PEEX Modelling Platform for Seamless Environmental Prediction

NASA Astrophysics Data System (ADS)

Baklanov, Alexander; Mahura, Alexander; Arnold, Stephen; Makkonen, Risto; Petäjä, Tuukka; Kerminen, Veli-Matti; Lappalainen, Hanna K.; Ezau, Igor; Nuterman, Roman; Zhang, Wen; Penenko, Alexey; Gordov, Evgeny; Zilitinkevich, Sergej; Kulmala, Markku

2017-04-01

The Pan-Eurasian EXperiment (PEEX) is a multidisciplinary, multi-scale research programme stared in 2012 and aimed at resolving the major uncertainties in Earth System Science and global sustainability issues concerning the Arctic and boreal Northern Eurasian regions and in China. Such challenges include climate change, air quality, biodiversity loss, chemicalization, food supply, and the use of natural resources by mining, industry, energy production and transport. The research infrastructure introduces the current state of the art modeling platform and observation systems in the Pan-Eurasian region and presents the future baselines for the coherent and coordinated research infrastructures in the PEEX domain. The PEEX modeling Platform is characterized by a complex seamless integrated Earth System Modeling (ESM) approach, in combination with specific models of different processes and elements of the system, acting on different temporal and spatial scales. The ensemble approach is taken to the integration of modeling results from different models, participants and countries. PEEX utilizes the full potential of a hierarchy of models: scenario analysis, inverse modeling, and modeling based on measurement needs and processes. The models are validated and constrained by available in-situ and remote sensing data of various spatial and temporal scales using data assimilation and top-down modeling. The analyses of the anticipated large volumes of data produced by available models and sensors will be supported by a dedicated virtual research environment developed for these purposes.

A software platform for continuum modeling of ion channels based on unstructured mesh

NASA Astrophysics Data System (ADS)

Tu, B.; Bai, S. Y.; Chen, M. X.; Xie, Y.; Zhang, L. B.; Lu, B. Z.

2014-01-01

Most traditional continuum molecular modeling adopted finite difference or finite volume methods which were based on a structured mesh (grid). Unstructured meshes were only occasionally used, but an increased number of applications emerge in molecular simulations. To facilitate the continuum modeling of biomolecular systems based on unstructured meshes, we are developing a software platform with tools which are particularly beneficial to those approaches. This work describes the software system specifically for the simulation of a typical, complex molecular procedure: ion transport through a three-dimensional channel system that consists of a protein and a membrane. The platform contains three parts: a meshing tool chain for ion channel systems, a parallel finite element solver for the Poisson-Nernst-Planck equations describing the electrodiffusion process of ion transport, and a visualization program for continuum molecular modeling. The meshing tool chain in the platform, which consists of a set of mesh generation tools, is able to generate high-quality surface and volume meshes for ion channel systems. The parallel finite element solver in our platform is based on the parallel adaptive finite element package PHG which wass developed by one of the authors [1]. As a featured component of the platform, a new visualization program, VCMM, has specifically been developed for continuum molecular modeling with an emphasis on providing useful facilities for unstructured mesh-based methods and for their output analysis and visualization. VCMM provides a graphic user interface and consists of three modules: a molecular module, a meshing module and a numerical module. A demonstration of the platform is provided with a study of two real proteins, the connexin 26 and hemolysin ion channels.

Which benefits in the use of a modeling platform : The VSoil example.

NASA Astrophysics Data System (ADS)

Lafolie, François; Cousin, Isabelle; Mollier, Alain; Pot, Valérie; Maron, Pierre-Alain; Moitrier, Nicolas; Nouguier, Cedric; Moitrier, Nathalie; Beudez, Nicolas

2015-04-01

In the environmental community the need for coupling the models and the associated knowledges emerged recently. The development of a coupling tool or of a modeling platform is mainly driven by the necessity to create models accounting for multiple processes and to take into account the feed back between these processes. Models focusing on a restricted number of processes exist and thus the coupling of these numerical tools appeared as an efficient and rapid mean to fill up the identified gaps. Several tools have been proposed : OMS3 (David et al. 2013) ; CSDMS framework (Peckham et al. 2013) ; the Open MI project developed within the frame of European Community (Open MI, 2011). However, what we should expect from a modeling platform could be more ambitious than only coupling existing numerical codes. We believe that we need to share easily not only our numerical representations but also the attached knowledges. We need to rapidly and easily develop complex models to have tools to bring responses to current issues on soil functioning and soil evolution within the frame of global change. We also need to share in a common frame our visions of soil functioning at various scales, one the one hand to strengthen our collaborations, and, on the other hand, to make them visible by the other communities working on environmental issues. The presentation will briefly present the VSoil platform. The platform is able to manipulate concepts and numerical representations of these processes. The tool helps in assembling modules to create a model and automatically generates an executable code and a GUI. Potentialities of the tool will be illustrated on few selected cases.

Development of a Zigbee platform for bioinstrumentation.

PubMed

Cifuentes, Carlos A; Gentiletti, Gabriel G; Suarez, Marco J; Rodriguez, Luis E

2010-01-01

This paper presents the development of a network platform which allows connecting multiple individual wireless devices for transmitting bioelectrics and biomechanics signals for application in a hospital network, or continuous monitoring in a patient's diary life. The Zigbee platform development proposal was made in three stages: 1) Hardware development, including the construction of a prototype network node and the integration of sensors, (2) Evaluation, in order to define the specifications of each node and scope of communication and (3) The Zigbee Network Implementation for bioinstrumentation based on ZigBee Health Care public application profile (ZHC). Finally, this work presents the experimental results based on measurements of Lost Packets and LQI (Link Quality Indicator), and the Zigbee Platform configuration for Bioinstrumentation in operation.

Urban search mobile platform modeling in hindered access conditions

NASA Astrophysics Data System (ADS)

Barankova, I. I.; Mikhailova, U. V.; Kalugina, O. B.; Barankov, V. V.

2018-05-01

The article explores the control system simulation and the design of the experimental model of the rescue robot mobile platform. The functional interface, a structural functional diagram of the mobile platform control unit, and a functional control scheme for the mobile platform of secure robot were modeled. The task of design a mobile platform for urban searching in hindered access conditions is realized through the use of a mechanical basis with a chassis and crawler drive, a warning device, human heat sensors and a microcontroller based on Arduino platforms.

Framework Programmable Platform for the Advanced Software Development Workstation: Preliminary system design document

NASA Technical Reports Server (NTRS)

Mayer, Richard J.; Blinn, Thomas M.; Mayer, Paula S. D.; Ackley, Keith A.; Crump, John W., IV; Henderson, Richard; Futrell, Michael T.

1991-01-01

The Framework Programmable Software Development Platform (FPP) is a project aimed at combining effective tool and data integration mechanisms with a model of the software development process in an intelligent integrated software environment. Guided by the model, this system development framework will take advantage of an integrated operating environment to automate effectively the management of the software development process so that costly mistakes during the development phase can be eliminated. The focus here is on the design of components that make up the FPP. These components serve as supporting systems for the Integration Mechanism and the Framework Processor and provide the 'glue' that ties the FPP together. Also discussed are the components that allow the platform to operate in a distributed, heterogeneous environment and to manage the development and evolution of software system artifacts.

Cosmogenic nuclides application on French Mediterranean shore platform development

NASA Astrophysics Data System (ADS)

Giuliano, Jérémy; Lebourg, Thomas; Godard, Vincent; Dewez, Thomas; Braucher, Régis; Bourlès, Didier; Marçot, Nathalie

2014-05-01

Rocky shorelines are among the most common elements of the world's littoral zone, and the potential effects of rising sea level on the ever increasing populations require a better understanding of their dynamics. The sinuosity and heterogeneity of the shoreline morphology at large and intermediate wavelengths (1-100 km) results from their constant evolution under the combined influence of marine and continental forcings. This macro-scale organization is the expression of the action of elementary erosion processes acting at shorter wavelengths (<1 km) which lead to the development of shore platforms by landward retreat of cliff edges. Modern analytical techniques (laser-scaning, micro-erosion meters, aerial surveys) constitute appropriate methods to identify and quantify processes of cliff retreat to 1-100 yrs time-scales. But over this time frame, shore platform development appears imperceptible. Precise knowledge of long-term erosion rates are needed to understand rocky shore evolution, and develop quantitative modeling of platform development. Rocky coasts constitute a Quaternary sea level evolution archive that is partly preserved and progressively destroyed. One major challenges is to determine the degree to which coast morphologies are (i) contemporary, (ii) or ancient features inherited, (iii) or partly inherited from Quaternary interglacial stages. In order to fill the lack of long term coast morphodynamic data, we use cosmogenic nuclides (36Cl) to study abrasion surfaces carved in carbonates lithologies along the French Mediterranean coast, in a microtidal environment (Côte Bleue, West of Marseille). 36Cl concentration heritage influences strongly our interpretations in terms of age and denudation of the surfaces. We propose to constrain heritage in sampling oldest relic marine surfaces at 10m of altitude, and along recent cliff scarp. 36Cl concentrations show that the lowest platforms near sea level are contemporary and the highest ones (8-14 m above sea

Benchmarking of dynamic simulation predictions in two software platforms using an upper limb musculoskeletal model

PubMed Central

Saul, Katherine R.; Hu, Xiao; Goehler, Craig M.; Vidt, Meghan E.; Daly, Melissa; Velisar, Anca; Murray, Wendy M.

2014-01-01

Several opensource or commercially available software platforms are widely used to develop dynamic simulations of movement. While computational approaches are conceptually similar across platforms, technical differences in implementation may influence output. We present a new upper limb dynamic model as a tool to evaluate potential differences in predictive behavior between platforms. We evaluated to what extent differences in technical implementations in popular simulation software environments result in differences in kinematic predictions for single and multijoint movements using EMG- and optimization-based approaches for deriving control signals. We illustrate the benchmarking comparison using SIMM-Dynamics Pipeline-SD/Fast and OpenSim platforms. The most substantial divergence results from differences in muscle model and actuator paths. This model is a valuable resource and is available for download by other researchers. The model, data, and simulation results presented here can be used by future researchers to benchmark other software platforms and software upgrades for these two platforms. PMID:24995410

Benchmarking of dynamic simulation predictions in two software platforms using an upper limb musculoskeletal model.

PubMed

Saul, Katherine R; Hu, Xiao; Goehler, Craig M; Vidt, Meghan E; Daly, Melissa; Velisar, Anca; Murray, Wendy M

2015-01-01

Several opensource or commercially available software platforms are widely used to develop dynamic simulations of movement. While computational approaches are conceptually similar across platforms, technical differences in implementation may influence output. We present a new upper limb dynamic model as a tool to evaluate potential differences in predictive behavior between platforms. We evaluated to what extent differences in technical implementations in popular simulation software environments result in differences in kinematic predictions for single and multijoint movements using EMG- and optimization-based approaches for deriving control signals. We illustrate the benchmarking comparison using SIMM-Dynamics Pipeline-SD/Fast and OpenSim platforms. The most substantial divergence results from differences in muscle model and actuator paths. This model is a valuable resource and is available for download by other researchers. The model, data, and simulation results presented here can be used by future researchers to benchmark other software platforms and software upgrades for these two platforms.

Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development

PubMed Central

Ribas, João; Sadeghi, Hossein; Manbachi, Amir; Leijten, Jeroen; Brinegar, Katelyn; Zhang, Yu Shrike; Ferreira, Lino

2016-01-01

Abstract Cardiovascular diseases are prevalent worldwide and are the most frequent causes of death in the United States. Although spending in drug discovery/development has increased, the amount of drug approvals has seen a progressive decline. Particularly, adverse side effects to the heart and general vasculature have become common causes for preclinical project closures, and preclinical models do not fully recapitulate human in vivo dynamics. Recently, organs-on-a-chip technologies have been proposed to mimic the dynamic conditions of the cardiovascular system—in particular, heart and general vasculature. These systems pay particular attention to mimicking structural organization, shear stress, transmural pressure, mechanical stretching, and electrical stimulation. Heart- and vasculature-on-a-chip platforms have been successfully generated to study a variety of physiological phenomena, model diseases, and probe the effects of drugs. Here, we review and discuss recent breakthroughs in the development of cardiovascular organs-on-a-chip platforms, and their current and future applications in the area of drug discovery and development. PMID:28971113

Development of deployable structures for large space platforms. Volume 2: Design development

NASA Technical Reports Server (NTRS)

Greenberg, H. S.

1983-01-01

Design evolution, test article design, test article mass properties, and structural analysis of deployable platform systems are discussed. Orbit transfer vehicle (OTV) hangar development, OTV hangar concept selection, and manned module development are discussed. Deployable platform systems requirements, material data base, technology development needs, concept selection and deployable volume enclosures are also discussed.

Framework programmable platform for the advanced software development workstation. Integration mechanism design document

NASA Technical Reports Server (NTRS)

Mayer, Richard J.; Blinn, Thomas M.; Mayer, Paula S. D.; Reddy, Uday; Ackley, Keith; Futrell, Mike

1991-01-01

The Framework Programmable Software Development Platform (FPP) is a project aimed at combining effective tool and data integration mechanisms with a model of the software development process in an intelligent integrated software development environment. Guided by this model, this system development framework will take advantage of an integrated operating environment to automate effectively the management of the software development process so that costly mistakes during the development phase can be eliminated.

Real-time GIS data model and sensor web service platform for environmental data management.

PubMed

Gong, Jianya; Geng, Jing; Chen, Zeqiang

2015-01-09

Effective environmental data management is meaningful for human health. In the past, environmental data management involved developing a specific environmental data management system, but this method often lacks real-time data retrieving and sharing/interoperating capability. With the development of information technology, a Geospatial Service Web method is proposed that can be employed for environmental data management. The purpose of this study is to determine a method to realize environmental data management under the Geospatial Service Web framework. A real-time GIS (Geographic Information System) data model and a Sensor Web service platform to realize environmental data management under the Geospatial Service Web framework are proposed in this study. The real-time GIS data model manages real-time data. The Sensor Web service platform is applied to support the realization of the real-time GIS data model based on the Sensor Web technologies. To support the realization of the proposed real-time GIS data model, a Sensor Web service platform is implemented. Real-time environmental data, such as meteorological data, air quality data, soil moisture data, soil temperature data, and landslide data, are managed in the Sensor Web service platform. In addition, two use cases of real-time air quality monitoring and real-time soil moisture monitoring based on the real-time GIS data model in the Sensor Web service platform are realized and demonstrated. The total time efficiency of the two experiments is 3.7 s and 9.2 s. The experimental results show that the method integrating real-time GIS data model and Sensor Web Service Platform is an effective way to manage environmental data under the Geospatial Service Web framework.

NEMOTAM: tangent and adjoint models for the ocean modelling platform NEMO

NASA Astrophysics Data System (ADS)

Vidard, A.; Bouttier, P.-A.; Vigilant, F.

2015-04-01

Tangent linear and adjoint models (TAMs) are efficient tools to analyse and to control dynamical systems such as NEMO. They can be involved in a large range of applications such as sensitivity analysis, parameter estimation or the computation of characteristic vectors. A TAM is also required by the 4D-Var algorithm, which is one of the major methods in data assimilation. This paper describes the development and the validation of the tangent linear and adjoint model for the NEMO ocean modelling platform (NEMOTAM). The diagnostic tools that are available alongside NEMOTAM are detailed and discussed, and several applications are also presented.

NEMOTAM: tangent and adjoint models for the ocean modelling platform NEMO

NASA Astrophysics Data System (ADS)

Vidard, A.; Bouttier, P.-A.; Vigilant, F.

2014-10-01

The tangent linear and adjoint model (TAM) are efficient tools to analyse and to control dynamical systems such as NEMO. They can be involved in a large range of applications such as sensitivity analysis, parameter estimation or the computation of characteristics vectors. TAM is also required by the 4-D-VAR algorithm which is one of the major method in Data Assimilation. This paper describes the development and the validation of the Tangent linear and Adjoint Model for the NEMO ocean modelling platform (NEMOTAM). The diagnostic tools that are available alongside NEMOTAM are detailed and discussed and several applications are also presented.

Future robotic platforms in urologic surgery: Recent Developments

PubMed Central

Herrell, S. Duke; Webster, Robert; Simaan, Nabil

2014-01-01

Purpose of review To review recent developments at Vanderbilt University of new robotic technologies and platforms designed for minimally invasive urologic surgery and their design rationale and potential roles in advancing current urologic surgical practice. Recent findings Emerging robotic platforms are being developed to improve performance of a wider variety of urologic interventions beyond the standard minimally invasive robotic urologic surgeries conducted presently with the da Vinci platform. These newer platforms are designed to incorporate significant advantages of robotics to improve the safety and outcomes of transurethral bladder surgery and surveillance, further decrease the invasiveness of interventions by advancing LESS surgery, and allow for previously impossible needle access and ablation delivery. Summary Three new robotic surgical technologies that have been developed at Vanderbilt University are reviewed, including a robotic transurethral system to enhance bladder surveillance and TURBT, a purpose-specific robotic system for LESS, and a needle sized robot that can be used as either a steerable needle or small surgeon-controlled micro-laparoscopic manipulator. PMID:24253803

Development of vibration isolation platform for low amplitude vibration

NASA Astrophysics Data System (ADS)

Lee, Dae-Oen; Park, Geeyong; Han, Jae-Hung

2014-03-01

The performance of high precision payloads on board a satellite is extremely sensitive to vibration. Although vibration environment of a satellite on orbit is very gentle compared to the launch environment, even a low amplitude vibration disturbances generated by reaction wheel assembly, cryocoolers, etc may cause serious problems in performing tasks such as capturing high resolution images. The most commonly taken approach to protect sensitive payloads from performance degrading vibration is application of vibration isolator. In this paper, development of vibration isolation platform for low amplitude vibration is discussed. Firstly, single axis vibration isolator is developed by adapting three parameter model using bellows and viscous fluid. The isolation performance of the developed single axis isolator is evaluated by measuring force transmissibility. The measured transmissibility shows that both the low Q-factor (about 2) and the high roll-off rate (about -40 dB/dec) are achieved with the developed isolator. Then, six single axis isolators are combined to form Stewart platform in cubic configuration to provide multi-axis vibration isolation. The isolation performance of the developed multi-axis isolator is evaluated using a simple prototype reaction wheel model in which wheel imbalance is the major source of vibration. The transmitted force without vibration isolator is measured and compared with the transmitted force with vibration isolator. More than 20 dB reduction of the X and Y direction (radial direction of flywheel) disturbance is observed for rotating wheel speed of 100 Hz and higher.

The 'cube' meta-model for the information system of large health sector organizations--a (platform neutral) mapping tool to integrate information system development with changing business functions and organizational development.

