Chapter 1: Creating Opportunities for Success through Replacement Services. Chapter 1 Replacement Class Collaborative Teaming and Intensive Teaching Time. A Model for Student Success in Newark City Schools.

ERIC Educational Resources Information Center

Stout, Kathleen

This collection of documents describes the Chapter 1 programs of the Newark (Ohio) City Schools and presents a model for programs to increase student success. Newark is a midsized city district with 1 high school, 3 middle schools, and 12 elementary schools, 7 of which receive Chapter 1 services. Collaborative efforts include replacement classes.…

Development of a model for predicting NASA/MSFC program success

NASA Technical Reports Server (NTRS)

Riggs, Jeffrey; Miller, Tracy; Finley, Rosemary

1990-01-01

Research conducted during the execution of a previous contract (NAS8-36955/0039) firmly established the feasibility of developing a tool to aid decision makers in predicting the potential success of proposed projects. The final report from that investigation contains an outline of the method to be applied in developing this Project Success Predictor Model. As a follow-on to the previous study, this report describes in detail the development of this model and includes full explanation of the data-gathering techniques used to poll expert opinion. The report includes the presentation of the model code itself.

Cooperative Teaching: A Model for Teacher Collaboration.

ERIC Educational Resources Information Center

Bohlmann, Natalie L.

1998-01-01

A third grade teacher examines the effects of cooperative teaching in a two-teacher classroom. After discussing teacher roles in such classrooms, the paper describes how the advantages of such a system greatly outweigh the disadvantages. The paper presents keys to a successful teaching partnership and describes several models for lesson…

A dynamic model for tumour growth and metastasis formation.

PubMed

Haustein, Volker; Schumacher, Udo

2012-07-05

A simple and fast computational model to describe the dynamics of tumour growth and metastasis formation is presented. The model is based on the calculation of successive generations of tumour cells and enables one to describe biologically important entities like tumour volume, time point of 1st metastatic growth or number of metastatic colonies at a given time. The model entirely relies on the chronology of these successive events of the metastatic cascade. The simulation calculations were performed for two embedded growth models to describe the Gompertzian like growth behaviour of tumours. The initial training of the models was carried out using an analytical solution for the size distribution of metastases of a hepatocellular carcinoma. We then show the applicability of our models to clinical data from the Munich Cancer Registry. Growth and dissemination characteristics of metastatic cells originating from cells in the primary breast cancer can be modelled thus showing its ability to perform systematic analyses relevant for clinical breast cancer research and treatment. In particular, our calculations show that generally metastases formation has already been initiated before the primary can be detected clinically.

A dynamic model for tumour growth and metastasis formation

PubMed Central

2012-01-01

A simple and fast computational model to describe the dynamics of tumour growth and metastasis formation is presented. The model is based on the calculation of successive generations of tumour cells and enables one to describe biologically important entities like tumour volume, time point of 1st metastatic growth or number of metastatic colonies at a given time. The model entirely relies on the chronology of these successive events of the metastatic cascade. The simulation calculations were performed for two embedded growth models to describe the Gompertzian like growth behaviour of tumours. The initial training of the models was carried out using an analytical solution for the size distribution of metastases of a hepatocellular carcinoma. We then show the applicability of our models to clinical data from the Munich Cancer Registry. Growth and dissemination characteristics of metastatic cells originating from cells in the primary breast cancer can be modelled thus showing its ability to perform systematic analyses relevant for clinical breast cancer research and treatment. In particular, our calculations show that generally metastases formation has already been initiated before the primary can be detected clinically. PMID:22548735

A Comprehensive Career-Success Model for Physician-Scientists

PubMed Central

Rubio, Doris M.; Primack, Brian A.; Switzer, Galen E.; Bryce, Cindy L.; Seltzer, Deborah L.; Kapoor, Wishwa N.

2011-01-01

With today’s focus on the translation of basic science discoveries into clinical practice, the demand for physician-scientists is growing. Yet, physicians have always found it challenging to juggle the demands of clinical care with the time required to perform research. The Research on Careers Workgroup of the Institute for Clinical Research Education at the University of Pittsburgh developed a comprehensive model for career success that would address, and allow for the evaluation of, the personal factors, organizational factors, and their interplay that contribute to career success. With this model, leaders of training programs could identify early opportunities for intervening with potential physician-scientists to ensure career success. Through an iterative process described in this article, the authors identified and examined potential models for career success from the literature, added other elements determined to be significant, and developed a comprehensive model to assess factors associated with career success for physician-scientists. The authors also present examples of ways in which this model can be adapted and applied to specific situations to assess the effects of different factors on career success. PMID:22030759

A comprehensive career-success model for physician-scientists.

PubMed

Rubio, Doris M; Primack, Brian A; Switzer, Galen E; Bryce, Cindy L; Seltzer, Deborah L; Kapoor, Wishwa N

2011-12-01

With today's focus on the translation of basic science discoveries into clinical practice, the demand for physician-scientists is growing. Yet, physicians have always found it challenging to juggle the demands of clinical care with the time required to perform research. The Research on Careers Workgroup of the Institute for Clinical Research Education at the University of Pittsburgh developed a comprehensive model for career success that would address, and allow for the evaluation of, the personal factors, organizational factors, and their interplay that contribute to career success. With this model, leaders of training programs could identify early opportunities for intervening with potential physician-scientists to ensure career success. Through an iterative process described in this article, the authors identified and examined potential models for career success from the literature, added other elements determined to be significant, and developed a comprehensive model to assess factors associated with career success for physician-scientists. The authors also present examples of ways in which this model can be adapted and applied to specific situations to assess the effects of different factors on career success.

Lessons learned from a one-dimensional water quality model for the Gulf of Mexico

EPA Science Inventory

Hypoxia in the northern Gulf of Mexico has been a major concern for many years. Several water quality models have attempted to describe the link between high nutrient loads from the Mississippi River and hypoxia in the Gulf of Mexico with varied success. Here we describe the dev...

Do's and Don'ts of Computer Models for Planning

ERIC Educational Resources Information Center

Hammond, John S., III

1974-01-01

Concentrates on the managerial issues involved in computer planning models. Describes what computer planning models are and the process by which managers can increase the likelihood of computer planning models being successful in their organizations. (Author/DN)

Community College/High School Feedback and Collaboration: Preventative Measures.

ERIC Educational Resources Information Center

Richey, Deborah K.; Mathern, Jeanette; O'Shea, Carol S.; Pierce, Shelby J.

1997-01-01

Describes a successful collaboration between high school and community college faculty that effected a reduced need for first-time college student remedial writing instruction. Discusses Ohio's Early English Composition Assessment Program, the model for collaborative success, and project recommendations. (YKH)

A model for successful use of student response systems.

PubMed

Klein, Kathleen; Kientz, Mary

2013-01-01

This article presents a model developed to assist teachers in selecting, implementing, and assessing student response system (SRS) use in the classroom. Research indicates that SRS technology is effective in achieving desired outcomes in higher education settings. Studies indicate that effective SRS use promotes greater achievement of learning outcomes, increased student attention, improved class participation, and active engagement. The model offered in this article is based on best practices described in the literature and several years of SRS use in a traditional higher education classroom setting. Student feedback indicates increased class participation and engagement with SRS technology. Teacher feedback indicates opportunities for contingent teaching. The model described in this article provides a process to assist teachers in the successful selection, implementation, and assessment of SRS technology in the classroom.

Succession planning: securing the future.

PubMed

Bolton, Julia; Roy, Wendy

2004-12-01

Succession planning is an essential business strategy for healthcare organizations, given the impending retirement of the huge Baby Boomer cohort of experienced nurses. It ensures that there will be qualified candidates when key vacancies occur. The authors describe the critical elements of a succession plan and suggest ways to implement them. The model can be applied to leadership and clinical positions.

Learner Diversity: A Successful Blended Professional Learning Approach Promoting Quality Inclusion in the United Kingdom and New South Wales, Australia

ERIC Educational Resources Information Center

Clench, Hugh; King, Brian Smyth

2014-01-01

This paper describes the development of an online training model for teachers and teaching assistants working with students with special educational needs. Originally developed as part of a government funded initiative in the UK, the model has been successfully applied in other contexts, most notably in New South Wales, Australia where it has had…

The benefits of frequent positive affect: does happiness lead to success?

PubMed

Lyubomirsky, Sonja; King, Laura; Diener, Ed

2005-11-01

Numerous studies show that happy individuals are successful across multiple life domains, including marriage, friendship, income, work performance, and health. The authors suggest a conceptual model to account for these findings, arguing that the happiness-success link exists not only because success makes people happy, but also because positive affect engenders success. Three classes of evidence--crosssectional, longitudinal, and experimental--are documented to test their model. Relevant studies are described and their effect sizes combined meta-analytically. The results reveal that happiness is associated with and precedes numerous successful outcomes, as well as behaviors paralleling success. Furthermore, the evidence suggests that positive affect--the hallmark of well-being--may be the cause of many of the desirable characteristics, resources, and successes correlated with happiness. Limitations, empirical issues, and important future research questions are discussed.

The Standard Model.

PubMed

Shears, Tara

2012-02-28

The Standard Model is the theory used to describe the interactions between fundamental particles and fundamental forces. It is remarkably successful at predicting the outcome of particle physics experiments. However, the theory has not yet been completely verified. In particular, one of the most vital constituents, the Higgs boson, has not yet been observed. This paper describes the Standard Model, the experimental tests of the theory that have led to its acceptance and its shortcomings.

Minding the Business of Business: Tools and Models to Design and Measure Wealth Creation

ERIC Educational Resources Information Center

Bernardez, Mariano L.

2009-01-01

What is the business of business? How can planners and investors anticipate the true chances of failure and success of a business idea? This article describes a rationale for developing successful new business on the basis of a simple, sensible idea: the business of any business is to make its clients successful enough to continue purchasing and…

The development of a successful physician compensation plan.

PubMed

Berkowitz, Steven M

2002-10-01

Physician compensation plans are critical to the success of a physician group or may lead to the demise of the group. Essential components of the development and implementation of a successful physician compensation plan include: strategic planning, physician understanding and buy-in, appropriate incentives, objective performance measurement, and a specific funding source or mechanism. There are two basic philosophies to consider for use: the market-based model and the net economic contribution model. Advantages and disadvantages of each are discussed. Methods of incorporating these multiple aspects into a single plan are described.

A Model Midshipman: Factors Related to Academic and Military Success of Prior Enlisted Midshipmen at the United States Naval Academy

DTIC Science & Technology

2005-06-01

Perceived Career Success , Commitment and Turnover Intentions. The Journal of American Academy of Business, Cambridge, 164-170. 22 undergone an...organizational commitment and career success and longevity, which was described earlier.40 One key to all of the opportunities for development presented...2004, September) The Effects of Mentoring on Perceived Career Success , Commitment and Turnover Intentions. The Journal of American Academy of

Description of Success: A Four-Teacher Instructional Model.

ERIC Educational Resources Information Center

Reed, Dianne

This study described a four-teacher instructional model in operation at an elementary school, noting the perceptions of fourth grade students, parents, and teachers regarding the model. The model encompassed teaming, block scheduling, departmentalization of subjects, integrated/interdisciplinary instruction, and in-depth instruction in each…

Procedures for Geometric Data Reduction in Solid Log Modelling

Treesearch

Luis G. Occeña; Wenzhen Chen; Daniel L. Schmoldt

1995-01-01

One of the difficulties in solid log modelling is working with huge data sets, such as those that come from computed axial tomographic imaging. Algorithmic procedures are described in this paper that have successfully reduced data without sacrificing modelling integrity.

Stochastic GARCH dynamics describing correlations between stocks

NASA Astrophysics Data System (ADS)

Prat-Ortega, G.; Savel'ev, S. E.

2014-09-01

The ARCH and GARCH processes have been successfully used for modelling price dynamics such as stock returns or foreign exchange rates. Analysing the long range correlations between stocks, we propose a model, based on the GARCH process, which is able to describe the main characteristics of the stock price correlations, including the mean, variance, probability density distribution and the noise spectrum.

The Many Faces of School-University Collaboration: Characteristics of Successful Partnerships.

ERIC Educational Resources Information Center

Ravid, Ruth, Ed.; Handler, Marianne G., Ed.

This book is designed to help educators entering into school-university collaborative relationships have a clearer picture of conditions that drive successful partnerships. The models described include collaboration between a university and professional development school, consultation, one-to-one collaborations, and multiple collaboration…

Radiation Models

ERIC Educational Resources Information Center

James, W. G. G.

1970-01-01

Discusses the historical development of both the wave and the corpuscular photon model of light. Suggests that students should be informed that the two models are complementary and that each model successfully describes a wide range of radiation phenomena. Cites 19 references which might be of interest to physics teachers and students. (LC)

Model comparison for Escherichia coli growth in pouched food.

PubMed

Fujikawa, Hiroshi; Yano, Kazuyoshi; Morozumi, Satoshi

2006-06-01

We recently studied the growth characteristics of Escherichia coli cells in pouched mashed potatoes (Fujikawa et al., J. Food Hyg. Soc. Japan, 47, 95-98 (2006)). Using those experimental data, in the present study, we compared a logistic model newly developed by us with the modified Gompertz and the Baranyi models, which are used as growth models worldwide. Bacterial growth curves at constant temperatures in the range of 12 to 34 degrees C were successfully described with the new logistic model, as well as with the other models. The Baranyi gave the least error in cell number and our model gave the least error in the rate constant and the lag period. For dynamic temperature, our model successfully predicted the bacterial growth, whereas the Baranyi model considerably overestimated it. Also, there was a discrepancy between the growth curves described with the differential equations of the Baranyi model and those obtained with DMfit, a software program for Baranyi model fitting. These results indicate that the new logistic model can be used to predict bacterial growth in pouched food.

Modeling and applications in microbial food safety

USDA-ARS?s Scientific Manuscript database

Mathematical modeling is a scientific and systematic approach to study and describe the recurrent events or phenomena with successful application track for decades. When models are properly developed and validated, their applications may save costs and time. For the microbial food safety concerns, ...

Scaling Up Success: Lessons Learned from Technology-Based Educational Improvement

ERIC Educational Resources Information Center

Dede, Chris, Ed.; Honan, James P., Ed.; Peters, Laurence C., Ed.

2005-01-01

Drawing from the information presented at a conference sponsored by the Harvard Graduate School of Education and the Mid-Atlantic Regional Technology in Education Consortium, educators, researchers, and policymakers translate theory into practice to provide a hands-on resource that describes different models for scaling up success. This resource…

Spatial simulation of forest succession and timber harvesting using LANDIS

Treesearch

Eric J. Gustafson; Stephen R. Shifley; David J. Mladenoff; Kevin K. Nimerfro; Hong S. He

2000-01-01

The LANDIS model simulates ecological dynamics, including forest succession, disturbance, seed dispersal and establishment, fire and wind disturbance, and their interactions. We describe the addition to LANDIS of capabilities to simulate forest vegetation management, including harvest. Stands (groups of cells) are prioritized for harvest using one of four ranking...

Two Undergraduate Process Modeling Courses Taught Using Inductive Learning Methods

ERIC Educational Resources Information Center

Soroush, Masoud; Weinberger, Charles B.

2010-01-01

This manuscript presents a successful application of inductive learning in process modeling. It describes two process modeling courses that use inductive learning methods such as inquiry learning and problem-based learning, among others. The courses include a novel collection of multi-disciplinary complementary process modeling examples. They were…

Interventions in Early Mathematics: Avoiding Pollution and Dilution.

PubMed

Sarama, Julie; Clements, Douglas H

2017-01-01

Although specific interventions in early mathematics have been successful, few have been brought to scale successfully, especially across the challenging diversity of populations and contexts in the early childhood system in the United States. In this chapter, we analyze a theoretically based scale-up model for early mathematics that was designed to avoid the pollution and dilution that often plagues efforts to achieve broad success. We elaborate the theoretical framework by noting the junctures that are susceptible to dilution or pollution. Then we expatiate the model's guidelines to describe specifically how they were designed and implemented to mitigate pollution and dilution. Finally, we provide evidence regarding the success of these efforts. © 2017 Elsevier Inc. All rights reserved.

Modeling Surface Growth of Escherichia coli on Agar Plates

PubMed Central

Fujikawa, Hiroshi; Morozumi, Satoshi

2005-01-01

Surface growth of Escherichia coli cells on a membrane filter placed on a nutrient agar plate under various conditions was studied with a mathematical model. The surface growth of bacterial cells showed a sigmoidal curve with time on a semilogarithmic plot. To describe it, a new logistic model that we presented earlier (H. Fujikawa et al., Food Microbiol. 21:501-509, 2004) was modified. Growth curves at various constant temperatures (10 to 34°C) were successfully described with the modified model (model III). Model III gave better predictions of the rate constant of growth and the lag period than a modified Gompertz model and the Baranyi model. Using the parameter values of model III at the constant temperatures, surface growth at various temperatures was successfully predicted. Surface growth curves at various initial cell numbers were also sigmoidal and converged to the same maximum cell numbers at the stationary phase. Surface growth curves at various nutrient levels were also sigmoidal. The maximum cell number and the rate of growth were lower as the nutrient level decreased. The surface growth curve was the same as that in a liquid, except for the large curvature at the deceleration period. These curves were also well described with model III. The pattern of increase in the ATP content of cells grown on a surface was sigmoidal, similar to that for cell growth. We discovered several characteristics of the surface growth of bacterial cells under various growth conditions and examined the applicability of our model to describe these growth curves. PMID:16332768

Twelve years of succession on sandy substrates in a post-mining landscape: a Markov chain analysis.

PubMed

Baasch, Annett; Tischew, Sabine; Bruelheide, Helge

2010-06-01

Knowledge of succession rates and pathways is crucial for devising restoration strategies for highly disturbed ecosystems such as surface-mined land. As these processes have often only been described in qualitative terms, we used Markov models to quantify transitions between successional stages. However, Markov models are often considered not attractive for some reasons, such as model assumptions (e.g., stationarity in space and time, or the high expenditure of time required to estimate successional transitions in the field). Here we present a solution for converting multivariate ecological time series into transition matrices and demonstrate the applicability of this approach for a data set that resulted from monitoring the succession of sandy dry grassland in a post-mining landscape. We analyzed five transition matrices, four one-step matrices referring to specific periods of transition (1995-1998, 1998-2001, 2001-2004, 2004-2007), and one matrix for the whole study period (stationary model, 1995-2007). Finally, the stationary model was enhanced to a partly time-variable model. Applying the stationary and the time-variable models, we started a prediction well outside our calibration period, beginning with 100% bare soil in 1974 as the known start of the succession, and generated the coverage of 12 predefined vegetation types in three-year intervals. Transitions among vegetation types changed significantly in space and over time. While the probability of colonization was almost constant over time, the replacement rate tended to increase, indicating that the speed of succession accelerated with time or fluctuations became stronger. The predictions of both models agreed surprisingly well with the vegetation data observed more than two decades later. This shows that our dry grassland succession in a post-mining landscape can be adequately described by comparably simple types of Markov models, although some model assumptions have not been fulfilled and within-plot transitions have not been observed with point exactness. The major achievement of our proposed way to convert vegetation time series into transition matrices is the estimation of probability of events--a strength not provided by other frequently used statistical methods in vegetation science.

A Taoist Paradigm of EAP Consultation.

ERIC Educational Resources Information Center

Gerstein, Lawrence H.; Sturmer, Paul

1993-01-01

Describes new Taoist model as alternative approach to conceptualizing consultation process and to formulating successful, isomorphic interventions constructed to facilitate four change processes. Presents model stressing importance of interrelationships between individuals and groups; integrating repulsion and assimilation forces; balancing human…

Value of Information and Information Services

DOT National Transportation Integrated Search

1975-10-01

The report describes the salient features of the SCOT (Simulation of Corridor Traffic) model and a successful calibration and validation. SCOT is a computer model that may be applied to an urban traffic corridor and will simulate vehicular traffic on...

BioMOL: a computer-assisted biological modeling tool for complex chemical mixtures and biological processes at the molecular level.

PubMed Central

Klein, Michael T; Hou, Gang; Quann, Richard J; Wei, Wei; Liao, Kai H; Yang, Raymond S H; Campain, Julie A; Mazurek, Monica A; Broadbelt, Linda J

2002-01-01

A chemical engineering approach for the rigorous construction, solution, and optimization of detailed kinetic models for biological processes is described. This modeling capability addresses the required technical components of detailed kinetic modeling, namely, the modeling of reactant structure and composition, the building of the reaction network, the organization of model parameters, the solution of the kinetic model, and the optimization of the model. Even though this modeling approach has enjoyed successful application in the petroleum industry, its application to biomedical research has just begun. We propose to expand the horizons on classic pharmacokinetics and physiologically based pharmacokinetics (PBPK), where human or animal bodies were often described by a few compartments, by integrating PBPK with reaction network modeling described in this article. If one draws a parallel between an oil refinery, where the application of this modeling approach has been very successful, and a human body, the individual processing units in the oil refinery may be considered equivalent to the vital organs of the human body. Even though the cell or organ may be much more complicated, the complex biochemical reaction networks in each organ may be similarly modeled and linked in much the same way as the modeling of the entire oil refinery through linkage of the individual processing units. The integrated chemical engineering software package described in this article, BioMOL, denotes the biological application of molecular-oriented lumping. BioMOL can build a detailed model in 1-1,000 CPU sec using standard desktop hardware. The models solve and optimize using standard and widely available hardware and software and can be presented in the context of a user-friendly interface. We believe this is an engineering tool with great promise in its application to complex biological reaction networks. PMID:12634134

NASA's TReK Project: A Case Study in Using the Spiral Model of Software Development

NASA Technical Reports Server (NTRS)

Hendrix, T. Dean; Schneider, Michelle P.

1998-01-01

Software development projects face numerous challenges that threaten their successful completion. Whether it is not enough money, too little time, or a case of "requirements creep" that has turned into a full sprint, projects must meet these challenges or face possible disastrous consequences. A robust, yet flexible process model can provide a mechanism through which software development teams can meet these challenges head on and win. This article describes how the spiral model has been successfully tailored to a specific project and relates some notable results to date.

Early Formulation Model-centric Engineering on Nasa's Europa Mission Concept Study

NASA Technical Reports Server (NTRS)

Bayer, Todd; Chung, Seung; Cole, Bjorn; Cooke, Brian; Dekens, Frank; Delp, Chris; Gontijo, I.; Lewis, Kari; Moshir, Mehrdad; Rasmussen, Robert;

Sharing Responsibility for College Success: A Model Partnership Moves Students to Diplomas and Degrees

ERIC Educational Resources Information Center

Vargas, Joel

2014-01-01

In order to prepare the large number of postsecondary-educated youth our economy demands, high schools and higher education must break through the boundaries that have traditionally separated them and assume joint responsibility for student success. This brief describes an unusual school district partnership with colleges that has achieved…

Information Brokers: Case Studies of Successful Ventures.

ERIC Educational Resources Information Center

Holland Johnson, Alice Jane

This guide is intended for librarians planning to start an information brokerage, whether as an entrepreneur or as a member of a document delivery group in a library. The guide identifies specific skills and relevant characteristics required to establish a successful information brokerage firm and describes a model to assist readers in the process…

Success: The Way There Is More Fun than the Stay There.

ERIC Educational Resources Information Center

Trinchese, Toni

1978-01-01

The author notes that early sex stereotyping often prevents women from forming the aspirations and assertion skills necessary for occupational success. She describes how she escaped this conditioning and advanced herself by goal-setting and the help of role models. Part of a theme issue on women and leadership. (SJL)

Goals, Success Factors, and Barriers for Simulation-Based Learning: A Qualitative Interview Study in Health Care

ERIC Educational Resources Information Center

Dieckmann, Peter; Friis, Susanne Molin; Lippert, Anne; Ostergaard, Doris

2012-01-01

Introduction: This study describes (a) process goals, (b) success factors, and (c) barriers for optimizing simulation-based learning environments within the simulation setting model developed by Dieckmann. Methods: Seven simulation educators of different experience levels were interviewed using the Critical Incident Technique. Results: (a) The…

[Success factors in public healthy eating campaigns: a case study].

PubMed

Aschemann-Witzel, J; Pérez-Cueto, F J A; Strand, M; Verbeke, W; Bech-Larsen, T

2012-01-01

Public campaigns and interventions are rarely fully evaluated regarding their effectiveness. The analysis of past, successful activities can contribute to the future development of public campaigns and interventions for healthier eating. The study of public campaigns and interventions for healthier eating aimed at identifying the underlying success factors and describing their relation. Interviews were conducted with representatives of 11 cases that had been identified as especially successful in an earlier research step. The interviews were analysed with regard to possible success factors and the latter used to develop a model of success factor interrelation. It was found that success of the cases was first, attributed to characteristics of the macro environment or to public private partnerships in the initiation of campaigns, second, to the engagement of social communities, elements of empowerment of the target group and the implementation of social marketing measures, and thirdly, in citizens adoption of the campaign and in accompanying structural changes. The model and identified success factors underline that success can stem from three crucial phases: the set up of a campaign, the conduction and finally, the interrelation with the citizen. The model can serve as a guide in the future development of campaigns.

A review of telemedicine business models.

PubMed

Chen, Shengnan; Cheng, Alice; Mehta, Khanjan

2013-04-01

Telemedicine has become an increasingly popular option for long-distance/virtual medical care and education, but many telemedicine ventures fail to grow beyond the initial pilot stage. Studying the business models of successful telemedicine ventures can help develop business strategies for upcoming ventures. This article describes business models of eight telemedicine ventures from different regions of the world using Osterwalder's "Business Model Canvas." The ventures are chosen on the basis of their apparent success and their diverse value chains. The business models are compared to draw inferences and lessons regarding their business strategy and contextual factors that influenced it. Key differences between telemedicine business practices in developing and developed countries are also discussed. The purpose of this article is to inform and inspire the business strategy of the next generation of telemedicine ventures to be economically sustainable and to successfully address local healthcare challenges.

Current status of one- and two-dimensional numerical models: Successes and limitations

NASA Technical Reports Server (NTRS)

Schwartz, R. J.; Gray, J. L.; Lundstrom, M. S.

1985-01-01

The capabilities of one and two-dimensional numerical solar cell modeling programs (SCAP1D and SCAP2D) are described. The occasions when a two-dimensional model is required are discussed. The application of the models to design, analysis, and prediction are presented along with a discussion of problem areas for solar cell modeling.

A Tale of 2 Units: Lessons in Changing the Care Delivery Model.

PubMed

Wharton, Glenda; Berger, Jill; Williams, Tracy

2016-04-01

In response to patient care quality and satisfaction concerns, a hospital determined the need to change the care delivery model on some inpatient units. Two pilot units adopted 2 different models of care. The authors describe the change project, successful outcomes, and lessons learned.

Applicability of five models to simulate water infiltration into soil with added biochar

USDA-ARS?s Scientific Manuscript database

As a soil amendment, biochar can reduce soil bulk density, increase soil porosity, and alter soil aggregates and thus affect the infiltration. Researchers have proposed and revised several theoretical models to describe the process of soil infiltration. Although these models have been successfully u...

Crystal Model Kits for Use in the General Chemistry Laboratory.

ERIC Educational Resources Information Center

Kildahl, Nicholas J.; And Others

1986-01-01

Dynamic crystal model kits are described. Laboratory experiments in which students use these kits to build models have been extremely successful in providing them with an understanding of the three-dimensional structures of the common cubic unit cells as well as hexagonal and cubic closest-packing of spheres. (JN)

Piecewise multivariate modelling of sequential metabolic profiling data.

PubMed

Rantalainen, Mattias; Cloarec, Olivier; Ebbels, Timothy M D; Lundstedt, Torbjörn; Nicholson, Jeremy K; Holmes, Elaine; Trygg, Johan

2008-02-19

Modelling the time-related behaviour of biological systems is essential for understanding their dynamic responses to perturbations. In metabolic profiling studies, the sampling rate and number of sampling points are often restricted due to experimental and biological constraints. A supervised multivariate modelling approach with the objective to model the time-related variation in the data for short and sparsely sampled time-series is described. A set of piecewise Orthogonal Projections to Latent Structures (OPLS) models are estimated, describing changes between successive time points. The individual OPLS models are linear, but the piecewise combination of several models accommodates modelling and prediction of changes which are non-linear with respect to the time course. We demonstrate the method on both simulated and metabolic profiling data, illustrating how time related changes are successfully modelled and predicted. The proposed method is effective for modelling and prediction of short and multivariate time series data. A key advantage of the method is model transparency, allowing easy interpretation of time-related variation in the data. The method provides a competitive complement to commonly applied multivariate methods such as OPLS and Principal Component Analysis (PCA) for modelling and analysis of short time-series data.

Predictors and prevalence of successful aging among older Malaysians.

PubMed

Hamid, Tengku Aizan; Momtaz, Yadollah Abolfathi; Ibrahim, Rahimah

2012-01-01

Successful aging is an important and worldwide concept in gerontology. However, until recently, there has been very little known about successful aging in Malaysia. This study was designed to describe the prevalence and correlates of successful aging among older Malaysians. Data for this study were obtained from the national survey 'The Mental Health and Quality of Life of Older Malaysians'. For this study, successful aging was defined based on a multidimensional model, encompassing the avoidance of chronic disease and physical functioning difficulty, and maintenance of good psychocognitive functioning. The prevalence of successful aging among older Malaysians was calculated at 13.8% (CI: 12.6-15.1). Results of multiple logistic regression analysis showed that age, educational attainment, household income, and ethnicity were significantly associated with successful aging. Results of this study show that successful agers were more likely to be among the younger age, ethnic Chinese, and those with a higher education level and household income, after adjusting for all other variables in the model. Copyright © 2011 S. Karger AG, Basel.

Successful ageing by whose definition? Views of older, spiritually affiliated women.

PubMed

McCann Mortimer, Patricia; Ward, Lynn; Winefield, Helen

2008-12-01

Researchers have pointed to significant omissions in Rowe and Kahn's model of successful ageing and their lack of consultation with older people. This study examined late mid-life and older women's views of successful ageing. In-depth interviews were conducted with 14 women aged 60-89 years. Participants who identified themselves as spiritual and religious, or spiritual only and not religious, were recruited using the 'snowball technique'. Thematic analyses were conducted within an Interpretive Phenomenological Analysis framework. Participants described multiple dimensions of successful ageing with 15 subthemes grouped into three overarching categories of personal agency, social value and quality of life/quality of death. Participants' multidimensional views of successful ageing were broader than Rowe and Kahn's model and included the need to have a degree of autonomy over the place and manner of the last phase of life and final days (successful dying).

Setting Strategic Directions Using Critical Success Factors.

ERIC Educational Resources Information Center

Bourne, Bonnie; Gates, Larry; Cofer, James

2000-01-01

Describes implementation of a system-level planning model focused on institutional improvement and effectiveness at the University of Missouri. Details implementation of three phases of the strategic planning model (strategic analysis, strategic thinking/decision-making, and campus outreach/systems administration planning); identifies critical…

An "Independent" Path to College Success

ERIC Educational Resources Information Center

Danziger, Michael P.

2007-01-01

Less than 5 percent of the high school Class of 2003 in Hartford, Connecticut, is expected to graduate from a four-year college by 2008. In this article, the author describes a novel effort underway in Connecticut's capital, in which private schools are working to expand college access and success for urban students. Following the model used by…

Putting Partnerships on Paper: Creating Service Engagement Opportunities in Kinesiology and Recreation

ERIC Educational Resources Information Center

VanSickle, Jennifer L.; Schaumleffel, Nathan A.

2015-01-01

The purpose of this article is to describe a model for creating a successful service engagement partnership with a community organization that may lead to the development of a short- or long-term service engagement project or course. The article explains how to create a successful partnership, including how to identify and choose the right…

Dual degree partnership in nursing: an innovative undergraduate educational model.

PubMed

Bastable, Susan B; Markowitz, Marianne

2012-10-01

We report the success of a unique articulation Dual Degree Partnership in Nursing (DDPN) model. The process used to establish and implement this approach is described. Unlike typical 2+2 agreements between associate degree (AD) and bachelor degree (BS) nursing education programs, the DDPN is designed with a 1+2+1 sequence. Intended to attract high school students, this model provides the opportunity to earn two degrees (AD and BS) while experiencing a 4-year campus living and learning environment. This configuration was accomplished without compromising the integrity of either of the established programs. After collecting data over the past 6 years, this model demonstrates popularity with the traditional-aged student, as well as success from an academic perspective. Statistics on retention, graduation, and NCLEX® pass rates indicate the feasibility and success of the model. Based on the findings, the potential for replication is promising for other colleges interested in a similar collaboration. Copyright 2012, SLACK Incorporated.

Video Self-Modeling and Improving Oral Reading Fluency

ERIC Educational Resources Information Center

Chandler, Wanda Gail

2012-01-01

Self-modeling can take different forms but is described as a process where one observes one's own successful behavior and learns from it without dependence on any particular medium. In this study, two separate experiments were conducted to evaluate a video self-modeling (VSM) feedforward intervention. VSM feedforward (independent variable, IV),…

Modelling sociocognitive aspects of students' learning

NASA Astrophysics Data System (ADS)

Koponen, I. T.; Kokkonen, T.; Nousiainen, M.

2017-03-01

We present a computational model of sociocognitive aspects of learning. The model takes into account a student's individual cognition and sociodynamics of learning. We describe cognitive aspects of learning as foraging for explanations in the epistemic landscape, the structure (set by instructional design) of which guides the cognitive development through success or failure in foraging. We describe sociodynamic aspects as an agent-based model, where agents (learners) compare and adjust their conceptions of their own proficiency (self-proficiency) and that of their peers (peer-proficiency) in using explanatory schemes of different levels. We apply the model here in a case involving a three-tiered system of explanatory schemes, which can serve as a generic description of some well-known cases studied in empirical research on learning. The cognitive dynamics lead to the formation of dynamically robust outcomes of learning, seen as a strong preference for a certain explanatory schemes. The effects of social learning, however, can account for half of one's success in adopting higher-level schemes and greater proficiency. The model also predicts a correlation of dynamically emergent interaction patterns between agents and the learning outcomes.

Workplace Lactation Programs in Small WIC Service Sites: A Potential Model.

PubMed

Angeletti, Michelle A; Llossas, Jose R

2018-03-01

The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) has an opportunity to protect, promote, and support breastfeeding by implementing and modeling workplace lactation programs in small WIC agencies that may have barriers regarding the lack of both human and financial resources. The goal of this article was to describe effective strategies for agency administrators in small WIC service sites so that they can reduce barriers, successfully implement workplace lactation policies and programs, and model successful strategies for other small employers. Copyright © 2017 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

Creating a library holding group: an approach to large system integration.

PubMed

Huffman, Isaac R; Martin, Heather J; Delawska-Elliott, Basia

2016-10-01

Faced with resource constraints, many hospital libraries have considered joint operations. This case study describes how Providence Health & Services created a single group to provide library services. Using a holding group model, staff worked to unify more than 6,100 nonlibrary subscriptions and 14 internal library sites. Our library services grew by unifying 2,138 nonlibrary subscriptions and 11 library sites and hiring more library staff. We expanded access to 26,018 more patrons. A model with built-in flexibility allowed successful library expansion. Although challenges remain, this success points to a viable model of unified operations.

An Analytic Model for the Success Rate of a Robotic Actuator System in Hitting Random Targets.

PubMed

Bradley, Stuart

2015-11-20

Autonomous robotic systems are increasingly being used in a wide range of applications such as precision agriculture, medicine, and the military. These systems have common features which often includes an action by an "actuator" interacting with a target. While simulations and measurements exist for the success rate of hitting targets by some systems, there is a dearth of analytic models which can give insight into, and guidance on optimization, of new robotic systems. The present paper develops a simple model for estimation of the success rate for hitting random targets from a moving platform. The model has two main dimensionless parameters: the ratio of actuator spacing to target diameter; and the ratio of platform distance moved (between actuator "firings") to the target diameter. It is found that regions of parameter space having specified high success are described by simple equations, providing guidance on design. The role of a "cost function" is introduced which, when minimized, provides optimization of design, operating, and risk mitigation costs.

Small Business Training Models for Community Growth.

ERIC Educational Resources Information Center

Jellison, Holly M., Ed.

Nine successful community college programs for small business management training are described in this report in terms of their college and economic context, purpose, offerings, delivery modes, operating and marketing strategies, community outreach, support services, faculty and staff, evaluation, and future directions. The model programs are…

REVIEWS OF TOPICAL PROBLEMS: Physics of pulsar magnetospheres

NASA Astrophysics Data System (ADS)

Beskin, Vasilii S.; Gurevich, Aleksandr V.; Istomin, Yakov N.

1986-10-01

A self-consistent model of the magnetosphere of a pulsar is constructed. This model is based on a successive solution of the equations describing global properties of the magnetosphere and on a comparison of the basic predictions of the developed theory and observational data.

Computational Design of DNA-Binding Proteins.

PubMed

Thyme, Summer; Song, Yifan

2016-01-01

Predicting the outcome of engineered and naturally occurring sequence perturbations to protein-DNA interfaces requires accurate computational modeling technologies. It has been well established that computational design to accommodate small numbers of DNA target site substitutions is possible. This chapter details the basic method of design used in the Rosetta macromolecular modeling program that has been successfully used to modulate the specificity of DNA-binding proteins. More recently, combining computational design and directed evolution has become a common approach for increasing the success rate of protein engineering projects. The power of such high-throughput screening depends on computational methods producing multiple potential solutions. Therefore, this chapter describes several protocols for increasing the diversity of designed output. Lastly, we describe an approach for building comparative models of protein-DNA complexes in order to utilize information from homologous sequences. These models can be used to explore how nature modulates specificity of protein-DNA interfaces and potentially can even be used as starting templates for further engineering.

Model of succession in degraded areas based on carabid beetles (Coleoptera, Carabidae).

PubMed

Schwerk, Axel; Szyszko, Jan

2011-01-01

Degraded areas constitute challenging tasks with respect to sustainable management of natural resources. Maintaining or even establishing certain successional stages seems to be particularly important. This paper presents a model of the succession in five different types of degraded areas in Poland based on changes in the carabid fauna. Mean Individual Biomass of Carabidae (MIB) was used as a numerical measure for the stage of succession. The run of succession differed clearly among the different types of degraded areas. Initial conditions (origin of soil and origin of vegetation) and landscape related aspects seem to be important with respect to these differences. As characteristic phases, a 'delay phase', an 'increase phase' and a 'stagnation phase' were identified. In general, the runs of succession could be described by four different parameters: (1) 'Initial degradation level', (2) 'delay', (3) 'increase rate' and (4) 'recovery level'. Applying the analytic solution of the logistic equation, characteristic values for the parameters were identified for each of the five area types. The model is of practical use, because it provides a possibility to compare the values of the parameters elaborated in different areas, to give hints for intervention and to provide prognoses about future succession in the areas. Furthermore, it is possible to transfer the model to other indicators of succession.

Broadening the Horizon in Physics and English: The Career Management Series.

ERIC Educational Resources Information Center

Von Thater, Rose

2000-01-01

Describes how the Career Management Series was conceived and developed at the Center for Particle Astrophysics at the University of California at Berkeley, demystifying the job search, differentiating between process and skills, and looking at both the academic and nonacademic track. Describes how this model was then successfully adapted to the…

Journalists in the Age of ICTs: Work Demands and Educational Needs

ERIC Educational Resources Information Center

Veglis, Andreas; Pomportsis, Andreas

2014-01-01

This paper discusses in detail the issue of journalists' usage of information and communication technologies (ICTs). More precisely, it proposes a model describing the information space available for journalists. It also describes thoroughly the necessary ICT skills that a journalist must possess to cope successfully with the work demands. A…

Listening within the Social Contexts of Tutoring: Essential Component of the Mentoring Relationship.

ERIC Educational Resources Information Center

Cobb, Jeanne B.

2000-01-01

Describes the nature of social interactions within the context of tutorial sessions and describes the role of listening within the mentoring relationship as seen in fourth-grade at-risk children in a culturally diverse elementary school. Concludes that highly successful tutors were skillful communicators who modeled effective listening skills,…

Economic Time Series Modeling to Determine the Feasibility of Incorporating Drinking Water Treatment in Water Quality Trading

EPA Science Inventory

The critical steps required to evaluating the feasiblity of establishing a water quality trading market in a testbed watershed is described. Focus is given toward describing the problem of thin markets as a specifi barrier to successful trading. Economic theory for considering an...

Energy: Economic activity and energy demand; link to energy flow. Example: France

NASA Astrophysics Data System (ADS)

1980-10-01

The data derived from the EXPLOR and EPOM, Energy Flow Optimization Model are described. The core of the EXPLOR model is a circular system of relations involving consumer's demand, producer's outputs, and market prices. The solution of this system of relations is obtained by successive iterations; the final output is a coherent system of economic accounts. The computer program for this transition is described. The work conducted by comparing different energy demand models is summarized. The procedure is illustrated by a numerical projection to 1980 and 1985 using the existing version of the EXPLOR France model.

On the successful use of a simplified model to simulate the succession of toxic cyanobacteria in a hypereutrophic reservoir with a highly fluctuating water level.

PubMed

Fadel, Ali; Lemaire, Bruno J; Vinçon-Leite, Brigitte; Atoui, Ali; Slim, Kamal; Tassin, Bruno

2017-09-01

Many freshwater bodies worldwide that suffer from harmful algal blooms would benefit for their management from a simple ecological model that requires few field data, e.g. for early warning systems. Beyond a certain degree, adding processes to ecological models can reduce model predictive capabilities. In this work, we assess whether a simple ecological model without nutrients is able to describe the succession of cyanobacterial blooms of different species in a hypereutrophic reservoir and help understand the factors that determine these blooms. In our study site, Karaoun Reservoir, Lebanon, cyanobacteria Aphanizomenon ovalisporum and Microcystis aeruginosa alternatively bloom. A simple configuration of the model DYRESM-CAEDYM was used; both cyanobacteria were simulated, with constant vertical migration velocity for A. ovalisporum, with vertical migration velocity dependent on light for M. aeruginosa and with growth limited by light and temperature and not by nutrients for both species. The model was calibrated on two successive years with contrasted bloom patterns and high variations in water level. It was able to reproduce the measurements; it showed a good performance for the water level (root-mean-square error (RMSE) lower than 1 m, annual variation of 25 m), water temperature profiles (RMSE of 0.22-1.41 °C, range 13-28 °C) and cyanobacteria biomass (RMSE of 1-57 μg Chl a L -1 , range 0-206 μg Chl a L -1 ). The model also helped understand the succession of blooms in both years. The model results suggest that the higher growth rate of M. aeruginosa during favourable temperature and light conditions allowed it to outgrow A. ovalisporum. Our results show that simple model configurations can be sufficient not only for theoretical works when few major processes can be identified but also for operational applications. This approach could be transposed on other hypereutrophic lakes and reservoirs to describe the competition between dominant phytoplankton species, contribute to early warning systems or be used for management scenarios.

Culture Matters in Successful Curriculum Change: An International Study of the Influence of National and Organizational Culture Tested With Multilevel Structural Equation Modeling.

PubMed

Jippes, Mariëlle; Driessen, Erik W; Broers, Nick J; Majoor, Gerard D; Gijselaers, Wim H; van der Vleuten, Cees P M

2015-07-01

National culture has been shown to play a role in curriculum change in medical schools, and business literature has described a similar influence of organizational culture on change processes in organizations. This study investigated the impact of both national and organizational culture on successful curriculum change in medical schools internationally. The authors tested a literature-based conceptual model using multilevel structural equation modeling. For the operationalization of national and organizational culture, the authors used Hofstede's dimensions of culture and Quinn and Spreitzer's competing values framework, respectively. To operationalize successful curriculum change, the authors used two derivates: medical schools' organizational readiness for curriculum change developed by Jippes and colleagues, and change-related behavior developed by Herscovitch and Meyer. The authors administered a questionnaire in 2012 measuring the described operationalizations to medical schools in the process of changing their curriculum. Nine hundred ninety-one of 1,073 invited staff members from 131 of 345 medical schools in 56 of 80 countries completed the questionnaire. An initial poor fit of the model improved to a reasonable fit by two suggested modifications which seemed theoretically plausible. In sum, characteristics of national culture and organizational culture, such as a certain level of risk taking, flexible policies and procedures, and strong leadership, affected successful curriculum change. National and organizational culture influence readiness for change in medical schools. Therefore, medical schools considering curriculum reform should anticipate the potential impact of national and organizational culture.

Modeling the Car Crash Crisis Management System Using HiLA

NASA Astrophysics Data System (ADS)

Hölzl, Matthias; Knapp, Alexander; Zhang, Gefei

An aspect-oriented modeling approach to the Car Crash Crisis Management System (CCCMS) using the High-Level Aspect (HiLA) language is described. HiLA is a language for expressing aspects for UML static structures and UML state machines. In particular, HiLA supports both a static graph transformational and a dynamic approach of applying aspects. Furthermore, it facilitates methodologically turning use case descriptions into state machines: for each main success scenario, a base state machine is developed; all extensions to this main success scenario are covered by aspects. Overall, the static structure of the CCCMS is modeled in 43 classes, the main success scenarios in 13 base machines, the use case extensions in 47 static and 31 dynamic aspects, most of which are instantiations of simple aspect templates.

Open Source Molecular Modeling

PubMed Central

Pirhadi, Somayeh; Sunseri, Jocelyn; Koes, David Ryan

2016-01-01

The success of molecular modeling and computational chemistry efforts are, by definition, dependent on quality software applications. Open source software development provides many advantages to users of modeling applications, not the least of which is that the software is free and completely extendable. In this review we categorize, enumerate, and describe available open source software packages for molecular modeling and computational chemistry. PMID:27631126

Optimising the combination dosing strategy of abemaciclib and vemurafenib in BRAF-mutated melanoma xenograft tumours.

PubMed

Tate, Sonya C; Burke, Teresa F; Hartman, Daisy; Kulanthaivel, Palaniappan; Beckmann, Richard P; Cronier, Damien M

2016-03-15

Resistance to BRAF inhibition is a major cause of treatment failure for BRAF-mutated metastatic melanoma patients. Abemaciclib, a cyclin-dependent kinase 4 and 6 inhibitor, overcomes this resistance in xenograft tumours and offers a promising drug combination. The present work aims to characterise the quantitative pharmacology of the abemaciclib/vemurafenib combination using a semimechanistic pharmacokinetic/pharmacodynamic modelling approach and to identify an optimum dosing regimen for potential clinical evaluation. A PK/biomarker model was developed to connect abemaciclib/vemurafenib concentrations to changes in MAPK and cell cycle pathway biomarkers in A375 BRAF-mutated melanoma xenografts. Resultant tumour growth inhibition was described by relating (i) MAPK pathway inhibition to apoptosis, (ii) mitotic cell density to tumour growth and, under resistant conditions, (iii) retinoblastoma protein inhibition to cell survival. The model successfully described vemurafenib/abemaciclib-mediated changes in MAPK pathway and cell cycle biomarkers. Initial tumour shrinkage by vemurafenib, acquisition of resistance and subsequent abemaciclib-mediated efficacy were successfully captured and externally validated. Model simulations illustrate the benefit of intermittent vemurafenib therapy over continuous treatment, and indicate that continuous abemaciclib in combination with intermittent vemurafenib offers the potential for considerable tumour regression. The quantitative pharmacology of the abemaciclib/vemurafenib combination was successfully characterised and an optimised, clinically-relevant dosing strategy was identified.

