Space systems engineering and risk management - joined at the hip

NASA Technical Reports Server (NTRS)

Rose, James R.

2004-01-01

This paper explores the separate skills and capabilities practiced until now, and the powerful coupling to be achieved, practically and effectively, in implementing a space mission, from inception (pre-phase A) to the end of Operations (phase E). The use of risk assessment techniques in balancing cost risk against performance risk, and the application of the systems engineering team in these trades, is the key to achieving this new implementation paradigm.

A physics based multiscale modeling of cavitating flows.

PubMed

Ma, Jingsen; Hsiao, Chao-Tsung; Chahine, Georges L

2017-03-02

Numerical modeling of cavitating bubbly flows is challenging due to the wide range of characteristic lengths of the physics at play: from micrometers (e.g., bubble nuclei radius) to meters (e.g., propeller diameter or sheet cavity length). To address this, we present here a multiscale approach which integrates a Discrete Singularities Model (DSM) for dispersed microbubbles and a two-phase Navier Stokes solver for the bubbly medium, which includes a level set approach to describe large cavities or gaseous pockets. Inter-scale schemes are used to smoothly bridge the two transitioning subgrid DSM bubbles into larger discretized cavities. This approach is demonstrated on several problems including cavitation inception and vapor core formation in a vortex flow, sheet-to-cloud cavitation over a hydrofoil, cavitation behind a blunt body, and cavitation on a propeller. These examples highlight the capabilities of the developed multiscale model in simulating various form of cavitation.

A physics based multiscale modeling of cavitating flows

PubMed Central

Ma, Jingsen; Hsiao, Chao-Tsung; Chahine, Georges L.

2018-01-01

Numerical modeling of cavitating bubbly flows is challenging due to the wide range of characteristic lengths of the physics at play: from micrometers (e.g., bubble nuclei radius) to meters (e.g., propeller diameter or sheet cavity length). To address this, we present here a multiscale approach which integrates a Discrete Singularities Model (DSM) for dispersed microbubbles and a two-phase Navier Stokes solver for the bubbly medium, which includes a level set approach to describe large cavities or gaseous pockets. Inter-scale schemes are used to smoothly bridge the two transitioning subgrid DSM bubbles into larger discretized cavities. This approach is demonstrated on several problems including cavitation inception and vapor core formation in a vortex flow, sheet-to-cloud cavitation over a hydrofoil, cavitation behind a blunt body, and cavitation on a propeller. These examples highlight the capabilities of the developed multiscale model in simulating various form of cavitation. PMID:29720773

Scientific management of Space Telescope

NASA Technical Reports Server (NTRS)

Odell, C. R.

1981-01-01

A historical summay is given on the science management of the Space Telescope, the inception of which began in 1962, when scientists and engineers first recommended the development of a nearly diffraction limited substantial-size optical telescope. Phase A, the feasibility requirements generation phase, began in 1971 and consisted largely of NASA scientists and a NASA design. Phase B, the preliminary design phase, established a tiered structure of scientists, led by the Large Space Telescope operations and Management Work Group. A Mission Operations Working Group headed six instrument definition teams to develop the essential instrument definitions. Many changes took place during Phase B, before design and development, which began in 1978 and still continues today.

An experimental-computational analysis of MHV cavitation: effects of leaflet squeezing and rebound.

PubMed

Makhijani, V B; Yang, H Q; Singhal, A K; Hwang, N H

1994-04-01

A combined experimental-computational study was performed to investigate the flow mechanics which could cause cavitation during the squeezing and rebounding phases of valve closure in the 29 mm mitral bileaflet Edwards-Duromedics (ED) mechanical heart valve (MHV). Leaflet closing motion was measured in vitro, and input into a computational fluid mechanics software package, CFD-ACE, to compute flow velocities and pressures in the small gap space between the occluder tip and valve housing. The possibility of cavitation inception was predicted when fluid pressures dropped below the saturated vapor pressure for blood plasma. The computational analysis indicated that cavitation is more likely to be induced during valve rebound rather than the squeezing phase of valve closure in the 29 mm ED-MHV. Also, there is a higher probability of cavitation at lower values of the gap width at the point of impact between the leaflet tip and housing. These predictions of cavitation inception are not likely to be significantly influenced by the water-hammer pressure gradient that develops during valve closure.

An alternative model for OPEC stability: The carrot and stick approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akacem, M.; Fleisher, A.A. III

1994-12-31

The Organization of the Petroleum Exporting Countries (OPEC) has gone through turbulent times since its inception in 1960. The decade of the 1970s represented the peak of its power; however, the 1980s and 1990s are characterized by the erosion of OPECs position. After a brief exposition of the principles of resource economics and their relevance to OPEC, we review oligopoly theory and its specific application to OPEC. A model of cartel behavior will then be presented and its relevance to OPEC will be emphasized. Our theory is that OPEC can use a trigger price strategy (a punishment phase when overproductionmore » occurs, followed by a resumption phase of full compliance of the quota agreement) to stabilize output. An insurance policy scheme will be presented in combination with the trigger price strategy, the goal of which may improve the stability of OPEC. Finally, we shall show how the present organization may evolve over time into a much smaller entity by the late 1990s composed of the Gulf producers.« less

Investigation of turbocharger compressor surge inception by means of an acoustic two-port model

NASA Astrophysics Data System (ADS)

Kabral, R.; Åbom, M.

2018-01-01

The use of centrifugal compressors have increased tremendously in the last decade being implemented in the modern IC engine design as a key component. However, an efficient implementation is restricted by the compression system surge phenomenon. The focus in the investigation of surge inception have mainly been on the aerodynamic field while neglecting the acoustic field. In the present work a new method based on the full acoustic 2-port model is proposed for investigation of centrifugal compressor stall and surge inception. Essentially, the compressor is acoustically decoupled from the compression system, hence enabling the determination of sound generation and the quantification of internal aero-acoustic coupling effects, both independently of the connected pipe system. These frequency dependent quantities are indicating if the compressor is prone to self-sustained oscillations in case of positive feedback when installed in a system. The method is demonstrated on experimentally determined 2-port data of an automotive turbocharger centrifugal compressor under a variety of realistic operating conditions.

Fifth Semiannual Report of the Commission to the Congress: Atomic Energy Development, 1947- 1948

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lilienthal, David E.; Bacher, Robert F.; Pike, Sumner T.

1949-01-01

The document represents the fifth semiannual report to Congress, covering specifically the various developments in atomic energy since the inception of the Atomic Energy Commission in 1946. This fifth report represents an expansion of effort in all phases of atomic energy development and is prepared against a background of world affairs.

Overview of physical models of liquid entrainment in annular gas-liquid flow

NASA Astrophysics Data System (ADS)

Cherdantsev, Andrey V.

2018-03-01

A number of recent papers devoted to development of physically-based models for prediction of liquid entrainment in annular regime of two-phase flow are analyzed. In these models shearing-off the crests of disturbance waves by the gas drag force is supposed to be the physical mechanism of entrainment phenomenon. The models are based on a number of assumptions on wavy structure, including inception of disturbance waves due to Kelvin-Helmholtz instability, linear velocity profile inside liquid film and high degree of three-dimensionality of disturbance waves. Validity of the assumptions is analyzed by comparison to modern experimental observations. It was shown that nearly every assumption is in strong qualitative and quantitative disagreement with experiments, which leads to massive discrepancies between the modeled and real properties of the disturbance waves. As a result, such models over-predict the entrained fraction by several orders of magnitude. The discrepancy is usually reduced using various kinds of empirical corrections. This, combined with empiricism already included in the models, turns the models into another kind of empirical correlations rather than physically-based models.

Three-dimensional numerical simulations of turbulent cavitating flow in a rectangular channel

NASA Astrophysics Data System (ADS)

Iben, Uwe; Makhnov, Andrei; Schmidt, Alexander

2018-05-01

Cavitation is a phenomenon of formation of bubbles (cavities) in liquid as a result of pressure drop. Cavitation plays an important role in a wide range of applications. For example, cavitation is one of the key problems of design and manufacturing of pumps, hydraulic turbines, ship's propellers, etc. Special attention is paid to cavitation erosion and to performance degradation of hydraulic devices (noise, fluctuations of the mass flow rate, etc.) caused by the formation of a two-phase system with an increased compressibility. Therefore, development of a model to predict cavitation inception and collapse of cavities in high-speed turbulent flows is an important fundamental and applied task. To test the algorithm three-dimensional simulations of turbulent flow of a cavitating liquid in a rectangular channel have been conducted. The obtained results demonstrate the efficiency and robustness of the formulated model and the algorithm.

Example of a Fluid-Phase Change Examined with MD Simulation: Evaporative Cooling of a Nanoscale Droplet.

PubMed

Ao, Takashi; Matsumoto, Mitsuhiro

2017-10-24

We carried out a series of molecular dynamics simulations in order to examine the evaporative cooling of a nanoscale droplet of a Lennard-Jones liquid. After thermally equilibrating a droplet at a temperature T ini /T t ≃ 1.2 (T t is the triple-point temperature), we started the evaporation into vacuum by removing vaporized particles and monitoring the change in droplet size and the temperature inside. As free evaporation proceeds, the droplet reaches a deep supercooled liquid state of T/T t ≃ 0.7. The temperature was found to be uniform in spite of the fast evaporative cooling on the surface. The time evolution of the evaporating droplet properties was satisfactorily explained with a simple one-dimensional phase-change model. After a sufficiently long run, the supercooled droplet was crystallized into a polycrystalline fcc structure. The crystallization is a stochastic nucleation process. The time and the temperature of inception were evaluated over 42 samples, which indicate the existence of a stability limit.

Ethnography of a Sustainable Agriculture Program: A Case Study of a Social Movement's Inception and Growth on a University Campus

ERIC Educational Resources Information Center

Triana, Benjamin

2016-01-01

This ethnography documents how the message of sustainability was interpreted and communicated through a sustainable agricultural (SAG) program at an American higher education institution. The ethnography documents the evolution of the program as the program tackled obstacles and accomplished its goals during the initial phases of the program's…

Critical insolation-CO2 relation for diagnosing past and future glacial inception.

PubMed

Ganopolski, A; Winkelmann, R; Schellnhuber, H J

2016-01-14

The past rapid growth of Northern Hemisphere continental ice sheets, which terminated warm and stable climate periods, is generally attributed to reduced summer insolation in boreal latitudes. Yet such summer insolation is near to its minimum at present, and there are no signs of a new ice age. This challenges our understanding of the mechanisms driving glacial cycles and our ability to predict the next glacial inception. Here we propose a critical functional relationship between boreal summer insolation and global carbon dioxide (CO2) concentration, which explains the beginning of the past eight glacial cycles and might anticipate future periods of glacial inception. Using an ensemble of simulations generated by an Earth system model of intermediate complexity constrained by palaeoclimatic data, we suggest that glacial inception was narrowly missed before the beginning of the Industrial Revolution. The missed inception can be accounted for by the combined effect of relatively high late-Holocene CO2 concentrations and the low orbital eccentricity of the Earth. Additionally, our analysis suggests that even in the absence of human perturbations no substantial build-up of ice sheets would occur within the next several thousand years and that the current interglacial would probably last for another 50,000 years. However, moderate anthropogenic cumulative CO2 emissions of 1,000 to 1,500 gigatonnes of carbon will postpone the next glacial inception by at least 100,000 years. Our simulations demonstrate that under natural conditions alone the Earth system would be expected to remain in the present delicately balanced interglacial climate state, steering clear of both large-scale glaciation of the Northern Hemisphere and its complete deglaciation, for an unusually long time.

3D PIC-MCC simulations of discharge inception around a sharp anode in nitrogen/oxygen mixtures

NASA Astrophysics Data System (ADS)

Teunissen, Jannis; Ebert, Ute

2016-08-01

We investigate how photoionization, electron avalanches and space charge affect the inception of nanosecond pulsed discharges. Simulations are performed with a 3D PIC-MCC (particle-in-cell, Monte Carlo collision) model with adaptive mesh refinement for the field solver. This model, whose source code is available online, is described in the first part of the paper. Then we present simulation results in a needle-to-plane geometry, using different nitrogen/oxygen mixtures at atmospheric pressure. In these mixtures non-local photoionization is important for the discharge growth. The typical length scale for this process depends on the oxygen concentration. With 0.2% oxygen the discharges grow quite irregularly, due to the limited supply of free electrons around them. With 2% or more oxygen the development is much smoother. An almost spherical ionized region can form around the electrode tip, which increases in size with the electrode voltage. Eventually this inception cloud destabilizes into streamer channels. In our simulations, discharge velocities are almost independent of the oxygen concentration. We discuss the physical mechanisms behind these phenomena and compare our simulations with experimental observations.

A value-based, no-cost-to-patient health model in the developing world: Critical appraisal of a unique patient-centric neurosurgery unit

PubMed Central

Thakar, Sumit; Dadlani, Ravi; Sivaraju, Laxminadh; Aryan, Saritha; Mohan, Dilip; Sai Kiran, Narayanam Anantha; Rajarathnam, Ravikiran; Shyam, Maya; Sadanand, Venkatraman; Hegde, Alangar S.

2015-01-01

Background: It is well-accepted that the current healthcare scenario worldwide is due for a radical change, given that it is fraught with mounting costs and varying quality. Various modifications in health policies have been instituted toward this end. An alternative model, the low-cost, value-based health model, focuses on maximizing value for patients by moving away from a physician-centered, supply-driven system to a patient-centered system. Methods: The authors discuss the successful inception, functioning, sustainability, and replicability of a novel health model in neurosurgery built and sustained by inspired humanitarianism and that provides all treatment at no cost to the patients irrespective of their socioeconomic strata, color or creed. Results: The Sri Sathya Sai Institute of Higher Medical Sciences (SSSIHMS) at Whitefield, Bengaluru, India, a private charitable hospital established in 2001, functions on the ideals of providing free state-of-the-art healthcare to all in a compassionate and holistic manner. With modern equipment and respectable outcome benchmarks, its neurosurgery unit has operated on around 18,000 patients since its inception, and as such, has contributed INR 5310 million (USD 88.5 million) to society from an economic standpoint. Conclusions: The inception and sustainability of the SSSIHMS model are based on self-perpetuating philanthropy, a cost-conscious culture and the dissemination of human values. Replicated worldwide, at least in the developing nations, this unique healthcare model may well change the face of healthcare economics. PMID:26322241

A systematic experimental investigation of significant parameters affecting model tire hydroplaning

NASA Technical Reports Server (NTRS)

Wray, G. A.; Ehrlich, I. R.

1973-01-01

The results of a comprehensive parametric study of model and small pneumatic tires operating on a wet surface are presented. Hydroplaning inception (spin down) and rolling restoration (spin up) are discussed. Conclusions indicate that hydroplaning inception occurs at a speed significantly higher than the rolling restoration speed. Hydroplaning speed increases considerably with tread depth, surface roughness and tire inflation pressure of footprint pressure, and only moderately with increased load. Water film thickness affects spin down speed only slightly. Spin down speed varies inversely as approximately the one-sixth power of film thickness. Empirical equations relating tire inflation pressure, normal load, tire diameter and water film thickness have been generated for various tire tread and surface configurations.

Study of capabilities and limitations of 3D printing technology

NASA Astrophysics Data System (ADS)

Lemu, H. G.

2012-04-01

3D printing is one of the developments in rapid prototyping technology. The inception and development of the technology has highly assisted the product development phase of product design and manufacturing. The technology is particularly important in educating product design and 3D modeling because it helps students to visualize their design idea, to enhance their creative design process and enables them to touch and feel the result of their innovative work. The availability of many 3D printers on the market has created a certain level of challenge for the user. Among others, complexity of part geometry, material type, compatibility with 3D CAD models and other technical aspects still need in-depth study. This paper presents results of the experimental work on the capabilities and limitations of the Z510 3D printer from Z-corporation. Several parameters such as dimensional and geometrical accuracy, surface quality and strength as a function of model size, orientation and file exchange format are closely studied.

Prediction models for successful external cephalic version: a systematic review.

PubMed

Velzel, Joost; de Hundt, Marcella; Mulder, Frederique M; Molkenboer, Jan F M; Van der Post, Joris A M; Mol, Ben W; Kok, Marjolein

2015-12-01

To provide an overview of existing prediction models for successful ECV, and to assess their quality, development and performance. We searched MEDLINE, EMBASE and the Cochrane Library to identify all articles reporting on prediction models for successful ECV published from inception to January 2015. We extracted information on study design, sample size, model-building strategies and validation. We evaluated the phases of model development and summarized their performance in terms of discrimination, calibration and clinical usefulness. We collected different predictor variables together with their defined significance, in order to identify important predictor variables for successful ECV. We identified eight articles reporting on seven prediction models. All models were subjected to internal validation. Only one model was also validated in an external cohort. Two prediction models had a low overall risk of bias, of which only one showed promising predictive performance at internal validation. This model also completed the phase of external validation. For none of the models their impact on clinical practice was evaluated. The most important predictor variables for successful ECV described in the selected articles were parity, placental location, breech engagement and the fetal head being palpable. One model was assessed using discrimination and calibration using internal (AUC 0.71) and external validation (AUC 0.64), while two other models were assessed with discrimination and calibration, respectively. We found one prediction model for breech presentation that was validated in an external cohort and had acceptable predictive performance. This model should be used to council women considering ECV. Copyright © 2015. Published by Elsevier Ireland Ltd.

Viking lander spacecraft battery

NASA Technical Reports Server (NTRS)

Newell, D. R.

1976-01-01

The Viking Lander was the first spacecraft to fly a sterilized nickel-cadmium battery on a mission to explore the surface of a planet. The significant results of the battery development program from its inception through the design, manufacture, and test of the flight batteries which were flown on the two Lander spacecraft are documented. The flight performance during the early phase of the mission is also presented.

Viking Lander spacecraft battery. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Newell, D.R.

1976-09-01

The Viking Lander was the first spacecraft to fly a sterilized nickel--cadmium battery on a mission to explore the surface of a planet. The significant results of the battery development program from its inception through the design, manufacture, and test of the flight batteries which were flown on the two Lander spacecraft are documented. The flight performance during the early phase of the mission is also presented.

Integrated approach to modeling long-term durability of concrete engineered barriers in LLRW disposal facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, J.H.; Roy, D.M.; Mann, B.

1995-12-31

This paper describes an integrated approach to developing a predictive computer model for long-term performance of concrete engineered barriers utilized in LLRW and ILRW disposal facilities. The model development concept consists of three major modeling schemes: hydration modeling of the binder phase, pore solution speciation, and transport modeling in the concrete barrier and service environment. Although still in its inception, the model development approach demonstrated that the chemical and physical properties of complex cementitious materials and their interactions with service environments can be described quantitatively. Applying the integrated model development approach to modeling alkali (Na and K) leaching from amore » concrete pad barrier in an above-grade tumulus disposal unit, it is predicted that, in a near-surface land disposal facility where water infiltration through the facility is normally minimal, the alkalis control the pore solution pH of the concrete barriers for much longer than most previous concrete barrier degradation studies assumed. The results also imply that a highly alkaline condition created by the alkali leaching will result in alteration of the soil mineralogy in the vicinity of the disposal facility.« less

CISNET: Model Documentation

Cancer.gov

The Publications pages provide lists of all CISNET publications since the inception of CISNET. Publications are listed by Cancer Site or by Research Topic. The Publication Support and Modeling Resources pages provides access to technical modeling information, raw data, and publication extensions stemming from the work of the CISNET consortium.

US NDC Modernization: Service Oriented Architecture Study Status

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamlet, Benjamin R.; Encarnacao, Andre Villanova; Harris, James M.

2014-12-01

This report is a progress update on the USNDC Modernization Service Oriented Architecture (SOA) study describing results from Inception Iteration 1, which occurred between October 2012 and March 2013. The goals during this phase are 1) discovering components of the system that have potential service implementations, 2) identifying applicable SOA patterns for data access, service interfaces, and service orchestration/choreography, and 3) understanding performance tradeoffs for various SOA patterns

Characterizing cartilage microarchitecture on phase-contrast x-ray computed tomography using deep learning with convolutional neural networks

NASA Astrophysics Data System (ADS)

Deng, Botao; Abidin, Anas Z.; D'Souza, Adora M.; Nagarajan, Mahesh B.; Coan, Paola; Wismüller, Axel

2017-03-01

The effectiveness of phase contrast X-ray computed tomography (PCI-CT) in visualizing human patellar cartilage matrix has been demonstrated due to its ability to capture soft tissue contrast on a micrometer resolution scale. Recent studies have shown that off-the-shelf Convolutional Neural Network (CNN) features learned from a nonmedical data set can be used for medical image classification. In this paper, we investigate the ability of features extracted from two different CNNs for characterizing chondrocyte patterns in the cartilage matrix. We obtained features from 842 regions of interest annotated on PCI-CT images of human patellar cartilage using CaffeNet and Inception-v3 Network, which were then used in a machine learning task involving support vector machines with radial basis function kernel to classify the ROIs as healthy or osteoarthritic. Classification performance was evaluated using the area (AUC) under the Receiver Operating Characteristic (ROC) curve. The best classification performance was observed with features from Inception-v3 network (AUC = 0.95), which outperforms features extracted from CaffeNet (AUC = 0.91). These results suggest that such characterization of chondrocyte patterns using features from internal layers of CNNs can be used to distinguish between healthy and osteoarthritic tissue with high accuracy.

A Numerical Study of Cavitation Inception in Complex Flow Fields

DTIC Science & Technology

2007-12-01

field in a tip vortex flow of an open propeller to better describe the interaction between the blade wake and the tip vortex (i.e. the roll-up... WAKE INTERACTION ON CAVITATION INCEPTION IN AN OPEN PROPELLER ................15 2.5 NON-SPHERICAL BUBBLE EFFECTS ON CAVITATION INCEPTION [14,15...18 2.6 STUDY OF CAVITATION INCEPTION NOISE [16,17,18

Final Report, Fundamental Mechanisms of Transient States in Materials Quantified by DTEM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campbell, G. H.; McKeown, J. T.

At the project’s inception, there was growing evidence that the time domain for in situ observations of material evolution held great promise for allowing measurements to be made in never previously contemplated regimes. Also, central to the development of the project was the knowledge that phase transformations are of central importance to the development of materials microstructure and hence properties. We addressed this opportunity by developing a transmission electron microscope that could be operated in the pulsed mode (DTEM), with exposure times down to 20 ns and interframe times down to 20 ns in the nine-frame movie mode, designed withmore » the intent of performing in situ experiments. This unprecedented capability allowed us to investigate structural phase transformations, intermetallic formation reactions, crystallization from the amorphous phase, rapid solidification of liquid metals, transformations in phase change materials, and catalyst nanoparticles. The ability of the electron microscope to create images with high spatial resolution allows for the accurate measurement of position. Common to all of the transformations mentioned above is the presence of a distinct interface between the old phase and the growing new phase. Measuring the position of the interface as a function of time, combined with the ability to count nucleation sites as a function of time, allowed for the exceptionally accurate measure of transformation kinetics. These measurements were used to guide and constrain the development of models and simulation methods for the classes of transformations studied.« less

A transient fully coupled climate-ice-sheet simulation of the last glacial inception

NASA Astrophysics Data System (ADS)

Lofverstrom, M.; Otto-Bliesner, B. L.; Lipscomb, W. H.; Fyke, J. G.; Marshall, S.; Sacks, B.; Brady, E. C.

2017-12-01

The last glacial inception occurred around 115 ka, following a relative minimum in the Northern Hemisphere summer insolation. It is believed that small and spatially separated ice caps initially formed in the high elevation regions of northern Canada, Scandinavia, and along the Siberian Arctic coast. These ice caps subsequently migrated down in the valleys where they coalesced and formed the initial seeds of the large coherent ice masses that covered the northern parts of the North American and Eurasian continents over most of the last glacial cycle. Sea level records show that the initial growth period lasted for about 10 kyrs, and the resulting ice sheets may have lowered the global sea level by as much as 30 to 50 meters. Here we examine the transient climate system evolution over the period between 118 and 110 ka, using the fully coupled Community Earth System Model, version 2 (CESM2). This model features a two-way coupled high-resolution (4x4 km) ice-sheet component (Community Ice Sheet model, version 2; CISM2) that simulates ice sheets as an interactive component of the climate system. We impose a transient forcing protocol where the greenhouse gas concentrations and the orbital parameters follow the nominal year in the simulation; the model topography is also dynamically evolving in order to reflect changes in ice elevation throughout the simulation. The analysis focuses on how the climate system evolves over this time interval, with a special focus on glacial inception in the high-latitude continents. Results will highlight how the evolving ice sheets compare to data and previous model based reconstructions.

Study on the streamer inception characteristics under positive lightning impulse voltage

NASA Astrophysics Data System (ADS)

Wang, Zezhong; Geng, Yinan

2017-11-01

The streamer is the main process in an air gap discharge, and the inception characteristics of streamers have been widely applied in engineering. Streamer inception characteristics under DC voltage have been studied by many researchers, but the inception characteristics under impulse voltage, and particularly under lightning impulse voltage with a high voltage rise rate have rarely been studied. A measurement system based on integrated optoelectronic technology has been proposed in this paper, and the streamer inception characteristics in a 1-m-long rod-plane air gap that was energized by a positive lightning impulse voltage have been researched. We have also measured the streamer inception electric field using electrodes with different radii of curvature and different voltage rise rates. As a result, a modified empirical criterion for the streamer inception electric field that considers the voltage rise rate has been proposed, and the wide applicability of this criterion has been proved. Based on the streamer inception time-lag obtained, we determined that the field distribution obeys a Rayleigh distribution, which explains the change law of the streamer inception time-lag. The characteristic parameter of the Rayleigh distribution lies in the range from 0.6 to 2.5 when the radius of curvature of the electrode head is in the range from 0.5 cm to 2.5 cm and the voltage rise rate ranges from 80 kV/μs to 240kV/μs under positive lightning impulse voltage.

The migration and growth of nuclei in an ideal vortex flow

NASA Astrophysics Data System (ADS)

Zhang, Lingxin; Chen, Linya; Shao, Xueming

2016-12-01

Tip vortex cavitation occurs on ship propellers which can cause significant noise compared to the wet flow. In order to predict the inception of tip vortex cavitation, numerous researches have been investigated about the detailed flow field around the tip. According to informed studies, the inception of tip vortex cavitation is affected by many factors. To understand the effect of water quality on cavitation inception, the motion of nuclei in an ideal vortex flow, i.e., the Rankine vortex flow, was investigated. The one-way coupling point-particle tracking model was employed to simulate the trajectory of nuclei. Meanwhile, Rayleigh-Plesset equation was introduced to describe the growth of nuclei. The results show that the nucleus size has a significant effect on nucleus' trajectory. The capture time of a nucleus is approximately inversely proportional to its radius. The growth of nucleus accelerates its migration in the vortex flow and shortens its capture time, especially for the case of explosive growth.

Corona inception voltage in statorettes with various gas-solid dielectric systems

NASA Technical Reports Server (NTRS)

Bollenbacher, G.; Kempke, E. E., Jr.

1972-01-01

Corona inception voltage was calculated and measured for three statorettes in several gases and gas mixtures at pressures from 50.8 to 1270 torr. In helium the corona inception voltage was lowest, and in air it was highest. In argon and mixtures of helium and xenon the corona inception voltage was between that of air and helium. Correlation between experimental and calculated data was good.

How geoarchaeology and landscape archaeology contribute to niche construction theory (NCT).

PubMed

Kluiving, Sjoerd J

In this paper a review is given of examples of geoarchaeological and landscape archaeological research from four locations throughout Europe. Case-studies from the North Sea coastal zone in the Netherlands and the Eastern Mediterranean are presented to illustrate the potential contribution of geoarchaeology and landscape archaeology to niche construction theory (NCT) studies. Typical landscapes as coast lines, lake shores and rivers as example of small and large scale use of the natural landscape and/or topography are discussed with implications for NCT, mainly over the Holocene period. Through environmental reconstruction, we provide relative dates for starting points when humans (a) were altering their own selective environment as an inceptive change, or (b) responded to a (deteriorated) selective environment in a counteractive change. Geoarchaeology and landscape archaeology valuable contribution to NCT studies is the focus of the disciplines on landscape gradients. NCT phase transitions from inceptive to counteractive changes are proposed as useful alternative in the debate about the onset of the Anthropocene.

Tackling the social determinants of inequalities in health during Phase V of the Healthy Cities Project in Europe.

PubMed

Ritsatakis, Anna; Ostergren, Per-Olof; Webster, Premila

2015-06-01

The WHO European Healthy Cities Network has from its inception aimed at tackling inequalities in health. In carrying out an evaluation of Phase V of the project (2009-13), an attempt was made to examine how far the concept of equity in health is understood and accepted; whether cities had moved further from a disease/medical model to looking at the social determinants of inequalities in health; how far the HC project contributed to cities determining the extent and causes of inequalities in health; what efforts were made to tackle such inequalities and how far inequalities in health may have increased or decreased during Phase V. A broader range of resources was utilized for this evaluation than in previous phases of the project. These indicated that most cities were definitely looking at the broader determinants. Equality in health was better understood and had been included as a value in a range of city policies. This was facilitated by stronger involvement of the HC project in city planning processes. Although almost half the cities participating had prepared a City Health Profile, only few cities had the necessary local level data to monitor changes in inequalities in health. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Using Climate Models to Evaluate Mechanisms of Glacial Inception

NASA Technical Reports Server (NTRS)

Oglesby, Robert J.; Arnold, James E. (Technical Monitor)

2001-01-01

The initiation and subsequent growth of an ice sheet or large glacier is based on two primary factors: 1. Most fundamentally, a region must exist with a positive net snow accumulation, that is, cold season snowfall exceeds warm season snowmelt. Because snow can melt very rapidly, in a practical sense this probably means that little or no snow melt should occur in the warm season (mountain glaciers being one possible exception). 2. When sufficient ice builds in a region with a positive net snow accumulation, the ice will flow into adjoining regions with a negative mass balance. Feedbacks can also then arise between the emerging ice sheet and the overall climate, which, among other effects, may cause the mass balance in that region to turn positive. A key question is the relative importance of these two factors. In particular, is it possible for a large lowland region to experience a positive mass balance, such that the ice sheet can arise largely 'in-situ'? Or instead are uplands necessary, such that essentially mountain glaciers form first, and then, under the right conditions, grow and coalesce, eventually spreading out into the lowlands? This is probably the single most fundamental question to be addressed in the modeling of glacial inception. Other key questions then focus on how the (upland or low-land) positive mass balance is obtained at some times, but not others (the ice sheets are not continuously present). For Northern Hemisphere ice sheets in particular, what climatic conditions can lead to abundant winter snowfall in the Canadian Arctic and northern Labrador in conjunction with cool summertime conditions? Are both required, or will cool summer conditions alone suffice? Conversely, are a few years of abnormally heavy snowfall all that is required to trigger glacial inception? A major need at present is for carefully constructed climate model studies aimed at addressing these questions. A successful strategy will almost certainly require more than just a global model; while the global climate model might be necessary to properly simulate large-scale forcing, such models have insufficient spatial resolution to adequately address the roles of topography and the nature of the land surface. Necessary also is the use of a high-resolution regional climate model (in conjunction with a global model). Possible forcing mechanisms of Pleistocene ice ages are well known (e.g., orbital forcing; CO2 fluctuations) but we must understand and be able to successfully model the actual processes involved in glacial inception before we can fully understand the true roles played by these forcing mechanisms.

CISNET: Resources

Cancer.gov

The Publications pages provide lists of all CISNET publications since the inception of CISNET. Publications are listed by Cancer Site or by Research Topic. The Publication Support and Modeling Resources pages provides access to technical modeling information, raw data, and publication extensions stemming from the work of the CISNET consortium.

System for increasing corona inception voltage of insulating oils

DOEpatents

Rohwein, Gerald J.

1998-01-01

The Corona Inception Voltage of insulating oils is increased by repetitive cycles of prestressing the oil with a voltage greater than the corona inception voltage, and either simultaneously or serially removing byproducts of corona by evacuation and heating the oil.

A numerical experiment that provides new results regarding the inception of separation in the flow around a circular cylinder

NASA Astrophysics Data System (ADS)

Malamataris, Nikolaos; Liakos, Anastasios

2015-11-01

The exact value of the Reynolds number regarding the inception of separation in the flow around a circular cylinder is still a matter of research. This work connects the inception of separation with the calculation of a positive pressure gradient around the circumference of the cylinder. The hypothesis is that inception of separation occurs when the pressure gradient becomes positive around the circumference. From the most cited laboratory experiments that have dealt with that subject of inception of separation only Thom has measured the pressure gradient there at very low Reynolds numbers (up to Re=3.5). For this reason, the experimental conditions of his tunnel are simulated in a new numerical experiment. The full Navier Stokes equations in both two and three dimensions are solved with a home made code that utilizes Galerkin finite elements. In the two dimensional numerical experiment, inception of separation is observed at Re=4.3, which is the lowest Reynolds number where inception has been reported computationally. Currently, the three dimensional experiment is under way, in order to compare if there are effects of three dimensional theory of separation in the conditions of Thom's experiments.

System for increasing corona inception voltage of insulating oils

DOEpatents

Rohwein, G.J.

1998-05-19

The Corona Inception Voltage of insulating oils is increased by repetitive cycles of prestressing the oil with a voltage greater than the corona inception voltage, and either simultaneously or serially removing byproducts of corona by evacuation and heating the oil. 5 figs.

New Insulation Constructions for Aerospace Wiring Applications. Volume 1. Testing and Evaluation

DTIC Science & Technology

1991-06-01

28 S.3.2 CORONA INCEPTION AND EXTINCIION VOLTAGES 5 - 33 5.3.2.. AC CORONA INCEPTION AND EXTINCTION VOLTAGES 5...... - 33 5.3.2.2 DC CORONA ...SETUP ....... .. 5 - 27 5.10 DIELECTRIC CONSTANT TEST RESULTS .......... .. 5 - 32 5.11 AC CORONA INCEPTION AND EXTINCTION TEST, 22 AWG, 8.6 MIL WALL...AIRFRAME WIRE ... .......... 5 - 39 5.12 AC CORONA INCEPTION AND EXTINCTION TEST, 22 AWG, 5.8 MIL WALL, HOOK UP WIRE .... ........... 5 - 40 5.13 AC

Integrated Data Capturing Requirements for 3d Semantic Modelling of Cultural Heritage: the Inception Protocol

NASA Astrophysics Data System (ADS)

Di Giulio, R.; Maietti, F.; Piaia, E.; Medici, M.; Ferrari, F.; Turillazzi, B.

2017-02-01

The generation of high quality 3D models can be still very time-consuming and expensive, and the outcome of digital reconstructions is frequently provided in formats that are not interoperable, and therefore cannot be easily accessed. This challenge is even more crucial for complex architectures and large heritage sites, which involve a large amount of data to be acquired, managed and enriched by metadata. In this framework, the ongoing EU funded project INCEPTION - Inclusive Cultural Heritage in Europe through 3D semantic modelling proposes a workflow aimed at the achievements of efficient 3D digitization methods, post-processing tools for an enriched semantic modelling, web-based solutions and applications to ensure a wide access to experts and non-experts. In order to face these challenges and to start solving the issue of the large amount of captured data and time-consuming processes in the production of 3D digital models, an Optimized Data Acquisition Protocol (DAP) has been set up. The purpose is to guide the processes of digitization of cultural heritage, respecting needs, requirements and specificities of cultural assets.

Numerical simulation of cavitation and atomization using a fully compressible three-phase model

NASA Astrophysics Data System (ADS)

Mithun, Murali-Girija; Koukouvinis, Phoevos; Gavaises, Manolis

2018-06-01

The aim of this paper is to present a fully compressible three-phase (liquid, vapor, and air) model and its application to the simulation of in-nozzle cavitation effects on liquid atomization. The model employs a combination of the homogeneous equilibrium barotropic cavitation model with an implicit sharp interface capturing volume of fluid (VOF) approximation. The numerical predictions are validated against the experimental results obtained for injection of water into the air from a step nozzle, which is designed to produce asymmetric cavitation along its two sides. Simulations are performed for three injection pressures, corresponding to three different cavitation regimes, referred to as cavitation inception, developing cavitation, and hydraulic flip. Model validation is achieved by qualitative comparison of the cavitation, spray pattern, and spray cone angles. The flow turbulence in this study is resolved using the large-eddy simulation approach. The simulation results indicate that the major parameters that influence the primary atomization are cavitation, liquid turbulence, and, to a smaller extent, the Rayleigh-Taylor and Kelvin-Helmholtz aerodynamic instabilities developing on the liquid-air interface. Moreover, the simulations performed indicate that periodic entrainment of air into the nozzle occurs at intermediate cavitation numbers, corresponding to developing cavitation (as opposed to incipient and fully developed cavitation regimes); this transient effect causes a periodic shedding of the cavitation and air clouds and contributes to improved primary atomization. Finally, the cone angle of the spray is found to increase with increased injection pressure but drops drastically when hydraulic flip occurs, in agreement with the relevant experiments.

Simulating the inception of pulsed discharges near positive electrodes

NASA Astrophysics Data System (ADS)

Teunissen, Jannis; Ebert, Ute

2013-09-01

With 3D particle simulations we study the inception of pulsed discharges near positive electrodes. In different geometries, we first determine the breakdown voltage. Then we study the probability of inception for a fast voltage pulse. This probability mostly depends on the availability of seed electrons to generate the initial electron avalanches. These results are compared with experimental observations. Then we investigate how the shape of a starting discharge affects its further development. In particular, we discuss the formation of so-called ``inception clouds.'' JT was supported by STW-project 10755.

Different ontogenetic processes promote dicliny in Ficus L. (Moraceae)

NASA Astrophysics Data System (ADS)

Basso-Alves, João Paulo; Pereira, Rodrigo Augusto Santinelo; Peng, Yang-Qiong; Teixeira, Simone Pádua

2014-05-01

The absence of reproductive organs in flowers may ontogenetically arise from inception or by abortion during development. Ficus L., a species-rich genus of angiosperms, is an interesting model for floral developmental studies because of the diversity of sexual systems it contains. This study compares the floral morphology of Ficus citrifolia (monoecious), Ficus religiosa (monoecious), Ficus racemosa (secondarily monoecious), and Ficus hispida (gynodioecious) across development to establish the ontogenetic pathways that result in diclinous flowers. Figs were collected at various developmental stages and were prepared for surface (scanning electron microscopy) and histological (light microscopy) analyses. Dicliny in Ficus is defined by stamen absence from inception in pistillate flowers and either pistil absence from inception (F. citrifolia, F. racemosa and F. religiosa) or by abortion (F. hispida) in staminate flowers. The perianth is formed by a single whorl of sepals, as found in other families related to Moraceae. The gynoecium is tubular during development, a condition that may be related with pseudomonomery. The staminate and neutral flowers in F. hispida develop by similar mechanisms. The diversity in the sexual systems in Ficus results from combinations of different floral morphs (dicliny), which originate from both previously established ontogenetic mechanisms (loss of reproductive organ function by abortion or from inception). These mechanisms act independently of phylogenetic proximity or mechanisms of sex system evolution in Ficus. Other aspects of floral development observed in Ficus are discussed in relation to their systematic position and reproductive biology.

Facilitating higher-fidelity simulations of axial compressor instability and other turbomachinery flow conditions

NASA Astrophysics Data System (ADS)

Herrick, Gregory Paul

The quest to accurately capture flow phenomena with length-scales both short and long and to accurately represent complex flow phenomena within disparately sized geometry inspires a need for an efficient, high-fidelity, multi-block structured computational fluid dynamics (CFD) parallel computational scheme. This research presents and demonstrates a more efficient computational method by which to perform multi-block structured CFD parallel computational simulations, thus facilitating higher-fidelity solutions of complicated geometries (due to the inclusion of grids for "small'' flow areas which are often merely modeled) and their associated flows. This computational framework offers greater flexibility and user-control in allocating the resource balance between process count and wall-clock computation time. The principal modifications implemented in this revision consist of a "multiple grid block per processing core'' software infrastructure and an analytic computation of viscous flux Jacobians. The development of this scheme is largely motivated by the desire to simulate axial compressor stall inception with more complete gridding of the flow passages (including rotor tip clearance regions) than has been previously done while maintaining high computational efficiency (i.e., minimal consumption of computational resources), and thus this paradigm shall be demonstrated with an examination of instability in a transonic axial compressor. However, the paradigm presented herein facilitates CFD simulation of myriad previously impractical geometries and flows and is not limited to detailed analyses of axial compressor flows. While the simulations presented herein were technically possible under the previous structure of the subject software, they were much less computationally efficient and thus not pragmatically feasible; the previous research using this software to perform three-dimensional, full-annulus, time-accurate, unsteady, full-stage (with sliding-interface) simulations of rotating stall inception in axial compressors utilized tip clearance periodic models, while the scheme here is demonstrated by a simulation of axial compressor stall inception utilizing gridded rotor tip clearance regions. As will be discussed, much previous research---experimental, theoretical, and computational---has suggested that understanding clearance flow behavior is critical to understanding stall inception, and previous computational research efforts which have used tip clearance models have begged the question, "What about the clearance flows?''. This research begins to address that question.

Staying the Course: A Model Leadership Preparation Program that Goes the Distance

ERIC Educational Resources Information Center

Griffin, Leslie L.; Taylor, Thomas R.; Varner, Lynn W.; White, Carole L.

2012-01-01

The Educational Leadership Master's Cohort Program at Delta State University was redesigned in 2011 to reflect current industry standards and streamline the program. Since its inception in the mid-1990s, the program has provided a nationally acclaimed model for principal preparation. The recent redesign focused on preparing school principals to…

The Point of Creative Frustration and the Creative Process: A New Look at an Old Model.

ERIC Educational Resources Information Center

Sapp, D. David

1992-01-01

This paper offers an extension of Graham Wallas' model of the creative process. It identifies periods of problem solving, incubation, and growth with specific points of initial idea inception, creative frustration, and illumination. Responses to creative frustration are described including denial, rationalization, acceptance of stagnation, and new…

PAST, PRESENT AND FUTURE AIR QUALITY MODELING AND ITS APPLICATIONS IN THE UNITED STATES

EPA Science Inventory

Since the inception of the Clean Air Act (CAA) in 1969, atmospheric models have been used to assess source-receptor relationships for sulfur dioxide and total suspended particulate matter (TSP) in the urban areas. The focus through the 1970's has been on the Gaussian dispersio...

Recent Ground Hold and Rapid Depressurization Testing of Multilayer Systems

NASA Technical Reports Server (NTRS)

Johnson, Wesley L.

2014-01-01

In the development of flight insulation systems for large cryogenic orbital storage (spray on foam and multilayer insulation), testing need include all environments that are experienced during flight. While large efforts have been expended on studying, bounding, and modeling the orbital performance of the insulation systems, little effort has been expended on the ground hold and ascent phases of a mission. Historical cryogenic in-space systems that have flown have been able to ignore these phases of flight due to the insulation system being within a vacuum jacket. In the development phase of the Nuclear Mars Vehicle and the Shuttle Nuclear Vehicle, several insulation systems were evaluated for the full mission cycle. Since that time there had been minimal work on these phases of flight until the Constellation program began investigating cryogenic service modules and long duration upper stages. With the inception of the Cryogenic Propellant Storage and Transfer Technology Demonstration Mission, a specific need was seen for the data and as such, several tests were added to the Cryogenic Boil-off Reduction System liquid hydrogen test matrix to provide more data on a insulation system. Testing was attempted with both gaseous nitrogen (GN2) and gaseous helium (GHe) backfills. The initial tests with nitrogen backfill were not successfully completed due to nitrogen liquefaction and solidification preventing the rapid pumpdown of the vacuum chamber. Subsequent helium backfill tests were successful and showed minimal degradation. The results are compared to the historical data.

Programs for Watershed-Plus phase for rainfed regions in India

NASA Astrophysics Data System (ADS)

Ramachandran, Kausalya; Ramakrishna, Y. S.

2006-12-01

Watershed-based development is the strategy for sustainable growth in the vast rain-fed regions of India since 1980s to enhance agricultural production, conservation of natural resources and raising rural livelihood of farming communities. Although soil and water conservation was initially the primary objective of watershed program that saw large public investment since inception, later its focus shifted to principles of equity and enhancing rural livelihood opportunities and more recently to sustainable development since mid-1990s. At present a major emphasis under watershed program is the regeneration of degraded fragile lands in rain-fed regions. Several noteworthy watershed programs have been carried out since inception that have yielded sterling results while many others have yielded little by way of unbalanced development because of improper characterization of watersheds and poor project planning and implementation. Tools of Geomatics like satellite data, GIS and GPS besides conventional ones like field survey, topographical and cadastral maps along with traditional multi-disciplinary methods like PRA, soil and water analysis, socio-economic survey etc. provide insight into characterization of watersheds, project formulation and proper implementation of such development programs. The present paper illustrates the methodology for characterization of watersheds using the tools of Geomatics on one hand, besides exhibiting its utility for scaling-out the program benefits like sustaining higher agricultural productivity, enhancing irrigation efficiency, equity, enhanced rural livelihood opportunities, women empowerment, drought-proofing etc. during Watershed-Plus phase in the coming decades, on the other.

Deep Convolutional Neural Networks Enable Discrimination of Heterogeneous Digital Pathology Images.

PubMed

Khosravi, Pegah; Kazemi, Ehsan; Imielinski, Marcin; Elemento, Olivier; Hajirasouliha, Iman

2018-01-01

Pathological evaluation of tumor tissue is pivotal for diagnosis in cancer patients and automated image analysis approaches have great potential to increase precision of diagnosis and help reduce human error. In this study, we utilize several computational methods based on convolutional neural networks (CNN) and build a stand-alone pipeline to effectively classify different histopathology images across different types of cancer. In particular, we demonstrate the utility of our pipeline to discriminate between two subtypes of lung cancer, four biomarkers of bladder cancer, and five biomarkers of breast cancer. In addition, we apply our pipeline to discriminate among four immunohistochemistry (IHC) staining scores of bladder and breast cancers. Our classification pipeline includes a basic CNN architecture, Google's Inceptions with three training strategies, and an ensemble of two state-of-the-art algorithms, Inception and ResNet. Training strategies include training the last layer of Google's Inceptions, training the network from scratch, and fine-tunning the parameters for our data using two pre-trained version of Google's Inception architectures, Inception-V1 and Inception-V3. We demonstrate the power of deep learning approaches for identifying cancer subtypes, and the robustness of Google's Inceptions even in presence of extensive tumor heterogeneity. On average, our pipeline achieved accuracies of 100%, 92%, 95%, and 69% for discrimination of various cancer tissues, subtypes, biomarkers, and scores, respectively. Our pipeline and related documentation is freely available at https://github.com/ih-_lab/CNN_Smoothie. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

The Historical Evolution of Theories and Conceptual Models for Nursing.

ERIC Educational Resources Information Center

Hawkins, Joellen W.

The development of nursing models can be traced to the inception of nursing as a profession. Florence Nightingale laid the foundation for current nursing practice and differentiated nursing from medicine. The late 19th and early 20th centuries contributed a number of important nurse theorists, better known for other contributions to the neophyte…

Challenges of forest landscape modeling - simulating large landscapes and validating results

Treesearch

Hong S. He; Jian Yang; Stephen R. Shifley; Frank R. Thompson

2011-01-01

Over the last 20 years, we have seen a rapid development in the field of forest landscape modeling, fueled by both technological and theoretical advances. Two fundamental challenges have persisted since the inception of FLMs: (1) balancing realistic simulation of ecological processes at broad spatial and temporal scales with computing capacity, and (2) validating...

2005-2008

ERIC Educational Resources Information Center

Council of Chief State School Officers, 2009

2009-01-01

The purpose of this document is to describe the US ED growth model pilot program from its inception to the point at which the program was no longer a pilot and was opened up to all states. In addition, the paper is designed to help states in the process of planning to submit a growth model proposal. The information in this document is mostly…

Inception horizon concept as a basis for sinkhole hazard mapping

NASA Astrophysics Data System (ADS)

Vouillamoz, J.; Jeannin, P.-Y.; Kopp, L.; Chantry, R.

2012-04-01

The office for natural hazards of the Vaud canton (Switzerland) is interested for a pragmatic approach to map sinkhole hazard in karst areas. A team was created by merging resources from a geoengineering company (CSD) and a karst specialist (SISKA). Large areas in Vaud territory are limestone karst in which the collapse hazard is essentially related to the collapse of soft-rocks covering underground cavities, rather than the collapse of limestone roofs or underground chambers. This statement is probably not valid for cases in gypsum and salt. Thus, for limestone areas, zones of highest danger are voids covered by a thin layer of soft-sediments. The spatial distributions of void and cover-thickness should therefore be used for the hazard assessment. VOID ASSESSMENT Inception features (IF) are millimetre to decimetre thick planes (mainly bedding but also fractures) showing a mineralogical, a granulometrical or a physical contrast with the surrounding formation that make them especially susceptible to karst development (FILIPPONI ET AL., 2009). The analysis of more than 1500 km of cave passage showed that karst conduits are mainly developed along such discrete layers within a limestone series. The so-called Karst-ALEA method (FILIPPONI ET AL., 2011) is based on this concept and aims at assessing the probability of karst conduit occurrences in the drilling of a tunnel. This approach requires as entries the identification of inception features (IF), the recognition of paleo-water-table (PWT), and their respective spatial distribution in a 3D geological model. We suggest the Karst-ALEA method to be adjusted in order to assess the void distribution in subsurface as a basis for sinkhole hazard mapping. Inception features (horizons or fractures) and paleo-water-tables (PWT) have to be first identified using visible caves and dolines. These features should then be introduced into a 3D geological model. Intersections of HI and PWT located close to landsurface are areas with a high probability of karst occurrence. ASSESSMENT OF THE SOFT-SEDIMENT COVER Classical geological investigations (mapping, DEM analysis, drilling, etc.) are used to establish a map of the thickness of soft-sediment on top of the limestone. This can also be included in the 3D model. The combination of the void and soft-sediment information in the 3D model makes it possible to derive the sinkhole hazard map. This is currently being developed and applied in the Vaud canton and first results will be presented. BIBLIOGRAPHY FILIPPONI, M., JEANNIN, P. & TACHER, L. (2009): Evidence of inception horizons in karst conduit networks. Geomorphology, 106, 86-99. FILIPPONI, M., SCHMASSMANN, S., JEANNIN, P. Y. & PARRIAUX, A. (2011): Karst - ALEA - Method a risk assessment method of karst for tunnel projects: Application to the Tunnel of Flims (GR, Switzerland). Proc. 9th conference on limestone hydrogeology. Besançon, France. p. 181-184.

Fundamental properties of cooperative contagion processes

NASA Astrophysics Data System (ADS)

Chen, Li; Ghanbarnejad, Fakhteh; Brockmann, Dirk

2017-10-01

We investigate the effects of cooperativity between contagion processes that spread and persist in a host population. We propose and analyze a dynamical model in which individuals that are affected by one transmissible agent A exhibit a higher than baseline propensity of being affected by a second agent B and vice versa. The model is a natural extension of the traditional susceptible-infected-susceptible model used for modeling single contagion processes. We show that cooperativity changes the dynamics of the system considerably when cooperativity is strong. The system exhibits discontinuous phase transitions not observed in single agent contagion, multi-stability, a separation of the traditional epidemic threshold into different thresholds for inception and extinction as well as hysteresis. These properties are robust and are corroborated by stochastic simulations on lattices and generic network topologies. Finally, we investigate wave propagation and transients in a spatially extended version of the model and show that especially for intermediate values of baseline reproduction ratios the system is characterized by various types of wave-front speeds. The system can exhibit spatially heterogeneous stationary states for some parameters and negative front speeds (receding wave fronts). The two agent model can be employed as a starting point for more complex contagion processes, involving several interacting agents, a model framework particularly suitable for modeling the spread and dynamics of microbiological ecosystems in host populations.

Inception of the Laurentide Ice Sheet using asynchronous coupling of a regional atmospheric model and an ice model

NASA Astrophysics Data System (ADS)

Birch, L.; Cronin, T.; Tziperman, E.

2017-12-01

The climate over the past 0.8 million years has been dominated by ice ages. Ice sheets have grown about every 100 kyrs, starting from warm interglacials, until they spanned continents. State-of-the-art global climate models (GCMs) have difficulty simulating glacial inception, or the transition of Earth's climate from an interglacial to a glacial state. It has been suggested that this failure may be related to their poorly resolved local mountain topography, due to their coarse spatial resolution. We examine this idea as well as the possible role of ice flow dynamics missing in GCMs. We investigate the growth of the Laurentide Ice Sheet at 115 kya by focusing on the mountain glaciers of Canada's Baffin Island, where geologic evidence indicates the last inception occurred. We use the Weather Research and Forecasting model (WRF) in a regional, cloud-resolving configuration with resolved mountain terrain to explore how quickly Baffin Island could become glaciated with the favorable yet realizable conditions of 115 kya insolation, cool summers, and wet winters. Using the model-derived mountain glacier mass balance, we force an ice sheet model based on the shallow-ice approximation, capturing the ice flow that may be critical to the spread of ice sheets away from mountain ice caps. The ice sheet model calculates the surface area newly covered by ice and the change in the ice surface elevation, which we then use to run WRF again. Through this type of iterated asynchronous coupling, we investigate how the regional climate responds to both larger areas of ice cover and changes in ice surface elevation. In addition, we use the NOAH-MP Land model to characterize the importance of land processes, like refreezing. We find that initial ice growth on the Penny Ice Cap causes regional cooling that increases the accumulation on the Barnes Ice Cap. We investigate how ice and topography changes on Baffin Island may impact both the regional climate and the large-scale circulation.

The Open Academic Model for the Systems Engineering Graduate Program at Stevens Institute of Technology

ERIC Educational Resources Information Center

Lasfer, Kahina

2012-01-01

The Systems Engineering Program at Stevens Institute of Technology has developed the Open Academic Model (OAM) to guide its strategic planning and operations since its founding in 2001. Guided by OAM, the Stevens Systems Engineering Program (SSEP) has grown from inception in 2001 into one of the largest in the US. The main objectives of the…

Secondary General Education Teachers' Attitudes toward Inclusion

ERIC Educational Resources Information Center

Wilson, Valerie A.

2014-01-01

Since the inception of the Individuals with Disabilities Education Improvement Act, educators have struggled with including students with disabilities in the general education classroom with their nondisabled peers. The inclusion educational model was utilized in this study to explore secondary teachers' attitudes toward inclusive educational…

Composability-Centered Convolutional Neural Network Pruning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, Xipeng; Guan, Hui; Lim, Seung-Hwan

This work studies the composability of the building blocks ofstructural CNN models (e.g., GoogleLeNet and Residual Networks) in thecontext of network pruning. We empirically validate that a networkcomposed of pre-trained building blocks (e.g. residual blocks andInception modules) not only gives a better initial setting fortraining, but also allows the training process to converge at asignificantly higher accuracy in much less time. Based on thatinsight, we propose a {\\em composability-centered} design for CNNnetwork pruning. Experiments show that this new scheme shortens theconfiguration process in CNN network pruning by up to 186.8X forResNet-50 and up to 30.2X for Inception-V3, and meanwhile, themore » modelsit finds that meet the accuracy requirement are significantly morecompact than those found by default schemes.« less

Managing Epilepsy Well: Emerging e-Tools for epilepsy self-management.

PubMed

Shegog, Ross; Bamps, Yvan A; Patel, Archna; Kakacek, Jody; Escoffery, Cam; Johnson, Erica K; Ilozumba, Ukwuoma O

2013-10-01

The Managing Epilepsy Well (MEW) Network was established in 2007 by the Centers for Disease Control and Prevention Epilepsy Program to expand epilepsy self-management research. The network has employed collaborative research strategies to develop, test, and disseminate evidence-based, community-based, and e-Health interventions (e-Tools) for epilepsy self-management for people with epilepsy, caregivers, and health-care providers. Since its inception, MEW Network collaborators have conducted formative studies (n=7) investigating the potential of e-Health to support epilepsy self-management and intervention studies evaluating e-Tools (n=5). The MEW e-Tools (the MEW website, WebEase, UPLIFT, MINDSET, and PEARLS online training) and affiliated e-Tools (Texting 4 Control) are designed to complement self-management practices in each phase of the epilepsy care continuum. These tools exemplify a concerted research agenda, shared methodological principles and models for epilepsy self-management, and a communal knowledge base for implementing e-Health to improve quality of life for people with epilepsy. © 2013.

Regime, phase and paradigm shifts: making community ecology the basic science for fisheries

PubMed Central

Mangel, Marc; Levin, Phillip S.

2005-01-01

Modern fishery science, which began in 1957 with Beverton and Holt, is ca. 50 years old. At its inception, fishery science was limited by a nineteenth century mechanistic worldview and by computational technology; thus, the relatively simple equations of population ecology became the fundamental ecological science underlying fisheries. The time has come for this to change and for community ecology to become the fundamental ecological science underlying fisheries. This point will be illustrated with two examples. First, when viewed from a community perspective, excess production must be considered in the context of biomass left for predators. We argue that this is a better measure of the effects of fisheries than spawning biomass per recruit. Second, we shall analyse a simple, but still multi-species, model for fishery management that considers the alternatives of harvest regulations, inshore marine protected areas and offshore marine protected areas. Population or community perspectives lead to very different predictions about the efficacy of reserves. PMID:15713590

Semantic Models of Host-Immigrant Relations in Norwegian Education Policies

ERIC Educational Resources Information Center

Garthus-Niegel, Kristian; Oppedal, Brit; Vike, Halvard

2016-01-01

Education has continuously been regarded as a vital tool in Norwegian policymakers' immigrant integration agendas. This study analyzes semantic structures substantiating the policy language of historical Norwegian immigrant education policies from their inception in 1973 until today (2013). The analysis is framed by Kronenfeld's linguistic…

Aligning Kolb's Experiential Learning Theory with a Comprehensive Agricultural Education Model

ERIC Educational Resources Information Center

Baker, Marshall A.; Robinson, J. Shane; Kolb, David A.

2012-01-01

Experiential learning has been a foundational tenant of agricultural education since its inception. However, the theory of experiential education has received limited attention in the permanent agricultural education literature base. As such, this philosophical manuscript examined Kolb's experiential learning process further, and considered the…

Tip leakage vortex dynamics and inception

NASA Astrophysics Data System (ADS)

Oweis, Ghanem; Ceccio, Steven; Jessup, Stuart; Chesnakas, Christopher; Fry, David

2002-11-01

The McCormick rule for tip vortex cavitation scaling predicts that cavitation should take place in the vortex where the average core pressure deficit from the free stream is the largest along the vortex tube. The average core pressure deficit can be calculated from the vortex core size and circulation and these can be measured by LDV or hot wire, among other methods. The same rule applies to the tip vortex from a wall-bounded hydrofoil. Recent cavitation inception experiments on a ducted propeller in the NSWCCD 36 inch water tunnel combined with PIV and LDV measurements of the tip vortex flow are described. These tests reveal a disagreement between the actual inception location and that predicted by the McCormick rule. It is hypothesized that in this case the inception mechanism is related to local flow phenomena associated with local vortex unsteadiness, as opposed to the average vortex parameters (core size and circulation) used in the viscous scaling rule of McCormick. Discussion of the flow field measurements, bubble population, and the noise production from the inception events is given.

On the critical charge required for positive leader inception in long air gaps

NASA Astrophysics Data System (ADS)

Liu, Lipeng; Becerra, Marley

2018-01-01

The amount of the electric charge injected by the streamer corona bursts during the stage of leader inception determines the energy deposited to thermalize the corona stem into a leader segment. This paper is aimed at investigating the critical charge required for positive leader inception in air by using a thermo-hydrodynamic model with a detailed kinetic scheme. In order to simplify the analysis and to speed up the simulation, a reduced kinetic scheme for air is proposed. Numerical comparisons show that the reduced scheme can obtain almost the same results as the previous comprehensive kinetic scheme but with only half of the number of species and reactions. The thermo-hydrodynamic model with the reduced kinetics is then used to solve the radial dynamics of a single stem heated by current pulses typical of streamer corona bursts. The critical charge necessary for the direct transition of a first streamer corona into a leader under electrodes with large curvature radius is estimated between 0.08 and 0.5 µC per stem. Furthermore, the simulation shows that the gas heating of corona stem formed from electrodes with small curvature radius is mainly determined by the total accumulated charge injected by previous streamer corona bursts and the length of the dark periods in between the current pulses. The shape and the number of the corona current pulses in the discharge also play a role and their effects are discussed. It is suggested that the transition into a leader is triggered when a secondary streamer burst is initiated after the gas temperature is increased by the heating of previous streamers to about 1200 K. In addition, it is found that the heating produced by the charge injected by previous streamer corona bursts can be neglected if the dark period to the next burst is larger than few hundreds of µs for a corona stem with moderate initial stem radius. This indicates that the critical charge criterion obtained from laboratory experiments does not hold to evaluate the inception of positive leaders under conditions when long dark periods are present.

Crazing in Polymeric and Composite Systems

DTIC Science & Technology

1990-04-23

these physical variations into consideration in any mathematical modeling and formulation in analyzing the stresses from the time when crazes incept to...as boundary tractions with great strength; any governing mathematical formulation must include this feature for any adequate analysis. Crazes of...constants the mathematical model describing the crazing mechanism have been successful [25-29]. References 1 J. A. Sauer, J. Marin and C. C. Hsiao, J. App

The Organizational History of the Canadian Intercollegiate Athletic Union: SIR/CAR Model and Method for Analyzing Conflict and Change.

ERIC Educational Resources Information Center

Moriarty, Dick

The Sports Institute for Research/Change Agent Research (SIR/CAR) model and method for research in organizational history are used to analyze the growth and development of the Canadian Intercollegiate Athletic Union (CIAU) from its inception in 1906 through its breakup in 1955 and its reestablishment in 1961. Four stages of growth are identified:…

Foreword to the Special Issue on "Dynamic Models in Economics and Finance"

NASA Astrophysics Data System (ADS)

Gardini, Laura; Kubin, Ingrid; Tramontana, Fabio; Wagener, Florian

2018-05-01

International workshops on Dynamic Models in Economics and Finance (MDEF) take place every two years in Urbino (Italy); since the inception of the series in 2000, there have been nine editions. The subject has become a central topic for scholars working on economic dynamics. In 2016 the workshop was held under the auspices of University of Urbino "Carlo Bo" , DESP1

Neuroimaging Research: from Null-Hypothesis Falsification to Out-Of-Sample Generalization

ERIC Educational Resources Information Center

Bzdok, Danilo; Varoquaux, Gaël; Thirion, Bertrand

2017-01-01

Brain-imaging technology has boosted the quantification of neurobiological phenomena underlying human mental operations and their disturbances. Since its inception, drawing inference on neurophysiological effects hinged on classical statistical methods, especially, the general linear model. The tens of thousands of variables per brain scan were…

Blended Professional Development: Toward a Data-Informed Model of Instruction

ERIC Educational Resources Information Center

Nelson, Andrew

2017-01-01

Data and the use of data to make educational decisions have attained new-found prominence in K-12 education following the inception of high-stakes testing and subsequent linking of teacher evaluations and teacher-performance pay to students' outcomes on standardized assessments. Although the research literature suggested students' academic…

Microskills Training: Evolution, Reexamination, and Call for Reform

ERIC Educational Resources Information Center

Ridley, Charles R.; Kelly, Shannon M.; Mollen, Debra

2011-01-01

For more than four decades, the microskills approach has been the dominant paradigm for training entry-level counseling students. At its inception, the model met a critical need: instruction in discrete counseling behaviors, which at the time was conspicuously missing from training curricula. Although these behaviors have become essential…

No Pain, No Gain: The Learning Curve in Assessing Collaboratives.