PubMed

Balkányi, László

2002-01-01

To develop information systems (IS) in the changing environment of the health sector, a simple but throughout model, avoiding the techno-jargon of informatics, might be useful for the top management. A platform neutral, extensible, transparent conceptual model should be established. Limitations of current methods lead to a simple, but comprehensive mapping, in the form of a three-dimensional cube. The three 'orthogonal' views are (a) organization functionality, (b) organizational structures and (c) information technology. Each of the cube-sides is described according to its nature. This approach enables to define any kind of an IS component as a certain point/layer/domain of the cube and enables also the management to label all IS components independently form any supplier(s) and/or any specific platform. The model handles changes in organization structure, business functionality and the serving info-system independently form each other. Practical application extends to (a) planning complex, new ISs, (b) guiding development of multi-vendor, multi-site ISs, (c) supporting large-scale public procurement procedures and the contracting, implementation phase by establishing a platform neutral reference, (d) keeping an exhaustive inventory of an existing large-scale system, that handles non-tangible aspects of the IS.

A simple model to estimate the impact of sea-level rise on platform beaches

NASA Astrophysics Data System (ADS)

Taborda, Rui; Ribeiro, Mónica Afonso

2015-04-01

Estimates of future beach evolution in response to sea-level rise are needed to assess coastal vulnerability. A research gap is identified in providing adequate predictive methods to use for platform beaches. This work describes a simple model to evaluate the effects of sea-level rise on platform beaches that relies on the conservation of beach sand volume and assumes an invariant beach profile shape. In closed systems, when compared with the Inundation Model, results show larger retreats; the differences are higher for beaches with wide berms and when the shore platform develops at shallow depths. The application of the proposed model to Cascais (Portugal) beaches, using 21st century sea-level rise scenarios, shows that there will be a significant reduction in beach width.

An open-source software platform for data management, visualisation, model building and model sharing in water, energy and other resource modelling domains.

NASA Astrophysics Data System (ADS)

Knox, S.; Meier, P.; Mohammed, K.; Korteling, B.; Matrosov, E. S.; Hurford, A.; Huskova, I.; Harou, J. J.; Rosenberg, D. E.; Thilmant, A.; Medellin-Azuara, J.; Wicks, J.

2015-12-01

Capacity expansion on resource networks is essential to adapting to economic and population growth and pressures such as climate change. Engineered infrastructure systems such as water, energy, or transport networks require sophisticated and bespoke models to refine management and investment strategies. Successful modeling of such complex systems relies on good data management and advanced methods to visualize and share data.Engineered infrastructure systems are often represented as networks of nodes and links with operating rules describing their interactions. Infrastructure system management and planning can be abstracted to simulating or optimizing new operations and extensions of the network. By separating the data storage of abstract networks from manipulation and modeling we have created a system where infrastructure modeling across various domains is facilitated.We introduce Hydra Platform, a Free Open Source Software designed for analysts and modelers to store, manage and share network topology and data. Hydra Platform is a Python library with a web service layer for remote applications, called Apps, to connect. Apps serve various functions including network or results visualization, data export (e.g. into a proprietary format) or model execution. This Client-Server architecture allows users to manipulate and share centrally stored data. XML templates allow a standardised description of the data structure required for storing network data such that it is compatible with specific models.Hydra Platform represents networks in an abstract way and is therefore not bound to a single modeling domain. It is the Apps that create domain-specific functionality. Using Apps researchers from different domains can incorporate different models within the same network enabling cross-disciplinary modeling while minimizing errors and streamlining data sharing. Separating the Python library from the web layer allows developers to natively expand the software or build web

Controlling Differentiation of Stem Cells for Developing Personalized Organ-on-Chip Platforms.

PubMed

Geraili, Armin; Jafari, Parya; Hassani, Mohsen Sheikh; Araghi, Behnaz Heidary; Mohammadi, Mohammad Hossein; Ghafari, Amir Mohammad; Tamrin, Sara Hasanpour; Modarres, Hassan Pezeshgi; Kolahchi, Ahmad Rezaei; Ahadian, Samad; Sanati-Nezhad, Amir

2018-01-01

Organ-on-chip (OOC) platforms have attracted attentions of pharmaceutical companies as powerful tools for screening of existing drugs and development of new drug candidates. OOCs have primarily used human cell lines or primary cells to develop biomimetic tissue models. However, the ability of human stem cells in unlimited self-renewal and differentiation into multiple lineages has made them attractive for OOCs. The microfluidic technology has enabled precise control of stem cell differentiation using soluble factors, biophysical cues, and electromagnetic signals. This study discusses different tissue- and organ-on-chip platforms (i.e., skin, brain, blood-brain barrier, bone marrow, heart, liver, lung, tumor, and vascular), with an emphasis on the critical role of stem cells in the synthesis of complex tissues. This study further recaps the design, fabrication, high-throughput performance, and improved functionality of stem-cell-based OOCs, technical challenges, obstacles against implementing their potential applications, and future perspectives related to different experimental platforms. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Framework Programmable Platform for the advanced software development workstation: Framework processor design document

NASA Technical Reports Server (NTRS)

Mayer, Richard J.; Blinn, Thomas M.; Mayer, Paula S. D.; Ackley, Keith A.; Crump, Wes; Sanders, Les

1991-01-01

The design of the Framework Processor (FP) component of the Framework Programmable Software Development Platform (FFP) is described. The FFP is a project aimed at combining effective tool and data integration mechanisms with a model of the software development process in an intelligent integrated software development environment. Guided by the model, this Framework Processor will take advantage of an integrated operating environment to provide automated support for the management and control of the software development process so that costly mistakes during the development phase can be eliminated.

ADMS Evaluation Platform

DOE Office of Scientific and Technical Information (OSTI.GOV)

2018-01-23

Deploying an ADMS or looking to optimize its value? NREL offers a low-cost, low-risk evaluation platform for assessing ADMS performance. The National Renewable Energy Laboratory (NREL) has developed a vendor-neutral advanced distribution management system (ADMS) evaluation platform and is expanding its capabilities. The platform uses actual grid-scale hardware, large-scale distribution system models, and advanced visualization to simulate realworld conditions for the most accurate ADMS evaluation and experimentation.

Development of novel microfluidic platforms for neural stem cell research

NASA Astrophysics Data System (ADS)

Chung, Bonggeun

This dissertation describes the development and characterization of novel microfluidic platforms to study proliferation, differentiation, migration, and apoptosis of neural stem cells (NSCs). NSCs hold tremendous promise for fundamental biological studies and cell-based therapies in human disorders. NSCs are defined as cells that can self-renew yet maintain the ability to generate the three principal cell types of the central nervous system such as neurons, astrocytes, and oligodendrocytes. NSCs therefore have therapeutic possibilities in multiple neurodevelopmental and neurodegenerative diseases. Despite their promise, cell-based therapies are limited by the inability to precisely control their behavior in culture. Compared to traditional culture tools, microfluidic platforms can provide much greater control over cell microenvironments and optimize proliferation and differentiation conditions of cells exposed to combinatorial mixtures of growth factors. Human NSCs were cultured for more than 1 week in the microfluidic device while constantly exposed to a continuous gradient of a growth factor mixture. NSCs proliferated and differentiated in a graded and proportional fashion that varied directly with growth factor concentration. In parallel to the study of growth and differentiation of NSCs, we are interested in proliferation and apoptosis of mouse NSCs exposed to morphogen gradients. Morphogen gradients are fundamental to animal brain development. Nonetheless, much controversy remains about the mechanisms by which morphogen gradients act on the developing brain. To overcome limitations of in-vitro models of gradients, we have developed a hybrid microfluidic platform that can mimic morphogen gradient profiles. Bone morphogenetic protein (BMP) activity in the developing cortex is graded and cortical NSC responses to BMPs are highly dependent on concentration and gradient slope of BMPs. To make novel microfluidic devices integrated with multiple functions, we have

A Software Development Platform for Wearable Medical Applications.

PubMed

Zhang, Ruikai; Lin, Wei

2015-10-01

Wearable medical devices have become a leading trend in healthcare industry. Microcontrollers are computers on a chip with sufficient processing power and preferred embedded computing units in those devices. We have developed a software platform specifically for the design of the wearable medical applications with a small code footprint on the microcontrollers. It is supported by the open source real time operating system FreeRTOS and supplemented with a set of standard APIs for the architectural specific hardware interfaces on the microcontrollers for data acquisition and wireless communication. We modified the tick counter routine in FreeRTOS to include a real time soft clock. When combined with the multitasking features in the FreeRTOS, the platform offers the quick development of wearable applications and easy porting of the application code to different microprocessors. Test results have demonstrated that the application software developed using this platform are highly efficient in CPU usage while maintaining a small code foot print to accommodate the limited memory space in microcontrollers.

Development of a 3D patient-specific planning platform for interstitial and transurethral ultrasound thermal therapy

NASA Astrophysics Data System (ADS)

Prakash, Punit; Diederich, Chris J.

2010-03-01

Interstitial and transurethral catheter-based ultrasound devices are under development for treatment of prostate cancer and BPH, uterine fibroids, liver tumors and other soft tissue disease. Accurate 3D thermal modeling is essential for designing site-specific applicators, exploring treatment delivery strategies, and integration of patient-specific treatment planning of thermal ablations. We are developing a comprehensive 3D modeling and treatment planning platform for ultrasound ablation of tissue using catheter-based applicators. We explored the applicability of assessing thermal effects in tissue using critical temperature, thermal dose and Arrhenius thermal damage thresholds and performed a comparative analysis of dynamic tissue properties critical to accurate modeling. We used the model to assess the feasibility of automatic feedback control with MR thermometry, and demonstrated the utility of the modeling platform for 3D patient-specific treatment planning. We have identified critical temperature, thermal dose and thermal damage thresholds for assessing treatment endpoint. Dynamic changes in tissue attenuation/absorption and perfusion must be included for accurate prediction of temperature profiles and extents of the ablation zone. Lastly, we demonstrated use of the modeling platform for patient-specific treatment planning.

Model Developments for Development of Improved Emissions Scenarios: Developing Purchasing-Power Parity Models, Analyzing Uncertainty, and Developing Data Sets for Gridded Integrated Assessment Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Zili; Nordhaus, William

2009-03-19

In the duration of this project, we finished the main tasks set up in the initial proposal. These tasks include: setting up the basic platform in GAMS language for the new RICE 2007 model; testing various model structure of RICE 2007; incorporating PPP data set in the new RICE model; developing gridded data set for IA modeling.

3D-Lab: a collaborative web-based platform for molecular modeling.

PubMed

Grebner, Christoph; Norrby, Magnus; Enström, Jonatan; Nilsson, Ingemar; Hogner, Anders; Henriksson, Jonas; Westin, Johan; Faramarzi, Farzad; Werner, Philip; Boström, Jonas

2016-09-01

The use of 3D information has shown impact in numerous applications in drug design. However, it is often under-utilized and traditionally limited to specialists. We want to change that, and present an approach making 3D information and molecular modeling accessible and easy-to-use 'for the people'. A user-friendly and collaborative web-based platform (3D-Lab) for 3D modeling, including a blazingly fast virtual screening capability, was developed. 3D-Lab provides an interface to automatic molecular modeling, like conformer generation, ligand alignments, molecular dockings and simple quantum chemistry protocols. 3D-Lab is designed to be modular, and to facilitate sharing of 3D-information to promote interactions between drug designers. Recent enhancements to our open-source virtual reality tool Molecular Rift are described. The integrated drug-design platform allows drug designers to instantaneously access 3D information and readily apply advanced and automated 3D molecular modeling tasks, with the aim to improve decision-making in drug design projects.

Integrative structure modeling with the Integrative Modeling Platform.

PubMed

Webb, Benjamin; Viswanath, Shruthi; Bonomi, Massimiliano; Pellarin, Riccardo; Greenberg, Charles H; Saltzberg, Daniel; Sali, Andrej

2018-01-01

Building models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological systems work, evolved, might be controlled, and even designed. Integrative structure modeling casts the building of structural models as a computational optimization problem, for which information about the assembly is encoded into a scoring function that evaluates candidate models. Here, we describe our open source software suite for integrative structure modeling, Integrative Modeling Platform (https://integrativemodeling.org), and demonstrate its use. © 2017 The Protein Society.

Floating production platforms and their applications in the development of oil and gas fields in the South China Sea

NASA Astrophysics Data System (ADS)

Zhang, Dagang; Chen, Yongjun; Zhang, Tianyu

2014-03-01

This paper studies the current available options for floating production platforms in developing deepwater oil fields and the potential development models of future oil and gas exploration in the South China Sea. A detailed review of current deepwater platforms worldwide was performed through the examples of industry projects, and the pros and cons of each platform are discussed. Four types of platforms are currently used for the deepwater development: tension leg platform, Spar, semi-submersible platform, and the floating production system offloading. Among these, the TLP and Spar can be used for dry tree applications, and have gained popularity in recent years. The dry tree application enables the extension of the drilling application for fixed platforms into floating systems, and greatly reduces the cost and complexity of the subsea operation. Newly built wet tree semi-submersible production platforms for ultra deepwater are also getting their application, mainly due to the much needed payload for deepwater making the conversion of the old drilling semi-submersible platforms impossible. These platforms have been used in different fields around the world for different environments; each has its own advantages and disadvantages. There are many challenges with the successful use of these floating platforms. A lot of lessons have been learned and extensive experience accumulated through the many project applications. Key technologies are being reviewed for the successful use of floating platforms for field development, and potential future development needs are being discussed. Some of the technologies and experience of platform applications can be well used for the development of the South China Sea oil and gas field.

DPOI: Distributed software system development platform for ocean information service

NASA Astrophysics Data System (ADS)

Guo, Zhongwen; Hu, Keyong; Jiang, Yongguo; Sun, Zhaosui

2015-02-01

Ocean information management is of great importance as it has been employed in many areas of ocean science and technology. However, the developments of Ocean Information Systems (OISs) often suffer from low efficiency because of repetitive work and continuous modifications caused by dynamic requirements. In this paper, the basic requirements of OISs are analyzed first, and then a novel platform DPOI is proposed to improve development efficiency and enhance software quality of OISs by providing off-the-shelf resources. In the platform, the OIS is decomposed hierarchically into a set of modules, which can be reused in different system developments. These modules include the acquisition middleware and data loader that collect data from instruments and files respectively, the database that stores data consistently, the components that support fast application generation, the web services that make the data from distributed sources syntactical by use of predefined schemas and the configuration toolkit that enables software customization. With the assistance of the development platform, the software development needs no programming and the development procedure is thus accelerated greatly. We have applied the development platform in practical developments and evaluated its efficiency in several development practices and different development approaches. The results show that DPOI significantly improves development efficiency and software quality.

Development of embedded real-time and high-speed vision platform

NASA Astrophysics Data System (ADS)

Ouyang, Zhenxing; Dong, Yimin; Yang, Hua

2015-12-01

Currently, high-speed vision platforms are widely used in many applications, such as robotics and automation industry. However, a personal computer (PC) whose over-large size is not suitable and applicable in compact systems is an indispensable component for human-computer interaction in traditional high-speed vision platforms. Therefore, this paper develops an embedded real-time and high-speed vision platform, ER-HVP Vision which is able to work completely out of PC. In this new platform, an embedded CPU-based board is designed as substitution for PC and a DSP and FPGA board is developed for implementing image parallel algorithms in FPGA and image sequential algorithms in DSP. Hence, the capability of ER-HVP Vision with size of 320mm x 250mm x 87mm can be presented in more compact condition. Experimental results are also given to indicate that the real-time detection and counting of the moving target at a frame rate of 200 fps at 512 x 512 pixels under the operation of this newly developed vision platform are feasible.

Semantic Web Infrastructure Supporting NextFrAMES Modeling Platform

NASA Astrophysics Data System (ADS)

Lakhankar, T.; Fekete, B. M.; Vörösmarty, C. J.

2008-12-01

Emerging modeling frameworks offer new ways to modelers to develop model applications by offering a wide range of software components to handle common modeling tasks such as managing space and time, distributing computational tasks in parallel processing environment, performing input/output and providing diagnostic facilities. NextFrAMES, the next generation updates to the Framework for Aquatic Modeling of the Earth System originally developed at University of New Hampshire and currently hosted at The City College of New York takes a step further by hiding most of these services from modeler behind a platform agnostic modeling platform that allows scientists to focus on the implementation of scientific concepts in the form of a new modeling markup language and through a minimalist application programming interface that provide means to implement model processes. At the core of the NextFrAMES modeling platform there is a run-time engine that interprets the modeling markup language loads the module plugins establishes the model I/O and executes the model defined by the modeling XML and the accompanying plugins. The current implementation of the run-time engine is designed for single processor or symmetric multi processing (SMP) systems but future implementation of the run-time engine optimized for different hardware architectures are anticipated. The modeling XML and the accompanying plugins define the model structure and the computational processes in a highly abstract manner, which is not only suitable for the run-time engine, but has the potential to integrate into semantic web infrastructure, where intelligent parsers can extract information about the model configurations such as input/output requirements applicable space and time scales and underlying modeling processes. The NextFrAMES run-time engine itself is also designed to tap into web enabled data services directly, therefore it can be incorporated into complex workflow to implement End-to-End application

Developing the concept of a geostationary platform. [for communication services

NASA Technical Reports Server (NTRS)

Carey, W. T.; Bowman, R. M.; Stone, G. R.

1980-01-01

A geostationary platform concept with a proliferation of low-cost earth stations is discussed. Candidate platform concepts, servicing, life, and Orbital Transfer Vehicle (OTV) options are considered. A Life Cycle Costing model is used to select the minimum cost concept meeting program criteria. It is concluded that the geostationary platform concept is a practical and economical approach to providing expanding communication services within the limitations imposed by the available frequency spectrum and orbital arc.

Design and development of a prototype platform for gait analysis

NASA Astrophysics Data System (ADS)

Diffenbaugh, T. E.; Marti, M. A.; Jagani, J.; Garcia, V.; Iliff, G. J.; Phoenix, A.; Woolard, A. G.; Malladi, V. V. N. S.; Bales, D. B.; Tarazaga, P. A.

2017-04-01

The field of event classification and localization in building environments using accelerometers has grown significantly due to its implications for energy, security, and emergency protocols. Virginia Tech's Goodwin Hall (VT-GH) provides a robust testbed for such work, but a reduced scale testbed could provide significant benefits by allowing algorithm development to occur in a simplified environment. Environments such as VT-GH have high human traffic that contributes external noise disrupting test signals. This paper presents a design solution through the development of an isolated platform for data collection, portable demonstrations, and the development of localization and classification algorithms. The platform's success was quantified by the resulting transmissibility of external excitation sources, demonstrating the capabilities of the platform to isolate external disturbances while preserving gait information. This platform demonstrates the collection of high-quality gait information in otherwise noisy environments for data collection or demonstration purposes.

