data System (ADS)

    Twietmeyer, Karen Marie

    2007-12-01

    Retinal diseases are a major cause of blindness worldwide. Although widely studied, disease mechanisms are not completely understood, and diagnostic tests may not detect disease early enough for timely intervention. The goal of this research is to contribute to research for more sensitive diagnostic tests that might use the interaction of polarized light with retinal tissue to detect subtle changes in the microstructure. This dissertation describes the GDx-MM, a scanning laser polarimeter which measures a complete 16-element Mueller matrix image of the retina. This full polarization signature may provide new comparative information on the structure of healthy and diseased retinal tissue by highlighting depolarizing structures as well as structures with varying magnitudes and orientations of retardance and diattenuation. The three major components of this dissertation are: (1) Development of methods for polarimeter optimization and error analysis; (2) Design, optimization, assembly, calibration, and validation of the GDx-MM polarimeter; and (3) Analysis of data for several human subjects. Development involved modifications to a Laser Diagnostics GDx, a commercially available scanning laser ophthalmoscope with incomplete polarization capability. Modifications included installation of polarization components, development of a data acquisition system, and implementation of algorithms to convert raw data into polarization parameter images. Optimization involved visualization of polarimeter state trajectories on the Poincare sphere and a condition number analysis of the instrument matrix. Retinal images are collected non-invasively at 20 mum resolution over a 15° visual field in four seconds. Validation of the polarimeter demonstrates a polarimetric measurement accuracy of approximately +/- 5%. Retinal polarization data was collected on normal human subjects at the University of Arizona and at Indiana University School of Optometry. Calculated polarization parameter

  19. Mapping protein electron transfer pathways with QM/MM methods

    PubMed Central

    Guallar, Victor; Wallrapp, Frank

    2008-01-01

    Mixed quantum mechanics/molecular mechanics (QM/MM) methods offer a valuable computational tool for understanding the electron transfer pathway in protein–substrate interactions and protein–protein complexes. These hybrid methods are capable of solving the Schrödinger equation on a small subset of the protein, the quantum region, describing its electronic structure under the polarization effects of the remainder of the protein. By selectively turning on and off different residues in the quantum region, we are able to obtain the electron pathway for short- and large-range interactions. Here, we summarize recent studies involving the protein–substrate interaction in cytochrome P450 camphor, ascorbate peroxidase and cytochrome c peroxidase, and propose a novel approach for the long-range protein–protein electron transfer. The results on ascorbate peroxidase and cytochrome c peroxidase reveal the importance of the propionate groups in the electron transfer pathway. The long-range protein–protein electron transfer has been studied on the cytochrome c peroxidase–cytochrome c complex. The results indicate the importance of Phe82 and Cys81 on cytochrome c, and of Asn196, Ala194, Ala176 and His175 on cytochrome c peroxidase. PMID:18445553

  20. Digital Frequency Domain Multiplexer for mm-Wavelength Telescopes

    SciTech Connect

    Spieler, Helmuth G; Dobbs, Matt; Bissonnette, Eric; Spieler, Helmuth G.

    2007-07-23

    An FPGA based digital signal processing (DSP) system for biasing and reading out multiplexed bolometric detectors for mm-wavelength telescopes is presented. This readout system is being deployed for balloon-borne and ground based cosmology experiments with the primary goal of measuring the signature of inflation with the Cosmic Microwave Background Radiation. The system consists of analog superconducting electronics running at 250 mK and 4 K, coupled to digital room temperature backend electronics described here. The digital electronics perform the real time functionality with DSP algorithms implemented in firmware. A soft embedded processor provides all of the slow housekeeping control and communications. Each board in the system synthesizes multi-frequency combs of 8 to 32 carriers in the MHz band to bias the detectors. After the carriers have been modulated with the sky-signal by the detectors, the same boards digitize the comb directly. The carriers are mixed down to base-band and low pass filtered. The signal bandwidth of 0.050Hz-100 Hz places extreme requirements on stability and requires powerful filtering techniques to recover the sky-signal from the MHz carriers.

  1. rf breakdown tests of mm-wave metallic accelerating structures

    NASA Astrophysics Data System (ADS)

    Dal Forno, Massimo; Dolgashev, Valery; Bowden, Gordon; Clarke, Christine; Hogan, Mark; McCormick, Doug; Novokhatski, Alexander; Spataro, Bruno; Weathersby, Stephen; Tantawi, Sami G.

    2016-01-01

    We are exploring the physics and frequency-scaling of vacuum rf breakdowns at sub-THz frequencies. We present the experimental results of rf tests performed in metallic mm-wave accelerating structures. These experiments were carried out at the facility for advanced accelerator experimental tests (FACET) at the SLAC National Accelerator Laboratory. The rf fields were excited by the FACET ultrarelativistic electron beam. We compared the performances of metal structures made with copper and stainless steel. The rf frequency of the fundamental accelerating mode, propagating in the structures at the speed of light, varies from 115 to 140 GHz. The traveling wave structures are 0.1 m long and composed of 125 coupled cavities each. We determined the peak electric field and pulse length where the structures were not damaged by rf breakdowns. We calculated the electric and magnetic field correlated with the rf breakdowns using the FACET bunch parameters. The wakefields were calculated by a frequency domain method using periodic eigensolutions. Such a method takes into account wall losses and is applicable to a large variety of geometries. The maximum achieved accelerating gradient is 0.3 GV /m with a peak surface electric field of 1.5 GV /m and a pulse length of about 2.4 ns.

  2. The LMT Galaxies' 3 mm Spectroscopic Survey: First Results

    NASA Astrophysics Data System (ADS)

    Rosa González, D.; Schloerb, P.; Vega, O.; Hunt, L.; Narayanan, G.; Calzetti, D.; Yun, M.; Terlevich, E.; Terlevich, R.; Mayya, Y. D.; Chávez, M.; Montaña, A.; Pérez García, A. M.

    2014-09-01

    The molecular phase of the interstellar medium (ISM) in galaxies offers fundamental insight for understanding star-formation processes and how stellar feedback affects the nuclear activity of certain galaxies. We present here Large Millimeter Telescope spectra obtained with the Redshift Search Receiver, a spectrograph that covers simultaneously the 3 mm band from 74 to 111 GHz with a spectral resolution of around 100 km/s. Our selected galaxies, have been detected previously in HCN, and have different degrees of nuclear activity — one normal galaxy (NGC 6946), the starburst prototype (M82) and two %ultraluminous infrared galaxies (ULIRGs, IRAS 17208-0014 and Mrk 231). We plotted our data in the HCO+/HCN vs. HCN/13CO diagnostic diagram finding that NGC 6946 and M82 are located close to other normal galaxies; and that both IRAS 17208-0014 and Mrk 231 are close to the position of the well known ULIRG Arp 220 reported by Snell et al. (2011). We found that in Mrk 231 - a galaxy with a well known active galactic nucleus - the HCO+/HCN ratio is similar to the ratio observed in normal galaxies.

  3. 100 mm dynamic stencils pattern sub-micrometre structures.

    PubMed

    Savu, Veronica; Xie, Shenqi; Brugger, Juergen

    2011-07-01

    Dynamic stencil lithography uses a moving shadow-mask to draw patterns by having directionally evaporated material deposited through the stencil apertures onto the substrate. Sub-micrometre, two-dimensional patterning is demonstrated at full 100 mm wafer scale, with two examples emphasizing this technique's unique features. Structures having a width-modulated height below a certain aperture size are fabricated by moving the stencil according to a two-dimensional trajectory. Variable-period gratings are obtained by translating a row of apertures at different orientations with respect to the row's axis. Despite the long deposition sequences one could envision for a stencil in dynamic mode, the apertures' active life-time in the sub-micrometre domain remains limited by the material's accretion on the membrane, resulting in the eventual clogging of the openings. A novel solution to this problem containing a micro-heater embedded in the membrane is described and its effectiveness in preventing material from clogging the apertures is demonstrated.

  4. COSMOG: Cosmology Oriented Sub-mm Modeling of Galactic Foregrounds

    NASA Technical Reports Server (NTRS)

    Kashlinsky, A.; Leisawitz, D.

    2004-01-01

    With upcoming missions in mid- and far-Infrared there is a need for software packages to reliably simulate the planned observations. This would help in both planning the observation and scanning strategy and in developing the concepts of the far-off missions. As this workshop demonstrated, many of the new missions are to be in the far-IR range of the electromagnetic spectrum and at the same time will map the sky with a sub-arcsec angular resolution. We present here a computer package for simulating foreground maps for the planned sub-mm and far-IR missions. such as SPECS. The package allows to study confusion limits and simulate cosmological observations for specified sky location interactively and in real time. Most of the emission at wavelengths long-ward of approximately 50 microns is dominated by Galactic cirrus and Zodiacal dust emission. Stellar emission at these wavelengths is weak and is for now neglected. Cosmological sources (distant and not-so-distant) galaxies for specified cosmologies will be added. Briefly, the steps that the algorithm goes through is described.

  5. A 24mm diameter fibre positioner for spectroscopic surveys

    NASA Astrophysics Data System (ADS)

    Hörler, Philipp; Kronig, Luzius; Kneib, Jean-Paul; Bleuler, Hannes; Bouri, Mohamed

    2016-07-01

    One of the big research topics in modern cosmology is the mystery of dark Energy. To unveil the secret, cosmologists want to measure precisely the evolution of large scale structures in the universe. One way of doing so is to measure the 3D location of a high number of galaxies. By measuring the redshift of a galaxy, it is possible to find its distance. In order to measure a high number of galaxies in a practical amount of time, we need to observe multiple objects in parallel. Instead of a spectrograph, thousands of optical fibres are placed in the focal plane of a telescope. They will transmit the light of many objects to a spectrograph. Each fibre has to be positioned to several μm precision in the focal plane of a telescope for each exposure. Each fibre is positioned by a 2-axis fibre positioner. In this paper such a fibre positioner with 24-mm diameter is presented. It is driven by two brushless DC motors in combination with a backlash free gearbox. The positioner has an optimal central fibre path and improved angular alignment. The fibre runs through the centre of the positioner and is only bent at the top to reach its target position. In this way, the flexion and torsion of the fibre are minimal. In addition to the high positioning accuracy, the design is optimized to allow a minimal tilt error of the fibre. This is demonstrated using a novel optical tilt measurement system.

  6. Manufacturing and performance test of an 800-mm space optic

    NASA Astrophysics Data System (ADS)

    Krödel, Matthias R.; Ozaki, Tsuyoshi; Kume, Masami; Furuya, Akira; Yui, Yukari Y.; Imai, Hiroko; Katayama, Haruyoshi; Tange, Yoshio; Nakagawa, Takao; Kaneda, Hidehiro

    2008-07-01

    Next generation space telescopes, which are currently being developed in the US and Europe, require large-scale light-weight reflectors with high specific strength, high specific stiffness, low CTE, and high thermal conductivity. To meet budget constraints, they also require materials that produce surfaces suitable for polishing without expensive over-coatings. HB-Cesic - a European and Japanese trademark of ECM - is a Hybrid Carbon-Fiber Reinforced SiC composite developed jointly by ECM and MELCO to meet these challenges. The material's mechanical performance, such as stiffness, bending strength, and fracture toughness are significantly improved compared to the classic ECM Cesic material (type MF). Thermal expansion and thermal conductivity of HB-Cesic at cryogenic temperatures are now partly established; and excellent performance for large future space mirrors and structures are expected. This paper presents the design and manufacturing of an 800-mm mirror for space application, starting with the C/C raw material preparation to the finishing of the components, including the polishing of the mirror. The letters "HB" in HB-Cesic stand for "hybrid" to indicate that the C/C raw material is composed of a mixture of different types of chopped, short carbon-fibers.

  7. Mapping wetlands on beaver flowages with 35-mm photography

    USGS Publications Warehouse

    Kirby, R.E.

    1976-01-01

    Beaver flowages and associated wetlands on the Chippewa National Forest, north-central Minnesota, were photographed from the ground and from the open side window of a small high-wing monoplane. The 35-mm High Speed Ektachrome transparencies obtained were used to map the cover-type associations visible on the aerial photographs. Nearly vertical aerial photos were rectified by projecting the slides onto a base map consisting ofcontrol points located by plane-table survey. Maps were prepared by tracing the recognizable stands of vegetation in the rectified projection at the desired map scale. Final map scales ranging from 1:260 to 1:571 permitted identification and mapping of 26 cover-type associations on 10 study flowages in 1971. This cover-mapping technique was economical and substituted for detailed ground surveys. Comparative data from 10 flowages were collected serially throughout the entire open-water season. Although developed for analysis of waterfowl habitat, the technique has application to other areas of wildlife management and ecological investigation.

  8. Distinct localizations and repression activities of MM-1 isoforms toward c-Myc.

    PubMed

    Hagio, Yuko; Kimura, Yumiko; Taira, Takahiro; Fujioka, Yuko; Iguchi-Ariga, Sanae M M; Ariga, Hiroyoshi

    2006-01-01

    MM-1 was identified as a c-Myc-binding protein and has been reported to repress the E-box-dependent transcription activity of c-Myc by recruiting HDAC1 complex via TIF1 beta/KAP1. In this study, originally isolated MM-1 was found to be a fusion protein comprised of the N-terminal 13 amino acids from the sequence of chromosome 14 and of the rest of the amino acids from that of chromosome 12 and was found to be expressed ubiquitously in all human tissues. Four splicing isoforms of MM-1, MM-1alpha, MM-1beta, MM-1gamma, and MM-1delta, which are derived from the sequence of chromosome 12, were then identified. Of these isoforms, MM-1alpha, MM-1gamma, and MM-1delta were found to be expressed in tissue-specific manners and MM-1beta was found to be expressed ubiquitously. Although all of the isoforms potentially possessed c-Myc- and TIF1beta-binding activities, MM-1beta and MM-1delta were found to be mainly localized in the cytoplasm and MM-1alpha and MM-1gamma were found to be localized in the nucleus together with both c-Myc and TIF1beta. Furthermore, when repression activities of MM-1 isoforms toward c-Myc transcription activity were examined by reporter gene assays in HeLa cells, MM-1alpha, MM-1gamma, and MM-1gamma, but not MM-1beta, were found to repress transcription activity of c-Myc, and the degrees of repression by MM-1gamma and MM-1delta were smaller than those by MM-1 and MM-1alpha. These results suggest that each MM-1 isoform distinctly regulates c-Myc transcription activity in respective tissues.

  9. Establishment of Cell Lines from Both Myeloma Bone Marrow and Plasmacytoma: SNU_MM1393_BM and SNU_MM1393_SC from a Single Patient

    PubMed Central

    Jung, Woo-June; Ahn, Kwang-Sung; Yoon, Sung-Soo

    2014-01-01

    Purpose. We tried to establish clinically relevant human myeloma cell lines that can contribute to the understanding of multiple myeloma (MM). Materials and Methods. Mononuclear cells obtained from MM patient's bone marrow were injected via tail vein in an NRG/SCID mouse. Fourteen weeks after the injection, tumor developed at subcutis of the mouse. The engraftment of MM cells into mouse bone marrow (BM) was also observed. We separated and cultured cells from subcutis and BM. Results. After the separation and culture of cells from subcutis and BM, we established two cell lines originating from a single patient (SNU_MM1393_BM and SNU_MM1393_SC). Karyotype of the two newly established MM cell lines showed tetraploidy which is different from the karyotype of the patient (diploidy) indicating clonal evolution. In contrast to SNU_MM1393_BM, cell proliferation of SNU_MM1393_SC was IL-6 independent. SNU_MM1393_BM and SNU_MM1393_SC showed high degree of resistance against bortezomib compared to U266 cell line. SNU_MM1393_BM had the greater lethality compared to SNU_MM1393_SC. Conclusion. Two cell lines harboring different site tropisms established from a single patient showed differences in cytokine response and lethality. Our newly established cell lines could be used as a tool to understand the biology of multiple myeloma. PMID:25343143

  10. 0.8mm extragalactic surveys of nearby galaxies

    NASA Astrophysics Data System (ADS)

    Villicaña-Pedraza, Ilhuiyolitzin; Martín, Sergio; Martín-Pintado, Jesus; Requena-Torres, Miguel; Guesten, Rolf; Armijos, Jairo; Pérez-Beaupuits, Juan Pablo; Klein, Bernd; Heyminck, Stefan; Díaz, Angeles I.; Binette, Luc; Carreto-Parra, Francisco; Aladro, Rebeca

    2017-03-01

    We present the first submillimetric line survey of extragalactic sources carried out by APEX. The surveys cover the 0.8 mm atmospheric window from 270 to 370GHz toward NGC253, NGC4945 and Arp220. We found in NGC 253, 150 transitions of 26 molecules. For NGC 4945, 136 transitions of 24 molecules, and 64 transitions of 17 molecules for Arp 220. Column densities and rotation temperatures have been determinate using the Local Thermodinamical Equilibrium(LTE) line profile simulation and fitting in the MADCUBA IJ software. The differences found in ratios between the Galactic Center and the starburst galaxies NGC 4945 and NGC 253 suggest that the gas is less processed in the latter than in the Galactic Center. The high 18O/17O ratios in the galaxies NGC 4945 and NGC 253 suggest also material less processed in the nuclei of these galaxies than in the Galactic Center. This is consistent with the claim that 17O is a more representative primary product than 18O in stellar nucleosynthesis (Wilson and Rood 1994); Also, we did a Multitransitions study of H3O+ at 307GHz, 364GHz, 388GHz and 396GHz. From our non-LTE analysis of H3O+ in NGC253 with RADEX we found that the collisional excitation can not explain the observed intensity of the ortho 396 GHz line. Excitation by radiation from the dust in the Far-IR can roughly explain the observations if the H2 densities are relatively low. From the derived H3O+ column densities we conclude that the chemistry of this molecule is dominated by ionization produce by the starburst in NGC253 (UV radiation from the O stars) and Arp 220 (cosmic rays from the supernovae) and likely from the AGN in NGC4549 (X-rays ); Finally, we report, for the first time, the tentative detection of the molecular ion HCNH+ (precursor of HCN and HNC) toward a galaxy, NGC4945, abundance explain the claimed enhancement of HCN abundance in the AGN, due to the enhancement of the ionization rate by X-rays. The abundance is much larger than the Galactic center of the

  11. Dosimetric study of the 15 mm ROPES eye plaque

    SciTech Connect

    Granero, D.; Perez-Calatayud, J.; Ballester, F.; Casal, E.; Frutos, J.M. de

    2004-12-01

    The main aim of this paper is to make a study of dose-rate distributions obtained around the 15 mm, radiation oncology physics and engineering services, Australia (ROPES) eye plaque loaded with {sup 125}I model 6711 radioactive seeds. In this study, we have carried out a comparison of the dose-rate distributions obtained by the algorithm used by the Plaque Simulator (PS) (BEBIG GmbH, Berlin, Germany) treatment planning system with those obtained by means of the Monte Carlo method for the ROPES eye plaque. A simple method to obtain the dose-rate distributions in a treatment planning system via the superposition of the dose-rate distributions of a seed placed in the eye plaque has been developed. The method uses eye plaque located in a simplified geometry of the head anatomy and distributions obtained by means of the Monte Carlo code GEANT4. The favorable results obtained in the development of this method suggest that it could be implemented on a treatment planning system to improve dose-rate calculations. We have also found that the dose-rate falls sharply along the eye and that outside the eye the dose-rate is very low. Furthermore, the lack of backscatter photons from the air located outside the eye-head phantom produces a dose reduction negligible for distances from the eye-plaque r<1 cm but reaches up to 20% near the air-eye interface. Results showed that the treatment planning system lacks accuracy around the border of the eye (in the sclera and the surrounding area) due to the simplicity of the algorithm used. The BEBIG treatment planning system uses a global attenuation factor that takes into account the effect of the eye plaque seed carrier and the lack of backscatter photons caused by the metallic cover, which in the case of a ROPES eye plaque has a default value of T=1 (no correction). In the present study, a global attenuation factor T=0.96 and an air-interface correction factor which improve on treatment planning system calculations were obtained.

  12. MALT-45: A 7 mm survey of the southern Galaxy

    NASA Astrophysics Data System (ADS)

    Jordan, Christopher Harry

    2015-09-01

    -0 for CS lies within the 7mm waveband, which also contains the poorly understood class I CH3OH maser. Unlike the class II variant, class I masers are not exclusively associated with HMSF, but do appear in star-forming regions across a wide range of evolutionary stages. A large problem for class I CH3OH maser studies is the bias in the targeted searches which have been used to find them; they have only been identified towards other masing regions (such as class II CH3OH), and therefore the properties of these masers are somewhat unclear. In this thesis, results focus on the MALT-45 survey using the Australia Telescope Compact Array (ATCA) in auto-correlation ('single-dish' mode). To date, MALT-45 has mapped the Galactic plane within 330° *lt; < l < 335°, jbj< 0:5°, which contains several known star-forming regions, including the G333 giant molecular cloud. MALT-45 surveys 12 spectral lines, but primarily CS (1-0), class I CH3OH masers and SiO (1-0) v = 0; 1; 2; 3. Bright, extended CS emission is detected across the survey region, and highlight two distinct velocities, due to different spiral arms of the Galaxy. In addition to the previously known 19 class I CH3OH masers, 58 new masers were detected. SiO masers were detected towards 47 regions, in various combinations of vibrational mode v = 1; 2; 3, all towards evolved infrared stars. Thermal SiO v = 0 emission is also detected across the survey region. Major science results from MALT-45 include: (i) A CS to NH3 comparison, which highlights cold, dense clumps as well as hot, evolved clumps. The cold and dense clumps appear to have self-absorption of CS emission in their centres and a relative over-abundance of NH3, while evolved clumps appear to have very little NH3 emission, despite being a dense gas tracer; (ii) Almost all (94 per cent) of ATLASGAL 870 um dust emission point sources are associated with at least a 3σ peak of CS emission; (iii) By comparing with peak CS velocities, class I CH3OH masers are good

  13. Kraft-Wärmekopplung und Blockheiz-Kraftwerke BHKW

    NASA Astrophysics Data System (ADS)

    Zahoransky, Richard; Allelein, Hans-Josef; Bollin, Elmar; Oehler, Helmut; Schelling, Udo

    Die thermischen Wirkungsgrade von Kraftwerken zur Stromerzeugung sind relativ gering. Beispielsweise erreichen moderne Kohlekraftwerke heute bis etwa 45 %, Gasturbinen maximal 40 % und Diesel-Motoren nicht über 50 %. Kombinations-Kraftwerke, Gas- und Dampfturbinen-Prozesse können an die 60 % thermischer Wirkungsgrad bei der Umwandlung der zugeführten Wärme in mechanische bzw. elektrische Energie erzielen. Ein ähnlich hoher Wert wird in Zukunft von den Brennstoffzellen erwartet. Der nicht in Arbeit umgewandelte Anteil der zugeführten Wärme fällt als Abwärme an und geht ungenutzt in die Umgebung. Ein Teil dieser Abwärme lässt sich durch entsprechende Installationen bei allen Kraftwerksprozessen zur Wassererwärmung oder zur Dampferzeugung für industrielle Zwecke nutzen. Für Heizzwecke genügt eine Temperatur der Abwärme von 60 %C bis 80 %C, während die Erzeugung von Industriedampf deutlich höhere Temperaturen voraussetzt.

  14. BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice

    PubMed Central

    Puissant, Alexandre; Richez, Valentine; Cassel, Romeo; Fenouille, Nina; Gilleron, Jerome; Bailly-Maitre, Beatrice; Mallavialle, Aude; Marchetti, Sandrine; Amiot, Martine; Gomez-Bougie, Patricia; Avet-Loiseau, Herve; Hofman, Paul; Karsenti, Jean-Michel; Jeandel, Pierre-Yves; Blin-Wakkach, Claudine; Fuzibet, Jean-Gabriel

    2016-01-01

    Multiple myeloma (MM) evolves from a premalignant condition known as monoclonal gammopathy of undetermined significance (MGUS). However, the factors underlying the malignant transformation of plasmocytes in MM are not fully characterized. We report here that Eµ-directed expression of the antiapoptotic Bcl-B protein in mice drives an MM phenotype that reproduces accurately the human disease. Indeed, with age, Eµ-bcl-b transgenic mice develop the characteristic features of human MM, including bone malignant plasma cell infiltration, a monoclonal immunoglobulin peak, immunoglobulin deposit in renal tubules, and highly characteristic bone lytic lesions. In addition, the tumors are serially transplantable in irradiated wild-type mice, underlying the tumoral origin of the disease. Eµ-bcl-b plasmocytes show increased expression of a panel of genes known to be dysregulated in human MM pathogenesis. Treatment of Eµ-bcl-b mice with drugs currently used to treat patients such as melphalan and VELCADE efficiently kills malignant plasmocytes in vivo. Finally, we find that Bcl-B is overexpressed in plasmocytes from MM patients but neither in MGUS patients nor in healthy individuals, suggesting that Bcl-B may drive MM. These findings suggest that Bcl-B could be an important factor in MM disease and pinpoint Eµ-bcl-b mice as a pertinent model to validate new therapies in MM. PMID:27455953

  15. BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice.

    PubMed

    Hamouda, Mohamed-Amine; Jacquel, Arnaud; Robert, Guillaume; Puissant, Alexandre; Richez, Valentine; Cassel, Romeo; Fenouille, Nina; Roulland, Sandrine; Gilleron, Jerome; Griessinger, Emmanuel; Dubois, Alix; Bailly-Maitre, Beatrice; Goncalves, Diogo; Mallavialle, Aude; Colosetti, Pascal; Marchetti, Sandrine; Amiot, Martine; Gomez-Bougie, Patricia; Rochet, Nathalie; Deckert, Marcel; Avet-Loiseau, Herve; Hofman, Paul; Karsenti, Jean-Michel; Jeandel, Pierre-Yves; Blin-Wakkach, Claudine; Nadel, Bertrand; Cluzeau, Thomas; Anderson, Kenneth C; Fuzibet, Jean-Gabriel; Auberger, Patrick; Luciano, Frederic

    2016-08-22

    Multiple myeloma (MM) evolves from a premalignant condition known as monoclonal gammopathy of undetermined significance (MGUS). However, the factors underlying the malignant transformation of plasmocytes in MM are not fully characterized. We report here that Eµ-directed expression of the antiapoptotic Bcl-B protein in mice drives an MM phenotype that reproduces accurately the human disease. Indeed, with age, Eµ-bcl-b transgenic mice develop the characteristic features of human MM, including bone malignant plasma cell infiltration, a monoclonal immunoglobulin peak, immunoglobulin deposit in renal tubules, and highly characteristic bone lytic lesions. In addition, the tumors are serially transplantable in irradiated wild-type mice, underlying the tumoral origin of the disease. Eµ-bcl-b plasmocytes show increased expression of a panel of genes known to be dysregulated in human MM pathogenesis. Treatment of Eµ-bcl-b mice with drugs currently used to treat patients such as melphalan and VELCADE efficiently kills malignant plasmocytes in vivo. Finally, we find that Bcl-B is overexpressed in plasmocytes from MM patients but neither in MGUS patients nor in healthy individuals, suggesting that Bcl-B may drive MM. These findings suggest that Bcl-B could be an important factor in MM disease and pinpoint Eµ-bcl-b mice as a pertinent model to validate new therapies in MM.

  16. Physik gestern und heute: Fragwürdiges beim Millikan-Versuch

    NASA Astrophysics Data System (ADS)

    Heering, Peter

    2006-09-01

    Robert A. Millikan erhielt 1923 als erster amerikanischer Physiker den Nobelpreis für Physik. Geehrt wurde er für seine Präzisionsmessungen zum Photoeffekt und zur experimentellen Bestimmung der elektrischen Elementarladung. Millikans Experimente zur Elementarladung sind auch heute noch ein Standardthema im schulischen Physikunterricht, gleichzeitig werfen sie aber eine Reihe von wissenschaftstheoretischen und ethisch relevanten Fragen auf.

  17. Modellierung und Simulation des Substrat-Rauschens in integrierten RF CMOS-Schaltungen

    NASA Astrophysics Data System (ADS)

    Lin, L.; Xiong, J.; Mathis, W.

    2009-05-01

    Im integrierten CMOS-Schaltungsentwurf kann das Substrat-Rauschen, das vom digitalen Teil entsteht, die Funktionalität des analogen Teils stark beeinflussen. Es wird daher immer wichtiger, das Substrat als ein Medium der Rauschen-Propagation genau zu modellieren. Im vorliegenden Artikel wird ein auf der Finite Elemente Methode (FEM) und Modellordnungsreduktion (MOR) basiertes Modellierungsverfahren zur Admittanzen-Extraktion im Halbleitersubstrat vorgestellt. Nach der Diskretisierung mit FEM wird das Substrat im Allgemeinen als ein resistives/kapazitives Netz angesehen. Durch Bestimmung der Admittanz-Matrix und MOR ist es möglich ein äquivalentes Dreipol-Modell zwischen digitalem und analogem Teil über das Substrat zu bilden. Das Ergebnis der Modellierung wird dargestellt und mit numerischer Simulation des Substrat-Rauschens verglichen. Die Modellierung ermöglicht es, die Einflüsse des Substrat-Rauschens im Schaltungsentwurf zu berücksichtigen und so bestehende CMOS-Schaltungsarchitekturen zu optimieren.

  18. Variationeller Ansatz für eine integrierte Segmentierung und nicht-lineare Registrierung

    NASA Astrophysics Data System (ADS)

    Schmidt-Richberg, Alexander; Ehrhardt, Jan; Handels, Heinz

    Vierdimensionale tomographische Bilddaten ermöglichen neuartige Therapie- und Diagnoseverfahren in der medizinischen Praxis. Voraussetzung dafür sind oft die räumlich-zeitliche Segmentierung anatomischer Strukturen in den 4D- Daten und die Bestimmung ihrer dynamischen Eigenschaften durch Schätzung der 3D-Bewegungsfelder mittels nicht-linearer Registrierungsverfahren. In dieser Arbeit wird ein Ansatz vorgestellt, mit dem sich Level-Set-Segmentierung und diffusive, nicht-lineare Registrierung unter Berücksichtigung ihrer wechelseitigen Abhängigkeiten integriert lösen lassen. Die Aufgabe wird als Energieminimierung formuliert und ein variationelles Lösungsverfahren angegeben. Anschließend wird der Ansatz an Phantom- und CT-Patientendaten am Beispiel der Leber validiert.

  19. Rabring7 Degrades c-Myc through Complex Formation with MM-1

    PubMed Central

    Torii, Ayako; Tashiro, Erika; Miyazawa, Makoto; Ariga, Hiroyoshi; Iguchi-Ariga, Sanae M. M.

    2012-01-01

    We have reported that a novel c-Myc-binding protein, MM-1, repressed E-box-dependent transcription and transforming activities of c-Myc and that a mutation of A157R in MM-1, which is often observed in patients with leukemia or lymphoma, abrogated all of the repressive activities of MM-1 toward c-Myc, indicating that MM-1 is a novel tumor suppressor. MM-1 also binds to the ubiquitin-proteasome system, leading to degradation of c-Myc. In this study, we identified Rabring7, a Rab7-binding and RING finger-containing protein, as an MM-1-binding protein, and we found that Rabring7 mono-ubiquitinated MM-1 in the cytoplasm without degradation of MM-1. Rabring7 was also found to bind to c-Myc and to ubiquitinate c-Myc in a threonine 58-dependent manner. When c-Myc was co-transfected with MM-1 and Rabring7, c-Myc was degraded. Furthermore, it was found that c-Myc was stabilized in MM-1-knockdown cells even when Rabring7 was transfected and that Rabring7 was bound to and co-localized with MM-1 and c-Myc after MM-1 and Rabring7 had been translocated from the cytoplasm to the nucleus. These results suggest that Rabring7 stimulates c-Myc degradation via mono-ubiquitination of MM-1. PMID:22844532

  20. Rabring7 degrades c-Myc through complex formation with MM-1.

    PubMed

    Narita, Rina; Kitaura, Hirotake; Torii, Ayako; Tashiro, Erika; Miyazawa, Makoto; Ariga, Hiroyoshi; Iguchi-Ariga, Sanae M M

    2012-01-01

    We have reported that a novel c-Myc-binding protein, MM-1, repressed E-box-dependent transcription and transforming activities of c-Myc and that a mutation of A157R in MM-1, which is often observed in patients with leukemia or lymphoma, abrogated all of the repressive activities of MM-1 toward c-Myc, indicating that MM-1 is a novel tumor suppressor. MM-1 also binds to the ubiquitin-proteasome system, leading to degradation of c-Myc. In this study, we identified Rabring7, a Rab7-binding and RING finger-containing protein, as an MM-1-binding protein, and we found that Rabring7 mono-ubiquitinated MM-1 in the cytoplasm without degradation of MM-1. Rabring7 was also found to bind to c-Myc and to ubiquitinate c-Myc in a threonine 58-dependent manner. When c-Myc was co-transfected with MM-1 and Rabring7, c-Myc was degraded. Furthermore, it was found that c-Myc was stabilized in MM-1-knockdown cells even when Rabring7 was transfected and that Rabring7 was bound to and co-localized with MM-1 and c-Myc after MM-1 and Rabring7 had been translocated from the cytoplasm to the nucleus. These results suggest that Rabring7 stimulates c-Myc degradation via mono-ubiquitination of MM-1.

  1. Experimental characterization and system simulations of depth of interaction PET detectors using 0.5 mm and 0.7 mm LSO arrays.

    PubMed

    James, Sara St; Yang, Yongfeng; Wu, Yibao; Farrell, Richard; Dokhale, Purushottam; Shah, Kanai S; Cherry, Simon R

    2009-07-21

    Small animal PET scanners may be improved by increasing the sensitivity, improving the spatial resolution and improving the uniformity of the spatial resolution across the field of view. This may be achieved by using PET detectors based on crystal elements that are thin in the axial and transaxial directions and long in the radial direction, and by employing depth of interaction (DOI) encoding to minimize the parallax error. With DOI detectors, the diameter of the ring of the PET scanner may also be decreased. This minimizes the number of detectors required to achieve the same solid angle coverage as a scanner with a larger ring diameter and minimizes errors due to non-collinearity of the annihilation photons. In this study, we characterize prototype PET detectors that are finely pixelated with individual LSO crystal element sizes of 0.5 mm x 0.5 mm x 20 mm and 0.7 mm x 0.7 mm x 20 mm, read out at both ends by position sensitive avalanche photodiodes (PSAPDs). Both a specular reflector and a diffuse reflector were evaluated. The detectors were characterized based on the ability to clearly resolve the individual crystal elements, the DOI resolution and the energy resolution. Our results indicate that a scanner based on any of the four detector designs would offer improved spatial resolution and more uniform spatial resolution compared to present day small animal PET scanners. The greatest improvements to spatial resolution will be achieved when the detectors employing the 0.5 mm x 0.5 mm x 20 mm crystals are used. Monte Carlo simulations were performed to demonstrate that 2 mm DOI resolution is adequate to ensure uniform spatial resolution for a small animal PET scanner geometry using these detectors. The sensitivity of such a scanner was also simulated using Monte Carlo simulations and was shown to be greater than 10% for a four ring scanner with an inner diameter of 6 cm, employing 20 detectors per scanner ring.

  2. Experimental characterization and system simulations of depth of interaction PET detectors using 0.5 mm and 0.7 mm LSO arrays

    NASA Astrophysics Data System (ADS)

    James, Sara St; Yang, Yongfeng; Wu, Yibao; Farrell, Richard; Dokhale, Purushottam; Shah, Kanai S.; Cherry, Simon R.

    2009-07-01

    Small animal PET scanners may be improved by increasing the sensitivity, improving the spatial resolution and improving the uniformity of the spatial resolution across the field of view. This may be achieved by using PET detectors based on crystal elements that are thin in the axial and transaxial directions and long in the radial direction, and by employing depth of interaction (DOI) encoding to minimize the parallax error. With DOI detectors, the diameter of the ring of the PET scanner may also be decreased. This minimizes the number of detectors required to achieve the same solid angle coverage as a scanner with a larger ring diameter and minimizes errors due to non-collinearity of the annihilation photons. In this study, we characterize prototype PET detectors that are finely pixelated with individual LSO crystal element sizes of 0.5 mm × 0.5 mm × 20 mm and 0.7 mm × 0.7 mm × 20 mm, read out at both ends by position sensitive avalanche photodiodes (PSAPDs). Both a specular reflector and a diffuse reflector were evaluated. The detectors were characterized based on the ability to clearly resolve the individual crystal elements, the DOI resolution and the energy resolution. Our results indicate that a scanner based on any of the four detector designs would offer improved spatial resolution and more uniform spatial resolution compared to present day small animal PET scanners. The greatest improvements to spatial resolution will be achieved when the detectors employing the 0.5 mm × 0.5 mm × 20 mm crystals are used. Monte Carlo simulations were performed to demonstrate that 2 mm DOI resolution is adequate to ensure uniform spatial resolution for a small animal PET scanner geometry using these detectors. The sensitivity of such a scanner was also simulated using Monte Carlo simulations and was shown to be greater than 10% for a four ring scanner with an inner diameter of 6 cm, employing 20 detectors per scanner ring.

  3. Sub-mm Jet Properties of the X-Ray Binary Swift J1745-26

    NASA Astrophysics Data System (ADS)

    Tetarenko, A. J.; Sivakoff, G. R.; Miller-Jones, J. C. A.; Curran, P. A.; Russell, T. D.; Coulson, I. M.; Heinz, S.; Maitra, D.; Markoff, S. B.; Migliari, S.; Petitpas, G. R.; Rupen, M. P.; Rushton, A. P.; Russell, D. M.; Sarazin, C. L.

    2015-05-01

    We present the results of our observations of the early stages of the 2012-2013 outburst of the transient black hole X-ray binary (BHXRB), Swift J1745-26, with the Very Large Array, Submillimeter Array, and James Clerk Maxwell telescope (SCUBA-2). Our data mark the first multiple-band mm and sub-mm observations of a BHXRB. During our observations the system was in the hard accretion state producing a steady, compact jet. The unique combination of radio and mm/sub-mm data allows us to directly measure the spectral indices in and between the radio and mm/sub-mm regimes, including the first mm/sub-mm spectral index measured for a BHXRB. Spectral fitting revealed that both the mm (230 GHz) and sub-mm (350 GHz) measurements are consistent with extrapolations of an inverted power law from contemporaneous radio data (1-30 GHz). This indicates that, as standard jet models predict, a power law extending up to mm/sub-mm frequencies can adequately describe the spectrum, and suggests that the mechanism driving spectral inversion could be responsible for the high mm/sub-mm fluxes (compared to radio fluxes) observed in outbursting BHXRBs. While this power law is also consistent with contemporaneous optical data, the optical data could arise from either jet emission with a jet spectral break frequency of {{ν }break}≳ 1× {{10}14} Hz or the combination of jet emission with a lower jet spectral break frequency of {{ν }break}≳ 2× {{10}11} Hz and accretion disk emission. Our analysis solidifies the importance of the mm/sub-mm regime in bridging the crucial gap between radio and IR frequencies in the jet spectrum, and justifies the need to explore this regime further.

  4. Retrospective Comparison of Intermediate-term Efficacy of 350 mm2 Glaucoma Drainage Implants and Medium-sized 230-250 mm2 Implants

    PubMed Central

    Meyer, Alissa M; Rodgers, Cooper D; Zou, Baiming; Rosenberg, Nicole C; Webel, Aaron D

    2017-01-01

    ABSTRACT Aim To compare the intermediate-term efficacy of a large surface area Baerveldt 350 mm2 glaucoma drainage device (GDD) with medium surface area implants (Baerveldt 250 mm2 and Molteno 3, 230, or 245 mm2). Design This is a retrospective, nonrandomized comparative trial. Materials and methods A total of 94 eyes of 94 patients of mixed glaucoma diagnoses without any prior glaucoma surgical procedures and who had undergone a glaucoma drainage implant surgery with either a large Baerveldt 350 mm2 GDD or a medium-sized GDD (Baerveldt 250 mm2 or Molteno 230 or 245 mm2) were reviewed for intraocular pressure (IOP), number of glaucoma medications, and visual acuity (VA) preoperatively, and at 1, 2, and 3 years postprocedure. Results No significant differences were found in mean IOP, number of glaucoma medications used, and VA at 1, 2, and 3 years postoperatively. The rate of additional glaucoma procedures was similar between the two groups. Conclusion There is no clear evidence that a larger implant surface area beyond 230 to 250 mm2 is advantageous in providing intermediate-term IOP control. Clinical significance It may be technically easier to surgically place a GDD that does not need to have its wings placed underneath the recti muscles, and the IOP results are similar. How to cite this article Meyer AM, Rodgers CD, Zou B, Rosenberg NC, Webel AD, Sherwood MB. Retrospective Comparison of Intermediate-term Efficacy of 350 mm2 Glaucoma Drainage Implants and Medium-sized 230-250 mm2 Implants. J Curr Glaucoma Pract 2017;11(1):8-15. PMID:28138212

  5. Kernschmelze Der nachhaltige Einfluss von Nuklearwaffen auf Politik und Wirtschaft

    NASA Astrophysics Data System (ADS)

    Greiner, Bernd

    "Was sollen wir von einer Kultur halten, der die Ethik stets als wesentliches Element des menschlichen Lebens galt, die aber - außer in fachlicher oder spieltheoretischer Terminologie - nicht in der Lage war, über die Möglichkeit zu sprechen, nahezu alle Menschen zu töten?" Der Fragesteller gehört zu den berühmtesten Physikern des 20. Jahrhunderts und zu den nach wie vor Umstrittensten. über ihn wurde in den 1960er Jahren ein international viel beachtetes Theaterstück geschrieben, vor wenigen Jahren gar eine Oper.

  6. Was leistet ein Sportler? Kraft, Leistung und Energie im Muskel

    NASA Astrophysics Data System (ADS)

    Thaller, Sigrid; Mathelitsch, Leopold

    2006-01-01

    Der Leistungsbegriff ist im Sport weiter gefasst als in der Physik. In beiden Fällen liegt der Fokus jedoch auf einer pro Zeiteinheit erfolgten Energieumsetzung. Allerdings gibt die rein physikalische Leistung nicht immer Auskunft über den Energieumsatz der Muskeln. Die Muskelkraft hängt von der Kontraktionsgeschwindigkeit des Muskels ab. Ein Muskel verhält sich also anders als eine Feder. Für den Hochleistungssport müssen die Energieumsätze der Muskeln durch spezielle Trainings- und Nahrungsprogramme optimiert werden.

  7. RF Measurements on DXRL (Deep X-ray Li-thog-ra-phy)-Fabricated mmWave Accelerating Cavity Structures at the Advanced Photon Source (APS)

    NASA Astrophysics Data System (ADS)

    Song, J. J.; Kang, Y. W.

    1997-05-01

    Recently rf structures have been proposed for frequencies in the mmwave (30--300 GHz) range. This miniaturization is feasible with a 3-D micromachining process known as LIGA (German acronym for lithographe, galvanoformung, und abformung) or DXRL (deep x-ray lithography).(J.J. Song, et. al, ``LIGA-Fabrication of mmWave Accelerating Cavity Structures at the Advanced Photon Source (APS),'' these proceedings.) A 32-cell 108-GHz constant-impedance cavity and a 66-cell 94-GHz constant-gradient cavity were fabricated using DXRL micromachining with the synchrotron radiation sources at NSLS and APS. Their eventual application could be parts of linear accelerators, microwave undulators, or free-electron lasers. Radiofrequency measurement on the structures was performed by the bead-perturbation method with e-beam sputtered aluminum beads. The form factor of the bead was measured with the pillbox cavity and compared with the calculation. This paper will describe the rf measur! ement on the mmwave cavity structure.

  8. Evaluation of the hemodynamics in straight 6-mm and tapered 6- to 8-mm grafts as upper arm hemodialysis vascular access.

    PubMed

    Sarmast, M; Niroomand-Oscuii, H; Ghalichi, F; Samiei, E

    2014-09-01

    The present study is intended to investigate and compare the hemodynamics in two different sizes of hemodialysis arteriovenous grafts for upper arm hemodialysis vascular access: 8-mm tapered to 6-mm at the arterial side and straight 6 mm. A computational simulation approach is presented for this study, which is validated against the available experimental and numerical pressure measurements in the literature. The imposed boundary conditions at the arterial inlet and venous outlet boundaries of the models are physiological velocity and pressure waveforms, respectively. Blood flow fields and distribution patterns of the hemodynamic indices including wall shear stress (WSS) as one of the major hemodynamic parameters of the cardiovascular system and spatial wall shear stress gradient (SWSSG) as an indicator of disturbed flow patterns and hence susceptible sites of lesion developments are analyzed and compared between the two grafts. The tapered 6- to 8-mm graft seemingly is associated with less disturbed flow patterns within the venous anastomosis (VA) and the vein downstream while benefiting from higher blood flow rates within. Also, it shows a definitive advantage in terms of WSS and SWSSG distribution patterns around the VA and throughout the vein downstream with significantly lower values, which reduce the risk of thrombosis formation and stenotic lesion developments. The only disadvantage encountered in using 6- to 8-mm tapered graft is higher values of hemodynamic parameters at the arterial junction attributable to its significantly higher mean blood flow rate within. The results clearly indicate that the tapered 6- to 8-mm graft entirely outperforms straight 6-mm graft hemodynamically as an upper arm hemodialysis vascular access graft and confirms clinical data in the literature, which suggests advantageous use of tapered 6- to 8-mm grafts in the creation of upper arm brachioaxillary hemodialysis vascular access grafts in selected groups of patients with

  9. Recovery of macroinvertebrates by screening in the field: a comparison between coarse (1.18 mm) and fine (0.60 mm) mesh sieves

    USGS Publications Warehouse

    Dukerschein, J.T.; Gent, R.; Sauer, J.