ERIC Educational Resources Information Center

Rendon, Laura I.; Gans, Wendy L.; Calleroz, Mistalene D.

1998-01-01

Presents a case study of an assessment project designed to evaluate the Ford Foundation's Urban Partnership Program (UPP). Discusses UPP's assessment model and theory, and documents the project's yearly progress since its inception in 1992. Details UPP's goals and outcomes in assisting at-risk students. (EMH)

Thermally induced secondary atomization of droplet in an acoustic field

NASA Astrophysics Data System (ADS)

Basu, Saptarshi; Saha, Abhishek; Kumar, Ranganathan

2012-01-01

We study the thermal effects that lead to instability and break up in acoustically levitated vaporizing fuel droplets. For selective liquids, atomization occurs at the droplet equator under external heating. Short wavelength [Kelvin-Helmholtz (KH)] instability for diesel and bio-diesel droplets triggers this secondary atomization. Vapor pressure, latent heat, and specific heat govern the vaporization rate and temperature history, which affect the surface tension gradient and gas phase density, ultimately dictating the onset of KH instability. We develop a criterion based on Weber number to define a condition for the inception of secondary atomization.

Definition of optical systems payloads

NASA Technical Reports Server (NTRS)

Downey, J. A., III

1981-01-01

The various phases in the formulation of a major NASA project include the inception of the project, planning of the concept, and the project definition. A baseline configuration is established during the planning stage, which serves as a basis for engineering trade studies. Basic technological problems should be recognized early, and a technological verification plan prepared before development of a project begins. A progressive series of iterations is required during the definition phase, illustrating the complex interdependence of existing subsystems. A systems error budget should be established to assess the overall systems performance, identify key performance drivers, and guide performance trades and iterations around these drivers, thus decreasing final systems requirements. Unnecessary interfaces should be avoided, and reasonable design and cost margins maintained. Certain aspects of the definition of the Advanced X-ray Astrophysics Facility are used as an example.

The Physics of a Gymnastics Flight Element

ERIC Educational Resources Information Center

Contakos, Jonas; Carlton, Les G.; Thompson, Bruce; Suddaby, Rick

2009-01-01

From its inception, performance in the sport of gymnastics has relied on the laws of physics to create movement patterns and static postures that appear almost impossible. In general, gymnastics is physics in motion and can provide an ideal framework for studying basic human modeling techniques and physical principles. Using low-end technology and…

Using System Change To Increase and Improve Adoptions: The SWAN Model.

ERIC Educational Resources Information Center

Jones, Martha L.

1999-01-01

Describes Statewide Adoption Network (SWAN) of Pennsylvania and its impact on increasing and improving quality of special-needs adoptions. Notes that program resulted from increases of children in out-of-home care, program is a public and private initiative, and that since its inception, special-needs agencies have increased, financial and…

Cavitation inception from bubble nuclei

PubMed Central

Mørch, K. A.

2015-01-01

The tensile strength of ordinary water such as tap water or seawater is typically well below 1 bar. It is governed by cavitation nuclei in the water, not by the tensile strength of the water itself, which is extremely high. Different models of the nuclei have been suggested over the years, and experimental investigations of bubbles and cavitation inception have been presented. These results suggest that cavitation nuclei in equilibrium are gaseous voids in the water, stabilized by a skin which allows diffusion balance between gas inside the void and gas in solution in the surrounding liquid. The cavitation nuclei may be free gas bubbles in the bulk of water, or interfacial gaseous voids located on the surface of particles in the water, or on bounding walls. The tensile strength of these nuclei depends not only on the water quality but also on the pressure–time history of the water. A recent model and associated experiments throw new light on the effects of transient pressures on the tensile strength of water, which may be notably reduced or increased by such pressure changes. PMID:26442138

Vented Capacitor

DOEpatents

Brubaker, Michael Allen; Hosking, Terry Alan

2006-04-11

A technique of increasing the corona inception voltage (CIV), and thereby increasing the operating voltage, of film/foil capacitors is described. Intentional venting of the capacitor encapsulation improves the corona inception voltage by allowing internal voids to equilibrate with the ambient environment.

Morphodynamics of submarine channel inception revealed by new experimental approach

PubMed Central

de Leeuw, Jan; Eggenhuisen, Joris T.; Cartigny, Matthieu J. B.

2016-01-01

Submarine channels are ubiquitous on the seafloor and their inception and evolution is a result of dynamic interaction between turbidity currents and the evolving seafloor. However, the morphodynamic links between channel inception and flow dynamics have not yet been monitored in experiments and only in one instance on the modern seafloor. Previous experimental flows did not show channel inception, because flow conditions were not appropriately scaled to sustain suspended sediment transport. Here we introduce and apply new scaling constraints for similarity between natural and experimental turbidity currents. The scaled currents initiate a leveed channel from an initially featureless slope. Channelization commences with deposition of levees in some slope segments and erosion of a conduit in other segments. Channel relief and flow confinement increase progressively during subsequent flows. This morphodynamic evolution determines the architecture of submarine channel deposits in the stratigraphic record and efficiency of sediment bypass to the basin floor. PMID:26996440

Effect of ultrasonic cavitation on measurement of sound pressure using hydrophone

NASA Astrophysics Data System (ADS)

Thanh Nguyen, Tam; Asakura, Yoshiyuki; Okada, Nagaya; Koda, Shinobu; Yasuda, Keiji

2017-07-01

Effect of ultrasonic cavitation on sound pressure at the fundamental, second harmonic, and first ultraharmonic frequencies was investigated from low to high ultrasonic intensities. The driving frequencies were 22, 304, and 488 kHz. Sound pressure was measured using a needle-type hydrophone and ultrasonic cavitation was estimated from the broadband integrated pressure (BIP). With increasing square root of electric power applied to a transducer, the sound pressure at the fundamental frequency linearly increased initially, dropped at approximately the electric power of cavitation inception, and afterward increased again. The sound pressure at the second harmonic frequency was detected just below the electric power of cavitation inception. The first ultraharmonic component appeared at around the electric power of cavitation inception at 304 and 488 kHz. However, at 22 kHz, the first ultraharmonic component appeared at a higher electric power than that of cavitation inception.

Validation of the INCEPT: A Multisource Feedback Tool for Capturing Different Perspectives on Physicians' Professional Performance.

PubMed

van der Meulen, Mirja W; Boerebach, Benjamin C M; Smirnova, Alina; Heeneman, Sylvia; Oude Egbrink, Mirjam G A; van der Vleuten, Cees P M; Arah, Onyebuchi A; Lombarts, Kiki M J M H

2017-01-01

Multisource feedback (MSF) instruments are used to and must feasibly provide reliable and valid data on physicians' performance from multiple perspectives. The "INviting Co-workers to Evaluate Physicians Tool" (INCEPT) is a multisource feedback instrument used to evaluate physicians' professional performance as perceived by peers, residents, and coworkers. In this study, we report on the validity, reliability, and feasibility of the INCEPT. The performance of 218 physicians was assessed by 597 peers, 344 residents, and 822 coworkers. Using explorative and confirmatory factor analyses, multilevel regression analyses between narrative and numerical feedback, item-total correlations, interscale correlations, Cronbach's α and generalizability analyses, the psychometric qualities, and feasibility of the INCEPT were investigated. For all respondent groups, three factors were identified, although constructed slightly different: "professional attitude," "patient-centeredness," and "organization and (self)-management." Internal consistency was high for all constructs (Cronbach's α ≥ 0.84 and item-total correlations ≥ 0.52). Confirmatory factor analyses indicated acceptable to good fit. Further validity evidence was given by the associations between narrative and numerical feedback. For reliable total INCEPT scores, three peer, two resident and three coworker evaluations were needed; for subscale scores, evaluations of three peers, three residents and three to four coworkers were sufficient. The INCEPT instrument provides physicians performance feedback in a valid and reliable way. The number of evaluations to establish reliable scores is achievable in a regular clinical department. When interpreting feedback, physicians should consider that respondent groups' perceptions differ as indicated by the different item clustering per performance factor.

Three-dimensional Aerodynamic Instability in Multi-stage Axial Compressors

NASA Technical Reports Server (NTRS)

Suder, Kenneth (Technical Monitor); Tan, Choon-Sooi

2003-01-01

Four separate tasks are reported. The first task: A Computational Model for Short Wavelength Stall Inception and Development In Multi-Stage Compressors; the second task: Three-dimensional Rotating Stall Inception and Effects of Rotating Tip Clearance Asymmetry in Axial Compressors; the third task:Development of an Effective Computational Methodology for Body Force Representation of High-speed Rotor 37; and the fourth task:Development of Circumferential Inlet Distortion through a Representative Eleven Stage High-speed axial compressor. The common theme that threaded throughout these four tasks is the conceptual framework that consists of quantifying flow processes at the fadcompressor blade passage level to define the compressor performance characteristics needed for addressing physical phenomena such compressor aerodynamic instability and compressor response to flow distoriton with length scales larger than compressor blade-to-blade spacing at the system level. The results from these two levels can be synthesized to: (1) simulate compressor aerodynamic instability inception local to a blade rotor tip and its development from a local flow event into the nonlinear limit cycle instability that involves the entire compressor as was demonstrated in the first task; (2) determine the conditions under which compressor stability assessment based on two-dimensional model may not be adequate and the effects of self-induced flow distortion on compressor stability limit as in the second task; (3) quantify multistage compressor response to inlet distortion in stagnation pressure as illustrated in the fourth task; and (4) elucidate its potential applicability for compressor map generation under uniform as well as non-uniform inlet flow given three-dimensional Navier-Stokes solution for each individual blade row as was demonstrated in the third task.

Brief Report: Predicting Functional Disability: One-Year Results From the Scottish Early Rheumatoid Arthritis Inception Cohort.

PubMed

Kronisch, Caroline; McLernon, David J; Dale, James; Paterson, Caron; Ralston, Stuart H; Reid, David M; Tierney, Ann; Harvie, John; McKay, Neil; Wilson, Hilary E; Munro, Robin; Saunders, Sarah; Richmond, Ruth; Baxter, Derek; McMahon, Mike; Kumar, Vinod; McLaren, John; Siebert, Stefan; McInnes, Iain B; Porter, Duncan; Macfarlane, Gary J; Basu, Neil

2016-07-01

To identify baseline prognostic indicators of disability at 1 year within a contemporary early inflammatory arthritis inception cohort and then develop a clinically useful tool to support early patient education and decision-making. The Scottish Early Rheumatoid Arthritis (SERA) inception cohort is a multicenter, prospective study of patients with newly presenting RA or undifferentiated arthritis. SERA data were analyzed to determine baseline predictors of disability (defined as a Health Assessment Questionnaire [HAQ] score of ≥1) at 1 year. Clinical and psychosocial baseline exposures were entered into a forward stepwise logistic regression model. The model was externally validated using newly accrued SERA data and subsequently converted into a prediction tool. Of the 578 participants (64.5% female), 36.7% (n = 212) reported functional disability at 1 year. Functional disability was independently predicted by baseline disability (odds ratio [OR] 2.67 [95% confidence interval (95% CI) 1.98, 3.59]), depression (OR 2.52 [95% CI 1.18, 5.37]), anxiety (OR 2.37 [95% CI 1.33, 4.21]), being in paid employment with absenteeism during the last week (OR 1.19 [95% CI 0.63, 2.23]), not being in paid employment (OR 2.36 [95% CI 1.38, 4.03]), and being overweight (OR 1.61 [95% CI 1.04, 2.50]). External validation (using 113 newly acquired patients) evidenced good discriminative performance with a C statistic of 0.74, and the calibration slope showed no evidence of model overfit (P = 0.31). In the context of modern early inflammatory arthritis treatment paradigms, predictors of disability at 1 year appear to be dominated by psychosocial rather than more traditional clinical measures. This indicates the potential benefit of early access to nonpharmacologic interventions targeting key psychosocial factors, such as mental health and work disability. © 2016, American College of Rheumatology.

The inception of pulsed discharges in air: simulations in background fields above and below breakdown

NASA Astrophysics Data System (ADS)

Sun, Anbang; Teunissen, Jannis; Ebert, Ute

2014-11-01

We investigate discharge inception in air, in uniform background electric fields above and below the breakdown threshold. We perform 3D particle simulations that include a natural level of background ionization in the form of positive and \\text{O}2- ions. In background fields below breakdown, we use a strongly ionized seed of electrons and positive ions to enhance the field locally. In the region of enhanced field, we observe the growth of positive streamers, as in previous simulations with 2D plasma fluid models. The inclusion of background ionization has little effect in this case. When the background field is above the breakdown threshold, the situation is very different. Electrons can then detach from \\text{O}2- and start ionization avalanches in the whole volume. These avalanches together create one extended discharge, in contrast to the ‘double-headed’ streamers found in many fluid simulations.

An improved fault detection classification and location scheme based on wavelet transform and artificial neural network for six phase transmission line using single end data only.

PubMed

Koley, Ebha; Verma, Khushaboo; Ghosh, Subhojit

2015-01-01

Restrictions on right of way and increasing power demand has boosted development of six phase transmission. It offers a viable alternative for transmitting more power, without major modification in existing structure of three phase double circuit transmission system. Inspite of the advantages, low acceptance of six phase system is attributed to the unavailability of a proper protection scheme. The complexity arising from large number of possible faults in six phase lines makes the protection quite challenging. The proposed work presents a hybrid wavelet transform and modular artificial neural network based fault detector, classifier and locator for six phase lines using single end data only. The standard deviation of the approximate coefficients of voltage and current signals obtained using discrete wavelet transform are applied as input to the modular artificial neural network for fault classification and location. The proposed scheme has been tested for all 120 types of shunt faults with variation in location, fault resistance, fault inception angles. The variation in power system parameters viz. short circuit capacity of the source and its X/R ratio, voltage, frequency and CT saturation has also been investigated. The result confirms the effectiveness and reliability of the proposed protection scheme which makes it ideal for real time implementation.

MUFOLD-SS: New deep inception-inside-inception networks for protein secondary structure prediction.

PubMed

Fang, Chao; Shang, Yi; Xu, Dong

2018-05-01

Protein secondary structure prediction can provide important information for protein 3D structure prediction and protein functions. Deep learning offers a new opportunity to significantly improve prediction accuracy. In this article, a new deep neural network architecture, named the Deep inception-inside-inception (Deep3I) network, is proposed for protein secondary structure prediction and implemented as a software tool MUFOLD-SS. The input to MUFOLD-SS is a carefully designed feature matrix corresponding to the primary amino acid sequence of a protein, which consists of a rich set of information derived from individual amino acid, as well as the context of the protein sequence. Specifically, the feature matrix is a composition of physio-chemical properties of amino acids, PSI-BLAST profile, and HHBlits profile. MUFOLD-SS is composed of a sequence of nested inception modules and maps the input matrix to either eight states or three states of secondary structures. The architecture of MUFOLD-SS enables effective processing of local and global interactions between amino acids in making accurate prediction. In extensive experiments on multiple datasets, MUFOLD-SS outperformed the best existing methods and other deep neural networks significantly. MUFold-SS can be downloaded from http://dslsrv8.cs.missouri.edu/~cf797/MUFoldSS/download.html. © 2018 Wiley Periodicals, Inc.

Foregrounding Equity in Teacher Education: Toward a Model of Social Justice Pedagogical and Content Knowledge

ERIC Educational Resources Information Center

Dyches, Jeanne; Boyd, Ashley

2017-01-01

Since its inception 30 years ago, Shulman's Pedagogical Content Knowledge (PCK) has fundamentally altered the landscape of teacher preparation. Despite its prominence in the field, the paradigm fails to delineate a space for the role of social justice in classroom practices and teacher preparation. Accordingly, we complicate the relationship…

Learning by Living: Life-Altering Medical Education through Nursing Home-Based Experiential Learning

ERIC Educational Resources Information Center

Gugliucci, Marilyn R.; Weiner, Audrey

2013-01-01

The University of New England College of Osteopathic Medicine Learning by Living Project (referred to as Learning by Living) was piloted in 2006 as an experiential medical education learning model. Since its inception, medical and other health professions students have been "admitted" into nursing homes to live the life of an older adult nursing…

Pluralizing Methodologies in the Field of LD: From "What Works" to What Matters

ERIC Educational Resources Information Center

Ferri, Beth A.; Gallagher, Deborah; Connor, David J.

2011-01-01

The field of learning disabilities (LD) has a complex and complicated history. Tensions over definitions, eligibility criteria, service delivery models, and best practices, as well as epistemological debates, have been a part of that history from its inception. Given our collective struggles, as well as the current realities facing the field,…

Shaken and Stirred: A Pilot Project in Arts and Special Education

ERIC Educational Resources Information Center

Ponder, Carol; Kissinger, Lori

2009-01-01

In this article, the authors describe VSA arts Tennessee's pilot arts in education project and the many good questions that have arisen from it. From VSA's inception in 2002, Lori Kissinger, Executive Director of VSA Tennessee, planned to find a way to partner with the Tennessee Department of Education based on other state models. VSA arts…

A Door Is a Big Wooden Thing with a Knob: Getting a Handle on Metaphorical Interface Design.

ERIC Educational Resources Information Center

Bishop, M. J.; Cates, Ward Mitchell

This paper chronicles the evolution of a metaphorical graphical user interface (MGUI) at Lehigh University (Pennsylvania). From its inception, "The Funeral of Edgar" has been a guided exploration of Edgar Allan Poe's poem, "The Raven," aimed at modeling high school students' critical and analytical reading skills. This product…

The Potential of Experiential Learning Models and Practices in Career and Technical Education and Career and Technical Teacher Education

ERIC Educational Resources Information Center

Clark, Robert W.; Threeton, Mark D.; Ewing, John C.

2010-01-01

Since inception, career and technical education programs have embraced experiential learning as a true learning methodology for students to obtain occupational skills valued by employers. Programs have integrated classroom instruction with laboratory experiences to provide students a significant opportunity to learn. However, it is questionable as…

The Improvement of Measurement in Education and Psychology: Contributions of Latent Trait Theories.

ERIC Educational Resources Information Center

Spearritt, Donald, Ed.

Educational and psychological measurement has been a main area of work for the Australian Council for Educational (ACER) since its inception. The theoretical and practical contributions of latent trait measurement and commentary on the relatively recent use of these models in Australia were the focus of a seminar celebrating the 50th anniversary…

Inception of supraglacial channelization under turbulent flow conditions

NASA Astrophysics Data System (ADS)

Mantelli, E.; Camporeale, C.; Ridolfi, L.

2013-12-01

Glacier surfaces exhibit an amazing variety of meltwater-induced morphologies, ranging from small scale ripples and dunes on the bed of supraglacial channels to meandering patterns, till to large scale drainage networks. Even though the structure and geometry of these morphologies play a key role in the glacier melting processes, the physical-based modeling of such spatial patterns have attracted less attention than englacial and subglacial channels. In order to partially fill this gap, our work concerns the large scale channelization occurring on the ice slopes and focuses on the role of turbulence on the wavelength selection processes during the channelization inception. In a recent study[1], two of us showed that the morphological instability induced by a laminar film flowing over an ice bed is characterized by transversal length scales of order of centimeters. Being these scales much smaller than the spacing observed in the channelization of supraglacial drainage networks (that are of order of meters) and considering that the water films flowing on glaciers can exhibit Reynolds numbers larger than 104, we investigated the role of turbulence in the inception of channelization. The flow-field is modeled by means of two-dimensional shallow water equations, where Reynolds stresses are also considered. In the depth-averaged heat balance equation an incoming heat flux from air is assumed and forced convection heat exchange with the wall is taken into account, in addition to convection and diffusion in the liquid. The temperature profile in the ice is finally coupled to the liquid through Stefan equation. We then perform a linear stability analysis and, under the assumption of small Stefan number, we solve the differential eigenvalue problem analytically. As main outcome of such an analysis, the morphological instability of the ice-water interface is detected and investigated in a wide range of the independent parameters: longitudinal and transversal wavenumbers, glacier surface slope, and Froude number and temperature of the water stream. The most remarkable result is that critical transversal wavelengths of order of meters are obtained, which are in general agreement with the patterns observed on glaciers during the melting season. Moreover, the key role played by the free surface of the water film, turbulent heat transfer and Reynolds stresses on the inception of channelization is highlighted and discussed. [1] Camporeale, C. & Ridolfi, L. (2012) Ice ripple formation at large Reynolds number. J. Fluid Mech. 694, 225-251.

Role of practice-based research networks in comparative effectiveness research.

PubMed

Hartung, Daniel M; Guise, Jeanne-Marie; Fagnan, Lyle J; Davis, Melinda M; Stange, Kurt C

2012-01-01

Comparative effectiveness research fundamentally reorients how clinical evidence is generated and used with the goal of providing actionable information to decision-makers. To achieve this, it is vital that decision-makers and the research enterprise are engaged from research inception, to evidence generation and translation. Practice-based research networks are affiliated clinicians in diverse communities with the goal of conducting research to improve care. Practice-based research networks have the potential to advance all phases of the comparative effectiveness research cycle. The aim of this paper is to explore current and potential roles of practice-based research networks in conducting comparative effectiveness research.

Discrete Wavelet Transform for Fault Locations in Underground Distribution System

NASA Astrophysics Data System (ADS)

Apisit, C.; Ngaopitakkul, A.

2010-10-01

In this paper, a technique for detecting faults in underground distribution system is presented. Discrete Wavelet Transform (DWT) based on traveling wave is employed in order to detect the high frequency components and to identify fault locations in the underground distribution system. The first peak time obtained from the faulty bus is employed for calculating the distance of fault from sending end. The validity of the proposed technique is tested with various fault inception angles, fault locations and faulty phases. The result is found that the proposed technique provides satisfactory result and will be very useful in the development of power systems protection scheme.

Role of practice-based research networks in comparative effectiveness research

PubMed Central

Hartung, Daniel M; Guise, Jeanne-Marie; Fagnan, Lyle J; Davis, Melinda M; Stange, Kurt C

2012-01-01

Comparative effectiveness research fundamentally reorients how clinical evidence is generated and used with the goal of providing actionable information to decision-makers. To achieve this, it is vital that decision-makers and the research enterprise are engaged from research inception, to evidence generation and translation. Practice-based research networks are affiliated clinicians in diverse communities with the goal of conducting research to improve care. Practice-based research networks have the potential to advance all phases of the comparative effectiveness research cycle. The aim of this paper is to explore current and potential roles of practice-based research networks in conducting comparative effectiveness research. PMID:23105964

Tracking and data system support for the Viking 1975 mission to Mars. Volume 1: Prelaunch planning, implementation, and testing

NASA Technical Reports Server (NTRS)

Mudgway, D. J.; Traxler, M. R.

1977-01-01

The tracking and data acquisition support for the 1975 Viking Missions to Mars is described. The history of the effort from its inception in late 1968 through the launches of Vikings 1 and 2 from Cape Kennedy in August and September 1975 is given. The Viking mission requirements for tracking and data acquisition support in both the near earth and deep space phases involved multiple radar tracking and telemetry stations, and communications networks together with the global network of tracking stations, communications, and control center. The planning, implementation, testing and management of the program are presented.

A history of women and feminist perspectives in community psychology.

PubMed

Bond, M A; Mulvey, A

2000-10-01

Using an historical framework, we document and assess efforts to include women, women's issues, and feminism in community psychology and in the Society for Community Research and Action (SCRA). Initiatives of the SCRA Task Force/Committee on Women are traced from its inception to present. We also chronicle the dilemmas and difficulties of moving toward a feminist community psychology. The history is divided into five phases. Each phase is described in terms of women's involvement in the field and efforts to integrate feminist content into research and practice of the field. Reflections on the qualities of contexts that have both supported and inhibited inclusion are identified. We look to this history to try to understand the observation that while women have been increasingly visible in leadership roles and women's professional development has been encouraged, less progress has been made toward building a feminist community psychology.

European Vaccine Initiative: lessons from developing malaria vaccines.

PubMed

Geels, Mark J; Imoukhuede, Egeruan B; Imbault, Nathalie; van Schooten, Harry; McWade, Terry; Troye-Blomberg, Marita; Dobbelaer, Roland; Craig, Alister G; Leroy, Odile

2011-12-01

For over 10 years, the European Vaccine Initiative (EVI; European Malaria Vaccine Initiative until 2009) has contributed to the development of 24 malaria candidate vaccine antigens with 13 vaccine candidates being advanced into Phase I clinical trials, two of which have been transitioned for further clinical development in sub-Saharan Africa. Since its inception the EVI organization has operated as a funding agency, but with a clear service-oriented strategy. The scientific successes and difficulties encountered during these years and how these efforts have led to standardization and harmonization in vaccine development through large-scale European consortia are discussed. In the future, the EVI will remain instrumental in the pharmaceutical and clinical development of vaccines against 'diseases of poverty' with a continued focus on malaria. EVI will continue to focus on funding and managing preclinical evaluation up to Phase I/II clinical trials and strengthening the vaccine-development infrastructure in Europe, albeit with a global orientation.

A soft computing scheme incorporating ANN and MOV energy in fault detection, classification and distance estimation of EHV transmission line with FSC.

PubMed

Khadke, Piyush; Patne, Nita; Singh, Arvind; Shinde, Gulab

2016-01-01

In this article, a novel and accurate scheme for fault detection, classification and fault distance estimation for a fixed series compensated transmission line is proposed. The proposed scheme is based on artificial neural network (ANN) and metal oxide varistor (MOV) energy, employing Levenberg-Marquardt training algorithm. The novelty of this scheme is the use of MOV energy signals of fixed series capacitors (FSC) as input to train the ANN. Such approach has never been used in any earlier fault analysis algorithms in the last few decades. Proposed scheme uses only single end measurement energy signals of MOV in all the 3 phases over one cycle duration from the occurrence of a fault. Thereafter, these MOV energy signals are fed as input to ANN for fault distance estimation. Feasibility and reliability of the proposed scheme have been evaluated for all ten types of fault in test power system model at different fault inception angles over numerous fault locations. Real transmission system parameters of 3-phase 400 kV Wardha-Aurangabad transmission line (400 km) with 40 % FSC at Power Grid Wardha Substation, India is considered for this research. Extensive simulation experiments show that the proposed scheme provides quite accurate results which demonstrate complete protection scheme with high accuracy, simplicity and robustness.

Prodigious submarine landslides during the inception and early growth of volcanic islands.

PubMed

Hunt, James E; Jarvis, Ian

2017-12-12

Volcanic island inception applies large stresses as the ocean crust domes in response to magma ascension and is loaded by eruption of lavas. There is currently limited information on when volcanic islands are initiated on the seafloor, and no information regarding the seafloor instabilities island inception may cause. The deep sea Madeira Abyssal Plain contains a 43 million year history of turbidites among which many originate from mass movements in the Canary Islands. Here, we investigate the composition and timing of a distinctive group of turbidites that we suggest represent a new unique record of large-volume submarine landslides triggered during the inception, submarine shield growth, and final subaerial emergence of the Canary Islands. These slides are predominantly multi-stage and yet represent among the largest mass movements on the Earth's surface up to three or more-times larger than subaerial Canary Islands flank collapses. Thus whilst these deposits provide invaluable information on ocean island geodynamics they also represent a significant, and as yet unaccounted, marine geohazard.

Endometrial biomarkers for the non-invasive diagnosis of endometriosis.

PubMed

Gupta, Devashana; Hull, M Louise; Fraser, Ian; Miller, Laura; Bossuyt, Patrick M M; Johnson, Neil; Nisenblat, Vicki

2016-04-20

About 10% of reproductive-aged women suffer from endometriosis, which is a costly, chronic disease that causes pelvic pain and subfertility. Laparoscopy is the gold standard diagnostic test for endometriosis, but it is expensive and carries surgical risks. Currently, there are no non-invasive tests available in clinical practice that accurately diagnose endometriosis. This is the first diagnostic test accuracy review of endometrial biomarkers for endometriosis that utilises Cochrane methodologies, providing an update on the rapidly expanding literature in this field. To determine the diagnostic accuracy of the endometrial biomarkers for pelvic endometriosis, using a surgical diagnosis as the reference standard. We evaluated the tests as replacement tests for diagnostic surgery and as triage tests to inform decisions to undertake surgery for endometriosis. We did not restrict the searches to particular study designs, language or publication dates. To identify trials, we searched the following databases: CENTRAL (2015, July), MEDLINE (inception to May 2015), EMBASE (inception to May 2015), CINAHL (inception to April 2015), PsycINFO (inception to April 2015), Web of Science (inception to April 2015), LILACS (inception to April 2015), OAIster (inception to April 2015), TRIP (inception to April 2015) and ClinicalTrials.gov (inception to April 2015). We searched DARE and PubMed databases up to April 2015 to identify reviews and guidelines as sources of references to potentially relevant studies. We also performed searches for papers recently published and not yet indexed in the major databases. The search strategies incorporated words in the title, abstract, text words across the record and the medical subject headings (MeSH). We considered published peer-reviewed, randomised controlled or cross-sectional studies of any size that included prospectively collected samples from any population of reproductive-aged women suspected of having one or more of the following target conditions: ovarian, peritoneal or deep infiltrating endometriosis (DIE). Two authors independently extracted data from each study and performed a quality assessment. For each endometrial diagnostic test, we classified the data as positive or negative for the surgical detection of endometriosis and calculated the estimates of sensitivity and specificity. We considered two or more tests evaluated in the same cohort as separate data sets. We used the bivariate model to obtain pooled estimates of sensitivity and specificity whenever sufficient data were available. The predetermined criteria for a clinically useful test to replace diagnostic surgery was one with a sensitivity of 94% and a specificity of 79%. The criteria for triage tests were set at sensitivity at or above 95% and specificity at or above 50%, which in case of negative results rules out the diagnosis (SnOUT test) or sensitivity at or above 50% with specificity at or above 95%, which in case of positive result rules in the diagnosis (SpIN test). We included 54 studies involving 2729 participants, most of which were of poor methodological quality. The studies evaluated endometrial biomarkers either in specific phases of the menstrual cycle or outside of it, and the studies tested the biomarkers either in menstrual fluid, in whole endometrial tissue or in separate endometrial components. Twenty-seven studies evaluated the diagnostic performance of 22 endometrial biomarkers for endometriosis. These were angiogenesis and growth factors (PROK-1), cell-adhesion molecules (integrins α3β1, α4β1, β1 and α6), DNA-repair molecules (hTERT), endometrial and mitochondrial proteome, hormonal markers (CYP19, 17βHSD2, ER-α, ER-β), inflammatory markers (IL-1R2), myogenic markers (caldesmon, CALD-1), neural markers (PGP 9.5, VIP, CGRP, SP, NPY, NF) and tumour markers (CA-125). Most of these biomarkers were assessed in single studies, whilst only data for PGP 9.5 and CYP19 were available for meta-analysis. These two biomarkers demonstrated significant diversity for the diagnostic estimates between the studies; however, the data were too limited to reliably determine the sources of heterogeneity. The mean sensitivities and specificities of PGP 9.5 (7 studies, 361 women) were 0.96 (95% confidence interval (CI) 0.91 to 1.00) and 0.86 (95% CI 0.70 to 1.00), after excluding one outlier study, and for CYP19 (8 studies, 444 women), they were were 0.77 (95% CI 0.70 to 0.85) and 0.74 (95% CI 0.65 to 84), respectively. We could not statistically evaluate other biomarkers in a meaningful way. An additional 31 studies evaluated 77 biomarkers that showed no evidence of differences in expression levels between the groups of women with and without endometriosis. We could not statistically evaluate most of the biomarkers assessed in this review in a meaningful way. In view of the low quality of most of the included studies, the findings of this review should be interpreted with caution. Although PGP 9.5 met the criteria for a replacement test, it demonstrated considerable inter study heterogeneity in diagnostic estimates, the source of which could not be determined. Several endometrial biomarkers, such as endometrial proteome, 17βHSD2, IL-1R2, caldesmon and other neural markers (VIP, CGRP, SP, NPY and combination of VIP, PGP 9.5 and SP) showed promising evidence of diagnostic accuracy, but there was insufficient or poor quality evidence for any clinical recommendations. Laparoscopy remains the gold standard for the diagnosis of endometriosis, and using any non-invasive tests should only be undertaken in a research setting. We have also identified a number of biomarkers that demonstrated no diagnostic value for endometriosis. We recommend that researchers direct future studies towards biomarkers with high diagnostic potential in good quality diagnostic studies.

Preliminary Assessment of the Flow of Used Electronics, In ...

EPA Pesticide Factsheets

Electronic waste (e-waste) is the largest growing municipal waste stream in the United States. The improper disposal of e-waste has environmental, economic, and social impacts, thus there is a need for sustainable stewardship of electronics. EPA/ORD has been working to improve our understanding of the quantity and flow of electronic devices from initial purchase to final disposition. Understanding the pathways of used electronics from the consumer to their final disposition would provide insight to decision makers about their impacts and support efforts to encourage improvements in policy, technology, and beneficial use. This report is the first stage of study of EPA/ORD's efforts to understand the flows of used electronics and e-waste by reviewing the regulatory programs for the selected states and identifying the key lessons learned and best practices that have emerged since their inception. Additionally, a proof-of-concept e-waste flow model has been developed to provide estimates of the quantity of e-waste generated annually at the national level, as well as for selected states. This report documents a preliminary assessment of available data and development of the model that can be used as a starting point to estimate domestic flows of used electronics from generation, to collection and reuse, to final disposition. The electronics waste flow model can estimate the amount of electronic products entering the EOL management phase based on unit sales dat

Immediate replacement of fishing with dairying by the earliest farmers of the northeast Atlantic archipelagos

PubMed Central

Cramp, Lucy J. E.; Jones, Jennifer; Sheridan, Alison; Smyth, Jessica; Whelton, Helen; Mulville, Jacqui; Sharples, Niall; Evershed, Richard P.

2014-01-01

The appearance of farming, from its inception in the Near East around 12 000 years ago, finally reached the northwestern extremes of Europe by the fourth millennium BC or shortly thereafter. Various models have been invoked to explain the Neolithization of northern Europe; however, resolving these different scenarios has proved problematic due to poor faunal preservation and the lack of specificity achievable for commonly applied proxies. Here, we present new multi-proxy evidence, which qualitatively and quantitatively maps subsistence change in the northeast Atlantic archipelagos from the Late Mesolithic into the Neolithic and beyond. A model involving significant retention of hunter–gatherer–fisher influences was tested against one of the dominant adoptions of farming using a novel suite of lipid biomarkers, including dihydroxy fatty acids, ω-(o-alkylphenyl)alkanoic acids and stable carbon isotope signatures of individual fatty acids preserved in cooking vessels. These new findings, together with archaeozoological and human skeletal collagen bulk stable carbon isotope proxies, unequivocally confirm rejection of marine resources by early farmers coinciding with the adoption of intensive dairy farming. This pattern of Neolithization contrasts markedly to that occurring contemporaneously in the Baltic, suggesting that geographically distinct ecological and cultural influences dictated the evolution of subsistence practices at this critical phase of European prehistory. PMID:24523264

Stability Assessment of a System Comprising a Single Machine and Inverter with Scalable Ratings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Brian B; Lin, Yashen; Gevorgian, Vahan

From the inception of power systems, synchronous machines have acted as the foundation of large-scale electrical infrastructures and their physical properties have formed the cornerstone of system operations. However, power electronics interfaces are playing a growing role as they are the primary interface for several types of renewable energy sources and storage technologies. As the role of power electronics in systems continues to grow, it is crucial to investigate the properties of bulk power systems in low inertia settings. In this paper, we assess the properties of coupled machine-inverter systems by studying an elementary system comprised of a synchronous generator,more » three-phase inverter, and a load. Furthermore, the inverter model is formulated such that its power rating can be scaled continuously across power levels while preserving its closed-loop response. Accordingly, the properties of the machine-inverter system can be assessed for varying ratios of machine-to-inverter power ratings and, hence, differing levels of inertia. After linearizing the model and assessing its eigenvalues, we show that system stability is highly dependent on the interaction between the inverter current controller and machine exciter, thus uncovering a key concern with mixed machine-inverter systems and motivating the need for next-generation grid-stabilizing inverter controls.« less

Maritime Domain Awareness Risk Reduction Limited Objective Experiment

DTIC Science & Technology

2008-07-01

Catheryn Maru Ship-2: Patrick Angel Ship-3: YM Inception Expected Operator Actions – Three new vessels are added to the VOI watch list. Both...1: Catheryn Maru Ship-2: Patrick Angel Ship-3: YM Inception Expected Operator Actions – Three new vessels are added to the VOI watch list

The Newest Offering in the Higher Education Leadership Movement: A Model Campus-Wide Residential Program for Faculty and Staff

ERIC Educational Resources Information Center

Scott, Susan M.; Tolar, Mary Hale

2009-01-01

In recent decades, leadership scholars have bemoaned the lack of true leaders and leadership education at all levels and issued the fabled "cry for leadership." Although institutions of higher learning have been engaged in guiding the leaders of society since their inception, they offered no formalized programs or courses until relatively…

Middle School Teacher Satisfaction with Response to Intervention (RtI): An Assessment between Inception and Implementation

ERIC Educational Resources Information Center

Zahedi, Karynn Jensen

2010-01-01

Response to intervention (RtI) is a multi-tiered process of monitoring student responses to remediation that is designed to help struggling learners succeed within the purview of regular education. Under the RtI model, students are referred to special education only after a series of documented interventions have been attempted. This study…

National Combustion Code: Parallel Performance

NASA Technical Reports Server (NTRS)

Babrauckas, Theresa

2001-01-01

This report discusses the National Combustion Code (NCC). The NCC is an integrated system of codes for the design and analysis of combustion systems. The advanced features of the NCC meet designers' requirements for model accuracy and turn-around time. The fundamental features at the inception of the NCC were parallel processing and unstructured mesh. The design and performance of the NCC are discussed.

A Historical Perspective on the University of California, Santa Cruz 1965-2005

ERIC Educational Resources Information Center

Rogers, Lynda M.

2011-01-01

Purpose: The purpose of this study was to trace the organizational history of the University of California Santa Cruz from its inception in 1965 to its 40th anniversary in 2005. The study investigated the original vision of small residential colleges as modeled after the Oxford University plan. The study chronicled the critical turning points of…

Dielectric Characteristics of Oil filled Transformer under Non-standard Lightning Surge Waveforms

NASA Astrophysics Data System (ADS)

Okabe, Shigemitsu; Kawashima, Takeshi; Inoue, Tamotsu; Teranishi, Tsuneharu; Nagaoka, Satoshi

To achieve a rational insulation design for transformers, it is important to evaluate dielectric strength against actually impinging on equipment on-site This paper deals with the dielectric characteristics of a turn-to-turn insulation model for oil filled transformer under non-standard lightning surge waveforms combined with oscillatory voltage. As the results‚ the breakdown voltages and the partial discharge inception voltages of a turn-to-turn insulation model under non-standard impulse wave forms are higher than standard impulse voltages.

Raether-Meek criterion for prediction of electrodeless discharge inception on a dielectric surface in different gases

NASA Astrophysics Data System (ADS)

Chvyreva, A.; Pancheshnyi, S.; Christen, T.; Pemen, A. J. M.

2018-03-01

Electrodeless streamer inception on an epoxy surface under AC voltage stress was investigated for different gas compositions and pressures, with a focus on the pressure region below 1 bar. For this purpose, we used a set-up with cylindrical electrodes embedded out-of-axis in a cylindrical epoxy rod. Experiments were performed in N2, SF6, ambient air, Ar and CO2. The discharge inception voltage was measured, from which the critical value K of the ionization integral was reconstructed assuming a non-disturbed Laplacian field distribution. We have validated that for electropositive gases Ar an N2 the generally assumed value of K  =  10 is in good agreement with our measurements. For electronegative gases, however, the experimentally obtained values turned out to be considerably higher. We attribute this discrepancy mainly to the statistical time delay of the first electron; to increase the probability of discharge inception in a critical region, it was necessary to extend the critical area by means of applying an overvoltage to the system.

Advances in asthma 2015: Across the lifespan.

PubMed

Liu, Andrew H; Anderson, William C; Dutmer, Cullen M; Searing, Daniel A; Szefler, Stanley J

2016-08-01

In 2015, progress in understanding asthma ranged from insights to asthma inception, exacerbations, and severity to advancements that will improve disease management throughout the lifespan. 2015's insights to asthma inception included how the intestinal microbiome affects asthma expression with the identification of specific gastrointestinal bacterial taxa in early infancy associated with less asthma risk, possibly by promoting regulatory immune development at a critical early age. The relevance of epigenetic mechanisms in regulating asthma-related gene expression was strengthened. Predicting and preventing exacerbations throughout life might help to reduce progressive lung function decrease and disease severity in adulthood. Although allergy has long been linked to asthma exacerbations, a mechanism through which IgE impairs rhinovirus immunity and underlies asthma exacerbations was demonstrated and improved by anti-IgE therapy (omalizumab). Other key molecular pathways underlying asthma exacerbations, such as cadherin-related family member 3 (CDHR3) and orosomucoid like 3 (ORMDL3), were elucidated. New anti-IL-5 therapeutics, mepolizumab and reslizumab, were US Food and Drug Administration approved for the treatment of patients with severe eosinophilic asthma. In a clinical trial the novel therapeutic inhaled GATA3 mRNA-specific DNAzyme attenuated early- and late-phase allergic responses to inhaled allergen. These current findings are significant steps toward addressing unmet needs in asthma prevention, severity modification, disparities, and lifespan outcomes. Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Can Rheumatologists Predict Eventual Need for Orthopaedic Intervention in Patients with Rheumatoid Arthritis? Results of a Systematic Review and Analysis of Two UK Inception Cohorts.

PubMed

Nikiphorou, Elena; Carpenter, Lewis; Norton, Sam; Morris, Stephen; MacGregor, Alex; Dixey, Josh; Williams, Peter; Kiely, Patrick; Walsh, David Andrew; Young, Adam

2017-03-01

The structural damage caused by rheumatoid arthritis (RA) can often be mitigated by orthopaedic surgery in late disease. This study evaluates the value of predictive factors for orthopaedic intervention. A systematic review of literature was undertaken to identify papers describing predictive factors for orthopaedic surgery in RA. Manuscripts were selected if they met inclusion criteria of cohort study design, diagnosis of RA, follow-up duration/disease duration ≥3 years, any orthopaedic surgical interventions recorded, and then summarised for predictive factors. A separate predictive analysis was performed on two consecutive UK Early RA cohorts, linked to national datasets. The literature search identified 15 reports examining predictive factors for orthopaedic intervention, 4 inception, 5 prospective and 6 retrospective. Despite considerable variation, acute phase, x-ray scores, women and genotyping were the most commonly reported prognostic markers. The current predictive analysis included 1602 procedures performed in 711 patients (25-year cumulative incidence 26%). Earlier recruitment year, erosions and lower haemoglobin predicted both intermediate and major surgery (P<0.05). Studies report variations in type of and predictive power of clinical and laboratory parameters for different surgical interventions suggesting specific contributions from different pathological and/or patient-level factors. Our current analysis suggests that attention to non-inflammatory factors in addition to suppression of inflammation is needed to minimise the burden of orthopaedic surgery.

Analytical Tools for Affordability Analysis

DTIC Science & Technology

2015-04-30

flunk this basic test from their inception. —Honorable Ashton B. Carter (2010), Under Secretary of Defense for Acquisition, Technology, and Logistics... Testing , and Evaluation] funding has been lost to cancelled programs. (Decker & Wagner, 2011) The Army is scarcely unique in this regard. All... econometric model of how schedule affects cost should take advantage of these different cost categories and treat them separately when they are known

The Development and Diffusion of the Training and Technology Program: A Decade of Development of Manpower Training, 1965-1975. Final Report.

ERIC Educational Resources Information Center

Demik, Gary H.; And Others

The report describes the development of a model training program, Training and Technology, and subsequent efforts to diffuse the innovation. Before the inception of TAT, a survey study, Resources for Southern Manpower Development, had indicated that the South had considerable manpower development potential and need. TAT was organized by Oak Ridge…

Ship Model Testing

DTIC Science & Technology

2016-01-15

state-of-the-art equipment and to continue to produce excellent graduates in our field. Technical Approach In order to address our current testing ...New Additions • New material testing machine with environmental chamber • New dual-fuel test bed for Haeberle Laboratory • Upgrade existing...Southwark Emery universal test machine • 3D printer with ultra-high surface definition • CFD Workstations Since the inception of this grant, Webb

The Life and Times of a Learning Technology System: The Impact of Change and Evolution

ERIC Educational Resources Information Center

Pahl, Claus

2013-01-01

With the inception of the web now being more than 20 years ago, many web-based learning technology systems (LTS) have had a long life and have undergone many changes, both affecting content and infrastructure technologies. A change factor model can capture the various factors causing LTS to change. Methods for change-aware design of LTS have been…

Inception and Early Evolution of the Aleutian Arc

NASA Astrophysics Data System (ADS)

Bezard, R.; Hoernle, K.; Hauff, F.; Portnyagin, M.; Werner, R.; Yogodzinski, G.; Jicha, B.; Garbe-Schönberg, D.; Turner, S.; Schaefer, B. F.

2017-12-01

Constraining the timing and style of subduction initiation in the Aleutian system is critical to model the Cenozoic geodynamic evolution of the Pacific. Until now, the oldest ages for the Aleutian arc suggest a subduction inception at c.a. 46-47 Ma. However, the compositions of these samples (arc tholeiites and calc-alkaline rocks) are different from those of typical early-arc sequences found at extensively studied subduction systems (Izu-Bonin-Mariana), dominated by FABs and boninites. Thus, if the FAB/boninite model applies to the Aleutian, the oldest units might not have been recovered yet and the arc inception could have occurred earlier than 47 Ma. To test this hypothesis, we have sampled the lowermost submarine Aleutian sequences at ten forearc and rear-arc localities during the R/V SONNE Cruise 249. We present preliminary whole-rock major and trace element concentrations, Sr-Nd-Hf-Pb isotopes as well as U-Pb zircon dating on the recovered igneous rocks. The sample compositions range from tholeiitic to calc-alkaline. No boninites were found. Most of the samples show strong subduction signatures. However, the remaining rocks present no or minor arc-type trace element features. These samples are either depleted tholeiites with similar trace element characteristics to FABs or enriched calc-alkaline rocks. Preliminary zircon dating suggests an age of 47.2 ± 1.2 Ma for one of the samples with strong arc signatures, consistent with the oldest published ages for the Aleutian so far. However, based on their compositional similarities to FABs, the depleted tholeiites should be older than the arc-type rocks, suggesting that subduction initiation could have occurred earlier than the above-mentioned age. The absence of boninite could either reflect an incomplete sampling of the early-arc sequences or a different initiation style compared to other Pacific subduction zones. Further ages and radiogenic isotope data should refine these interpretations.

Automatic white blood cell classification using pre-trained deep learning models: ResNet and Inception

NASA Astrophysics Data System (ADS)

Habibzadeh, Mehdi; Jannesari, Mahboobeh; Rezaei, Zahra; Baharvand, Hossein; Totonchi, Mehdi

2018-04-01

This works gives an account of evaluation of white blood cell differential counts via computer aided diagnosis (CAD) system and hematology rules. Leukocytes, also called white blood cells (WBCs) play main role of the immune system. Leukocyte is responsible for phagocytosis and immunity and therefore in defense against infection involving the fatal diseases incidence and mortality related issues. Admittedly, microscopic examination of blood samples is a time consuming, expensive and error-prone task. A manual diagnosis would search for specific Leukocytes and number abnormalities in the blood slides while complete blood count (CBC) examination is performed. Complications may arise from the large number of varying samples including different types of Leukocytes, related sub-types and concentration in blood, which makes the analysis prone to human error. This process can be automated by computerized techniques which are more reliable and economical. In essence, we seek to determine a fast, accurate mechanism for classification and gather information about distribution of white blood evidences which may help to diagnose the degree of any abnormalities during CBC test. In this work, we consider the problem of pre-processing and supervised classification of white blood cells into their four primary types including Neutrophils, Eosinophils, Lymphocytes, and Monocytes using a consecutive proposed deep learning framework. For first step, this research proposes three consecutive pre-processing calculations namely are color distortion; bounding box distortion (crop) and image flipping mirroring. In second phase, white blood cell recognition performed with hierarchy topological feature extraction using Inception and ResNet architectures. Finally, the results obtained from the preliminary analysis of cell classification with (11200) training samples and 1244 white blood cells evaluation data set are presented in confusion matrices and interpreted using accuracy rate, and false positive with the classification framework being validated with experiments conducted on poor quality blood images sized 320 × 240 pixels. The deferential outcomes in the challenging cell detection task, as shown in result section, indicate that there is a significant achievement in using Inception and ResNet architecture with proposed settings. Our framework detects on average 100% of the four main white blood cell types using ResNet V1 50 while also alternative promising result with 99.84% and 99.46% accuracy rate obtained with ResNet V1 152 and ResNet 101, respectively with 3000 epochs and fine-tuning all layers. Further statistical confusion matrix tests revealed that this work achieved 1, 0.9979, 0.9989 sensitivity values when area under the curve (AUC) scores above 1, 0.9992, 0.9833 on three proposed techniques. In addition, current work shows negligible and small false negative 0, 2, 1 and substantial false positive with 0, 0, 5 values in Leukocytes detection.

Inception of self-interacting dark matter with dark charge conjugation symmetry

DOE PAGES

Ma, Ernest

2017-07-04

A new understanding of the stability of self-interacting dark matter is pointed out, based on the simplest spontaneously broken Abelian gauge model with one complex scalar and one Dirac fermion. The key is the imposition of dark charge conjugation symmetry. It allows the possible existence of two stable particles: the Dirac fermion and the vector gauge boson which acts as a light mediator for the former's self-interaction. Since this light mediator does not decay, it avoids the strong cosmological constraints recently obtained for all such models where the light mediator decays into standard-model particles.

Pain-Relieving Interventions for Retinopathy of Prematurity: A Meta-analysis.

PubMed

Disher, Timothy; Cameron, Chris; Mitra, Souvik; Cathcart, Kelcey; Campbell-Yeo, Marsha

2018-06-01

Retinopathy of prematurity eye examinations conducted in the neonatal intensive care. To combine randomized trials of pain-relieving interventions for retinopathy of prematurity examinations using network meta-analysis. Systematic review and network meta-analysis of Medline, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and the World Health Organization International Clinical Trials Registry Platform. All databases were searched from inception to February 2017. Abstract and title screen and full-text screening were conducted independently by 2 reviewers. Data were extracted by 2 reviewers and pooled with random effect models if the number of trials within a comparison was sufficient. The primary outcome was pain during the examination period; secondary outcomes were pain after the examination, physiologic response, and adverse events. Twenty-nine studies ( N = 1487) were included. Topical anesthetic (TA) combined with sweet taste and an adjunct intervention (eg, nonnutritive sucking) had the highest probability of being the optimal treatment (mean difference [95% credible interval] versus TA alone = -3.67 [-5.86 to -1.47]; surface under the cumulative ranking curve = 0.86). Secondary outcomes were sparsely reported (2-4 studies, N = 90-248) but supported sweet-tasting solutions with or without adjunct interventions as optimal. Limitations included moderate heterogeneity in pain assessment reactivity phase and severe heterogeneity in the regulation phase. Multisensory interventions including sweet taste is likely the optimal treatment for reducing pain resulting from eye examinations in preterm infants. No interventions were effective in absolute terms. Copyright © 2018 by the American Academy of Pediatrics.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dong, B.; Valdes, P.J.

The U.K. University Global Atmospheric Modeling Programme GCM is used to investigate whether the growth of Northern Hemisphere ice sheets could have been initiated by changes of orbital parameters and sea surface temperatures. Two different orbital configurations, corresponding to the present day and 115 kyr BP are used. The reduced summer solar insolation in the Northern Hemisphere results in a decrease of the surface temperature by 4{degrees} to 10{degrees}C in the northern continents and to perennial snow in some high-latitude regions. Therefore, the model results support the hypothesis that a deficit of summer insolation can create conditions favorable for initiationmore » of ice sheet growth in the Northern Hemisphere. A decreased sea surface temperature northward of 65{degrees}N during the Northern Hemisphere summer may contribute to the maintenance of ice sheets. A simple mixed-layer ocean model coupled to the GCM indicates that the changes of sea surface temperature and extension of sea ice due to insolation changes play an important role in inception of the Fennoscandian, Laurentide, and Cordilleran ice sheets. The model results suggest that the regions of greatest sensitivity for ice initiation are the Canadian Archipelago, Baffin Island, Tibetan Plateau, Scandinavia, Siberia, Alaska, and Keewatin, where changing orbital parameters to 115 kyr BP results in the snow cover remaining throughout the warmer summer, leading to long-term snow accumulation. The model results are in general agreement with geological evidence and are the first time that a GCM coupled with a mixed layer ocean has reproduced the inception of the Northern Hemisphere ice sheets. 69 refs., 21 figs., 3 tabs.« less

The Pliocene-Pleistocene transition and the onset of the Northern Hemisphere glacial inception

NASA Astrophysics Data System (ADS)

Robinson, A.; Calov, R.; Ganopolski, A.

2011-12-01

The Pliocene-Pleistocene transition (PPT, ca. 3.3-2.4 Ma BP) marks a shift in the Earth's climate and is believed to coincide with the inception of the Northern Hemisphere (NH) ice sheets. This transition is not only characterized by a gradual reduction in atmospheric CO2 concentration, paleo records also show a strengthening in the amplitude of δ18O data and intensified ice rafted debris deposition in the North Atlantic. Previous modeling studies have demonstrated that the drop in atmospheric CO2 plays an important role in the glaciation of the NH ice sheets, and more specifically, it is considered to be the primary cause of the glaciation of Greenland. Here we apply a novel approach to produce transient simulations of the entire PPT, in order to study the glaciation of Greenland and the NH ice sheets and additionally, to investigate which conditions are necessary for full-scale glaciation. The fully-coupled Earth system model of intermediate complexity CLIMBER-2 is used to explore the effects of a suite of orbital and CO2 forcing scenarios on total NH glaciation. CLIMBER-2 includes low-resolution sub-models of the atmosphere, vegetation, ocean and ice sheets - the latter is designed to simulate the big NH ice sheets with a rather low resolution (and high computational efficiency). As a refinement, the results of the global simulations are then used to force regional simulations of the Greenland Ice Sheet (GIS) using the higher resolution (20 km) regional climate-ice sheet model, REMBO-SICOPOLIS. We present results of transient simulations driven by orbital forcing and several CO2 reduction scenarios that are consistent with best estimates from data for this time period. We discuss the growth and persistence of the NH ice sheets in terms of the forcing and feedbacks involved. Additionally, we present a set of simulations with the growth of the NH ice sheets disabled, in order to quantify the effect the large ice sheets have on global and regional temperature anomalies. By simulating the Greenland Ice Sheet (GIS) in our high resolution coupled global-regional approach, we identify with greater precision, the conditions neccesary for inception of the GIS and link these to global climatic changes.

The Foundation and Development of Computer Assisted Instruction in the Field of Reading from Its Inception to the Present.

ERIC Educational Resources Information Center

Zuberman, Lea K.

This critical review and evaluation of the literature covers the field of computer assisted instruction (CAI) and reading from its inception to the present day. Seventeen research studies are discussed as well as four surveys of previous research in this field. Major issues addressed include the effectiveness of CAI and computer managed…

It's up to you: a multi-message, phased driver facility campaign to increase organ donation registration rates in Illinois.

PubMed

Quick, Brian; Harrison, Tyler R; King, Andy J; Bosch, Dave

2013-01-01

The present project applied successful strategies employed in previous driver facility campaigns occurring during the inception of a registry to examine whether these approaches are effective in growing a mature registry, a registry where the majority of individuals have had the opportunity to register as an organ donor. Driver facilities (N = 40) in Illinois with high (n = 20) and low (n = 20) organ donation registration percentages were selected and served as either intervention or control sites for the campaign. Among facilities with historically high and low registration percentages, support for the campaign was found with the intervention facilities experiencing higher organ donation registration rates compared with control facilities. In addition, the results provide partial support for the effectiveness of employing a multi-message, phased driver facility intervention in states with a mature registry. The practical implications of utilizing driver facility campaigns in states with an established first-person consent registry also are discussed. © 2013 John Wiley & Sons A/S.

Learning for Older Adults in Portugal: Universities of the Third Age in a State of Change

ERIC Educational Resources Information Center

Costa Veloso, Esmeraldina

2017-01-01

U3As have their origin in 1973 in Toulouse, France, with Professor Pierre Vellas. This French influence was also felt in Portugal and the first Portuguese U3A opened its doors also in the 1970's. However, from inception the Portuguese reality was very different from the French model, especially in regards to its promoters. However, both in France…

Response to Intervention: An Examination of the Impact of the Model in Increasing the Reading Fluency Levels for Third and Fourth Grade At-Risk Learners

ERIC Educational Resources Information Center

Haughton-Williams, Judith

2009-01-01

Since the inception of the Individual with Disabilities Education Act (IDEA) of 1975, an increasing percentage of children between the ages of 3-21 have been identified as students with learning disabilities (LD). Reports from the National Center of Learning Disabilities (2000) have suggested that monitoring of student learning is frequently…

Army-NASA aircrew/aircraft integration program. Phase 5: A3I Man-Machine Integration Design and Analysis System (MIDAS) software concept document

NASA Technical Reports Server (NTRS)

Banda, Carolyn; Bushnell, David; Chen, Scott; Chiu, Alex; Neukom, Christian; Nishimura, Sayuri; Prevost, Michael; Shankar, Renuka; Staveland, Lowell; Smith, Greg

1992-01-01

This is the Software Concept Document for the Man-machine Integration Design and Analysis System (MIDAS) being developed as part of Phase V of the Army-NASA Aircrew/Aircraft Integration (A3I) Progam. The approach taken in this program since its inception in 1984 is that of incremental development with clearly defined phases. Phase 1 began in 1984 and subsequent phases have progressed at approximately 10-16 month intervals. Each phase of development consists of planning, setting requirements, preliminary design, detailed design, implementation, testing, demonstration and documentation. Phase 5 began with an off-site planning meeting in November, 1990. It is expected that Phase 5 development will be complete and ready for demonstration to invited visitors from industry, government and academia in May, 1992. This document, produced during the preliminary design period of Phase 5, is intended to record the top level design concept for MIDAS as it is currently conceived. This document has two main objectives: (1) to inform interested readers of the goals of the MIDAS Phase 5 development period, and (2) to serve as the initial version of the MIDAS design document which will be continuously updated as the design evolves. Since this document is written fairly early in the design period, many design issues still remain unresolved. Some of the unresolved issues are mentioned later in this document in the sections on specific components. Readers are cautioned that this is not a final design document and that, as the design of MIDAS matures, some of the design ideas recorded in this document will change. The final design will be documented in a detailed design document published after the demonstrations.

Lessons Learned from the Puerto Rico Battery Energy Storage System

DOE Office of Scientific and Technical Information (OSTI.GOV)

BOYES, JOHN D.; DE ANA, MINDI FARBER; TORRES, WENCESLANO

1999-09-01

The Puerto Rico Electric Power Authority (PREPA) installed a distributed battery energy storage system in 1994 at a substation near San Juan, Puerto Rico. It was patterned after two other large energy storage systems operated by electric utilities in California and Germany. The U.S. Department of Energy (DOE) Energy Storage Systems Program at Sandia National Laboratories has followed the progress of all stages of the project since its inception. It directly supported the critical battery room cooling system design by conducting laboratory thermal testing of a scale model of the battery under simulated operating conditions. The Puerto Rico facility ismore » at present the largest operating battery storage system in the world and is successfully providing frequency control, voltage regulation, and spinning reserve to the Caribbean island. The system further proved its usefulness to the PREPA network in the fall of 1998 in the aftermath of Hurricane Georges. The owner-operator, PREPA, and the architect/engineer, vendors, and contractors learned many valuable lessons during all phases of project development and operation. In documenting these lessons, this report will help PREPA and other utilities in planning to build large energy storage systems.« less

Remodeling of the Infection Chamber before Infection Thread Formation Reveals a Two-Step Mechanism for Rhizobial Entry into the Host Legume Root Hair1

PubMed Central

Teillet, Alice; Chabaud, Mireille; Ivanov, Sergey; Genre, Andrea; Limpens, Erik; de Carvalho-Niebel, Fernanda; Barker, David G.

2015-01-01

In many legumes, root entry of symbiotic nitrogen-fixing rhizobia occurs via host-constructed tubular tip-growing structures known as infection threads (ITs). Here, we have used a confocal microscopy live-tissue imaging approach to investigate early stages of IT formation in Medicago truncatula root hairs (RHs) expressing fluorescent protein fusion reporters. This has revealed that ITs only initiate 10 to 20 h after the completion of RH curling, by which time major modifications have occurred within the so-called infection chamber, the site of bacterial entrapment. These include the accumulation of exocytosis (M. truncatula Vesicle-Associated Membrane Protein721e)- and cell wall (M. truncatula EARLY NODULIN11)-associated markers, concomitant with radial expansion of the chamber. Significantly, the infection-defective M. truncatula nodule inception-1 mutant is unable to create a functional infection chamber. This underlines the importance of the NIN-dependent phase of host cell wall remodeling that accompanies bacterial proliferation and precedes IT formation, and leads us to propose a two-step model for rhizobial infection initiation in legume RHs. PMID:25659382

Transcranial amelioration of inflammation and cell death after brain injury

NASA Astrophysics Data System (ADS)

Roth, Theodore L.; Nayak, Debasis; Atanasijevic, Tatjana; Koretsky, Alan P.; Latour, Lawrence L.; McGavern, Dorian B.