Carbonate Platform Development and Stromatolite Morphogenesis: Constraints on Environmental and Biological Evolution

NASA Technical Reports Server (NTRS)

Grotzinger, John P.

2003-01-01

Work has been completed on the digital mapping of a terminal Proterozoic reef complex in Namibia. This complex formed an isolated carbonate platform developed downdip on a carbonate ramp of the Nama Group. The stratigraphic evolution of the platform was digitally reconstructed from an extensive dataset that was compiled by using digital surveying technologies. The platform comprises three accommodation cycles in which each subsequent cycle experienced progressively greater influence of a long-term accommodation increase. Aggradation and progradation during the first cycle resulted in a flat, uniform, sheet-like platform. The coarsening and shallowing-upward sequence representing the first cycle is dominated by columnar stromatolitic thrombolites and massive dolostones with interbedded mudstone-grainstone at the base of the sequence grading into cross-bedded dolostones. The second cycle features aggradation, formation of a distinct margin containing thrombolite mounds and domes, and the development of a bucket geometry. Columnar stromatolitic thrombolites dominate the platform interior. The final stage of platform development shows a deepening trend with initial aggradation and formation of well-bedded, thin deposits in the interior and mound development at the margins. While the interior drowned, the platform margin kept up with rising sea level and a complex pinnacle reef formed containing fused and coalesced thrombolite mounds flanked by bioclastic grainstones (containing Cloudina and Namacalathus fossils) and collapse breccias. A set of isolated large thrombolite mounds flanked by shales indicate the final stage of the carbonate platform. During a progressive increase in accommodation, a flat-topped isolated carbonate platform becomes aerially less extensive by either backstepping or formation of smaller pinnacles or a combination of both. The overall geometric evolution of the studied platform from flat-topped to bucket with elevated margins is recorded in many

Cross platform development using Delphi and Kylix

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, J.L.; Nishimura, H.; Timossi, C.

2002-10-08

A cross platform component for EPICS Simple Channel Access (SCA) has been developed for the use with Delphi on Windows and Kylix on Linux. An EPICS controls GUI application developed on Windows runs on Linux by simply rebuilding it, and vice versa. This paper describes the technical details of the component.

Digital Platforms as Factor Transforming Management Models in Businesses and Industries

NASA Astrophysics Data System (ADS)

Dimitrakiev, D.; Molodchik, A. V.

2018-05-01

Increasingly, digital platforms are built into the value chain, acting as an intermediary between the manufacturer and the consumer. The paper presents tendencies and features of business model transformation in connection with management of the new digital technologies. The limitations of traditional business models and the capabilities of business models based on digital platforms and self-organization were revealed. In the study, the viability of the new business model for the dental industry was confirmed and the new concept of the branch self-organizing control system based on the information platform, blockchain, cryptocurrency and reward of target consumer is offered, including mechanisms that make the model attractive for both the consumer and the service provider.

[Application of an improved model of a job-matching platform for nurses].

PubMed

Huang, Way-Ren; Lin, Chiou-Fen

2015-04-01

The three-month attrition rate for new nurses in Taiwan remains high. Many hospitals rely on traditional recruitment methods to find new nurses, yet it appears that their efficacy is less than ideal. To effectively solve this manpower shortage, a nursing resource platform is a project worth developing in the future. This study aimed to utilize a quality-improvement model to establish communication between hospitals and nursing students and create a customized employee-employer information-matching platform to help nursing students enter the workforce. This study was structured around a quality-improvement model and used current situation analysis, literature review, focus-group discussions, and process re-engineering to formulate necessary content for a job-matching platform for nursing. The concept of an academia-industry strategic alliance helped connect supply and demand within the same supply chain. The nurse job-matching platform created in this study provided job flexibility as well as job suitability assessments and continued follow-up and services for nurses after entering the workforce to provide more accurate matching of employers and employees. The academia-industry strategic alliance, job suitability, and long-term follow-up designed in this study are all new features in Taiwan's human resource service systems. The proposed human resource process re-engineering provides nursing students facing graduation with a professionally managed human resources platform. Allowing students to find an appropriate job prior to graduation will improve willingness to work and employee retention.

Creating a professional development platform to transform social work clinical practice in health care.

PubMed

Xenakis, Nancy

2018-07-01

Since U.S. Congress' 2010 passing of the Affordable Care Act and the creation of numerous care coordination programs, Mount Sinai Hospital's Department of Social Work Services has experienced exponential growth. The Department is deeply committed to recruiting and developing the most talented social workers to best meet the needs of patients and family caregivers and to serve as integral, valued members of interdisciplinary care teams. Traditional learning methods are insufficient for a staff of hundreds, given the changes in health care and the complexity of the work. This necessitates the use of new training and education methods to maintain the quality of professional development. This article provides an overview of the Department's strategy and creation of a professional development learning platform to transform clinical social work practice. It reviews various education models that utilize an e-learning management system and case studies using standardized patients. These models demonstrate innovative learning approaches for both new and experienced social workers in health care. The platform's successes and challenges and recommendations for future development and sustainability are outlined.

eTRIKS platform: Conception and operation of a highly scalable cloud-based platform for translational research and applications development.

PubMed

Bussery, Justin; Denis, Leslie-Alexandre; Guillon, Benjamin; Liu, Pengfeï; Marchetti, Gino; Rahal, Ghita

2018-04-01

We describe the genesis, design and evolution of a computing platform designed and built to improve the success rate of biomedical translational research. The eTRIKS project platform was developed with the aim of building a platform that can securely host heterogeneous types of data and provide an optimal environment to run tranSMART analytical applications. Many types of data can now be hosted, including multi-OMICS data, preclinical laboratory data and clinical information, including longitudinal data sets. During the last two years, the platform has matured into a robust translational research knowledge management system that is able to host other data mining applications and support the development of new analytical tools. Copyright © 2018 Elsevier Ltd. All rights reserved.

Development of a computer model to predict platform station keeping requirements in the Gulf of Mexico using remote sensing data

NASA Technical Reports Server (NTRS)

Barber, Bryan; Kahn, Laura; Wong, David

1990-01-01

Offshore operations such as oil drilling and radar monitoring require semisubmersible platforms to remain stationary at specific locations in the Gulf of Mexico. Ocean currents, wind, and waves in the Gulf of Mexico tend to move platforms away from their desired locations. A computer model was created to predict the station keeping requirements of a platform. The computer simulation uses remote sensing data from satellites and buoys as input. A background of the project, alternate approaches to the project, and the details of the simulation are presented.

Development of an IHE MRRT-compliant open-source web-based reporting platform.

PubMed

Pinto Dos Santos, Daniel; Klos, G; Kloeckner, R; Oberle, R; Dueber, C; Mildenberger, P

2017-01-01

To develop a platform that uses structured reporting templates according to the IHE Management of Radiology Report Templates (MRRT) profile, and to implement this platform into clinical routine. The reporting platform uses standard web technologies (HTML / JavaScript and PHP / MySQL) only. Several freely available external libraries were used to simplify the programming. The platform runs on a standard web server, connects with the radiology information system (RIS) and PACS, and is easily accessible via a standard web browser. A prototype platform that allows structured reporting to be easily incorporated into the clinical routine was developed and successfully tested. To date, 797 reports were generated using IHE MRRT-compliant templates (many of them downloaded from the RSNA's radreport.org website). Reports are stored in a MySQL database and are easily accessible for further analyses. Development of an IHE MRRT-compliant platform for structured reporting is feasible using only standard web technologies. All source code will be made available upon request under a free license, and the participation of other institutions in further development is welcome. • A platform for structured reporting using IHE MRRT-compliant templates is presented. • Incorporating structured reporting into clinical routine is feasible. • Full source code will be provided upon request under a free license.

Progress in Development of the ITER Plasma Control System Simulation Platform

NASA Astrophysics Data System (ADS)

Walker, Michael; Humphreys, David; Sammuli, Brian; Ambrosino, Giuseppe; de Tommasi, Gianmaria; Mattei, Massimiliano; Raupp, Gerhard; Treutterer, Wolfgang; Winter, Axel

2017-10-01

We report on progress made and expected uses of the Plasma Control System Simulation Platform (PCSSP), the primary test environment for development of the ITER Plasma Control System (PCS). PCSSP will be used for verification and validation of the ITER PCS Final Design for First Plasma, to be completed in 2020. We discuss the objectives of PCSSP, its overall structure, selected features, application to existing devices, and expected evolution over the lifetime of the ITER PCS. We describe an archiving solution for simulation results, methods for incorporating physics models of the plasma and physical plant (tokamak, actuator, and diagnostic systems) into PCSSP, and defining characteristics of models suitable for a plasma control development environment such as PCSSP. Applications of PCSSP simulation models including resistive plasma equilibrium evolution are demonstrated. PCSSP development supported by ITER Organization under ITER/CTS/6000000037. Resistive evolution code developed under General Atomics' Internal funding. The views and opinions expressed herein do not necessarily reflect those of the ITER Organization.

3D shape measurement system developed on mobile platform

NASA Astrophysics Data System (ADS)

Wu, Zhoujie; Chang, Meng; Shi, Bowen; Zhang, Qican

2017-02-01

Three-dimensional (3-D) shape measurement technology based on structured light has become one hot research field inspired by the increasing requirements. Many methods have been implemented and applied in the industry applications, but most of their equipments are large and complex, cannot be portable. Meanwhile, the popularity of the smart mobile terminals, such as smart phones, provides a platform for the miniaturization and portability of this technology. The measurement system based on phase-shift algorithm and Gray-code pattern under the Android platform on a mobile phone is mainly studied and developed, and it has been encapsulated into a mobile phone application in order to reconstruct 3-D shape data in the employed smart phone easily and quickly. The experimental results of two measured object are given in this paper and demonstrate the application we developed in the mobile platform is effective.

An Open Software Platform for Sharing Water Resource Models, Code and Data

NASA Astrophysics Data System (ADS)

Knox, Stephen; Meier, Philipp; Mohamed, Khaled; Korteling, Brett; Matrosov, Evgenii; Huskova, Ivana; Harou, Julien; Rosenberg, David; Tilmant, Amaury; Medellin-Azuara, Josue; Wicks, Jon

2016-04-01

The modelling of managed water resource systems requires new approaches in the face of increasing future uncertainty. Water resources management models, even if applied to diverse problem areas, use common approaches such as representing the problem as a network of nodes and links. We propose a data management software platform, called Hydra, that uses this commonality to allow multiple models using a node-link structure to be managed and run using a single software system. Hydra's user interface allows users to manage network topology and associated data. Hydra feeds this data directly into a model, importing from and exporting to different file formats using Apps. An App connects Hydra to a custom model, a modelling system such as GAMS or MATLAB or to different file formats such as MS Excel, CSV and ESRI Shapefiles. Hydra allows users to manage their data in a single, consistent place. Apps can be used to run domain-specific models and allow users to work with their own required file formats. The Hydra App Store offers a collaborative space where model developers can publish, review and comment on Apps, models and data. Example Apps and open-source libraries are available in a variety of languages (Python, Java and .NET). The App Store can act as a hub for water resource modellers to view and share Apps, models and data easily. This encourages an ecosystem of development using a shared platform, resulting in more model integration and potentially greater unity within resource modelling communities. www.hydraplatform.org www.hydraappstore.com

A Model Collaborative Platform for Geoscience Education

NASA Astrophysics Data System (ADS)

Fox, S.; Manduca, C. A.; Iverson, E. A.

2012-12-01

Over the last decade SERC at Carleton College has developed a collaborative platform for geoscience education that has served dozens of projects, thousands of community authors and millions of visitors. The platform combines a custom technical infrastructure: the SERC Content Management system (CMS), and a set of strategies for building web-resources that can be disseminated through a project site, reused by other projects (with attribution) or accessed via an integrated geoscience education resource drawing from all projects using the platform. The core tools of the CMS support geoscience education projects in building project-specific websites. Each project uses the CMS to engage their specific community in collecting, authoring and disseminating the materials of interest to them. At the same time the use of a shared central infrastructure allows cross-fertilization among these project websites. Projects are encouraged to use common templates and common controlled vocabularies for organizing and displaying their resources. This standardization is then leveraged through cross-project search indexing which allow projects to easily incorporate materials from other projects within their own collection in ways that are relevant and automated. A number of tools are also in place to help visitors move among project websites based on their personal interests. Related links help visitors discover content related topically to their current location that is in a 'separate' project. A 'best bets' feature in search helps guide visitors to pages that are good starting places to explore resources on a given topic across the entire range of hosted projects. In many cases these are 'site guide' pages created specifically to promote a cross-project view of the available resources. In addition to supporting the cross-project exploration of specific themes the CMS also allows visitors to view the combined suite of resources authored by any particular community member. Automatically

Reusable Component Model Development Approach for Parallel and Distributed Simulation

PubMed Central

Zhu, Feng; Yao, Yiping; Chen, Huilong; Yao, Feng

2014-01-01

Model reuse is a key issue to be resolved in parallel and distributed simulation at present. However, component models built by different domain experts usually have diversiform interfaces, couple tightly, and bind with simulation platforms closely. As a result, they are difficult to be reused across different simulation platforms and applications. To address the problem, this paper first proposed a reusable component model framework. Based on this framework, then our reusable model development approach is elaborated, which contains two phases: (1) domain experts create simulation computational modules observing three principles to achieve their independence; (2) model developer encapsulates these simulation computational modules with six standard service interfaces to improve their reusability. The case study of a radar model indicates that the model developed using our approach has good reusability and it is easy to be used in different simulation platforms and applications. PMID:24729751

A neurorobotic platform for locomotor prosthetic development in rats and mice

NASA Astrophysics Data System (ADS)

von Zitzewitz, Joachim; Asboth, Leonie; Fumeaux, Nicolas; Hasse, Alexander; Baud, Laetitia; Vallery, Heike; Courtine, Grégoire

2016-04-01

Objectives. We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice. Approach. We interfaced a large-scale robotic structure actuated in four degrees of freedom to exchangeable attachment modules exhibiting selective compliance along distinct directions. This combination allowed high-precision force and torque control in multiple directions over a large workspace. We next designed a neurorobotic platform wherein real-time kinematics and physiological signals directly adjust robotic actuation and prosthetic actions. We tested the performance of this platform in both rats and mice with spinal cord injury. Main Results. Kinematic analyses showed that the robotic interface did not impede locomotor movements of lightweight mice that walked freely along paths with changing directions and height profiles. Personalized trunk assistance instantly enabled coordinated locomotion in mice and rats with severe hindlimb motor deficits. Closed-loop control of robotic actuation based on ongoing movement features enabled real-time control of electromyographic activity in anti-gravity muscles during locomotion. Significance. This neurorobotic platform will support the study of the mechanisms underlying the therapeutic effects of locomotor prosthetics and rehabilitation using high-resolution genetic tools in rodent models.

A neurorobotic platform for locomotor prosthetic development in rats and mice.

PubMed

von Zitzewitz, Joachim; Asboth, Leonie; Fumeaux, Nicolas; Hasse, Alexander; Baud, Laetitia; Vallery, Heike; Courtine, Grégoire

2016-04-01

We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice. We interfaced a large-scale robotic structure actuated in four degrees of freedom to exchangeable attachment modules exhibiting selective compliance along distinct directions. This combination allowed high-precision force and torque control in multiple directions over a large workspace. We next designed a neurorobotic platform wherein real-time kinematics and physiological signals directly adjust robotic actuation and prosthetic actions. We tested the performance of this platform in both rats and mice with spinal cord injury. Kinematic analyses showed that the robotic interface did not impede locomotor movements of lightweight mice that walked freely along paths with changing directions and height profiles. Personalized trunk assistance instantly enabled coordinated locomotion in mice and rats with severe hindlimb motor deficits. Closed-loop control of robotic actuation based on ongoing movement features enabled real-time control of electromyographic activity in anti-gravity muscles during locomotion. This neurorobotic platform will support the study of the mechanisms underlying the therapeutic effects of locomotor prosthetics and rehabilitation using high-resolution genetic tools in rodent models.

Rapid Development of Bespoke Unmanned Platforms for Atmospheric Science

NASA Astrophysics Data System (ADS)

Sobester, A.; Johnston, S. J.; Scanlan, J. P.; Hart, E. E.; O'Brien, N. S.

2012-04-01

The effective deployment of airborne atmospheric science instruments often hinges on the development cycle time of a suitable platform, one that is capable of delivering them to the desired altitude range for a specified amount of time, along a pre-determined trajectory. This could be driven by the need to respond rapidly to sudden, unexpected events (e.g., volcano eruptions, nuclear fallout, etc.) or simply to accommodate the iterative design and flight test cycle of the instrument developer. A shorter development cycle time would also afford us the ability to quickly adapt the hardware and control logic in response to unexpected results during an experimental campaign. We report on recent developments aimed at meeting this demand. As part of the Atmospheric Science Through Robotic Aircraft (ASTRA) initiative we have investigated the use of rapid prototyping technologies to this end, both on the 'airframe' of the platform itself and on the on-board systems. We show how fast multi-disciplinary design optimization techniques, coupled with computer-controlled additive manufacturing (3D printing) and laser cutting methods and electronic prototyping (using standard, modular, programmable building blocks) can lead to the delivery of a fully customized platform integrating a given instrument in a timescale of the order of ten days. Specific examples include the design and testing of a balloon-launched glider sensorcraft and a stratospheric balloon system. The 'vehicle' for the latter was built on a 3D printer using a copolymer thermoplastic material and fitted with a sacrificial protective 'cage' laser-cut from an open-cell foam. The data logging, tracking, sensor integration and communications services of the platform were constructed using the .net Gadgeteer open source hardware kit. The flight planning and eventual post-flight recovery of the system is enabled by a generic, stochastic trajectory simulation tool, also developed as part of the ASTRA initiative. This

78 FR 70935 - Notice of Availability of the Environmental Protection Agency's 2011 Emissions Modeling Platform

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... alternative data sets. II. Information Available for Public Comment The 2011 Emissions Modeling Platform... Assessment. The EPA has placed key information related to the 2011 emissions modeling platform into the... the Environmental Protection Agency's 2011 Emissions Modeling Platform AGENCY: Environmental...

Modeling and control of flexible space platforms with articulated payloads

NASA Technical Reports Server (NTRS)

Graves, Philip C.; Joshi, Suresh M.