Detailed Primitive-Based 3d Modeling of Architectural Elements

NASA Astrophysics Data System (ADS)

Remondino, F.; Lo Buglio, D.; Nony, N.; De Luca, L.

2012-07-01

The article describes a pipeline, based on image-data, for the 3D reconstruction of building façades or architectural elements and the successive modeling using geometric primitives. The approach overcome some existing problems in modeling architectural elements and deliver efficient-in-size reality-based textured 3D models useful for metric applications. For the 3D reconstruction, an opensource pipeline developed within the TAPENADE project is employed. In the successive modeling steps, the user manually selects an area containing an architectural element (capital, column, bas-relief, window tympanum, etc.) and then the procedure fits geometric primitives and computes disparity and displacement maps in order to tie visual and geometric information together in a light but detailed 3D model. Examples are reported and commented.

A Three Dimension Model to Demonstrate Head and Tail Fold Formation in Mammalian Embryos

ERIC Educational Resources Information Center

Bressler, Robert S.

1977-01-01

Many students have difficulty visualizing the delineation of the embryonic body from the flat germ disc. An easily-constructed model is described that has been used successfully to convey the dynamics of embryological events at Mount Sinai School of Medicine. (LBH)

Ecological Development through Service-Learning

ERIC Educational Resources Information Center

Baker, Daniel

2006-01-01

This article describes a successful model used in international service-learning projects that integrates economic development and ecological improvement. The principles of the model are discussed, including commitments to maintain partnerships over time, emphasize the transfer of knowledge from one generation of students to the next, start small,…

Abrupt Transitions for Youths Leaving School: Models of Interagency Cooperation.

ERIC Educational Resources Information Center

Karcz, Stanley A.; And Others

1985-01-01

Three programs that have been successful in facilitating the reenrollment of students from exiting juvenile detention facilities are described: the Lake County, IL, Youth Advocate Liaison Program; the Lake County, Florida, Multiagency/Special Education Program; and the Rock Island, Illinois, Coalition High School Model. (CL)

PACES: A Model of Student Well-Being

ERIC Educational Resources Information Center

Nelson, Mark D.; Tarabochia, Dawn W.; Koltz, Rebecca L.

2015-01-01

School counselors design, deliver, and evaluate comprehensive, developmental school counseling programs that are focused on enhancing student development and success. A model of student well-being, known as PACES, is defined and described that consists of five distinct and interactive domains: physical, affective, cognitive, economic, and social.…

Soil Systems for Upscaling Saturated Hydraulic Conductivity (Ksat) for Hydrological Modeling in the Critical Zone

USDA-ARS?s Scientific Manuscript database

Successful hydrological model predictions depend on appropriate framing of scale and the spatial-temporal accuracy of input parameters describing soil hydraulic properties. Saturated soil hydraulic conductivity (Ksat) is one of the most important properties influencing water movement through soil un...

Lessons from a Teacher Residency

ERIC Educational Resources Information Center

Goodwin, A. Lin; Roegman, Rachel; Reagan, Emilie Mitescu

2018-01-01

Teacher residencies, based on the medical school training model, are emerging as an innovative model of educator preparation. The authors describe one such program in New York City, the Teaching Residents at Teachers College (TR@TC). They say the program has been successful in recruiting nontraditional candidates (including minorities) into…

Application of natural analog studies to exploration for ore deposits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gustafson, D.L.

1995-09-01

Natural analogs are viewed as similarities in nature and are routinely utilized by exploration geologists in their search for economic mineral deposits. Ore deposit modeling is undertaken by geologists to direct their exploration activities toward favorable geologic environments and, therefore, successful programs. Two types of modeling are presented: (i) empirical model development based on the study of known ore deposit characteristics, and (ii) concept model development based on theoretical considerations and field observations that suggest a new deposit type, not known to exist in nature, may exist and justifies an exploration program. Key elements that are important in empirical modelmore » development are described, and examples of successful applications of these natural analogs to exploration are presented. A classical example of successful concept model development, the discovery of the McLaughlin gold mine in California, is presented. The utilization of natural analogs is an important facet of mineral exploration. Natural analogs guide explorationists in their search for new discoveries, increase the probability of success, and may decrease overall exploration expenditure.« less

The von Neumann model of measurement in quantum mechanics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mello, Pier A.

2014-01-08

We describe how to obtain information on a quantum-mechanical system by coupling it to a probe and detecting some property of the latter, using a model introduced by von Neumann, which describes the interaction of the system proper with the probe in a dynamical way. We first discuss single measurements, where the system proper is coupled to one probe with arbitrary coupling strength. The goal is to obtain information on the system detecting the probe position. We find the reduced density operator of the system, and show how Lüders rule emerges as the limiting case of strong coupling. The vonmore » Neumann model is then generalized to two probes that interact successively with the system proper. Now we find information on the system by detecting the position-position and momentum-position correlations of the two probes. The so-called 'Wigner's formula' emerges in the strong-coupling limit, while 'Kirkwood's quasi-probability distribution' is found as the weak-coupling limit of the above formalism. We show that successive measurements can be used to develop a state-reconstruction scheme. Finally, we find a generalized transform of the state and the observables based on the notion of successive measurements.« less

Critical Success Factor for Implementing Vocational Blended Learning

NASA Astrophysics Data System (ADS)

Dewi, K. C.; Ciptayani, P. I.; Surjono, H. D.; Priyanto

2018-01-01

Blended learning provides many benefits to the flexibility of time, place and situation constraints. The research’s objectives was describing the factors that determine the successful implementation of blended learning in vocational higher education. The research used a qualitative approach, data collected through observations and interviews by questionnare based on the CSFs indicators refers to TAM and Kliger. Data analysis was inductive method. The result provided an illustration that the success of vocational blended learning implementation was largely determined by the selection of instructional models that are inline with learning achievement target. The effectiveness of blended learning required the existence of policy support, readiness of IT infrastructure. Changing lecturer’s culture by utilizing ICT can also encourage the accelerated process of successful implementation. It can concluded that determinant factor of successful implementation of blended learning in vocational education is determined by teacher’s ability in mastering the pedagogical knowledge of designing instructional models.

The rabbit blood-shunt model for the study of acute and late sequelae of subarachnoid hemorrhage: technical aspects.

PubMed

Andereggen, Lukas; Neuschmelting, Volker; von Gunten, Michael; Widmer, Hans Rudolf; Takala, Jukka; Jakob, Stephan M; Fandino, Javier; Marbacher, Serge

2014-10-02

Early brain injury and delayed cerebral vasospasm both contribute to unfavorable outcomes after subarachnoid hemorrhage (SAH). Reproducible and controllable animal models that simulate both conditions are presently uncommon. Therefore, new models are needed in order to mimic human pathophysiological conditions resulting from SAH. This report describes the technical nuances of a rabbit blood-shunt SAH model that enables control of intracerebral pressure (ICP). An extracorporeal shunt is placed between the arterial system and the subarachnoid space, which enables examiner-independent SAH in a closed cranium. Step-by-step procedural instructions and necessary equipment are described, as well as technical considerations to produce the model with minimal mortality and morbidity. Important details required for successful surgical creation of this robust, simple and consistent ICP-controlled SAH rabbit model are described.

How to hit HIV where it hurts

NASA Astrophysics Data System (ADS)

Chakraborty, Arup

No medical procedure has saved more lives than vaccination. But, today, some pathogens have evolved which have defied successful vaccination using the empirical paradigms pioneered by Pasteur and Jenner. One characteristic of many pathogens for which successful vaccines do not exist is that they present themselves in various guises. HIV is an extreme example because of its high mutability. This highly mutable virus can evade natural or vaccine induced immune responses, often by mutating at multiple sites linked by compensatory interactions. I will describe first how by bringing to bear ideas from statistical physics (e.g., maximum entropy models, Hopfield models, Feynman variational theory) together with in vitro experiments and clinical data, the fitness landscape of HIV is beginning to be defined with explicit account for collective mutational pathways. I will describe how this knowledge can be harnessed for vaccine design. Finally, I will describe how ideas at the intersection of evolutionary biology, immunology, and statistical physics can help guide the design of strategies that may be able to induce broadly neutralizing antibodies.

Report of the LSPI/NASA Workshop on Lunar Base Methodology Development

NASA Technical Reports Server (NTRS)

Nozette, Stewart; Roberts, Barney

1985-01-01

Groundwork was laid for computer models which will assist in the design of a manned lunar base. The models, herein described, will provide the following functions for the successful conclusion of that task: strategic planning; sensitivity analyses; impact analyses; and documentation. Topics addressed include: upper level model description; interrelationship matrix; user community; model features; model descriptions; system implementation; model management; and plans for future action.

Using the Communication in Science Inquiry Project Professional Development Model to Facilitate Learning Middle School Genetics Concepts

ERIC Educational Resources Information Center

Baker, Dale R.; Lewis, Elizabeth B.; Uysal, Sibel; Purzer, Senay; Lang, Michael; Baker, Perry

2011-01-01

This study describes the effect of embedding content in the Communication in Inquiry Science Project professional development model for science and language arts teachers. The model uses four components of successful professional development (content focus, active learning, extended duration, participation by teams of teachers from the same school…

SPATS: a model for projecting softwood timber inventories in the Southern United States.

Treesearch

David J. Brooks

1987-01-01

The yield-table projection method for modeling the development of regional timber inventories is outlined, and its application to softwood timber types in the Southern United States is described. Problems of simulating forest management practices and natural succession are discussed. A computer model that projects softwood timber inventories using yield-table...

Schools-within-a-School: The Kapa'a Elementary School Model.

ERIC Educational Resources Information Center

Piper, Paul S.

1994-01-01

This document describes the successful schools-within-a-school (SWS) program implemented at Kapa'a Elementary School in Hawaii. The SWS model addresses the issue of school size and its ramifications. In 1989, the school sought the help of a leading educational researcher, Dr. Mary Anne Raywid, to develop a change model that gave the teachers…

Teacher Adoption of Moodle LMS: A K-12 Diffusion Study

ERIC Educational Resources Information Center

Gagnon, Daniel A.

2012-01-01

This paper describes the diffusion of Moodle within Cherokee County Schools. The diffusion is evaluated using the Bass Model and the RIPPLES model in order to evaluate relative success or failure. The Bass Model of Diffusion was calculated utilizing forecasting by analogy in order to analyze the adoption rates in a county high school. The adoption…

Harnessing Agency: Towards a Learning Model for Undergraduate Students

ERIC Educational Resources Information Center

Pym, June; Kapp, Rochelle

2013-01-01

This article describes a successful academic development programme in a Commerce faculty at a relatively elite, historically white university in South Africa. The writers argue that the programme has managed to achieve good results in recent years by moving away from deficit models of academic development for students from disadvantaged…

The Mathematical Contest in Modeling: Success at a Small Regional University.

ERIC Educational Resources Information Center

Parker, Mark; Zullo, Holly; Preyer, Norris

1999-01-01

Describes the Mathematical Contest in Modeling (MCM), a contest in which teams of three undergraduate students compete with other undergraduate teams from schools all over the world. Implements MCM at Eastern Oregon University and indicates that the MCM program promotes teamwork and generates enthusiasm in students. (Author/ASK)

Prediction models for successful external cephalic version: a systematic review.

PubMed

Velzel, Joost; de Hundt, Marcella; Mulder, Frederique M; Molkenboer, Jan F M; Van der Post, Joris A M; Mol, Ben W; Kok, Marjolein

2015-12-01

To provide an overview of existing prediction models for successful ECV, and to assess their quality, development and performance. We searched MEDLINE, EMBASE and the Cochrane Library to identify all articles reporting on prediction models for successful ECV published from inception to January 2015. We extracted information on study design, sample size, model-building strategies and validation. We evaluated the phases of model development and summarized their performance in terms of discrimination, calibration and clinical usefulness. We collected different predictor variables together with their defined significance, in order to identify important predictor variables for successful ECV. We identified eight articles reporting on seven prediction models. All models were subjected to internal validation. Only one model was also validated in an external cohort. Two prediction models had a low overall risk of bias, of which only one showed promising predictive performance at internal validation. This model also completed the phase of external validation. For none of the models their impact on clinical practice was evaluated. The most important predictor variables for successful ECV described in the selected articles were parity, placental location, breech engagement and the fetal head being palpable. One model was assessed using discrimination and calibration using internal (AUC 0.71) and external validation (AUC 0.64), while two other models were assessed with discrimination and calibration, respectively. We found one prediction model for breech presentation that was validated in an external cohort and had acceptable predictive performance. This model should be used to council women considering ECV. Copyright © 2015. Published by Elsevier Ireland Ltd.

Advancing Minorities and Women to the PhD in Physics and Astronomy

NASA Astrophysics Data System (ADS)

Stassun, Keivan

2017-01-01

We briefly review the current status of underrepresented minorities in physics and astronomy: The underrepresentation of Black-, Hispanic-, and Native-Americans is an order of magnitude problem. We then describe the Fisk-Vanderbilt Masters-to-PhD Bridge program as a successful model for addressing this problem. Since 2004 the program has admitted 110 students, 90% of them underrepresented minorities (50% female), with a retention rate of 90%. The program has become the top producer of African American master's degrees in physics, and is now one of the top producers of minority PhDs in astronomy, materials science, and physics. We summarize the main features of the program including its core strategies: (1) replacing the GRE in admissions with indicators that are better predictive of long-term success, (2) partnering with a minority-serving institution for student training through collaborative research, and (3) using the master's degree as a deliberate stepping stone to the PhD. We show how misuse of the GRE in graduate admissions may by itself in large part explain the ongoing underrepresentation of minorities in PhD programs, and we describe our alternate methods to identify talented individuals most likely to succeed. We describe our mentoring model and toolkit which may be utilized to enhance the success of all PhD students.

What Is Career Success for Academic Hospitalists? A Qualitative Analysis of Early-Career Faculty Perspectives.

PubMed

Cumbler, Ethan; Yirdaw, Essey; Kneeland, Patrick; Pierce, Read; Rendon, Patrick; Herzke, Carrie; Jones, Christine D

2018-06-01

Understanding the concept of career success is critical for hospital medicine groups seeking to create sustainably rewarding faculty positions. Conceptual models of career success describe both extrinsic (compensation and advancement) and intrinsic (career satisfaction and job satisfaction) domains. How hospitalists define career success for themselves is not well understood. In this study, we qualitatively explore perspectives on how early-career clinician-educators define career success. We developed a semistructured interview tool of open-ended questions validated by using cognitive interviewing. Transcribed interviews were conducted with 17 early-career academic hospitalists from 3 medical centers to thematic saturation. A mixed deductiveinductive, qualitative, analytic approach was used to code and map themes to the theoretical framework. The single most dominant theme participants described was "excitement about daily work," which mapped to the job satisfaction organizing theme. Participants frequently expressed the importance of "being respected and recognized" and "dissemination of work," which were within the career satisfaction organizing theme. The extrinsic organizing themes of advancement and compensation were described as less important contributors to an individual's sense of career success. Ambivalence toward the "academic value of clinical work," "scholarship," and especially "promotion" represented unexpected themes. The future of academic hospital medicine is predicated upon faculty finding career success. Clinician-educator hospitalists view some traditional markers of career advancement as relevant to success. However, early-career faculty question the importance of some traditional external markers to their personal definitions of success. This work suggests that the selfconcept of career success is complex and may not be captured by traditional academic metrics and milestones. © 2018 Society of Hospital Medicine

A Method for Calculating the Probability of Successfully Completing a Rocket Propulsion Ground Test

NASA Technical Reports Server (NTRS)

Messer, Bradley

2007-01-01

Propulsion ground test facilities face the daily challenge of scheduling multiple customers into limited facility space and successfully completing their propulsion test projects. Over the last decade NASA s propulsion test facilities have performed hundreds of tests, collected thousands of seconds of test data, and exceeded the capabilities of numerous test facility and test article components. A logistic regression mathematical modeling technique has been developed to predict the probability of successfully completing a rocket propulsion test. A logistic regression model is a mathematical modeling approach that can be used to describe the relationship of several independent predictor variables X(sub 1), X(sub 2),.., X(sub k) to a binary or dichotomous dependent variable Y, where Y can only be one of two possible outcomes, in this case Success or Failure of accomplishing a full duration test. The use of logistic regression modeling is not new; however, modeling propulsion ground test facilities using logistic regression is both a new and unique application of the statistical technique. Results from this type of model provide project managers with insight and confidence into the effectiveness of rocket propulsion ground testing.

Development of Novel Repellents Using Structure - Activity Modeling of Compounds in the USDA Archival Database

DTIC Science & Technology

2011-01-01

used in efforts to develop QSAR models. Measurement of Repellent Efficacy Screening for Repellency of Compounds with Unknown Toxicology In screening...CPT) were used to develop Quantitative Structure Activity Relationship ( QSAR ) models to predict repellency. Successful prediction of novel...acylpiperidine QSAR models employed 4 descriptors to describe the relationship between structure and repellent duration. The ANN model of the carboxamides did not

School Improvement Goal Setting: A Collaborative Model.

ERIC Educational Resources Information Center

Snyder, Karolyn J.; And Others

1983-01-01

Describes the successful use of the Delphi Dialog Technique (a goal-setting process) at East High School, Anchorage, Alaska, where it was used to obtain consensus among staff members about school-growth targets. (JW)

Learning Strategy Instruction: Exploring the Potential of Metacognition.

ERIC Educational Resources Information Center

Mayo, Karen E.

1993-01-01

Focuses on one cognitive strategy, metacognition, and describes the success of this strategy with students of varying ages and abilities. Provides a six-step model for implementing strategy instruction in the classroom. (RS)

A Successful Compensatory Education Model

ERIC Educational Resources Information Center

Stenner, A. Jackson; Mueller, Siegfried G.

1973-01-01

A major 6-year program in the Chicago schools has proven that the traditional gap between advantaged and disadvantaged students can be systematically and substantially eliminated. The Chicago Child Parent Center program is described. (Author)

Seeking Balance between Challenge and Success in an Age of Accountability: A First-Year Faculty Growth Model (FFGM)

ERIC Educational Resources Information Center

Tenuto, Penny L.; Gardiner, Mary E.

2013-01-01

Committing to a tenure-track role by novice university faculty has been described as a difficult marriage, and higher educational organizations referred to as greedy, pointing to the need for research on the transition experiences of faculty themselves. The first year for faculty on the tenure-track is critical for academic faculty success in a…

Increasing a Community College Governing Board's Engagement in Accountability for Student Success: What Are the Principal Influences?

ERIC Educational Resources Information Center

Welsh, Linda Susan Anderson

2010-01-01

Understanding the factors that influence a community college governing board to increase its engagement in accountability for student success was the purpose of this grounded theory case study. A further aim was to develop a model that described how these factors interact. A highly engaged community college governing board, as defined by a focus,…

The role of relationships in collaborative partnership success: Lessons from the Alaska Fourth R project.

PubMed

Crooks, Claire V; Exner-Cortens, Deinera; Siebold, Wendi; Moore, Kami; Grassgreen, Lori; Owen, Patricia; Rausch, Ann; Rosier, Mollie

2018-04-01

Collaborative partnerships are critical to achieving health equity. As such, it is important to understand what contributes to the success of such partnerships. This paper describes the Alaska Fourth R collaborative, a multisectoral group of agencies (including education, health and human services, the violence against women sector, the governor's council on domestic violence, and an external evaluator) that successfully planned, implemented and evaluated a multi-focus health education program statewide. The purpose of this paper was to explore the ways in which seven pre-identified factors contributed to the successful achievement of the collaborative's goals. This project was grounded in community-based research principles, and collectively, the group chose to use Roussos and Fawcett's (2000) seven-factor model as the basis for the project. Using this model as a guide, semi-structured interviews were conducted with five leaders from the key organizations in the collaborative. In interviews, stakeholders described how each of the seven factors functioned in the Alaska collaborative to contribute to project success, with a particular focus on the critical role of relationships. Three specific relationship facets emerged as cross-cutting themes: flexibility, transparency, and prioritization. In sum, taking the time to build deep and authentic relationships, and then developing a shared vision and mission within the context of relationships that are flexible, transparent and prioritized, provided a strong foundation for future success in this collaborative. Copyright © 2017 Elsevier Ltd. All rights reserved.

Model of succession in degraded areas based on carabid beetles (Coleoptera, Carabidae)

PubMed Central

Schwerk, Axel; Szyszko, Jan

2011-01-01

Abstract Degraded areas constitute challenging tasks with respect to sustainable management of natural resources. Maintaining or even establishing certain successional stages seems to be particularly important. This paper presents a model of the succession in five different types of degraded areas in Poland based on changes in the carabid fauna. Mean Individual Biomass of Carabidae (MIB) was used as a numerical measure for the stage of succession. The run of succession differed clearly among the different types of degraded areas. Initial conditions (origin of soil and origin of vegetation) and landscape related aspects seem to be important with respect to these differences. As characteristic phases, a ‘delay phase’, an ‘increase phase’ and a ‘stagnation phase’ were identified. In general, the runs of succession could be described by four different parameters: (1) ‘Initial degradation level’, (2) ‘delay’, (3) ‘increase rate’ and (4) ‘recovery level’. Applying the analytic solution of the logistic equation, characteristic values for the parameters were identified for each of the five area types. The model is of practical use, because it provides a possibility to compare the values of the parameters elaborated in different areas, to give hints for intervention and to provide prognoses about future succession in the areas. Furthermore, it is possible to transfer the model to other indicators of succession. PMID:21738419

Human factors systems approach to healthcare quality and patient safety

PubMed Central

Carayon, Pascale; Wetterneck, Tosha B.; Rivera-Rodriguez, A. Joy; Hundt, Ann Schoofs; Hoonakker, Peter; Holden, Richard; Gurses, Ayse P.

2013-01-01

Human factors systems approaches are critical for improving healthcare quality and patient safety. The SEIPS (Systems Engineering Initiative for Patient Safety) model of work system and patient safety is a human factors systems approach that has been successfully applied in healthcare research and practice. Several research and practical applications of the SEIPS model are described. Important implications of the SEIPS model for healthcare system and process redesign are highlighted. Principles for redesigning healthcare systems using the SEIPS model are described. Balancing the work system and encouraging the active and adaptive role of workers are key principles for improving healthcare quality and patient safety. PMID:23845724

Logic models as a tool for sexual violence prevention program development.

PubMed

Hawkins, Stephanie R; Clinton-Sherrod, A Monique; Irvin, Neil; Hart, Laurie; Russell, Sarah Jane

2009-01-01

Sexual violence is a growing public health problem, and there is an urgent need to develop sexual violence prevention programs. Logic models have emerged as a vital tool in program development. The Centers for Disease Control and Prevention funded an empowerment evaluation designed to work with programs focused on the prevention of first-time male perpetration of sexual violence, and it included as one of its goals, the development of program logic models. Two case studies are presented that describe how significant positive changes can be made to programs as a result of their developing logic models that accurately describe desired outcomes. The first case study describes how the logic model development process made an organization aware of the importance of a program's environmental context for program success; the second case study demonstrates how developing a program logic model can elucidate gaps in organizational programming and suggest ways to close those gaps.

Helping Students Make Decisions with the Help of Egan's Model.

ERIC Educational Resources Information Center

Stephens, Ginny Lee; Reynolds, JoLynne

1992-01-01

Discusses using Gerald Egan's model for creative decision making as a career counseling tool. Explains why to use this model and how it was adapted to meet career counseling issues. Describes its successful use in three case studies with a college sophomore in search of a major, a new graduate in search of a first job, and a homemaker. (Author/ABL)

Building Sustainable Professional Development Programs: Applying Strategies From Implementation Science to Translate Evidence Into Practice.

PubMed

Baldwin, Constance D; Chandran, Latha; Gusic, Maryellen E

2017-01-01

Multisite and national professional development (PD) programs for educators are challenging to establish. Use of implementation science (IS) frameworks designed to convert evidence-based intervention methods into effective health care practice may help PD developers translate proven educational methods and models into successful, well-run programs. Implementation of the national Educational Scholars Program (ESP) is used to illustrate the value of the IS model. Four adaptable elements of IS are described: (1) replication of an evidence-based model, (2) systematic stages of implementation, (3) management of implementation using three implementation drivers, and (4) demonstration of program success through measures of fidelity to proven models and sustainability. Implementation of the ESP was grounded on five established principles and methods for successful PD. The process was conducted in four IS stages over 10 years: Exploration, Installation, Initial Implementation, and Full Implementation. To ensure effective and efficient processes, attention to IS implementation drivers helped to manage organizational relationships, build competence in faculty and scholars, and address leadership challenges. We describe the ESP's fidelity to evidence-based structures and methods, and offer three examples of sustainability efforts that enabled achievement of targeted program outcomes, including academic productivity, strong networking, and career advancement of scholars. Application of IS frameworks to program implementation may help other PD programs to translate evidence-based methods into interventions with enhanced impact. A PD program can follow systematic developmental stages and be operationalized by practical implementation drivers, thereby creating successful and sustainable interventions that promote the academic vitality of health professions educators.

Successful Student Recruitment Using Direct Marketing and Information Technology.

ERIC Educational Resources Information Center

Merante, Joseph A.

1982-01-01

Educational marketing--which uses marketing methods unique to education institutions, including segmentation, direct mail, and information technology--is discussed. A model for student recruitment developed by the University of Pittsburgh is described. (Author/MLW)

Demonstrating the Relationship between School Nurse Workload and Student Outcomes

ERIC Educational Resources Information Center

Daughtry, Donna; Engelke, Martha Keehner

2018-01-01

This article describes how one very large, diverse school district developed a Student Acuity Tool for School Nurse Assignment and used a logic model to successfully advocate for additional school nurse positions. The logic model included three student outcomes that were evaluated: provide medications and procedures safely and accurately, increase…

A Model Job Rotation Plan: A 10-Year Follow-up.

ERIC Educational Resources Information Center

Robinson, Daniel C.; Delbridge-Parker, Linda

1991-01-01

Describes model job rotation plan in a college student affairs division in which a staff member (intern) rotates among departments as a staff development opportunity. A 10-year follow-up evaluation underscored the success of the program. Concludes job rotation is not just learning experience, but it is also sharing experience. (Author/ABL)

Land-use history and contemporary management inform an ecological reference model for longleaf pine woodland understory plant communities

Treesearch

Lars A. Brudvig; John L. Orrock; Ellen I. Damschen; Cathy D. Collins; Philip G. Hahn; W. Brett Mattingly; Joseph W. Veldman; Joan L. Walker

2014-01-01

Ecological restoration is frequently guided by reference conditions describing a successfully restored ecosystem; however, the causes and magnitude of ecosystem degradation vary, making simple knowledge of reference conditions insufficient for prioritizing and guiding restoration. Ecological reference models provide further guidance by quantifying reference conditions...

A Model for Wetland Hydrology: Description and Validation

Treesearch

R.S. Mansell; S.A. Bloom; Ge Sun

2000-01-01

WETLANDS, a multidimensional model describing water flow in variably saturated soil and evapotranspiration, was used to simulate successfully 3-years of local hydrology for a cypress pond located within a relatively flat Coastal Plain pine forest landscape. Assumptions included negligible net regional groundwater flow and radially symmetric local flow impinging on a...

Cue Salience and Infant Perseverative Reaching: Tests of the Dynamic Field Theory

ERIC Educational Resources Information Center

Clearfield, Melissa W.; Dineva, Evelina; Smith, Linda B.; Diedrich, Frederick J.; Thelen, Esther

2009-01-01

Skilled behavior requires a balance between previously successful behaviors and new behaviors appropriate to the present context. We describe a dynamic field model for understanding this balance in infant perseverative reaching. The model predictions are tested with regard to the interaction of two aspects of the typical perseverative reaching…

Cost Perception and the Expectancy-Value Model of Achievement Motivation.

ERIC Educational Resources Information Center

Anderson, Patricia N.

The expectancy-value model of achievement motivation, first described by J. Atkinson (1957) and refined by J. Eccles and her colleagues (1983, 1992, 1994) predicts achievement motivation based on expectancy for success and perceived task value. Cost has been explored very little. To explore the possibility that cost is different from expectancy…

Shared Mental Models in Support of Adaptive Instruction for Teams Using the GIFT Tutoring Architecture

ERIC Educational Resources Information Center

Fletcher, J. D.; Sottilare, Robert A.

2018-01-01

Teams and teamwork are ubiquitous in military and civilian organizations. Their importance to organizational success cannot be overstated. This article describes the relationship and effect of three concepts: Intelligent Tutoring Systems (ITSs), shared mental models, and teamwork. The nexus between these concepts is examined to determine its…

Let's Have a Coffee with the Standard Model of Particle Physics!

ERIC Educational Resources Information Center

Woithe, Julia; Wiener, Gerfried J.; Van der Veken, Frederik F.

2017-01-01

The Standard Model of particle physics is one of the most successful theories in physics and describes the fundamental interactions between elementary particles. It is encoded in a compact description, the so-called "Lagrangian," which even fits on t-shirts and coffee mugs. This mathematical formulation, however, is complex and only…

Teachers as Mentors: Models for Promoting Achievement with Disadvantaged and Underrepresented Students by Creating Community

ERIC Educational Resources Information Center

Ayalon, Aram

2011-01-01

The book describes two similar and successful models of youth mentoring used by two acclaimed urban high schools that have consistently achieved exceptional graduation rates. Providing a detailed description of their methods--based upon extensive observation, and interviews with teachers, students, administrators, and parents--this book makes a…

Curricular Learning Communities and Unprepared Students: How Faculty Can Provide a Foundation for Success

ERIC Educational Resources Information Center

Engstrom, Cathy McHugh

2008-01-01

The pedagogical assumptions and teaching practices of learning community models reflect exemplary conditions for learning, so using these models with unprepared students seems desirable and worthy of investigation. This chapter describes the key role of faculty in creating active, integrative learning experiences for students in basic skills…

Recreating Death's Acre in the School Yard: Using Pig Carcasses as Model Corpses to Teach Concepts of Forensic Entomology & Ecological Succession

ERIC Educational Resources Information Center

Schoenly, Kenneth G.; Haskell, Neal H.; Mills, David K.; Bieme-Ndi, Carine; Larsen, Kristie; Lee, Yer

2006-01-01

In this article, the authors describe how to construct a mock crime scene, acquire a pig carcass, sample its arthropod fauna, integrate photographic, climatic and arthropod successional data, and estimate the postmortem interval (PMI) from insect successional timetables. The experimental layout described in this article represents the untreated…

Optimising the combination dosing strategy of abemaciclib and vemurafenib in BRAF-mutated melanoma xenograft tumours

PubMed Central

Tate, Sonya C; Burke, Teresa F; Hartman, Daisy; Kulanthaivel, Palaniappan; Beckmann, Richard P; Cronier, Damien M

2016-01-01

Background: Resistance to BRAF inhibition is a major cause of treatment failure for BRAF-mutated metastatic melanoma patients. Abemaciclib, a cyclin-dependent kinase 4 and 6 inhibitor, overcomes this resistance in xenograft tumours and offers a promising drug combination. The present work aims to characterise the quantitative pharmacology of the abemaciclib/vemurafenib combination using a semimechanistic pharmacokinetic/pharmacodynamic modelling approach and to identify an optimum dosing regimen for potential clinical evaluation. Methods: A PK/biomarker model was developed to connect abemaciclib/vemurafenib concentrations to changes in MAPK and cell cycle pathway biomarkers in A375 BRAF-mutated melanoma xenografts. Resultant tumour growth inhibition was described by relating (i) MAPK pathway inhibition to apoptosis, (ii) mitotic cell density to tumour growth and, under resistant conditions, (iii) retinoblastoma protein inhibition to cell survival. Results: The model successfully described vemurafenib/abemaciclib-mediated changes in MAPK pathway and cell cycle biomarkers. Initial tumour shrinkage by vemurafenib, acquisition of resistance and subsequent abemaciclib-mediated efficacy were successfully captured and externally validated. Model simulations illustrate the benefit of intermittent vemurafenib therapy over continuous treatment, and indicate that continuous abemaciclib in combination with intermittent vemurafenib offers the potential for considerable tumour regression. Conclusions: The quantitative pharmacology of the abemaciclib/vemurafenib combination was successfully characterised and an optimised, clinically-relevant dosing strategy was identified. PMID:26978007

Strategy Guideline: Modeling Enclosure Design in Above-Grade Walls

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lstiburek, J.; Ueno, K.; Musunuru, S.

2016-02-24

The Strategy Guideline describes how to model and interpret results of models for above grade walls. The Measure Guideline analyzes the failure thresholds and criteria for above grade walls. A library of above-grade walls with historically successful performance was used to calibrate WUFI (Warme Und Feuchte Instationar) software models. The information is generalized for application to a broad population of houses within the limits of existing experience.

Analysis of steady-state salt-water upconing with application at Truro well field, Cape Cod, Massachusetts

USGS Publications Warehouse

Reilly, T.E.; Frimpter, M.H.; LeBlanc, D.R.; Goodman, A.S.

1987-01-01

Sharp interface methods have been used successfully to describe the physics of upconing. A finite-element model is developed to simulate a sharp interface for determination of the steady-state position of the interface and maximum permissible well discharges. The model developed is compared to previous published electric-analog model results of Bennett and others (1968). -from Authors

Nano Goes to School: A Teaching Model of the Atomic Force Microscope

ERIC Educational Resources Information Center

Planinsic, Gorazd; Kovac, Janez

2008-01-01

The paper describes a teaching model of the atomic force microscope (AFM), which proved to be successful in the role of an introduction to nanoscience in high school. The model can demonstrate the two modes of operation of the AFM (contact mode and oscillating mode) as well as some basic principles that limit the resolution of the method. It can…

A community college model to support nursing workforce diversity.

PubMed

Colville, Janet; Cottom, Sherry; Robinette, Teresa; Wald, Holly; Waters, Tomi

2015-02-01

Community College of Allegheny County (CCAC), Allegheny Campus, is situated on the North Side of Pittsburgh. The neighborhood is 60% African American. At the time of the Health Resources and Services Administration (HRSA) application, approximately one third of the students admitted to the program were African American, less than one third of whom successfully completed it. With the aid of HRSA funding, CCAC developed a model that significantly improved the success rate of disadvantaged students. Through the formation of a viable cohort, the nursing faculty nurtured success among the most at-risk students. The cohort was supported by a social worker, case managers who were nursing faculty, and tutors. Students formed study groups, actively participated in community activities, and developed leadership skills through participation in the Student Nurse Association of Pennsylvania. This article provides the rationale for the Registered Nurse (RN) Achievement Model, describes the components of RN Achievement, and discusses the outcomes of the initiative.

Objective analysis of observational data from the FGGE observing systems

NASA Technical Reports Server (NTRS)

Baker, W.; Edelmann, D.; Iredell, M.; Han, D.; Jakkempudi, S.

1981-01-01

An objective analysis procedure for updating the GLAS second and fourth order general atmospheric circulation models using observational data from the first GARP global experiment is described. The objective analysis procedure is based on a successive corrections method and the model is updated in a data assimilation cycle. Preparation of the observational data for analysis and the objective analysis scheme are described. The organization of the program and description of the required data sets are presented. The program logic and detailed descriptions of each subroutine are given.

User's guide for a large signal computer model of the helical traveling wave tube

NASA Technical Reports Server (NTRS)

Palmer, Raymond W.

1992-01-01

The use is described of a successful large-signal, two-dimensional (axisymmetric), deformable disk computer model of the helical traveling wave tube amplifier, an extensively revised and operationally simplified version. We also discuss program input and output and the auxiliary files necessary for operation. Included is a sample problem and its input data and output results. Interested parties may now obtain from the author the FORTRAN source code, auxiliary files, and sample input data on a standard floppy diskette, the contents of which are described herein.

Consistency, Verification, and Validation of Turbulence Models for Reynolds-Averaged Navier-Stokes Applications

NASA Technical Reports Server (NTRS)

Rumsey, Christopher L.

2009-01-01

In current practice, it is often difficult to draw firm conclusions about turbulence model accuracy when performing multi-code CFD studies ostensibly using the same model because of inconsistencies in model formulation or implementation in different codes. This paper describes an effort to improve the consistency, verification, and validation of turbulence models within the aerospace community through a website database of verification and validation cases. Some of the variants of two widely-used turbulence models are described, and two independent computer codes (one structured and one unstructured) are used in conjunction with two specific versions of these models to demonstrate consistency with grid refinement for several representative problems. Naming conventions, implementation consistency, and thorough grid resolution studies are key factors necessary for success.

Static and Dynamic Properties of Ferroelectric Thin Film Memories.

NASA Astrophysics Data System (ADS)

Duiker, Hendrik Matthew

Several properties of ferroelectric thin-film memories have been modeled. First, it has been observed experimentally that the bulk phase KNO_3 has a first-order phase transition, and that the transition temperature of KNO_3 thin-films increases as the thickness of the film is decreased. A Landau theory of first-order phase transitions in bulk systems has been generalized by adding surface terms to the free energy expansion to account for these transition properties. The model successfully describes the observed transition properties and predicts the existence of films in which the surfaces are ordered at temperatures higher than the bulk transition temperature. Second, the Avrami model of polarization-reversal kinetics has been modified to describe the following cases: ferroelectrics composed of a large number of small grains; ferroelectric thin-films in which nucleation occurs at the surfaces, not in the bulk; ferroelectrics in which long-range dipolar interactions significantly affect the nucleation rate; and non-square wave switching pulses. The models were verified by applying them to the results of two-dimensional Ising model simulations. It was shown that the models allow the possibility of directly obtaining microscopic parameters, such as the nucleation rate and domain wall velocity, from bulk measurements. Finally, a model describing the fatigue of ferroelectric memories has been developed. As a ferroelectric memory fatigues the spontaneous polarization per unit volume decreases, the switching time decreases, and eventually the memory "shorts out" and becomes conducting. The model assumes the following: during each polarization reversal the film undergoes, every unit cell in the film has a chance of "degrading" and thus losing an ion. Degraded cells no longer contribute to the polarization. The ions are allowed to diffuse to the surfaces of the film and form, with other ions, conducting dendrites which grow into the bulk of the film. Computer simulations performed on a two dimensional lattice with the above model successfully described the phenomena observed during the fatigue of PZT and other types of ferroelectric thin-film memories films.

Our personal space.

PubMed

Suthers, M

2000-10-01

Neuro Linguistic Programming (NLP) as a model of human behaviour is presented. Its basic tenets and the factors that give rise to the physiological and emotional response to an external event are described. A number of psychotherapeutic interventions are also described, along with the influence of NLP on sporting and academic success. Finally, an exploration of these ideas for the purpose of contributing to personal well-being is given.

Agent-Based Modeling in Systems Pharmacology.

PubMed

Cosgrove, J; Butler, J; Alden, K; Read, M; Kumar, V; Cucurull-Sanchez, L; Timmis, J; Coles, M

2015-11-01

Modeling and simulation (M&S) techniques provide a platform for knowledge integration and hypothesis testing to gain insights into biological systems that would not be possible a priori. Agent-based modeling (ABM) is an M&S technique that focuses on describing individual components rather than homogenous populations. This tutorial introduces ABM to systems pharmacologists, using relevant case studies to highlight how ABM-specific strengths have yielded success in the area of preclinical mechanistic modeling.

Two-Year Community: A 3+8 Model of Undergraduate Research for Community College STEM Majors

ERIC Educational Resources Information Center

Leggett-Robinson, Pamela M.; Villa, Brandi C.; Mooring, Suazette Reid

2015-01-01

This article describes the implementation of an innovative undergraduate research model for students attending a two-year institution. It gives students an opportunity to engage in undergraduate research at nearby four-year institutions, which provides a foundation that allows them to successfully make the transition to STEM programs at the…

Using Economic Impact Models as an Educational Tool in Community Economic Development Programming: Lessons from Pennsylvania and Wisconsin.

ERIC Educational Resources Information Center

Shields, Martin; Deller, Steven C.

2003-01-01

Outlines an educational process designed to help provide communities with economic, social, and political information using community economic impact modeling. Describes the process of community meetings using economic impact, community demographics, and fiscal impact modules and the local preconditions that help make the process successful. (SK)

A Wellness Approach to Career Counseling on the College Campus.

ERIC Educational Resources Information Center

Floerchinger, Debra S.; Young, Kelvin E.

"Wellness" is a widely used term to describe a participative process through which the individual becomes aware of and makes choices toward a more successful or healthy existence. Many colleges and universities have utilized wellness philosophies or models in a variety of areas. The wellness model serves as an outline for decision making in which…

The human element in technology transfer

NASA Technical Reports Server (NTRS)

Peake, H. J.

1978-01-01

A transfer model composed of three roles and their linkages was considered. This model and a growing body of experience was analyzed to provide guidance in the human elements of technology transfer. For example, criteria for selection of technology transfer agents was described, and some needed working climate factors were known. These concepts were successfully applied to transfer activities.

Partnership in Education: Lebanese Evolution of a Finnish Educational Model

ERIC Educational Resources Information Center

Ghosn, Irma-Kaarina

2004-01-01

In recent years, several anti-bullying programs have been developed, for instance in the UK, USA and New Zealand, but how successful these programs might be outside their own cultural context has not been investigated. This paper describes an action research project, the aim of which was to determine whether a pro-active model against intolerance…

Critical Components of a Summer Enrichment Program for Urban Low-Income Gifted Students

ERIC Educational Resources Information Center

Kaul, Corina R.; Johnsen, Susan K.; Witte, Mary M.; Saxon, Terrill F.

2015-01-01

Effective program models are needed for low-income youth. This article describes one successful summer enrichment program, University for Young People's Project Promise, and outlines three key components of a Partnership for Promoting Potential in Low-Income Gifted Students (Partnership Model), which is based on Lee, Olszewski-Kubilius, and…

SERA Scenarios of Early Market Fuel Cell Electric Vehicle Introductions: Modeling Framework, Regional Markets, and Station Clustering; NREL (National Renewable Energy Laboratory)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Melaina, M.

This presentation provides an overview of the Scenario Evaluation and Regionalization Analysis (SERA) model, describes the methodology for developing scenarios for hydrogen infrastructure development, outlines an example "Hydrogen Success" scenario, and discusses detailed scenario metrics for a particular case study region, the Northeast Corridor.

Ares I-X Thermal Model Correlation and Lessons Learned

NASA Technical Reports Server (NTRS)

Amundsen, Ruth M.

2010-01-01

The Ares I-X vehicle launched and flew successfully on October 28, 2009. This paper will describe the correlation of the vehicle thermal model to both ground testing and flight data. A main purpose of the vehicle model and ground testing was to ensure that the avionics within the vehicle were held within their thermal limits prior to launch and during flight. The correlation of the avionics box temperatures will be shown. Also, the lessons learned in the thermal discipline during the modeling, test, correlation to test, and flight of the Ares I-X flight test vehicle will be described. Lessons learned will cover thermal modeling, as well as management of the thermal discipline, thermal team, and thermal-related actions in design, testing, and flight.

Modeling of rheological characteristics of the fermented dairy products obtained by novel and traditional starter cultures.

PubMed

Vukić, Dajana V; Vukić, Vladimir R; Milanović, Spasenija D; Ilicić, Mirela D; Kanurić, Katarina G

2018-06-01

Tree different fermented dairy products obtained by conventional and non-conventional starter cultures were investigated in this paper. Textural and rheological characteristics as well as chemical composition during 21 days of storage were analysed and subsequent data processing was performed by principal component analysis. The analysis of samples` flow behaviour was focused on their time dependent properties. Parameters of Power law model described flow behaviour of samples depended on used starter culture and days of storage. The Power law model was applied successfully to describe the flow of the fermented milk, which had characteristics of shear thinning and non-Newtonian fluid behaviour.

End of Life in a Haitian American, Faith-Based Community: Caring for Family and Communal Unity.

PubMed

Ladd, Susan Charlotte; Gordon, Shirley C

This article presents two models resulting from a grounded theory study of the end-of-life decision-making process for Haitian Americans. Successful access to this vulnerable population was achieved through the faith-based community. The first model describes this faith-based community of Haitian Americans. The second model describes the process used by families in this community who must make end-of-life healthcare decisions. Implications for nursing practice and caring science include a need to improve the congruence between the nursing care provided at this vulnerable time and the cultural values of a population.

A model protocol for a diabetes and other noncommunicable disease field survey.

PubMed

Dowse, G K; Zimmet, P

1992-01-01

Field surveys of diabetes and other noncommunicable diseases and their risk factors are increasingly being performed in both developed and developing countries. Although individual priorities and circumstances will influence survey design, a model survey manual and protocol is described which might assist investigators in formulating plans and preparing manuals for their own surveys. The model presented has been successfully used in developing countries, for both rural and urban communities, over more than a decade. It describes examples of survey objectives, and gives specific details of survey procedures and measurement techniques which may be utilized. It contains sufficient flexibility to allow its adaptation to local circumstances.

Integrating empowerment evaluation and quality improvement to achieve healthcare improvement outcomes

PubMed Central

Wandersman, Abraham; Alia, Kassandra Ann; Cook, Brittany; Ramaswamy, Rohit

2015-01-01

While the body of evidence-based healthcare interventions grows, the ability of health systems to deliver these interventions effectively and efficiently lags behind. Quality improvement approaches, such as the model for improvement, have demonstrated some success in healthcare but their impact has been lessened by implementation challenges. To help address these challenges, we describe the empowerment evaluation approach that has been developed by programme evaluators and a method for its application (Getting To Outcomes (GTO)). We then describe how GTO can be used to implement healthcare interventions. An illustrative healthcare quality improvement example that compares the model for improvement and the GTO method for reducing hospital admissions through improved diabetes care is described. We conclude with suggestions for integrating GTO and the model for improvement. PMID:26178332

Kinetic Theory and Simulation of Single-Channel Water Transport

NASA Astrophysics Data System (ADS)

Tajkhorshid, Emad; Zhu, Fangqiang; Schulten, Klaus

Water translocation between various compartments of a system is a fundamental process in biology of all living cells and in a wide variety of technological problems. The process is of interest in different fields of physiology, physical chemistry, and physics, and many scientists have tried to describe the process through physical models. Owing to advances in computer simulation of molecular processes at an atomic level, water transport has been studied in a variety of molecular systems ranging from biological water channels to artificial nanotubes. While simulations have successfully described various kinetic aspects of water transport, offering a simple, unified model to describe trans-channel translocation of water turned out to be a nontrivial task.