2014-01-01

Traumatic brain injury (TBI) is increasingly appreciated to be highly prevalent and deleterious to neurological function. At present, no effective treatment options are available, and little is known about the complex cellular response to TBI during its acute phase. To gain insights into TBI pathogenesis, we developed a novel murine closed-skull brain injury model that mirrors some pathological features associated with mild TBI in humans and used long-term intravital microscopy to study the dynamics of the injury response from its inception. Here we demonstrate that acute brain injury induces vascular damage, meningeal cell death, and the generation of reactive oxygen species (ROS) that ultimately breach the glial limitans and promote spread of the injury into the parenchyma. In response, the brain elicits a neuroprotective, purinergic-receptor-dependent inflammatory response characterized by meningeal neutrophil swarming and microglial reconstitution of the damaged glial limitans. We also show that the skull bone is permeable to small-molecular-weight compounds, and use this delivery route to modulate inflammation and therapeutically ameliorate brain injury through transcranial administration of the ROS scavenger, glutathione. Our results shed light on the acute cellular response to TBI and provide a means to locally deliver therapeutic compounds to the site of injury.

Coupled ice sheet - climate simulations of the last glacial inception and last glacial maximum with a model of intermediate complexity that includes a dynamical downscaling of heat and moisture

NASA Astrophysics Data System (ADS)

Quiquet, Aurélien; Roche, Didier M.

2017-04-01

Comprehensive fully coupled ice sheet - climate models allowing for multi-millenia transient simulations are becoming available. They represent powerful tools to investigate ice sheet - climate interactions during the repeated retreats and advances of continental ice sheets of the Pleistocene. However, in such models, most of the time, the spatial resolution of the ice sheet model is one order of magnitude lower than the one of the atmospheric model. As such, orography-induced precipitation is only poorly represented. In this work, we briefly present the most recent improvements of the ice sheet - climate coupling within the model of intermediate complexity iLOVECLIM. On the one hand, from the native atmospheric resolution (T21), we have included a dynamical downscaling of heat and moisture at the ice sheet model resolution (40 km x 40 km). This downscaling accounts for feedbacks of sub-grid precipitation on large scale energy and water budgets. From the sub-grid atmospheric variables, we compute an ice sheet surface mass balance required by the ice sheet model. On the other hand, we also explicitly use oceanic temperatures to compute sub-shelf melting at a given depth. Based on palaeo evidences for rate of change of eustatic sea level, we discuss the capability of our new model to correctly simulate the last glacial inception ( 116 kaBP) and the ice volume of the last glacial maximum ( 21 kaBP). We show that the model performs well in certain areas (e.g. Canadian archipelago) but some model biases are consistent over time periods (e.g. Kara-Barents sector). We explore various model sensitivities (e.g. initial state, vegetation, albedo) and we discuss the importance of the downscaling of precipitation for ice nucleation over elevated area and for the surface mass balance of larger ice sheets.

An Approach to Understanding Psychotronics

DTIC Science & Technology

1976-06-01

a biological system, psi, consciousness, inception, telepathy psychokinesis, UFO’s, God, and the collective unconscious can be taken. Materialization...consciousness, inception, telepathy , tpsychkinesis, UFO’s,, God, and the collective unconscious can be taken. Materialization, demat rializaticn, and...8217the first three laws, then the four law system is indeed closed, and the logician’s dream of a closed metalogic is realized. Further, anything which

"Quest for Success": The Micro-Politics Associated with the Inception and Development of a Secondary School Sport Academy

ERIC Educational Resources Information Center

Rogers, Hamish; Cassidy, Tania

2015-01-01

Over the past 15 years there has been an increase in the number of secondary schools in New Zealand developing sports academies, yet there has not been a corresponding increase in the critical or empirical research investigating this phenomenon. The purpose of this article is to describe the micro-politics associated with the inception and…

Cavitation Inception in Separated Flows.

DTIC Science & Technology

1981-12-01

measured data. Keller (1972, 1973) determined the nuclei population by using a single particle light scattering device (the sample volume was... computations of the average pressure coefficient. The amount of air dissolved in the water varied from 10 to 11 ppm ( molar ) and was measured with a Van Slyke...fluctuating pressures were also measured. .-The conditions for cavitation inception and desinence were determined and several holograms were recorded

Residual Force Enhancement in Humans: A Systematic Review.

PubMed

Chapman, Neil; Whitting, John; Broadbent, Suzanne; Crowley-McHattan, Zachary; Meir, Rudi

2018-06-01

A systematic literature search was conducted to review the evidence of residual force enhancement (RFE) in vivo human muscle. The search, adhered to the PRISMA statement, of CINAHL, EBSCO, Embase, MEDLINE, and Scopus (inception-July 2017) was conducted. Full-text English articles that assessed at least 1 measure of RFE in vivo voluntarily contracted human skeletal muscle were selected. The methodologies of included articles were assessed against the Downs and Black checklist. Twenty-four studies were included (N = 424). Pooled Downs and Black scores ranked "fair" ([Formula: see text] [2.26]). RFE was observed in all muscles tested. Joint range of motion varied from 15° to 60°. Contraction intensities ranged from 10% to >95% maximum. Although transient force enhancement during the stretch phase may change with angular velocity, RFE in the subsequent isometric phase is independent of velocity. The magnitude of RFE was influenced by smaller stretch amplitudes and greatest at joint angles indicative of longer muscle lengths. Contraction and activation intensity influenced RFE, particularly during the initial isometric contraction phase of a poststretch isometric contraction. RFE resulted in increased torque production, reduced muscular activation, and enhanced torque production when the neuromuscular system is weakened seen in an aged population.

Hydroelastic behaviour of a structure exposed to an underwater explosion

PubMed Central

Colicchio, G.; Greco, M.; Brocchini, M.; Faltinsen, O. M.

2015-01-01

The hydroelastic interaction between an underwater explosion and an elastic plate is investigated num- erically through a domain-decomposition strategy. The three-dimensional features of the problem require a large computational effort, which is reduced through a weak coupling between a one-dimensional radial blast solver, which resolves the blast evolution far from the boundaries, and a three-dimensional compressible flow solver used where the interactions between the compression wave and the boundaries take place and the flow becomes three-dimensional. The three-dimensional flow solver at the boundaries is directly coupled with a modal structural solver that models the response of the solid boundaries like elastic plates. This enables one to simulate the fluid–structure interaction as a strong coupling, in order to capture hydroelastic effects. The method has been applied to the experimental case of Hung et al. (2005 Int. J. Impact Eng. 31, 151–168 (doi:10.1016/j.ijimpeng.2003.10.039)) with explosion and structure sufficiently far from other boundaries and successfully validated in terms of the evolution of the acceleration induced on the plate. It was also used to investigate the interaction of an underwater explosion with the bottom of a close-by ship modelled as an orthotropic plate. In the application, the acoustic phase of the fluid–structure interaction is examined, highlighting the need of the fluid–structure coupling to capture correctly the possible inception of cavitation. PMID:25512585

Guiding principles of value creation through collaborative innovation in pharmaceutical research.

PubMed

Schweizer, Liang; He, Jeff

2018-02-01

Open innovation has become the main trend in pharmaceutical research. Potential obstacles and pitfalls of collaborations often lead to missed opportunities and/or poorly executed partnerships. This paper aims to provide a framework that facilitates the execution of successful collaborations. We start by mapping out three checkpoints onto early-stage collaborative partnerships: inception, ignition and implementation. Different value types and value drivers are then laid out for each phase of the partnership. We proceed to propose a ratio-driven approach and a value-adjustment mechanism, enhancing the probability of successes in pharmaceutical research collaborations. These guiding principles combined should help the partners either reach agreement more quickly or move on to the next potential project. Copyright © 2017 Elsevier Ltd. All rights reserved.

Effects of Structure and Hydrodynamics on the Sooting Behavior of Spherical Microgravity Diffusion Flames

NASA Technical Reports Server (NTRS)

Sunderland, P. B.; Axelbaum, R. L.; Urban, D. L.

1999-01-01

Recent experimental, numerical and analytical work has shown that the stoichiometric mixture fraction (Z(sub st)) can have a profound effect on soot formation in diffusion flames. These findings were obtained at constant flame temperature (T(sub ad)), employing the approach described in Du and Axelbaum (1995, 1996). For example, a fuel mixture containing 1 mole of ethylene and 11.28 moles of nitrogen burning in pure oxygen ((Z(sub st)) = 0.78) has the same adiabatic flame temperature (2370 K) as that of pure ethylene burning in air ((Z(sub st)) = 0.064). An important finding of these works was that at sufficiently high (Z(sub st)), flames remain blue as strain rate approaches zero in counterflow flames, or as flame height and residence time approach infinity in coflowing flames. Lin and Faeth (1996a) coined the term permanently blue to describe such flames. Two theories have been proposed to explain the appearance of permanently-blue flames at high (Z(sub st)). They are based on (1) hydrodynamics and (2) flame structure. Previous experimental studies in normal gravity are not definitive as to which, if either, mechanism is dominant because both hydrodynamics and structure suppress soot formation at high (Z(sub st)) in coflowing and counterflowing diffusion flames. In counterflow flames with (Z(sub st)) < 0.5 streamlines at the flame sheet are directed toward the fuel. Newly formed soot is convected into richer regions, favoring soot growth over oxidation. For (Z(sub st)) > 0.5, convection at the flame is toward the oxidizer, thus enhancing soot oxidization. Thus, in counterflow flames, hydrodynamics causes soot to be convected towards the oxidizer at high (Z(sub st)) which suppresses soot formation. Axelbaum and co-workers maintain that while the direction of convection can impact soot growth and oxidation, these processes alone cannot cause permanently-blue flames. Soot growth and oxidation are dependent on the existence of soot particles and the presence of soot is invariably accompanied by yellow luminosity. Soot-particle inception, on the other hand, arises from gas-phase reactions and its dependence on flow direction is weak, similar to that of other gas-phase reactions in flames. For example, when the flame moves across the stagnation plane no significant changes in flame chemistry are observed. Furthermore, since the soot-inception zone has a finite thickness, soot has been produced in counterflow flames with (Z(sub st)) > 0.5. For large (Z(sub st)) the fuel concentration decreases and oxygen concentration increases in the soot forming regions of the flame. This yields a shift in the OH profile toward the fuel side of the flame, and this shift can dramatically influence soot inception because it essentially narrows the soot inception zone. Soot-free (permanently-blue) conditions can be realized when the structure of the flame is adjusted to the extent that significant oxidizing species exist on the fuel side of the flame at temperatures above the critical temperature for soot inception, ca. 1250 K. In previously considered flames it was impossible to independently vary flame structure and convection direction. In contrast, spherical diffusion flames (which generally require microgravity) allow both properties to be varied independently. We altered structure (Z(sub st)) by exchanging inert between the oxidizer and the fuel and we independently varied convection direction at the flame sheet by interchanging the injected and ambient gases. In this work we established four flames: (a) ethylene issuing into air, (b) diluted ethylene issuing into oxygen, (c) air issuing into ethylene, and (d) oxygen issuing into diluted ethylene. (Z(sub st)) is 0.064 in flames (a) and (c) and 0.78 in flames (b) and (d). The convection direction is from fuel to oxidizer in flames (a) and (b) and from oxidizer to fuel in flames (c) and (d). Under the assumption of equal diffusivities of all species and heat, the stoichiometric contours of these flames have identical temperatures and nitrogen concentrations.

Disease fatality and bias in survival cohorts.

PubMed

Barry, Vaughn; Klein, Mitchel; Winquist, Andrea; Darrow, Lyndsey A; Steenland, Kyle

2015-07-01

Simulate how the effect of exposure on disease occurrence and fatality influences the presence and magnitude of bias in survivor cohorts, motivated by an actual survivor cohort under study. We simulated a cohort of 50,000 subjects exposed to a disease-causing exposure over time and followed forty years, where disease incidence was the outcome of interest. We simulated this 'inception' cohort under different assumptions about the effect of exposure on disease occurrence and fatality after disease occurrence. We then created a corresponding 'survivor' (or 'cross-sectional') cohort, where cohort enrollment took place at a specific date after exposure began in the inception cohort; subjects dying prior to that enrollment date were excluded. The disease of interest caused all deaths in our simulations, but was not always fatal. In the survivor cohort, person-time at risk began before enrollment for all subjects who did not die prior to enrollment. We compared exposure-disease associations in each inception cohort to those in corresponding survivor cohorts to determine how different assumptions impacted bias in the survivor cohorts. All subjects in both inception and survivor cohorts were considered equally susceptible to the effect of exposure in causing disease. We used Cox proportional hazards regression to calculate effect measures. There was no bias in survivor cohort estimates when case fatality among diseased subjects was independent of exposure. This was true even when the disease was highly fatal and more highly exposed subjects were more likely to develop disease and die. Assuming a positive exposure-response in the inception cohort, survivor cohort rate ratios were biased downwards when case fatality was greater with higher exposure. Survivor cohort effect estimates for fatal outcomes are not always biased, although precision can decrease. Copyright © 2015 Elsevier Inc. All rights reserved.

Social functioning and socioeconomic changes after introduction of regular dialysis treatment and impact of dialysis modality: a multi-centre survey of Japanese patients.

PubMed

Nakayama, Masaaki; Ishida, Mari; Ogihara, Masahiko; Hanaoka, Kazushige; Tamura, Masahito; Kanai, Hidetoshi; Tonozuka, Yukio; Marshall, Mark R

2015-08-01

Patient socialization and preservation of socioeconomic status are important patient-centred outcomes for those who start dialysis, and retention of employment is a key enabler. This study examined the influence of dialysis inception and modality upon these outcomes in a contemporary Japanese cohort. We conducted a survey of prevalent chronic dialysis patients from 5 dialysis centres in Japan. All patients who had been on peritoneal dialysis (PD) since dialysis inception were recruited, and matched with a sample of those on in-centre haemodialysis (ICHD). We assessed patients' current social functioning (Short Form 36 Health Survey), and evaluated changes to patient employment status, annual income, and general health condition from the pre-dialysis period to the current time. A total of 179 patients were studied (102 PD and 77 ICHD). There were no differences in social functioning by modality. Among them, 113 were employed in the pre-dialysis period with no difference by modality. Of these, 22% became unemployed after dialysis inception, with a corresponding decline in average working hours and annual income. The odds of unemployment after dialysis inception were 5.02 fold higher in those on ICHD compared to those on PD, after adjustment for covariates. There were no changes for those who were already unemployed in the pre-dialysis period. Employment status is significantly hampered by dialysis inception, although PD was associated with superior retention of employment and greater income compared to ICHD. This supports a positive role for PD in preservation of socioeconomic status and potentially other patient-centred outcomes. © 2015 Asian Pacific Society of Nephrology.

Good Governance Matters: Optimizing U.S. PRTs in Afghanistan to Advance Good Governance

DTIC Science & Technology

2009-04-01

a new school. Partnering is critical to ensure the synchronized application of aid. In this case ensuring that teachers ...traces the origins of the U.S. Afghanistan PRT Model from its inception in 2002 to today. The paper will take a critical look at all the three lines...Captain, U.S. Navy A paper submitted to the Faculty of the Joint Advanced Warfighting School in partial satisfaction of the

Flow Characteristics and Status of CFD Hydrodynamic Model Development in Sudden Contraction Manifold/Orifice Configurations

DTIC Science & Technology

2011-07-01

Branching Configuration 33 6.6 CONTRACTION COEFFICIENT 35 7.0 SUPERCAVITATION 36 7.1 FLOW REATTACHMENT 36 7.1.1 In-Line... SUPERCAVITATION 37 7.2.1 In-Line Configuration Critical Cavitation 37 7.2.2 Dead Head Configuration Critical Cavitation 38 7.2.3 Approach...regimes are: (1) Non-Cavitation, (2) Inception of Cavitation, (3) Full Cavitation, (4) Supercavitation , and (5) Hydraulic Flip. The flow

Inception and variability of the Antarctic ice sheet across the Eocene-Oligocene transition

NASA Astrophysics Data System (ADS)

Stocchi, Paolo; Galeotti, Simone; Ladant, Jan-Baptiste; DeConto, Robert; Vermeersen, Bert; Rugenstein, Maria

2014-05-01

Climate cooling throughout middle to late Eocene (~48 - 34 Million years ago, Ma) triggered the transition from hot-house to ice-house conditions. Based on deep-sea marine δ18O values, a continental-scale Antarctic Ice Sheet (AIS) rapidly developed across the Eocene-Oligocene transition (EOT) in two ~200 kyr-spaced phases between 34.0 - 33.5 Ma. Regardless of the geographical configuration of southern ocean gateways, geochemical data and ice-sheet modelling show that AIS glaciation initiated as atmospheric CO2 fell below ~2.5 times pre-industrial values. AIS likely reached or even exceeded present-day dimensions. Quantifying the magnitude and timing of AIS volume variations by means of δ18O records is hampered by the fact that the latter reflect a coupled signal of temperature and ice-sheet volume. Besides, bathymetric variations based on marine geologic sections are affected by large uncertainties and, most importantly, reflect the local response of relative sea level (rsl) to ice volume fluctuations rather than the global eustatic signal. AIS proximal and Northern Hemisphere (NH) marine settings show an opposite trend of rsl change across the EOT. In fact, consistently with central values based on δ18O records, an 60 ± 20m rsl drop is estimated from NH low-latitude shallow marine sequences. Conversely, sedimentary facies from shallow shelfal areas in the proximity of the AIS witness an 50 - 150m rsl rise across the EOT. Accounting for ice-load-induced crustal and geoidal deformations and for the mutual gravitational attraction between the growing AIS and the ocean water is a necessary requirement to reconcile near- and far-field rsl sites, regardless of tectonics and of any other possible local contamination. In this work we investigate the AIS inception and variability across the EOT by combining the observed rsl changes with predictions based on numerical modeling of Glacial Isostatic Adjustment (GIA). We solve the gravitationally self-consistent Sea Level Equation for two different and independent AIS models both driven by atmospheric CO2 variations and evolving on different Antarctic topographies. In particular, minimum and maximum AIS volumes, respectively of ~55m and ~70m equivalent sea level (esl), stem from a smaller and a larger Antarctic topography. Minimum and maximum GIA predictions at the NH rsl sites respectively correspond to the lower limit and central value of the EOT rsl drop inferred from geological data. For both GIA models, the departures from the eustatic trend significantly increase southward toward Antarctica, where the AIS growth is accompanied by a rsl rise. Accordingly, the cyclochronological record of sedimentary cycles retrieved from Cape Roberts Project Drillcore CRP-3 (Victoria Land Basin) witness a deepening across the EOT. Most importantly, CRP-3 record shows that full glacial conditions consistent with the maximum AIS model dimensions were reached only at ~32.8 Ma, while ice-sheet volumes fluctuations around the minimum AIS model volume persisted during the first million years of glaciation.

Synthesis of Graphite Encapsulated Metal Nanoparticles and Metal Catalyzed Nanotubes

NASA Technical Reports Server (NTRS)

vanderWal, R. L.; Dravid, V. P.

1999-01-01

This work focuses on the growth and inception of graphite encapsulated metal nanoparticles and metal catalyzed nanotubes using combustion chemistry. Deciphering the inception and growth mechanism(s) for these unique nanostructures is essential for purposeful synthesis. Detailed knowledge of these mechanism(s) may yield insights into alternative synthesis pathways or provide data on unfavorable conditions. Production of these materials is highly desirable given many promising technological applications.

INCEPTION, DESIGN AND IMPLEMENTATION OF A MANAGEMENT INFORMATION SYSTEM.

DTIC Science & Technology

The purpose of this paper is to develop a uniform systematic approach to the design and implementation of a management information system . In recent...directed towards the design of a management information system . To this end - the creaction of such a document - is this paper dedicated. The...inception to successful implementation of a management information system . Many factors must be considered while applying this procedure, e.g., complexity

Developing a patient-led electronic feedback system for quality and safety within Renal PatientView.

PubMed

Giles, Sally J; Reynolds, Caroline; Heyhoe, Jane; Armitage, Gerry

2017-03-01

It is increasingly acknowledged that patients can provide direct feedback about the quality and safety of their care through patient reporting systems. The aim of this study was to explore the feasibility of patients, healthcare professionals and researchers working in partnership to develop a patient-led quality and safety feedback system within an existing electronic health record (EHR), known as Renal PatientView (RPV). Phase 1 (inception) involved focus groups (n = 9) and phase 2 (requirements) involved cognitive walkthroughs (n = 34) and 1:1 qualitative interviews (n = 34) with patients and healthcare professionals. A Joint Services Expert Panel (JSP) was convened to review the findings from phase 1 and agree the core principles and components of the system prototype. Phase 1 data were analysed using a thematic approach. Data from phase 1 were used to inform the design of the initial system prototype. Phase 2 data were analysed using the components of heuristic evaluation, resulting in a list of core principles and components for the final system prototype. Phase 1 identified four main barriers and facilitators to patients feeding back on quality and safety concerns. In phase 2, the JSP agreed that the system should be based on seven core principles and components. Stakeholders were able to work together to identify core principles and components for an electronic patient quality and safety feedback system in renal services. Tensions arose due to competing priorities, particularly around anonymity and feedback. Careful consideration should be given to the feasibility of integrating a novel element with differing priorities into an established system with existing functions and objectives. © 2016 European Dialysis and Transplant Nurses Association/European Renal Care Association.

Towards Greenland Glaciation: Cumulative or Abrupt Transition?

NASA Astrophysics Data System (ADS)

Tan, N.; Ramstein, G.; Contoux, C.; Ladant, J. B.; Dumas, C.; Donnadieu, Y.

2014-12-01

The insolation evolution [Laskar 2004] from 4 to 2.5 Ma depicts a series of three summer solstice insolation minima between 2.7 and 2.6 Ma, but there are other more important summer solstice minima notably around 3.82 and 3.05 Ma. On such a time span of more than 1 Ma, data shows that there are variations in the evolution of atmospheric CO2 concentration with a local maximum around 3 Ma [Seki et al.2010; Bartoli et al. 2011], before a decrease between 3 and 2.6 Ma. The latter, suggesting an abrupt ice sheet inception around 2.7 Ma, has been shown to be a major culprit for the full Greenland Glaciation [Lunt et al. 2008]. However, a recent study [Contoux et al. 2014, in review] suggests that a lowering of CO2 is not sufficient to initiate a glaciation on Greenland and must be combined to low summer insolation, with surviving ice during insolation maximum, suggesting a cumulative process in the first place, which could further lead to full glaciation at 2.7 Ma. Through a new tri-dimensional interpolation method implemented within the asynchronous coupling between an atmosphere ocean general circulation model (IPSL-CM5A) and an ice sheet model (GRISLI), we investigate the transient evolution of Greenland ice sheet during the Pliocene to diagnose whether the ice sheet inception is an abrupt event or rather a cumulative process, involving waxing and waning of the ice sheet during several orbital cycles. ReferencesBartoli, G., Hönisch, B., & Zeebe, R. E. (2011). Atmospheric CO2 decline during the Pliocene intensification of Northern Hemisphere glaciations. Paleoceanography, 26(4). Contoux C, Dumas C, Ramstein G, Jost A, Dolan A. M. (2014) Modelling Greenland Ice sheet inception and sustainability during the late Pliocene. (in review for Earth and Planetary Science Letters.).Laskar, J., Robutel, P., Joutel, F., Gastineau, M., Correia, A. C. M., & Levrard, B. (2004). A long-term numerical solution for the insolation quantities of the Earth. Astronomy & Astrophysics, 428(1), 261-285. Lunt, D. J., Foster, G. L., Haywood, A. M., & Stone, E. J. (2008). Late Pliocene Greenland glaciation controlled by a decline in atmospheric CO2 levels. Nature, 454(7208), 1102-1105. Seki, O., Foster, G. L., Schmidt, D. N., Mackensen et al. (2010). Alkenone and boron-based Pliocene pCO 2 records. Earth and Planetary Science Letters, 292(1), 201-211.

Soft A 4→Z 3 symmetry breaking and cobimaximal neutrino mixing

DOE PAGES

Ma, Ernest

2016-03-28

In this study, I propose a model of radiative charged-lepton and neutrino masses with A 4 symmetry. The soft breaking of A 4 to Z 3 lepton triality is accomplished by dimension-three terms. The breaking of Z 3 by dimension-two terms allows cobimaximal neutrino mixing (θ 13 ≠ 0, θ 23 = π/4, δ cp=π/2) to be realized with only very small finite calculable deviations from the residual Z 3 lepton triality. This construction solves a long-standing technical problem inherent in renormalizable A 4 models since their inception.

A psychoanalyst views inception.

PubMed

Clemens, Norman A

2013-05-01

The author, a psychoanalyst, discusses the 2010 film, Inception, discerning the parallels and differences between cinematic dreaming states as shown in the film and psychoanalytic processes. The movie presents the unknown and un-psychoanalytic phenomena of group shared dreaming, manipulation of other people's dreams with criminal intent, and multiple structured layers of dreaming. In parallel, however, the lead character appears to work through a complicated state of derealization, mourning, guilt, rage, and loss in the course of dreaming.

Unsteady Full Annulus Simulations of a Transonic Axial Compressor Stage

NASA Technical Reports Server (NTRS)

Herrick, Gregory P.; Hathaway, Michael D.; Chen, Jen-Ping

2009-01-01

Two recent research endeavors in turbomachinery at NASA Glenn Research Center have focused on compression system stall inception and compression system aerothermodynamic performance. Physical experiment and computational research are ongoing in support of these research objectives. TURBO, an unsteady, three-dimensional, Navier-Stokes computational fluid dynamics code commissioned and developed by NASA, has been utilized, enhanced, and validated in support of these endeavors. In the research which follows, TURBO is shown to accurately capture compression system flow range-from choke to stall inception-and also to accurately calculate fundamental aerothermodynamic performance parameters. Rigorous full-annulus calculations are performed to validate TURBO s ability to simulate the unstable, unsteady, chaotic stall inception process; as part of these efforts, full-annulus calculations are also performed at a condition approaching choke to further document TURBO s capabilities to compute aerothermodynamic performance data and support a NASA code assessment effort.

Bounds of cavitation inception in a creeping flow between eccentric cylinders rotating with a small minimum gap

NASA Astrophysics Data System (ADS)

Monakhov, A. A.; Chernyavski, V. M.; Shtemler, Yu.

2013-09-01

Bounds of cavitation inception are experimentally determined in a creeping flow between eccentric cylinders, the inner one being static and the outer rotating at a constant angular velocity, Ω. The geometric configuration is additionally specified by a small minimum gap between cylinders, H, as compared with the radii of the inner and outer cylinders. For some values H and Ω, cavitation bubbles are observed, which are collected on the surface of the inner cylinder and equally distributed over the line parallel to its axis near the downstream minimum gap position. Cavitation occurs for the parameters {H,Ω} within a region bounded on the right by the cavitation inception curve that passes through the plane origin and cannot exceed the asymptotic threshold value of the minimum gap, Ha, in whose vicinity cavitation may occur at H < Ha only for high angular rotation velocities.

Thromboembolism in inflammatory bowel disease: results from a prospective, population-based European inception cohort.

PubMed

Isene, Rune; Bernklev, Tomm; Høie, Ole; Langholz, Ebbe; Tsianos, Epameonondas; Stockbrügger, Reinhold; Odes, Selwyn; Småstuen, Milada; Moum, Bjørn

2014-07-01

Patients with inflammatory bowel disease (IBD) have proven an increased risk of venous thromboembolism (VTE), particularly when hospitalized. The estimate of the true risk varies considerably between studies, primarily due to differences in methodology. We set out to determine the incidence of VTE in a population-based European inception cohort. IBD patients were incepted into a cohort that was prospectively followed from the early 1990s to the early 2000s. A total of 1145 patients were followed for a total of 10,634 patient-years (p.y.). A total of 19 thromboembolic events were identified - 13 deep vein thrombosis and 6 with pulmonary embolism. The incidence rate of VTE was 1.8 per 1000 p.y. The risk of VTE was elevated in this IBD cohort but lower than previously reported. The highest risk was seen in hospitalized patients, but corticosteroids-requiring disease in outpatients also conferred some risk.

Arc Inception Mechanism on a Solar Array Immersed in a Low-Density Plasma

NASA Technical Reports Server (NTRS)

Vayner, B.; Galofaro, J.; Ferguson, D.

2001-01-01

In this report, results are presented of an experimental and theoretical study of arc phenomena and snapover for two samples of solar arrays immersed in argon plasma. The effects of arcing and snapover are investigated. I-V curves are measured, and arc and snapover inception voltages and arc rates are determined within the wide range of plasma parameters. A considerable increase in arc rate due to absorption of molecules from atmospheric air has been confirmed. It is shown that increasing gas pressure causes increasing ion current collection and, consequently, arc rate even though the effect of conditioning also takes place. Arc sites have been determined by employing a video-camera. It is confirmed that keeping sample under high vacuum for a long time results in shifting arc threshold voltage well below -300 V. The results obtained seem to be important for the understanding of arc inception mechanism.

Analysis on the stress corrosion crack inception based on pit shape and size of the FV520B tensile specimen

NASA Astrophysics Data System (ADS)

Xiang, Longhao; Pan, Juyi; Chen, Songying

2018-06-01

The influence of pit shape and size on local stress concentration in the tensile specimen and the stress corrosion cracks inception was studied by employing the element remove technique. The maximum stress located in the bottom of pit on FV520B tensile specimen. The location of maximum strain was near the mouth of the pit or the shoulder and plastic strain existed in this region. Stress concentration factor and plastic deformation on four different geometrical shape pits of hemisphere, semi-ellipsoid, bullet and butterfly were numerically investigated, respectively. The simulation results showed that butterfly pit got the biggest stress concentration factor. The plastic strain rate during pit growth was in the sensitivity range of stress corrosion cracks inception, indicating that stress corrosion cracks were more likely to nucleate near the pit tip or the shoulder.

On Soot Inception in Nonpremixed Flames and the Effects of Flame Structure

NASA Technical Reports Server (NTRS)

Chao, B. H.; Liu, S.; Axelbaum, R. L.; Gokoglu, Suleyman (Technical Monitor)

1998-01-01

A simplified three-step model of soot inception has been employed with high activation energy asymptotics to study soot inception in nonpremixed counterflow systems with emphasis on understanding the effects of hydrodynamics and transport. The resulting scheme yields three zones: (1) a fuel oxidation zone wherein the fuel and oxidizer react to form product as well as a radical R, (e.g., H), (2) a soot/precursor formation zone where the radical R reacts with fuel to form "soot/precursor" S, and (3) a soot/precursor consumption zone where S reacts with the oxidizer to form product. The kinetic scheme, although greatly simplified, allows the coupling between soot inception and flame structure to be assessed. The results yield flame temperature, flame location, and a soot/precursor index S(sub I) as functions of Damkohler number for S formation. The soot/precursor index indicates the amount of S at the boundary of the formation region. The flame temperature indirectly indicates the total amount of S integrated over the formation region because as S is formed less heat release is available. The results show that unlike oxidation reactions, an extinction turning-point behavior does not exist for soot. Instead, the total amount of S slowly decreases with decreasing Damkohler number (increasing strain rate), which is consistent with counterflow flame experiments. When the Lewis number of the radical is decreased from unity, the total S reduces due to reduced residence time for the radical in the soot formation region. Similarly, when the Lewis number of the soot/precursor is increased from unity the amount of S increases for all Damkohler numbers. In addition to studying fuel-air (low stoichiometric mixture fraction) flames, the air-side nitrogen was substituted into the fuel, yielding diluted fuel-oxygen (high stoichiometric mixture fraction) flames with the same flame temperature as the fuel - air flames. The relative flame locations were different however, and, consistent with counterflow flame experiments, this difference was found to dramatically reduce the total amount of S generated because the change in stoichiometric mixture fraction affects residence times, temperatures and concentrations in the soot/precursor formation and consumption zones. Furthermore, while the soot/precursor consumption reaction had a negligible effect on the soot process for fuel-air flames it was very important to diluted fuel - oxygen flames.

Multi-phase functionalization of titanium for enhanced photon absorption in the vis-NIR region.

PubMed

Thakur, Pooja; Tan, Bo; Venkatakrishnan, Krishnan

2015-10-19

Inadequate absorption of Near Infrared (NIR) photons by conventional silicon solar cells has been a major stumbling block towards the attainment of a high efficiency "full spectrum" solar cell. An effective enhancement in the absorption of such photons is desired as they account for a considerable portion of the tappable solar energy. In this work, we report a remarkable gain observed in the absorption of photons in the near infrared and visible region (400 nm-1000 nm) by a novel multi-phased oxide of titanium. Synthesised via a single step ultra-fast laser pulse interaction with pure titanium, characterisation studies have identified this oxide of titanium to be multi-phased and composed of Ti3O, (TiO.716)3.76 and TiO2 (rutile). Computed to have an average band gap value of 2.39 eV, this ultrafast laser induced multi-phased titanium oxide has especially exhibited steady absorption capability in the NIR range of 750-1000 nm, which to the best of our knowledge, was never reported before. The unique NIR absorption properties of the laser functionalised titanium coupled with the simplicity and versatility of the ultrafast laser interaction process involved thereby provides tremendous potential towards the photon sensitization of titanium and thereafter for the inception of a "full spectrum" solar device.

Interventions for men and women with their first episode of genital herpes.

PubMed

Heslop, Rachel; Roberts, Helen; Flower, Deralie; Jordan, Vanessa

2016-08-30

Genital herpes is incurable, and is caused by the herpes simplex virus (HSV). First-episode genital herpes is the first clinical presentation of herpes that a person experiences. Current treatment is based around viral suppression in order to decrease the length and severity of the episode. To determine the effectiveness and safety of the different existing treatments for first-episode genital herpes on the duration of symptoms and time to recurrence. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (from inception to April 2016), MEDLINE (from inception to April 2016), the Specialised Register of the Cochrane Sexually Transmitted Infections Review Group (from inception to April 2016), EMBASE (from inception to April 2016), PsycINFO (from inception to April 2016), CINAHL (from inception to April 2016), LILACS (from inception to April 2016), AMED (from inception to April 2016), and the Alternative Medicines Specialised Register (from inception to April 2016). We handsearched a number of relevant journals, searched reference lists of all included studies, databases of ongoing trials, and other Internet databases. We included randomised controlled trials (RCTs) on participants with first-episode genital herpes. We excluded vaccination trials, and trials in which the primary objective assessed a complication of HSV infection. All studies written in English were independently assessed by at least two review authors for inclusion, risk of bias for each trial, and to extract data. Studies requiring translation were assessed for inclusion, trial quality, and data extraction by external translators. We included 26 trials with 2084 participants analysed. Most of the studies were conducted in the United Kingdom (UK) and United States (US), and involved men and women experiencing their first episode of genital herpes, with the exception of three studies which included only women. We rated the majority of these studies as having an unclear risk of bias; largely due to lack of information supplied in the publications, and due to the age of the trials. This review found low quality evidence from two studies of oral acyclovir, when compared to placebo, reduced the duration of symptoms in individuals undergoing their first episode of genital herpes (mean difference (MD) -3.22, 95% confidence interval (CI) -5.91 to -0.54; I(2) = 52%). In two studies (112 participants), intravenous acyclovir decreased the median number of days that patients with first-episode herpes suffered symptoms. Oral valaciclovir (converted to acyclovir) also showed a similar length of symptom duration when compared to acyclovir in two studies.There is currently no evidence that topical acyclovir reduces symptoms (MD -0.61 days, 95% CI -2.16 to 0.95; 3 RCTs, 195 participants, I(2) statistic = 56%). There is also no current evidence that the topical treatments of cicloxolone cream, carbenoxolone sodium cream, adenosine arabinoside, idoxuridine in dimethyl sulfoxide, when compared to placebo reduced the duration of symptoms in people undergoing their first episode of herpes.Two studies reported no evidence of a reduction in the number of median days to recurrence following treatment with oral acyclovir versus placebo. Adverse events were generally poorly reported by all of the included studies and we were unable to quantitatively analyse this outcome. For those taking acyclovir, there were no serious adverse events; the most common adverse events reported for oral acyclovir were coryza, dizziness, tiredness, diarrhoea and renal colic. For intravenous acyclovir these were phlebitis, nausea and abnormal liver function tests and for topical acyclovir there was pain with the topical application.Those undergoing interferon treatment had significantly more adverse events compared to those taking placebo. There is low quality evidence from this review that oral acyclovir reduced the duration of symptoms for genital herpes. However, there is low quality evidence which did not show that topical antivirals reduced symptom duration for patients undergoing their first episode of genital herpes. This review was limited by the inclusion of skewed data, resulting in few trials that we were able to meta-analyse.

Mars Aerial Regional-Scale Environmental Survey (ARES) Coordinate Systems Definitions and Transformations

NASA Technical Reports Server (NTRS)

Kuhl, Christoper A.

2009-01-01

The Aerial Regional-Scale Environmental Survey (ARES) is a Mars exploration mission concept with the goal of taking scientific measurements of the atmosphere, surface, and subsurface of Mars by using an airplane as the payload platform. ARES team first conducted a Phase-A study for a 2007 launch opportunity, which was completed in May 2003. Following this study, significant efforts were undertaken to reduce the risk of the atmospheric flight system, under the NASA Langley Planetary Airplane Risk Reduction Project. The concept was then proposed to the Mars Scout program in 2006 for a 2011 launch opportunity. This paper summarizes the design and development of the ARES airplane propulsion subsystem beginning with the inception of the ARES project in 2002 through the submittal of the Mars Scout proposal in July 2006.

Numerical investigation of the unsteady tip leakage flow and rotating stall inception in a transonic compressor

NASA Astrophysics Data System (ADS)

Zhang, Yanfeng; Lu, Xingen; Chu, Wuli; Zhu, Junqiang

2010-08-01

It is well known that tip leakage flow has a strong effect on the compressor performance and stability. This paper reports on a numerical investigation of detailed flow structures in an isolated transonic compressor rotor-NASA Rotor 37 at near stall and stalled conditions aimed at improving understanding of changes in 3D tip leakage flow structures with rotating stall inception. Steady and unsteady 3D Navier-Stokes analyses were conducted to investigate flow structures in the same rotor. For steady analysis, the predicted results agree well with the experimental data for the estimation of compressor rotor global performance. For unsteady flow analysis, the unsteady flow nature caused by the breakdown of the tip leakage vortex in blade tip region in the transonic compressor rotor at near stall condition has been captured with a single blade passage. On the other hand, the time-accurate unsteady computations of multi-blade passage at near stall condition indicate that the unsteady breakdown of the tip leakage vortex triggered the short length-scale — spike type rotating stall inception at blade tip region. It was the forward spillage of the tip leakage flow at blade leading edge resulting in the spike stall inception. As the mass flow ratio is decreased, the rotating stall cell was further developed in the blade passage.

Extraintestinal manifestations in Crohn's disease and ulcerative colitis: results from a prospective, population-based European inception cohort.

PubMed

Isene, Rune; Bernklev, Tomm; Høie, Ole; Munkholm, Pia; Tsianos, Epameonondas; Stockbrügger, Reinhold; Odes, Selwyn; Palm, Øyvind; Småstuen, Milada; Moum, Bjørn

2015-03-01

In chronic inflammatory bowel disease (IBD) (Crohn's disease [CD] and ulcerative colitis [UC]), symptoms from outside the gastrointestinal tract are frequently seen, and the joints, skin, eyes, and hepatobiliary area are the most usually affected sites (called extraintestinal manifestations [EIM]). The reported prevalence varies, explained by difference in study design and populations under investigation. The aim of our study was to determine the prevalence of EIM in a population-based inception cohort in Europe and Israel. IBD patients were incepted into a cohort that was prospectively followed from 1991 to 2004. A total of 1145 patients were followed for 10 years. The cumulative prevalence of first EIM was 16.9% (193/1145 patients) over a median follow-up time of 10.1 years. Patients with CD were more likely than UC patients to have immune-mediated (arthritis, eye, skin, and liver) manifestations: 20.1% versus 10.4% (p < 0.001). Most frequently seen was arthritis which was significantly more common in CD (12.9%) than in UC (8.1%), p = 0.01. Pan-colitis compared to proctitis in UC increased the risk of EIM. In a European inception cohort, EIMs in IBD were consistent with that seen in comparable studies. Patients with CD are twice as likely as UC patients to experience EIM, and more extensive distribution of inflammation in UC increases the risk of EIM.

Modeling volcano growth on the Island of Hawaii: deep-water perspectives

USGS Publications Warehouse

Lipman, Peter W.; Calvert, Andrew T.

2013-01-01

Recent ocean-bottom geophysical surveys, dredging, and dives, which complement surface data and scientific drilling at the Island of Hawaii, document that evolutionary stages during volcano growth are more diverse than previously described. Based on combining available composition, isotopic age, and geologically constrained volume data for each of the component volcanoes, this overview provides the first integrated models for overall growth of any Hawaiian island. In contrast to prior morphologic models for volcano evolution (preshield, shield, postshield), growth increasingly can be tracked by age and volume (magma supply), defining waxing alkalic, sustained tholeiitic, and waning alkalic stages. Data and estimates for individual volcanoes are used to model changing magma supply during successive compositional stages, to place limits on volcano life spans, and to interpret composite assembly of the island. Volcano volumes vary by an order of magnitude; peak magma supply also varies sizably among edifices but is challenging to quantify because of uncertainty about volcano life spans. Three alternative models are compared: (1) near-constant volcano propagation, (2) near-equal volcano durations, (3) high peak-tholeiite magma supply. These models define inconsistencies with prior geodynamic models, indicate that composite growth at Hawaii peaked ca. 800–400 ka, and demonstrate a lower current rate. Recent age determinations for Kilauea and Kohala define a volcano propagation rate of 8.6 cm/yr that yields plausible inception ages for other volcanoes of the Kea trend. In contrast, a similar propagation rate for the less-constrained Loa trend would require inception of Loihi Seamount in the future and ages that become implausibly large for the older volcanoes. An alternative rate of 10.6 cm/yr for Loa-trend volcanoes is reasonably consistent with ages and volcano spacing, but younger Loa volcanoes are offset from the Kea trend in age-distance plots. Variable magma flux at the Island of Hawaii, and longer-term growth of the Hawaiian chain as discrete islands rather than a continuous ridge, may record pulsed magma flow in the hotspot/plume source.

Diagnostic criteria for hepatocellular carcinoma ⩽3 cm with hepatocyte-specific contrast-enhanced magnetic resonance imaging.

PubMed

Choi, Sang Hyun; Byun, Jae Ho; Lim, Young-Suk; Yu, Eunsil; Lee, So Jung; Kim, So Yeon; Won, Hyung Jin; Shin, Yong Moon; Kim, Pyo Nyun

2016-05-01

Current diagnostic imaging criteria for hepatocellular carcinoma (HCC) are dedicated to imaging with nonspecific extracellular contrast agents. This study aimed to evaluate diagnostic criteria for HCC ⩽3 cm on magnetic resonance imaging (MRI) with a hepatocyte-specific contrast agent through an inception cohort study. Of 291 patients with chronic liver disease and new nodules of 1-3 cm in diameter at surveillance ultrasonography, 295 solid nodules (194 HCCs, 98 benign nodules, and three other malignancies) in 198 patients with a confirmed final diagnosis or ⩾24 months follow-up were evaluated on gadoxetic acid-enhanced MRI. Through univariate and multivariate logistic regression analyses, various diagnostic criteria were developed by combining significant MRI findings for diagnosing HCC. The diagnostic performance of each criterion was compared with that of the European Association for the Study of the Liver (EASL) criteria. Four MRI findings (arterial-phase hyperintensity, transitional-phase hypointensity, hepatobiliary-phase hypointensity, and rim enhancement) were independently significant for diagnosis of HCC ⩽3 cm. For whole nodules, EASL criteria showed the best performance for diagnosing HCC (sensitivity, 83.5%; specificity, 81.2%). For nodules ⩽2 cm in diameter, a new criterion (arterial-phase hyperintensity and hepatobiliary-phase hypointensity) showed a significantly higher sensitivity than that of the EASL criteria (83.0% vs. 74.5%, p=0.008), without a significantly different specificity (76.7% vs. 81.1%, p=0.125). EASL criteria exhibit the best diagnostic performance for HCC ⩽3 cm on hepatocyte-specific contrast-enhanced MRI. A newly identified criterion (arterial-phase hyperintensity and hepatobiliary-phase hypointensity) may increase the diagnostic sensitivity of small (⩽2 cm) HCC. Copyright © 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Effects of the menstrual cycle on lower-limb biomechanics, neuromuscular control, and anterior cruciate ligament injury risk: a systematic review.

PubMed

Balachandar, Vivek; Marciniak, Jan-Luigi; Wall, Owen; Balachandar, Chandrika

2017-01-01

Anterior cruciate ligament (ACL) injury has a devastating impact on physical and psychological disability. Rates of ACL rupture are significantly greater in females than males during the same sports. Hormonal mechanisms have been proposed but are complex and poorly understood. This systematic review evaluates the effects of menstrual cycle on: 1) lower-limb biomechanics, 2) neuromuscular control, and 3) ACL injury risk. The MEDLINE, CINAHL, SPORTSDiscus, Web of Science, and Google Scholar databases were searched from inception to August 2016 for studies investigating the effects of the menstrual cycle on lower-limb biomechanics, neuromuscular control, and ACL injury risk in females. Three independent reviewers assessed each paper for inclusion and two assessed for quality. Seventeen studies were identified. There is strong evidence that: 1) greatest risk of ACL injury is within the pre-ovulatory phase of the menstrual cycle, and 2) females with greater ACL laxity in the pre-ovulatory phase experience greater knee valgus and greater tibial external rotation during functional activity. Females are at greatest risk of ACL injury during the pre-ovulatory phase of the menstrual cycle through a combination of greater ACL laxity, greater knee valgus, and greater tibial external rotation during functional activity. Ib.

Oral health of children with type 1 diabetes mellitus: A systematic review.

PubMed

Ismail, Ahmad Faisal; McGrath, Colman Patrick; Yiu, Cynthia K Y

2015-06-01

This systematic review investigated the oral health status of children with type 1 diabetes. A systematic search was conducted using PubMed/Medline, Web of Knowledge, SCOPUS and EMBASE. The search included all studies published from inception of database to January 2014. A total of 1179 abstracts were analyzed for selection in 2 phases. The first phase selection was based on the title and abstracts alone. The selected abstracts were then included for second phase, where full articles were obtained. The selection was carried out by 2 independent reviewers (Kappa value=0.809). Only 37 articles were included for final analysis in this review. There is conflicting evidence in the caries experience between children with type 1 diabetes and healthy children. For periodontal health, most studies reported significantly greater plaque accumulation and higher gingival index in children with type 1 diabetes. Cohort studies reported no significant differences in perioodontal parameters over time. There is conflicting evidence regarding the caries experience of children with type 1 diabetes, but they exhibit poorer periodontal health status with greater plaque accumulation compared to healthy children. Further studies are warranted to assess the oral health status of children with type 1 diabetes. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

The PMIP4 Contribution to CMIP6-Part 4: Scientific Objectives and Experimental Design of the PMIP4-CMIP6 Last Glacial Maximum Experiments and PMIP4 Sensitivity Experiments

NASA Technical Reports Server (NTRS)

Kageyama, Masa; Albani, Samuel; Braconnot, Pascale; Harrison, Sandy P.; Hopcroft, Peter O.; Ivanovic, Ruza F.; Lambert, Fabrice; Marti, Olivier; Peltier, W. Richard; Peterschmitt, Jean-Yves;

The PMIP4 contribution to CMIP6 - Part 4: Scientific objectives and experimental design of the PMIP4-CMIP6 Last Glacial Maximum experiments and PMIP4 sensitivity experiments

NASA Astrophysics Data System (ADS)

Kageyama, Masa; Albani, Samuel; Braconnot, Pascale; Harrison, Sandy P.; Hopcroft, Peter O.; Ivanovic, Ruza F.; Lambert, Fabrice; Marti, Olivier; Peltier, W. Richard; Peterschmitt, Jean-Yves; Roche, Didier M.; Tarasov, Lev; Zhang, Xu; Brady, Esther C.; Haywood, Alan M.; LeGrande, Allegra N.; Lunt, Daniel J.; Mahowald, Natalie M.; Mikolajewicz, Uwe; Nisancioglu, Kerim H.; Otto-Bliesner, Bette L.; Renssen, Hans; Tomas, Robert A.; Zhang, Qiong; Abe-Ouchi, Ayako; Bartlein, Patrick J.; Cao, Jian; Li, Qiang; Lohmann, Gerrit; Ohgaito, Rumi; Shi, Xiaoxu; Volodin, Evgeny; Yoshida, Kohei; Zhang, Xiao; Zheng, Weipeng

2017-11-01

The Last Glacial Maximum (LGM, 21 000 years ago) is one of the suite of paleoclimate simulations included in the current phase of the Coupled Model Intercomparison Project (CMIP6). It is an interval when insolation was similar to the present, but global ice volume was at a maximum, eustatic sea level was at or close to a minimum, greenhouse gas concentrations were lower, atmospheric aerosol loadings were higher than today, and vegetation and land-surface characteristics were different from today. The LGM has been a focus for the Paleoclimate Modelling Intercomparison Project (PMIP) since its inception, and thus many of the problems that might be associated with simulating such a radically different climate are well documented. The LGM state provides an ideal case study for evaluating climate model performance because the changes in forcing and temperature between the LGM and pre-industrial are of the same order of magnitude as those projected for the end of the 21st century. Thus, the CMIP6 LGM experiment could provide additional information that can be used to constrain estimates of climate sensitivity. The design of the Tier 1 LGM experiment (lgm) includes an assessment of uncertainties in boundary conditions, in particular through the use of different reconstructions of the ice sheets and of the change in dust forcing. Additional (Tier 2) sensitivity experiments have been designed to quantify feedbacks associated with land-surface changes and aerosol loadings, and to isolate the role of individual forcings. Model analysis and evaluation will capitalize on the relative abundance of paleoenvironmental observations and quantitative climate reconstructions already available for the LGM.

Cavitation Inception Scale Effects. 1. Nuclei Distributions in Natural Waters. 2. Cavitation Inception in a Turbulent Shear Flow.

DTIC Science & Technology

1987-05-01

ratio of specific heats for the gas and an adiabatic bubble pressure- volume relation has been assumed (Plesset & Prosperetti 1977). When viscosity...pressure because of surface tension at the gas -liquid interface , so the gas is stabilized in the crevice and will not dissolve into the liquid. The concave... interface toward the gas is estab- lished by the hydrophobic nature of the particle, and results in surface tension acting to oppose the liquid

Leveraged Leasing in the Federal Sector.

DTIC Science & Technology

1983-12-01

adjustments, is 90% or more of the fair value of the leased property. [Ref. 81 Capital type leases are classified as direct financing or sales type leases on...sales-type a profit or loss would occur [Ref. 7]. In a sales-type lease the fair value of the leased property at the inception of the lease differs...from the cost or carrying amount; in a direct financing lease, the fair value of the leased 28 property at the inception of the lease is the cost or

Predictive Models to Estimate Probabilities of Injuries and Adverse Performance Outcomes in U.S. Army Basic Combat Training

DTIC Science & Technology

2014-03-01

orofacial injuries.10 These and other efforts have been associated with reduced BCT injuries over time as shown in Figure 111 but injury incidence...to predict first episode of low back pain in Soldiers undergoing combat medic training. Moran et al30 reported an AUG of . 765 for a pragmatic 5...Dugan JL, Robinson ME. Predictors of occurrence and severity of first time low back pain episodes: Findings from a military inception cohort. PLoS

Development of Predictive Models of Advanced Propulsion Concepts for Low Cost Space Transportation

NASA Technical Reports Server (NTRS)

Morrell, Michael Randy

2002-01-01

This final report presents the Graduate Student Research Program (GSRP) work Mr. Morrell was able to complete as a summer intern at NASA MSFS during the summer of 2001, and represents work completed from inception through project termination. The topics include: 1) NASA TD40 Organization; 2) Combustion Physics Lab; 3) Advanced Hydrocarbon Fuels; 4) GSRP Summer Tasks; 5) High Pressure Facility Installation; 6) High Pressure Combustion Issues; 7) High Energy Density Matter (HEDM) Hydrocarbons; and 8) GSRP Summer Intern Summary.

Hydroelastic behaviour of a structure exposed to an underwater explosion.

PubMed

Colicchio, G; Greco, M; Brocchini, M; Faltinsen, O M

2015-01-28

The hydroelastic interaction between an underwater explosion and an elastic plate is investigated num- erically through a domain-decomposition strategy. The three-dimensional features of the problem require a large computational effort, which is reduced through a weak coupling between a one-dimensional radial blast solver, which resolves the blast evolution far from the boundaries, and a three-dimensional compressible flow solver used where the interactions between the compression wave and the boundaries take place and the flow becomes three-dimensional. The three-dimensional flow solver at the boundaries is directly coupled with a modal structural solver that models the response of the solid boundaries like elastic plates. This enables one to simulate the fluid-structure interaction as a strong coupling, in order to capture hydroelastic effects. The method has been applied to the experimental case of Hung et al. (2005 Int. J. Impact Eng. 31, 151-168 (doi:10.1016/j.ijimpeng.2003.10.039)) with explosion and structure sufficiently far from other boundaries and successfully validated in terms of the evolution of the acceleration induced on the plate. It was also used to investigate the interaction of an underwater explosion with the bottom of a close-by ship modelled as an orthotropic plate. In the application, the acoustic phase of the fluid-structure interaction is examined, highlighting the need of the fluid-structure coupling to capture correctly the possible inception of cavitation. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

A quantitative study of the clustering of polycyclic aromatic hydrocarbons at high temperatures.

PubMed

Totton, Tim S; Misquitta, Alston J; Kraft, Markus

2012-03-28

The clustering of polycyclic aromatic hydrocarbon (PAH) molecules is investigated in the context of soot particle inception and growth using an isotropic potential developed from the benchmark PAHAP potential. This potential is used to estimate equilibrium constants of dimerisation for five representative PAH molecules based on a statistical mechanics model. Molecular dynamics simulations are also performed to study the clustering of homomolecular systems at a range of temperatures. The results from both sets of calculations demonstrate that at flame temperatures pyrene (C(16)H(10)) dimerisation cannot be a key step in soot particle formation and that much larger molecules (e.g. circumcoronene, C(54)H(18)) are required to form small clusters at flame temperatures. The importance of using accurate descriptions of the intermolecular interactions is demonstrated by comparing results to those calculated with a popular literature potential with an order of magnitude variation in the level of clustering observed. By using an accurate intermolecular potential we are able to show that physical binding of PAH molecules based on van der Waals interactions alone can only be a viable soot inception mechanism if concentrations of large PAH molecules are significantly higher than currently thought.

Revisiting the positive DC corona discharge theory: Beyond Peek's and Townsend's law

NASA Astrophysics Data System (ADS)

Monrolin, Nicolas; Praud, Olivier; Plouraboué, Franck

2018-06-01

The classical positive Corona Discharge theory in a cylindrical axisymmetric configuration is revisited in order to find analytically the influence of gas properties and thermodynamic conditions on the corona current. The matched asymptotic expansion of Durbin and Turyn [J. Phys. D: Appl. Phys. 20, 1490-1495 (1987)] of a simplified but self-consistent problem is performed and explicit analytical solutions are derived. The mathematical derivation enables us to express a new positive DC corona current-voltage characteristic, choosing either a dimensionless or dimensional formulation. In dimensional variables, the current voltage law and the corona inception voltage explicitly depend on the electrode size and physical gas properties such as ionization and photoionization parameters. The analytical predictions are successfully confronted with experiments and Peek's and Townsend's laws. An analytical expression of the corona inception voltage φ o n is proposed, which depends on the known values of physical parameters without adjustable parameters. As a proof of consistency, the classical Townsend current-voltage law I = C φ ( φ - φ o n ) is retrieved by linearizing the non-dimensional analytical solution. A brief parametric study showcases the interest in this analytical current model, especially for exploring small corona wires or considering various thermodynamic conditions.

Modelling large-scale ice-sheet-climate interactions at the last glacial inception

NASA Astrophysics Data System (ADS)

Browne, O. J. H.; Gregory, J. M.; Payne, A. J.; Ridley, J. K.; Rutt, I. C.

2010-05-01

In order to investigate the interactions between coevolving climate and ice-sheets on multimillenial timescales, a low-resolution atmosphere-ocean general circulation model (AOGCM) has been coupled to a three-dimensional thermomechanical ice-sheet model. We use the FAMOUS AOGCM, which is almost identical in formulation to the widely used HadCM3 AOGCM, but on account of its lower resolution (7.5° longitude × 5° latitude in the atmosphere, 3.75°× 2.5° in the ocean) it runs about ten times faster. We use the community ice-sheet model Glimmer at 20 km resolution, with the shallow ice approximation and an annual degree-day scheme for surface mass balance. With the FAMOUS-Glimmer coupled model, we have simulated the growth of the Laurentide and Fennoscandian ice sheets at the last glacial inception, under constant orbital forcing and atmospheric composition for 116 ka BP. Ice grows in both regions, totalling 5.8 m of sea-level equivalent in 10 ka, slower than proxy records suggest. Positive climate feedbacks reinforce this growth at local scales (order hundreds of kilometres), where changes are an order of magnitude larger than on the global average. The albedo feedback (higher local albedo means a cooler climate) is important in the initial expansion of the ice-sheet area. The topography feedback (higher surface means a cooler climate) affects ice-sheet thickness and is not noticeable for the first 1 ka. These two feedbacks reinforce each other. Without them, the ice volume is ~90% less after 10 ka. In Laurentia, ice expands initially on the Canadian Arctic islands. The glaciation of the islands eventually cools the nearby mainland climate sufficiently to produce a positive mass balance there. Adjacent to the ice-sheets, cloud feedbacks tend to reduce the surface mass balance and restrain ice growth; this is an example of a local feedback whose simulation requires a model that includes detailed atmospheric physics.

Positionalism of Relations and Its Consequences for Fact-Oriented Modelling

NASA Astrophysics Data System (ADS)

Keet, C. Maria

Natural language-based conceptual modelling as well as the use of diagrams have been essential components of fact-oriented modelling from its inception. However, transforming natural language to its corresponding object-role modelling diagram, and vv., is not trivial. This is due to the more fundamental problem of the different underlying ontological commitments concerning positionalism of the fact types. The natural language-based approach adheres to the standard view whereas the diagram-based approach has a positionalist commitment, which is, from an ontological perspective, incompatible with the former. This hinders seamless transition between the two approaches and affects interoperability with other conceptual modelling languages. One can adopt either the limited standard view or the positionalist commitment with fact types that may not be easily verbalisable but which facilitates data integration and reusability of conceptual models with ontological foundations.

Cavitation bubble nucleation induced by shock-bubble interaction in a gelatin gel

NASA Astrophysics Data System (ADS)

Oguri, Ryota; Ando, Keita

2018-05-01

An optical visualization technique is developed to study cavitation bubble nucleation that results from interaction between a laser-induced shock and a preexisting gas bubble in a 10 wt. % gelatin gel; images of the nucleated cavitation bubbles are captured and the cavitation inception pressure is determined based on Euler flow simulation. A spherical gas cavity is generated by focusing an infrared laser pulse into a gas-supersaturated gel and the size of the laser-generated bubble in mechanical equilibrium is tuned via mass transfer of the dissolved gas into the bubble. A spherical shock is then generated, through rapid expansion of plasma induced by the laser focusing, in the vicinity of the gas bubble. The shock-bubble interaction is recorded by a CCD camera with flash illumination of a nanosecond green laser pulse. The observation captures cavitation inception in the gel under tension that results from acoustic impedance mismatching at the bubble interface interacting with the shock. We measure the probability of cavitation inception from a series of the repeated experiments, by varying the bubble radius and the standoff distance. The threshold pressure is defined at the cavitation inception probability equal to one half and is calculated, through comparisons to Euler flow simulation, at -24.4 MPa. This threshold value is similar to that from shock-bubble interaction experiments using water, meaning that viscoelasticity of the 10 wt. % gelatin gel has a limited impact on bubble nucleation dynamics.

Fundamental Study on Self-healing Insulation Performance of Silicone Rubber Affected by Local Breakdown

NASA Astrophysics Data System (ADS)

Hozumi, Naohiro; Nishioka, Koji; Suematsu, Takeshi; Murakami, Yoshinobu; Nagao, Masayuki; Sakata, Hiroshi

Feasibility of self-healing insulation system was studied. A silicone rubber without filler was mounted on a glass substrate with a needle electrode. An ac voltage with 4 kV in rms was applied. The voltage was cut off when the tree had propagated into 150 micrometers in length. After the cut-off, the partial discharge inception voltage was periodically observed. The partial discharge inception voltage had once reduced into as low as 2 kV. However, it gradually increased with time, and finally exceeded the tree inception voltage (4 kV) when 30 - 60 hours had passed. It was also observed by optical microscope that the tree gradually disappeared in parallel with the recovery of the partial discharge inception voltage. The same phenomenon was observed even if 1 kV ac voltage had been continuously applied during the process of the recovery. A simulation using a needle-shaped void was performed in order to clarify the mechanism of the self-healing effect. It was observed that the tip of the needle-shaped void gradually got wet with a liquid material. It would be the result of "bleed-out" of the low molecular component included in the rubber. The tip of the void was finally filled with the liquid, however, the rest of the needle-shaped void stayed without being filled. In this type of tree, it was suggested that the self-healing effect is expected if the diameter of the tree did not exceed ca. 5 micrometers.

Investigation of Turbulent Tip Leakage Vortex in an Axial Water Jet Pump with Large Eddy Simulation

NASA Technical Reports Server (NTRS)

Hah, Chunill; Katz, Joseph

2012-01-01

Detailed steady and unsteady numerical studies were performed to investigate tip clearance flow in an axial water jet pump. The primary objective is to understand physics of unsteady tip clearance flow, unsteady tip leakage vortex, and cavitation inception in an axial water jet pump. Steady pressure field and resulting steady tip leakage vortex from a steady flow analysis do not seem to explain measured cavitation inception correctly. The measured flow field near the tip is unsteady and measured cavitation inception is highly transient. Flow visualization with cavitation bubbles shows that the leakage vortex is oscillating significantly and many intermittent vortex ropes are present between the suction side of the blade and the tip leakage core vortex. Although the flow field is highly transient, the overall flow structure is stable and a characteristic frequency seems to exist. To capture relevant flow physics as much as possible, a Reynolds-averaged Navier-Stokes (RANS) calculation and a Large Eddy Simulation (LES) were applied for the current investigation. The present study reveals that several vortices from the tip leakage vortex system cross the tip gap of the adjacent blade periodically. Sudden changes in local pressure field inside tip gap due to these vortices create vortex ropes. The instantaneous pressure filed inside the tip gap is drastically different from that of the steady flow simulation. Unsteady flow simulation which can calculate unsteady vortex motion is necessary to calculate cavitation inception accurately even at design flow condition in such a water jet pump.