1989-01-01

The first steps in developing a methodology for spacecraft control-structure interaction (CSI) optimization are identification and classification of anticipated missions, and the development of tractable mathematical models in each mission class. A mathematical model of a generic large flexible space platform (LFSP) with multiple independently pointed rigid payloads is considered. The objective is not to develop a general purpose numerical simulation, but rather to develop an analytically tractable mathematical model of such composite systems. The equations of motion for a single payload case are derived, and are linearized about zero steady-state. The resulting model is then extended to include multiple rigid payloads, yielding the desired analytical form. The mathematical models developed clearly show the internal inertial/elastic couplings, and are therefore suitable for analytical and numerical studies. A simple decentralized control law is proposed for fine pointing the payloads and LFSP attitude control, and simulation results are presented for an example problem. The decentralized controller is shown to be adequate for the example problem chosen, but does not, in general, guarantee stability. A centralized dissipative controller is then proposed, requiring a symmetric form of the composite system equations. Such a controller guarantees robust closed loop stability despite unmodeled elastic dynamics and parameter uncertainties.

An overview on development and application of an experimental platform for quantitative cardiac imaging research in rabbit models of myocardial infarction

PubMed Central

Feng, Yuanbo; Bogaert, Jan; Oyen, Raymond

2014-01-01

To exploit the advantages of using rabbits for cardiac imaging research and to tackle the technical obstacles, efforts have been made under the framework of a doctoral research program. In this overview article, by cross-referencing the current literature, we summarize how we have developed a preclinical cardiac research platform based on modified models of reperfused myocardial infarction (MI) in rabbits; how the in vivo manifestations of cardiac imaging could be closely matched with those ex vivo macro- and microscopic findings; how these imaging outcomes could be quantitatively analyzed, validated and demonstrated; and how we could apply this cardiac imaging platform to provide possible solutions to certain lingering diagnostic and therapeutic problems in experimental cardiology. In particular, tissue components in acute cardiac ischemia have been stratified and characterized, post-infarct lipomatous metaplasia (LM) as a common but hardly illuminated clinical pathology has been identified in rabbit models, and a necrosis avid tracer as well as an anti-ischemic drug have been successfully assessed for their potential utilities in clinical cardiology. These outcomes may interest the researchers in the related fields and help strengthen translational research in cardiovascular diseases. PMID:25392822

An overview on development and application of an experimental platform for quantitative cardiac imaging research in rabbit models of myocardial infarction.

PubMed

Feng, Yuanbo; Bogaert, Jan; Oyen, Raymond; Ni, Yicheng

2014-10-01

To exploit the advantages of using rabbits for cardiac imaging research and to tackle the technical obstacles, efforts have been made under the framework of a doctoral research program. In this overview article, by cross-referencing the current literature, we summarize how we have developed a preclinical cardiac research platform based on modified models of reperfused myocardial infarction (MI) in rabbits; how the in vivo manifestations of cardiac imaging could be closely matched with those ex vivo macro- and microscopic findings; how these imaging outcomes could be quantitatively analyzed, validated and demonstrated; and how we could apply this cardiac imaging platform to provide possible solutions to certain lingering diagnostic and therapeutic problems in experimental cardiology. In particular, tissue components in acute cardiac ischemia have been stratified and characterized, post-infarct lipomatous metaplasia (LM) as a common but hardly illuminated clinical pathology has been identified in rabbit models, and a necrosis avid tracer as well as an anti-ischemic drug have been successfully assessed for their potential utilities in clinical cardiology. These outcomes may interest the researchers in the related fields and help strengthen translational research in cardiovascular diseases.

Learning by Doing: How to Develop a Cross-Platform Web App

ERIC Educational Resources Information Center

Huynh, Minh; Ghimire, Prashant

2015-01-01

As mobile devices become prevalent, there is always a need for apps. How hard is it to develop an app, especially a cross-platform app? The paper shares an experience in a project that involved the development of a student services web app that can be run on cross-platform mobile devices. The paper first describes the background of the project,…

A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells

PubMed Central

Guarnerio, Jlenia; Riccardi, Luisa; Taulli, Riccardo; Maeda, Takahiro; Wang, Guocan; Hobbs, Robin M.; Song, Min Sup; Sportoletti, Paolo; Bernardi, Rosa; Bronson, Roderick T.; Castillo-Martin, Mireia; Cordon-Cardo, Carlos; Lunardi, Andrea; Pandolfi, Pier Paolo

2015-01-01

The regulatory factors governing adult mesenchymal stem cells (MSCs) physiology and their tumorigenic potential are still largely unknown, which substantially delays the identification of effective therapeutic approaches for the treatment of aggressive and lethal form of MSC-derived mesenchymal tumors, such as undifferentiated sarcomas. Here we have developed a novel platform to screen and quickly identify genes and pathways responsible for adult MSCs transformation, modeled undifferentiated sarcoma in vivo, and, ultimately, tested the efficacy of targeting the identified oncopathways. Importantly, by taking advantage of this new platform, we demonstrate the key role of an aberrant LRF-DLK1-SOX9 pathway in the pathogenesis of undifferentiated sarcoma with important therapeutic implications. PMID:25614485

Developing a Hybrid Virtualization Platform Design for Cyber Warfare Training and Education

DTIC Science & Technology

2010-06-01

CYBER WARFARE TRAINING AND EDUCATION THESIS Kyle E. Stewart 2nd...Government. AFIT/GCE/ENG/10-06 DEVELOPING A HYBRID VIRTUALIZATION PLATFORM DESIGN FOR CYBER WARFARE TRAINING...APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. AFIT/GCE/ENG/10-06 DEVELOPING A HYBRID VIRTUALIZATION PLATFORM DESIGN FOR CYBER WARFARE

Development of jacket platform tsunami risk rating system in waters offshore North Borneo

NASA Astrophysics Data System (ADS)

Lee, H. E.; Liew, M. S.; Mardi, N. H.; Na, K. L.; Toloue, Iraj; Wong, S. K.

2016-09-01

This work details the simulation of tsunami waves generated by seaquakes in the Manila Trench and their effect on fixed oil and gas jacket platforms in waters offshore North Borneo. For this study, a four-leg living quarter jacket platform located in a water depth of 63m is modelled in SACS v5.3. Malaysia has traditionally been perceived to be safe from the hazards of earthquakes and tsunamis. Local design practices tend to neglect tsunami waves and include no such provisions. In 2004, a 9.3 M w seaquake occurred off the northwest coast of Aceh, which generated tsunami waves that caused destruction in Malaysia totalling US 25 million and 68 deaths. This event prompted an awareness of the need to study the reliability of fixed offshore platforms scattered throughout Malaysian waters. In this paper, we present a review of research on the seismicity of the Manila Trench, which is perceived to be high risk for Southeast Asia. From the tsunami numerical model TUNA-M2, we extract computer-simulated tsunami waves at prescribed grid points in the vicinity of the platforms in the region. Using wave heights as input, we simulate the tsunami using SACS v5.3 structural analysis software of offshore platforms, which is widely accepted by the industry. We employ the nonlinear solitary wave theory in our tsunami loading calculations for the platforms, and formulate a platform-specific risk quantification system. We then perform an intensive structural sensitivity analysis and derive a corresponding platform-specific risk rating model.

Equity venture capital platform model based on complex network

NASA Astrophysics Data System (ADS)

Guo, Dongwei; Zhang, Lanshu; Liu, Miao

2018-05-01

This paper uses the small-world network and the random-network to simulate the relationship among the investors, construct the network model of the equity venture capital platform to explore the impact of the fraud rate and the bankruptcy rate on the robustness of the network model while observing the impact of the average path length and the average agglomeration coefficient of the investor relationship network on the income of the network model. The study found that the fraud rate and bankruptcy rate exceeded a certain threshold will lead to network collapse; The bankruptcy rate has a great influence on the income of the platform; The risk premium exists, and the average return is better under a certain range of bankruptcy risk; The structure of the investor relationship network has no effect on the income of the investment model.

Using the Eclipse Parallel Tools Platform to Assist Earth Science Model Development and Optimization on High Performance Computers

NASA Astrophysics Data System (ADS)

Alameda, J. C.

2011-12-01

Development and optimization of computational science models, particularly on high performance computers, and with the advent of ubiquitous multicore processor systems, practically on every system, has been accomplished with basic software tools, typically, command-line based compilers, debuggers, performance tools that have not changed substantially from the days of serial and early vector computers. However, model complexity, including the complexity added by modern message passing libraries such as MPI, and the need for hybrid code models (such as openMP and MPI) to be able to take full advantage of high performance computers with an increasing core count per shared memory node, has made development and optimization of such codes an increasingly arduous task. Additional architectural developments, such as many-core processors, only complicate the situation further. In this paper, we describe how our NSF-funded project, "SI2-SSI: A Productive and Accessible Development Workbench for HPC Applications Using the Eclipse Parallel Tools Platform" (WHPC) seeks to improve the Eclipse Parallel Tools Platform, an environment designed to support scientific code development targeted at a diverse set of high performance computing systems. Our WHPC project to improve Eclipse PTP takes an application-centric view to improve PTP. We are using a set of scientific applications, each with a variety of challenges, and using PTP to drive further improvements to both the scientific application, as well as to understand shortcomings in Eclipse PTP from an application developer perspective, to drive our list of improvements we seek to make. We are also partnering with performance tool providers, to drive higher quality performance tool integration. We have partnered with the Cactus group at Louisiana State University to improve Eclipse's ability to work with computational frameworks and extremely complex build systems, as well as to develop educational materials to incorporate into

Development of a Web-Based Visualization Platform for Climate Research Using Google Earth

NASA Technical Reports Server (NTRS)

Sun, Xiaojuan; Shen, Suhung; Leptoukh, Gregory G.; Wang, Panxing; Di, Liping; Lu, Mingyue

2011-01-01

Recently, it has become easier to access climate data from satellites, ground measurements, and models from various data centers, However, searching. accessing, and prc(essing heterogeneous data from different sources are very tim -consuming tasks. There is lack of a comprehensive visual platform to acquire distributed and heterogeneous scientific data and to render processed images from a single accessing point for climate studies. This paper. documents the design and implementation of a Web-based visual, interoperable, and scalable platform that is able to access climatological fields from models, satellites, and ground stations from a number of data sources using Google Earth (GE) as a common graphical interface. The development is based on the TCP/IP protocol and various data sharing open sources, such as OPeNDAP, GDS, Web Processing Service (WPS), and Web Mapping Service (WMS). The visualization capability of integrating various measurements into cE extends dramatically the awareness and visibility of scientific results. Using embedded geographic information in the GE, the designed system improves our understanding of the relationships of different elements in a four dimensional domain. The system enables easy and convenient synergistic research on a virtual platform for professionals and the general public, gr$tly advancing global data sharing and scientific research collaboration.

Model reference adaptive control for the azimuth-pointing system of a balloon-borne stabilized platform

NASA Technical Reports Server (NTRS)

Lubin, Philip M.; Tomizuka, Masayoshi; Chingcuanco, Alfredo O.; Meinhold, Peter R.

1991-01-01

A balloon-born stabilized platform has been developed for the remotely operated altitude-azimuth pointing of a millimeter wave telescope system. This paper presents a development and implementation of model reference adaptive control (MRAC) for the azimuth-pointing system of the stabilized platform. The primary goal of the controller is to achieve pointing rms better than 0.1 deg. Simulation results indicate that MRAC can achieve pointing rms better than 0.1 deg. Ground test results show pointing rms better than 0.03 deg. Data from the first flight at the National Scientific Balloon Facility (NSBF) Palestine, Texas show pointing rms better than 0.02 deg.

Adding Value to the Network: Exploring the Software as a Service and Platform as a Service Models for Mobile Operators

NASA Astrophysics Data System (ADS)

Gonçalves, Vânia

The environments of software development and software provision are shifting to Web-based platforms supported by Platform/Software as a Service (PaaS/SaaS) models. This paper will make the case that there is equally an opportunity for mobile operators to identify additional sources of revenue by exposing network functionalities through Web-based service platforms. By elaborating on the concepts, benefits and risks of SaaS and PaaS, several factors that should be taken into consideration in applying these models to the telecom world are delineated.

Model Fusion Tool - the Open Environmental Modelling Platform Concept

NASA Astrophysics Data System (ADS)

Kessler, H.; Giles, J. R.

2010-12-01

The vision of an Open Environmental Modelling Platform - seamlessly linking geoscience data, concepts and models to aid decision making in times of environmental change. Governments and their executive agencies across the world are facing increasing pressure to make decisions about the management of resources in light of population growth and environmental change. In the UK for example, groundwater is becoming a scarce resource for large parts of its most densely populated areas. At the same time river and groundwater flooding resulting from high rainfall events are increasing in scale and frequency and sea level rise is threatening the defences of coastal cities. There is also a need for affordable housing, improved transport infrastructure and waste disposal as well as sources of renewable energy and sustainable food production. These challenges can only be resolved if solutions are based on sound scientific evidence. Although we have knowledge and understanding of many individual processes in the natural sciences it is clear that a single science discipline is unable to answer the questions and their inter-relationships. Modern science increasingly employs computer models to simulate the natural, economic and human system. Management and planning requires scenario modelling, forecasts and ‘predictions’. Although the outputs are often impressive in terms of apparent accuracy and visualisation, they are inherently not suited to simulate the response to feedbacks from other models of the earth system, such as the impact of human actions. Geological Survey Organisations (GSO) are increasingly employing advances in Information Technology to visualise and improve their understanding of geological systems. Instead of 2 dimensional paper maps and reports many GSOs now produce 3 dimensional geological framework models and groundwater flow models as their standard output. Additionally the British Geological Survey have developed standard routines to link geological

Development of an optoelectronic holographic platform for otolaryngology applications

NASA Astrophysics Data System (ADS)

Harrington, Ellery; Dobrev, Ivo; Bapat, Nikhil; Flores, Jorge Mauricio; Furlong, Cosme; Rosowski, John; Cheng, Jeffery Tao; Scarpino, Chris; Ravicz, Michael

2010-08-01

In this paper, we present advances on our development of an optoelectronic holographic computing platform with the ability to quantitatively measure full-field-of-view nanometer-scale movements of the tympanic membrane (TM). These measurements can facilitate otologists' ability to study and diagnose hearing disorders in humans. The holographic platform consists of a laser delivery system and an otoscope. The control software, called LaserView, is written in Visual C++ and handles communication and synchronization between hardware components. It provides a user-friendly interface to allow viewing of holographic images with several tools to automate holography-related tasks and facilitate hardware communication. The software uses a series of concurrent threads to acquire images, control the hardware, and display quantitative holographic data at video rates and in two modes of operation: optoelectronic holography and lensless digital holography. The holographic platform has been used to perform experiments on several live and post-mortem specimens, and is to be deployed in a medical research environment with future developments leading to its eventual clinical use.

Integration of the virtual model of a Stewart platform with the avatar of a vehicle in a virtual reality

NASA Astrophysics Data System (ADS)

Herbuś, K.; Ociepka, P.

2016-08-01

The development of methods of computer aided design and engineering allows conducting virtual tests, among others concerning motion simulation of technical means. The paper presents a method of integrating an object in the form of a virtual model of a Stewart platform with an avatar of a vehicle moving in a virtual environment. The area of the problem includes issues related to the problem of fidelity of mapping the work of the analyzed technical mean. The main object of investigations is a 3D model of a Stewart platform, which is a subsystem of the simulator designated for driving learning for disabled persons. The analyzed model of the platform, prepared for motion simulation, was created in the “Motion Simulation” module of a CAD/CAE class system Siemens PLM NX. Whereas the virtual environment, in which the moves the avatar of the passenger car, was elaborated in a VR class system EON Studio. The element integrating both of the mentioned software environments is a developed application that reads information from the virtual reality (VR) concerning the current position of the car avatar. Then, basing on the accepted algorithm, it sends control signals to respective joints of the model of the Stewart platform (CAD).

Integrated microfluidic platforms for investigating neuronal networks

NASA Astrophysics Data System (ADS)

Kim, Hyung Joon

This dissertation describes the development and application of integrated microfluidics-based assay platforms to study neuronal activities in the nervous system in-vitro. The assay platforms were fabricated using soft lithography and micro/nano fabrication including microfluidics, surface patterning, and nanomaterial synthesis. The use of integrated microfluidics-based assay platform allows culturing and manipulating many types of neuronal tissues in precisely controlled microenvironment. Furthermore, they provide organized multi-cellular in-vitro model, long-term monitoring with live cell imaging, and compatibility with molecular biology techniques and electrophysiology experiment. In this dissertation, the integrated microfluidics-based assay platforms are developed for investigation of neuronal activities such as local protein synthesis, impairment of axonal transport by chemical/physical variants, growth cone path finding under chemical/physical cues, and synaptic transmission in neuronal circuit. Chapter 1 describes the motivation, objectives, and scope for developing in-vitro platform to study various neuronal activities. Chapter 2 introduces microfluidic culture platform for biochemical assay with large-scale neuronal tissues that are utilized as model system in neuroscience research. Chapter 3 focuses on the investigation of impaired axonal transport by beta-Amyloid and oxidative stress. The platform allows to control neuronal processes and to quantify mitochondrial movement in various regions of axons away from applied drugs. Chapter 4 demonstrates the development of microfluidics-based growth cone turning assay to elucidate the mechanism underlying axon guidance under soluble factors and shear flow. Using this platform, the behaviors of growth cone of mammalian neurons are verified under the gradient of inhibitory molecules and also shear flow in well-controlled manner. In Chapter 5, I combine in-vitro multicellular model with microfabricated MEA

Lessons Learned: Transfer of the High-Definition Circulating Tumor Cell Assay Platform to Development as a Commercialized Clinical Assay Platform.

PubMed

Kuhn, P; Keating, S M; Baxter, G T; Thomas, K; Kolatkar, A; Sigman, C C

2017-11-01

Planning and transfer of a new technology platform developed in an academic setting to a start-up company for medical diagnostic product development may appear daunting and costly in terms of complexity, time, and resources. In this review we outline the key steps taken and lessons learned when a technology platform developed in an academic setting was transferred to a start-up company for medical diagnostic product development in the interest of elucidating development toolkits for academic groups and small start-up companies starting on the path to commercialization and regulatory approval. © 2017, The American Society for Clinical Pharmacology and Therapeutics.