    1996-01-01

    We evaluated the potential loss of target benthic macroinvertebrates from coarse-mesh field wash down of samples through a 1.18-mm mesh sieve nested on a 0.60-mm mesh sieve. Visible target organisms (midges, mayflies, and fingernail clams) in the 1.18-mm mesh sieve were removed from the sample and enumerated in the field. The entire contents of both sieves were preserved for subsequent laboratory enumeration under 4X magnification. Percent recoveries from each treatment were based on total intact organisms found in all sieves. Percent recovery for fingernail clams found in the field (31%) was lower than for mayflies (79%) and midges (88%). Laboratory enumeration of organisms retained by the 1.18-mm sieve yielded additional fingernail clams (to total 74% recovered in the field and lab), mayflies (to total 89%), and midges (to total 91%). If the 1.18-mm sieve is used alone in the field, it is adequate to monitor mayflies, midges >1 cm, and adult fingernail clams greater than or equal to 5.0 mm shell length.

  10. Comparison of Radii Sets, Entropy, QM Methods, and Sampling on MM-PBSA, MM-GBSA, and QM/MM-GBSA Ligand Binding Energies of F. tularensis Enoyl-ACP Reductase (FabI)

    PubMed Central

    Su, Pin-Chih; Tsai, Cheng-Chieh; Mehboob, Shahila; Hevener, Kirk E.; Johnson, Michael E.

    2015-01-01

    To validate a method for predicting the binding affinities of FabI inhibitors, three implicit solvent methods, MM-PBSA, MM-GBSA and QM/MM GBSA were carefully compared using sixteen benzimidazole inhibitors in complex with F. tularensis FabI. The data suggests that the prediction results are sensitive to radii sets, GB methods, QM Hamiltonians, sampling protocols, and simulation length, if only one simulation trajectory is used for each ligand. In this case, QM/MM-GBSA using 6 ns MD simulation trajectories together with GBneck2, PM3, and the mbondi2 radii set, generate the closest agreement with experimental values (r2= 0.88). However, if the three implicit solvent methods are averaged from six 1 ns MD simulations for each ligand (called “multiple independent sampling”), the prediction results are relatively insensitive to all the tested parameters. Moreover, MM/GBSA together with GBHCT and mbondi, using 600 frames extracted evenly from six 0.25 ns MD simulations, can also provide accurate prediction to experimental values (r2 = 0.84). Therefore, the multiple independent sampling method can be more efficient than a single, long simulation method. Since future scaffold expansions may significantly change the benzimidazole's physiochemical properties (charges, etc.) and possibly binding modes, which may affect the sensitivities of various parameters, the relatively insensitive “multiple independent sampling method” may avoid the need of an entirely new validation study. Moreover, due to large fluctuating entropy values, (QM/)MM-P(G)BSA were limited to inhibitors’ relative affinity prediction, but not the absolute affinity. The developed protocol will support an ongoing benzimidazole lead optimization program. PMID:26216222

  11. Integrierte Segmentierung und Trajektorienberechnung mittels diffeomorpher Registrierung in räumlich-zeitlichen CT-Bildfolgen

    NASA Astrophysics Data System (ADS)

    Schmidt-Richberg, Alexander; Ehrhardt, Jan; Werner, René; Handels, Heinz

    Verfahren zur integrierten Segmentierung und Registrierung von 4D-Bilddaten ermöglichen die Berücksichtigung der gegenseitigen Abhängigkeiten beider Komponenten. Bestehende Ansätze konzentrieren sich dabei meist auf die Betrachtung zweier 3D-Bilder und lassen sich nicht direkt auf vollständige Bildfolgen übertragen. In dieser Arbeit wird ein Verfahren vorgestellt, in dem ein diffeomorpher Registrierungsansatz verwendet wird, um eine integrierte Berechnung von Segmentierungen und 3D-Voxeltrajektorien in 4D-Daten zu ermöglichen.

  12. Der Kalte Krieg in der Peripherie Griechische Physiker und Atomenergie nach dem Zweiten Weltkrieg

    NASA Astrophysics Data System (ADS)

    Vlahakis, George N.

    Die vorliegende Arbeit analysiert Ansichten griechischer Physiker zur Atomenergie und deren mögliche Anwendung nach dem Zweiten Weltkrieg, insbesondere während des Kalten Kriegs. Einerseits werden Ansichten von Physik- Professoren griechischer Universitäten präsentiert - beispielsweise von Dimitrios Hondros, der Student von Arnold Sommerfeld und Mitarbeiter von Peter Debye in München war, und andererseits wird die Politik der griechischen Regierung für die Etablierung eines Forschungsinstitutes diskutiert, das der Entwicklung der Atomenergie dienen sollte; ebenfalls wird eine öffentliche Meinungsumfrage zu diesen Thema, die in den Tageszeitungen der damaligen Zeit präsentiert wurde, diskutiert.

  13. Influence of Implant Design (Cylindrical and Conical) in the Load Transfer Surrounding Long (13mm) and Short (7mm) Length Implants: A Photoelastic Analysis

    PubMed Central

    Gehrke, Sergio Alexandre; Frugis, Victor Lourenço; Shibli, Jamil Awad; Fernandez, Maria Piedad Ramirez; Sánchez de Val, José Eduardo Maté; Girardo, José Luis Calvo; Taschieri, Silvio; Corbella, Stefano

    2016-01-01

    Purpose: This study compared the influence of implant design (cylindrical and conical) in the load transfer on bone surrounding 13mm and 7mm length implants under simulated occlusal loading, using photoelastic analysis. Method: Dental implants of 4mm diameter were divided into four groups, which varied in length and design: Group 1- standard (13 mm) cylindrical implant; Group 2 - standard conical implant; Group 3 – short (7 mm) cylindrical implant, and Group 4 - short conical implant. After the inclusion of the implant models in a photoelastic resin, they were subjected to a static load of 100 N. The lengths of the fringes that were generated were measured in three portions since the implants body: crestal, central and apical portion, parallel to the implant long axis. Furthermore, the entire extension area of dissipation of force was measured. Data were analyzed by one-way ANOVA (α = 0.05). Results: Lower stress was observed at the crestal bone in groups 2 and 4, while the stress levels in groups 1 and 3 were higher with significant differences compared to the other groups (p<0.05). Conclusion: The total amount of stress transmitted to the bone was not affected by implant length under axial loading condition, but changed in relation to the implant design with respect to the concentration of the fringes, which corresponded to the load distribution, with even more dissipation by conical implants. PMID:27843505

  14. Preliminary Analysis of a 27.5 mm Period Undulator for the MBA Lattice

    SciTech Connect

    Abliz, M.; Grimmer, J.

    2016-07-27

    The magnetic design of a 27.5 mm period undulator was performed for the APS MBA Lattice. One purpose of the magnetic design was to decrease the magnetic force in order to operate the undulator successfully at a smaller gap compared to the existing 27 mm undulator at the APS. As a result, the magnetic force is decreased by about 18% at a gap of 11 mm and the total volume of the magnet and the pole is decreased by approximately 22% with the new model. The calculated effective field with the new model was 172 G higher than the existing 27-mm period undulator with a gap of 11 mm. The calculated field roll-off with the new optimized model is within the requirements of the MBA, in the range of ± 5 mm.

  15. Spit-Hole Effects on the Ballistics of a 7.62-mm Cartridge

    DTIC Science & Technology

    2014-02-01

    study to examine the effects of a small caliber (7.62-mm) cartridge’s spit-hole on the interior ballistic performance of the cartridge. The performance...Spit-Hole Effects on the Ballistics of a 7.62-mm Cartridge by John Ritter ARL-TR-6785 February 2014... Ballistics of a 7.62-mm Cartridge John Ritter Weapons and Materials Research Directorate, ARL

  16. Jahre Entwicklung der Instandhaltung - von der ausfallorientierten Instandhaltung zum gemeinsamen TPM und RCM

    NASA Astrophysics Data System (ADS)

    Iske, Friedhelm

    Zur Einleitung meines Beitrages möchte ich von einem Gespräch mit einem Mitarbeiter berichten, das ich als junger Vorgesetzter einer Instandhaltungsgruppe 1988 führte. Der engagierte Mitarbeiter feierte damals sein vierzigjähriges Dienstjubiläum und war stolz auf das von ihm Geleistete sowie auf den besonderen Einsatz seiner Altersgruppe, die nach dem Zweiten Weltkrieg das Werk wieder aufgebaut hatte. Auf meine Frage, was denn damals die erste Aufgabe in der Firma war, bekam ich kurz und knapp und mit einer Selbstverständlichkeit die selbstbewusste Antwort: "Unser Pferd füttern und mit dem Pferd die innerbetrieblichen Transporte erledigen“. Als junger, technisch orientierter Vorgesetzter war ich über diese Antwort sehr überrascht. Gedanklich weit entfernt war die Vorstellung, dass in der Vergangenheit Transporte mit einem Pferd erledigt wurden.

  17. Modellgestützte Fehlererkennung und Diagnose für Common-Rail-Einspritzsysteme

    NASA Astrophysics Data System (ADS)

    Clever, Sebastian

    Moderne Pkw-Dieselmotoren sind mit verschiedensten komplexen mechatronischen Komponenten ausgestattet. So kommen neben Abgasrückführsystemen zur Minderung der Stickoxidemissionen und Turboladern zur Steigerung der Leistungsdichte insbesondere elektronisch gesteuerte Mehrfach-Einspritzsysteme zum Einsatz. Deshalb erhöht sich die Bedeutung einer umfassenden Fehlererkennung und Diagnose, zusätzlich zu den bekannten OBD- und EOBD-Vorgaben, im Rahmen steigender Anforderungen an die Zuverlässigkeit und Verfügbarkeit. Um diese Anforderungen zu erfüllen, bieten sich modellbasierte Verfahren an. Ihr Stand in verschiedenen Gebieten wird zum Beispiel in [1-6] beschrieben. Mit dem Einsatz modellgestützter Fehlererkennungsverfahren bei Verbrennungsmotoren beschäftigen sich beispielsweise [7-18].

  18. Zur ethischen Dimension von Renaturierungsökologie und Ökosystemrenaturierung

    NASA Astrophysics Data System (ADS)

    Ott, Konrad

    Die wissenschaftlich angeleitete Ökosystemrena-turierung kann mittlerweile als eine etablierte Praxis im Bereich des Naturschutzes gelten. Diese Praxis bezieht sich notwendigerweise auf Ziele und Werte und weist damit auch eine naturethische Dimension auf. Daher hat diese Praxis die Aufmerksamkeit auch von Sozialwissenschaftlern und Ethikern auf sich gezogen. Dieses Kapitel geht der Frage nach, wie sich die naturethische Dimension der Ökosystemrenaturierung analysieren und inhaltlich bestimmen lässt. Hierzu erweist sich auch die Auseinandersetzung mit Philosophen als hilfreich, die der Ökosystemrenaturierung ein technizistisches Naturverständnis vorgeworfen haben. Am Ende des Kapitels wird ein in sich gestuftes mögliches naturethisches Selbstverständnis der Ökosystemrenaturierung diskutiert, das den an dieser Praxis Beteiligten Freiheitsgrade der Positionierung belässt.

  19. Application of the Pugh, Eichelberg and Rostoker Theory to the MRL 38 mm Shaped Charge,

    DTIC Science & Technology

    1985-09-01

    66 m M72 LIA2 (LAW) and 84 mm Carl Gustaf anti-tank weapons, and there Is continuing interest in the 103 .’"’’ mm MILAN, a shaped charge warhead which...others are the DESC-1 code of Carleone et al of Dyna East Corp. [7], the JETFORM code at RARDE [8], and the TB/ISL code of Hennequin in France [9...38 mm shaped charge may be too small for exact scaling to-0 apply. The velocity of the tail end of the jet predicted from Fig. 8 is 0.18 mm/us and

  20. A practical large scale/high speed data distribution system using 8 mm libraries

    NASA Technical Reports Server (NTRS)

    Howard, Kevin

    1993-01-01

    Eight mm tape libraries are known primarily for their small size, large storage capacity, and low cost. However, many applications require an additional attribute which, heretofore, has been lacking -- high transfer rate. Transfer rate is particularly important in a large scale data distribution environment -- an environment in which 8 mm tape should play a very important role. Data distribution is a natural application for 8 mm for several reasons: most large laboratories have access to 8 mm tape drives, 8 mm tapes are upwardly compatible, 8 mm media are very inexpensive, 8 mm media are light weight (important for shipping purposes), and 8 mm media densely pack data (5 gigabytes now and 15 gigabytes on the horizon). If the transfer rate issue were resolved, 8 mm could offer a good solution to the data distribution problem. To that end Exabyte has analyzed four ways to increase its transfer rate: native drive transfer rate increases, data compression at the drive level, tape striping, and homogeneous drive utilization. Exabyte is actively pursuing native drive transfer rate increases and drive level data compression. However, for non-transmitted bulk data applications (which include data distribution) the other two methods (tape striping and homogeneous drive utilization) hold promise.

  1. Computed tomography dose assessment for a 160 mm wide, 320 detector row, cone beam CT scanner.

    PubMed

    Geleijns, J; Salvadó Artells, M; de Bruin, P W; Matter, R; Muramatsu, Y; McNitt-Gray, M F

    2009-05-21

    Computed tomography (CT) dosimetry should be adapted to the rapid developments in CT technology. Recently a 160 mm wide, 320 detector row, cone beam CT scanner that challenges the existing Computed Tomography Dose Index (CTDI) dosimetry paradigm was introduced. The purpose of this study was to assess dosimetric characteristics of this cone beam scanner, to study the appropriateness of existing CT dose metrics and to suggest a pragmatic approach for CT dosimetry for cone beam scanners. Dose measurements with a small Farmer-type ionization chamber and with 100 mm and 300 mm long pencil ionization chambers were performed free in air to characterize the cone beam. According to the most common dose metric in CT, namely CTDI, measurements were also performed in 150 mm and 350 mm long CT head and CT body dose phantoms with 100 mm and 300 mm long pencil ionization chambers, respectively. To explore effects that cannot be measured with ionization chambers, Monte Carlo (MC) simulations of the dose distribution in 150 mm, 350 mm and 700 mm long CT head and CT body phantoms were performed. To overcome inconsistencies in the definition of CTDI100 for the 160 mm wide cone beam CT scanner, doses were also expressed as the average absorbed dose within the pencil chamber (D100). Measurements free in air revealed excellent correspondence between CTDI300air and D100air, while CTDI100air substantially underestimates CTDI300air. Results of measurements in CT dose phantoms and corresponding MC simulations at centre and peripheral positions were weighted and revealed good agreement between CTDI300w, D100w and CTDI600w, while CTDI100w substantially underestimates CTDI300w. D100w provides a pragmatic metric for characterizing the dose of the 160 mm wide cone beam CT scanner. This quantity can be measured with the widely available 100 mm pencil ionization chamber within 150 mm long CT dose phantoms. CTDI300w measured in 350 mm long CT dose phantoms serves as an appropriate standard of

  2. Electronic Absorption Spectra from MM and ab initio QM/MM Molecular Dynamics: Environmental Effects on the Absorption Spectrum of Photoactive Yellow Protein

    PubMed Central

    Isborn, Christine M.; Götz, Andreas W.; Clark, Matthew A.; Walker, Ross C.; Martínez, Todd J.

    2012-01-01

    We describe a new interface of the GPU parallelized TeraChem electronic structure package and the Amber molecular dynamics package for quantum mechanical (QM) and mixed QM and molecular mechanical (MM) molecular dynamics simulations. This QM/MM interface is used for computation of the absorption spectra of the photoactive yellow protein (PYP) chromophore in vacuum, aqueous solution, and protein environments. The computed excitation energies of PYP require a very large QM region (hundreds of atoms) covalently bonded to the chromophore in order to achieve agreement with calculations that treat the entire protein quantum mechanically. We also show that 40 or more surrounding water molecules must be included in the QM region in order to obtain converged excitation energies of the solvated PYP chromophore. These results indicate that large QM regions (with hundreds of atoms) are a necessity in QM/MM calculations. PMID:23476156

  3. Clinical evaluation of surgery-induced astigmatism in cataract surgery using 2.2 mm or 1.8 mm clear corneal micro-incisions

    PubMed Central

    Yang, Jun; Wang, Xiu; Zhang, Hong; Pang, Yi; Wei, Rui-Hua

    2017-01-01

    AIM To evaluate corneal astigmatism after phacoemulsification using 2.2 mm or 1.8 mm clear corneal micro-incisions and its effects on visual function. METHODS Sixty cases (60 eyes) with cataract were randomly divided into groups A (n=30) and B (n=30) respectively underwent 2.2 mm and 1.8 mm clear corneal tunnel incision phacoemulsification combined with folding intraocular lens implantation from the time direction of 11:00. On day 1 and at 1, 4, and 6wk after operation, patients' vision was measured and both the corneal curvature and corneal thickness (CT) were recorded using Pentacam. RESULTS The measured surgery-induced astigmatism (SIA) in both groups A and B peaked on day 1 after operation, and then gradually decreased and eventually stabilized in week 4. No statistically significant difference was found in corneal astigmatism between two groups (P>0.05). The measured corneal astigmatism at 4wk and 6wk postoperatively were 0.28±0.09 D and 0.27±0.10 D for groups A and 0.27±0.09 D and 0.25±0.10 D for groups B without statistically significant difference (P>0.05). In addition, no significant differences in visual acuity and CT were found between groups A and B before or after operation. CONCLUSION Both 2.2 mm and 1.8 mm micro-incision cataract surgeries result in relatively small SIA with no difference in visual function and corneal astigmatism between two surgery approaches. Thus, the two types of surgical systems are safe and efficient for cataract treatment, by which satisfactory uncorrected visual acuity can be regained early postoperatively. PMID:28149779

  4. Toolmanagement - Werkzeuge und Prozesse als Schlüssel für eine effiziente Produktion

    NASA Astrophysics Data System (ADS)

    Enßle, Magnus

    In Bezug auf die Fertigungskosten nehmen die Werkzeugkosten mit 3% einen sehr kleinen und daher vermeintlich unwichtigen Posten ein. HoheKosten ergeben sich aber meist indirekt durch Maschinenstillstandszeiten wegen fehlender oder falscher Werkzeuge, wegen ineffektiven Rüstvorgängen, umständlicher Werkzeuglogistik, unnötig hoher Bestände, unabgestimmter Abläufe, nicht aktueller Fertigungsunterlagen sowie mangelhafter Informationsflüsse zwischen Planung, Vorbereitung und Ausführung in der Fertigung [1].

  5. Design und Analyse elektrisch kleiner Antennen für den Einsatz in UHF RFID Transpondern

    NASA Astrophysics Data System (ADS)

    Herschmann, R.; Camp, M.; Eul, H.

    2006-09-01

    RFID Systeme werden seit Anfang der neunziger Jahre mit stetig zunehmender Verbreitung im Bereich der automatischen Produktidentifikation, der Diebstahlsicherung (EAS, Electronic Article Surveillance) und für automatische Zutrittskontrollsysteme eingesetzt. Objekte werden hierzu mit einem Transponder ausgestattet, der aus einer Antenne und einem Chip auf einem Trägermaterial besteht. Von großem Interesse ist die Entwicklung und Optimierung von passiven Transpondern für den Einsatz in UHF RFID Systemen. Diese Transponder beziehen die Energie zum Betrieb des Chips aus dem elektromagnetischen Feld einer Schreib-Leseeinheit. Hierfür ist neben der Anpassung der Eingangsimpedanz der Antenne an die Chipimpedanz auch eine möglichst hohe Bandbreite der Antennen wünschenswert, um die Funktion des Transponders bei Schwankungen der Chipimpedanz und variablen Umgebungsparametern zu gewährleisten. Der aus Platzgründen notwendige Einsatz elektrisch kleiner Antennen bedingt eine möglichst optimale Ausnutzung der zur Verfügung stehenden Fläche auf dem Trägermaterial zur Aufnahme der Antenne. Die vorliegende Arbeit beschreibt ein Verfahren zur Analyse und Synthese neuartiger Antennendesigns auf der Basis parametrisierter meandrierter, spiralförmiger und logarithmisch periodischer Dipole.

  6. Schönheit und andere Provokationen - Eine neue evolutionsbiologische Theorie der Kunst

    NASA Astrophysics Data System (ADS)

    Junker, Thomas

    Die Evolution hat viele spektakuläre Phänomene hervorgebracht - von der Eleganz des Vogelflugs über die gigantischen Körper der Dinosaurier und die farbenprächtige Vielfalt der Korallenriffe bis hin zu ihrem jüngsten Geniestreich - der menschlichen Kunst. Die schönen Künste - Malerei, Bildhauerei und Architektur, Theater, Tanz, Oper und Filmkunst, Musik und Literatur - Produkte der Evolution? Diese Vorstellung mutet vielen Menschen fremd an, aber wie könnte es anders sein? Denn wenn Charles Darwin recht hat, dann sind nicht nur die körperlichen Merkmale der Menschen als Antworten auf die Erfordernisse des Lebens entstanden, sondern auch ihre geistigen Fähigkeiten und Verhaltensweisen. Im Jahr 1859 hatte er auf den letzten Seiten seines berühmten Buches über die Entstehung der Arten eine kühne Prophezeiung gemacht: Durch die Evolutionstheorie werde es "zu einer bemerkenswerten Revolution in der Naturwissenschaft kommen […]. Die Psychologie wird auf die neue Grundlage gestellt, dass jede geistige Kraft und Fähigkeit notwendigerweise durch graduelle Übergänge erworben wird“ (Darwin 1859, S. 484, 488; Junker 2008).

  7. Stricture Rate after Laparoscopic Roux-en-Y Gastric Bypass with a 21-mm Circular Stapler versus a 25-mm Linear Stapler

    PubMed Central

    Vunnamadala, Kalyan; Sakharpe, Aniket; Wilhelm, B. Jakub; Aksade, Artun

    2015-01-01

    Background: Obesity is estimated to affect more than one and a half billion adults. Laparoscopic Roux-en-Y gastric bypass (LRYGB) has become one of the preferred weight loss procedures. However, complications can occur. Strictures at the gastrojejunal anastomosis lead to clinical symptoms such as vomiting, dysphagia, and patient discomfort. The stricture rate has been correlated with the size and type of stapler used. Methods: A retrospective review of the clinical records of patients who underwent LRYGB was performed between 2003 and 2010. A comparison was made between a 21-mm circular stapler technique and a 25-mm linear stapler technique. Results: The stricture rate for the 21-mm circular stapler group was 7.12% and comparable to the national average. Using the 25-mm linear stapler, this complication rate significantly decreased to 1.09% (p<0.0004; odds ratio 6.5; [95% confidence interval 1.96–33.83]). Conclusions: Stricture after LRYGB is a serious complication. This study found that with a change in technique, this complication can be decreased considerably. PMID:25830078

  8. Estimation of the Young’s modulus of cellulose Iß by MM3 and quantum mechanics

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Young’s modulus provides a measure of the resistance to deformation of an elastic material. In this study, modulus estimations for models of cellulose Iß relied on calculations performed with molecular mechanics (MM) and quantum mechanics (QM) programs. MM computations used the second generation emp...

  9. Young’s modulus calculations for cellulose Iß by MM3 and quantum mechanics

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Quantum mechanics (QM) and molecular mechanics (MM) calculations were performed to elucidate Young’s moduli for a series of cellulose Iß models. Computations using the second generation empirical force field MM3 with a disaccharide cellulose model, 1,4'-O-dimethyl-ß-cellobioside (DMCB), and an analo...

  10. Toward QM/MM Simulation of Enzymatic Reactions with the Drude Oscillator Polarizable Force Field.

    PubMed

    Boulanger, Eliot; Thiel, Walter

    2014-04-08

    The polarization of the environment can influence the results from hybrid quantum mechanical/molecular mechanical (QM/MM) simulations of enzymatic reactions. In this article, we address several technical aspects in the development of polarizable QM/MM embedding using the Drude Oscillator (DO) force field. We propose a stable and converging update of the DO polarization state for geometry optimizations and a suitable treatment of the QM/MM-DO boundary when the QM and MM regions are separated by cutting through a covalent bond. We assess the performance of our approach by computing binding energies and geometries of three selected complexes relevant to biomolecular modeling, namely the water trimer, the N-methylacetamide dimer, and the cationic bis(benzene)sodium sandwich complex. Using a recently published MM-DO force field for proteins, we evaluate the effect of MM polarization on the QM/MM energy profiles of the enzymatic reactions catalyzed by chorismate mutase and by p-hydroxybenzoate hydroxylase. We find that inclusion of MM polarization affects the computed barriers by about 10%.

  11. The M/M Center: Meeting the Demand for Multicultural, Multilingual Teacher Preparation

    ERIC Educational Resources Information Center

    Wong, Pia Lindquist; Murai, Harold; Berta-Avila, Margarita; William-White, Lisa; Baker, Susan; Arellano, Adele; Echandia, Adriana

    2007-01-01

    The Multilingual/Multicultural Teacher Preparation Center (M/M Center), a teacher preparation program offered by the Bilingual/Multicultural Education Department (BMED) at California State University, Sacramento, is entering its third decade of operation. The M/M Center was established by a group of progressive teacher educators, most with a…

  12. An efficient method of measuring the 4 mm helmet output factor for the Gamma Knife

    NASA Astrophysics Data System (ADS)

    Ma, Lijun; Li, X. Allen; Yu, Cedric X.

    2000-03-01

    It is essential to have accurate measurements of the 4 mm helmet output factor in the treatment of trigeminal neuralgia patients using the Gamma Knife. Because of the small collimator size and the sharp dose gradient at the beam focus, this measurement is generally tedious and difficult. We have developed an efficient method of measuring the 4 mm helmet output factor using regular radiographic films. The helmet output factor was measured by exposing a single Kodak XV film in the standard Leksell spherical phantom using the 18 mm helmet with 30-40 of its plug collimators replaced by the 4 mm plug collimators. The 4 mm helmet output factor was measured to be 0.876 ± 0.009. This is in excellent agreement with our EGS4 Monte Carlo simulated value of 0.876 ± 0.005. This helmet output factor value also agrees with more tedious TLD, diode and radiochromic film measurements that were each obtained using two separate measurements with the 18 mm helmet and the 4 mm helmet respectively. The 4 mm helmet output factor measured by the diode was 0.884 ± 0.016, and the TLD measurement was 0.890 ± 0.020. The radiochromic film measured value was 0.870 ± 0.018. Because a single-exposure measurement was performed instead of a double-exposure measurement, most of the systematic errors that appeared in the double-exposure measurements due to experimental setup variations were cancelled out. Consequently, the 4 mm helmet output factor is more precisely determined by the single-exposure approach. Therefore, routine measurement and quality assurance of the 4 mm helmet output factor of the Gamma Knife could be efficiently carried out using the proposed single-exposure technique.

  13. dMM-PBSA: A New HADDOCK Scoring Function for Protein-Peptide Docking

    PubMed Central

    Spiliotopoulos, Dimitrios; Kastritis, Panagiotis L.; Melquiond, Adrien S. J.; Bonvin, Alexandre M. J. J.; Musco, Giovanna; Rocchia, Walter; Spitaleri, Andrea

    2016-01-01

    Molecular-docking programs coupled with suitable scoring functions are now established and very useful tools enabling computational chemists to rapidly screen large chemical databases and thereby to identify promising candidate compounds for further experimental processing. In a broader scenario, predicting binding affinity is one of the most critical and challenging components of computer-aided structure-based drug design. The development of a molecular docking scoring function which in principle could combine both features, namely ranking putative poses and predicting complex affinity, would be of paramount importance. Here, we systematically investigated the performance of the MM-PBSA approach, using two different Poisson–Boltzmann solvers (APBS and DelPhi), in the currently rising field of protein-peptide interactions (PPIs), identifying the correct binding conformations of 19 different protein-peptide complexes and predicting their binding free energies. First, we scored the decoy structures from HADDOCK calculation via the MM-PBSA approach in order to assess the capability of retrieving near-native poses in the best-scoring clusters and of evaluating the corresponding free energies of binding. MM-PBSA behaves well in finding the poses corresponding to the lowest binding free energy, however the built-in HADDOCK score shows a better performance. In order to improve the MM-PBSA-based scoring function, we dampened the MM-PBSA solvation and coulombic terms by 0.2, as proposed in the HADDOCK score and LIE approaches. The new dampened MM-PBSA (dMM-PBSA) outperforms the original MM-PBSA and ranks the decoys structures as the HADDOCK score does. Second, we found a good correlation between the dMM-PBSA and HADDOCK scores for the near-native clusters of each system and the experimental binding energies, respectively. Therefore, we propose a new scoring function, dMM-PBSA, to be used together with the built-in HADDOCK score in the context of protein-peptide docking

  14. Treatment of Pigmented Basal Cell Carcinoma with 3 mm Surgical Margin in Asians.

    PubMed

    Lin, Shang-Hung; Cheng, Yu-Wen; Yang, Yi-Chien; Ho, Ji-Chen; Lee, Chih-Hung

    2016-01-01

    Background. In Asians, most basal cell carcinomas (BCCs) are pigmented with clear borders. The consensus of 4 mm surgical margin for BCC largely depends on studies in nonpigmented BCCs in Caucasians. However, little is known about recurrences of pigmented BCCs with a narrower surgical margin. We aimed to investigate 5-year recurrence of BCCs, either pigmented or nonpigmented, in Taiwanese with 3 mm surgical margin. Materials and Methods. 143 patients with BCC (M/F = 66/77, average 64 years) were confirmed pathologically from 2002 to 2013. Based on the pathological margin (>1 mm, ≤1 mm, and involved), patients were categorized into the complete excision group (n = 77), histology with close proximity group (n = 43), and unclear surgical margin group (n = 23). Results. Among 143 cases, 105 were pigmented. With standard 3 mm excision, there were 7 recurrences, with 6 of them from nonpigmented BCC group. Logistic regression showed that pigmentation was associated with lower recurrence. Interestingly, 5-year recurrence of completely excised and histology with close proximity BCC (0/77 versus 1/43) was not different statistically. Conclusions. A 3 mm surgical margin is adequate for pigmented BCC. A "wait and see" approach rather than further wide excision is appropriate for BCC with <1 mm free margin.

  15. Toward Hamiltonian Adaptive QM/MM: Accurate Solvent Structures Using Many-Body Potentials.

    PubMed

    Boereboom, Jelle M; Potestio, Raffaello; Donadio, Davide; Bulo, Rosa E

    2016-08-09

    Adaptive quantum mechanical (QM)/molecular mechanical (MM) methods enable efficient molecular simulations of chemistry in solution. Reactive subregions are modeled with an accurate QM potential energy expression while the rest of the system is described in a more approximate manner (MM). As solvent molecules diffuse in and out of the reactive region, they are gradually included into (and excluded from) the QM expression. It would be desirable to model such a system with a single adaptive Hamiltonian, but thus far this has resulted in distorted structures at the boundary between the two regions. Solving this long outstanding problem will allow microcanonical adaptive QM/MM simulations that can be used to obtain vibrational spectra and dynamical properties. The difficulty lies in the complex QM potential energy expression, with a many-body expansion that contains higher order terms. Here, we outline a Hamiltonian adaptive multiscale scheme within the framework of many-body potentials. The adaptive expressions are entirely general, and complementary to all standard (nonadaptive) QM/MM embedding schemes available. We demonstrate the merit of our approach on a molecular system defined by two different MM potentials (MM/MM'). For the long-range interactions a numerical scheme is used (particle mesh Ewald), which yields energy expressions that are many-body in nature. Our Hamiltonian approach is the first to provide both energy conservation and the correct solvent structure everywhere in this system.

  16. The Herschel Multi-Tiered Extragalactic Survey: SPIRE-mm Photometric Redshifts

    NASA Technical Reports Server (NTRS)

    Roseboom, I. G.; Ivison, R. J.; Greve, T. R.; Amblard, A.; Arumugam, V.; Auld, R.; Aussel, H.; Bethermin, M.; Blain, A.; Bock, J.; Boselli, A.; Brisbin, D.; Buat, V.; Burgarella, D.; Castro-Rodriguez, N.; Cava, A.; Chanial, P.; Chapin, E.; Chapman, S.; Clements, D. L.; Conley, A.; Conversi, L.; Cooray, A.; Dowell, C. D.; Dwek, E.

    2011-01-01

    We investigate the potential of submm-mm and submm-mm-radio photometric red-shifts using a sample of mm-selected sources as seen at 250, 350 and 500 micrometers by the SPIRE instrument on Herschel. From a sample of 63 previously identified mm-sources with reliable radio identifications in the GOODS-N and Lockman Hole North fields 46 (73 per cent) are found to have detections in at least one SPIRE band. We explore the observed submm/mm colour evolution with redshift, finding that the colours of mm-sources are adequately described by a modified blackbody with constant optical depth Tau = (nu/nu(0))beta where beta = +1.8 and nu(0) = c/100 micrometers. We find a tight correlation between dust temperature and IR luminosity. Using a single model of the dust temperature and IR luminosity relation we derive photometric redshift estimates for the 46 SPIRE detected mm-sources. Testing against the 22 sources with known spectroscopic, or good quality optical/near-IR photometric, redshifts we find submm/mm photometric redshifts offer a redshift accuracy of |delta z|/(1+z) = 0.16 (less than |delta z| greater than = 0.51). Including constraints from the radio-far IR correlation the accuracy is improved to |delta z|/(1 + z) = 0.15 (less than |delta z| greater than = 0.45). We estimate the redshift distribution of mm-selected sources finding a significant excess at z greater than 3 when compared to 850 micrometer selected samples.

  17. The Herschel Multi-Tiered Extragalactic Survey: SPIRE-mm Photometric Redshifts

    NASA Technical Reports Server (NTRS)

    Roseboom, I. G.; Ivison, R. J.; Greve, T. R.; Amblard, A.; Arumugam, V.; Auld, R.; Aussel, H.; Bethermin, M.; Blain, A.; Block, J.; Boselli, A.; Brisbin, D.; Buat, V.; Burgarella, D.; Castro-Rodriquez, N.; Cava, A.; Chanial, P.; Chapin, E.; Chapman, S.; Clements, D. L.; Conley, A.; Conversi, L.; Dowell, C. D.; Dunlop, J. S.; Dwek, E.

    2012-01-01

    We investigate the potential of submm-mm and submm-mm-radio photometric redshifts using a sample of mm-selected sources as seen at 250, 350 and 500 micron by the SPIRE instrument on Herschel. From a sample of 63 previously identified mm sources with reliable radio identifications in the Great Observatories Origins Deep Survey North and Lockman Hole North fields, 46 (73 per cent) are found to have detections in at least one SPIRE band. We explore the observed submm/mm color evolution with redshift, finding that the colors of mm sources are adequately described by a modified blackbody with constant optical depth Tau = (Nu/nu(sub 0))(exp Beta), where Beta = +1.8 and nu(sub 0) = c/100 micron. We find a tight correlation between dust temperature and IR luminosity. Using a single model of the dust temperature and IR luminosity relation, we derive photometric redshift estimates for the 46 SPIRE-detected mm sources. Testing against the 22 sources with known spectroscopic or good quality optical/near-IR photometric redshifts, we find submm/mm photometric redshifts offer a redshift accuracy of (absolute value of Delta sub (z))/(1 + z) = 0.16 (absolute value of Delta sub (z)) = 0.51). Including constraints from the radio-far-IR correlation, the accuracy is improved to (absolute value of Delta sub (z))/(1 + z) = 0.14 (((absolute value of Delta sub (z))) = 0.45). We estimate the redshift distribution of mm-selected sources finding a significant excess at Z > 3 when compared to approx 8S0 micron selected samples.

  18. G11.92–0.61-MM2: A BONAFIDE MASSIVE PRESTELLAR CORE?

    SciTech Connect

    Cyganowski, C. J.; Brogan, C. L.; Hunter, T. R.; Schnee, S.; Graninger, D.; Öberg, K. I.; Zhang, Q.; Vasyunin, A.; Friesen, R.

    2014-11-20

    Core accretion models of massive star formation require the existence of stable massive starless cores, but robust observational examples of such objects have proven elusive. We report subarcsecond-resolution Submillimeter Array (SMA) 1.3 mm, 1.1 mm, and 0.88 mm and Very Large Array 1.3 cm observations of an excellent massive starless core candidate, G11.92–0.61-MM2, initially identified in the course of studies of GLIMPSE Extended Green Objects (EGOs). Separated by ∼7.''2 from the nearby MM1 protostellar hot core, MM2 is a strong, compact dust continuum source (submillimeter spectral index α = 2.6 ± 0.1), but is devoid of star formation indicators. In contrast to MM1, MM2 has no masers, no centimeter continuum, and no (sub)millimeter wavelength line emission in ∼24 GHz of bandwidth observed with the SMA, including N{sub 2}H{sup +}(3-2), HCO{sup +}(3-2), and HCN(3-2). Additionally, there is no evidence for an outflow driven by MM2. The (sub)millimeter spectral energy distribution of MM2 is best fit with a dust temperature of ∼17-19 K and luminosity of ∼5-7 L {sub ☉}. The combined physical properties of MM2, as inferred from its dust continuum emission, are extreme: M ≳ 30 M {sub ☉} within a radius <1000 AU, N{sub H{sub 2}}>10{sup 25} cm{sup –2} and n{sub H{sub 2}} >10{sup 9} cm{sup –3}. Comparison of the molecular abundance limits derived from our SMA observations with gas-grain chemical models indicates that extremely dense (n(H) >> 10{sup 8} cm{sup –3}), cold (<20 K) conditions are required to explain the lack of observed (sub)millimeter line emission, consistent with the dust continuum results. Our data suggest that G11.92–0.61-MM2 is the best candidate for a bonafide massive prestellar core found to date, and a promising target for future higher-sensitivity observations.

  19. Fragwuerdige Luxussteuern: Statusstreben und Demonstratives Konsumverhalten in der Geschichte Oekonomischen Denkens (Questionable Luxury Taxes: Status Seeking and Conspicuous Consumption in the History of Economic Thought)

    DTIC Science & Technology

    2008-05-01

    England immer mehr, und der Markt ffir Luxusgiiter und Mode begann zu florieren. Die Kommerzialisierung des Handels im England des 18. Jahrhunderts...der insbesondere Hirsch (1976) in seinen Social Limits to Growth wieder Nachdruck verleihen sollte. Siehe hierzu Abschnitt 2.9. 5 auf seinen...klassischen Schule ibertriebenes statusbedingtes Konsumverhalten als social waste an und pladiert fdr eine Lenkung statusbedingten Konsumverhaltens in

  20. Video-Assisted Thoracoscopic Surgery for Correction of Adolescent Idiopatic Scoliosis: Comparison of 4.5 mm versus 5.5 mm Rod Constructs

    PubMed Central

    Kim, Hak Sun; Park, Jin Oh; Nanda, Ankur; Kho, Phillip Anthony; Kim, Jin Young; Lee, Hwan Mo; Moon, Seong Hwan; Ha, Jung Won; Ahn, Eun Kyoung; Shin, Dong Eun; Kim, Sung Jun

    2010-01-01

    Purpose The purpose of this study is to report the comparative results of thoracoscopic correction achieved via cantilever technique using a 4.5 mm thin rod and the poly-axial reduction screw technique using a 5.5 mm thick rod in Lenke type 1 adolescent idiopathic scoliosis (AIS). Materials and Methods Radiographic data, Scoliosis Research Society (SRS) patient-based outcome questionnaires, and operative records were reviewed for forty-nine patients undergoing surgical treatment of scoliosis. The study group was divided into a 4.5 mm thin rod group (n = 24) and a 5.5 mm thick rod group (n = 25). The radiographic parameters that were analyzed included coronal curve correction, the most caudal instrumented vertebra tilt angle correction, coronal balance, and thoracic kyphosis. Results The major curve was corrected from 49.8° and 47.2° pre-operatively to 24.5° and 18.8° at the final follow-up for the thin and thick rod groups, respectively (50.8% vs. 60.2% correction). There were no significant differences between the two groups in terms of kyphosis, coronal balance, or tilt angle at the time of the final follow-up. The mean number of levels fused was 6.2 in the thin rod group, compared with 5.9 levels in the thick rod group. There were no major intraoperative complications in either group. Conclusion Significant correction loss was observed in the thin rod system at the final follow-up though both groups had comparable correction immediately post-operative. Therefore, the thick rod with poly axial screw system helps to maintain post-operative correction. PMID:20635452

  1. Assessment of Bite Force in Patients Treated with 2.0-mm Traditional Miniplates versus 2.0-mm Locking Plates for Mandibular Fracture

    PubMed Central

    Rastogi, Sanjay; Reddy, Mahendra Parvath; Swarup, Azeez Gaurav; Swarup, Divya; Choudhury, Rupshikha

    2015-01-01

    The objective of this study is to analyze the difference in bite forces in patients treated for mandibular fractures with 2.0 mm conventional and locking titanium plating system. A randomized study was performed for the treatment of fractures of mandible. In this study, 20 adult patients with isolated mandibular fracture were included. The patients were randomly allocated into two groups, that is, Group I—2.0 mm nonlocking (traditional) and Group II—2.0 mm locking plates. Bite force was evaluated at 1st, 3rd, and 6th weeks. Comparison of all the assessed parameters between both the groups depicted no significant difference in terms of pain, swelling including the incidence of infection, paresthesia, and hardware failure. Although same was true in case of bite force between both the groups at various time intervals, there was statistically significant increase in the bite force within the group comprising patients in whom locking plates was used between 1st and 3rd weeks follow-up period and highly significant increase in bite force between 1st and 6th weeks of follow-up period. The rapid improvement of bite force values when locking plates were used implies that the locking plate can be used in preference to conventional plates to achieve early mobilization with assured stability in the treatment of mandibular fractures. PMID:26889350

  2. Oesophageal heat exchangers with a diameter of 11mm or 14.7mm are equally effective and safe for targeted temperature management

    PubMed Central

    Guschlbauer, Maria; Maul, Alexandra C.; Cremer, Daniel A.; Becker, Ingrid; de la Puente Bethencourt, David; Paal, Peter; Padosch, Stephan A.; Wetsch, Wolfgang A.; Annecke, Thorsten; Böttiger, Bernd W.; Sterner-Kock, Anja; Herff, Holger

    2017-01-01

    Background Targeted temperature management (TTM) is widely used in critical care settings for conditions including hepatic encephalopathy, hypoxic ischemic encephalopathy, meningitis, myocardial infarction, paediatric cardiac arrest, spinal cord injury, traumatic brain injury, ischemic stroke and sepsis. Furthermore, TTM is a key treatment for patients after out-of-hospital cardiac-arrest (OHCA). However, the optimal cooling method, which is quick, safe and cost-effective still remains controversial. Since the oesophagus is adjacent to heart and aorta, fast heat-convection to the central blood-stream could be achieved with a minimally invasive oesophageal heat exchanger (OHE). To date, the optimal diameter of an OHE is still unknown. While larger diameters may cause thermal- or pressure-related tissue damage after long-term exposure to the oesophageal wall, smaller diameter (e.g., gastric tubes, up to 11mm) may not provide effective cooling rates. Thus, the objective of the study was to compare OHE-diameters of 11mm (OHE11) and 14.7mm (OHE14.7) and their effects on tissue and cooling capability. Methods Pigs were randomized to OHE11 (N = 8) or OHE14.7 (N = 8). After cooling, pigs were maintained at 33°C for 1 hour. After 10h rewarming, oesophagi were analyzed by means of histopathology. The oesophagus of four animals from a separate study that underwent exactly the identical preparation and cooling protocol described above but received a maintenance period of 24h were used as histopathological controls. Results Mean cooling rates were 2.8±0.4°C°C/h (OHE11) and 3.0±0.3°C °C/h (OHE14.7; p = 0.20). Occasional mild acute inflammatory transepithelial infiltrates were found in the cranial segment of the oesophagus in all groups including controls. Deviations from target temperature were 0.1±0.4°C (OHE11) and 0±0.1°C (OHE14.7; p = 0.91). Rewarming rates were 0.19±0.07°C °C/h (OHE11) and 0.20±0.05°C °C/h (OHE14.7; p = 0.75). Conclusions OHE with diameters

  3. Same-source parallel implementation of the PSU/NCAR MM5

    SciTech Connect

    Michalakes, J.

    1997-12-31

    The Pennsylvania State/National Center for Atmospheric Research Mesoscale Model is a limited-area model of atmospheric systems, now in its fifth generation, MM5. Designed and maintained for vector and shared-memory parallel architectures, the official version of MM5 does not run on message-passing distributed memory (DM) parallel computers. The authors describe a same-source parallel implementation of the PSU/NCAR MM5 using FLIC, the Fortran Loop and Index Converter. The resulting source is nearly line-for-line identical with the original source code. The result is an efficient distributed memory parallel option to MM5 that can be seamlessly integrated into the official version.