Challenges in the development of chronic pulmonary hypertension models in large animals

PubMed Central

Rothman, Abraham; Wiencek, Robert G.; Davidson, Stephanie; Evans, William N.; Restrepo, Humberto; Sarukhanov, Valeri; Mann, David

2017-01-01

Pulmonary hypertension (PH) results in significant morbidity and mortality. Chronic PH animal models may advance the study of PH’s mechanisms, evolution, and therapy. In this report, we describe the challenges and successes in developing three models of chronic PH in large animals: two models (one canine and one swine) utilized repeated infusions of ceramic microspheres into the pulmonary vascular bed, and the third model employed a surgical aorto-pulmonary shunt. In the canine model, seven dogs underwent microsphere infusions that resulted in progressive elevation of pulmonary arterial pressure over a few months. In this model, pulmonary endoarterial tissue was obtained for histology. In the aorto-pulmonary shunt swine model, 17 pigs developed systemic level pulmonary pressures after 2–3 months. In this model, pulmonary endoarterial tissue was sequentially obtained to assess for changes in gene and microRNA expression. In the swine microsphere infusion model, three pigs developed only a modest chronic increase in pulmonary arterial pressure, despite repeated infusions of microspheres (up to 40 in one animal). The main purpose of this model was for vasodilator testing, which was performed successfully immediately after acute microsphere infusions. Chronic PH in large animal models can be successfully created; however, a model’s characteristics need to match the investigational goals. PMID:28680575

Mathematical modeling and analysis of heat pipe start-up from the frozen state

NASA Technical Reports Server (NTRS)

Jang, Jong Hoon; Faghri, Amir; Chang, Won Soon; Mahefkey, Edward T.

1989-01-01

The start-up process of a frozen heat pipe is described and a complete mathematical model for the start-up of the frozen heat pipe is developed based on the existing experimental data, which is simplified and solved numerically. The two-dimensional transient model for the wall and wick is coupled with the one-dimensional transient model for the vapor flow when vaporization and condensation occur at the interface. A parametric study is performed to examine the effect of the boundary specification at the surface of the outer wall on the successful start-up from the frozen state. For successful start-up, the boundary specification at the outer wall surface must melt the working substance in the condenser before dry-out takes place in the evaporator.

Mathematical modeling and analysis of heat pipe start-up from the frozen state

NASA Technical Reports Server (NTRS)

Jang, J. H.; Faghri, A.; Chang, W. S.; Mahefkey, E. T.

1990-01-01

The start-up process of a frozen heat pipe is described and a complete mathematical model for the start-up of the frozen heat pipe is developed based on the existing experimental data, which is simplified and solved numerically. The two-dimensional transient model for the wall and wick is coupled with the one-dimensional transient model for the vapor flow when vaporization and condensation occur at the interface. A parametric study is performed to examine the effect of the boundary specification at the surface of the outer wall on the successful start-up from the frozen state. For successful start-up, the boundary specification at the outer wall surface must melt the working substance in the condenser before dry-out takes place in the evaporator.

Model Guided Design and Development Process for an Electronic Health Record Training Program

PubMed Central

He, Ze; Marquard, Jenna; Henneman, Elizabeth

2016-01-01

Effective user training is important to ensure electronic health record (EHR) implementation success. Though many previous studies report best practice principles and success and failure stories, current EHR training is largely empirically-based and often lacks theoretical guidance. In addition, the process of training development is underemphasized and underreported. A white paper by the American Medical Informatics Association called for models of user training for clinical information system implementation; existing instructional development models from learning theory provide a basis to meet this call. We describe in this paper our experiences and lessons learned as we adapted several instructional development models to guide our development of EHR user training. Specifically, we focus on two key aspects of this training development: training content and training process. PMID:28269940

Predicting length of children's psychiatric hospitalizations: an "ecologic" approach.

PubMed

Mossman, D; Songer, D A; Baker, D G

1991-08-01

This article describes the development and validation of a simple and modestly successful model for predicting inpatient length of stay (LOS) at a state-funded facility providing acute to long term care for children and adolescents in Ohio. Six variables--diagnostic group, legal status at time of admission, attending physician, age, sex, and county of residence--explained 30% of the variation in log10LOS in the subgroup used to create the model, and 26% of log10LOS variation in the cross-validation subgroup. The model also identified LOS outliers with moderate accuracy (ROC area = .68-0.76). The authors attribute the model's success to inclusion of variables that are correlated to idiosyncratic "ecologic" factors as well as variables related to severity of illness. Future attempts to construct LOS models may adopt similar approaches.

Parameter sensitivity analysis for pesticide impacts on honeybee colonies

EPA Science Inventory

We employ Monte Carlo simulation and linear sensitivity analysis techniques to describe the dynamics of a bee exposure model, VarroaPop. Daily simulations are performed that simulate hive population trajectories, taking into account queen strength, foraging success, weather, colo...

Sobol’ sensitivity analysis for stressor impacts on honeybee colonies

EPA Science Inventory

We employ Monte Carlo simulation and nonlinear sensitivity analysis techniques to describe the dynamics of a bee exposure model, VarroaPop. Daily simulations are performed of hive population trajectories, taking into account queen strength, foraging success, mite impacts, weather...

Radiology Consultation in the Era of Precision Oncology: A Review of Consultation Models and Services in the Tertiary Setting.

PubMed

DiPiro, Pamela J; Krajewski, Katherine M; Giardino, Angela A; Braschi-Amirfarzan, Marta; Ramaiya, Nikhil H

2017-01-01

The purpose of the article is to describe the various radiology consultation models in the Era of Precision Medicine. Since the inception of our specialty, radiologists have served as consultants to physicians of various disciplines. A variety of radiology consultation services have been described in the literature, including clinical decision support, patient-centric, subspecialty interpretation, and/or some combination of these. In oncology care in particular, case complexity often merits open dialogue with clinical providers. To explore the utility and impact of radiology consultation services in the academic setting, this article will further describe existing consultation models and the circumstances that precipitated their development. The hybrid model successful at our tertiary cancer center is discussed. In addition, the contributions of a consultant radiologist in breast cancer care are reviewed as the archetype of radiology consultation services provided to oncology practitioners.

A review of active learning approaches to experimental design for uncovering biological networks

PubMed Central

2017-01-01

Various types of biological knowledge describe networks of interactions among elementary entities. For example, transcriptional regulatory networks consist of interactions among proteins and genes. Current knowledge about the exact structure of such networks is highly incomplete, and laboratory experiments that manipulate the entities involved are conducted to test hypotheses about these networks. In recent years, various automated approaches to experiment selection have been proposed. Many of these approaches can be characterized as active machine learning algorithms. Active learning is an iterative process in which a model is learned from data, hypotheses are generated from the model to propose informative experiments, and the experiments yield new data that is used to update the model. This review describes the various models, experiment selection strategies, validation techniques, and successful applications described in the literature; highlights common themes and notable distinctions among methods; and identifies likely directions of future research and open problems in the area. PMID:28570593

Making a Medical Home for IBD Patients.

PubMed

Kosinski, Lawrence R; Brill, Joel; Regueiro, Miguel

2017-05-01

The transformation from fee for service to fee for value requires structural changes to the way gastroenterologists manage patients with inflammatory bowel disease (IBD). A team-based approach using technology to engage patients is necessary for success. The Patient-Centered Medical Home (PCMH) represents a unique model that brings together these essential features. This paper describes how the PCMH model has been successfully applied to the management of patients with IBD. A review of the literature and three examples of IBD PCMH initiatives are presented in this document: they demonstrate how outcomes can be improved under the PCMH model. Population health and value-based payments will mold and shape how we can position our GI practices. The specialty medical home is an ideal way to begin this transition.

Components of nurse innovation: a model from acute care hospitals.

PubMed

Neidlinger, S H; Drews, N; Hukari, D; Bartleson, B J; Abbott, F K; Harper, R; Lyon, J

1992-12-01

Components that promote nurse innovation in acute care hospitals are explicated in the Acute Care Nursing Innovation Model. Grounded in nursing care delivery systems and excellent management-organizations perspectives, nurse executives and 30 nurse "intrapreneurs" from 10 innovative hospitals spanning the United States shared their experiences and insights through semistructured, tape-recorded telephone interviews. Guided by interpretive interactionist strategies, the essential components, characteristics, and interrelationships are conceptualized and described so that others may be successful in their innovative endeavors. Successful innovation is dependent on the fit between and among the components; the better the fit, the more likely the innovation will succeed.

Successful management of vaginismus: An eclectic approach

PubMed Central

Harish, Thippeswamy; Muliyala, KrishnaPrasad; Murthy, Pratima

2011-01-01

Vaginismus is defined as recurrent or persistent involuntary spasm of the musculature of the outer third of the vagina, which interferes with coitus and causes distress and interpersonal difficulty. In this report, we describe the successful treatment of vaginismus in a 25-year-old lady based on a model proposed by Keith Hawton. The eclectic approach involved education, graded insertion of fingers, Kegel's exercises and usage of local anesthesia with vaginal containment along with the prescription of Escitalopram. PMID:21772650

Successful management of vaginismus: An eclectic approach.

PubMed

Harish, Thippeswamy; Muliyala, Krishnaprasad; Murthy, Pratima

2011-04-01

Vaginismus is defined as recurrent or persistent involuntary spasm of the musculature of the outer third of the vagina, which interferes with coitus and causes distress and interpersonal difficulty. In this report, we describe the successful treatment of vaginismus in a 25-year-old lady based on a model proposed by Keith Hawton. The eclectic approach involved education, graded insertion of fingers, Kegel's exercises and usage of local anesthesia with vaginal containment along with the prescription of Escitalopram.

Career Mapping for Professional Development and Succession Planning.

PubMed

Webb, Tammy; Diamond-Wells, Tammy; Jeffs, Debra

Career mapping facilitates professional development of nurses by education specialists and nurse managers. On the basis of national Nursing Professional Development Scope and Standards, our education and professional development framework supports the organization's professional practice model and provides a foundation for the professional career map. This article describes development, implementation, and evaluation of the professional career map for nurses at a large children's hospital to support achievement of the nursing strategic goals for succession planning and professional development.

Use of a PhET Interactive Simulation in General Chemistry Laboratory: Models of the Hydrogen Atom

ERIC Educational Resources Information Center

Clark, Ted M.; Chamberlain, Julia M.

2014-01-01

An activity supporting the PhET interactive simulation, Models of the Hydrogen Atom, has been designed and used in the laboratory portion of a general chemistry course. This article describes the framework used to successfully accomplish implementation on a large scale. The activity guides students through a comparison and analysis of the six…

A model for evaluating academic research centers: Case study of the Asian/Pacific Islander Youth Violence Prevention Center.

PubMed

Nishimura, Stephanie T; Hishinuma, Earl S; Goebert, Deborah A; Onoye, Jane M M; Sugimoto-Matsuda, Jeanelle J

2018-02-01

To provide one model for evaluating academic research centers, given their vital role in addressing public health issues. A theoretical framework is described for a comprehensive evaluation plan for research centers. This framework is applied to one specific center by describing the center's Logic Model and Evaluation Plan, including a sample of the center's activities. Formative and summative evaluation information is summarized. In addition, a summary of outcomes is provided: improved practice and policy; reduction of risk factors and increase in protective factors; reduction of interpersonal youth violence in the community; and national prototype for prevention of interpersonal youth violence. Research centers are important mechanisms to advance science and improve people's quality of life. Because of their more infrastructure-intensive and comprehensive approach, they also require substantial resources for success, and thus, also require careful accountability. It is therefore important to comprehensively evaluate these centers. As provided herein, a more systematic and structured approach utilizing logic models, an evaluation plan, and successful processes can provide research centers with a functionally useful method in their evaluation. Copyright © 2017 Elsevier Ltd. All rights reserved.

A succession of theories: purging redundancy from disturbance theory.

PubMed

Pulsford, Stephanie A; Lindenmayer, David B; Driscoll, Don A

2016-02-01

The topics of succession and post-disturbance ecosystem recovery have a long and convoluted history. There is extensive redundancy within this body of theory, which has resulted in confusion, and the links among theories have not been adequately drawn. This review aims to distil the unique ideas from the array of theory related to ecosystem change in response to disturbance. This will help to reduce redundancy, and improve communication and understanding between researchers. We first outline the broad range of concepts that have developed over the past century to describe community change in response to disturbance. The body of work spans overlapping succession concepts presented by Clements in 1916, Egler in 1954, and Connell and Slatyer in 1977. Other theories describing community change include state and transition models, biological legacy theory, and the application of functional traits to predict responses to disturbance. Second, we identify areas of overlap of these theories, in addition to highlighting the conceptual and taxonomic limitations of each. In aligning each of these theories with one another, the limited scope and relative inflexibility of some theories becomes apparent, and redundancy becomes explicit. We identify a set of unique concepts to describe the range of mechanisms driving ecosystem responses to disturbance. We present a schematic model of our proposed synthesis which brings together the range of unique mechanisms that were identified in our review. The model describes five main mechanisms of transition away from a post-disturbance community: (i) pulse events with rapid state shifts; (ii) stochastic community drift; (iii) facilitation; (iv) competition; and (v) the influence of the initial composition of a post-disturbance community. In addition, stabilising processes such as biological legacies, inhibition or continuing disturbance may prevent a transition between community types. Integrating these six mechanisms with the functional trait approach is likely to improve the predictive capacity of disturbance theory. Finally, we complement our discussion of theory with a case study which emphasises that many post-disturbance theories apply simultaneously to the same ecosystem. Using the well-studied mountain ash (Eucalyptus regnans) forests of south-eastern Australia, we illustrate phenomena that align with six of the theories described in our model of rationalised disturbance theory. We encourage further work to improve our schematic model, increase coverage of disturbance-related theory, and to show how the model may link to, or integrate with, other domains of ecological theory. © 2014 Cambridge Philosophical Society.

Taking the mystery out of mathematical model applications to karst aquifers—A primer

USGS Publications Warehouse

Kuniansky, Eve L.

2014-01-01

Advances in mathematical model applications toward the understanding of the complex flow, characterization, and water-supply management issues for karst aquifers have occurred in recent years. Different types of mathematical models can be applied successfully if appropriate information is available and the problems are adequately identified. The mathematical approaches discussed in this paper are divided into three major categories: 1) distributed parameter models, 2) lumped parameter models, and 3) fitting models. The modeling approaches are described conceptually with examples (but without equations) to help non-mathematicians understand the applications.

Multiobjective optimization and multivariable control of the beer fermentation process with the use of evolutionary algorithms.

PubMed

Andrés-Toro, B; Girón-Sierra, J M; Fernández-Blanco, P; López-Orozco, J A; Besada-Portas, E

2004-04-01

This paper describes empirical research on the model, optimization and supervisory control of beer fermentation. Conditions in the laboratory were made as similar as possible to brewery industry conditions. Since mathematical models that consider realistic industrial conditions were not available, a new mathematical model design involving industrial conditions was first developed. Batch fermentations are multiobjective dynamic processes that must be guided along optimal paths to obtain good results. The paper describes a direct way to apply a Pareto set approach with multiobjective evolutionary algorithms (MOEAs). Successful finding of optimal ways to drive these processes were reported. Once obtained, the mathematical fermentation model was used to optimize the fermentation process by using an intelligent control based on certain rules.

Contextual Learning Issues.

ERIC Educational Resources Information Center

1999

This document contains four symposium papers on contextual learning issues. "Learning to Learn Strategies of Successful Real Estate Professionals: Implications for Learning in the Workplace" (Margot B. Weinstein) describes a multicase study in which a model called the Individual Learning System was used to identify the strategies and…

HPT: The Culture Factor.

ERIC Educational Resources Information Center

Addison, Roger M.; Wittkuhn, Klaus D.

2001-01-01

Discusses the challenges in managing performance across national cultures and within changing corporate cultures. Describes two human performance technology tools that can help performance consultants understand different cultures and provide the basis for successful management action: the culture audit and the systems model that can be adapted…

Instructional Variables that Make a Difference: Attention to Task and Beyond.

ERIC Educational Resources Information Center

Rieth, Herbert J.; And Others

1981-01-01

Three procedures for increasing the disabled students' academic learning time(ALT)by maximizing allocation time, engagement time, and success rate are discussed, and a direct instructional model for enhancing ALT in both regular and special education environments is described. (CL)

A new percolation model for composite solid electrolytes and dispersed ionic conductors

NASA Astrophysics Data System (ADS)

Risyad Hasyim, Muhammad; Lanagan, Michael T.

2018-02-01

Composite solid electrolytes (CSEs) including conductor/insulator composites known as dispersed ionic conductors (DICs) have motivated the development of novel percolation models that describe their conductivity. Despite the long history, existing models lack in one or more key areas: (1) rigorous foundation for their physical theory, (2) explanation for non-universal conductor-insulator transition, (3) classification of DICs, and (4) extension to frequency-domain. This work describes a frequency-domain effective medium approximation (EMA) of a bond percolation model for CSEs. The EMA is derived entirely from Maxwell’s equations and contains basic microstructure parameters. The model was applied successfully to several composite systems from literature. Simulations and fitting of literature data address these key areas and illustrate the interplay between space charge layer properties and bulk microstructure.

Successful Hybrid Approach to Visual and Video Observations of the 1999 Leonid Storm

NASA Technical Reports Server (NTRS)

Jenniskens, Peter; Crawford, Chris; Butow, Steve; DeVincenzi, Donald L. (Technical Monitor)

2000-01-01

A new hybrid technique of visual and video meteor observations is described. The method proved particularly effective for airborne observations of meteor shower activity. Results from the 1999 Leonid Multi-Instrument Aircraft Campaign are presented, and the profile shape of the 1999 Leonid storm is discussed in relation to meteor shower models. We find that the storm is best described with a Lorentz profile. Application to past meteor outbursts shows that the cui,rent multi-trailet model of a dust trail is slightly shifted and we crossed deeper into the 1899 epoch trallet than expected.

Efficacy of Multimedia Instruction and an Introduction to Digital Multimedia Technology

DTIC Science & Technology

1992-07-01

performed by Bandura , Ro3s and Ross (1961). They found that children exposed to an adult displaying aggression toward a Bobo doll later also performed...and enjoy successful task performance. 7 Modeling Bandura (1969) describes modeling as the ability of individuals to learn a behavior or attitude... Bandura argued that all learning involving direct reinforcement could also result from observation. A classic study of modeling is an experiment

Assessing Performance Tradeoffs in Undersea Distributed Sensor Networks

DTIC Science & Technology

2006-09-01

time. We refer to this process as track - before - detect (see [5] for a description), since the final determination of a target presence is not made until...expressions for probability of successful search and probability of false search for modeling the track - before - detect process. We then describe a numerical...random manner (randomly sampled from a uniform distribution). II. SENSOR NETWORK PERFORMANCE MODELS We model the process of track - before - detect by

Toward University Modeling Instruction—Biology: Adapting Curricular Frameworks from Physics to Biology

PubMed Central

Manthey, Seth; Brewe, Eric

2013-01-01

University Modeling Instruction (UMI) is an approach to curriculum and pedagogy that focuses instruction on engaging students in building, validating, and deploying scientific models. Modeling Instruction has been successfully implemented in both high school and university physics courses. Studies within the physics education research (PER) community have identified UMI's positive impacts on learning gains, equity, attitudinal shifts, and self-efficacy. While the success of this pedagogical approach has been recognized within the physics community, the use of models and modeling practices is still being developed for biology. Drawing from the existing research on UMI in physics, we describe the theoretical foundations of UMI and how UMI can be adapted to include an emphasis on models and modeling for undergraduate introductory biology courses. In particular, we discuss our ongoing work to develop a framework for the first semester of a two-semester introductory biology course sequence by identifying the essential basic models for an introductory biology course sequence. PMID:23737628

Toward university modeling instruction--biology: adapting curricular frameworks from physics to biology.

PubMed

Manthey, Seth; Brewe, Eric

2013-06-01

University Modeling Instruction (UMI) is an approach to curriculum and pedagogy that focuses instruction on engaging students in building, validating, and deploying scientific models. Modeling Instruction has been successfully implemented in both high school and university physics courses. Studies within the physics education research (PER) community have identified UMI's positive impacts on learning gains, equity, attitudinal shifts, and self-efficacy. While the success of this pedagogical approach has been recognized within the physics community, the use of models and modeling practices is still being developed for biology. Drawing from the existing research on UMI in physics, we describe the theoretical foundations of UMI and how UMI can be adapted to include an emphasis on models and modeling for undergraduate introductory biology courses. In particular, we discuss our ongoing work to develop a framework for the first semester of a two-semester introductory biology course sequence by identifying the essential basic models for an introductory biology course sequence.

Analysis of survival data from telemetry projects

USGS Publications Warehouse

Bunck, C.M.; Winterstein, S.R.; Pollock, K.H.

1985-01-01

Telemetry techniques can be used to study the survival rates of animal populations and are particularly suitable for species or settings for which band recovery models are not. Statistical methods for estimating survival rates and parameters of survival distributions from observations of radio-tagged animals will be described. These methods have been applied to medical and engineering studies and to the study of nest success. Estimates and tests based on discrete models, originally introduced by Mayfield, and on continuous models, both parametric and nonparametric, will be described. Generalizations, including staggered entry of subjects into the study and identification of mortality factors will be considered. Additional discussion topics will include sample size considerations, relocation frequency for subjects, and use of covariates.

Health Care Merged With Senior Housing: Description and Evaluation of a Successful Program.

PubMed

Barry, Theresa Teta

2017-01-01

Objective: This article describes and evaluates a successful partnership between a large health care organization and housing for seniors. The program provides on-site, primary care visits by a physician and a nurse in addition to intensive social services to residents in an affordable senior housing apartment building located in Pennsylvania. Per Donabedian's "Structure-Process-Outcome" model, the program demonstrated positive health care outcomes for its participants via a prescribed structure. To provide guidance for replication in similar settings, we qualitatively evaluated the processes by which successful outcomes were obtained. Methods: With program structures in place and outcomes measured, this case study collected and analyzed qualitative information taken from key informant interviews on care processes involved in the program. Themes were extracted from semistructured interviews and used to describe the processes that helped and hindered the program. Results and Discussion: Common processes were identified across respondents; however, the nuanced processes that lead to successful outcomes suggest that defined structures and processes may not be sufficient to produce similar outcomes in other settings. Further research is needed to determine the program's replicability and policy implications.

Approach of describing dynamic production of volatile fatty acids from sludge alkaline fermentation.

PubMed

Wang, Dongbo; Liu, Yiwen; Ngo, Huu Hao; Zhang, Chang; Yang, Qi; Peng, Lai; He, Dandan; Zeng, Guangming; Li, Xiaoming; Ni, Bing-Jie

2017-08-01

In this work, a mathematical model was developed to describe the dynamics of fermentation products in sludge alkaline fermentation systems for the first time. In this model, the impacts of alkaline fermentation on sludge disintegration, hydrolysis, acidogenesis, acetogenesis, and methanogenesis processes are specifically considered for describing the high-level formation of fermentation products. The model proposed successfully reproduced the experimental data obtained from five independent sludge alkaline fermentation studies. The modeling results showed that alkaline fermentation largely facilitated the disintegration, acidogenesis, and acetogenesis processes and severely inhibited methanogenesis process. With the pH increase from 7.0 to 10.0, the disintegration, acidogenesis, and acetogenesis processes respectively increased by 53%, 1030%, and 30% while methane production decreased by 3800%. However, no substantial effect on hydrolysis process was found. The model also indicated that the pathway of acetoclastic methanogenesis was more severely inhibited by alkaline condition than that of hydrogentrophic methanogenesis. Copyright © 2017 Elsevier Ltd. All rights reserved.

A grounded theory of successful aging among select incarcerated older Filipino women.

PubMed

Lucas, Heizel Mae; Lozano, Carl James; Valdez, Les Paul; Manzarate, Rowena; Lumawag, Fortuna Angelli Jolyn

Across the literature, impairment and disability among the older people have been associated with a decline in meeting their special needs. Failure in meeting such needs may cause deterioration of function and threaten successful aging. Accordingly, successful aging studies were carried out among males, in health care institutions, and in communities. In spite of these, the process by which successful aging is experienced by incarcerated older women remains to be a blank spot in research. This study purports to describe the process by which incarcerated older Filipino women experience successful aging. Strauss and Corbin's grounded theory design was employed. Semistructured interviews were conducted among 15 purposively selected incarcerated older Filipino from a Philippine penal institution exclusive for women. Further, data gathered was reduced to field text and was analyzed through open, axial and selective coding. Finally, truthfulness and trustworthiness of the findings were established through member checking. The study generated "The Road to Success Model". Interestingly, five phases relative to successful aging emerged, namely: Struggling, Remotivating, Reforming, Reintegrating and Sustaining. These phases describe how select incarcerated older Filipino women undergo transformation towards successful aging. Similar to a road, each phase is considered a station where one must pass through in order to get to the destination. Findings of the study serve as an impetus for structural and procedural changes in prison, with a view to providing an environment conducive to successful aging and appropriate recognition to the older prisoner's efforts to achieve successful aging. Copyright © 2018 Elsevier B.V. All rights reserved.

A second generation distributed point polarizable water model.

PubMed

Kumar, Revati; Wang, Fang-Fang; Jenness, Glen R; Jordan, Kenneth D

2010-01-07

A distributed point polarizable model (DPP2) for water, with explicit terms for charge penetration, induction, and charge transfer, is introduced. The DPP2 model accurately describes the interaction energies in small and large water clusters and also gives an average internal energy per molecule and radial distribution functions of liquid water in good agreement with experiment. A key to the success of the model is its accurate description of the individual terms in the n-body expansion of the interaction energies.

Giant Planet Formation

NASA Astrophysics Data System (ADS)

D'Angelo, G.; Durisen, R. H.; Lissauer, J. J.

2010-12-01

Gas giant planets play a fundamental role in shaping the orbital architecture of planetary systems and in affecting the delivery of volatile materials to terrestrial planets in the habitable zones. Current theories of gas giant planet formation rely on either of two mechanisms: the core accretion model and the disk instability model. In this chapter, we describe the essential principles upon which these models are built and discuss the successes and limitations of each model in explaining observational data of giant planets orbiting the Sun and other stars.

Strategy Guideline. Modeling Enclosure Design in Above-Grade Walls

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. Lstiburek; Ueno, K.; Musunuru, S.

2016-02-01

The Strategy Guideline, written by the U.S. Department of Energy's research team Building Science Corporation, 1) describes how to model and interpret results of models for above-grade walls, and 2) analyzes the failure thresholds and criteria for above-grade walls. A library of above-grade walls with historically successful performance was used to calibrate WUFI (Wärme und Feuchte instationär) software models. The information is generalized for application to a broad population of houses within the limits of existing experience.

Open source molecular modeling.

PubMed

Pirhadi, Somayeh; Sunseri, Jocelyn; Koes, David Ryan

2016-09-01

The success of molecular modeling and computational chemistry efforts are, by definition, dependent on quality software applications. Open source software development provides many advantages to users of modeling applications, not the least of which is that the software is free and completely extendable. In this review we categorize, enumerate, and describe available open source software packages for molecular modeling and computational chemistry. An updated online version of this catalog can be found at https://opensourcemolecularmodeling.github.io. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

LULL(ed) into complacency: a perspective on licenses and stem cell translational science

PubMed Central

2013-01-01

The US has had a very successful model for facilitating the translation of a basic discovery to a commercial application. The success of the model has hinged on providing clarity on ownership of a discovery, facilitating the licensing process, providing adequate incentive to the inventors, and developing a self-sustaining model for reinvestment. In recent years, technological, political, and regulatory changes have put strains on this model and in some cases have hindered progress rather than facilitated it. This is particularly true for the nascent field of regenerative medicine. To illustrate this, I will describe the contributing practices of several different entities, including universities, repositories, patent trolls, and service providers. It is my hope that the scientific community will be motivated to coordinate efforts against these obstacles to translation. PMID:23953837

The Red River College model: enhancing success of Native Canadian and other nursing students from disenfranchised groups.

PubMed

Labun, Evelyn

2002-10-01

The recruitment and retention of students from culturally diverse backgrounds remains a critical issue in nursing education. This article describes one program that was very successful in helping Native Canadian and other disenfranchised students succeed academically in nursing. The program design and operation as well as issues related to recruitment and retention of these students are presented. Many aspects of this program are now incorporated into the baccalaureate nursing program in the college.

A Study of Simulation Effectiveness in Modeling Heavy Combined Arms Combat in Urban Environments

DTIC Science & Technology

2007-05-01

Printing Office, 1987), 51. 2The old FM 17-15 (Tank Platoon) described bypassing urban areas. The new manual, FM 3-20.15 (dtd. 22 February 2007...hardened positions and counter the German’s crew-served weapons and armored counter-attacks.15 In addition to the moderately successful M4 tanks...the successful urban operations since and during WWII, it involved the use of heavy armor and combined arms. When the NVA and Vietcong captured Hue

Outsourcing to China.

PubMed

Liu, Jacqueline

2004-12-01

To enhance competitive advantage in the face of increasing globalisation, companies need to consider moving certain operations to China, if they have not done so already. This article describes the evolving nature of outsourcing to China and what companies need to consider to be successful in this business model.

Rethinking Partnerships on a Decentralized Campus

ERIC Educational Resources Information Center

Dufault, Katie H.

2017-01-01

Decentralization is an effective approach for structuring campus learning and success centers. McShane & Von Glinow (2007) describe decentralization as "an organizational model where decision authority and power are dispersed among units rather than held by a single small group of administrators" (p. 237). A decentralized structure…

Understanding Faculty Needs: An Institutional Imperative.

ERIC Educational Resources Information Center

O'Hara, Leonard F.

1996-01-01

Describes the importance of obtaining faculty support to ensure success in college reform efforts, and reviews strategies for improving institutional climate. Discusses a survey instrument designed to measure faculty perceptions of college atmosphere and developed as part of the Fourth Paradigm Governance Model. Includes a sample faculty…

Parent-Aided Homework: A Working Model for School Personnel.

ERIC Educational Resources Information Center

Harris, James R.

1983-01-01

Describes Parent-Aided Homework, a behavior modification program designed to encourage parent involvement in their child's homework. The PAH plan stresses positive reinforcement for successfully completed homework assignments. Parents enforce the agreed-on time limits and provide extra learning experiences and rewards. (JAC)

Methods to Promote Germination of Dormant Setaria viridis Seeds

PubMed Central

Sebastian, Jose; Wong, Mandy Ka; Tang, Evan; Dinneny, José R.

2014-01-01

Setaria viridis has recently emerged as a promising genetic model system to study diverse aspects of monocot biology. While the post-germination life cycle of S. viridis is approximately 8 weeks long, the prolonged dormancy of freshly harvested seeds can more than double the total time required between successive generations. Here we describe methods that promote seed germination in S. viridis. Our results demonstrate that treating S. viridis seeds with liquid smoke or a GA3 and KNO3 solution improves germination rates to 90% or higher even in seeds that are 6 days post-harvest with similar results obtained whether seeds are planted in soil or on gel-based media. Importantly, we show that these treatments have no significant effect on the growth of the adult plant. We have tested these treatments on diverse S. viridis accessions and show variation in their response. The methods described here will help advance research using this model grass species by increasing the pace at which successive generations of plants can be analyzed. PMID:24748008

Preparing Nursing Students for Interprofessional Practice: The Interdisciplinary Curriculum for Oncology Palliative Care Education.

PubMed

Hermann, Carla P; Head, Barbara A; Black, Karen; Singleton, Karen

2016-01-01

Interprofessional educational experiences for baccalaureate nursing students are essential to prepare them for interprofessional communication, collaboration, and team work. Nurse educators are ideally positioned to develop and lead such initiatives. The purpose of this article is to describe the development and implementation of an interprofessional education (IPE) project involving students in nursing, medicine, social work, and chaplaincy. The Interdisciplinary Curriculum for Oncology Palliative Care Education project uses team-based palliative oncology education as the framework for teaching students interprofessional practice skills. The need for IPE is apparent, but there are very few comprehensive, successful projects for nurse educators to use as models. This article describes the development of the curriculum by the interprofessional faculty team. Issues encountered by nursing faculty members as they implemented the IPE experience are discussed. Solutions developed to address the issues and ongoing challenges are presented. This project can serve as a model of a successful IPE initiative involving nursing students. Copyright © 2016 Elsevier Inc. All rights reserved.

A Fast MHD Code for Gravitationally Stratified Media using Graphical Processing Units: SMAUG

NASA Astrophysics Data System (ADS)

Griffiths, M. K.; Fedun, V.; Erdélyi, R.

2015-03-01

Parallelization techniques have been exploited most successfully by the gaming/graphics industry with the adoption of graphical processing units (GPUs), possessing hundreds of processor cores. The opportunity has been recognized by the computational sciences and engineering communities, who have recently harnessed successfully the numerical performance of GPUs. For example, parallel magnetohydrodynamic (MHD) algorithms are important for numerical modelling of highly inhomogeneous solar, astrophysical and geophysical plasmas. Here, we describe the implementation of SMAUG, the Sheffield Magnetohydrodynamics Algorithm Using GPUs. SMAUG is a 1-3D MHD code capable of modelling magnetized and gravitationally stratified plasma. The objective of this paper is to present the numerical methods and techniques used for porting the code to this novel and highly parallel compute architecture. The methods employed are justified by the performance benchmarks and validation results demonstrating that the code successfully simulates the physics for a range of test scenarios including a full 3D realistic model of wave propagation in the solar atmosphere.

Linking genotoxic responses and reproductive success in ecotoxicology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, S.L.; Wild, G.C.

1994-12-01

The potential of genotoxicity biomarkers as predictors of detrimental environmental effects, such as altered reproductive success of wild organisms, must be rigorously determined. Recent research to evaluate relationships between genotoxic responses and indicators of reproductive success in model animals is described from an ecotoxicological perspective. Genotoxicity can be correlated with reproductive effects such as gamete loss due to cell death; embryonic mortality; and heritable mutations in a range of model animals including polychaete worms, nematodes, sea urchins, amphibians, and fish. In preliminary studies, the polychaete worm, Neanthes arenaceodentata, and the nematode, Caenorhabditis elegans, have also shown the potential for cumulativemore » DNA damage in gametes. If DNA repair capacity is limited in gametes, then selected life history traits such as long and synchronous periods of gametogenesis may confer vulnerability to genotoxic substances in chronic exposures. Recommendations for future research include strategic development of animal models that can be used to elucidate multiple mechanisms of effect (multiend point) at varying levels of biological organization (multilevel). 27 refs., 2 tabs.« less

Crazing in Polymeric and Composite Systems

DTIC Science & Technology

1990-04-23

these physical variations into consideration in any mathematical modeling and formulation in analyzing the stresses from the time when crazes incept to...as boundary tractions with great strength; any governing mathematical formulation must include this feature for any adequate analysis. Crazes of...constants the mathematical model describing the crazing mechanism have been successful [25-29]. References 1 J. A. Sauer, J. Marin and C. C. Hsiao, J. App

The Idaho dedicated education unit model: cost-effective, high-quality education.

PubMed

Springer, Pamela J; Johnson, Patricia; Lind, Bonnie; Walker, Eldon; Clavelle, Joanne; Jensen, Nancy

2012-01-01

Faculty face many challenges in delivering clinical education, including faculty availability, the complexity of the faculty role, and limited clinical placements. Dedicated education units (DEUs) are being explored as alternatives to traditional clinical placement models. The authors describe the successful development of a DEU that resulted in positive student outcomes at reduced cost to both the school and the medical center.

Facilitating superior chronic disease management through a knowledge-based systems development model.

PubMed

Wickramasinghe, Nilmini S; Goldberg, Steve

2008-01-01

To date, the adoption and diffusion of technology-enabled solutions to deliver better healthcare has been slow. There are many reasons for this. One of the most significant is that the existing methodologies that are normally used in general for Information and Communications Technology (ICT) implementations tend to be less successful in a healthcare context. This paper describes a knowledge-based adaptive mapping to realisation methodology to traverse successfully from idea to realisation rapidly and without compromising rigour so that success ensues. It is discussed in connection with trying to implement superior ICT-enabled approaches to facilitate superior Chronic Disease Management (CDM).

Effects of selective attention on continuous opinions and discrete decisions

NASA Astrophysics Data System (ADS)

Si, Xia-Meng; Liu, Yun; Xiong, Fei; Zhang, Yan-Chao; Ding, Fei; Cheng, Hui

2010-09-01

Selective attention describes that individuals have a preference on information according to their involving motivation. Based on achievements of social psychology, we propose an opinion interacting model to improve the modeling of individuals’ interacting behaviors. There are two parameters governing the probability of agents interacting with opponents, i.e. individual relevance and time-openness. It is found that, large individual relevance and large time-openness advance the appearance of large clusters, but large individual relevance and small time-openness favor the lessening of extremism. We also put this new model into application to work out some factor leading to a successful product. Numerical simulations show that selective attention, especially individual relevance, cannot be ignored by launcher firms and information spreaders so as to attain the most successful promotion.

Strategic planning: a biomedical communications model.

PubMed

Barrett, J E

1991-01-01

This article describes a biomedical communications approach to strategic planning. This model produces a short-term plan that allows a department to take the competitive advantage, react to technological change, and make timely decisions on new courses of action. The model calls for self-study, involving staff in brainstorming sessions where options are identified and ideas are prioritized into possible strategies for success. The article recommends that an evaluation and monitoring schedule be implemented after decisions have been made.

A quantum-like model of homeopathy clinical trials: importance of in situ randomization and unblinding.

PubMed

Beauvais, Francis

2013-04-01

The randomized controlled trial (RCT) is the 'gold standard' of modern clinical pharmacology. However, for many practitioners of homeopathy, blind RCTs are an inadequate research tool for testing complex therapies such as homeopathy. Classical probabilities used in biological sciences and in medicine are only a special case of the generalized theory of probability used in quantum physics. I describe homeopathy trials using a quantum-like statistical model, a model inspired by quantum physics and taking into consideration superposition of states, non-commuting observables, probability interferences, contextuality, etc. The negative effect of blinding on success of homeopathy trials and the 'smearing effect' ('specific' effects of homeopathy medicine occurring in the placebo group) are described by quantum-like probabilities without supplementary ad hoc hypotheses. The difference of positive outcome rates between placebo and homeopathy groups frequently vanish in centralized blind trials. The model proposed here suggests a way to circumvent such problems in masked homeopathy trials by incorporating in situ randomization/unblinding. In this quantum-like model of homeopathy clinical trials, success in open-label setting and failure with centralized blind RCTs emerge logically from the formalism. This model suggests that significant differences between placebo and homeopathy in blind RCTs would be found more frequently if in situ randomization/unblinding was used. Copyright © 2013. Published by Elsevier Ltd.

Modeling Human Exposure to Indoor Contaminants: External Source to Body Tissues.

PubMed

Webster, Eva M; Qian, Hua; Mackay, Donald; Christensen, Rebecca D; Tietjen, Britta; Zaleski, Rosemary

2016-08-16

Information on human indoor exposure is necessary to assess the potential risk to individuals from many chemicals of interest. Dynamic indoor and human physicologically based pharmacokinetic (PBPK) models of the distribution of nonionizing, organic chemical concentrations in indoor environments resulting in delivered tissue doses are developed, described and tested. The Indoor model successfully reproduced independently measured, reported time-dependent air concentrations of chloroform released during showering and of 2-butyoxyethanol following use of a volatile surface cleaner. The Indoor model predictions were also comparable to those from a higher tier consumer model (ConsExpo 4.1) for the surface cleaner scenario. The PBPK model successful reproduced observed chloroform exhaled air concentrations resulting from an inhalation exposure. Fugacity based modeling provided a seamless description of the partitioning, fluxes, accumulation and release of the chemical in indoor media and tissues of the exposed subject. This has the potential to assist in health risk assessments, provided that appropriate physical/chemical property, usage characteristics, and toxicological information are available.

Toward the Application of the Implicit Particle Filter to Real Data in a Shallow Water Model of the Nearshore Ocean

NASA Astrophysics Data System (ADS)

Miller, R.

2015-12-01

Following the success of the implicit particle filter in twin experiments with a shallow water model of the nearshore environment, the planned next step is application to the intensive Sandy Duck data set, gathered at Duck, NC. Adaptation of the present system to the Sandy Duck data set will require construction and evaluation of error models for both the model and the data, as well as significant modification of the system to allow for the properties of the data set. Successful implementation of the particle filter promises to shed light on the details of the capabilities and limitations of shallow water models of the nearshore ocean relative to more detailed models. Since the shallow water model admits distinct dynamical regimes, reliable parameter estimation will be important. Previous work by other groups give cause for optimism. In this talk I will describe my progress toward implementation of the new system, including problems solved, pitfalls remaining and preliminary results

Education Reform as if Student Agency Mattered: Academic Microcultures and Student Identity.

ERIC Educational Resources Information Center

Jackson, D. Bruce

2003-01-01

Argues that identity-sensitive education, focused on improving students' attitudes and beliefs about their own learning, is essential for academic success. Describes three models of identity-sensitive education: charismatic teacher, "together we'll make it," and "intellectual hothouse." Identifies common characteristics of…

Getting into Film.

ERIC Educational Resources Information Center

London, Mel

This book describes the various aspects of the film industry and the many jobs related to filmmaking, stressing that no "formula" exists for finding a successful career in the film industry. Chapters provide information on production, writing for film, cinematography, editing, music, sound, animation and graphics, acting and modeling, the "unsung…

Patterns of Excellence: Promoting Quality in Teaching through Diversity.

ERIC Educational Resources Information Center

Jackson Nathaniel, Ed.; Bolden, Wiley S., Ed.; Fenwick, Leslie T., Ed.

This collection of papers describes pre-collegiate and collegiate programs that are models for successful minority teacher recruitment and preparation. The papers include: "Correcting the Minority Teacher Shortage: Framing the Issue, Meeting the Challenge" (Elaine P. Witty); "Response of the Southern Education Foundation to the…

Explorations in Integrated Science

ERIC Educational Resources Information Center

Lega, Joceline C.; Buxner, Sanlyn; Blonder, Benjamin; Tama, Florence

2014-01-01

We describe a third-year undergraduate course that focuses on multiscale modeling and protein folding and has as its primary goal the encouragement of students to integrate thinking across and beyond disciplinary boundaries. The ability to perform innovative and successful research work in STEM (science, technology, engineering, and mathematics)…

Library Literacy Programs for English Language Learners. ERIC Digest.

ERIC Educational Resources Information Center

McMurrer, Eileen; Terrill, Lynda

This digest summarizes the history of public libraries and library literacy programs; describes current delivery models; and discusses initiatives in library literacy, profiling one successful public library program that serves adult English language learners and their families. (Adjunct ERIC Clearinghouse for ESL Literacy Education) (Author/VWL)

A model of cause—effect relations in the study of behavior

PubMed Central

Chisholm, Drake C.; Cook, Donald A.

1995-01-01

A three-phase model useful in teaching the analysis of behavior is presented. The model employs a “black box” behavior inventory diagram (BID), with a single output arrow representing behavior and three input arrows representing stimulus field, reversible states, and conditioning history. The first BID describes the organism at Time 1, and the second describes it at Time 2. Separating the two inventory diagrams is a column for the description of the intervening procedure. The model is used as a one-page handout, and students fill in the corresponding empty areas on the sheet as they solve five types of application problems. Instructors can use the BID to shape successive approximations in the accurate use of behavior-analytic vocabulary, conceptual analysis, and applications of behavior-change strategies. PMID:22478209

Interprofessional collaboration: three best practice models of interprofessional education

PubMed Central

Bridges, Diane R.; Davidson, Richard A.; Odegard, Peggy Soule; Maki, Ian V.; Tomkowiak, John

2011-01-01

Interprofessional education is a collaborative approach to develop healthcare students as future interprofessional team members and a recommendation suggested by the Institute of Medicine. Complex medical issues can be best addressed by interprofessional teams. Training future healthcare providers to work in such teams will help facilitate this model resulting in improved healthcare outcomes for patients. In this paper, three universities, the Rosalind Franklin University of Medicine and Science, the University of Florida and the University of Washington describe their training curricula models of collaborative and interprofessional education. The models represent a didactic program, a community-based experience and an interprofessional-simulation experience. The didactic program emphasizes interprofessional team building skills, knowledge of professions, patient centered care, service learning, the impact of culture on healthcare delivery and an interprofessional clinical component. The community-based experience demonstrates how interprofessional collaborations provide service to patients and how the environment and availability of resources impact one's health status. The interprofessional-simulation experience describes clinical team skills training in both formative and summative simulations used to develop skills in communication and leadership. One common theme leading to a successful experience among these three interprofessional models included helping students to understand their own professional identity while gaining an understanding of other professional's roles on the health care team. Commitment from departments and colleges, diverse calendar agreements, curricular mapping, mentor and faculty training, a sense of community, adequate physical space, technology, and community relationships were all identified as critical resources for a successful program. Summary recommendations for best practices included the need for administrative support, interprofessional programmatic infrastructure, committed faculty, and the recognition of student participation as key components to success for anyone developing an IPE centered program. PMID:21519399

Interprofessional collaboration: three best practice models of interprofessional education.

PubMed

Bridges, Diane R; Davidson, Richard A; Odegard, Peggy Soule; Maki, Ian V; Tomkowiak, John

2011-04-08

Interprofessional education is a collaborative approach to develop healthcare students as future interprofessional team members and a recommendation suggested by the Institute of Medicine. Complex medical issues can be best addressed by interprofessional teams. Training future healthcare providers to work in such teams will help facilitate this model resulting in improved healthcare outcomes for patients. In this paper, three universities, the Rosalind Franklin University of Medicine and Science, the University of Florida and the University of Washington describe their training curricula models of collaborative and interprofessional education.The models represent a didactic program, a community-based experience and an interprofessional-simulation experience. The didactic program emphasizes interprofessional team building skills, knowledge of professions, patient centered care, service learning, the impact of culture on healthcare delivery and an interprofessional clinical component. The community-based experience demonstrates how interprofessional collaborations provide service to patients and how the environment and availability of resources impact one's health status. The interprofessional-simulation experience describes clinical team skills training in both formative and summative simulations used to develop skills in communication and leadership.One common theme leading to a successful experience among these three interprofessional models included helping students to understand their own professional identity while gaining an understanding of other professional's roles on the health care team. Commitment from departments and colleges, diverse calendar agreements, curricular mapping, mentor and faculty training, a sense of community, adequate physical space, technology, and community relationships were all identified as critical resources for a successful program. Summary recommendations for best practices included the need for administrative support, interprofessional programmatic infrastructure, committed faculty, and the recognition of student participation as key components to success for anyone developing an IPE centered program.

Integrating empowerment evaluation and quality improvement to achieve healthcare improvement outcomes.

PubMed

Wandersman, Abraham; Alia, Kassandra Ann; Cook, Brittany; Ramaswamy, Rohit

2015-10-01

While the body of evidence-based healthcare interventions grows, the ability of health systems to deliver these interventions effectively and efficiently lags behind. Quality improvement approaches, such as the model for improvement, have demonstrated some success in healthcare but their impact has been lessened by implementation challenges. To help address these challenges, we describe the empowerment evaluation approach that has been developed by programme evaluators and a method for its application (Getting To Outcomes (GTO)). We then describe how GTO can be used to implement healthcare interventions. An illustrative healthcare quality improvement example that compares the model for improvement and the GTO method for reducing hospital admissions through improved diabetes care is described. We conclude with suggestions for integrating GTO and the model for improvement. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Exploiting distant homologues for phasing through the generation of compact fragments, local fold refinement and partial solution combination.