Platform development for merging various information sources for water management: methodological, technical and operational aspects

NASA Astrophysics Data System (ADS)

Galvao, Diogo

2013-04-01

As a result of various economic, social and environmental factors, we can all experience the increase in importance of water resources at a global scale. As a consequence, we can also notice the increasing need of methods and systems capable of efficiently managing and combining the rich and heterogeneous data available that concerns, directly or indirectly, these water resources, such as in-situ monitoring station data, Earth Observation images and measurements, Meteorological modeling forecasts and Hydrological modeling. Under the scope of the MyWater project, we developed a water management system capable of satisfying just such needs, under a flexible platform capable of accommodating future challenges, not only in terms of sources of data but also on applicable models to extract information from it. From a methodological point of view, the MyWater platform obtains data from distinct sources, and in distinct formats, be they Satellite images or meteorological model forecasts, transforms and combines them in ways that allow them to be fed to a variety of hydrological models (such as MOHID Land, SIMGRO, etc…), which themselves can also be combined, using such approaches as those advocated by the OpenMI standard, to extract information in an automated and time efficient manner. Such an approach brings its own deal of challenges, and further research was developed under this project on the best ways to combine such data and on novel approaches to hydrological modeling (like the PriceXD model). From a technical point of view, the MyWater platform is structured according to a classical SOA architecture, with a flexible object oriented modular backend service responsible for all the model process management and data treatment, while the information extracted can be interacted with using a variety of frontends, from a web portal, including also a desktop client, down to mobile phone and tablet applications. From an operational point of view, a user can not only see

Development of a Platform for Simulating and Optimizing Thermoelectric Energy Systems

NASA Astrophysics Data System (ADS)

Kreuder, John J.

Thermoelectrics are solid state devices that can convert thermal energy directly into electrical energy. They have historically been used only in niche applications because of their relatively low efficiencies. With the advent of nanotechnology and improved manufacturing processes thermoelectric materials have become less costly and more efficient As next generation thermoelectric materials become available there is a need for industries to quickly and cost effectively seek out feasible applications for thermoelectric heat recovery platforms. Determining the technical and economic feasibility of such systems requires a model that predicts performance at the system level. Current models focus on specific system applications or neglect the rest of the system altogether, focusing on only module design and not an entire energy system. To assist in screening and optimizing entire energy systems using thermoelectrics, a novel software tool, Thermoelectric Power System Simulator (TEPSS), is developed for system level simulation and optimization of heat recovery systems. The platform is designed for use with a generic energy system so that most types of thermoelectric heat recovery applications can be modeled. TEPSS is based on object-oriented programming in MATLABRTM. A modular, shell based architecture is developed to carry out concept generation, system simulation and optimization. Systems are defined according to the components and interconnectivity specified by the user. An iterative solution process based on Newton's Method is employed to determine the system's steady state so that an objective function representing the cost of the system can be evaluated at the operating point. An optimization algorithm from MATLAB's Optimization Toolbox uses sequential quadratic programming to minimize this objective function with respect to a set of user specified design variables and constraints. During this iterative process many independent system simulations are executed and

Innovative Extension Models and Smallholders: How ICT platforms can Deliver Timely Information to Farmers in India.

NASA Astrophysics Data System (ADS)

Nagothu, U. S.

2016-12-01

Agricultural extension services, among others, contribute to improving rural livelihoods and enhancing economic development. Knowledge development and transfer from the cognitive science point of view, is about, how farmers use and apply their experiential knowledge as well as acquired new knowledge to solve new problems. This depends on the models adopted, the way knowledge is generated and delivered. New extension models based on ICT platforms and smart phones are promising. Results from a 5-year project (www.climaadapt.org) in India shows that farmer led-on farm validations of technologies and knowledge exchange through ICT based platforms outperformed state operated linear extension programs. Innovation here depends on the connectivity, net-working between stakeholders that are involved in generating, transferring and using the knowledge. Key words: Smallholders, Knowledge, Extension, Innovation, India

The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform

PubMed Central

Schachtschneider, Kyle M.; Schwind, Regina M.; Newson, Jordan; Kinachtchouk, Nickolas; Rizko, Mark; Mendoza-Elias, Nasya; Grippo, Paul; Principe, Daniel R.; Park, Alex; Overgaard, Nana H.; Jungersen, Gregers; Garcia, Kelly D.; Maker, Ajay V.; Rund, Laurie A.; Ozer, Howard; Gaba, Ron C.; Schook, Lawrence B.

2017-01-01

Despite an improved understanding of cancer molecular biology, immune landscapes, and advancements in cytotoxic, biologic, and immunologic anti-cancer therapeutics, cancer remains a leading cause of death worldwide. More than 8.2 million deaths were attributed to cancer in 2012, and it is anticipated that cancer incidence will continue to rise, with 19.3 million cases expected by 2025. The development and investigation of new diagnostic modalities and innovative therapeutic tools is critical for reducing the global cancer burden. Toward this end, transitional animal models serve a crucial role in bridging the gap between fundamental diagnostic and therapeutic discoveries and human clinical trials. Such animal models offer insights into all aspects of the basic science-clinical translational cancer research continuum (screening, detection, oncogenesis, tumor biology, immunogenicity, therapeutics, and outcomes). To date, however, cancer research progress has been markedly hampered by lack of a genotypically, anatomically, and physiologically relevant large animal model. Without progressive cancer models, discoveries are hindered and cures are improbable. Herein, we describe a transgenic porcine model—the Oncopig Cancer Model (OCM)—as a next-generation large animal platform for the study of hematologic and solid tumor oncology. With mutations in key tumor suppressor and oncogenes, TP53R167H and KRASG12D, the OCM recapitulates transcriptional hallmarks of human disease while also exhibiting clinically relevant histologic and genotypic tumor phenotypes. Moreover, as obesity rates increase across the global population, cancer patients commonly present clinically with multiple comorbid conditions. Due to the effects of these comorbidities on patient management, therapeutic strategies, and clinical outcomes, an ideal animal model should develop cancer on the background of representative comorbid conditions (tumor macro- and microenvironments). As observed in clinical

An integrated biotechnology platform for developing sustainable chemical processes.

PubMed

Barton, Nelson R; Burgard, Anthony P; Burk, Mark J; Crater, Jason S; Osterhout, Robin E; Pharkya, Priti; Steer, Brian A; Sun, Jun; Trawick, John D; Van Dien, Stephen J; Yang, Tae Hoon; Yim, Harry

2015-03-01

Genomatica has established an integrated computational/experimental metabolic engineering platform to design, create, and optimize novel high performance organisms and bioprocesses. Here we present our platform and its use to develop E. coli strains for production of the industrial chemical 1,4-butanediol (BDO) from sugars. A series of examples are given to demonstrate how a rational approach to strain engineering, including carefully designed diagnostic experiments, provided critical insights about pathway bottlenecks, byproducts, expression balancing, and commercial robustness, leading to a superior BDO production strain and process.

Development of a Modular Research Platform to Create Medical Observational Studies for Mobile Devices.

PubMed

Zens, Martin; Grotejohann, Birgit; Tassoni, Adrian; Duttenhoefer, Fabian; Südkamp, Norbert P; Niemeyer, Philipp

2017-05-23

Observational studies have proven to be a valuable resource in medical research, especially when performed on a large scale. Recently, mobile device-based observational studies have been discovered by an increasing number of researchers as a promising new source of information. However, the development and deployment of app-based studies is not trivial and requires profound programming skills. The aim of this project was to develop a modular online research platform that allows researchers to create medical studies for mobile devices without extensive programming skills. The platform approach for a modular research platform consists of three major components. A Web-based platform forms the researchers' main workplace. This platform communicates via a shared database with a platform independent mobile app. Furthermore, a separate Web-based login platform for physicians and other health care professionals is outlined and completes the concept. A prototype of the research platform has been developed and is currently in beta testing. Simple questionnaire studies can be created within minutes and published for testing purposes. Screenshots of an example study are provided, and the general working principle is displayed. In this project, we have created a basis for a novel research platform. The necessity and implications of a modular approach were displayed and an outline for future development given. International researchers are invited and encouraged to participate in this ongoing project. ©Martin Zens, Birgit Grotejohann, Adrian Tassoni, Fabian Duttenhoefer, Norbert P Südkamp, Philipp Niemeyer. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 23.05.2017.

{cross-disciplinary} Data CyberInfrastructure: A Different Approach to Developing Collaborative Earth and Environmental Science Research Platforms

NASA Astrophysics Data System (ADS)

Lenhardt, W. C.; Krishnamurthy, A.; Blanton, B.; Conway, M.; Coposky, J.; Castillo, C.; Idaszak, R.

2017-12-01

An integrated science cyberinfrastructure platform is fast becoming a norm in science, particularly where access to distributed resources, access to compute, data management tools, and collaboration tools are accessible to the end-user scientist without the need to spin up these services on their own. There platforms have various types of labels ranging from data commons to science-as-a-service. They tend to share common features, as outlined above. What tends to distinguish these platforms, however, is their affinity for particular domains, NanoHub - nanomaterials, iPlant - plant biology, Hydroshare - hydrology, and so on. The challenge still remains how to enable these platforms to be more easily adopted for use by other domains. This paper will provide an overview of RENCI's approach to creating a science platform that can be more easily adopted by new communities while also endeavoring to accelerate their research. At RENCI, we started with Hydroshare, but have now worked to generalize the methodology for application to other domains. This new effort is called xDCi, or {cross-disciplinary} Data CyberInfrastructure. We have adopted a broader approach to the challenge of domain adoption and includes two key elements in addition to the technology component. The first of these is how development is operationalized. RENCI implements a DevOps model of continuous development and deployment. This greatly increases the speed by which a new platform can come online and be refined to meet domain needs. DevOps also allows for migration over time, i.e. sustainability. The second element is a concierge model. In addition to the technical elements, and the more responsive development process, RENCI also supports domain adoption of the platform by providing a concierge service— dedicated expertise- in the following areas, Information Technology, Sustainable Software, Data Science, and Sustainability. The success of the RENCI methodology is illustrated by the adoption of the

Modeling and simulation of a Stewart platform type parallel structure robot

NASA Technical Reports Server (NTRS)

Lim, Gee Kwang; Freeman, Robert A.; Tesar, Delbert

1989-01-01

The kinematics and dynamics of a Stewart Platform type parallel structure robot (NASA's Dynamic Docking Test System) were modeled using the method of kinematic influence coefficients (KIC) and isomorphic transformations of system dependence from one set of generalized coordinates to another. By specifying the end-effector (platform) time trajectory, the required generalized input forces which would theoretically yield the desired motion were determined. It was found that the relationship between the platform motion and the actuators motion was nonlinear. In addition, the contribution to the total generalized forces, required at the actuators, from the acceleration related terms were found to be more significant than the velocity related terms. Hence, the curve representing the total required actuator force generally resembled the curve for the acceleration related force. Another observation revealed that the acceleration related effective inertia matrix I sub dd had the tendency to decouple, with the elements on the main diagonal of I sub dd being larger than the off-diagonal elements, while the velocity related inertia power array P sub ddd did not show such tendency. This tendency results in the acceleration related force curve of a given actuator resembling the acceleration profile of that particular actuator. Furthermore, it was indicated that the effective inertia matrix for the legs is more decoupled than that for the platform. These observations provide essential information for further research to develop an effective control strategy for real-time control of the Dynamic Docking Test System.

[Empowering the family-center health model: the toy library as a health promotion platform].

PubMed

Huang, Yu-Chu; Tsai, Yen-Chih

2011-02-01

Facing the lowest birth rates in its history, Taiwan is increasingly recognizing the centrality of children's healthcare needs to effective family care. The World Health Organization's goal of health for all emphasizes health promotion. However, little research attention has been given to how families actively promote personal health in everyday life. This article considers 'family-centric' healthcare, with a particular emphasis on children's health and well-being and the mother health promotion model. Authors employ a 'toy library' as the health promotion platform to build community interaction and empower the health enhancement process. Results suggested the following: 1. The fixed-point type toy library may be an effective tool in a health promotion strategy; 2. A model may be developed for rural institution agencies; 3. Cooperation may be facilitated using a medical service vehicle; 4. The love bag program can serve extended purposes. The authors found that the empowerment and growth of tribal mothers is a key element to facilitate the successful development of their children. Based on findings, the implementation of a toy library as the platform to build community-based health promotion model is suggested.

Building A Community Focused Data and Modeling Collaborative platform with Hardware Virtualization Technology

NASA Astrophysics Data System (ADS)

Michaelis, A.; Wang, W.; Melton, F. S.; Votava, P.; Milesi, C.; Hashimoto, H.; Nemani, R. R.; Hiatt, S. H.

2009-12-01

As the length and diversity of the global earth observation data records grow, modeling and analyses of biospheric conditions increasingly requires multiple terabytes of data from a diversity of models and sensors. With network bandwidth beginning to flatten, transmission of these data from centralized data archives presents an increasing challenge, and costs associated with local storage and management of data and compute resources are often significant for individual research and application development efforts. Sharing community valued intermediary data sets, results and codes from individual efforts with others that are not in direct funded collaboration can also be a challenge with respect to time, cost and expertise. We purpose a modeling, data and knowledge center that houses NASA satellite data, climate data and ancillary data where a focused community may come together to share modeling and analysis codes, scientific results, knowledge and expertise on a centralized platform, named Ecosystem Modeling Center (EMC). With the recent development of new technologies for secure hardware virtualization, an opportunity exists to create specific modeling, analysis and compute environments that are customizable, “archiveable” and transferable. Allowing users to instantiate such environments on large compute infrastructures that are directly connected to large data archives may significantly reduce costs and time associated with scientific efforts by alleviating users from redundantly retrieving and integrating data sets and building modeling analysis codes. The EMC platform also provides the possibility for users receiving indirect assistance from expertise through prefabricated compute environments, potentially reducing study “ramp up” times.

Development of cloud-operating platform for detention facility design

NASA Astrophysics Data System (ADS)

Tun Lee, Kwan; Hung, Meng-Chiu; Tseng, Wei-Fan; Chan, Yi-Ping

2017-04-01

In the past 20 years, the population of Taiwan has accumulated in urban areas. The land development has changed the hydrological environment and resulted in the increase of surface runoff and shortened the time to peak discharge. The change of runoff characteristics increases the flood risk and reduces resilient ability of the city during flood. Considering that engineering measures may not be easy to implement in populated cities, detention facilities set on building basements have been proposed to compromise the increase of surface runoff resulting from development activities. In this study, a web-based operational platform has been developed to integrate the GIS technologies, hydrological analyses, as well as relevant regulations for the design of detention facilities. The design procedure embedded in the system includes a prior selection of type and size of the detention facility, integrated hydrological analysis for the developing site, and inspection of relevant regulations. After login the platform, designers can access the system database to retrieve road maps, land use coverages, and storm sewer information. Once the type, size, inlet, and outlet of the detention facility are assigned, the system can acquire the rainfall intensity-duration-frequency information from adjacent rain gauges to perform hydrological analyses for the developing site. The increase of the runoff volume due to the development and the reduction of the outflow peak through the construction of the detention facility can be estimated. The outflow peak at the target site is then checked with relevant regulations to confirm the suitability of the detention facility design. The proposed web-based platform can provide a concise layout of the detention facility and the drainageway of the developing site on a graphical interface. The design information can also be delivered directly through a web link to authorities for inspecting to simplify the complex administrative procedures.

Immunocontraception: Filamentous Bacteriophage as a Platform for Vaccine Development.

PubMed

Samoylova, Tatiana I; Braden, Timothy D; Spencer, Jennifer A; Bartol, Frank F

2017-11-20

Population control of domestic, wild, invasive, and captive animal species is a global issue of importance to public health, animal welfare and the economy. There is pressing need for effective, safe, and inexpensive contraceptive technologies to address this problem. Contraceptive vaccines, designed to stimulate the immune system in order to block critical reproductive events and suppress fertility, may provide a solution. Filamentous bacteriophages can be used as platforms for development of such vaccines. In this review authors highlight structural and immunogenic properties of filamentous phages, and discuss applications of phage-peptide vaccines for advancement of immunocontraception technology in animals. Phages can be engineered to display fusion (non-phage) peptides as coat proteins. Such modifications can be accomplished via genetic manipulation of phage DNA, or by chemical conjugation of synthetic peptides to phage surface proteins. Phage fusions with antigenic determinants induce humoral as well as cell-mediated immune responses in animals, making them attractive as vaccines. Additional advantages of the phage platform include environmental stability, low cost, and safety for immunized animals and those administering the vaccines. Filamentous phages are viable platforms for vaccine development that can be engineered with molecular and organismal specificity. Phage-based vaccines can be produced in abundance at low cost, are environmentally stable, and are immunogenic when administered via multiple routes. These features are essential for a contraceptive vaccine to be operationally practical in animal applications. Adaptability of the phage platform also makes it attractive for design of human immunocontraceptive agents. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Immunocontraception: Filamentous Bacteriophage as a Platform for Vaccine Development

PubMed Central

Samoylova, Tatiana I.; Braden, Timothy D.; Spencer, Jennifer A.; Bartol, Frank F.

2017-01-01

Background: Population control of domestic, wild, invasive, and captive animal species is a global issue of importance to public health, animal welfare and the economy. There is pressing need for effective, safe, and inexpensive contraceptive technologies to ad-dress this problem. Contraceptive vaccines, designed to stimulate the immune system in order to block critical reproductive events and suppress fertility, may provide a solution. Fil-amentous bacteriophages can be used as platforms for development of such vaccines. Objective: In this review authors highlight structural and immunogenic properties of fila-mentous phages, and discuss applications of phage-peptide vaccines for advancement of immunocontraception technology in animals. Results: Phages can be engineered to display fusion (non-phage) peptides as coat proteins. Such modifications can be accomplished via genetic manipulation of phage DNA, or by chemical conjugation of synthetic peptides to phage surface proteins. Phage fusions with antigenic determinants induce humoral as well as cell-mediated immune responses in ani-mals, making them attractive as vaccines. Additional advantages of the phage platform include environmental stability, low cost, and safety for immunized animals and those ad-ministering the vaccines. Conclusion: Filamentous phages are viable platforms for vaccine development that can be engineered with molecular and organismal specificity. Phage-based vaccines can be pro-duced in abundance at low cost, are environmentally stable, and are immunogenic when administered via multiple routes. These features are essential for a contraceptive vaccine to be operationally practical in animal applications. Adaptability of the phage platform also makes it attractive for design of human immunocontraceptive agents. PMID:28901276

A web platform for integrated surface water - groundwater modeling and data management

NASA Astrophysics Data System (ADS)

Fatkhutdinov, Aybulat; Stefan, Catalin; Junghanns, Ralf

2016-04-01

Model-based decision support systems are considered to be reliable and time-efficient tools for resources management in various hydrology related fields. However, searching and acquisition of the required data, preparation of the data sets for simulations as well as post-processing, visualization and publishing of the simulations results often requires significantly more work and time than performing the modeling itself. The purpose of the developed software is to combine data storage facilities, data processing instruments and modeling tools in a single platform which potentially can reduce time required for performing simulations, hence decision making. The system is developed within the INOWAS (Innovative Web Based Decision Support System for Water Sustainability under a Changing Climate) project. The platform integrates spatially distributed catchment scale rainfall - runoff, infiltration and groundwater flow models with data storage, processing and visualization tools. The concept is implemented in a form of a web-GIS application and is build based on free and open source components, including the PostgreSQL database management system, Python programming language for modeling purposes, Mapserver for visualization and publishing the data, Openlayers for building the user interface and others. Configuration of the system allows performing data input, storage, pre- and post-processing and visualization in a single not disturbed workflow. In addition, realization of the decision support system in the form of a web service provides an opportunity to easily retrieve and share data sets as well as results of simulations over the internet, which gives significant advantages for collaborative work on the projects and is able to significantly increase usability of the decision support system.