  4. MM1+2C sporadic Creutzfeldt-Jakob disease presenting as rapidly progressive nonfluent aphasia.

    PubMed

    Allegri, Ricardo F; Bartoloni, Leonardo; Iturry, Mónica; Romero, Carlos; Begué, Christián; Sevlever, Gustavo; Taratuto, Ana Lía

    2014-01-01

    We report a 77-year-old man, presenting with progressive aphasia as an initial symptom, who developed severe dementia over the course of 20 months. Frontal cortex PrPSc western blot was type 2 and codon 129 was MM; brain neuropathology showed cortical vacuoles with perivacuolar PrP immunostaining characteristic of MM2C. Cerebellum showed focal coarse, patchy staining in different sections of the molecular layer, diffuse fine punctuate and coarse PrP immunopositive deposits in the granule cell layer, and focal synaptic immunostaining in the molecular layer, suggestive of MM1+2C by histotyping. This clinical presentation has not yet been described in an MM1+2C subtype by histotyping.

  5. Parameters of tensile strength, elongation, and tenacity of 70mm IIaO spectroscopic film

    NASA Astrophysics Data System (ADS)

    Hammond, Ernest C., Jr.; Peters, Kevin A.

    The 70mm IIaO spectroscopic film was tested to determine its tensile strength, elongation, and breaking strength, using an Instron (strength and compression) 4201 Test Instrument. These data provide information leading to the upper and lower limits of the above parameters for 70mm IIaO spectroscopic film. This film will be developed by a commercial developing machine after the Ultraviolet Telescope Space Shuttle Mission returns to the Earth in the early 1990's; thus, it is necessary to understand these force parameters. Several test strips of approximately 200mm in length were used. The results indicate that when a stress load of 100 kg was applied, the film elongated approximately 1.06mm and the break strength was 19.45 kilograms.

  6. Parameters of tensile strength, elongation, and tenacity of 70mm IIaO spectroscopic film

    NASA Technical Reports Server (NTRS)

    Hammond, Ernest C., Jr.; Peters, Kevin A.

    1989-01-01

    The 70mm IIaO spectroscopic film was tested to determine its tensile strength, elongation, and breaking strength, using an Instron (strength and compression) 4201 Test Instrument. These data provide information leading to the upper and lower limits of the above parameters for 70mm IIaO spectroscopic film. This film will be developed by a commercial developing machine after the Ultraviolet Telescope Space Shuttle Mission returns to the Earth in the early 1990's; thus, it is necessary to understand these force parameters. Several test strips of approximately 200mm in length were used. The results indicate that when a stress load of 100 kg was applied, the film elongated approximately 1.06mm and the break strength was 19.45 kilograms.

  7. 480mm telephoto perspective, looking south toward midspan and south anchor ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    480-mm telephoto perspective, looking south toward mid-span and south anchor arm. - Pittsburgh & Lake Erie Railroad, Ohio River Bridge, Spanning Ohio River, West of Beaver River, Beaver, Beaver County, PA

  8. 480mm telephoto perpective, looking south toward midspan and south anchor ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    480-mm telephoto perpective, looking south toward mid-span and south anchor arm. - Pittsburgh & Lake Erie Railroad, Ohio River Bridge, Spanning Ohio River, West of Beaver River, Beaver, Beaver County, PA

  9. Solvents effects on the mechanism of cellulose hydrolysis: A QM/MM study.

    PubMed

    Loerbroks, Claudia; Heimermann, Andreas; Thiel, Walter

    2015-06-05

    This article reports a combined quantum mechanics/molecular mechanics (QM/MM) investigation on the acid hydrolysis of cellulose in water using two different models, cellobiose and a 40-unit cellulose chain. The explicitly treated solvent molecules strongly influence the conformations, intramolecular hydrogen bonds, and exoanomeric effects in these models. As these features are largely responsible for the barrier to cellulose hydrolysis, the present QM/MM results for the pathways and reaction intermediates in water are expected to be more realistic than those from a former density functional theory (DFT) study with implicit solvent (CPCM). However, in a qualitative sense, there is reasonable agreement between the DFT/CPCM and QM/MM predictions for the reaction mechanism. Differences arise mainly from specific solute-solvent hydrogen bonds that are only captured by QM/MM and not by DFT/CPCM.

  10. 7. Detail, east portal of Tunnel 34/Snowshed 33, 135mm lens. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Detail, east portal of Tunnel 34/Snowshed 33, 135mm lens. Tall signal mast necessary in order to be seen above winter snows. - Central Pacific Transcontinental Railroad, Tunnel No. 41, Milepost 193.3, Donner, Placer County, CA

  11. 5. East portal of Tunnel 26, view to southwest, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. East portal of Tunnel 26, view to southwest, 135mm lens. Tunnel 25 (HAER CA-201) is visible in the distance. - Central Pacific Transcontinental Railroad, Tunnel No. 26, Milepost 133.29, Applegate, Placer County, CA

  12. A new smoothing function to introduce long-range electrostatic effects in QM/MM calculations

    SciTech Connect

    Fang, Dong; Duke, Robert E.; Andrés Cisneros, G.

    2015-07-28

    A new method to account for long range electrostatic contributions is proposed and implemented for quantum mechanics/molecular mechanics long range electrostatic correction (QM/MM-LREC) calculations. This method involves the use of the minimum image convention under periodic boundary conditions and a new smoothing function for energies and forces at the cutoff boundary for the Coulomb interactions. Compared to conventional QM/MM calculations without long-range electrostatic corrections, the new method effectively includes effects on the MM environment in the primary image from its replicas in the neighborhood. QM/MM-LREC offers three useful features including the avoidance of calculations in reciprocal space (k-space), with the concomitant avoidance of having to reproduce (analytically or approximately) the QM charge density in k-space, and the straightforward availability of analytical Hessians. The new method is tested and compared with results from smooth particle mesh Ewald (PME) for three systems including a box of neat water, a double proton transfer reaction, and the geometry optimization of the critical point structures for the rate limiting step of the DNA dealkylase AlkB. As with other smoothing or shifting functions, relatively large cutoffs are necessary to achieve comparable accuracy with PME. For the double-proton transfer reaction, the use of a 22 Å cutoff shows a close reaction energy profile and geometries of stationary structures with QM/MM-LREC compared to conventional QM/MM with no truncation. Geometry optimization of stationary structures for the hydrogen abstraction step by AlkB shows some differences between QM/MM-LREC and the conventional QM/MM. These differences underscore the necessity of the inclusion of the long-range electrostatic contribution.

  13. Feasibility Tests for 400m Offset Zeroing the 25mm Gun of the Bradley Fighting Vehicle

    DTIC Science & Technology

    1988-07-01

    Bradley Fighting Vehicle 12. PERSONAL AUTHOR(S) Perkins, Mike S. ; and Wilkinson, Craig S. (Litton Computer Services Div., Litton Systems, Inc.) 13a...number) FIELD GROUP SUB-GROUP 25mm automatic gurn M242C , Bradley Fighting Vehicle/ I Zeroing. 19. ABSTRACT (Continue on reverse if necessary and identify...by block number) --> Researchers developed a short-range zeroing procedure and target for the Bradley Fighting Vehicle’s 25mm gun to minimize the

  14. Techniques and Procedures to Improve 25mm Gunnery of the Bradley Fighting Vehicle

    DTIC Science & Technology

    1988-10-01

    Gunnery of the Bradley Fighting Vehicle DTIC Mike S. Perkins F I-ECTE Litton Computer Services Division SEP 07 1989 Litton Systems, Inc. October 1988...Classification, Techniques and Procedures to Improve 25mm Gunnery of the Bradley Fighting Vehicle 12. PERSONAL AUTHOR(S) Perkins, Mike S. (Litton Computer...Research has been conducted to develop and evaluate procedures and techniques to im- prove 25mm gunnery of the Bradley Fighting Vehicle OB1RV)P. The

  15. A new smoothing function to introduce long-range electrostatic effects in QM/MM calculations.

    PubMed

    Fang, Dong; Duke, Robert E; Cisneros, G Andrés

    2015-07-28

    A new method to account for long range electrostatic contributions is proposed and implemented for quantum mechanics/molecular mechanics long range electrostatic correction (QM/MM-LREC) calculations. This method involves the use of the minimum image convention under periodic boundary conditions and a new smoothing function for energies and forces at the cutoff boundary for the Coulomb interactions. Compared to conventional QM/MM calculations without long-range electrostatic corrections, the new method effectively includes effects on the MM environment in the primary image from its replicas in the neighborhood. QM/MM-LREC offers three useful features including the avoidance of calculations in reciprocal space (k-space), with the concomitant avoidance of having to reproduce (analytically or approximately) the QM charge density in k-space, and the straightforward availability of analytical Hessians. The new method is tested and compared with results from smooth particle mesh Ewald (PME) for three systems including a box of neat water, a double proton transfer reaction, and the geometry optimization of the critical point structures for the rate limiting step of the DNA dealkylase AlkB. As with other smoothing or shifting functions, relatively large cutoffs are necessary to achieve comparable accuracy with PME. For the double-proton transfer reaction, the use of a 22 Å cutoff shows a close reaction energy profile and geometries of stationary structures with QM/MM-LREC compared to conventional QM/MM with no truncation. Geometry optimization of stationary structures for the hydrogen abstraction step by AlkB shows some differences between QM/MM-LREC and the conventional QM/MM. These differences underscore the necessity of the inclusion of the long-range electrostatic contribution.

  16. Optical design and evaluation of a 4 mm cost-effective ultra-high-definition arthroscope.

    PubMed

    Cheng, Dewen; Wang, Yongtian; Yu, Lu; Liu, Xiaohua

    2014-08-01

    High definition and magnification rigid endoscope plays an important role in modern minimally invasive medical surgery and diagnosis. In this paper, we present the design and evaluation methods of a high definition rigid endoscope, specifically an arthroscope, with a large depth of field (DOF). The incident heights and exit angles of the sampled rays on the relay lens are controlled during the optimization process to ensure an effective field view (70°) and a normal ray path within the limited lens diameter of 2.7 mm. The lens is set up as a multi-configuration system with two extreme and one middle object distances to cover a large DOF. As a result, an entrance pupil of 0.3 mm is achieved for the first time, to bring the theoretical resolution to 23.1 lps/mm in the object space at a working distance of 20 mm, with the wavelength of 0.532 um. The modulation transfer function (MTF) curves approach diffraction limit, and the values are all higher than 0.3 at 160 line pairs/mm (lps/mm) in the image space. Meanwhile, stray light caused by total internal reflection on the inner wall of the rod lenses and the objective lens is eliminated. The measured resolution in the object space at a 20 mm working distance is 22.3 lps/mm, and test results show that other performance characteristics also fulfill design requirements. The relay lenses are designed with only one type of the spacer and two types of lenses to greatly reduce the fabrication and assembly cost. The design method has important research and application values for lens systems used in modern minimally invasive medical surgery and industrial non-destructive testing area.

  17. Morphological evaluation of eccentric sets guide-plates of dcp-l 4.5 mm

    PubMed Central

    Borges, José Humberto de Souza; da Silva Filho, Antonio Lisboa; Pereira Neto, Francisco; Daher, Walter Rodrigo; de Mesquita, Alessandro Queiroz; Freitas, Anderson

    2012-01-01

    Objective To carry out isolated and comparative evaluations of the measurements of the set eccentric guide plates used in 4.5mm surgical implants, and to determine the effect of these measurements on compression strength. Methods Four eccentric guides, four large dynamic compression plates (L-DCP) from four local manufacturers, and a Vonder® 200 mm caliper brand were used. Five standard parameter measurements were created for the set eccentric guide-plate, which were identified as A to E. Four sets were made, using materials of the same factory, and identified as groups I to IV. The analyses were performed by measuring all the parameters from a ventral view of the plate, with the eccentric guide placed in the plate hole. Results Groups I and II showed the same values for all the parameters. All the groups showed the same measurements for E = 8.15 e B = 3.60. Group III: A = 8.10mm, C = 3.25mm, D = 1.25mm. Group IV: A = 7.00mm, C = 3.10mm, D = 0.30mm. Maximum compression force was (F Max.): Group I 80.58 N, Group. II: F Max. 81.63 N, Group. III: F Max. 36.32N, Group. IV: F Max. 37.52N Conclusion The measurements evaluated show a lack of standardization in the manufacture of orthopedic instruments and its effects on the values for compression strength. Level of Evidence: Level III, analytical study. PMID:24453573

  18. ALMA 1.3 mm Observation of the Fomalhaut Debris Disk

    NASA Astrophysics Data System (ADS)

    White, Jacob; Boley, Aaron C.; Ford, Eric B.; Payne, Matthew J.; Dent, William; Corder, Stuartt

    2017-01-01

    We present ALMA Band 6 (1.3 mm) observations of Fomalhaut and its debris disk. Since the system is relatively close at 7.7 pc, it has been the target of numerous studies at multiple wavelengths, and can serve as a testbed for debris disk evolution models and planet-disk interactions. Outstanding issues that need to be resolved to properly characterize the debris include tightening constraints on the spectral index in the submm/mm regime and determining whether there is indeed excess over the stellar emission, indicating the presence of an inner debris disk or ring.These ALMA 1.3 mm observations provide the highest resolution observations to date of the mm grains the outer ring. Tight constraints are placed on the geometry of the disk and on the mm-wavelength spectral index. We explore fitting the debris disk model in the image plane in addition to the standard method of fitting the visibilities. The results are compared and potential advantages/disadvantages of each approach are discussed.The central emission detected is indistinguishable from a point source, with 0.90 mJy being the best fit flux of the host star for Fomalhaut itself. This implies that any inner debris component must contribute little to the total central emission. Moreover, the stellar flux is less than 70% of that predicted by extrapolating a blackbody from the constrained photosphere temperature and just over 70% of the flux if extrapolating from the far infrared. This behavior is similar to that seen in the Sun for submm/mm wavelengths, but even more pronounced. Currently, insufficient data exists to properly constrain the degree to which stellar atmospheres affect the observed flux in the submm/mm regime. This result is part of an ongoing larger project focused on measuring the emission from stellar atmospheres at submm/mm wavelengths, which directly impacts inferred excesses for debris disk studies.

  19. Optical design and evaluation of a 4 mm cost-effective ultra-high-definition arthroscope

    PubMed Central

    Cheng, Dewen; Wang, Yongtian; Yu, Lu; Liu, Xiaohua

    2014-01-01

    High definition and magnification rigid endoscope plays an important role in modern minimally invasive medical surgery and diagnosis. In this paper, we present the design and evaluation methods of a high definition rigid endoscope, specifically an arthroscope, with a large depth of field (DOF). The incident heights and exit angles of the sampled rays on the relay lens are controlled during the optimization process to ensure an effective field view (70°) and a normal ray path within the limited lens diameter of 2.7 mm. The lens is set up as a multi-configuration system with two extreme and one middle object distances to cover a large DOF. As a result, an entrance pupil of 0.3 mm is achieved for the first time, to bring the theoretical resolution to 23.1 lps/mm in the object space at a working distance of 20 mm, with the wavelength of 0.532 um. The modulation transfer function (MTF) curves approach diffraction limit, and the values are all higher than 0.3 at 160 line pairs/mm (lps/mm) in the image space. Meanwhile, stray light caused by total internal reflection on the inner wall of the rod lenses and the objective lens is eliminated. The measured resolution in the object space at a 20 mm working distance is 22.3 lps/mm, and test results show that other performance characteristics also fulfill design requirements. The relay lenses are designed with only one type of the spacer and two types of lenses to greatly reduce the fabrication and assembly cost. The design method has important research and application values for lens systems used in modern minimally invasive medical surgery and industrial non-destructive testing area. PMID:25136495

  20. SSC 50 mm collider dipole cryostat single tube support post conceptual design and analysis

    SciTech Connect

    Nicol, T.H.

    1992-04-01

    This report describes the conceptual design for a support post whose function is identical to that of the current reentrant design, which requires very few modifications to surrounding cryostat components, is thermally equivalent to the current 50 mm support post, and is nearly equivalent structurally. The focus of this work is on a design aimed specifically at application in SSC 50 mm collider dipoles, however, the conceptual design presented here is applicable to other cryogenic systems.

  1. A new smoothing function to introduce long-range electrostatic effects in QM/MM calculations

    NASA Astrophysics Data System (ADS)

    Fang, Dong; Duke, Robert E.; Cisneros, G. Andrés

    2015-07-01

    A new method to account for long range electrostatic contributions is proposed and implemented for quantum mechanics/molecular mechanics long range electrostatic correction (QM/MM-LREC) calculations. This method involves the use of the minimum image convention under periodic boundary conditions and a new smoothing function for energies and forces at the cutoff boundary for the Coulomb interactions. Compared to conventional QM/MM calculations without long-range electrostatic corrections, the new method effectively includes effects on the MM environment in the primary image from its replicas in the neighborhood. QM/MM-LREC offers three useful features including the avoidance of calculations in reciprocal space (k-space), with the concomitant avoidance of having to reproduce (analytically or approximately) the QM charge density in k-space, and the straightforward availability of analytical Hessians. The new method is tested and compared with results from smooth particle mesh Ewald (PME) for three systems including a box of neat water, a double proton transfer reaction, and the geometry optimization of the critical point structures for the rate limiting step of the DNA dealkylase AlkB. As with other smoothing or shifting functions, relatively large cutoffs are necessary to achieve comparable accuracy with PME. For the double-proton transfer reaction, the use of a 22 Å cutoff shows a close reaction energy profile and geometries of stationary structures with QM/MM-LREC compared to conventional QM/MM with no truncation. Geometry optimization of stationary structures for the hydrogen abstraction step by AlkB shows some differences between QM/MM-LREC and the conventional QM/MM. These differences underscore the necessity of the inclusion of the long-range electrostatic contribution.

  2. Accuracy of buffered-force QM/MM simulations of silica

    SciTech Connect

    Peguiron, Anke; Moras, Gianpietro; Colombi Ciacchi, Lucio; De Vita, Alessandro; Kermode, James R.

    2015-02-14

    We report comparisons between energy-based quantum mechanics/molecular mechanics (QM/MM) and buffered force-based QM/MM simulations in silica. Local quantities—such as density of states, charges, forces, and geometries—calculated with both QM/MM approaches are compared to the results of full QM simulations. We find the length scale over which forces computed using a finite QM region converge to reference values obtained in full quantum-mechanical calculations is ∼10 Å rather than the ∼5 Å previously reported for covalent materials such as silicon. Electrostatic embedding of the QM region in the surrounding classical point charges gives only a minor contribution to the force convergence. While the energy-based approach provides accurate results in geometry optimizations of point defects, we find that the removal of large force errors at the QM/MM boundary provided by the buffered force-based scheme is necessary for accurate constrained geometry optimizations where Si–O bonds are elongated and for finite-temperature molecular dynamics simulations of crack propagation. Moreover, the buffered approach allows for more flexibility, since special-purpose QM/MM coupling terms that link QM and MM atoms are not required and the region that is treated at the QM level can be adaptively redefined during the course of a dynamical simulation.

  3. fireball/amber: An Efficient Local-Orbital DFT QM/MM Method for Biomolecular Systems.

    PubMed

    Mendieta-Moreno, Jesús I; Walker, Ross C; Lewis, James P; Gómez-Puertas, Paulino; Mendieta, Jesús; Ortega, José

    2014-05-13

    In recent years, quantum mechanics/molecular mechanics (QM/MM) methods have become an important computational tool for the study of chemical reactions and other processes in biomolecular systems. In the QM/MM technique, the active region is described by means of QM calculations, while the remainder of the system is described using a MM approach. Because of the complexity of biomolecules and the desire to achieve converged sampling, it is important that the QM method presents a good balance between accuracy and computational efficiency. Here, we report on the implementation of a QM/MM technique that combines a DFT approach specially designed for the study of complex systems using first-principles molecular dynamics simulations (fireball) with the amber force fields and simulation programs. We also present examples of the application of this QM/MM approach to three representative biomolecular systems: the analysis of the effect of electrostatic embedding in the behavior of a salt bridge between an aspartic acid and a lysine residue, a study of the intermediate states for the triosephosphate isomerase catalyzed conversion of dihydroxyacetone phosphate into glyceraldehyde 3-phosphate, and the detailed description, using DFT QM/MM molecular dynamics, of the cleavage of a phosphodiester bond in RNA catalyzed by the enzyme RNase A.

  4. Die Tabellen von Ulugh Beg. Die Sternkataloge des Ptolemäus, Ulugh Beg und Tycho Brahe im Vergleich

    NASA Astrophysics Data System (ADS)

    Schwan, Heiner

    2002-09-01

    Im 15. Jahrhundert schuf Ulugh Beg, der Herrscher von Samarkand (1394 - 1449), ein wichtiges Tabellenwerk. Das Kernstück dieses Werks (Zij Ulugh Beg, "Tabellen Ulugh Begs") ist ein Katalog mit 1018 Sternen, ihren Helligkeiten und Positionen. In diesem Bericht werden die Zij Ulugh Beg mit den großen Katalogen von Ptolemäus und Tycho Brahe verglichen.

  5. Die Deutsche Statistische Gesellschaft in der Weimarer Republik und während der Nazidiktatur

    NASA Astrophysics Data System (ADS)

    Wilke, Jürgen

    Nach anfänglichen Schwierigkeiten durch den 1. Weltkrieg erlangte die Deutsche Statistische Gesellschaft (DStatG) unter dem renommierten Statistiker und Vorsitzenden der DStatG, Friedrich Zahn, durch eine Vielzahl von Aktivitäten hohes Ansehen. Es gab Bestrebungen, Statistiker aus allen Arbeitsfeldern der Statistik in die DStatG zu integrieren, wobei die "Mathematische Statistik" nur zögerlich akzeptiert wurde (Konjunkturforschung, Zeitreihenanalyse). Nach der Machtübernahme 1933 durch Adolf Hitler geriet die DStatG in das Fahrwasser nationalsozialistischer Ideologie und Politik (Führerprinzip, Gleichschaltung des Vereinswesens). Damit war eine personelle Umstrukturierung in der DStatG verbunden. Politisch Missliebige und rassisch Verfolgte mussten die DStatG verlassen (Bernstein, Freudenberg, Gumbel u.a.). Unter den Statistikern gab es alle Abstufungen im Verhalten zum Regime von Ablehnung und zwangsweiser Anpassung über bereitwilliges Mitläufertum bis zu bewusster Täterschaft. Besonders die Bevölkerungsstatistik wurde durch die NS- Rassenpolitik auf lange Sicht diskreditiert. Im Rahmen von Wirtschaftsplanung und Aufrüstung wurden neue zukunftsträchtige statistische Modelle (Grünig, Bramstedt, Leisse) entwickelt.

  6. Missbrauchspotential von Verzeichnisdienst-Metadaten in LDAP-basierten System- und Benutzerverwaltungen

    NASA Astrophysics Data System (ADS)

    Pluta, Daniel

    Metadaten stellen Zusatzinformationen über elektronisch gespeicherte Kerninformationen zur Verfügung. Sie ergänzen die eigentliche Hauptinformation um nützliche Details. In vielen Bereichen werden Metadaten gespeichert und stehen zur Auswertung zur Verfügung. Alle IT-nahen Systeme, angefangen im Konsumerbereich (z.B. digitale Kameras) bis hin zu unternehmenskritischen Applikationen führen im Hintergrund Metadaten - parallel zu den eigentlichen Hauptdaten. Metadaten im Allgemeinen sind per se als neutral, d.h. weder positiv noch negativ, zu bewerten. So wirken sich diese häufig positiv auf das Finden und Sortieren von digitalen Dokumenten aus. Negativ treten Metadaten eigentlich immer nur dann in Erscheinung, sobald diese ursprünglich zusätzlichen und nützlichen (und daher im Gegensatz zu den Hauptdaten nicht besonders beachteten bzw. geschützten) Informationen entgegen ihrer Bestimmung, zweckentfremdet werden. Auch Verzeichnisdienste verfügen über solche nützlichen Metadaten zu den jeweils in ihnen gespeicherten Inhalten. Ob, und wenn ja wie weit diese nützlichen Inhalte auch ein Risiko darstellen können wird im Rahmen dieses Artikels anhand eines konkreten Szenarios aus dem Umfeld des Systemmanagements gezeigt.

  7. Molekulare Methoden zum Nachweis, zur Quantifizierung und zum Monitoring der Mykotoxinbildung lebensmittelrelevanter Pilze

    NASA Astrophysics Data System (ADS)

    Geisen, Rolf

    Schimmelpilze kommen ubiquitär vor und spielen besonders bei pflanzlichen Lebensmitteln und Rohprodukten eine besondere Rolle als Verderbsorganismen. Es wird geschätzt, dass 20-25 % der jährlichen Produktion an pflanzlichen Produkten durch Schimmelpilze verdorben werden (Smith et al., 1994). Viele der lebensmittelrelevanten Schimmelpilze sind zudem in der Lage, Mykotoxine, toxische Sekundärmetabolite, zu bilden, was das Ausmaß des Problems deutlich macht. Die wichtigsten mykotoxinbildenden Spezies gehören zu den Fusarien (Trichothecene, Fumonisine, Zearalenon), Aspergillen (Aflatoxin, Ochratoxin, Cyclopiazonsäure) und Penicillien (Patulin, Ochratoxin). Für viele Mykotoxine, wie die Aflatoxine, Ochratoxin, Fumonisine und Trichothecene sind Grenzwerte erlassen worden, die die Verkehrsfähigkeit betroffener Produkte regeln. Die Einhaltung der Grenzwerte kann sehr genau durch offizielle chemisch-analytische Methoden, wie HPLC, GC-MS etc. kontrolliert werden. Diese analytischen Methoden sind aber für die Anwendung eines HACCP-Ansatzes zur Kontrolle der Mykotoxinbildung nur bedingt geeignet, da sie Endpunktkontrollen darstellen und nur das über eine längere Zeit gebildete Mykotoxin bestimmen. Sie sagen daher nichts über die biologischen Bedingungen zur Zeit der Bildung durch den Pilz aus.

  8. Are two retrograde 3.5 mm screws superior to one 7.3 mm screw for anterior pelvic ring fixation in bones with low bone mineral density?

    PubMed Central

    Zderic, I.; Grechenig, S.; Richards, R. G.; Schmitz, P.; Gueorguiev, B.

    2017-01-01

    Objectives Osteosynthesis of anterior pubic ramus fractures using one large-diameter screw can be challenging in terms of both surgical procedure and fixation stability. Small-fragment screws have the advantage of following the pelvic cortex and being more flexible. The aim of the present study was to biomechanically compare retrograde intramedullary fixation of the superior pubic ramus using either one large- or two small-diameter screws. Materials and Methods A total of 12 human cadaveric hemipelvises were analysed in a matched pair study design. Bone mineral density of the specimens was 68 mgHA/cm3 (standard deviation (sd) 52). The anterior pelvic ring fracture was fixed with either one 7.3 mm cannulated screw (Group 1) or two 3.5 mm pelvic cortex screws (Group 2). Progressively increasing cyclic axial loading was applied through the acetabulum. Relative movements in terms of interfragmentary displacement and gap angle at the fracture site were evaluated by means of optical movement tracking. The Wilcoxon signed-rank test was applied to identify significant differences between the groups Results Initial axial construct stiffness was not significantly different between the groups (p = 0.463). Interfragmentary displacement and gap angle at the fracture site were also not statistically significantly different between the groups throughout the evaluated cycles (p ⩾ 0.249). Similarly, cycles to failure were not statistically different between Group 1 (8438, sd 6968) and Group 2 (10 213, sd 10 334), p = 0.379. Failure mode in both groups was characterised by screw cutting through the cancellous bone. Conclusion From a biomechanical point of view, pubic ramus stabilisation with either one large or two small fragment screw osteosynthesis is comparable in osteoporotic bone. However, the two-screw fixation technique is less demanding as the smaller screws deflect at the cortical margins. Cite this article: Y. P. Acklin, I. Zderic, S. Grechenig, R. G. Richards, P

  9. Endoscopic mucosal resection of colorectal adenomas > 20 mm: Risk factors for recurrence

    PubMed Central

    Briedigkeit, Alexander; Sultanie, Omar; Sido, Bernd; Dumoulin, Franz Ludwig

    2016-01-01

    AIM: To evaluate risk factors for local recurrence after endoscopic mucosal resection of colorectal adenomas > 20 mm. METHODS: Retrospective data analysis of 216 endoscopic mucosal resections for colorectal adenomas > 20 mm in 179 patients (40.3% female; median age 68 years; range 35-91 years). All patients had at least 1 follow-up endoscopy with a minimum control interval of 2 mo (mean follow-up 6 mo/2.0-43.4 mo). Possible factors associated with local recurrence were analyzed by univariate and multivariate analysis. RESULTS: Median size of the lesions was 30 mm (20-70 mm), 69.0% were localized in the right-sided (cecum, ascending and transverse) colon. Most of the lesions (85.6%) showed a non-pedunculated morphology and the majority of resections was in piecemeal technique (78.7%). Histology showed carcinoma or high-grade intraepithelial neoplasia in 51/216 (23.6%) lesions including 4 low risk carcinomas (pT1a, L0, V0, R0 - G1/G2). Histologically proven recurrence was observed in 33/216 patients (15.3%). Patient age > 65 years, polyp size > 30 mm, non-pedunculated morphology, localization in the right-sided colon, piecemeal resection and tubular-villous histology were found as associated factors in univariate analysis. On multivariate analysis, only localization in the right-sided colon (HR = 6.842/95%CI: 1.540-30.394; P = 0.011), tubular-villous histology (HR = 3.713/95%CI: 1.617-8.528; P = 0.002) and polyp size > 30 mm (HR = 2.563/95%CI: 1.179-5.570; P = 0.017) were significantly associated risk factors for adenoma recurrence. CONCLUSION: Meticulous endoscopic follow-up is warranted after endoscopic mucosal resection of adenomas localized in the right-sided colon larger than > 30 mm, with tubular-villous histology. PMID:26981180

  10. Magnetomotive optical coherence elastography (MM-OCE) for thermal therapy dosimetry (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Huang, Pin-Chieh; Marjanovic, Marina; Spillman, Darold R.; Odintsov, Boris M.; Boppart, Stephen A.

    2016-03-01

    Biomechanical properties of tissues have been utilized for disease detection, diagnosis, and progression, however they have not been extensively utilized for therapy dosimetry. Magnetic hyperthermia aims to kill cells and ablate tumors using magnetic nanoparticles (MNPs) either injected in or targeted to tumors. Upon application of an appropriate AC magnetic field, MNPs can heat target tissue while sparing non-targeted healthy tissue. However, a sensitive monitoring technique for the dose of magnetic hyperthermia is needed to prevent over-treatment and collateral injury. During hyperthermia treatments, the viscoelastic properties of tissues are altered due to protein denaturation, coagulation, and tissue dehydration, making these properties candidates for dosimetry. Magnetomotive optical coherence elastography (MM-OCE) utilizes MNPs as internal force transducers to probe the biomechanical properties of tissues. Therefore, we aim to evaluate the hyperthermia dose based on the elastic changes revealed by MM-OCE. In this study, MNPs embedded in tissues were utilized for both hyperthermia and MM-OCE measurements. Tissue temperature and elastic modulus were obtained, where the elastic modulus was extracted from the resonance frequency detected by MM-OCE. Results showed a correlation between stiffness and temperature change following treatment. To investigate the thermal-dose-dependent changes, intervals of hyperthermia treatment were repeatedly performed on the same tissue sequentially, interspersed with MM-OCE. With increasing times of treatment, tissue stiffness increased, while temperature rise remained relatively constant. These results suggest that MM-OCE may potentially identify reversible and irreversible tissue changes during thermal therapy, supporting the use of MM-OCE for dosimetric control of hyperthermia in future applications.

  11. Sagitally focusing scanning monochromator produces 0.4-mm focus (abstract)

    NASA Astrophysics Data System (ADS)

    Rosenbaum, G.; Sullivan, M.; Fischetti, R.; Rock, L.

    1992-01-01

    A sagitally focusing stage has been constructed for the double-crystal scanning monochromator on beam line X9-A at the NSLS which can be exchanged with the normally used flat crystal stage. The bending device located at 12.0 m from the source is designed to accept a beam up to 200-mm wide. The monochromator with bending stage can be scanned over Bragg angles from 10° to 71° corresponding to photon energies from 11.4 to 2.1 keV with Si-111 crystals. In conjunction with the vertically focusing mirror a point focus of 0.38 mm×0.18 mm [horizontal×vertical, full width at half maximum (FWHM) each] has been achieved at a focal length of 3.8 m (center of a four-circle diffractometer). Focused at the back of the experimental hutch (focal length=5.4 m) the focal size was 0.55 mm×0.30 mm. The measured horizontal width of the focus equals the calculated size of the demagnified source and is independent of the horizontal convergence used. The horizontal focus produced by the crystal is very clean: the full width at 1% of maximum is 1.5 mm and at 0.01% it is about 4 mm. The flux into the focus is 5×1011 photons/s at a photon energy of 7.4 keV and beam current of 200 mA. The average flux density in the center of the focus (FWHM area) is 5×1011 photons/s/mm2. The preliminary crystal presently used has been made from a thin Si plate of 0.4-mm thickness, 80-mm width, and 75-mm length (in the direction of the beam). Steel ribs of 0.6-mm thickness have been glued at 3-mm pitch to the back of the crystal in order to stiffen the plate and reduce anticlastic bending.1 Plates have been glued to this crystal plate to extend the width to size the bending stage. The crystal was cut in 111 orientation with a 4° angle between the lattice planes and the crystal surface. The asymmetric cut was used to increase the angle of incidence and thus decrease the effect of the remaining anticlastic bending. The bending stage has a bending couple at both ends of the crystal in order to produce the

  12. Development and application of QM/MM methods to study the solvation effects and surfaces

    SciTech Connect

    Dibya, Pooja Arora

    2010-01-01

    Quantum mechanical (QM) calculations have the advantage of attaining high-level accuracy, however QM calculations become computationally inefficient as the size of the system grows. Solving complex molecular problems on large systems and ensembles by using quantum mechanics still poses a challenge in terms of the computational cost. Methods that are based on classical mechanics are an inexpensive alternative, but they lack accuracy. A good trade off between accuracy and efficiency is achieved by combining QM methods with molecular mechanics (MM) methods to use the robustness of the QM methods in terms of accuracy and the MM methods to minimize the computational cost. Two types of QM combined with MM (QM/MM) methods are the main focus of the present dissertation: the application and development of QM/MM methods for solvation studies and reactions on the Si(100) surface. The solvation studies were performed using a discreet solvation model that is largely based on first principles called the effective fragment potential method (EFP). The main idea of combining the EFP method with quantum mechanics is to accurately treat the solute-solvent and solvent-solvent interactions, such as electrostatic, polarization, dispersion and charge transfer, that are important in correctly calculating solvent effects on systems of interest. A second QM/MM method called SIMOMM (surface integrated molecular orbital molecular mechanics) is a hybrid QM/MM embedded cluster model that mimics the real surface.3 This method was employed to calculate the potential energy surfaces for reactions of atomic O on the Si(100) surface. The hybrid QM/MM method is a computationally inexpensive approach for studying reactions on larger surfaces in a reasonably accurate and efficient manner. This thesis is comprised of four chapters: Chapter 1 describes the general overview and motivation of the dissertation and gives a broad background of the computational methods that have been employed in this work

  13. Analysis of stable tearing in a 7.6 mm thick aluminum plate alloy

    SciTech Connect

    Dawicke, D.S.; Piascik, R.S.; Newman, J.C. Jr.

    1997-12-31

    The behavior of a 7.6 mm thick 2000 series aluminum plate alloy was investigated. Fracture tests were conducted on 304.8 mm and 101.6 mm wide M(T) specimens and 152.4 mm and 101.6 C(T) specimens. Two-dimensional and three-dimensional, elastic-plastic finite element simulations used the critical CTOA criterion to simulate the fracture behavior. A plane strain core was used in the two-dimensional analyses to approximate the three-dimensional constraint. The results from this study indicate: (A) The three-dimensional finite element analyses required a critical CTOA of 5.75{degree} to simulate the fracture behavior of the 101.6 mm and 304.8 mm wide M(T) specimen with side grooves. This angle was about the upper limit of the surface CTOA measurements. (B) The three-dimensional finite element analyses required a critical CTOA of 3.6{degree} to simulate the fracture behavior of the 101.6 mm C(T) specimen with side grooves. This angle was about the upper limit of the microtopography through-thickness CTOA measurements. (C) A plane strain core height of PSC = 4 mm was required for the two-dimensional analyses to match the fracture behavior obtained from the three-dimensional analyses. This height agreed with the distance that a three-dimensional analysis indicated was the start of plane strain like behavior. (D) For large M(T) specimens (W > 1,000 mm) the two-dimensional plane strain core analysis predicted a failure stress between the plane stress and plane strain conditions and provided a good approximation of the three-dimensional analyses. (E) The experimental measurements and analytical results show good agreement when the specimens sizes meet the uncracked ligament to thickness ratio (b/B > 4) determined by Newman et al. This indicates that there is a minimum size laboratory specimen that can be used to determine the material behavior needed to predict fracture in large specimens and structures.

  14. Use of 5-mm-diameter implants: Periotest values related to a clinical and radiographic evaluation.

    PubMed

    Aparicio, C; Orozco, P

    1998-12-01

    A modified design of the original Brånemark implant consisting of a cp. Titanium 5.0-mm-diameter self-tapping implant threaded up to the marginal platform has been proposed for specific indications. From February 1992 to November 1995, a total of 185 machined screw implants (Nobel Biocare, Gothenburg, Sweden) were installed in 45 patients to withstand 58 prostheses. Of these, 91 were 3.75-mm diameter and 94 were 5.0-mm wide. Most of the implants were placed in type B and C bone quantity and type 2 and 3 bone quality. A retrospective evaluation with regard to indications, marginal bone remodelling, Periotest values (PTv) and survival rate is presented. PTv and radiographic measurements were made at abutment connection and repeated 3, 6 and 12 months later and thereafter every year. The follow-up ranged from 16 to 55 months (mean 32.9 months) post-loading. Three patients with 8 5.0-mm implants dropped-out of the study at different stages. Out of the wide implants, 1 was expelled during the healing period; 3 were found mobile at the abutment connection; 1 lost its osseointegration suddenly after 2 years of function; 4 belonging to 1 patient did not meet the success criteria due to continuous marginal bone loss. The cumulative success rate of 5.0-mm implants (CSR) after 1 year of function was 97.2% for upper jaws and 88.4% in mandibles, whereas the CSR in maxilla after 48 months was 97.2% and 83.4% in mandibles. The obtained PTv from 5.0-mm-wide fixtures in maxilla and mandibles were respectively 1.1 and 0.6 units lower than those obtained PTv for 3.75-mm-diameter implants in the same patients. The hypothesis that there are differences in the damping capacity of the bone surrounding a 5.0-mm-wide implant compared to the 3.75-mm-diameter implant is supported by the PTv results.

  15. Fourier transform infrared absorption spectroscopy characterization of gaseous atmospheric pressure plasmas with 2 mm spatial resolution

    SciTech Connect

    Laroche, G.; Vallade, J.; Bazinette, R.; Hernandez, E.; Hernandez, G.; Massines, F.; Nijnatten, P. van

    2012-10-15

    This paper describes an optical setup built to record Fourier transform infrared (FTIR) absorption spectra in an atmospheric pressure plasma with a spatial resolution of 2 mm. The overall system consisted of three basic parts: (1) optical components located within the FTIR sample compartment, making it possible to define the size of the infrared beam (2 mm Multiplication-Sign 2 mm over a path length of 50 mm) imaged at the site of the plasma by (2) an optical interface positioned between the spectrometer and the plasma reactor. Once through the plasma region, (3) a retro-reflector module, located behind the plasma reactor, redirected the infrared beam coincident to the incident path up to a 45 Degree-Sign beamsplitter to reflect the beam toward a narrow-band mercury-cadmium-telluride detector. The antireflective plasma-coating experiments performed with ammonia and silane demonstrated that it was possible to quantify 42 and 2 ppm of these species in argon, respectively. In the case of ammonia, this was approximately three times less than this gas concentration typically used in plasma coating experiments while the silane limit of quantification was 35 times lower. Moreover, 70% of the incoming infrared radiation was focused within a 2 mm width at the site of the plasma, in reasonable agreement with the expected spatial resolution. The possibility of reaching this spatial resolution thus enabled us to measure the gaseous precursor consumption as a function of their residence time in the plasma.

  16. Dual-side backward coupler waveguide orthomode transducer for the 3 mm band

    NASA Astrophysics Data System (ADS)

    Navarrini, Alessandro; Nesti, Renzo

    2008-07-01

    We describe the design, construction, and characterization results of a waveguide Orthomode Transducer (OMT) for the 3 mm band (84-116 GHz.) The OMT is based on a symmetric backward coupling structure and has a square waveguide input port (2.54 mm × 2.54 mm) and two single-mode waveguide outputs: a standard WR10 rectangular waveguide (2.54 mm × 1.27 mm,) and an oval waveguide with full-radius corners. The reverse coupling structure is located in the common square waveguide arm and splits one polarization signal in two opposite rectangular waveguide sidearms using broadband -3 dB E-plane branch-line hybrid couplers. The device was optimized using a commercial 3D electromagnetic simulator. The OMT consists of two mechanical blocks fabricated in split-block configuration using conventional CNC milling machine. From 84 to 116 GHz the measured input reflection coefficient was less than -17 dB, the isolation between the outputs was less than -50 dB, the cross polarization was less than -30 dB, and the transmission was larger than -0.35 dB at room temperature for both polarization channels. The device is suitable for scaling to higher frequency.

  17. POLYVIEW-MM: web-based platform for animation and analysis of molecular simulations.

    PubMed

    Porollo, Aleksey; Meller, Jaroslaw

    2010-07-01

    Molecular simulations offer important mechanistic and functional clues in studies of proteins and other macromolecules. However, interpreting the results of such simulations increasingly requires tools that can combine information from multiple structural databases and other web resources, and provide highly integrated and versatile analysis tools. Here, we present a new web server that integrates high-quality animation of molecular motion (MM) with structural and functional analysis of macromolecules. The new tool, dubbed POLYVIEW-MM, enables animation of trajectories generated by molecular dynamics and related simulation techniques, as well as visualization of alternative conformers, e.g. obtained as a result of protein structure prediction methods or small molecule docking. To facilitate structural analysis, POLYVIEW-MM combines interactive view and analysis of conformational changes using Jmol and its tailored extensions, publication quality animation using PyMol, and customizable 2D summary plots that provide an overview of MM, e.g. in terms of changes in secondary structure states and relative solvent accessibility of individual residues in proteins. Furthermore, POLYVIEW-MM integrates visualization with various structural annotations, including automated mapping of known inter-action sites from structural homologs, mapping of cavities and ligand binding sites, transmembrane regions and protein domains. URL: http://polyview.cchmc.org/conform.html.

  18. Ultrasonic micro-motor using miniature piezoelectric tube with diameter of 1.0 mm.

    PubMed

    Zhang, Hui; Dong, Shu-xiang; Zhang, Shu-yi; Wang, Tian-hua; Zhang, Zhong-ning; Fan, Li

    2006-12-22

    At the present moment, the smallest piezoelectric ultrasonic micro-motors utilizing miniature PZT piezoelectric ceramic tubes were developed. The motor consists of a PZT-metal composite tube stator, two steel rotors and a thin shaft that keeps the two rotors pressing on both ends of the stator elastically. The dimensions of the PZT tube are 1.0 mm in outer diameter, 0.6 mm in inner diameter and 5.0 mm in length. The diameter and total length of the assembled micro-motor is 1.0 mm and 8 mm (including an adjusting spring), respectively. The tube-type micro-motor is driven by two pairs of alternative voltages with phase shift 90 degrees between the adjacent electrodes and operated in the first circular-bending vibration mode of the stator with the resonance frequency about 58 kHz. The experimental results show that the tube-type micro-motors have perfect performances: (i) high rotation frequency over 3000 rpm and (ii) large starting torque over 7.8 microN m under the conditions of the input voltage of 110 V(p-p) and the resonance frequency. The micro-motor is well suitable for operating in micro-spaces, such as in intravascular, micro-robots and micro-craft applications.

  19. Ultra-Compact Multitip Scanning Probe Microscope with an Outer Diameter of 50 mm

    NASA Astrophysics Data System (ADS)

    Cherepanov, Vasily; Zubkov, Evgeny; Junker, Hubertus; Korte, Stefan; Blab, Marcus; Coenen, Peter; Voigtländer, Bert

    We present a multitip scanning tunneling microscope (STM) where four independent STM units are integrated on a diameter of 50 mm. The coarse positioning of the tips is done under the control of an optical microscope or an SEM in vacuum. The heart of this STM is a new type of piezoelectric coarse approach called Koala Drive which can have a diameter greater than 2.5 mm and a length smaller than 10 mm. Alternating movements of springs move a central tube which holds the STM tip or AFM sensor. This new operating principle provides a smooth travel sequence and avoids shaking which is intrinsically present for nanopositioners based on inertial motion with saw tooth driving signals. Inserting the Koala Drive in a piezo tube for xyz-scanning integrates a complete STM inside a 4 mm outer diameter piezo tube of <10 mm length. The use of the Koala Drive makes the scanning probe microscopy design ultra-compact and accordingly leads to a high mechanical stability. The drive is UHV, low temperature, and magnetic field compatible. The compactness of the Koala Drive allows building a four-tip STM as small as a single-tip STM with a drift of <0.2 nm/min and lowest resonance frequencies of 2.5 (xy) and 5.5 kHz (z). We present examples of the performance of the multitip STM designed using the Koala Drive.