Computational fluid dynamic modelling of cavitation

NASA Technical Reports Server (NTRS)

Deshpande, Manish; Feng, Jinzhang; Merkle, Charles L.

1993-01-01

Models in sheet cavitation in cryogenic fluids are developed for use in Euler and Navier-Stokes codes. The models are based upon earlier potential-flow models but enable the cavity inception point, length, and shape to be determined as part of the computation. In the present paper, numerical solutions are compared with experimental measurements for both pressure distribution and cavity length. Comparisons between models are also presented. The CFD model provides a relatively simple modification to an existing code to enable cavitation performance predictions to be included. The analysis also has the added ability of incorporating thermodynamic effects of cryogenic fluids into the analysis. Extensions of the current two-dimensional steady state analysis to three-dimensions and/or time-dependent flows are, in principle, straightforward although geometrical issues become more complicated. Linearized models, however offer promise of providing effective cavitation modeling in three-dimensions. This analysis presents good potential for improved understanding of many phenomena associated with cavity flows.

International Geomagnetic Reference Field: the third generation.

USGS Publications Warehouse

Peddie, N.W.

1982-01-01

In August 1981 the International Association of Geomagnetism and Aeronomy revised the International Geomagnetic Reference Field (IGRF). It is the second revision since the inception of the IGRF in 1968. The revision extends the earlier series of IGRF models from 1980 to 1985, introduces a new series of definitive models for 1965-1976, and defines a provisional reference field for 1975- 1980. The revision consists of: 1) a model of the main geomagnetic field at 1980.0, not continuous with the earlier series of IGRF models together with a forecast model of the secular variation of the main field during 1980-1985; 2) definitive models of the main field at 1965.0, 1970.0, and 1975.0, with linear interpolation of the model coefficients specified for intervening dates; and 3) a provisional reference field for 1975-1980, defined as the linear interpolation of the 1975 and 1980 main-field models.-from Author

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rutqvist, Jonny; Cappa, Frédéric; Rinaldi, Antonio P.

In this paper, we present model simulations of ground motions caused by CO 2 -injection-induced fault reactivation and analyze the results in terms of the potential for damage to ground surface structures and nuisance to the local human population. It is an integrated analysis from cause to consequence, including the whole chain of processes starting from earthquake inception in the subsurface, wave propagation toward the ground surface, and assessment of the consequences of ground vibration. For a small magnitude (M w =3) event at a hypocenter depth of about 1000m, we first used the simulated ground-motion wave train in anmore » inverse analysis to estimate source parameters (moment magnitude, rupture dimensions and stress drop), achieving good agreement and thereby verifying the modeling of the chain of processes from earthquake inception to ground vibration. We then analyzed the ground vibration results in terms of peak ground acceleration (PGA), peak ground velocity (PGV) and frequency content, with comparison to U.S. Geological Survey's instrumental intensity scales for earthquakes and the U.S. Bureau of Mines' vibration criteria for cosmetic damage to buildings, as well as human-perception vibration limits. Our results confirm the appropriateness of using PGV (rather than PGA) and frequency for the evaluation of potential ground-vibration effects on structures and humans from shallow injection-induced seismic events. For the considered synthetic M w =3 event, our analysis showed that the short duration, high frequency ground motion may not cause any significant damage to surface structures, but would certainly be felt by the local population.« less

Dynamically rich, yet parameter-sparse models for spatial epidemiology. Comment on "Coupled disease-behavior dynamics on complex networks: A review" by Z. Wang et al.

NASA Astrophysics Data System (ADS)

Jusup, Marko; Iwami, Shingo; Podobnik, Boris; Stanley, H. Eugene

2015-12-01

Since the very inception of mathematical modeling in epidemiology, scientists exploited the simplicity ingrained in the assumption of a well-mixed population. For example, perhaps the earliest susceptible-infectious-recovered (SIR) model developed by L. Reed and W.H. Frost in the 1920s [1], included the well-mixed assumption such that any two individuals in the population could meet each other. The problem was that, unlike many other simplifying assumptions used in epidemiological modeling whose validity holds in one situation or the other, well-mixed populations are almost non-existent in reality because the nature of human socio-economic interactions is, for the most part, highly heterogeneous (e.g. [2-6]).

Korean letter handwritten recognition using deep convolutional neural network on android platform

NASA Astrophysics Data System (ADS)

Purnamawati, S.; Rachmawati, D.; Lumanauw, G.; Rahmat, R. F.; Taqyuddin, R.

2018-03-01

Currently, popularity of Korean culture attracts many people to learn everything about Korea, particularly its language. To acquire Korean Language, every single learner needs to be able to understand Korean non-Latin character. A digital approach needs to be carried out in order to make Korean learning process easier. This study is done by using Deep Convolutional Neural Network (DCNN). DCNN performs the recognition process on the image based on the model that has been trained such as Inception-v3 Model. Subsequently, re-training process using transfer learning technique with the trained and re-trained value of model is carried though in order to develop a new model with a better performance without any specific systemic errors. The testing accuracy of this research results in 86,9%.

Design of a Mars Airplane Propulsion System for the Aerial Regional-Scale Environmental Survey (ARES) Mission Concept

NASA Technical Reports Server (NTRS)

Kuhl. Christopher A.

2009-01-01

The Aerial Regional-Scale Environmental Survey (ARES) is a Mars exploration mission concept with the goal of taking scientific measurements of the atmosphere, surface, and subsurface of Mars by using an airplane as the payload platform. ARES team first conducted a Phase-A study for a 2007 launch opportunity, which was completed in May 2003. Following this study, significant efforts were undertaken to reduce the risk of the atmospheric flight system, under the NASA Langley Planetary Airplane Risk Reduction Project. The concept was then proposed to the Mars Scout program in 2006 for a 2011 launch opportunity. This paper summarizes the design and development of the ARES airplane propulsion subsystem beginning with the inception of the ARES project in 2002 through the submittal of the Mars Scout proposal in July 2006.

CAR therapy: the CD19 paradigm

PubMed Central

Sadelain, Michel

2015-01-01

Twenty-five years after its inception, the genetic engineering of T cells is now a therapeutic modality pursued at an increasing number of medical centers. This immunotherapeutic strategy is predicated on gene transfer technology to instruct T lymphocytes to recognize and reject tumor cells. Chimeric antigen receptors (CARs) are synthetic receptors that mediate antigen recognition, T cell activation, and — in the case of second-generation CARs — costimulation to augment T cell functionality and persistence. We demonstrated over a decade ago that human T cells engineered with a CD19-specific CAR eradicated B cell malignancies in mice. Several phase I clinical trials eventually yielded dramatic results in patients with leukemia or lymphoma, especially acute lymphoblastic leukemia (ALL). This review recounts the milestones of CD19 CAR therapy and summarizes lessons learned from the CD19 paradigm. PMID:26325036

A physics department's role in preparing physics teachers: The Colorado learning assistant model

NASA Astrophysics Data System (ADS)

Otero, Valerie; Pollock, Steven; Finkelstein, Noah

2010-11-01

In response to substantial evidence that many U.S. students are inadequately prepared in science and mathematics, we have developed an effective and adaptable model that improves the education of all students in introductory physics and increases the numbers of talented physics majors becoming certified to teach physics. We report on the Colorado Learning Assistant model and discuss its effectiveness at a large research university. Since its inception in 2003, we have increased the pool of well-qualified K-12 physics teachers by a factor of approximately three, engaged scientists significantly in the recruiting and preparation of future teachers, and improved the introductory physics sequence so that students' learning gains are typically double the traditional average.

Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort.

PubMed

Urowitz, M B; Gladman, D D; Ibañez, D; Fortin, P R; Bae, S C; Gordon, C; Clarke, A; Bernatsky, S; Hanly, J G; Isenberg, D; Rahman, A; Sanchez-Guerrero, J; Wallace, D J; Ginzler, E; Alarcón, G S; Merrill, J T; Bruce, I N; Sturfelt, G; Nived, O; Steinsson, K; Khamashta, M; Petri, M; Manzi, S; Ramsey-Goldman, R; Dooley, M A; van Vollenhoven, R F; Ramos, M; Stoll, T; Zoma, A; Kalunian, K; Aranow, C

2012-01-01

We describe disease activity, damage, and the accrual of key autoantibodies in an inception systemic lupus erythematosus (SLE) cohort. The Systemic Lupus International Collaborating Clinics (SLICC) International Research Network, comprising 27 centers from 11 countries, has followed an inception cohort of SLE patients yearly according to a standardized protocol. Of these patients, 298 were followed for a minimum of 5 years and constitute the study population. Disease activity was assessed using the SLE Disease Activity Index 2000 (SLEDAI-2K) and damage was assessed using the SLICC/American College of Rheumatology Damage Index (SDI). Antinuclear antibody (ANA), anti-DNA, and anticardiolipin antibody (aCL) levels and lupus anticoagulant were assessed yearly. Descriptive statistics were generated and repeated-measures general linear models were used to evaluate SLEDAI-2K and SDI over time between whites and nonwhites. Of the 298 patients, 87% were women, 55% were white, 12% were African American, 14% were Asian, 16% were Hispanic, and 2% were categorized as "other." At enrollment, the mean age was 35.3 years, the mean SLEDAI-2K score was 5.9, and the mean disease duration was 5.5 months. Mean SLEDAI-2K scores decreased in the first year and then remained low. SLEDAI-2K scores were significantly lower at each year in whites compared to nonwhites. Mean SDI scores increased progressively over 5 years; there was no significant difference between whites and nonwhites. As expected, ANA positivity was high and anti-DNA positivity was relatively low at enrollment, and both increased over 5 years. Although lupus anticoagulant increased slightly over 5 years, aCL positivity did not. Disease activity in newly diagnosed patients decreases over their first 5 years, while damage increases. Antibody positivity ran variable courses over this period. Copyright © 2012 by the American College of Rheumatology.

Holocene glacier and climate variations in Vestfirðir, Iceland, from the modeling of Drangajökull ice cap

NASA Astrophysics Data System (ADS)

Anderson, Leif S.; Flowers, Gwenn E.; Jarosch, Alexander H.; Aðalgeirsdóttir, Guðfinna Th; Geirsdóttir, Áslaug; Miller, Gifford H.; Harning, David J.; Thorsteinsson, Thorsteinn; Magnússon, Eyjólfur; Pálsson, Finnur

2018-06-01

Drangajökull is a maritime ice cap located in northwest (Vestfirðir) Iceland. Drangajökull's evolution is therefore closely linked to atmospheric and ocean variability. In order to better constrain the Holocene climate and glacier history of Vestfirðir we model the past evolution of Drangajökull ice cap. Simulations from 10 ka to present are forced by general circulation model output, ice-core-based temperature reconstructions, and sea-surface temperature reconstructions. Based on these 10-thousand year simulations, Drangajökull did not persist through the Holocene. We estimate that air temperatures were 2.5-3.0 °C higher during the Holocene Thermal Maximum than the local 1960-1990 average. Simulations support Drangajökull's late Holocene inception between 2 and 1 ka, though intermittent ice likely occupied cirques as early as 2.6 ka. Drangajökull is primarily a Little Ice Age ice cap: it expanded between 1300 and 1750 CE, with the most rapid growth occurring between 1600 and 1750 CE. The maximum Holocene extent of Drangajökull occurred between 1700 and 1925 CE, despite the lowest late Holocene temperatures, occurring between 1650 and 1720 CE. Between 1700 and 1925 CE temperatures were likely 0.6-0.8 °C lower than the 1950-2015 reference temperature. The modern equilibrium line altitude (ELA) is bracketed by topographic thresholds: a 1 °C temperature increase from the modern ELA would eliminate the ice cap's accumulation area, while a reduction of 0.5 °C would lead to the rapid expansion of the ice cap across Vestfirðir. The proximity of Drangajökull to topographic thresholds may explain its late inception and rapid expansion during the Little Ice Age.

Modeling of induced seismicity and ground vibrations associated with geologic CO 2 storage, and assessing their effects on surface structures and human perception

DOE PAGES

Rutqvist, Jonny; Cappa, Frédéric; Rinaldi, Antonio P.; ...

2014-05-01

In this paper, we present model simulations of ground motions caused by CO 2 -injection-induced fault reactivation and analyze the results in terms of the potential for damage to ground surface structures and nuisance to the local human population. It is an integrated analysis from cause to consequence, including the whole chain of processes starting from earthquake inception in the subsurface, wave propagation toward the ground surface, and assessment of the consequences of ground vibration. For a small magnitude (M w =3) event at a hypocenter depth of about 1000m, we first used the simulated ground-motion wave train in anmore » inverse analysis to estimate source parameters (moment magnitude, rupture dimensions and stress drop), achieving good agreement and thereby verifying the modeling of the chain of processes from earthquake inception to ground vibration. We then analyzed the ground vibration results in terms of peak ground acceleration (PGA), peak ground velocity (PGV) and frequency content, with comparison to U.S. Geological Survey's instrumental intensity scales for earthquakes and the U.S. Bureau of Mines' vibration criteria for cosmetic damage to buildings, as well as human-perception vibration limits. Our results confirm the appropriateness of using PGV (rather than PGA) and frequency for the evaluation of potential ground-vibration effects on structures and humans from shallow injection-induced seismic events. For the considered synthetic M w =3 event, our analysis showed that the short duration, high frequency ground motion may not cause any significant damage to surface structures, but would certainly be felt by the local population.« less

A reconstruction of atmospheric carbon dioxide and its stable carbon isotopic composition from the penultimate glacial maximum to the last glacial inception

NASA Astrophysics Data System (ADS)

Schneider, R.; Schmitt, J.; Köhler, P.; Joos, F.; Fischer, H.

2013-11-01

The reconstruction of the stable carbon isotope evolution in atmospheric CO2 (δ13Catm), as archived in Antarctic ice cores, bears the potential to disentangle the contributions of the different carbon cycle fluxes causing past CO2 variations. Here we present a new record of δ13Catm before, during and after the Marine Isotope Stage 5.5 (155 000 to 105 000 yr BP). The dataset is archived on the data repository PANGEA® (www.pangea.de) under 10.1594/PANGAEA.817041. The record was derived with a well established sublimation method using ice from the EPICA Dome C (EDC) and the Talos Dome ice cores in East Antarctica. We find a 0.4‰ shift to heavier values between the mean δ13Catm level in the Penultimate (~ 140 000 yr BP) and Last Glacial Maximum (~ 22 000 yr BP), which can be explained by either (i) changes in the isotopic composition or (ii) intensity of the carbon input fluxes to the combined ocean/atmosphere carbon reservoir or (iii) by long-term peat buildup. Our isotopic data suggest that the carbon cycle evolution along Termination II and the subsequent interglacial was controlled by essentially the same processes as during the last 24 000 yr, but with different phasing and magnitudes. Furthermore, a 5000 yr lag in the CO2 decline relative to EDC temperatures is confirmed during the glacial inception at the end of MIS5.5 (120 000 yr BP). Based on our isotopic data this lag can be explained by terrestrial carbon release and carbonate compensation.

The international workshop on wave hindcasting and forecasting and the coastal hazards symposium

NASA Astrophysics Data System (ADS)

Breivik, Øyvind; Swail, Val; Babanin, Alexander V.; Horsburgh, Kevin

2015-05-01

Following the 13th International Workshop on Wave Hindcasting and Forecasting and 4th Coastal Hazards Symposium in October 2013 in Banff, Canada, a topical collection has appeared in recent issues of Ocean Dynamics. Here, we give a brief overview of the history of the conference since its inception in 1986 and of the progress made in the fields of wind-generated ocean waves and the modelling of coastal hazards before we summarize the main results of the papers that have appeared in the topical collection.

Philippine Sea Plate inception, evolution, and consumption with special emphasis on the early stages of Izu-Bonin-Mariana subduction

NASA Astrophysics Data System (ADS)

Lallemand, Serge

2016-12-01

We compiled the most relevant data acquired throughout the Philippine Sea Plate (PSP) from the early expeditions to the most recent. We also analyzed the various explanatory models in light of this updated dataset. The following main conclusions are discussed in this study. (1) The Izanagi slab detachment beneath the East Asia margin around 60-55 Ma likely triggered the Oki-Daito plume occurrence, Mesozoic proto-PSP splitting, shortening and then failure across the paleo-transform boundary between the proto-PSP and the Pacific Plate, Izu-Bonin-Mariana subduction initiation and ultimately PSP inception. (2) The initial splitting phase of the composite proto-PSP under the plume influence at ˜54-48 Ma led to the formation of the long-lived West Philippine Basin and short-lived oceanic basins, part of whose crust has been ambiguously called "fore-arc basalts" (FABs). (3) Shortening across the paleo-transform boundary evolved into thrusting within the Pacific Plate at ˜52-50 Ma, allowing it to subduct beneath the newly formed PSP, which was composed of an alternance of thick Mesozoic terranes and thin oceanic lithosphere. (4) The first magmas rising from the shallow mantle corner, after being hydrated by the subducting Pacific crust beneath the young oceanic crust near the upper plate spreading centers at ˜49-48 Ma were boninites. Both the so-called FABs and the boninites formed at a significant distance from the incipient trench, not in a fore-arc position as previously claimed. The magmas erupted for 15 m.y. in some places, probably near the intersections between back-arc spreading centers and the arc. (5) As the Pacific crust reached greater depths and the oceanic basins cooled and thickened at ˜44-45 Ma, the composition of the lavas evolved into high-Mg andesites and then arc tholeiites and calc-alkaline andesites. (6) Tectonic erosion processes removed about 150-200 km of frontal margin during the Neogene, consuming most or all of the Pacific ophiolite initially accreted to the PSP. The result was exposure of the FABs, boninites, and early volcanics that are near the trench today. (7) Serpentinite mud volcanoes observed in the Mariana fore-arc may have formed above the remnants of the paleo-transform boundary between the proto-PSP and the Pacific Plate.

On the kinematic criterion for the inception of breaking in surface gravity waves: Fully nonlinear numerical simulations and experimental verification

NASA Astrophysics Data System (ADS)

Khait, A.; Shemer, L.

2018-05-01

The evolution of unidirectional wave trains containing a wave that gradually becomes steep is evaluated experimentally and numerically using the Boundary Element Method (BEM). The boundary conditions for the nonlinear numerical simulations corresponded to the actual movements of the wavemaker paddle as recorded in the physical experiments, allowing direct comparison between the measured in experiments' characteristics of the wave train and the numerical predictions. The high level of qualitative and quantitative agreement between the measurements and simulations validated the kinematic criterion for the inception of breaking and the location of the spilling breaker, on the basis of the BEM computations and associated experiments. The breaking inception is associated with the fluid particle at the crest of the steep wave that has been accelerated to match and surpass the crest velocity. The previously observed significant slow-down of the crest while approaching breaking is verified numerically; both narrow-/broad-banded wave trains are considered. Finally, the relative importance of linear and nonlinear contributions is analyzed.

ZnO Nanowire-Based Corona Discharge Devices Operated Under Hundreds of Volts.

PubMed

Yang, Wenming; Zhu, Rong; Zong, Xianli

2016-12-01

Minimizing the voltage of corona discharges, especially when using nanomaterials, has been of great interest in the past decade or so. In this paper, we report a new corona discharge device by using ZnO nanowires operated in atmospheric air to realize continuous corona discharge excited by hundreds of volts. ZnO nanowires were synthesized on microelectrodes using electric-field-assisted wet chemical method, and a thin tungsten film was deposited on the microchip to enhance discharging performance. The testing results showed that the corona inception voltages were minimized greatly by using nanowires compared to conventional dischargers as a result of the local field enhancement of nanowires. The corona could be continuously generated and self-sustaining. It was proved that the law of corona inception voltage obeyed the conventional Peek's breakdown criterion. An optimal thickness of tungsten film coated over ZnO nanowires was figured out to obtain the lowest corona inception voltage. The ion concentration of the nanowire-based discharger attained 10(17)/m(3) orders of magnitude, which is practicable for most discharging applications.

A portal for the ocean biogeographic information system

USGS Publications Warehouse

Zhang, Yunqing; Grassle, J. F.

2002-01-01

Since its inception in 1999 the Ocean Biogeographic Information System (OBIS) has developed into an international science program as well as a globally distributed network of biogeographic databases. An OBIS portal at Rutgers University provides the links and functional interoperability among member database systems. Protocols and standards have been established to support effective communication between the portal and these functional units. The portal provides distributed data searching, a taxonomy name service, a GIS with access to relevant environmental data, biological modeling, and education modules for mariners, students, environmental managers, and scientists. The portal will integrate Census of Marine Life field projects, national data archives, and other functional modules, and provides for network-wide analyses and modeling tools.

Welcome to the Twilight Zone: a forgotten early phase of human evolutionary studies.

PubMed

Delisle, Richard G

2012-06-01

The field of paleoanthropology arose out of a strange and unacknowledged early phase of development prior to about the 1930s. It is often assumed that a key pillar of the discipline, the unity of humankind--the notion that humans are clearly separated phylogenetically (genealogically) from other non-human primates--was widely accepted from the inception of paleoanthropology around 1860. However, a final consensus on this fundamental question only appeared later on in the 20th century. This paper will focus on two key areas of disagreement, which reveal the unsettled state of this question during this early period: the question of uncertainty with respect to the number, identity and boundary of primate species (including humans) which prevailed in the 18th, 19th and early 20th centuries; and the matter of uncertainty with respect to the nature of the phylogenetic relationships among the various human populations and the other primate species which prevailed between 1864 and 1931. Consideration of these matters reveals that the modern research structure that paleoanthropologists take for granted today is much more recent than believed. Copyright © 2012 Elsevier Ltd. All rights reserved.

Influence of the capillary on the ignition of the transient spark discharge

NASA Astrophysics Data System (ADS)

Gerling, T.; Hoder, T.; Brandenburg, R.; Bussiahn, R.; Weltmann, K.-D.

2013-04-01

A self-pulsing negative dc discharge in argon generated in a needle-to-plane geometry at open atmosphere is investigated. Additionally, the needle electrode can be surrounded by a quartz capillary. It is shown that the relative position of the capillary end to the needle tip strongly influences the discharge inception and its spatio-temporal dynamics. Without the capillary for the selected working parameters a streamer corona is ignited, but when the capillary surrounds the needle, the transient spark (TS) discharge is ignited after a pre-streamer (PS) occurs. The time between PS and TS discharge depends on the relative capillary end position. The existence of the PS is confirmed by electro-optical characterization. Furthermore, spectrally and spatio-temporally resolved cross-correlation spectroscopy is applied to show the most active region of pre-phase emission activity as indicators for high local electric field strength. The results indicate that with a capillary in place, the necessary energy input of the pre-phase into the system is mainly reduced by additional electrical fields at the capillary edge. Even such a small change as a shift of dielectric surface close to the plasma largely changes the energy balance in the system.

Experimental investigation of hydrodynamic cavitation through orifices of different geometries

NASA Astrophysics Data System (ADS)

Rudolf, Pavel; Kubina, Dávid; Hudec, Martin; Kozák, Jiří; Maršálek, Blahoslav; Maršálková, Eliška; Pochylý, František

Hydrodynamic cavitation in single and multihole orifices was experimentally investigated to assess their hydraulic characteristics: loss coefficients, inception cavitation number, cavitation number for transition to supercavitation. Significant difference for singlehole and multihole orifices was observed in terms of the measured loss coefficient. It is significantly more effective to use multihole orifices, where energy dissipation is much lower.It was found that using scaling factor given by ratio of orifice thickness suggests linear behaviour of both loss coefficient and inception cavitation number. Orifices seem to be convenient choice as flow constriction devices inducing cavitation due to their simplicity.

Modeling & Informatics at Vertex Pharmaceuticals Incorporated: our philosophy for sustained impact

NASA Astrophysics Data System (ADS)

McGaughey, Georgia; Patrick Walters, W.

2017-03-01

Molecular modelers and informaticians have the unique opportunity to integrate cross-functional data using a myriad of tools, methods and visuals to generate information. Using their drug discovery expertise, information is transformed to knowledge that impacts drug discovery. These insights are often times formulated locally and then applied more broadly, which influence the discovery of new medicines. This is particularly true in an organization where the members are exposed to projects throughout an organization, such as in the case of the global Modeling & Informatics group at Vertex Pharmaceuticals. From its inception, Vertex has been a leader in the development and use of computational methods for drug discovery. In this paper, we describe the Modeling & Informatics group at Vertex and the underlying philosophy, which has driven this team to sustain impact on the discovery of first-in-class transformative medicines.

International Oil Supplies and Demands

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-04-01

The eleventh Energy Modeling Forum (EMF) working group met four times over the 1989--1990 period to compare alternative perspectives on international oil supplies and demands through 2010 and to discuss how alternative supply and demand trends influence the world's dependence upon Middle Eastern oil. Proprietors of eleven economic models of the world oil market used their respective models to simulate a dozen scenarios using standardized assumptions. From its inception, the study was not designed to focus on the short-run impacts of disruptions on oil markets. Nor did the working group attempt to provide a forecast or just a single viewmore » of the likely future path for oil prices. The model results guided the group's thinking about many important longer-run market relationships and helped to identify differences of opinion about future oil supplies, demands, and dependence.« less

International Oil Supplies and Demands

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-09-01

The eleventh Energy Modeling Forum (EMF) working group met four times over the 1989--90 period to compare alternative perspectives on international oil supplies and demands through 2010 and to discuss how alternative supply and demand trends influence the world's dependence upon Middle Eastern oil. Proprietors of eleven economic models of the world oil market used their respective models to simulate a dozen scenarios using standardized assumptions. From its inception, the study was not designed to focus on the short-run impacts of disruptions on oil markets. Nor did the working group attempt to provide a forecast or just a single viewmore » of the likely future path for oil prices. The model results guided the group's thinking about many important longer-run market relationships and helped to identify differences of opinion about future oil supplies, demands, and dependence.« less

Modeling of transmission line exposure to direct lightning strokes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rizk, F.A.M.

1990-10-01

The paper introduces a new model for assessing the exposure of free-standing structures and horizontal conductors above flat ground to direct lightning strokes. The starting point of this work is a recently developed criterion for positive leader inception, modified to account for positive leaders initiated under the influence of a negative descending lightning stroke. Subsequent propagation of the positive leader is analyzed to define the point of encounter of the two leaders which determines the attractive radius of a structure or the attractive lateral distance of a conductor. These parameters are investigated for a wide range of heights and return-strokemore » currents. A method for analyzing shielding failure and determining the critical shielding angle is also described. The predictions of the model are compared with field observations and previously developed models.« less

A linearized microstructural model for hydraulic conductivity evolution due to brittle damage: application to Hydraulic Fracturing treatments

NASA Astrophysics Data System (ADS)

Caramiello, G.; Montanino, A.; Della Vecchia, G., Sr.; Pandolfi, A., Sr.

2017-12-01

Among the features of geological structures, fractures and discontinuities play a dominant role, due to their significant influence on both the hydraulic and the mechanical behavior of the rock mass. Despite the current availability of fault and fracture mappings, the understanding of the influence of faults on fluid flow is nowadays not satisfactory, in particular when hydro-mechanical coupling is significant. In engineering technology fracture processes are often exploited. Hydraulic fracturing is one of the most important example. Hydraulic fracturing is a process characterized by the inception and propagation of fractures as a consequence of a hydraulic driven solicitation and it is used to improve the production and optimize well stimulation in low permeability reservoirs. Due to the coupling of several different phenomena (hydro-thermo-chemical coupling) there is not a reliable complete mathematical model able to simulate in a proper way the process. To design hydraulic fracturing treatments, it is necessary to predict the growth of fracture geometry as a function of treatment parameters. In this contribution we present a recently developed model of brittle damage of confined rock masses, with particular emphasis on the influence of mechanical damage on the evolution of porosity and permeability. The model is based on an explicit micromechanical construction of connected patterns of parallel equi-spaced cracks. A relevant feature of the model is that the fracture patterns are not arbitrary, but their inception, orientation and spacing follow from energetic consideration. The model, based on the Terzaghi effective stress concepts, has been then implemented into a coupled hydro-mechanical finite element code, where the linear momentum and the fluid mass balance equations are numerically solved via a staggered approach. The coupled code is used to simulate fracturing processes induced by an increase in pore pressure. The examples show the capability of the model in reproducing three-dimensional multiscale complex fracture patterns and permeability enhancement in the damaged porous medium. The numerical code, has been used to verify the influence of the distance between the different perforation slots as well of the wellbore-deviation from the minimum stress axis on the propagation of multiple.

The UK Haemophilia Doctors Organisation triennial audit of UK Comprehensive Care Haemophilia Centres.

PubMed

Wilde, J T

2012-07-01

Under the auspices of the United Kingdom Haemophilia Doctors Organisation (UKHCDO) the UK Comprehensive Care Haemophilia Centres (CCCs) have undergone a three yearly formal audit assessment since 1993. This report describes the evolution of the audit process and details the findings of the most recent audit round, the sixth since inception. The audit reports from the 2009 audit round were reviewed by the audit organizing group and a structured analysis of the data was compiled. CCCs in the UK offer a high standard of comprehensive care services. The main areas of concern were the state of the premises (seven centres), lack of dental services (seven centres), physiotherapy (seven centres) and social work support (11 centres). Major concerns were identified at eight centres requiring a formal letter from the chairman of UKHCDO to the chief executive of the host trust. Since inception of the triennial audit process centre report recommendations have resulted in major improvements in the services available at UK CCCs. The audit process is considered to be a highly effective means of improving the quality of care for patients with bleeding disorders and can be used as a model for the introduction of a similar process in other countries. © 2012 Blackwell Publishing Ltd.

On the possibility of ice on Greenland during the Eocene-Oligocene transition

NASA Astrophysics Data System (ADS)

Langebroek, Petra M.; Nisancioglu, Kerim H.; Lunt, Daniel J.; Kathrine Pedersen, Vivi; Nele Meckler, A.; Gasson, Edward

2017-04-01

The Eocene-Oligocene transition ( 34 Ma) is one of the major climate transitions of the Cenozoic era. Atmospheric CO2 decreased from the high levels of the Greenhouse world (>1000 ppm) to values of about 600-700 ppm in the early Oligocene. High latitude temperatures dropped by several degrees, causing a large-scale expansion of the Antarctic ice sheet. Concurrently, in the Northern Hemisphere, the inception of ice caps on Greenland is suggested by indirect evidence from ice-rafted debris and changes in erosional regime. However, ice sheet models have not been able to simulate extensive ice on Greenland under the warm climate of the Eocene-Oligocene transition. We show that elevated bedrock topography is key in solving this inconsistency. During the late Eocene / early Oligocene, East Greenland bedrock elevations were likely higher than today due to tectonic and deep-Earth processes related to the break-up of the North Atlantic and the position of the Icelandic plume. When allowing for higher initial bedrock topography, we do simulate a large ice cap on Greenland under the still relatively warm climate of the early Oligocene. Ice inception takes place at high elevations in the colder regions of North and Northeast Greenland; with the size of the ice cap being strongly dependent on the climate forcing and the bedrock topography applied.

The relative effects of cavitation and nonlinear ultrasound propagation on HIFU lesion dynamics in a tissue phantom

NASA Astrophysics Data System (ADS)

Khokhlova, Vera A.; Bailey, Michael R.; Reed, Justin; Kaczkowski, Peter J.

2004-05-01

The relative importance of the effects of acoustic nonlinearity and cavitation in HIFU lesion production is studied experimentally and theoretically in a polyacrylamide gel. A 2-MHz transducer of 40-mm diameter and 45-mm focal length was operated at different regimes of power, and in cw or duty-cycle regimes with equal mean intensity. Elevated static pressure was applied to suppress bubbles, increase boiling temperature, and thus to isolate the effect of acoustic nonlinearity in the enhancement of lesion production. Experimental data were compared with the results of simulations performed using a KZK acoustic model combined with the bioheat equation and thermal dose formulation. Boiling and the typical tadpole-shaped lesion shifting towards the transducer were observed under standard atmospheric pressure. No boiling was detected and a symmetric thermal lesion formed in the case of overpressure. A delay in lesion inception time was registered with overpressure, which was hypothesized to be due to suppressed microbubble dynamics. The effect of acoustic nonlinearity was revealed as a substantial decrease in the lesion inception time and an increase in the lesion size for high-amplitude waves under both standard and overpressure conditions. [Work supported by ONRIFO, NASA/NSBRI, NIH Fogarty, and CRDF grants.

Crohn's disease and ulcerative colitis are associated with elevated standardized mortality ratios: a meta-analysis.

PubMed

Bewtra, Meenakshi; Kaiser, Lisa M; TenHave, Tom; Lewis, James D

2013-03-01

Evidence regarding all-cause and cause-specific mortality in inflammatory bowel disease (IBD) is conflicting, and debate exists over appropriate study design to examine these important outcomes. We conducted a comprehensive meta-analysis of all-cause and cause-specific mortality in both Crohn's disease (CD) and ulcerative colitis (UC), and additionally examined various effects of study design on this outcome. A systematic search of PubMed and EMBASE was conducted to identify studies examining mortality rates relative to the general population. Pooled summary standardized mortality ratios (SMR) were calculated using random effect models. Overall, 35 original articles fulfilled the inclusion and exclusion criteria, reporting all-cause mortality SMRs varying from 0.44 to 7.14 for UC and 0.71 to 3.20 for CD. The all-cause mortality summary SMR for inception cohort and population cohort UC studies was 1.19 (95% confidence interval, 1.06-1.35). The all-cause mortality summary SMR for inception cohort and population cohort CD studies was 1.38 (95% confidence interval, 1.23-1.55). Mortality from colorectal cancer, pulmonary disease, and nonalcoholic liver disease was increased, whereas mortality from cardiovascular disease was decreased. Patients with UC and CD have higher rates of death from all causes, colorectal-cancer, pulmonary disease, and nonalcoholic liver disease.

Systematic Review and Meta-analysis: Placebo Rates in Induction and Maintenance Trials of Ulcerative Colitis

PubMed Central

Zou, Guangyong; Parker, Claire E.; Macdonald, John K.; Mosli, Mahmoud H.; Khanna, Reena; Shackelton, Lisa M.; Vandervoort, Margaret K.; AlAmeel, Turki; Al Beshir, Mohammad; AlMadi, Majid; Al-Taweel, Talal; Atkinson, Nathan S. S.; Biswas, Sujata; Chapman, Thomas P.; Dulai, Parambir S.; Glaire, Mark A.; Hoekman, Daniel; Koutsoumpas, Andreas; Minas, Elizabeth; Samaan, Mark A.; Travis, Simon; D’Haens, Geert; Levesque, Barrett G.; Sandborn, William J.; Feagan, Brian G.

2016-01-01

Background and Aims: Minimisation of the placebo responses in randomised controlled trials [RCTs] is essential for efficient evaluation of new interventions. Placebo rates have been high in ulcerative colitis [UC] clinical trials, and factors influencing this are poorly understood. We quantify placebo response and remission rates in UC RCTs and identify trial design factors influencing them. Methods: MEDLINE, EMBASE, and the Cochrane Library were searched from inception through April 2014 for placebo-controlled trials in adult patients with UC of a biological agent, corticosteroid, immunosuppressant, or aminosalicylate. Data were independently doubly extracted. Quality was assessed using the Cochrane risk of bias tool. Results: In all, 51 trials [48 induction and 10 maintenance phases] were identified. Placebo response and remission rates were pooled according to random-effects models, and mixed-effects meta-regression models were used to evaluate effects of study-level characteristics on these rates. Pooled estimates of placebo remission and response rates for induction trials were 10% (95% confidence interval [CI] 7-13%) and 33% [95% CI 29-37%], respectively. Corresponding values for maintenance trials were 19% [95% CI 11-30%] and 22% [95% CI 17-28%]. Trials enrolling patients with more active disease confirmed by endoscopy [endoscopy subscore ≥ 2] were associated with lower placebo rates. Conversely, placebo rates increased with increasing trial duration and number of study visits. Conclusions: Objective assessment of greater disease activity at trial entry by endoscopy lowered placebo rates, whereas increasing trial duration and more interactions with healthcare providers increased placebo rates. These findings have important implications for design and conduct of clinical trials. PMID:26746169

Simulation of the XV-15 tilt rotor research aircraft

NASA Technical Reports Server (NTRS)

Churchill, G. B.; Dugan, D. C.

1982-01-01

The effective use of simulation from issuance of the request for proposal through conduct of a flight test program for the XV-15 Tilt Rotor Research Aircraft is discussed. From program inception, simulation complemented all phases of XV-15 development. The initial simulation evaluations during the source evaluation board proceedings contributed significantly to performance and stability and control evaluations. Eight subsequent simulation periods provided major contributions in the areas of control concepts; cockpit configuration; handling qualities; pilot workload; failure effects and recovery procedures; and flight boundary problems and recovery procedures. The fidelity of the simulation also made it a valuable pilot training aid, as well as a suitable tool for military and civil mission evaluations. Simulation also provided valuable design data for refinement of automatic flight control systems. Throughout the program, fidelity was a prime issue and resulted in unique data and methods for fidelity evaluation which are presented and discussed.

Increasing productivity through Total Reuse Management (TRM)

NASA Technical Reports Server (NTRS)

Schuler, M. P.

1991-01-01

Total Reuse Management (TRM) is a new concept currently being promoted by the NASA Langley Software Engineering and Ada Lab (SEAL). It uses concepts similar to those promoted in Total Quality Management (TQM). Both technical and management personnel are continually encouraged to think in terms of reuse. Reuse is not something that is aimed for after a product is completed, but rather it is built into the product from inception through development. Lowering software development costs, reducing risk, and increasing code reliability are the more prominent goals of TRM. Procedures and methods used to adopt and apply TRM are described. Reuse is frequently thought of as only being applicable to code. However, reuse can apply to all products and all phases of the software life cycle. These products include management and quality assurance plans, designs, and testing procedures. Specific examples of successfully reused products are given and future goals are discussed.

Wavelet Based Protection Scheme for Multi Terminal Transmission System with PV and Wind Generation

NASA Astrophysics Data System (ADS)

Manju Sree, Y.; Goli, Ravi kumar; Ramaiah, V.

2017-08-01

A hybrid generation is a part of large power system in which number of sources usually attached to a power electronic converter and loads are clustered can operate independent of the main power system. The protection scheme is crucial against faults based on traditional over current protection since there are adequate problems due to fault currents in the mode of operation. This paper adopts a new approach for detection, discrimination of the faults for multi terminal transmission line protection in presence of hybrid generation. Transient current based protection scheme is developed with discrete wavelet transform. Fault indices of all phase currents at all terminals are obtained by analyzing the detail coefficients of current signals using bior 1.5 mother wavelet. This scheme is tested for different types of faults and is found effective for detection and discrimination of fault with various fault inception angle and fault impedance.

Paleoclimate reconstruction in the Levant region from the petrography and the geochemistry of a MIS 5 stalagmite from the Kanaan Cave, Lebanon

NASA Astrophysics Data System (ADS)

Nehme, C.; Verheyden, S.; Noble, S. R.; Farrant, A. R.; Delannoy, J. J.; Claeys, P.

2015-07-01

Lying at the transition between the temperate Mediterranean domain and subtropical deserts, the Levant is a key area to study the palaeoclimatic response over glacial-interglacial cycles. This paper presents a precisely dated last interglacial (MIS 5) stalagmite (129-84 ka) from the Kanaan Cave, Lebanon. Variations in growth rate and isotopic records indicate a warm humid phase at the onst of the last interglacial at ~129 ka that lasted until ~125 ka. A gradual shift in speleothem isotopic composition (125-122 ka) is driven mainly by the δ18O source effect of the Eastern Mediterranean surface waters during Sapropel S5. The onset of glacial inception began after ~122 ka, interrupted by a short wet pulse during Sapropel S4. Low growth rates and enriched oxygen and carbon values until ~84 ka indicate a transition to drier conditions during Northern Hemisphere glaciation.

Reconstruction of MIS 5 climate in the central Levant using a stalagmite from Kanaan Cave, Lebanon

NASA Astrophysics Data System (ADS)

Nehme, C.; Verheyden, S.; Noble, S. R.; Farrant, A. R.; Sahy, D.; Hellstrom, J.; Delannoy, J. J.; Claeys, P.

2015-12-01

Lying at the transition between the temperate Mediterranean domain and subtropical deserts, the Levant is a key area to study the palaeoclimatic response over glacial-interglacial cycles. This paper presents a precisely dated last interglacial (MIS 5) stalagmite (129-84 ka) from the Kanaan Cave, Lebanon. Variations in growth rate and isotopic records indicate a warm humid phase at the onset of the last interglacial at ~ 129 ka that lasted until ~ 125 ka. A gradual shift in speleothem isotopic composition (125-122 ka) is driven mainly by the δ18O source effect of the eastern Mediterranean surface waters during sapropel 5 (S5). The onset of glacial inception began after ~ 122 ka, interrupted by a short wet pulse during the sapropel 4 (S4) event. Low growth rates and enriched oxygen and carbon values until ~ 84 ka indicate a transition to drier conditions during Northern Hemisphere glaciation.

The power of a critical heat engine

PubMed Central

Campisi, Michele; Fazio, Rosario

2016-01-01

Since its inception about two centuries ago thermodynamics has sparkled continuous interest and fundamental questions. According to the second law no heat engine can have an efficiency larger than Carnot's efficiency. The latter can be achieved by the Carnot engine, which however ideally operates in infinite time, hence delivers null power. A currently open question is whether the Carnot efficiency can be achieved at finite power. Most of the previous works addressed this question within the Onsager matrix formalism of linear response theory. Here we pursue a different route based on finite-size-scaling theory. We focus on quantum Otto engines and show that when the working substance is at the verge of a second order phase transition diverging energy fluctuations can enable approaching the Carnot point without sacrificing power. The rate of such approach is dictated by the critical indices, thus showing the universal character of our analysis. PMID:27320127

Deep convolutional neural network for the classification of hepatocellular carcinoma and intrahepatic cholangiocarcinoma

NASA Astrophysics Data System (ADS)

Midya, Abhishek; Chakraborty, Jayasree; Pak, Linda M.; Zheng, Jian; Jarnagin, William R.; Do, Richard K. G.; Simpson, Amber L.

2018-02-01

Liver cancer is the second leading cause of cancer-related death worldwide.1 Hepatocellular carcinoma (HCC) is the most common primary liver cancer accounting for approximately 80% of cases. Intrahepatic cholangiocarcinoma (ICC) is a rare liver cancer, arising in patients with the same risk factors as HCC, but treatment options and prognosis differ. The diagnosis of HCC is based primarily on imaging but distinguishing between HCC and ICC is challenging due to common radiographic features.2-4 The aim of the present study is to classify HCC and ICC in portal venous phase CT. 107 patients with resected ICC and 116 patients with resected HCC were included in our analysis. We developed a deep neural network by modifying a pre-trained Inception network by retraining the final layers. The proposed method achieved the best accuracy and area under the receiver operating characteristics curve of 69.70% and 0.72, respectively on the test data.

Prediction of static friction coefficient in rough contacts based on the junction growth theory

NASA Astrophysics Data System (ADS)

Spinu, S.; Cerlinca, D.

2017-08-01

The classic approach to the slip-stick contact is based on the framework advanced by Mindlin, in which localized slip occurs on the contact area when the local shear traction exceeds the product between the local pressure and the static friction coefficient. This assumption may be too conservative in the case of high tractions arising at the asperities tips in the contact of rough surfaces, because the shear traction may be allowed to exceed the shear strength of the softer material. Consequently, the classic frictional contact model is modified in this paper so that gross sliding occurs when the junctions formed between all contacting asperities are independently sheared. In this framework, when the contact tractions, normal and shear, exceed the hardness of the softer material on the entire contact area, the material of the asperities yields and the junction growth process ends in all contact regions, leading to gross sliding inception. This friction mechanism is implemented in a previously proposed numerical model for the Cattaneo-Mindlin slip-stick contact problem, which is modified to accommodate the junction growth theory. The frictionless normal contact problem is solved first, then the tangential force is gradually increased, until gross sliding inception. The contact problems in the normal and in the tangential direction are successively solved, until one is stabilized in relation to the other. The maximum tangential force leading to a non-vanishing stick area is the static friction force that can be sustained by the rough contact. The static friction coefficient is eventually derived as the ratio between the latter friction force and the normal force.

Sooting Limits Of Diffusion Flames With Oxygen-Enriched Air And Diluted Fuel

NASA Technical Reports Server (NTRS)

Sunderland, P. B.; Urban, D. L.; Stocker, D. P.; Chao, B. H.; Axelbaum, R. L.

2003-01-01

Oxygen-enhanced combustion permits certain benefits and flexibility that are not otherwise available in the design of practical combustors, as discussed by Baukal. The cost of pure and enriched oxygen has declined to the point that oxygen-enhanced combustion is preferable to combustion in air for many applications. Carbon sequestration is greatly facilitated by oxygen enrichment because nitrogen can be eliminated from the product stream. For example, when natural gas (or natural gas diluted with CO2) is burned in pure oxygen, the only significant products are water and CO2. Oxygen-enhanced combustion also has important implications for soot formation, as explored in this work. We propose that soot inception in nonpremixed flames requires a region where C/O ratio, temperature, and residence time are above certain critical values. Soot does not form at low temperatures, with the threshold in nonpremixed flames ranging from about 1250-1650 K, a temperature referred to here as the critical temperature for soot inception, Tc. Soot inception also can be suppressed when residence time is short (equivalently, when the strain rate in counterflow flames is high). Soot induction times of 0.8-15 ms were reported by Tesner and Shurupov for acetylene/nitrogen mixtures at 1473 K. Burner stabilized spherical microgravity flames are employed in this work for two main reasons. First, this configuration offers unrestricted control over convection direction. Second, in steady state these flames are strain-free and thus can yield intrinsic sooting limits in diffusion flames, similar to the way past work in premixed flames has provided intrinsic values of C/O ratio associated with soot inception limits.

Ultrasound in telemedicine: its impact in high-risk obstetric health care delivery.

PubMed

Long, Megan Chang; Angtuaco, Teresita; Lowery, Curtis

2014-09-01

The aim of this study was to determine the impact of Antenatal and Neonatal Guidelines, Education, and Learning System (ANGELS), a statewide telemedicine project, on health care delivery to patients with high-risk pregnancies in Arkansas. With institutional review board approval, a Health Insurance Portability and Accountability Act-compliant retrospective review, in which the requirement for informed patient consent was waived, was performed. The population studied is the Arkansas maternal Medicaid population. Data for evaluation were collected from maternal Medicaid claims, ANGELS administrative records, and birth records from the Arkansas Vital Statistics record system. Data collected from before the inception of ANGELS (2001-2003) were compared with data collected after the inception of ANGELS (2004-2007).Antenatal and Neonatal Guidelines, Education, and Learning System is a multidisciplinary, multifaceted telemedicine program designed in Arkansas to enhance high-risk obstetric health care delivery across the state. An essential component of the program is real-time interactive targeted level II ultrasound examination of patients. Since the inception of the ANGELS program in 2003, a growing number of telemedicine consultations and real-time ultrasound examinations are being performed every year. The number and percentage of high-risk pregnancies identified each year show a slight decrease since inception of the ANGELS program, and findings suggest that identification of high-risk pregnancies is shifting from the second trimester to the first trimester, but trends vary over time. Antenatal and Neonatal Guidelines, Education, and Learning System has created a telemedicine network across the state that has made possible, among many other things, access to real-time level II ultrasound examinations and consultations. This program has ultimately led to improved prenatal access across the state.

Prognosis of acute idiopathic neck pain is poor: a systematic review and meta-analysis.

PubMed

Hush, Julia M; Lin, C Christine; Michaleff, Zoe A; Verhagen, Arianne; Refshauge, Kathryn M

2011-05-01

To conduct a systematic review and meta-analysis on the prognosis of acute idiopathic neck pain and disability. EMBASE, CINAHL, Medline, AMED, PEDro, and CENTRAL were searched from inception to July 2009, limited to human studies. Reference lists of relevant systematic reviews were searched by hand. Search terms included: neck pain, prognosis, inception, cohort, longitudinal, observational, or prospective study and randomized controlled trial. Eligible studies were longitudinal cohort studies and randomized controlled trials with a no treatment or minimal treatment arm that recruited an inception cohort of acute idiopathic neck pain and reported pain or disability outcomes. Eligibility was determined by 2 authors independently. Seven of 20,085 references were included. Pain and disability data were extracted independently by 2 authors. Risk of bias was assessed independently by 2 authors. Statistical pooling showed a weighted mean pain score (0-100) of 64 (95% confidence interval [CI], 61-67) at onset and 35 (95% CI, 32-38) at 6.5 weeks. At 12 months, neck pain severity remained high at 42 (95% CI, 39-45). Disability reduced from a pooled weighted mean score (0-100) at onset of 30 (95% CI, 28-32) to 17 (95% CI, 15-19) by 6.5 weeks, without further improvement at 12 months. Studies varied in length of follow-up, design, and sample size. This review provides Level I evidence that the prognosis of acute idiopathic neck pain is worse than currently recognized. This evidence can guide primary care clinicians when providing prognostic information to patients. Further research to identify prognostic factors and long-term outcomes from inception cohorts would be valuable. Copyright © 2011 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Prevalence and associated factors of low bone mass in adults with systemic lupus erythematosus.

PubMed

Cramarossa, G; Urowitz, M B; Su, J; Gladman, D; Touma, Z

2017-04-01

Background Systemic lupus erythematosus (SLE) patients are often treated with glucocorticoids, which place them at risk of bone loss. Objectives The objectives of this article are to determine: (1) the prevalence of low bone mineral density (BMD) and factors associated with low BMD and (2) the prevalence of symptomatic fragility fractures in inception patients of the Toronto Lupus Cohort (TLC). Methods Prospectively collected data from the TLC (1996-2015) of inception patients' first BMD were analyzed. For pre-menopausal women/males <50 years, BMD 'below expected range for age' was defined by Z-score ≤ -2.0 SD. For post-menopausal women/males age 50 or older, osteoporosis was defined by T-score ≤ -2.5 SD and low bone mass by T-score between -1.0 and -2.5 SD. Patients' BMDs were defined as abnormal if Z-score ≤ -2.0 or T-score < -1.0 SD, and the remainder as normal. Descriptive analysis and logistic regression were employed. Results Of 1807 patients, 286 are inception patients with BMD results (mean age 37.9 ± 13.7 years); 88.8% are female. The overall prevalence of abnormal BMD is 31.5%. In pre-menopausal women ( n = 173), the prevalence of BMD below expected range is 17.3%. In post-menopausal women ( n = 81), the prevalence of osteoporosis and low BMD are 12.3% and 43.2%, respectively. Age and cumulative dose of glucocorticoids are statistically significantly associated with abnormal BMD in multivariate analysis. Of 769 inception patients from TLC, 11.1% experienced symptomatic fragility fractures (peripheral and vertebral) over the course of their disease. Conclusion The prevalence of low BMD is high in SLE patients, and is associated with older age and higher cumulative glucocorticoid dose.

Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers.

PubMed

DeVries, Avery; Wlasiuk, Gabriela; Miller, Susan J; Bosco, Anthony; Stern, Debra A; Lohman, I Carla; Rothers, Janet; Jones, Anya C; Nicodemus-Johnson, Jessie; Vasquez, Monica M; Curtin, John A; Simpson, Angela; Custovic, Adnan; Jackson, Daniel J; Gern, James E; Lemanske, Robert F; Guerra, Stefano; Wright, Anne L; Ober, Carole; Halonen, Marilyn; Vercelli, Donata

2017-08-01

The timing and mechanisms of asthma inception remain imprecisely defined. Although epigenetic mechanisms likely contribute to asthma pathogenesis, little is known about their role in asthma inception. We sought to assess whether the trajectory to asthma begins already at birth and whether epigenetic mechanisms, specifically DNA methylation, contribute to asthma inception. We used the Methylated CpG Island Recovery Assay chip to survey DNA methylation in cord blood mononuclear cells from 36 children (18 nonasthmatic and 18 asthmatic subjects by age 9 years) from the Infant Immune Study (IIS), an unselected birth cohort closely monitored for asthma for a decade. SMAD3 methylation in IIS (n = 60) and in 2 replication cohorts (the Manchester Asthma and Allergy Study [n = 30] and the Childhood Origins of Asthma Study [n = 28]) was analyzed by using bisulfite sequencing or Illumina 450K arrays. Cord blood mononuclear cell-derived IL-1β levels were measured by means of ELISA. Neonatal immune cells harbored 589 differentially methylated regions that distinguished IIS children who did and did not have asthma by age 9 years. In all 3 cohorts methylation in SMAD3, the most connected node within the network of asthma-associated, differentially methylated regions, was selectively increased in asthmatic children of asthmatic mothers and was associated with childhood asthma risk. Moreover, SMAD3 methylation in IIS neonates with maternal asthma was strongly and positively associated with neonatal production of IL-1β, an innate inflammatory mediator. The trajectory to childhood asthma begins at birth and involves epigenetic modifications in immunoregulatory and proinflammatory pathways. Maternal asthma influences epigenetic mechanisms that contribute to the inception of this trajectory. Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

A revised subduction inception model to explain the Late Cretaceous, doubly vergent orogen in the pre-collisional western Tethys: evidences from the Northern Apennine

NASA Astrophysics Data System (ADS)

Meneghini, Francesca; Marroni, Michele; Pandolfi, Luca

2017-04-01

Orogenic processes are widely demonstrated to be strongly controlled by inherited structures. The paleogeography of the converging margins, and the tectonic processes responsible for their configuration, will influence the location of subduction initiation, the distribution of deformation between upper and lower plate, the shape of the accretionary prism and of the subsequent orogeny, through controlling the development of single or doubly-vergent orogens, and, as a corollary, the modality of exhumation of metamorphosed units. The "alpine age" collisional belts of the Mediterranean area are characterized by tangled architectures derived from the overlapping of several deformation events related to a multiphase, long history that comprises not only the collision of continental margins, but that can be regarded as an heritage of both the rifting-related configuration of the continental margins, and the subduction-related structures. The Northern Apennines is a segment of these collisional belts that originated by the Late Cretaceous-Middle Eocene closure of the northern branch of the western Tethys, and the subsequent Late Eocene-Early Oligocene continental collision between the Europe and Adria plates. Due to a different configuration of the paired Adria and Europe continental margins, inherited from a rifting phase dominated by asymmetric, simple-shear kinematics, the Northern Apennines expose a complex groups of units, referred to as Ligurian Units, that record the incorporation into the subduction factory of either fragments of the Ligure-Piemontese oceanic domain (i.e. Internal Ligurian Units), and various portions of the thinned Adria margin (i.e. External Ligurian Units), describable as an Ocean-Continent Transition Zone (OCTZ). The structural relationships between these groups of Units are crucial for the definition of the pre-collisional evolution of the belt and have been the subject of big debates in the literature, together with the location and orientation of subduction initiation. We have reviewed the ages and characteristics of the tectono-metamorphic events recorded in both the External and Internal Ligurian Units. Deformation and metamorphism in the External Ligurian Units pre-dates the subduction-related metamorphism recorded in the ocean-derived Internal Ligurian Units. We thus propose that closure of the Ligure-Piemontese branch of the western Tethys occurred through a subduction that nucleated inside the OCTZ of Adria, instead of localizing at the boundary between the oceanic basin and the Adria margin, and developed a doubly-vergent prism fed firstly by both continental extensional allochthons and ocean-derived rocks from the OCTZ, and only after by rocks and sediments from the oceanic realm. We believe that this revised location of the inception of subduction, and the subsequent pre-collisional architecture, considered as inherited from the rifting and the oceanic opening phases, allow reconciling most of the controversies on the geodynamic evolution of the Apenninic orogeny, prior to collision.

The Novel Antipsychotic Cariprazine (RGH-188): State-of-the-Art in the Treatment of Psychiatric Disorders.

PubMed

De Berardis, Domenico; Orsolini, Laura; Iasevoli, Felice; Prinzivalli, Emiliano; de Bartolomeis, Andrea; Serroni, Nicola; Mazza, Monica; Valchera, Alessandro; Fornaro, Michele; Vecchiotti, Roberta; Carano, Alessandro; Sepede, Gianna; Vellante, Federica; Matarazzo, Ilaria; Pompili, Maurizio; Perna, Giampaolo; Conti, Chiara; Segura-García, Cristina; Martinotti, Giovanni; Di Giannantonio, Massimo

2016-01-01

Cariprazine (RGH-188) is a novel antipsychotic drug that exerts partial agonism of dopamine D2/D3 receptors with preferential binding to D3 receptor, antagonism of 5HT2B receptors and partial agonism of 5HT1A. Currently, cariprazine is in late-stage clinical development (phase III clinical trials) in patients with schizophrenia (S) and in patients with bipolar disorder (BD), as well as an adjunctive treatment in patients with Major Depressive Disorder (MDD) and drug-resistant MDD. Cariprazine has completed phase III trials for the acute treatment of schizophrenia and bipolar mania, phase II trials for the bipolar depression and MDD whilst it is undergoing phase III trials as an adjunct to antidepressants. The present review aims at proving a comprehensive summary of the current evidence on the safety, tolerability and efficacy of cariprazine in the treatment of schizophrenia, BD (manic/mixed/ depressive episode) and MDD. A systematic search was conducted on PubMed/Medline/ Scopus and the database on Clinical Trials from inception until April 2015 by typing a set of specified keywords. Available evidence seems to support cariprazine efficacy in the treatment of cognitive and negative symptoms of schizophrenia. Preliminary findings suggest its antimanic activity whilst it is still under investigation its efficacy in the treatment of bipolar depression and MDD. Furthermore, the available data seems not to allow judgements about its antipsychotic potential in comparison with currently prescribed antipsychotics. Further studies should be carried out to better investigate its pharmacodynamic and clinical potential, particularly as alternative to current antipsychotic drugs.

Biology is Destiny: A Case of Adrenocortical Carcinoma Diagnosed and Resected at Inception in a Patient Under Close Surveillance for Lung Cancer.

PubMed

Miron, Benjamin; Ristau, Benjamin T; Tomaszewski, Jeffrey J; Jones, Josh; Milestone, Bart; Wong, Yu-Ning; Uzzo, Robert G; Edmondson, Donna; Scott, Walter; Kutikov, Alexander

2016-11-01

Adrenocortical carcinoma (ACC) is a rare malignancy that is generally associated with a poor prognosis whose existence dictates the management of incidental renal masses. We report a case of ACC diagnosed and treated at its apparent inception in a patient undergoing close surveillance imaging of a prior malignancy. Despite timely detection and resection of a localized ACC this patient rapidly progressed to systemic disease. This case highlights the rapid growth kinetics of ACC and puts into perspective the challenges associated with the established treatment paradigm for patients diagnosed with an adrenal mass.

Mechanism of Small Current Generation under Impulse Voltage Applications in Vacuum

NASA Astrophysics Data System (ADS)

Aoki, Keita; Yasukawa, Hideaki; Kojima, Hiroki; Homma, Mitsutaka; Shioiri, Tetsu; Okubo, Hitoshi

Small discharge not to accompany breakdown can occur under high electric field in vacuum, however the mechanism is not well clarified. We have found that the current of small discharge decreases with repeated voltage applications, and leads to electrode conditioning effect of raising withstand voltage. The inception of the current is delayed with the decrease of current, and the inception time and waveform change by gap length. On the other hand, under low vacuum condition, the current increases and reaches saturation with repeated voltage applications. From these discussions, we concluded that the generating process of small current depended on the adsorption and absorption gas of electrodes.

Objections to routine clinical outcomes measurement in mental health services: any evidence so far?

PubMed

MacDonald, Alastair J D; Trauer, Tom

2010-12-01

Routine clinical outcomes measurement (RCOM) is gaining importance in mental health services. To examine whether criticisms published in advance of the development of RCOM have been borne out by data now available from such a programme. This was an observational study of routine ratings using HoNOS65+ at inception/admission and again at discharge in an old age psychiatry service from 1997 to 2008. Testable hypotheses were generated from each criticism amenable to empirical examination. Inter-rater reliability estimates were applied to observed differences between scores between community and ward patients using resampling. Five thousand one hundred eighty community inceptions and 862 admissions had HoNOS65+ ratings at referral/admission and discharge. We could find no evidence of gaming (artificially worse scores at inception and better at discharge), selection, attrition or detection bias, and ratings were consistent with diagnosis and level of service. Anticipated low levels of inter-rater reliability did not vitiate differences between levels of service. Although only hypotheses testable from within RCOM data were examined, and only 46% of eligible episodes had complete outcomes data, no evidence of the alleged biases were found. RCOM seems valid and practical in mental health services.

A Thermal Runaway Failure Model for Low-Voltage BME Ceramic Capacitors with Defects

NASA Technical Reports Server (NTRS)

Teverovsky, Alexander

2017-01-01

Reliability of base metal electrode (BME) multilayer ceramic capacitors (MLCCs) that until recently were used mostly in commercial applications, have been improved substantially by using new materials and processes. Currently, the inception of intrinsic wear-out failures in high quality capacitors became much greater than the mission duration in most high-reliability applications. However, in capacitors with defects degradation processes might accelerate substantially and cause infant mortality failures. In this work, a physical model that relates the presence of defects to reduction of breakdown voltages and decreasing times to failure has been suggested. The effect of the defect size has been analyzed using a thermal runaway model of failures. Adequacy of highly accelerated life testing (HALT) to predict reliability at normal operating conditions and limitations of voltage acceleration are considered. The applicability of the model to BME capacitors with cracks is discussed and validated experimentally.

Interstellar Polycyclic Aromatic Compounds and Astrophysics

NASA Technical Reports Server (NTRS)

Hudgins, Douglas M.; DeVincenzi, Donald (Technical Monitor)

2001-01-01

Over the past fifteen years, thanks to significant, parallel advancements in observational, experimental, and theoretical techniques, tremendous strides have been made in our understanding of the role polycyclic aromatic compounds (PAC) in the interstellar medium (ISM). Twenty years ago, the notion of an abundant population of large, carbon rich molecules in the ISM was considered preposterous. Today, the unmistakable spectroscopic signatures of PAC - shockingly large molecules by previous interstellar chemistry standards - are recognized throughout the Universe. In this paper, we will examine the interstellar PAC model and its importance to astrophysics, including: (1) the evidence which led to inception of the model; (2) the ensuing laboratory and theoretical studies of the fundamental spectroscopic properties of PAC by which the model has been refined and extended; and (3) a few examples of how the model is being exploited to derive insight into the nature of the interstellar PAC population.