Gryphon: A Hybrid Agent-Based Modeling and Simulation Platform for Infectious Diseases

NASA Astrophysics Data System (ADS)

Yu, Bin; Wang, Jijun; McGowan, Michael; Vaidyanathan, Ganesh; Younger, Kristofer

In this paper we present Gryphon, a hybrid agent-based stochastic modeling and simulation platform developed for characterizing the geographic spread of infectious diseases and the effects of interventions. We study both local and non-local transmission dynamics of stochastic simulations based on the published parameters and data for SARS. The results suggest that the expected numbers of infections and the timeline of control strategies predicted by our stochastic model are in reasonably good agreement with previous studies. These preliminary results indicate that Gryphon is able to characterize other future infectious diseases and identify endangered regions in advance.

Geosynchronous platform definition study. Volume 5: Geosynchronous platform synthesis

NASA Technical Reports Server (NTRS)

1973-01-01

The development is described of the platform configurations, support subsystems, mission equipment, and servicing concepts. A common support module is developed; subsystem concepts are traded off; data relay, TDRS, earth observational, astro-physics, and advanced navigation and traffic control mission equipment concepts are postulated; and ancillary equipment required for delivery and on-orbit servicing interfaces with geosynchronous platforms is grossly defined. The general approach was to develop a platform concept capable of evolving through three on-orbit servicing modes: remote, EVA, and shirtsleeve. The definition of the equipment is to the assembly level. Weight, power, and volumetric data are compiled for all the platforms.

Development of a novel automated cell isolation, expansion, and characterization platform.

PubMed

Franscini, Nicola; Wuertz, Karin; Patocchi-Tenzer, Isabel; Durner, Roland; Boos, Norbert; Graf-Hausner, Ursula

2011-06-01

Implementation of regenerative medicine in the clinical setting requires not only biological inventions, but also the development of reproducible and safe method for cell isolation and expansion. As the currently used manual techniques do not fulfill these requirements, there is a clear need to develop an adequate robotic platform for automated, large-scale production of cells or cell-based products. Here, we demonstrate an automated liquid-handling cell-culture platform that can be used to isolate, expand, and characterize human primary cells (e.g., from intervertebral disc tissue) with results that are comparable to the manual procedure. Specifically, no differences could be observed for cell yield, viability, aggregation rate, growth rate, and phenotype. Importantly, all steps-from the enzymatic isolation of cells through the biopsy to the final quality control-can be performed completely by the automated system because of novel tools that were incorporated into the platform. This automated cell-culture platform can therefore replace entirely manual processes in areas that require high throughput while maintaining stability and safety, such as clinical or industrial settings. Copyright © 2011 Society for Laboratory Automation and Screening. Published by Elsevier Inc. All rights reserved.

Simple diazonium chemistry to develop specific gene sensing platforms.

PubMed

Revenga-Parra, M; García-Mendiola, T; González-Costas, J; González-Romero, E; Marín, A García; Pau, J L; Pariente, F; Lorenzo, E

2014-02-27

A simple strategy for covalent immobilizing DNA sequences, based on the formation of stable diazonized conducting platforms, is described. The electrochemical reduction of 4-nitrobenzenediazonium salt onto screen-printed carbon electrodes (SPCE) in aqueous media gives rise to terminal grafted amino groups. The presence of primary aromatic amines allows the formation of diazonium cations capable to react with the amines present at the DNA capture probe. As a comparison a second strategy based on the binding of aminated DNA capture probes to the developed diazonized conducting platforms through a crosslinking agent was also employed. The resulting DNA sensing platforms were characterized by cyclic voltammetry, electrochemical impedance spectroscopy and spectroscopic ellipsometry. The hybridization event with the complementary sequence was detected using hexaamineruthenium (III) chloride as electrochemical indicator. Finally, they were applied to the analysis of a 145-bp sequence from the human gene MRP3, reaching a detection limit of 210 pg μL(-1). Copyright © 2014 Elsevier B.V. All rights reserved.

Developing cloud applications using the e-Science Central platform.

PubMed

Hiden, Hugo; Woodman, Simon; Watson, Paul; Cala, Jacek

2013-01-28

This paper describes the e-Science Central (e-SC) cloud data processing system and its application to a number of e-Science projects. e-SC provides both software as a service (SaaS) and platform as a service for scientific data management, analysis and collaboration. It is a portable system and can be deployed on both private (e.g. Eucalyptus) and public clouds (Amazon AWS and Microsoft Windows Azure). The SaaS application allows scientists to upload data, edit and run workflows and share results in the cloud, using only a Web browser. It is underpinned by a scalable cloud platform consisting of a set of components designed to support the needs of scientists. The platform is exposed to developers so that they can easily upload their own analysis services into the system and make these available to other users. A representational state transfer-based application programming interface (API) is also provided so that external applications can leverage the platform's functionality, making it easier to build scalable, secure cloud-based applications. This paper describes the design of e-SC, its API and its use in three different case studies: spectral data visualization, medical data capture and analysis, and chemical property prediction.

Developing cloud applications using the e-Science Central platform

PubMed Central

Hiden, Hugo; Woodman, Simon; Watson, Paul; Cala, Jacek

2013-01-01

This paper describes the e-Science Central (e-SC) cloud data processing system and its application to a number of e-Science projects. e-SC provides both software as a service (SaaS) and platform as a service for scientific data management, analysis and collaboration. It is a portable system and can be deployed on both private (e.g. Eucalyptus) and public clouds (Amazon AWS and Microsoft Windows Azure). The SaaS application allows scientists to upload data, edit and run workflows and share results in the cloud, using only a Web browser. It is underpinned by a scalable cloud platform consisting of a set of components designed to support the needs of scientists. The platform is exposed to developers so that they can easily upload their own analysis services into the system and make these available to other users. A representational state transfer-based application programming interface (API) is also provided so that external applications can leverage the platform's functionality, making it easier to build scalable, secure cloud-based applications. This paper describes the design of e-SC, its API and its use in three different case studies: spectral data visualization, medical data capture and analysis, and chemical property prediction. PMID:23230161

An Online Prediction Platform to Support the Environmental ...

EPA Pesticide Factsheets

Historical QSAR models are currently utilized across a broad range of applications within the U.S. Environmental Protection Agency (EPA). These models predict basic physicochemical properties (e.g., logP, aqueous solubility, vapor pressure), which are then incorporated into exposure, fate and transport models. Whereas the classical manner of publishing results in peer-reviewed journals remains appropriate, there are substantial benefits to be gained by providing enhanced, open access to the training data sets and resulting models. Benefits include improved transparency, more flexibility to expand training sets and improve model algorithms, and greater ability to independently characterize model performance both globally and in local areas of chemistry. We have developed a web-based prediction platform that uses open-source descriptors and modeling algorithms, employs modern cheminformatics technologies, and is tailored for ease of use by the toxicology and environmental regulatory community. This tool also provides web-services to meet both EPA’s projects and the modeling community at-large. The platform hosts models developed within EPA’s National Center for Computational Toxicology, as well as those developed by other EPA scientists and the outside scientific community. Recognizing that there are other on-line QSAR model platforms currently available which have additional capabilities, we connect to such services, where possible, to produce an integrated

The CAnadian Surface Prediction ARchive (CaSPAr): A Platform to Enhance Environmental Modelling in Canada and Globally

NASA Astrophysics Data System (ADS)

Tolson, B.; Mai, J.; Kornelsen, K. C.; Coulibaly, P. D.; Anctil, F.; Fortin, V.; Leahy, M.; Hall, B.

2017-12-01

Environmental models are tools for the modern society for a wide range of applications such as flood and drought monitoring, carbon storage and release estimates, predictions of power generation amounts, or reservoir management amongst others. Environmental models differ in the types of processes they incorporate, where land surface models focus on the energy, water, and carbon cycle of the land and hydrological models concentrate mainly on the water cycle. All these models, however, have in common that they rely on environmental input data from ground observations such as temperature, precipitation and/or radiation to force the model. If the same model is run in forecast mode, numerical weather predictions (NWPs) are needed to replace these ground observations. Therefore, it is critical that NWP data be available to develop models and validate forecast performance. These data are provided by the Meteorological Service of Canada (MSC) on a daily basis. MSC provides multiple products ranging from large scale global models ( 33km/grid cell) to high resolution pan-Canadian models ( 2.5km/grid cell). Operational products providing forecasts in real-time are made publicly available only at the time of issue through various means with new forecasts issued 2-4 times per day. Unfortunately, long term storage of these data are offline and relatively inaccessible to the research and operational communities. The new Canadian Surface Prediction Archive (CaSPAr) platform is an accessible rolling archive of 10 of MSC's NWP products. The 500TB platform will allow users to extract specific time periods, regions of interest and variables of interest in an easy to access NetCDF format. CaSPAr and community contributed post-processing scripts and tools are being developed such that the users, for example, can interpolate the data due to their needs or auto-generate model forcing files. We will present the CaSPAr platform and provide some insights in the current development of the web

Development of Photoacoustic Sensing Platforms at the US Army Research Laboratory

DTIC Science & Technology

2016-09-01

RDX and TNT explosives with carbon dioxide laser. J Appl Spectrosc. 2006;73(1):123–129. 45. Petzold A, Niessner R. Photoacoustic soot sensor for in...Development of Photoacoustic Sensing Platforms at the US Army Research Laboratory by Ellen L Holthoff and Paul M Pellegrino Sensors and Electron Devices...NOTES 14. ABSTRACT Traditionally, chemical sensing platforms have been hampered by the opposing concerns of increasing sensor capability while

Services Oriented Smart City Platform Based On 3d City Model Visualization

NASA Astrophysics Data System (ADS)

Prandi, F.; Soave, M.; Devigili, F.; Andreolli, M.; De Amicis, R.

2014-04-01

The rapid technological evolution, which is characterizing all the disciplines involved within the wide concept of smart cities, is becoming a key factor to trigger true user-driven innovation. However to fully develop the Smart City concept to a wide geographical target, it is required an infrastructure that allows the integration of heterogeneous geographical information and sensor networks into a common technological ground. In this context 3D city models will play an increasingly important role in our daily lives and become an essential part of the modern city information infrastructure (Spatial Data Infrastructure). The work presented in this paper describes an innovative Services Oriented Architecture software platform aimed at providing smartcities services on top of 3D urban models. 3D city models are the basis of many applications and can became the platform for integrating city information within the Smart-Cites context. In particular the paper will investigate how the efficient visualisation of 3D city models using different levels of detail (LODs) is one of the pivotal technological challenge to support Smart-Cities applications. The goal is to provide to the final user realistic and abstract 3D representations of the urban environment and the possibility to interact with a massive amounts of semantic information contained into the geospatial 3D city model. The proposed solution, using OCG standards and a custom service to provide 3D city models, lets the users to consume the services and interact with the 3D model via Web in a more effective way.

Developing a Web Platform to Support a Community of Practice: A Mixed Methods Study in Pediatric Physiotherapy.

PubMed

Pratte, Gabrielle; Hurtubise, Karen; Rivard, Lisa; Berbari, Jade; Camden, Chantal

2018-01-01

Web platforms are increasingly used to support virtual interactions between members of communities of practice (CoP). However, little is known about how to develop these platforms to support the implementation of best practices for health care professionals. The aim of this article is to explore pediatric physiotherapists' (PTs) perspectives regarding the utility and usability of the characteristic of a web platform developed to support virtual communities of practice (vCoP). This study adopted an explanatory sequential mixed methods design. A web platform supporting the interactions of vCoP members was developed for PTs working with children with developmental coordination disorder. Specific strategies and features were created to support the effectiveness of the platform across three domains: social, information-quality, and system-quality factors. Quantitative data were collected from a cross-sectional survey (n = 41) after 5 months of access to the web platform. Descriptive statistics were calculated. Qualitative data were also collected from semistructured interviews (n = 9), which were coded, interpreted, and analyzed by using Boucher's Web Ergonomics Conceptual Framework. The utility of web platform characteristics targeting the three key domain factors were generally perceived positively by PTs. However, web platform usability issues were noted by PTs, including problems with navigation and information retrieval. Web platform aiming to support vCoP should be carefully developed to target potential users' needs. Whenever possible, users should co-construct the web platform with vCoP developers. Moreover, each of the developed characteristics (eg, newsletter, search function) should be evaluated in terms of utility and usability for the users.

A case study in open source innovation: developing the Tidepool Platform for interoperability in type 1 diabetes management.

PubMed

Neinstein, Aaron; Wong, Jenise; Look, Howard; Arbiter, Brandon; Quirk, Kent; McCanne, Steve; Sun, Yao; Blum, Michael; Adi, Saleh

2016-03-01

Develop a device-agnostic cloud platform to host diabetes device data and catalyze an ecosystem of software innovation for type 1 diabetes (T1D) management. An interdisciplinary team decided to establish a nonprofit company, Tidepool, and build open-source software. Through a user-centered design process, the authors created a software platform, the Tidepool Platform, to upload and host T1D device data in an integrated, device-agnostic fashion, as well as an application ("app"), Blip, to visualize the data. Tidepool's software utilizes the principles of modular components, modern web design including REST APIs and JavaScript, cloud computing, agile development methodology, and robust privacy and security. By consolidating the currently scattered and siloed T1D device data ecosystem into one open platform, Tidepool can improve access to the data and enable new possibilities and efficiencies in T1D clinical care and research. The Tidepool Platform decouples diabetes apps from diabetes devices, allowing software developers to build innovative apps without requiring them to design a unique back-end (e.g., database and security) or unique ways of ingesting device data. It allows people with T1D to choose to use any preferred app regardless of which device(s) they use. The authors believe that the Tidepool Platform can solve two current problems in the T1D device landscape: 1) limited access to T1D device data and 2) poor interoperability of data from different devices. If proven effective, Tidepool's open source, cloud model for health data interoperability is applicable to other healthcare use cases. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association.

A case study in open source innovation: developing the Tidepool Platform for interoperability in type 1 diabetes management

PubMed Central

Wong, Jenise; Look, Howard; Arbiter, Brandon; Quirk, Kent; McCanne, Steve; Sun, Yao; Blum, Michael; Adi, Saleh

2016-01-01

Objective Develop a device-agnostic cloud platform to host diabetes device data and catalyze an ecosystem of software innovation for type 1 diabetes (T1D) management. Materials and Methods An interdisciplinary team decided to establish a nonprofit company, Tidepool, and build open-source software. Results Through a user-centered design process, the authors created a software platform, the Tidepool Platform, to upload and host T1D device data in an integrated, device-agnostic fashion, as well as an application (“app”), Blip, to visualize the data. Tidepool’s software utilizes the principles of modular components, modern web design including REST APIs and JavaScript, cloud computing, agile development methodology, and robust privacy and security. Discussion By consolidating the currently scattered and siloed T1D device data ecosystem into one open platform, Tidepool can improve access to the data and enable new possibilities and efficiencies in T1D clinical care and research. The Tidepool Platform decouples diabetes apps from diabetes devices, allowing software developers to build innovative apps without requiring them to design a unique back-end (e.g., database and security) or unique ways of ingesting device data. It allows people with T1D to choose to use any preferred app regardless of which device(s) they use. Conclusion The authors believe that the Tidepool Platform can solve two current problems in the T1D device landscape: 1) limited access to T1D device data and 2) poor interoperability of data from different devices. If proven effective, Tidepool’s open source, cloud model for health data interoperability is applicable to other healthcare use cases. PMID:26338218

Chromatography process development in the quality by design paradigm I: Establishing a high-throughput process development platform as a tool for estimating "characterization space" for an ion exchange chromatography step.

PubMed

Bhambure, R; Rathore, A S

2013-01-01

This article describes the development of a high-throughput process development (HTPD) platform for developing chromatography steps. An assessment of the platform as a tool for establishing the "characterization space" for an ion exchange chromatography step has been performed by using design of experiments. Case studies involving use of a biotech therapeutic, granulocyte colony-stimulating factor have been used to demonstrate the performance of the platform. We discuss the various challenges that arise when working at such small volumes along with the solutions that we propose to alleviate these challenges to make the HTPD data suitable for empirical modeling. Further, we have also validated the scalability of this platform by comparing the results from the HTPD platform (2 and 6 μL resin volumes) against those obtained at the traditional laboratory scale (resin volume, 0.5 mL). We find that after integration of the proposed correction factors, the HTPD platform is capable of performing the process optimization studies at 170-fold higher productivity. The platform is capable of providing semi-quantitative assessment of the effects of the various input parameters under consideration. We think that platform such as the one presented is an excellent tool for examining the "characterization space" and reducing the extensive experimentation at the traditional lab scale that is otherwise required for establishing the "design space." Thus, this platform will specifically aid in successful implementation of quality by design in biotech process development. This is especially significant in view of the constraints with respect to time and resources that the biopharma industry faces today. Copyright © 2013 American Institute of Chemical Engineers.

Development of a cloud-based Bioinformatics Training Platform.

PubMed

Revote, Jerico; Watson-Haigh, Nathan S; Quenette, Steve; Bethwaite, Blair; McGrath, Annette; Shang, Catherine A

2017-05-01

The Bioinformatics Training Platform (BTP) has been developed to provide access to the computational infrastructure required to deliver sophisticated hands-on bioinformatics training courses. The BTP is a cloud-based solution that is in active use for delivering next-generation sequencing training to Australian researchers at geographically dispersed locations. The BTP was built to provide an easy, accessible, consistent and cost-effective approach to delivering workshops at host universities and organizations with a high demand for bioinformatics training but lacking the dedicated bioinformatics training suites required. To support broad uptake of the BTP, the platform has been made compatible with multiple cloud infrastructures. The BTP is an open-source and open-access resource. To date, 20 training workshops have been delivered to over 700 trainees at over 10 venues across Australia using the BTP. © The Author 2016. Published by Oxford University Press.