  20. Quantifying and monitoring convection intensity from mm-wave sounder observations

    NASA Astrophysics Data System (ADS)

    Haddad, Ziad S.; Sawaya, Randy S.; Kacimi, Sahra; Sy, Ousmane O.; Steward, Jeffrey L.

    2016-05-01

    Few systematic attempts to interpret the measurements of mm-wave radiometers over clouds and precipitation have been made to date because the scattering signatures of hydrometeors at these frequencies are very difficult to model. The few algorithms that have been developed try to retrieve surface precipitation, to which the observations are partially correlated but not directly sensitive. In fact, over deep clouds, mm-wave radiometers are most sensitive to the scattering from solid hydrometeors within the upper levels of the cloud. In addition, mm-wave radiometers have a definite advantage over the lower-frequency window-channel radiometers in that they have finer resolution and can therefore explicitly resolve deep convection. Preliminary analyses (in particular of NOAA's MHS brightness temperatures, as well as Megha-Tropiques's SAPHIR observations) indicate that the measurements are indeed very sensitive to the depth and intensity of convection. The challenge is to derive a robust approach to make quantitative estimates of the convection, for example the height and depth of the condensed water, directly from the mm-wave observations, as a function of horizontal location. To avoid having to rely on a specific set of microphysical assumptions, this analysis exploits the substantial amount of nearly- simultaneous coincident observations by mm-wave radiometers and orbiting atmospheric profiling radars in order to enforce unbiased consistency between the calculated brightness temperatures and the radar and radiometer observations.

  1. Fourier transform infrared absorption spectroscopy characterization of gaseous atmospheric pressure plasmas with 2 mm spatial resolution.

    PubMed

    Laroche, G; Vallade, J; Bazinette, R; van Nijnatten, P; Hernandez, E; Hernandez, G; Massines, F

    2012-10-01

    This paper describes an optical setup built to record Fourier transform infrared (FTIR) absorption spectra in an atmospheric pressure plasma with a spatial resolution of 2 mm. The overall system consisted of three basic parts: (1) optical components located within the FTIR sample compartment, making it possible to define the size of the infrared beam (2 mm × 2 mm over a path length of 50 mm) imaged at the site of the plasma by (2) an optical interface positioned between the spectrometer and the plasma reactor. Once through the plasma region, (3) a retro-reflector module, located behind the plasma reactor, redirected the infrared beam coincident to the incident path up to a 45° beamsplitter to reflect the beam toward a narrow-band mercury-cadmium-telluride detector. The antireflective plasma-coating experiments performed with ammonia and silane demonstrated that it was possible to quantify 42 and 2 ppm of these species in argon, respectively. In the case of ammonia, this was approximately three times less than this gas concentration typically used in plasma coating experiments while the silane limit of quantification was 35 times lower. Moreover, 70% of the incoming infrared radiation was focused within a 2 mm width at the site of the plasma, in reasonable agreement with the expected spatial resolution. The possibility of reaching this spatial resolution thus enabled us to measure the gaseous precursor consumption as a function of their residence time in the plasma.

  2. Survival and growth of age-0 steelhead after surgical implantation of 23-mm passive integrated transponders

    USGS Publications Warehouse

    Bateman, D.S.; Gresswell, R.E.

    2006-01-01

    Little information is available on the effects of implanting 23-mm passive integrated transponder (PIT) tags in salmonids less than 90 mm fork length (FL). Using juvenile steelhead Oncorhynchus mykiss (range, 73–97 mm FL), we compared instantaneous growth rates and survival among three experimental groups: control, surgery with no tag, and surgery with tag. Survival rate was lower for tagged fish (86%) than for control and surgery−no tag fish (virtually 100% in each group). Approximately 90% of the mortalities occurred during days 1–3. Growth rate for the tagged group was lower for the first two 10-d measurement intervals; however, during the third 10-d interval, growth rates for tagged fish equaled or exceeded values for the other groups. These results suggest that tagged fish recovered by day 20. Growth rates for the control and surgery−no tag groups did not differ from one another during any measurement interval. Tag retention rate was 97% over the 30-d period of the study. It appears that the combination of fish length and tag size in this study resulted in short-term negative effects on growth rate and survival; however, 23-mm PIT tags may still be useful for studies of salmonids 80–90 mm FL when survival is not the parameter of interest.

  3. Planeten beobachten. Praktische Anleitung für Amateurbeobachter und solche, die es werden wollen.

    NASA Astrophysics Data System (ADS)

    Roth, G. D.

    Contents: 1. Amateurastronomie und Planetenbeobachtung (H.-J. Mettig, G. D. Roth). 2. Die visuelle Beobachtung (G. D. Roth). 3. Mond- und Planetenphotographie (B. Koch). 4. Die CCD-Bildbearbeitung (R. A. Hillebrecht). 5. Tabellen zur Ermittlung der Belichtungszeiten für Mond- und Planetenaufnahmen (W. Gruschel). 6. Die lichtelektrische Beobachtung (G. D. Roth). 7. Die Objekte in Einzeldarstellungen: Merkur (D. Niechoy); Venus (D. Niechoy); Erdmond (G. D. Roth); Mars (C. M. Schambeck); Kleine Planeten (M. Hoffmann, G. D. Roth, J. Meeus); Jupiter (H.-J. Mettig, R. C. Stoyan, A. Nikolai, C. Kowalec, G. Hahn); Saturn (R. C. Stoyan, G. Hahn, H.-J. Mettig); Uranus (R. C. Stoyan); Neptun (R. C. Stoyan); Pluto (R. C. Stoyan). 8. Adressen, Literaturhinweise, Register.

  4. Rehabilitation of the atrophic posterior mandible with short (4-mm) implants: a case report.

    PubMed

    Pistilli, Roberto; Barausse, Carlo; Checchi, Luigi; Felice, Pierto

    2014-01-01

    This case report describes a successful implant-prosthetic rehabilitation of an atrophic posterior mandible with 4-mm-long implants. The patient refused to undergo any reconstructive surgery, and because the available bone up to the inferior alveolar nerve was only 5 mm or less, the patient received four implants of 4-mm length. Four months after implant placement, a provisional prosthesis was put in place; after another 4 months, this was then in turn replaced with a definitive prosthesis. The use of such short implants allows a fixed prosthetic solution without the need for vertically augmenting the mandibular bone. This procedure considerably reduces intra- and postoperative patient discomfort compared with reconstructive surgery for the placement of longer implants. The follow-up time was 1 year after implant loading.

  5. Evidence for Highly Inhomogeneous mm-Wave Sources During the Impulsive Flare of May 9, 1991

    NASA Technical Reports Server (NTRS)

    Hermann, R.; Magun, A.; Kaufmann, P.; Correia, E.; Costa, J. E. R.; Machado, M. E.; Fishman, G.

    1997-01-01

    In this paper multiwavelength observations of an impulsive flare of May 9, 1991 are presented. This event was observed with the 48 GHz multibeam focal array used at the Itapetinga radio telescope, the microwave patrol telescopes at Bem and the BATSE high time resolution hard X-ray spectrometer on board CGRO. While spatially unresolved low sensitivity observations show two major impulsive peaks, the mm-wave observations with the ability of spatially high resolved tracking of the emission centroids suggest a primarily bipolar source configuration. For the first time two mm-wave sources with a spacing below the HPBW could be separated with the multibeam technique. The general features of the observations are explained as emission of partially trapped electrons. Furthermore we present evidence for highly inhomogeneous substructures within one of the two mm-wave sources for which the positional scatter of the emission center, within 2s, is less than 2".

  6. Improvement of rolling 6 mm thin plates in plate rolling mill PT. Krakatau Posco

    NASA Astrophysics Data System (ADS)

    Pujiyanto, Hamdani

    2017-01-01

    A 6-mm thin plate is difficult to produce especially if the product requires wide size and high strength. Flatness is the main quality issue in rolling 6-mm plate using a 4-high reversing mill which use ±1100-mm work roll. Thus some methods are applied to overcome such issue in order to comply to customer quality requirement. Pre-rolling, rolling, and post-rolling conditions have to be considered comprehensively. Roll unit management will be the key factor before rolling condition. The roll unit itself has a significant impact on work roll crown wearness in relation with work roll intial crown and thermal crown. Work roll crown along with the modification of hydraulic gap control (HGC) could directly alter the flatness of the plate.

  7. A 12-mm carcinoid tumor of the minor duodenal papilla with lymph node metastases.

    PubMed

    Fukami, Yasuyuki; Kurumiya, Yasuhiro; Mizuno, Keisuke; Sekoguchi, Ei; Kobayashi, Satoshi; Ito, Akira; Tomida, Akihiro; Onishi, Sakura; Shirotsuki, Ryo; Okubo, Kenji; Narita, Michihiko

    2013-01-01

    Carcinoid tumors located in the minor duodenal papilla are extremely rare, with only a few cases reported in the literature. Herein, we report the case of a 71-year-old man with a 12-mm carcinoid tumor at the minor duodenal papilla with lymph node metastases. Multidetector-row computed tomography with contrast enhancement revealed a 12-mm well-enhanced tumor in the duodenum. Upper gastrointestinal endoscopy showed a 12-mm submucosal tumor at the minor papilla of the duodenum. Biopsy specimens revealed a carcinoid tumor, and a subtotal stomach-preserving pancreatoduodenectomy was performed. Carcinoid tumors at the minor duodenal papilla have a high prevalence of nodal disease, even for tumors <2 cm in diameter. Therefore, we believe that radical resection with tumor-free margins (i.e. pancreatoduodenectomy) is the treatment of choice.

  8. Three-degree-of-freedom ultrasonic motor using a 5-mm-diameter piezoelectric ceramic tube.

    PubMed

    Mingsen Guo; Junhui Hu; Hua Zhu; Chunsheng Zhao; Shuxiang Dong

    2013-07-01

    A small three-degree-of-freedom ultrasonic motor has been developed using a simple piezoelectric lead zirconate titanate (PZT)-tube stator (OD 5 mm, ID 3 mm, length 15 mm). The stator drives a ball-rotor into rotational motion around one of three orthogonal (x-, y-, and z-) axes by combing the first longitudinal and second bending vibration modes. A motor prototype was fabricated and characterized; its performance was superior to those of previous motors made with a PZT ceramic/metal composite stator of comparable size. The method for further improving the performance was discussed. The motor can be further miniaturized and it has potential to be applied to medical microrobots, endoscopes or micro laparoscopic devices, and cell manipulation devices.

  9. Ultrastructural response of rat lung to 90 days' exposure to oxygen at 450 mm Hg

    NASA Technical Reports Server (NTRS)

    Harrison, G. A.

    1974-01-01

    Young Sprague-Dawley rats were exposed to 100% oxygen at 450 mm Hg in constant environment capsules for 90 days. Lung tissue examined by electron microscopy revealed a number of changes, many similar to those observed after exposure to oxygen at 760 mm Hg for shorter periods of time. Alterations in vesicle size and number and in mitochondrial matrix and cristae appear in both the endothelial and epithelial cells. Blebbing and rarefication of cytoplasm occur in both cell layers of the alveolo-capillary wall. Also seen are fluid in the basement membrane, platelets in the capillaries, and alveolar fluid and debris. All of these alterations occur at 1 atm exposure. However, after exposure to 450 mm Hg the changes are not as widespread nor as destructive as they are at the higher pressure.

  10. GTKDynamo: a PyMOL plug-in for QC/MM hybrid potential simulations

    PubMed Central

    Bachega, José Fernando R.; Timmers, Luís Fernando S.M.; Assirati, Lucas; Bachega, Leonardo R.; Field, Martin J.; Wymore, Troy

    2014-01-01

    Hybrid quantum chemical (QC)/molecular mechanical (MM) potentials are very powerful tools for molecular simulation. They are especially useful for studying processes in condensed phase systems, such as chemical reactions, that involve a relatively localized change in electronic structure and where the surrounding environment contributes to these changes but can be represented with more computationally efficient functional forms. Despite their utility, however, these potentials are not always straightforward to apply since the extent of significant electronic structure changes occurring in the condensed phase process may not be intuitively obvious. To facilitate their use we have developed an open-source graphical plug-in, GTKDynamo, that links the PyMOL visualization program and the pDynamo QC/MM simulation library. This article describes the implementation of GTKDynamo and its capabilities and illustrates its application to QC/MM simulations. PMID:24137667

  11. Recording and wear characteristics of 4 and 8 mm helical scan tapes

    NASA Technical Reports Server (NTRS)

    Peter, Klaus J.; Speliotis, Dennis E.

    1993-01-01

    Performance data of media on helical scan tape systems (4 and 8 mm) is presented and various types of media are compared. All measurements were performed on a standard MediaLogic model ML4500 Tape Evaluator System with a Flash Converter option for time based measurements. The 8 mm tapes are tested on an Exabyte 8200 drive and 4 mm tapes on an Archive Python drive; in both cases, the head transformer is directly connected to a Media Logic Read/Write circuit and test electronics. The drive functions only as a tape transport and its data recover circuits are not used. Signal to Noise, PW 50, Peak Shift and Wear Test data is used to compare the performance of MP (metal particle), BaFe, and metal evaporate (ME). ME tape is the clear winner in magnetic performance but its susceptibility to wear and corrosion, make it less than ideal for data storage.

  12. Performance of a mmWave beamformed phased array system for indoor LOS communication

    NASA Astrophysics Data System (ADS)

    Amjad, Kinnan; Xu, Huaping

    2016-11-01

    Millimeter waves (mmWaves) spectrum ranging from 30GHz to 300GHz is emerging as a potential solution to the bandwidth problem faced by the wireless communication now a days. The advancements in the antenna technology has enabled the fabrication of antenna arrays or phased array systems which when used with techniques like spatial multiplexing and beamforming has enabled the use of mmWaves for both indoor and outdoor communication systems by providing gain and selectivity. This has also opened the doors for its potential use in long range and cellular communications. The 60GHz band also know as the oxygen absorption band due to its higher attenuation and unlicensed operation is a good candidate for use in secure and confined communications. In this paper we have investigated the performance of a beamformed phased array system in the mmWave spectrum. The performance is measured for varying the source and noise location and compared for a Linear and Rectangular array.

  13. Efficient approach to obtain free energy gradient using QM/MM MD simulation

    SciTech Connect

    Asada, Toshio; Koseki, Shiro; Ando, Kanta

    2015-12-31

    The efficient computational approach denoted as charge and atom dipole response kernel (CDRK) model to consider polarization effects of the quantum mechanical (QM) region is described using the charge response and the atom dipole response kernels for free energy gradient (FEG) calculations in the quantum mechanical/molecular mechanical (QM/MM) method. CDRK model can reasonably reproduce energies and also energy gradients of QM and MM atoms obtained by expensive QM/MM calculations in a drastically reduced computational time. This model is applied on the acylation reaction in hydrated trypsin-BPTI complex to optimize the reaction path on the free energy surface by means of FEG and the nudged elastic band (NEB) method.

  14. A study on friction stir welding of 12mm thick aluminum alloy plates

    NASA Astrophysics Data System (ADS)

    Kumar, Deepati Anil; Biswas, Pankaj; Tikader, Sujoy; Mahapatra, M. M.; Mandal, N. R.

    2013-12-01

    Most of the investigations regarding friction stir welding (FSW) of aluminum alloy plates have been limited to about 5 to 6 mm thick plates. In prior work conducted the various aspects concerning the process parameters and the FSW tool geometry were studied utilizing friction stir welding of 12 mm thick commercial grade aluminum alloy. Two different simple-to-manufacture tool geometries were used. The effect of varying welding parameters and dwell time of FSW tool on mechanical properties and weld quality was examined. It was observed that in order to achieve a defect free welding on such thick aluminum alloy plates, tool having trapezoidal pin geometry was suitable. Adequate tensile strength and ductility can be achieved utilizing a combination of high tool rotational speed of about 2000 r/min and low speed of welding around 28 mm/min. At very low and high dwell time the ductility of welded joints are reduced significantly.

  15. Aortic valve replacement with concomitant annular enlargement for small aortic annulus of less than 19 mm.

    PubMed

    Takakura, H; Sasaki, T; Hashimoto, K; Hachiya, T; Onoguchi, K; Oshiumi, M; Takeuchi, S

    2000-06-01

    Three female patients with aortic stenosis associated with a severely small annulus underwent aortic valve replacement. In intraoperative measurements, a 19-mm obtulator could not pass through the aortic annulus in each case. We therefore concluded that it would be difficult to implant an appropriate-sized prosthesis in a routine fashion, so we performed an annular enlargement in a modified Nicks procedure. By using a wide teardrop-shaped patch for enlargement and slightly tilting insertion of a prosthesis, a 21 mm bileaflet mechanical prosthesis could be inserted into the enlarged annulus. Despite being a simpler method than other enlarging procedures, a two- or three-sizes larger prosthesis than the native annulus can be inserted with relative ease. Thus, the use of a 19 mm mechanical prosthesis may be avoidable in most adult cases.

  16. Ground-based mm-wave emission spectroscopy for the detection and monitoring of stratospheric ozone

    NASA Technical Reports Server (NTRS)

    Parrish, A.; Dezafra, R.; Solomon, P.

    1981-01-01

    The molecular rotational spectrum of ozone is quite rich in the mm-wave region from 50 to 300 GHz. An apparatus, which was developed primarily for detection and measurement of stratospheric ClO and other trace molecules, is found to be well suited also for the observation of ozone lines. The collecting antenna of the apparatus is a simple mm-waveguide feedhorn. The detector is a superheterodyne mixer using a special high frequency Schottky diode and a klystron local oscillator. The spectrometer is a 256 channel filter bank with 1 MHz resolution per channel. The apparatus is believed to be the first ground-based mm-wave instrument having the capability of obtaining data of sufficient quality to make use of the inversion technique. The ground based radio technique is most sensitive to changes in vertical distribution in the region above 25 km, a region which is difficult to sample by other techniques.

  17. New Measurements of the Cosmic Background Radiation Temperature at3.3 mm Wavelength

    SciTech Connect

    Witebsky, C.; Smoot, G.; De Amici, G.; Friedman, S.D.

    1986-02-01

    We have measured the temperature of the cosmic background radiation (CBR) at 3.3 mm wavelength in 1982, 1983, and 1984 as part of a larger project to determine the CBR temperature at five wavelengths from 12 cm to 3.3 mm (Smoot et al. 1985). The 3.3-mm measurements yield a brightness temperature of 2.57 K with a 1{sigma} uncertainty of 20.12 K. This paper describes the instrument, the measurement techniques, and the data-analysis procedures used. Our result is in good agreement with recent measurements at comparable wavelengths by Meyer and Jura (1985) and by Peterson, Richards, and Timusk (1985), but it disagrees with the temperatures reported by Woody and Richards (1981).

  18. Technische Systeme für den Herzersatz und die Herzunterstützung

    NASA Astrophysics Data System (ADS)

    Schöb, Reto; Loree, Howard M.

    Herzkrankheiten verursachen allein in den Vereinigten Staaten jährlich mehr als 700’000 Todesfälle. Ungefähr 3 Millionen Patienten in den U.S.A. leiden gemäss der American Heart Association (AHA) und dem National Heart, Lung and Blood Institute (NHLBI) an kongestivem Herzversagen (Congestive Heart Failure, CHF), welches eine chronische, sehr entkräftende und degenerative Krankheit ist: Das Herz ist dabei unfähig, hinreichend Blut zu den Organen des Körpers zu pumpen. Über 400’000 Fälle von CHF werden jedes Jahr diagnostiziert. Ähnliche Zahlen werden für Europa und Japan zusammen geschätzt. Basierend auf Daten vom AHA und NHLBI beträgt die fünfjährige Überlebensrate für CHF-Patienten lediglich etwa 50% [1]. 70’000-120’000 dieser Patienten könnten von einer Herzverpflanzung profitieren. 1999 wurden in den USA aber nur 2185 Herztransplantationen durchgeführt während die Warteliste über 4000 Patienten beträgt [2]. Ein akuter Mangel an Spenderherzen und die enormen Kosten (250’000-400’000 USD pro Patient) sind die begrenzenden Faktoren für Herztransplantationen [3]. Dies bedeutet, dass eine riesige Anzahl von Patienten durch ein zuverlässiges und verschleissfreies, nichtthrombotisches, total implantierbares, künstliches Herz gerettet werden könnten. Bis heute jedoch kein derartiges Implantat kommerziell verfügbar.

  19. Third-body abrasive wear challenge of 32 mm conventional and 44 mm highly crosslinked polyethylene liners in a hip simulator model.

    PubMed

    Sorimachi, T; Clarke, I C; Williams, P A; Gustafson, A; Yamamoto, K

    2009-07-01

    Hip simulator studies have shown that wear in the polyethylene liners used for total hip replacements increased with the larger-diameter femoral balls and could also be exacerbated by third-body abrasion. However, they also indicated that the more highly cross-linked polyethylene (HXPE) bearings were more wear resistant than conventional polyethylene (CXPE) bearings. Unfortunately the HXPE bearings appeared to be particularly sensitive to adverse wear conditions. One simulator study in particular indicated that poly(methyl methacrylate) (PMMA) debris increased wear sixfold by means of two-body abrasive interactions rather than the supposed third-body abrasion or roughening effects of the Co-Cr surfaces. There has been no confirmation of such novel theories. Therefore the goal of this study was to investigate the sensitivity of large-diameter HXPE bearings to the third-body PMMA wear challenge in a hip simulator model. An orbital hip simulator was used in standard test mode with a physiological load profile. The 32 mm control liners were machined from moulded GUR1050 and gamma irradiated to 35 kGy under nitrogen (CXPE). The 44 mm liners were also from moulded blanks, gamma irradiated to 75 kGy, machined to shape, given a proprietary heat treatment, and sterilized by gas plasma (HXPE). As in the published simulator model, the study was conducted in three phases. In phase 1, all cups were run in standard ('clean') lubricant for 1.5 x 10(6) cycles duration. In phase 2, three CXPE cups and six HXPE cups were run for 2 x 10(6) cycles with a slurry of PMMA particles added to the lubricant. In phase 3, the implants were again run in 'clean' lubricant for 2 x 10(6) cycles duration. In addition, three HXPE cups were run as wear controls for 5.5 x 10(6) cycles duration in clean lubricant. In phase-1, the HXPE liners demonstrated twelvefold reduced wear compared with the CXPE controls. The 32 mm and 44 mm Co-Cr balls were judged of comparable roughnesses. However, the surface

  20. The Galactic Centre Mini-Spiral in the MM-Regime

    NASA Technical Reports Server (NTRS)

    Kunneriath, D.; Eckart, A.; Vogel, S. N.; Teuben, P.; Muzic, I.; Schoedel, R.; Garcia-Marin, M.; Moultaka, J.; Staguhn, J.; Straubmeier, C.; Zensus, J. A.; Valencia-S., M.; Karas, V.

    2012-01-01

    Context: The mini-spiral is a feature of the interstellar medium in the central approx.2 pc of the Galactic center. It is composed of several streamers of dust and ionised and atomic gas with temperatures between a few 100 K to 10(exp 4) K. There is evidence that these streamers are related to the so-called circumnuclear disk of molecular gas and are ionized by photons from massive, hot stars in the central parsec. Aims: We attempt to constrain the emission mechanisms and physical properties of the ionized gas and dust of the mini-spiral region with the help of our multiwavelength data sets. Methods: Our observations were carried out at 1.3 mm and 3 mm with the mm interferometric array CARMA in California in March and April 2009, with the MIR instrument VISIR at ESO's VLT in June 2006, and the NIR Bry with VLT NACO in August 2009. Results: We present high resolution maps of the mini-spiral, and obtain a spectral index of 0.5 +/- 0.25 for Sgr A *, indicating an inverted synchrotron spectrum. We find electron densities within the range 0.8-1.5 x 10(exp 4)/cu cm for the mini-spiral from the radio continuum maps, along with a dust mass contribution of approx. 0.25 Mo from the MIR dust continuum. and extinctions ranging from 1.8-3 at 2.16 microns in the Bry line. Conclusions: We observe a mixture of negative and positive spectral indices in our 1.3 mm and 3 mm observations of the extended emission of the mini-spiral, which we interpret as evidence that there are a range of contributions to the thermal free-free emission by the ionized gas emission and by dust at 1.3 mm.

  1. Anisodamine accelerates spontaneous passage of single symptomatic bile duct stones ≤ 10 mm

    PubMed Central

    Gao, Jun; Ding, Xue-Mei; Ke, Shan; Zhou, Yi-Ming; Qian, Xiao-Jun; Ma, Rui-Liang; Ning, Chun-Min; Xin, Zong-Hai; Sun, Wen-Bing

    2013-01-01

    AIM: To investigate the rate of spontaneous passage of single and symptomatic common bile duct (CBD) stones ≤ 10 mm in diameter in 4 wk with or without a 2-wk course of anisodamine. METHODS: A multicenter, randomized, placebo-controlled trial was undertaken. A total of 197 patients who met the inclusion criteria were enrolled. Ninety-seven patients were assigned randomly to the control group and the other 100 to the anisodamine group. The anisodamine group received intravenous infusions of anisodamine (10 mg every 8 h) for 2 wk. The control group received the same volume of 0.9% isotonic saline for 2 wk. Patients underwent imaging studies and liver-function tests every week for 4 wk. The rate of spontaneous passage of CBD stones was analyzed. RESULTS: The rate of spontaneous passage of CBD stones was significantly higher in the anisodamine group than that in the control group (47.0% vs 22.7%). Most (87.2%, 41/47) stone passages in the anisodamine group occurred in the first 2 wk, and passages in the control group occurred at a comparable rate each week. Factors significantly increasing the possibility of spontaneous passage by univariate logistic regression analyses were stone diameter (< 5 mm vs ≥ 5 mm and ≤ 10 mm) and anisodamine therapy. Multivariate logistic regression analyses revealed that these two factors were significantly associated with spontaneous passage. CONCLUSION: Two weeks of anisodamine administration can safely accelerate spontaneous passage of single and symptomatic CBD stones ≤ 10 mm in diameter, especially for stones < 5 mm. PMID:24151390

  2. Improving Student Understanding of Magmatic Differentiation Using an M&M Magma Chamber

    NASA Astrophysics Data System (ADS)

    Wirth, K. R.

    2003-12-01

    Many students, especially those in introductory geology courses, have difficulty developing a deep understanding of the processes of magmatic differentiation. In particular, students often struggle to understand Bowen's reaction series and fractional crystallization. The process of fractional crystallization by gravity settling can be illustrated using a model magma chamber consisting of M&M's. In this model, each major cation (e.g., Si, Ti, Al, Fe, Mg, Ca, Na, K) is represented by a different color M&M; other kinds of differently colored or shaped pieces could also be used. Appropriate numbers of each color M&M are combined to approximate the cation proportions of a basaltic magma. Students then fractionate the magma by moving M&M's to the bottom of the magma chamber forming a series of cumulus layers; the M&M's are removed in the stoichiometric proportions of cations in the crystallizing minerals (e.g., olivine, pyroxene, feldspars, quartz, magnetite, ilmenite). Students observe the changing cation composition (proportions of colors of M&M's) in the cumulus layers and in the magma chamber and graph the results using spreadsheet software. More advanced students (e.g., petrology course) can classify the cumulates and resulting liquid after each crystallization step, and they can compare the model system with natural magmatic systems (e.g., absence of important fractionating phases, volatiles). Students who have completed this exercise generally indicate a positive experience and demonstrate increased understanding of Bowen's reaction series and fractionation processes. They also exhibit greater familiarity with mineral stoichiometry, classification, solid-solution in minerals, element behavior (e.g., incompatibility), and chemical variation diagrams. Other models (e.g., paths of equilibrium and fractional crystallization on phase diagrams) can also be used to illustrate differentiation processes in upper level courses (e.g., mineralogy and petrology).

  3. A new 3 mm band receiver for the Onsala 20 m antenna

    NASA Astrophysics Data System (ADS)

    Belitsky, V.; Lapkin, I.; Fredrixon, M.; Sundin, E.; Helldner, L.; Pettersson, L.; Ferm, S.-E.; Pantaleev, M.; Billade, B.; Bergman, P.; Olofsson, A. O. H.; Lerner, M. S.; Strandberg, M.; Whale, M.; Pavolotsky, A.; Flygare, J.; Olofsson, H.; Conway, J.

    2015-08-01

    A new receiver for the Onsala 20 m antenna with the possibility of being equipped with 3 mm and 4 mm bands has been built and the 3 mm channel has been commissioned during the Spring 2014. For single-dish operation, the receiver uses an innovative on-source/off-source optical switch. In combination with additional optical components and within the same optical layout, the switch provides two calibration loads (for the 3 mm and 4 mm channels), sideband rejection measurement, and tuning possibilities. The optical layout of the receiver employs all cold (4 K) offset elliptical mirrors for both channels, whereas the on-off switch employs flat mirrors only. The 3 mm channel employs a sideband separation (2SB) dual polarization receiver with orthomode transducer (OMT), 4-8 GHz intermediate frequency (IF), x 2pol x upper and lower sidebands (USB + LSB). The cryostat has four optical windows made of high density polyethylene (HDPE) with anti-reflection corrugations, two for the signal and two for each frequency band cold load. The cryostat uses a two-stage cryocooler produced by Sumitomo HI RDK 408D2 with anti-vibration suspension of the cold-head to minimize impact of the vibrations on the receiver stability. The local oscillator (LO) system is based on a Gunn oscillator with aphase lock loop (PLL) and four mechanical tuners for broadband operation, providing independently tunable LO power for each polarization. This paper provides a technical description of the receiver and its technology and could be useful for instrumentation engineers and observers using the Onsala 20 m telescope.

  4. Binding free energy calculation with QM/MM hybrid methods for Abl-Kinase inhibitor.

    PubMed

    Dubey, Kshatresh Dutta; Ojha, Rajendra Prasad

    2011-01-01

    We report a Quantum mechanics/Molecular Mechanics-Poisson-Boltzmann/ Surface Area (QM/MM-PB/SA) method to calculate the binding free energy of c-Abl human tyrosine kinase by combining the QM and MM principles where the ligand is treated quantum mechanically and the rest of the receptor by classical molecular mechanics. To study the role of entropy and the flexibility of the protein ligand complex in a solvated environment, molecular dynamics calculations are performed using a hybrid QM/MM approach. This work shows that the results of the QM/MM approach are strongly correlated with the binding affinity. The QM/MM interaction energy in our reported study confirms the importance of electronic and polarization contributions, which are often neglected in classical MM-PB/SA calculations. Moreover, a comparison of semi-empirical methods like DFTB-SCC, PM3, MNDO, MNDO-PDDG, and PDDG-PM3 is also performed. The results of the study show that the implementation of a DFTB-SCC semi-empirical Hamiltonian that is derived from DFT gives better results than other methods. We have performed such studies using the AMBER molecular dynamic package for the first time. The calculated binding free energy is also in agreement with the experimentally determined binding affinity for c-Abl tyrosine kinase complex with Imatinib.Electronic supplementary material The online version of this article (doi:10.1007/s10867-010-9199-z) contains supplementary material, which is available to authorized users.

  5. Distribution of the solar radio brightness temperature at 8.6 mm wavelength.

    NASA Astrophysics Data System (ADS)

    Zhou, Ai H.; Wu, Hongao A.; Zhou, Sh. R.; Liu, Yan; Xiao, Hanliu

    1994-06-01

    The radial distribution of the solar radio brightness temperature at 8.6 mm wavelength is calculated, based on the total eclipse observation on Feb. 16, 1980. The results obtained by the first, second and third contacts show that there is an evident brightening structure with a single spike in the 2' range on the inner side of the optical limb. The average brightening value is about 18% of the central brightness temperature. Radiation from the brightening region is about 4% of total radiation from the solar disk. The average brightness temperature is 9727K at 8.6 mm wavelength on Feb. 16, 1980.

  6. Additional atmospheric opacity measurements at lambda = 1.1 mm from Mauna Kea Observatory, Hawaii

    NASA Technical Reports Server (NTRS)

    Parrish, A.; De Zafra, R. L.; Barrett, J. W.; Solomon, P.; Connor, B.

    1987-01-01

    Atmospheric opacity values in the zenith direction are given for a wavelength of 1.1 mm (278 GHz) at the summit of Mauna Kea in the Hawaiian Islands. A total of 75 days is covered during the period 1983-1986. Observations were made on a quasi-continuous basis, with opacity measured every 20 minutes around the clock for significant periods of time. A conversion from opacity at lambda = 1.1 mm to the equivalent precipitable water vapor column is given from the measurements of Zammit and Ade (1981), from which opacities at other wavelengths may be derived.

  7. Dynamische Satzgenerierung und Sprachausgabe für einen mobilen Serviceroboter

    NASA Astrophysics Data System (ADS)

    Parlitz, Christopher; Amann, Bernd; Hägele, Martin

    Die vorliegende Arbeit befasst sich mit der Entwicklung einer Sprachausgabe für ein mobiles Robotersystem. Dazu wurde zum einen ein auf die Anwendung zugeschittenes Text-To-Speech Verfahren und zum anderen eine Grammatik, die eine dynamische Satzgenerierung ermöglicht, implementiert. Die Verfahren arbeiten unabhängig voneinander und können daher auch gegen andere Komponenten ausgetauscht werden. Die Programme wurden als Client-Server Applikationen programmiert, um möglichst flexibel die Sprachausgabe einsetzen zu können.

  8. Biologie statt Philosophie? Evolutionäre Kulturerklärungen und ihre Grenzen

    NASA Astrophysics Data System (ADS)

    Illies, Christian

    Vor über siebzig Jahren fand man in einer Höhle nahe Hohlenstein-Stadel, im heutigen Baden-Württemberg, eine Frau, die keiner bekannten Spezies und nicht einmal eindeutig den Hominiden zugeordnet werden konnte. Wegen ihres Aussehens wurde sie schon bald als "Löwenfrau“ bekannt (unterdessen wird sie als "Löwenmensch“ bezeichnet, da die in solchen Fragen Klarheit schaffenden Geschlechtsteile bei der Figur fehlen und in Zeiten von gender mainstreaming derartige Festlegungen gerne vermieden werden), denn sie hatte eine menschlich-aufrechte, unbehaarte Gestalt mit weiblichen Rundungen, aber zugleich eine Mähne, sowie Augen, Ohren und Schnauze eines Löwen. Eine sehr weitläufige Verwandte des Minotaurus, so schien es, und doch wesentlich älter als alle Bewohner des Olymps, denn vermutlich wurde die knapp 30 cm große Skulptur bereits in der Altsteinzeit vor etwa 32.000 Jahren aus Mammut-Elfenbein geschnitzt. Wir wissen nicht, ob sie kultischen Zwecken diente oder ein Kind mit ihr spielte, ob sie als Glücksbringer für die Jagd oder als Schamanin mit Löwenmaske verehrt und gefürchtet wurde. Aber die Löwenfrau legt nahe, dass der Mensch schon im Morgendämmern seiner Kultur über die eigene Nähe, aber auch Distanz zum Tier nachgedacht haben muss. Die Frage nach der menschlichen Selbstverortung begegnet uns in dieser Figur, und sie bestimmt viele Zeugnisse menschlichen Nachdenkens, welche uns die Altertumswissenschaften vorlegen. Mit dem Begriff "animal rationale“, wie er unter Bezug auf Aristoteles geprägt wurde, findet sie schließlich ihre klassische, für das Abendland lange Zeit maßgebliche Antwort: Der Mensch als Tier, dessen spezifisches Merkmal die Vernunftbegabtheit ist, die ihn zugleich von allen anderen Tieren abgrenzt und über sie stellt. Aber wo genau verläuft die Grenze? Und wie kann der Mensch beides zugleich sein? Die aristotelische Definition beantwortet diese Fragen nach der Doppelnatur nicht, sondern erhebt das offene R

  9. Vom Referat bis zur Examensarbeit: Naturwissenschaftliche Texte perfekt verfassen und gestalten

    NASA Astrophysics Data System (ADS)

    Kremer, Bruno P.

    Welches Thema eignet sich für mein Referat oder meine Seminararbeit? Wie sammle ich Stoff? Wie gliedere ich den Text? Bruno P. Kremer beantwortet auf nur 200 Seiten alle wichtigen Fragen zur wissenschaftlichen Arbeit in den naturwissenschaftlichen Fächern. Dabei beschränkt er sich auf das für Studenten und Schüler wirklich notwendige Wissen und lässt jeglichen unnützen Ballast beiseite. Dieser praktische Ratgeber verhilft Ihnen zur erfolgreichen wissenschaftlichen Arbeit - vom Referat bis zur Examensarbeit.

  10. Wer entdeckte die Allgemeine Relativitätstheorie? Prioritätsstreit zwischen Hilbert und Einstein

    NASA Astrophysics Data System (ADS)

    Sommer, Klaus P.

    2005-09-01

    Im November 1915 arbeiteten Albert Einstein und David Hilbert an den Feldgleichungen der Gravitationstheorie. Im Jahre 1997 behaupteten die Wissenschaftshistoriker Corry, Renn und Stachel in einer viel beachteten Arbeit, Hilbert habe die entscheidenden Formeln von Einstein gestohlen. Grundlage ihrer Argumentation war eine wieder gefundene Korrekturfahne von Hilberts entscheidender Arbeit. Die Physikhistorikerin Daniela Wuensch bringt jedoch detaillierte Argumente dafür vor, dass die entscheidende Quelle, nämlich die Korrekturfahne, in neuerer Zeit manipuliert worden ist, um Einsteins Priorität unangetastet zu lassen. Einstein bleibt aber der Entdecker der Allgemeinen Relativitätstheorie.

  11. Binding-affinity predictions of HSP90 in the D3R Grand Challenge 2015 with docking, MM/GBSA, QM/MM, and free-energy simulations.

    PubMed

    Misini Ignjatović, Majda; Caldararu, Octav; Dong, Geng; Muñoz-Gutierrez, Camila; Adasme-Carreño, Francisco; Ryde, Ulf

    2016-09-01

    We have estimated the binding affinity of three sets of ligands of the heat-shock protein 90 in the D3R grand challenge blind test competition. We have employed four different methods, based on five different crystal structures: first, we docked the ligands to the proteins with induced-fit docking with the Glide software and calculated binding affinities with three energy functions. Second, the docked structures were minimised in a continuum solvent and binding affinities were calculated with the MM/GBSA method (molecular mechanics combined with generalised Born and solvent-accessible surface area solvation). Third, the docked structures were re-optimised by combined quantum mechanics and molecular mechanics (QM/MM) calculations. Then, interaction energies were calculated with quantum mechanical calculations employing 970-1160 atoms in a continuum solvent, combined with energy corrections for dispersion, zero-point energy and entropy, ligand distortion, ligand solvation, and an increase of the basis set to quadruple-zeta quality. Fourth, relative binding affinities were estimated by free-energy simulations, using the multi-state Bennett acceptance-ratio approach. Unfortunately, the results were varying and rather poor, with only one calculation giving a correlation to the experimental affinities larger than 0.7, and with no consistent difference in the quality of the predictions from the various methods. For one set of ligands, the results could be strongly improved (after experimental data were revealed) if it was recognised that one of the ligands displaced one or two water molecules. For the other two sets, the problem is probably that the ligands bind in different modes than in the crystal structures employed or that the conformation of the ligand-binding site or the whole protein changes.

  12. Binding-affinity predictions of HSP90 in the D3R Grand Challenge 2015 with docking, MM/GBSA, QM/MM, and free-energy simulations

    NASA Astrophysics Data System (ADS)

    Misini Ignjatović, Majda; Caldararu, Octav; Dong, Geng; Muñoz-Gutierrez, Camila; Adasme-Carreño, Francisco; Ryde, Ulf

    2016-09-01

    We have estimated the binding affinity of three sets of ligands of the heat-shock protein 90 in the D3R grand challenge blind test competition. We have employed four different methods, based on five different crystal structures: first, we docked the ligands to the proteins with induced-fit docking with the Glide software and calculated binding affinities with three energy functions. Second, the docked structures were minimised in a continuum solvent and binding affinities were calculated with the MM/GBSA method (molecular mechanics combined with generalised Born and solvent-accessible surface area solvation). Third, the docked structures were re-optimised by combined quantum mechanics and molecular mechanics (QM/MM) calculations. Then, interaction energies were calculated with quantum mechanical calculations employing 970-1160 atoms in a continuum solvent, combined with energy corrections for dispersion, zero-point energy and entropy, ligand distortion, ligand solvation, and an increase of the basis set to quadruple-zeta quality. Fourth, relative binding affinities were estimated by free-energy simulations, using the multi-state Bennett acceptance-ratio approach. Unfortunately, the results were varying and rather poor, with only one calculation giving a correlation to the experimental affinities larger than 0.7, and with no consistent difference in the quality of the predictions from the various methods. For one set of ligands, the results could be strongly improved (after experimental data were revealed) if it was recognised that one of the ligands displaced one or two water molecules. For the other two sets, the problem is probably that the ligands bind in different modes than in the crystal structures employed or that the conformation of the ligand-binding site or the whole protein changes.

  13. Supplementary comparison COOMET.L-S7: Standards of the unit for length (metre) in the measurement range from 0.1 mm to 100 mm

    NASA Astrophysics Data System (ADS)

    Makarevich, V.

    2012-01-01

    The COOMET Project No 390/BY/07, 'Supplementary comparison of standards of the unit for length (metre) in the measurement range from 0.1 mm to 100 mm', KCDB reference COOMET.L-S7, was organized by the Technical Committee TC 1.5 'Length and Angle' of COOMET. This comparison started in May 2007 and finished in October 2010. It was piloted by the Belarusian State Institute of Metrology BelGIM, Minsk, the Republic of Belarus, with other participants as follows: GUM (Warsaw, Poland), DP 'Ukrmetrteststandart' (Kiev, Ukraine), NSC 'Institute of Metrology' (Kharkov, Ukraine), SMU (Bratislava, Slovakia) and RSE 'KazInMetr' (Astana, Kazakhstan). The transfer standards provided by BelGIM were carried to the place of the comparison by NMI attendant specialists as personal baggage, where they were measured. The pilot laboratory processed the data obtained for the deviations of measured median lengths from the nominal lengths of the transfer standards in order to estimate the measurement result differences between the measuring instruments. The conclusion is that the equivalence of the reference installations for parameter measurements of the participating National Metrology Institutes is sufficient, and constitutes an appropriate basis for mutual recognition of measurement results. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by COOMET, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  14. CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

    SciTech Connect

    Lee, Jumin; Cheng, Xi; Swails, Jason M.; Yeom, Min Sun; Eastman, Peter K.; Lemkul, Justin A.; Wei, Shuai; Buckner, Joshua; Jeong, Jong Cheol; Qi, Yifei; Jo, Sunhwan; Pande, Vijay S.; Case, David A.; Brooks, Charles L.; MacKerell, Alexander D.; Klauda, Jeffery B.; Im, Wonpil

    2015-11-12

    Here we report that proper treatment of nonbonded interactions is essential for the accuracy of molecular dynamics (MD) simulations, especially in studies of lipid bilayers. The use of the CHARMM36 force field (C36 FF) in different MD simulation programs can result in disagreements with published simulations performed with CHARMM due to differences in the protocols used to treat the long-range and 1-4 nonbonded interactions. In this study, we systematically test the use of the C36 lipid FF in NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM. A wide range of Lennard-Jones (LJ) cutoff schemes and integrator algorithms were tested to find the optimal simulation protocol to best match bilayer properties of six lipids with varying acyl chain saturation and head groups. MD simulations of a 1,2-dipalmitoyl-sn-phosphatidylcholine (DPPC) bilayer were used to obtain the optimal protocol for each program. MD simulations with all programs were found to reasonably match the DPPC bilayer properties (surface area per lipid, chain order parameters, and area compressibility modulus) obtained using the standard protocol used in CHARMM as well as from experiments. The optimal simulation protocol was then applied to the other five lipid simulations and resulted in excellent agreement between results from most simulation programs as well as with experimental data. AMBER compared least favorably with the expected membrane properties, which appears to be due to its use of the hard-truncation in the LJ potential versus a force-based switching function used to smooth the LJ potential as it approaches the cutoff distance. The optimal simulation protocol for each program has been implemented in CHARMM-GUI. This protocol is expected to be applicable to the remainder of the additive C36 FF including the proteins, nucleic acids, carbohydrates, and small molecules.

  15. CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

    DOE PAGES

    Lee, Jumin; Cheng, Xi; Swails, Jason M.; ...