International Oil Supplies and Demands. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-09-01

The eleventh Energy Modeling Forum (EMF) working group met four times over the 1989--90 period to compare alternative perspectives on international oil supplies and demands through 2010 and to discuss how alternative supply and demand trends influence the world`s dependence upon Middle Eastern oil. Proprietors of eleven economic models of the world oil market used their respective models to simulate a dozen scenarios using standardized assumptions. From its inception, the study was not designed to focus on the short-run impacts of disruptions on oil markets. Nor did the working group attempt to provide a forecast or just a single viewmore » of the likely future path for oil prices. The model results guided the group`s thinking about many important longer-run market relationships and helped to identify differences of opinion about future oil supplies, demands, and dependence.« less

International Oil Supplies and Demands. Volume 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-04-01

The eleventh Energy Modeling Forum (EMF) working group met four times over the 1989--1990 period to compare alternative perspectives on international oil supplies and demands through 2010 and to discuss how alternative supply and demand trends influence the world`s dependence upon Middle Eastern oil. Proprietors of eleven economic models of the world oil market used their respective models to simulate a dozen scenarios using standardized assumptions. From its inception, the study was not designed to focus on the short-run impacts of disruptions on oil markets. Nor did the working group attempt to provide a forecast or just a single viewmore » of the likely future path for oil prices. The model results guided the group`s thinking about many important longer-run market relationships and helped to identify differences of opinion about future oil supplies, demands, and dependence.« less

Radiology Consultation in the Era of Precision Oncology: A Review of Consultation Models and Services in the Tertiary Setting.

PubMed

DiPiro, Pamela J; Krajewski, Katherine M; Giardino, Angela A; Braschi-Amirfarzan, Marta; Ramaiya, Nikhil H

2017-01-01

The purpose of the article is to describe the various radiology consultation models in the Era of Precision Medicine. Since the inception of our specialty, radiologists have served as consultants to physicians of various disciplines. A variety of radiology consultation services have been described in the literature, including clinical decision support, patient-centric, subspecialty interpretation, and/or some combination of these. In oncology care in particular, case complexity often merits open dialogue with clinical providers. To explore the utility and impact of radiology consultation services in the academic setting, this article will further describe existing consultation models and the circumstances that precipitated their development. The hybrid model successful at our tertiary cancer center is discussed. In addition, the contributions of a consultant radiologist in breast cancer care are reviewed as the archetype of radiology consultation services provided to oncology practitioners.

ClearTK 2.0: Design Patterns for Machine Learning in UIMA

PubMed Central

Bethard, Steven; Ogren, Philip; Becker, Lee

2014-01-01

ClearTK adds machine learning functionality to the UIMA framework, providing wrappers to popular machine learning libraries, a rich feature extraction library that works across different classifiers, and utilities for applying and evaluating machine learning models. Since its inception in 2008, ClearTK has evolved in response to feedback from developers and the community. This evolution has followed a number of important design principles including: conceptually simple annotator interfaces, readable pipeline descriptions, minimal collection readers, type system agnostic code, modules organized for ease of import, and assisting user comprehension of the complex UIMA framework. PMID:29104966

ClearTK 2.0: Design Patterns for Machine Learning in UIMA.

PubMed

Bethard, Steven; Ogren, Philip; Becker, Lee

2014-05-01

ClearTK adds machine learning functionality to the UIMA framework, providing wrappers to popular machine learning libraries, a rich feature extraction library that works across different classifiers, and utilities for applying and evaluating machine learning models. Since its inception in 2008, ClearTK has evolved in response to feedback from developers and the community. This evolution has followed a number of important design principles including: conceptually simple annotator interfaces, readable pipeline descriptions, minimal collection readers, type system agnostic code, modules organized for ease of import, and assisting user comprehension of the complex UIMA framework.

The role of charged particles in the positive corona-generated photon count in a rod to plane air gap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bian, X. M.; Wang, Y. J.; MacAlpine, J. M. K.

The relationship between the calculated charged-particle densities in positive corona, the rate of streamer production, and the photon count from the corona were investigated and found to be closely related. Both the densities of electrons and positive ions peaked at 11.8 kV, near the corona inception voltage; they then fell rapidly before slowly rising again. This behavior was exactly matched by the measured photon count. The calculation of the charged-particle density in a positive corona was achieved by means of a fluid model.

Trends in tissue engineering research.

PubMed

Hacker, Michael C; Mikos, Antonios G

2006-08-01

For more than a decade, Tissue Engineering has been devoted to the reporting and discussion of scientific advances in the interdisciplinary field of tissue engineering. In this study, 779 original articles published in the journal since its inception were analyzed and classified according to different attributes, such as focus of research and tissue of interest, to reveal trends in tissue engineering research. In addition, the use of different biomaterials, scaffold architectures, surface and bulk modification agents, cells, differentiation factors, gene delivery vectors, and animal models was examined. The results of this survey show interesting trends over time and by continental origin.

Home Oxygen Program review: Regionalization in Vancouver Coastal Health and British Columbia.

PubMed

Sandberg, Dan

2015-01-01

Since its inception in the 1980s, the Home Oxygen Program in British Columbia was centrally managed by the Ministry of Health. Initially a small program with few clients across the province, it soon became a large program with many clients and increasing expenditures. A pilot program started in Victoria (British Columbia) in 1996 demonstrated that managing the program locally could offer better client care, better contract management and significant cost savings. In 2002, the pilot's model and recommendations were implemented in British Columbia's five health authorities. The present review details the experiences of regionalizing the program in the Vancouver Coastal Health authority. After fine adjustments to the model were developed and new contracts and criteria changes made, better care for clients was provided than the previous centralized model at a reduced cost to the taxpayer.

The 30-year evolution of airway pressure release ventilation (APRV).

PubMed

Jain, Sumeet V; Kollisch-Singule, Michaela; Sadowitz, Benjamin; Dombert, Luke; Satalin, Josh; Andrews, Penny; Gatto, Louis A; Nieman, Gary F; Habashi, Nader M

2016-12-01

Airway pressure release ventilation (APRV) was first described in 1987 and defined as continuous positive airway pressure (CPAP) with a brief release while allowing the patient to spontaneously breathe throughout the respiratory cycle. The current understanding of the optimal strategy to minimize ventilator-induced lung injury is to "open the lung and keep it open". APRV should be ideal for this strategy with the prolonged CPAP duration recruiting the lung and the minimal release duration preventing lung collapse. However, APRV is inconsistently defined with significant variation in the settings used in experimental studies and in clinical practice. The goal of this review was to analyze the published literature and determine APRV efficacy as a lung-protective strategy. We reviewed all original articles in which the authors stated that APRV was used. The primary analysis was to correlate APRV settings with physiologic and clinical outcomes. Results showed that there was tremendous variation in settings that were all defined as APRV, particularly CPAP and release phase duration and the parameters used to guide these settings. Thus, it was impossible to assess efficacy of a single strategy since almost none of the APRV settings were identical. Therefore, we divided all APRV studies divided into two basic categories: (1) fixed-setting APRV (F-APRV) in which the release phase is set and left constant; and (2) personalized-APRV (P-APRV) in which the release phase is set based on changes in lung mechanics using the slope of the expiratory flow curve. Results showed that in no study was there a statistically significant worse outcome with APRV, regardless of the settings (F-ARPV or P-APRV). Multiple studies demonstrated that P-APRV stabilizes alveoli and reduces the incidence of acute respiratory distress syndrome (ARDS) in clinically relevant animal models and in trauma patients. In conclusion, over the 30 years since the mode's inception there have been no strict criteria in defining a mechanical breath as being APRV. P-APRV has shown great promise as a highly lung-protective ventilation strategy.

Research data management in academic institutions: A scoping review.

PubMed

Perrier, Laure; Blondal, Erik; Ayala, A Patricia; Dearborn, Dylanne; Kenny, Tim; Lightfoot, David; Reka, Roger; Thuna, Mindy; Trimble, Leanne; MacDonald, Heather

2017-01-01

The purpose of this study is to describe the volume, topics, and methodological nature of the existing research literature on research data management in academic institutions. We conducted a scoping review by searching forty literature databases encompassing a broad range of disciplines from inception to April 2016. We included all study types and data extracted on study design, discipline, data collection tools, and phase of the research data lifecycle. We included 301 articles plus 10 companion reports after screening 13,002 titles and abstracts and 654 full-text articles. Most articles (85%) were published from 2010 onwards and conducted within the sciences (86%). More than three-quarters of the articles (78%) reported methods that included interviews, cross-sectional, or case studies. Most articles (68%) included the Giving Access to Data phase of the UK Data Archive Research Data Lifecycle that examines activities such as sharing data. When studies were grouped into five dominant groupings (Stakeholder, Data, Library, Tool/Device, and Publication), data quality emerged as an integral element. Most studies relied on self-reports (interviews, surveys) or accounts from an observer (case studies) and we found few studies that collected empirical evidence on activities amongst data producers, particularly those examining the impact of research data management interventions. As well, fewer studies examined research data management at the early phases of research projects. The quality of all research outputs needs attention, from the application of best practices in research data management studies, to data producers depositing data in repositories for long-term use.

Assessing cognitive processes related to insomnia: A review and measurement guide for Harvey's cognitive model for the maintenance of insomnia.

PubMed

Hiller, Rachel M; Johnston, Anna; Dohnt, Hayley; Lovato, Nicole; Gradisar, Michael

2015-10-01

Cognitive processes play an important role in the maintenance, and treatment of sleep difficulties, including insomnia. In 2002, a comprehensive model was proposed by Harvey. Since its inception the model has received >300 citations, and provided researchers and clinicians with a framework for understanding and treating insomnia. The aim of this review is two-fold. First, we review the current literature investigating each factor proposed in Harvey's cognitive model of insomnia. Second, we summarise the psychometric properties of key measures used to assess the model's factors and mechanisms. From these aims, we demonstrate both strengths and limitations of the current knowledge of appropriate measurements associated with the model. This review aims to stimulate and guide future research in this area; and provide an understanding of the resources available to measure, target, and resolve cognitive factors that may maintain chronic insomnia. Copyright © 2014 Elsevier Ltd. All rights reserved.

Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.

PubMed

Kugathasan, Subra; Denson, Lee A; Walters, Thomas D; Kim, Mi-Ok; Marigorta, Urko M; Schirmer, Melanie; Mondal, Kajari; Liu, Chunyan; Griffiths, Anne; Noe, Joshua D; Crandall, Wallace V; Snapper, Scott; Rabizadeh, Shervin; Rosh, Joel R; Shapiro, Jason M; Guthery, Stephen; Mack, David R; Kellermayer, Richard; Kappelman, Michael D; Steiner, Steven; Moulton, Dedrick E; Keljo, David; Cohen, Stanley; Oliva-Hemker, Maria; Heyman, Melvin B; Otley, Anthony R; Baker, Susan S; Evans, Jonathan S; Kirschner, Barbara S; Patel, Ashish S; Ziring, David; Trapnell, Bruce C; Sylvester, Francisco A; Stephens, Michael C; Baldassano, Robert N; Markowitz, James F; Cho, Judy; Xavier, Ramnik J; Huttenhower, Curtis; Aronow, Bruce J; Gibson, Greg; Hyams, Jeffrey S; Dubinsky, Marla C

2017-04-29

Stricturing and penetrating complications account for substantial morbidity and health-care costs in paediatric and adult onset Crohn's disease. Validated models to predict risk for complications are not available, and the effect of treatment on risk is unknown. We did a prospective inception cohort study of paediatric patients with newly diagnosed Crohn's disease at 28 sites in the USA and Canada. Genotypes, antimicrobial serologies, ileal gene expression, and ileal, rectal, and faecal microbiota were assessed. A competing-risk model for disease complications was derived and validated in independent groups. Propensity-score matching tested the effect of anti-tumour necrosis factor α (TNFα) therapy exposure within 90 days of diagnosis on complication risk. Between Nov 1, 2008, and June 30, 2012, we enrolled 913 patients, 78 (9%) of whom experienced Crohn's disease complications. The validated competing-risk model included age, race, disease location, and antimicrobial serologies and provided a sensitivity of 66% (95% CI 51-82) and specificity of 63% (55-71), with a negative predictive value of 95% (94-97). Patients who received early anti-TNFα therapy were less likely to have penetrating complications (hazard ratio [HR] 0·30, 95% CI 0·10-0·89; p=0·0296) but not stricturing complication (1·13, 0·51-2·51; 0·76) than were those who did not receive early anti-TNFα therapy. Ruminococcus was implicated in stricturing complications and Veillonella in penetrating complications. Ileal genes controlling extracellular matrix production were upregulated at diagnosis, and this gene signature was associated with stricturing in the risk model (HR 1·70, 95% CI 1·12-2·57; p=0·0120). When this gene signature was included, the model's specificity improved to 71%. Our findings support the usefulness of risk stratification of paediatric patients with Crohn's disease at diagnosis, and selection of anti-TNFα therapy. Crohn's and Colitis Foundation of America, Cincinnati Children's Hospital Research Foundation Digestive Health Center. Copyright © 2017 Elsevier Ltd. All rights reserved.

Effects of Flame Structure and Hydrodynamics on Soot Particle Inception and Flame Extinction in Diffusion Flames

NASA Technical Reports Server (NTRS)

Axelbaum, R. L.; Chen, R.; Sunderland, P. B.; Urban, D. L.; Liu, S.; Chao, B. H.

2001-01-01

This paper summarizes recent studies of the effects of stoichiometric mixture fraction (structure) and hydrodynamics on soot particle inception and flame extinction in diffusion flames. Microgravity experiments are uniquely suited for these studies because, unlike normal gravity experiments, they allow structural and hydrodynamic effects to be independently studied. As part of this recent flight definition program, microgravity studies have been performed in the 2.2 second drop tower. Normal gravity counterflow studies also have been employed and analytical and numerical models have been developed. A goal of this program is to develop sufficient understanding of the effects of flame structure that flames can be "designed" to specifications - consequently, the program name Flame Design. In other words, if a soot-free, strong, low temperature flame is required, can one produce such a flame by designing its structure? Certainly, as in any design, there will be constraints imposed by the properties of the available "materials." For hydrocarbon combustion, the base materials are fuel and air. Additives could be considered, but for this work only fuel, oxygen and nitrogen are considered. Also, the structure of these flames is "designed" by varying the stoichiometric mixture fraction. Following this line of reasoning, the studies described are aimed at developing the understanding of flame structure that is needed to allow for optimum design.

Blood manganese as an exposure biomarker: State of the evidence

PubMed Central

Baker, Marissa G.; Simpson, Christopher D.; Stover, Bert; Sheppard, Lianne; Checkoway, Harvey; Racette, Brad A.; Seixas, Noah S.

2014-01-01

Despite evidence of adverse health effects resulting from exposure to manganese (Mn), biomarkers of exposure are poorly understood. To enhance understanding, mean blood Mn (MnB) and mean air Mn (MnA) were extracted from 63 exposure groups in 24 published papers, and the relationship was modeled using segmented regression. On a log/log scale, a positive association between MnA and MnB was observed among studies reporting MnA concentrations above about 10 μg/m3, although interpretation is limited by largely cross-sectional data, study design variability, and differences in exposure monitoring methods. Based on the results of the segmented regression, we hypothesize that below the concentration of about 10 μg/m3, Mn in the body is dominated by dietary Mn, and additional inhaled Mn only causes negligible changes in Mn levels unless the inhaled amount is substantial. However, stronger study designs are required to account for temporal characteristics of the MnA to MnB relationships which reflect the underlying physiology and toxicokinetics of Mn uptake and distribution. Thus, we present an inception cohort study design we have conducted among apprentice welders, and the analytical strengths this study design offers. To determine if blood could be a useful biomarker for Mn to be utilized by industrial hygienists in general industry requires additional time-specific analyses, which our inception cohort study design will allow. PMID:24579750

Cavitation noise studies on marine propellers

NASA Astrophysics Data System (ADS)

Sharma, S. D.; Mani, K.; Arakeri, V. H.

1990-04-01

Experimental observations are described of cavitation inception and noise from five model propellers, three basic and two modified, tested in the open jet section of the Indian Institute of Science high-speed water tunnel facility. Extensive experiments on the three basic propellers of different design, which included visualization of cavitation and measurements of noise, showed that the dominant type of cavitation was in the form of tip vortex cavitation, accompanied by leading edge suction side sheet cavitation in its close vicinity, and the resultant noise depended on parameters such as the advance coefficient, the cavitation number, and the propeller geometry. Of these, advance coefficient was found to have the maximum influence not only on cavitation noise but also on the inception of cavitation. Noise levels and frequencies of spectra obtained from all the three basic propellers at conditions near inception and different advance coefficient values, when plotted in the normalized form as suggested by Blake, resulted in a universal spectrum which would be useful for predicting cavitation noise at prototype scales when a limited extent of cavitation is expected in the same form as observed on the present models. In an attempt to delay the onset of tip vortex cavitation, the blades of two of the three basic propellers were modified by drilling small holes in the tip and leading edge areas. Studies on the modified propellers showed that the effectiveness of the blade modification was apparently stronger at low advance coefficient values and depended on the blade sectional profile. Measurements of cavitation noise indicated that the modification also improved the acoustic performance of the propellers as it resulted in a complete attenuation of the low-frequency spectral peaks, which were prominent with the basic propellers. In addition to the above studies, which were conducted under uniform flow conditions, one of the basic propellers was tested in the simulated wake of a typical single screw ship. The wake was simulated by using a wire screen technique. Observations of cavitation and measurement of noise clearly showed that the presence of the wake had a strong influence on the propeller cavitation and noise performance. Cavitation was found to be of the cloud type, which generated very intense noise compared to that generated by tip vortex cavitation along with leading edge suction side sheet cavitation in the uniform flow conditions. The noise spectra obtained with wake simulation also are presented in a normalized form to be of general utility.

The EZ diffusion model provides a powerful test of simple empirical effects.

PubMed

van Ravenzwaaij, Don; Donkin, Chris; Vandekerckhove, Joachim

2017-04-01

Over the last four decades, sequential accumulation models for choice response times have spread through cognitive psychology like wildfire. The most popular style of accumulator model is the diffusion model (Ratcliff Psychological Review, 85, 59-108, 1978), which has been shown to account for data from a wide range of paradigms, including perceptual discrimination, letter identification, lexical decision, recognition memory, and signal detection. Since its original inception, the model has become increasingly complex in order to account for subtle, but reliable, data patterns. The additional complexity of the diffusion model renders it a tool that is only for experts. In response, Wagenmakers et al. (Psychonomic Bulletin & Review, 14, 3-22, 2007) proposed that researchers could use a more basic version of the diffusion model, the EZ diffusion. Here, we simulate experimental effects on data generated from the full diffusion model and compare the power of the full diffusion model and EZ diffusion to detect those effects. We show that the EZ diffusion model, by virtue of its relative simplicity, will be sometimes better able to detect experimental effects than the data-generating full diffusion model.

Tip-leakage cavitation in the clearance of a 2D hydrofoil with fillets: high-speed visualization and PIV/PTV measurements

NASA Astrophysics Data System (ADS)

Zapryagaev, Ivan I.; Timoshevskiy, Mikhail V.; Pervunin, Konstantin S.

2017-09-01

Tip-clearance cavitation is one of the most aggressive forms of cavitation as it can cause surface erosion of hydraulic machinery elements and, as a result, their fatigue damage and disturb designed operating conditions. At present, the literature lacks for detailed experimental data on the inception and development of this type of cavitation at various flow conditions. In the paper, a tip-leakage cavitation occurring in the clearance between an end face of a 2D hydrofoil (a scaled-down model of guide vanes (GV) of a Francis turbine) and a transparent wall of the test section was studied. The experiments were carried out for different cavitating regimes on the cavitation number and two attack angles of 3° and 9°, with the gap size (tip clearance width) varied in the range from 0.4 to 0.8 mm. In order to determine the cavitation inception conditions and investigate the dynamics of the tip-leakage cavitation, a high-speed visualization was applied. A modified PIV/PTV technique with a diverging laser beam instead of a laser light sheet was used to measure the mean velocity distributions within the gap. It was shown that the cavitation pattern on the suction side of the GV model impacts the dynamics of the leakage flow in the gap but does not affect the sheet cavity formed close to the foil leading edge in the clearance as well as its size and dynamics. When the gap size is increased, the tip-leakage cavitation initiates at higher cavitation numbers or, in other words, conditions for the cavitation occurrence become more favorable.

Impact of the lithographic discontinuities on the karst conduit development - insights from modelling

NASA Astrophysics Data System (ADS)

Petrus, Karine; Szymczak, Piotr

2016-04-01

Karst formation is controlled by the processes of the fluid flow and reactant transport coupled to the chemical erosion of the limestone rock [1]. The coupling between these processes can lead to a number of different instabilities, resulting in the formation of dissolutional voids, caverns and conduits. Arguably the simplest systems of this kind are solution pipes, in which gravitationally driven water movement carves vertical conduits in limestone rocks. In the homogeneous rocks these conduits are often cylindrical, with almost a constant diameter along their length. However, in a stratified medium, the morphology of the pipes changes. For example, if a number of less porous layers is introduced in an otherwise homogeneous medium, then the pipes are observed to narrow as they cross the layers and then widen up to form bulbous caverns as they emerge from the layer [1]. In this communication, we investigate these effects more closely, considering different kind of lithographic discontinuities to be present in the system: the layers of increased/decreased porosity and/or permeability as well as the solubility which is different from the rest of the system. Using a Darcy-scale numerical model we analyze the effects these layers have on the shape and growth of solution pipes and compare the results on the piping morphologies observed in nature. Finally we comment on the possible relevance of these results to the cave-formation phenomena and the inception horizon concept [3]. References: 1.Howard A. D., The development of karst features, Bull. Natl. Spel. Soc. 25, 45-65 (1963) 2. Petrus, K. and Szymczak, P., Influence of layering on the formation and growth of solution pipes. Frontiers in Physics (submitted) 3.Filipponi , M., Jeannin, P. and Tacher, L., Evidence of inception horizons in karst conduit networks, Geomorphology, 106, 86-99 (2009)

Neural Network for Nanoscience Scanning Electron Microscope Image Recognition.

PubMed

Modarres, Mohammad Hadi; Aversa, Rossella; Cozzini, Stefano; Ciancio, Regina; Leto, Angelo; Brandino, Giuseppe Piero

2017-10-16

In this paper we applied transfer learning techniques for image recognition, automatic categorization, and labeling of nanoscience images obtained by scanning electron microscope (SEM). Roughly 20,000 SEM images were manually classified into 10 categories to form a labeled training set, which can be used as a reference set for future applications of deep learning enhanced algorithms in the nanoscience domain. The categories chosen spanned the range of 0-Dimensional (0D) objects such as particles, 1D nanowires and fibres, 2D films and coated surfaces, and 3D patterned surfaces such as pillars. The training set was used to retrain on the SEM dataset and to compare many convolutional neural network models (Inception-v3, Inception-v4, ResNet). We obtained compatible results by performing a feature extraction of the different models on the same dataset. We performed additional analysis of the classifier on a second test set to further investigate the results both on particular cases and from a statistical point of view. Our algorithm was able to successfully classify around 90% of a test dataset consisting of SEM images, while reduced accuracy was found in the case of images at the boundary between two categories or containing elements of multiple categories. In these cases, the image classification did not identify a predominant category with a high score. We used the statistical outcomes from testing to deploy a semi-automatic workflow able to classify and label images generated by the SEM. Finally, a separate training was performed to determine the volume fraction of coherently aligned nanowires in SEM images. The results were compared with what was obtained using the Local Gradient Orientation method. This example demonstrates the versatility and the potential of transfer learning to address specific tasks of interest in nanoscience applications.

Bypass Transition in Turbomachinery Flows: Turbulent Spots and the Calming Effect

DTIC Science & Technology

2010-10-04

still 0.9 Tera- Bytes. 2.4. Visualization of the turbulent spots The challenge in identifying the turbulent spots is two-fold. Firstly, the spots are spo ...the axis 22 (a) 180 200 220 240 260 280 300 320 340 360 380 400 0 1 2 3 4 5 6 7 8 9 10 Streamwise spot inception location (X) S po t I nc ep tio n fr...eq ue nc y (b) 200 220 240 260 280 300 320 340 360 380 400 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 Streamwise spot inception location (X) E m pi ric al

Investigation of nozzle flow and cavitation characteristics in a diesel injector.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Som, S.; Ramirez, A.; Aggarwal, S.

2010-04-01

Cavitation and turbulence inside a diesel injector play a critical role in primary spray breakup and development processes. The study of cavitation in realistic injectors is challenging, both theoretically and experimentally, since the associated two-phase flow field is turbulent and highly complex, characterized by large pressure gradients and small orifice geometries. We report herein a computational investigation of the internal nozzle flow and cavitation characteristics in a diesel injector. A mixture based model in FLUENT V6.2 software is employed for simulations. In addition, a new criterion for cavitation inception based on the total stress is implemented, and its effectiveness inmore » predicting cavitation is evaluated. Results indicate that under realistic diesel engine conditions, cavitation patterns inside the orifice are influenced by the new cavitation criterion. Simulations are validated using the available two-phase nozzle flow data and the rate of injection measurements at various injection pressures (800-1600 bar) from the present study. The computational model is then used to characterize the effects of important injector parameters on the internal nozzle flow and cavitation behavior, as well as on flow properties at the nozzle exit. The parameters include injection pressure, needle lift position, and fuel type. The propensity of cavitation for different on-fleet diesel fuels is compared with that for n-dodecane, a diesel fuel surrogate. Results indicate that the cavitation characteristics of n-dodecane are significantly different from those of the other three fuels investigated. The effect of needle movement on cavitation is investigated by performing simulations at different needle lift positions. Cavitation patterns are seen to shift dramatically as the needle lift position is changed during an injection event. The region of significant cavitation shifts from top of the orifice to bottom of the orifice as the needle position is changed from fully open (0.275 mm) to nearly closed (0.1 mm), and this behavior can be attributed to the effect of needle position on flow patterns upstream of the orifice. The results demonstrate the capability of the cavitation model to predict cavitating nozzle flows in realistic diesel injectors and provide boundary conditions, in terms of vapor fraction, velocity, and turbulence parameters at the nozzle exit, which can be coupled with the primary breakup simulation.« less

Topics in viscous potential flow of two-phase systems

NASA Astrophysics Data System (ADS)

Padrino Inciarte, Juan Carlos

Two-phase flows are ubiquitous, from natural and domestic environments to industrial settings. However, due to their complexity, modeling these fluid systems remains a challenge from both the perspective of fundamental questions on the dynamics of an individual, smooth interface, and the perspective of integral analyses, which involve averaging of the conservation laws over large domains, thereby missing local details of the flow. In this work, we consider a set of five problems concerning the linear and non-linear dynamics of an interface or free surface and the study of cavitation inception. Analyses are carried out by assuming the fluid motion to be irrotational, that is, with zero vorticity, and the fluids to be viscous, although results from rotational analyses are presented for the purpose of comparison. The problems considered here are the following: First, we analyze the non-linear deformation and break-up of a bubble or drop immersed in a uniaxial extensional flow of an incompressible viscous fluid. The method of viscous potential flow, in which the flow field is irrotational and viscosity enters through the balance of normal stresses at the interface, is used in the analysis. The governing equations are solved numerically to track the motion of the interface by coupling a boundary element method with a time-integration routine. When break-up occurs, the break-up time computed here is compared with results obtained elsewhere from numerical simulations of the Navier.Stokes equations, which thus keeps vorticity in the analysis, for several combinations of the relevant dimensionless parameters of the problem. For the bubble, for Weber numbers 3 ≤ We ≤ 6, predictions from viscous potential flow shows good agreement with the results from the Navier.Stokes equations for the bubble break-up time, whereas for larger We, the former underpredicts the results given by the latter. Including viscosity increases the break-up time with respect to the inviscid case. For the drop, as expected, increasing the viscous effects of the irrotational motion produces large, elongated drops that take longer to break up in comparison with results for inviscid fluids. In the second problem, we compute the force acting on a spherical bubble of variable radius moving within a liquid with an outer spherical boundary. Viscous potential flow and the dissipation method, which is another purely irrotational approach stemming from the mechanical energy equation, are both systematically implemented. This exposes the role of the choice of the outer boundary condition for the stress on the drag, an issue not explained in the literature known to us. By means of the well-known "cell-model" analysis, the results for the drag are then applied to the case of a swarm of rising bubbles having a certain void fraction. Computations from the dissipation method for the drag coefficient and rise velocity for a bubble swarm agree with numerical solutions; evaluation against experimental data for high Reynolds and low Weber numbers shows that all the models considered, including those given in the literature, overpredict the bubble swarm rise velocity. In the next two problems, we apply the analysis of viscous potential flow and the dissipation method to study the linear dynamics of waves of "small" amplitude acting either on a plane or on a spherical interface separating a liquid from a dynamically inactive fluid. It is shown that the viscous irrational theories exhibit the features of the wave dynamics by comparing with the exact solution. The range of parameters for which good agreement with the exact solution exists is presented. The general trend shows that for long waves the dissipation method results in the best approximation, whereas for short waves, even for very viscous liquids, viscous potential flow demonstrates better agreement. Finally, the problem of cavitation inception for the flow of a viscous liquid past a stationary sphere is studied by means of the theory of stress-induced cavitation. The flow field for a single phase needed in the analysis is found from three different methods, namely, the numerical solution of the Navier--Stokes equations, the irrotational motion of a viscous fluid, and, in the limit of no inertia, the Stokes flow formulation. The new predictions are then compared with those obtained from the classical pressure criterion. The main finding is that at a fixed cavitation number more viscous liquids are at greater risk to cavitation.

Economic evaluation of lupus nephritis in the Systemic Lupus International Collaborating Clinics inception cohort using a multistate model approach.

PubMed

Barber, Megan R W; Hanly, John G; Su, Li; Urowitz, Murray B; Pierre, Yvan St; Romero-Diaz, Juanita; Gordon, Caroline; Bae, Sang-Cheol; Bernatsky, Sasha; Wallace, Daniel J; Isenberg, David A; Rahman, Anisur; Ginzler, Ellen M; Petri, Michelle; Bruce, Ian N; Fortin, Paul R; Gladman, Dafna D; Sanchez-Guerrero, Jorge; Ramsey-Goldman, Rosalind; Khamashta, Munther A; Aranow, Cynthia; Mackay, Meggan; Alarcón, Graciela S; Manzi, Susan; Nived, Ola; Jönsen, Andreas; Zoma, Asad A; van Vollenhoven, Ronald F; Ramos-Casals, Manuel; Ruiz-Irastorza, Guillermo; Sam Lim, S; Kalunian, Kenneth C; Inanc, Murat; Kamen, Diane L; Peschken, Christine A; Jacobsen, Soren; Askanase, Anca; Theriault, Chris; Farewell, Vernon; Clarke, Ann E

2017-11-28

Little is known about the long-term costs of lupus nephritis (LN). These were compared between patients with and without LN based on multistate modelling. Patients from 32 centres in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis and provided annual data on renal function, hospitalizations, medications, dialysis, and selected procedures. LN was diagnosed by renal biopsy or the American College of Rheumatology classification criteria. Renal function was assessed annually using estimated glomerular filtration rate (eGFR) or proteinuria (ePrU). A multistate model was used to predict 10-year cumulative costs by multiplying annual costs associated with each renal state by the expected state duration. 1,545 patients participated, 89.3% female, mean age at diagnosis 35.2 years (SD 13.4), 49.0% Caucasian, and mean follow up 6.3 years (SD 3.3). LN developed in 39.4% by the end of follow up. Ten-year cumulative costs were greater in those with LN and an eGFR < 30 ml/min ($310 579 2015 Canadian dollars versus $19 987 if no LN and eGFR > 60 ml/min) or with LN and ePrU > 3 g/d ($84 040 versus $20 499 if no LN and ePrU < 0.25 g/d). Patients with eGFR < 30 ml/min incurred 10-year costs 15-fold higher than those with normal eGFR. By estimating the expected duration in each renal state and incorporating associated annual costs, disease severity at presentation can be used to anticipate future healthcare costs. This is critical knowledge for cost-effectiveness evaluations of novel therapies. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Systematic Review and Meta-analysis: Placebo Rates in Induction and Maintenance Trials of Ulcerative Colitis.

PubMed

Jairath, Vipul; Zou, Guangyong; Parker, Claire E; Macdonald, John K; Mosli, Mahmoud H; Khanna, Reena; Shackelton, Lisa M; Vandervoort, Margaret K; AlAmeel, Turki; Al Beshir, Mohammad; AlMadi, Majid; Al-Taweel, Talal; Atkinson, Nathan S S; Biswas, Sujata; Chapman, Thomas P; Dulai, Parambir S; Glaire, Mark A; Hoekman, Daniel; Koutsoumpas, Andreas; Minas, Elizabeth; Samaan, Mark A; Travis, Simon; D'Haens, Geert; Levesque, Barrett G; Sandborn, William J; Feagan, Brian G

2016-05-01

Minimisation of the placebo responses in randomised controlled trials [RCTs] is essential for efficient evaluation of new interventions. Placebo rates have been high in ulcerative colitis [UC] clinical trials, and factors influencing this are poorly understood. We quantify placebo response and remission rates in UC RCTs and identify trial design factors influencing them. MEDLINE, EMBASE, and the Cochrane Library were searched from inception through April 2014 for placebo-controlled trials in adult patients with UC of a biological agent, corticosteroid, immunosuppressant, or aminosalicylate. Data were independently doubly extracted. Quality was assessed using the Cochrane risk of bias tool. In all, 51 trials [48 induction and 10 maintenance phases] were identified. Placebo response and remission rates were pooled according to random-effects models, and mixed-effects meta-regression models were used to evaluate effects of study-level characteristics on these rates. Pooled estimates of placebo remission and response rates for induction trials were 10% (95% confidence interval [CI] 7-13%) and 33% [95% CI 29-37%], respectively. Corresponding values for maintenance trials were 19% [95% CI 11-30%] and 22% [95% CI 17-28%]. Trials enrolling patients with more active disease confirmed by endoscopy [endoscopy subscore ≥ 2] were associated with lower placebo rates. Conversely, placebo rates increased with increasing trial duration and number of study visits. Objective assessment of greater disease activity at trial entry by endoscopy lowered placebo rates, whereas increasing trial duration and more interactions with healthcare providers increased placebo rates. These findings have important implications for design and conduct of clinical trials. Copyright © 2016 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Restructuring VA ambulatory care and medical education: the PACE model of primary care.

PubMed

Cope, D W; Sherman, S; Robbins, A S

1996-07-01

The Veterans Health Administration (VHA) Western Region and associated medical schools formulated a set of recommendations for an improved ambulatory health care delivery system during a 1988 strategic planning conference. As a result, the Department of Veterans Affairs (VA) Medical Center in Sepulveda, California, initiated the Pilot (now Primary) Ambulatory Care and Education (PACE) program in 1990 to implement and evaluate a model program. The PACE program represents a significant departure from traditional VA and non-VA academic medical center care, shifting the focus of care from the inpatient to the outpatient setting. From its inception, the PACE program has used an interdisciplinary team approach with three independent global care firms. Each firm is interdisciplinary in composition, with a matrix management structure that expands role function and empowers team members. Emphasis is on managed primary care, stressing a biopsychosocial approach and cost-effective comprehensive care emphasizing prevention and health maintenance. Information management is provided through a network of personal computers that serve as a front end to the VHA Decentralized Hospital Computer Program (DHCP) mainframe. In addition to providing comprehensive and cost-effective care, the PACE program educates trainees in all health care disciplines, conducts research, and disseminates information about important procedures and outcomes. Undergraduate and graduate trainees from 11 health care disciplines rotate through the PACE program to learn an integrated approach to managed ambulatory care delivery. All trainees are involved in a problem-based approach to learning that emphasizes shared training experiences among health care disciplines. This paper describes the transitional phases of the PACE program (strategic planning, reorganization, and quality improvement) that are relevant for other institutions that are shifting to training programs emphasizing primary and ambulatory care.

Recommendations and Ongoing Efforts within the NASA Data Quality Working Group

NASA Astrophysics Data System (ADS)

Moroni, D. F.; Ramapriyan, H.; Bagwell, R.; Downs, R. R.

2015-12-01

Since its inception in March 2014, the NASA Data Quality Working Group (DQWG) has procured a set of 12 high level recommendations which had been sifted from and aggregated from a prioritized subset of nearly 100 unique recommendations spanning four unique data quality management phases and distributed between two actionable categories. The four data quality management phases as identified by the DQWG are: 1. Capturing (i.e., deriving, collecting and organizing the information), 2. Describing (i.e., documenting and procuring the information for public consumption), 3. Facilitating Discovery (i.e., publishing and providing access to the information), and 4. Enabling Use (i.e., enhancing the utility of the information). Mapping each of our recommendations to one or more of the above management phases is intended to enable improved assessment of cost, feasibility, and relevancy to the entities responsible for implementing such recommendations. The DQWG further defined two distinct actionable categories: 1) Data Systems and 2) Science. The purpose of these actionable categories is to define specifically who is responsible for the implementation and adherence toward these recommendations; we refer to the responsible entities as the "actionees". Here we will summarize each of the high level recommendations along with their corresponding management phases and actionees. We will present what has recently been identified as our set of "low-hanging fruit" recommendations, which are intended for near-term implementation. Finally, we will present the status and motivation for continuing and future planned activities, which include but are not limited to: engaging inter-agency and international communities, more direct feedback from Earth observation missions, and mapping of "low-hanging fruit" recommendations to existing solutions.

Occluder closing behavior: a key factor in mechanical heart valve cavitation.

PubMed

Wu, Z J; Wang, Y; Hwang, N H

1994-04-01

A laser sweeping technique developed in this laboratory was found to be capable of monitoring the leaflet closing motion with microsecond precision. The leaflet closing velocity was measured inside the last three degrees before impact. Mechanical heart valve (MHV) leaflets were observed to close with a three-phase motion; the approaching phase, the decelerating phase, and the rebound phase, all of which take place within one to two milliseconds. The leaflet closing behavior depends mainly on the leaflet design and the hinge mechanism. Bileaflet and monoleaflet types of mechanical heart valves were tested in the mitral position in a physiologic mock circulatory flow loop, which incorporated a computer-controlled magnetic drive and an adjustable afterload system. The test loop was tuned to produce physiologic ventricular and aortic pressure wave forms at 70-120 beats/min, with the maximum ventricular dp/dt varying between 1500-5600 mmHg/sec. The experiments were conducted by controlling the cardiac output at a constant level between 2.0-9.0 liters/min. The measured time-displacement curve of each tested MHV leaflet and its geometry were taken as the input for computation of the squeeze flow field in the narrow gap space between the approaching leaflet and the valve housing. The results indicated rapid build-up of both the pressure and velocity in the gap field within microsecs before the impact. The pressure build-up in the gap space is apparently responsible for the leaflet deceleration before the impact. When the concurrent water hammer pressure reduction at closure was combined with the high energy squeeze jet ejected from the gap space, there were strong indications of the environment which favors micro cavitation inceptions in certain types of MHV.

A Computational Investigation of Sooting Limits of Spherical Diffusion Flames

NASA Technical Reports Server (NTRS)

Lecoustre, V. R.; Chao, B. H.; Sunderland, P. B.; Urban, D. L.; Stocker, D. P.; Axelbaum, R. L.

2007-01-01

Limiting conditions for soot particle inception in spherical diffusion flames were investigated numerically. The flames were modeled using a one-dimensional, time accurate diffusion flame code with detailed chemistry and transport and an optically thick radiation model. Seventeen normal and inverse flames were considered, covering a wide range of stoichiometric mixture fraction, adiabatic flame temperature, and residence time. These flames were previously observed to reach their sooting limits after 2 s of microgravity. Sooting-limit diffusion flames with residence times longer than 200 ms were found to have temperatures near 1190 K where C/O = 0.6, whereas flames with shorter residence times required increased temperatures. Acetylene was found to be a reasonable surrogate for soot precursor species in these flames, having peak mole fractions of about 0.01.

Ejection mechanisms in the sublayer of a turbulent channel

NASA Technical Reports Server (NTRS)

Jimenez, J.; Moin, P.; Moser, R. D.; Keefe, L. R.

1987-01-01

A possible model for the inception of vorticity ejections in the viscous sublayer of a turbulent rectangular channel is presented. It was shown that this part of the flow is dominated by protruding strong shear layers of z-vorticity, and it was proposed as a mechanism for their maintenance and reproduction which is essentially equivalent to that responsible for the instability of 2-D Tollmien-Schlichting waves. The efforts to isolate computationally a single structure for its study have failed up to now, since it appears that single structures decay in the absence of external forcing, but a convenient computation model was identified in the form of a long and narrow periodic computational box containing at each moment only a few structures. Further work in the identification of better reduced systems is in progress.

Effects of C/O Ratio and Temperature on Sooting Limits of Spherical Diffusion Flames

NASA Technical Reports Server (NTRS)

Lecoustre, V. R.; Sunderland, P. B.; Chao, B. H.; Urban, D. L.; Stocker, D. P.; Axelbaum, R. L.

2008-01-01

Limiting conditions for soot particle inception in spherical diffusion flames were investigated numerically. The flames were modeled using a one-dimensional, time accurate diffusion flame code with detailed chemistry and transport and an optically thick radiation model. Seventeen normal and inverse flames were considered, covering a wide range of stoichiometric mixture fraction, adiabatic flame temperature, residence time and scalar dissipation rate. These flames were previously observed to reach their sooting limits after 2 s of microgravity. Sooting-limit diffusion flames with scalar dissipation rate lower than 2/s were found to have temperatures near 1400 K where C/O = 0.51, whereas flames with greater scalar dissipation rate required increased temperatures. This finding was valid across a broad range of fuel and oxidizer compositions and convection directions.

High fidelity simulation of non-synchronous vibration for aircraft engine fan/compressor

NASA Astrophysics Data System (ADS)

Im, Hong-Sik

The objectives of this research are to develop a high fidelity simulation methodology for turbomachinery aeromechanical problems and to investigate the mechanism of non-synchronous vibration (NSV) of an aircraft engine axial compressor. A fully conservative rotor/stator sliding technique is developed to accurately capture the unsteadiness and interaction between adjacent blade rows. Phase lag boundary conditions (BC) based on the time shift (direct store) method and the Fourier series phase lag BC are implemented to take into account the effect of phase difference for a sector of annulus simulation. To resolve the nonlinear interaction between flow and vibrating blade structure, a fully coupled fluid-structure interaction (FSI) procedure that solves the structural modal equations and time accurate Navier-Stokes equations simultaneously is adopted. An advanced mesh deformation method that generates the blade tip block mesh moving with the blade displacement is developed to ensure the mesh quality. An efficient and low diffusion E-CUSP (LDE) scheme as a Riemann solver designed to minimize numerical dissipation is used with an improved hybrid RANS/LES turbulence strategy, delayed detached eddy simulation (DDES). High order accuracy (3rd and 5th order) weighted essentially non-oscillatory (WENO) schemes for inviscid flux and a conservative 2nd and 4th order viscous flux differencing are employed. Extensive validations are conducted to demonstrate high accuracy and robustness of the high fidelity FSI simulation methodology. The validated cases include: (1) DDES of NACA 0012 airfoil at high angle of attack with massive separation. The DDES accurately predicts the drag whereas the URANS model significantly over predicts the drag. (2) The AGARD Wing 445.6 flutter boundary is accurately predicted including the point at supersonic incoming flow. (3) NASA Rotor 67 validation for steady state speed line and radial profiles at peak efficiency point and near stall point. The calculated results agree excellently with the experiment. (4) NASA Stage 35 speed line and radial profiles to validate the steady state mixing plane BC for multistage computation. Excellent agreement is obtained between the computation and experiment. (5) NASA Rotor 67 full annulus and single passage FSI simulation at near peak condition to validate phase lag BC. The time shifted phase lag BC accurately predicts blade vibration responses that agrees better with the full annulus FSI simulation. The DDES methodology is used to investigate the stall inception of NASA Rotor 67. The stall process begins with spike inception and develops to full stall. The whole process is simulated with full annulus of the rotor. The fully coupled FSI is then used to simulate the stall flutter of NASA Rotor 67. The multistage simulations of a GE aircraft engine high pressure compressor (HPC) reveal for the first time that the travelling tornado vortex formed on the rotor blade tip region is the root cause for the NSV of the compressor. The rotor blades under NSV have large torsional vibration due to the tornado vortex propagation in the opposite to the rotor rotation. The tornado vortex frequency passing the suction surface of each blade in the tip region agrees with the NSV frequency. The predicted NSV frequency based on URANS model with rigid blades agrees very well with the experimental measurement with only 3.3% under-predicted. The NSV prediction using FSI with vibrating blades also obtain the same frequency as the rigid blades. This is because that the NSV is primarily caused by the flow vortex instability and the no resonance occurs. The blade structures respond passively and the small amplitudes of the blade vibration do not have significant effect on the flow. The predicted frequency using DDES with rigid blades is more deviated from the experiment and is 14.7% lower. The reason is that the DDES tends to predict the rotor stall earlier than the URANS and the NSV can be achieved only at higher mass flow rate, which generates a lower frequency. The possible reason for the DDES to predict the rotor stall early may be because DDES is more sensitive to wave reflection and a non-reflective boundary condition may be necessary. Overall, the high fidelity FSI methodology developed in this thesis for aircraft engine fan/compressor aeromechanics simulation is demonstrated to be very successful and has advanced the forefront of the state of the art. Future work to continue to improve the accuracy and efficiency is discussed at the end of the thesis.

Can ethnography save the life of medical ethics?

PubMed

Hoffmaster, B

1992-12-01

Since its inception contemporary medical ethics has been regarded by many of its practitioners as 'applied ethics', that is, the application of philosophical theories to the moral problems that arise in health care. This 'applied ethics' model of medical ethics is, however, beset with internal and external difficulties. The internal difficulties point out that the model is intrinsically flawed. The external difficulties arise because the model does not fit work in the field. Indeed, the strengths of that work are its highly nuanced, particularized analyses of cases and issues and its appreciation of the circumstances and contexts that generate and structure these cases and issues. A shift away from a theory-driven 'applied ethics' to a more situational, contextual approach to medical ethics opens the way for ethnographic studies of moral problems in health care as well as a conception of moral theory that is more responsive to the empirical dimensions of those problems.

A transfer learning approach for classification of clinical significant prostate cancers from mpMRI scans

NASA Astrophysics Data System (ADS)

Chen, Quan; Xu, Xiang; Hu, Shiliang; Li, Xiao; Zou, Qing; Li, Yunpeng

2017-03-01

Deep learning has shown a great potential in computer aided diagnosis. However, in many applications, large dataset is not available. This makes the training of a sophisticated deep learning neural network (DNN) difficult. In this study, we demonstrated that with transfer learning, we can quickly retrain start-of-the-art DNN models with limited data provided by the prostateX challenge. The training data consists of 330 lesions, only 78 were clinical significant. Efforts were made to balance the data during training. We used ImageNet pre-trained inceptionV3 and Vgg-16 model and obtained AUC of 0.81 and 0.83 respectively on the prostateX test data, good for a 4th place finish. We noticed that models trained for different prostate zone has different sensitivity. Applying scaling factors before merging the result improves the AUC for the final result.

Nurses' perceptions of the challenges related to the Omanization policy.

PubMed

Al-Riyami, M; Fischer, I; Lopez, V

2015-12-01

Human resource development has become a major concern in Oman since the inception of the 'Omanization' policy in 1988. The main goal of this policy was to replace the expatriate nursing workforce with similarly qualified local nurses to develop a sustainable workforce and achieve self-reliance. The aim of this study is to explore the nurses' perceptions of Omanization policy. A qualitative research design was used and 16 Omani registered nurses and 26 student nurses were interviewed in depth. Transcribed data were analysed using content analysis. Two main themes emerged from the data: 'Challenges of sustaining the local nursing workforce' and 'Challenges of educational preparation for local nurses'. The participants agreed that Omanization benefited national development, social stability and ensuring local workforce. The challenges faced were cultural and work life balance, preparation of nurses and pace of replacement. The participants were concerned that the pace of replacement could leave behind a marked experience gap. A slow-phased approach to Omanization of the nursing workforce was recommended by the participants. Results obtained from this study reflect the perceptions and voices of student nurses and registered nurses only from the Institute of Nursing and Oman Ministry of Health. A policy of this magnitude requires gradual establishment. The upgrading of the nursing education to degree level, continuous professional development, mentoring and role modeling of expert nurses should be established to prepare local nurses for the localization of the nursing workforce. © 2015 International Council of Nurses.

How Human Niche Construction is tied to the landscape perspective of domesticated landscapes and how this may help the discussion about the offset of the Anthropocene

NASA Astrophysics Data System (ADS)

Kluiving, Sjoerd; Hamel, Arthur

2016-04-01

This research is based on a review of published examples of geoarchaeological and landscape archaeological research throughout Europe. Through environmental reconstruction we relatively date the starting points where humans a) are altering their own selective environment as an inceptive change, b) respond to a (deteriorated) selective environment in a counteractive change. It is stated that geoarchaeology and landscape archaeology make a valuable contribution to NCT studies in considering landscape gradients as focal lines. NCT phase transitions from inceptive to counteractive changes are proposed as useful alternative in the debate about the onset of the Anthropocene. While searching for a relevant approach to define this period where humans are driving the Earth, we discuss the pitfalls of the dialectic Nature/Culture and social/environmental divides and finally we prefer to approach the issue from the complex system perspective which does not opposes 'humans' with 'the rest'. In complex systems, such as Earth system, linear cause consequence relations do not exist. Therefore the response of the system is not always related in time, space or proportions with the causes. On this basis, we present an alternative definition of the Anthropocene based on the causes of the changes instead of their effects. These causes are to be found in the change in human behaviour. The Niche Construction Theory conciliates the causes and the complex system approach previous remarks: that the effects are not easily correlated with the causes of changes. This is the point of view adopted by Zeder and Smith (2013) who argue that the onset of the Anthropocene is the start of Neolithic revolution, matching the lower boundary of the Holocene. Zeder M. A. and Smith B.D. (2013). The onset of the Anthropocene. Anthropocene, 4:8-13.

Effect of double air injection on performance characteristics of centrifugal compressor

NASA Astrophysics Data System (ADS)

Hirano, Toshiyuki; Ogawa, Tatsuya; Yasui, Ryutaro; Tsujita, Hoshio

2017-02-01

In the operation of a centrifugal compressor of turbocharger, instability phenomena such as rotating stall and surge are induced at a lower flow rate close to the maximum pressure ratio. In this study, the compressed air at the exit of centrifugal compressor was re-circulated and injected to the impeller inlet by using two injection nozzles in order to suppress the surge phenomenon. The most effective circumferential position was examined to reduce the flow rate at the surge inception. Moreover, the influences of the injection on the fluctuating property of the flow field before and after the surge inception were investigated by examining the frequency of static pressure fluctuation on the wall surface and visualizing the compressor wall surface by oil-film visualization technique.

Analysis of a space emergency ammonia dump using the FLOW-NET two-phase flow program

NASA Technical Reports Server (NTRS)

Navickas, J.; Rivard, W. C.

1992-01-01

Venting of cryogenic and non-cryogenic fluids to a vacuum or a very low pressure will take place in many space-based systems that are currently being designed. This may cause liquid freezing either internally within the flow circuit or on external spacecraft surfaces. Typical ammonia flow circuits were investigated to determine the effect of the geometric configuration and initial temperature, pressure, and void fraction on the freezing characteristics of the system. The analysis was conducted also to investigate the ranges of applicability of the FLOW-NET program. It was shown that a typical system can be vented to very low liquid fractions before freezing occurs. However, very small restrictions in the flow circuit can hasten the inception of freezing. The FLOW-NET program provided solutions over broad ranges of system conditions, such as venting of an ammonia tank, initially completely filled with liquid, through a series of contracting and expanding line cross sections to near-vacuum conditions.

Enacting a Vision for a Master's Entry Clinical Nurse Leader Program: Rethinking Nursing Education.

PubMed

Hicks, Frank D; Rosenberg, Lisa

2016-01-01

The need to educate nurses at the graduate level and provide them with a different skill set that broadens their view of health and nursing is clearly articulated by the American Association of Colleges of Nursing. Consequently, the role of the clinical nurse leader (CNL) was born. Responding to the need for providing a highly educated and credentialed professional at the bedside, Rush University College of Nursing made the bold move to phase out baccalaureate education and enact a prelicensure, master's entry CNL program. Although there is a clear need for this type of graduate, there is little in the literature to provide guidance to institutions that wish to develop this type of program. This paper describes the factors that came into play in making that decision, the process of curriculum development and implementation, the challenges encountered in implementing this type of program, and the outcomes that the program has evidenced since its inception. Copyright © 2016 Elsevier Inc. All rights reserved.

Modelling of mineral dust for interglacial and glacial climate conditions with a focus on Antarctica

DOE PAGES

Sudarchikova, Natalia; Mikolajewicz, Uwe; Timmreck, C.; ...

2015-05-19

The mineral dust cycle responds to climate variations and plays an important role in the climate system by affecting the radiative balance of the atmosphere and modifying biogeochemistry. Polar ice cores provide unique information about deposition of aeolian dust particles transported over long distances. These cores are a palaeoclimate proxy archive of climate variability thousands of years ago. The current study is a first attempt to simulate past interglacial dust cycles with a global aerosol–climate model ECHAM5-HAM. The results are used to explain the dust deposition changes in Antarctica in terms of quantitative contribution of different processes, such as emission,more » atmospheric transport and precipitation, which will help to interpret palaeodata from Antarctic ice cores. The investigated periods include four interglacial time slices: the pre-industrial control (CTRL), mid-Holocene (6000 yr BP; hereafter referred to as \\"6 kyr\\"), last glacial inception (115 000 yr BP; hereafter \\"115 kyr\\") and Eemian (126 000 yr BP; hereafter \\"126 kyr\\"). One glacial time interval, the Last Glacial Maximum (LGM) (21 000 yr BP; hereafter \\"21 kyr\\"), was simulated as well to be a reference test for the model. Results suggest an increase in mineral dust deposition globally, and in Antarctica, in the past interglacial periods relative to the pre-industrial CTRL simulation. Approximately two-thirds of the increase in the mid-Holocene and Eemian is attributed to enhanced Southern Hemisphere dust emissions. Slightly strengthened transport efficiency causes the remaining one-third of the increase in dust deposition. The moderate change in dust deposition in Antarctica in the last glacial inception period is caused by the slightly stronger poleward atmospheric transport efficiency compared to the pre-industrial. Maximum dust deposition in Antarctica was simulated for the glacial period. LGM dust deposition in Antarctica is substantially increased due to 2.6 times higher Southern Hemisphere dust emissions, 2 times stronger atmospheric transport towards Antarctica, and 30% weaker precipitation over the Southern Ocean. The model is able to reproduce the order of magnitude of dust deposition globally and in Antarctica for the pre-industrial and LGM climates.« less

Scale effects on propeller cavitating hydrodynamic and hydroacoustic performances with non-uniform inflow

NASA Astrophysics Data System (ADS)

Yang, Qiongfang; Wang, Yongsheng; Zhang, Zhihong

2013-03-01

Considering the lack of theoretical models and ingredients necessary to explain the scaling of the results of propeller cavitation inception and cavitating hydroacoustics from model tests to full scale currently, and the insufficient reflection of the nuclei effects on cavitation in the numerical methods, the cavitating hydrodynamics and cavitation low frequency noise spectrum of three geometrically similar 7-bladed highly skewed propellers with non-uniform inflow are addressed. In this process, a numerical bridge from the multiphase viscous simulation of propeller cavitation hydrodynamics to its hydro-acoustics is built, and the scale effects on performances and the applicability of exist scaling law are analyzed. The effects of non-condensable gas(NCG) on cavitation inception are involved explicitly in the improved Sauer's cavitation model, and the cavity volume acceleration related to its characteristic length is used to produce the noise spectrum. Results show that, with the same cavitation number, the cavity extension on propeller blades increases with diameter associated with an earlier shift of the beginning point of thrust decline induced by cavitation, while the three decline slopes of thrust breakdown curves are found to be nearly the same. The power of the scaling law based on local Reynolds number around 0.9 R section is determined as 0.11. As for the smallest propeller, the predominant tonal noise is located at blade passing frequency(BPF), whereas 2BPF for the middle and both 2BPF and 3BPF for the largest, which shows the cavitating line spectrum is fully related to the interaction between non-uniform inflow and fluctuated cavity volume. The predicted spectrum level exceedance from the middle to the large propeller is 6.65 dB at BPF and 5.94 dB at 2BPF. Since it just differs less than 2 dB to the increment obtained by empirical scaling law, it is inferred that the scale effects on them are acceptable with a sufficient model scale, and so do the scaling law. The numerical implementation of cavitating hydrodynamics and hydro-acoustics prediction of propeller in big scale in wake has been completed.

Prediction of complicated disease course for children newly diagnosed with Crohn’s disease: a multicentre inception cohort study

PubMed Central

Kugathasan, Subra; Denson, Lee A; Walters, Thomas D; Kim, Mi-Ok; Marigorta, Urko M; Schirmer, Melanie; Mondal, Kajari; Liu, Chunyan; Griffiths, Anne; Noe, Joshua D; Crandall, Wallace V; Snapper, Scott; Rabizadeh, Shervin; Rosh, Joel R; Shapiro, Jason M; Guthery, Stephen; Mack, David R; Kellermayer, Richard; Kappelman, Michael D; Steiner, Steven; Moulton, Dedrick E; Keljo, David; Cohen, Stanley; Oliva-Hemker, Maria; Heyman, Melvin B; Otley, Anthony R; Baker, Susan S; Evans, Jonathan S; Kirschner, Barbara S; Patel, Ashish S; Ziring, David; Trapnell, Bruce C; Sylvester, Francisco A; Stephens, Michael C; Baldassano, Robert N; Markowitz, James F; Cho, Judy; Xavier, Ramnik J; Huttenhower, Curtis; Aronow, Bruce J; Gibson, Greg; Hyams, Jeffrey S; Dubinsky, Marla C

2017-01-01

Summary Background Stricturing and penetrating complications account for substantial morbidity and health-care costs in paediatric and adult onset Crohn’s disease. Validated models to predict risk for complications are not available, and the effect of treatment on risk is unknown. Methods We did a prospective inception cohort study of paediatric patients with newly diagnosed Crohn’s disease at 28 sites in the USA and Canada. Genotypes, antimicrobial serologies, ileal gene expression, and ileal, rectal, and faecal microbiota were assessed. A competing-risk model for disease complications was derived and validated in independent groups. Propensity-score matching tested the effect of anti-tumour necrosis factor α (TNFα) therapy exposure within 90 days of diagnosis on complication risk. Findings Between Nov 1, 2008, and June 30, 2012, we enrolled 913 patients, 78 (9%) of whom experienced Crohn’s disease complications. The validated competing-risk model included age, race, disease location, and antimicrobial serologies and provided a sensitivity of 66% (95% CI 51–82) and specificity of 63% (55–71), with a negative predictive value of 95% (94–97). Patients who received early anti-TNFα therapy were less likely to have penetrating complications (hazard ratio [HR] 0·30, 95% CI 0·10–0·89; p=0·0296) but not stricturing complication (1·13, 0·51–2·51; 0·76) than were those who did not receive early anti-TNFα therapy. Ruminococcus was implicated in stricturing complications and Veillonella in penetrating complications. Ileal genes controlling extracellular matrix production were upregulated at diagnosis, and this gene signature was associated with stricturing in the risk model (HR 1·70, 95% CI 1·12–2·57; p=0·0120). When this gene signature was included, the model’s specificity improved to 71%. Interpretation Our findings support the usefulness of risk stratification of paediatric patients with Crohn’s disease at diagnosis, and selection of anti-TNFα therapy. Funding Crohn’s and Colitis Foundation of America, Cincinnati Children’s Hospital Research Foundation Digestive Health Center. PMID:28259484

Transient Droplet Behavior and Droplet Breakup during Bulk and Confined Shear Flow in Blends with One Viscoelastic Component: Experiments, Modelling and Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cardinaels, Ruth; Verhulst, Kristof; Moldenaers, Paula

2008-07-07

The transient droplet deformation and droplet orientation after inception of shear, the shape relaxation after cessation of shear and droplet breakup during shear, are microscopically studied, both under bulk and confined conditions. The studied blends contain one viscoelastic Boger fluid phase. A counter rotating setup, based on a Paar Physica MCR300, is used for the droplet visualisation. For bulk shear flow, it is shown that the droplet deformation during startup of shear flow and the shape relaxation after cessation of shear flow are hardly influenced by droplet viscoelasticity, even at moderate to high capillary and Deborah numbers. The effects ofmore » droplet viscoelasticity only become visible close to the critical conditions and a novel break-up mechanism is observed. Matrix viscoelasticity has a more pronounced effect, causing overshoots in the deformation and significantly inhibiting relaxation. However, different applied capillary numbers prior to cessation of shear flow, with the Deborah number fixed, still result in a single master curve for shape retraction, as in fully Newtonian systems. The long tail in the droplet relaxation can be qualitatively described with a phenomenological model for droplet deformation, when using a 5-mode Giesekus model for the fluid rheology. It is found that the shear flow history significantly affects the droplet shape evolution and the breakup process in blends with one viscoelastic component. Confining a droplet between two plates accelerates the droplet deformation kinetics, similar to fully Newtonian systems. However, the increased droplet deformation, due to wall effects, causes the steady state to be reached at a later instant in time. Droplet relaxation is less sensitive to confinement, leading to slower relaxation kinetics only for highly confined droplets. For the blend with a viscoelastic droplet, a non-monotonous trend is found for the critical capillary number as a function of the confinement ratio. Finally, experimental data are compared with 3D simulations, performed with a volume-of-fluid algorithm.« less

Estimation of mass of black hole candidate H1743-322 using spectral and timing analysis of 2010 and 2011 outbursts with TCAF and POS models

NASA Astrophysics Data System (ADS)

Molla, Aslam Ali; Debnath, Dipak; Chakrabarti, Sandip Kumar; Mondal, Santanu; Jana, Arghajit; Chatterjee, Debjit

2016-07-01

The black hole X-ray binary H1743-322 has been observed almost during every X-ray mission since the inception of X-ray astronomy. Like other black hole candidates H1743-322 is highly variable. Using a self consistent accretion flow model (TCAF), we study spectral evolution during its 2010 & 2011 outbursts by keeping model normalization fixed to a value (14.5). As model normalization depends only on mass, distance and inclination angle of the black hole so, it should be a constant. This constant allows us to calculate mass of the black hole if we keep it frozen. The only uncertainty in mass and normalization measurements comes from the uncertainty of distance and inclination angle. Here we present spectral analysis of H1743-322 during 2010 and 2011 outburst and conclude that the mass of the black hole is within a range of 9 - 13 M_Sun.