Development of a cloud-based Bioinformatics Training Platform

PubMed Central

Revote, Jerico; Watson-Haigh, Nathan S.; Quenette, Steve; Bethwaite, Blair; McGrath, Annette

2017-01-01

Abstract The Bioinformatics Training Platform (BTP) has been developed to provide access to the computational infrastructure required to deliver sophisticated hands-on bioinformatics training courses. The BTP is a cloud-based solution that is in active use for delivering next-generation sequencing training to Australian researchers at geographically dispersed locations. The BTP was built to provide an easy, accessible, consistent and cost-effective approach to delivering workshops at host universities and organizations with a high demand for bioinformatics training but lacking the dedicated bioinformatics training suites required. To support broad uptake of the BTP, the platform has been made compatible with multiple cloud infrastructures. The BTP is an open-source and open-access resource. To date, 20 training workshops have been delivered to over 700 trainees at over 10 venues across Australia using the BTP. PMID:27084333

Snaps, Selfies, and Shares: How Three Popular Social Media Platforms Contribute to the Sociocultural Model of Disordered Eating Among Young Women.

PubMed

Saunders, Jessica F; Eaton, Asia A

2018-06-01

The current study aimed to integrate and test the sociocultural model of disordered eating with theories explaining the impact of mass media on the development of disordered eating for users of three popular social networking platforms. Young women social networking site (SNS) users (age 18-24) who had never received an eating disorder diagnosis (N = 637) completed questions capturing their SNS gratifications and usage, body surveillance, social comparisons, body dissatisfaction, and eating pathology. Measures were administered in one online session. Model relationships were similar across users of all three SNS platforms: Facebook, Instagram, and Snapchat. Users of all platforms demonstrated a significant positive relationship between upward comparisons and disordered eating outcomes, and between body surveillance and disordered eating outcomes, although differences between models did emerge. Empirical findings support extending the sociocultural model of disordered eating to include SNS uses and gratifications.

[Construction of platform on the three-dimensional finite element model of the dentulous mandibular body of a normal person].

PubMed

Gong, Lu-Lu; Zhu, Jing; Ding, Zu-Quan; Li, Guo-Qiang; Wang, Li-Ming; Yan, Bo-Yong

2008-04-01

To develop a method to construct a three-dimensional finite element model of the dentulous mandibular body of a normal person. A series of pictures with the interval of 0.1 mm were taken by CT scanning. After extracting the coordinates of key points of some pictures by the procedure, we used a C program to process the useful data, and constructed a platform of the three-dimensional finite element model of the dentulous mandibular body with the Ansys software for finite element analysis. The experimental results showed that the platform of the three-dimensional finite element model of the dentulous mandibular body was more accurate and applicable. The exact three-dimensional shape of model was well constructed, and each part of this model, such as one single tooth, can be deleted, which can be used to emulate various tooth-loss clinical cases. The three-dimensional finite element model is constructed with life-like shapes of dental cusps. Each part of this model can be easily removed. In conclusion, this experiment provides a good platform of biomechanical analysis on various tooth-loss clinical cases.

Development and Characteristics of a Mobile, Semi-Autonomous Floating Platform for in situ Lake Measurements

NASA Astrophysics Data System (ADS)

Barry, D.; Lemmin, U.; Le Dantec, N.; Zulliger, L.; Rusterholz, M.; Bolay, M.; Rossier, J.; Kangur, K.

2013-12-01

In the development of sustainable management strategies of lakes more insight into their physical, chemical and ecological dynamics is needed. Field data obtained from various types of sensors with adequate spatial and temporal sampling rate are essential to understand better the processes that govern fluxes and pathways of water masses and transported compounds, whether for model validation or for monitoring purposes. One advantage of unmanned platforms is that they limit the disturbances typically affecting the quality of data collected on small vessels, including perturbations caused by movements of onboard crew. We have developed a mobile, semi-autonomous floating platform with 8 h power autonomy using a 5 m long by 2.5 m wide catamaran. Our approach focused on modularity and high payload capacity in order to accommodate a large number of sensors both in terms of electronic (power and data) and mechanical constraints of integration. Software architecture and onboard electronics use National Instruments technology to simplify and standardize integration of sensors, actuators and communication. Piecewise-movable deck sections allow optimizing platform stability depending on the payload. The entire system is controlled by a remote computer located on an accompanying vessel and connected via a wireless link with a range of over 1 km. Real-time transmission of GPS-stamped measurements allows immediate modifications in the survey plan if needed. The displacement of the platform is semi-autonomous, with the options of either autopilot mode following a pre-planned course specified by waypoints or remote manual control from the accompanying vessel. Maintenance of permanent control over the platform displacement is required for safety reasons with respect to other users of the lake. Currently, the sensor payload comprises an array of fast temperature probes, a bottom-tracking ADCP and atmospheric sensors including a radiometer. A towed CTD with additional water quality

Crops In Silico: Generating Virtual Crops Using an Integrative and Multi-scale Modeling Platform.

PubMed

Marshall-Colon, Amy; Long, Stephen P; Allen, Douglas K; Allen, Gabrielle; Beard, Daniel A; Benes, Bedrich; von Caemmerer, Susanne; Christensen, A J; Cox, Donna J; Hart, John C; Hirst, Peter M; Kannan, Kavya; Katz, Daniel S; Lynch, Jonathan P; Millar, Andrew J; Panneerselvam, Balaji; Price, Nathan D; Prusinkiewicz, Przemyslaw; Raila, David; Shekar, Rachel G; Shrivastava, Stuti; Shukla, Diwakar; Srinivasan, Venkatraman; Stitt, Mark; Turk, Matthew J; Voit, Eberhard O; Wang, Yu; Yin, Xinyou; Zhu, Xin-Guang

2017-01-01

Multi-scale models can facilitate whole plant simulations by linking gene networks, protein synthesis, metabolic pathways, physiology, and growth. Whole plant models can be further integrated with ecosystem, weather, and climate models to predict how various interactions respond to environmental perturbations. These models have the potential to fill in missing mechanistic details and generate new hypotheses to prioritize directed engineering efforts. Outcomes will potentially accelerate improvement of crop yield, sustainability, and increase future food security. It is time for a paradigm shift in plant modeling, from largely isolated efforts to a connected community that takes advantage of advances in high performance computing and mechanistic understanding of plant processes. Tools for guiding future crop breeding and engineering, understanding the implications of discoveries at the molecular level for whole plant behavior, and improved prediction of plant and ecosystem responses to the environment are urgently needed. The purpose of this perspective is to introduce Crops in silico (cropsinsilico.org), an integrative and multi-scale modeling platform, as one solution that combines isolated modeling efforts toward the generation of virtual crops, which is open and accessible to the entire plant biology community. The major challenges involved both in the development and deployment of a shared, multi-scale modeling platform, which are summarized in this prospectus, were recently identified during the first Crops in silico Symposium and Workshop.

Crops In Silico: Generating Virtual Crops Using an Integrative and Multi-scale Modeling Platform

PubMed Central

Marshall-Colon, Amy; Long, Stephen P.; Allen, Douglas K.; Allen, Gabrielle; Beard, Daniel A.; Benes, Bedrich; von Caemmerer, Susanne; Christensen, A. J.; Cox, Donna J.; Hart, John C.; Hirst, Peter M.; Kannan, Kavya; Katz, Daniel S.; Lynch, Jonathan P.; Millar, Andrew J.; Panneerselvam, Balaji; Price, Nathan D.; Prusinkiewicz, Przemyslaw; Raila, David; Shekar, Rachel G.; Shrivastava, Stuti; Shukla, Diwakar; Srinivasan, Venkatraman; Stitt, Mark; Turk, Matthew J.; Voit, Eberhard O.; Wang, Yu; Yin, Xinyou; Zhu, Xin-Guang

2017-01-01

Multi-scale models can facilitate whole plant simulations by linking gene networks, protein synthesis, metabolic pathways, physiology, and growth. Whole plant models can be further integrated with ecosystem, weather, and climate models to predict how various interactions respond to environmental perturbations. These models have the potential to fill in missing mechanistic details and generate new hypotheses to prioritize directed engineering efforts. Outcomes will potentially accelerate improvement of crop yield, sustainability, and increase future food security. It is time for a paradigm shift in plant modeling, from largely isolated efforts to a connected community that takes advantage of advances in high performance computing and mechanistic understanding of plant processes. Tools for guiding future crop breeding and engineering, understanding the implications of discoveries at the molecular level for whole plant behavior, and improved prediction of plant and ecosystem responses to the environment are urgently needed. The purpose of this perspective is to introduce Crops in silico (cropsinsilico.org), an integrative and multi-scale modeling platform, as one solution that combines isolated modeling efforts toward the generation of virtual crops, which is open and accessible to the entire plant biology community. The major challenges involved both in the development and deployment of a shared, multi-scale modeling platform, which are summarized in this prospectus, were recently identified during the first Crops in silico Symposium and Workshop. PMID:28555150

Framework Programmable Platform for the Advanced Software Development Workstation (FPP/ASDW). Demonstration framework document. Volume 1: Concepts and activity descriptions

NASA Technical Reports Server (NTRS)

Mayer, Richard J.; Blinn, Thomas M.; Dewitte, Paul S.; Crump, John W.; Ackley, Keith A.

1992-01-01

The Framework Programmable Software Development Platform (FPP) is a project aimed at effectively combining tool and data integration mechanisms with a model of the software development process to provide an intelligent integrated software development environment. Guided by the model, this system development framework will take advantage of an integrated operating environment to automate effectively the management of the software development process so that costly mistakes during the development phase can be eliminated. The Advanced Software Development Workstation (ASDW) program is conducting research into development of advanced technologies for Computer Aided Software Engineering (CASE).

Development of a gastroretentive pulsatile drug delivery platform.

PubMed

Thitinan, Sumalee; McConville, Jason T

2012-04-01

To develop a novel gastroretentive pulsatile drug delivery platform by combining the advantages of floating dosage forms for the stomach and pulsatile drug delivery systems. A gastric fluid impermeable capsule body was used as a vessel to contain one or more drug layer(s) as well as one or more lag-time controlling layer(s). A controlled amount of air was sealed in the innermost portion of the capsule body to reduce the overall density of the drug delivery platform, enabling gastric floatation. An optimal mass fill inside the gastric fluid impermeable capsule body enabled buoyancy in a vertical orientation to provide a constant surface area for controlled erosion of the lag-time controlling layer. The lag-time controlling layer consisted of a swellable polymer, which rapidly formed a gel to seal the mouth of capsule body and act as a barrier to gastric fluid ingress. By varying the composition of the lag-time controlling layer, it was possible to selectively program the onset of the pulsatile delivery of a drug. This new delivery platform offers a new method of delivery for a variety of suitable drugs targeted in chronopharmaceutical therapy. This strategy could ultimately improve drug efficacy and patient compliance, and reduce harmful side effects by scaling back doses of drug administered. © 2012 The Authors. JPP © 2012 Royal Pharmaceutical Society.

A GPU-accelerated Monte Carlo dose calculation platform and its application toward validating an MRI-guided radiation therapy beam model

PubMed Central

Wang, Yuhe; Mazur, Thomas R.; Green, Olga; Hu, Yanle; Li, Hua; Rodriguez, Vivian; Wooten, H. Omar; Yang, Deshan; Zhao, Tianyu; Mutic, Sasa; Li, H. Harold

2016-01-01

Purpose: The clinical commissioning of IMRT subject to a magnetic field is challenging. The purpose of this work is to develop a GPU-accelerated Monte Carlo dose calculation platform based on penelope and then use the platform to validate a vendor-provided MRIdian head model toward quality assurance of clinical IMRT treatment plans subject to a 0.35 T magnetic field. Methods: penelope was first translated from fortran to c++ and the result was confirmed to produce equivalent results to the original code. The c++ code was then adapted to cuda in a workflow optimized for GPU architecture. The original code was expanded to include voxelized transport with Woodcock tracking, faster electron/positron propagation in a magnetic field, and several features that make gpenelope highly user-friendly. Moreover, the vendor-provided MRIdian head model was incorporated into the code in an effort to apply gpenelope as both an accurate and rapid dose validation system. A set of experimental measurements were performed on the MRIdian system to examine the accuracy of both the head model and gpenelope. Ultimately, gpenelope was applied toward independent validation of patient doses calculated by MRIdian’s kmc. Results: An acceleration factor of 152 was achieved in comparison to the original single-thread fortran implementation with the original accuracy being preserved. For 16 treatment plans including stomach (4), lung (2), liver (3), adrenal gland (2), pancreas (2), spleen(1), mediastinum (1), and breast (1), the MRIdian dose calculation engine agrees with gpenelope with a mean gamma passing rate of 99.1% ± 0.6% (2%/2 mm). Conclusions: A Monte Carlo simulation platform was developed based on a GPU- accelerated version of penelope. This platform was used to validate that both the vendor-provided head model and fast Monte Carlo engine used by the MRIdian system are accurate in modeling radiation transport in a patient using 2%/2 mm gamma criteria. Future applications of this

A GPU-accelerated Monte Carlo dose calculation platform and its application toward validating an MRI-guided radiation therapy beam model.

PubMed

Wang, Yuhe; Mazur, Thomas R; Green, Olga; Hu, Yanle; Li, Hua; Rodriguez, Vivian; Wooten, H Omar; Yang, Deshan; Zhao, Tianyu; Mutic, Sasa; Li, H Harold

2016-07-01

The clinical commissioning of IMRT subject to a magnetic field is challenging. The purpose of this work is to develop a GPU-accelerated Monte Carlo dose calculation platform based on penelope and then use the platform to validate a vendor-provided MRIdian head model toward quality assurance of clinical IMRT treatment plans subject to a 0.35 T magnetic field. penelope was first translated from fortran to c++ and the result was confirmed to produce equivalent results to the original code. The c++ code was then adapted to cuda in a workflow optimized for GPU architecture. The original code was expanded to include voxelized transport with Woodcock tracking, faster electron/positron propagation in a magnetic field, and several features that make gpenelope highly user-friendly. Moreover, the vendor-provided MRIdian head model was incorporated into the code in an effort to apply gpenelope as both an accurate and rapid dose validation system. A set of experimental measurements were performed on the MRIdian system to examine the accuracy of both the head model and gpenelope. Ultimately, gpenelope was applied toward independent validation of patient doses calculated by MRIdian's kmc. An acceleration factor of 152 was achieved in comparison to the original single-thread fortran implementation with the original accuracy being preserved. For 16 treatment plans including stomach (4), lung (2), liver (3), adrenal gland (2), pancreas (2), spleen(1), mediastinum (1), and breast (1), the MRIdian dose calculation engine agrees with gpenelope with a mean gamma passing rate of 99.1% ± 0.6% (2%/2 mm). A Monte Carlo simulation platform was developed based on a GPU- accelerated version of penelope. This platform was used to validate that both the vendor-provided head model and fast Monte Carlo engine used by the MRIdian system are accurate in modeling radiation transport in a patient using 2%/2 mm gamma criteria. Future applications of this platform will include dose validation and

A review of bioinformatics platforms for comparative genomics. Recent developments of the EDGAR 2.0 platform and its utility for taxonomic and phylogenetic studies.

PubMed

Yu, J; Blom, J; Glaeser, S P; Jaenicke, S; Juhre, T; Rupp, O; Schwengers, O; Spänig, S; Goesmann, A

2017-11-10

The rapid development of next generation sequencing technology has greatly increased the amount of available microbial genomes. As a result of this development, there is a rising demand for fast and automated approaches in analyzing these genomes in a comparative way. Whole genome sequencing also bears a huge potential for obtaining a higher resolution in phylogenetic and taxonomic classification. During the last decade, several software tools and platforms have been developed in the field of comparative genomics. In this manuscript, we review the most commonly used platforms and approaches for ortholog group analyses with a focus on their potential for phylogenetic and taxonomic research. Furthermore, we describe the latest improvements of the EDGAR platform for comparative genome analyses and present recent examples of its application for the phylogenomic analysis of different taxa. Finally, we illustrate the role of the EDGAR platform as part of the BiGi Center for Microbial Bioinformatics within the German network on Bioinformatics Infrastructure (de.NBI). Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Development of deployable structures for large space platform systems. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Greenberg, H. S.

1983-01-01

The preponderance of study effort was devoted toward the deployable platform systems study which culminated in the detailed design of a ground test article for future development testing. This design is representative of a prototype square-truss, single-fold building-block design that can construct deployable platform structures. This prototype design was selected through a comprehensive and traceable selection process applied to eight competitive designs. The selection process compared the competitive designs according to seven major selection criteria, i.e., design versatility, cost, thermal stability, meteoroid impact significance, reliability, performance predictability, and orbiter integration suitability. In support of the foregoing, a materials data base, and platform systems technology development needs were established. An erectable design of an OTV hangar was selected and recommended for further design development. This design was selected from five study-developed competitive single-fold and double-fold designs including hard-shell and inflatable designs. Also, two deployable manned module configurations, i.e., a hard-shell and an inflatable design were each developed to the same requirements as the composite of two Space station baseline habitat modules.

Feasibility of observer system for determining orientation of balloon borne observational platforms

NASA Technical Reports Server (NTRS)

Nigro, N. J.; Gagliardi, J. C.

1982-01-01

An observer model for predicting the orientation of balloon borne research platforms was developed. The model was employed in conjunction with data from the LACATE mission in order to determine the platform orientation as a function of time.

Investigating Students' Acceptance of a Statistics Learning Platform Using Technology Acceptance Model

ERIC Educational Resources Information Center

Song, Yanjie; Kong, Siu-Cheung

2017-01-01

The study aims at investigating university students' acceptance of a statistics learning platform to support the learning of statistics in a blended learning context. Three kinds of digital resources, which are simulations, online videos, and online quizzes, were provided on the platform. Premised on the technology acceptance model, we adopted a…

IntellWheels: modular development platform for intelligent wheelchairs.

PubMed

Braga, Rodrigo Antonio Marques; Petry, Marcelo; Reis, Luis Paulo; Moreira, António Paulo

2011-01-01

Intelligent wheelchairs (IWs) can become an important solution to the challenge of assisting individuals who have disabilities and are thus unable to perform their daily activities using classic powered wheelchairs. This article describes the concept and design of IntellWheels, a modular platform to facilitate the development of IWs through a multiagent system paradigm. In fact, modularity is achieved not only in the software perspective, but also through a generic hardware framework that was designed to fit, in a straightforward manner, almost any commercial powered wheelchair. Experimental results demonstrate the successful integration of all modules in the platform, providing safe motion to the IW. Furthermore, the results achieved with a prototype running in autonomous mode in simulated and mixed-reality environments also demonstrate the potential of our approach. Although some future research is still necessary to fully accomplish our objectives, preliminary tests have shown that IntellWheels will effectively reduce users' limitations, offering them a much more independent life.