    2015-11-12

    Here we report that proper treatment of nonbonded interactions is essential for the accuracy of molecular dynamics (MD) simulations, especially in studies of lipid bilayers. The use of the CHARMM36 force field (C36 FF) in different MD simulation programs can result in disagreements with published simulations performed with CHARMM due to differences in the protocols used to treat the long-range and 1-4 nonbonded interactions. In this study, we systematically test the use of the C36 lipid FF in NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM. A wide range of Lennard-Jones (LJ) cutoff schemes and integrator algorithms were tested to find themore » optimal simulation protocol to best match bilayer properties of six lipids with varying acyl chain saturation and head groups. MD simulations of a 1,2-dipalmitoyl-sn-phosphatidylcholine (DPPC) bilayer were used to obtain the optimal protocol for each program. MD simulations with all programs were found to reasonably match the DPPC bilayer properties (surface area per lipid, chain order parameters, and area compressibility modulus) obtained using the standard protocol used in CHARMM as well as from experiments. The optimal simulation protocol was then applied to the other five lipid simulations and resulted in excellent agreement between results from most simulation programs as well as with experimental data. AMBER compared least favorably with the expected membrane properties, which appears to be due to its use of the hard-truncation in the LJ potential versus a force-based switching function used to smooth the LJ potential as it approaches the cutoff distance. The optimal simulation protocol for each program has been implemented in CHARMM-GUI. This protocol is expected to be applicable to the remainder of the additive C36 FF including the proteins, nucleic acids, carbohydrates, and small molecules.« less

  16. 1. East portal of Tunnel 3, view to west, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. East portal of Tunnel 3, view to west, 135mm lens. This tunnel was photographed to provide context, because even though somewhat enlarged, it illustrates the nature of the unlined hard rock tunnels typical of the original Central Pacific construction in 1868. - Central Pacific Transcontinental Railroad, Tunnel No. 3, Milepost 180.65, Cisco, Placer County, CA

  17. A Directory of 3660 16mm Film Libraries. Bulletin, 1959, No. 4

    ERIC Educational Resources Information Center

    Reid, Seerley; Carpenter, Anita; Daugherty, Annie Rose

    1959-01-01

    This directory is an encyclopedic compilation and includes all companies, institutions, and organizations which lend or rent 16mm films within the United States--including the 48 States, the District of Columbia, Alaska, Hawaii, and Puerto Rico--and assented to their being listed in the directory. It includes libraries which handle entertainment…

  18. Combined quantum mechanics/molecular mechanics (QM/MM) methods in computational enzymology.

    PubMed

    van der Kamp, Marc W; Mulholland, Adrian J

    2013-04-23

    Computational enzymology is a rapidly maturing field that is increasingly integral to understanding mechanisms of enzyme-catalyzed reactions and their practical applications. Combined quantum mechanics/molecular mechanics (QM/MM) methods are important in this field. By treating the reacting species with a quantum mechanical method (i.e., a method that calculates the electronic structure of the active site) and including the enzyme environment with simpler molecular mechanical methods, enzyme reactions can be modeled. Here, we review QM/MM methods and their application to enzyme-catalyzed reactions to investigate fundamental and practical problems in enzymology. A range of QM/MM methods is available, from cheaper and more approximate methods, which can be used for molecular dynamics simulations, to highly accurate electronic structure methods. We discuss how modeling of reactions using such methods can provide detailed insight into enzyme mechanisms and illustrate this by reviewing some recent applications. We outline some practical considerations for such simulations. Further, we highlight applications that show how QM/MM methods can contribute to the practical development and application of enzymology, e.g., in the interpretation and prediction of the effects of mutagenesis and in drug and catalyst design.

  19. Construction of exchange repulsion in terms of the wave functions at QM/MM boundary region

    SciTech Connect

    Takahashi, Hideaki Umino, Satoru; Morita, Akihiro

    2015-08-28

    We developed a simple method to calculate exchange repulsion between a quantum mechanical (QM) solute and a molecular mechanical (MM) molecule in the QM/MM approach. In our method, the size parameter in the Buckingham type potential for the QM solute is directly determined in terms of the one-electron wave functions of the solute. The point of the method lies in the introduction of the exchange core function (ECF) defined as a Slater function which mimics the behavior of the exterior electron density at the QM/MM boundary region. In the present paper, the ECF was constructed in terms of the Becke-Roussel (BR) exchange hole function. It was demonstrated that the ECF yielded by the BR procedure can faithfully reproduce the radial behavior of the electron density of a QM solute. The size parameter of the solute as well as the exchange repulsion are, then, obtained using the overlap model without any fitting procedure. To examine the efficiency of the method, it was applied to calculation of the exchange repulsions for minimal QM/MM systems, hydrogen-bonded water dimer, and H{sub 3}O{sup +}–H{sub 2}O. We found that our approach is able to reproduce the potential energy curves for these systems showing reasonable agreements with those given by accurate full quantum chemical calculations.

  20. THE RADIO-2 mm SPECTRAL INDEX OF THE CRAB NEBULA MEASURED WITH GISMO

    SciTech Connect

    Arendt, R. G.; George, J. V.; Staguhn, J. G.; Benford, D. J.; Fixsen, D. J.; Maher, S. F.; Moseley, S. H.; Sharp, E.; Wollack, E. J.; Devlin, M. J.; Dicker, S. R.; Korngut, P. M.; Irwin, K. D.; Jhabvala, C. A.; Miller, T. M.; Kovacs, A.; Mason, B. S.; Navarro, S.; Sievers, A.; Sievers, J. L.

    2011-06-10

    We present results of 2 mm observations of the Crab Nebula, obtained using the Goddard-IRAM Superconducting 2 Millimeter Observer (GISMO) bolometer camera on the IRAM 30 m telescope. Additional 3.3 mm observations with the MUSTANG bolometer array on the Green Bank Telescope are also presented. The integrated 2 mm flux density of the Crab Nebula provides no evidence for the emergence of a second synchrotron component that has been proposed. It is consistent with the radio power-law spectrum, extrapolated up to a break frequency of log ({nu}{sub b}[GHz]) = 2.84 {+-} 0.29 or {nu}{sub b} = 695{sup +651}{sub -336} GHz. The Crab Nebula is well resolved by the {approx}16.''7 beam (FWHM) of GISMO. Comparison to radio data at comparable spatial resolution enables us to confirm significant spatial variation of the spectral index between 21 cm and 2 mm. The main effect is a spectral flattening in the inner region of the Crab Nebula, correlated with the toroidal structure at the center of the nebula that is prominent in the near-IR through X-ray regime.

  1. 3. West portal of Tunnel 18, view to northeast, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. West portal of Tunnel 18, view to northeast, 135mm lens. Note the use of concrete face and wingwalls, with dressed stone voussoirs, wingwall coping, parapet with stone belt course and coping, and coursed stone masonry slope protection flanking the portal. - Southern Pacific Railroad Natron Cutoff, Tunnel No. 17, Milepost 408, Dorris, Siskiyou County, CA

  2. THE ENIGMATIC CORE L1451-mm: A FIRST HYDROSTATIC CORE? OR A HIDDEN VeLLO?

    SciTech Connect

    Pineda, Jaime E.; Goodman, Alyssa A.; Bourke, Tyler; Foster, Jonathan B.; Robitaille, Thomas; Kauffmann, Jens; Arce, Hector G.; Tanner, Joel; Schnee, Scott; Tafalla, Mario; Caselli, Paola; Anglada, Guillem

    2011-12-20

    We present the detection of a dust continuum source at 3 mm (CARMA) and 1.3 mm (Submillimeter Array, SMA), and {sup 12}CO (2-1) emission (SMA) toward the L1451-mm dense core. These detections suggest a compact object and an outflow where no point source at mid-infrared wavelengths is detected using Spitzer. An upper limit for the dense core bolometric luminosity of 0.05 L{sub Sun} is obtained. By modeling the broadband spectral energy distribution and the continuum interferometric visibilities simultaneously, we confirm that a central source of heating is needed to explain the observations. This modeling also shows that the data can be well fitted by a dense core with a young stellar object (YSO) and a disk, or by a dense core with a central first hydrostatic core (FHSC). Unfortunately, we are not able to decide between these two models, which produce similar fits. We also detect {sup 12}CO (2-1) emission with redshifted and blueshifted emission suggesting the presence of a slow and poorly collimated outflow, in opposition to what is usually found toward YSOs but in agreement with prediction from simulations of an FHSC. This presents the best candidate, so far, for an FHSC, an object that has been identified in simulations of collapsing dense cores. Whatever the true nature of the central object in L1451-mm, this core presents an excellent laboratory to study the earliest phases of low-mass star formation.

  3. A shallow convection parameterization for the non-hydrostatic MM5 mesoscale model

    SciTech Connect

    Seaman, N.L.; Kain, J.S.; Deng, A.

    1996-04-01

    A shallow convection parameterization suitable for the Pennsylvannia State University (PSU)/National Center for Atmospheric Research nonhydrostatic mesoscale model (MM5) is being developed at PSU. The parameterization is based on parcel perturbation theory developed in conjunction with a 1-D Mellor Yamada 1.5-order planetary boundary layer scheme and the Kain-Fritsch deep convection model.

  4. The M&M Approach: Using Mental and Mechanical Strategies in Teaching and Coaching

    ERIC Educational Resources Information Center

    Rhea, Chris K.; Wisdom, Stacey

    2007-01-01

    Mental and mechanical (M&M) techniques are very useful in teaching and coaching. Mental techniques are strategies that enhance movement through psychological preparation, such as using imagery to practice a skill. Mechanical techniques are strategies that enhance the physical side of the movement, such as correcting the biomechanics of a golf…

  5. Multiple-steering QM-MM calculation of the free energy profile in chorismate mutase.

    PubMed

    Crespo, Alejandro; Martí, Marcelo A; Estrin, Darío A; Roitberg, Adrian E

    2005-05-18

    A novel technique for computing free energy profiles in enzymatic reactions using the multiple steering molecular dynamics approach in the context of an efficient QM-MM density functional scheme is presented. The conversion reaction of chorismate to prephenate catalyzed by the Bacillus subtilis enzyme chorismate mutase has been chosen as an illustrative example.

  6. 14. Main room; view no southwest, 65mm lens with electronic ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Main room; view no southwest, 65mm lens with electronic flash illumination. The mountain visible through the windows was a landmark for the camp population. - Tule Lake Project Jail, Post Mile 44.85, State Route 139, Newell, Modoc County, CA

  7. A Microconduit Flow Injection Analysis Demonstration Using a 35-mm Slide Projector.

    ERIC Educational Resources Information Center

    McKelvie, Ian D.; And Others

    1990-01-01

    Described is a 35mm projector demonstration which combines the advantages a highly magnified view of the sample zone as it undergoes dispersion and the ability to show more than a single-line flow injection analysis manifold. Manufacture and use of the slide for demonstration are discussed. (CW)

  8. VLSI corrector chip for space-borne mm-wave radiometer spectrometers

    NASA Technical Reports Server (NTRS)

    Chandra, K.; Tarsala, J.; Pickett, H.; Wilson, W.

    1990-01-01

    JPL developed a 52-channel 150 MHz bandwidth autocorrelator spectrometer using specially designed ECL gate array correlator chips. The characteristics of the ECL chip and the 52-channel auto-correlator are described. These autocorrelator spectrometers will be used with space-borne mm-wave radiometers for remote sensing of the Earth's atmosphere and astrophysical observations.

  9. MAPPING GREEN MACROALGAE BLOOMS IN A PACIFIC NORTHWEST ESTUARY VIA 35-MM AERIAL PHOTOS

    EPA Science Inventory

    Summer blooms of green macroalgae (mainly Ulva spp. and Enteromorpha spp.) on intertidal mudflats of Oregon's Yaquina Bay estuary were documented using oblique 35-mm color-infrared aerial photographs taken at low tide. Costs were controlled by use of a small airplane from a loc...

  10. 10. Southeast end; view to northwest, 65mm lens. Note evidence ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Southeast end; view to northwest, 65mm lens. Note evidence of extreme building failure caused by adjacent railroad cut, which necessitated building demolition. (Vignetting due to extreme use of camera swing necessitated by lack of space to position camera otherwise.) - Benicia Arsenal, Powder Magazine No. 5, Junction of Interstate Highways 680 & 780, Benicia, Solano County, CA

  11. Comments on the papers recently published by M.M. Khandpekar et al.

    NASA Astrophysics Data System (ADS)

    Petrosyan, A. M.; Ghazaryan, V. V.; Fleck, M.

    2011-09-01

    It is argued that the existence of the new compounds of glycine recently reported by M.M. Khandpekar et al. (Optics Commun. 284(2011) 1583 and Optics Commun. 284(2011) 1578) is dubious. We argue that these compounds are not what the authors propose. In addition, two more similar cases are indicated.

  12. Technical Manual for Attitudes Towards Teaching All Students (ATTAS-mm) Instrument

    ERIC Educational Resources Information Center

    Gregory, Jess L.; Noto, Lori A.

    2012-01-01

    The general education teacher has the greatest influence on a student's success in school, and a teacher's attitude towards inclusion is a major factor in determining whether inclusion will be successful. The ATTAS-mm is a 9-item scale with strong reliability and validity. The three subscales: believing all students can succeed in general…

  13. Proton and hydride transfers in solution: hybrid QMmm/MM free energy perturbation study

    SciTech Connect

    Ho, L. Lawrence |; Bash, P.A.; Kerell, A.D., Jr

    1996-03-01

    A hybrid quantum and molecular mechanical (QM/MM) free energy perturbation (FEP) method is implemented in the context of molecular dynamics (MD). The semiempirical quantum mechanical (QM) Hamiltonian (Austin Model 1) represents solute molecules, and the molecular mechanical (MM) CHARMM force field describes the water solvent. The QM/MM FEP method is used to calculate the free energy changes in aqueous solution for (1) a proton transfer from methanol to imidazole and (2) a hydride transfer from methoxide to nicotinamide. The QM/MM interaction energies between the solute and solvent arc calibrated to emulate the solute-solvent interaction energies determined at the Hartee-Fock 6-31G(d) level of ab initio theory. The free energy changes for the proton and hydride transfers are calculated to be 15.1 and {minus}6.3 kcal/mol, respectively, which compare favorably with the corresponding experimental values of 12.9 and {minus}7.4 kcal/mol. An estimate of the reliability of the calculations is obtained through the computation of the forward (15.1 and {minus}6.3 kcal/mol) and backward ({minus}14.1 and 9.1 kcal/mol)free energy changes. The reasonable correspondence between these two independent calculations suggests that adequate phase space sampling is obtained along the reaction pathways chosen to transform the proton and hydride systems between their respective reactant and product states.

  14. Development of buffer layers on 30 mm wide textured metal substrates for REBCO coated conductors

    NASA Astrophysics Data System (ADS)

    Yamaguchi, T.; Ota, H.; Ohki, K.; Konishi, M.; Ohmatsu, K.

    2010-11-01

    We have been studying REBa2Cu3Ox (RE: rare earth elements) coated conductors on clad-type substrates. We developed coated conductors on the 10 mm wide clad-type tape, and succeeded in obtaining the maximum critical current of 380 A/cm with the 2.0 μm thick GdBa2Cu3Ox superconducting film. At present, we are trying to widen the tape width from 10 mm to 30 mm in order to increase production throughput. We report our recent progress on scaling-up of the buffer layers and their properties. The buffer layers consisted of three layers; CeO2 as the seed layer, yttrium-stabilized zirconia (YSZ) as the diffusion barrier layer and CeO2 as the lattice matching layer. They were grown by the RF-sputtering method and the electron beam evaporation technique (EB). EB deposition has possibility of higher throughput compared with the RF-sputtering. The intensity ratio of (2 0 0) to (2 0 0) + (1 1 1) for the lattice matching layer showed as high as 98%. The uniform properties of 40 m long and 30 mm wide substrates were successfully produced by all sputtering method. Additionally, the tape travel speed of the seed layer can be increased from 7 m/h (RF-sputtering deposition) to 10 m/h (EB deposition) on short sample (0.3 m long).

  15. USING MM5V3 WITH ETA ANALYSES FOR AIR-QUALITY MODELING AT THE EPA

    EPA Science Inventory

    Efforts have been underway since MM5v3 was released in July 1999 to set up air-quality simulations using Eta analyses as background fields. Our previous simulations used a one-way quadruple-nested set of domains with horizontal grid spacing of 108, 36, 12 and 4 km. With Eta a...

  16. 16mm Film and Videotape Lectures and Demonstrations. 1976/1977 Catalog.

    ERIC Educational Resources Information Center

    Massachusetts Inst. of Tech., Cambridge. Center for Advanced Engineering Study.

    The Massachusetts Institute of Technology provides a catalog of 16mm filmed and videotaped lectures and demonstrations. Each listing includes title, short description, length of presentation, catalog number, purchase and rental prices, and indications as to whether the item is film or videotape and black-and-white or color. The catalog is divided…

  17. 32. VERTICAL OSCILLATIONS, 3/4 VIEW, 7 NOVEMBER 1940, FROM 16MM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. VERTICAL OSCILLATIONS, 3/4 VIEW, 7 NOVEMBER 1940, FROM 16MM FILM SHOT PROFESSOR F.B. FARQUHARSON, UNIVERSITY OF WASHINGTON. (LABORATORY STUDIES ON THE TACOMA NARROWS BRIDGE, AT UNIVERSITY OF WASHINGTON (SEATTLE: UNIVERSITY OF WASHINGTON, DEPARTMENT OF CIVIL ENGINEERING, 1941) - Tacoma Narrows Bridge, Spanning Narrows at State Route 16, Tacoma, Pierce County, WA

  18. Detail, typical window fenestrations, east façade, view to westnorthwest (135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail, typical window fenestrations, east façade, view to west-northwest (135mm lens). Note "timber" header, adobe bench in front of window. - Burton Park, Club House & Amphitheater, Adjacent ot south end of Chestnut Avenue, San Carlos, San Mateo County, CA

  19. 3. West portal of Tunnel 26, view to northeast, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. West portal of Tunnel 26, view to northeast, 135mm lens. Note use of granite voussoirs and coping on this otherwise all-reinforced concrete structure. - Central Pacific Transcontinental Railroad, Tunnel No. 26, Milepost 133.29, Applegate, Placer County, CA

  20. U.S. Atomic Energy Commission 16 mm Classroom Films on Nuclear Science.

    ERIC Educational Resources Information Center

    Akers, Lawrence K.; Brannon, Troy

    Fifty-seven selected 16mm films are listed under the headings: General Interest Films, General Science Films, Physics Films, Chemistry Films, and Biology Films. The listing of each film includes a brief description of content and recommended grade levels. References are given to booklets in The Atomic Energy Commission's "Understanding the…

  1. 9 mm ammunition used in a 40 caliber glock pistol: an atypical gunshot wound.

    PubMed

    Thogmartin, J R; Start, D A

    1998-05-01

    Atypical gunshot wounds due to ricochet and intermediate targets have been well described in the literature. We represent a case of suicide with an atypical entrance wound and bullet without rifling marks due to 9 mm ammunition being loaded and fired from a 40 caliber semiautomatic pistol.

  2. Carcinoma in situ in a 7 mm gallbladder polyp: Time to change current practice?

    PubMed

    Kasle, David; Rahnemai-Azar, Amir A; Bibi, Shahida; Gaduputi, Vinaya; Gilchrist, Brian F; Farkas, Daniel T

    2015-07-25

    Detection of polypoid lesions of the gallbladder is increasing in conjunction with better imaging modalities. Accepted management of these lesions depends on their size and symptomatology. Polyps that are symptomatic and/or greater than 10 mm are generally removed, while smaller, asymptomatic polyps simply monitored. Here, a case of carcinoma-in-situ is presented in a 7 mm gallbladder polyp. A 25-year-old woman, who had undergone a routine cholecystectomy, was found to have an incidental 7 mm polyp containing carcinoma in situ. She had few to no risk factors to alert to her condition. There are few reported cases of cancer transformation in gallbladder polyps smaller than 10 mm reported in the literature. The overwhelming consensus, barring significant risk factors for cancer being present, is that such lesions should be monitored until they become symptomatic or develop signs suspicious for malignancy. In our patient's case this could have led to the possibility of missing a neoplastic lesion, which could then have gone on to develop invasive cancer. As gallbladder carcinoma is an aggressive cancer, this may have led to a tragic outcome.

  3. Development of mm2-size high energy resolution X-ray detectors using W-SPT

    NASA Astrophysics Data System (ADS)

    Angloher, G.; Bento, A.; Kraus, H.; Pröbst, F.; Seidel, W.

    2002-02-01

    The low transition temperature of tungsten should allow fabrication of X-ray detectors combining high-energy resolution and enlarged absorber area (~1 mm2). We present first results obtained for lead and gold absorbers read out by tungsten superconducting phase transition thermometers (W-SPT) using a variety of detector geometries. .

  4. 2. West portal of Snowshed 29, view to east, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. West portal of Snowshed 29, view to east, 135mm lens. Note the heavy timber frame, with battered posts to carry the tremendous snow loads of winter. - Central Pacific Transcontinental Railroad, Tunnel No. 41, Milepost 193.3, Donner, Placer County, CA

  5. 5. East portal of Tunnel 28, view to southsouthwest, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. East portal of Tunnel 28, view to south-southwest, 135mm lens. Shed above portal appears to have housed machinery connected with a counterweighted curtain mechanism used to help dissipate smoke from this 3,209-foot tunnel during the days of steam locomotive use - Central Pacific Transcontinental Railroad, Tunnel No. 28, Milepost 134.75, Applegate, Placer County, CA

  6. 2. West portal of Tunnel 1, view to northeast, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. West portal of Tunnel 1, view to northeast, 135mm lens. Like the new tunnels built during this period, Tunnel 1 received a new concrete portal face with granite masonry voussoirs and coping. - Central Pacific Transcontinental Railroad, Tunnel No. 1, Milepost 164.34, Blue Canyon, Placer County, CA

  7. 5. East portal of Tunnel 18, view to westsouthwest, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. East portal of Tunnel 18, view to west-southwest, 135mm lens. The train exiting the tunnel, though northbound toward Portland, is considered an eastbound train on the Southern Pacific (see explanation above). - Southern Pacific Railroad Natron Cutoff, Tunnel No. 18, Milepost 410, Dorris, Siskiyou County, CA

  8. 3. East portal of Tunnel 34, view to southsouthwest, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. East portal of Tunnel 34, view to south-southwest, 135mm lens with electronic flash fill. Note the shift, in these later tunnels east of Colfax, to concrete portal faces with granite masonry voussoirs and coping. - Central Pacific Transcontinental Railroad, Tunnel No. 34, Milepost 145.4, Colfax, Placer County, CA

  9. CVB: The Constrained Vapor Bubble 40 mm Capillary Experiment on the ISS

    NASA Technical Reports Server (NTRS)

    Wayner, Peter C., Jr.; Kundan, Akshay; Plawsky, Joel

    2013-01-01

    Discuss the Constrained Vapor Bubble (CVB) 40mm Fin experiment on the ISS and how it aims to achieve a better understanding of the physics of evaporation and condensation and how they affect cooling processes in microgravity using a remotely controlled microscope and a small cooling device

  10. Radiosurgery With or Without A 2-mm Margin for 93 Single Brain Metastases

    SciTech Connect

    Nataf, Francois; Schlienger, Michel Liu Zhihua; Foulquier, Jean Noel; Gres, Benoit; Orthuon, Alexandre; Vannetzel, Jean Michel; Escudier, Bernard; Meder, Jean- Francois; Roux, Francois Xavier; Touboul, Emmanuel

    2008-03-01

    Purpose: Retrospective comparison of Linac radiosurgery (RS) in 93 single brain metastases with or without a 2-mm margin. Patients and Methods: A total of 153 patients had Linac RS (between April 1992 and June 2004), with 139 patients (90.8%) evaluable in June 2005. Sixty-one patients (44%) had extracranial lesions and 65 patients had neurologic symptoms (47%). RS alone: 105 patients (66%); RS +whole brain radiotherapy: 34 patients (24%). Single metastasis: 93/139 patients; classic RS: 42/93 patients; 2-mm margin: 51/93 patients; 30 multiple lesions patients were excluded. Treatment: 15 Mv X-ray Linac, circular minibeams, 8-30 mm, four to six noncoplanar coronal arcs. Isodose was 60-80%; doses were 10-20 Gy. Follow-up: 12 months-13 years; median, 14 months. Results: Local control (LC) was not improved in 51 margin patients vs. 42 classic RS patients: 1 year: 69.1% and 72.4%. Two-year LC rate: 64% and 54.7%, respectively. Survival: median classic RS: 11.3 months; margin RS, 19 months (p = 0.34) and 1 year, 41.6% and 60.2%, respectively. Margin RS patients had a significantly higher rate of severe parenchymal complications: 19.6% vs. 7.1% (p = 0.02); surgery was necessary in 4 of 51 cases vs. 1 of 42 classic RS cases. Conclusion: No increase of 1- and 2-year LC rate in margin RS or survival and median survival: 11.3 vs. 19 months (NS) 2-mm margin associated with more severe parenchymal complications (p = 0.02).This procedure is therefore not recommended. Late CT images and 1-mm margin as recommended by pathologists, use of three-dimensional magnetic resonance imaging and fuzzy method to calculate volumes may yield better results. Stereotactic hypofractionation requires further studies.

  11. Sampling efficiency of modified 37-mm sampling cassettes using computational fluid dynamics.

    PubMed

    Anthony, T Renée; Sleeth, Darrah; Volckens, John

    2016-01-01

    In the U.S., most industrial hygiene practitioners continue to rely on the closed-face cassette (CFC) to assess worker exposures to hazardous dusts, primarily because ease of use, cost, and familiarity. However, mass concentrations measured with this classic sampler underestimate exposures to larger particles throughout the inhalable particulate mass (IPM) size range (up to aerodynamic diameters of 100 μm). To investigate whether the current 37-mm inlet cap can be redesigned to better meet the IPM sampling criterion, computational fluid dynamics (CFD) models were developed, and particle sampling efficiencies associated with various modifications to the CFC inlet cap were determined. Simulations of fluid flow (standard k-epsilon turbulent model) and particle transport (laminar trajectories, 1-116 μm) were conducted using sampling flow rates of 10 L min(-1) in slow moving air (0.2 m s(-1)) in the facing-the-wind orientation. Combinations of seven inlet shapes and three inlet diameters were evaluated as candidates to replace the current 37-mm inlet cap. For a given inlet geometry, differences in sampler efficiency between inlet diameters averaged less than 1% for particles through 100 μm, but the largest opening was found to increase the efficiency for the 116 μm particles by 14% for the flat inlet cap. A substantial reduction in sampler efficiency was identified for sampler inlets with side walls extending beyond the dimension of the external lip of the current 37-mm CFC. The inlet cap based on the 37-mm CFC dimensions with an expanded 15-mm entry provided the best agreement with facing-the-wind human aspiration efficiency. The sampler efficiency was increased with a flat entry or with a thin central lip adjacent to the new enlarged entry. This work provides a substantial body of sampling efficiency estimates as a function of particle size and inlet geometry for personal aerosol samplers.

  12. Brown dwarf disks with Herschel: Linking far-infrared and (sub)-mm fluxes

    NASA Astrophysics Data System (ADS)

    Daemgen, Sebastian; Natta, Antonella; Scholz, Alexander; Testi, Leonardo; Jayawardhana, Ray; Greaves, Jane; Eastwood, Daniel

    2016-10-01

    Brown dwarf disks are excellent laboratories to test our understanding of disk physics in an extreme parameter regime. In this paper we investigate a sample of 29 well-characterized brown dwarfs and very low-mass stars, for which Herschel far-infrared fluxes and (sub)-mm fluxes are available. We measured new Herschel/PACS fluxes for 11 objects and complement these with (sub)-mm data and Herschel fluxes from the literature. We analyze their spectral energy distributions in comparison with results from radiative transfer modeling. Fluxes in the far-infrared are strongly affected by the shape and temperature of the disk (and hence stellar luminosity), whereas the (sub)-mm fluxes mostly depend on disk mass. Nevertheless, there is a clear correlation between far-infrared and (sub)-mm fluxes. We argue that the link results from the combination of the stellar mass-luminosity relation and a scaling between disk mass and stellar mass. We find strong evidence of dust settling to the disk midplane. The spectral slopes between near- and far-infrared are mostly between -0.5 and -1.2 in our sample, which is comparable to more massive T Tauri stars; this may imply that the disk shapes are similar as well, although highly flared disks are rare among brown dwarfs. We find that dust temperatures in the range of 7-15 K, calculated with T ≈ 25 (L/L⊙)0.25 K, are appropriate for deriving disk masses from (sub)-mm fluxes for these low luminosity objects. About half of our sample hosts disks with at least one Jupiter mass, confirming that many brown dwarfs harbor sufficient material for the formation of Earth-mass planets in their midst. Herschel is a ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.

  13. Antiproliferative and Antiangiogenic Effects of Punica granatum Juice (PGJ) in Multiple Myeloma (MM).

    PubMed

    Tibullo, Daniele; Caporarello, Nunzia; Giallongo, Cesarina; Anfuso, Carmelina Daniela; Genovese, Claudia; Arlotta, Carmen; Puglisi, Fabrizio; Parrinello, Nunziatina L; Bramanti, Vincenzo; Romano, Alessandra; Lupo, Gabriella; Toscano, Valeria; Avola, Roberto; Brundo, Maria Violetta; Di Raimondo, Francesco; Raccuia, Salvatore Antonio

    2016-10-01

    Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of clonal plasma cells (PC) in the bone marrow (BM) leading to bone destruction and BM failure. Despite recent advances in pharmacological therapy, MM remains a largely incurable pathology. Therefore, novel effective and less toxic agents are urgently necessary. In the last few years, pomegranate has been studied for its potential therapeutic properties including treatment and prevention of cancer. Pomegranate juice (PGJ) contains a number of potential active compounds including organic acids, vitamins, sugars, and phenolic components that are all responsible of the pro-apoptotic effects observed in tumor cell line. The aim of present investigation is to assess the antiproliferative and antiangiogenic potential of the PGJ in human multiple myeloma cell lines. Our data demonstrate the anti-proliferative potential of PGJ in MM cells; its ability to induce G0/G1 cell cycle block and its anti-angiogenic effects. Interestingly, sequential combination of bortezomib/PGJ improved the cytotoxic effect of the proteosome inhibitor. We investigated the effect of PGJ on angiogenesis and cell migration/invasion. Interestingly, we observed an inhibitory effect on the tube formation, microvessel outgrowth aorting ring and decreased cell migration and invasion as showed by wound-healing and transwell assays, respectively. Analysis of angiogenic genes expression in endothelial cells confirmed the anti-angiogenic properties of pomegranate. Therefore, PGJ administration could represent a good tool in order to identify novel therapeutic strategies for MM treatment, exploiting its anti-proliferative and anti-angiogenic effects. Finally, the present research supports the evidence that PGJ could play a key role of a future therapeutic approach for treatment of MM in order to optimize the pharmacological effect of bortezomib, especially as adjuvant after treatment.

  14. Antiproliferative and Antiangiogenic Effects of Punica granatum Juice (PGJ) in Multiple Myeloma (MM)

    PubMed Central

    Tibullo, Daniele; Caporarello, Nunzia; Giallongo, Cesarina; Anfuso, Carmelina Daniela; Genovese, Claudia; Arlotta, Carmen; Puglisi, Fabrizio; Parrinello, Nunziatina L.; Bramanti, Vincenzo; Romano, Alessandra; Lupo, Gabriella; Toscano, Valeria; Avola, Roberto; Brundo, Maria Violetta; Di Raimondo, Francesco; Raccuia, Salvatore Antonio

    2016-01-01

    Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of clonal plasma cells (PC) in the bone marrow (BM) leading to bone destruction and BM failure. Despite recent advances in pharmacological therapy, MM remains a largely incurable pathology. Therefore, novel effective and less toxic agents are urgently necessary. In the last few years, pomegranate has been studied for its potential therapeutic properties including treatment and prevention of cancer. Pomegranate juice (PGJ) contains a number of potential active compounds including organic acids, vitamins, sugars, and phenolic components that are all responsible of the pro-apoptotic effects observed in tumor cell line. The aim of present investigation is to assess the antiproliferative and antiangiogenic potential of the PGJ in human multiple myeloma cell lines. Our data demonstrate the anti-proliferative potential of PGJ in MM cells; its ability to induce G0/G1 cell cycle block and its anti-angiogenic effects. Interestingly, sequential combination of bortezomib/PGJ improved the cytotoxic effect of the proteosome inhibitor. We investigated the effect of PGJ on angiogenesis and cell migration/invasion. Interestingly, we observed an inhibitory effect on the tube formation, microvessel outgrowth aorting ring and decreased cell migration and invasion as showed by wound-healing and transwell assays, respectively. Analysis of angiogenic genes expression in endothelial cells confirmed the anti-angiogenic properties of pomegranate. Therefore, PGJ administration could represent a good tool in order to identify novel therapeutic strategies for MM treatment, exploiting its anti-proliferative and anti-angiogenic effects. Finally, the present research supports the evidence that PGJ could play a key role of a future therapeutic approach for treatment of MM in order to optimize the pharmacological effect of bortezomib, especially as adjuvant after treatment. PMID:27706074

  15. Rapid Enhanced MM3-COPRO ELISA for Detection of Fasciola Coproantigens

    PubMed Central

    Martínez-Sernández, Victoria; Orbegozo-Medina, Ricardo A.; González-Warleta, Marta; Mezo, Mercedes; Ubeira, Florencio M.

    2016-01-01

    ELISA-based methods of detecting Fasciola cathepsins in feces are powerful techniques for diagnosing infections by F. hepatica and F. gigantica. In the last decade, the in-house MM3-COPRO ELISA and its commercial version BIO K 201 (BIO X Diagnostics, Belgium) have been recognized as useful tools for detecting early infections by such trematodes and for monitoring the efficacy of anthelmintic treatments in human and animal species, as they provide some advantages over classic fecal egg counts. However, the sensitivity of MM3-COPRO ELISA can sometimes be compromised by the high variability in the concentration of cathepsins in fecal samples throughout the biological cycle of Fasciola (mainly in cattle) and by differences in the between-batch performance of peroxidase-labeled anti-mouse IgG polyclonal antibodies. To prevent such problems, we investigated whether the incorporation of a commercial streptavidin-polymerized horseradish peroxidase conjugate, in order to reveal bound biotinylated monoclonal antibody MM3, can improve the sensitivity of the MM3-COPRO ELISA. We observed that inclusion of this reagent shifted the previous detection limit of the assay from 0.6 ng/mL to 150 pg/mL and that the modified test is able to identify infection in cows harboring only one fluke. Moreover, we demonstrated that maximal OD values can be achieved with short incubations (30 min each step) at RT with shaking, rather than standard incubations, which significantly accelerates the diagnostic procedure. Finally, we did not find a significant correlation between coproantigen concentration and parasite burden in cattle, which may be due to the low parasite burden (1–10 adult flukes) of the animals used in the present study. As the usefulness of the classic MM3-COPRO test for detecting animal and human infections has already been demonstrated, it is expected that the improvements reported in this study will add new insights into the diagnosis and control of fasciolosis. PMID:27438470

  16. Surgical Management of Tibial Plateau Fractures With 3.5 mm Simple Plates

    PubMed Central

    Bagherifard, Abolfazl; Jabalameli, Mahmoud; Hadi, Hosseinali; Rahbar, Mohammad; Minator Sajjadi, Mohammadreza; Jahansouz, Ali; Karimi Heris, Hossein

    2016-01-01

    Background Tibial plateau fractures can be successfully fixed utilizing 3.5 mm locking plates. However, there are some disadvantages to using these plates. Objectives In the current prospective study, we investigated the outcome of treating different types of tibial plateau fractures with 3.5 mm simple plates which, to our knowledge, has not been evaluated in previous studies. Materials and Methods Between 2011 and 2013, 32 patients aged 40 ± 0.2 years underwent open reduction and internal fixation for tibial plateau fractures with 3.5 mm simple plates. The patients were followed for 16.14 ± 2.1 months. At each patient’s final visit, the articular surface depression, medial proximal tibial angle, and slope angle were measured and compared with measurements taken early after the operation. The functional outcomes were measured with the WOMAC and Lysholm knee scores. Results The mean union time was 13 ± 1.2 weeks. The mean knee range of motion was 116.8° ± 3.3°. The mean WOMAC and Lysholm scores were 83.5 ± 1.8 and 76.8 ± 1.6, respectively. On the early postoperative and final X-rays, 87.5% and 84% of patients, respectively, had acceptable reduction. Medial proximal tibial and slope angles did not change significantly by the last visit. No patient was found to have complications related to the type of plate. Conclusions In this case series study, the fixation of different types of tibial plateau fractures with 3.5 mm simple non-locking and non-precontoured plates was associated with acceptable clinical, functional, and radiographic outcomes. Based on the advantages and costs of these plates, the authors recommend using 3.5 mm simple plates for different types of tibial plateau fractures. PMID:27626010

  17. Physik gestern und heute Suprafluidität - Von den Schwierigkeiten einer Messung

    NASA Astrophysics Data System (ADS)

    Sichau, Christian

    2003-03-01

    Der Vater der Tieftemperaturphysik, Heike Kammerlingh Onnes, benötigte zu Beginn des 20. Jahrhunderts für die Verflüssigung von wenigen Litern Heliums noch mehrere Jahre, eine riesige Apparatur und viel Geld. Heute gelingt dies routinemäßig. Die Untersuchung der Materie bei tiefen Temperaturen, insbesondere zur Suprafluidität, bietet viele Überraschungen.

  18. Rosazea-Management: Update über allgemeine Maßnahmen und topische Therapieoptionen.

    PubMed

    Schaller, M; Schöfer, H; Homey, B; Hofmann, M; Gieler, U; Lehmann, P; Luger, T A; Ruzicka, T; Steinhoff, M

    2016-12-01

    Obwohl bislang für die Rosazea keine kurative Therapie besteht, können verschiedene Optionen zur Behandlung der Symptome und zur Vorbeugung von Exazerbationen empfohlen werden. Neben Selbsthilfemaßnahme wie der Vermeidung von Triggerfaktoren und einer geeigneten Hautpflege sollte das Rosazea-Management bei Patienten mit erythematöser und leichter bis schwerer papulopustulöser Rosazea die Anwendung topischer Präparate als First-Line-Therapie umfassen. Da Überlappungen der charakteristischen Rosazea-Symptome im klinischen Alltag die Regel sind, sollte die medikamentöse Therapie auf die individuellen Symptome zugeschnitten werden; auch eine Kombinationstherapie kann erforderlich sein. Zu den für die Behandlung der Hauptsymptome der Rosazea zugelassenen Wirkstoffen gehören Brimonidin gegen das Erythem sowie Ivermectin, Metronidazol oder Azelainsäure gegen entzündliche Läsionen. Ihre Wirksamkeit wurde in zahlreichen validen, gut kontrollierten Studien belegt. Darüber hinaus existieren verschiedene nicht zugelassene topische Behandlungsmöglichkeiten, deren Wirksamkeit und Sicherheit noch in größeren, kontrollierten Studien zu untersuchen ist.

  19. Matthias Falter und die frühe Halbleitertechnik in der DDR

    NASA Astrophysics Data System (ADS)

    Dittmann, Frank

    Nach einer ganzen Reihe von Vorarbeiten weltweit1 konnten im Dezember 1947 die amerikanischen Physiker Walter H. Brattain, John Bardeen und William Shockley in den Bell Laboratories den Transistoreffekt demonstrieren. Damit legten sie den Grundstein für die Mikroelektronik als Basistechnologie des Informationszeitalters.

  20. HELGA: The Herschel Exploitation of the Local Galaxy Andromeda: Sub-mm Morphology and Dust Properties

    NASA Astrophysics Data System (ADS)

    Fritz, J.; Smith, M. W. L.; Kirk, J.; Helga Collaboration

    2014-03-01

    The results from a large-field Far-Infrared (FIR) and sub-millimeter (sub-mm) survey of our neighbor galaxy M31 are presented. We have obtained Herschel images of a ˜ 5.5 × 2.5 degree area centered on Andromeda. Using 21-cm atomic hydrogen maps, we are able to disentangle genuine emission from M31 from that for foreground Galactic cirrus, allowing us to recognize dusty structures out to ˜ 31 kpc from the center. We first characterize the FIR and sub-mm morphology and then, by de-projecting Herschel maps and running an ad-hoc source extraction algorithm, we reconstruct the intrinsic morphology and the spatial distribution of the molecular complexes. Finally, we study the spatially resolved properties of the dust (temperature, emissivity, mass, etc.) by means of a pixel-by-pixel SED fitting approach.

  1. Estimating the shooting distance of a 9-mm Parabellum bullet via ballistic experiment.

    PubMed

    Bresson, F; Franck, O

    2009-11-20

    We demonstrate here how the shooting distance of a 9-mm Parabellum FMJ bullet (115gr) has been estimated via shooting experiments. Such a bullet was found by investigators near a concrete wall, fairly distorted at its tip. The bullet carries no evidence of multiple impact and no evidence of ballistic impact on the wall has been reported. We estimated the impact velocity by comparing the questioned bullet with a set of comparison bullets hitting a wall (rigid target) with different velocities. The shooting distance was recovered from the impact velocity by studying the typical behavior of a manufactured 9 mm bullet weighting 115g (7.45g), shot in pistol or a sub-machine gun. The results demonstrated that the questioned bullet was a lost bullet. The shooting distance also helped the investigators, narrowing the range of the estimated positions of the shooter.

  2. Track chambers based on precision drift tubes housed inside 30 mm mylar pipe

    NASA Astrophysics Data System (ADS)

    Borisov, A.; Bozhko, N.; Fakhrutdinov, R.; Kozhin, A.; Leontiev, B.; Levin, A.

    2014-06-01

    We describe drift chambers consisting of 3 layers of 30 mm (OD) drift tubes made of double sided aluminized mylar film with thickness 0.125 mm. A single drift tube is self-supported structure withstanding 350 g tension of 50 microns sense wire located in the tube center with 10 microns precision with respect to end-plug outer surface. Such tubes allow to create drift chambers with small amount of material, construction of such chambers doesn't require hard frames. Twenty six chambers with working area from 0.8 × 1.0 to 2.5 × 2.0 m2 including 4440 tubes have been manufactured for experiments at 70-GeV proton accelerator at IHEP(Protvino).

  3. Method for producing La/Ce/MM/Y base alloys, resulting alloys and battery electrodes

    SciTech Connect

    Gschneidner, Jr., Karl A.; Schmidt, Frederick A.

    2016-12-20

    A carbothermic reduction method is provided for reducing a La-, Ce-, MM-, and/or Y-containing oxide in the presence of carbon and a source of a reactant element comprising Si, Ge, Sn, Pb, As, Sb, Bi, and/or P to form an intermediate alloy material including a majority of La, Ce, MM, and/or Y and a minor amount of the reactant element. The intermediate material is useful as a master alloy for in making negative electrode materials for a metal hydride battery, as hydrogen storage alloys, as master alloy additive for addition to a melt of commercial Mg and Al alloys, steels, cast irons, and superalloys; or in reducing Sm.sub.2O.sub.3 to Sm metal for use in Sm--Co permanent magnets.

  4. An 8-mm diameter fibre robot positioner for massive spectroscopy surveys

    NASA Astrophysics Data System (ADS)

    Fahim, N.; Prada, F.; Kneib, J. P.; Glez-de-Rivera, G.; Hörler, P.; Sánchez, J.; Azzaro, M.; Becerril, S.; Bleuler, H.; Bouri, M.; Castaño, J.; Garrido, J.; Gillet, D.; Gómez, C.; Gómez, M. A.; González-Arroyo, A.; Jenni, L.; Makarem, L.; Yepes, G.; Arrillaga, X.; Carrera, M. A.; Diego, R.; Charif, M.; Hug, M.; Lachat, C.

    2015-06-01

    Massive spectroscopic survey are becoming trendy in astrophysics and cosmology, as they can address new fundamental knowledge such as understanding the formation of the Milky Way and probing the nature of the mysterious dark energy. To enable massive spectroscopic surveys, new technology has been developed to place thousands of optical fibres at a given position on a focal plane. This technology needs to be: (1) accurate, with micrometer positional accuracy; (2) fast to minimize overhead; (3) robust to minimize failure; and (4) low cost. In this paper, we present the development, properties, and performance of a new single 8-mm in diameter fibre positioner robot, using two 4-mm DC-brushless gearmotors, that allows us to achieve accuracies up to 0.07 arcsec (5 μm). This device has been developed in the context of the Dark Energy Spectroscopic Instrument.1

  5. Pencil-like mm-size electron beams produced with linear inductive voltage adders (LIVA)

    SciTech Connect

    Mazarakis, M.G.; Poukey, J.W.; Rovang, D.C.

    1996-09-01

    This paper presents design, analysis, and first results of the high brightness electron beam experiments currently under investigation at Sandia. Anticipated beam parameters are: energy 12 MeV, current 35-40 kA, rms radius 0.5 mm, pulse duration 40 ns FWHM. The accelerator is SABRE, a pulsed LIVA modified to higher impedance, and the electron source is a magnetically immersed foilless electron diode. 20 to 30 Tesla solenoidal magnets are required to insulate the diode and contain the beam to its extremely small sized (1 mm) envelope. These experiments are designed to push the technology to produce the highest possible electron current in a submillimeter radius beam. Design, numercial simulations, and first experimental results are presented.

  6. Sub-mm functional decoupling of electrocortical signals through closed-loop BMI learning.

    PubMed

    Ledochowitsch, P; Koralek, A C; Moses, D; Carmena, J M; Maharbiz, M M

    2013-01-01

    Volitional control of neural activity lies at the heart of the Brain-Machine Interface (BMI) paradigm. In this work we investigated if subdural field potentials recorded by electrodes < 1mm apart can be decoupled through closed-loop BMI learning. To this end, we fabricated custom, flexible microelectrode arrays with 200 µm electrode pitch and increased the effective electrode area by electrodeposition of platinum black to reduce thermal noise. We have chronically implanted these arrays subdurally over primary motor cortex (M1) of 5 male Long-Evans Rats and monitored the electrochemical electrode impedance in vivo to assess the stability of these neural interfaces. We successfully trained the rodents to perform a one-dimensional center-out task using closed-loop brain control to adjust the pitch of an auditory cursor by differentially modulating high gamma (70-110 Hz) power on pairs of surface microelectrodes that were separated by less than 1 mm.