A Historical Overview of Aeroelasticity Branch and Transonic Dynamics Tunnel Contributions to Rotorcraft Technology and Development

NASA Technical Reports Server (NTRS)

Yeager, William T., Jr.; Kvaternik, Raymond G.

2001-01-01

A historical account of the contributions of the Aeroelasticity Branch (AB) and the Langley Transonic Dynamics Tunnel (TDT) to rotorcraft technology and development since the tunnel's inception in 1960 is presented. The paper begins with a summary of the major characteristics of the TDT and a description of the unique capability offered by the TDT for testing aeroelastic models by virtue of its heavy gas test medium. This is followed by some remarks on the role played by scale models in the design and development of rotorcraft vehicles and a review of the basic scaling relationships important for designing and building dynamic aeroelastic models of rotorcraft vehicles for testing in the TDT. Chronological accounts of helicopter and tiltrotor research conducted in AB/TDT are then described in separate sections. Both experimental and analytical studies are reported and include a description of the various physical and mathematical models employed, the specific objectives of the investigations, and illustrative experimental and analytical results.

Research data management in academic institutions: A scoping review

PubMed Central

Ayala, A. Patricia; Dearborn, Dylanne; Kenny, Tim; Lightfoot, David; Reka, Roger; Thuna, Mindy; Trimble, Leanne

2017-01-01

Objective The purpose of this study is to describe the volume, topics, and methodological nature of the existing research literature on research data management in academic institutions. Materials and methods We conducted a scoping review by searching forty literature databases encompassing a broad range of disciplines from inception to April 2016. We included all study types and data extracted on study design, discipline, data collection tools, and phase of the research data lifecycle. Results We included 301 articles plus 10 companion reports after screening 13,002 titles and abstracts and 654 full-text articles. Most articles (85%) were published from 2010 onwards and conducted within the sciences (86%). More than three-quarters of the articles (78%) reported methods that included interviews, cross-sectional, or case studies. Most articles (68%) included the Giving Access to Data phase of the UK Data Archive Research Data Lifecycle that examines activities such as sharing data. When studies were grouped into five dominant groupings (Stakeholder, Data, Library, Tool/Device, and Publication), data quality emerged as an integral element. Conclusion Most studies relied on self-reports (interviews, surveys) or accounts from an observer (case studies) and we found few studies that collected empirical evidence on activities amongst data producers, particularly those examining the impact of research data management interventions. As well, fewer studies examined research data management at the early phases of research projects. The quality of all research outputs needs attention, from the application of best practices in research data management studies, to data producers depositing data in repositories for long-term use. PMID:28542450

Use of conservative and surgical foot care in an inception cohort of patients with rheumatoid arthritis.

PubMed

Backhouse, Michael R; Keenan, Anne-Maree; Hensor, Elizabeth M A; Young, Adam; James, David; Dixey, Josh; Williams, Peter; Prouse, Peter; Gough, Andrew; Helliwell, Philip S; Redmond, Anthony C

2011-09-01

To describe conservative and surgical foot care in patients with RA in England and explore factors that predict the type of foot care received. Use of podiatry and type of foot surgery were outcomes recorded in an inception cohort involving nine rheumatology centres that recruited patients with RA between 1986 and 1998 across England. Associations between patient-specific factors and service use were identified using univariate logistic regression analyses. The independence of these associations was then verified through multiple binary logistic regression modelling. Data were collected on 1237 patients with RA [66.9% females, mean (s.d.) age at disease onset = 54.36 (14.18) years, median DAS = 4.09 (1st quartile = 3.04, 3rd quartile = 5.26), median HAQ = 1 (0.50, 1.63)]. Interventions involving the feet in the cohort were low with only 364 (30%) out of 1218 receiving podiatry and 47 (4%) out of 1237 patients having surgery. At baseline, female gender, increasing age at onset, being RF positive and higher DAS scores were each independently associated with increased odds of seeing a podiatrist. Gender, age of onset and baseline DAS were independently associated with the odds of having foot surgery. Despite the known high prevalence of foot pathologies in RA, only one-third of this cohort accessed podiatry. While older females were more likely to access podiatry care and younger patients surgery, the majority of the RA population did not access any foot care.

Application of Deep Learning in GLOBELAND30-2010 Product Refinement

NASA Astrophysics Data System (ADS)

Liu, T.; Chen, X.

2018-04-01

GlobeLand30, as one of the best Global Land Cover (GLC) product at 30-m resolution, has been widely used in many research fields. Due to the significant spectral confusion among different land cover types and limited textual information of Landsat data, the overall accuracy of GlobeLand30 is about 80 %. Although such accuracy is much higher than most other global land cover products, it cannot satisfy various applications. There is still a great need of an effective method to improve the quality of GlobeLand30. The explosive high-resolution satellite images and remarkable performance of Deep Learning on image classification provide a new opportunity to refine GlobeLand30. However, the performance of deep leaning depends on quality and quantity of training samples as well as model training strategy. Therefore, this paper 1) proposed an automatic training sample generation method via Google earth to build a large training sample set; and 2) explore the best training strategy for land cover classification using GoogleNet (Inception V3), one of the most widely used deep learning network. The result shows that the fine-tuning from first layer of Inception V3 using rough large sample set is the best strategy. The retrained network was then applied in one selected area from Xi'an city as a case study of GlobeLand30 refinement. The experiment results indicate that the proposed approach with Deep Learning and google earth imagery is a promising solution for further improving accuracy of GlobeLand30.

32 CFR 727.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... assistance program providing needed legal advice and assistance to military personnel and their dependents... personnel and reduced disciplinary problems since its inception. The purpose of this part is to provide...

Enhancing Diversity in Physics: The Fisk-Vanderbilt Masters-to-PhD Bridge Program

NASA Astrophysics Data System (ADS)

Stassun, Keivan

2010-03-01

We describe the Fisk-Vanderbilt Masters-to-PhD Bridge program as a model for partnering with minority-serving institutions to increase the representation of women and minorities earning PhDs in astronomy and related disciplines. Since its inception in 2004, the Fisk-Vanderbilt Bridge program has attracted 30 minority students, 60% of whom are female, and with a retention rate of 94%. When the first Bridge students completed their PhDs in 2010-11, the program will become the top awarder of astronomy PhDs to underrepresented minorities in the United States. Already, Fisk has become the top producer of physics Masters degrees to African Americans. We summarize the program's structure, approach, and research basis with the goal of providing a replicable model for other institutions seeking to build similar collaborative, research-based bridging partnerships.

Preserve America Event ToolKit

Science.gov Websites

inception in 2003, Preserve America has become an important, multi-faceted, interagency initiative that to help organize those local events. Detailed information about the initiative is at

Toward Primary Prevention of Asthma. Reviewing the Evidence for Early-Life Respiratory Viral Infections as Modifiable Risk Factors to Prevent Childhood Asthma

PubMed Central

Feldman, Amy S.; He, Yuan; Moore, Martin L.; Hershenson, Marc B.

2015-01-01

A first step in primary disease prevention is identifying common, modifiable risk factors that contribute to a significant proportion of disease development. Infant respiratory viral infection and childhood asthma are the most common acute and chronic diseases of childhood, respectively. Common clinical features and links between these diseases have long been recognized, with early-life respiratory syncytial virus (RSV) and rhinovirus (RV) lower respiratory tract infections (LRTIs) being strongly associated with increased asthma risk. However, there has long been debate over the role of these respiratory viruses in asthma inception. In this article, we systematically review the evidence linking early-life RSV and RV LRTIs with asthma inception and whether they could therefore be targets for primary prevention efforts. PMID:25369458

Some observations of tip-vortex cavitation

NASA Astrophysics Data System (ADS)

Arndt, R. E. A.; Arakeri, V. H.; Higuchi, H.

1991-08-01

Cavitation has been observed in the trailing vortex system of an elliptic platform hydrofoil. A complex dependence on Reynolds number and gas content is noted at inception. Some of the observations can be related to tension effects associated with the lack of sufficiently large-sized nuclei. Inception measurements are compared with estimates of pressure in the vortex obtained from LDV measurements of velocity within the vortex. It is concluded that a complete correlation is not possible without knowledge of the fluctuating levels of pressure in tip-vortex flows. When cavitation is fully developed, the observed tip-vortex trajectory flows. When cavitation is fully developed, the observed tip-vortex trajectory shows a surprising lack of dependence on any of the physical parameters varied, such as angle of attack, Reynolds number, cavitation number, and dissolved gas content.

Effects of measurement resolution on the analysis of temperature time series for stream-aquifer flux estimation

NASA Astrophysics Data System (ADS)

Soto-López, Carlos D.; Meixner, Thomas; Ferré, Ty P. A.

2011-12-01

From its inception in the mid-1960s, the use of temperature time series (thermographs) to estimate vertical fluxes has found increasing use in the hydrologic community. Beginning in 2000, researchers have examined the impacts of measurement and parameter uncertainty on the estimates of vertical fluxes. To date, the effects of temperature measurement discretization (resolution), a characteristic of all digital temperature loggers, on the determination of vertical fluxes has not been considered. In this technical note we expand the analysis of recently published work to include the effects of temperature measurement resolution on estimates of vertical fluxes using temperature amplitude and phase shift information. We show that errors in thermal front velocity estimation introduced by discretizing thermographs differ when amplitude or phase shift data are used to estimate vertical fluxes. We also show that under similar circumstances sensor resolution limits the range over which vertical velocities are accurately reproduced more than uncertainty in temperature measurements, uncertainty in sensor separation distance, and uncertainty in the thermal diffusivity combined. These effects represent the baseline error present and thus the best-case scenario when discrete temperature measurements are used to infer vertical fluxes. The errors associated with measurement resolution can be minimized by using the highest-resolution sensors available. But thoughtful experimental design could allow users to select the most cost-effective temperature sensors to fit their measurement needs.

Is it safe for people with epilepsy to donate blood? A systematic review.

PubMed

Kellens, Alyssa; De Buck, Emmy; Emonds, Marie-Paule; Vandekerckhove, Philippe; Lagae, Lieven

2018-01-01

In many countries people with epilepsy are temporarily or permanently excluded from blood donation. This exclusion is based on the assumption that they are more likely to experience adverse donor reactions such as epileptic seizures, and not on scientific evidence. A systematic review was therefore performed to critically examine the evidence with regard to adverse effects of blood donation on epilepsy patients. Five databases (MEDLINE, Embase, The Cochrane Library, Web of Science and CINAHL) were searched for studies from the date of inception until December 2014. Two of the authors screened the articles and extracted the data independently and used the GRADE approach to assess the quality of evidence. The literature search yielded 7283 references. Following title and abstract screening in the first phase, and full text screening in the second phase, only three observational studies were finally withheld: one cohort study and two case series. None of the three studies could demonstrate that a blood donation resulted in adverse events in epilepsy patients. However, the studies were of poor methodological quality and lacked a solid statistical analysis. Limited low quality studies could not demonstrate that blood donors with epilepsy are at an increased risk of adverse events. Further research is necessary to determine whether and how long epilepsy patients have to be excluded from blood donation. Copyright © 2017 Elsevier B.V. All rights reserved.

MPA in Labor: Securing the Pearl Cays of Nicaragua

NASA Astrophysics Data System (ADS)

Gonzalez, Clarence; Jentoft, Svein

2011-04-01

Implementation of Marine Protected Areas (MPAs) has always a step-zero, i.e., an initial phase when the idea is incepted, communicated and negotiated among stakeholders. What happens during this phase is likely to have an impact later on. If not done right, the management of the MPA may encounter problems at later stage that will be difficult to correct. Inspired by this working theory, this article describes the effort to establish the Pearl Cays off the Caribbean coast of Nicaragua as a protected area. This case-study illustrates the critical actions to be taken during step-zero, i.e., what needs to be considered and done before an MPA is formally declared. The area investigated consists of a number of small islands (cays) and coral reefs, fishing grounds and marine turtle nesting areas. Throughout history, the cays have played an important role in sustaining livelihoods of nearby communities. Although the idea of an MPA was originally conservation, the communities saw it as an opportunity to regain ownership and control of the cays. By Nicaraguan law, in order to establish protected areas, consultation and approval from local people is required. In the case of the Pearl Cays, this has proved difficult. The article demonstrates how MPA initiatives must sometimes relate to already ongoing complex social processes in the area where they are to be instigated.

MPA in labor: securing the Pearl Cays of Nicaragua.

PubMed

Gonzalez, Clarence; Jentoft, Svein

2011-04-01

Implementation of Marine Protected Areas (MPAs) has always a step-zero, i.e., an initial phase when the idea is incepted, communicated and negotiated among stakeholders. What happens during this phase is likely to have an impact later on. If not done right, the management of the MPA may encounter problems at later stage that will be difficult to correct. Inspired by this working theory, this article describes the effort to establish the Pearl Cays off the Caribbean coast of Nicaragua as a protected area. This case-study illustrates the critical actions to be taken during step-zero, i.e., what needs to be considered and done before an MPA is formally declared. The area investigated consists of a number of small islands (cays) and coral reefs, fishing grounds and marine turtle nesting areas. Throughout history, the cays have played an important role in sustaining livelihoods of nearby communities. Although the idea of an MPA was originally conservation, the communities saw it as an opportunity to regain ownership and control of the cays. By Nicaraguan law, in order to establish protected areas, consultation and approval from local people is required. In the case of the Pearl Cays, this has proved difficult. The article demonstrates how MPA initiatives must sometimes relate to already ongoing complex social processes in the area where they are to be instigated.

Long-Term Preservation of NASA Heliophysics Data and Access: Where We Were and Where We're Going

NASA Technical Reports Server (NTRS)

McGuire, Robert E.

2011-01-01

The importance of ensuring preservation and useful access to the unique science potential of past, present and future NASA solar and space physics (i.e. heliophysics) data has been recognized since the inception of NASA but remains challenging. In this talk, I will briefly review the history of this topic and and then discuss the present NASA model for heliophysics science data management, including key current resources for finding and using data projects like the Space Physics Data Facility. I will highlight expected future directions, building on working elements of the present program and exploiting new technology, to further improve the data environment, address existing issues and anticipate emerging challenges.

Revise Inc. - Getting Bought Out

NASA Astrophysics Data System (ADS)

Ehrlich, Daniel

2010-03-01

From its inception Revise Inc. was designed to be acquired by a larger firm. Revise was always tightly controlled with no outside investors. As a well-focused company of ten people we were able to engineer a major piece of semiconductor capital equipment, then sell and maintain this product in the field internationally. We made a profit in year one and every succeeding year until we were acquired. This model made us attractive to a publicly-traded acquirer, who saw an opportunity to buy a prepackaged asset that, with low risk, should add to it's earnings ratios. The technology that we brought fit, but the business argument worked with no need to exaggerate the technology's value.

An appraisal of China's progress toward the Millennium Development Goals as they relate to children.

PubMed

Strand, Mark A; Fischer, Philip R

2014-08-01

Since their inception in 2000, the Millennium Development Goals (MDGs) have improved understanding of the global development process. Although the goals will not be significantly achieved on a global scale, each country has had accomplishments deserving of attention and analysis. With regard to the MDGs as they relate to children, China has made significant achievements, the deeper understanding of which might help in the process of refreshing the MDGs beyond 2015. China's accomplishments in economic development and human welfare, and the benefits this has brought to its children potentially teach lessons that can be modelled by other countries moving from low- to middle-income status.

The Conductor-Dielectric Junctions in a Low Density Plasma

NASA Technical Reports Server (NTRS)

Vayner, Boris; Galofaro, Joel; Ferguson, Dale; deGroot, Wim; Thomson, Clint; Dennison, J. R.; Davies, Robert

1999-01-01

A conductor-dielectric junction exposed to the space environment is a frequent spacecraft design feature. Due to spacecraft charging and/or solar array operation, the conductor can acquire a high potential with respect to the surrounding plasma. If this potential is positive the insulators adjacent to exposed conductors can collect current as if they were conductors themselves. This phenomenon, called snapover, results in a substantial increase in current collection, and may even result in a glow discharge if the potential is high enough. If a conductor has a negative potential, arcing can occur at the site of a junction. Both of these phenomena negatively affect spacecraft operation. To prevent negative consequences, the physical mechanisms of snapover and arc inception require investigation. In this paper, results are presented of an experimental and theoretical study of snapover, glow discharge, and arc phenomena for different materials immersed in argon or xenon plasmas. The effect of snapover is investigated for several metal-dielectric junctions: copper-teflon, copper-Kapton, copper-glass, aluminum-teflon, aluminum-Kapton, steel-teflon, anodized aluminum with pinholes, and copper-ceramics. I-V curves are measured and snapover inception voltages, essential parameters (increase in current and collection area due to secondary electrons), and glow discharge inception thresholds are determined. Optical spectra are obtained for glow discharges in both argon and xenon plasmas. These spectra provide information regarding atomic species entrapped in the glow region. Some spectral lines can be used to estimate plasma parameters in the discharge area. A video-camera and linear array were used to confirm that snapover inception is accompanied by very low intensity visible light emission. This result seems to be important for the estimate of the light pollution around spacecraft. Optical spectra (wavelengths 380-650 nm) of arcs are also obtained on a negatively biased chromic acid anodized aluminum plate immersed in low density argon and xenon plasmas. Analysis of these spectra confirms our earlier findings that aluminum atoms are ejected from the arc site. Moreover, it is found that chromium atoms are also quite abundant in the arc plasma. It is believed that the latter results contribute considerably to the understanding of processes of plasma contamination caused by arcing.

Developmental and microbiological analysis of the inception of bioluminescent symbiosis in the marine fish Nuchequula nuchalis (Perciformes: Leiognathidae).

PubMed

Dunlap, Paul V; Davis, Kimberly M; Tomiyama, Shinichi; Fujino, Misato; Fukui, Atsushi

2008-12-01

Many marine fish harbor luminous bacteria as bioluminescent symbionts. Despite the diversity, abundance, and ecological importance of these fish and their apparent dependence on luminous bacteria for survival and reproduction, little is known about developmental and microbiological events surrounding the inception of their symbioses. To gain insight on these issues, we examined wild-caught larvae of the leiognathid fish Nuchequula nuchalis, a species that harbors Photobacterium leiognathi as its symbiont, for the presence, developmental state, and microbiological status of the fish's internal, supraesophageal light organ. Nascent light organs were evident in the smallest specimens obtained, flexion larvae of 6.0 to 6.5 mm in notochord length (NL), a developmental stage at which the stomach had not yet differentiated and the nascent gasbladder had not established an interface with the light organ. Light organs of certain of the specimens in this size range apparently lacked bacteria, whereas light organs of other specimens of 6.5 mm in NL and of all larger specimens harbored large populations of bacteria, representatives of which were identified as P. leiognathi. Bacteria identified as Vibrio harveyi were also present in the light organ of one larval specimen. Light organ populations were composed typically of two or three genetically distinct strain types of P. leiognathi, similar to the situation in adult fish, and the same strain type was only rarely found in light organs of different larval, juvenile, or adult specimens. Light organs of larvae carried a smaller proportion of strains merodiploid for the lux-rib operon, 79 of 249 strains, than those of adults (75 of 91 strains). These results indicate that light organs of N. nuchalis flexion and postflexion larvae of 6.0 to 6.7 mm in NL are at an early stage of development and that inception of the symbiosis apparently occurs in flexion larvae of 6.0 to 6.5 mm in NL. Ontogeny of the light organ therefore apparently precedes acquisition of the symbiotic bacteria. Furthermore, bacterial populations in larval light organs near inception of the symbiosis are genetically diverse, like those of adult fish.

Developmental and Microbiological Analysis of the Inception of Bioluminescent Symbiosis in the Marine Fish Nuchequula nuchalis (Perciformes: Leiognathidae)▿

PubMed Central

Dunlap, Paul V.; Davis, Kimberly M.; Tomiyama, Shinichi; Fujino, Misato; Fukui, Atsushi

2008-01-01

Many marine fish harbor luminous bacteria as bioluminescent symbionts. Despite the diversity, abundance, and ecological importance of these fish and their apparent dependence on luminous bacteria for survival and reproduction, little is known about developmental and microbiological events surrounding the inception of their symbioses. To gain insight on these issues, we examined wild-caught larvae of the leiognathid fish Nuchequula nuchalis, a species that harbors Photobacterium leiognathi as its symbiont, for the presence, developmental state, and microbiological status of the fish's internal, supraesophageal light organ. Nascent light organs were evident in the smallest specimens obtained, flexion larvae of 6.0 to 6.5 mm in notochord length (NL), a developmental stage at which the stomach had not yet differentiated and the nascent gasbladder had not established an interface with the light organ. Light organs of certain of the specimens in this size range apparently lacked bacteria, whereas light organs of other specimens of 6.5 mm in NL and of all larger specimens harbored large populations of bacteria, representatives of which were identified as P. leiognathi. Bacteria identified as Vibrio harveyi were also present in the light organ of one larval specimen. Light organ populations were composed typically of two or three genetically distinct strain types of P. leiognathi, similar to the situation in adult fish, and the same strain type was only rarely found in light organs of different larval, juvenile, or adult specimens. Light organs of larvae carried a smaller proportion of strains merodiploid for the lux-rib operon, 79 of 249 strains, than those of adults (75 of 91 strains). These results indicate that light organs of N. nuchalis flexion and postflexion larvae of 6.0 to 6.7 mm in NL are at an early stage of development and that inception of the symbiosis apparently occurs in flexion larvae of 6.0 to 6.5 mm in NL. Ontogeny of the light organ therefore apparently precedes acquisition of the symbiotic bacteria. Furthermore, bacterial populations in larval light organs near inception of the symbiosis are genetically diverse, like those of adult fish. PMID:18978090

Discontinuing Oxytocin Infusion in the Active Phase of Labor: A Systematic Review and Meta-analysis.

PubMed

Saccone, Gabriele; Ciardulli, Andrea; Baxter, Jason K; Quiñones, Joanne N; Diven, Liany C; Pinar, Bor; Maruotti, Giuseppe Maria; Martinelli, Pasquale; Berghella, Vincenzo

2017-11-01

To evaluate the benefits and harms of discontinuation of oxytocin after the active phase of labor is reached. Electronic databases (ie, MEDLINE, Scopus, ClinicalTrials.gov, EMBASE, ScienceDirect, the Cochrane Library at the CENTRAL Register of Controlled Trials, Scielo) were searched from their inception until April 2017. We included all randomized controlled trials comparing discontinuation (ie, intervention group) and continuation (ie, control group) of oxytocin infusion after the active phase of labor is reached, either after induction or augmentation of labor. Discontinuation of oxytocin infusion was defined as discontinuing oxytocin infusion when the active phase of labor was achieved. Continuation of oxytocin infusion was defined as continuing oxytocin infusion until delivery. Only trials in singleton gestations with vertex presentation at term were included. The primary outcome was the incidence of cesarean delivery. Nine randomized controlled trials, including 1,538 singleton gestations, were identified as relevant and included in the meta-analysis. All nine trials included only women undergoing induction of labor. In the discontinuation group, if arrest of labor occurred, usually defined as no cervical dilation in 2 hours or inadequate uterine contractions for 2 hours or more, oxytocin infusion was restarted. Women in the control group had oxytocin continued until delivery usually at the same dose used at the time the active phase was reached. Women who were randomized to have discontinuation of oxytocin infusion after the active phase of labor was reached had a significantly lower risk of cesarean delivery (9.3% compared with 14.7%; relative risk 0.64, 95% CI 0.48-0.87) and of uterine tachysystole (6.2% compared with 13.1%; relative risk 0.53, 95% CI 0.33-0.84) compared with those who were randomized to have continuation of oxytocin infusion until delivery. Discontinuation of oxytocin infusion was associated with an increase in the duration of the active phase of labor (mean difference 27.65 minutes, 95% CI 3.94-51.36). In singleton gestations with cephalic presentation at term undergoing induction, discontinuation of oxytocin infusion after the active phase of labor at approximately 5 cm is reached reduces the risk of cesarean delivery and of uterine tachysystole compared with continuous oxytocin infusion. Given this evidence, discontinuation of oxytocin infusion once the active stage of labor is established in women being induced should be considered as an alternative management plan.

The vegetation and climate history of the last glacial cycle in a new pollen record from Lake Fimon (southern Alpine foreland, N-Italy)

NASA Astrophysics Data System (ADS)

Pini, R.; Ravazzi, C.; Reimer, P. J.

2010-11-01

The sediments of Lake Fimon, N-Italy, contain the first continuous archive of the Late Pleistocene environmental and climate history of the southern Alpine foreland. We present here the detailed palynological record of the interval between Termination II and the Last Glacial Maximum. The age-depth model is obtained by radiocarbon dating in the uppermost part of the record. Downward, we correlated major forest expansion and contraction events to isotopic events in the Greenland Ice core records, via a stepping-stone approach involving intermediate correlation to isotopic events dated by TIMS U/Th in Alpine and Apennine stalagmites, and to pollen records from marine cores of the Iberian margin. Modelled ages obtained by Bayesian analysis of deposition are thoroughly consistent with actual ages, with maximum offset of ±1700 years. Sharp expansion of broad-leaved temperate forest and of sudden water table rise mark the onset of the Last Interglacial after a treeless steppe phase at the end of penultimate glaciation. This event is actually a two-step process which matches the two-step rise observed in the isotopic record of the nearby Antro del Corchia stalagmite, respectively dated to 132.5 ± 2.5 and 129 ± 1.5 ka. At the interglacial decline mixed oak forests were replaced by oceanic mixed forests, the latter persisting further for 7 ka till the end of the Eemian succession. Warm-temperate woody species are still abundant at the Eemian end, corroborating a steep gradient between central Europe and the Alpine divide at the inception of the last glacial. After a stadial phase marked by moderate forest decline, a new expansion of warm broad-leaved forests, interrupted by minor events and followed by mixed oceanic forests, can be identified with the north-alpine Saint Germain I. The spread of beech during the oceanic phase is a valuable circumalpine marker. The subsequent stadial-interstadial succession, lacking the telocratic oceanic phase, is also consistent with the evidence at the north-alpine foreland. The Middle Würmian (full glacial) is marked by persistence of mixed forests dominated by conifers but with significant lime and other broad-leaved species. A major Arboreal Pollen decrease is observed at modelled age of 38.7 ± 0.5 ka (larch expansion and last occurrence of lime), which has been related to Heinrich Event 4. The evidence of afforestation persisting south of the Alps throughout most of MIS 3 contrasts with a boreal and continental landscape known for the northern alpine foreland, pointing to a sharp rainfall boundary at the Alpine divide and to southern air circulation. This is in agreement with the Alpine paleoglaciological record and is supported by the pressure and rainfall patterns designed by mesoscale paleoclimate simulations. Strenghtening the continental high pressure during the full glacial triggered cyclogenesis in the middle latitude eastern Europe and orographic rainfall in the eastern Alps and the Balkanic mountains, thus allowing forests development at current sea-level altitudes.

A Report on IAU Commission 46: The Teaching of Astronomy

ERIC Educational Resources Information Center

Beetle, Dorothy E.

1974-01-01

Describes the purpose, inception, and services of the International Astronomical Union's Commission 46, which is composed of members from many nations who are interested in the teaching of astronomy. (MLH)

LTPP maintenance and rehabilitation data review

DOT National Transportation Integrated Search

2001-02-01

The maintenance and rehabilitation (M&R) activities of pavement structures become increasingly important as pavements deteriorate with time and traffic. Since its inception, the Long Term Pavement Performance (LTPP) component of the Strategic Highway...

Efficacy of a New Medical Information system, Ubiquitous Healthcare Service with Voice Inception Technique in Elderly Diabetic Patients.

PubMed

Kim, Kyoung Min; Park, Kyeong Seon; Lee, Hyun Ju; Lee, Yun Hee; Bae, Ji Seon; Lee, Young Joon; Choi, Sung Hee; Jang, Hak Chul; Lim, Soo

2015-12-11

We have demonstrated previously that an individualized health management system using advanced medical information technology, named ubiquitous (u)-healthcare, was helpful in achieving better glycemic control than routine care. Recently, we generated a new u-healthcare system using a voice inception technique for elderly diabetic patients to communicate information about their glucose control, physical activity, and diet more easily. In a randomized clinical trial, 70 diabetic patients aged 60-85 years were assigned randomly to a standard care group or u-healthcare group for 6 months. The primary end points were the changes in glycated hemoglobin (HbA1c) and glucose fluctuation assessed by the mean amplitude glycemic excursion (MAGE). Changes in body weight, lifestyle, and knowledge about diabetes were also investigated. After 6 months, the HbA1c levels decreased significantly in the u-healthcare group (from 8.6 ± 1.0% to 7.5 ± 0.6%) compared with the standard care group (from 8.7 ± 0.9% to 8.2 ± 1.1%, P < 0.01). The MAGE decreased more in the u-healthcare group than in the standard care group. Systolic blood pressure and body weight decreased and liver functions improved in the u-healthcare group, but not in the standard care group. The u-healthcare system with voice inception technique was effective in achieving glycemic control without hypoglycemia in elderly diabetic patients (Clinicaltrials.gov: NCT01891474).

3D multi-view convolutional neural networks for lung nodule classification

PubMed Central

Kang, Guixia; Hou, Beibei; Zhang, Ningbo

2017-01-01

The 3D convolutional neural network (CNN) is able to make full use of the spatial 3D context information of lung nodules, and the multi-view strategy has been shown to be useful for improving the performance of 2D CNN in classifying lung nodules. In this paper, we explore the classification of lung nodules using the 3D multi-view convolutional neural networks (MV-CNN) with both chain architecture and directed acyclic graph architecture, including 3D Inception and 3D Inception-ResNet. All networks employ the multi-view-one-network strategy. We conduct a binary classification (benign and malignant) and a ternary classification (benign, primary malignant and metastatic malignant) on Computed Tomography (CT) images from Lung Image Database Consortium and Image Database Resource Initiative database (LIDC-IDRI). All results are obtained via 10-fold cross validation. As regards the MV-CNN with chain architecture, results show that the performance of 3D MV-CNN surpasses that of 2D MV-CNN by a significant margin. Finally, a 3D Inception network achieved an error rate of 4.59% for the binary classification and 7.70% for the ternary classification, both of which represent superior results for the corresponding task. We compare the multi-view-one-network strategy with the one-view-one-network strategy. The results reveal that the multi-view-one-network strategy can achieve a lower error rate than the one-view-one-network strategy. PMID:29145492

Physics based modeling of axial compressor stall

NASA Astrophysics Data System (ADS)

Zaki, Mina Adel

2009-12-01

Axial compressors are used in a wide variety of aerodynamic applications and are one of the most important components in aero-engines. However, the operability of compressors is limited at low-mass flow rates by fluid dynamic instabilities such as stall and surge. These instabilities can lead to engine failure and loss of engine power which can compromise the aircraft safety and reliability. Thus, a better understanding of how stall occurs and the causes behind its inception is extremely important. In the vicinity of the stall line, the flow field is inherently unsteady due to the interactions between adjacent rows of blades, formation of separation cells, and the viscous effects including shock-boundary layer interactions. Accurate modeling of these phenomena requires a proper set of stable and accurate boundary conditions at the rotor-stator interface that conserve mass, momentum, and energy, while eliminating false reflections. As a part of this research effort, an existing 3-D Navier-Stokes analysis for modeling single stage compressors has been modified to model multi-stage axial compressors and turbines. Several rotor-stator interface boundary conditions have been implemented. These conditions have been evaluated for the first stage (a stator and a rotor) of the two-stage fuel turbine on the space shuttle main engine (SSME). Their effectiveness in conserving global properties such as mass, momentum, and energy across the interface while yielding good performance predictions has been evaluated. While all the methods gave satisfactory results, a characteristic based approach and an unsteady sliding mesh approach are found to work best. Accurate modeling of the formation of stall cells requires the use of advanced turbulence models. As a part of this effort, a new advanced turbulence model called the Hybrid RANS/KES (HRKES) model has been developed and implemented. This model solves the Menter's k-o-SST model near walls and switches to the Kinetic Eddy Simulation (KES) model away from walls. The KES model solves directly for local turbulent kinetic energy and local turbulent length scales, alleviating the grid spacing dependency of the length scales found in other Detached Eddy Simulation (DES) and Hybrid RANS/LES (HRLES) models. Within the HRKES model, combinations of two different blending functions have been evaluated for integrating the near wall model with the KES model. The use of realizability constraints to bound the KES model parameters has also been studied for several internal and external flows. The current methodology is used in the prediction of the performance map for the NASA Stage 35 compressor configuration as a representative of a modern compressor stage. The present approach is found to effectively predict the onset of stall. It is found that the rotor blade tip leakage vortex and its interaction with the shock wave is mainly the reason behind the stall inception in this compressor stage.

Exposure age and ice-sheet model constraints on Pliocene East Antarctic ice sheet dynamics.

PubMed

Yamane, Masako; Yokoyama, Yusuke; Abe-Ouchi, Ayako; Obrochta, Stephen; Saito, Fuyuki; Moriwaki, Kiichi; Matsuzaki, Hiroyuki

2015-04-24

The Late Pliocene epoch is a potential analogue for future climate in a warming world. Here we reconstruct Plio-Pleistocene East Antarctic Ice Sheet (EAIS) variability using cosmogenic nuclide exposure ages and model simulations to better understand ice sheet behaviour under such warm conditions. New and previously published exposure ages indicate interior-thickening during the Pliocene. An ice sheet model with mid-Pliocene boundary conditions also results in interior thickening and suggests that both the Wilkes Subglacial and Aurora Basins largely melted, offsetting increased ice volume. Considering contributions from West Antarctica and Greenland, this is consistent with the most recent IPCC AR5 estimate, which indicates that the Pliocene sea level likely did not exceed +20 m on Milankovitch timescales. The inception of colder climate since ∼3 Myr has increased the sea ice cover and inhibited active moisture transport to Antarctica, resulting in reduced ice sheet thickness, at least in coastal areas.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sudarchikova, Natalia; Mikolajewicz, Uwe; Timmreck, C.

The mineral dust cycle responds to climate variations and plays an important role in the climate system by affecting the radiative balance of the atmosphere and modifying biogeochemistry. Polar ice cores provide unique information about deposition of aeolian dust particles transported over long distances. These cores are a palaeoclimate proxy archive of climate variability thousands of years ago. The current study is a first attempt to simulate past interglacial dust cycles with a global aerosol–climate model ECHAM5-HAM. The results are used to explain the dust deposition changes in Antarctica in terms of quantitative contribution of different processes, such as emission,more » atmospheric transport and precipitation, which will help to interpret palaeodata from Antarctic ice cores. The investigated periods include four interglacial time slices: the pre-industrial control (CTRL), mid-Holocene (6000 yr BP; hereafter referred to as \\"6 kyr\\"), last glacial inception (115 000 yr BP; hereafter \\"115 kyr\\") and Eemian (126 000 yr BP; hereafter \\"126 kyr\\"). One glacial time interval, the Last Glacial Maximum (LGM) (21 000 yr BP; hereafter \\"21 kyr\\"), was simulated as well to be a reference test for the model. Results suggest an increase in mineral dust deposition globally, and in Antarctica, in the past interglacial periods relative to the pre-industrial CTRL simulation. Approximately two-thirds of the increase in the mid-Holocene and Eemian is attributed to enhanced Southern Hemisphere dust emissions. Slightly strengthened transport efficiency causes the remaining one-third of the increase in dust deposition. The moderate change in dust deposition in Antarctica in the last glacial inception period is caused by the slightly stronger poleward atmospheric transport efficiency compared to the pre-industrial. Maximum dust deposition in Antarctica was simulated for the glacial period. LGM dust deposition in Antarctica is substantially increased due to 2.6 times higher Southern Hemisphere dust emissions, 2 times stronger atmospheric transport towards Antarctica, and 30% weaker precipitation over the Southern Ocean. The model is able to reproduce the order of magnitude of dust deposition globally and in Antarctica for the pre-industrial and LGM climates.« less

Audio teleconferencing: creative use of a forgotten innovation.

PubMed

Mather, Carey; Marlow, Annette

2012-06-01

As part of a regional School of Nursing and Midwifery's commitment to addressing recruitment and retention issues, approximately 90% of second year undergraduate student nurses undertake clinical placements at: multipurpose centres; regional or district hospitals; aged care; or community centres based in rural and remote regions within the State. The remaining 10% undertake professional experience placement in urban areas only. This placement of a large cohort of students, in low numbers in a variety of clinical settings, initiated the need to provide consistent support to both students and staff at these facilities. Subsequently the development of an audio teleconferencing model of clinical facilitation to guide student teaching and learning and to provide support to registered nurse preceptors in clinical practice was developed. This paper draws on Weimer's 'Personal Accounts of Change' approach to describe, discuss and evaluate the modifications that have occurred since the inception of this audio teleconferencing model (Weimer, 2006).

Regenerative medicine in otorhinolaryngology.

PubMed

Wormald, J C R; Fishman, J M; Juniat, S; Tolley, N; Birchall, M A

2015-08-01

Tissue engineering using biocompatible scaffolds, with or without cells, can permit surgeons to restore structure and function following tissue resection or in cases of congenital abnormality. Tracheal regeneration has emerged as a spearhead application of these technologies, whilst regenerative therapies are now being developed to treat most other diseases within otolaryngology. A systematic review of the literature was performed using Ovid Medline and Ovid Embase, from database inception to 15 November 2014. A total of 561 papers matched the search criteria, with 76 fulfilling inclusion criteria. Articles were predominantly pre-clinical animal studies, reflecting the current status of research in this field. Several key human research articles were identified and discussed. The main issues facing research in regenerative surgery are translation of animal model work into human models, increasing stem cell availability so it can be used to further research, and development of better facilities to enable implementation of these advances.

Theoretical analysis of ozone generation by pulsed dielectric barrier discharge in oxygen

NASA Astrophysics Data System (ADS)

Wei, L. S.; Zhou, J. H.; Wang, Z. H.; Cen, K. F.

2007-08-01

The use of very short high-voltage pulses combined with a dielectric layer results in high-energy electrons that dissociate oxygen molecules into atoms, which are a prerequisite for the subsequent production of ozone by collisions with oxygen molecules and third particles. The production of ozone depends on both the electrical and the physical parameters. For ozone generation by pulsed dielectric barrier discharge in oxygen, a mathematical model, which describes the relation between ozone concentration and these parameters that are of importance in its design, is developed according to dimensional analysis theory. A formula considering the ozone destruction factor is derived for predicting the characteristics of the ozone generation, within the range of the corona inception voltage to the gap breakdown voltage. The trend showing the dependence of the concentration of ozone in oxygen on these parameters generally agrees with the experimental results, thus confirming the validity of the mathematical model.

Worklife After Traumatic Spinal Cord Injury

PubMed Central

Pflaum, Christopher; McCollister, George; Strauss, David J; Shavelle, Robert M; DeVivo, Michael J

2006-01-01

Objective: To develop predictive models to estimate worklife expectancy after spinal cord injury (SCI). Design: Inception cohort study. Setting: Model SCI Care Systems throughout the United States. Participants: 20,143 persons enrolled in the National Spinal Cord Injury Statistical Center database since 1973. Intervention: Not applicable. Main Outcome Measure: Postinjury employment rates and worklife expectancy. Results: Using logistic regression, we found a greater likelihood of being employed in any given year to be significantly associated with younger age, white race, higher education level, being married, having a nonviolent cause of injury, paraplegia, ASIA D injury, longer time postinjury, being employed at injury and during the previous postinjury year, higher general population employment rate, lower level of Social Security Disability Insurance benefits, and calendar years after the passage of the Americans with Disabilities Act. Conclusions: The likelihood of postinjury employment varies substantially among persons with SCI. Given favorable patient characteristics, worklife should be considerably higher than previous estimates. PMID:17044388

Towards a three-component model of fan loyalty: a case study of Chinese youth.

PubMed

Zhang, Xiao-xiao; Liu, Li; Zhao, Xian; Zheng, Jian; Yang, Meng; Zhang, Ji-qi

2015-01-01

The term "fan loyalty" refers to the loyalty felt and expressed by a fan towards the object of his/her fanaticism in both everyday and academic discourses. However, much of the literature on fan loyalty has paid little attention to the topic from the perspective of youth pop culture. The present study explored the meaning of fan loyalty in the context of China. Data were collected by the method of in-depth interviews with 16 young Chinese people aged between 19 and 25 years who currently or once were pop fans. The results indicated that fan loyalty entails three components: involvement, satisfaction, and affiliation. These three components regulate the process of fan loyalty development, which can be divided into four stages: inception, upgrade, zenith, and decline. This model provides a conceptual explanation of why and how young Chinese fans are loyal to their favorite stars. The implications of the findings are discussed.

Systolic Blood Pressure and Incident Heart Failure in the Elderly

PubMed Central

Butler, Javed; Kalogeropoulos, Andreas P.; Georgiopoulou, Vasiliki V.; Bibbins-Domingo, Kirsten; Najjar, Samer S.; Sutton-Tyrrell, Kim C.; Harris, Tamara B.; Kritchevsky, Stephen B.; Lloyd-Jones, Donald M.; Newman, Anne B.; Psaty, Bruce M.

2013-01-01

Objectives The exact form of the association between systolic blood pressure (SBP) and heart failure (HF) risk in the elderly remains incompletely defined, especially in individuals not receiving antihypertensive medications. Our aim was to examine the association between SBP and HF risk in the elderly. Design Competing-risks proportional hazards modeling of incident HF risk, utilizing 10-year follow-up data from two NIH-sponsored cohort studies; the Cardiovascular Health Study (inception: 1989-90 and 1992-93) and the Health ABC Study (inception: 1997-98). Setting Community-based cohorts. Participants 4408 participants (age, 72.8 [4.9] years; 53.1% women, 81.7% white; 18.3% black) without prevalent HF and not receiving antihypertensive medications at baseline. Main outcome measures Incident HF, defined as first adjudicated hospitalisation for HF. Results Over 10 years, 493 (11.1%) participants developed HF. Prehypertension (120-139 mmHg), stage 1 (140-159 mmHg), and stage 2 (≥160 mmHg) hypertension were associated with escalating HF risk; hazard ratios vs. optimal SBP (<120 mmHg) in competing-risks models controlling for clinical characteristics were 1.63 (95% CI, 1.23-2.16; P=0.001), 2.21 (95% CI, 1.65-2.96; P<0.001), and 2.60 (95% CI, 1.85-364; P<0.001), respectively. Overall 255 of 493 (51.7%) HF events occurred in participants with SBP <140 mm Hg at baseline. Increasing SBP was associated with higher HF risk in women than men; no race-SBP interaction was observed. In analyses with continuous SBP, HF risk had a continuous positive association with SBP to levels as low as 113 mmHg in men and 112 mmHg in women. Conclusions There is a continuous positive association between SBP and HF risk in the elderly for levels of SBP as low as <115 mmHg; over half of incident HF events occur in individuals with SBP <140 mmHg. PMID:21636845

NASA's THEMIS Mission: Multipoint Observations of Substorms, the Foreshock, and the Magnetopause

NASA Technical Reports Server (NTRS)

Sibeck, D. G.; Angelopoulos, V.; Kuznetsova, M.; Glabmeier, K.-H.; McFadden. J. P.

2008-01-01

From launch on February 17 through the repositioning to final orbits that began in September 2007, the five-spacecraft of the THEMIS mission operated nominally in nearly identical 14.6 RE apogee near-equatorial orbits. On March 23, while aligned from east to west in the duskside magnetotail, the spacecraft observed two substorm sequences in fast survey mode. Timing the motion of these signatures served as an early proof of concept for the main phase of the mission: particle injection and dipolarization signatures propagated duskward from one probe to another, as did auroral intensifications seen by the dedicated array of ground-based observatories. During the summer of 2007, the spacecraft were on the dayside, where the three inner spacecraft (C, D, E) were separated by 100-500 km and the two outer probes (B, -4) by 5,000 - 10,000 km. Here the THEMIS probes repeatedly encountered the magnetopause and bow shock, dissecting flux transfer events (FTEs), determining the instantaneous width of the low-latitude boundary layer, and simultaneously observing hot flow anomalies upstream and downstream from the bow shock at the moment of their inception. From January to March 2008, the spacecraft were in the Earths magnetotail with apogees of 31.0, 19.5, 11.8 (2) and 10.0 RE corresponding to periods of 4, 2, and 1 days. Radial alignments once each four days offered an opportunity to pinpoint when and where substorms begin. This talk reviews THEMIS discoveries to date, with an emphasis on model-data comparisons of FTE characteristics

Economic Models of Preventive Dentistry for Australian Children and Adolescents: A Systematic Review.

PubMed

Tonmukayakul, Utsana; Sia, Kah-Ling; Gold, Lisa; Hegde, Shalika; de Silva, Andrea M; Moodie, Marj

2015-01-01

To identify economic evaluation models and parameters that could be replicated or adapted to construct a generic model to assess cost-effectiveness of and prioritise a wide range of community-based oral disease prevention programmes in an Australian context. The literature search was conducted using MEDLINE, ERIC, PsycINFO, CINHAL (EBSCOhost), EMBASE (Ovid), CRD, DARE, NHSEED, HTA, all databases in the Cochrane library, Scopus and ScienceDirect databases from their inception to November 2012. Thirty-three articles met the criteria for inclusion in this review (7 were Australian studies, 26 articles were international). Existing models focused primarily on dental caries. Periodontal disease, another common oral health problem, was lacking. Among caries prevention studies, there was an absence of clear evidence showing continuous benefits from primary through to permanent dentition and the long-term effects of oral health promotion. No generic model was identified from previous studies that could be immediately adopted or adapted for our purposes of simulating and prioritising a diverse range of oral health interventions for Australian children and adolescents. Nevertheless, data sources specified in the existing Australian-based models will be useful for developing a generic model for such purposes.

Use of conservative and surgical foot care in an inception cohort of patients with rheumatoid arthritis

PubMed Central

Keenan, Anne-Maree; Hensor, Elizabeth M. A.; Young, Adam; James, David; Dixey, Josh; Williams, Peter; Prouse, Peter; Gough, Andrew; Helliwell, Philip S.; Redmond, Anthony C.

2011-01-01

Objectives. To describe conservative and surgical foot care in patients with RA in England and explore factors that predict the type of foot care received. Methods. Use of podiatry and type of foot surgery were outcomes recorded in an inception cohort involving nine rheumatology centres that recruited patients with RA between 1986 and 1998 across England. Associations between patient-specific factors and service use were identified using univariate logistic regression analyses. The independence of these associations was then verified through multiple binary logistic regression modelling. Results. Data were collected on 1237 patients with RA [66.9% females, mean (s.d.) age at disease onset = 54.36 (14.18) years, median DAS = 4.09 (1st quartile = 3.04, 3rd quartile = 5.26), median HAQ = 1 (0.50, 1.63)]. Interventions involving the feet in the cohort were low with only 364 (30%) out of 1218 receiving podiatry and 47 (4%) out of 1237 patients having surgery. At baseline, female gender, increasing age at onset, being RF positive and higher DAS scores were each independently associated with increased odds of seeing a podiatrist. Gender, age of onset and baseline DAS were independently associated with the odds of having foot surgery. Conclusions. Despite the known high prevalence of foot pathologies in RA, only one-third of this cohort accessed podiatry. While older females were more likely to access podiatry care and younger patients surgery, the majority of the RA population did not access any foot care. PMID:21504991

Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis.

PubMed

Kim, Ji Suk; Pak, Kyoungjune; Goh, Tae Sik; Jeong, Dae Cheon; Han, Myoung Eun; Kim, Jihyun; Oh, Sae Ock; Kim, Chi Dae; Kim, Yun Hak

2018-06-01

Coronary artery diseases (CADs) are the leading causes of death in the world. Recent studies have reported that differentially expressed microRNAs (miRNAs) are associated with prognosis or major adverse cardiac events (MACEs) in CAD patients. In a previous meta-analysis, the authors made serious mistakes that we aimed to correct through an updated systematic review and meta-analysis of the prognostic value of altered miRNAs in patients with CADs. We performed a systematic search of MEDLINE (from inception to May 2017) and EMBASE (from inception to May 2017) for English-language publications. Studies of CADs with results on miRNAs that reported survival data or MACEs were included. Data were extracted from each publication independently by two reviewers. After reviewing 515 articles, a total eight studies were included in this study. We measured pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of miRNA 133a with a fixed-effect model (pooled HR, 2.35; 95% CI, 1.56-3.55). High expression of miRNA 133a, 208b, 126, 197, 223, and 122-5p were associated with high mortality. Additionally, high levels of miRNA 208b, 499-5p, 134, 328, and 34a were related with MACEs. The present study confirmed that miRNA 133a, which was associated with high mortality in CAD patients, holds prognostic value in CAD. More importantly, this study corrected issues raised against a prior meta-analysis and provides accurate information. © Copyright: Yonsei University College of Medicine 2018.

Cost analysis and cost determinants in a European inflammatory bowel disease inception cohort with 10 years of follow-up evaluation.

PubMed

Odes, Selwyn; Vardi, Hillel; Friger, Michael; Wolters, Frank; Russel, Maurice G; Riis, Lene; Munkholm, Pia; Politi, Patrizia; Tsianos, Epameinondas; Clofent, Juan; Vermeire, Severine; Monteiro, Estela; Mouzas, Iannis; Fornaciari, Giovanni; Sijbrandij, Jildou; Limonard, Charles; Van Zeijl, Gilbert; O'morain, Colm; Moum, Bjørn; Vatn, Morten; Stockbrugger, Reinhold

2006-09-01

Economic analysis in chronic diseases is a prerequisite for planning a proper distribution of health care resources. We aimed to determine the cost of inflammatory bowel disease, a lifetime illness with considerable morbidity. We studied 1321 patients from an inception cohort in 8 European countries and Israel over 10 years. Data on consumption of resources were obtained retrospectively. The cost of health care was calculated from the use of resources and their median prices. Data were analyzed using regression models based on the generalized estimating equations approach. The mean annual total expenditure on health care was 1871 Euro/patient-year for inflammatory bowel disease, 1524 Euro/patient-year for ulcerative colitis, and 2548 Euro/patient-year for Crohn's disease (P < .001). The most expensive resources were medical and surgical hospitalizations, together accounting for 63% of the cost in Crohn's disease and 45% in ulcerative colitis. Total and hospitalization costs were much higher in the first year after diagnosis than in subsequent years. Differences in medical and surgical hospitalizations were the primary cause of substantial intercountry variations of cost; the mean cost of health care was 3705 Euro/patient-year in Denmark and 888 Euro/patient-year in Norway. The outlay for mesalamine, a costly medication with extensive use, was greater than for all other drugs combined. Patient age at diagnosis and sex did not affect costs. In this multinational, population-based, time-dependent characterization of the health care cost of inflammatory bowel disease, increased expenditure was driven largely by country, diagnosis, hospitalization, and follow-up year.

Emergency vehicle alert system (EVAS)

NASA Technical Reports Server (NTRS)

Reed, Bill; Crump, Roger; Harper, Warren; Myneni, Krishna

1995-01-01

The Emergency Vehicle Alert System (EVAS) program is sponsored by the NASA/MSFC Technology Utilization (TU) office. The program was conceived to support the needs of hearing impaired drivers. The objective of the program is to develop a low-cost, small device which can be located in a personal vehicle and warn the driver, via a visual means, of the approach of an emergency vehicle. Many different technologies might be developed for this purpose and each has its own advantages and drawbacks. The requirements for an acoustic detection system, appear to be pretty stringent and may not allow the development of a reliable, low-cost device in the near future. The problems include variations in the sirens between various types of emergency vehicles, distortions due to wind and surrounding objects, competing background noise, sophisticated signal processing requirements, and omni-directional coverage requirements. Another approach is to use a Radio Frequency (RF) signal between the Emergency Vehicle (EV) and the Personal Vehicle (PV). This approach requires a transmitter on each EV and a receiver in each PV, however it is virtually assured that a system can be developed which works. With this approach, the real technology issue is how to make a system work as inexpensively as possible. This report gives a brief summary of the EVAS program from its inception and concentrates on describing the activities that occurred during Phase 4. References 1-3 describe activities under Phases 1-3. In the fourth phase of the program, the major effort to be expended was in development of the microcontroller system for the PV, refinement of some system elements and packaging for demonstration purposes. An EVAS system was developed and demonstrated which used standard spread spectrum modems with minor modifications.

Effect of Phototherapy on the Reliability of Transcutaneous Bilirubin Devices in Term and Near-Term Infants: A Systematic Review and Meta-Analysis.

PubMed

Nagar, Gaurav; Vandermeer, Ben; Campbell, Sandy; Kumar, Manoj

2016-01-01

Transcutaneous bilirubin (TcB) devices are commonly used for screening of hyperbilirubinemia in term and near-term infants not exposed to phototherapy. However, the accuracy of TcB devices in infants exposed to phototherapy is unclear. To conduct a systematic review of studies comparing TcB devices with total serum bilirubin (TSB) in infants receiving phototherapy or in the postphototherapy phase. MEDLINE, EMBASE, Cochrane Library, CINAHL and Scopus databases (from inception to May 8, 2014) were searched. Additional citations were identified from the bibliography of selected articles and from the abstracts of conference proceedings. The studies were included if they compared TcB results with TSB in term and near-term infants during phototherapy or after discontinuation of phototherapy. Two reviewers independently assessed studies for inclusion, and discrepancies were resolved with consensus. Risk of bias was assessed using the QUADAS-2 tool. Fourteen studies were identified. The pooled estimates of correlation coefficients (r) during phototherapy were: covered sites 0.71 (95% CI 0.64-0.77, 11 studies), uncovered sites 0.65 (95% CI 0.55-0.74), 8 studies), forehead 0.70 (95% CI 0.64-0.75, 12 studies) and sternum 0.64 (95% CI 0.43-0.77, 5 studies). Two studies also provided results as Bland-Altman difference plots (mean TcB-TSB differences -29.2 and 30 µmol/l, respectively). The correlation coefficient improved marginally in the postphototherapy phase (r = 0.72, 95% CI 0.64-0.78, 4 studies). We found a moderate correlation between TcB and TSB during phototherapy with a marginal improvement in the postphototherapy phase. Further research is needed before the use of TcB devices can be recommended for these settings. © 2016 S. Karger AG, Basel.

Game-theoretic analysis of dynamic traffic equilibria.

DOT National Transportation Integrated Search

2014-03-01

Dynamic traffic assignment has grown steadily in popularity and use since its inception. It has become an : important and permanent tool in transportation agencies across the country. However, the exact nature of : dynamic traffic equilibrium, includ...

Deverbal Nominals and Telicity in Japanese.

ERIC Educational Resources Information Center

Tsujimura, Natsuko; Iida, Masayo

1999-01-01

Investigates deverbal nominalization involving the suffix "kake" in Japanese. Argues that kake nominalization induces two different meanings, the halfway and the inception reading, and different constraints are called for depending on these two meanings. (Author/VWL)

Assessing the Army’s Software Patch Management Process

DTIC Science & Technology

2016-03-04

25 Data Collection .................................................................................................................... 26 iv...29 Collected Data ...University (DAU). Since the inception of the APG SSCF in 2009, the SRP implementation has emphasized the use of survey design and data collection. In January

12 CFR 616.6300 - Leasing policies, procedures, and underwriting standards.

Code of Federal Regulations, 2010 CFR

2010-01-01

... at the inception of the lease; (b) Process for estimating the leased asset's market value during the...) Classification of leases in accordance with generally accepted accounting principles; and (k) Tax treatment of...

School-based travel : a mobility assessment

DOT National Transportation Integrated Search

2011-02-01

This project contributes to developing a technical infrastructure to support the Safe Routes to School (SRTS) Program, : specifically to monitor its growth and to evaluate its effectiveness. Since its inception in 2005, the SRTS program : mandated by...

A PDS Narrative: Fostering Renewal, Democracy, and Social Justice in Education

ERIC Educational Resources Information Center

Rowe, Karen; Urban, Elizabeth; Middleton, Valerie

2016-01-01

This article chronicles the inception, growth, and continued impact of a Professional Development School partnership based on teaching practices that acculturate preservice and practicing teachers into teaching for participation in a democracy.

48 CFR 16.305 - Cost-plus-award-fee contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... consisting of (a) a base amount (which may be zero) fixed at inception of the contract and (b) an award amount, based upon a judgmental evaluation by the Government, sufficient to provide motivation for...

What Adherence Measures Should Be Used in Trials of Home-Based Rehabilitation Interventions? A Systematic Review of the Validity, Reliability, and Acceptability of Measures.

PubMed

Frost, Rachael; Levati, Sara; McClurg, Doreen; Brady, Marian; Williams, Brian

2017-06-01

To systematically review methods for measuring adherence used in home-based rehabilitation trials and to evaluate their validity, reliability, and acceptability. In phase 1 we searched the CENTRAL database, NHS Economic Evaluation Database, and Health Technology Assessment Database (January 2000 to April 2013) to identify adherence measures used in randomized controlled trials of allied health professional home-based rehabilitation interventions. In phase 2 we searched the databases of MEDLINE, Embase, CINAHL, Allied and Complementary Medicine Database, PsycINFO, CENTRAL, ProQuest Nursing and Allied Health, and Web of Science (inception to April 2015) for measurement property assessments for each measure. Studies assessing the validity, reliability, or acceptability of adherence measures. Two reviewers independently extracted data on participant and measure characteristics, measurement properties evaluated, evaluation methods, and outcome statistics and assessed study quality using the COnsensus-based Standards for the selection of health Measurement INstruments checklist. In phase 1 we included 8 adherence measures (56 trials). In phase 2, from the 222 measurement property assessments identified in 109 studies, 22 high-quality measurement property assessments were narratively synthesized. Low-quality studies were used as supporting data. StepWatch Activity Monitor validly and acceptably measured short-term step count adherence. The Problematic Experiences of Therapy Scale validly and reliably assessed adherence to vestibular rehabilitation exercises. Adherence diaries had moderately high validity and acceptability across limited populations. The Borg 6 to 20 scale, Bassett and Prapavessis scale, and Yamax CW series had insufficient validity. Low-quality evidence supported use of the Joint Protection Behaviour Assessment. Polar A1 series heart monitors were considered acceptable by 1 study. Current rehabilitation adherence measures are limited. Some possess promising validity and acceptability for certain parameters of adherence, situations, and populations and should be used in these situations. Rigorous evaluation of adherence measures in a broader range of populations is needed. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Improving the prediction of the final part geometry in high strength steels U drawing by means of advanced material and friction models

NASA Astrophysics Data System (ADS)

de Argandoña, Eneko Saenz; Mendiguren, Joseba; Otero, Irune; Mugarra, Endika; Otegi, Nagore; Galdos, Lander

2018-05-01

Steel has been used in vehicles from the automotive industry's inception. Different steel grades are continually being developed in order to satisfy new fuel economy requirements. For example, advanced high strength steel grades (AHSS) are widely used due to their good strength/weight ratio. Because each steel grade has a different microstructure composition and hardness, they show different behaviors when they are subjected to different strain paths. Similarly, the friction behavior when using different contact pressures is considerably altered. In the present paper, four different steel grades, ZSt380, DP600, DP780 and Fortiform 1050 materials are deeply characterized using uniaxial and cyclic tension-compression tests. Coefficient of friction (COF) is also obtained using strip drawing tests. These results have been used to calibrate mixed kinematic-hardening material models as well as pressure dependent friction models. Finally, the geometrical accuracy of the different material and friction models has been evaluated by comparing the numerical predictions with experimental demonstrators obtained using a U-Drawing tester.

Analysis of the lightning-attractive radius for wind turbines considering the developing process of positive attachment leader

NASA Astrophysics Data System (ADS)

Yang, Ning; Zhang, Qilin; Hou, Wenhao; Wen, Ying

2017-03-01

In this paper, we have presented the upward leader propagation model, considering the transition of stream leader process by the finite element method and analyzing the inception and subsequent physical processes of upward leader and the attractive radius for large wind turbines. For validating our model, the comparison of simulated results with the optically high-speed video observation shows that the model can predict an accepted result of upward leader from a 163 m tall tower, the simulated upward leader velocity and length before final jump are 2.3 × 105 m/s and 187.67 m presented by Warner (2010), which are very similar to the observed results of 2.8 × 105 m/s and 184 m, respectively. At the same time, we find that the assumed constant speed ratio of downward/upward leader is improper and cannot accurately predict the attractive radius by lightning strike. Also, the simulated results are compared with the widely used EGM (electro geometric model), and it is found that the EGM has an obvious underestimation of attractive radius more than 50%.

Establishment and outcomes of a model primary care pharmacy service system.

PubMed

Carmichael, Jannet M; Alvarez, Autumn; Chaput, Ryan; DiMaggio, Jennifer; Magallon, Heather; Mambourg, Scott

2004-03-01

The establishment and outcomes of a model primary care pharmacy service system are described. A primary care pharmacy practice model was established at a government health care facility in March 1996. The original objective was to establish a primary pharmacy practice model that would demonstrate improved patient outcomes and maximize the pharmacist's contributions to drug therapy. Since its inception, many improvements have been realized and supported by advanced computer and automated systems, expanded disease state management practices, and unique practitioner and administrative support. Many outcomes studies have been performed on the pharmacist-initiated and -managed clinics, leading to improved patient care and conveying the quality-conscious and cost-effective role pharmacists can play as independent practitioners in this environment. These activities demonstrate cutting-edge leadership in health-system pharmacy. Redesign has been used to improve consistent access to a medication expert and has significantly improved the quality of patient care while easing physicians' workload without increasing health care costs. A system using pharmacists as independent practitioners to promote primary care has achieved high-quality and cost-effective patient care.

The physics of biofilms—an introduction

NASA Astrophysics Data System (ADS)

Mazza, Marco G.

2016-05-01

Biofilms are complex, self-organized consortia of microorganisms that produce a functional, protective matrix of biomolecules. Physically, the structure of a biofilm can be described as an entangled polymer network which grows and changes under the effect of gradients of nutrients, cell differentiation, quorum sensing, bacterial motion, and interaction with the environment. Its development is complex, and constantly adapting to environmental stimuli. Here, we review the fundamental physical processes that govern the inception, growth and development of a biofilm. Two important mechanisms guide the initial phase in a biofilm life-cycle: (i) the cell motility near or at a solid interface, and (ii) the cellular adhesion. Both processes are crucial for initiating the colony and for ensuring its stability. A mature biofilm behaves as a viscoelastic fluid with a complex, history-dependent dynamics. We discuss progress and challenges in the determination of its physical properties. Experimental and theoretical methods are now available that aim at integrating the biofilm’s hierarchy of interactions, and the heterogeneity of composition and spatial structures. We also discuss important directions in which future work should be directed.