PubMed

Millán, Claudia; Sammito, Massimo Domenico; McCoy, Airlie J; Nascimento, Andrey F Ziem; Petrillo, Giovanna; Oeffner, Robert D; Domínguez-Gil, Teresa; Hermoso, Juan A; Read, Randy J; Usón, Isabel

2018-04-01

Macromolecular structures can be solved by molecular replacement provided that suitable search models are available. Models from distant homologues may deviate too much from the target structure to succeed, notwithstanding an overall similar fold or even their featuring areas of very close geometry. Successful methods to make the most of such templates usually rely on the degree of conservation to select and improve search models. ARCIMBOLDO_SHREDDER uses fragments derived from distant homologues in a brute-force approach driven by the experimental data, instead of by sequence similarity. The new algorithms implemented in ARCIMBOLDO_SHREDDER are described in detail, illustrating its characteristic aspects in the solution of new and test structures. In an advance from the previously published algorithm, which was based on omitting or extracting contiguous polypeptide spans, model generation now uses three-dimensional volumes respecting structural units. The optimal fragment size is estimated from the expected log-likelihood gain (LLG) values computed assuming that a substructure can be found with a level of accuracy near that required for successful extension of the structure, typically below 0.6 Å root-mean-square deviation (r.m.s.d.) from the target. Better sampling is attempted through model trimming or decomposition into rigid groups and optimization through Phaser's gyre refinement. Also, after model translation, packing filtering and refinement, models are either disassembled into predetermined rigid groups and refined (gimble refinement) or Phaser's LLG-guided pruning is used to trim the model of residues that are not contributing signal to the LLG at the target r.m.s.d. value. Phase combination among consistent partial solutions is performed in reciprocal space with ALIXE. Finally, density modification and main-chain autotracing in SHELXE serve to expand to the full structure and identify successful solutions. The performance on test data and the solution of new structures are described.

Toward a More Comprehensive Concept of Successful Aging: Disability and Care Needs

PubMed Central

Wahl, Hans-Werner

2017-01-01

Abstract Rowe and Kahn’s model of Successful Aging 2.0 argues that changing environmental settings, societal policies, and individual life styles will lead to a significant extension of healthy life years. Recent epidemiological research, however, confirms the dilemma that the ongoing extension of life expectancy prolongs not only the years in good health but also those in poor health. We see it as a major limitation that Rowe and Kahn’s model is not able to cover the emerging linkage between increasing life expectation and aging with disability and care needs. Therefore, we suggest a set of propositions towards a more comprehensive model of successful aging which captures desirable living situations including for those who grow old with disabilities and care needs. We describe individual, environmental, and care related strategies and resources for autonomy and quality of life when facing disabilities and care needs in late life, putting emphasis on inter-individual differences and social inequality. We argue that expanding the traditional concept of successful aging to aging with disabilities and care needs serves not to undermine, but rather to anchor the concept in aging science and in public perception. PMID:27988482

Take the Reins on Model Quality with ModelCHECK and Gatekeeper

NASA Technical Reports Server (NTRS)

Jones, Corey

2012-01-01

Model quality and consistency has been an issue for us due to the diverse experience level and imaginative modeling techniques of our users. Fortunately, setting up ModelCHECK and Gatekeeper to enforce our best practices has helped greatly, but it wasn't easy. There were many challenges associated with setting up ModelCHECK and Gatekeeper including: limited documentation, restrictions within ModelCHECK, and resistance from end users. However, we consider ours a success story. In this presentation we will describe how we overcame these obstacles and present some of the details of how we configured them to work for us.

A successful model for longitudinal community-engaged health research: the 2040 Partners for Health Student Program.

PubMed

Redman, Romany M; Reinsvold, Magdalena C; Reddy, Anireddy; Bennett, Paige E; Hoerauf, Janine M; Puls, Kristina M; Ovrutsky, Alida R; Ly, Alexandra R; White, Gregory; McNeil, Owetta; Meredith, Janet J

2017-06-01

Community-based participatory research [CBPR] is an emerging approach to collaborative research aimed at creating locally effective and sustainable interventions. The 2040 Partners for Health student program was developed as a unique model of longitudinal CBPR. Analysis of this program and its components illuminates both the challenges and the opportunities inherent in community engagement. The program rests on a foundation of a community-based, non-profit organization and a supportive academic university centre. Inter-professional health students and community members of underserved populations work together on different health projects by employing an adapted CBPR methodology. Three successful examples of sustainable CBPR projects are briefly described. The three projects are presented as primary outcomes resulting from this model. Benefits and challenges of the model as an approach to community-engaged research are discussed as well as secondary benefits of student participation. The 2040 Partners for Health student program represents a successful model of CBPR, illuminating common challenges and reiterating the profound value of community-engaged research. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

“I’m still raring to go”: Successful Aging Among Lesbian, Gay, Bisexual, and Transgender Older Adults

PubMed Central

Driskell, Jeff; Bradford, Judith

2012-01-01

While we know that minority status differentiates the experience of aging, little research has been done to examine the ways in which patterns of successful aging may differ in diverse subgroups of older adults. In this exploratory study, we investigated and described experiences of successful aging in a sample of lesbian, gay, bisexual and transgender (LGBT) older adults. Directed by a community-based participatory research process, we conducted semi-structured in-depth interviews with 22 LGBT adults, age 60 and older. We took an inductive, grounded theory approach to analyze the taped and transcribed interviews. We coded respondent experiences in four domains: physical health, mental health, emotional state and social engagement. Four gradations of successful aging emerged. Very few in our sample met the bar for “traditional success” characterized by the absence of problems in all four domains of health. Most of the sample was coping to a degree with problems and were categorized in one of two gradations on a continuum of successful aging: “surviving and thriving” and “working at it.” A small number was “ailing”: not coping well with problems. Some of the experiences that respondents described were related to LGBT status; others were related to more general processes of aging. The research suggests that a successful aging framework that is modified to include coping can better describe the experiences of LGBT older adults. The modified conceptual model outlined here may be useful in future research on this population, as well as more broadly for diverse populations of adults, and may be adapted for use in practice to assess and improve health and well-being. PMID:23273552

Sources of variation in survival of breeding female wood ducks

USGS Publications Warehouse

Hartke, Kevin M.; Grand, J.B.; Hepp, G.R.; Folk, T.H.

2006-01-01

In waterfowl, reproduction is physiologically demanding and females are exposed to varying risks of mortality at different periods of the breeding cycle. Moreover, differences among females may influence survival within breeding periods. We captured and fitted female Wood Ducks (Aix sponsa) with radio-transmitters before nest initiation during two breeding seasons to estimate survival and investigate sources of variation in survival. We partitioned the breeding season into three periods (preincubation, incubation, postnesting) according to breeding status of individual females, and used information-theoretic methods to compare models in which daily survival varied among periods, between successful and failed nesting females, and with parameters describing individual heterogeneity. Our analysis suggested that daily survival was best modeled as a function of breeding period, differences between successful and failed nesting females during postnesting, and early incubation body condition of successful females during post-nesting. Model-averaged daily survival was 0.9988 (95% CL: 0.9963-0.9996) during preincubation and 1.0 during incubation. Postnesting daily survival was 1.0 for failed nesting females and 0.9948 (0.9773-0.9988) for successful females, suggesting a trade-off between current reproduction and survival. Female age, body condition at capture, nest initiation date, and brood size generally were not useful for explaining variation in survival. Only early incubation body condition was important for modeling survival of successful females during postnesting; however, weight of evidence was limited and the effect on survival was weak. Mortality was greatest for females during preincubation and for females that nested successfully. Results support the hypothesis that brood care is costly for females. ?? The Cooper Ornithological Society 2006.

An investigation of modelling and design for software service applications.

PubMed

Anjum, Maria; Budgen, David

2017-01-01

Software services offer the opportunity to use a component-based approach for the design of applications. However, this needs a deeper understanding of how to develop service-based applications in a systematic manner, and of the set of properties that need to be included in the 'design model'. We have used a realistic application to explore systematically how service-based designs can be created and described. We first identified the key properties of an SOA (service oriented architecture) and then undertook a single-case case study to explore its use in the development of a design for a large-scale application in energy engineering, modelling this with existing notations wherever possible. We evaluated the resulting design model using two walkthroughs with both domain and application experts. We were able to successfully develop a design model around the ten properties identified, and to describe it by adapting existing design notations. A component-based approach to designing such systems does appear to be feasible. However, it needs the assistance of a more integrated set of notations for describing the resulting design model.

Information for Successful Interaction with Autonomous Systems

NASA Technical Reports Server (NTRS)

Malin, Jane T.; Johnson, Kathy A.

2003-01-01

Interaction in heterogeneous mission operations teams is not well matched to classical models of coordination with autonomous systems. We describe methods of loose coordination and information management in mission operations. We describe an information agent and information management tool suite for managing information from many sources, including autonomous agents. We present an integrated model of levels of complexity of agent and human behavior, which shows types of information processing and points of potential error in agent activities. We discuss the types of information needed for diagnosing problems and planning interactions with an autonomous system. We discuss types of coordination for which designs are needed for autonomous system functions.

Measuring and modeling salience with the theory of visual attention.

PubMed

Krüger, Alexander; Tünnermann, Jan; Scharlau, Ingrid

2017-08-01

For almost three decades, the theory of visual attention (TVA) has been successful in mathematically describing and explaining a wide variety of phenomena in visual selection and recognition with high quantitative precision. Interestingly, the influence of feature contrast on attention has been included in TVA only recently, although it has been extensively studied outside the TVA framework. The present approach further develops this extension of TVA's scope by measuring and modeling salience. An empirical measure of salience is achieved by linking different (orientation and luminance) contrasts to a TVA parameter. In the modeling part, the function relating feature contrasts to salience is described mathematically and tested against alternatives by Bayesian model comparison. This model comparison reveals that the power function is an appropriate model of salience growth in the dimensions of orientation and luminance contrast. Furthermore, if contrasts from the two dimensions are combined, salience adds up additively.

Experience With Bayesian Image Based Surface Modeling

NASA Technical Reports Server (NTRS)

Stutz, John C.

2005-01-01

Bayesian surface modeling from images requires modeling both the surface and the image generation process, in order to optimize the models by comparing actual and generated images. Thus it differs greatly, both conceptually and in computational difficulty, from conventional stereo surface recovery techniques. But it offers the possibility of using any number of images, taken under quite different conditions, and by different instruments that provide independent and often complementary information, to generate a single surface model that fuses all available information. I describe an implemented system, with a brief introduction to the underlying mathematical models and the compromises made for computational efficiency. I describe successes and failures achieved on actual imagery, where we went wrong and what we did right, and how our approach could be improved. Lastly I discuss how the same approach can be extended to distinct types of instruments, to achieve true sensor fusion.

MoCog1: A computer simulation of recognition-primed human decision making

NASA Technical Reports Server (NTRS)

Gevarter, William B.

1991-01-01

This report describes the successful results of the first stage of a research effort to develop a 'sophisticated' computer model of human cognitive behavior. Most human decision-making is of the experience-based, relatively straight-forward, largely automatic, type of response to internal goals and drives, utilizing cues and opportunities perceived from the current environment. This report describes the development of the architecture and computer program associated with such 'recognition-primed' decision-making. The resultant computer program was successfully utilized as a vehicle to simulate findings that relate how an individual's implicit theories orient them toward particular goals, with resultant cognitions, affects, and behavior in response to their environment. The present work is an expanded version and is based on research reported while the author was an employee of NASA ARC.

The Fisk-Vanderbilt Masters-to-PhD Bridge Program: A Model for Broadening Participation of Underrepresented Groups in the Physical Sciences through Effective Partnerships with Minority-Serving Institutions

ERIC Educational Resources Information Center

Stassun, Keivan Guadalupe; Burger, Arnold; Lange, Sheila Edwards

2010-01-01

We describe the Fisk-Vanderbilt Masters-to-PhD Bridge program as a successful model for effective partnerships with minority-serving institutions toward significantly broadening the participation of underrepresented groups in the physical sciences. The program couples targeted recruitment with active retention strategies, and is built upon a…

Cooperative Search by UAV Teams: A Model Predictive Approach Using Dynamic Graphs

DTIC Science & Technology

2011-10-01

decentralized processing and control architecture. SLAMEM asset models accurately represent the Unicorn UAV platforms and other standard military platforms in...IMPLEMENTATION The CGBMPS algorithm has been successfully field-tested using both Unicorn [27] and Raven [20] UAV platforms. This section describes...the hardware-software system setup and implementation used for testing with Unicorns , Toyon’s UAV test platform. We also present some results from the

Irreversible thermodynamics of Poisson processes with reaction.

PubMed

Méndez, V; Fort, J

1999-11-01

A kinetic model is derived to study the successive movements of particles, described by a Poisson process, as well as their generation. The irreversible thermodynamics of this system is also studied from the kinetic model. This makes it possible to evaluate the differences between thermodynamical quantities computed exactly and up to second-order. Such differences determine the range of validity of the second-order approximation to extended irreversible thermodynamics.

Diffusing Innovations in Nursing Education: From PDAs to OERs.

PubMed

Doyle, Glynda; Budz, Bernice

2016-01-01

The Canadian educational and healthcare practice landscapes are ever-evolving technologically. In response to these changes, the British Columbia Institute of Technology (BCIT) has integrated various educational technologies using Rogers Diffusion of Innovation model as a guiding framework for this integration with considerable success. This poster describes BCIT's journey with diffusing innovations, discusses examples of these technological integrations in accordance with Roger's model, and outlines several implications for educational practice.

Molecular Modeling of Interfacial Behaviors of Nanomaterials

DTIC Science & Technology

2007-05-01

potential was originally designed for the modeling of mixed covalent- ionic bonding and was successfully used to describe oxides in crystalline, glassy, and...is separates from the bulk liquid polymer, i.e., the structure of this layer, as influenced by that of the meatal surface, is significantly more...Striolo, J. Kieffer, and P. Cummings, ’Evaluation of Force- fields for molecular simulation of polyhedral oligomeric silsesquioxanes,’ J. Phys. Chem

Next Step Toward Widespread Residential Deep Energy Retrofits

DOE Office of Scientific and Technical Information (OSTI.GOV)

McIlvaine, J.; Saunders, S.; Bordelon, E.

The complexity of deep energy retrofits warrants additional training to successfully manage multiple improvements that will change whole house air, heat, and moisture flow dynamics. The home performance contracting industry has responded to these challenges by aggregating skilled labor for assessment of and implementation under one umbrella. Two emerging business models are profiled that seek to resolve many of the challenges, weaknesses, opportunities, and threats described for the conventional business models.

Using Transgenic Zebrafish to Study Muscle Stem/Progenitor Cells.

PubMed

Nguyen, Phong D; Currie, Peter D

2017-01-01

Understanding muscle stem cell behaviors can potentially provide insights into how these cells act and respond during normal growth and diseased contexts. The zebrafish is an ideal model organism to examine these behaviors in vivo where it would normally be technically challenging in other mammalian models. This chapter will describe the procedures required to successfully conduct live imaging of zebrafish transgenics that has specifically been adapted for skeletal muscle.

Telehealth services in rural and remote Australia: a systematic review of models of care and factors influencing success and sustainability.

PubMed

Bradford, Natalie K; Caffery, Liam J; Smith, Anthony C

2016-01-01

With the escalating costs of health care, issues with recruitment and retention of health practitioners in rural areas, and poor economies of scale, the question of delivering people to services or services to people is a dilemma for health authorities around the world. People living in rural areas have poorer health outcomes compared to their urban counterparts, and the problem of how to provide health care and deliver services in rural locations is an ongoing challenge. Telehealth services can efficiently and effectively improve access to healthcare for people living in rural and remote areas of Australia. However, telehealth services are not mainstream or routinely available in many rural and remote locations. The barriers to integration of telehealth into mainstream practice have been well described, but not the factors that may influence the success and sustainability of a service. Our aim was to collate, review and synthesise the available literature regarding telehealth services in rural and remote locations of Australia, and to identify the factors associated with their sustained success. A systematic literature review of peer-reviewed and grey literature was undertaken. Electronic databases were searched for potentially relevant articles. Reference lists of retrieved articles and the grey literature were also searched. Searches identified 970 potentially eligible articles published between 1988 and 2015. Studies and manuscripts of any type were included if they described telehealth services (store-and-forward or real-time videoconferencing) to provide clinical service or education and training related to health care in rural or remote locations of Australia. Data were extracted according to pre-defined criteria and checked for completeness and accuracy by a second reviewer. Any disagreements were resolved with discussion with a third researcher. All articles were appraised for quality and levels of evidence. Data were collated and grouped into categories including clinical speciality, disciplines involved, geographical location and the role of the service. Data relating to the success or sustainability of services were grouped thematically. Inclusion criteria were met by 116 articles that described 72 discrete telehealth services. Telehealth services in rural and remote Australia are described and we have identified six key factors associated with the success and sustainability of services: vision, ownership, adaptability, economics, efficiency and equipment. Telehealth has the potential to address many of the key challenges to providing health in Australia, with its substantial land area and widely dispersed population. This review collates information regarding the telehealth services in Australia and describes models of care and characteristics of successful and sustainable services. We identified a wide variety of telehealth services being provided in rural and remote areas of Australia. There is great potential to increase this number by scaling up and replicating successful services. This review provides information for policy makers, governments and public and private health services that wish to integrate telehealth into routine practice and for telehealth providers to enhance the sustainability of their service.

Gaussian process-based surrogate modeling framework for process planning in laser powder-bed fusion additive manufacturing of 316L stainless steel

DOE PAGES

Tapia, Gustavo; Khairallah, Saad A.; Matthews, Manyalibo J.; ...

2017-09-22

Here, Laser Powder-Bed Fusion (L-PBF) metal-based additive manufacturing (AM) is complex and not fully understood. Successful processing for one material, might not necessarily apply to a different material. This paper describes a workflow process that aims at creating a material data sheet standard that describes regimes where the process can be expected to be robust. The procedure consists of building a Gaussian process-based surrogate model of the L-PBF process that predicts melt pool depth in single-track experiments given a laser power, scan speed, and laser beam size combination. The predictions are then mapped onto a power versus scan speed diagrammore » delimiting the conduction from the keyhole melting controlled regimes. This statistical framework is shown to be robust even for cases where experimental training data might be suboptimal in quality, if appropriate physics-based filters are applied. Additionally, it is demonstrated that a high-fidelity simulation model of L-PBF can equally be successfully used for building a surrogate model, which is beneficial since simulations are getting more efficient and are more practical to study the response of different materials, than to re-tool an AM machine for new material powder.« less

Use of statecharts in the modelling of dynamic behaviour in the ATLAS DAQ prototype-1

NASA Astrophysics Data System (ADS)

Croll, P.; Duval, P.-Y.; Jones, R.; Kolos, S.; Sari, R. F.; Wheeler, S.

1998-08-01

Many applications within the ATLAS DAQ prototype-1 system have complicated dynamic behaviour which can be successfully modelled in terms of states and transitions between states. Previously, state diagrams implemented as finite-state machines have been used. Although effective, they become ungainly as system size increases. Harel statecharts address this problem by implementing additional features such as hierarchy and concurrency. The CHSM object-oriented language system is freeware which implements Harel statecharts as concurrent, hierarchical, finite-state machines (CHSMs). An evaluation of this language system by the ATLAS DAQ group has shown it to be suitable for describing the dynamic behaviour of typical DAQ applications. The language is currently being used to model the dynamic behaviour of the prototype-1 run-control system. The design is specified by means of a CHSM description file, and C++ code is obtained by running the CHSM compiler on the file. In parallel with the modelling work, a code generator has been developed which translates statecharts, drawn using the StP CASE tool, into the CHSM language. C++ code, describing the dynamic behaviour of the run-control system, has been successfully generated directly from StP statecharts using the CHSM generator and compiler. The validity of the design was tested using the simulation features of the Statemate CASE tool.

Gaussian process-based surrogate modeling framework for process planning in laser powder-bed fusion additive manufacturing of 316L stainless steel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tapia, Gustavo; Khairallah, Saad A.; Matthews, Manyalibo J.

Here, Laser Powder-Bed Fusion (L-PBF) metal-based additive manufacturing (AM) is complex and not fully understood. Successful processing for one material, might not necessarily apply to a different material. This paper describes a workflow process that aims at creating a material data sheet standard that describes regimes where the process can be expected to be robust. The procedure consists of building a Gaussian process-based surrogate model of the L-PBF process that predicts melt pool depth in single-track experiments given a laser power, scan speed, and laser beam size combination. The predictions are then mapped onto a power versus scan speed diagrammore » delimiting the conduction from the keyhole melting controlled regimes. This statistical framework is shown to be robust even for cases where experimental training data might be suboptimal in quality, if appropriate physics-based filters are applied. Additionally, it is demonstrated that a high-fidelity simulation model of L-PBF can equally be successfully used for building a surrogate model, which is beneficial since simulations are getting more efficient and are more practical to study the response of different materials, than to re-tool an AM machine for new material powder.« less

A Framework for Modeling Emerging Diseases to Inform Management

PubMed Central

Katz, Rachel A.; Richgels, Katherine L.D.; Walsh, Daniel P.; Grant, Evan H.C.

2017-01-01

The rapid emergence and reemergence of zoonotic diseases requires the ability to rapidly evaluate and implement optimal management decisions. Actions to control or mitigate the effects of emerging pathogens are commonly delayed because of uncertainty in the estimates and the predicted outcomes of the control tactics. The development of models that describe the best-known information regarding the disease system at the early stages of disease emergence is an essential step for optimal decision-making. Models can predict the potential effects of the pathogen, provide guidance for assessing the likelihood of success of different proposed management actions, quantify the uncertainty surrounding the choice of the optimal decision, and highlight critical areas for immediate research. We demonstrate how to develop models that can be used as a part of a decision-making framework to determine the likelihood of success of different management actions given current knowledge. PMID:27983501

Tomographic imaging of non-local media based on space-fractional diffusion models

NASA Astrophysics Data System (ADS)

Buonocore, Salvatore; Semperlotti, Fabio

2018-06-01

We investigate a generalized tomographic imaging framework applicable to a class of inhomogeneous media characterized by non-local diffusive energy transport. Under these conditions, the transport mechanism is well described by fractional-order continuum models capable of capturing anomalous diffusion that would otherwise remain undetected when using traditional integer-order models. Although the underlying idea of the proposed framework is applicable to any transport mechanism, the case of fractional heat conduction is presented as a specific example to illustrate the methodology. By using numerical simulations, we show how complex inhomogeneous media involving non-local transport can be successfully imaged if fractional order models are used. In particular, results will show that by properly recognizing and accounting for the fractional character of the host medium not only allows achieving increased resolution but, in case of strong and spatially distributed non-locality, it represents the only viable approach to achieve a successful reconstruction.

Scavenging and recombination kinetics in a radiation spur: The successive ordered scavenging events

NASA Astrophysics Data System (ADS)

Al-Samra, Eyad H.; Green, Nicholas J. B.

2018-03-01

This study describes stochastic models to investigate the successive ordered scavenging events in a spur of four radicals, a model system based on a radiation spur. Three simulation models have been developed to obtain the probabilities of the ordered scavenging events: (i) a Monte Carlo random flight (RF) model, (ii) hybrid simulations in which the reaction rate coefficient is used to generate scavenging times for the radicals and (iii) the independent reaction times (IRT) method. The results of these simulations are found to be in agreement with one another. In addition, a detailed master equation treatment is also presented, and used to extract simulated rate coefficients of the ordered scavenging reactions from the RF simulations. These rate coefficients are transient, the rate coefficients obtained for subsequent reactions are effectively equal, and in reasonable agreement with the simple correction for competition effects that has recently been proposed.

A Framework for Modeling Emerging Diseases to Inform Management.

PubMed

Russell, Robin E; Katz, Rachel A; Richgels, Katherine L D; Walsh, Daniel P; Grant, Evan H C

2017-01-01

The rapid emergence and reemergence of zoonotic diseases requires the ability to rapidly evaluate and implement optimal management decisions. Actions to control or mitigate the effects of emerging pathogens are commonly delayed because of uncertainty in the estimates and the predicted outcomes of the control tactics. The development of models that describe the best-known information regarding the disease system at the early stages of disease emergence is an essential step for optimal decision-making. Models can predict the potential effects of the pathogen, provide guidance for assessing the likelihood of success of different proposed management actions, quantify the uncertainty surrounding the choice of the optimal decision, and highlight critical areas for immediate research. We demonstrate how to develop models that can be used as a part of a decision-making framework to determine the likelihood of success of different management actions given current knowledge.

A framework for modeling emerging diseases to inform management

USGS Publications Warehouse

Russell, Robin E.; Katz, Rachel A.; Richgels, Katherine L. D.; Walsh, Daniel P.; Grant, Evan H. Campbell

2017-01-01

The rapid emergence and reemergence of zoonotic diseases requires the ability to rapidly evaluate and implement optimal management decisions. Actions to control or mitigate the effects of emerging pathogens are commonly delayed because of uncertainty in the estimates and the predicted outcomes of the control tactics. The development of models that describe the best-known information regarding the disease system at the early stages of disease emergence is an essential step for optimal decision-making. Models can predict the potential effects of the pathogen, provide guidance for assessing the likelihood of success of different proposed management actions, quantify the uncertainty surrounding the choice of the optimal decision, and highlight critical areas for immediate research. We demonstrate how to develop models that can be used as a part of a decision-making framework to determine the likelihood of success of different management actions given current knowledge.

Inclusiveness, Power Sharing and Critical Enquiry: Intercultural Programme Model for New Settlers

ERIC Educational Resources Information Center

Hayward, Maria; U-Mackey, Alice

2013-01-01

Migrants and refugees settling permanently in a new country face significant social, linguistic and cultural challenges. However, they also bring intercultural strengths and skills which, if acknowledged and enhanced, can support successful settlement and inclusion in a pluralistic society. This paper describes the underpinning rationale and…

Promoting Tech Schools within Your Community

ERIC Educational Resources Information Center

Nikirk, Martin

2010-01-01

This article describes a number of promotional events and practices that the author's school engages in. The author hopes that his school's experiences will serve as an inspiration and useful model for other "Tech Directions" readers. There are many methods for successfully promoting one's tech program. Two key strategies are: (1) Connect in…

Services for Men Who Batter: Implications for Programs and Policies.

ERIC Educational Resources Information Center

Feazell, Carann Simpson; And Others

1984-01-01

Analyzed data on services offered to battering males in a survey of 90 agencies. Found that most agencies are young, inadequately funded, and provide diverse services independent of each other, and that batterers exhibit characteristics that need specific treatment. Described a developing model for successful treatment. (JAC)

Wireless Computing in the Library: A Successful Model at St. Louis Community College.

ERIC Educational Resources Information Center

Patton, Janice K.

2001-01-01

Describes the St. Louis Community College (Missouri) library's use of laptop computers in the instruction lab as a way to save space and wiring costs. Discusses the pros and cons of wireless library instruction-advantages include its flexibility and its ability to eliminate cabling. (NB)

Storytelling: An Important Component of Successful Training.

ERIC Educational Resources Information Center

Siegel, Mark

1996-01-01

The director of production at Interactive Media Communications discusses its multimedia training models that address health and safety issues. Their purpose is to create entertaining instructional designs to guide the student in an interactive approach. The article describes two CD-ROM products (on hazardous chemicals and safe driving),…

Simulating dispersal of reintroduced species within heterogeneous landscapes

Treesearch

Robert H. Gardner; Eric J. Gustafson

2004-01-01

This paper describes the development and application of a spatially explicit, individual based model of animal dispersal (J-walk) to determine the relative effects of landscape heterogeneity, prey availability, predation risk, and the energy requirements and behavior of dispersing organisms on dispersal success. Significant unknowns exist for the simulation of complex...

Evaluating the Effectiveness of Reference Models in Federating Enterprise Architectures

ERIC Educational Resources Information Center

Wilson, Jeffery A.

2012-01-01

Agencies need to collaborate with each other to perform missions, improve mission performance, and find efficiencies. The ability of individual government agencies to collaborate with each other for mission and business success and efficiency is complicated by the different techniques used to describe their Enterprise Architectures (EAs).…

[Cognitive-behaviour therapy of schizophrenia].

PubMed

Keegan, Eduardo; Garay, Cristian Javier

2007-01-01

Cognitive-behaviour therapy is one of the evidence-based psychotherapies that have been successfully applied to the treatment of patients with psychotic symptoms. The article presents the core principles and objectives of cognitive models and interventions, and describes the generic steps of treatment. The results of the most methodologically-sound outcome studies are presented.

Partner Teaching: A Promising Model

ERIC Educational Resources Information Center

Bronson, Carroll E.; Dentith, Audrey M.

2014-01-01

This paper describes an ethnographic case study of a partner or co-teaching classroom in an urban preschool classroom. As part of a larger project that evaluated classroom size and team teaching structures in Kindergarten classrooms in several high poverty urban schools, one successful co-teaching classroom was studied further. Systematic…

A Collaborative Professional Development Initiative Supporting Early Literacy Coaches

ERIC Educational Resources Information Center

Mraz, Maryann; Kissel, Brian; Algozzine, Bob; Babb, Julie; Foxworth, Kimberly

2011-01-01

Many believe that the key to translating research into successful practice lies in providing teachers with continuous professional development and ongoing coaching support. In this article, we provide an overview of the relevant coaching literature and describe 4 critical features of an evidence-based preschool literacy coaching model: the coach…

Development of a rectal sexually transmitted infection (STI) Model in Rhesus macaques using Chlamydia trachomatis serovars E and L2.

PubMed

Henning, Tara R; Morris, Monica; Ellis, Shanon; Kelley, Kristen; Phillips, Christi; Ritter, Jana; Jones, Tara; Nachamkin, Eli; Chen, Cheng Y; Hong, Jaeyoung; Kang, Joseph; Patton, Dorothy; McNicholl, Janet; Papp, John; Kersh, Ellen N

2017-10-01

Rectal STI coinfection models enhance the understanding of rectal HIV transmission risk factors. Rhesus macaques (n=9) were exposed to one of three rectal Chlamydia trachomatis (CT) challenges: C. trachomatis L 2 (CT-L 2 ); C. trachomatis serovar E (CT-E), followed by CT-L 2 ; or CT-E, treatment/clearance, then CT-L 2 . Infections were monitored by PCR. Weekly blood and rectal secretion/lavage samples were collected for cytokine analyzes and/or epithelial sloughing, occult, and overt blood determinations. Chlamydial infections were successfully established in each animal, with varying degrees of persistence. Mucosal IL-1beta was upregulated in animals consecutively infected with CT-E then CT-L 2 (P=.05). Epithelial sloughing was also significantly increased post-infection in this group (P=.0003). This study demonstrates successful rectal infection of rhesus macaques with CT-E and CT-L 2 and describes measures of assessing rectal inflammation and pathology. Different infection strategies yield varying inflammatory and pathologic outcomes, providing well-described models for future SIV/SHIV susceptibility studies. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Collaborative practice model between cardiologists and clinical pharmacists for management of patients with cardiovascular disease in an outpatient clinic.

PubMed

Ripley, Toni L; Adamson, Philip B; Hennebry, Thomas A; Van Tuyl, Joseph S; Harrison, Donald L; Rathbun, R Chris

2014-03-01

The increasing prevalence of cardiovascular disease (CVD) has prompted leading cardiovascular organizations to advocate utilization of a team approach to patient care that includes nonphysician providers. In spite of that, the American College of Cardiology reported that nonphysician providers are underutilized in the management of patients with CVD. A survey of cardiologists revealed that the underutilization is a result of lack of understanding of how best to involve nonphysician providers in the health care team. Clinical pharmacists are one category of nonphysician providers that have recognized effectiveness in managing patients with CVD. No example of a comprehensive model of collaboration between cardiologists and clinical pharmacists is described in the literature that could serve to close this gap in understanding. The objective of this report is to describe a model of cardiologist-clinical pharmacist collaboration in the longitudinal management of patients with CVD that has been successfully implemented in 2 diverse settings. The implementation, evolution, scope of practice, required pharmacist training, logistical elements needed for success, and implementation barriers are reviewed. A summary of the patients referred to the clinic are examined as well.

The role of population inertia in predicting the outcome of stage-structured biological invasions.

PubMed

Guiver, Chris; Dreiwi, Hanan; Filannino, Donna-Maria; Hodgson, Dave; Lloyd, Stephanie; Townley, Stuart

2015-07-01

Deterministic dynamic models for coupled resident and invader populations are considered with the purpose of finding quantities that are effective at predicting when the invasive population will become established asymptotically. A key feature of the models considered is the stage-structure, meaning that the populations are described by vectors of discrete developmental stage- or age-classes. The vector structure permits exotic transient behaviour-phenomena not encountered in scalar models. Analysis using a linear Lyapunov function demonstrates that for the class of population models considered, a large so-called population inertia is indicative of successful invasion. Population inertia is an indicator of transient growth or decline. Furthermore, for the class of models considered, we find that the so-called invasion exponent, an existing index used in models for invasion, is not always a reliable comparative indicator of successful invasion. We highlight these findings through numerical examples and a biological interpretation of why this might be the case is discussed. Copyright © 2015. Published by Elsevier Inc.

WhichP450: a multi-class categorical model to predict the major metabolising CYP450 isoform for a compound

NASA Astrophysics Data System (ADS)

Hunt, Peter A.; Segall, Matthew D.; Tyzack, Jonathan D.

2018-02-01

In the development of novel pharmaceuticals, the knowledge of how many, and which, Cytochrome P450 isoforms are involved in the phase I metabolism of a compound is important. Potential problems can arise if a compound is metabolised predominantly by a single isoform in terms of drug-drug interactions or genetic polymorphisms that would lead to variations in exposure in the general population. Combined with models of regioselectivities of metabolism by each isoform, such a model would also aid in the prediction of the metabolites likely to be formed by P450-mediated metabolism. We describe the generation of a multi-class random forest model to predict which, out of a list of the seven leading Cytochrome P450 isoforms, would be the major metabolising isoforms for a novel compound. The model has a 76% success rate with a top-1 criterion and an 88% success rate for a top-2 criterion and shows significant enrichment over randomised models.

Applications of amorphous track models in radiation biology

NASA Technical Reports Server (NTRS)

Cucinotta, F. A.; Nikjoo, H.; Goodhead, D. T.; Wilson, J. W. (Principal Investigator)

1999-01-01

The average or amorphous track model uses the response of a system to gamma-rays and the radial distribution of dose about an ion's path to describe survival and other cellular endpoints from proton, heavy ion, and neutron irradiation. This model has been used for over 30 years to successfully fit many radiobiology data sets. We review several extensions of this approach that address objections to the original model, and consider applications of interest in radiobiology and space radiation risk assessment. In the light of present views of important cellular targets, the role of target size as manifested through the relative contributions from ion-kill (intra-track) and gamma-kill (inter-track) remains a critical question in understanding the success of the amorphous track model. Several variations of the amorphous model are discussed, including ones that consider the radial distribution of event-sizes rather than average electron dose, damage clusters rather than multiple targets, and a role for repair or damage processing.

Modeling the relations between flow regime components, species traits, and spawning success of fishes in warmwater streams

USGS Publications Warehouse

Craven, S.W.; Peterson, J.T.; Freeman, Mary C.; Kwak, T.J.; Irwin, E.

2010-01-01

Modifications to stream hydrologic regimes can have a profound influence on the dynamics of their fish populations. Using hierarchical linear models, we examined the relations between flow regime and young-of-year fish density using fish sampling and discharge data from three different warmwater streams in Illinois, Alabama, and Georgia. We used an information theoretic approach to evaluate the relative support for models describing hypothesized influences of five flow regime components representing: short-term high and low flows; short-term flow stability; and long-term mean flows and flow stability on fish reproductive success during fish spawning and rearing periods. We also evaluated the influence of ten fish species traits on fish reproductive success. Species traits included spawning duration, reproductive strategy, egg incubation rate, swimming locomotion morphology, general habitat preference, and food habits. Model selection results indicated that young-of-year fish density was positively related to short-term high flows during the spawning period and negatively related to flow variability during the rearing period. However, the effect of the flow regime components varied substantially among species, but was related to species traits. The effect of short-term high flows on the reproductive success was lower for species that broadcast their eggs during spawning. Species with cruiser swimming locomotion morphologies (e.g., Micropterus) also were more vulnerable to variable flows during the rearing period. Our models provide insight into the conditions and timing of flows that influence the reproductive success of warmwater stream fishes and may guide decisions related to stream regulation and management. ?? 2010 US Government.

Model of anisotropic nonlinearity in self-defocusing photorefractive media.

PubMed

Barsi, C; Fleischer, J W

2015-09-21

We develop a phenomenological model of anisotropy in self-defocusing photorefractive crystals. In addition to an independent term due to nonlinear susceptibility, we introduce a nonlinear, non-separable correction to the spectral diffraction operator. The model successfully describes the crossover between photovoltaic and photorefractive responses and the spatially dispersive shock wave behavior of a nonlinearly spreading Gaussian input beam. It should prove useful for characterizing internal charge dynamics in complex materials and for accurate image reconstruction through nonlinear media.

Studies of radar backscatter as a function of wave properties and the winds in the turbulent marine atmosphere

NASA Technical Reports Server (NTRS)

Pierson, Willard J., Jr.; Sylvester, Winfield B.

1995-01-01

The research on model functions for ADEOS and ERS-1 are summarized and an analysis of the differences between the three kinds of models is provided in this final report. The success of the AMI on ERS-1 obtained at GSFC and NMC is highlighted. The problem of wind stress description is reviewed within and the scatterometer model being developed for high winds monitoring for the AMI on ERS-1 and ERS-2 is described.

Behavioral studies on anxiety and depression in a drug discovery environment: keys to a successful future.

PubMed

Bouwknecht, J Adriaan

2015-04-15

The review describes a personal journey through 25 years of animal research with a focus on the contribution of rodent models for anxiety and depression to the development of new medicines in a drug discovery environment. Several classic acute models for mood disorders are briefly described as well as chronic stress and disease-induction models. The paper highlights a variety of factors that influence the quality and consistency of behavioral data in a laboratory setting. The importance of meta-analysis techniques for study validation (tolerance interval) and assay sensitivity (Monte Carlo modeling) are demonstrated by examples that use historic data. It is essential for successful discovery of new potential drugs to maintain a high level of control in animal research and to bridge knowledge across in silico modeling, and in vitro and in vivo assays. Today, drug discovery is a highly dynamic environment in search of new types of treatments and new animal models which should be guided by enhanced two-way translation between bench and bed. Although productivity has been disappointing in the search of new and better medicines in psychiatry over the past decades, there has been and will always be an important role for in vivo models in-between preclinical discovery and clinical development. The right balance between good science and proper judgment versus a decent level of innovation, assay development and two-way translation will open the doors to a very bright future. Copyright © 2014 Elsevier B.V. All rights reserved.

Dynamics Simulation Model for Space Tethers

NASA Technical Reports Server (NTRS)

Levin, E. M.; Pearson, J.; Oldson, J. C.

2006-01-01

This document describes the development of an accurate model for the dynamics of the Momentum Exchange Electrodynamic Reboost (MXER) system. The MXER is a rotating tether about 100-km long in elliptical Earth orbit designed to catch payloads in low Earth orbit and throw them to geosynchronous orbit or to Earth escape. To ensure successful rendezvous between the MXER tip catcher and a payload, a high-fidelity model of the system dynamics is required. The model developed here quantifies the major environmental perturbations, and can predict the MXER tip position to within meters over one orbit.

On solitons: the biomolecular nonlinear transmission line models with constant and time variable coefficients

NASA Astrophysics Data System (ADS)

Raza, Nauman; Murtaza, Isma Ghulam; Sial, Sultan; Younis, Muhammad

2018-07-01

The article studies the dynamics of solitons in electrical microtubule ? model, which describes the propagation of waves in nonlinear dynamical system. Microtubules are not only a passive support of a cell but also they have highly dynamic structures involved in cell motility, intracellular transport and signaling. The underlying model has been considered with constant and variable coefficients of time function. The solitary wave ansatz has been applied successfully to extract these solitons. The corresponding integrability criteria, also known as constraint conditions, naturally emerge from the analysis of these models.

Building Information Model: advantages, tools and adoption efficiency

NASA Astrophysics Data System (ADS)

Abakumov, R. G.; Naumov, A. E.

2018-03-01

The paper expands definition and essence of Building Information Modeling. It describes content and effects from application of Information Modeling at different stages of a real property item. Analysis of long-term and short-term advantages is given. The authors included an analytical review of Revit software package in comparison with Autodesk with respect to: features, advantages and disadvantages, cost and pay cutoff. A prognostic calculation is given for efficiency of adoption of the Building Information Modeling technology, with examples of its successful adoption in Russia and worldwide.

The Big Bang and Cosmic Inflation

NASA Astrophysics Data System (ADS)

Guth, Alan H.

2014-03-01

A summary is given of the key developments of cosmology in the 20th century, from the work of Albert Einstein to the emergence of the generally accepted hot big bang model. The successes of this model are reviewed, but emphasis is placed on the questions that the model leaves unanswered. The remainder of the paper describes the inflationary universe model, which provides plausible answers to a number of these questions. It also offers a possible explanation for the origin of essentially all the matter and energy in the observed universe.

Hydrodynamic Aspects of Particle Clogging in Porous Media

PubMed Central

MAYS, DAVID C.; HUNT, JAMES R.

2010-01-01

Data from 6 filtration studies, representing 43 experiments, are analyzed with a simplified version of the single-parameter O’Melia and Ali clogging model. The model parameter displays a systematic dependence on fluid velocity, which was an independent variable in each study. A cake filtration model also explains the data from one filtration study by varying a single, velocity-dependent parameter, highlighting that clogging models, because they are empirical, are not unique. Limited experimental data indicate exponential depth dependence of particle accumulation, whose impact on clogging is quantified with an extended O’Melia and Ali model. The resulting two-parameter model successfully describes the increased clogging that is always observed in the top segment of a filter. However, even after accounting for particle penetration, the two-parameter model suggests that a velocity-dependent parameter representing deposit morphology must also be included to explain the data. Most of the experimental data are described by the single-parameter O’Melia and Ali model, and the model parameter is correlated to the collector Peclet number. PMID:15707058

Organizational transformation to improve operational efficiency at Gemini South

NASA Astrophysics Data System (ADS)

van der Hoeven, M.; Maltes, Diego; Rogers, Rolando

2016-07-01

In this paper we will describe how the Gemini South Engineering team has been reorganized from different functional units into a cross-disciplinary team while executing a transition plan that imposes several staff reductions, driven by budget reductions. Several factors are of critical importance to the success of any change in organization. Budgetary processes, staff diversity, leadership style, skill sets and planning are all important factors to take into account to achieve a successful outcome. We will analyze the organizational alignment by using some proven management models and concepts.

A data driven nonlinear stochastic model for blood glucose dynamics.

PubMed

Zhang, Yan; Holt, Tim A; Khovanova, Natalia

2016-03-01

The development of adequate mathematical models for blood glucose dynamics may improve early diagnosis and control of diabetes mellitus (DM). We have developed a stochastic nonlinear second order differential equation to describe the response of blood glucose concentration to food intake using continuous glucose monitoring (CGM) data. A variational Bayesian learning scheme was applied to define the number and values of the system's parameters by iterative optimisation of free energy. The model has the minimal order and number of parameters to successfully describe blood glucose dynamics in people with and without DM. The model accounts for the nonlinearity and stochasticity of the underlying glucose-insulin dynamic process. Being data-driven, it takes full advantage of available CGM data and, at the same time, reflects the intrinsic characteristics of the glucose-insulin system without detailed knowledge of the physiological mechanisms. We have shown that the dynamics of some postprandial blood glucose excursions can be described by a reduced (linear) model, previously seen in the literature. A comprehensive analysis demonstrates that deterministic system parameters belong to different ranges for diabetes and controls. Implications for clinical practice are discussed. This is the first study introducing a continuous data-driven nonlinear stochastic model capable of describing both DM and non-DM profiles. Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Process-driven selection of information systems for healthcare

NASA Astrophysics Data System (ADS)

Mills, Stephen F.; Yeh, Raymond T.; Giroir, Brett P.; Tanik, Murat M.

1995-05-01

Integration of networking and data management technologies such as PACS, RIS and HIS into a healthcare enterprise in a clinically acceptable manner is a difficult problem. Data within such a facility are generally managed via a combination of manual hardcopy systems and proprietary, special-purpose data processing systems. Process modeling techniques have been successfully applied to engineering and manufacturing enterprises, but have not generally been applied to service-based enterprises such as healthcare facilities. The use of process modeling techniques can provide guidance for the placement, configuration and usage of PACS and other informatics technologies within the healthcare enterprise, and thus improve the quality of healthcare. Initial process modeling activities conducted within the Pediatric ICU at Children's Medical Center in Dallas, Texas are described. The ongoing development of a full enterprise- level model for the Pediatric ICU is also described.

An application of the transtheoretical model to becoming vegan.

PubMed

Mendes, Elisabeth

2013-01-01

This article applies the transtheoretical model TM to veganism. By and large, the TM is a model of behavioral change that incorporates different stages to describe how an individual moves from an unhealthy behavior to a healthy one. The TM construes change as a five-stage process. The five stages of change are (a) precontemplation, (b) contemplation, (c) preparation, (d) action, and (e) maintenance. In this analysis, the model is applied to a person's determination to become vegan. A person chooses to become a vegan by eliminating all animal products from his or her diets; he or she does this by progressing through the stages, as prescribed by the model. The different changes people make to their life are described in detail. It is also possible to measure the success of a person's progression based on positive health changes that he or she experiences.

Dementia service centres in Austria: A comprehensive support and early detection model for persons with dementia and their caregivers – theoretical foundations and model description

PubMed Central

Span, Edith; Reisberg, Barry

2015-01-01

Despite the highly developed social services in Austria, the County of Upper Austria, one of the nine counties of Austria had only very limited specialized services for persons with dementia and their caregivers in 2001. Support groups existed in which the desire for more specialized services was voiced. In response to this situation, funding was received to develop a new structure for early disease detection and long term support for both the person with dementia and their caregivers. This article describes the development of the model of the Dementia Service Centres (DSCs) and the successes and difficulties encountered in the process of implementing the model in six different rural regions of Upper Austria. The DSC was described in the First Austrian Dementia Report as one of the potential service models for the future. PMID:24339114

Dementia service centres in Austria: A comprehensive support and early detection model for persons with dementia and their caregivers - theoretical foundations and model description.

PubMed

Auer, Stefanie R; Span, Edith; Reisberg, Barry

2015-07-01

Despite the highly developed social services in Austria, the County of Upper Austria, one of the nine counties of Austria had only very limited specialized services for persons with dementia and their caregivers in 2001. Support groups existed in which the desire for more specialized services was voiced. In response to this situation, funding was received to develop a new structure for early disease detection and long term support for both the person with dementia and their caregivers. This article describes the development of the model of the Dementia Service Centres (DSCs) and the successes and difficulties encountered in the process of implementing the model in six different rural regions of Upper Austria. The DSC was described in the First Austrian Dementia Report as one of the potential service models for the future. © The Author(s) 2013.