  7. Survival and photoreactivability of ultraviolet-irradiated cultured fish cells (CAF-MM1)

    SciTech Connect

    Mano, Y.; Mitani, H.; Etoh, H.; Egami, N.

    1980-12-01

    The sensitivity to ultraviolet light (uv) and photoreactivating ability of cultured fish clone cells (CAF-MM1) were investigated. Dose-survival relationship curves were obtained using the colony-forming technique at various postirradiation temperatures (33, 26, and 20/sup 0/C). At 26/sup 0/C the values of D/sub 0/, D/sub q/, and the extrapolation number (n) were 1.74 J/m/sup 2/, 2.62 J/m/sup 2/, and 4.5, respectively; no marked differences in these values were found among different temperatures. Visible light illumination after uv irradiation produced a marked increase in survival. No photoreactivation effects were observed beyond about 30 h. Caffeine increased uv sensitivity of the CAF-MM1 cells, and from the results it is suggested that the cells have some caffeine-sensitive dark repair mechanisms.

  8. High- and Mid-temperature Superconducting Sensors for Far IR/Sub-mm Applications in Space

    NASA Technical Reports Server (NTRS)

    Lakew, Brook; Brasunas, J. C.

    2004-01-01

    In this review paper an overview of the potential applications of high Tc (approx. 90 K) superconductors (HTS) and mid-Tc (approx. 39 K) superconductors (MTS) thin films in far IR/Sub-mm thermal detectors is presented. HTSs (YBCO, GdBCO etc.) were discovered in the late 80s while superconductivity in MgB2, an MTS, was discovered in 2001. The sharp transition in transport properties of HTS has allowed the fabrication of composite infrared thermal detectors (bolometers) with better figures of merit than thermopile detectors - thermopiles are currently on board the CIRS instrument on the Cassini mission to Saturn. The potential for developing even more sensitive sensors for IR/Sub-mm applications using MgB2 thin films is assessed. Current MgB2 thin film deposition techniques and film quality are reviewed.

  9. Radical quenching by rosmarinic acid from Lavandula vera MM cell culture.

    PubMed

    Kovacheva, Elena; Georgiev, Milen; Pashova, Svetlana; Angelova, Maria; Ilieva, Mladenka

    2006-01-01

    This study was conducted to evaluate the radical scavenging capacities of extracts and preparations from a Lavandula vera MM plant cell culture with different rosmarinic acid content and to compare them with pure rosmarinic and caffeic acids as well. The methods, which were used are superoxide anion and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radicals scavenging assays. Results showed that extracts and preparations from Lavandula vera MM possess strong radical scavengers, as the best both radical scavengers appeared to be the fractions with enriched rosmarinic acid content, obtained after ethylacetate fractioning (47.7% inhibition of superoxide radicals and 14.2 microM 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid equivalents, respectively). These data reveal the possibilities for application of these preparations as antioxidants.

  10. A 2.5-mm diameter probe for photoacoustic and ultrasonic endoscopy

    PubMed Central

    Yang, Joon-Mo; Chen, Ruimin; Favazza, Christopher; Yao, Junjie; Li, Chiye; Hu, Zhilin; Zhou, Qifa; Shung, K. Kirk; Wang, Lihong V.

    2012-01-01

    We have created a 2.5-mm outer diameter integrated photo-acoustic and ultrasonic mini-probe which can be inserted into a standard video endoscope’s instrument channel. A small-diameter focused ultrasonic transducer made of PMN-PT provides adequate signal sensitivity, and enables miniaturization of the probe. Additionally, this new endoscopic probe utilizes the same scanning mirror and micromotor-based built-in actuator described in our previous reports; however, the length of the rigid distal section of the new probe has been further reduced to ~35 mm. This paper describes the technical details of the mini-probe and presents experimental results that both quantify the imaging performance and demonstrate its in vivo imaging capability, which suggests that it could work as a mini-probe for certain clinical applications. PMID:23188360

  11. [Naturheilkunde und Komplementärmedizin in medizinischen Leitlinien - können europäische Normen Leitlinien für Naturheilkunde und Komplementärmedizin verdrängen?].

    PubMed

    Jütte, Robert

    2016-01-01

    Leitlinien machen in der Komplementärmedizin, wie das Beispiel der Naturheilkunde zeigt, durchaus Sinn. Sie ergänzen zum Wohle des Patienten und zur besseren Orientierung des Therapeuten die bislang, auch auf europäischer Ebene, bereits bestehenden Leitlinien, die ständig weiterentwickelt werden. Diese Ergänzung ist dringend notwendig, weil die meisten der vorliegenden Leitlinien einzelner Fachgesellschaften die Forschungsergebnisse der Komplementärmedizin, die zum Teil beachtlich und auch evidenzbasiert sind, zum Nachteil des Patienten ignorieren. Es ist bedauerlich, dass einige Richtungen der Komplementärmedizin jedoch meinen, dass eine europäische Norm, wie sie beispielsweise Osteopathen und Homöopathen mithilfe des europäischen Normungsinstituts (CEN) durchzusetzen hoffen, sie in ihrem Kampf um Anerkennung weiterbringen wird. Der Patient, der auf eine individuelle und bestmögliche Behandlung wert legt, wird jedenfalls davon nicht profitieren.

  12. Estimating the magnus moment effect on stability of 30-mm boomed projectiles

    NASA Astrophysics Data System (ADS)

    Byers, R. H.; Cobb, K.

    1985-08-01

    This report documents the results obtained from a comparison of free-flight spark range tests and PRODASMAGNUS computer stability results for 30mm spin stabilized projectiles. Two configurations were considered, each with the same boom diameter of 0.5, 1.0 inch and 1.25 inch boom lengths. The results show that PRODASMAGNUS can accurately predict the effects of a boom's presence on projectile stability.

  13. 4. East portal of Tunnel 18, view to southsoutheast, 210mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. East portal of Tunnel 18, view to south-southeast, 210mm lens. Compare the condition of the concrete at this portal, located some 350 feet lower than the west portal and on the sheltered north side of the pass, with that of the west portal in photo 1. - Southern Pacific Railroad Natron Cutoff, Tunnel 3, Milepost 537.77, Odell Lake, Klamath County, OR

  14. Charge-dependent many-body exchange and dispersion interactions in combined QM/MM simulations

    NASA Astrophysics Data System (ADS)

    Kuechler, Erich R.; Giese, Timothy J.; York, Darrin M.

    2015-12-01

    Accurate modeling of the molecular environment is critical in condensed phase simulations of chemical reactions. Conventional quantum mechanical/molecular mechanical (QM/MM) simulations traditionally model non-electrostatic non-bonded interactions through an empirical Lennard-Jones (LJ) potential which, in violation of intuitive chemical principles, is bereft of any explicit coupling to an atom's local electronic structure. This oversight results in a model whereby short-ranged exchange-repulsion and long-ranged dispersion interactions are invariant to changes in the local atomic charge, leading to accuracy limitations for chemical reactions where significant atomic charge transfer can occur along the reaction coordinate. The present work presents a variational, charge-dependent exchange-repulsion and dispersion model, referred to as the charge-dependent exchange and dispersion (QXD) model, for hybrid QM/MM simulations. Analytic expressions for the energy and gradients are provided, as well as a description of the integration of the model into existing QM/MM frameworks, allowing QXD to replace traditional LJ interactions in simulations of reactive condensed phase systems. After initial validation against QM data, the method is demonstrated by capturing the solvation free energies of a series of small, chlorine-containing compounds that have varying charge on the chlorine atom. The model is further tested on the SN2 attack of a chloride anion on methylchloride. Results suggest that the QXD model, unlike the traditional LJ model, is able to simultaneously obtain accurate solvation free energies for a range of compounds while at the same time closely reproducing the experimental reaction free energy barrier. The QXD interaction model allows explicit coupling of atomic charge with many-body exchange and dispersion interactions that are related to atomic size and provides a more accurate and robust representation of non-electrostatic non-bonded QM/MM interactions.

  15. Asymmetric Multilevel Outphasing (AMO): A New Architecture for All-Silicon mm-Wave Transmitter ICs

    DTIC Science & Technology

    2015-06-12

    AMO ) architecture and also nonlinear predistortion of the transmitter. Finally, the foundation of the entire system 1. REPORT DATE (DD-MM-YYYY) 4...2015 1-Jun-2010 29-Feb-2016 Approved for Public Release; Distribution Unlimited Final Report: Asymmetric Multilevel Outphasing ( AMO ): A New Architecture...journals: Number of Papers published in non peer-reviewed journals: Final Report: Asymmetric Multilevel Outphasing ( AMO ): A New Architecture for All

  16. STS-30 Pilot Grabe uses 35mm camera on aft flight deck

    NASA Technical Reports Server (NTRS)

    1989-01-01

    STS-30 Pilot Ronald J. Grabe, positioned at aft flight deck overhead window W7, holds 35mm camera before photographing Earth observation scene visible outside window. Appearing around Grabe are a pair of binoculars (freefloating in overhead window), overhead light fixture, onorbit station control panels, and a communications kit assembly headset interface unit (HIU) velcroed to onorbit station panel. Grabe is wearing mission polo shirt and light blue flight coverall pants.

  17. Magnetic field measurements of full length 50 mm aperture SSC dipole magnets at Fermilab

    SciTech Connect

    Strait, J.; Bossert, R.; Carson, J.; Delchamps, S.W.; Gourlay, S.; Hanft, R.; Koska, W.; Kuchnir, M.; Lamm, M.J.; Mazur, P.O.; Mokhtarani, A.; Orris, D.; Ozelis, J.; Wake, M. ); Devred, A.; DiMarco, J.; Kuzminski, J.; Puglisi, M.; Tompkins, J.C.; Yu, Y.; Zhao, Y.; Zheng, H. ); Ogitsu, T. (Supe

    1992-09-01

    Thirteen 16 m long, 50 mm aperture SSC dipole magnets, designed jointly by Fermilab, Brookhaven National Laboratory, Lawrence Berkeley Laboratory and the SSC Laboratory, have been built at Fermilab. The first nine magnets have been fully tested to date. The allowed harmonics are systematically shifted from zero by amounts larger than the specification. The unallowed harmonics, with the exception of the skew sextupole, are consistent with zero. The magnet-to-magnet RMS variation of all harmonics is much smaller than the specification.

  18. AzTEC 1.1 mm OBSERVATIONS OF THE MBM12 MOLECULAR CLOUD

    SciTech Connect

    Kim, M. J.; Kim, S.; Youn, S.; Kang, Y.-W.; Yun, M. S.; Wilson, G. W.; Aretxaga, I.; Hughes, D. H.; Humphrey, A.; Williams, J. P.; Austermann, J. E.; Perera, T. A.; Mauskopf, P. D.; Magnani, L.

    2012-02-10

    We present 1.1 mm observations of the dust continuum emission from the MBM12 high-latitude molecular cloud observed with the Astronomical Thermal Emission Camera (AzTEC) mounted on the James Clerk Maxwell Telescope on Mauna Kea, Hawaii. We surveyed 6.34 deg{sup 2} centered on MBM12, making this the largest area that has ever been surveyed in this region with submillimeter and millimeter telescopes. Eight secure individual sources were detected with a signal-to-noise ratio of over 4.4. These eight AzTEC sources can be considered to be real astronomical objects compared to the other candidates based on calculations of the false detection rate. The distribution of the detected 1.1 mm sources or compact 1.1 mm peaks is spatially anti-correlated with that of the 100 {mu}m emission and the {sup 12}CO emission. We detected the 1.1 mm dust continuum emitting sources associated with two classical T Tauri stars, LkH{alpha}262 and LkH{alpha}264. Observations of spectral energy distributions (SEDs) indicate that LkH{alpha}262 is likely to be Class II (pre-main-sequence star), but there are also indications that it could be a late Class I (protostar). A flared disk and a bipolar cavity in the models of Class I sources lead to more complicated SEDs. From the present AzTEC observations of the MBM12 region, it appears that other sources detected with AzTEC are likely to be extragalactic and located behind MBM12. Some of these have radio counterparts and their star formation rates are derived from a fit of the SEDs to the photometric evolution of galaxies in which the effects of a dusty interstellar medium have been included.

  19. Charge-dependent many-body exchange and dispersion interactions in combined QM/MM simulations

    SciTech Connect

    Kuechler, Erich R.; Giese, Timothy J.; York, Darrin M.

    2015-12-21

    Accurate modeling of the molecular environment is critical in condensed phase simulations of chemical reactions. Conventional quantum mechanical/molecular mechanical (QM/MM) simulations traditionally model non-electrostatic non-bonded interactions through an empirical Lennard-Jones (LJ) potential which, in violation of intuitive chemical principles, is bereft of any explicit coupling to an atom’s local electronic structure. This oversight results in a model whereby short-ranged exchange-repulsion and long-ranged dispersion interactions are invariant to changes in the local atomic charge, leading to accuracy limitations for chemical reactions where significant atomic charge transfer can occur along the reaction coordinate. The present work presents a variational, charge-dependent exchange-repulsion and dispersion model, referred to as the charge-dependent exchange and dispersion (QXD) model, for hybrid QM/MM simulations. Analytic expressions for the energy and gradients are provided, as well as a description of the integration of the model into existing QM/MM frameworks, allowing QXD to replace traditional LJ interactions in simulations of reactive condensed phase systems. After initial validation against QM data, the method is demonstrated by capturing the solvation free energies of a series of small, chlorine-containing compounds that have varying charge on the chlorine atom. The model is further tested on the S{sub N}2 attack of a chloride anion on methylchloride. Results suggest that the QXD model, unlike the traditional LJ model, is able to simultaneously obtain accurate solvation free energies for a range of compounds while at the same time closely reproducing the experimental reaction free energy barrier. The QXD interaction model allows explicit coupling of atomic charge with many-body exchange and dispersion interactions that are related to atomic size and provides a more accurate and robust representation of non-electrostatic non-bonded QM/MM

  20. Analysis of Proposed Solutions to the 5.56mm Blank Cartridge (M200) Malfunction Rate

    DTIC Science & Technology

    1976-01-01

    TO THE 5 . 56MM BLANK CARTRIDGE (M200 ) MALFUNCTION RATE. — 8 - TITLE CLASSIFICATION: UNCLASSIFIED — 9 - DESCRIPTIVE NOTE: FINAL NOTE, —10...REGION DOES NOT ALWAYS STACK AS SHOWN by Rock Island in Sept 1975. The tested items consisted of 3 weapons (produced by Colt), 300 rounds of M200 blank...round (stubs were not recorded). Therefore, the testing of the 20-round magazine with that weapon was discontinued. Three 30- round magazines were

  1. Prototyping 9-inch size PSM mask blanks for 450mm wafer process (2016)

    NASA Astrophysics Data System (ADS)

    Harashima, Noriyuki; Iso, Hiroyuki; Chishima, Tatsuya

    2016-10-01

    6-inch size (known as 6025QZ) binary Cr mask is widely used in the semiconductor lithography for over 20years. Recently for the 450mm wafer process, high grade 9-inch size mask is expected. For this application, we have studied and developed prototyping 9-inch size PSM KrF and ArF mask blanks. This time we will explain these PSM mask blanks status.

  2. A QM/MM study of absorption spectra of uracil derivatives in aqueous solution

    NASA Astrophysics Data System (ADS)

    Nakayama, Akira

    2016-12-01

    The absorption spectra of three representative uracil derivatives (uracil, thymine, and 5-fluorouracil) in aqueous solution are investigated by the QM/MM approach, where the CASPT2 method is employed to evaluate the excitation energies. The computed absorption spectra are in good agreement with the experimental results, and in particular, the relative values of the absorption maximum between these derivatives are well reproduced in the simulations.

  3. (Manufacturing of the 40/30 mm gated image intensifier tube)

    SciTech Connect

    Vine, B.H.

    1990-04-27

    One of EG G's customers is attempting to find a manufacturer to make the 40/30 mm gated image intensifier tube. A request for quotation had been sent out to a number of manufacturers. The tube performance required was not fully defined and the replies, as expected, came back with caveats to cover the areas of uncertainty. The trip was undertaken to discuss the project, to more clearly define the areas of uncertainty and to evaluate the capabilities of the manufacturers.

  4. 1.1 mm Observations of the MBM12 Molecular Cloud

    NASA Astrophysics Data System (ADS)

    Kim, Sungeun; Kim, M.; Youn, S.; Yun, M. S.; Wilson, G. W.; Aretxaga, I.; Williams, J. P.; Hughes, D. H.; Humphrey, A.; Austermann, J. E.; Perera, T. A.; Mauskopf, P. D.; Magnani, L.

    2012-05-01

    We present 1.1 mm observations of the dust continuum emission from the MBM12 high-latitude molecular cloud observed with the Astronomical Thermal Emission Camera (AzTEC) mounted on the James Clerk Maxwell Telescope (JCMT) on Mauna Kea, Hawaii. Eight secure individual sources were detected with over 4.4 signal-to-noise ratio. These eight AzTEC sources can be considered to be real astronomical objects compared to the other candidates based on calculations of the false detection rate (FDR). The distribution of the detected 1.1 mm sources or compact 1.1 mm peaks is spatially anti-correlated with that of the 100 microm emission and the CO emission. We detected the 1.1 mm dust continuum emitting sources associated with two classical T Tauri stars, LkHalpha 262 and LkHalpha 264. Observations of spectral energy distributions (SEDs) indicate that LkHalpha 262 is likely to be Class II (pre-main sequence star), but there are also indications that it could be a late Class I (protostar). A flared disk and a bipolar cavity in the models of Class I sources lead to more complicated SEDs. From the present AzTEC observations of the MBM12 region, it appears that other sources detected with AzTEC are likely to be extragalactic and located behind MBM12. Some of these have radio counterparts and their star-formation rates (SFRs) are derived from a fit of the SEDs to the photometric evolution of galaxies in which the effects of a dusty interstellar medium have been included. This research was supported in part by Mid-career Researcher Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology 2011-0028001.

  5. A wind-driving disc model for the mm-wavelength polarization structure of HL Tau

    NASA Astrophysics Data System (ADS)

    Matsakos, Titos; Tzeferacos, Petros; Königl, Arieh

    2016-12-01

    The recent advent of spatially resolved mm- and cm-wavelength polarimetry in protostellar accretion discs could help clarify the role of magnetic fields in the angular momentum transport in these systems. The best case to date is that of HL Tau, where the inability to produce a good fit to the 1.25-mm data with a combination of vertical and azimuthal magnetic field components was interpreted as implying that centrifugally driven winds (CDWs) are probably not a significant transport mechanism on the ˜102 au scale probed by the observations. Using synthetic polarization maps of heuristic single-field-component discs and of a post-processed simulation of a wind-driving disc, we demonstrate that a much better fit to the data can be obtained if the radial field component, a hallmark of the CDW mechanism, dominates in the polarized emission region. A similar inference was previously made in modelling the far-infrared polarization map of the pc-scale dust ring in the Galactic Centre. To reconcile this interpretation with theoretical models of protostellar discs, which indicate that the wind is launched from a comparatively high elevation above the mid-plane, we propose that most of the polarized emission originates - with a high ( ≳ 10 per cent) intrinsic degree of polarization - in small ( ≲ 0.1 mm) grains that remain suspended above the mid-plane, and that the bulk of the mm-wavelength emission is produced - with low intrinsic polarization - by larger grains that have settled to the mid-plane.

  6. 1. West portal of Tunnel 36, view to northeast, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. West portal of Tunnel 36, view to northeast, 135mm lens. Note the notched wingwalls that originally held timber posts of the original timber snowsheds, miles of which once enclosed and protected the railroad from the ravages of Sierra winters. Note also that these tunnels, built in the 1920s, have dispensed with any use of stone masonry, and instead have all-concrete portals. - Central Pacific Transcontinental Railroad, Tunnel No. 36, Milepost 176.92, Yuba Pass, Nevada County, CA

  7. Rapid biodegradation of polycyclic aromatic hydrocarbons (PAHs) using effective Cronobacter sakazakii MM045 (KT933253).

    PubMed

    Umar, Zubairu Darma; Aziz, Nor Azwady Abd; Zulkifli, Syaizwan Zahmir; Mustafa, Muskhazli

    2017-01-01

    Polycyclic Aromatic Hydrocarbons (PAHs) are complex and widely distributed environmental pollutants that can affect living ecosystems. This study was conducted to rapidly degrade phenanthrene and pyrene representing low and high molecular weight of PAHs, respectively. Cronobacter sakazakii MM045 (KT933253) was identified from used engine oil of contaminated soil. PAHs biodegradation was carried out using 2,6-dichlorophenol indophenol (DCPIP) assay. Biodegradation influencing factors including agitation, temperature, pH, inoculums volume and salinity were enhanced using Response Surface Methodology (RSM) by Central Composite Design (CCD). Phenanthrene and pyrene biodegrading metabolites were identified using gas chromatography mass spectrophotometer (GCMS). •Initial biodegradation indicated 75.2% and 54.3% phenanthrene and pyrene degraded by C. sakazakii MM045 within 24 h. After CCD optimisation, 100% degradation was achieved for each of the phenanthrene and pyrene, resulting in the formation of intermediate metabolites.•The identified phenanthrene metabolites were 3,4-dihydroxyphenathrene, phthalic acid, pyruvic acid, acetic acid and oxalic acid. Pyrene intermediates comprised pyrene cis-4,5-dihydrodiol, 3,4-dihydroxyphenanthrene, phthalic acid, pyruvic acid, acetic acid and lactic acid.•Cronbacter sakazakii MM045 was proven to be rapid and effective in degrading PAHs within 24 h despite the unavailability of existing literatures on PAHs biodegradation.

  8. [An 18 month evaluation of MM-MTA pulpotomy on primary decayed molars].

    PubMed

    Abou Chedid, J C; Mchayleh, N; Khalil, I; Melki, B; Hardan, L S

    2015-12-01

    Pulpotomy is the most performed and controversial therapeutic in pediatric dentistry. Formocresol is known to have a toxic effect on living tissues, a mutagenic and carcinogenic potential with a systemic uptake of formocresol via pulpotomized teeth, other alternative products have been investigated. 40 molars were pulpotomized using Micro Mega Mineral Trioxide Aggregate (MM-MTA), which eliminates the need for the use of formocresol. The effects of this material were evaluated both clinically and radiographically. Post-operative control examinations were performed at 1, 6, 12, and 18 months trying to detect spontaneous or stimulated pain, pathological tooth mobility, abscesses or fistulas, internal or external pathological tooth resorption, periapical bone destruction, or canal obliteration. Pain was absent at 18 months post operatively. Thirty six molar treated with the MM-MTA didn't show any mobility or pain, one molar presented a pathological resorption and one molar presented an abscess without a fistula at 12 month. The observations were compared to others related to formocresol, ferric sulfate, MTA, and laser pulpotomies, using the Chi-square test x2. The abundance of positive result strongly demonstrate that the MM-MTA pulpotomy on carious temporary molars is a promising technique.

  9. Quantum supercharger library: hyper-parallel integral derivatives algorithms for ab initio QM/MM dynamics.

    PubMed

    Renison, C Alicia; Fernandes, Kyle D; Naidoo, Kevin J

    2015-07-05

    This article describes an extension of the quantum supercharger library (QSL) to perform quantum mechanical (QM) gradient and optimization calculations as well as hybrid QM and molecular mechanical (QM/MM) molecular dynamics simulations. The integral derivatives are, after the two-electron integrals, the most computationally expensive part of the aforementioned calculations/simulations. Algorithms are presented for accelerating the one- and two-electron integral derivatives on a graphical processing unit (GPU). It is shown that a Hartree-Fock ab initio gradient calculation is up to 9.3X faster on a single GPU compared with a single central processing unit running an optimized serial version of GAMESS-UK, which uses the efficient Schlegel method for s- and l-orbitals. Benchmark QM and QM/MM molecular dynamics simulations are performed on cellobiose in vacuo and in a 39 Å water sphere (45 QM atoms and 24843 point charges, respectively) using the 6-31G basis set. The QSL can perform 9.7 ps/day of ab initio QM dynamics and 6.4 ps/day of QM/MM dynamics on a single GPU in full double precision. © 2015 Wiley Periodicals, Inc.

  10. SXDF-ALMA 2-arcmin2 deep survey: 1.1-mm number counts

    NASA Astrophysics Data System (ADS)

    Hatsukade, Bunyo; Kohno, Kotaro; Umehata, Hideki; Aretxaga, Itziar; Caputi, Karina I.; Dunlop, James S.; Ikarashi, Soh; Iono, Daisuke; Ivison, Rob J.; Lee, Minju; Makiya, Ryu; Matsuda, Yuichi; Motohara, Kentaro; Nakanishi, Kouichiro; Ohta, Kouji; Tadaki, Ken-ich; Tamura, Yoichi; Wang, Wei-Hao; Wilson, Grant W.; Yamaguchi, Yuki; Yun, Min S.

    2016-06-01

    We report 1.1-mm number counts revealed with the Atacama Large Millimeter/submillimeter Array (ALMA) in the Subaru/XMM-Newton Deep Survey Field (SXDF). The advent of ALMA enables us to reveal millimeter-wavelength number counts down to the faint end without source confusion. However, previous studies are based on the ensemble of serendipitously detected sources in fields originally targeting different sources and could be biased due to the clustering of sources around the targets. We derive number counts in the flux range of 0.2-2 mJy by using 23 (≥4σ) sources detected in a continuous 2.0-arcmin2 area of the SXDF. The number counts are consistent with previous results within errors, suggesting that the counts derived from serendipitously detected sources are not significantly biased, although there could be field-to-field variation due to the small survey area. By using the best-fitting function of the number counts, we find that ˜40% of the extragalactic background light at 1.1 mm is resolved at S1.1mm > 0.2 mJy.

  11. Results of Endovascular Coil Embolization Treatment for Small (≤ 5 mm) Unruptured Intracranial Aneurysms

    PubMed Central

    Lee, Siwoo; Lee, Yong-Woo; Kim, Hyo-Joon; Kweon, Chang-young

    2016-01-01

    Objective Researchers and clinicians have been unable to fully elucidate the natural course of and proper treatment for unruptured intracranial aneurysms (UIAs) smaller than or equal to 5 mm, particularly with regard to whether close observation or surgery is more appropriate. In this retrospective study, we evaluated the safety and efficacy of endovascular coil embolization of small (≤ 5 mm) asymptomatic UIAs by analyzing outcomes and complications associated with the procedure. Materials and Methods We analyzed data from 150 patients with small asymptomatic UIAs (≤ 5 mm) treated with coil embolization between January 2011 and December 2015. Three-dimensional angiography was used to measure aneurysm size. We evaluated procedure-related morbidity and mortality, immediate post-operative angiographic results, brain computed thomography follow-up results on post-operative day one, and clinical progress. Results UIAs occurred primarily in the anterior circulation area (142 cases, 94.67%), though eight patients exhibited UIAs of the posterior circulation. Following coil embolization, aneurysms with complete occlusion were observed in 137 cases (91.3%). Partial occlusion occurred in five cases (3.33%), while the procedure had failed in eight cases (5.33%). Procedure-related morbidity and mortality were five cases (3.33%) and zero cases, respectively. Conclusion The endovascular treatment of small asymptomatic UIAs is associated with good short-term outcomes without permanent neurologic complications as well as low overall complication and morbidity rates. Thus, the procedure should be considered for patients with smaller asymptomatic UIAs. PMID:27847766

  12. QM/MM Analysis of Cellulase Active Sites and Actions of the Enzymes on Substrates

    SciTech Connect

    Saharay, Moumita; Guo, Hao-Bo; Smith, Jeremy C; Guo, Hong

    2010-01-01

    Biodegradation of cellulosic biomass requires the actions of three types of secreted enzymes; endoglucanase (EC 3.2.1.4), cellobiohydrolase or exoglucanase (EC 3.2.1.91), and -glucosidase (EC 4.2.1.21). These enzymes act synergistically to hydrolyse the -1,4 bonds of cellulose and converts it into simple sugar. Hydrolysis of the glycosidic bond can occur either by net retention or by inversion of anomeric configuration at the anomeric center. QM/MM simulations are useful tools to study the energetics of the reactions and analyze the active-site structures at different states of the catalysis, including the formation of unstable transition states. Here, a brief description of previous work on glycoside hydrolases is first given. The results of the QM/MM potential energy and free energy simulations corresponding to glycosylation and deglycosylation processes are then provided for two retaining endoglucanases, Cel12A and Cel5A. The active-site structural features are analyzed based on the QM/MM results. The role of different residues and hydrogen bonding interactions during the catalysis and the importance of the sugar ring distortion are discussed for these two enzymes.

  13. Temporal arteritis with erythrocyte sedimentation rate <50 mm/h: a clinical reminder

    PubMed Central

    Cheema, Muhammad Raza; Ismaeel, Shakawan M

    2016-01-01

    Temporal arteritis, also known as giant cell arteritis (GCA), is a systemic vasculitis that predominantly involves the temporal arteries. It is a medical emergency and should be treated promptly as it can lead to permanent loss of vision. It is very commonly associated with a raised erythrocyte sedimentation rate (ESR), usually >50 mm/h, one of the essential criteria defined by the American College of Rheumatology classification of GCA. Here, we describe the case of a 73-year-old male presenting with a 2-day history of a sudden onset of a severe left-sided headache, which had the signs and symptoms consistent with GCA but he had an ESR of only 27 mm/h. The patient was urgently treated with prednisolone 60 mg per day, and his symptoms dramatically improved within 24 hours of therapy. Temporal artery biopsy results were consistent with an inflammatory response, and withdrawal of treatment led to a relapse of the symptoms. The patient was slowly tapered off the high steroid dose and is now currently managed on a low steroid dose. We should keep a high index of suspicion for GCA in patients presenting with clinical symptoms of GCA even though the ESR is <50 mm/h as stated in the criteria for GCA diagnosis. PMID:26966355

  14. Fast polarization changes in mm microwave emission of weak multistructured solar bursts

    NASA Technical Reports Server (NTRS)

    Kaufmann, P.; Strauss, F. M.; Costa, J. E. R.; Dennis, B. R.

    1982-01-01

    Circular polarization of weak multistructured solar bursts was measured at mm microwaves with unprecedented sensitivity (0.03 sfu rms) and high time resolution (1ms). It was shown that sudden changes occur in the degree of polarization with time scales of 0.04 to 0.3 s. In most cases the degree of polarization attained maximum values before the maximum flux in both mm microwaves and hard X-rays with time scales of 0.04 to 1.0 s. The timing accuracy in determining the degree of polarization was 40 ms. Physical phenomena are discussed invoking one or a combination of various possible causes for the observed effects. The bursts at mm microwaves were weak compared to the contribution of the preexisting active regions, and therefore the changes in magnetoionic propagation conditions for emerging radiation plays an important role in the observed effects. Composite effects due to more than one polarizing mechanism or more than one polarized spots within the antenna beam are discussed.

  15. New long-zoom lens for 4K super 35mm digital cameras

    NASA Astrophysics Data System (ADS)

    Thorpe, Laurence J.; Usui, Fumiaki; Kamata, Ryuhei

    2015-05-01

    The world of television production is beginning to adopt 4K Super 35 mm (S35) image capture for a widening range of program genres that seek both the unique imaging properties of that large image format and the protection of their program assets in a world anticipating future 4K services. Documentary and natural history production in particular are transitioning to this form of production. The nature of their shooting demands long zoom lenses. In their traditional world of 2/3-inch digital HDTV cameras they have a broad choice in portable lenses - with zoom ranges as high as 40:1. In the world of Super 35mm the longest zoom lens is limited to 12:1 offering a telephoto of 400mm. Canon was requested to consider a significantly longer focal range lens while severely curtailing its size and weight. Extensive computer simulation explored countless combinations of optical and optomechanical systems in a quest to ensure that all operational requests and full 4K performance could be met. The final lens design is anticipated to have applications beyond entertainment production, including a variety of security systems.

  16. Computing kinetic isotope effects for chorismate mutase with high accuracy. A new DFT/MM strategy.

    PubMed

    Martí, Sergio; Moliner, Vicent; Tuñón, Iñaki; Williams, Ian H

    2005-03-10

    A novel procedure has been applied to compute experimentally unobserved intrinsic kinetic isotope effects upon the rearrangement of chorismate to prephenate catalyzed by B. subtilis chorismate mutase. In this modified QM/MM approach, the "low-level" QM description of the quantum region is corrected during the optimization procedure by means of a "high-level" calculation in vacuo, keeping the QM-MM interaction contribution at a quantum "low-level". This allows computation of energies, gradients, and Hessians including the polarization of the QM subsystem and its interaction with the MM environment, both terms calculated using the low-level method at a reasonable computational cost. New information on an important enzymatic transformation is provided with greater reliability than has previously been possible. The predicted kinetic isotope effects on Vmax/Km are 1.33 and 0.86 (at 30 degrees C) for 5-3H and 9-3H2 substitutions, respectively, and 1.011 and 1.055 (at 22 degrees C) for 1-13C and 7-18O substitutions, respectively.

  17. An extensible interface for QM/MM molecular dynamics simulations with AMBER

    PubMed Central

    Götz, Andreas W.; Clark, Matthew A.; Walker, Ross C.

    2014-01-01

    We present an extensible interface between the AMBER molecular dynamics (MD) software package and electronic structure software packages for quantum mechanical (QM) and mixed QM and classical molecular mechanical (MM) MD simulations within both mechanical and electronic embedding schemes. With this interface, ab initio wave function theory and density functional theory methods, as available in the supported electronic structure software packages, become available for QM/MM MD simulations with AMBER. The interface has been written in a modular fashion that allows straight forward extensions to support additional QM software packages and can easily be ported to other MD software. Data exchange between the MD and QM software is implemented by means of files and system calls or the message passing interface standard. Based on extensive tests, default settings for the supported QM packages are provided such that energy is conserved for typical QM/MM MD simulations in the microcanonical ensemble. Results for the free energy of binding of calcium ions to aspartate in aqueous solution comparing semiempirical and density functional Hamiltonians are shown to demonstrate features of this interface. PMID:24122798

  18. One-dimensional neutron focusing with large beam divergence by 400mm-long elliptical supermirror

    NASA Astrophysics Data System (ADS)

    Nagano, M.; Yamaga, F.; Yamazaki, D.; Maruyama, R.; Hayashida, H.; Soyama, K.; Yamamura, K.

    2012-02-01

    Reflective optics is one of the most useful techniques for focusing a neutron beam with a wide wavelength range since there is no chromatic aberration. Neutrons can be focused within a small area of less than 1 mm2 by high-performance aspherical supermirrors with high figure accuracy and a low smooth substrate surface and a multilayer interface. Increasing the mirror size is essential for increasing the focusing gain. We have developed a fabrication process that combines conventional precision grinding, HF dip etching, numerically controlled local wet etching (NC-LWE) figuring, low-pressure polishing and ion beam sputtering deposition of the supermirror coating to fabricate a large aspherical supermirror. We designed and fabricated an piano-elliptical mirror with large clear aperture size using the developed fabrication process. We obtained a figure error of 0.43 μm p-v and an rms roughness of less than 0.2 nm within an effective reflective length of 370 mm. A NiC/Ti supermirror with m = 4 was deposited on the substrate using ion beam sputtering equipment. The results of focusing experiments show that a focusing gain of 52 at the peak intensity was achieved compared with the case without focusing. Furthermore, the result of imaging plate measurements indicated that the FWHM focusing width of the fabricated mirror is 0.128 mm.

  19. Asymmetric Directional Multicast for Capillary Machine-to-Machine Using mmWave Communications.

    PubMed

    Kwon, Jung-Hyok; Kim, Eui-Jik

    2016-04-11

    The huge demand for high data rate machine-to-machine (M2M) services has led to the use of millimeter Wave (mmWave) band communications with support for a multi-Gbps data rate through the use of directional antennas. However, unnecessary sector switching in multicast transmissions with directional antennas results in a long delay, and consequently a low throughput. We propose asymmetric directional multicast (ADM) for capillary M2M to address this problem in mmWave communications. ADM provides asymmetric sectorization that is optimized for the irregular deployment pattern of mulicast group members. In ADM, an M2M gateway builds up asymmetric sectors with a beamwidth of a different size to cover all multicast group members with the minimum number of directional transmissions. The performance of ADM under various simulation environments is evaluated through a comparison with legacy mmWave multicast. The results of the simulation indicate that ADM achieves a better performance in terms of the transmission sectors, the transmission time, and the aggregate throughput when compared with the legacy multicast method.

  20. Asymmetric Directional Multicast for Capillary Machine-to-Machine Using mmWave Communications

    PubMed Central

    Kwon, Jung-Hyok; Kim, Eui-Jik

    2016-01-01

    The huge demand for high data rate machine-to-machine (M2M) services has led to the use of millimeter Wave (mmWave) band communications with support for a multi-Gbps data rate through the use of directional antennas. However, unnecessary sector switching in multicast transmissions with directional antennas results in a long delay, and consequently a low throughput. We propose asymmetric directional multicast (ADM) for capillary M2M to address this problem in mmWave communications. ADM provides asymmetric sectorization that is optimized for the irregular deployment pattern of mulicast group members. In ADM, an M2M gateway builds up asymmetric sectors with a beamwidth of a different size to cover all multicast group members with the minimum number of directional transmissions. The performance of ADM under various simulation environments is evaluated through a comparison with legacy mmWave multicast. The results of the simulation indicate that ADM achieves a better performance in terms of the transmission sectors, the transmission time, and the aggregate throughput when compared with the legacy multicast method. PMID:27077859

  1. Performance of 0. 75 mm pitch MWPC'S operating at high rate

    SciTech Connect

    Conetti, S.; Kuzminski, J.; Marchionni, A.; Stairs, D.; Arenton, M.; Chen, T.Y.; Cox, B.; Delchamps, S.; Etemadi, B.; Fortney, L.

    1989-01-01

    Three Multiwire Proportional Chambers (MWPC) with high rate capability have been constructed for Fermi National Accelerator Laboratory experiment 705 (Charmonium and Direct Photon production by ..pi../sup +-/, p and /bar p/ at 300 GeV/c). Each chamber, with a sensitive area of 308 cm/sup 2/, consists of three anode planes, wound with 12.5 ..mu..m diameter gold-plated tungsten/rhenium wire, facing 25 ..mu..m graphite-coated kapton cathode planes at a distance of 3 mm. Wire spacing in two of the MWPC (PC-B1 and PC-B2) is 0.75 mm and 1.00 mm in the third one (PC-B3). After a few weeks of running on ''Magic Gas'' with a beam flux of up to /approximately/10/sup 7/ particles/cm/sup 2/sec, severe damage occurred to the graphite coating. All cathode planes were replaced by aluminized kapton, and the chambers worked successfully for the next 3 months until the end of the run, when a 10% efficiency drop was observed after a total accumulated charge of /approximately/1 C/cm of sense wire. After the end of the run the chambers were disassembled and inspected. A white deposit with a characteristic ''wire pattern'' etched away from the Al coating was observed in the region of the beam spot. 10 refs., 8 figs., 1 tab.

  2. Clinical evaluation of a high-resolution (2. 6-mm) positron emission tomography

    SciTech Connect

    Valk, P.E.; Jagust, W.J.; Derenzo, S.E.; Huesman, R.H.; Geyer, A.B.; Budinger, T.F. )

    1990-09-01

    The intrinsic resolution of the Donner 600-crystal positron emission tomograph (PET 600) is 2.6 mm full width at half maximum (FWHM) in-plane and 6 mm FWHM axially. More than 100 patients with glioma, radiation necrosis, Alzheimer disease, or epilepsy have been studied with this system. Approximately 1 million events are acquired in 15 minutes, starting 1 hour after injection of 10 mCi (370 MBq) of fluorine-18-fluorodeoxyglucose. Normal structures as small as the superior colliculi and the external capsule have been resolved. Improved separation of the cortical ribbon from adjacent white matter has allowed more accurate determination of cortical metabolic rate. In two of 15 patients undergoing evaluation for recurrent glioma, the PET 600 images showed tumor uptake that was not apparent on a lower-resolution study. A high-activity orbiting transmission source with electronic collimation allows accurate, short-duration transmission measurements to be made after radiopharmaceutical administration. The anatomic detail seen on the transmission images can be used for reproducible patient positioning with an accuracy of 1-2 mm perpendicular to the image plane. These findings demonstrate the practicality and clinical effectiveness of high-resolution positron emission tomography.

  3. Simple Link Atom Saccharide Hybrid (SLASH) Treatment for Glycosidic Bonds at the QM/MM Boundary.

    PubMed

    Crous, Werner; Field, Martin J; Naidoo, Kevin J

    2014-04-08

    We investigated link atom approaches for treating the polar C-O bond with particular reference to the glycosidic bond found in complex carbohydrates. We show that cutting this bond after the oxygen in the QM region and saturating the QM system with a hydrogen link atom leads to greater conformational and configurational accuracy at the boundary compared with cutting the bond before oxygen and saturating the QM system with a halogen link atom to represent the oxygen. Furthermore, we find that balancing the MM atom charges and redistributing the boundary atom charges at the QM/MM boundary minimizes the effect of the link atom, both energetically and structurally. This is illustrated via a series of calculations on a set of carbohydrate and carbohydrate-like model compounds. Finally, we confirm the validity of our model by performing molecular dynamics simulations for a typical disaccharide model compound in water. Our postsimulation conformational and configurational analyses show that the oxygen-to-water hydrogen pair distribution functions and the Φ,Ψ distributions at the glycosidic boundary between the quantum and classical regions compare favorably with results obtained from complete QM and complete MM treatments of the saccharide.

  4. A system-level simulator for indoor mmW SAR imaging and its applications.

    PubMed

    Qi, Feng; Ocket, Ilja; Schreurs, Dominique; Nauwelaers, Bart

    2012-10-08

    Recently, the research interest in indoor active millimeter wave (mmW) imaging by applying the synthetic aperture radar (SAR) technique is increasing. However, there is a lack of proper computer-aided design (CAD) tools at the system level, and almost all the R&D activities rely on experiments solely. The high cost of such a system stops many researchers from investigating such a fascinating research topic. Moreover, the experiment-oriented studies may blind the researchers to some details during the imaging process, since in most cases they are only interested in the readout from the receivers and do not know how the waves perform in reality. To bridge such a gap, we propose a modeling approach at mmW frequencies, which is able to simulate the physical process during SAR imaging. We are not going to discuss about advanced image reconstruction algorithms, since they have already been investigated intensively for decades. To distinguish from previous work, for the first time, we model the data acquisition process in a SAR imaging system successfully at mmW frequencies. We show how to perform some system-level studies based on such a simulator via a common PC, including the influence of reflectivity contrast between object and background, sampling step, and antenna's directivity on image quality. The simulator can serve system design purposes and it can be easily extended to THz frequencies.

  5. The Preemptive Stocker Dispatching Rule of Automatic Material Handling System in 300 mm Semiconductor Manufacturing Factories

    NASA Astrophysics Data System (ADS)

    Wang, C. N.; Lin, H. S.; Hsu, H. P.; Wang, Yen-Hui; Chang, Y. P.

    2016-04-01

    The integrated circuit (IC) manufacturing industry is one of the biggest output industries in this century. The 300mm wafer fabs is the major fab size of this industry. The automatic material handling system (AMHS) has become one of the most concerned issues among semiconductor manufacturers. The major lot delivery of 300mm fabs is used overhead hoist transport (OHT). The traffic jams are happened frequently due to the wide variety of products and big amount of OHTs moving in the fabs. The purpose of this study is to enhance the delivery performance of automatic material handling and reduce the delay and waiting time of product transportation for both hot lots and normal lots. Therefore, this study proposes an effective OHT dispatching rule: preemptive stocker dispatching (PSD). Simulation experiments are conducted and one of the best differentiated preemptive rule, differentiated preemptive dispatching (DPD), is used for comparison. Compared with DPD, The results indicated that PSD rule can reduce average variable delivery time of normal lots by 13.15%, decreasing average variable delivery time of hot lots by 17.67%. Thus, the PSD rule can effectively reduce the delivery time and enhance productivity in 300 mm wafer fabs.

  6. An extensible interface for QM/MM molecular dynamics simulations with AMBER.

    PubMed

    Götz, Andreas W; Clark, Matthew A; Walker, Ross C

    2014-01-15

    We present an extensible interface between the AMBER molecular dynamics (MD) software package and electronic structure software packages for quantum mechanical (QM) and mixed QM and classical molecular mechanical (MM) MD simulations within both mechanical and electronic embedding schemes. With this interface, ab initio wave function theory and density functional theory methods, as available in the supported electronic structure software packages, become available for QM/MM MD simulations with AMBER. The interface has been written in a modular fashion that allows straight forward extensions to support additional QM software packages and can easily be ported to other MD software. Data exchange between the MD and QM software is implemented by means of files and system calls or the message passing interface standard. Based on extensive tests, default settings for the supported QM packages are provided such that energy is conserved for typical QM/MM MD simulations in the microcanonical ensemble. Results for the free energy of binding of calcium ions to aspartate in aqueous solution comparing semiempirical and density functional Hamiltonians are shown to demonstrate features of this interface.