New operation strategy for driving the selectivity of NO x reduction to N 2, NH 3 or N 2O during lean/rich cycling of a lean NO x trap catalyst

DOE PAGES

Mráček, David; Koci, Petr; Choi, Jae -Soon; ...

2015-09-08

Periodical regeneration of NO x storage catalyst (also known as lean NO x trap) by short rich pulses of CO, H 2 and hydrocarbons is necessary for the reduction of nitrogen oxides adsorbed on the catalyst surface. Ideally, the stored NO x is converted into N 2, but N 2O and NH 3 by-products can be formed as well, particularly at low-intermediate temperatures. The N 2 and N 2O products are formed concurrently in two peaks. The primary peaks appear immediately after the rich-phase inception, and tail off with the breakthrough of the reductant front accompanied by NH 3 product.more » In addition, the secondary N 2 and N 2O peaks then appear at the rich-to-lean transition as a result of reactions between surface-deposited reductants/intermediates (CO, HC, NH 3, — NCO) and residual stored NO x under increasingly lean conditions.« less

Tuning and Robustness Analysis for the Orion Absolute Navigation System

NASA Technical Reports Server (NTRS)

Holt, Greg N.; Zanetti, Renato; D'Souza, Christopher

2013-01-01

The Orion Multi-Purpose Crew Vehicle (MPCV) is currently under development as NASA's next-generation spacecraft for exploration missions beyond Low Earth Orbit. The MPCV is set to perform an orbital test ight, termed Exploration Flight Test 1 (EFT-1), some time in late 2014. The navigation system for the Orion spacecraft is being designed in a Multi-Organizational Design Environment (MODE) team including contractor and NASA personnel. The system uses an Extended Kalman Filter to process measurements and determine the state. The design of the navigation system has undergone several iterations and modi cations since its inception, and continues as a work-in-progress. This paper seeks to show the e orts made to-date in tuning the lter for the EFT-1 mission and instilling appropriate robustness into the system to meet the requirements of manned space ight. The results generally show Monte Carlo error performance bounded by the lter uncertainty for all phases of ight. Some future items of investigation are presented related to suspected anomalies in the trajectory truth reference le.

40 years of military medical education: an overview of the Long-Term Career Outcome Study (LTCOS).

PubMed

Durning, Steven J; Artino, Anthony R; Dong, Ting; Cruess, David F; Gilliland, William R; DeZee, Kent J; Saguil, Aaron; Waechter, Donna M; McManigle, John E

2012-09-01

In 2005, the Long-Term Career Outcome Study (LTCOS) was established by the Dean, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences (USU). The original charge to the LTCOS team was to establish an electronic database of current and past students at USU. Since its inception, however, the LTCOS team has broadened its mission and started collecting and analyzing data on a continuous basis for the purposes of program evaluation and, in some cases, research. The purpose of this commentary is to review the history of the LTCOS, including details about USU, a brief review of prior LTCOS work, and progress made since our last essay on LTCOS efforts. This commentary also provides an introduction to the special issue, which is arranged as a series of articles that span the medical education continuum (i.e., before, during, and after medical school). The relative balance of articles in each phase of training represents the LTCOS team's efforts to address the entire continuum of medical education.

Analysis of unswept and swept wing chordwise pressure data from an oscillating NACA 0012 airfoil experiment. Volume 1: Technical Report

NASA Technical Reports Server (NTRS)

St.hilaire, A. O.; Carta, F. O.

1983-01-01

The unsteady chordwise force response on the airfoil surface was investigated and its sensitivity to the various system parameters was examined. A further examination of unsteady aerodynamic data on a tunnel spanning wing (both swept and unswept), obtained in a wind tunnel, was performed. The main body of this data analysis was carried out by analyzing the propagation speed of pressure disturbances along the chord and by studying the behavior of the unsteady part of the chordwise pressure distribution at various points of the airfoil pitching cycle. It was found that Mach number effects dominate the approach to and the inception of both static and dynamic stall. The stall angle decreases as the Mach number increases. However, sweep dominates the load behavior within the stall regime. Large phase differences between unswept and swept responses, that do not exist at low lift coefficient, appear once the stall boundary is penetrated. It was also found that reduced frequency is not a reliable indicator of the unsteady aerodynamic response in the high angle of attack regime.

Against the Very Idea of the Politicization of Public Health Policy

PubMed Central

2012-01-01

I criticize the concern over the politicization of public health policy as a justification for preferring a narrow to a broad model of public health. My critique proceeds along 2 lines. First, the fact that administrative structures and actors are primary sources of public health policy demonstrates its inescapably political and politicized nature. Second, historical evidence shows that public health in Great Britain and the United States has from its very inception been political and politicized. I conclude by noting legitimate ethical concerns regarding the political nature of public health policy and argue that open deliberation in a democratic social order is best served by acknowledging the constraints of the inescapably politicized process of public health policymaking. PMID:22095345

The Physics of a Gymnastics Flight Element

NASA Astrophysics Data System (ADS)

Contakos, Jonas; Carlton, Les G.; Thompson, Bruce; Suddaby, Rick

2009-09-01

From its inception, performance in the sport of gymnastics has relied on the laws of physics to create movement patterns and static postures that appear almost impossible. In general, gymnastics is physics in motion and can provide an ideal framework for studying basic human modeling techniques and physical principles. Using low-end technology and basic principles of physics, we analyzed a high-end gymnastics skill competed in by both men and women. The comprehensive goal of the examination is to scientifically understand how a skill of this magnitude is actually physically possible and what must a gymnast do to successfully complete the skill. The examination is divided into three sections, each of which is comprehensive enough to be a separate assignment or small group project.

Battery Technologies for Mass Deployment of Electric Vehicles

DOT National Transportation Integrated Search

2018-03-23

Electric vehicle (EV) batteries have significantly improved since their inception. However, lifetime of these batteries is still strongly dependent on the usage profiles. This report describes aspects of EV battery utilization, and their impact on ba...

Best Practices from WisDOT Mega- and ARRA Projects : Brief

DOT National Transportation Integrated Search

2012-03-01

With the inception of the Marquette Interchange Project in 2004 Wisconsins first ever highway megaproject (over $500 million) WisDOT developed a number of new techniques, methods, processes and procedures for project management. The depart...

12 CFR 616.6300 - Leasing policies, procedures, and underwriting standards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... underwriting requirements in § 614.4150 of this chapter. An institution engaged in the making, buying, or... at the inception of the lease; (b) Process for estimating the leased asset's market value during the...

12 CFR 616.6300 - Leasing policies, procedures, and underwriting standards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... underwriting requirements in § 614.4150 of this chapter. An institution engaged in the making, buying, or... at the inception of the lease; (b) Process for estimating the leased asset's market value during the...

12 CFR 616.6300 - Leasing policies, procedures, and underwriting standards.

Code of Federal Regulations, 2011 CFR

2011-01-01

... underwriting requirements in § 614.4150 of this chapter. An institution engaged in the making, buying, or... at the inception of the lease; (b) Process for estimating the leased asset's market value during the...

75 Years of Physics at NBS

ERIC Educational Resources Information Center

Ambler, Ernest

1976-01-01

This historical survey describes the contributions made to the field of physics by the National Bureau of Standards since its inception in 1901. Four broad areas are emphasized: nuclear physics, thermal physics (including cryogenics), spectroscopy and fundamental constants. (BT)

Special Education: A Microcosm of Bureaucracy. Part Two: The Elements of the System

ERIC Educational Resources Information Center

Clark, Ann D.

1971-01-01

Delineates a case study of special education that provides a unique microcosm of the emergence of an educational subsystem with inherent and forceful bureaucratic controls that were present from its inception. (Author)

Bacterial floc mediated rapid streamer formation in creeping flows

NASA Astrophysics Data System (ADS)

Hassanpourfard, Mahtab; Nikakhtari, Zahra; Ghosh, Ranajay; Das, Siddhartha; Thundat, Thomas; Kumar, Aloke

2015-11-01

One of the contentious problems regarding the interaction of low Reynolds number (Re << 1) fluid flow with bacterial biomass is the formation of filamentous structures called streamers. Recently, we discovered that streamers can be formed from flow-induced deformation of the pre-formed bacterial flocs over extremely small timescales (less than a second). However, these streamers are different than the ones that mediated by biofilms. To optically probe the inception process of these streamers formation, bacterial flocs were embedded with 200 nm red fluorescent polystyrene beads that served as tracers. We also showed that at their inception the deformation of the flocs is dominated by large recoverable strains indicating significant elasticity. These strains subsequently increase tremendously to produce filamentous streamers. At time scales larger than streamers formation time scale, viscous response was observed from streamers. Finally, rapid clogging of microfluidic devices occurred after these streamers formed.

Hydrodynamic cavitation in Stokes flow of anisotropic fluids.

PubMed

Stieger, Tillmann; Agha, Hakam; Schoen, Martin; Mazza, Marco G; Sengupta, Anupam

2017-05-30

Cavitation, the nucleation of vapour in liquids, is ubiquitous in fluid dynamics, and is often implicated in a myriad of industrial and biomedical applications. Although extensively studied in isotropic liquids, corresponding investigations in anisotropic liquids are largely lacking. Here, by combining liquid crystal microfluidic experiments, nonequilibrium molecular dynamics simulations and theoretical arguments, we report flow-induced cavitation in an anisotropic fluid. The cavitation domain nucleates due to sudden pressure drop upon flow past a cylindrical obstacle within a microchannel. For an anisotropic fluid, the inception and growth of the cavitation domain ensued in the Stokes regime, while no cavitation was observed in isotropic liquids flowing under similar hydrodynamic parameters. Using simulations we identify a critical value of the Reynolds number for cavitation inception that scales inversely with the order parameter of the fluid. Strikingly, the critical Reynolds number for anisotropic fluids can be 50% lower than that of isotropic fluids.

Hydrodynamic cavitation in Stokes flow of anisotropic fluids

PubMed Central

Stieger, Tillmann; Agha, Hakam; Schoen, Martin; Mazza, Marco G.; Sengupta, Anupam

2017-01-01

Cavitation, the nucleation of vapour in liquids, is ubiquitous in fluid dynamics, and is often implicated in a myriad of industrial and biomedical applications. Although extensively studied in isotropic liquids, corresponding investigations in anisotropic liquids are largely lacking. Here, by combining liquid crystal microfluidic experiments, nonequilibrium molecular dynamics simulations and theoretical arguments, we report flow-induced cavitation in an anisotropic fluid. The cavitation domain nucleates due to sudden pressure drop upon flow past a cylindrical obstacle within a microchannel. For an anisotropic fluid, the inception and growth of the cavitation domain ensued in the Stokes regime, while no cavitation was observed in isotropic liquids flowing under similar hydrodynamic parameters. Using simulations we identify a critical value of the Reynolds number for cavitation inception that scales inversely with the order parameter of the fluid. Strikingly, the critical Reynolds number for anisotropic fluids can be 50% lower than that of isotropic fluids. PMID:28555615

Leaf LIMS: A Flexible Laboratory Information Management System with a Synthetic Biology Focus.

PubMed

Craig, Thomas; Holland, Richard; D'Amore, Rosalinda; Johnson, James R; McCue, Hannah V; West, Anthony; Zulkower, Valentin; Tekotte, Hille; Cai, Yizhi; Swan, Daniel; Davey, Robert P; Hertz-Fowler, Christiane; Hall, Anthony; Caddick, Mark

2017-12-15

This paper presents Leaf LIMS, a flexible laboratory information management system (LIMS) designed to address the complexity of synthetic biology workflows. At the project's inception there was a lack of a LIMS designed specifically to address synthetic biology processes, with most systems focused on either next generation sequencing or biobanks and clinical sample handling. Leaf LIMS implements integrated project, item, and laboratory stock tracking, offering complete sample and construct genealogy, materials and lot tracking, and modular assay data capture. Hence, it enables highly configurable task-based workflows and supports data capture from project inception to completion. As such, in addition to it supporting synthetic biology it is ideal for many laboratory environments with multiple projects and users. The system is deployed as a web application through Docker and is provided under a permissive MIT license. It is freely available for download at https://leaflims.github.io .

Child- and elder-friendly urban public places in Fatahillah Square Historical District

NASA Astrophysics Data System (ADS)

Srinaga, F.; LKatoppo, M.; Hidayat, J.

2018-03-01

Fatahillah square as an important historical urban square in Jakarta has problems in eye level area integrative processing. Visitors cannot enjoy their time while in the square regarding their visuals, feelings, space, and bodies comfort. These also lead to other problems in which the square is lack of friendly and convenient places for children, the elderly and also the disabled, especially people with limited moving space. The research will attempt in proposing design inception for the Fatahillah Square that is using inclusive user-centered design approach, while in the same time incorporate theoretical studies of children and elderly-design considerations. The first stage of this research was building inclusive design parameter; begin with a context-led research which assesses the quality of Fatahillah square through three basic components of urban space: hardware, software and orgware. The second stage of this research is to propose inclusive design inception for the Fatahillah square.

Hydrodynamic cavitation in Stokes flow of anisotropic fluids

NASA Astrophysics Data System (ADS)

Stieger, Tillmann; Agha, Hakam; Schoen, Martin; Mazza, Marco G.; Sengupta, Anupam

2017-05-01

Cavitation, the nucleation of vapour in liquids, is ubiquitous in fluid dynamics, and is often implicated in a myriad of industrial and biomedical applications. Although extensively studied in isotropic liquids, corresponding investigations in anisotropic liquids are largely lacking. Here, by combining liquid crystal microfluidic experiments, nonequilibrium molecular dynamics simulations and theoretical arguments, we report flow-induced cavitation in an anisotropic fluid. The cavitation domain nucleates due to sudden pressure drop upon flow past a cylindrical obstacle within a microchannel. For an anisotropic fluid, the inception and growth of the cavitation domain ensued in the Stokes regime, while no cavitation was observed in isotropic liquids flowing under similar hydrodynamic parameters. Using simulations we identify a critical value of the Reynolds number for cavitation inception that scales inversely with the order parameter of the fluid. Strikingly, the critical Reynolds number for anisotropic fluids can be 50% lower than that of isotropic fluids.

A micropalaeontological perspective on export productivity, oxygenation and temperature in NE Atlantic deep-waters across Terminations I and II

NASA Astrophysics Data System (ADS)

Grunert, Patrick; Skinner, Luke; Hodell, David A.; Piller, Werner E.

2015-08-01

Census counts of benthic foraminifera were studied from the SW Iberian Margin to reconstruct past changes in deep-water hydrography across Terminations I and II. Detailed benthic faunal data (> 125 μm size-fraction) allow us to evaluate the limitations imposed by taphonomic processes and restricted size-fractions. The comparison of recent (mudline) and fossil assemblages at IODP Site U1385 indicates the quick post-mortem disintegration of shells of astrorhizoid taxa (~ 80% of the present-day fauna), resulting in impoverished fossil assemblages. While the application of quantitative proxy methods is problematic under these circumstances, the fossil assemblages can still provide a qualitative palaeoenvironmental signal that, while most fully expressed in the 125-212 μm size-fraction, is nonetheless also expressed to some degree in the > 212 μm size-fraction. Variations in the benthic foraminiferal assemblages reveal information about changing organic matter supply, deep-water oxygenation and temperature. MIS 2 is generally characterized by an elevated trophic state and variable oxic conditions, with oxygenation minima culminating in the Younger Dryas (YD) and Heinrich Stadials (HS) 1, 2 and 3. Low oxic conditions coincide with decreased water-temperature and lower benthic δ13C, pointing to the strong influence of a southern sourced water-mass during these periods. HS 1 is the most extreme of these intervals, providing further evidence for a severe temporary reduction or even shutdown of AMOC. With the inception of MIS 1, organic matter supply reduced and a better ventilated deep-water environment bathed by NEADW is established. For Termination II, clear indications of southern-sourced water are limited to the early phase of HS 11. During the latter part of HS 11, the deep-water environment seems to be determined by strongly increased supply of organic matter, potentially explaining the decoupling of benthic δ13C and Mg/Ca records of earlier studies as a phytodetritus effect on the carbon isotope signal. However, the presence of a warm, nutrient-rich and poorly oxygenated water-mass cannot be ruled out. With the inception of interglacial MIS 5e trophic conditions are reduced and ventilation by NEADW increases.

Computation and modeling of aero-thermal fields in turbine cascades and strongly curved ducts

NASA Technical Reports Server (NTRS)

Luo, J.; Lakshminarayana, B.

1994-01-01

Advanced turbulence models are crucial for accurate prediction of rocket engine flows, due to existence of very large extra strain rates, such as strong streamline curvature. Numerical simulation of the turbulent flow in a strongly curved turn-around duct (TAD) has been carried out with a Reynolds stress model (RSM), an algebraic Reynolds stress model (ARSM) and a kappa-epsilon model. the RSM model and the ARSM model are found to capture the turbulence damping due to the convex curvature, but underpredict the turbulence enhancement caused by the concave curvature. To capture the concave curvature effects, it is necessary to modify the epsilon-equation. The modification of episilon-equation suggested by Launder, et.al, provides the correct trend, but over-corrects the curvature effects. A comparative study of two modes of transition in gas turbine, the by-pass transition and the separation-induced transition, has been carried out with several low-Reynolds-number (LRN) kappa-epsilon models. Effects of blade surface pressure gradient, freestream turbulence and Reynolds number on the blade boundary layer development, and particularly the inception of transition are examined in detail. The present study indicates that the turbine blade transition, in the presence of high freestream turbulence, is predicted well with LRN kappa-epsilon models employed.

A new concept for glacial geological investigations of surges, based on High-Arctic examples (Svalbard)

NASA Astrophysics Data System (ADS)

Lønne, Ida

2016-01-01

Svalbard is a key area for the investigation of glacial surges, and almost two centuries worth of field observations exists from this region. Studies have shown that the course of a surge and the associated formation of landforms are strongly influenced by basinal factors, and that the broad range of variables involved can hamper interpretations and comparisons. Based on a review of surges in Svalbard, a new concept for glacial geological investigations has been developed that combines ice-flows, ice-front movements, and morphostratigraphy. The concept is comprised of the following four elements: 1) classification based on the configuration and characteristics of the receiving basin, 2) division of the surge cycle into six stages, 3) guidelines for morphological mapping, and 4) use of an allostratigraphic approach for interpreting ice-front movements. In this context, delineation of the active phase is critical, which include the history of terminus movements, and four main categories of receiving basins are recognized. These are (A) terrestrial basins with deformable substrates, (B) terrestrial basins with poorly deformable substrates, (C) shallow water basins, and (D) deep water basins. The ice-front movement history is reconstructed by coupling information from the proglacial moraines (syn-surge), the supraglacial moraines (post-surge), and the associated traces of meltwater to the surge stages (I-VI). This approach has revealed a critical relationship between the termination of the active phase and three morphological elements, namely, the maximum ice-front position, the maximum moraine extent and the youngest proglacial moraine, which are unique for each of the basins A-D. The concept is thus a novel and more precise approach for mapping the active phase and the active phase duration, as shown by the ∼12-year long surge of Fridtjovbreen, where stage I was 30 months (inception), stage II was 54 months (ice-front advance), stage III was 12 months (stillstand), and stage IV was 48 months (retreat during active flow). The glacier has been in quiescent phase (stages V/VI) since 2002.

Organization's Orderly Interest Exploration: Inception, Development and Insights of AIAA's Topics Database

NASA Technical Reports Server (NTRS)

Marshall, Jospeh R.; Morris, Allan T.

2007-01-01

Since 2003, AIAA's Computer Systems and Software Systems Technical Committees (TCs) have developed a database that aids technical committee management to map technical topics to their members. This Topics/Interest (T/I) database grew out of a collection of charts and spreadsheets maintained by the TCs. Since its inception, the tool has evolved into a multi-dimensional database whose dimensions include the importance, interest and expertise of TC members and whether or not a member and/or a TC is actively involved with the topic. In 2005, the database was expanded to include the TCs in AIAA s Information Systems Group and then expanded further to include all AIAA TCs. It was field tested at an AIAA Technical Activities Committee (TAC) Workshop in early 2006 through live access by over 80 users. Through the use of the topics database, TC and program committee (PC) members can accomplish relevant tasks such as: to identify topic experts (for Aerospace America articles or external contacts), to determine the interest of its members, to identify overlapping topics between diverse TCs and PCs, to guide new member drives and to reveal emerging topics. This paper will describe the origins, inception, initial development, field test and current version of the tool as well as elucidate the benefits and insights gained by using the database to aid the management of various TC functions. Suggestions will be provided to guide future development of the database for the purpose of providing dynamics and system level benefits to AIAA that currently do not exist in any technical organization.

Nucleate pool boiling in the long duration low gravity environment of the space shuttle

NASA Technical Reports Server (NTRS)

Hasan, M. M.; Lin, C. S.; Knoll, R. H.; Bentz, M. D.; Meserole, J. S.

1993-01-01

The results are presented of an experimental study of nucleate pool boiling performed in the low gravity environment of the space shuttle. Photographic observations of pool boiling in Freon 113 were obtained during the 'Tank Pressure Control Experiment', flown on the Space Transportation System STS-43 in August 1991. Nucleate boiling data from large (relative to bubble size) flat heating surfaces (0.1046 by 0.0742 m) was obtained at very low heat fluxes (0.22 to 1.19 kw/so m). The system pressure and the bulk liquid subcooling varied in the range of 40 to 60 kPa and 3 to 5 C respectively. Thirty-eight boiling tests, each of 10 min duration for a given heat flux, were conducted. Measurements included the heater power, heater surface temperature, the liquid temperature and the system pressure as functions of heating time. Video data of the first 2 min of heating was recorded for each test. In some tests the video clearly shows the inception of boiling and the growth and departure of bubbles from the surface during the first 2 min of heating. In the absence of video data, the heater temperature variation during heating shows the inception of boiling and stable nucleate boiling. During the stable nucleate boiling, the wall superheat varied between 2.8 to 3.8 C for heat fluxes in the range of 0.95 to 1.19 kw/so m. The wall superheat at the inception of boiling varied between 2 to 13 C.

Nucleate pool boiling in the long duration low gravity environment of the Space Shuttle

NASA Technical Reports Server (NTRS)

Hasan, M. M.; Lin, C. S.; Knoll, R. H.; Bentz, M. D.; Meserole, J. S.

1993-01-01

The results are presented of an experimental study of nucleate pool boiling performed in the low gravity environment of the space shuttle. Photographic observations of pool boiling in Freon 113 were obtained during the 'Tank Pressure Control Experiment,' flown on the Space Transportation System, STS-43 in August 1991. Nucleate boiling data from large (relative to bubble size) flat heating surfaces (0.1046 by 0.0742 m) was obtained at very low heat fluxes (0.22 to 1.19 kW/sq m). The system pressure and the bulk liquid subcooling varied in the range of 40 to 60 kPa and 3 to 5 C respectively. Thirty-eight boiling tests, each of 10-min duration for a given heat flux, were conducted. Measurements included the heater power, heater surface temperature, the liquid temperature and the system pressure as functions of heating time. Video data of the first 2 min of heating was recorded for each test. In some tests the video clearly shows the inception of boiling and the growth and departure of bubbles from the surface during the first 2 min of heating. In the absence of video data, the heater temperature variation during heating shows the inception of boiling and stable nucleate boiling. During the stable nucleate boiling, the wall superheat varied between 2.8 to 3.8 C for heat fluxes in the range of 0.95 to 1.19 kW/sq m. The wall superheat at the inception of boiling varied between 2 to 13 C.

Potential for treatment of severe autism in tuberous sclerosis complex

PubMed Central

Gipson, Tanjala T; Gerner, Gwendolyn; Wilson, Mary Ann; Blue, Mary E; Johnston, Michael V

2013-01-01

The Food and Drug Administration (FDA) has approved two mechanism-based treatments for tuberous sclerosis complex (TSC)-everolimus and vigabatrin. However, these treatments have not been systematically studied in individuals with TSC and severe autism. The aim of this review is to identify the clinical features of severe autism in TSC, applicable preclinical models, and potential barriers that may warrant strategic planning in the design phase of clinical trial development. A comprehensive search strategy was formed and searched across PubMed, Embase and SCOPUS from their inception to 2/21/12, 3/16/12, and 3/12/12 respectively. After the final search date, relevant, updated articles were selected from PubMed abstracts generated electronically and emailed daily from PubMed. The references of selected articles were searched, and relevant articles were selected. A search of clinicaltrials.gov was completed using the search term “TSC” and “tuberous sclerosis complex”. Autism has been reported in as many as 60% of individuals with TSC; however, review of the literature revealed few data to support clear classification of the severity of autism in TSC. Variability was identified in the diagnostic approach, assessment of cognition, and functional outcome among the reviewed studies and case reports. Objective outcome measures were not used in many early studies; however, diffusion tensor imaging of white matter, neurophysiologic variability in infantile spasms, and cortical tuber subcategories were examined in recent studies and may be useful for objective classification of TSC in future studies. Mechanism-based treatments for TSC are currently available. However, this literature review revealed two potential barriers to successful design and implementation of clinical trials in individuals with severe autism-an unclear definition of the population and lack of validated outcome measures. Recent studies of objective outcome measures in TSC and further study of applicable preclinical models present an opportunity to overcome these barriers. PMID:25254170

Efficacy and safety of selective glucocorticoid receptor modulators in comparison to glucocorticoids in arthritis, a systematic review.

PubMed

Safy, M; de Hair, M J H; Jacobs, J W G; Buttgereit, F; Kraan, M C; van Laar, J M

2017-01-01

Long-term treatment with glucocorticoids (GCs) plays an important role in the management of arthritis patients, although the efficacy/safety balance is unfavorable. Alternatives with less (severe) adverse effects but with good efficacy are needed. Selective GC receptor modulators (SGRMs) are designed to engage the GC receptor with dissociative characteristics: transactivation of genes, which is mainly responsible for unwanted effects, is less strong while trans-repression of genes, reducing inflammation, is maintained. It is expected that SGRMs thus have a better efficacy/safety balance than GCs. A systematic review providing an overview of the evidence in arthritis is lacking. To systematically review the current literature on efficacy and safety of oral SGRMs in comparison to GCs in arthritis. A search was performed in Medline, Embase and the Cochrane Library, from inception dates of databases until May 2017. Experimental studies involving animal arthritis models or human material of arthritis patients, as well as clinical studies in arthritis patients were included, provided they reported original data. All types of arthritis were included. Data was extracted on the SGRM studied and on the GC used as reference standard; the design or setting of the study was extracted as well as the efficacy and safety results. A total of 207 articles was retrieved of which 17 articles were eligible for our analysis. Two studies concerned randomized controlled trials (RCT), five studies were pre-clinical studies using human material, and 10 studies involved pre-clinical animal models (acute and/or chronic arthritis induced in mice or rats). PF-04171327, the only compound investigated in a clinical trial setting, had a better efficacy/safety balance compared to GCs: better clinical anti-inflammatory efficacy and similar safety. Studies assessing both efficacy and safety of SGRMs are scarce. There is limited evidence for dissociation of anti-inflammatory and metabolic effects of the SGRMs studied. Development of many SGRMs is haltered in a preclinical phase. One SGRM showed a better clinical efficacy/safety balance.

Identifying and understanding the concerns of business: a systematic approach to the development of the Australian WorkHealth Program - Arthritis.

PubMed

Reavley, Nicola; Livingston, Jenni; Buchbinder, Rachelle; Osborne, Richard

2012-07-01

The aim of the Australian WorkHealth Program - Arthritis was to develop and test an education program designed to minimise risk of arthritis and prevent or reduce absenteeism and presenteeism. The objective of the current study was to use a wide-ranging, multifaceted and interactive approach to engage with stakeholders in order to inform the content and delivery of the intervention. Methods used to inform program design included a concept mapping workshop, interviews, surveys, a steering committee and an industry advisory group. Engaging with a wide range of stakeholders in multiple ways early in program development allowed for the comparison and verification of data to obtain a better overall picture of the needs of participants. It also offered the opportunity to share 'ownership' of the program with stakeholders by generating a program that was tailored to their ethos and needs. The stakeholder engagement process was instrumental in building commitment to the program and establishing an overarching model of action. Interview and survey data indicated that awareness of arthritis was low and musculoskeletal disorders more generally were of greater concern. It was agreed that programs should be relevant, evidence-based, involve senior management education, incorporate a business case, and involve tailored implementation and marketing strategies. The qualitative preparatory phase as well as all the engagement work was key to informing program design. The approach taken in this study has the potential to inform a wide range of workplace interventions. Engaging with a wide range of stakeholders in multiple ways from program inception allowed for the comparison and verification of information to permit the generation of a model of intervention that had the highest possible chance of success. It offered the opportunity to not only define program content and implementation processes, but to build genuine 'ownership' of the program.

North American trade growth continued in 2007

DOT National Transportation Integrated Search

2009-02-01

Trade between the United States and : its North American Free Trade Agreement : (NAFTA) partnersCanada : and Mexicohas more than doubled : in dollar value since the inception of : NAFTA in 1994. In 2007, U.S. trade : with Canada and Mexico reac...

Field, Formon, Superspace, and Inceptive Cyborg: A Paraphysical Theory of Noncausal Phenomena

DTIC Science & Technology

1974-12-01

Mikhailova is able to accomplish psychokinesis;*^ psychic healing can indeed be accomplished; telepathy and clairvoyance can be accomplished even in a...passes extrasensory perception, telekinesis, teleportation, firewalking, acupuncture, psychic phenomena, telepathy , clair- voyance, psionlc

Leading articles in medical journals in 1966.

PubMed

Stimpson, Philippa J; Marks, Daniel Jb

2016-10-01

The British Journal of Hospital Medicine is 50 years old. This article takes a look back at articles published during the year of its inception from the British Medical Journal, the Lancet and the Journal of the American Medical Association.

Digitizing Some Keywords.

ERIC Educational Resources Information Center

Lanham, Richard A.

1989-01-01

Traces the early history of the electronic digital computer and the viewpoints held concerning the computer from its inception to its present status. Highlights three key words ("mimesis,""topic," and "decorum") to develop the rhetoricality of the personal computer as a communications device. (KEH)

Dance Theatre of Harlem: Inspiring the Deprived

ERIC Educational Resources Information Center

Weil, Henry

1976-01-01

The Dance Theatre of Harlem, which includes both a school and a publicly performing dance company, is described from its inception by its artistic director, Arthur Mitchell, to its current activities. Budgets, student characteristics, and philosophy are discussed. (LBH)

Advanced Traveler Information Systems (ATIS) 2.0 Precursor System: Final Report

DOT National Transportation Integrated Search

2018-03-01

Advanced Traveler Information Systems (ATIS) have experienced significant growth since their initial inception in the 1990s. Technologies have continued to evolve at a rapid pace, enabling the integration of advanced solutions for traveler informatio...

NASA compendium of satellite communications programs

NASA Technical Reports Server (NTRS)

1971-01-01

A comprehensive review of worldwide satellite communication programs is reported that ranges in time from the inception of satellite communications to mid-1971. Particular emphasis is placed on program results, including experiments conducted, communications system operational performance, and technology employed.

Variable dynamic testbed vehicle : safety plan

DOT National Transportation Integrated Search

1997-02-01

This safety document covers the entire safety process from inception to delivery of the Variable Dynamic Testbed Vehicle. In addition to addressing the process of safety on the vehicle , it should provide a basis on which to build future safety proce...

Risk factors for persistent problems following acute whiplash injury: update of a systematic review and meta-analysis.

PubMed

Walton, David M; Macdermid, Joy C; Giorgianni, Anthony A; Mascarenhas, Joanna C; West, Stephen C; Zammit, Caroline A

2013-02-01

Systematic review and meta-analysis. To update a previous review and meta-analysis on risk factors for persistent problems following whiplash secondary to a motor vehicle accident. Prognosis in whiplash-associated disorder (WAD) has become an active area of research, perhaps owing to the difficulty of treating chronic problems. A previously published review and meta-analysis of prognostic factors included primary sources up to May 2007. Since that time, more research has become available, and an update to that original review is warranted. A systematic search of international databases was conducted, with rigorous inclusion criteria focusing on studies published between May 2007 and May 2012. Articles were scored, and data were extracted and pooled to estimate the odds ratio for any factor that had at least 3 independent data points in the literature. Four new cohorts (n = 1121) were identified. In combination with findings of a previous review, 12 variables were found to be significant predictors of poor outcome following whiplash, 9 of which were new (n = 2) or revised (n = 7) as a result of additional data. The significant variables included high baseline pain intensity (greater than 5.5/10), report of headache at inception, less than postsecondary education, no seatbelt in use during the accident, report of low back pain at inception, high Neck Disability Index score (greater than 14.5/50), preinjury neck pain, report of neck pain at inception (regardless of intensity), high catastrophizing, female sex, WAD grade 2 or 3, and WAD grade 3 alone. Those variables robust to publication bias included high pain intensity, female sex, report of headache at inception, less than postsecondary education, high Neck Disability Index score, and WAD grade 2 or 3. Three existing variables (preaccident history of headache, rear-end collision, older age) and 1 additional novel variable (collision severity) were refined or added in this updated review but showed no significant predictive value. This review identified 2 additional prognostic factors and refined the estimates of 7 previously identified factors, bringing the total number of significant predictors across the 2 reviews to 12. These factors can be easily identified in a clinical setting to provide estimates of prognosis following whiplash.

High-level PC-based laser system modeling

NASA Astrophysics Data System (ADS)

Taylor, Michael S.

1991-05-01

Since the inception of the Strategic Defense Initiative (SDI) there have been a multitude of comparison studies done in an attempt to evaluate the effectiveness and relative sizes of complementary, and sometimes competitive, laser weapon systems. It became more and more apparent that what the systems analyst needed was not only a fast, but a cost effective way to perform high-level trade studies. In the present investigation, a general procedure is presented for the development of PC-based algorithmic systems models for laser systems. This procedure points out all of the major issues that should be addressed in the design and development of such a model. Issues addressed include defining the problem to be modeled, defining a strategy for development, and finally, effective use of the model once developed. Being a general procedure, it will allow a systems analyst to develop a model to meet specific needs. To illustrate this method of model development, a description of the Strategic Defense Simulation - Design To (SDS-DT) model developed and used by Science Applications International Corporation (SAIC) is presented. SDS-DT is a menu-driven, fast executing, PC-based program that can be used to either calculate performance, weight, volume, and cost values for a particular design or, alternatively, to run parametrics on particular system parameters to perhaps optimize a design.

Treatment Effects of Removable Functional Appliances in Pre-Pubertal and Pubertal Class II Patients: A Systematic Review and Meta-Analysis of Controlled Studies

PubMed Central

Perinetti, Giuseppe; Primožič, Jasmina; Franchi, Lorenzo; Contardo, Luca

2015-01-01

Background Treatment effects of removable functional appliances in Class II malocclusion patients according to the pre-pubertal or pubertal growth phase has yet to be clarified. Objectives To assess and compare skeletal and dentoalveolar effects of removable functional appliances in Class II malocclusion treatment between pre-pubertal and pubertal patients. Search methods Literature survey using the Medline, SCOPUS, LILACS and SciELO databases, the Cochrane Library from inception to May 31, 2015. A manual search was also performed. Selection criteria Randomised (RCTs) or controlled clinical trials with a matched untreated control group. No restrictions were set regarding the type of removable appliance whenever used alone. Data collection and analysis For the meta-analysis, cephalometric parameters on the supplementary mandibular growth were the main outcomes, with other cephalometric parameters considered as secondary outcomes. Risk of bias in individual and across studies were evaluated along with sensitivity analysis for low quality studies. Mean differences and 95% confidence intervals for annualised changes were computed according to a random model. Differences between pre-pubertal and pubertal patients were assessed by subgroup analyses. GRADE assessment was performed for the main outcomes. Results Twelve articles (but only 3 RCTs) were included accounting for 8 pre-pubertal and 7 pubertal groups. Overall supplementary total mandibular length and mandibular ramus height were 0.95 mm (0.38, 1.51) and 0.00 mm (-0.52, 0.53) for pre-pubertal patients and 2.91 mm (2.04, 3.79) and 2.18 mm (1.51, 2.86) for pubertal patients, respectively. The subgroup difference was significant for both parameters (p<0.001). No maxillary growth restrain or increase in facial divergence was seen in either subgroup. The GRADE assessment was low for the pre-pubertal patients, and generally moderate for the pubertal patients. Conclusions Taking into account the limited quality and heterogeneity of the included studies, functional treatment by removable appliances may be effective in treating Class II malocclusion with clinically relevant skeletal effects if performed during the pubertal growth phase. PMID:26510187

Shear wave velocity structure in the lithosphere and asthenosphere across the Southern California continent and Pacific plate margin using inversion of Rayleigh wave data from the ALBACORE project.

NASA Astrophysics Data System (ADS)

Price, A. C.; Weeraratne, D. S.; Kohler, M. D.; Rathnayaka, S.; Escobar, L., Sr.

2015-12-01

The North American and Pacific plate boundary is a unique example of past subduction of an oceanic spreading center which has involved oceanic plate capture and inception of a continental transform boundary that juxtaposes continental and oceanic lithosphere on a single plate. The amphibious ALBACORE seismic project (Asthenospheric and Lithospheric Broadband Architecture from the California Offshore Region Experiment) deployed 34 ocean bottom seismometers (OBS) on 15-35 Ma seafloor and offers a unique opportunity to compare the LAB in continental and oceanic lithosphere in one seismic study. Rayleigh waves were recorded simultaneously by our offshore array and 82 CISN network land stations from 2010-2011. Here we predict phase velocities for a starting shear wave velocity model for each of 5 regions in our study area and compare to observed phase velocities from our array in a least-squares sense that produces the best fit 1-D shear wave velocity structure for each region. Preliminary results for the deep ocean (seafloor 25-32 Ma) indicates high velocities reaching 4.5 km/s at depths of 50 km associated with the lithosphere for seafloor 25-32 Ma. A negative velocity gradient is observed below this which reaches a minimum of 4.0 km/s at 160 km depth. The mid-ocean region (age 13-25 Ma) indicates a slightly lower magnitude and shallower LVZ. The Inner Borderland displays the highest lithospheric velocities offshore reaching 4.8 km/s at 40 km depth indicating underplating. The base of the LVZ in the Borderland increases sharply from 4.0 km/s to 4.5 km/s at 80-150 km depth indicating partial melt and compositional changes. The LVZ displays a very gradual positive velocity gradient in all other regions such as the deep seafloor and continent reaching 4.5 km/s at 300 km depth. The deep ocean, Borderlands, and continental region each have unique lithospheric velocities, LAB depths, and LVZ character that indicate stark differences in mantle structure that occur on a single plate as well as across the continental margin.

Adolescent brain development in normality and psychopathology

PubMed Central

LUCIANA, MONICA

2014-01-01

Since this journal’s inception, the field of adolescent brain development has flourished, as researchers have investigated the underpinnings of adolescent risk-taking behaviors. Explanations based on translational models initially attributed such behaviors to executive control deficiencies and poor frontal lobe function. This conclusion was bolstered by evidence that the prefrontal cortex and its interconnections are among the last brain regions to structurally and functionally mature. As substantial heterogeneity of prefrontal function was revealed, applications of neuroeconomic theory to adolescent development led to dual systems models of behavior. Current epidemiological trends, behavioral observations, and functional magnetic resonance imaging based brain activity patterns suggest a quadratic increase in limbically mediated incentive motivation from childhood to adolescence and a decline thereafter. This elevation occurs in the context of immature prefrontal function, so motivational strivings may be difficult to regulate. Theoretical models explain this patterning through brain-based accounts of subcortical–cortical integration, puberty-based models of adolescent sensation seeking, and neurochemical dynamics. Empirically sound tests of these mechanisms, as well as investigations of biology–context interactions, represent the field’s most challenging future goals, so that applications to psychopathology can be refined and so that developmental cascades that incorporate neurobiological variables can be modeled. PMID:24342843

Adolescent brain development in normality and psychopathology.

PubMed

Luciana, Monica

2013-11-01

Since this journal's inception, the field of adolescent brain development has flourished, as researchers have investigated the underpinnings of adolescent risk-taking behaviors. Explanations based on translational models initially attributed such behaviors to executive control deficiencies and poor frontal lobe function. This conclusion was bolstered by evidence that the prefrontal cortex and its interconnections are among the last brain regions to structurally and functionally mature. As substantial heterogeneity of prefrontal function was revealed, applications of neuroeconomic theory to adolescent development led to dual systems models of behavior. Current epidemiological trends, behavioral observations, and functional magnetic resonance imaging based brain activity patterns suggest a quadratic increase in limbically mediated incentive motivation from childhood to adolescence and a decline thereafter. This elevation occurs in the context of immature prefrontal function, so motivational strivings may be difficult to regulate. Theoretical models explain this patterning through brain-based accounts of subcortical-cortical integration, puberty-based models of adolescent sensation seeking, and neurochemical dynamics. Empirically sound tests of these mechanisms, as well as investigations of biology-context interactions, represent the field's most challenging future goals, so that applications to psychopathology can be refined and so that developmental cascades that incorporate neurobiological variables can be modeled.

Composite load spectra for select space propulsion structural components

NASA Technical Reports Server (NTRS)

Newell, J. F.; Kurth, R. E.; Ho, H.

1986-01-01

A multiyear program is performed with the objective to develop generic load models with multiple levels of progressive sophistication to simulate the composite (combined) load spectra that are induced in space propulsion system components, representative of Space Shuttle Main Engines (SSME), such as transfer ducts, turbine blades, and liquid oxygen (LOX) posts. Progress of the first year's effort includes completion of a sufficient portion of each task -- probabilistic models, code development, validation, and an initial operational code. This code has from its inception an expert system philosophy that could be added to throughout the program and in the future. The initial operational code is only applicable to turbine blade type loadings. The probabilistic model included in the operational code has fitting routines for loads that utilize a modified Discrete Probabilistic Distribution termed RASCAL, a barrier crossing method and a Monte Carlo method. An initial load model was developed by Battelle that is currently used for the slowly varying duty cycle type loading. The intent is to use the model and related codes essentially in the current form for all loads that are based on measured or calculated data that have followed a slowly varying profile.

Task II: Three-dimensional Rotating Stall Inception and Effects of Rotating Tip Clearance Asymmetry in Axial Compressors

NASA Technical Reports Server (NTRS)

Suder, Kenneth (Technical Monitor); Tan, Choon-Sooi

2003-01-01

The effects of two types of flow non-uniformity on stall inception behavior were assessed with linearized stability analyses of two compressor flow models. Response to rotating tip clearance asymmetries induced by a whirling rotor shaft or rotor height variations were investigated with a two-dimensional flow model. A 3-D compressor model was also developed to study the stability of both full-span and part-span rotating stall modes in annular geometries with radial flow variations. The studies focussed on (1) understanding what compressor designs were sensitive to these types of circumferential and spanwise flow non-uniformities, and (2) situations where 2-D stability theories were inadequate because of 3-D flow effects. Rotating tip clearance non-uniformity caused the greatest performance loss for shafts whirling at the rotating stall frequency. A whirling shaft displacement of 1 percent chord caused the stalling mass flow to rise by as much as 10 percent and the peak pressure rise to decrease by 6 percent. These changes were an order of magnitude larger than for equivalent-sized stationary or rotor-locked clearance asymmetries. Spanwise flow non-uniformity always destabilized the compressor, so that 2-D models over-predicted that stall margin compared to 3-D theory. The difference increased for compressors with larger spanwise variations of characteristic slope and reduced characteristic curvature near the peak. Differences between 2-D and 3-D stall point predictions were generally unacceptable (2 - 4 percent of flow coefficient) for single-stage configurations, but were less than 1 percent for multistage compressors. 2-D analyses predicted the wrong stall mode for specific cases of radial inlet flow distortion, mismatching and annulus area contraction, where higher-order radial modes led to stall. The stability behavior of flows with circumferential or radial non-uniformity was unified through a single stability criterion. The stall point for both cases was set by the integral around the annulus of the pressure rise characteristic slope, weighted by the amplitude of the mode shape. For the case of steady circumferential variations, this criterion reduced to the integrated mean slope (IMS) condition associated with steady inlet distortions. The rotating tip clearance asymmetry model was also used to demonstrate the feasibility of actively controlling the shaft position to suppress rotating stall. In axisymmetric mean flow, this method only stabilized the first harmonic mode, increasing the operating range until surge or higher harmonic modes became unstable.

Athletics Reform and Faculty Perceptions

ERIC Educational Resources Information Center

Lawrence, Janet; Ott, Molly; Hendricks, Lori

2009-01-01

Since their inception, intercollegiate athletics have engendered controversy and stimulated debate. Supporters assert that "college sports are significant in defining the essence of the American college and university", suggesting that benefits associated with athletics include more increased fundraising, positive public perceptions of graduates,…

Comprehensive metabolomic profiling and incident cardiovascular disease: a systematic review

USDA-ARS?s Scientific Manuscript database

Background: Metabolomics is a promising tool of cardiovascular biomarker discovery. We systematically reviewed the literature on comprehensive metabolomic profiling in association with incident cardiovascular disease (CVD). Methods and Results: We searched MEDLINE and EMBASE from inception to Janua...

Long-term trends in patron satisfaction of DC Circulator.

DOT National Transportation Integrated Search

2013-10-01

The DC Circulator is a local transit system designed to facilitate travel to and within the central business area in the District of Columbia. Since its inception in 2005, the Downtown DC Business Improvement District (DCBID) and the District Departm...

THE MID-ATLANTIC INTEGRATED ASSESSMENT (MAIA)

EPA Science Inventory

Since its inception, EPA has focused its research and monitoring towards its regulatory requirements?to protect air and water quality, to control the use of pesticides and toxic substances, to ensure the safe production, handling, and disposal of industrial chemicals, and to clea...

Evidence of Effectiveness

ERIC Educational Resources Information Center

Slabine, Nancy Ames

2011-01-01

Since its inception, Learning Forward has provided members with informative, interactive annual conferences, institutes, and other learning programs; research-based and user-friendly publications; and opportunities for professional networking at national, regional, and state levels. Its new name reflects the fact that the organization has grown…

Surviving your first OSHA inspection.

PubMed

Coughlin, L; Jukkala, P

1994-05-01

With the inception of the bloodborne pathogens standard, home care agencies are more likely to undergo an inspection by the Occupational Safety and Health Administration. What should employers know, and how can they always be prepared for the startling announcement of an OSHA inspection?

The Inception of a Mathematical Autobiography.

ERIC Educational Resources Information Center

Lee, Fong-Yun; Silverman, Fredrick L.; Leali, Shirley A.

1996-01-01

Describes a mathematical autobiography as a written history of a person's journey of learning and using mathematics either in or out of the classroom setting. Explores the idea of using mathematics autobiographies to enhance student learning in mathematics. (Contains 11 references). (ASK)

Prevention of derailments due to concrete tie rail seat deterioration

DOT National Transportation Integrated Search

2007-03-13

Concrete tie rail seat abrasion/deterioration (RSA) has : been an issue since the inception of concrete ties. As a : result of recent derailments involving abraded concrete : ties on curved track, the Federal Railroad Administration : set up a task f...

GEOINFORMATION AND REGIONAL VULNERABILITY ASSESSMENT (REVA)

EPA Science Inventory

Since its inception in 1970, the United States Environmental Protection Agency (EPA) has monitored air, water, land and human health. Currently, EPA's mission is centered on a set five goals: Clean Air, Clean Water, Land Preservation, Healthy Communities, and Stewardship. As pa...

U.S. EPA'S RESEARCH ON LIFE-CYCLE ANALYSIS

EPA Science Inventory

Life-cycle analysis (LCA) consists of looking at a product, process or activity from its inception through its completion. or consumer products, this includes the stages of raw material acquisition, manufacturing and fabrication, distribution, consumer use/reuse and final disposa...

Transit System Map Evaluation : Final Report

DOT National Transportation Integrated Search

1983-09-12

With its first issue in January 1981, production and distribution of the WMATA Transit System Map has been assigned to the Office of Marketing. Since the inception of the program, approximately 250,000 copies of the System Map have been distributed t...

NASA Compendium of Satellite Communications Programs

NASA Technical Reports Server (NTRS)

1973-01-01

A comprehensive review is presented of worldwide communication programs that range in time from the inception of satellite communications to August 1971. The programs included are: Echo, Courier, West Ford, Telstar, Relay, Syncom, Lincoln experimental satellites, Intelsat, Tacsat, Skynet, Nato system, and Telesat.

ASSESSMENT OF COLD-CLIMATE ENVIRONMENTAL RESEARCH PRIORITIES

EPA Science Inventory

Since its inception, the U.S. Environmental Protection Agency has maintained a research program in Alaska to address environmental problems unique to cold climates. The wide range of natural resource developments now being considered pose an equally wide range of possible environ...

Health Assessment Questionnaire disability progression in early rheumatoid arthritis: Systematic review and analysis of two inception cohorts

PubMed Central

Norton, Sam; Fu, Bo; Scott, David L.; Deighton, Chris; Symmons, Deborah P.M.; Wailoo, Allan J.; Tosh, Jonathan; Lunt, Mark; Davies, Rebecca; Young, Adam; Verstappen, Suzanne M.M

2014-01-01

Objective The Health Assessment Questionnaire is widely used for patients with inflammatory polyarthritis (IP) and its subset, rheumatoid arthritis (RA). In this study, we evaluated the progression of HAQ scores in RA (i) by systematically reviewing the published literature on the methods used to assess changes in functional disability over time and (ii) to study in detail HAQ progression in two large prospective observational studies from the UK. Methods Data from two large inception cohorts, ERAS and NOAR, were studied to determine trajectories of HAQ progression over time by applying latent class growth models (LCGMs) to each dataset separately. Age, sex, baseline DAS28, symptom duration, rheumatoid factor, fulfilment of the 1987 ACR criteria and socio-economic status (SES) were included as potential predictors of HAQ trajectory subgroup membership. Results The literature search identified 49 studies showing that HAQ progression has mainly been based on average changes in the total study population. In the HAQ progression study, a LCGM with four HAQ trajectory subgroups was selected as providing the best fit in both cohorts. In both the cohorts, older age, female sex, longer symptom duration, fulfilment of the 1987 ACR criteria, higher DAS28 and lower SES were associated with increased likelihood of membership of subgroups with worse HAQ progression. Conclusion Four distinct HAQ trajectory subgroups were derived from the ERAS and NOAR cohorts. The fact that the subgroups identified were nearly identical supports their validity. Identifying distinct groups of patients who are at risk of poor functional outcome may help to target therapy to those who are most likely to benefit. PMID:24925692

The Neutral Gas Desorption and Breakdown on a Metal-Dielectric Junction Immersed in a Plasma

NASA Technical Reports Server (NTRS)

Vayner, Boris; Galofaro, Joel; Ferguson, Dale; Lyons, Valerie J. (Technical Monitor)

2002-01-01

New results are presented of an experimental study and theoretical analysis of arcing on metal-dielectric junctions immersed in a low-density plasma. Two samples of conventional solar arrays have been used to investigate the effects of arcing within a wide range of neutral gas pressures, ion currents, and electron number densities. All data (except video) were obtained in digital form that allowed us to study the correlation between external parameters (plasma density, additional capacitance, bias voltage, etc) and arc characteristics (arc rate, arc current pulse width and amplitude, gas species partial pressures, intensities of spectral lines, and so on). Arc sites were determined by employing a video-camera, and it is shown that the most probable sites for arc inception are trip le-junctions, even though some arcs were initiated in gaps between cells. The effect of surface conditioning (decrease of arc rate due to outgassing) was clearly demonstrated. Moreover, a considerable increase in arc rate due to absorption of molecules from atmospheric air has been confirmed. The analysis of optical spectra (240-800 nm) reveals intense narrow atomic lines (Ag, H) and wide molecular bands (OH, CH, SiH, SiN) that confirm a complicated mechanism of arc plasma generation. The rate of plasma contamination due to arcing was measured by employing a mass-spectrometer. These measurements provided quite reliable data for the development of a theoretical model of plasma contamination, In conclusion, the arc threshold was increased to above 350 V (from 190 V) by keeping a sample in vacuum (20 micronTorr) for seven days. The results obtained are important for the understanding of the arc inception mechanism, which is absolutely essential for progress toward the design of high voltage solar arrays for space applications.

A systems thinking approach to analysis of the Patient Protection and Affordable Care Act.

PubMed

Williams, John C

2015-01-01

The public health community is challenged with understanding the many complexities presented by systems thinking and its applications in systems modeling. The model presented encompasses multiple variables needed (eg, model building) for the construction of a conceptual system model of the Patient Protection and Affordable Care Act (ACA). The model tracks the ACA from inception, through passage, March 2010, to its current state. Justification for the need to reform the current health care system rests, in part, on the heels of social justice. Proponents of the ACA have long argued that health reform was needed by the millions of uninsured person who suffered from health disparities, took little advantage of health prevention advice, and faced issues of access to providers as well as insurers. In addition the ACA seeks to address our uncontrollable spending on health care delivery. This article highlights the ACA from a systems perspective. The conceptual model presented encompasses both health reform variables (eg, health care provisions, key legislative components, system environment) and system variables (eg, inputs, outputs, feedback, and throughput) needed to understand current health care reform efforts from a systems perspective. The model presented shows how the interrelationships and interconnections of elements of a system come together to achieve its purpose or goal.

Why we do what we do: a theoretical evaluation of the integrated practice model for forensic nursing science.

PubMed

Valentine, Julie L

2014-01-01

An evaluation of the Integrated Practice Model for Forensic Nursing Science () is presented utilizing methods outlined by . A brief review of nursing theory basics and evaluation methods by Meleis is provided to enhance understanding of the ensuing theoretical evaluation and critique. The Integrated Practice Model for Forensic Nursing Science, created by forensic nursing pioneer Virginia Lynch, captures the theories, assumptions, concepts, and propositions inherent in forensic nursing practice and science. The historical background of the theory is explored as Lynch's model launched the role development of forensic nursing practice as both a nursing and forensic science specialty. It is derived from a combination of nursing, sociological, and philosophical theories to reflect the grounding of forensic nursing in the nursing, legal, psychological, and scientific communities. As Lynch's model is the first inception of forensic nursing theory, it is representative of a conceptual framework although the title implies a practice theory. The clarity and consistency displayed in the theory's structural components of assumptions, concepts, and propositions are analyzed. The model is described and evaluated. A summary of the strengths and limitations of the model is compiled followed by application to practice, education, and research with suggestions for ongoing theory development.

Managing the life cycle of electronic clinical documents.

PubMed

Payne, Thomas H; Graham, Gail

2006-01-01

To develop a model of the life cycle of clinical documents from inception to use in a person's medical record, including workflow requirements from clinical practice, local policy, and regulation. We propose a model for the life cycle of clinical documents as a framework for research on documentation within electronic medical record (EMR) systems. Our proposed model includes three axes: the stages of the document, the roles of those involved with the document, and the actions those involved may take on the document at each stage. The model includes the rules to describe who (in what role) can perform what actions on the document, and at what stages they can perform them. Rules are derived from needs of clinicians, and requirements of hospital bylaws and regulators. Our model encompasses current practices for paper medical records and workflow in some EMR systems. Commercial EMR systems include methods for implementing document workflow rules. Workflow rules that are part of this model mirror functionality in the Department of Veterans Affairs (VA) EMR system where the Authorization/ Subscription Utility permits document life cycle rules to be written in English-like fashion. Creating a model of the life cycle of clinical documents serves as a framework for discussion of document workflow, how rules governing workflow can be implemented in EMR systems, and future research of electronic documentation.

STRESSOR IDENTIFICATION: TECHNICAL GUIDANCE DOCUMENT

EPA Science Inventory

Since the inception of the Clean Water Act (CWA) in 1972, the rivers, lakes, estuaries, and wetlands of the United States have indeed become cleaner. The standard for meassuring these improvements are both chemical and biological. Yet, we know that many waterbodies still fail to ...

A next generation advanced traveler information precursor system (ATIS 2.0 precursor system) concept of operations.

DOT National Transportation Integrated Search

2016-10-27

Advanced Traveler Information Systems (ATIS) have experienced significant growth since its initial inception in the 1990s. Technologies have continued to evolve at a rapid pace, enabling the integration of advanced solutions for traveler information ...

MONITORING THE ACCOTINK CREEK STREAM RESTORATION

EPA Science Inventory

Since the inception of the Clean Water Act (CWA) in 1972, the United States has made great efforts in restoring and preserving the physical, chemical, and biological integrity of the Nation’s waters. However, nearly half of the nation’s assessed surface water resource...

A next generation advanced traveler information precursor system (ATIS 2.0 precursor system) system requirements.

DOT National Transportation Integrated Search

2016-12-01

Advanced Traveler Information Systems (ATIS) have experienced significant growth since their initial inception in the 1990s. Technologies have continued to evolve at a rapid pace, enabling the integration of advanced solutions for traveler informatio...

Fans, Football and Federal Elections: A Real-World Example of Statistics

ERIC Educational Resources Information Center

Cramer, Kenneth M.; Jackson, Dennis L.

2006-01-01

This article evaluates and explores the correlation (+0.892) between the United States federal election winner and the most recent Washington Redskin home-game winner, a relation perfectly linked for 17 of 18 elections since franchise inception in 1936.

45 CFR 148.316 - Grant application instructions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... application kit (see paragraph (b) of this section) along with the following information: (1) History and... that includes the following: (i) Brief history, including date of inception. (ii) Enrollment criteria... pool, including statutes, regulations and plan of operation. (2) Accounting of risk pool losses...

Environmental Toxicology and Chemistry at EPA's Western Ecology Division

EPA Science Inventory

The facility for the US Environmental Protection Agency’s Western Ecology Division (WED) has been involved in environmental toxicology and chemistry research since its inception in 1961 when it was the Pacific Northwest Water Laboratory. Currently, WED is one of four ecolog...

Alternative Retirement Plans.

ERIC Educational Resources Information Center

Hogan, John D.

1984-01-01

Alternative college retirement programs and features of a desirable retirement program are discussed. The historical, social, and economic forces that prompt institutions to consider alternative programs are identified. The present position of college faculty in terms of retirement options is also addressed. Since its inception, the Teachers…

The China Project.

ERIC Educational Resources Information Center

Gross, Steve; Juefei, Wang

1991-01-01

Nearly half of all Vermont school districts have participated in the China Project since its inception in 1986. During the program's first two years, participants examined Chinese history, politics, economy, geography, philosophy, arts, ancient inventions, foreign policy, social life, women's social status, the Chinese language, and the Beijing…

Interim report to the U.S. Congress on the Nonmotorized Transportation Pilot Program, SAFETEA-LU Section 1807

DOT National Transportation Integrated Search

2007-11-01

This interim report to Congress summarizes the progress and initial results of the Federal Highway Administrations (FHWA) and the four pilot communities participation in the Nonmotorized Transportation Pilot Program (NTPP) from its inception th...

A next generation advanced traveler information precursor system (ATIS 2.0 precursor system) use cases report.

DOT National Transportation Integrated Search

2017-05-01

Advanced Traveler Information Systems (ATIS) have experienced significant growth since their initial inception in the 1990s. Technologies have continued to evolve at a rapid pace, enabling the integration of advanced solutions for traveler informatio...

Inception point for embankment dam stepped spillways

USDA-ARS?s Scientific Manuscript database

Stepped spillways applied to embankment dams have become a common design practice with the rehabilitation of aging watershed dams, especially those experiencing a hazard classification change from low to high hazard. Previous research on stepped spillways focused on gravity dams where aerated flow ...

Neuropsychiatric SLE: from animal model to human.

PubMed

Pikman, R; Kivity, S; Levy, Y; Arango, M-T; Chapman, J; Yonath, H; Shoenfeld, Y; Gofrit, S G

2017-04-01

Animal models are a key element in disease research and treatment. In the field of neuropsychiatric lupus research, inbred, transgenic and disease-induced mice provide an opportunity to study the pathogenic routes of this multifactorial illness. In addition to achieving a better understanding of the immune mechanisms underlying the disease onset, supplementary metabolic and endocrine influences have been discovered and investigated. The ever-expanding knowledge about the pathologic events that occur at disease inception enables us to explore new drugs and therapeutic approaches further and to test them using the same animal models. Discovery of the molecular targets that constitute the pathogenic basis of the disease along with scientific advancements allow us to target these molecules with monoclonal antibodies and other specific approaches directly. This novel therapy, termed "targeted biological medication" is a promising endeavor towards producing drugs that are more effective and less toxic. Further work to discover additional molecular targets in lupus' pathogenic mechanism and to produce drugs that neutralize their activity is needed to provide patients with safe and efficient methods of controlling and treating the disease.

Supraglacial channel inception: Modeling and processes

NASA Astrophysics Data System (ADS)

Mantelli, E.; Camporeale, C.; Ridolfi, L.

2015-09-01

Supraglacial drainage systems play a key role in glacial hydrology. Nevertheless, physical processes leading to spatial organization in supraglacial networks are still an open issue. In the present work we thus address from a quantitative point of view the question of what is the physics leading to widely observed patterns made up of evenly spaced channels. To this aim, we set up a novel mathematical model describing a condition antecedent channel formation, i.e., the down-glacier flow of a distributed meltwater film. We then perform a linear stability analysis to assess whether the ice-water interface undergoes a morphological instability compatible with observed patterns. The instability is detected, its features depending on glacier surface slope, ice friction factor, and water as well as ice thermal conditions. By contrast, in our model channel spacing is solely hydrodynamically driven and relies on the interplay between pressure perturbations, flow depth response, and Reynolds stresses. Geometrical features of the predicted pattern are quantitatively consistent with available field data. The hydrodynamic origin of supraglacial channel morphogenesis suggests that alluvial patterns might share the same physical controls.

Establishing a general medical outpatient clinic for cancer survivors in a public city hospital setting.

PubMed

Goytia, Elliott J; Lounsbury, David W; McCabe, Mary S; Weiss, Elisa; Newcomer, Meghan; Nelson, Deena J; Brennessel, Debra; Rapkin, Bruce D; Kemeny, M Margaret

2009-11-01

Many cancer centers and community hospitals are developing novel models of survivorship care. However, few are specifically focused on services for socio-economically disadvantaged cancer survivors. To describe a new model of survivorship care serving culturally diverse, urban adult cancer patients and to present findings from a feasibility evaluation. Adult cancer patients treated at a public city hospital cancer center. The clinic provides comprehensive medical and psychosocial services for patients within a public hospital cancer center where they receive their oncology care. Longitudinal data collected over a 3-year period were used to describe patient demographics, patient needs, and services delivered. Since inception, 410 cancer patients have been served. Demand for services has grown steadily. Hypertension was the most frequent comorbid condition treated. Pain, depression, cardiovascular disease, hyperlipidemia, and bowel dysfunction were the most common post-treatment problems experienced by the patients. Financial counseling was an important patient resource. This new clinical service has been well-integrated into its public urban hospital setting and constitutes an innovative model of health-care delivery for socio-economically challenged, culturally diverse adult cancer survivors.