An extended car-following model to describe connected traffic dynamics under cyberattacks

NASA Astrophysics Data System (ADS)

Wang, Pengcheng; Yu, Guizhen; Wu, Xinkai; Qin, Hongmao; Wang, Yunpeng

2018-04-01

In this paper, the impacts of the potential cyberattacks on vehicles are modeled through an extended car-following model. To better understand the mechanism of traffic disturbance under cyberattacks, the linear and nonlinear stability analysis are conducted respectively. Particularly, linear stability analysis is performed to obtain different neutral stability conditions with various parameters; and nonlinear stability analysis is carried out by using reductive perturbation method to derive the soliton solution of the modified Korteweg de Vries equation (mKdV) near the critical point, which is used to draw coexisting stability lines. Furthermore, by applying linear and nonlinear stability analysis, traffic flow state can be divided into three states, i.e., stable, metastable and unstable states which are useful to describe shockwave dynamics and driving behaviors under cyberattacks. The theoretical results show that the proposed car-following model is capable of successfully describing the car-following behavior of connected vehicles with cyberattacks. Finally, numerical simulation using real values has confirmed the validity of theoretical analysis. The results further demonstrate our model can be used to help avoid collisions and relieve traffic congestion with cybersecurity threats.

An investigation of modelling and design for software service applications

PubMed Central

2017-01-01

Software services offer the opportunity to use a component-based approach for the design of applications. However, this needs a deeper understanding of how to develop service-based applications in a systematic manner, and of the set of properties that need to be included in the ‘design model’. We have used a realistic application to explore systematically how service-based designs can be created and described. We first identified the key properties of an SOA (service oriented architecture) and then undertook a single-case case study to explore its use in the development of a design for a large-scale application in energy engineering, modelling this with existing notations wherever possible. We evaluated the resulting design model using two walkthroughs with both domain and application experts. We were able to successfully develop a design model around the ten properties identified, and to describe it by adapting existing design notations. A component-based approach to designing such systems does appear to be feasible. However, it needs the assistance of a more integrated set of notations for describing the resulting design model. PMID:28489905

Interaction of cadmium with phosphate on goethite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Venema, P.; Hiemstra, T.; Riemsdijk, W.H. van

1997-08-01

Interactions between different ions are of importance in understanding chemical processes in natural systems. In this study simultaneous adsorption of phosphate and cadmium on goethite is studied in detail. The charge distribution (CD)-multisite complexation (MUSIC) model has been successful in describing extended data sets of cadmium adsorption and phosphate adsorption on goethite. In this study, the parameters of this model for these two data sets were combined to describe a new data set of simultaneous adsorption of cadmium and phosphate on goethite. Attention is focused on the surface speciation of cadmium. With the extra information that can be obtained frommore » the interaction experiments, the cadmium adsorption model is refined. For a perfect description of the data, the singly coordinated surface groups at the 110 face of goethite were assumed to form both monodentate and bidentate surface species with cadmium. The CD-MUSIC model is able to describe data sets of both simultaneous and single adsorption of cadmium and phosphate with the same parameters. The model calculations confirmed the idea that only singly coordinated surface groups are reactive for specific ion binding.« less

Spatio-temporal modelling of wind speed variations and extremes in the Caribbean and the Gulf of Mexico

NASA Astrophysics Data System (ADS)

Rychlik, Igor; Mao, Wengang

2018-02-01

The wind speed variability in the North Atlantic has been successfully modelled using a spatio-temporal transformed Gaussian field. However, this type of model does not correctly describe the extreme wind speeds attributed to tropical storms and hurricanes. In this study, the transformed Gaussian model is further developed to include the occurrence of severe storms. In this new model, random components are added to the transformed Gaussian field to model rare events with extreme wind speeds. The resulting random field is locally stationary and homogeneous. The localized dependence structure is described by time- and space-dependent parameters. The parameters have a natural physical interpretation. To exemplify its application, the model is fitted to the ECMWF ERA-Interim reanalysis data set. The model is applied to compute long-term wind speed distributions and return values, e.g., 100- or 1000-year extreme wind speeds, and to simulate random wind speed time series at a fixed location or spatio-temporal wind fields around that location.

Discrete dynamic modeling of cellular signaling networks.

PubMed

Albert, Réka; Wang, Rui-Sheng

2009-01-01

Understanding signal transduction in cellular systems is a central issue in systems biology. Numerous experiments from different laboratories generate an abundance of individual components and causal interactions mediating environmental and developmental signals. However, for many signal transduction systems there is insufficient information on the overall structure and the molecular mechanisms involved in the signaling network. Moreover, lack of kinetic and temporal information makes it difficult to construct quantitative models of signal transduction pathways. Discrete dynamic modeling, combined with network analysis, provides an effective way to integrate fragmentary knowledge of regulatory interactions into a predictive mathematical model which is able to describe the time evolution of the system without the requirement for kinetic parameters. This chapter introduces the fundamental concepts of discrete dynamic modeling, particularly focusing on Boolean dynamic models. We describe this method step-by-step in the context of cellular signaling networks. Several variants of Boolean dynamic models including threshold Boolean networks and piecewise linear systems are also covered, followed by two examples of successful application of discrete dynamic modeling in cell biology.

A new approach to design and use of management information.

PubMed

Daft, R L; MacIntosh, N B

1978-01-01

Information, that is both accurate and timely, is probably the most important resource needed by managers to make sound decisions regarding the problems and issues facing their organizations. Unfortunately, sophisticated information systems often fail to meet this need. Managers complain that the data produced by information systems arrive too late, are too general and lack accuracy. Daft and MacIntosh studied the system problems of a number of organizations, discovering that understanding their work activities is critical to the design of successful information systems. The authors also considered the volume of information, preciseness of information and the way in which it is handled by users to develop a model describing information systems. The article illustrates how the model was applied successfully to four case situations.

Experimental comparison of residual stresses for a thermomechanical model for the simulation of selective laser melting

DOE PAGES

Hodge, N. E.; Ferencz, R. M.; Vignes, R. M.

2016-05-30

Selective laser melting (SLM) is an additive manufacturing process in which multiple, successive layers of metal powders are heated via laser in order to build a part. Modeling of SLM requires consideration of the complex interaction between heat transfer and solid mechanics. Here, the present work describes the authors initial efforts to validate their first generation model. In particular, the comparison of model-generated solid mechanics results, including both deformation and stresses, is presented. Additionally, results of various perturbations of the process parameters and modeling strategies are discussed.

A complete dynamic model of primary sedimentation.

PubMed

Paraskevas, P; Kolokithas, G; Lekkas, T

1993-11-01

A dynamic mathematical model for the primary clarifier of a wastewater treatment plant is described, which is represented by a general tanks-in-series model, to simulate insufficient mixing. The model quantifies successfully the diurnal response of both the suspended and dissolved species. It is general enough, so that the values of the parameters can be replaced with those applicable to a specific case. The model was verified through data from the Biological Centre of Metamorfosi, in Athens, Greece, and can be used to assist in the design of new plants or in the analysis and output predictions of existing ones.

Convection-Enhanced Delivery (CED) in an Animal Model of Malignant Peripheral Nerve Sheath Tumors and Plexiform Neurofibromas

DTIC Science & Technology

2013-02-01

successfully establish the xenograft within the sciatic nerve. Convection-Enhanced Delivery ( CED ), Malignant Peripheral Nerve Sheath ( MPNST ), Plexiform...intraneural PNs and MPNST via CED . Design: Orthotopic xenograft models of sciatic intraneural NF1 MPNST and PNs in scid mice as described by Perrin et...using convection-enhanced delivery ( CED ). Relative Growth of MPNST cells in vivo treated with rapamycin, imatinib or erlotinib: Elotinib

The Next Step Toward Widespread Residential Deep Energy Retrofits

DOE Office of Scientific and Technical Information (OSTI.GOV)

McIlvaine, J.; Martin, E.; Saunders, S.

The complexity of deep energy retrofits warrants additional training to successfully manage multiple improvements that will change whole house air, heat, and moisture flow dynamics. The home performance contracting industry has responded to these challenges by aggregating skilled labor for assessment of and implementation under one umbrella. Two emerging business models are profiled that seek to resolve many of the challenges, weaknesses, opportunities, and threats described for the conventional business models.

Building and Verifying a Predictive Model of Interruption Resumption

DTIC Science & Technology

2012-03-01

field, the vocal module speaks, the motor module moves the body, and the con- figural and manipulative modules perform spatial proces- sing [14]–[16...person cannot remember themselves. As described earlier, the model depends critically upon the basic properties of declarative memories. When a...success because the model’s ability to re- trieve an episodic code depends critically on the amount of time spent on the interruption. Also recall that

Lessons Learned from the Implementation of Brighter Bites: A Food Co-Op to Increase Access to Fruits and Vegetables and Nutrition Education among Low-income Children and Their Families

ERIC Educational Resources Information Center

Sharma, Shreela V.; Chow, Joanne; Pomeroy, Michael; Raber, Margaret; Salako, David; Markham, Christine

2017-01-01

Background: Food co-op models have gained popularity as a mechanism for offering affordable, quality produce. We describe the challenges, successes, and lessons learned from implementation of a school-based program using a food co-op model combined with nutrition education to improve access to and intake of fresh fruits and vegetables among…

Primary care ... where?

PubMed

Adcock, G B

1999-07-01

Corporate-based nurse managed centers are not the national norm. More prevalent is the use of an occupational health or physician-directed medical model of care. The author describes how a 14-year-old primary care center at a North Carolina computer software company is just "business as usual" when viewed in the context of the company's philosophy, goals, and culture. Included are considerations for nurse practitioners interested in the successful transplantation of this primary care model to other settings.

A network model of successive partitioning-limited solute diffusion through the stratum corneum.

PubMed

Schumm, Phillip; Scoglio, Caterina M; van der Merwe, Deon

2010-02-07

As the most exposed point of contact with the external environment, the skin is an important barrier to many chemical exposures, including medications, potentially toxic chemicals and cosmetics. Traditional dermal absorption models treat the stratum corneum lipids as a homogenous medium through which solutes diffuse according to Fick's first law of diffusion. This approach does not explain non-linear absorption and irregular distribution patterns within the stratum corneum lipids as observed in experimental data. A network model, based on successive partitioning-limited solute diffusion through the stratum corneum, where the lipid structure is represented by a large, sparse, and regular network where nodes have variable characteristics, offers an alternative, efficient, and flexible approach to dermal absorption modeling that simulates non-linear absorption data patterns. Four model versions are presented: two linear models, which have unlimited node capacities, and two non-linear models, which have limited node capacities. The non-linear model outputs produce absorption to dose relationships that can be best characterized quantitatively by using power equations, similar to the equations used to describe non-linear experimental data.

Operational Experience of an Open-Access, Subscription-Based Mass Spectrometry and Proteomics Facility.

PubMed

Williamson, Nicholas A

2018-03-01

This paper discusses the successful adoption of a subscription-based, open-access model of service delivery for a mass spectrometry and proteomics facility. In 2009, the Mass Spectrometry and Proteomics Facility at the University of Melbourne (Australia) moved away from the standard fee for service model of service provision. Instead, the facility adopted a subscription- or membership-based, open-access model of service delivery. For a low fixed yearly cost, users could directly operate the instrumentation but, more importantly, there were no limits on usage other than the necessity to share available instrument time with all other users. All necessary training from platform staff and many of the base reagents were also provided as part of the membership cost. These changes proved to be very successful in terms of financial outcomes for the facility, instrument access and usage, and overall research output. This article describes the systems put in place as well as the overall successes and challenges associated with the operation of a mass spectrometry/proteomics core in this manner. Graphical abstract ᅟ.

Operational Experience of an Open-Access, Subscription-Based Mass Spectrometry and Proteomics Facility

NASA Astrophysics Data System (ADS)

Williamson, Nicholas A.

2018-03-01

This paper discusses the successful adoption of a subscription-based, open-access model of service delivery for a mass spectrometry and proteomics facility. In 2009, the Mass Spectrometry and Proteomics Facility at the University of Melbourne (Australia) moved away from the standard fee for service model of service provision. Instead, the facility adopted a subscription- or membership-based, open-access model of service delivery. For a low fixed yearly cost, users could directly operate the instrumentation but, more importantly, there were no limits on usage other than the necessity to share available instrument time with all other users. All necessary training from platform staff and many of the base reagents were also provided as part of the membership cost. These changes proved to be very successful in terms of financial outcomes for the facility, instrument access and usage, and overall research output. This article describes the systems put in place as well as the overall successes and challenges associated with the operation of a mass spectrometry/proteomics core in this manner. [Figure not available: see fulltext.

Presentation-order effects for aesthetic stimulus preference.

PubMed

Englund, Mats P; Hellström, Åke

2012-10-01

For preference comparisons of paired successive musical excerpts, Koh (American Journal of Psychology, 80, 171-185, 1967) found time-order effects (TOEs) that correlated negatively with stimulus valence-the first (vs. the second) of two unpleasant (vs. two pleasant) excerpts tended to be preferred. We present three experiments designed to investigate whether valence-level-dependent order effects for aesthetic preference (a) can be accounted for using Hellström's (e.g., Journal of Experimental Psychology: Human Perception and Performance, 5, 460-477, 1979) sensation-weighting (SW) model, (b) can be generalized to successive and to simultaneous visual stimuli, and (c) vary, in accordance with the stimulus weighting, with interstimulus interval (ISI; for successive stimuli) or stimulus duration (for simultaneous stimuli). Participants compared paired successive jingles (Exp. 1), successive color patterns (Exp. 2), and simultaneous color patterns (Exp. 3), selecting the preferred stimulus. The results were well described by the SW model, which provided a better fit than did two extended versions of the Bradley-Terry-Luce model. Experiments 1 and 2 revealed higher weights for the second stimulus than for the first, and negatively valence-level-dependent TOEs. In Experiment 3, there was no laterality effect on the stimulus weighting and no valence-level-dependent space-order effects (SOEs). In terms of the SW model, the valence-level-dependent TOEs can be explained as a consequence of differential stimulus weighting in combination with stimulus valence varying from low to high, and the absence of valence-level-dependent SOEs as a consequence of the absence of differential weighting. For successive stimuli, there were no important effects of ISI on weightings and TOEs, and, for simultaneous stimuli, duration had only a small effect on the weighting.

A Strategic Model to Address Issues of Student Achievement

ERIC Educational Resources Information Center

Fontana, Leonard; Johnson, Elease; Green, Peggy; Macia, Jose; Wright, Ted; Daniel, Yanick; Distefano Diaz, Mary F.; Obenauf, Steve

2006-01-01

This article describes an interactive and collaborative strategic planning process by a community college in which student retention and success became a focus of a re-accreditation endeavor. The underlying assumption of this strategic planning effort was that engaging all groups that have a stake in student retention at the beginning of the…

Ideotype Development in Southern Pines: Rationale and Strategies for Overcoming Scale-Related Obstacles

Treesearch

Timothy A. Martin; Kurt H. Johnsen; Timothy L. White

2001-01-01

Indirect genetic selection for early growth and disease resistance of southern pines has proven remarkably successful over the past several decades. However, several benefits could be derived for southern pine breeding programs by incorporating ideotypes, conceptual models which explicitly describe plant phenotypic characteristics that are hypothesized to produce...

A Grass-Roots Endeavor To Develop a Permanent University Program for Vision Professionals: The North Carolina Model.

ERIC Educational Resources Information Center

Walker, Brad R.; Bozeman, Laura A.

2002-01-01

This article describes a collaborative process that parents, teachers, consumers, and advocacy groups in North Carolina used to successfully establish a permanently funded university training program specializing in visual impairments, the Visual Impairment Training Program. Within this process several factors were identified that contributed to…

Grant Proposal Development a la FLC (Faculty Learning Community) Mode

ERIC Educational Resources Information Center

Frantz, Pollyanne S.

2013-01-01

Although the Faculty Learning Community is not a new structure or initiative in the higher education arena, adapting this model for faculty development focused on grant proposal writing is relatively new. This article describes how the concept developed by Milt Cox of Miami University has been successfully modified and implemented twice on the…

Lesjes van de Nederlanders: Little Lessons from the Dutch to Promote Educational Quality.

ERIC Educational Resources Information Center

Palmer, Barbara H.

1996-01-01

A study explored quality assessment and accountability in Dutch university education. The national system of quality assurance and various models used successfully to implement it are described, and the range of apparent effects and influences of quality assurance on Dutch higher education are examined. Comparison is made with American higher…

Mothers with Severe Psychiatric Illness and Their Newborns: A Hospital-Based Model of Perinatal Consultation

ERIC Educational Resources Information Center

Almeida, Ana; Merminod, Gaelle, Schechter, Daniel S.

2009-01-01

Women with severe psychiatric illness face numerous risks and challenges during pregnancy and as parents. Mental health professionals can help these mothers and their infants by supporting the attachment relationship and by providing the external supports that are necessary for successful parenting. The authors describe a hospital-based…

Modeling Successful STEM High Schools in the United States: An Ecology Framework

ERIC Educational Resources Information Center

Erdogan, Niyazi; Stuessy, Carol L.

2015-01-01

This study aims to generate a conceptual framework for specialized Science, Technology, Engineering, and Mathematics (STEM) schools. To do so, we focused on literature and found specialized STEM schools have existed for over 100 years and recently expanded nationwide. The current perception for these schools can be described as unique environments…

An evidence-based model for enriching academic nursing leadership.

PubMed

Wolf, Gail A; Dunbar-Jacob, Jacqueline; Greenhouse, Pamela

2006-12-01

The challenge of developing contemporary nurse leaders for today and tomorrow is compounded not only by the faculty shortage but also by limited faculty expertise in healthcare administration. The authors describe an effective academic-service partnership designed to ground future nursing leaders in the knowledge, skills, and abilities essential for success.

Business/Education Partnerships in South Carolina. Model Projects.

ERIC Educational Resources Information Center

South Carolina State Dept. of Education, Columbia. Div. of Public Accountability.

This document contains reports from school districts in South Carolina on the status of their successful partnerships between schools and businesses. They are examples of what is happening in South Carolina today and what could happen between other businesses and schools as new alliances are formed. These accounts describe new ideas for…

Creating a Model for Graduate Student Inclusion and Success

ERIC Educational Resources Information Center

Duranczyk, Irene M.; Franko, Jennifer; Osifuye, Shade'; Barton, Amy; Higbee, Jeanne L.

2015-01-01

Mentoring and advising are critical aspects of the graduate student experience, and can have a significant impact on the professional lives of future postsecondary faculty and staff and a rippling effect throughout higher education and the global economy. This paper describes the process a new department undertook to create a graduate program that…

Suggestions for Implementing First Year Experience Learning Communities in Teacher Education Programs

ERIC Educational Resources Information Center

Hintz, Kathryn; Genareo, Vincent

2017-01-01

This article describes the creation of a First Year Experience learning community in a teacher education program. The First Year Experience model was adopted by the university because of declining enrollment, retention, and graduation rates and has been generally successful in the education department. With little information available for teacher…

Methods and Case Studies for Teaching and Learning about Failure and Safety.

ERIC Educational Resources Information Center

Bignell, Victor

1999-01-01

Discusses methods for analyzing case studies of failures of technological systems. Describes two distance learning courses that compare standard models of failure and success with the actuality of given scenarios. Provides teaching and learning materials and information sources for application to aspects of design, manufacture, inspection, use,…

Effective Live Online Faculty Development Workshops: One Model

ERIC Educational Resources Information Center

Blyth, Russell D.; May, Michael K.; Rainbolt, Julianne G.

2006-01-01

This article describes live, online faculty development workshops that show faculty how to use software packages (to date, GAP and Maple) in teaching college-level mathematics. The authors' primary goal in this article is to encourage others in any discipline to run similar online workshops by providing a resource for their successful operation,…

Linking mechanistic toxicology to population models in forecasting recovery from chemical stress: A case study from Jackfish Bay, Ontario, Canada

EPA Science Inventory

A Beneficial Use Impairment (BUI) common at Great Lakes Areas of Concern (AOCs) is loss of fish and wildlife populations. Consequently, recovery of populations after stressor mitigation serves as a basis for evaluating remediation success. We describe a framework that can be a...

The multiple resource inventory decision-making process

Treesearch

Victor A. Rudis

1993-01-01

A model of the multiple resource inventory decision-making process is presented that identifies steps in conducting inventories, describes the infrastructure, and points out knowledge gaps that are common to many interdisciplinary studies.Successful efforts to date suggest the need to bridge the gaps by sharing elements, maintain dialogue among stakeholders in multiple...

The Community Grant Writing Project: A Flexible Service-Learning Model for Writing-Intensive Courses

ERIC Educational Resources Information Center

Stevens, Courtney

2014-01-01

This article describes the Community Grant Writing Project (CGWP), a flexible service-learning framework designed for use in writing-intensive courses. The CGWP incorporates best-practice recommendations from the service-learning literature and addresses recent challenges identified for successful service-learning partnerships. In the CGWP,…

International Futures (IFs): A Global Issues Simulation for Teaching and Research.

ERIC Educational Resources Information Center

Hughes, Barry B.

This paper describes the International Futures (IFs) computer assisted simulation game for use with undergraduates. Written in Standard Fortran IV, the model currently runs on mainframe or mini computers, but has not been adapted for micros. It has been successfully installed on Harris, Burroughs, Telefunken, CDC, Univac, IBM, and Prime machines.…

Home Visiting for At-Risk Preschoolers: A Successful Model for Latino Families

ERIC Educational Resources Information Center

Nievar, M. Angela; Jacobson, A.; Dier, S.

2008-01-01

The Home Instruction for Parents of Preschool Youngsters (HIPPY) program promotes school readiness by providing services directly to parents through home visitation. This study describes the outcomes of the HIPPY program for Latino immigrant families in a large Southwestern city. A quasi-experimental design compared 48 families on the program…

Ten Project Areas to Stimulate an Interest in Reading.

ERIC Educational Resources Information Center

Leigh, Robert K.; And Others

The result of an International Reading Association committee organized to identify successful community programs that stimulate an interest in reading, this paper identifies and describes 10 selected program areas that might be used as models for other communities. Following a brief description of the project and the submission criteria, the 10…

District-Wide Involvement: The Key to Successful School Improvement.

ERIC Educational Resources Information Center

Mundell, Scott; Babich, George

1989-01-01

Describes the self-study process used by the Marana Unified School District to meet accreditation requirements with minimal expense, to emphasize curriculum development, and to improve the school. Considers the key feature of the cyclical review model to be the personal involvement of nearly every faculty member in the 10-school district. (DMM)

Foreign Language Week: A Successful Public Relations Model.

ERIC Educational Resources Information Center

Reschke, Claus

A detailed description is presented of a foreign language (FL) week project that was organized and executed by the Houston Area Teachers of Foreign Languages (HATFL) during the 1979-80 academic year. The document describes the preparation activities of the organizing committee, the pre-foreign language week advertising campaigns, the design of…

Planning Good Change with Technology and Literacy.

ERIC Educational Resources Information Center

McKenzie, Jamie

This book describes strategies to put information literacy and student learning at the center of technology planning. Filled with stories of success and with models of good planning, the book shows how to clarify purpose, involve important stakeholders, and pace the change process to maximize the daily use of new technologies. The following…

At-Risk Readers: Part II--Breaking the Cycle (Research into Practice).

ERIC Educational Resources Information Center

Goetze, Sandra K.; McElroy, Linda J.; Beach, Sara Ann

1997-01-01

Asserts that the cycle of at-risk readers' self-perception and teachers' perception can be broken by providing rich, accelerated literacy instruction. Discusses early intervention programs, such as Reading Recovery and Early Intervention in Reading, and other intervention models such as Success for All. Describes teaching strategies used to…

Community-based Services for Deaf-Blind Consumers: A Successful Rehabilitation and Vocational Model.

ERIC Educational Resources Information Center

Bourquin, Eugene; Mascia, John; Rusenski, Susan

2002-01-01

This article describes the Community Service Program (CSP) established in 1998 by the Helen Keller National Center for Deaf-Blind Youths and Adults. The CSP, which consists of a team of professional service providers, provides rehabilitation teaching, orientation and mobility services, and job development services, and help in accessing…

Reorganization and Reconfiguration of the Information Management System of Istanbul University Observatory taking the Padova - Asiago Observatory Information Management System as a Model

NASA Astrophysics Data System (ADS)

Gulsecen, S.; Saygac, A. T.; Passuello, R.; Rigoni, A.

1998-01-01

In this paper we describe the need for a more powerful Information management System (IMS) to be used as a useful aid for astronomers. The main purpose of IMS in astronomical places like observatories and astronomy departments is described and two models are presented: one to be reorganized and reconfigurated (Istanbul University,Faculty of Science, Department of Astronomy and Space Sciences -ASS- IMS) and one to be taken as a good model for the previous (University of Padova, Asiago astrophysical Observatory IMS). Particular attention is given to the implementation of the new IMS of ASS to be done carefully. In order to take success in this, the need for current and future cooperation and support in mentioned.

Large Synoptic Survey Telescope mount final design

NASA Astrophysics Data System (ADS)

Callahan, Shawn; Gressler, William; Thomas, Sandrine J.; Gessner, Chuck; Warner, Mike; Barr, Jeff; Lotz, Paul J.; Schumacher, German; Wiecha, Oliver; Angeli, George; Andrew, John; Claver, Chuck; Schoening, Bill; Sebag, Jacques; Krabbendam, Victor; Neill, Doug; Hileman, Ed; Muller, Gary; Araujo, Constanza; Orden Martinez, Alfredo; Perezagua Aguado, Manuel; García-Marchena, Luis; Ruiz de Argandoña, Ismael; Romero, Francisco M.; Rodríguez, Ricardo; Carlos González, José; Venturini, Marco

2016-08-01

This paper describes the status and details of the large synoptic survey telescope1,2,3 mount assembly (TMA). On June 9th, 2014 the contract for the design and build of the large synoptic survey telescope mount assembly (TMA) was awarded to GHESA Ingeniería y Tecnología, S.A. and Asturfeito, S.A. The design successfully passed the preliminary design review on October 2, 2015 and the final design review January 29, 2016. This paper describes the detailed design by subsystem, analytical model results, preparations being taken to complete the fabrication, and the transportation and installation plans to install the mount on Cerro Pachón in Chile. This large project is the culmination of work by many people and the authors would like to thank everyone that has contributed to the success of this project.

Item Response Theory to Quantify Longitudinal Placebo and Paliperidone Effects on PANSS Scores in Schizophrenia.

PubMed

Krekels, Ehj; Novakovic, A M; Vermeulen, A M; Friberg, L E; Karlsson, M O

2017-08-01

As biomarkers are lacking, multi-item questionnaire-based tools like the Positive and Negative Syndrome Scale (PANSS) are used to quantify disease severity in schizophrenia. Analyzing composite PANSS scores as continuous data discards information and violates the numerical nature of the scale. Here a longitudinal analysis based on Item Response Theory is presented using PANSS data from phase III clinical trials. Latent disease severity variables were derived from item-level data on the positive, negative, and general PANSS subscales each. On all subscales, the time course of placebo responses were best described with Weibull models, and dose-independent functions with exponential models to describe the onset of the full effect were used to describe paliperidone's effect. Placebo and drug effect were most pronounced on the positive subscale. The final model successfully describes the time course of treatment effects on the individual PANSS item-levels, on all PANSS subscale levels, and on the total score level. © 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

Validation of FFM PD counts for screening personality pathology and psychopathy in adolescence.

PubMed

Decuyper, Mieke; De Clercq, Barbara; De Bolle, Marleen; De Fruyt, Filip

2009-12-01

Miller and colleagues (Miller, Bagby, Pilkonis, Reynolds, & Lynam, 2005) recently developed a Five-Factor Model (FFM) personality disorder (PD) count technique for describing and diagnosing PDs and psychopathy in adulthood. This technique conceptualizes PDs relying on general trait models and uses facets from the expert-generated PD prototypes to score the FFM PDs. The present study corroborates on the study of Miller and colleagues (2005) and investigates in Study 1 whether the PD count technique shows discriminant validity to describe PDs in adolescence. Study 2 extends this objective to psychopathy. Results suggest that the FFM PD count technique is equally successful in adolescence as in adulthood to describe PD symptoms, supporting the use of this descriptive method in adolescence. The normative data and accompanying PD count benchmarks enable to use FFM scores for PD screening purposes in adolescence.

Enhanced stability of car-following model upon incorporation of short-term driving memory

NASA Astrophysics Data System (ADS)

Liu, Da-Wei; Shi, Zhong-Ke; Ai, Wen-Huan

2017-06-01

Based on the full velocity difference model, a new car-following model is developed to investigate the effect of short-term driving memory on traffic flow in this paper. Short-term driving memory is introduced as the influence factor of driver's anticipation behavior. The stability condition of the newly developed model is derived and the modified Korteweg-de Vries (mKdV) equation is constructed to describe the traffic behavior near the critical point. Via numerical method, evolution of a small perturbation is investigated firstly. The results show that the improvement of this new car-following model over the previous ones lies in the fact that the new model can improve the traffic stability. Starting and breaking processes of vehicles in the signalized intersection are also investigated. The numerical simulations illustrate that the new model can successfully describe the driver's anticipation behavior, and that the efficiency and safety of the vehicles passing through the signalized intersection are improved by considering short-term driving memory.

Scaling up spike-and-slab models for unsupervised feature learning.

PubMed

Goodfellow, Ian J; Courville, Aaron; Bengio, Yoshua

2013-08-01

We describe the use of two spike-and-slab models for modeling real-valued data, with an emphasis on their applications to object recognition. The first model, which we call spike-and-slab sparse coding (S3C), is a preexisting model for which we introduce a faster approximate inference algorithm. We introduce a deep variant of S3C, which we call the partially directed deep Boltzmann machine (PD-DBM) and extend our S3C inference algorithm for use on this model. We describe learning procedures for each. We demonstrate that our inference procedure for S3C enables scaling the model to unprecedented large problem sizes, and demonstrate that using S3C as a feature extractor results in very good object recognition performance, particularly when the number of labeled examples is low. We show that the PD-DBM generates better samples than its shallow counterpart, and that unlike DBMs or DBNs, the PD-DBM may be trained successfully without greedy layerwise training.

Developing a physiologically based approach for modeling plutonium decorporation therapy with DTPA.

PubMed

Kastl, Manuel; Giussani, Augusto; Blanchardon, Eric; Breustedt, Bastian; Fritsch, Paul; Hoeschen, Christoph; Lopez, Maria Antonia

2014-11-01

To develop a physiologically based compartmental approach for modeling plutonium decorporation therapy with the chelating agent Diethylenetriaminepentaacetic acid (Ca-DTPA/Zn-DTPA). Model calculations were performed using the software package SAAM II (©The Epsilon Group, Charlottesville, Virginia, USA). The Luciani/Polig compartmental model with age-dependent description of the bone recycling processes was used for the biokinetics of plutonium. The Luciani/Polig model was slightly modified in order to account for the speciation of plutonium in blood and for the different affinities for DTPA of the present chemical species. The introduction of two separate blood compartments, describing low-molecular-weight complexes of plutonium (Pu-LW) and transferrin-bound plutonium (Pu-Tf), respectively, and one additional compartment describing plutonium in the interstitial fluids was performed successfully. The next step of the work is the modeling of the chelation process, coupling the physiologically modified structure with the biokinetic model for DTPA. RESULTS of animal studies performed under controlled conditions will enable to better understand the principles of the involved mechanisms.

Event-triggered resilient filtering with stochastic uncertainties and successive packet dropouts via variance-constrained approach

NASA Astrophysics Data System (ADS)

Jia, Chaoqing; Hu, Jun; Chen, Dongyan; Liu, Yurong; Alsaadi, Fuad E.

2018-07-01

In this paper, we discuss the event-triggered resilient filtering problem for a class of time-varying systems subject to stochastic uncertainties and successive packet dropouts. The event-triggered mechanism is employed with hope to reduce the communication burden and save network resources. The stochastic uncertainties are considered to describe the modelling errors and the phenomenon of successive packet dropouts is characterized by a random variable obeying the Bernoulli distribution. The aim of the paper is to provide a resilient event-based filtering approach for addressed time-varying systems such that, for all stochastic uncertainties, successive packet dropouts and filter gain perturbation, an optimized upper bound of the filtering error covariance is obtained by designing the filter gain. Finally, simulations are provided to demonstrate the effectiveness of the proposed robust optimal filtering strategy.

The Integrated Medical Model: Statistical Forecasting of Risks to Crew Health and Mission Success

NASA Technical Reports Server (NTRS)

Fitts, M. A.; Kerstman, E.; Butler, D. J.; Walton, M. E.; Minard, C. G.; Saile, L. G.; Toy, S.; Myers, J.

2008-01-01

The Integrated Medical Model (IMM) helps capture and use organizational knowledge across the space medicine, training, operations, engineering, and research domains. The IMM uses this domain knowledge in the context of a mission and crew profile to forecast crew health and mission success risks. The IMM is most helpful in comparing the risk of two or more mission profiles, not as a tool for predicting absolute risk. The process of building the IMM adheres to Probability Risk Assessment (PRA) techniques described in NASA Procedural Requirement (NPR) 8705.5, and uses current evidence-based information to establish a defensible position for making decisions that help ensure crew health and mission success. The IMM quantitatively describes the following input parameters: 1) medical conditions and likelihood, 2) mission duration, 3) vehicle environment, 4) crew attributes (e.g. age, sex), 5) crew activities (e.g. EVA's, Lunar excursions), 6) diagnosis and treatment protocols (e.g. medical equipment, consumables pharmaceuticals), and 7) Crew Medical Officer (CMO) training effectiveness. It is worth reiterating that the IMM uses the data sets above as inputs. Many other risk management efforts stop at determining only likelihood. The IMM is unique in that it models not only likelihood, but risk mitigations, as well as subsequent clinical outcomes based on those mitigations. Once the mathematical relationships among the above parameters are established, the IMM uses a Monte Carlo simulation technique (a random sampling of the inputs as described by their statistical distribution) to determine the probable outcomes. Because the IMM is a stochastic model (i.e. the input parameters are represented by various statistical distributions depending on the data type), when the mission is simulated 10-50,000 times with a given set of medical capabilities (risk mitigations), a prediction of the most probable outcomes can be generated. For each mission, the IMM tracks which conditions occurred and decrements the pharmaceuticals and supplies required to diagnose and treat these medical conditions. If supplies are depleted, then the medical condition goes untreated, and crew and mission risk increase. The IMM currently models approximately 30 medical conditions. By the end of FY2008, the IMM will be modeling over 100 medical conditions, approximately 60 of which have been recorded to have occurred during short and long space missions.

Examining the patterns and dynamics of species abundance distributions in succession of forest communities by model selection.

PubMed

Yin, Zuo-Yun; Zeng, Lu; Luo, Shao-Ming; Chen, Ping; He, Xiao; Guo, Wei; Li, Bailian

2018-01-01

There are a few common species and many rare species in a biological community or a multi-species collection in given space and time. This hollow distribution curve is called species abundance distribution (SAD). Few studies have examined the patterns and dynamics of SADs during the succession of forest communities by model selection. This study explored whether the communities in different successional stages followed different SAD models and whether there existed a best SAD model to reveal their intrinsic quantitative features of structure and dynamics in succession. The abundance (the number of individuals) of each vascular plant was surveyed by quadrat sampling method from the tree, shrub and herb layers in two typical communities (i.e., the evergreen needle- and broad-leaved mixed forest and the monsoon evergreen broad-leaved forest) in southern subtropical Dinghushan Biosphere Reserve, South China. The sites of two forest communities in different successional stages are both 1 ha in area. We collected seven widely representative SAD models with obviously different function forms and transformed them into the same octave (log2) scale. These models are simultaneously confronted with eight datasets from four layers of two communities, and their goodness-of-fits to the data were evaluated by the chi-squared test, the adjusted coefficient of determination and the information criteria. The results indicated that: (1) the logCauchy model followed all the datasets and was the best among seven models; (2) the fitness of each model to the data was not directly related to the successional stage of forest community; (3) according to the SAD curves predicted by the best model (i.e., the logCauchy), the proportion of rare species decreased but that of common ones increased in the upper layers with succession, while the reverse was true in the lower layers; and (4) the difference of the SADs increased between the upper and the lower layers with succession. We concluded that the logCauchy model had the widest applicability in describing the SADs, and could best mirror the SAD patterns and dynamics of communities and their different layers in the succession of forests. The logCauchy-modeled SADs can quantitatively guide the construction of ecological forests and the restoration of degraded vegetation.

Examining the patterns and dynamics of species abundance distributions in succession of forest communities by model selection

PubMed Central

Luo, Shao-Ming; Chen, Ping; He, Xiao; Guo, Wei; Li, Bailian

2018-01-01

There are a few common species and many rare species in a biological community or a multi-species collection in given space and time. This hollow distribution curve is called species abundance distribution (SAD). Few studies have examined the patterns and dynamics of SADs during the succession of forest communities by model selection. This study explored whether the communities in different successional stages followed different SAD models and whether there existed a best SAD model to reveal their intrinsic quantitative features of structure and dynamics in succession. The abundance (the number of individuals) of each vascular plant was surveyed by quadrat sampling method from the tree, shrub and herb layers in two typical communities (i.e., the evergreen needle- and broad-leaved mixed forest and the monsoon evergreen broad-leaved forest) in southern subtropical Dinghushan Biosphere Reserve, South China. The sites of two forest communities in different successional stages are both 1 ha in area. We collected seven widely representative SAD models with obviously different function forms and transformed them into the same octave (log2) scale. These models are simultaneously confronted with eight datasets from four layers of two communities, and their goodness-of-fits to the data were evaluated by the chi-squared test, the adjusted coefficient of determination and the information criteria. The results indicated that: (1) the logCauchy model followed all the datasets and was the best among seven models; (2) the fitness of each model to the data was not directly related to the successional stage of forest community; (3) according to the SAD curves predicted by the best model (i.e., the logCauchy), the proportion of rare species decreased but that of common ones increased in the upper layers with succession, while the reverse was true in the lower layers; and (4) the difference of the SADs increased between the upper and the lower layers with succession. We concluded that the logCauchy model had the widest applicability in describing the SADs, and could best mirror the SAD patterns and dynamics of communities and their different layers in the succession of forests. The logCauchy-modeled SADs can quantitatively guide the construction of ecological forests and the restoration of degraded vegetation. PMID:29746516

The folding energy landscape and free energy excitations of cytochrome c.

PubMed

Weinkam, Patrick; Zimmermann, Jörg; Romesberg, Floyd E; Wolynes, Peter G

2010-05-18

The covalently bound heme cofactor plays a dominant role in the folding of cytochrome c. Because of the complicated inorganic chemistry of the heme, some might consider the folding of cytochrome c to be a special case, following principles different from those used to describe the folding of proteins without cofactors. Recent investigations, however, demonstrate that common models describing folding for many proteins work well for cytochrome c when heme is explicitly introduced, generally providing results that agree with experimental observations. In this Account, we first discuss results from simple native structure-based models. These models include attractive interactions between nonadjacent residues only if they are present in the crystal structure at pH 7. Because attractive nonnative contacts are not included in native structure-based models, their energy landscapes can be described as "perfectly funneled". In other words, native structure-based models are energetically guided towards the native state and contain no energetic traps that would hinder folding. Energetic traps are denoted sources of "frustration", which cause specific transient intermediates to be populated. Native structure-based models do, however, include repulsion between residues due to excluded volume. Nonenergetic traps can therefore exist if the chain, which cannot cross over itself, must partially unfold so that folding can proceed. The ability of native structure-based models to capture this kind of motion is partly responsible for their successful predictions of folding pathways for many types of proteins. Models without frustration describe the sequence of folding events for cytochrome c well (as inferred from hydrogen-exchange experiments), thereby justifying their use as a starting point. At low pH, the experimentally observed folding sequence of cytochrome c deviates from that at pH 7 and from models with perfectly funneled energy landscapes. Here, alternate folding pathways are a result of "chemical frustration". This frustration arises because some regions of the protein are destabilized more than others due to the heterogeneous distribution of titratable residues that are protonated at low pH. Beginning with native structure-based terms, we construct more complex models by adding chemical frustration. These more complex models only modestly perturb the energy landscape, which remains, overall, well funneled. These perturbed models can accurately describe how alternative folding pathways are used at low pH. At alkaline pH, cytochrome c populates distinctly different structural ensembles. For instance, lysine residues are deprotonated and compete for the heme ligation site. The same models that can describe folding at low pH also predict well the structures and relative stabilities of intermediates populated at alkaline pH. The success of models based on funneled energy landscapes suggest that cytochrome c folding is driven primarily by native contacts. The presence of heme appears to add chemical complexity to the folding process, but it does not require fundamental modification of the general principles used to describe folding. Moreover, its added complexity provides a valuable means of probing the folding energy landscape in greater detail than is possible with simpler systems.

Modeling and Scaling of the Distribution of Trade Avalanches in a STOCK Market

NASA Astrophysics Data System (ADS)

Kim, Hyun-Joo

We study the trading activity in the Korea Stock Exchange by considering trade avalanches. A series of successive trading with small trade time interval is regarded as a trade avalanche of which the size s is defined as the number of trade in a series of successive trades. We measure the distribution of trade avalanches sizes P(s) and find that it follows the power-law behavior P(s) ~ s-α with the exponent α ≈ 2 for two stocks with the largest number of trades. A simple stochastic model which describes the power-law behavior of the distribution of trade avalanche size is introduced. In the model it is assumed that the some trades induce the accompanying trades, which results in the trade avalanches and we find that the distribution of the trade avalanche size also follows power-law behavior with the exponent α ≈ 2.

Performance Enhancement of a Full-Scale Vertical Tail Model Equipped with Active Flow Control

NASA Technical Reports Server (NTRS)

Whalen, Edward A.; Lacy, Douglas; Lin, John C.; Andino, Marlyn Y.; Washburn, Anthony E.; Graff, Emilio; Wygnanski, Israel J.

2015-01-01

This paper describes wind tunnel test results from a joint NASA/Boeing research effort to advance active flow control (AFC) technology to enhance aerodynamic efficiency. A full-scale Boeing 757 vertical tail model equipped with sweeping jet actuators was tested at the National Full-Scale Aerodynamics Complex (NFAC) 40- by 80-Foot Wind Tunnel (40x80) at NASA Ames Research Center. The model was tested at a nominal airspeed of 100 knots and across rudder deflections and sideslip angles that covered the vertical tail flight envelope. A successful demonstration of AFC-enhanced vertical tail technology was achieved. A 31- actuator configuration significantly increased side force (by greater than 20%) at a maximum rudder deflection of 30deg. The successful demonstration of this application has cleared the way for a flight demonstration on the Boeing 757 ecoDemonstrator in 2015.

The Consumer Health Information System Adoption Model.

PubMed

Monkman, Helen; Kushniruk, Andre W

2015-01-01

Derived from overlapping concepts in consumer health, a consumer health information system refers to any of the broad range of applications, tools, and educational resources developed to empower consumers with knowledge, techniques, and strategies, to manage their own health. As consumer health information systems become increasingly popular, it is important to explore the factors that impact their adoption and success. Accumulating evidence indicates a relationship between usability and consumers' eHealth Literacy skills and the demands consumer HISs place on their skills. Here, we present a new model called the Consumer Health Information System Adoption Model, which depicts both consumer eHealth literacy skills and system demands on eHealth literacy as moderators with the potential to affect the strength of relationship between usefulness and usability (predictors of usage) and adoption, value, and successful use (actual usage outcomes). Strategies for aligning these two moderating factors are described.

Trap-assisted transition between Schottky emission and Fowler-Nordheim tunneling in the interfacial-memristor based on Bi2S3 nano-networks

NASA Astrophysics Data System (ADS)

Tian, Ye; Jiang, Lianjun; Zhang, Xuejun; Zhang, Guangfu; Zhu, Qiuxiang

2018-03-01

For the usage of the memristors in functional circuits, a predictive physical model is of great importance. However, other than the developments of the memristive models accounting bulky effects, the achievements on simulating the interfacial memristance are still insufficient. Here we provide a physical model to describe the electrical switching of the memristive interface. It considers the trap-assisted transition between Schottky emission and Fowler-Nordheim tunneling, and successfully reproduces the memristive behaviors occurring on the interface between Bi2S3 nano-networks and F-doped SnO2. Such success not only allows us uncover several features of the memristive interface including the distribution nature of the traps, barrier height/thickness and so on, but also provides a foundation from which we can quantitatively simulate the real interfacial memristor.

Langevin Equation for DNA Dynamics

NASA Astrophysics Data System (ADS)

Grych, David; Copperman, Jeremy; Guenza, Marina

Under physiological conditions, DNA oligomers can contain well-ordered helical regions and also flexible single-stranded regions. We describe the site-specific motion of DNA with a modified Rouse-Zimm Langevin equation formalism that describes DNA as a coarse-grained polymeric chain with global structure and local flexibility. The approach has successfully described the protein dynamics in solution and has been extended to nucleic acids. Our approach provides diffusive mode analytical solutions for the dynamics of global rotational diffusion and internal motion. The internal DNA dynamics present a rich energy landscape that accounts for an interior where hydrogen bonds and base-stacking determine structure and experience limited solvent exposure. We have implemented several models incorporating different coarse-grained sites with anisotropic rotation, energy barrier crossing, and local friction coefficients that include a unique internal viscosity and our models reproduce dynamics predicted by atomistic simulations. The models reproduce bond autocorrelation along the sequence as compared to that directly calculated from atomistic molecular dynamics simulations. The Langevin equation approach captures the essence of DNA dynamics without a cumbersome atomistic representation.

Every Citizen a Soldier: Historic Foundations for Gender Integrated Training (GIT) and Implications for Air Force Readiness

DTIC Science & Technology

1999-04-01

masculine world. Noted military experts suggest pluralism is the desired end state for successful gender integrated service, and this concept is...book in progress, Dr. Dunivin discusses two, current U.S. 5 military culture models. The first is the Traditional Model, termed the Combat Masculine ... Masculine Warrior. Charles Moskos, cited by Dunivin, describes what the 6 Combat Masculine Warrior paradigm actually means to the military: “Thus a

Partnerships in Pharma--An Economist Intelligence Unit Seminar--Building Innovation into Alliances and Business Models. 1 October 2010, London, UK.

PubMed

Kibble, Alexandra

2010-12-01

The Partnerships in Pharma seminar, held in London, included topics related to building innovation into alliances and business models within the pharmaceutical industry. This conference report highlights selected presentations on strategies for successful partnering, partnering alongside an evolving CRO industry, considering the pharma value chain, and partnerships between industry and academia. Approaches used by Ipsen, Merck Serono, Pfizer and ViiV Healthcare are also described.

Biomedical systems analysis program

NASA Technical Reports Server (NTRS)

1979-01-01

Biomedical monitoring programs which were developed to provide a system analysis context for a unified hypothesis for adaptation to space flight are presented and discussed. A real-time system of data analysis and decision making to assure the greatest possible crew safety and mission success is described. Information about man's abilities, limitations, and characteristic reactions to weightless space flight was analyzed and simulation models were developed. The predictive capabilities of simulation models for fluid-electrolyte regulation, erythropoiesis regulation, and calcium regulation are discussed.