  7. Design and Fabrication Highlights Enabling a 2 mm, 128 Element Bolometer Array for GISMO

    NASA Technical Reports Server (NTRS)

    Allen, Christine; Benford, Dominic; Miller, Timothy; Staguhn, Johannes; Wollack, Edward; Moseley, Harvey

    2007-01-01

    The Backshort-Under-Grid (BUG) superconducting bolometer array architecture is intended to be highly versatile, operating in a large range of wavelengths and background conditions. We have undertaken a three-year program to develop key technologies and processes required to build kilopixel arrays. To validate the basic array design and to demonstrate its applicability for future kilopixel arrays, we have chosen to demonstrate a 128 element bolometer array optimized for 2 mm wavelength using a newly built Goddard instrument, GISMO (Goddard /RAM Superconducting 2-millimeter Observer). The arrays are fabricated using batch wafer processing developed and optimized for high pixel yield, low noise, and high uniformity. The molybdenum-gold superconducting transition edge sensors are fabricated using batch sputter deposition and are patterned using dry etch techniques developed at Goddard. With a detector pitch of 2 mm 8x16 array for GISMO occupies nearly one half of the processing area of a 100 mm silicon-on-insulator starting wafer. Two such arrays are produced from a single wafer along with witness samples for process characterization. To provide thermal isolation for the detector elements, at the end of the process over 90% of the silicon must be removed using deep reactive ion etching techniques. The electrical connections for each bolometer element are patterned on the top edge of the square grid supporting the array. The design considerations unique to GISMO, key fabrication challenges, and laboratory experimental results will be presented.

  8. Resistance of a cultured fish cell line (CAF-MM1) to. gamma. irradiation

    SciTech Connect

    Mitani, H.; Etoh, H.; Egami, N.

    1982-02-01

    Fish are generally more resistant to whole-body ionizing radiation than mammals. To study the radiosensitivity of fish in vitro, CAF-MM1 cells derived from the fin of the goldfish, Carassius auratus, were used. The survival parameters of CAF-MM1 obtained after ..gamma.. irradiation at 26/sup 0/C were 325 rad for D/sub o/, 975 rad for Dq, and 15 for n. No mammalian cell line with such a low sensitivity in the presence of O/sub 2/ has been reported. It was found that the large initial shoulder of the survival curve was paralleled by substantial repair of sublethal damage as evidenced by split-dose experiments. This low sensitivity to ..gamma.. irradiation did not change upon the administration of caffeine or postirradiation illumination, although these treatments were effective after uv irradiation. The decrease in the mitotic index in CAF-MM1 occurred immediately after irradiation, and it recovered within a very short time. This indicated that the duration of G2 arrest was shorter than that observed in mammalian cells. The data also suggest that the resistance of fish to whole-body irradiation is attributable to resistance at the cellular level.

  9. A λ 3 mm and 1 mm line survey toward the yellow hypergiant IRC +10420. N-rich chemistry and IR flux variations

    NASA Astrophysics Data System (ADS)

    Quintana-Lacaci, G.; Agúndez, M.; Cernicharo, J.; Bujarrabal, V.; Sánchez Contreras, C.; Castro-Carrizo, A.; Alcolea, J.

    2016-07-01

    Aims: Our knowledge of the chemical properties of the circumstellar ejecta of the most massive evolved stars is particularly poor. We aim to study the chemical characteristics of the prototypical yellow hypergiant star, IRC +10420. For this purpose, we obtained full line surveys at 1 and 3 mm atmospheric windows. Methods: We have identified 106 molecular emission lines from 22 molecular species. Approximately half of the molecules detected are N-bearing species, in particular HCN, HNC, CN, NO, NS, PN, and N2H+. We used rotational diagrams to derive the density and rotational temperature of the different molecular species detected. We introduced an iterative method that allows us to take moderate line opacities into account. Results: We have found that IRC +10420 presents high abundances of the N-bearing molecules compared with O-rich evolved stars. This result supports the presence of a N-rich chemistry, expected for massive stars. Our analysis also suggests a decrease of the 12C/13C ratio from ≳ 7 to ~3.7 in the last 3800 yr, which can be directly related to the nitrogen enrichment observed. In addition, we found that SiO emission presents a significant intensity decrease for high-J lines when compared with older observations. Radiative transfer modeling shows that this variation can be explained by a decrease in the infrared (IR) flux of the dust. The origin of this decrease might be an expansion of the dust shell or a lower stellar temperature due to the pulsation of the star. Based on observations carried out with the IRAM 30 m Telescope. IRAM is supported by INSU/CNRS (France), MPG (Germany) and IGN (Spain).The reduced spectra (FITS files) are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/592/A51

  10. Fabrication of ф 160 mm convex hyperbolic mirror for remote sensing instrument

    NASA Astrophysics Data System (ADS)

    Kuo, Ching-Hsiang; Yu, Zong-Ru; Ho, Cheng-Fang; Hsu, Wei-Yao; Chen, Fong-Zhi

    2012-10-01

    In this study, efficient polishing processes with inspection procedures for a large convex hyperbolic mirror of Cassegrain optical system are presented. The polishing process combines the techniques of conventional lapping and CNC polishing. We apply the conventional spherical lapping process to quickly remove the sub-surface damage (SSD) layer caused by grinding process and to get the accurate radius of best-fit sphere (BFS) of aspheric surface with fine surface texture simultaneously. Thus the removed material for aspherization process can be minimized and the polishing time for SSD removal can also be reduced substantially. The inspection procedure was carried out by using phase shift interferometer with CGH and stitching technique. To acquire the real surface form error of each sub aperture, the wavefront errors of the reference flat and CGH flat due to gravity effect of the vertical setup are calibrated in advance. Subsequently, we stitch 10 calibrated sub-aperture surface form errors to establish the whole irregularity of the mirror in 160 mm diameter for correction polishing. The final result of the In this study, efficient polishing processes with inspection procedures for a large convex hyperbolic mirror of Cassegrain optical system are presented. The polishing process combines the techniques of conventional lapping and CNC polishing. We apply the conventional spherical lapping process to quickly remove the sub-surface damage (SSD) layer caused by grinding process and to get the accurate radius of best-fit sphere (BFS) of aspheric surface with fine surface texture simultaneously. Thus the removed material for aspherization process can be minimized and the polishing time for SSD removal can also be reduced substantially. The inspection procedure was carried out by using phase shift interferometer with CGH and stitching technique. To acquire the real surface form error of each sub aperture, the wavefront errors of the reference flat and CGH flat due to

  11. CHIME monazite dating using FE-EPMA equipped with R=100 mm spectrometers

    NASA Astrophysics Data System (ADS)

    Shibata, K.; Shimizu, M.; Suzuki, K.; Sueoka, S.; Niwa, M.

    2015-12-01

    The age spectrum of detrital monazite grains is used to unravel the tectono-thermal history of the pre-Neogene terranes, which is required for geological disposal of high-level radioactive waste on tectonically active Japanese Islands. The CHIME (Chemical Th-U-total Pb isochron method, Suzuki and Adachi, 1991) is best suited for dating of detrital monazite whose grains are not chronologically uniform. In the previous studies (eg, Suzuki, 2011), EPMA equipped with conventional R=140 mm spectrometers was used for measurement of U, Th and Pb. However the spectrometers have low count rate of measurement of Pb. The JEOL JXA-8530F FE-EPMA equipped with R=100 mm spectrometers has been applied for the CHIME monazite dating. The intrinsic responses of each of the R=100 mm spectrometers for PbMβ are around ten times higher than that of the R=140 mm spectrometer. The R=100 mm spectrometers permits obtaining high count rate, which enables us to shorten measurement time than before. As these spectrometers have peculiar spectral interference, the method reported by Amli and Griffin (1978) is applied for correction of the interference. In order to verify the dating using the FE-EPMA and the interference correction method, two distinct age groups of monazite were measured. The ages were 425±25 Ma for monazite from Cooma granite in southeastern Australia, which had dated by SHRIMP as 432.8 ± 3.5 Ma (Williams, 2001) and 67 ± 7 Ma for monazite of the Kojaku granite in southwestern Japan, which is corresponding to the LA-ICP-MS U-Pb zircon ages of 68.5 ± 0.7 Ma. These results indicate that the FE-EPMA and the interference correction method are useful for the CHIME monazite dating and for revealing the tectono-thermal history of the terranes. This study was carried out under a contract with Agency of Natural Resources and Energy(ANRE), part of Ministry of Economy, Trade and Industry (METI) of Japan as part of its R&D supporting program for developing geological disposal technology.

  12. Development of linear scaling QM/MM methods using BRABO/CHARMM

    NASA Astrophysics Data System (ADS)

    Swerts, Benjamin

    As we focus on the quantum mechanical (QM) description of large molecular systems in our research group, the goal of my research was extending the size-limit of molecular systems through the use of QM/MM. In this type of calculation, a small region of the system is described by quantum mechanics while the remaining bulk is described by molecular mechanics (MM). As a first step, the BRABO program package was interfaced with the MM program CHARMM, which is optimised for biomolecules. In the simplest implementation of QM/MM, the QM and MM regions are comprised of entire molecules and consequently interact only through nonbonded interactions: electrostatics and Van der Waals interactions. On this basis, two models for the description of molecular crystals were developed. With BRABO it was possible to do cluster calculations with the Point Charge (PC) and Supermolecule (SM) models. In the cluster model, a central molecule is surrounded by identical molecules arranged according to its space group symmetry. In the PC model, the surrounding molecules are represented by ab initio charges placed on the atomic positions. In the SM model, the nearest neighbours are also included in the wavefunction. The two new QM/MM models are based thereon and named the Extended Point Charge (PCX) and Extended Supermolecule (SMX) models. The main differences lie in the addition of classical Van der Waals interactions between the central molecule and the neighbours, and the different type of electrostatics: fixed force field charges versus geometry dependent ab initio charges. The PCX and SMX models were tested on a number of organic crystals, including formamide oxime, alpha-glycine, and the yellow form of dimethyl 3,6-dichloro-2,5-dihydroxyterephthalate. It was concluded that the PCX and SMX models can give a significant improvement over the ab initio cluster models. With the PCX model, results of SM quality can be obtained at PC cost. With the SMX model, increased accuracy can be obtained

  13. Acceleration of Ab Initio QM/MM Calculations under Periodic Boundary Conditions by Multiscale and Multiple Time Step Approaches.

    PubMed

    Nam, Kwangho

    2014-10-14

    Development of multiscale ab initio quantum mechanical and molecular mechanical (AI-QM/MM) method for periodic boundary molecular dynamics (MD) simulations and their acceleration by multiple time step approach are described. The developed method achieves accuracy and efficiency by integrating the AI-QM/MM level of theory and the previously developed semiempirical (SE) QM/MM-Ewald sum method [J. Chem. Theory Comput. 2005, 1, 2] extended to the smooth particle-mesh Ewald (PME) summation method. In the developed methods, the total energy of the simulated system is evaluated at the SE-QM/MM-PME level of theory to include long-range QM/MM electrostatic interactions, which is then corrected on the fly using the AI-QM/MM level of theory within the real space cutoff. The resulting energy expression enables decomposition of total forces applied to each atom into forces determined at the low-level SE-QM/MM method and correction forces at the AI-QM/MM level, to integrate the system using the reversible reference system propagator algorithm. The resulting method achieves a substantial speed-up of the entire calculation by minimizing the number of time-consuming energy and gradient evaluations at the AI-QM/MM level. Test calculations show that the developed multiple time step AI-QM/MM method yields MD trajectories and potential of mean force profiles comparable to single time step QM/MM results. The developed method, together with message passing interface (MPI) parallelization, accelerates the present AI-QM/MM MD simulations about 30-fold relative to the speed of single-core AI-QM/MM simulations for the molecular systems tested in the present work, making the method less than one order slower than the SE-QM/MM methods under periodic boundary conditions.

  14. A field comparison of the IOM inhalable aerosol sampler and a modified 37-mm cassette.

    PubMed

    Clinkenbeard, R E; England, E C; Johnson, D L; Esmen, N A; Hall, T A

    2002-09-01

    This research focused on comparing a modified 37-mm (Mod37) sampling cassette with an IOM inhalable dust sampler. Paired IOM and Mod37 breathing-zone air samples were collected for workers engaged in corrosion control maintenance operations on several types of aircraft at several U.S. Air Force bases in the United States. Sampled operations included hand and power sanding, blow-down and wipe-down to remove dust, and spray finishing. The cassettes' interior surfaces were swabbed and the swabs combined with the filters for chromium analysis by NIOSH Method 7300. This approach utilized total chromium as a sensitive surrogate indicator of total aspirated mass. The influences of work location, work type, sample duration, and sampler type on measured concentration were evaluated using analysis of variance techniques. Only work type (process) was found to be a statistically significant predictor of measured concentration. The relationship between IOM- and Mod37-measured values for paired samples was evaluated by work type using linear regression techniques. Linear regressions showed that the modified 37-mm cassette over-samples aerosol by 35 percent compared to the IOM when a wide range of aerosol concentrations and compositions for divergent work tasks in multiple field locations are sampled. Interpretation of these results in light of previous results involving filter-only Mod37 analyses suggests that while the Mod37 has a higher aspiration efficiency than the IOM, substantial Mod37 wall losses result in underestimation of exposure when only the 37-mm filter is analyzed rather than filters plus wall swabs.

  15. Daily dosimetric quality control of the MM50 Racetrack Microtron using an electronic portal imaging device.

    PubMed

    Dirkx, M L; Kroonwijk, M; de Boer, J C; Heijmen, B J

    1995-10-01

    The MM50 Racetrack Microtron, suited for advanced three-dimensional conformal radiotherapy techniques, is a complex machine in various respects. Therefore, for a number of gantry angles, daily quality control of the absolute output and fluence profiles of the scanned beams are mandatory. For the applied photon beams, a fast method for these daily checks, based on dosimetric measurements with the Philips SRI-100 Electronic Portal Imaging Device (EPID), has been developed and tested. Open beams are checked for four different gantry angles; for gantry angle 0, a wedged field is checked as well. Performing and analyzing the measurements takes about 10 min. The applied EPID has favourable characteristics for dosimetric quality control measurements: absolute output measurements reproduce within 0.5% (1 SD) and the reproducibility of relative (2D) beam profile measurements is 0.2% (1 SD). The day-to-day sensitivity stability over a period of one month is 0.6% (1 SD). Measured grey scale values are within 0.2% linear with the applied dose. The 2D fluence profile of the 25 MV photon beam of the MM50 is very stable in time: during a period of 5 months a maximum fluctuation of 2.2% has been observed. Once, a deviation in the cGy/MU-value of 6% was detected. There is no interlock in the MM50-system that would have prevented patient treatment with this strongly deviating output. Based on the results of this study and on clinical requirements regarding acceptability of deviations of beam characteristics, a protocol has been developed including action levels for additional investigations and, if necessary, adjustment of the beam characteristics.

  16. L1448-MM OBSERVATIONS BY THE HERSCHEL KEY PROGRAM, ''DUST, ICE, AND GAS IN TIME'' (DIGIT)

    SciTech Connect

    Lee, Jinhee; Lee, Jeong-Eun; Lee, Seokho; Green, Joel D.; Evans, Neal J. II; Choi, Minho; Kristensen, Lars; Dionatos, Odysseas; Jørgensen, Jes K.; Collaboration: DIGIT Team

    2013-11-01

    We present Herschel/Photodetector Array Camera and Spectrometer (PACS) observations of L1448-MM, a Class 0 protostar with a prominent outflow. Numerous emission lines are detected at 55 <λ < 210 μm including CO, OH, H{sub 2}O, and [O I]. We investigate the spatial distribution of each transition to find that lines from low energy levels tend to distribute along the outflow direction while lines from high energy levels peak at the central spatial pixel. Spatial maps reveal that OH emission lines are formed in a relatively small area, while [O I] emission is extended. According to the rotational diagram analysis, the CO emission can be fitted by two (warm and hot) temperature components. For H{sub 2}O, the ortho-to-para ratio is close to 3. The non-LTE large velocity gradient (LVG) calculations suggest that CO and H{sub 2}O lines could instead be formed in a high kinetic temperature (T > 1000 K) environment, indicative of a shock origin. For OH, IR-pumping processes play an important role in the level population. The molecular emission in L1448-MM is better explained with a C-shock model, but the atomic emission of PACS [O I] and Spitzer/Infrared Spectrograph [Si II] emission is not consistent with C-shocks, suggesting multiple shocks in this region. Water is the major line coolant of L1448-MM in the PACS wavelength range, and the best-fit LVG models predict that H{sub 2}O and CO emit (50%-80%) of their line luminosity in the PACS wavelength range.

  17. Fine Structure in the Mm-Wavelength Spectra of the Active Region

    NASA Astrophysics Data System (ADS)

    Sawant, H. S.; Cecatto, J. R.

    1990-11-01

    RESUMEN. Faltan observaciones solares espectrosc6picas en la longitud de onda milimetrica. Hay sugerencias de que se puede superponer una fi na estructura en frecuencia a la componente-S de la regi6n solar activa, asi como a la componente del brote en las longitudes de onda milimetri- cas. Se ha desarrollado un receptor de alta sensibilidad de pasos de frecuencia que opera en el intervalo de 23-18 GHz con una resoluci6n de 1 GHz y resoluci6n de tiempo variable entre 1.2 y 96 sec, usando la an- tena de Itapetinga de 13.7-m para estudiar la estructura fina en frecuencia y tiempo. Discutimos el espectro en longitud de onda-mm en re- giones activas y su evoluci6n en el tiempo. El estudio de Ia evoluci6n en el tiempo de la regi6n activa en AR 5569 observada el 29 de junio de 1989, sugiere la existencia de estructuras finas como funci6n deltiempo. ABSTRACT. There is a lack of mm-wavelength spectroscopic solar observations. There are suggestions that a fine structure in frequency may be superimposed on the S-component of solar active region as well as on the burst component at inm-wavelengths. To study fine structure in frequency and time, a high sensitivity step frequency receiver operating in the frequency range 23-18 GHz with frequency resolution of 1 GHz and variable time resolution 1.2 to 96 sec, using 13.7 m diameter Itapetinga radome covered antenna, has been developed. Here, we discuss mm-wavelength spectra of active regions and their time evolution. Study of time evolution of an active region AR 5569 observed on 29th June, 1989 suggests existence of fine structures as a function of time. ( Ck : SUN-ACTIVITY - SUN-RADIO RADIATION

  18. How to form planetesimals from mm-sized chondrules and chondrule aggregates

    NASA Astrophysics Data System (ADS)

    Carrera, Daniel; Johansen, Anders; Davies, Melvyn B.

    2015-07-01

    The size distribution of asteroids and Kuiper belt objects in the solar system is difficult to reconcile with a bottom-up formation scenario due to the observed scarcity of objects smaller than ~100 km in size. Instead, planetesimals appear to form top-down, with large 100-1000 km bodies forming from the rapid gravitational collapse of dense clumps of small solid particles. In this paper we investigate the conditions under which solid particles can form dense clumps in a protoplanetary disk. We used a hydrodynamic code to model the interaction between solid particles and the gas inside a shearing box inside the disk, considering particle sizes from submillimeter-sized chondrules to meter-sized rocks. We found that particles down to millimeter sizes can form dense particle clouds through the run-away convergence of radial drift known as the streaming instability. We made a map of the range of conditions (strength of turbulence, particle mass-loading, disk mass, and distance to the star) that are prone to producing dense particle clumps. Finally, we estimate the distribution of collision speeds between mm-sized particles. We calculated the rate of sticking collisions and obtain a robust upper limit on the particle growth timescale of ~105 years. This means that mm-sized chondrule aggregates can grow on a timescale much smaller than the disk accretion timescale (~106-107 years). Our results suggest a pathway from the mm-sized grains found in primitive meteorites to fully formed asteroids. We speculate that asteroids may form from a positive feedback loop in which coagualation leads to particle clumping driven by the streaming instability. This clumping, in turn, reduces collision speeds and enhances coagulation. Future simulations should model coagulation and the streaming instability together to explore this feedback loop further. Appendices are available in electronic form at http://www.aanda.org

  19. Liquid Methanol from DFT and DFT/MM Molecular Dynamics Simulations.

    PubMed

    Sieffert, Nicolas; Bühl, Michael; Gaigeot, Marie-Pierre; Morrison, Carole A

    2013-01-08

    We present a comparative study of computational protocols for the description of liquid methanol from ab initio molecular dynamics simulations, in view of further applications directed at the modeling of chemical reactivity of organic and organometallic molecules in (explicit) methanol solution. We tested density functional theory molecular dynamics (DFT-MD) in its Car-Parrinello Molecular Dynamics (CPMD) and Quickstep/Born-Oppenheimer MD (CP2K) implementations, employing six popular density functionals with and without corrections for dispersion interactions (namely BLYP, BLYP-D2, BLYP-D3, BP86, BP86-D2, and B97-D2). Selected functionals were also tested within the two QM/MM frameworks implemented in CPMD and CP2K, considering one DFT molecule in a MM environment (described by the OPLS model of methanol). The accuracy of each of these methods at describing the bulk liquid phase under ambient conditions was evaluated by analyzing their ability to reproduce (i) the average structure of the liquid, (ii) the mean squared displacement of methanol molecules, (iii) the average molecular dipole moments, and (iv) the gas-to-liquid red-shift observed in their infrared spectra. We show that it is difficult to find a DFT functional that describes these four properties equally well within full DFT-MD simulations, despite a good overall performance of B97-D2. On the other hand, DFT/MM-MD provides a satisfactory description of the solvent-solute polarization effects with all functionals and thus represents a good alternative for the modeling of methanol solutions in the context of chemical reactivity in an explicit environment.

  20. A MOLECULAR EINSTEIN RING TOWARD THE z = 3.93 SUBMILLIMETER GALAXY MM18423+5938

    SciTech Connect

    Lestrade, Jean-Francois; Carilli, Chris L.; Thanjavur, Karun; Kneib, Jean-Paul; Riechers, Dominik A.; Bertoldi, Frank; Walter, Fabian; Omont, Alain

    2011-09-20

    We present high-resolution imaging of the low-order (J = 1 and 2) CO line emission from the z = 3.93 submillimeter galaxy (SMG) MM18423+5938 using the Expanded Very Large Array, and optical and near-IR imaging using the Canada-France-Hawaii Telescope. This SMG with a spectroscopic redshift was thought to be gravitationally lensed given its enormous apparent brightness. We find that the CO emission is consistent with a complete Einstein ring with a major axis diameter of {approx}1.''4, indicative of lensing. We have also identified the lensing galaxy as a very red elliptical coincident with the geometric center of the ring and estimated its photometric redshift z {approx} 1.1. A first estimate of the lens magnification factor is m {approx} 12. The luminosity L'{sub CO(1-0)} of the CO(1-0) emission is 2.71 {+-} 0.38 x 10{sup 11} m {sup -1} K km s{sup -1} pc{sup 2}, and, adopting the commonly used conversion factor for ultraluminous infrared galaxies (ULIRGs), the molecular gas mass is M(H{sub 2}) = 2.2 x 10{sup 11} m {sup -1} M{sub sun}, comparable to unlensed SMGs if corrected by m {approx} 12. Our revised estimate of the far-IR luminosity of MM18423+5938 is 2 x 10{sup 13} m {sup -1} < L{sub FIR} < 3 x 10{sup 14} m {sup -1} L{sub sun}, comparable to that of ULIRGs. Further observations are required to quantify the star formation rate in MM18423+5938 and to constrain the mass model of the lens in more detail.

  1. Ejector/liquid ring pump provides <0. 30 mm Hg vacuum for polymerization vessel

    SciTech Connect

    Lockwood, A.; Gaines, A.

    1982-03-01

    Firestone Fibers and Textiles Company, a division of Firestone Tire and Rubber Company, manufactures tire and industrial yarns of polyester and nylon-6. Nylon-6 molding and extrusion resins are also produced at the plant in Hopewell, Virginia. The process for making polyester requires an extremely low vacuum on the polymerization reactor. A consistent polymerization vessel vacuum of 0.3 mm Hg is needed, but the existing vacuum source, a five-stage steam jet ejector, could only provide a 0.5 mm Hg level. Two options were considered when the company decided to replace the original system with a system designed for 0.15 mm Hg with a non-condensible gas load of 10.8 lb/hr. A new five-stage jet ejector system to meet these requirements would use 1395 lb/hr of 100 psig steam. The other option was a hybrid vacuum source composed of a three-stage steam ejector system and a liquid ring vacuum pump that is more energy efficient than ejectors for low vacuum applications. The hybrid system was selected because the three-stage jet ejector would use only 1240 lb/hr of 100 psig steam. The liquid ring vacuum pump would increase the material and installation cost of the system by about $4000, but the savings in steam consumption would pay back the added cost in less than two years. The jet ejector/liquid ring vacuum pump system has provided both the capacity and the extremely low vacuum needed for the polyester polymerization vessel, after making a small modification. The hybrid vacuum source is reliable, requires only routine maintenance, and will contiue to save substantial amounts of steam each year compared to the five-stage steam jet ejector.

  2. Towards the 1 mm/y Stability of the Radial Orbit Error at Regional Scales

    NASA Technical Reports Server (NTRS)

    Couhert, Alexandre; Cerri, Luca; Legeais, Jean-Francois; Ablain, Michael; Zelensky, Nikita P.; Haines, Bruce J.; Lemoine, Frank G.; Bertiger, William I.; Desai, Shailen D.; Otten, Michiel

    2015-01-01

    An estimated orbit error budget for the Jason-1 and Jason-2 GDR-D solutions is constructed, using several measures of orbit error. The focus is on the long-term stability of the orbit time series for mean sea level applications on a regional scale. We discuss various issues related to the assessment of radial orbit error trends; in particular this study reviews orbit errors dependent on the tracking technique, with an aim to monitoring the long-term stability of all available tracking systems operating on Jason-1 and Jason-2 (GPS, DORIS, SLR). The reference frame accuracy and its effect on Jason orbit is assessed. We also examine the impact of analysis method on the inference of Geographically Correlated Errors as well as the significance of estimated radial orbit error trends versus the time span of the analysis. Thus a long-term error budget of the 10-year Jason-1 and Envisat GDR-D orbit time series is provided for two time scales: interannual and decadal. As the temporal variations of the geopotential remain one of the primary limitations in the Precision Orbit Determination modeling, the overall accuracy of the Jason-1 and Jason-2 GDR-D solutions is evaluated through comparison with external orbits based on different time-variable gravity models. This contribution is limited to an East-West "order-1" pattern at the 2 mm/y level (secular) and 4 mm level (seasonal), over the Jason-2 lifetime. The possibility of achieving sub-mm/y radial orbit stability over interannual and decadal periods at regional scales and the challenge of evaluating such an improvement using in situ independent data is discussed.

  3. Thermodynamics calculation of protein-ligand interactions by QM/MM polarizable charge parameters.

    PubMed

    Wang, Jinan; Shao, Qiang; Cossins, Benjamin P; Shi, Jiye; Chen, Kaixian; Zhu, Weiliang

    2016-01-01

    The calculation of protein-ligand binding free energy (ΔG) is of great importance for virtual screening and drug design. Molecular dynamics (MD) simulation has been an attractive tool to investigate this scientific problem. However, the reliability of such approach is affected by many factors including electrostatic interaction calculation. Here, we present a practical protocol using quantum mechanics/molecular mechanics (QM/MM) calculations to generate polarizable QM protein charge (QMPC). The calculated QMPC of some atoms in binding pockets was obviously different from that calculated by AMBER ff03, which might significantly affect the calculated ΔG. To evaluate the effect, the MD simulations and MM/GBSA calculation with QMPC for 10 protein-ligand complexes, and the simulation results were then compared to those with the AMBER ff03 force field and experimental results. The correlation coefficient between the calculated ΔΔG using MM/GBSA under QMPC and the experimental data is .92, while that with AMBER ff03 force field is .47 for the complexes formed by streptavidin or its mutants and biotin. Moreover, the calculated ΔΔG with QMPC for the complexes formed by ERβ and five ligands is positively related to experimental result with correlation coefficient of .61, while that with AMBER ff03 charge is negatively related to experimental data with correlation coefficient of .42. The detailed analysis shows that the electrostatic polarization introduced by QMPC affects the electrostatic contribution to the binding affinity and thus, leads to better correlation with experimental data. Therefore, this approach should be useful to virtual screening and drug design.

  4. Multimodal Broadband Vibrational Sum Frequency Generation (MM-BB-V-SFG) Spectrometer and Microscope.

    PubMed

    Lee, Christopher M; Kafle, Kabindra; Huang, Shixin; Kim, Seong H

    2016-01-14

    A broadband sum frequency generation (BB-SFG) spectrometer with multimodal (MM) capabilities was constructed, which could be routinely reconfigured for tabletop experiments in reflection, transmission, and total internal reflection (TIR) geometries, as well as microscopic imaging. The system was constructed using a Ti:sapphire amplifier (800 nm, pulse width = 85 fs, repetition rate = 2 kHz), an optical parameter amplification (OPA) system for production of broadband IR pulses tunable between 1000 and 4000 cm(-1), and two Fabry-Pérot etalons arranged in series for production of narrowband 800 nm pulses. The key feature allowing the MM operation was the nearly collinear alignment of the visible (fixed, 800 nm) and infrared (tunable, 1000-4000 cm(-1)) pulses which were spatially separated. Physical insights discussed in this paper include the comparison of spectral bandwidth produced with 40 and 85 fs pump beams, the improvement of spectral resolution using etalons, the SFG probe volume in bulk analysis, the normalization of SFG signals, the stitching of multiple spectral segments, and the operation in different modes for air/liquid and adsorbate/solid interfaces, bulk samples, as well as spectral imaging combined with principle component analysis (PCA). The SFG spectral features obtained with the MM-BB-SFG system were compared with those obtained with picosecond-scanning-SFG system and high-resolution BB-SFG system (HR-BB-SFG) for dimethyl sulfoxide, α-pinene, and various samples containing cellulose (purified commercial products, Cladophora cell wall, cotton and flax fibers, and onion epidermis cell wall).

  5. Use of a 35mm camera for remote surface cleanliness verification

    NASA Technical Reports Server (NTRS)

    Crutcher, E. R.

    1986-01-01

    Non-contact or remote monitoring of surfaces for both particle and molecular contaminants is required for verification of surface cleanliness on many program subsystems. The capability of a 35mm camera to satisfy this need is presented. The many limitations imposed by standard available lens systems are compared to actual required sensitivities. Methods of optimizing camera systems for specific applications and descriptions of support systems for extending the range of usefulness of the recorded data are also provided. Although this general concept is not new, significant improvements in the technique involving the use of polarized light and diffraction effects have resulted in a more efficient utilization of information recorded on the film.

  6. CONFLEX/MM3 search/minimization study of the conformations of the macrolide antibiotic tylosin

    NASA Astrophysics Data System (ADS)

    Ivanov, Petko M.

    2002-03-01

    The conformations of the 16-membered macrolide antibiotic tylosin were studied with the MM3 force field. The CONFLEX conformational search procedure was used for finding low-energy conformations. The computed data are indicative for the existence of several conformations in equilibrium. The intramolecular hydrogen bonds play an important role for the preferred geometry of the macroring and the conformations of the side chains. The present results provide further insight into the most probable conformations of tylosin and compliment an earlier analysis based on NMR techniques.

  7. Results on the existence of the Yamabe minimizer of Mm×R

    NASA Astrophysics Data System (ADS)

    Ruiz, Juan Miguel

    2012-01-01

    We let (Mm,g) be a closed smooth Riemannian manifold with positive scalar curvature Sg, and prove that the Yamabe constant of (M×R,g+gE) ( n,m≥2) is achieved by a metric in the conformal class of (g+gE), where gE is the Euclidean metric. We do this by showing that the Yamabe functional of (M×R,g+gE) is improved under Steiner symmetrization with respect to M, and so, the dependence on R of the Yamabe minimizer of (M×R,g+gE) is radial.

  8. 3 mm Anisotropy Measurement: On the Quadrupole Component in theCosmic Background Radiation

    SciTech Connect

    Lubin, Philip M.; Epstein, Gerald L.; Smoot, George F.

    1982-11-01

    We have mapped the large-scale anisotropy in the cosmic background radiation at 3 mm wavelength using a liquid-helium-cooled balloon-borne radiometer sensitive enough to detect the dipole in one gondola rotation (1 minute). Statistical errors on the dipole and quadrupole components are below 0.1 mK with less than 0.1 m K galactic contribution. We find a dipole consistent with previous measurements but disagree with recent quadrupole reports. The measurement is also useful in searching for spectral distortions.

  9. Estimation of Microphysical and Radiative Parameters of Precipitating Cloud Systems Using mm-Wavelength Radars

    NASA Astrophysics Data System (ADS)

    Matrosov, Sergey Y.

    2009-03-01

    A remote sensing approach is described to retrieve cloud and rainfall parameters within the same precipitating system. This approach is based on mm-wavelength radar signal attenuation effects which are observed in a layer of liquid precipitation containing clouds and rainfall. The parameters of ice clouds in the upper part of startiform precipitating systems are then retrieved using the absolute measurements of radar reflectivity. In case of the ground-based radar location, these measurements are corrected for attenuation in the intervening layer of liquid hydrometers.

  10. A New Glow on the Chromatography of M&M Candies

    NASA Astrophysics Data System (ADS)

    Birdwhistell, Kurt R.; Spence, Thomas G.

    2002-07-01

    This lab experiment for undergraduate or high school students presents the separation and analysis of dyes in the candy shell of M&M chocolate candies. The dyes in the shells of M&Ms are separated using paper chromatography and are identified by comparison of the Rf values, color, and fluorescence properties with those of standard FD&C ([U.S. Federal] Food, Drug, and Cosmetic Act) dyes. The experiment introduces students to chromatography of mixtures, compound identification by using Rf values, and fluorescence. They learn about fluorescence and how it appears in everyday substances and can be used to help identify compounds.

  11. ReaDDyMM: Fast Interacting Particle Reaction-Diffusion Simulations Using Graphical Processing Units

    PubMed Central

    Biedermann, Johann; Ullrich, Alexander; Schöneberg, Johannes; Noé, Frank

    2015-01-01

    ReaDDy is a modular particle simulation package combining off-lattice reaction kinetics with arbitrary particle interaction forces. Here we present a graphical processing unit implementation of ReaDDy that employs the fast multiplatform molecular dynamics package OpenMM. A speedup of up to two orders of magnitude is demonstrated, giving us access to timescales of multiple seconds on single graphical processing units. This opens up the possibility of simulating cellular signal transduction events while resolving all protein copies. PMID:25650912

  12. Actuators with 10 mm stroke and less than 300 nm of runout

    NASA Astrophysics Data System (ADS)

    Hatheway, Alson E.

    2007-09-01

    All-elastic motorized flexure stages have been developed for critical metrology applications where X-Y runout of the motion must be less than 300 nm over a 10 mm stroke. The design was adapted from a highly stable flat-blade flexure stage that was manually driven and used in several instruments where long term stability of adjustments were important. The adaptations included a motor-driven miniature ball screw, a Z axis position sensor repeatable to 10 microns and elastic strain relief between the ball nut and the driven table. In-situ testing of the actuators demonstrated that they met or exceeded all specifications for their performance.

  13. Photodynamic therapy for Barrett's esophagus using a 20-mm diameter light-delivery balloon

    NASA Astrophysics Data System (ADS)

    Panjehpour, Masoud; Overholt, Bergein F.; Phan, Mary N.; Haydek, John M.; Robinson, Amy R.

    2002-06-01

    Background and Objective: Patients with high grade dysplasia (HGD) in Barrett's esophagus are at a high risk for developing esophageal adenocarcinoma. Esophagectomy is the standard treatment for such patients. The objective of this study was to evaluate the safety and efficacy of photodynamic therapy (PDT) using an improved light delivery balloon for ablation of Barrett's esophagus with high grade dysplasia and/or early cancer. Materials and Methods: 20 patients with HGD or early cancer (19 with HGD, 1 with T1 cancer) received 2 mg/kg of porfimer sodium, intravenously. Two to three days after the injection, laser light was delivered using a cylindrical diffuser inserted inside a 20-mm diameter reflective esophageal PDT balloon. Initially, the balloon was inflated to a pressure of 80 mm Hg. The balloon pressure was gradually reduced to 30 mm Hg. A KTP/dye laser at 630 nm was used as the light source. Light dose of 115 J/cm was delivered at an intensity of 270 mw/cm. Nodules were pre- treated with an extra 50 J/cm using a short diffuser inserted through the scope. Patients were maintained on PPI therapy to keep the gastric pH higher than 4. Eighteen patients required one treatment, while two patients were treated twice. Follow-up consisted of endoscopy with four quadrant biopsies at every 2 cm of the treated area. Thermal ablation was used to treat small residual islands on the follow-ups. The follow-up endoscopies ranged from 6 to 17 months. Results: On follow-up endoscopy, 12 patients had complete replacement of their Barrett's mucosa with neosquamous mucosa. Five patients had residual non-dysplastic Barrett's mucosa, one had indefinite dysplasia, two had low grad dysplasia. There were no residual HGD or cancers. The average length of Barrett's was reduced from 5.4 cm to 1.2 cm. High balloon pressure resulted in wide variation in PDT response among patients. Lower balloon pressures resulted in more consistent destruction of Barrett's mucosa among patients. Five

  14. Application of MM5/CMAQ for modelling urban air pollution a case study for London, UK

    NASA Astrophysics Data System (ADS)

    Kitwiroon, N.; Fragkou, E.; Sokhi, R. S.; San Jose, R.; Pérez Camaño, J. L.; Middleton, D.

    2003-04-01

    Urban air pollution has been particularly studied for the last few decades because of its recognised environmental dangers and health implications. The complexity of the urban surface characteristics and turbulence patterns has dictated the use of numerical models by environmental research agencies and regulators in order to predict and manage urban air pollution. However, most of these models are not specifically adapted to urban applications and normally do not include detailed urban parameterisation, such as for surface roughness or urban heat fluxes. Flow structure and dispersion of air pollutants within cities, however, are influenced by urban features such as increased surface roughness. This paper presents a study using MM5 and CMAQ to assess the effect of urban boundary layer features on meteorological parameters, and hence London's air quality. MM5 is a non-hydrostatic (version 3), terrain-following sigma-coordinate model designed to simulate mesoscale and regional-scale atmospheric circulation. This paper employs an improved surface roughness treatment on meteorological profiles and pollution dispersion. A surface roughness scale has been developed for London and the surrounding region. The land cover data was derived from the Centre for Ecology and Hydrology (CEH) data, with a spatial resolution of 25 × 25 m. These z_o values are employed with MM5 for modelling meteorological parameters over London, covering an inner domain area of 49 × 49 km. The outputs of MM5 have been coupled to CMAQ photochemical model to predict concentrations of particles, NO_2 and O_3 for London and the surrounding regions at a spatial resolution of 1 × 1 km. The predicted concentrations have been compared with monitored data obtained from a range of national air quality monitoring sites including Central London (Bloomsbury, Brent), East London (Bexley) and West London (Hillingdon). Comparison of hourly model predictions with measured data is made for pollution levels for

  15. An eight channel co-boresighted mm-wave receiver system

    NASA Astrophysics Data System (ADS)

    Moore, E. L.; Audette, D. J.

    1992-10-01

    A mm-wave sensor design with eight coboresighted beams spanning two octaves of continuous frequencies is described. The sensor system consists of a high/low gain Cassegrain antenna, a quasi-optical multiplexer, and cooled receivers operating in a frequency range of 30 to 110 GHz in eight 10 GHz wide channels. The Cassegrain antenna switches between high and low gain as the subreflector translates in and out of the beam. Quasi-optical focusing highpass filters separate the wideband bean into eight channels. All bands are observed simultaneously and adjacent bands are detected in orthogonal linear polarization.

  16. [What happens when mmHg are replaced by kPa? (author's transl)].

    PubMed

    Stepanik, J

    1981-12-01

    Resolution no. 30.39 of the WHA, passed in May 1977, recommends the adoption of SI units by the medical community throughout the world, including a change from mmHg to kPa. In Austria this requirement has been law since January 1978. This paper describes how simply the transition can be made and how other results, such as those of tonography and differential tonometry, are numerically altered as a result. Finally a simple modification is described which enables the Goldmann tonometer to indicate intraocular pressure, its kPa being equal to g on the scale.

  17. Design, Fabrication, and Testing of Lumped Element Kinetic inductance Detectors for 3 mm CMB Observations

    NASA Technical Reports Server (NTRS)

    Lowitz, Amy E.; Brown, Ari David; Stevenson, Thomas R.; Timbie, Peter T.; Wollack, Edward J.

    2014-01-01

    Kinetic inductance detectors (KIDs) are a promising technology for low-noise, highly-multiplexible mm- and submm-wave detection. KIDs have a number of advantages over other detector technologies, which make them an appealing option in the cosmic microwave background B-mode anisotropy search, including passive frequency domain multiplexing and relatively simple fabrication, but have suffered from challenges associated with noise control. Here we describe design and fabrication of a 20-pixel prototype array of lumped element molybdenum KIDs. We show Q, frequency and temperature measurements from the array under dark conditions. We also present evidence for a double superconducting gap in molybdenum.

  18. The control system of the 3 mm band SIS receiver for the Sardinia Radio Telescope

    NASA Astrophysics Data System (ADS)

    Ladu, A.; Ortu, P.; Saba, A.; Pili, M.; Guadiomonte, F.; Navarrini, A.; Urru, E.; Pisanu, T.; Valente, G.; Marongiu, P.; Mazzarella, G.

    2016-07-01

    We present the control system of the 84-116 GHz (3 mm band) Superconductor-Insulator-Superconductor (SIS) heterodyne receiver to be installed at the Gregorian focus of the Sardinia Radio Telescope (SRT). The control system is based on a single-board computer from Raspberry, on microcontrollers from Arduino, and on a Python program for communication between the receiver and the SRT antenna control software, which remotely controls the backshorttuned SIS mixer, the receiver calibration system and the Local Oscillator (LO) system.

  19. System level challenges of THz and mm-wave imaging systems

    NASA Astrophysics Data System (ADS)

    Tang, Adrian

    2016-05-01

    While THz and mm-wave imaging systems provide an interesting avenue for stand-off detection of concealed weapons and other threats without the need for ionizing radiation, there are many physical and technical obstacles which still prevent these systems from becoming commercially practical. This paper introduces the major issues for active and passive imaging including background masking, specular responses, and thermal equalization. Secondly, the paper discusses the prospects of radar imaging, and tradeoffs between system parameters such as transmit power, receiver sensitivity and phase noise, and how these parameters affect corresponding physical behavior including aperture size, resolution, penetration, and stand-off distance.

  20. Quantification of Multiple Cracks Using MM-wave Antenna Sensor Network

    DTIC Science & Technology

    2011-10-12

    Figure 5: passive antenna sensor with a light-activated RF switch. pHEMT Resistor Photocell DielectricPatch Figure 6: Wireless interrogation of...the gain of a patch antenna can be enhanced if it is surrounded by a metallic strip . For our sensor arrangement, the antenna sensor array that is not...Multiple Cracks Using MM-wave Antenna Sensor Network FA9550-08-l-0317 Sb. GRANT NUMBER Sc. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Sd. PROJECT NUMBER

  1. Exploring SCC-DFTB paths for mapping QM/MM reaction mechanisms.

    PubMed

    Woodcock, H Lee; Hodoscek, Milan; Brooks, Bernard R

    2007-07-05

    A new first-order procedure for locating transition structures (TS) that employs hybrid quantum mechanical/molecular mechanical (QM/MM) potentials has been developed. This new technique (RPATh+RESD) combines the replica path method (RPATh) and standard reaction coordinate driving (RCD) techniques in an approach that both efficiently determines reaction barriers and successfully eliminates two key weaknesses of RCD calculations (i.e., hysteresis/discontinuities in the path and the sequential nature of the RCD procedure). In addition, we have extended CHARMM's QM/MM reaction pathway methods, the RPATh and nudged elastic band (NEB) methods, to incorporate SCC-DFTB wave functions. This newly added functionality has been applied to the chorismate mutase-catalyzed interconversion of chorismate to prephenate, which is a key step in the shikimate pathway of bacteria, fungi, and other higher plants. The RPATh+RESD barrier height (DeltaE=5.7 kcal/mol) is in good agreement with previous results from full-energy surface mapping studies (Zhang, X.; Zhang, X.; Bruice, T. C. Biochemistry 2005, 44, 10443-10448). Full reaction paths were independently mapped with RPATh and NEB methods and showed good agreement with the final transition state from the RPATh+RESD "gold standard" and previous high-level QM/MM transition states (Woodcock, H. L.; Hodoscek, M.; Gilbert, T. B.; Gill, P. M. W.; Schaefer, H. F.; Brooks, B. R. J. Comput. Chem. 2007, 28, 1485-1502). The SCC-DFTB TS geometry most closely approximates the MP2/6-31+G(d) QM/MM result. However, the barrier height is underestimated and possibly points to an area for improvement in SCC-DFTB parametrization. In addition, the steepest descents (SD) minimizer for the NEB method was modified to uncouple the in-path and off-path degrees of freedom during the minimization, which significantly improved performance. The convergence behavior of the RPATh and NEB was examined for SCC-DFTB wave functions, and it was determined that, in general

  2. First Test Results of the 150 mm Aperture IR Quadrupole Models for the High Luminosity LHC

    SciTech Connect

    Ambrosio, G.; Chlachidze, G.; Wanderer, P.; Ferracin, P.; Sabbi, G.