Stereoscopic display of 3D models for design visualization

NASA Astrophysics Data System (ADS)

Gilson, Kevin J.

2006-02-01

Advances in display technology and 3D design visualization applications have made real-time stereoscopic visualization of architectural and engineering projects a reality. Parsons Brinkerhoff (PB) is a transportation consulting firm that has used digital visualization tools from their inception and has helped pioneer the application of those tools to large scale infrastructure projects. PB is one of the first Architecture/Engineering/Construction (AEC) firms to implement a CAVE- an immersive presentation environment that includes stereoscopic rear-projection capability. The firm also employs a portable stereoscopic front-projection system, and shutter-glass systems for smaller groups. PB is using commercial real-time 3D applications in combination with traditional 3D modeling programs to visualize and present large AEC projects to planners, clients and decision makers in stereo. These presentations create more immersive and spatially realistic presentations of the proposed designs. This paper will present the basic display tools and applications, and the 3D modeling techniques PB is using to produce interactive stereoscopic content. The paper will discuss several architectural and engineering design visualizations we have produced.

System Engineering Strategy for Distributed Multi-Purpose Simulation Architectures

NASA Technical Reports Server (NTRS)

Bhula, Dlilpkumar; Kurt, Cindy Marie; Luty, Roger

2007-01-01

This paper describes the system engineering approach used to develop distributed multi-purpose simulations. The multi-purpose simulation architecture focuses on user needs, operations, flexibility, cost and maintenance. This approach was used to develop an International Space Station (ISS) simulator, which is called the International Space Station Integrated Simulation (ISIS)1. The ISIS runs unmodified ISS flight software, system models, and the astronaut command and control interface in an open system design that allows for rapid integration of multiple ISS models. The initial intent of ISIS was to provide a distributed system that allows access to ISS flight software and models for the creation, test, and validation of crew and ground controller procedures. This capability reduces the cost and scheduling issues associated with utilizing standalone simulators in fixed locations, and facilitates discovering unknowns and errors earlier in the development lifecycle. Since its inception, the flexible architecture of the ISIS has allowed its purpose to evolve to include ground operator system and display training, flight software modification testing, and as a realistic test bed for Exploration automation technology research and development.

Evolution of Monitoring and Evaluation of AIDS Response in Ukraine: Laying the Groundwork for Evidence-Based Health Care.

PubMed

Dumchev, Kostyantyn; Varetska, Olga; Kuzin, Ihor

2017-07-01

Once facing the most severe HIV epidemic in Eastern Europe, Ukraine has built an elaborate Monitoring and Evaluation (M&E) system to track the response to AIDS. This system was developed using recommendations and input from multiple international expert organizations and donors and, at the current stage, serves as a best practice model in many areas. The present paper aims to provide a comprehensive overview of the evolution of the M&E system in Ukraine since its inception. Notable achievements and challenges are described and illustrated by epidemiological data and the recommendations for future development are discussed. Unique experiences and advances in M&E in Ukraine may be useful to other countries facing similar epidemiological, structural or methodological issues.

Development of an Online Smartphone-Based eLearning Nutrition Education Program for Low-Income Individuals.

PubMed

Stotz, Sarah; Lee, Jung Sun

2018-01-01

The objective of this report was to describe the development process of an innovative smartphone-based electronic learning (eLearning) nutrition education program targeted to Supplemental Nutrition Assistance Program-Education-eligible individuals, entitled Food eTalk. Lessons learned from the Food eTalk development process suggest that it is critical to include all key team members from the program's inception using effective inter-team communication systems, understand the unique resources needed, budget ample time for development, and employ an iterative development and evaluation model. These lessons have implications for researchers and funding agencies in developing an innovative evidence-based eLearning nutrition education program to an increasingly technology-savvy, low-income audience. Copyright © 2016 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

Cavitation-induced fragmentation of an acoustically-levitated droplet

NASA Astrophysics Data System (ADS)

Gonzalez Avila, Silvestre Roberto; Ohl, Claus-Dieter

2015-12-01

In this paper we investigate the initial sequence of events that lead to the fragmentation of a millimetre sized water droplets when interacting with a focused ns-laser pulse. The experimental results show complex processes that result from the reflection of an initial shock wave from plasma generation with the soft boundary of the levitating droplet; furthermore, when the reflected waves from the walls of the droplet refocus they leave behind a trail of microbubbles that later act as cavitation inception regions. Numerical simulations of a shock wave impacting and reflecting from a soft boundary are also reported; the simulated results show that the lowest pressure inside the droplet occurs at the equatorial plane. The results of the numerical model display good agreement with the experimental results both in time and in space.

Perceived patient control over personal health information in the presence of context-specific concerns

NASA Astrophysics Data System (ADS)

Nanayakkara, Prabhashi A.

Information privacy issues have plagued the world of electronic media since its inception. This research focused mainly on factors that increase or decrease perceived patient control over personal health information (CTL) in the presence of context-specific concerns. Control agency theory was used for the paper's theoretical contributions. Personal and proxy control agencies acted as the independent variables, and context-specific concerns for information privacy (CFIP) were used as the moderator between proxy control agency, healthcare provider, and CTL. Demographic data and three control variables-- the desire for information control, privacy experience, and trust propensity--were also included in the model to gauge the contribution to CTL from external factors. Only personal control agency and desire for information control were found to impact CTL.

A crystallographic perspective on sharing data and knowledge

NASA Astrophysics Data System (ADS)

Bruno, Ian J.; Groom, Colin R.

2014-10-01

The crystallographic community is in many ways an exemplar of the benefits and practices of sharing data. Since the inception of the technique, virtually every published crystal structure has been made available to others. This has been achieved through the establishment of several specialist data centres, including the Cambridge Crystallographic Data Centre, which produces the Cambridge Structural Database. Containing curated structures of small organic molecules, some containing a metal, the database has been produced for almost 50 years. This has required the development of complex informatics tools and an environment allowing expert human curation. As importantly, a financial model has evolved which has, to date, ensured the sustainability of the resource. However, the opportunities afforded by technological changes and changing attitudes to sharing data make it an opportune moment to review current practices.

The role of upper-regime flow bedforms in the morphodynamics of submarine channels

NASA Astrophysics Data System (ADS)

Covault, Jacob A.; Kostic, Svetlana; Fildani, Andrea

2014-05-01

Advances in acoustic imaging of submarine canyons and channels have provided accurate renderings of seafloor geomorphology. Still, a fundamental understanding of channel inception, evolution, sediment transport, and the nature of the currents traversing these channels remains elusive. Here, we review a mosaic of geomorphology, shallow stratigraphy, and morphodynamics of channelized deep-water depositional systems of tectonically active slopes offshore of California, USA. These systems are imaged in high-resolution multi-beam sonar bathymetry (dominant frequency ~200 kHz) and seismic-reflection (2-16 kHz) data. From north to south, the Monterey East, Lucia Chica, and San Mateo channelized deep-water depositional systems show a breadth of geomorphology and stratigraphic architecture, including channel reaches of varying sinuosity, levees, terraces within channels, and crescent-shaped bedforms, especially in the thalwegs of incipient channel elements. Morphodynamic numerical modeling is combined with interpretations of seafloor and shallow subsurface stratigraphic imagery to demonstrate that the crescent-shaped bedforms common to channel thalwegs are likely to be cyclic steps. We propose that net-erosional and net-depositional cyclic steps play a fundamental role in the formation, filling, and maintenance phases of submarine channels in continental margins with high gradient, locally rugose bathymetry. These margins include passive-margin slopes subjected to gravity-driven tectonic deformation. In such settings, high gradients support the development of densimetric Froude-supercritical turbidity currents, and abrupt slope breaks can promote hydraulic jumps and the spontaneous evolution of an erodible seabed into cyclic steps. This morphodynamic investigation of turbidity currents and the seafloor has the potential to enhance prediction of the locations, stratigraphic evolution, and architecture of submarine canyon-channel systems.

Extraction of Built-Up Areas Using Convolutional Neural Networks and Transfer Learning from SENTINEL-2 Satellite Images

NASA Astrophysics Data System (ADS)

Bramhe, V. S.; Ghosh, S. K.; Garg, P. K.

2018-04-01

With rapid globalization, the extent of built-up areas is continuously increasing. Extraction of features for classifying built-up areas that are more robust and abstract is a leading research topic from past many years. Although, various studies have been carried out where spatial information along with spectral features has been utilized to enhance the accuracy of classification. Still, these feature extraction techniques require a large number of user-specific parameters and generally application specific. On the other hand, recently introduced Deep Learning (DL) techniques requires less number of parameters to represent more abstract aspects of the data without any manual effort. Since, it is difficult to acquire high-resolution datasets for applications that require large scale monitoring of areas. Therefore, in this study Sentinel-2 image has been used for built-up areas extraction. In this work, pre-trained Convolutional Neural Networks (ConvNets) i.e. Inception v3 and VGGNet are employed for transfer learning. Since these networks are trained on generic images of ImageNet dataset which are having very different characteristics from satellite images. Therefore, weights of networks are fine-tuned using data derived from Sentinel-2 images. To compare the accuracies with existing shallow networks, two state of art classifiers i.e. Gaussian Support Vector Machine (SVM) and Back-Propagation Neural Network (BP-NN) are also implemented. Both SVM and BP-NN gives 84.31 % and 82.86 % overall accuracies respectively. Inception-v3 and VGGNet gives 89.43 % of overall accuracy using fine-tuned VGGNet and 92.10 % when using Inception-v3. The results indicate high accuracy of proposed fine-tuned ConvNets on a 4-channel Sentinel-2 dataset for built-up area extraction.

Promoting a smokers' quitline in Ontario, Canada: an evaluation of an academic detailing approach.

PubMed

Kirst, Maritt; Schwartz, Robert

2015-06-01

This study assesses the impact of an academic detailing quitline promotional outreach program on integration of patient referrals to the quitline by fax in healthcare settings and quitline utilization in Ontario, Canada. The study employed a mixed methods approach for evaluation, with trend analysis of quitline administrative data from the year before program inception (2005) to 2011 and qualitative interviews with quitline stakeholders. Participants in the qualitative interviews included academic detailing program staff, regional tobacco control stakeholders and quitline promotion experts. Quantitative outcomes included the number of fax referral partners and fax referrals received, and quitline reach. Trends in proximal and distal outreach program outcomes were assessed. The qualitative data were analysed through a process of data coding involving the constant comparative technique derived from grounded theory methods. The study identified that the outreach program has had some success in integrating the fax referral program in healthcare settings through evidence of increased fax referrals since program inception. However, organizational barriers to program partner engagement have been encountered. While referral from health professionals through the fax referral programs has increased since the inception of the outreach program, the overall reach of the quitline has not increased. The study findings highlight that an academic detailing approach to quitline promotion can have some success in achieving increased fax referral program integration in healthcare settings. However, findings suggest that investment in a comprehensive promotional strategy, incorporating academic detailing, media and the provision of free cessation medications may be a more effective approach to quitline promotion. © The Author (2013). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

NYPA/TH!NK Clean Commute Program Report – Inception through February 2003

DOE Office of Scientific and Technical Information (OSTI.GOV)

Don Karner; James Francfort

The Clean Commute Program uses TH!NK city electric vehicles from Ford Motor Company’s electric vehicle group, TH!NK Mobility, to demonstrate the feasibility of using electric transportation in urban applications. The primary Program partners are the New York Power Authority (NYPA) and Ford. The other Program partners providing funding and other support include the Metropolitan Transportation Authority, Metro North Railroad, Long Island Railroad, New York State Energy Research and Development Authority, Long Island Power Authority, New York State Department of Transportation, New York City Department of Transportation, and the U.S. Department of Energy’s Advanced Vehicle Testing Activity (AVTA). The data inmore » this report is being collected via an internet-based questionnaire system by the AVTA through its subcontractor Electric Transportation Applications. Suburban New York City railroad commuters use the TH!NK city vehicles to commute from their private residences to railroad stations where they catch commuter trains into New York City. Electric vehicle charging infrastructure for the TH!NK cities is located at the commuters’ private residences as well as seven train stations. Eighty-seven commuters are using the TH!NK city vehicles, with 80% actively providing data to the AVTA. The participants have driven the vehicles nearly 150,000 miles since Program inception, avoiding the use of almost 7,000 gallons of gasoline. The TH!NK city vehicles are driven an average of between 180 and 230 miles per month, and over 95% of all trips taken with the TH!NK city vehicles replace trips previously taken in gasoline vehicles. This report covers the period from Program inception through February 2003.« less

Psychiatric inpatient care at a county hospital before and after the inception of a university-affiliated psychiatry residency program.

PubMed

Woo, Benjamin K P; Ma, Albert Y

2007-09-01

The University of California, Los Angeles (UCLA), along with Kern Medical Center (KMC) and Kern County Mental Health (KCMH), established a new psychiatry residency program in 2004. In this study, we compared psychiatric care at a county psychiatric facility serving a population of 760,000 inhabitants before and after the initiation of this psychiatry residency program. Medical charts for all patients admitted to the psychiatric inpatient service during the year before the inception of the psychiatry residency program (2003-2004) and during the first year in which there was full implementation of residents after inception of the psychiatry residency program (2005-2006) were reviewed. Baseline characteristics, demographics, and various outcomes of the two groups were compared. After the residency program was established, the mean length of stay increased from 8.8 to 9.8 days (p < 0.05), the 30-day readmission rate increased from 3.5% (32/915) to 5.6% (48/853) (p < 0.05), more intramuscular emergency medications were given (p < 0.01), and more radiological assessments were obtained (p < 0.01). However, there was less delay in discharge (p < 0.01) and fewer days without medical necessity (p < 0.01). The patient satisfaction rate dropped from 77% (547/711) to 70% (476/680) (p < 0.01) after initiation of the residency program. The results of this study suggest a statistically significant difference in multiple characteristics of treatment after initiation of a psychiatry residency program in the psychiatric inpatient setting. More research is needed to identify strategies, such as guidelines to eliminate over-utilization of resources and methods to improve residents' competency, that may successfully enhance the quality of care provided by residents to psychiatric inpatients.

Improving patient survival with the colorectal cancer multi-disciplinary team.

PubMed

MacDermid, E; Hooton, G; MacDonald, M; McKay, G; Grose, D; Mohammed, N; Porteous, C

2009-03-01

There is little information on the impact of the colorectal multi-disciplinary team (MDT) in the United Kingdom. Our single operator presented his patients before and after the inception of an MDT meeting in June 2002. The aim of this study was to assess the effect of this on his patients' survival, and trends in the use of adjuvant chemotherapy. Data were collected on all patients (n = 310) undergoing colectomy for colorectal cancer by one surgeon. Excluding patients with Dukes A stage, the pre-MDT cohort from January 1997 to May 2002 was 176 and the post-MDT cohort from June 2002 to December 2005 was 134. Three-year survival rates were calculated using Kaplan-Meier life table analysis. Prognostic factors were analysed using Cox-proportional hazard regression, and chemotherapy data analysed using the chi-squared test. Independent prognostic indicators of chemotherapy prescription were examined using binary logistic testing. MDT status was shown to be an independent predictor of survival on hazard regression analysis (P = 0.044). A significantly greater number of patients were prescribed adjuvant chemotherapy in the post-MDT cohort (P = 0.0002). MDT status was shown to be a significant prognostic indicator of chemotherapy prescription (P < 0.0001). Three-year survival for Dukes C patients was 58% in the pre-MDT group, and 66% in the post-MDT group (P = 0.023). There was a significant increase in patients undergoing adjuvant postoperative chemotherapy after the inception of the MDT. This was associated with a significant survival benefit in patients with Dukes C disease. The data suggest that the MDT process has resulted in an increase in the prescription of adjuvant chemotherapy, with 3-year survival being greater after its inception.

Study of the Unsteady Flow Features on a Stalled Wing

NASA Technical Reports Server (NTRS)

Yon, Steven A.; Katz, Joseph

1997-01-01

The occurrence of large scale structures in the post stall flow over a rectangular wing at high angles of attack was investigated in a small-scale subsonic wind tunnel. Mean and time dependent measurements within the separated flow field suggest the existence of two distinct angle of attack regimes beyond wing stall. The shallow stall regime occurs over a narrow range of incidence angles (2-3 deg.) immediately following the inception of leading edge separation. In this regime, the principal mean flow structures, termed stall cells, are manifested as a distinct spanwise periodicity in the chordwise extent of the separated region on the model surface with possible lateral mobility not previously reported. Within the stall cells and on the wing surface, large amplitude pressure fluctuations occur with a frequency much lower than anticipated for bluff body shedding, and with minimum effect in the far wake. In the deep stall regime, stall cells are not observed and the separated region near the model is relatively free of large amplitude pressure disturbances.

Stereoscopic applications for design visualization

NASA Astrophysics Data System (ADS)

Gilson, Kevin J.

2007-02-01

Advances in display technology and 3D design visualization applications have made real-time stereoscopic visualization of architectural and engineering projects a reality. Parsons Brinkerhoff (PB) is a transportation consulting firm that has used digital visualization tools from their inception and has helped pioneer the application of those tools to large scale infrastructure projects. PB is one of the first Architecture/Engineering/Construction (AEC) firms to implement a CAVE- an immersive presentation environment that includes stereoscopic rear-projection capability. The firm also employs a portable stereoscopic front-projection system, and shutter-glass systems for smaller groups. PB is using commercial real-time 3D applications in combination with traditional 3D modeling programs to visualize and present large AEC projects to planners, clients and decision makers in stereo. These presentations create more immersive and spatially realistic presentations of the proposed designs. This paper will present the basic display tools and applications, and the 3D modeling techniques PB is using to produce interactive stereoscopic content. The paper will discuss several architectural and engineering design visualizations we have produced.

The Mid America Heart Institute: part II.

PubMed

McCallister, Ben D; Steinhaus, David M

2003-01-01

The Mid America Heart Institute (MAHI) is one of the first and largest hospitals developed and designed specifically for cardiovascular care. The MAHI hybrid model, which is a partnership between the not-for-profit Saint Luke's Health System, an independent academic medical center, and a private practice physician group, has been extremely successful in providing high-quality patient care as well as developing strong educational and research programs. The Heart Institute has been the leader in providing cardiovascular care in the Kansas City region since its inception in 1975. Although challenges in the future are substantial, it is felt that the MAHI is in an excellent position to deal with the serious issues in health care because of the Heart Institute, its facility, organization, administration, dedicated medical and support staff, and its unique business model of physician management. In part I, the authors described the background and infrastructure of the Heart Institute. In part II, cardiovascular research and benefits of physician management are addressed.

The Mid America Heart Institute: part 1.

PubMed

McCallister, Ben D; Steinhaus, David M

2003-01-01

The Mid America Heart Institute (MAHI) is one of the first and largest hospitals developed and designed specifically for cardiovascular care. The MAHI hybrid model, which is a partnership between the not-for-profit Saint Luke's Health System, an independent academic medical center, and a private practice physician group, has been extremely successful in providing high-quality patient care as well as developing strong educational and research programs. The Heart Institute has been the leader in providing cardiovascular care in the Kansas City region since its inception in 1975. Although challenges in the future are substantial, it is felt that the MAHI is in an excellent position to deal with the serious issues in health care because of the Heart Institute, its facility, organization, administration, dedicated medical and support staff, and its unique business model of physician management. In part I, the authors describe the background and infrastructure of the Heart Institute. In part II, cardiovascular research and benefits of physician management will be addressed.

Predictors of remission in DSM hypochondriasis.

PubMed

Barsky, A J; Bailey, E D; Fama, J M; Ahern, D K

2000-01-01

Although hypochondriasis is generally believed to be a chronic and refractory disorder, relatively little is known about its natural history and course. Based on a cognitive/perceptual model of hypochondriasis, we hypothesized that the disorder would be more chronic in patients who both amplify benign bodily symptoms and tend to attribute them to disease. Thirty-eight patients with DSM hypochondriasis were assessed with a structured, diagnostic interview and self-report questionnaire. A logistic regression model containing sociodemographic characteristics and a 3-way interaction term composed of the tendency to amplify bodily sensations, the tendency to attribute common symptoms to disease, and somatization (all measured at inception) correctly classified the remission status of 81.6% of the patients at follow-up 4 years later. These results suggest that patients who somatize, who are amplifiers of bodily sensation, and those who tend to attribute ambiguous symptoms to disease have more chronic and more refractory hypochondriasis. It is the co-occurrence of these cognitive and perceptual characteristics, rather than their occurrence individually, which predicts the persistence of this disorder.

Towards a Three-Component Model of Fan Loyalty: A Case Study of Chinese Youth

PubMed Central

Zhang, Xiao-xiao; Liu, Li; Zhao, Xian; Zheng, Jian; Yang, Meng; Zhang, Ji-qi

2015-01-01

The term “fan loyalty” refers to the loyalty felt and expressed by a fan towards the object of his/her fanaticism in both everyday and academic discourses. However, much of the literature on fan loyalty has paid little attention to the topic from the perspective of youth pop culture. The present study explored the meaning of fan loyalty in the context of China. Data were collected by the method of in-depth interviews with 16 young Chinese people aged between 19 and 25 years who currently or once were pop fans. The results indicated that fan loyalty entails three components: involvement, satisfaction, and affiliation. These three components regulate the process of fan loyalty development, which can be divided into four stages: inception, upgrade, zenith, and decline. This model provides a conceptual explanation of why and how young Chinese fans are loyal to their favorite stars. The implications of the findings are discussed. PMID:25886557

A 17-Month Review of the Care Model, Service Structure, and Design of THRIVE, a Community Mental Health Initiative in Northern Singapore.

PubMed

Cheang, K M; Cheok, C C S

2015-12-01

Effective delivery of psychiatric care requires the development of a range of services. The existing Singapore health care system provides a comprehensive range of psychiatric services based in restructured hospitals. The Ministry of Health Community Mental Health Masterplan (2012-2017) aims to build novel services for the community. This Masterplan envisions the development of ASCATs (Assessment Shared Care Teams) and COMITs (Community Intervention Teams) to build the capacity and capability for psychiatric care to be delivered outside the hospital in the community. A community mental health plan comprising a fast access clinic, internet-delivered self-help and building a community network of providers was devised for the North of Singapore through the THRIVE (Total Health Rich In Vitality and Energy) programme. This article provides an introduction to the care model, service structure and design of the THRIVE, and reviews its milestones and achievements from its inception in August 2012 until December 2013.

The influence of a Vascular Surgery Hospitalist program on physician and patient satisfaction, resident education, and resource utilization.

PubMed

Cull, David L; Langan, Eugene M; Taylor, Spence M; Carsten, Christopher G; Tong, Angie; Johnson, Brent

2013-10-01

A number of surgery practice models have been developed to address general and trauma surgeon workforce shortages and on-call issues and to improve surgeon satisfaction. These include the creation of acute or urgent care surgery services and "surgical hospitalist" programs. To date, no practice models corresponding to those developed for general and trauma surgeons have been proposed to address these same issues among vascular surgeons or other surgical subspecialists. In 2003, our practice established a Vascular Surgery Hospitalist program. Since its inception nearly a decade ago, it has undergone several modifications. We reviewed hospital administrative databases and surveys of faculty, residents, and patients to evaluate the program's impact. Benefits of the Vascular Surgery Hospitalist program include improved surgeon satisfaction, resource utilization, timeliness of patient care, communication among referring physicians and ancillary staff, and resident teaching/supervision. Elements of this program may be applicable to a variety of surgical subspecialty settings. Copyright © 2013 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.

Spinal Cord Injury Model Systems: Review of Program and National Database From 1970 to 2015.

PubMed

Chen, Yuying; DeVivo, Michael J; Richards, J Scott; SanAgustin, Theresa B

2016-10-01

The Spinal Cord Injury Model Systems (SCIMS) centers have provided continuous, comprehensive multidisciplinary care for persons with spinal cord injury (SCI) in the United States since their inception in 1970. In addition, the research conducted and the analysis of data collected at these centers facilitate advances in the care and the overall quality of life for people with SCI. Over the past 45 years, the SCIMS program and National Spinal Cord Injury Database (NSCID) have undergone major revisions, which must be recognized in the planning, conduct, and interpretation of SCIMS research to prevent misinterpretation of findings. Therefore, we provide herein a brief review of the SCIMS program and the associated NSCID throughout its history, emphasizing changes and accomplishments within the past 15 years, to facilitate a better understanding and interpretation of the data presented in SCIMS research publications, including the articles published in this special issue of the Archives. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

ORDEM2010 and MASTER-2009 Modeled Small Debris Population Comparison

NASA Technical Reports Server (NTRS)

Krisko, Paula H.; Flegel, S.

2010-01-01

The latest versions of the two premier orbital debris engineering models, NASA s ORDEM2010 and ESA s MASTER-2009, have been publicly released. Both models have gone through significant advancements since inception, and now represent the state-of-the-art in orbital debris knowledge of their respective agencies. The purpose of these models is to provide satellite designers/operators and debris researchers with reliable estimates of the artificial debris environment in near-Earth orbit. The small debris environment within the size range of 1 mm to 1 cm is of particular interest to both human and robotic spacecraft programs. These objects are much more numerous than larger trackable debris but are still large enough to cause significant, if not catastrophic, damage to spacecraft upon impact. They are also small enough to elude routine detection by existing observation systems (radar and telescope). Without reliable detection the modeling of these populations has always coupled theoretical origins with supporting observational data in different degrees. This paper details the 1 mm to 1 cm orbital debris populations of both ORDEM2010 and MASTER-2009; their sources (both known and presumed), current supporting data and theory, and methods of population analysis. Fluxes on spacecraft for chosen orbits are also presented and discussed within the context of each model.

New Departure from Nucleate Boiling model relying on first principle energy balance at the boiling surface

NASA Astrophysics Data System (ADS)

Demarly, Etienne; Baglietto, Emilio

2017-11-01

Predictions of Departure from Nucleate Boiling have been a longstanding challenge when designing heat exchangers such as boilers or nuclear reactors. Many mechanistic models have been postulated over more than 50 years in order to explain this phenomenon but none is able to predict accurately the conditions which trigger the sudden change of heat transfer mode. This work aims at demonstrating the pertinence of a new approach for detecting DNB by leveraging recent experimental insights. The new model proposed departs from all the previous models by making the DNB inception come from an energy balance instability at the heating surface rather than a hydrodynamic instability of the bubbly layer above the surface (Zuber, 1959). The main idea is to modulate the amount of heat flux being exchanged via the nucleate boiling mechanism by the wetted area fraction on the surface, thus allowing a completely automatic trigger of DNB that doesn't require any parameter prescription. This approach is implemented as a surrogate model in MATLAB in order to validate the principles of the model in a simple and controlled geometry. Good agreement is found with the experimental data leveraged from the MIT Flow Boiling at various flow regimes. Consortium for Advanced Simulation of Light Water Reactors (CASL).

Nurse-Managed Clinics: A Blueprint for Success Using the Covey Framework.

ERIC Educational Resources Information Center

Starck, Patricia L.; And Others

1995-01-01

Describes the process from inception to successful operation of a university-based, nurse-managed clinic, based on Covey's seven habits of highly effective people. Includes information on the planning process, financing, political strategies for gaining approval, and ongoing development of services. (JOW)

Looking to the Future of the Air Force Nuclear Enterprise

DTIC Science & Technology

2016-09-01

DISTRIBUTION UNLIMITED. The views expressed in this thesis are those of the author and do not reflect the...take to move to the future. This thesis seeks to answer the following question: Examining the Air Force Nuclear Enterprise from its inception in

Mobile-Assisted Second Language Learning: Developing a Learner-Centered Framework

ERIC Educational Resources Information Center

Leow, Choy Khim; Yahaya, Wan Ahmad Jaafar Wan; Samsudin, Zarina

2014-01-01

The Mobile Assisted Language Learning concept has offered infinite language learning opportunities since its inception 20 years ago. Second Language Acquisition however embraces a considerably different body of knowledge from first language learning. While technological advances have optimized the psycholinguistic environment for language…

Disability Studies and Art Education

ERIC Educational Resources Information Center

Derby, John

2011-01-01

This article promotes the field of disability studies as a valuable resource for expanding art education's concept of disability and as a promising venue for interdisciplinary dialogue. While art education has persistently supported special education since its inception, disability advocacy has advanced in the past two decades toward…

The Invention Notebook Challenge

ERIC Educational Resources Information Center

Roman, Harry T.

2018-01-01

Like scientists who keep lab notebooks detailing their experiments, inventors keep invention notebooks that chronologically detail the inception, development, and refinement of their inventions. These notebooks are legal documents that can help prove one inventor's precedent over another. Scenarios like these are very real, as the author has had…

A Redesigned DFA Moisture Meter

USDA-ARS?s Scientific Manuscript database

The DFA moisture meter has been internationally recognized as the standard for determining moisture content of dried fruit in general and is AOAC Official Method 972.2 for measuring moisture in prunes and raisins since 1972. The device has remained virtually unchanged since its inception, with its o...

Congestion relief by travel time minimization in near real time : Detroit area I-75 corridor study.

DOT National Transportation Integrated Search

2008-12-01

"This document summarizes the activities concerning the project: Congestion Relief by : Travel Time Minimization in Near Real Time -- Detroit Area I-75 Corridor Study since : the inception of the project (Nov. 22, 2006 through September 30, 2008). : ...

Industrial Restructuring Training Programme. Evaluation Report.

ERIC Educational Resources Information Center

European Social Fund, Dublin (Ireland).

Ireland's Industrial Restructuring Training Programme (IRTP) was evaluated to determine its effectiveness as a vehicle for improving the managerial and supervisory skill levels of employees in existing enterprises. Data were collected from the following sources: review of all program-monitoring documents submitted since the IRTP's inception;…

The history and future of dietary guidance in America

USDA-ARS?s Scientific Manuscript database

Evidence-based dietary guidance in the US has progressed substantially since its inception over 100 years ago. This review describes the historical development and significance of dietary guidance in the US, including the Dietary Guidelines for Americans, and emphasizes the foundations upon which th...

Observations on dam cvertopping protection: RCC stepped spillway research

USDA-ARS?s Scientific Manuscript database

Research conducted over the last decade has led to improved understanding on the design and hydraulic performance of stepped spillways applied to embankment dams for overtopping protection. This research has demonstrated that the free-surface air entrainment inception point (Li), step height to cri...

Practice and Progression in Second Language Research Methods

ERIC Educational Resources Information Center

Mackey, Alison

2014-01-01

Since its inception, the field of second language research has utilized methods from a number of areas, including general linguistics, psychology, education, sociology, anthropology and, recently, neuroscience and corpus linguistics. As the questions and objectives expand, researchers are increasingly pushing methodological boundaries to gain a…

Affirmative Action: History and Analysis

ERIC Educational Resources Information Center

Garrison-Wade, Dorothy F.; Lewis, Chance W.

2004-01-01

From its inception, affirmative action policies were created to improve the employment and/or educational opportunities for members of minority groups and women. Even today, however, the debate continues over the future of affirmative action. Proponents offer empirical evidence illustrating that affirmative action has been favorable in aiding…

The Family-Environment Connection: Filling a Nationwide Program Gap

ERIC Educational Resources Information Center

Santiago, Anthony; Franz, Nancy; Christoffel, Rebecca; Cooper, Kristi; Schmitt, Brenda

2013-01-01

Since its inception, Extension has focused on helping individuals, families, and communities change economic, environmental, and social conditions. Over the organization's history, environmental condition change programming has been mostly the purview of natural resource educators and less often conducted by family and consumer science…

Development of an online journal.

PubMed

Doheny, M; Thede, L

2000-01-01

This article describes the historical development of an electronic nursing journal, (OJIN), from inception to reality. Planning focused on a needs analysis for an electronic journal, audience and marketing concerns, editorial board membership, and financing of the journal. Included are recommendations for those considering starting an online journal.

Ecosystem services

Treesearch

Trista Patterson

2014-01-01

Since its inception, the ecosystem service approach has stimulated interest from numerous planning, management, and partnership perspectives. To date, however, research that quantifies ecosystem services in the study area (in the form of explicit ecosystem service studies) has been limited. This chapter reviews and synthesizes the concept of ecosystem services,...

Time, Weather and Empires: The Campos Rodrigues Observatory in Lourenço Marques, Mozambique (1905-1930).

PubMed

Raposo, Pedro M P

2015-07-01

In 1905 the Campos Rodrigues Observatory (CRO) was founded in Lourenço Marques (nowadays Maputo), the capital of Mozambique, by then part of the Portuguese overseas empire. In this paper the inception and early history of the CRO are analysed in the broader context of the interwoven history of the Portuguese and British empires in Africa, and specifically with respect to the scientific relations between Mozambique and South Africa. The equipment, personnel, practices and networks involved in the inception and early development of the CRO are brought into focus in order to illustrate the problems and strategies that shaped the establishment and functioning of this observatory, which was conceived essentially as a symbol of imperial stamina and colonial prowess. It is suggested that by providing a focal point for the development of scientific relations between Mozambique and South Africa, the CRO served both Portuguese ambitions for recognition as an imperial power and the emergence of South African nationalism.

Experimental breakdown of selected anodized aluminum samples in dilute plasmas

NASA Technical Reports Server (NTRS)

Grier, Norman T.; Domitz, Stanley

1992-01-01

Anodized aluminum samples representative of Space Station Freedom structural material were tested for electrical breakdown under space plasma conditions. In space, this potential arises across the insulating anodized coating when the spacecraft structure is driven to a negative bias relative to the external plasma potential due to plasma-surface interaction phenomena. For anodized materials used in the tests, it was found that breakdown voltage varied from 100 to 2000 volts depending on the sample. The current in the arcs depended on the sample, the capacitor, and the voltage. The level of the arc currents varied from 60 to 1000 amperes. The plasma number density varied from 3 x 10 exp 6 to 10 exp 3 ions per cc. The time between arcs increased as the number density was lowered. Corona testing of anodized samples revealed that samples with higher corona inception voltage had higher arcing inception voltages. From this it is concluded that corona testing may provide a method of screening the samples.

Canada on the Move: an intensive media analysis from inception to reception.

PubMed

Faulkner, Guy; Finlay, Sara-Jane

2006-01-01

Research evaluating mediated physical activity campaigns uses an unsophisticated conceptualization of the media and would benefit from the application of a media studies approach. The purpose of this article is to report on the application of this type of analysis to the Canada on the Move media campaign. Through interviews and document analysis, the press release surrounding Canada on the Move was examined at four levels: inception, production, transmission and reception. Analytic strategies of thematic and textual analysis were conducted. The press release was well received by journalists and editors and was successfully transmitted as inferred from national and local television coverage, although there was no national print pickup. Canada on the Move was perceived by sampled audience members as a useful and interesting strategy to encourage walking. A holistic approach to media analysis reveals the complex and frequently messy process of this mediated communication process. Implications for future media disseminations of Canada on the Move are discussed.

U.S. Spacesuit Knowledge Capture Status and Initiatives in Fiscal Year 2014

NASA Technical Reports Server (NTRS)

Chullen, Cinda; Oliva, Vladenka R.

2015-01-01

Since its 2008 inception, the NASA U.S. Spacesuit Knowledge Capture (KC) program has shared historical spacesuit information with engineers and other technical team members to expand their understanding of the spacesuit's evolution, known capability and limitations, and future desires and needs for its use. As part of the U.S. Spacesuit KC program, subject-matter experts have delivered presentations, held workshops, and participated in interviews to share valuable spacesuit lessons learned to ensure this vital information will survive for existing and future generations to use. These events have included spacesuit knowledge from the inception of NASA's first spacesuit to current spacesuit design. To ensure that this information is shared with the entire NASA community and other interested or invested entities, these KC events were digitally recorded and transcribed to be uploaded onto several applicable NASA Web sites. This paper discusses the various Web sites that the KC events are uploaded to and possible future sites that will channel this information.

U.S. Spacesuit Knowledge Capture Accomplishments in Fiscal Year 2014

NASA Technical Reports Server (NTRS)

Chullen, Cinda; Oliva, Vladenka R.

2015-01-01

Since its 2008 inception, the NASA U.S. Spacesuit Knowledge Capture (KC) program has shared historical spacesuit information with engineers and other technical team members to expand their understanding of the spacesuit's evolution, known capability and limitations, and future desires and needs for its use. As part of the U.S. Spacesuit KC program, subject-matter experts have delivered presentations, held workshops, and participated in interviews to share valuable spacesuit lessons learned to ensure this vital information will survive for existing and future generations to use. These events have included spacesuit knowledge from the inception of NASA's first spacesuit to current spacesuit design. To ensure that this information is shared with the entire NASA community and other interested or invested entities, these KC events were digitally recorded and transcribed to be uploaded onto several applicable NASA Web sites. This paper discusses the various Web sites that the KC events are uploaded to and possible future sites that will channel this information.

Characteristics of Partial Discharge and Ozone Generation for Twisted-pair of Enameled Wires under High-repetitive Impulse Voltage Application

NASA Astrophysics Data System (ADS)

Kanazawa, Seiji; Enokizono, Masato; Shibakita, Toshihide; Umehara, Eiji; Toshimitsu, Jun; Ninomiya, Shinji; Taniguchi, Hideki; Abe, Yukari

In recent years, inverter drive machines such as a hybrid vehicle and an electric vehicle are operated under high voltage pulse with high repetition rate. In this case, inverter surge is generated and affected the machine operation. Especially, the enameled wire of a motor is deteriorated due to the partial discharge (PD) and finally breakdown of the wire will occur. In order to investigate a PD on a resistant enameled wire, characteristics of PD in the twisted pair sample under bipolar repetitive impulse voltages are investigated experimentally. The relationship between the applied voltage and discharge current was measured at PD inception and extinction, and we estimated the repetitive PD inception and extinction voltages experimentally. The corresponding optical emission of the discharge was also observed by using an ICCD camera. Furthermore, ozone concentration due to the discharge was measured during the life-time test of the resistant enameled wires from a working environmental point of view.

Large deviations of a long-time average in the Ehrenfest urn model

NASA Astrophysics Data System (ADS)

Meerson, Baruch; Zilber, Pini

2018-05-01

Since its inception in 1907, the Ehrenfest urn model (EUM) has served as a test bed of key concepts of statistical mechanics. Here we employ this model to study large deviations of a time-additive quantity. We consider two continuous-time versions of the EUM with K urns and N balls: with and without interactions between the balls in the same urn. We evaluate the probability distribution that the average number of balls in one urn over time T, , takes any specified value aN, where . For long observation time, , a Donsker–Varadhan large deviation principle holds: , where … denote additional parameters of the model. We calculate the rate function exactly by two different methods due to Donsker and Varadhan and compare the exact results with those obtained with a variant of WKB approximation (after Wentzel, Kramers and Brillouin). In the absence of interactions the WKB prediction for is exact for any N. In the presence of interactions the WKB method gives asymptotically exact results for . The WKB method also uncovers the (very simple) time history of the system which dominates the contribution of different time histories to .

The association of statin therapy with the risk of recurrent venous thrombosis.

PubMed

Smith, N L; Harrington, L B; Blondon, M; Wiggins, K L; Floyd, J S; Sitlani, C M; McKnight, B; Larson, E B; Rosendaal, F R; Heckbert, S R; Psaty, B M

2016-07-01

Essentials A lowered risk of recurrent venous thrombosis (VT) with statin treatment is controversial. Among observational inception cohort of 2,798 adults with incident VT, 457 had recurrent VT. Time-to-event models with time-varying statin use and adjustment for potential confounders was used for analysis. Compared to nonuse, current statin use was associated with 26% lower risk of recurrent VT. Click to hear Prof. Büller's perspective on Anticoagulant Therapy in the Treatment of Venous Thromboembolism Background Meta-analyses of randomized controlled trials suggest that treatment with hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) lowers the risk of incident venous thrombosis (VT), particularly among those without prevalent clinical cardiovascular disease (CVD). Whether this is true for the prevention of recurrent VT is debated. We used an observational inception cohort to estimate the association of current statin use with the risk of recurrent VT. Methods and Results The study setting was a large healthcare organization with detailed medical record and pharmacy information at cohort entry and throughout follow-up. We followed 2798 subjects 18-89 years of age who experienced a validated incident VT between January 1, 2002, and December 31, 2010, for a first recurrent VT, validated by medical record review. During follow-up, 457 (16%) developed a first recurrent VT. In time-to-event models incorporating time-varying statin use and adjusting for potential confounders, current statin use was associated with a 26% lower risk of recurrent VT: hazard ratio 0.74, 95% confidence interval 0.59-0.94. Among cohort members free of CVD (n = 2134), current statin use was also associated with a lower risk (38%) of recurrent VT: hazard ratio 0.62, 95% confidence interval 0.45-0.85. We found similar results when restricting to new users of statins and in subgroups of different statin types and doses. Conclusions In a population-based cohort of subjects who had experienced an incident VT, statin use, compared with nonuse, was associated with a clinically relevant lower risk of recurrent VT. These findings suggest a potential secondary benefit of statins among patients who have experienced an incident VT. © 2016 International Society on Thrombosis and Haemostasis.

75 FR 28668 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

... associations to act jointly in developing a national market system plan to create, implement, and maintain a consolidated audit trail that would capture customer and order event information, mostly in real time, for all orders in NMS securities, across all markets, from the time of order inception through routing...

USDA's Systematic Entomology Laboratory (SEL): Global leadership and innovation in insect systematics

USDA-ARS?s Scientific Manuscript database

A longstanding agreement between the USDA and the Smithsonian Institution created the National Insect Collection, one of the premiere entomological resources on the planet. Since its inception, USDA scientists associated with the National Insect Collection have been at the forefront of documenting i...

77 FR 68785 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

.... Program expenditures for the CHIP have increased since its inception; as such, CHIP receivables and..., effectiveness, and appropriateness of health care services and procedures to identify the manner in which... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare & Medicaid Services [Document...

IMPACT OF MAN ON THE COASTAL ENVIRONMENT

EPA Science Inventory

This volume represents EPA's effort to take stock of scientific advances in research pertaining to the coastal environment since the inception of the Agency and to gauge what progress has been made and what remains to be accomplished. The essays in this volume present a range of ...

An Audio-Visual Presentation of Black Francophone Poetry.

ERIC Educational Resources Information Center

Bruner, Charlotte H.

1982-01-01

A college class project to develop a videocassette presentation of African, Caribbean, and Afro-American French poetry is described from its inception through the processes of obtaining copyright and translation permissions, arranging scripts, presenting at various functions, and reception by Francophone and non-Francophone audiences. (MSE)

Managing Ongoing EVSE Costs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hodge, Cabell

The costs associated with EVSE begin with picking the best location and unit for the job, but they continue with electricity and network charges through the life of your vehicle. This presentation tells how to balance electricity demand charges and network management costs through smart planning at your program's inception.

"Mid-Week Pictorial": Pioneer American Photojournalism Magazine.

ERIC Educational Resources Information Center

Kenney, Keith

In 1914 (22 years before the inception of "Life" magazine), the "New York Times" began publishing "Mid-Week Pictorial" to absorb a flood of war pictures pouring in from Europe. Several sociological and technological forces shaped "Mid-Week Pictorial" as a pioneer of American photojournalism magazines,…

Public Expenditure on Education in the 1860s

ERIC Educational Resources Information Center

Morris, Norman

1977-01-01

A grant system for educational funding, the Revised Code, was initiated in England in 1862. This article investigates one of its criticisms--that it tended to cut down resources--by examining what happened to the cash flow and why in the years following its inception. (Author/ND)

Gearbox Reliability Collaborative Research | Wind | NREL

Science.gov Websites

inception, the Gearbox Reliability Collaborative (GRC) has collected an extraordinary amount of experimental torque, steady state and dynamic non-torque loads, internal loads and deflections, and condition important data and conclusions such as the importance of non-torque loads, dynamic torque events, planetary

Distributed Leadership of School Curriculum Change: An Integrative Approach

ERIC Educational Resources Information Center

Fasso, Wendy; Knight, Bruce Allen; Purnell, Ken

2016-01-01

Since its inception in 1999, the distributed leadership framework of Spillane, Halverson, and Diamond [2004. "Towards a Theory of Leadership Practice: A Distributed Perspective." "Journal of Curriculum Studies" 36 (1): 3-34. doi:10.1080/0022027032000106726] has supported research into leadership and change in schools. Whilst…

Developing the sediment and erosion control laboratory to become a hands-on training and education center.

DOT National Transportation Integrated Search

2013-11-01

The Sedimentation and Erosion Control (SEC) Laboratory has an established reputation as a renowned soil erosion research facility in the United States since its inception in 1990. During the past two decades, the lab has expanded its original perform...

A Concurrent Support Course for Intermediate Algebra

ERIC Educational Resources Information Center

Cooper, Cameron I.

2011-01-01

This article summarizes the creation and implementation of a concurrent support class for TRS 92--Intermediate Algebra, a developmental mathematics course at Fort Lewis College in Durango, Colorado. The concurrent course outlined in this article demonstrates a statistically significant increase in student success rates since its inception.…

Prospective Higher Education Providers

ERIC Educational Resources Information Center

Australian Government Tertiary Education Quality and Standards Agency, 2016

2016-01-01

Since the inception of the Australian Government Tertiary Education Quality and Standards Agency (TEQSA) in January 2012, 106 organisations have submitted or indicated their intention to submit applications for initial registration to TEQSA. Of those who have submitted applications, 2 have been rejected, 10 have subsequently been withdrawn by the…

We're Engaged! A Community-University Library Collaboration

ERIC Educational Resources Information Center

Rolloff, Evelyn K.

2013-01-01

Since its inception, Metropolitan State University has demonstrated a strong commitment to community partnerships and the integration of community engagement into student learning and scholarship while meeting community-defined needs. This article presents examples of reciprocal partnerships in the context of a shared community-university library…

Remote Teacher Observation at the University of Kentucky

ERIC Educational Resources Information Center

Hager, Karen D.; Baird, Constance M.; Spriggs, Amy D.

2012-01-01

Faculty and staff from three university departments (Special Education, Distance Learning Programs, and Distance Learning Networks) collaborated to develop a system for remote observation of student teachers. Colleges across the campus currently use the system. The development process from inception to implementation is described, and the specific…

Genetic fingerprinting of potato varieties from the Northwest Potato Variety Development Program

USDA-ARS?s Scientific Manuscript database

The Northwest Potato Variety Development Program using conventional breeding has successfully released more than 40 improved varieties of potato since its inception in 1983. Potato breeders rely primarily on morphological and phenotypic data for selection and breeding of potato cultivars. With the a...

Empowering Young People through Service

ERIC Educational Resources Information Center

Kapp, Amy

2009-01-01

Each year, more than 200 students at YouthBuild Philadelphia Charter School in Pennsylvania make a commitment to help improve Philadelphia's neighborhoods as they work toward their high school diplomas. Since YouthBuild Philadelphia's inception in 1992, students have provided a wide variety of volunteer services to families and organizations…

TEANGA: Journal of the Irish Association for Applied Linguistics, 1979-1993.

ERIC Educational Resources Information Center

O'Baoill, Donall P., Ed.

1993-01-01

This document consists of a complete run of the thirteen issues of "TEANGA" published since its inception in 1979 through 1993. Typical article topics include: linguistic research approaches and methodology; interlanguage, language transfer, and interference; second language instruction; language testing; language variation; discussion…

The Hand Test: Fifteen Years Later

ERIC Educational Resources Information Center

Hoover, Thomas O.

1978-01-01

The Hand Test, a projective device involving drawings of hands in semi-ambiguous poses, has increased in popularity among clinical and school psychologists in the 15 years since its inception. Research on the test is reviewed and its merit in clinical and diverse assessment situations is discussed. (Author/JAC)

The Language Testing Cycle: From Inception to Washback. Series S, Number 13.

ERIC Educational Resources Information Center

Wigglesworth, Gillian, Ed.; Elder, Catherine, Ed.

A selection of essays on language testing includes: "Perspectives on the Testing Cycle: Setting the Scene" (Catherine Elder, Gillian Wigglesworth); "The Politicisation of English: The Case of the STEP Test and the Chinese Students" (Lesleyanne Hawthorne); "Developing Language Tests for Specific Populations" (Rosemary…

Project Management as Related to Weapon Development in Navy Research and Development Organizations.

DTIC Science & Technology

of management . AGILE a current development program, is traced from inception to the present and unique management problems are discussed. The authors...evaluation is based on two standards of measurement: compliance with Department of Defense policy and conformance to generally accepted principles

Clinical prediction models for mortality and functional outcome following ischemic stroke: A systematic review and meta-analysis

PubMed Central

Crayton, Elise; Wolfe, Charles; Douiri, Abdel

2018-01-01

Objective We aim to identify and critically appraise clinical prediction models of mortality and function following ischaemic stroke. Methods Electronic databases, reference lists, citations were searched from inception to September 2015. Studies were selected for inclusion, according to pre-specified criteria and critically appraised by independent, blinded reviewers. The discrimination of the prediction models was measured by the area under the curve receiver operating characteristic curve or c-statistic in random effects meta-analysis. Heterogeneity was measured using I2. Appropriate appraisal tools and reporting guidelines were used in this review. Results 31395 references were screened, of which 109 articles were included in the review. These articles described 66 different predictive risk models. Appraisal identified poor methodological quality and a high risk of bias for most models. However, all models precede the development of reporting guidelines for prediction modelling studies. Generalisability of models could be improved, less than half of the included models have been externally validated(n = 27/66). 152 predictors of mortality and 192 predictors and functional outcome were identified. No studies assessing ability to improve patient outcome (model impact studies) were identified. Conclusions Further external validation and model impact studies to confirm the utility of existing models in supporting decision-making is required. Existing models have much potential. Those wishing to predict stroke outcome are advised to build on previous work, to update and adapt validated models to their specific contexts opposed to designing new ones. PMID:29377923

A reference time scale for Site U1385 (Shackleton Site) on the SW Iberian Margin

NASA Astrophysics Data System (ADS)

Hodell, D.; Lourens, L.; Crowhurst, S.; Konijnendijk, T.; Tjallingii, R.; Jiménez-Espejo, F.; Skinner, L.; Tzedakis, P. C.; Abrantes, Fatima; Acton, Gary D.; Alvarez Zarikian, Carlos A.; Bahr, André; Balestra, Barbara; Barranco, Estefanìa Llave; Carrara, Gabriela; Ducassou, Emmanuelle; Flood, Roger D.; Flores, José-Abel; Furota, Satoshi; Grimalt, Joan; Grunert, Patrick; Hernández-Molina, Javier; Kim, Jin Kyoung; Krissek, Lawrence A.; Kuroda, Junichiro; Li, Baohua; Lofi, Johanna; Margari, Vasiliki; Martrat, Belen; Miller, Madeline D.; Nanayama, Futoshi; Nishida, Naohisa; Richter, Carl; Rodrigues, Teresa; Rodríguez-Tovar, Francisco J.; Roque, Ana Cristina Freixo; Sanchez Goñi, Maria F.; Sierro Sánchez, Francisco J.; Singh, Arun D.; Sloss, Craig R.; Stow, Dorrik A. V.; Takashimizu, Yasuhiro; Tzanova, Alexandrina; Voelker, Antje; Xuan, Chuang; Williams, Trevor

2015-10-01

We produced a composite depth scale and chronology for Site U1385 on the SW Iberian Margin. Using log(Ca/Ti) measured by core scanning XRF at 1-cm resolution in all holes, a composite section was constructed to 166.5 meter composite depth (mcd) that corrects for stretching and squeezing in each core. Oxygen isotopes of benthic foraminifera were correlated to a stacked δ18O reference signal (LR04) to produce an oxygen isotope stratigraphy and age model. Variations in sediment color contain very strong precession signals at Site U1385, and the amplitude modulation of these cycles provides a powerful tool for developing an orbitally-tuned age model. We tuned the U1385 record by correlating peaks in L* to the local summer insolation maxima at 37°N. The benthic δ18O record of Site U1385, when placed on the tuned age model, generally agrees with other time scales within their respective chronologic uncertainties. The age model is transferred to down-core data to produce a continuous time series of log(Ca/Ti) that reflect relative changes of biogenic carbonate and detrital sediment. Biogenic carbonate increases during interglacial and interstadial climate states and decreases during glacial and stadial periods. Much of the variance in the log(Ca/Ti) is explained by a linear combination of orbital frequencies (precession, tilt and eccentricity), whereas the residual signal reflects suborbital climate variability. The strong correlation between suborbital log(Ca/Ti) variability and Greenland temperature over the last glacial cycle at Site U1385 suggests that this signal can be used as a proxy for millennial-scale climate variability over the past 1.5 Ma. Millennial climate variability, as expressed by log(Ca/Ti) at Site U1385, was a persistent feature of glacial climates over the past 1.5 Ma, including glacial periods of the early Pleistocene ('41-kyr world') when boundary conditions differed significantly from those of the late Pleistocene ('100-kyr world'). Suborbital variability was suppressed during interglacial stages and enhanced during glacial periods, especially when benthic δ18O surpassed 3.3-3.5‰. Each glacial inception was marked by appearance of strong millennial variability and each deglaciation was preceded by a terminal stadial event. Suborbital variability may be a symptomatic feature of glacial climate or, alternatively, may play a more active role in the inception and/or termination of glacial cycles.

The flares of August 1972. [solar flare characteristics and spectra

NASA Technical Reports Server (NTRS)

Zirin, H.; Tanaka, K.

1973-01-01

Observations of the August, 1972 flares at Big Bear and Tel Aviv, involving monochromatic movies, magnetograms, and spectra, are analyzed. The region (McMath 11976) showed inverted polarity from its inception on July 11; the great activity was due to extremely high shear and gradients in the magnetic field, as well as a constant invasion of one polarity into the opposite; observations in lambda 3835 show remarkable fast flashes in the impulsive flare of 18:38 UT on Aug. 2 with lifetimes of 5 sec, which may be due to dumping of particles in the lower chromosphere. Flare loops show evolutionary increases of their tilts to the neutral line in the flares of Aug. 4 and 7. Spectroscopic observations show red asymmetry and red shift of the H alpha emission in the flash phase of the Aug. 7 flare, as well as substantial velocity shear in the photosphere during the flare, somewhat like earthquake movement along a fault. Finally the total H alpha emission of the Aug. 7 flare could be measured accurately as about 2.5 x 10 to the 30th power erg, considerably less than coarser previous estimates for great flares.

When a water drop freezes before it solidifies

NASA Astrophysics Data System (ADS)

Kavehpour, Pirouz; Davis, Stephen; Tavakoli, Faryar

2012-11-01

When a drop of liquid is placed on a substrate which temperature is below the melting point of the liquid, one would expect the drop to solidify instantaneously. However, many liquids, such as water, must be subcooled to solidify below its melting temperature due to homogeneous nucleation's high activation energy. Most of the drop solidification research, particularly for water, phase change is assumed to occur at equilibrium freezing temperature; however, this is not the case. We found that after a certain degree of supercooling, a kinetic based nucleation begins and latent heat of fusion is suddenly liberated, causing an increase in liquid temperature. At the end of this stage, approximately 20% of the drop is crystallized. This phenomenon is known among metallurgists as recalescence. This is followed by a slow solidification process at the melting point. As a water droplet spreads on a cold substrate, its contact line stops just prior to freezing inception from the liquid-solid interface. In this study, we assert that recalescence prior to solidification may be the cause of water's sudden immobility, which results in a fixed contact angle and droplet diameter. In our experiments, the nucleation front initiates from the trijunction point and propagates to the drop volume.

Implementing the 4D cycle of appreciative inquiry in health care: a methodological review.

PubMed

Trajkovski, Suza; Schmied, Virginia; Vickers, Margaret; Jackson, Debra

2013-06-01

To examine and critique how the phases of the 4D cycle (Discovery, Dream, Design, and Destiny) of appreciative inquiry are implemented in a healthcare context. Appreciative inquiry is a theoretical research perspective, an emerging research methodology and a world view that builds on action research, organizational learning, and organizational change. Increasing numbers of articles published provide insights and learning into its theoretical and philosophical underpinnings. Many articles describe appreciative inquiry and the outcomes of their studies; however, there is a gap in the literature examining the approaches commonly used to implement the 4D cycle in a healthcare context. A methodological review following systematic principles. A methodological review was conducted including articles from the inception of appreciative inquiry in 1986 to the time of writing this review in November, 2011. Key database searches included CINAHL, Emerald, MEDLINE, PubMed, PsycINFO, and Scopus. A methodological review following systematic principles was undertaken. Studies were included if they described in detail the methods used to implement the 4D cycle of appreciative inquiry in a healthcare context. Nine qualitative studies met the inclusion criteria. Results highlighted that appreciative inquiry application is unique and varied between studies. The 4D phases were not rigid steps and were adapted to the setting and participants. Overall, participant enthusiasm and commitment were highlighted suggesting appreciative inquiry was mostly positively perceived by participants. Appreciative inquiry provides a positive way forward shifting from problems to solutions offering a new way of practicing in health care and health research. © 2012 Blackwell Publishing Ltd.

Shed vortex structure and phase-averaged velocity statistics in symmetric/asymmetric turbulent flat plate wakes

NASA Astrophysics Data System (ADS)

Rai, Man Mohan

2018-05-01

The near wake of a flat plate is investigated via direct numerical simulations. Many earlier experimental investigations have used thin plates with sharp trailing edges and turbulent boundary layers to create the wake. This results in large θ/DTE values (θ is the boundary layer momentum thickness toward the end of the plate and DTE is the trailing edge thickness). In the present study, the emphasis is on relatively thick plates with circular trailing edges (CTEs) resulting in θ/D values less than one (D is the plate thickness and the diameter of the CTE) and vigorous vortex shedding. The Reynolds numbers based on the plate length and D are 1.255 × 106 and 10 000, respectively. Two cases are computed: one with turbulent boundary layers on both the upper and lower surfaces of the plate (statistically the same, symmetric wake, Case TT) and the other with turbulent and laminar boundary layers on the upper and lower surfaces, respectively (asymmetric case, Case TL). The data and understanding obtained are of considerable engineering interest, particularly in turbomachinery where the pressure side of an airfoil can remain laminar or transitional because of a favorable pressure gradient and the suction side is turbulent. Shed-vortex structure and phase-averaged velocity statistics obtained in the two cases are compared here. The upper negative shed vortices in Case TL (turbulent separating boundary layer) are weaker than the lower positive ones (laminar separating boundary layer) at inception (a factor of 1.27 weaker in terms of peak phase-averaged spanwise vorticity at the first appearance of a peak). The upper vortices weaken rapidly as they travel downstream. A second feature of interest in Case TL is a considerable increase in the peak phase-averaged, streamwise normal intensity (random component) with increasing streamwise distance (x/D) that occurs near the positive vortex cores. This behavior is observed for a few diameters in the near wake. This is counter to Case TT where the peak value essentially decreases with increasing x/D. Both these effects are examined in detail, and the important contributors are identified.

ORDEM 3.0 and MASTER-2009 Modeled Small Debris Population Comparison

NASA Technical Reports Server (NTRS)

Krisko, P. H.; Flegel, S.

2012-01-01

The latest versions of the two premier orbital debris engineering models, NASA's ORDEM 3.0 and ESA's MASTER-2009, have been publicly released within the last year. Both models have gone through significant advancements since inception, and now represent the state-of-the-art in orbital debris knowledge of their respective agencies. The purpose of these models is to provide satellite designers/operators and debris researchers with reliable estimates of the artificial debris environment in near-Earth orbit. The small debris environment within the size range of 1 mm to 1 cm is of particular interest to both human and robotic spacecraft programs. These objects are much more numerous than larger trackable debris but are still large enough to cause significant, if not catastrophic, damage to spacecraft upon impact. They are also small enough to elude routine detection by existing observation systems (radar and telescope). Without reliable detection the modeling of these populations has always coupled theoretical origins with supporting observational data in different degrees. This paper describes the population generation and categorization of both ORDEM 3.0 and MASTER-2009; their sources (both known and presumed), current supporting data and theory, and methods of population verification. Fluxes on spacecraft for chosen orbits are presented and discussed. Future collaborative analysis is noted.

Analysis of turbulence and surface growth models on the estimation of soot level in ethylene non-premixed flames

NASA Astrophysics Data System (ADS)

Yunardi, Y.; Munawar, Edi; Rinaldi, Wahyu; Razali, Asbar; Iskandar, Elwina; Fairweather, M.

2018-02-01

Soot prediction in a combustion system has become a subject of attention, as many factors influence its accuracy. An accurate temperature prediction will likely yield better soot predictions, since the inception, growth and destruction of the soot are affected by the temperature. This paper reported the study on the influences of turbulence closure and surface growth models on the prediction of soot levels in turbulent flames. The results demonstrated that a substantial distinction was observed in terms of temperature predictions derived using the k-ɛ and the Reynolds stress models, for the two ethylene flames studied here amongst the four types of surface growth rate model investigated, the assumption of the soot surface growth rate proportional to the particle number density, but independent on the surface area of soot particles, f ( A s ) = ρ N s , yields in closest agreement with the radial data. Without any adjustment to the constants in the surface growth term, other approaches where the surface growth directly proportional to the surface area and square root of surface area, f ( A s ) = A s and f ( A s ) = √ A s , result in an under- prediction of soot volume fraction. These results suggest that predictions of soot volume fraction are sensitive to the modelling of surface growth.

Impact of comorbidities on stroke rehabilitation outcomes: does the method matter?

PubMed

Berlowitz, Dan R; Hoenig, Helen; Cowper, Diane C; Duncan, Pamela W; Vogel, W Bruce

2008-10-01

To examine the impact of comorbidities in predicting stroke rehabilitation outcomes and to examine differences among 3 commonly used comorbidity measures--the Charlson Index, adjusted clinical groups (ACGs), and diagnosis cost groups (DCGs)--in how well they predict these outcomes. Inception cohort of patients followed for 6 months. Department of Veterans Affairs (VA) hospitals. A total of 2402 patients beginning stroke rehabilitation at a VA facility in 2001 and included in the Integrated Stroke Outcomes Database. Not applicable. Three outcomes were evaluated: 6-month mortality, 6-month rehospitalization, and change in FIM score. During 6 months of follow-up, 27.6% of patients were rehospitalized and 8.6% died. The mean FIM score increased an average of 20 points during rehabilitation. Addition of comorbidities to the age and sex models improved their performance in predicting these outcomes based on changes in c statistics for logistic and R(2) values for linear regression models. While ACG and DCG models performed similarly, the best models, based on DCGs, had a c statistic of .74 for 6-month mortality and .63 for 6-month rehospitalization, and an R(2) of .111 for change in FIM score. Comorbidities are important predictors of stroke rehabilitation outcomes. How they are classified has important implications for models that may be used in assessing quality of care.