Exploring Middle School Students' Understanding of Three Conceptual Models in Genetics

NASA Astrophysics Data System (ADS)

Bresler Freidenreich, Hava; Golan Duncan, Ravit; Shea, Nicole

2011-11-01

Genetics is the cornerstone of modern biology and a critical aspect of scientific literacy. Research has shown, however, that many high school graduates lack fundamental understandings in genetics necessary to make informed decisions about issues and emerging technologies in this domain, such as genetic screening, genetically modified foods, etc. Genetic literacy entails understanding three interrelated models: a genetic model that describes patterns of genetic inheritance, a meiotic model that describes the process by which genes are segregated into sex cells, and a molecular model that describes the mechanisms that link genotypes to phenotypes within an individual. Currently, much of genetics instruction, especially in terms of the molecular model, occurs at the high school level, and we know little about the ways in which middle school students can reason about these models. Furthermore, we do not know the extent to which carefully designed instruction can help younger students develop coherent and interrelated understandings in genetics. In this paper, we discuss a research study aimed at elucidating middle school students' abilities to reason about the three genetic models. As part of our research, we designed an eight-week inquiry unit that was implemented in a combined sixth- to eighth-grade science classroom. We describe our instructional design and report results based on an analysis of written assessments, clinical interviews, and artifacts of the unit. Our findings suggest that middle school students are able to successfully reason about all three genetic models.

Modeling fuel succession

USGS Publications Warehouse

Davis, Brett; Van Wagtendonk, Jan W.; Beck, Jen; van Wagtendonk, Kent A.

2009-01-01

Surface fuels data are of critical importance for supporting fire incident management, risk assessment, and fuel management planning, but the development of surface fuels data can be expensive and time consuming. The data development process is extensive, generally beginning with acquisition of remotely sensed spatial data such as aerial photography or satellite imagery (Keane and others 2001). The spatial vegetation data are then crosswalked to a set of fire behavior fuel models that describe the available fuels (the burnable portions of the vegetation) (Anderson 1982, Scott and Burgan 2005). Finally, spatial fuels data are used as input to tools such as FARSITE and FlamMap to model current and potential fire spread and behavior (Finney 1998, Finney 2006). The capture date of the remotely sensed data defines the period for which the vegetation, and, therefore, fuels, data are most accurate. The more time that passes after the capture date, the less accurate the data become due to vegetation growth and processes such as fire. Subsequently, the results of any fire simulation based on these data become less accurate as the data age. Because of the amount of labor and expense required to develop these data, keeping them updated may prove to be a challenge. In this article, we describe the Sierra Nevada Fuel Succession Model, a modeling tool that can quickly and easily update surface fuel models with a minimum of additional input data. Although it was developed for use by Yosemite, Sequoia, and Kings Canyon National Parks, it is applicable to much of the central and southern Sierra Nevada. Furthermore, the methods used to develop the model have national applicability.

A model for tracking concentration of chemical compounds within a tank of an automatic film processor.

PubMed

Sobol, Wlad T

2002-01-01

A simple kinetic model that describes the time evolution of the chemical concentration of an arbitrary compound within the tank of an automatic film processor is presented. It provides insights into the kinetics of chemistry concentration inside the processor's tank; the results facilitate the tasks of processor tuning and quality control (QC). The model has successfully been used in several troubleshooting sessions of low-volume mammography processors for which maintaining consistent QC tracking was difficult due to fluctuations of bromide levels in the developer tank.

The case for the relativistic hot big bang cosmology

NASA Technical Reports Server (NTRS)

Peebles, P. J. E.; Schramm, D. N.; Kron, R. G.; Turner, E. L.

1991-01-01

What has become the standard model in cosmology is described, and some highlights are presented of the now substantial range of evidence that most cosmologists believe convincingly establishes this model, the relativistic hot big bang cosmology. It is shown that this model has yielded a set of interpretations and successful predictions that substantially outnumber the elements used in devising the theory, with no well-established empirical contradictions. Brief speculations are made on how the open puzzles and work in progress might affect future developments in this field.

Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology

PubMed Central

Leung, Maxwell C. K.; Williams, Phillip L.; Benedetto, Alexandre; Au, Catherine; Helmcke, Kirsten J.; Aschner, Michael; Meyer, Joel N.

2008-01-01

The nematode Caenorhabditis elegans has emerged as an important animal model in various fields including neurobiology, developmental biology, and genetics. Characteristics of this animal model that have contributed to its success include its genetic manipulability, invariant and fully described developmental program, well-characterized genome, ease of maintenance, short and prolific life cycle, and small body size. These same features have led to an increasing use of C. elegans in toxicology, both for mechanistic studies and high-throughput screening approaches. We describe some of the research that has been carried out in the areas of neurotoxicology, genetic toxicology, and environmental toxicology, as well as high-throughput experiments with C. elegans including genome-wide screening for molecular targets of toxicity and rapid toxicity assessment for new chemicals. We argue for an increased role for C. elegans in complementing other model systems in toxicological research. PMID:18566021

The Center For Medicare And Medicaid Innovation's blueprint for rapid-cycle evaluation of new care and payment models.

PubMed

Shrank, William

2013-04-01

The Affordable Care Act established the Center for Medicare and Medicaid Innovation to test innovative payment and service delivery models. The goal is to reduce program expenditures while preserving or improving the quality of care provided to beneficiaries of Medicare, Medicaid, and the Children's Health Insurance Program. Central to the success of the Innovation Center is a new, rapid-cycle approach to evaluation. This article describes that approach--setting forth how the Rapid Cycle Evaluation Group aims to deliver frequent feedback to providers in support of continuous quality improvement, while rigorously evaluating the outcomes of each model tested. This article also describes the relationship between the group's work and that of the Office of the Actuary at the Centers for Medicare and Medicaid Services, which plays a central role in the assessment of new models.

The "GeneTrustee": a universal identification system that ensures privacy and confidentiality for human genetic databases.

PubMed

Burnett, Leslie; Barlow-Stewart, Kris; Proos, Anné L; Aizenberg, Harry

2003-05-01

This article describes a generic model for access to samples and information in human genetic databases. The model utilises a "GeneTrustee", a third-party intermediary independent of the subjects and of the investigators or database custodians. The GeneTrustee model has been implemented successfully in various community genetics screening programs and has facilitated research access to genetic databases while protecting the privacy and confidentiality of research subjects. The GeneTrustee model could also be applied to various types of non-conventional genetic databases, including neonatal screening Guthrie card collections, and to forensic DNA samples.

An evidence-based structure for transformative nurse executive practice: the model of the interrelationship of leadership, environments, and outcomes for nurse executives (MILE ONE).

PubMed

Adams, Jeffrey M; Erickson, Jeanette Ives; Jones, Dorothy A; Paulo, Lisa

2009-01-01

Identifying and measuring success within the chief nurse executive (CNE) population have proven complex and challenging for nurse executive educators, policy makers, practitioners, researchers, theory developers, and their constituents. The model of the interrelationship of leadership, environments, and outcomes for nurse executives (MILE ONE) was developed using the concept of consilience (jumping together of ideas) toward limiting the ambiguity surrounding CNE success. The MILE ONE is unique in that it links existing evidence and identifies the continuous and dependent interrelationship among 3 content areas: (1) CNE; (2) nurses' professional practice and work environments; and (3) patient and organizational outcomes. The MILE ONE was developed to operationalize nurse executive influence, define measurement of CNE success, and provide a framework to articulate for patient, workforce, and organizational outcome improvement efforts. This article describes the MILE ONE and highlights the evidence base structure used in its development.

Nonlinear filtering techniques for noisy geophysical data: Using big data to predict the future

NASA Astrophysics Data System (ADS)

Moore, J. M.

2014-12-01

Chaos is ubiquitous in physical systems. Within the Earth sciences it is readily evident in seismology, groundwater flows and drilling data. Models and workflows have been applied successfully to understand and even to predict chaotic systems in other scientific fields, including electrical engineering, neurology and oceanography. Unfortunately, the high levels of noise characteristic of our planet's chaotic processes often render these frameworks ineffective. This contribution presents techniques for the reduction of noise associated with measurements of nonlinear systems. Our ultimate aim is to develop data assimilation techniques for forward models that describe chaotic observations, such as episodic tremor and slip (ETS) events in fault zones. A series of nonlinear filters are presented and evaluated using classical chaotic systems. To investigate whether the filters can successfully mitigate the effect of noise typical of Earth science, they are applied to sunspot data. The filtered data can be used successfully to forecast sunspot evolution for up to eight years (see figure).

Mutual and asynchronous anticipation and action in sports as globally competitive and locally coordinative dynamics

PubMed Central

Fujii, Keisuke; Isaka, Tadao; Kouzaki, Motoki; Yamamoto, Yuji

2015-01-01

Humans interact by changing their actions, perceiving other’s actions and executing solutions in conflicting situations. Using oscillator models, nonlinear dynamics have been considered for describing these complex human movements as an emergence of self-organisation. However, these frameworks cannot explain the hierarchical structures of complex behaviours between conflicting inter-agent and adapting intra-agent systems, especially in sport competitions wherein mutually quick decision making and execution are required. Here we adopt a hybrid multiscale approach to model an attack-and-defend game during which both players predict the opponent’s movement and move with a delay. From both simulated and measured data, one synchronous outcome between two-agent (i.e. successful defence) can be described as one attractor. In contrast, the other coordination-breaking outcome (i.e. successful attack) cannot be explained using gradient dynamics because the asymmetric interaction cannot always assume a conserved physical quantity. Instead, we provide the asymmetric and asynchronous hierarchical dynamical models to discuss two-agent competition. Our framework suggests that possessing information about an opponent and oneself in local-coordinative and global-competitive scale enables us to gain a deeper understanding of sports competitions. We anticipate developments in the scientific fields of complex movement adapting to such uncontrolled environments. PMID:26538452

Mutual and asynchronous anticipation and action in sports as globally competitive and locally coordinative dynamics

NASA Astrophysics Data System (ADS)

Fujii, Keisuke; Isaka, Tadao; Kouzaki, Motoki; Yamamoto, Yuji

2015-11-01

Humans interact by changing their actions, perceiving other’s actions and executing solutions in conflicting situations. Using oscillator models, nonlinear dynamics have been considered for describing these complex human movements as an emergence of self-organisation. However, these frameworks cannot explain the hierarchical structures of complex behaviours between conflicting inter-agent and adapting intra-agent systems, especially in sport competitions wherein mutually quick decision making and execution are required. Here we adopt a hybrid multiscale approach to model an attack-and-defend game during which both players predict the opponent’s movement and move with a delay. From both simulated and measured data, one synchronous outcome between two-agent (i.e. successful defence) can be described as one attractor. In contrast, the other coordination-breaking outcome (i.e. successful attack) cannot be explained using gradient dynamics because the asymmetric interaction cannot always assume a conserved physical quantity. Instead, we provide the asymmetric and asynchronous hierarchical dynamical models to discuss two-agent competition. Our framework suggests that possessing information about an opponent and oneself in local-coordinative and global-competitive scale enables us to gain a deeper understanding of sports competitions. We anticipate developments in the scientific fields of complex movement adapting to such uncontrolled environments.

Generation of transgenic mouse model using PTTG as an oncogene.

PubMed

Kakar, Sham S; Kakar, Cohin

2015-01-01

The close physiological similarity between the mouse and human has provided tools to understanding the biological function of particular genes in vivo by introduction or deletion of a gene of interest. Using a mouse as a model has provided a wealth of resources, knowledge, and technology, helping scientists to understand the biological functions, translocation, trafficking, and interaction of a candidate gene with other intracellular molecules, transcriptional regulation, posttranslational modification, and discovery of novel signaling pathways for a particular gene. Most importantly, the generation of the mouse model for a specific human disease has provided a powerful tool to understand the etiology of a disease and discovery of novel therapeutics. This chapter describes in detail the step-by-step generation of the transgenic mouse model, which can be helpful in guiding new investigators in developing successful models. For practical purposes, we will describe the generation of a mouse model using pituitary tumor transforming gene (PTTG) as the candidate gene of interest.

Mechanistic modelling of drug release from a polymer matrix using magnetic resonance microimaging.

PubMed

Kaunisto, Erik; Tajarobi, Farhad; Abrahmsen-Alami, Susanna; Larsson, Anette; Nilsson, Bernt; Axelsson, Anders

2013-03-12

In this paper a new model describing drug release from a polymer matrix tablet is presented. The utilization of the model is described as a two step process where, initially, polymer parameters are obtained from a previously published pure polymer dissolution model. The results are then combined with drug parameters obtained from literature data in the new model to predict solvent and drug concentration profiles and polymer and drug release profiles. The modelling approach was applied to the case of a HPMC matrix highly loaded with mannitol (model drug). The results showed that the drug release rate can be successfully predicted, using the suggested modelling approach. However, the model was not able to accurately predict the polymer release profile, possibly due to the sparse amount of usable pure polymer dissolution data. In addition to the case study, a sensitivity analysis of model parameters relevant to drug release was performed. The analysis revealed important information that can be useful in the drug formulation process. Copyright © 2013 Elsevier B.V. All rights reserved.

Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model.

PubMed

Lin, Wen; Ji, Tao; Einolf, Heidi; Ayalasomayajula, Surya; Lin, Tsu-Han; Hanna, Imad; Heimbach, Tycho; Breen, Christopher; Jarugula, Venkateswar; He, Handan

2017-05-01

Sacubitril/valsartan (LCZ696) has been approved for the treatment of heart failure. Sacubitril is an in vitro inhibitor of organic anion-transporting polypeptides (OATPs). In clinical studies, LCZ696 increased atorvastatin C max by 1.7-fold and area under the plasma concentration-time curve by 1.3-fold, but had little or no effect on simvastatin or simvastatin acid exposure. A physiologically based pharmacokinetics modeling approach was applied to explore the underlying mechanisms behind the statin-specific LCZ696 drug interaction observations. The model incorporated OATP-mediated clearance (CL int,T ) for simvastatin and simvastatin acid to successfully describe the pharmacokinetic profiles of either analyte in the absence or presence of LCZ696. Moreover, the model successfully described the clinically observed drug effect with atorvastatin. The simulations clarified the critical parameters responsible for the observation of a low, yet clinically relevant, drug-drug interaction DDI between sacubitril and atorvastatin and the lack of effect with simvastatin acid. Atorvastatin is administered in its active form and rapidly achieves C max that coincide with the low C max of sacubitril. In contrast, simvastatin requires a hydrolysis step to the acid form and therefore is not present at the site of interactions at sacubitril concentrations that are inhibitory. Similar models were used to evaluate the drug-drug interaction risk for additional OATP-transported statins which predicted to maximally result in a 1.5-fold exposure increase. Copyright © 2017. Published by Elsevier Inc.

Simulation of generation of new ideas for new product development and IT services

NASA Astrophysics Data System (ADS)

Nasiopoulos, Dimitrios K.; Sakas, Damianos P.; Vlachos, D. S.; Mavrogianni, Amanda

2015-02-01

This paper describes a dynamic model of the New Product Development (NPD) process. The model has been occurring from best practice noticed in our research conducted at a range of situations. The model contributes to determine and put an IT company's NPD activities into the frame of the overall NPD process[1]. It has been found to be a useful tool for organizing data on IT company's NPD activities without enforcement an excessively restrictive research methodology refers to the model of NPD. The framework, which strengthens the model, will help to promote a research of the methods undertaken within an IT company's NPD process, thus promoting understanding and improvement of the simulation process[2]. IT companies tested many techniques with several different practices designed to improve the validity and efficacy of their NPD process[3]. Supported by the model, this research examines how widely accepted stated tactics are and what impact these best tactics have on NPD performance. The main assumption of this study is that simulation of generation of new ideas[4] will lead to greater NPD effectiveness and more successful products in IT companies. With the model implementation, practices concern the implementation strategies of NPD (product selection, objectives, leadership, marketing strategy and customer satisfaction) are all more widely accepted than best practices related with controlling the application of NPD (process control, measurements, results). In linking simulation with impact, our results states product success depends on developing strong products and ensuring organizational emphasis, through proper project selection. Project activities strengthens both product and project success. IT products and services success also depends on monitoring the NPD procedure through project management and ensuring team consistency with group rewards. Sharing experiences between projects can positively influence the NPD process.

Business model design for a wearable biofeedback system.

PubMed

Hidefjäll, Patrik; Titkova, Dina

2015-01-01

Wearable sensor technologies used to track daily activities have become successful in the consumer market. In order for wearable sensor technology to offer added value in the more challenging areas of stress-rehab care and occupational health stress-related biofeedback parameters need to be monitored and more elaborate business models are needed. To identify probable success factors for a wearable biofeedback system (Affective Health) in the two mentioned market segments in a Swedish setting, we conducted literature studies and interviews with relevant representatives. Data were collected and used first to describe the two market segments and then to define likely feasible business model designs, according to the Business Model Canvas framework. Needs of stakeholders were identified as inputs to business model design. Value propositions, a key building block of a business model, were defined for each segment. The value proposition for occupational health was defined as "A tool that can both identify employees at risk of stress-related disorders and reinforce healthy sustainable behavior" and for healthcare as: "Providing therapists with objective data about the patient's emotional state and motivating patients to better engage in the treatment process".

Three-Dimensional Printing: An Aid to Epidural Access for Neuromodulation.

PubMed

Taverner, Murray G; Monagle, John P

2017-08-01

The case report details to use of three-dimensional (3D) printing as an aid to neuromodulation. A patient is described in whom previous attempts at spinal neuromodulation had failed due to lack of epidural or intrathecal access, and the use of a 3D printed model allowed for improved planning and ultimately, success. Successful spinal cord stimulation was achieved with the plan developed by access to a 3D model of the patient's spine. Neuromodulation techniques can provide the optimal analgesic techniques for individual patients. At times these can fail due to lack of access to the site for intervention, in this case epidural access. 3D printing may provide additional information to improve the likelihood of access when anatomy is distorted and standard approaches prove difficult. © 2017 International Neuromodulation Society.

Establishing access to technology: an evaluation and intervention model to increase the participation of children with cerebral palsy.

PubMed

McCarty, Elizabeth; Morress, Claire

2009-08-01

Children with a diagnosis of cerebral palsy often have significant physical limitations that prevent exploration and full participation in the environment. Assistive technology systems can provide opportunities for children with physical limitations to interact with their world, enabling play, communication, and daily living skills. Efficient access to and control of the technology is critical for successful use; however, establishing consistent access is often difficult because of the nature of the movement patterns exhibited by children with cerebral palsy. This article describes a 3-phase model of evaluation and intervention developed and used by Assistive Technology Services at the Aaron W. Perlman Center, Cincinnati Children's Hospital Medical Center, to establish successful access to technology systems in children with cerebral palsy.

Moving evidence-based drug abuse prevention programs from basic science to practice: "bridging the efficacy-effectiveness interface".

PubMed

August, Gerald J; Winters, Ken C; Realmuto, George M; Tarter, Ralph; Perry, Cheryl; Hektner, Joel M

2004-01-01

This article examines the challenges faced by developers of youth drug abuse prevention programs in transporting scientifically proven or evidence-based programs into natural community practice systems. Models for research on the transfer of prevention technology are described with specific emphasis given to the relationship between efficacy and effectiveness studies. Barriers that impede the successful integration of efficacy methods within effectiveness studies (e.g., client factors, practitioner factors, intervention structure characteristics, and environmental and organizational factors) are discussed. We present a modified model for program development and evaluation that includes a new type of research design, the hybrid efficacy-effectiveness study that addresses program transportability. The utility of the hybrid study is illustrated in the evaluation of the Early Risers "Skills for Success" prevention program.

Disease management interventions II: What else is in the black box?

PubMed

Linden, Ariel; Butterworth, Susan W; Roberts, Nancy

2006-04-01

The success of any disease management (DM) program ultimately depends upon the ability and willingness of participants to change and maintain desired health behaviors. To achieve those results, DM program administrators have several issues to consider, including the type of behavioral change desired, the scope of intervention that the organization is willing and capable of implementing, and whether the appropriate support structures are available to ensure successful achievement of program goals. An understanding of these issues will assist program designers in selecting the appropriate change models. This paper serves as an extension of our prior paper in which eight core psychosocial behavioral change models were described. Here, five more recently developed theory-based approaches are introduced, providing readers with up-to-date information in this area.

Using a MOOC Format for a Precalculus Course

ERIC Educational Resources Information Center

Townsley, Lisa

2016-01-01

We describe recent attempts by the University System of Georgia to develop and pilot a system-wide online Precalculus course for credit. The course was based on full online delivery, using an emporium model for learning. We experienced moderate success with the course, with a completion rate of 61-76% compared with the 4-7% for Massive Open Online…

Building Virtually Free Subject Area Expertise through Social Media: An Exploratory Study

ERIC Educational Resources Information Center

Kooy, Brian K.

2016-01-01

Central to the ongoing success of the liaison model is the need for liaison librarians to stay informed and up-to-date about recent developments in the subject areas of their assigned academic departments and programs. This article describes an exploratory study conducted to determine whether information obtained from the social media accounts of…

Assessing Peer Leader Skill Acquisition and Group Dynamics in a First-Year Calculus Course

ERIC Educational Resources Information Center

Glover, Rebecca; Hammond, Nicholas B.; Smith, Justin; Guerra, Dalyana

2018-01-01

Peer-led team learning (PLTL), specifically the model known as 'Workshops', has been shown to contribute positively and significantly to student success in STEM courses across subjects (Gosser et al., 2001). Our research adds to the SOTL literature describing the effectiveness of Workshops by reporting on the changes in student leaders. We examine…

The Use Value of "Fight Club" in Teaching Theories of Religion

ERIC Educational Resources Information Center

Smith, William E.

2008-01-01

Teaching theories and methods for the academic study of religion poses certain challenges, especially when first-year students are the primary targeted audience. In the following note from the classroom, the author describes a model for successfully employing the film "Fight Club" as a case study for exploring some of the theoretical concepts of…

Back to the Agora: Workable Solutions for Small Urban School Facilities. ERIC Digest.

ERIC Educational Resources Information Center

Lawrence, Barbara Kent

The ancient Athenian "agora" functioned as a marketplace for ideas and commerce and offered an ideal place for teaching and learning. This digest suggests adapting such a model to modern needs and describes successful small schools that have done so while reducing costs. Research shows that small schools offer many advantages for…

An antenna pointing mechanism for large reflector antennas

NASA Technical Reports Server (NTRS)

Heimerdinger, H.

1981-01-01

An antenna pointing mechanism for large reflector antennas on direct broadcasting communication satellites was built and tested. After listing the requirements and constraints for this equipment the model is described, and performance figures are given. Futhermore, results of the qualification level tests, including functional, vibrational, thermovacuum, and accelerated life tests are reported. These tests were completed successfully.

Development of techniques for processing metal-metal oxide systems

NASA Technical Reports Server (NTRS)

Johnson, P. C.

1976-01-01

Techniques for producing model metal-metal oxide systems for the purpose of evaluating the results of processing such systems in the low-gravity environment afforded by a drop tower facility are described. Because of the lack of success in producing suitable materials samples and techniques for processing in the 3.5 seconds available, the program was discontinued.

Learning while Earning: Worksite Literacy Programs. Foresight: Model Programs for Economic Development.

ERIC Educational Resources Information Center

Rosenfeld, Stuart A.; And Others

This paper describes four successful and innovative workplace-based literacy programs in the South. The first is a joint program for city municipal workers between the U.S. Naval Air Station in Memphis, Tennessee and the Memphis Literacy Coalition (Project Literacy-Memphis, Inc.). The second is a program at North Carolina State University in…

Model Dropout Prevention Program at Reidsville Middle School: A Case Study Evaluation.

ERIC Educational Resources Information Center

O'Sullivan, Rita G.

This case study describes a 2-year (1988-90) demonstration dropout prevention program, a collaboration between a rural school and a university. The dropout prevention program attempts to identify effective teaching strategies that will increase the academic successes of at-risk sixth-grade students and expand the use of those strategies among the…

Taking a Leap of Faith: Redefining Teaching and Learning in Higher Education through Project-Based Learning

ERIC Educational Resources Information Center

Lee, Jean S.; Blackwell, Sue; Drake, Jennifer; Moran, Kathryn A.

2014-01-01

This study examines two aspects of teaching with a project-based learning (PBL) model in higher education settings: faculty definitions of PBL and faculty PBL practices, as evidenced by their self-described successes and challenges in implementation. Faculty participants took "a leap of faith" in their teaching practices to redefine what…

Users' Perceptions of the Web As Revealed by Transaction Log Analysis.

ERIC Educational Resources Information Center

Moukdad, Haidar; Large, Andrew

2001-01-01

Describes the results of a transaction log analysis of a Web search engine, WebCrawler, to analyze user's queries for information retrieval. Results suggest most users do not employ advanced search features, and the linguistic structure often resembles a human-human communication model that is not always successful in human-computer communication.…

Meeting EFA: How Do Complementary Models Meet the Education Needs of Underserved Populations in Developing Countries? Issues Brief

ERIC Educational Resources Information Center

DeStefano, Joseph; Moore, Audrey-Marie Schuh; Balwanz, David; Hartwell, Ash

2006-01-01

This issues brief describes how complementary education approaches that rely on community, nongovernmental, and ministry collaboration present a promising response to the challenge to the limitations of conventional primary schooling. The brief is based on nine case studies of successful complementary education programs in Afghanistan, Bangladesh,…

Can We Measure Success in Preventing Child Abuse? Issues in Policy, Programming and Research.

ERIC Educational Resources Information Center

Garbarino, James

1986-01-01

The article reviews efforts to set child abuse prevention goals in the U.S., noting research on program effectiveness and the role of maltreatment in child mortality. Alternative models for assessing the impact of prevention are described and the need to clarify and specify goals in prevention is stressed. (CL)

Recruitment and Retention of Minorities in Teacher Education: Performance Assessment. Proceedings of the National Conference (7th, Lexington, Kentucky, January 17 - 19, 1993).

ERIC Educational Resources Information Center

Middleton, E., Ed.; And Others

This conference proceedings monograph presents 20 papers describing initiatives that deal with the recruitment and retention of minorities in education. Papers have the following titles and authors: (1) "Recruitment and Retention of Minority Scholarship and Grant Recipients: Identifying Successful Models" (Teresa Unseld); (2) "An…

Widening the Circle: Culturally Relevant Pedagogy for American Indian Children.

ERIC Educational Resources Information Center

Klug, Beverly J.; Whitfield, Patricia T.

This book provides non-Native teachers with information about Native American cultures and offers a pedagogical model that blends Native and non-Native worldviews and methodologies. The book aims to describe the process of becoming bicultural as it relates to success in teaching Native students; provide a short history of American Indian nations,…

Ladders to Success: Enhancing Transfer from Technical Associate in Science Degrees to Baccalaureates. AIR 1999 Annual Forum Paper.

ERIC Educational Resources Information Center

Pitter, Gita Wijesinghe

This paper describes the collaborative activities which have developed since 1998 Florida legislation that required stronger articulation between Associate in Science (AS) programs at state community colleges and baccalaureate programs at universities. Three major models of AS to baccalaureate articulation are evaluated: (1) a statewide career…

Spatially explicit and stochastic simulation of forest landscape fire disturbance and succession

Treesearch

Hong S. He; David J. Mladenoff

1999-01-01

Understanding disturbance and recovery of forest landscapes is a challenge because of complex interactions over a range of temporal and spatial scales. Landscape simulation models offer an approach to studying such systems at broad scales. Fire can be simulated spatially using mechanistic or stochastic approaches. We describe the fire module in a spatially explicit,...

Locally Bayesian Learning with Applications to Retrospective Revaluation and Highlighting

ERIC Educational Resources Information Center

Kruschke, John K.

2006-01-01

A scheme is described for locally Bayesian parameter updating in models structured as successions of component functions. The essential idea is to back-propagate the target data to interior modules, such that an interior component's target is the input to the next component that maximizes the probability of the next component's target. Each layer…

Skepticism to Success: Meeting Critical Workforce Needs through Innovation and Collaboration

ERIC Educational Resources Information Center

Anderson, Margaret; Maier, Linda; Shepard, Michael

2010-01-01

To meet workforce demand and the needs of working or place-bound students, Whatcom Community College developed an online version of its existing face-to-face Physical Therapist Assistant program which became a model for other lab-based health science degrees. This article describes research studies that support the program's practices and includes…

Final Technical Report: Collaborative Research Center for Nonlinear Simulation of Energetic Particles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berk, Herbert L.

2018-02-15

The study of this project focused on developing a reduced nonlinear model to describe chirping processes in a fusion plasma. A successful method was developed with results clear enough to allow an analytic theory to be developed that replicates the long term response of a nonlinear phase space structure immersed in the MHD continnuum.

The Etiology of Top-Tier Publications in Management: A Status Attainment Perspective on Academic Career Success

ERIC Educational Resources Information Center

Valle, Matthew; Schultz, Kaitlyn

2011-01-01

Purpose: The purpose of this paper is to develop and test a comprehensive model of personal and institutional input variables, composed of elements describing status-based antecedents, job/organizational context antecedents, and individual level antecedents, which may contribute to the production of significant (top-tier) research outputs in the…

Simple and Cooperatively Built Wave Motion Demonstrator

ERIC Educational Resources Information Center

Cortel, Adolf

2006-01-01

Some designs of simple wave demonstration devices have been described in this journal and elsewhere. A new simple model can be built using only dowels, binder clips, and loops of thread. Not only can it be easily assembled, stored, or disassembled, but also all the students in a class can cooperate in its building by connecting successive pieces…

Variable classification in the LSST era: exploring a model for quasi-periodic light curves

NASA Astrophysics Data System (ADS)

Zinn, J. C.; Kochanek, C. S.; Kozłowski, S.; Udalski, A.; Szymański, M. K.; Soszyński, I.; Wyrzykowski, Ł.; Ulaczyk, K.; Poleski, R.; Pietrukowicz, P.; Skowron, J.; Mróz, P.; Pawlak, M.

2017-06-01

The Large Synoptic Survey Telescope (LSST) is expected to yield ˜107 light curves over the course of its mission, which will require a concerted effort in automated classification. Stochastic processes provide one means of quantitatively describing variability with the potential advantage over simple light-curve statistics that the parameters may be physically meaningful. Here, we survey a large sample of periodic, quasi-periodic and stochastic Optical Gravitational Lensing Experiment-III variables using the damped random walk (DRW; CARMA(1,0)) and quasi-periodic oscillation (QPO; CARMA(2,1)) stochastic process models. The QPO model is described by an amplitude, a period and a coherence time-scale, while the DRW has only an amplitude and a time-scale. We find that the periodic and quasi-periodic stellar variables are generally better described by a QPO than a DRW, while quasars are better described by the DRW model. There are ambiguities in interpreting the QPO coherence time due to non-sinusoidal light-curve shapes, signal-to-noise ratio, error mischaracterizations and cadence. Higher order implementations of the QPO model that better capture light-curve shapes are necessary for the coherence time to have its implied physical meaning. Independent of physical meaning, the extra parameter of the QPO model successfully distinguishes most of the classes of periodic and quasi-periodic variables we consider.

Water exchange on a geological timescale - examples from two coastal sites in the Baltic Sea.

PubMed

Eriksson, Christin; Engqvist, Anders

2013-05-01

The water turnover of two coastal areas, Forsmark and Laxemar-Simpevarp, has been modeled for 13 selected years between 6500 BC and 9000 AD by utilizing information about past, present, and future bathymetry. The Forsmark area can be described as an open-ended funnel, and is analyzed with a 3D-model (MIKE 3-FM); the Laxemar area is partitioned into clusters of sub-basins treated with a discrete coupled basin model (CouBa). In all simulations, the main variation factor is the land uplift. The 3D-model domain is successively modified. For the CouBa approach the successive basin configurations are objectively deduced based on the 3D domain modifications. The average age (AvA) of the resident water relative to the open coast is generally lower for the Forsmark area. A typical progression is that the AvA values increase until a sub-basin ceases to be connected to the coastal zone. This disconnection is often preceded by a lowered AvA.

Analysis of the impact of trap-neuter-return programs on populations of feral cats.

PubMed

Foley, Patrick; Foley, Janet E; Levy, Julie K; Paik, Terry

2005-12-01

To evaluate 2 county trap-neuter-return (TNR) programs for feral cat population management via mathematical modeling. Theoretical population model. Feral cats assessed from 1992 to 2003 in San Diego County, California (n = 14,452), and from 1998 to 2004 in Alachua County, Florida (11,822). Data were analyzed with a mathematical Ricker model to describe population dynamics of the feral cats and modifications to the dynamics that occurred as a result of the TNR programs. In both counties, results of analyses did not indicate a consistent reduction in per capita growth, the population multiplier, or the proportion of female cats that were pregnant. Success of feral cat management programs that use TNR can be monitored with an easily collected set of data and statistical analyses facilitated by population modeling techniques. Results may be used to suggest possible future monitoring and modification of TNR programs, which could result in greater success controlling and reducing feral cat populations.

Kinetic modeling of antimony(III) oxidation and sorption in soils.

PubMed

Cai, Yongbing; Mi, Yuting; Zhang, Hua

2016-10-05

Kinetic batch and saturated column experiments were performed to study the oxidation, adsorption and transport of Sb(III) in two soils with contrasting properties. Kinetic and column experiment results clearly demonstrated the extensive oxidation of Sb(III) in soils, and this can in return influence the adsorption and transport of Sb. Both sorption capacity and kinetic oxidation rate were much higher in calcareous Huanjiang soil than in acid red Yingtan soil. The results indicate that soil serve as a catalyst in promoting oxidation of Sb(III) even under anaerobic conditions. A PHREEQC model with kinetic formulations was developed to simulate the oxidation, sorption and transport of Sb(III) in soils. The model successfully described Sb(III) oxidation and sorption data in kinetic batch experiment. It was less successful in simulating the reactive transport of Sb(III) in soil columns. Additional processes such as colloid facilitated transport need to be quantified and considered in the model. Copyright © 2016 Elsevier B.V. All rights reserved.

Insights from the design and implementation of a single-entry model of referral for total joint replacement surgery: Critical success factors and unanticipated consequences.

PubMed

Damani, Zaheed; MacKean, Gail; Bohm, Eric; Noseworthy, Tom; Wang, Jenney Meng Han; DeMone, Brie; Wright, Brock; Marshall, Deborah A

2018-02-01

Single-entry models (SEMs) in healthcare allow patients to see the next-available provider and have been shown to improve waiting times, access and patient flow for preference-sensitive, scheduled services. The Winnipeg Central Intake Service (WCIS) for hip and knee replacement surgery was implemented to improve access in the Winnipeg Regional Health Authority. This paper describes the system's design/implementation; successes, challenges, and unanticipated consequences. On two occasions, during and following implementation, we interviewed all members of the WCIS project team, including processing engineers, waiting list coordinators, administrators and policy-makers regarding their experiences. We used semi-structured telephone interviews to collect data and qualitative thematic analysis to analyze and interpret the findings. Respondents indicated that the overarching objectives of the WCIS were being met. Benefits included streamlined processes, greater patient access, improved measurement and monitoring of outcomes. Challenges included low awareness, change readiness, and initial participation among stakeholders. Unanticipated consequences included workload increases, confusion around stakeholder expectations and under-reporting of data by surgeons' offices. Critical success factors for implementation included a requirement for clear communication, robust data collection, physician leadership and patience by all, especially implementation teams. Although successfully implemented, key lessons and critical success factors were learned related to change management, which if considered and applied, can reduce unanticipated consequences, improve uptake and benefit new models of care. Copyright © 2017 Elsevier B.V. All rights reserved.

Nuclear Forensics and Radiochemistry: Reaction Networks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rundberg, Robert S.

In the intense neutron flux of a nuclear explosion the production of isotopes may occur through successive neutron induced reactions. The pathway to these isotopes illustrates both the complexity of the problem and the need for high quality nuclear data. The growth and decay of radioactive isotopes can follow a similarly complex network. The Bateman equation will be described and modified to apply to the transmutation of isotopes in a high flux reactor. A alternative model of growth and decay, the GD code, that can be applied to fission products will also be described.

Analysis of Oscillatory Neural Activity in Series Network Models of Parkinson's Disease During Deep Brain Stimulation.

PubMed

Davidson, Clare M; de Paor, Annraoi M; Cagnan, Hayriye; Lowery, Madeleine M

2016-01-01

Parkinson's disease is a progressive, neurodegenerative disorder, characterized by hallmark motor symptoms. It is associated with pathological, oscillatory neural activity in the basal ganglia. Deep brain stimulation (DBS) is often successfully used to treat medically refractive Parkinson's disease. However, the selection of stimulation parameters is based on qualitative assessment of the patient, which can result in a lengthy tuning period and a suboptimal choice of parameters. This study explores fourth-order, control theory-based models of oscillatory activity in the basal ganglia. Describing function analysis is applied to examine possible mechanisms for the generation of oscillations in interacting nuclei and to investigate the suppression of oscillations with high-frequency stimulation. The theoretical results for the suppression of the oscillatory activity obtained using both the fourth-order model, and a previously described second-order model, are optimized to fit clinically recorded local field potential data obtained from Parkinsonian patients with implanted DBS. Close agreement between the power of oscillations recorded for a range of stimulation amplitudes is observed ( R(2)=0.69-0.99 ). The results suggest that the behavior of the system and the suppression of pathological neural oscillations with DBS is well described by the macroscopic models presented. The results also demonstrate that in this instance, a second-order model is sufficient to model the clinical data, without the need for added complexity. Describing the system behavior with computationally efficient models could aid in the identification of optimal stimulation parameters for patients in a clinical environment.

Recent Progress in Hepatocyte Culture Models and Their Application to the Assessment of Drug Metabolism, Transport, and Toxicity in Drug Discovery: The Value of Tissue Engineering for the Successful Development of a Microphysiological System.

PubMed

Tetsuka, Kazuhiro; Ohbuchi, Masato; Tabata, Kenji

2017-09-01

Tissue engineering technology has provided many useful culture models. This article reviews the merits of this technology in a hepatocyte culture system and describes the applications of the sandwich-cultured hepatocyte model in drug discovery. In addition, we also review recent investigations of the utility of the 3-dimensional bioprinted human liver tissue model and spheroid model. Finally, we present the future direction and developmental challenges of a hepatocyte culture model for the successful establishment of a microphysiological system, represented as an organ-on-a-chip and even as a human-on-a-chip. A merit of advanced culture models is their potential use for detecting hepatotoxicity through repeated exposure to chemicals as they allow long-term culture while maintaining hepatocyte functionality. As a future direction, such advanced hepatocyte culture systems can be connected to other tissue models for evaluating tissue-to-tissue interaction beyond cell-to-cell interaction. This combination of culture models could represent parts of the human body in a microphysiological system. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Use of program logic models in the Southern Rural Access Program evaluation.

PubMed

Pathman, Donald; Thaker, Samruddhi; Ricketts, Thomas C; Albright, Jennifer B

2003-01-01

The Southern Rural Access Program (SRAP) evaluation team used program logic models to clarify grantees' activities, objectives, and timelines. This information was used to benchmark data from grantees' progress reports to assess the program's successes. This article presents a brief background on the use of program logic models--essentially charts or diagrams specifying a program's planned activities, objectives, and goals--for evaluating and managing a program. It discusses the structure of the logic models chosen for the SRAP and how the model concept was introduced to the grantees to promote acceptance and use of the models. The article describes how the models helped clarify the program's objectives and helped lead agencies plan and manage the many program initiatives and subcontractors in their states. Models also provided a framework for grantees to report their progress to the National Program Office and evaluators and promoted the evaluators' visibility and acceptance by the grantees. Program logics, however, increased grantees' reporting requirements and demanded substantial time of the evaluators. Program logic models, on balance, proved their merit in the SRAP through their contributions to its management and evaluation and by providing a better understanding of the program's initiatives, successes, and potential impact.

Bayesian multimodel inference for dose-response studies

USGS Publications Warehouse

Link, W.A.; Albers, P.H.

2007-01-01

Statistical inference in dose?response studies is model-based: The analyst posits a mathematical model of the relation between exposure and response, estimates parameters of the model, and reports conclusions conditional on the model. Such analyses rarely include any accounting for the uncertainties associated with model selection. The Bayesian inferential system provides a convenient framework for model selection and multimodel inference. In this paper we briefly describe the Bayesian paradigm and Bayesian multimodel inference. We then present a family of models for multinomial dose?response data and apply Bayesian multimodel inferential methods to the analysis of data on the reproductive success of American kestrels (Falco sparveriuss) exposed to various sublethal dietary concentrations of methylmercury.

Engineering Functional Epithelium for Regenerative Medicine and In Vitro Organ Models: A Review

PubMed Central

Vrana, Nihal E.; Lavalle, Philippe; Dokmeci, Mehmet R.; Dehghani, Fariba; Ghaemmaghami, Amir M.

2013-01-01

Recent advances in the fields of microfabrication, biomaterials, and tissue engineering have provided new opportunities for developing biomimetic and functional tissues with potential applications in disease modeling, drug discovery, and replacing damaged tissues. An intact epithelium plays an indispensable role in the functionality of several organs such as the trachea, esophagus, and cornea. Furthermore, the integrity of the epithelial barrier and its degree of differentiation would define the level of success in tissue engineering of other organs such as the bladder and the skin. In this review, we focus on the challenges and requirements associated with engineering of epithelial layers in different tissues. Functional epithelial layers can be achieved by methods such as cell sheets, cell homing, and in situ epithelialization. However, for organs composed of several tissues, other important factors such as (1) in vivo epithelial cell migration, (2) multicell-type differentiation within the epithelium, and (3) epithelial cell interactions with the underlying mesenchymal cells should also be considered. Recent successful clinical trials in tissue engineering of the trachea have highlighted the importance of a functional epithelium for long-term success and survival of tissue replacements. Hence, using the trachea as a model tissue in clinical use, we describe the optimal structure of an artificial epithelium as well as challenges of obtaining a fully functional epithelium in macroscale. One of the possible remedies to address such challenges is the use of bottom-up fabrication methods to obtain a functional epithelium. Modular approaches for the generation of functional epithelial layers are reviewed and other emerging applications of microscale epithelial tissue models for studying epithelial/mesenchymal interactions in healthy and diseased (e.g., cancer) tissues are described. These models can elucidate the epithelial/mesenchymal tissue interactions at the microscale and provide the necessary tools for the next generation of multicellular engineered tissues and organ-on-a-chip systems. PMID:23705900

Engineering functional epithelium for regenerative medicine and in vitro organ models: a review.

PubMed

Vrana, Nihal E; Lavalle, Philippe; Dokmeci, Mehmet R; Dehghani, Fariba; Ghaemmaghami, Amir M; Khademhosseini, Ali

2013-12-01

Recent advances in the fields of microfabrication, biomaterials, and tissue engineering have provided new opportunities for developing biomimetic and functional tissues with potential applications in disease modeling, drug discovery, and replacing damaged tissues. An intact epithelium plays an indispensable role in the functionality of several organs such as the trachea, esophagus, and cornea. Furthermore, the integrity of the epithelial barrier and its degree of differentiation would define the level of success in tissue engineering of other organs such as the bladder and the skin. In this review, we focus on the challenges and requirements associated with engineering of epithelial layers in different tissues. Functional epithelial layers can be achieved by methods such as cell sheets, cell homing, and in situ epithelialization. However, for organs composed of several tissues, other important factors such as (1) in vivo epithelial cell migration, (2) multicell-type differentiation within the epithelium, and (3) epithelial cell interactions with the underlying mesenchymal cells should also be considered. Recent successful clinical trials in tissue engineering of the trachea have highlighted the importance of a functional epithelium for long-term success and survival of tissue replacements. Hence, using the trachea as a model tissue in clinical use, we describe the optimal structure of an artificial epithelium as well as challenges of obtaining a fully functional epithelium in macroscale. One of the possible remedies to address such challenges is the use of bottom-up fabrication methods to obtain a functional epithelium. Modular approaches for the generation of functional epithelial layers are reviewed and other emerging applications of microscale epithelial tissue models for studying epithelial/mesenchymal interactions in healthy and diseased (e.g., cancer) tissues are described. These models can elucidate the epithelial/mesenchymal tissue interactions at the microscale and provide the necessary tools for the next generation of multicellular engineered tissues and organ-on-a-chip systems.

The effects of integrating service learning into computer science: an inter-institutional longitudinal study

NASA Astrophysics Data System (ADS)

Payton, Jamie; Barnes, Tiffany; Buch, Kim; Rorrer, Audrey; Zuo, Huifang

2015-07-01

This study is a follow-up to one published in computer science education in 2010 that reported preliminary results showing a positive impact of service learning on student attitudes associated with success and retention in computer science. That paper described how service learning was incorporated into a computer science course in the context of the Students & Technology in Academia, Research, and Service (STARS) Alliance, an NSF-supported broadening participation in computing initiative that aims to diversify the computer science pipeline through innovative pedagogy and inter-institutional partnerships. The current paper describes how the STARS Alliance has expanded to diverse institutions, all using service learning as a vehicle for broadening participation in computing and enhancing attitudes and behaviors associated with student success. Results supported the STARS model of service learning for enhancing computing efficacy and computing commitment and for providing diverse students with many personal and professional development benefits.

A Mass Balance for Mercury in the San Francisco Bay Area

PubMed Central

MacLeod, Matthew; McKone, Thomas E.; Mackay, Don

2008-01-01

We develop and illustrate a general regional multi-species model that describes the fate and transport of mercury in three forms, elemental, divalent, and methylated, in a generic regional environment including air, soil, vegetation, water and sediment. The objectives of the model are to describes the fate of the three forms of mercury in the environment and determine the dominant physical sinks that remove mercury from the system. Chemical transformations between the three groups of mercury species are modeled by assuming constant ratios of species concentrations in individual environmental media. We illustrate and evaluate the model with an application to describe the fate and transport of mercury in the San Francisco Bay Area of California. The model successfully rationalizes the identified sources with observed concentrations of total mercury and methyl mercury in the San Francisco Bay Estuary. The mass balance provided by the model indicates that continental and global background sources control mercury concentrations in the atmosphere but loadings to water in the San Francisco Bay estuary are dominated by runoff from the Central Valley catchment and re-mobilization of contaminated sediments deposited during past mining activities. The model suggests that the response time of mercury concentrations in the San Francisco Bay estuary to changes in loadings is long, of the order of 50 years. PMID:16190232

A physiologically based kinetic model for bacterial sulfide oxidation.

PubMed

Klok, Johannes B M; de Graaff, Marco; van den Bosch, Pim L F; Boelee, Nadine C; Keesman, Karel J; Janssen, Albert J H

2013-02-01

In the biotechnological process for hydrogen sulfide removal from gas streams, a variety of oxidation products can be formed. Under natron-alkaline conditions, sulfide is oxidized by haloalkaliphilic sulfide oxidizing bacteria via flavocytochrome c oxidoreductase. From previous studies, it was concluded that the oxidation-reduction state of cytochrome c is a direct measure for the bacterial end-product formation. Given this physiological feature, incorporation of the oxidation state of cytochrome c in a mathematical model for the bacterial oxidation kinetics will yield a physiologically based model structure. This paper presents a physiologically based model, describing the dynamic formation of the various end-products in the biodesulfurization process. It consists of three elements: 1) Michaelis-Menten kinetics combined with 2) a cytochrome c driven mechanism describing 3) the rate determining enzymes of the respiratory system of haloalkaliphilic sulfide oxidizing bacteria. The proposed model is successfully validated against independent data obtained from biological respiration tests and bench scale gas-lift reactor experiments. The results demonstrate that the model is a powerful tool to describe product formation for haloalkaliphilic biomass under dynamic conditions. The model predicts a maximum S⁰ formation of about 98 mol%. A future challenge is the optimization of this bioprocess by improving the dissolved oxygen control strategy and reactor design. Copyright © 2012 Elsevier Ltd. All rights reserved.