    2016-10-06

    The High Luminosity upgrade of the LHC at CERN will use large aperture (150 mm) quadrupole magnets to focus the beams at the interaction points. The high field in the coils requires Nb3Sn superconductor technology, which has been brought to maturity by the LHC Accelerator Re-search Program (LARP) over the last 10 years. The key design targets for the new IR quadrupoles were established in 2012, and fabrication of model magnets started in 2014. This paper discusses the results from the first single short coil test and from the first short quadrupole model test. Remaining challenges and plans to address them are also presented and discussed.

  3. 2. West portal of Tunnel 38, view to east, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. West portal of Tunnel 38, view to east, 135mm lens. Note the notched wingwalls that support steel posts of entrance snowshed; these would have originally held timber posts of the original timber snowsheds, miles of which once enclosed and protected the railroad from the ravages of Sierra winters. Note also that these tunnels, built in the 1920s, have dispensed with any use of stone masonry, and instead have all-concrete portals. - Central Pacific Transcontinental Railroad, Tunnel No. 38, Milepost 180.58, Cisco, Placer County, CA

  4. 2. West portal of Tunnel 35, view to east, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. West portal of Tunnel 35, view to east, 135mm lens with electronic flash fill. Note the notched wingwalls that support steel posts of entrance snowshed; these would have originally held timber posts of the original timber snowsheds, miles of which once enclosed and protected the railroad from the ravages of Sierra winters. Note also that these tunnels, built in the 1920s, have dispensed with any use of stone masonry, and instead have all-concrete portals. - Central Pacific Transcontinental Railroad, Tunnel No. 35, Milepost 176.62, Yuba Pass, Nevada County, CA

  5. 2. West portal of Tunnel 37 view to eastsoutheast, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. West portal of Tunnel 37 view to east-southeast, 135mm lens. Note the notched wingwalls that would have originally held timber posts of the original timber snowsheds, miles of which once enclosed and protected the railroad from the ravages of Sierra winters. Note also that these tunnels, built in the 1920s, have dispensed with any use of stone masonry, and instead have all-concrete portals, though this tunnel retains the use of rubble granite slab slope protection flanking the portal. - Central Pacific Transcontinental Railroad, Tunnel No. 37, Milepost 177.79, Yuba Pass, Nevada County, CA

  6. 2. West portal of Tunnel 39, view to east, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. West portal of Tunnel 39, view to east, 135mm lens with electronic flash fill. Note the notched wingwalls that support steel posts of entrance snowshed; these would have originally held timber posts of the original timber snowsheds, miles of which once enclosed and protected the railroad from the ravages of Sierra winters. Note also that these tunnels, built in the 1920s, have dispensed with any use of stone masonry, and instead have all-concrete portals. - Central Pacific Transcontinental Railroad, Tunnel No. 39, Milepost 180.95, Cisco, Placer County, CA

  7. 3. West portal of Tunnel 23, view to north, 135mm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. West portal of Tunnel 23, view to north, 135mm lens. Concrete foundation in right foreground was from 'telltale,' a simple post-and-beam frame that spanned the tracks with lengths of rope suspended from the beam. In the days when brakemen were required to be on, and walk along, the tops of freight cars to set brakes, the 'telltale' ropes would strike the unwary to warn of the tunnel ahead, allowing them to lie flat and avoid being struck by the tunnel portal. - Central Pacific Transcontinental Railroad, Tunnel No. 23, Milepost 132.69, Applegate, Placer County, CA

  8. Video-assisted thoracoscopic thymectomy using 5-mm ports and carbon dioxide insufflation

    PubMed Central

    2016-01-01

    The continuous development and refinement of minimally invasive approaches to thymectomy over the last two decades has potential benefits for patients in terms of better cosmesis, less postoperative pain, shorter length of stay, earlier return to daily activities, less bleeding and fewer complications overall with similar outcomes regarding survival, recurrence of thymoma and complete remission (CR) for myasthenia gravis patients. A variety of different approaches have been described previously. This is a detailed description of video-assisted thoracoscopic thymectomy using three 5 mm ports, carbon dioxide (CO2) insufflation and bipolar electrocoagulation (LigaSure). PMID:26904432

  9. „Überholen ohne einzuholen“ Die Entwicklung von Technologien für übermorgen in Kernenergie und Mikroelektronik der DDR

    NASA Astrophysics Data System (ADS)

    Barkleit, Gerhard

    Dem nuklearen Patt zwischen Ostblock und westlichem Staatenbündnis ist es nach weitgehend übereinstimmender Auffassung von Politik und Wissenschaft zu danken, dass der "Kalte Krieg" in der zweiten Hälfte des 20. Jahrhunderts nicht zum weltumfassenden Flächenbrand eskalierte. An der raschen Herstellung dieses Patts waren zwei Dresdner Physiker maßgeblich beteiligt, deren einer im Manhattan-Projekt in den USA gearbeitet hatte und später in England der Spionage für die Sowjetunion und des Verrats des Know-how der Atombombe überführt wurde.

  10. Werk und Leben Walter Christallers . Auszüge aus der Festrede anläßlich der Verleihung des Walter-Christaller-Preises 1996

    NASA Astrophysics Data System (ADS)

    Hottes, Ruth

    1997-03-01

    Unter der Betreuung und Federführung von Robert Gradmann promovierte am Erlanger Geographischen Institut 1932 Walter Christaller mit seiner Dissertation `Die Zentralen Orte in Süddeutschland'. Diese mit summa cum laude bewertete Monographie sollte die vielleicht berühmteste geographische Doktorarbeit unseres Jahrhunderts werden. Sie hat in den vergangenen Jahrzehnten einen beispiellosen Siegeszug angetreten. Heute gilt sie für Geographie, Raumwirtschaftslehre, Stadtforschung und Standorttheorie als eine bahnbrechende Grundkonzeption, und sie ist von größter Bedeutung für Raumordnungspolitik und Planungspraxis."

  11. MM-1 facilitates degradation of c-Myc by recruiting proteasome and a novel ubiquitin E3 ligase.

    PubMed

    Kimura, Yumiko; Nagao, Arisa; Fujioka, Yuko; Satou, Akiko; Taira, Takahiro; Iguchi-Ariga, Sanae M M; Ariga, Hiroyoshi

    2007-10-01

    We have reported that a novel c-Myc-binding protein, MM-1, repressed the E-box-dependent transcription activity of c-Myc by recruiting the HDAC1 complex via TIF1beta/KAP1, a transcriptional corepressor. We have also reported that a mutation of A157R in MM-1, which is often observed in patients with leukemia or lymphoma, abrogated all of the repressive activities of MM-1 toward c-Myc, indicating that MM-1 is a novel tumor suppressor. In this study, we found that MM-1 was bound to a component of proteasome and stimulated degradation of c-Myc in human cells. Knockdown of endogenous MM-1 in human HeLa cells by introduction of siRNA against MM-1 stabilized the endogenous c-Myc. To identify proteins that participate in c-Myc degradation by MM-1, in vivo and in vitro binding assays were carried out. The results showed that MM-1 directly bound to Rpt3, a subunit of 26S proteasome, and that c-Myc directly bound to Skp2, which recruited ElonginC, ElonginB and Cullin2, thereby forming a novel ubiquitin E3 ligase. Knockdown of endogenous Cullin2 stabilized the endogenous c-Myc. Thus, MM-1 is a factor that connects c-Myc to the ubiquitin E3 ligase and the proteasome.

  12. Development of ultrahigh resolution Si-PM-based PET system using 0.32 mm pixel scintillators

    NASA Astrophysics Data System (ADS)

    Yamamoto, Seiichi; Watabe, Hiroshi; Watabe, Tadashi; Ikeda, Hayato; Kanai, Yasukazu; Ogata, Yoshimune; Kato, Katsuhiko; Hatazawa, Jun

    2016-11-01

    Ultrahigh resolution small animal PET systems require small pixel size scintillators. We developed an ultrahigh resolution small animal PET system using fine LYSO pixels, which were 0.32 mm×0.5 mm×5.0 mm. The LYSO pixels were combined into a 22×15 matrix with a 0.1 mm thick BaSO4 reflector between them. The LYSO block was 9.24 mm×9.0 mm×5 mm, and it was optically coupled to a 4×4 through silicon via silicon photomultiplier (TSV Si-PM) array that has smaller gaps between channels with a 1-mm thick light guide. We made eight Si-PM-based block detectors and arranged them octagonally to form a PET detector ring. At the center, the spatial resolution of the developed PET system, which was reconstructed by filtered back projection (FBP), was 0.6-mm FWHM. The sensitivity at the axial center was 0.5%. The peak noise equivalent count rate (NECR) was 12.5 k cps. We obtained high resolution images of phantoms and small animals with the developed PET system. With these results, we conclude that a high resolution PET system is possible with 0.32 mm pixel LYSO scintillators.

  13. MM-Estimator and Adjusted Super Smoother based Simultaneous Prediction Confedenc

    SciTech Connect

    Loguinov, Alexandre V.

    2002-07-19

    A Novel Application of Regression Analysis (MM-Estimator) with Simultaneous Prediction Confidence Intervals are proposed to detect up- or down-regulated genes, which are outliers in scatter plots based on log-transformed red (Cy5 fluorescent dye) versus green (Cy3 fluorescent Dye) intensities. Advantages of the application: 1) Robust and Resistant MM-Estimator is a Reliable Method to Build Linear Regression In the presence of Outliers, 2) Exploratory Data Analysis Tools (Boxplots, Averaged Shifted Histograms, Quantile-Quantile Normal Plots and Scatter Plots) are Unsed to Test Visually underlying assumptions of linearity and Contaminated Normality in Microarray data), 3) Simultaneous prediction confidence intervals (SPCIs) Guarantee a desired confidence level across the whole range of the data points used for the scatter plots. Results of the outlier detection procedure is a set of significantly differentially expressed genes extracted from the employed microarray data set. A scatter plot smoother (super smoother or locally weighted regression) is used to quantify heteroscendasticity is residual variance (Commonly takes place in lower and higher intensity areas). The set of differentially expressed genes is quantified using interval estimates for P-values as a probabilistic measure of being outlier by chance. Monte Carlo simultations are used to adjust super smoother-based SPCIs.her.

  14. 200-mm-diameter neutral beam source based on inductively coupled plasma etcher and silicon etching

    SciTech Connect

    Kubota, Tomohiro; Nukaga, Osamu; Ueki, Shinji; Sugiyama, Masakazu; Inamoto, Yoshimasa; Ohtake, Hiroto; Samukawa, Seiji

    2010-09-15

    The authors developed a neutral beam source consisting of a 200-mm-diameter inductively coupled plasma etcher and a graphite neutralization aperture plate based on the design of a neutral beam source that Samukawa et al. [Jpn. J. Appl. Phys., Part 2 40, L779 (2001)] developed. They measured flux and energy of neutral particles, ions, and photons using a silicon wafer with a thermocouple and a Faraday cup and calculated the neutralization efficiency. An Ar neutral beam flux of more than 1 mA/cm{sup 2} in equivalent current density and a neutralization efficiency of more than 99% were obtained. The spatial uniformity of the neutral beam flux was within {+-}6% within a 100 mm diameter. Silicon etching using a F{sub 2}-based neutral beam was done at an etch rate of about 47 nm/min, while Cl{sub 2}-based neutral beam realized completely no undercut. The uniformity of etch rate was less than {+-}5% within the area. The etch rate increased by applying bias power to the neutralization aperture plate, which shows that accelerated neutral beam was successfully obtained. These results indicate that the neutral beam source is scalable, making it possible to obtain a large-diameter and uniform neutral beam, which is inevitable for application to mass production.

  15. Improved QM Methods and Their Application in QM/MM Studies of Enzymatic Reactions

    NASA Astrophysics Data System (ADS)

    Jorgensen, William L.

    2007-03-01

    Quantum mechanics (QM) and Monte Carlo statistical mechanics (MC) simulations have been used by us since the early 1980s to study reaction mechanisms and the origin of solvent effects on reaction rates. A goal was always to perform the QM and MC/MM calculations simultaneously in order to obtain free-energy surfaces in solution with no geometrical restrictions. This was achieved by 2002 and complete free-energy profiles and surfaces with full sampling of solute and solvent coordinates can now be obtained through one job submission using BOSS [JCC 2005, 26, 1689]. Speed and accuracy demands also led to development of the improved semiempirical QM method, PDDG-PM3 [JCC 1601 (2002); JCTC 817 (2005)]. The combined PDDG-PM3/MC/FEP methodology has provided excellent results for free energies of activation for many reactions in numerous solvents. Recent examples include Cope, Kemp and E1cb eliminations [JACS 8829 (2005), 6141 (2006); JOC 4896 (2006)], as well as enzymatic reactions catalyzed by the putative Diels-Alderase, macrophomate synthase, and fatty-acid amide hydrolase [JACS 3577 (2005); JACS (2006)]. The presentation will focus on the accuracy that is currently achievable in such QM/MM studies and the accuracy of the underlying QM methodology including extensive comparisons of results from PDDG-PM3 and ab initio DFT methods.

  16. Mm-size bistable zipping dielectric elastomer actuators for integrated microfluidics

    NASA Astrophysics Data System (ADS)

    Maffli, Luc; Rosset, Samuel; Shea, Herbert R.

    2013-04-01

    We report on a new structure of Dielectric Elastomer Actuators (DEAs) called zipping DEAs, which have a set of unique characteristics that are a good match for the requirements of electrically-powered integrated microfluidic pumping and/or valving units as well as Braille displays. The zipping DEAs operate by pulling electrostatically an elastomer membrane in contact with the rigid sidewalls of a sloped chamber. In this work, we report on fully functional mm-size zipping DEAs that demonstrate a complete sealing of the chamber sidewalls and a tunable bistable behavior, and compare the measurements with an analytical model. Compared to our first generation of devices, we are able vary the sidewall angle and benefit therefore from more flexibility to study the requirements to make fully functional actuators. In particular, we show that with Nusil CF19 as membrane material (1.2 MPa Young's modulus), it is possible to zip completely 2.3 mm diameter chambers with 15° and 21° sidewalls angle equibiaxially prestretched to λ0=1.12 and 15° chambers with λ0=1.27.

  17. Experimental analysis of 7.62 mm hydrodynamic ram in containers

    NASA Astrophysics Data System (ADS)

    Deletombe, E.; Fabis, J.; Dupas, J.; Mortier, J. M.

    2013-02-01

    The design of fuel tanks with a reduced vulnerability with respect to hydrodynamic ram pressure (HRAM) effects is of an increasing need in the Civil (e.g. the Concorde accident), and Defence (military aircraft, unmanned vehicle systems) aircraft industries. The presented work concerns experimental research which aims at observing two hydraulic ram events - both induced by a 7.62 mm bullet shot in very different containers - throughout their various steps until the final collapse of the generated cavity, in order to study the nature of HRAM, the influence of the containers geometry, and to measure original dynamic data for numerical modelling developments and validation. For that purpose, test configurations and experimental results are described, documented and discussed. They concern two types of firing tests that were performed at ONERA using the NATO 7.62 mm projectile, respectively in the frame of ONERA (pool) and EUCLID (caisson) funded research projects. The authors concentrate on two topics: on the one hand, digital image analysis to measure the cavity geometry during its growth and collapse phases and, on the other hand, pressure measurements that catch the transient shock wave. The originality of the work consists in the fact that - compared with other published works - the phenomenon is studied up to tens of milliseconds in a very large pool for theoretical analysis of the bullet/liquid interactions only, and in a realistic fuel tank specimen to consider influence of boundary conditions onto the cavity characteristics (geometry, dynamics).

  18. Nanofibrous nerve conduits for repair of 30-mm-long sciatic nerve defects

    PubMed Central

    Biazar, Esmaeil; Keshel, Saeed Heidari; Pouya, Majid; Rad, Hadi; Nava, Melody Omrani; Azarbakhsh, Mohammad; Hooshmand, Shirin

    2013-01-01

    It has been confirmed that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit can promote peripheral nerve regeneration in rats. However, its efficiency in repair of over 30-mm-long sciatic nerve defects needs to be assessed. In this study, we used a nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit to bridge a 30-mm-long gap in the rat sciatic nerve. At 4 months after nerve conduit implantation, regenerated nerves were cally observed and histologically assessed. In the nanofibrous graft, the rat sciatic nerve trunk had been reconstructed by restoration of nerve continuity and formation of myelinated nerve fiber. There were Schwann cells and glial cells in the regenerated nerves. Masson's trichrome staining showed that there were no pathological changes in the size and structure of gastrocnemius muscle cells on the operated side of rats. These findings suggest that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit is suitable for repair of long-segment sciatic nerve defects. PMID:25206536

  19. Molecules in Sagittarius B2: a line study of the whole 7-mm band with CABB

    NASA Astrophysics Data System (ADS)

    Jones, Paul; Lo, Nadia; Cunningham, Maria; Thorwirth, Sven; Menten, Karl; Schilke, Peter; Belloche, Arnaud; Mueller, Holger S. P.; Walsh, Andrew; Bronfman, Leonardo; Purcell, Cormac; Cordiner, Martin; Remijan, Anthony; Charnley, Steven; Qin, Sheng-Li; Balnozan, Egon

    2013-04-01

    We wish to survey the whole 7-mm band toward the pre-eminent molecular line source in the Galaxy, the Sagittarius B2 (N) Large Molecule Heimat, using the CABB on the ATCA. This is a follow-up program to the Green Bank Telescope (GBT) PRebiotic Interstellar MOlecule Survey (PRIMOS) which is surveying Sgr B2(N-LMH) over the whole frequency range accessible to the GBT. This project also complements ALMA 3-mm observations recently accepted for cycle 1. Complementary single dish and interferometer observations are essential to the understanding of the chemistry of the interstellar medium (ISM), and the ATCA has the spatial resolution to allow us to investigate the variations in the ISM chemistry at small spatial scales to compare with the extended distributions to which the single dish is sensitive. With the CABB, the ATCA now has the bandwidth to make the necessary broad band studies feasible. We were granted 8 hours in the 2011OctS round, and request a further 20 hours this round to extend the frequency coverage.

  20. FT-Raman and QM/MM study of the interaction between histamine and DNA

    NASA Astrophysics Data System (ADS)

    Ruiz-Chica, A. J.; Soriano, A.; Tuñón, I.; Sánchez-Jiménez, F. M.; Silla, E.; Ramírez, F. J.

    2006-05-01

    The interaction between histamine and highly polymerized calf-thymus DNA has been investigated using FT-Raman spectroscopy and the hybrid QM/MM (quantum mechanics/molecular mechanics) methodology. Raman spectra of solutions containing histamine and calf-thymus DNA, at different molar ratios, were recorded. Solutions were prepared at physiological settings of pH and ionic strength, using both natural and heavy water as the solvent. The analysis of the spectral changes on the DNA Raman spectra when adding different concentrations of histamine allowed us to identify the reactive sites of DNA and histamine, which were used to built two minor groove and one intercalated binding models. They were further used as starting points of the QM/MM theoretical study. However, minimal energy points were only reached for the two minor groove models. For each optimized structure, we calculated analytical force constants of histamine molecule in order to perform the vibrational dynamics. Normal mode descriptions allowed us to compare calculated wavenumbers for DNA-interacting histamine to those measured in the Raman spectra of DNA-histamine solutions.

  1. SiGe BiCMOS manufacturing platform for mmWave applications

    NASA Astrophysics Data System (ADS)

    Kar-Roy, Arjun; Howard, David; Preisler, Edward; Racanelli, Marco; Chaudhry, Samir; Blaschke, Volker

    2010-10-01

    TowerJazz offers high volume manufacturable commercial SiGe BiCMOS technology platforms to address the mmWave market. In this paper, first, the SiGe BiCMOS process technology platforms such as SBC18 and SBC13 are described. These manufacturing platforms integrate 200 GHz fT/fMAX SiGe NPN with deep trench isolation into 0.18μm and 0.13μm node CMOS processes along with high density 5.6fF/μm2 stacked MIM capacitors, high value polysilicon resistors, high-Q metal resistors, lateral PNP transistors, and triple well isolation using deep n-well for mixed-signal integration, and, multiple varactors and compact high-Q inductors for RF needs. Second, design enablement tools that maximize performance and lowers costs and time to market such as scalable PSP and HICUM models, statistical and Xsigma models, reliability modeling tools, process control model tools, inductor toolbox and transmission line models are described. Finally, demonstrations in silicon for mmWave applications in the areas of optical networking, mobile broadband, phased array radar, collision avoidance radar and W-band imaging are listed.

  2. Design and fabrication of sub-mm-sized modules containing encapsulated cells for modular tissue engineering.

    PubMed

    McGuigan, Alison P; Sefton, Michael V

    2007-05-01

    We have proposed modular tissue engineering as a strategy to construct vascularized tissues containing multiple cell types. To create a modular construct, instead of seeding a preformed scaffold, cells were encapsulated within sub-mm modules, and the outer surface of these modules was covered with a layer of endothelial cells. Modules were then added to a larger structure (here by filling a tube) to form the modular construct. Through a systematic process of materials selection, collagen, human umbilical vein endothelial cells (HUVECs), and HepG2 cells, a human hepatoma cell line, were identified as suitable components for module formation, at least for initial studies. A method, which involved cutting and shaping the modules within a tubular mold, was developed to fabricate sub-mm, cylindrical, collagen modules that contained viable, functioning HepG2 cells and that could be seeded with a surface layer of HUVECs. Module dimensions were reproducible and easily altered in a controlled fashion if desired. The module fabrication process developed here not only generated modules suitable for the assembly of a prototype modular construct, but also could potentially be used more generally for other applications for which the goal is to form submm-diameter cylinders from soft hydrogels.

  3. Diplosphaera sp. MM1 - A microalga with phycoremediation and biomethane potential.

    PubMed

    Liu, Cuixia; Subashchandrabose, Suresh R; Megharaj, Mallavarapu; Hu, Zhiquan; Xiao, Bo

    2016-10-01

    This study evaluated the potential of a microalga Diplosphaera sp. MM1 for its ability to generate energy through biomass production from wastewater remediation. 33% dairy wastewater and 50% winery wastewater demonstrated as promising alternative media for cultivating Diplosphaera sp. MM1 biomass. Interestingly, the alga cultivated in 50% winery wastewater with limited nitrogen produced the highest lipid content (43.07% total solid) and the lowest carbohydrate content (9.35% TS). On the contrary, the lowest lipid content (16.98% TS) and the highest carbohydrate content (29.39% TS) were exhibited by the alga cultivated in 33% dairy wastewater. The results from anaerobic digestion processes in terms of biochemical methane potential of the alga cultivated in BG-11 medium, 33% dairy wastewater and 50% winery wastewater were 197.39, 129.75 and 218.51NmLg(-1)VS, respectively. Further, this study demonstrates the potential of winery wastewater as a candidate to increase the lipid content of algae and enhance biofuel production of algal biomass.

  4. Stochastic properties of the geomagnetic field across the 210 mm chain

    NASA Astrophysics Data System (ADS)

    Wanliss, J. A.; Shiokawa, K.; Yumoto, K.

    2013-12-01

    We explore the stochastic fractal qualities of the geomagnetic field from 210 mm ground-based magnetometers during quiet and active magnetospheric conditions. We search through 10 years of these data to find events that qualify. Quiet intervals are defined by Kp ≤ 1 for 1,440 consecutive minutes. Similarly, active intervals require Kp ≥ 4 for 1,440 consecutive minutes. The total for quiet intervals is ~4.3×106 minutes and 2×108 minutes for active data points. With this large number of events compiled we then characterize changes in the nonlinear statistics of the geomagnetic field via measurements of a fractal scaling exponent. A clear difference in statistical behavior during quiet and active intervals is implied through analysis of the scaling exponents; active intervals generally have larger values of scaling exponents. This means that although 210 mm data appears monofractal on shorter timescales, it is more properly described as a multifractional Brownian motion. Long-range statistical behavior of the geomagnetic field at a local observation site can be described as a multifractional Brownian motion, thus suggesting the statistical structure required of mathematical models of magnetospheric activity. We also find that low-latitudes have scaling exponents that are consistently larger than for high-latitudes.

  5. Fabrication and Analysis of 150-mm-Aperture Nb3Sn MQXF Coils

    DOE PAGES

    Holik, E. F.; Ambrosio, G.; Anerella, M.; ...

    2016-01-12

    The U.S. LHC Accelerator Research Program (LARP) and CERN are combining efforts for the HiLumi-LHC upgrade to design and fabricate 150-mm-aperture, interaction region quadrupoles with a nominal gradient of 130 T/m using Nb3Sn. To successfully produce the necessary long MQXF triplets, the HiLumi-LHC collaboration is systematically reducing risk and design modification by heavily relying upon the experience gained from the successful 120-mm-aperture LARP HQ program. First generation MQXF short (MQXFS) coils were predominately a scaling up of the HQ quadrupole design allowing comparable cable expansion during Nb3Sn formation heat treatment and increased insulation fraction for electrical robustness. A total ofmore » 13 first generation MQXFS coils were fabricated between LARP and CERN. Systematic differences in coil size, coil alignment symmetry, and coil length contraction during heat treatment are observed and likely due to slight variances in tooling and insulation/cable systems. Analysis of coil cross sections indicate that field-shaping wedges and adjacent coil turns are systematically displaced from the nominal location and the cable is expanding less than nominally designed. Lastly, a second generation MQXF coil design seeks to correct the expansion and displacement discrepancies by increasing insulation and adding adjustable shims at the coil pole and midplanes to correct allowed magnetic field harmonics.« less

  6. Fine Scale Structure of AGN Jets with 1.3 mm VLBI

    NASA Astrophysics Data System (ADS)

    Lu, Rusen; Fish, V. L.; Weintroub, J.; Doeleman, S.; Bower, G. C.; Freund, R.; Friberg, P.; Ho, P. T.; Honma, M.; Inoue, M.; Jorstad, S. G.; Krichbaum, T.; Marrone, D. P.; Marscher, A. P.; Moran, J. M.; Oyama, T.; Plambeck, R. L.; Primiani, R.; Shen, Z.; Tilanus, R.; Wright, M.; Young, K.; Ziurys, L. M.; Zensus, A.

    2013-01-01

    We report results from 1.3 mm VLBI observations of AGN jets with the Event Horizon Telescope focusing on the southern blazar 1921-293. We show the first 1.3 mm VLBI model image of 1921-293 using closure phase techniques obtained with four telescopes at three observatories: the James Clerk Maxwell Telescope (JCMT) on Mauna Kea in Hawaii, the Arizona Radio Observatory's Submillimeter Telescope (SMT) in Arizona, and two telescopes of the Combined Array for Research in Millimeterwave Astronomy (CARMA) in California in April 2009. With the greatly improved resolution compared with previous observations and robust closure phase measurement, the inner jet structure of 1921-293 was spatially resolved. The inner jet extends to the northwest along a position angle of -53° degree at a distance of 0.38 mas from the tentatively identified core, in agreement with the inner jet structure inferred from lower frequencies, and making a position angle difference of ~80° with respect to the cm-jet. The size of the compact core is 0.15 pc with a brightness temperature of 1.2 ×1011 K. Compared with those measured at lower frequencies, the low brightness temperature may argue in favor of the decelerating jet model or particle-cascade models. Some results for another blazar 3C 279 will also be presented.

  7. Real-time image processing for passive mmW imagery

    NASA Astrophysics Data System (ADS)

    Kozacik, Stephen; Paolini, Aaron; Bonnett, James; Harrity, Charles; Mackrides, Daniel; Dillon, Thomas E.; Martin, Richard D.; Schuetz, Christopher A.; Kelmelis, Eric; Prather, Dennis W.

    2015-05-01

    The transmission characteristics of millimeter waves (mmWs) make them suitable for many applications in defense and security, from airport preflight scanning to penetrating degraded visual environments such as brownout or heavy fog. While the cold sky provides sufficient illumination for these images to be taken passively in outdoor scenarios, this utility comes at a cost; the diffraction limit of the longer wavelengths involved leads to lower resolution imagery compared to the visible or IR regimes, and the low power levels inherent to passive imagery allow the data to be more easily degraded by noise. Recent techniques leveraging optical upconversion have shown significant promise, but are still subject to fundamental limits in resolution and signal-to-noise ratio. To address these issues we have applied techniques developed for visible and IR imagery to decrease noise and increase resolution in mmW imagery. We have developed these techniques into fieldable software, making use of GPU platforms for real-time operation of computationally complex image processing algorithms. We present data from a passive, 77 GHz, distributed aperture, video-rate imaging platform captured during field tests at full video rate. These videos demonstrate the increase in situational awareness that can be gained through applying computational techniques in real-time without needing changes in detection hardware.

  8. Fabrication of 200 mm Diameter Sintering Body of Skutterudite Thermoelectric Material by Spark Plasma Sintering

    NASA Astrophysics Data System (ADS)

    Tomida, T.; Sumiyoshi, A.; Nie, G.; Ochi, T.; Suzuki, S.; Kikuchi, M.; Mukaiyama, K.; Guo, J. Q.

    2016-11-01

    Filled skutterudite is a promising material for thermoelectric power generation because its ZT value is relatively high. However, mass production of high-performance thermoelectric materials remains a challenge. This study focused on the sintering process of thermoelectric materials. Large-diameter n-type (Yb or La, Ca, Al, Ga, In)0.8(Co, Fe)4Sb12 skutterudite sintering bodies with a small thickness were successfully produced by the spark plasma sintering (SPS) method. When direct current flows through the thermoelectric sintering body during the SPS pulse, the Peltier effect causes a temperature difference within the sintering body. To eliminate the Peltier effect, an electrical insulating material was inserted between the punch (electrode) and the sintering body. In this way, an n-type La-filled skutterudite sample with a diameter of 200 mm, thickness of 21 mm, and weight of 5 kg was successfully produced. The thermoelectric properties and microstructures of the sample were almost the same throughout the whole sintering body, and the dimensionless figure of merit reached 1.0 at 773 K.

  9. Quantum and Molecular Mechanical (QM/MM) Monte Carlo Techniques for Modeling Condensed-Phase Reactions

    PubMed Central

    Jorgensen, Wiliiam L.

    2014-01-01

    A recent review (Acc. Chem. Res. 2010, 43:142–151) examined our use and development of a combined quantum and molecular mechanical (QM/MM) technique for modelling organic and enzymatic reactions. Advances included the PDDG/PM3 semiempirical QM (SQM) method, computation of multi-dimensional potentials of mean force (PMF), incorporation of on-the-fly QM in Monte Carlo simulations, and a polynomial quadrature method for rapidly treating proton-transfer reactions. The current article serves as a follow up on our progress. Highlights include new reactions, alternative SQM methods, a polarizable OPLS force field, and novel solvent environments, e.g., “on water” and room temperature ionic liquids. The methodology is strikingly accurate across a wide range of condensed-phase and antibody-catalyzed reactions including substitution, decarboxylation, elimination, isomerization, and pericyclic classes. Comparisons are made to systems treated with continuum-based solvents and ab initio or density functional theory (DFT) methods. Overall, the QM/MM methodology provides detailed characterization of reaction paths, proper configurational sampling, several advantages over implicit solvent models, and a reasonable computational cost. PMID:25431625

  10. 3D Imaging with a Single-Aperture 3-mm Objective Lens: Concept, Fabrication and Test

    NASA Technical Reports Server (NTRS)

    Korniski, Ron; Bae, Sam Y.; Shearn, Mike; Manohara, Harish; Shahinian, Hrayr

    2011-01-01

    There are many advantages to minimally invasive surgery (MIS). An endoscope is the optical system of choice by the surgeon for MIS. The smaller the incision or opening made to perform the surgery, the smaller the optical system needed. For minimally invasive neurological and skull base surgeries the openings are typically 10-mm in diameter (dime sized) or less. The largest outside diameter (OD) endoscope used is 4mm. A significant drawback to endoscopic MIS is that it only provides a monocular view of the surgical site thereby lacking depth information for the surgeon. A stereo view would provide the surgeon instantaneous depth information of the surroundings within the field of view, a significant advantage especially during brain surgery. Providing 3D imaging in an endoscopic objective lens system presents significant challenges because of the tight packaging constraints. This paper presents a promising new technique for endoscopic 3D imaging that uses a single lens system with complementary multi-bandpass filters (CMBFs), and describes the proof-of-concept demonstrations performed to date validating the technique. These demonstrations of the technique have utilized many commercial off-the-shelf (COTS) components including the ones used in the endoscope objective.

  11. Design of a 2-mm Wavelength KIDs Prototype Camera for the Large Millimeter Telescope

    NASA Astrophysics Data System (ADS)

    Velázquez, M.; Ferrusca, D.; Castillo-Dominguez, E.; Ibarra-Medel, E.; Ventura, S.; Gómez-Rivera, V.; Hughes, D.; Aretxaga, I.; Grant, W.; Doyle, S.; Mauskopf, P.

    2016-08-01

    A new camera is being developed for the Large Millimeter Telescope (Sierra Negra, México) by an international collaboration with the University of Massachusetts, the University of Cardiff, and Arizona State University. The camera is based on kinetic inductance detectors (KIDs), a very promising technology due to their sensitivity and especially, their compatibility with frequency domain multiplexing at microwave frequencies allowing large format arrays, in comparison with other detection technologies for mm-wavelength astronomy. The instrument will have a 100 pixels array of KIDs to image the 2-mm wavelength band and is designed for closed cycle operation using a pulse tube cryocooler along with a three-stage sub-kelvin 3He cooler to provide a 250 mK detector stage. RF cabling is used to readout the detectors from room temperature to 250 mK focal plane, and the amplification stage is achieved with a low-noise amplifier operating at 4 K. The readout electronics will be based on open-source reconfigurable open architecture computing hardware in order to perform real-time microwave transmission measurements and monitoring the resonance frequency of each detector, as well as the detection process.

  12. QM/MM Simulation on P450 BM3 Enzyme Catalysis Mechanism

    PubMed Central

    Tian, Li; Friesner, Richard A.

    2009-01-01

    Using a structure generated by induced fit modeling of the protein-ligand complex, the reaction path for hydrogen atom abstraction in P450 BM3 is studied by means of mixed QM/MM methods to determine the structures and energetics along the reaction path. The IFD structure is suitable for hydrogen atom abstraction at the ω-1 position. The electronic structures obtained are similar to those observed in P450 cam. We show that the barrier for the hydrogen abstraction step from QM/MM modeling is 13.3 kcal/mol in quartet and 15.6 kcal/mol in doublet. Although there is some strain energy present in the ligand, the activation barrier is not dramatically affected. A crystal water molecule, HOH502, plays a role as catalyst and decreases the activation barrier by about 2 kcal/mol and reaction energy by about 3-4 kcal/mol. In order to achieve reactive chemistry at the remaining experimentally observed positions in the hydrocarbon tail of the ligand, other structures would have to be utilized as a starting point for the reaction. Finally, the present results still leave open the question of whether DFT methods provide an accurate computation of the barrier height in the P450 hydrogen atom abstraction reaction. PMID:20046929

  13. 50 mm Diameter digital DC/pulse neutron generator for subcritical reactor test

    NASA Astrophysics Data System (ADS)

    Li, Gang; Zhang, Zhong-Shuai; Chi, Qian; Liu, Lin-Mao

    2012-11-01

    A 50 mm diameter digital DC/pulse neutron generator was developed with 25 mm ceramic drive-in target neutron tube. It was applied in the subcritical reactor test of China Institute of Atomic Energy (CIAE). The generator can produce neutron in three modes: DC, pulse and multiple pulse. The maximum neutron yield of the generator is 1 × 108 n/s, while the maximum pulse frequency is 10 kHz, and the minimum pulse width is 10 μs. As a remote controlled generator, it is small in volume, easy to be connected and controlled. The tested results indicate that penning ion source has the feature of delay time in glow discharge, and it is easier for glow discharge to happen when switching the DC voltage of penning ion source into pulse. According to these two characteristics, the generator has been modified. This improved generator can be used in many other areas including Prompt Gamma Neutron Activation Analysis (PGNAA), neutron testing and experiment.

  14. Improved Sugar Puckering Profiles for Nicotinamide Ribonucleoside for Hybrid QM/MM Simulations.

    PubMed

    Pshetitsky, Yaron; Eitan, Reuven; Verner, Gilit; Kohen, Amnon; Major, Dan Thomas

    2016-10-11

    The coenzyme nicotinamide adenine dinucleotide (NAD(+)) and its reduced form (NADH) play ubiquitous roles as oxidizing and reducing agents in nature. The binding, and possibly the chemical redox step, of NAD(+)/NADH may be influenced by the cofactor conformational distribution and, in particular, by the ribose puckering of its nicotinamide-ribonucleoside (NR) moiety. In many hybrid quantum mechanics-molecular mechanics (QM/MM) studies of NAD(+)/NADH dependent enzymes, the QM region is treated by semiempirical (SE) methods. Recent work suggests that SE methods do not adequately describe the ring puckering in sugar molecules. In the present work we adopt an efficient and practical strategy to correct for this deficiency for NAD(+)/NADH. We have implemented a cost-effective correction to a SE Hamiltonian by adding a correction potential, which is defined as the difference between an accurate benchmark density functional theory (DFT) potential energy surface (PES) and the SE PES. In practice, this is implemented via a B-spline interpolation scheme for the grid-based potential energy difference surface. We find that the puckering population distributions obtained from free energy QM(SE)/MM simulations are in good agreement with DFT and in fair accord with experimental results. The corrected PES should facilitate a more accurate description of the ribose puckering in the NAD(+)/NADH cofactor in simulations of biological systems.

  15. The Intrinsic Shape of Sagittarius A* at 3.5 mm Wavelength

    NASA Astrophysics Data System (ADS)

    Ortiz-León, Gisela N.; Johnson, Michael D.; Doeleman, Sheperd S.; Blackburn, Lindy; Fish, Vincent L.; Loinard, Laurent; Reid, Mark J.; Castillo, Edgar; Chael, Andrew A.; Hernández-Gómez, Antonio; Hughes, David H.; León-Tavares, Jonathan; Lu, Ru-Sen; Montaña, Alfredo; Narayanan, Gopal; Rosenfeld, Katherine; Sánchez, David; Schloerb, F. Peter; Shen, Zhi-qiang; Shiokawa, Hotaka; SooHoo, Jason; Vertatschitsch, Laura

    2016-06-01

    The radio emission from Sgr A{}\\ast is thought to be powered by accretion onto a supermassive black hole of ˜ 4× {10}6 {M}⊙ at the Galactic Center. At millimeter wavelengths, Very Long Baseline Interferometry (VLBI) observations can directly resolve the bright innermost accretion region of Sgr A{}\\ast . Motivated by the addition of many sensitive long baselines in the north-south direction, we developed a full VLBI capability at the Large Millimeter Telescope Alfonso Serrano (LMT). We successfully detected Sgr A{}\\ast at 3.5 mm with an array consisting of six Very Long Baseline Array telescopes and the LMT. We model the source as an elliptical Gaussian brightness distribution and estimate the scattered size and orientation of the source from closure amplitude and self-calibration analysis, obtaining consistent results between methods and epochs. We then use the known scattering kernel to determine the intrinsic two-dimensional source size at 3.5 mm: (147+/- 7 μ {{as}})× (120+/- 12 μ {{as}}), at position angle 88^\\circ +/- 7^\\circ east of north. Finally, we detect non-zero closure phases on some baseline triangles, but we show that these are consistent with being introduced by refractive scattering in the interstellar medium and do not require intrinsic source asymmetry to explain.

  16. A pilot search for mm-RRLs in pre-Planetary Nebulae

    NASA Astrophysics Data System (ADS)

    Sánchez Contreras, C.; Báez-Rubio, A.; Alcolea, J.; Bujarrabal, V.; Martín-Pintado, J.

    2017-03-01

    We carried out pilot search for radio recombination line (RRL) emission at millimeter wavelengths in a small sample of pre-Planetary Nebulae (pPNe) and young PNe (yPNe) with emerging central ionized winds. RRLs at mm-wavelengths are excellent probes of the dense inner (<150 au) regions of these objects, where the yet unknown agents for PN-shaping operate, and which are usually heavily obscured at shorter wavelengths by optically thick circumstellar dust shells. We detect mm-RRLs in three objects: CRL 618, MWC 922, and M 2-9. We present the results from detailed line + continuum non-LTE 3D radiative transfer models for these targets, which enables constraning the structure, kinematics, and physical conditions (electron temperature and density) of their ionized cores. Amongst other parameters, we derive mass-loss rates of M_{pAGB} ≈ 10^{-6} - 10^{-7} M_{⊙} yr^{-1}, which are significantly higher than the values adopted by stellar evolution models currently in use.

  17. Validation of climate-mode MM5-simulations for the European Alpine Region

    NASA Astrophysics Data System (ADS)

    Pfeiffer, Andreas; Zängl, Günther

    2010-07-01

    Climate mode simulations using MM5 have been conducted over Western Europe on a 45-km grid driven by ECMWF’s ERA40 reanalysis data. We focus our validation on the Alpine region and the Alpine foreland. A reference experiment comprising the years of 1991 to 2000 shows reasonable correspondence to station measurements and a gridded precipitation climatology of the Alps. Also, the mean monthly diurnal cycle of near-surface temperature and dew point temperature verified in the Alpine foreland compares quite well to station data showing some minor discrepancies mainly in the afternoon that seem to be common to regional models. Furthermore, a set of sensitivity experiments was conducted for the years of 1996 to 1999. This set was spanned on the one hand by three convection schemes to get an estimate of the possible range of simulated precipitation amounts inherent to the MM5-system. On the other hand, two different formulations of the horizontal numerical diffusion were investigated with respect to their influence on simulated precipitation in mountainous terrain. It was found that the impact of the formulation of numerical diffusion is similarly large as the sensitivity to the convection scheme, with computing diffusion along the terrain-following coordinate surfaces being clearly worse than computing it in a truly horizontal manner.

  18. In vitro biomechanical comparison of six different fixation methods following 5-mm sagittal split advancement osteotomies.

    PubMed

    Oguz, Y; Watanabe, E R; Reis, J M; Spin-Neto, R; Gabrielli, M A; Pereira-Filho, V A

    2015-08-01

    The sagittal split ramus osteotomy (SSRO) is a surgical technique used widely to treat many congenital and acquired mandibular discrepancies. Stabilization of the osteotomy site and the potential for skeletal relapse after the procedure are still major problems. The aim of this study was to compare the mechanical stability of six methods of rigid fixation in SSRO using a biomechanical test model. Sixty polyurethane replicas of human hemimandibles were divided into six groups. In group I, the osteotomies were fixed with two four-hole titanium miniplates; in group II, with one four-hole miniplate; in group III, with one four-hole miniplate+a bicortical screw; in group IV, with a grid miniplate; in group V, with a four-hole locking miniplate; and in group VI, with a six-hole miniplate. A linear load in the premolar region was applied to the hemimandibles. The resistance forces (N) needed to displace the distal segment by 1, 3, and 5mm were recorded and the data transmitted from the load cell to a computer. One-way analysis of variance with Tukey's post hoc test was performed to compare the means between groups. For the three displacement conditions, there was a strong tendency for the 2.0-mm plate+screw and the grid plate to have higher values.

  19. Lunar Brightness Variations with Phase at 4.3-MM Wave Length

    NASA Technical Reports Server (NTRS)

    Coates, Robert J.

    1961-01-01

    The lunar radio observations and interpretations of Piddington and Minnett (1949) and Gibson (1958) show that the lunar brightness variation with phase at millimeter wave lengths can be used to determine the physical properties of the lunar surface. They found that the millimeter-wave brightness lagged the optical phase, and their interpretation was that the millimeter radiation originates below a surface layer that is a very good thermal insulator. The thickness of this layer could not be determined from observations at one frequency. Observations at different frequencies give different results because of the wave-length dependence of the radio absorption by the surface material. The attenuation in the material increases with decreasing wave length, and therefore it is possible, in principle, to determine surface layer thickness from radio observations at several wave lengths. For this reason, observations of lunar radiation were started at the Naval Research Laboratory at a wave length of 4.3 mm. This is half the wave length used by Gibson (1958) in his earlier studies. The radio telescope used for these observations has been described in detail in a previous publication (Coates 1958). The antenna is a parabolic reflector 10 feet in diameter, and it has a beam width of 6.7 minutes of arc at the wave length of 4.3 mm. This is about one-fifth the diameter of the moon. The receiver was a Dicke-type radiometer.

  20. Evaluation of the propellant residues emitted during 105-mm Leopard tank live firing at CFB Valcartier, Canada

    DTIC Science & Technology

    2009-12-01

    layer 2.5-cm below the surface. The muzzle blast from the Leopard tank’s 105-mm rifled gun was ferocious, churning up and moving the snow in the first...Evaluation of the propellant residues emitted during 105-mm Leopard tank live firing at CFB Valcartier, Canada Guy Ampleman, Sonia Thiboutot, André...420 December 2009 Evaluation of the propellant residues emitted during 105-mm Leopard tank live firing at CFB Valcartier, Canada Guy Ampleman, Sonia