Ringing phenomenon in coupled cavities: Application to modal coupling in whispering-gallery-mode resonators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trebaol, Stephane; Dumeige, Yannick; Feron, Patrice

We present a simple model to describe the transient response of two coupled resonators probed by a monochromatic wave whose frequency is rapidly swept across the resonances with respect to their characteristic photon lifetimes. The model is applied to analyze the dynamic behavior of the modal coupling between two degenerate resonances of the same cavity. In particular, this can be used to describe the coupling of counterpropagating whispering gallery modes (WGMs) by Rayleigh scattering. The theory is successfully compared to experiments carried out in silica microspheres. These results show that this ringdown technique can be extended to accurately measure linearmore » properties and frequency splittings of high-quality factor WGM microresonators.« less

Scheduling Earth Observing Fleets Using Evolutionary Algorithms: Problem Description and Approach

NASA Technical Reports Server (NTRS)

Globus, Al; Crawford, James; Lohn, Jason; Morris, Robert; Clancy, Daniel (Technical Monitor)

2002-01-01

We describe work in progress concerning multi-instrument, multi-satellite scheduling. Most, although not all, Earth observing instruments currently in orbit are unique. In the relatively near future, however, we expect to see fleets of Earth observing spacecraft, many carrying nearly identical instruments. This presents a substantially new scheduling challenge. Inspired by successful commercial applications of evolutionary algorithms in scheduling domains, this paper presents work in progress regarding the use of evolutionary algorithms to solve a set of Earth observing related model problems. Both the model problems and the software are described. Since the larger problems will require substantial computation and evolutionary algorithms are embarrassingly parallel, we discuss our parallelization techniques using dedicated and cycle-scavenged workstations.

The combination of simulation and response methodology and its application in an aggregate production plan

NASA Astrophysics Data System (ADS)

Chen, Zhiming; Feng, Yuncheng

1988-08-01

This paper describes an algorithmic structure for combining simulation and optimization techniques both in theory and practice. Response surface methodology is used to optimize the decision variables in the simulation environment. A simulation-optimization software has been developed and successfully implemented, and its application to an aggregate production planning simulation-optimization model is reported. The model's objective is to minimize the production cost and to generate an optimal production plan and inventory control strategy for an aircraft factory.

Follow-on proposal identifying environmental features for land management decisions

NASA Technical Reports Server (NTRS)

Wright, P. M.; Ridd, M. K.

1986-01-01

Urban morphology (an examination of spatial fabric and structure), natural ecosystem (investigations emphasizing biophysical processes and patterns), and human ecosystem (emphasizing socio-economic and engineering parameters) were studied. The most critical variable, transpiration, in the ASPCON model, created by Jaynes (1978), describing the hydrology of aspen to conifer succession was studied to improve the accuracy. Transpiration is determined by a canopy transpiration model which estimates consumptive water use (CWU) for specific species and a plant activity index. Also studied was Pinyon-Juniper woodland erosion.

Interplanetary propagation of flare-associated energetic particles

NASA Technical Reports Server (NTRS)

Masung, L. L.; Earl, J. A.

1978-01-01

A propagation model which combines a Gaussian profile for particle release from the sun, with interplanetary particle densities predicted by focused diffusion, was proposed to explain the propagation history of flare associated energetic particles. This model, which depends on only two parameters, successfully describes the time-intensity profiles of 30 proton and electron events originating from the western hemisphere of the sun. Generally, particles are released from the sun over a finite interval. In almost all events, particle release begins at the time of flare acceleration.

Preventing skin cancer through behavior change. Implications for interventions.

PubMed

Rossi, J S; Blais, L M; Redding, C A; Weinstock, M A

1995-07-01

Sun exposure is the only major causative factor for skin cancer for which prevention is feasible. Both individual and community-based interventions have been effective in changing sun exposure knowledge and attitudes but generally have not been effective in changing behaviors. An integrative model of behavior change is described that has been successful in changing behavior across a wide range of health conditions. This model holds promise for developing a rational public health approach to skin cancer prevention based on sound behavioral science.

Systematic review of the influence of foraging habitat on red-cockaded woodpecker reproductive success.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garabedian, James E.

Relationships between foraging habitat and reproductive success provide compelling evidence of the contribution of specific vegetative features to foraging habitat quality, a potentially limiting factor for many animal populations. For example, foraging habitat quality likely will gain importance in the recovery of the threatened red-cockaded woodpecker Picoides borealis (RCW) in the USA as immediate nesting constraints are mitigated. Several researchers have characterized resource selection by foraging RCWs, but emerging research linking reproductive success (e.g. clutch size, nestling and fledgling production, and group size) and foraging habitat features has yet to be synthesized. Therefore, we reviewed peer-refereed scientific literature and technicalmore » resources (e.g. books, symposia proceedings, and technical reports) that examined RCW foraging ecology, foraging habitat, or demography to evaluate evidence for effects of the key foraging habitat features described in the species’ recovery plan on group reproductive success. Fitness-based habitat models suggest foraging habitat with low to intermediate pine Pinus spp. densities, presence of large and old pines, minimal midstory development, and herbaceous groundcover support more productive RCW groups. However, the relationships between some foraging habitat features and RCW reproductive success are not well supported by empirical data. In addition, few regression models account for > 30% of variation in reproductive success, and unstandardized multiple and simple linear regression coefficient estimates typically range from -0.100 to 0.100, suggesting ancillary variables and perhaps indirect mechanisms influence reproductive success. These findings suggest additional research is needed to address uncertainty in relationships between foraging habitat features and RCW reproductive success and in the mechanisms underlying those relationships.« less

Fluctuating Nonlinear Spring Model of Mechanical Deformation of Biological Particles

PubMed Central

Kononova, Olga; Snijder, Joost; Kholodov, Yaroslav; Marx, Kenneth A.; Wuite, Gijs J. L.; Roos, Wouter H.; Barsegov, Valeri

2016-01-01

The mechanical properties of virus capsids correlate with local conformational dynamics in the capsid structure. They also reflect the required stability needed to withstand high internal pressures generated upon genome loading and contribute to the success of important events in viral infectivity, such as capsid maturation, genome uncoating and receptor binding. The mechanical properties of biological nanoparticles are often determined from monitoring their dynamic deformations in Atomic Force Microscopy nanoindentation experiments; but a comprehensive theory describing the full range of observed deformation behaviors has not previously been described. We present a new theory for modeling dynamic deformations of biological nanoparticles, which considers the non-linear Hertzian deformation, resulting from an indenter-particle physical contact, and the bending of curved elements (beams) modeling the particle structure. The beams’ deformation beyond the critical point triggers a dynamic transition of the particle to the collapsed state. This extreme event is accompanied by a catastrophic force drop as observed in the experimental or simulated force (F)-deformation (X) spectra. The theory interprets fine features of the spectra, including the nonlinear components of the FX-curves, in terms of the Young’s moduli for Hertzian and bending deformations, and the structural damage dependent beams’ survival probability, in terms of the maximum strength and the cooperativity parameter. The theory is exemplified by successfully describing the deformation dynamics of natural nanoparticles through comparing theoretical curves with experimental force-deformation spectra for several virus particles. This approach provides a comprehensive description of the dynamic structural transitions in biological and artificial nanoparticles, which is essential for their optimal use in nanotechnology and nanomedicine applications. PMID:26821264

A physiology-based model describing heterogeneity in glucose metabolism: the core of the Eindhoven Diabetes Education Simulator (E-DES).

PubMed

Maas, Anne H; Rozendaal, Yvonne J W; van Pul, Carola; Hilbers, Peter A J; Cottaar, Ward J; Haak, Harm R; van Riel, Natal A W

2015-03-01

Current diabetes education methods are costly, time-consuming, and do not actively engage the patient. Here, we describe the development and verification of the physiological model for healthy subjects that forms the basis of the Eindhoven Diabetes Education Simulator (E-DES). E-DES shall provide diabetes patients with an individualized virtual practice environment incorporating the main factors that influence glycemic control: food, exercise, and medication. The physiological model consists of 4 compartments for which the inflow and outflow of glucose and insulin are calculated using 6 nonlinear coupled differential equations and 14 parameters. These parameters are estimated on 12 sets of oral glucose tolerance test (OGTT) data (226 healthy subjects) obtained from literature. The resulting parameter set is verified on 8 separate literature OGTT data sets (229 subjects). The model is considered verified if 95% of the glucose data points lie within an acceptance range of ±20% of the corresponding model value. All glucose data points of the verification data sets lie within the predefined acceptance range. Physiological processes represented in the model include insulin resistance and β-cell function. Adjusting the corresponding parameters allows to describe heterogeneity in the data and shows the capabilities of this model for individualization. We have verified the physiological model of the E-DES for healthy subjects. Heterogeneity of the data has successfully been modeled by adjusting the 4 parameters describing insulin resistance and β-cell function. Our model will form the basis of a simulator providing individualized education on glucose control. © 2014 Diabetes Technology Society.

Three Collaborative Models for Scaling Up Evidence-Based Practices

PubMed Central

Roberts, Rosemarie; Jones, Helen; Marsenich, Lynne; Sosna, Todd; Price, Joseph M.

2015-01-01

The current paper describes three models of research-practice collaboration to scale-up evidence-based practices (EBP): (1) the Rolling Cohort model in England, (2) the Cascading Dissemination model in San Diego County, and (3) the Community Development Team model in 53 California and Ohio counties. Multidimensional Treatment Foster Care (MTFC) and KEEP are the focal evidence-based practices that are designed to improve outcomes for children and families in the child welfare, juvenile justice, and mental health systems. The three scale-up models each originated from collaboration between community partners and researchers with the shared goal of wide-spread implementation and sustainability of MTFC/KEEP. The three models were implemented in a variety of contexts; Rolling Cohort was implemented nationally, Cascading Dissemination was implemented within one county, and Community Development Team was targeted at the state level. The current paper presents an overview of the development of each model, the policy frameworks in which they are embedded, system challenges encountered during scale-up, and lessons learned. Common elements of successful scale-up efforts, barriers to success, factors relating to enduring practice relationships, and future research directions are discussed. PMID:21484449

Unique Practice, Unique Place: Exploring Two Assertive Community Treatment Teams in Maine.

PubMed

Schroeder, Rebecca A

2018-06-01

Assertive Community Treatment (ACT) is a model of care that provides comprehensive community-based psychiatric care for persons with serious mental illness. This model has been widely documented and has shown to be an evidence-based model of care for reducing hospitalizations for this targeted population. Critical ingredients of the ACT model are the holistic nature of their services, a team based approach to treatment and nurses who assist with illness management, medication monitoring, and provider collaboration. Although the model remains strong there are clear differences between urban and rural teams. This article describes present day practice in two disparate ACT programs in urban and rural Maine. It offers a new perspective on the evolving and innovative program of services that treat those with serious mental illness along with a review of literature pertinent to the ACT model and future recommendations for nursing practice. The success and longevity of these two ACT programs are testament to the quality of care and commitment of staff that work with seriously mentally ill consumers. Integrative care models such as these community-based treatment teams and nursing driven interventions are prime elements of this successful model.

A poroelastic model describing nutrient transport and cell stresses within a cyclically strained collagen hydrogel.

PubMed

Vaughan, Benjamin L; Galie, Peter A; Stegemann, Jan P; Grotberg, James B

2013-11-05

In the creation of engineered tissue constructs, the successful transport of nutrients and oxygen to the contained cells is a significant challenge. In highly porous scaffolds subject to cyclic strain, the mechanical deformations can induce substantial fluid pressure gradients, which affect the transport of solutes. In this article, we describe a poroelastic model to predict the solid and fluid mechanics of a highly porous hydrogel subject to cyclic strain. The model was validated by matching the predicted penetration of a bead into the hydrogel from the model with experimental observations and provides insight into nutrient transport. Additionally, the model provides estimates of the wall-shear stresses experienced by the cells embedded within the scaffold. These results provide insight into the mechanics of and convective nutrient transport within a cyclically strained hydrogel, which could lead to the improved design of engineered tissues. Copyright © 2013 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Modified parton branching model for multi-particle production in hadronic collisions: Application to SUSY particle branching

NASA Astrophysics Data System (ADS)

Yuanyuan, Zhang

The stochastic branching model of multi-particle productions in high energy collision has theoretical basis in perturbative QCD, and also successfully describes the experimental data for a wide energy range. However, over the years, little attention has been put on the branching model for supersymmetric (SUSY) particles. In this thesis, a stochastic branching model has been built to describe the pure supersymmetric particle jets evolution. This model is a modified two-phase stochastic branching process, or more precisely a two phase Simple Birth Process plus Poisson Process. The general case that the jets contain both ordinary particle jets and supersymmetric particle jets has also been investigated. We get the multiplicity distribution of the general case, which contains a Hypergeometric function in its expression. We apply this new multiplicity distribution to the current experimental data of pp collision at center of mass energy √s = 0.9, 2.36, 7 TeV. The fitting shows the supersymmetric particles haven't participate branching at current collision energy.

Development of a Training Model for Laparoscopic Common Bile Duct Exploration

PubMed Central

Rodríguez, Omaira; Benítez, Gustavo; Sánchez, Renata; De la Fuente, Liliana

2010-01-01

Background: Training and experience of the surgical team are fundamental for the safety and success of complex surgical procedures, such as laparoscopic common bile duct exploration. Methods: We describe an inert, simple, very low-cost, and readily available training model. Created using a “black box” and basic medical and surgical material, it allows training in the fundamental steps necessary for laparoscopic biliary tract surgery, namely, (1) intraoperative cholangiography, (2) transcystic exploration, and (3) laparoscopic choledochotomy, and t-tube insertion. Results: The proposed model has allowed for the development of the skills necessary for partaking in said procedures, contributing to its development and diminishing surgery time as the trainee advances down the learning curve. Further studies are directed towards objectively determining the impact of the model on skill acquisition. Conclusion: The described model is simple and readily available allowing for accurate reproduction of the main steps and maneuvers that take place during laparoscopic common bile duct exploration, with the purpose of reducing failure and complications. PMID:20529526

The Viareggio LPG railway accident: event reconstruction and modeling.

PubMed

Brambilla, Sara; Manca, Davide

2010-10-15

This manuscript describes in detail the LPG accident occurred in Viareggio on June 2009 and its modeling. The accident investigation highlighted the uncertainty and complexity of assessing and modeling what happened in the congested environment close to the Viareggio railway station. Nonetheless, the analysis allowed comprehending the sequence of events, the way they influenced each other, and the different possible paths/evolutions. The paper describes suitable models for the quantitative assessment of the consequences of the most probable accidental dynamics and its outcomes. The main finding is that after about 80 s from the beginning of the release the dense-gas cloud reached the surrounding houses that were destroyed successively by internal explosions. This fact has two main implications. First, it shows that the adopted modeling framework can give a correct picture of what happened in Viareggio. Second, it confirms the need to develop effective mitigation measures because, in case of this kind of accidents, there is no time to apply any protective emergency plans/actions. 2010 Elsevier B.V. All rights reserved.

Preliminary Study of 2-D Time Domain Electromagnetic (TDEM) Modeling to Analyze Subsurface Resistivity Distribution and its Application to the Geothermal Systems

NASA Astrophysics Data System (ADS)

Aji Hapsoro, Cahyo; Purqon, Acep; Srigutomo, Wahyu

2017-07-01

2-D Time Domain Electromagnetic (TDEM) has been successfully conducted to illustrate the value of Electric field distribution under the Earth surface. Electric field compared by magnetic field is used to analyze resistivity and resistivity is one of physical properties which very important to determine the reservoir potential area of geothermal systems as one of renewable energy. In this modeling we used Time Domain Electromagnetic method because it can solve EM field interaction problem with complex geometry and to analyze transient problems. TDEM methods used to model the value of electric and magnetic fields as a function of the time combined with the function of distance and depth. The result of this modeling is Electric field intensity value which is capable to describe the structure of the Earth’s subsurface. The result of this modeling can be applied to describe the Earths subsurface resistivity values to determine the reservoir potential of geothermal systems.

Design and fabrication of robotic gripper for grasping in minimizing contact force

NASA Astrophysics Data System (ADS)

Heidari, Hamidreza; Pouria, Milad Jafary; Sharifi, Shahriar; Karami, Mahmoudreza

2018-03-01

This paper presents a new method to improve the kinematics of robot gripper for grasping in unstructured environments, such as space operations. The robot gripper is inspired from the human hand and kept the hand design close to the structure of human fingers to provide successful grasping capabilities. The main goal is to improve kinematic structure of gripper to increase the grasping capability of large objects, decrease the contact forces and makes a successful grasp of various objects in unstructured environments. This research will describe the development of a self-adaptive and reconfigurable robotic hand for space operations through mechanical compliance which is versatile, robust and easy to control. Our model contains two fingers, two-link and three-link, with combining a kinematic model of thumb index. Moreover, some experimental tests are performed to examine the effectiveness of the hand-made in real, unstructured tasks. The results represent that the successful grasp range is improved about 30% and the contact forces is reduced approximately 10% for a wide range of target object size. According to the obtained results, the proposed approach provides an accommodative kinematic model which makes the better grasping capability by fingers geometries for a robot gripper.

Visualization of the variability of 3D statistical shape models by animation.

PubMed

Lamecker, Hans; Seebass, Martin; Lange, Thomas; Hege, Hans-Christian; Deuflhard, Peter

2004-01-01

Models of the 3D shape of anatomical objects and the knowledge about their statistical variability are of great benefit in many computer assisted medical applications like images analysis, therapy or surgery planning. Statistical model of shapes have successfully been applied to automate the task of image segmentation. The generation of 3D statistical shape models requires the identification of corresponding points on two shapes. This remains a difficult problem, especially for shapes of complicated topology. In order to interpret and validate variations encoded in a statistical shape model, visual inspection is of great importance. This work describes the generation and interpretation of statistical shape models of the liver and the pelvic bone.

Use of a business excellence model to improve conservation programs.

PubMed

Black, Simon; Groombridge, Jim

2010-12-01

The current shortfall in effectiveness within conservation biology is illustrated by increasing interest in "evidence-based conservation," whose proponents have identified the need to benchmark conservation initiatives against actions that lead to proven positive effects. The effectiveness of conservation policies, approaches, and evaluation is under increasing scrutiny, and in these areas models of excellence used in business could prove valuable. Typically, conservation programs require years of effort and involve rigorous long-term implementation processes. Successful balance of long-term efforts alongside the achievement of short-term goals is often compromised by management or budgetary constraints, a situation also common in commercial businesses. "Business excellence" is an approach many companies have used over the past 20 years to ensure continued success. Various business excellence evaluations have been promoted that include concepts that could be adapted and applied in conservation programs. We describe a conservation excellence model that shows how scientific processes and results can be aligned with financial and organizational measures of success. We applied the model to two well-documented species conservation programs. In the first, the Po'ouli program, several aspects of improvement were identified, such as more authority for decision making in the field and better integration of habitat management and population recovery processes. The second example, the black-footed ferret program, could have benefited from leadership effort to reduce bureaucracy and to encourage use of best-practice species recovery approaches. The conservation excellence model enables greater clarity in goal setting, more-effective identification of job roles within programs, better links between technical approaches and measures of biological success, and more-effective use of resources. The model could improve evaluation of a conservation program's effectiveness and may be used to compare different programs, for example during reviews of project performance by sponsoring organizations. © 2010 Society for Conservation Biology.

Protein docking by the interface structure similarity: how much structure is needed?

PubMed

Sinha, Rohita; Kundrotas, Petras J; Vakser, Ilya A

2012-01-01

The increasing availability of co-crystallized protein-protein complexes provides an opportunity to use template-based modeling for protein-protein docking. Structure alignment techniques are useful in detection of remote target-template similarities. The size of the structure involved in the alignment is important for the success in modeling. This paper describes a systematic large-scale study to find the optimal definition/size of the interfaces for the structure alignment-based docking applications. The results showed that structural areas corresponding to the cutoff values <12 Å across the interface inadequately represent structural details of the interfaces. With the increase of the cutoff beyond 12 Å, the success rate for the benchmark set of 99 protein complexes, did not increase significantly for higher accuracy models, and decreased for lower-accuracy models. The 12 Å cutoff was optimal in our interface alignment-based docking, and a likely best choice for the large-scale (e.g., on the scale of the entire genome) applications to protein interaction networks. The results provide guidelines for the docking approaches, including high-throughput applications to modeled structures.

Mathematical problems in the application of multilinear models to facial emotion processing experiments

NASA Astrophysics Data System (ADS)

Andersen, Anders H.; Rayens, William S.; Li, Ren-Cang; Blonder, Lee X.

2000-10-01

In this paper we describe the enormous potential that multilinear models hold for the analysis of data from neuroimaging experiments that rely on functional magnetic resonance imaging (MRI) or other imaging modalities. A case is made for why one might fully expect that the successful introduction of these models to the neuroscience community could define the next generation of structure-seeking paradigms in the area. In spite of the potential for immediate application, there is much to do from the perspective of statistical science. That is, although multilinear models have already been particularly successful in chemistry and psychology, relatively little is known about their statistical properties. To that end, our research group at the University of Kentucky has made significant progress. In particular, we are in the process of developing formal influence measures for multilinear methods as well as associated classification models and effective implementations. We believe that these problems will be among the most important and useful to the scientific community. Details are presented herein and an application is given in the context of facial emotion processing experiments.

Trend analysis of vegetation in Louisiana's Atchafalaya river basin

USGS Publications Warehouse

O'Neil, Calvin P.; deSteiguer, J. Edward; North, Gary W.

1978-01-01

The purpose of the study was to determine vegetation succession trends; produce a current vegetation map of the basin; and to develop a mathematical model capable of predicting vegetation changes based on hydrologic factors. A statistical relationship of forests and hydrological variables with forest succession constraints predicted forest acreage totals for 16 forest categories within 70% or better of actual values in two-thirds of the cases. Using time-lapsed photography covering 42 years, 23 categories were described. The succession trend of vegetation since 1930, by sedimentation, had been toward mixed hardwoods, except for isolated areas. Satellite MSS Band 7 imagery was used to map the current vegetation into three main categories and for assessment of acreage. Additionally, a geological anomaly was recognized on satellite imagery indication an effect on drainage and sedimentation.

Quantitative and empirical demonstration of the Matthew effect in a study of career longevity

PubMed Central

Petersen, Alexander M.; Jung, Woo-Sung; Yang, Jae-Suk; Stanley, H. Eugene

2011-01-01

The Matthew effect refers to the adage written some two-thousand years ago in the Gospel of St. Matthew: “For to all those who have, more will be given.” Even two millennia later, this idiom is used by sociologists to qualitatively describe the dynamics of individual progress and the interplay between status and reward. Quantitative studies of professional careers are traditionally limited by the difficulty in measuring progress and the lack of data on individual careers. However, in some professions, there are well-defined metrics that quantify career longevity, success, and prowess, which together contribute to the overall success rating for an individual employee. Here we demonstrate testable evidence of the age-old Matthew “rich get richer” effect, wherein the longevity and past success of an individual lead to a cumulative advantage in further developing his or her career. We develop an exactly solvable stochastic career progress model that quantitatively incorporates the Matthew effect and validate our model predictions for several competitive professions. We test our model on the careers of 400,000 scientists using data from six high-impact journals and further confirm our findings by testing the model on the careers of more than 20,000 athletes in four sports leagues. Our model highlights the importance of early career development, showing that many careers are stunted by the relative disadvantage associated with inexperience. PMID:21173276

Landscape anthropogenic disturbance in the Mediterranean ecosystem: is the current landscape sustainable?

NASA Astrophysics Data System (ADS)

Biondi, Guido; D'Andrea, Mirko; Fiorucci, Paolo; Franciosi, Chiara; Lima, Marco

2013-04-01

Mediterranean landscape during the last centuries has been subject to strong anthropogenic disturbances who shifted natural vegetation cover in a cultural landscape. Most of the natural forest were destroyed in order to allow cultivation and grazing activities. In the last century, fast growing conifer plantations were introduced in order to increase timber production replacing slow growing natural forests. In addition, after the Second World War most of the grazing areas were changed in unmanaged mediterranean conifer forest frequently spread by fires. In the last decades radical socio economic changes lead to a dramatic abandonment of the cultural landscape. One of the most relevant result of these human disturbances, and in particular the replacement of deciduous forests with coniferous forests, has been the increasing in the number of forest fires, mainly human caused. The presence of conifers and shrubs, more prone to fire, triggered a feedback mechanism that makes difficult to return to the stage of potential vegetation causing huge economic, social and environmental damages. The aim of this work is to investigate the sustainability of the current landscape. A future landscape scenario has been simulated considering the natural succession in absence of human intervention assuming the current fire regime will be unaltered. To this end, a new model has been defined, implementing an ecological succession model coupled with a simply Forest Fire Model. The ecological succession model simulates the vegetation dynamics using a rule-based approach discrete in space and time. In this model Plant Functional Types (PFTs) are used to describe the landscape. Wildfires are randomly ignited on the landscape, and their propagation is simulated using a stochastic cellular automata model. The results show that the success of the natural succession toward a potential vegetation cover is prevented by the frequency of fire spreading. The actual landscape is then unsustainable because of the high cost of fire fighting activities. The right path to success consists in development of suitable land use planning and forest management to mitigate the consequences of past anthropogenic disturbances.

Program Development from Start-to-Finish: A Case Study of the Healthy Relationship and Marriage Education Training Project

ERIC Educational Resources Information Center

Futris, Ted G.; Schramm, David G.

2015-01-01

What goes into designing and implementing a successful program? How do both research and practice inform program development? In this article, the process through which a federally funded training curriculum was developed and piloted tested is described. Using a logic model framework, important lessons learned are shared in defining the situation,…

Mobilizing Rural Community Resources for Support and Development of Local Learning Systems in Developing Countries.

ERIC Educational Resources Information Center

O'Grady, Barbara, Ed.; Levenson, Ruth, Ed.

Focusing on how local village communities in developing countries might support part or all of their educational costs, this study describes methods used by developing countries to reduce education costs and offers a model incorporating several of the most successful components of such projects. First is a discussion of methods used by governments…

Developing the next generation of nurse scientists.

PubMed

Burkhart, Patricia V; Hall, Lynne A

2015-01-01

This article describes an undergraduate nursing research internship program in which students are engaged in research with a faculty mentor. Since 2002, more than 130 undergraduate nursing students have participated. Interns coauthored publications, presented papers and posters at conferences, and received awards. This highly successful program provides a model that can be easily replicated to foster the development of future nurse scientists.

Building a Path to College Success: Advocacy, Discovery and OER Adoption in Emerging Educational Models

ERIC Educational Resources Information Center

Woodward, Kristin M.

2017-01-01

In this case study we will examine the role of the library in Open Educational Resources through the lens of library value described in Megan Oakleaf's 2010 ACRL [Association of College and Research Libraries] report. While librarians in our organization have traditionally not played a role in textbook adoptions, the campus academic goal to…

Using the R2D2 Model for Creating Collaboration among Practicing Teachers and Preservice Teachers during Reading Assessment Preparation at Four Universities

ERIC Educational Resources Information Center

Merkley, Donna; Duffelmeyer, Frederick; Beed, Penny; Jensen, Sharon; Bobys, Aileen

2007-01-01

It is essential that preservice teachers have successful experiences with infused technology during teacher preparation. This article describes a project in which collegial interaction among practicing teachers and preservice teachers at four participating institutions of higher education was enhanced by technological innovation. The Recursive,…

A Special Section on International Education--What We Can Learn from Russia's Schools

ERIC Educational Resources Information Center

Post, Becky

2005-01-01

Russia's educational system has been successful in producing graduates who excel in mathematics, the sciences, and foreign languages, but these are not the only areas that we might look to as models. Russian and American cultures and educational practices differ in significant ways, and not all of the practices described here would be workable in…

Inclusion in the Workforce for Students with Intellectual Disabilities: A Case Study of a Spanish Postsecondary Education Program

ERIC Educational Resources Information Center

Judge, Sharon; Gasset, Dolores Izuzquiza

2015-01-01

The Autonomous University of Madrid (UAM) is the first Spanish university to provide training to young people with intellectual disabilities (ID) in the university environment, which qualifies them for inclusion in the workforce. In this practice brief we describe the UAM-Prodis Patronage Chair program, a successful model used at Spanish…

Model Programs for Retaining and Promoting Minorities and Women and Increasing Minority Student Retention and Success.

ERIC Educational Resources Information Center

Kappner, Augusta Souza; And Others

Efforts undertaken to meet the challenge of diversity at the City University of New York's Borough of Manhattan Community College (BMCC) are described in this five-part conference presentation. In the first part, BMCC's president, Augusta Souza Kappner, provides an overview of the ethnic and demographic composition of the college's student body…

The Path to Pedagogical Reform in the Sciences: Engaging Mutual Adaptation and Social Movement Models of Change

ERIC Educational Resources Information Center

Kezar, Adrianna

2012-01-01

One of the dilemmas that policy makers, campus leaders, and individual faculty members often describe with chagrin is the difficulty of scaling up successful innovations. Officials at the National Science Foundation (NSF), for example, admit they are discouraged because the results of most NSF-funded projects are not disseminated beyond the target…

Smocks and Jocks outside the Box: The Paradigmatic Evolution of Sport and Exercise Psychology

ERIC Educational Resources Information Center

Vealey, Robin S.

2006-01-01

The objective of this article is to describe the historical development of sport and exercise psychology, with a particular emphasis on the construction and evolution of the "box" through history. The box represents the dominant paradigm that serves as the model for research and application as it evolves through successive historical eras (Kuhn,…

Stages of Headship: A Longitudinal Study of the Principalship.

ERIC Educational Resources Information Center

Weindling, Dick

This paper uses socialization theory to re-examine a unique, 10-year longitudinal study of headteachers so as to describe the stages of headship transition. It outlines prior models of leadership succession in both business and schools and produces a stage theory of headship that can be used not only as a research tool, but also as a way to assist…

The Challenge of Differing Perspectives Surrounding Grades in the Assessment Education of Pre-Service Teachers

ERIC Educational Resources Information Center

Mitton-Kukner, Jennifer; Munroe, Elizabeth; Graham, Deborah

2015-01-01

In this paper we describe the challenges we experience teaching an assessment course to pre-service teachers, as part of their studies in a bachelor of education program. As we teach the course, our intent is to explicitly model assessment practices that reflect a philosophy of "success for all," rather than "sort and rank."…

MVP and College Success for First-Year Students

ERIC Educational Resources Information Center

Becker, Karen A.

2017-01-01

This chapter describes a Reading and Study Skills program and course that are offered to first-year students who are underprepared or reluctant and who may be at risk for failure in other courses as well as at risk for long-term retention and graduation. The course is discussed with respect to its parallels to the MVP model, and initial evidence…

A receptor-based model for dopamine-induced fMRI signal

PubMed Central

Mandeville, Joseph. B.; Sander, Christin Y. M.; Jenkins, Bruce G.; Hooker, Jacob M.; Catana, Ciprian; Vanduffel, Wim; Alpert, Nathaniel M.; Rosen, Bruce R.; Normandin, Marc D.

2013-01-01

This report describes a multi-receptor physiological model of the fMRI temporal response and signal magnitude evoked by drugs that elevate synaptic dopamine in basal ganglia. The model is formulated as a summation of dopamine’s effects at D1-like and D2-like receptor families, which produce functional excitation and inhibition, respectively, as measured by molecular indicators like adenylate cyclase or neuroimaging techniques like fMRI. Functional effects within the model are described in terms of relative changes in receptor occupancies scaled by receptor densities and neuro-vascular coupling constants. Using literature parameters, the model reconciles many discrepant observations and interpretations of pre-clinical data. Additionally, we present data showing that amphetamine stimulation produces fMRI inhibition at low doses and a biphasic response at higher doses in the basal ganglia of non-human primates (NHP), in agreement with model predictions based upon the respective levels of evoked dopamine. Because information about dopamine release is required to inform the fMRI model, we simultaneously acquired PET 11C-raclopride data in several studies to evaluate the relationship between raclopride displacement and assumptions about dopamine release. At high levels of dopamine release, results suggest that refinements of the model will be required to consistently describe the PET and fMRI data. Overall, the remarkable success of the model in describing a wide range of preclinical fMRI data indicate that this approach will be useful for guiding the design and analysis of basic science and clinical investigations and for interpreting the functional consequences of dopaminergic stimulation in normal subjects and in populations with dopaminergic neuroadaptations. PMID:23466936

The transformation from custodial to recovery-oriented care: a paradigm shift that needed to happen.

PubMed

McKenna, Brian; Furness, Trentham; Dhital, Deepa; Park, Malcolm; Connally, Fiona

2014-01-01

As custodial mental health services are beginning to adopt a recovery-oriented model of care, it is imperative that successes in the transformation to recovery are captured. The aim of this illustrative case study was to describe the organizational procedure that enabled the systematic transformation of a custodial mental health service to a service with a self-professed recovery orientation as its model of service delivery. One-to-one interviews with key stakeholders and a document analysis were completed to thoroughly describe the transformation of the service. Four major themes arose from the data: (a) "We had this whole paradigm shift that needed to happen;" (b) "Think recovery," the development of a manualized guide; (c) "Stepping out my recovery;" adaptation of the service guide to the secure care context; and (d) developing the culture. The "developing the culture" major theme was subcategorized to consist of (a) the right people, (b) education, (c) reflective learning, and (d) leadership. The themes provided insights to assist mental health nurses to understand the processes involved in systems transformation. However, the major successes of the service, although only recently evaluated, commenced over a decade ago and yet continue to evolve.

Working With Socially and Medically Complex Patients: When Care Transitions Are Circular, Overlapping, and Continual Rather Than Linear and Finite.

PubMed

Roberts, Shauna R; Crigler, Jane; Ramirez, Cristina; Sisco, Deborah; Early, Gerald L

2015-01-01

The care coordination program described here evolved from 5 years of trial and learning related to how to best serve our high-cost, high-utilizing, chronically ill, urban core patient population. In addition to medical complexity, they have daily challenges characteristic of persons served by Safety-Net health systems. Many have unstable health insurance status. Others have insecure housing. A number of patients have a history of substance use and mental illness. Many have fractured social supports. Although some of the best-known care transition models have been successful in reducing rehospitalizations and cost among patients studied, these models were developed for a relatively high functioning patient population with social support. We describe a successful approach targeted at working with patients who require a more intense and lengthy care coordination intervention to self-manage and reduce the cost of caring for their medical conditions. Using a diverse team and a set of replicable processes, we have demonstrated statistically significant reduction in the use of hospital and emergency services. Our intervention leverages the strengths and resilience of patients, focuses on trust and self-management, and targets heterogeneous "high-utilizer" patients with medical and social complexity.

Establishment of sequential software processing for a biomechanical model of mandibular reconstruction with custom-made plate.

PubMed

Li, Peng; Tang, Youchao; Li, Jia; Shen, Longduo; Tian, Weidong; Tang, Wei

2013-09-01

The aim of this study is to describe the sequential software processing of computed tomography (CT) dataset for reconstructing the finite element analysis (FEA) mandibular model with custom-made plate, and to provide a theoretical basis for clinical usage of this reconstruction method. A CT scan was done on one patient who had mandibular continuity defects. This CT dataset in DICOM format was imported into Mimics 10.0 software in which a three-dimensional (3-D) model of the facial skeleton was reconstructed and the mandible was segmented out. With Geomagic Studio 11.0, one custom-made plate and nine virtual screws were designed. All parts of the reconstructed mandible were converted into NURBS and saved as IGES format for importing into pro/E 4.0. After Boolean operation and assembly, the model was switched to ANSYS Workbench 12.0. Finally, after applying the boundary conditions and material properties, an analysis was performed. As results, a 3-D FEA model was successfully developed using the softwares above. The stress-strain distribution precisely indicated biomechanical performance of the reconstructed mandible on the normal occlusion load, without stress concentrated areas. The Von-Mises stress in all parts of the model, from the maximum value of 50.9MPa to the minimum value of 0.1MPa, was lower than the ultimate tensile strength. In conclusion, the described strategy could speedily and successfully produce a biomechanical model of a reconstructed mandible with custom-made plate. Using this FEA foundation, the custom-made plate may be improved for an optimal clinical outcome. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development

PubMed Central

Han, Seunghoon; Jeon, Sangil; Hong, Taegon; Lee, Jongtae; Bae, Soo Hyeon; Park, Wan-su; Park, Gab-jin; Youn, Sunil; Jang, Doo Yeon; Kim, Kyung-Soo; Yim, Dong-Seok

2015-01-01

No wholly successful weight-control drugs have been developed to date, despite the tremendous demand. We present an exposure–response model of sibutramine mesylate that can be applied during clinical development of other weight-control drugs. Additionally, we provide a model-based evaluation of sibutramine efficacy. Data from a double-blind, randomized, placebo-controlled, multicenter study were used (N=120). Subjects in the treatment arm were initially given 8.37 mg sibutramine base daily, and those who lost <2 kg after 4 weeks’ treatment were escalated to 12.55 mg. The duration of treatment was 24 weeks. Drug concentration and body weight were measured predose and at 4 weeks, 8 weeks, and 24 weeks after treatment initiation. Exposure and response to sibutramine, including the placebo effect, were modeled using NONMEM 7.2. An asymptotic model approaching the final body weight was chosen to describe the time course of weight loss. Extent of weight loss was described successfully using a sigmoidal exposure–response relationship of the drug with a constant placebo effect in each individual. The placebo effect was influenced by subjects’ sex and baseline body mass index. Maximal weight loss was predicted to occur around 1 year after treatment initiation. The difference in mean weight loss between the sibutramine (daily 12.55 mg) and placebo groups was predicted to be 4.5% in a simulation of 1 year of treatment, with considerable overlap of prediction intervals. Our exposure–response model, which included the placebo effect, is the first example of a quantitative model that can be used to predict the efficacy of weight-control drugs. Similar approaches can help decision-making during clinical development of novel weight-loss drugs. PMID:26392753

Exposure-response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development.

PubMed

Han, Seunghoon; Jeon, Sangil; Hong, Taegon; Lee, Jongtae; Bae, Soo Hyeon; Park, Wan-su; Park, Gab-jin; Youn, Sunil; Jang, Doo Yeon; Kim, Kyung-Soo; Yim, Dong-Seok

2015-01-01

No wholly successful weight-control drugs have been developed to date, despite the tremendous demand. We present an exposure-response model of sibutramine mesylate that can be applied during clinical development of other weight-control drugs. Additionally, we provide a model-based evaluation of sibutramine efficacy. Data from a double-blind, randomized, placebo-controlled, multicenter study were used (N=120). Subjects in the treatment arm were initially given 8.37 mg sibutramine base daily, and those who lost <2 kg after 4 weeks' treatment were escalated to 12.55 mg. The duration of treatment was 24 weeks. Drug concentration and body weight were measured predose and at 4 weeks, 8 weeks, and 24 weeks after treatment initiation. Exposure and response to sibutramine, including the placebo effect, were modeled using NONMEM 7.2. An asymptotic model approaching the final body weight was chosen to describe the time course of weight loss. Extent of weight loss was described successfully using a sigmoidal exposure-response relationship of the drug with a constant placebo effect in each individual. The placebo effect was influenced by subjects' sex and baseline body mass index. Maximal weight loss was predicted to occur around 1 year after treatment initiation. The difference in mean weight loss between the sibutramine (daily 12.55 mg) and placebo groups was predicted to be 4.5% in a simulation of 1 year of treatment, with considerable overlap of prediction intervals. Our exposure-response model, which included the placebo effect, is the first example of a quantitative model that can be used to predict the efficacy of weight-control drugs. Similar approaches can help decision-making during clinical development of novel weight-loss drugs.

Implementing effective and sustainable multidisciplinary clinical thoracic oncology programs

PubMed Central

Freeman, Richard K.; Krasna, Mark J.

2015-01-01

Three models of care are described, including two models of multidisciplinary care for thoracic malignancies. The pros and cons of each model are discussed, the evidence supporting each is reviewed, and the need for more (and better) research into care delivery models is highlighted. Key stakeholders in thoracic oncology care delivery outcomes are identified, and the need to consider stakeholder perspectives in designing, validating and implementing multidisciplinary programs as a vehicle for quality improvement in thoracic oncology is emphasized. The importance of reconciling stakeholder perspectives, and identify meaningful stakeholder-relevant benchmarks is also emphasized. Metrics for measuring program implementation and overall success are proposed. PMID:26380186

Implementing effective and sustainable multidisciplinary clinical thoracic oncology programs.

PubMed

Osarogiagbon, Raymond U; Freeman, Richard K; Krasna, Mark J

2015-08-01

Three models of care are described, including two models of multidisciplinary care for thoracic malignancies. The pros and cons of each model are discussed, the evidence supporting each is reviewed, and the need for more (and better) research into care delivery models is highlighted. Key stakeholders in thoracic oncology care delivery outcomes are identified, and the need to consider stakeholder perspectives in designing, validating and implementing multidisciplinary programs as a vehicle for quality improvement in thoracic oncology is emphasized. The importance of reconciling stakeholder perspectives, and identify meaningful stakeholder-relevant benchmarks is also emphasized. Metrics for measuring program implementation and overall success are proposed.

An approach to adjustment of relativistic mean field model parameters

NASA Astrophysics Data System (ADS)

Bayram, Tuncay; Akkoyun, Serkan

2017-09-01

The Relativistic Mean Field (RMF) model with a small number of adjusted parameters is powerful tool for correct predictions of various ground-state nuclear properties of nuclei. Its success for describing nuclear properties of nuclei is directly related with adjustment of its parameters by using experimental data. In the present study, the Artificial Neural Network (ANN) method which mimics brain functionality has been employed for improvement of the RMF model parameters. In particular, the understanding capability of the ANN method for relations between the RMF model parameters and their predictions for binding energies (BEs) of 58Ni and 208Pb have been found in agreement with the literature values.

Parameter Estimation for Viscoplastic Material Modeling

NASA Technical Reports Server (NTRS)

Saleeb, Atef F.; Gendy, Atef S.; Wilt, Thomas E.

1997-01-01

A key ingredient in the design of engineering components and structures under general thermomechanical loading is the use of mathematical constitutive models (e.g. in finite element analysis) capable of accurate representation of short and long term stress/deformation responses. In addition to the ever-increasing complexity of recent viscoplastic models of this type, they often also require a large number of material constants to describe a host of (anticipated) physical phenomena and complicated deformation mechanisms. In turn, the experimental characterization of these material parameters constitutes the major factor in the successful and effective utilization of any given constitutive model; i.e., the problem of constitutive parameter estimation from experimental measurements.

A business model analysis of telecardiology service.

PubMed

Lin, Shu-Hsia; Liu, Jorn-Hon; Wei, Jen; Yin, Wei-Hsian; Chen, Hung-Hsin; Chiu, Wen-Ta

2010-12-01

Telecare has become an increasingly common medical service in recent years. However, new service must be close to the market and be market-driven to have a high likelihood of success. This article analyzes the business model of a telecardiology service managed by a general hospital. The methodology of the article is as follows: (1) initially it describes the elements of the service based on the ontology of the business model, (2) then it transfers these elements into the choices for business model dynamic loops and examines their validity, and (3) finally provides an empirical financial analysis of the service to assess the profit-making possibilities.

The birth of a collaborative model: obstetricians, midwives, and family physicians.

PubMed

Pecci, Christine Chang; Mottl-Santiago, Julie; Culpepper, Larry; Heffner, Linda; McMahan, Therese; Lee-Parritz, Aviva

2012-09-01

In the United States, the challenges of maternity care include provider workforce, cost containment, and equal access to quality care. This article describes a collaborative model of care involving midwives, family physicians, and obstetricians at the Boston Medical Center, which serves a low-income multicultural population. Leadership investment in a collaborative model of care from the Department of Obstetrics and Gynecology, Section of Midwifery, and the Department of Family Medicine created a culture of safety and commitment to patient-centered care. Essential elements of the authors' successful model include a commitment to excellence in patient care, communication, and interdisciplinary education. Copyright © 2012 Elsevier Inc. All rights reserved.

Optical potentials for nuclear level structures and nucleon interactions data of tin isotopes based on the soft-rotator model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Jeong-Yeon; Hahn, Insik; Kim, Yeongduk

2009-06-15

The soft-rotator model is applied to self-consistent analyses of the nuclear level structures and the nucleon interaction data of the even-even Sn isotopes, {sup 116}Sn, {sup 118}Sn, {sup 120}Sn, and {sup 122}Sn. The model successfully describes low-lying collective levels of these isotopes, which exhibit neither typical rotational nor harmonic vibrational structures. The experimental nucleon interaction data--total neutron cross sections, proton reaction cross sections, and nucleon elastic and inelastic scattering data--are well described up to 200 MeV in a coupled-channels optical model approach. For the calculations, nuclear wave functions for the Sn isotopes are taken from the nonaxial soft-rotator model withmore » the model parameters adjusted to fit the measured low-lying collective level structures. We find that the {beta}{sub 2} and {beta}{sub 3} deformations for incident protons are larger than those for incident neutrons by {approx}15%, which is clear evidence of the deviation from the pure collective model for these isotopes.« less

Effort to Accelerate MBSE Adoption and Usage at JSC

NASA Technical Reports Server (NTRS)

Wang, Lui; Izygon, Michel; Okron, Shira; Garner, Larry; Wagner, Howard

2016-01-01

This paper describes the authors' experience in adopting Model Based System Engineering (MBSE) at the NASA/Johnson Space Center (JSC). Since 2009, NASA/JSC has been applying MBSE using the Systems Modeling Language (SysML) to a number of advanced projects. Models integrate views of the system from multiple perspectives, capturing the system design information for multiple stakeholders. This method has allowed engineers to better control changes, improve traceability from requirements to design and manage the numerous interactions between components. As the project progresses, the models become the official source of information and used by multiple stakeholders. Three major types of challenges that hamper the adoption of the MBSE technology are described. These challenges are addressed by a multipronged approach that includes educating the main stakeholders, implementing an organizational infrastructure that supports the adoption effort, defining a set of modeling guidelines to help engineers in their modeling effort, providing a toolset that support the generation of valuable products, and providing a library of reusable models. JSC project case studies are presented to illustrate how the proposed approach has been successfully applied.

A dissolution model that accounts for coverage of mineral surfaces by precipitation in core floods

NASA Astrophysics Data System (ADS)

Pedersen, Janne; Jettestuen, Espen; Madland, Merete V.; Hildebrand-Habel, Tania; Korsnes, Reidar I.; Vinningland, Jan Ludvig; Hiorth, Aksel

2016-01-01

In this paper, we propose a model for evolution of reactive surface area of minerals due to surface coverage by precipitating minerals. The model is used to interpret results from an experiment where a chalk core was flooded with MgCl2 for 1072 days, giving rise to calcite dissolution and magnesite precipitation. The model successfully describes both the long-term behavior of the measured effluent concentrations and the more or less homogeneous distribution of magnesite found in the core after 1072 days. The model also predicts that precipitating magnesite minerals form as larger crystals or aggregates of smaller size crystals, and not as thin flakes or as a monomolecular layer. Using rate constants obtained from literature gave numerical effluent concentrations that diverged from observed values only after a few days of flooding. To match the simulations to the experimental data after approximately 1 year of flooding, a rate constant that is four orders of magnitude lower than reported by powder experiments had to be used. We argue that a static rate constant is not sufficient to describe a chalk core flooding experiment lasting for nearly 3 years. The model is a necessary extension of standard rate equations in order to describe long term core flooding experiments where there is a large degree of textural alteration.

Modeling Bird Migration under Climate Change: A Mechanistic Approach

NASA Technical Reports Server (NTRS)

Smith, James A.

2009-01-01

How will migrating birds respond to changes in the environment under climate change? What are the implications for migratory success under the various accelerated climate change scenarios as forecast by the Intergovernmental Panel on Climate Change? How will reductions or increased variability in the number or quality of wetland stop-over sites affect migratory bird species? The answers to these questions have important ramifications for conservation biology and wildlife management. Here, we describe the use of continental scale simulation modeling to explore how spatio-temporal changes along migratory flyways affect en-route migration success. We use an individually based, biophysical, mechanistic, bird migration model to simulate the movement of shorebirds in North America as a tool to study how such factors as drought and wetland loss may impact migratory success and modify migration patterns. Our model is driven by remote sensing and climate data and incorporates important landscape variables. The energy budget components of the model include resting, foraging, and flight, but presently predation is ignored. Results/Conclusions We illustrate our model by studying the spring migration of sandpipers through the Great Plains to their Arctic breeding grounds. Why many species of shorebirds have shown significant declines remains a puzzle. Shorebirds are sensitive to stop-over quality and spacing because of their need for frequent refueling stops and their opportunistic feeding patterns. We predict bird "hydrographs that is, stop-over frequency with latitude, that are in agreement with the literature. Mean stop-over durations predicted from our model for nominal cases also are consistent with the limited, but available data. For the shorebird species simulated, our model predicts that shorebirds exhibit significant plasticity and are able to shift their migration patterns in response to changing drought conditions. However, the question remains as to whether this behavior can be maintained over increasing and sustained environmental change. Also, the problem is much more complex than described by the current processes captured in our model. We have taken some important and interesting steps, and our model does demonstrate how local scale information about individual stop-over sites can be linked into the migratory flyway as a whole. We are incorporating additional, species specific, mechanistic processes to better reflect different climate change scenarios

30 cm Engineering Model thruster design and qualification tests

NASA Technical Reports Server (NTRS)

Schnelker, D. E.; Collett, C. R.

1975-01-01

Development of a 30-cm mercury electron bombardment Engineering Model ion thruster has successfully brought the thruster from the status of a laboratory experimental device to a point approaching flight readiness. This paper describes the development progress of the Engineering Model (EM) thruster in four areas: (1) design features and fabrication approaches, (2) performance verification and thruster to thruster variations, (3) structural integrity, and (4) interface definition. The design of major subassemblies, including the cathode-isolator-vaporizer (CIV), main isolator-vaporizer (MIV), neutralizer isolator-vaporizer (NIV), ion optical system, and discharge chamber/outer housing is discussed along with experimental results.

An Investigation of the Compatibility of Radiation and Convection Heat Flux Measurements

NASA Technical Reports Server (NTRS)

Liebert, Curt H.

1996-01-01

A method for determining time-resolved absorbed surface heat flux and surface temperature in radiation and convection environments is described. The method is useful for verification of aerodynamic, heat transfer and durability models. A practical heat flux gage fabrication procedure and a simple one-dimensional inverse heat conduction model and calculation procedure are incorporated in this method. The model provides an estimate of the temperature and heat flux gradient in the direction of heat transfer through the gage. This paper discusses several successful time-resolved tests of this method in hostile convective heating and cooling environments.

Development of an apparatus to measure thermophysical properties of wind tunnel heat transfer models

NASA Technical Reports Server (NTRS)

Romanowski, R. F.; Steinberg, I. H.

1974-01-01

The apparatus and technique for measuring the thermophysical properties of models used with the phase-change paint method for obtaining wind tunnel heat transfer data are described. The method allows rapid measurement of the combined properties in a transient manner similar to an actual wind tunnel test. An effective value of the thermophysical properties can be determined which accounts for changes in thermal properties with temperature or with depth into the model surface. The apparatus was successfully tested at various heating rates between 19,000 and 124,000 watts per square meter.

Sustainability in Biobanking: Model of Biobank Graz.

PubMed

Sargsyan, Karine; Macheiner, Tanja; Story, Petra; Strahlhofer-Augsten, Manuela; Plattner, Katharina; Riegler, Skaiste; Granitz, Gabriele; Bayer, Michaela; Huppertz, Berthold

2015-12-01

Research infrastructures remain the key for state-of-the-art and successful research. In the last few decades, biobanks have become increasingly important in this field through standardization of biospecimen processing, sample storage, and standardized data management. Research infrastructure in cohort studies and other sample collection activities are currently experiencing a lack of long-term funding. In this article, the Biobank Graz discusses these aspects of sustainability including the definition of sustainability and necessity of a business plan, as well as cost calculation model in the field of biobanking. The economic state, critical success factors, and important operational issues are reviewed and described by the authors, using the example of the Biobank Graz. Sustainability in the field of biobanking is a globally important matter of necessity, starting from policy making and ending with security and documentation on each operational level.

Twelve tips for implementing whole-task curricula: how to make it work.

PubMed

Dolmans, Diana H J M; Wolfhagen, Ineke H A P; Van Merriënboer, Jeroen J G

2013-10-01

Whole-task models of learning and instructional design, such as problem-based learning, are nowadays very popular. Schools regularly encounter large problems when they implement whole-task curricula. The main aim of this article is to provide 12 tips that may help to make the implementation of a whole-task curriculum successful. Implementing whole-task curricula fails when the implementation is not well prepared. Requirements that must be met to make the implementation of whole task models into a success are described as twelve tips. The tips are organized in four clusters and refer to (1) the infrastructure, (2) the teachers, (3) the students, and (4) the management of the educational organization. Finally, the presented framework will be critically discussed and the importance of shared values and a change of culture is emphasized.

Numerical Modeling in Geodynamics: Success, Failure and Perspective

NASA Astrophysics Data System (ADS)

Ismail-Zadeh, A.

2005-12-01

A real success in numerical modeling of dynamics of the Earth can be achieved only by multidisciplinary research teams of experts in geodynamics, applied and pure mathematics, and computer science. The success in numerical modeling is based on the following basic, but simple, rules. (i) People need simplicity most, but they understand intricacies best (B. Pasternak, writer). Start from a simple numerical model, which describes basic physical laws by a set of mathematical equations, and move then to a complex model. Never start from a complex model, because you cannot understand the contribution of each term of the equations to the modeled geophysical phenomenon. (ii) Study the numerical methods behind your computer code. Otherwise it becomes difficult to distinguish true and erroneous solutions to the geodynamic problem, especially when your problem is complex enough. (iii) Test your model versus analytical and asymptotic solutions, simple 2D and 3D model examples. Develop benchmark analysis of different numerical codes and compare numerical results with laboratory experiments. Remember that the numerical tool you employ is not perfect, and there are small bugs in every computer code. Therefore the testing is the most important part of your numerical modeling. (iv) Prove (if possible) or learn relevant statements concerning the existence, uniqueness and stability of the solution to the mathematical and discrete problems. Otherwise you can solve an improperly-posed problem, and the results of the modeling will be far from the true solution of your model problem. (v) Try to analyze numerical models of a geological phenomenon using as less as possible tuning model variables. Already two tuning variables give enough possibilities to constrain your model well enough with respect to observations. The data fitting sometimes is quite attractive and can take you far from a principal aim of your numerical modeling: to understand geophysical phenomena. (vi) If the number of tuning model variables are greater than two, test carefully the effect of each of the variables on the modeled phenomenon. Remember: With four exponents I can fit an elephant (E. Fermi, physicist). (vii) Make your numerical model as accurate as possible, but never put the aim to reach a great accuracy: Undue precision of computations is the first symptom of mathematical illiteracy (N. Krylov, mathematician). How complex should be a numerical model? A model which images any detail of the reality is as useful as a map of scale 1:1 (J. Robinson, economist). This message is quite important for geoscientists, who study numerical models of complex geodynamical processes. I believe that geoscientists will never create a model of the real Earth dynamics, but we should try to model the dynamics such a way to simulate basic geophysical processes and phenomena. Does a particular model have a predictive power? Each numerical model has a predictive power, otherwise the model is useless. The predictability of the model varies with its complexity. Remember that a solution to the numerical model is an approximate solution to the equations, which have been chosen in believe that they describe dynamic processes of the Earth. Hence a numerical model predicts dynamics of the Earth as well as the mathematical equations describe this dynamics. What methodological advances are still needed for testable geodynamic modeling? Inverse (time-reverse) numerical modeling and data assimilation are new methodologies in geodynamics. The inverse modeling can allow to test geodynamic models forward in time using restored (from present-day observations) initial conditions instead of unknown conditions.

Describing litho-constrained layout by a high-resolution model filter

NASA Astrophysics Data System (ADS)

Tsai, Min-Chun

2008-05-01

A novel high-resolution model (HRM) filtering technique was proposed to describe litho-constrained layouts. Litho-constrained layouts are layouts that have difficulties to pattern or are highly sensitive to process-fluctuations under current lithography technologies. HRM applies a short-wavelength (or high NA) model simulation directly on the pre-OPC, original design layout to filter out low spatial-frequency regions, and retain high spatial-frequency components which are litho-constrained. Since no OPC neither mask-synthesis steps are involved, this new technique is highly efficient in run time and can be used in design stage to detect and fix litho-constrained patterns. This method has successfully captured all the hot-spots with less than 15% overshoots on a realistic 80 mm2 full-chip M1 layout in 65nm technology node. A step by step derivation of this HRM technique is presented in this paper.

Photo screening around the world: Lions Club International Foundation experience.

PubMed

Donahue, Sean P; Lorenz, Sylvia; Johnson, Tammy

2008-01-01

To describe the use of photoscreening for preschool vision screening in several diverse locations throughout the world. The MTI photo screener was used to screen pre-verbal children; photographs were interpreted using standard criteria. The Tennessee vision screening program remains successful, screening over 200,000 children during the past 8 years. Similar programs modeled across the United States have screened an additional 500,000 children. A pilot demonstration project in Hong Kong, Beijing, and Brazil screened over 5000 additional children with good success and appropriately low referral rates. Photoscreening can be an appropriate technique for widespread vision screening of preschool children throughout the world.

ALVA: A Successful Program for Increasing the Number of Minority Undergraduates who Earn Engineering Degrees

PubMed Central

Peterson, Lisa; Pinkham, Scott; Jordan, Cathryne

2010-01-01

A highly successful minority outreach and support program for incoming college freshmen in engineering is described. The University of Washington has been running ALVA (Alliances for Learning and Vision for underrepresented Americans) for 11 years and continuously tracks its participants. Partners in ALVA come from the government, education, and industry. This program targets talented underrepresented minority students and addresses four major hurdles that face minority students in engineering: lack of vision of themselves as an engineer, finances, community, and academic preparation. We will present ALVA as a model that can be duplicated at other colleges and universities. PMID:25242894

Quantitative model for the blood pressure-lowering interaction of valsartan and amlodipine.

PubMed

Heo, Young-A; Holford, Nick; Kim, Yukyung; Son, Mijeong; Park, Kyungsoo

2016-12-01

The objective of this study was to develop a population pharmacokinetic (PK) and pharmacodynamic (PD) model to quantitatively describe the antihypertensive effect of combined therapy with amlodipine and valsartan. PK modelling was used with data collected from 48 healthy volunteers receiving a single dose of combined formulation of 10 mg amlodipine and 160 mg valsartan. Systolic (SBP) and diastolic blood pressure (DBP) were recorded during combined administration. SBP and DBP data for each drug alone were gathered from the literature. PKPD models of each drug and for combined administration were built with NONMEM 7.3. A two-compartment model with zero order absorption best described the PK data of both drugs. Amlodipine and valsartan monotherapy effects on SBP and DBP were best described by an I max model with an effect compartment delay. Combined therapy was described using a proportional interaction term as follows: (D 1  + D 2 ) +ALPHA×(D 1 × D 2 ). D 1 and D 2 are the predicted drug effects of amlodipine and valsartan monotherapy respectively. ALPHA is the interaction term for combined therapy. Quantitative estimates of ALPHA were -0.171 (95% CI: -0.218, -0.143) for SBP and -0.0312 (95% CI: -0.07739, -0.00283) for DBP. These infra-additive interaction terms for both SBP and DBP were consistent with literature results for combined administration of drugs in these classes. PKPD models for SBP and DBP successfully described the time course of the antihypertensive effects of amlodipine and valsartan. An infra-additive interaction between amlodipine and valsartan when used in combined administration was confirmed and quantified. © 2016 The British Pharmacological Society.

Quantitative model for the blood pressure‐lowering interaction of valsartan and amlodipine

PubMed Central

Heo, Young‐A; Holford, Nick; Kim, Yukyung; Son, Mijeong

2016-01-01

Aims The objective of this study was to develop a population pharmacokinetic (PK) and pharmacodynamic (PD) model to quantitatively describe the antihypertensive effect of combined therapy with amlodipine and valsartan. Methods PK modelling was used with data collected from 48 healthy volunteers receiving a single dose of combined formulation of 10 mg amlodipine and 160 mg valsartan. Systolic (SBP) and diastolic blood pressure (DBP) were recorded during combined administration. SBP and DBP data for each drug alone were gathered from the literature. PKPD models of each drug and for combined administration were built with NONMEM 7.3. Results A two‐compartment model with zero order absorption best described the PK data of both drugs. Amlodipine and valsartan monotherapy effects on SBP and DBP were best described by an I max model with an effect compartment delay. Combined therapy was described using a proportional interaction term as follows: (D1 + D2) +ALPHA×(D1 × D2). D1 and D2 are the predicted drug effects of amlodipine and valsartan monotherapy respectively. ALPHA is the interaction term for combined therapy. Quantitative estimates of ALPHA were −0.171 (95% CI: −0.218, −0.143) for SBP and −0.0312 (95% CI: −0.07739, −0.00283) for DBP. These infra‐additive interaction terms for both SBP and DBP were consistent with literature results for combined administration of drugs in these classes. Conclusion PKPD models for SBP and DBP successfully described the time course of the antihypertensive effects of amlodipine and valsartan. An infra‐additive interaction between amlodipine and valsartan when used in combined administration was confirmed and quantified. PMID:27504853

Kinetic Model of Growth of Arthropoda Populations

NASA Astrophysics Data System (ADS)

Ershov, Yu. A.; Kuznetsov, M. A.

2018-05-01

Kinetic equations were derived for calculating the growth of crustacean populations ( Crustacea) based on the biological growth model suggested earlier using shrimp ( Caridea) populations as an example. The development cycle of successive stages for populations can be represented in the form of quasi-chemical equations. The kinetic equations that describe the development cycle of crustaceans allow quantitative prediction of the development of populations depending on conditions. In contrast to extrapolation-simulation models, in the developed kinetic model of biological growth the kinetic parameters are the experimental characteristics of population growth. Verification and parametric identification of the developed model on the basis of the experimental data showed agreement with experiment within the error of the measurement technique.

Qualitative evaluation and economic estimates of an infection control champions program.

PubMed

Lloyd-Smith, Elisa; Curtin, Jim; Gilbart, Wayne; Romney, Marc G

2014-12-01

In many North American hospitals, conventional infection control operational models often struggle to provide sufficient support to frontline health care workers. The objective of this study was to describe a sustainable infection control champion (ICC) program based on findings from focus groups. A distributed model of infection control was established by placing infection prevention and control-trained ICCs in 3 Canadian hospitals for a period of 12 months. Subsequently, semistructured focus groups were conducted to describe overall feasibility and impeding and critical factors affecting sustainability. An economic estimate of the ICC program compared with the cost of hiring a new infection control practitioner was also calculated. Focus group participants considered the program feasible. Barriers included lack of time and staff turnover. Themes critical for the successful implementation of an ICC program included defined ICC roles and goals, adequate support and resources for the ICC, engagement with all levels of staff, flexible structure, and program evaluation. The cost per bed of the ICC program was less than the cost per bed of hiring a new infection control practitioner. A distributed model of providing infection prevention and control services may have benefit when hospital infection control teams are underresourced, as is often the case. Several key factors are needed for the successful implementation of an ICC program. Copyright © 2014 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Modeling of Electrochemical Process for the Treatment of Wastewater Containing Organic Pollutants

NASA Astrophysics Data System (ADS)

Rodrigo, Manuel A.; Cañizares, Pablo; Lobato, Justo; Sáez, Cristina

Electrocoagulation and electrooxidation are promising electrochemical technologies that can be used to remove organic pollutants contained in wastewaters. To make these technologies competitive with the conventional technologies that are in use today, a better understanding of the processes involved must be achieved. In this context, the development of mathematical models that are consistent with the processes occurring in a physical system is a relevant advance, because such models can help to understand what is happening in the treatment process. In turn, a more detailed knowledge of the physical system can be obtained, and tools for a proper design of the processes, or for the analysis of operating problems, are attained. The modeling of these technologies can be carried out using single-variable or multivariable models. Likewise, the position dependence of the model species can be described with different approaches. In this work, a review of the basics of the modeling of these processes and a description of several representative models for electrochemical oxidation and coagulation are carried out. Regarding electrooxidation, two models are described: one which summarizes the pollution of a wastewater in only one model species and that considers a macroscopic approach to formulate the mass balances and other that considers more detailed profile of concentration to describe the time course of pollutants and intermediates through a mixed maximum gradient/macroscopic approach. On the topic of electrochemical coagulation, two different approaches are also described in this work: one that considers the hydrodynamic conditions as the main factor responsible for the electrochemical coagulation processes and the other that considers the chemical interaction of the reagents and the pollutants as the more significant processes in the description of the electrochemical coagulation of organic compounds. In addition, in this work it is also described a multivariable model for the electrodissolution of anodes (first stage in electrocoagulation processes). This later model use a mixed macroscopic/maximum gradient approach to describe the chemical and electrochemical processes and it also assumes that the rates of all processes are very high, and that they can be successfully modeled using pseudoequilibrium approaches.

A study of metal ion adsorption at low suspended-solid concentrations

USGS Publications Warehouse

Chang, Cecily C.Y.; Davis, J.A.; Kuwabara, J.S.

1987-01-01

A procedure for conducting adsorption studies at low suspended solid concentrations in natural waters (<50 mg l-1) is described. Methodological complications previously associated with such experiments have been overcome. Adsorption of zinc ion onto synthetic colloidal titania (TiO2) was studied as a function of pH, supporting electrolyte (NaCl) concentration (0??1-0??002 m) and particle concentration (2-50 mg l-1). The lack of success of the Davis Leckie site bonding model in describing Zn(II) adsorption emphasizes the need for further studies of adsorption at low suspended-solid concentrations. ?? 1987.

Specific learning disability in mathematics: a comprehensive review.

PubMed

Soares, Neelkamal; Evans, Teresa; Patel, Dilip R

2018-01-01

Math skills are necessary for success in the childhood educational and future adult work environment. This article reviews the changing terminology for specific learning disabilities (SLD) in math and describes the emerging genetics and neuroimaging studies that relate to individuals with math disability (MD). It is important to maintain a developmental perspective on MD, as presentation changes with age, instruction, and the different models (educational and medical) of identification. Intervention requires a systematic approach to screening and remediation that has evolved with more evidence-based literature. Newer directions in behavioral, educational and novel interventions are described.

Specific learning disability in mathematics: a comprehensive review

PubMed Central

Evans, Teresa; Patel, Dilip R.

2018-01-01

Math skills are necessary for success in the childhood educational and future adult work environment. This article reviews the changing terminology for specific learning disabilities (SLD) in math and describes the emerging genetics and neuroimaging studies that relate to individuals with math disability (MD). It is important to maintain a developmental perspective on MD, as presentation changes with age, instruction, and the different models (educational and medical) of identification. Intervention requires a systematic approach to screening and remediation that has evolved with more evidence-based literature. Newer directions in behavioral, educational and novel interventions are described. PMID:29441282

Fast multilevel radiative transfer

NASA Astrophysics Data System (ADS)

Paletou, Frédéric; Léger, Ludovick

2007-01-01

The vast majority of recent advances in the field of numerical radiative transfer relies on approximate operator methods better known in astrophysics as Accelerated Lambda-Iteration (ALI). A superior class of iterative schemes, in term of rates of convergence, such as Gauss-Seidel and Successive Overrelaxation methods were therefore quite naturally introduced in the field of radiative transfer by Trujillo Bueno & Fabiani Bendicho (1995); it was thoroughly described for the non-LTE two-level atom case. We describe hereafter in details how such methods can be generalized when dealing with non-LTE unpolarised radiation transfer with multilevel atomic models, in monodimensional geometry.

Material wealth in 3D: Mapping multiple paths to prosperity in low- and middle- income countries.

PubMed

Hruschka, Daniel J; Hadley, Craig; Hackman, Joseph

2017-01-01

Material wealth is a key factor shaping human development and well-being. Every year, hundreds of studies in social science and policy fields assess material wealth in low- and middle-income countries assuming that there is a single dimension by which households can move from poverty to prosperity. However, a one-dimensional model may miss important kinds of prosperity, particularly in countries where traditional subsistence-based livelihoods coexist with modern cash economies. Using multiple correspondence analysis to analyze representative household data from six countries-Nepal, Bangladesh, Ethiopia, Kenya, Tanzania and Guatemala-across three world regions, we identify a number of independent dimension of wealth, each with a clear link to locally relevant pathways to success in cash and agricultural economies. In all cases, the first dimension identified by this approach replicates standard one-dimensional estimates and captures success in cash economies. The novel dimensions we identify reflect success in different agricultural sectors and are independently associated with key benchmarks of food security and human growth, such as adult body mass index and child height. The multidimensional models of wealth we describe here provide new opportunities for examining the causes and consequences of wealth inequality that go beyond success in cash economies, for tracing the emergence of hybrid pathways to prosperity, and for assessing how these different pathways to economic success carry different health risks and social opportunities.

Material wealth in 3D: Mapping multiple paths to prosperity in low- and middle- income countries

PubMed Central

Hadley, Craig; Hackman, Joseph

2017-01-01

Material wealth is a key factor shaping human development and well-being. Every year, hundreds of studies in social science and policy fields assess material wealth in low- and middle-income countries assuming that there is a single dimension by which households can move from poverty to prosperity. However, a one-dimensional model may miss important kinds of prosperity, particularly in countries where traditional subsistence-based livelihoods coexist with modern cash economies. Using multiple correspondence analysis to analyze representative household data from six countries—Nepal, Bangladesh, Ethiopia, Kenya, Tanzania and Guatemala—across three world regions, we identify a number of independent dimension of wealth, each with a clear link to locally relevant pathways to success in cash and agricultural economies. In all cases, the first dimension identified by this approach replicates standard one-dimensional estimates and captures success in cash economies. The novel dimensions we identify reflect success in different agricultural sectors and are independently associated with key benchmarks of food security and human growth, such as adult body mass index and child height. The multidimensional models of wealth we describe here provide new opportunities for examining the causes and consequences of wealth inequality that go beyond success in cash economies, for tracing the emergence of hybrid pathways to prosperity, and for assessing how these different pathways to economic success carry different health risks and social opportunities. PMID:28886176

Molecular replacement: tricks and treats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abergel, Chantal, E-mail: chantal.abergel@igs.cnrs-mrs.fr

2013-11-01

To be successful, molecular replacement relies on the quality of the model and of the crystallographic data. Some tricks that could be applied to the models or to the crystal to increase the success rate of MR are discussed here. Molecular replacement is the method of choice for X-ray crystallographic structure determination provided that suitable structural homologues are available in the PDB. Presently, there are ∼80 000 structures in the PDB (8074 were deposited in the year 2012 alone), of which ∼70% have been solved by molecular replacement. For successful molecular replacement the model must cover at least 50% ofmore » the total structure and the C{sub α} r.m.s.d. between the core model and the structure to be solved must be less than 2 Å. Here, an approach originally implemented in the CaspR server (http://www.igs.cnrs-mrs.fr/Caspr2/index.cgi) based on homology modelling to search for a molecular-replacement solution is discussed. How the use of as much information as possible from different sources can improve the model(s) is briefly described. The combination of structural information with distantly related sequences is crucial to optimize the multiple alignment that will define the boundaries of the core domains. PDB clusters (sequences with ≥30% identical residues) can also provide information on the eventual changes in conformation and will help to explore the relative orientations assumed by protein subdomains. Normal-mode analysis can also help in generating series of conformational models in the search for a molecular-replacement solution. Of course, finding a correct solution is only the first step and the accuracy of the identified solution is as important as the data quality to proceed through refinement. Here, some possible reasons for failure are discussed and solutions are proposed using a set of successful examples.« less

Organizing delivery care: what works for safe motherhood?

PubMed Central

Koblinsky, M. A.; Campbell, O.; Heichelheim, J.

1999-01-01

The various means of delivering essential obstetric services are described for settings in which the maternal mortality ratio is relatively low. This review yields four basic models of care, which are best described by organizational characteristics relating to where women give birth and who performs deliveries. In Model 1, deliveries are conducted at home by a community member who has received brief training. In Model 2, delivery takes place at home but is performed by a professional. In Model 3, delivery is performed by a professional in a basic essential obstetric care facility, and in Model 4 all women give birth in a comprehensive essential obstetric care facility with the help of professionals. In each of these models it is assumed that providers do not increase the risk to women, either iatrogenically or through traditional practices. Although there have been some successes with Model 1, there is no evidence that it can provide a maternal mortality ratio under 100 per 100,000 live births. If strong referral mechanisms are in place the introduction of a professional attendant can lead to a marked reduction in the maternal mortality ratio. Countries using Models 2-4, involving the use of professional attendants at delivery, have reduced maternal mortality ratios to 50 or less per 100,000. However, Model 4, although arguably the most advanced, does not necessarily reduce the maternal mortality ratio to less than 100 per 100,000. It appears that not all countries are ready to adopt Model 4, and its affordability by many developing countries is doubtful. There are few data making it possible to determine which configuration with professional attendance is the most cost-effective, and what the constraints are with respect to training, skill maintenance, supervision, regulation, acceptability to women, and other criteria. A successful transition to Models 2-4 requires strong links with the community through either traditional providers or popular demand. PMID:10361757

Fault management for data systems

NASA Technical Reports Server (NTRS)

Boyd, Mark A.; Iverson, David L.; Patterson-Hine, F. Ann

1993-01-01

Issues related to automating the process of fault management (fault diagnosis and response) for data management systems are considered. Substantial benefits are to be gained by successful automation of this process, particularly for large, complex systems. The use of graph-based models to develop a computer assisted fault management system is advocated. The general problem is described and the motivation behind choosing graph-based models over other approaches for developing fault diagnosis computer programs is outlined. Some existing work in the area of graph-based fault diagnosis is reviewed, and a new fault management method which was developed from existing methods is offered. Our method is applied to an automatic telescope system intended as a prototype for future lunar telescope programs. Finally, an application of our method to general data management systems is described.

Observations, theoretical ideas and modeling of turbulent flows: Past, present and future

NASA Technical Reports Server (NTRS)

Chapman, G. T.; Tobak, M.

1985-01-01

Turbulence was analyzed in a historical context featuring the interactions between observations, theoretical ideas, and modeling within three successive movements. These are identified as predominantly statistical, structural and deterministic. The statistical movement is criticized for its failure to deal with the structural elements observed in turbulent flows. The structural movement is criticized for its failure to embody observed structural elements within a formal theory. The deterministic movement is described as having the potential of overcoming these deficiencies by allowing structural elements to exhibit chaotic behavior that is nevertheless embodied within a theory. Four major ideas of this movement are described: bifurcation theory, strange attractors, fractals, and the renormalization group. A framework for the future study of turbulent flows is proposed, based on the premises of the deterministic movement.

A Roadmap for Aircraft Engine Life Extending Control

NASA Technical Reports Server (NTRS)

Guo, Ten-Huei

2001-01-01

The concept of Aircraft Engine Life Extending Control is introduced. A brief description of the tradeoffs between performance and engine life are first explained. The overall goal of the life extending controller is to reduce the engine operating cost by extending the on-wing engine life while improving operational safety. The research results for NASA's Rocket Engine life extending control program are also briefly described. Major building blocks of the Engine Life Extending Control architecture are examined. These blocks include: life prediction models, engine operation models, stress and thermal analysis tools, control schemes, and intelligent control systems. The technology areas that would likely impact the successful implementation of an aircraft engine life extending control are also briefly described. Near, intermediate, and long term goals of NASA's activities are also presented.

Leadership of risk decision making in a complex, technology organization: The deliberative decision making model

NASA Astrophysics Data System (ADS)

Flaming, Susan C.

2007-12-01

The continuing saga of satellite technology development is as much a story of successful risk management as of innovative engineering. How do program leaders on complex, technology projects manage high stakes risks that threaten business success and satellite performance? This grounded theory study of risk decision making portrays decision leadership practices at one communication satellite company. Integrated product team (IPT) leaders of multi-million dollar programs were interviewed and observed to develop an extensive description of the leadership skills required to navigate organizational influences and drive challenging risk decisions to closure. Based on the study's findings the researcher proposes a new decision making model, Deliberative Decision Making, to describe the program leaders' cognitive and organizational leadership practices. This Deliberative Model extends the insights of prominent decision making models including the rational (or classical) and the naturalistic and qualifies claims made by bounded rationality theory. The Deliberative Model describes how leaders proactively engage resources to play a variety of decision leadership roles. The Model incorporates six distinct types of leadership decision activities, undertaken in varying sequence based on the challenges posed by specific risks. Novel features of the Deliberative Decision Model include: an inventory of leadership methods for managing task challenges, potential stakeholder bias and debates; four types of leadership meta-decisions that guide decision processes, and aligned organizational culture. Both supporting and constraining organizational influences were observed as leaders managed major risks, requiring active leadership on the most difficult decisions. Although the company's engineering culture emphasized the importance of data-based decisions, the uncertainties intrinsic to satellite risks required expert engineering judgment to be exercised throughout. An investigation into the co-variation of decision methods with uncertainty suggests that perceived risk severity may serve as a robust indicator for choices about decision practices. The Deliberative Decision processes incorporate multiple organizational and cultural controls as cross-checks to mitigate potential parochial bias of individuals, stakeholder groups, or leaders. Overall the Deliberative Decision framework describes how expert leadership practices, supportive organizational systems along with aligned cultural values and behavioral norms help leaders drive high stakes risk decisions to closure in this complex, advanced-technology setting.

The Current Landscape of Transitions of Care Practice Models: A Scoping Review.

PubMed

Rochester-Eyeguokan, Charmaine D; Pincus, Kathleen J; Patel, Roshni S; Reitz, Shirley J

2016-01-01

Transitions of care (TOC) are a set of actions to ensure patient coordination and continuity of care as patients transfer between different locations or levels. During transitions associated with chronic or acute illness, vulnerable patients may be placed at risk with fragmented systems compromising their health and safety. In addition, poor care transitions also have an enormous impact on health care spending. The primary objective of this scoping review is to summarize the current landscape of practice models that deliver TOC services in the United States. The secondary objective is to use the information to characterize the current state of best practice models. A search of the PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, Web of Science, International Pharmaceutical Abstracts, National Center for Biotechnology Information at the U.S. National Library of Medicine, and Cochrane Library databases (January 1, 2000-April 13, 2015) for articles pertaining to TOC models, limited to U.S. studies published in the English language with human subjects, gleaned 1362 articles. An additional 26 articles were added from the gray literature. Articles meeting inclusion criteria underwent a second review and were categorized into four groups: background information, original TOC research articles not evaluating practice model interventions, original TOC research articles describing practice models, and systematic or Cochrane reviews. The reviewers met weekly to discuss the challenges and resolve disagreements regarding literature reviews with consensus before progressing. A total of 188 articles describing TOC practice models met the inclusion criteria. Despite the strengths of several quality TOC models, none satisfied all the components recommended by leading experts. Multimodal interventions by multidisciplinary teams appear to represent a best practice model for TOC to improve patient outcomes and reduce readmissions, but one size does not fit all. Best model TOC services must include services along the TOC continuum: pretransition and posttransition, as well as at home and in outpatient health care settings. Studies clearly show that single-modal interventions are rarely successful in reducing readmissions and that successful TOC services must be multimodal and multidisciplinary, and continue throughout the care transition. Utilizing best practice TOC models described in this article as a starting point, practitioners interested in developing their own TOC program should test these tools in new practice environments and add to the body of literature by publishing their findings. © 2016 Pharmacotherapy Publications, Inc.

A genetically optimized kinetic model for ethanol electro-oxidation on Pt-based binary catalysts used in direct ethanol fuel cells

NASA Astrophysics Data System (ADS)

Sánchez-Monreal, Juan; García-Salaberri, Pablo A.; Vera, Marcos

2017-09-01

A one-dimensional model is proposed for the anode of a liquid-feed direct ethanol fuel cell. The complex kinetics of the ethanol electro-oxidation reaction is described using a multi-step reaction mechanism that considers free and adsorbed intermediate species on Pt-based binary catalysts. The adsorbed species are modeled using coverage factors to account for the blockage of the active reaction sites on the catalyst surface. The reaction rates are described by Butler-Volmer equations that are coupled to a one-dimensional mass transport model, which incorporates the effect of ethanol and acetaldehyde crossover. The proposed kinetic model circumvents the acetaldehyde bottleneck effect observed in previous studies by incorporating CH3CHOHads among the adsorbed intermediates. A multi-objetive genetic algorithm is used to determine the reaction constants using anode polarization and product selectivity data obtained from the literature. By adjusting the reaction constants using the methodology developed here, different catalyst layers could be modeled and their selectivities could be successfully reproduced.

The changing paradigm in surgery is system integration: How do we respond?

PubMed

Zenilman, Michael E; Freischlag, Julie-Ann

2017-12-08

With expansion of health care systems across the country, close relationships need to be developed between academic medical centers and their affiliated community hospitals. This creates opportunity to integrate surgical programs across different hospitals. Herein we describe a model of surgical integration at the system level of five large hospitals. We discuss utilizing advantages that both the academic and community hospital bring to the model. A close relationship between an interdisciplinary team, which includes the academic surgical chair, a regional director liaison who was embedded in the community, individual hospital leadership, and practice plan leaders was created. Three pillars as a foundation to success were physician leadership, the use of system infrastructure and development of new processes. This resulted in development of trust, leading to successful recruitments, models of employment and expansion into novel areas of patient safety. Once created, new opportunities for programming for surgical safety across the health care were identified. Copyright © 2017 Elsevier Inc. All rights reserved.

Lean leadership attributes: a systematic review of the literature.

PubMed

Aij, Kjeld Harald; Teunissen, Maurits

2017-10-09

Purpose Emphasis on quality and reducing costs has led many health-care organizations to reconfigure their management, process, and quality control infrastructures. Many are lean, a management philosophy with roots in manufacturing industries that emphasizes elimination of waste. Successful lean implementation requires systemic change and strong leadership. Despite the importance of leadership to successful lean implementation, few researchers have probed the question of ideal leadership attributes to achieve lean thinking in health care. The purpose of this paper is to provide insight into applicable attributes for lean leaders in health care. Design/methodology/approach The authors systematically reviewed the literature on principles of leadership and, using Dombrowski and Mielke's (2013) conceptual model of lean leadership, developed a parallel theoretical model for lean leadership in health care. Findings This work contributes to the development of a new framework for describing leadership attributes within lean management of health care. Originality/value The summary of attributes can provide a model for health-care leaders to apply lean in their organizations.

Trust Model for Protection of Personal Health Data in a Global Environment.

PubMed

Ruotsalainen, Pekka; Blobel, Bernd

2017-01-01

Successful health care, eHealth, digital health, and personal health systems increasingly take place in cross-jurisdictional, dynamic and risk-encumbered information space. They require rich amount of personal health information (PHI). Trust is and will be the cornerstone and prerequisite for successful health services. In global environments, trust cannot be expected as granted. In this paper, health service in the global environment is perceived as a meta-system, and a trust management model is developed to support it. The predefined trusting belief currently used in health care is not transferable to global environments. In the authors' model, the level of trust is dynamically calculated from measurable attributes. These attributes describe trust features of the service provider and its environment. The calculated trust value or profile can be used in defining the risk service user has to accept when disclosing PHI, and in definition of additional privacy and security safeguards before disclosing PHI and/or using services.

Marketing imaging services.

PubMed

Bouchard, E A

1992-01-01

"Communication with physicians and patients is critical to successfully marketing technology," says Mr. Bouchard, author of a new handbook for radiology managers. In this section from his book, he describes the components of a successful marketing plan and tries to dispel several myths about marketing. He also describes benchmarks for success, and provides a sample plan to promote mammography services.

Precision analysis of the photomultiplier response to ultra low signals

NASA Astrophysics Data System (ADS)

Degtiarenko, Pavel

2017-11-01

A new computational model for the description of the photon detector response functions measured in conditions of low light is presented, together with examples of the observed photomultiplier signal amplitude distributions, successfully described using the parameterized model equation. In extension to the previously known approximations, the new model describes the underlying discrete statistical behavior of the photoelectron cascade multiplication processes in photon detectors with complex non-uniform gain structure of the first dynode. Important features of the model include the ability to represent the true single-photoelectron spectra from different photomultipliers with a variety of parameterized shapes, reflecting the variability in the design and in the individual parameters of the detectors. The new software tool is available for evaluation of the detectors' performance, response, and efficiency parameters that may be used in various applications including the ultra low background experiments such as the searches for Dark Matter and rare decays, underground neutrino studies, optimizing operations of the Cherenkov light detectors, help in the detector selection procedures, and in the experiment simulations.

ICT & OTs: a model of information and communications technology acceptance and utilisation by occupational therapists (part 2).

PubMed

Schaper, Louise; Pervan, Graham

2007-01-01

The research reported in this paper describes the development, empirical validation and analysis of a model of technology acceptance by Australian occupational therapists. The study described involved the collection of quantitative data through a national survey. The theoretical significance of this work is that it uses a thoroughly constructed research model, with one of the largest sample sizes ever tested (n=1605), to extend technology acceptance research into the health sector. Results provide strong support for the model. This work reveals the complexity of the constructs and relationships that influence technology acceptance and highlights the need to include sociotechnical and system issues in studies of technology acceptance in healthcare to improve information system implementation success in this arena. The results of this study have practical and theoretical implications for health informaticians and researchers in the field of health informatics and information systems, tertiary educators, Commonwealth and State Governments and the allied health professions.

Development of a model protection and dynamic response monitoring system for the national transonic facility

NASA Technical Reports Server (NTRS)

Young, Clarence P., Jr.; Balakrishna, S.; Kilgore, W. Allen

1995-01-01

A state-of-the-art, computerized mode protection and dynamic response monitoring system has been developed for the NASA Langley Research Center National Transonic Facility (NTF). This report describes the development of the model protection and shutdown system (MPSS). A technical description of the system is given along with discussions on operation and capabilities of the system. Applications of the system to vibration problems are presented to demonstrate the system capabilities, typical applications, versatility, and investment research return derived from the system to date. The system was custom designed for the NTF but can be used at other facilities or for other dynamic measurement/diagnostic applications. Potential commercial uses of the system are described. System capability has been demonstrated for forced response testing and for characterizing and quantifying bias errors for onboard inertial model attitude measurement devices. The system is installed in the NTF control room and has been used successfully for monitoring, recording and analyzing the dynamic response of several model systems tested in the NTF.

On the Scene: Developing a Nurse Care Coordinator Role at City of Hope.

PubMed

Johnson, Shirley A; Giesie, Pamela D; Ireland, Anne M; Rice, Robert David; Thomson, Brenda K

2016-01-01

We describe the development of an oncology solid tumor disease-focused care coordination model. Consistent with our strategic plan to provide patient- and family-centered care and to organize care around disease management teams, we developed the role of nurse care coordinator as an integral team member in our care delivery model. Managing a defined high-risk patient population across the care trajectory, these nurses provide stable points of contact and continuity for patients and families as they navigate the complex treatments and systems required to deliver cancer care. We describe role delineation and staffing models; role clarity between the role of the nurse care coordinator and the case manager; core curriculum development; the use of workflow management tools to support the touch points of the patient and members of the care team; and the incorporation of electronic medical records and data streams to inform the care delivery model. We identify measures that we will use to evaluate the success of our program.

The dark side of galaxy colour: evidence from new SDSS measurements of galaxy clustering and lensing

NASA Astrophysics Data System (ADS)

Hearin, Andrew P.; Watson, Douglas F.; Becker, Matthew R.; Reyes, Reinabelle; Berlind, Andreas A.; Zentner, Andrew R.

2014-10-01

The age-matching model has recently been shown to predict correctly the luminosity L and g - r colour of galaxies residing within dark matter haloes. The central tenet of the model is intuitive: older haloes tend to host galaxies with older stellar populations. In this paper, we demonstrate that age matching also correctly predicts the g - r colour trends exhibited in a wide variety of statistics of the galaxy distribution for stellar mass M* threshold samples. In particular, we present new Sloan Digital Sky Survey (SDSS) measurements of galaxy clustering and the galaxy-galaxy lensing signal ΔΣ as a function of M* and g - r colour, and show that age matching exhibits remarkable agreement with these and other statistics of low-redshift galaxies. In so doing, we also demonstrate good agreement between the galaxy-galaxy lensing observed by SDSS and the ΔΣ signal predicted by abundance matching, a new success of this model. We describe how age matching is a specific example of a larger class of conditional abundance matching models (CAM), a theoretical framework we introduce here for the first time. CAM provides a general formalism to study correlations at fixed mass between any galaxy property and any halo property. The striking success of our simple implementation of CAM suggests that this technique has the potential to describe the same set of data as alternative models, but with a dramatic reduction in the required number of parameters. CAM achieves this reduction by exploiting the capability of contemporary N-body simulations to determine dark matter halo properties other than mass alone, which distinguishes our model from conventional approaches to the galaxy-halo connection.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lechman, Jeremy B.; Battaile, Corbett Chandler.; Bolintineanu, Dan

This report summarizes a project in which the authors sought to develop and deploy: (i) experimental techniques to elucidate the complex, multiscale nature of thermal transport in particle-based materials; and (ii) modeling approaches to address current challenges in predicting performance variability of materials (e.g., identifying and characterizing physical- chemical processes and their couplings across multiple length and time scales, modeling information transfer between scales, and statically and dynamically resolving material structure and its evolution during manufacturing and device performance). Experimentally, several capabilities were successfully advanced. As discussed in Chapter 2 a flash diffusivity capability for measuring homogeneous thermal conductivity ofmore » pyrotechnic powders (and beyond) was advanced; leading to enhanced characterization of pyrotechnic materials and properties impacting component development. Chapter 4 describes success for the first time, although preliminary, in resolving thermal fields at speeds and spatial scales relevant to energetic components. Chapter 7 summarizes the first ever (as far as the authors know) application of TDTR to actual pyrotechnic materials. This is the first attempt to actually characterize these materials at the interfacial scale. On the modeling side, new capabilities in image processing of experimental microstructures and direct numerical simulation on complicated structures were advanced (see Chapters 3 and 5). In addition, modeling work described in Chapter 8 led to improved prediction of interface thermal conductance from first principles calculations. Toward the second point, for a model system of packed particles, significant headway was made in implementing numerical algorithms and collecting data to justify the approach in terms of highlighting the phenomena at play and pointing the way forward in developing and informing the kind of modeling approach originally envisioned (see Chapter 6). In both cases much more remains to be accomplished.« less

Interorganizational health care systems implementations: an exploratory study of early electronic commerce initiatives.

PubMed

Payton, F C; Ginzberg, M J

2001-01-01

Changing business practices, customers needs, and market dynamics have driven many organizations to implement interorganizational systems (IOSs). IOSs have been successfully implemented in the banking, cotton, airline, and consumer-goods industries, and recently attention has turned to the health care industry. This article describes an exploratory study of health care IOS implementations based on the voluntary community health information network (CHIN) model.

A Pathway to Continued Success on the Job. A Final Report, July 1, 1998-June 30, 1999 [and] Product.

ERIC Educational Resources Information Center

Cort, Maureen A.; Pappalardo, Michele F.; Gonzalez, Manuel A.

This manual was developed by a project to create a model program that integrates basic skills instruction with requirements of welfare reform, and the project's final report describes activities taken to develop the manual. The report details the problem, goals, procedures, objectives met and not met, and an evaluation. The manual is designed to…

Occupational health in Malaysia.

PubMed

Rampal, Krishna Gopal; Aw, Tar-Ching; Jefferelli, Shamsul Bahrin

2002-01-01

This article provides a detailed examination of Malaysian occupational health agencies and their roles in formulating and enforcing standards, promoting occupational health and safety (OSH), and providing advisory services. Available OSH training is described, and the need for policies and personnel in various industries is outlined. Further, the authors discuss how international models and collaboration have influenced Malaysian OSH, and how some successes can be repeated and failures remedied.

Learning Partners: Escribamos! Leamos! Juguemos a las Ciencias! Juguemos a las Matematicas! (Learning Partners: Let's Write! Let's Read! Let's Play Mathematics! Let's Play Science!)

ERIC Educational Resources Information Center

Office of Educational Research and Improvement (ED), Washington, DC.

This Spanish-language document consists of four single-sheet sets of guidelines developed by the Family Involvement Partnership for Learning to assist parents in facilitating their children's elementary school success. The front part of the sheets describes general ways parents can support their children, including modeling writing, reading aloud,…

Rethinking Remedial Education: The Role of MSIs in Serving Under-Prepared Students in the 21st Century

ERIC Educational Resources Information Center

Bustillos, Leticia Tomas

2012-01-01

The purpose of this brief, the third in a series released by the Institute for Higher Education Policy (IHEP), is twofold: (1) To describe the emerging themes from the Lumina MSI-Models of Success initiative, and (2) to examine the context of remedial education and the discourse centered on the policy, practice, and role of postsecondary settings…

Broadway High School: Moving Ahead in Math. Onward to Excellence II: Committing to CHANGE with OTE II.

ERIC Educational Resources Information Center

Northwest Regional Educational Lab., Portland, OR. School Improvement Program.

This document describes the school reform movement at Broadway High School in rural Virginia which has led to great success in mathematics achievement as proven by the Virginia Standards of Learning (SOL) tests. The Onward to Excellence II model provided a way for the faculty to focus on math, especially Algebra I, and to involve the entire school…

The environmental outlook for lead in Europe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, D.N.

1993-05-01

The Regulation being developed by the European Commission to comply with the Basel Convention on the transboundary movement of waste and how this will impact on trade with other regions is described. The specific question of lead-acid battery recycling and how this is being pursued in Europe using a very different approach to the BCI model which has proved so successful in the US is addressed.