Research the simulation model of the passenger travel behavior in urban rail platform

NASA Astrophysics Data System (ADS)

Wang, Yujia; Yin, Xiangyong

2017-05-01

Based on the results of the research on the platform of the Beijing Chegongzhuang subway station in the line 2, the passenger travel behavior in urban rail platform is divided into 4 parts, which are the enter passenger walking, the passenger waiting distribution and queuing up before the door, passenger boarding and alighting and the alighting passengers walking, according to the social force model, simulation model was built based on Matlab software. Combined with the actual data of subway the Chegongzhuang subway station in the line 2, the simulation results show that the social force model is effective.

Development of a WDM platform for charged-particle stopping experiments

DOE PAGES

Zylstra, A. B.; Frenje, J. A.; Grabowski, P. E.; ...

2016-05-26

A platform has been developed for generating large and relatively quiescent plasmas in the warm-dense matter (WDM) regime on the OMEGA laser facility. A cylindrical geometry is used to allow charged-particle probing along the axis. The plasma heating is radiative by L-shell emission generated on the outside of the cylinder. The cylinder drive is characterized with x-ray diagnostics. Possibilities for direct characterization of the plasma temperature are discussed. Lastly, the unimportance of electromagnetic fields around the target is demonstrated with proton radiography. We expect this platform to be used extensively in future experiments studying charged-particle stopping in this regime.

Multi-step high-throughput conjugation platform for the development of antibody-drug conjugates.

PubMed

Andris, Sebastian; Wendeler, Michaela; Wang, Xiangyang; Hubbuch, Jürgen

2018-07-20

Antibody-drug conjugates (ADCs) form a rapidly growing class of biopharmaceuticals which attracts a lot of attention throughout the industry due to its high potential for cancer therapy. They combine the specificity of a monoclonal antibody (mAb) and the cell-killing capacity of highly cytotoxic small molecule drugs. Site-specific conjugation approaches involve a multi-step process for covalent linkage of antibody and drug via a linker. Despite the range of parameters that have to be investigated, high-throughput methods are scarcely used so far in ADC development. In this work an automated high-throughput platform for a site-specific multi-step conjugation process on a liquid-handling station is presented by use of a model conjugation system. A high-throughput solid-phase buffer exchange was successfully incorporated for reagent removal by utilization of a batch cation exchange step. To ensure accurate screening of conjugation parameters, an intermediate UV/Vis-based concentration determination was established including feedback to the process. For conjugate characterization, a high-throughput compatible reversed-phase chromatography method with a runtime of 7 min and no sample preparation was developed. Two case studies illustrate the efficient use for mapping the operating space of a conjugation process. Due to the degree of automation and parallelization, the platform is capable of significantly reducing process development efforts and material demands and shorten development timelines for antibody-drug conjugates. Copyright © 2018 Elsevier B.V. All rights reserved.

The Prodiguer Messaging Platform

NASA Astrophysics Data System (ADS)

Greenslade, Mark; Denvil, Sebastien; Raciazek, Jerome; Carenton, Nicolas; Levavasseur, Guillame

2014-05-01

CONVERGENCE is a French multi-partner national project designed to gather HPC and informatics expertise to innovate in the context of running French climate models with differing grids and at differing resolutions. Efficient and reliable execution of these models and the management and dissemination of model output (data and meta-data) are just some of the complexities that CONVERGENCE aims to resolve. The Institut Pierre Simon Laplace (IPSL) is responsible for running climate simulations upon a set of heterogenous HPC environments within France. With heterogeneity comes added complexity in terms of simulation instrumentation and control. Obtaining a global perspective upon the state of all simulations running upon all HPC environments has hitherto been problematic. In this presentation we detail how, within the context of CONVERGENCE, the implementation of the Prodiguer messaging platform resolves complexity and permits the development of real-time applications such as: 1. a simulation monitoring dashboard; 2. a simulation metrics visualizer; 3. an automated simulation runtime notifier; 4. an automated output data & meta-data publishing pipeline; The Prodiguer messaging platform leverages a widely used open source message broker software called RabbitMQ. RabbitMQ itself implements the Advanced Message Queue Protocol (AMPQ). Hence it will be demonstrated that the Prodiguer messaging platform is built upon both open source and open standards.

Regional Crustal Velocity Models for Northern Arabian Platform and Turkish-Iranian Plateau

NASA Astrophysics Data System (ADS)

Aleqabi, G.; Wysession, M.; Ghalib, H.

2008-12-01

The geological structure of the Northern Arabian platform and surrounding mountains is dominated by the collision and suturing of the Arabian plate with the Eurasian plate and the formation of the Turkish-Iranian plateau. The structure of the Northern Arabian platform and surrounding region is poorly constrained. A recent deployment of 10 broadband seismometers in northern and central Iraq provides an opportunity to refine velocity models of the region. We have applied the Niching Genetic Algorithm waveform inversion technique to Rayleigh and Love waves traversing the Northern Arabian platform, the Zagros fold belt, the southern Turkish Plateau, the Iranian Plateau. Results show variations in crustal thickness and shear wave velocity between the Northern Arabian platform and the Turkish-Iranian plateau. In general the shear wave velocities are higher in the Northern Arabian platform than in the Plateaus. Variation of shear velocities within each of the provinces reflects the diversity in tectonic environment across the Zagros fold belt and the complex tectonic history of the region. Crustal thickness results show little crustal thickening has occurred due to collision.

A modular platform for targeted RNAi therapeutics.

PubMed

Kedmi, Ranit; Veiga, Nuphar; Ramishetti, Srinivas; Goldsmith, Meir; Rosenblum, Daniel; Dammes, Niels; Hazan-Halevy, Inbal; Nahary, Limor; Leviatan-Ben-Arye, Shani; Harlev, Michael; Behlke, Mark; Benhar, Itai; Lieberman, Judy; Peer, Dan

2018-03-01

Previous studies have identified relevant genes and signalling pathways that are hampered in human disorders as potential candidates for therapeutics. Developing nucleic acid-based tools to manipulate gene expression, such as short interfering RNAs 1-3 (siRNAs), opens up opportunities for personalized medicine. Yet, although major progress has been made in developing siRNA targeted delivery carriers, mainly by utilizing monoclonal antibodies (mAbs) for targeting 4-8 , their clinical translation has not occurred. This is in part because of the massive development and production requirements and the high batch-to-batch variability of current technologies, which rely on chemical conjugation. Here we present a self-assembled modular platform that enables the construction of a theoretically unlimited repertoire of siRNA targeted carriers. The self-assembly of the platform is based on a membrane-anchored lipoprotein that is incorporated into siRNA-loaded lipid nanoparticles that interact with the antibody crystallizable fragment (Fc) domain. We show that a simple switch of eight different mAbs redirects the specific uptake of siRNAs by diverse leukocyte subsets in vivo. The therapeutic potential of the platform is demonstrated in an inflammatory bowel disease model by targeting colon macrophages to reduce inflammatory symptoms, and in a Mantle Cell Lymphoma xenograft model by targeting cancer cells to induce cell death and improve survival. This modular delivery platform represents a milestone in the development of precision medicine.

A modular platform for targeted RNAi therapeutics

NASA Astrophysics Data System (ADS)

Kedmi, Ranit; Veiga, Nuphar; Ramishetti, Srinivas; Goldsmith, Meir; Rosenblum, Daniel; Dammes, Niels; Hazan-Halevy, Inbal; Nahary, Limor; Leviatan-Ben-Arye, Shani; Harlev, Michael; Behlke, Mark; Benhar, Itai; Lieberman, Judy; Peer, Dan

2018-01-01

Previous studies have identified relevant genes and signalling pathways that are hampered in human disorders as potential candidates for therapeutics. Developing nucleic acid-based tools to manipulate gene expression, such as short interfering RNAs1-3 (siRNAs), opens up opportunities for personalized medicine. Yet, although major progress has been made in developing siRNA targeted delivery carriers, mainly by utilizing monoclonal antibodies (mAbs) for targeting4-8, their clinical translation has not occurred. This is in part because of the massive development and production requirements and the high batch-to-batch variability of current technologies, which rely on chemical conjugation. Here we present a self-assembled modular platform that enables the construction of a theoretically unlimited repertoire of siRNA targeted carriers. The self-assembly of the platform is based on a membrane-anchored lipoprotein that is incorporated into siRNA-loaded lipid nanoparticles that interact with the antibody crystallizable fragment (Fc) domain. We show that a simple switch of eight different mAbs redirects the specific uptake of siRNAs by diverse leukocyte subsets in vivo. The therapeutic potential of the platform is demonstrated in an inflammatory bowel disease model by targeting colon macrophages to reduce inflammatory symptoms, and in a Mantle Cell Lymphoma xenograft model by targeting cancer cells to induce cell death and improve survival. This modular delivery platform represents a milestone in the development of precision medicine.

Tethys: A Platform for Water Resources Modeling and Decision Support Apps

NASA Astrophysics Data System (ADS)

Nelson, J.; Swain, N. R.

2015-12-01

The interactive nature of web applications or "web apps" makes it an excellent medium for conveying complex scientific concepts to lay audiences and creating decision support tools that harness cutting edge modeling techniques. However, the technical expertise required to develop web apps represents a barrier for would-be developers. This barrier can be characterized by the following hurdles that developers must overcome: (1) identify, select, and install software that meet the spatial and computational capabilities commonly required for water resources modeling; (2) orchestrate the use of multiple free and open source (FOSS) projects and navigate their differing application programming interfaces; (3) learn the multi-language programming skills required for modern web development; and (4) develop a web-secure and fully featured web portal to host the app. Tethys Platform has been developed to lower the technical barrier and minimize the initial development investment that prohibits many scientists and engineers from making use of the web app medium. It includes (1) a suite of FOSS that address the unique data and computational needs common to water resources web app development, (2) a Python software development kit that streamlines development, and (3) a customizable web portal that is used to deploy the completed web apps. Tethys synthesizes several software projects including PostGIS, 52°North WPS, GeoServer, Google Maps™, OpenLayers, and Highcharts. It has been used to develop a broad array of web apps for water resources modeling and decision support for several projects including CI-WATER, HydroShare, and the National Flood Interoperability Experiment. The presentation will include live demos of some of the apps that have been developed using Tethys to demonstrate its capabilities.

Power in the bucket and angle of arrival modelling in the presence of an airborne platform-induced turbulence

NASA Astrophysics Data System (ADS)

Velluet, Marie-Thérèse

2017-10-01

In the framework of a European collaborative research project called ALWS (Airborne platform effects on lasers and Warning Sensors), the effects of platform-related turbulence on MAWS (missile approach warning systems) and DIRCM (directed infrared countermeasures) performance are investigated. Field trials have been conducted to study the turbulence effects around a hovering helicopter and behind a turboprop aircraft on the ground, with engines running. The time dependence of the power in the bucket and the amplitude of the angle of arrival have been characterized during the trial. Temporal spectra of these two parameters present an asymptotic behavior typical of optical beams propagating through developed turbulence (Kolmogorov). Based on the formalism developed in the case of propagation through atmospheric turbulence, we have first estimated turbulence strength and wind velocity inside plume for different flight conditions. We have then proposed an approach to simulate times series of these two quantities in the same conditions. These simulated time series have been compared with the recorded data to assess their validity domain. This model will be integrated in a simulator to estimate the impact of the turbulence induced by the platform and calculate the system performance. In this model dedicated to plume and downwash effects, aero-optical effects are not taken into account.

Browser App Approach: Can It Be an Answer to the Challenges in Cross-Platform App Development?

ERIC Educational Resources Information Center

Huynh, Minh; Ghimire, Prashant

2017-01-01

Aim/Purpose: As smartphones proliferate, many different platforms begin to emerge. The challenge to developers as well as IS [Information Systems] educators and students is how to learn the skills to design and develop apps to run on cross-platforms. Background: For developers, the purpose of this paper is to describe an alternative to the complex…

SysFinder: A customized platform for search, comparison and assisted design of appropriate animal models based on systematic similarity.

PubMed

Yang, Shuang; Zhang, Guoqing; Liu, Wan; Wang, Zhen; Zhang, Jifeng; Yang, Dongshan; Chen, Y Eugene; Sun, Hong; Li, Yixue

2017-05-20

Animal models are increasingly gaining values by cross-comparisons of response or resistance to clinical agents used for patients. However, many disease mechanisms and drug effects generated from animal models are not transferable to human. To address these issues, we developed SysFinder (http://lifecenter.sgst.cn/SysFinder), a platform for scientists to find appropriate animal models for translational research. SysFinder offers a "topic-centered" approach for systematic comparisons of human genes, whose functions are involved in a specific scientific topic, to the corresponding homologous genes of animal models. Scientific topic can be a certain disease, drug, gene function or biological pathway. SysFinder calculates multi-level similarity indexes to evaluate the similarities between human and animal models in specified scientific topics. Meanwhile, SysFinder offers species-specific information to investigate the differences in molecular mechanisms between humans and animal models. Furthermore, SysFinder provides a user-friendly platform for determination of short guide RNAs (sgRNAs) and homology arms to design a new animal model. Case studies illustrate the ability of SysFinder in helping experimental scientists. SysFinder is a useful platform for experimental scientists to carry out their research in the human molecular mechanisms. Copyright © 2017 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

Reactions of Standing Bipeds on Moving Platforms to Keep Their Balance May Increase the Amplitude of Oscillations of Platforms Satisfying Hooke's Law.

PubMed

Goldsztein, Guillermo H

2016-01-01

Consider a person standing on a platform that oscillates laterally, i.e. to the right and left of the person. Assume the platform satisfies Hooke's law. As the platform moves, the person reacts and moves its body attempting to keep its balance. We develop a simple model to study this phenomenon and show that the person, while attempting to keep its balance, may do positive work on the platform and increase the amplitude of its oscillations. The studies in this article are motivated by the oscillations in pedestrian bridges that are sometimes observed when large crowds cross them.

Investigating the Nexus of Climate, Energy, Water, and Land at Decision-Relevant Scales: The Platform for Regional Integrated Modeling and Analysis (PRIMA)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kraucunas, Ian P.; Clarke, Leon E.; Dirks, James A.

2015-04-01

The Platform for Regional Integrated Modeling and Analysis (PRIMA) is an innovative modeling system developed at Pacific Northwest National Laboratory (PNNL) to simulate interactions among natural and human systems at scales relevant to regional decision making. PRIMA brings together state-of-the-art models of regional climate, hydrology, agriculture, socioeconomics, and energy systems using a flexible coupling approach. The platform can be customized to inform a variety of complex questions and decisions, such as the integrated evaluation of mitigation and adaptation options across a range of sectors. Research into stakeholder decision support needs underpins the platform's application to regional issues, including uncertainty characterization.more » Ongoing numerical experiments are yielding new insights into the interactions among human and natural systems on regional scales with an initial focus on the energy-land-water nexus in the upper U.S. Midwest. This paper focuses on PRIMA’s functional capabilities and describes some lessons learned to date about integrated regional modeling.« less

Development of biological platform for the autotrophic production of biofuels

NASA Astrophysics Data System (ADS)

Khan, Nymul

The research described herein is aimed at developing an advanced biofuel platform that has the potential to surpass the natural rate of solar energy capture and CO2 fixation. The underlying concept is to use the electricity from a renewable source, such as wind or solar, to capture CO 2 via a biological agent, such as a microbe, into liquid fuels that can be used for the transportation sector. In addition to being renewable, the higher rate of energy capture by photovoltaic cells than natural photosynthesis is expected to facilitate higher rate of liquid fuel production than traditional biofuel processes. The envisioned platform is part of ARPA-E's (Advanced Research Projects Agency - Energy) Electrofuels initiative which aims at supplementing the country's petroleum based fuel production with renewable liquid fuels that can integrate easily with the existing refining and distribution infrastructure (http://arpae. energy.gov/ProgramsProjects/Electrofuels.aspx). The Electrofuels initiative aimed to develop liquid biofuels that avoid the issues encountered in the current generation of biofuels: (1) the reliance of biomass-derived technologies on the inefficient process of photosynthesis, (2) the relatively energy- and resource-intensive nature of agronomic processes, and (3) the occupation of large areas of arable land for feedstock production. The process proceeds by the capture of solar energy into electrical energy via photovoltaic cells, using the generated electricity to split water into molecular hydrogen (H2) and oxygen (O2), and feeding these gases, along with carbon dioxide (CO2) emitted from point sources such as a biomass or coal-fired power plant, to a microbial bioprocessing platform. The proposed microbial bioprocessing platform leverages a chemolithoautotrophic microorganism (Rhodobacter capsulatus or Ralstonia eutropha) naturally able to utilize these gases as growth substrates, and genetically modified to produce a triterpene hydrocarbon fuel

A GPU-accelerated Monte Carlo dose calculation platform and its application toward validating an MRI-guided radiation therapy beam model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Yuhe; Mazur, Thomas R.; Green, Olga

Purpose: The clinical commissioning of IMRT subject to a magnetic field is challenging. The purpose of this work is to develop a GPU-accelerated Monte Carlo dose calculation platform based on PENELOPE and then use the platform to validate a vendor-provided MRIdian head model toward quality assurance of clinical IMRT treatment plans subject to a 0.35 T magnetic field. Methods: PENELOPE was first translated from FORTRAN to C++ and the result was confirmed to produce equivalent results to the original code. The C++ code was then adapted to CUDA in a workflow optimized for GPU architecture. The original code was expandedmore » to include voxelized transport with Woodcock tracking, faster electron/positron propagation in a magnetic field, and several features that make gPENELOPE highly user-friendly. Moreover, the vendor-provided MRIdian head model was incorporated into the code in an effort to apply gPENELOPE as both an accurate and rapid dose validation system. A set of experimental measurements were performed on the MRIdian system to examine the accuracy of both the head model and gPENELOPE. Ultimately, gPENELOPE was applied toward independent validation of patient doses calculated by MRIdian’s KMC. Results: An acceleration factor of 152 was achieved in comparison to the original single-thread FORTRAN implementation with the original accuracy being preserved. For 16 treatment plans including stomach (4), lung (2), liver (3), adrenal gland (2), pancreas (2), spleen(1), mediastinum (1), and breast (1), the MRIdian dose calculation engine agrees with gPENELOPE with a mean gamma passing rate of 99.1% ± 0.6% (2%/2 mm). Conclusions: A Monte Carlo simulation platform was developed based on a GPU- accelerated version of PENELOPE. This platform was used to validate that both the vendor-provided head model and fast Monte Carlo engine used by the MRIdian system are accurate in modeling radiation transport in a patient using 2%/2 mm gamma criteria. Future applications of

Development of an Integrated Process, Modeling and Simulation Platform for Performance-Based Design of Low-Energy and High IEQ Buildings

ERIC Educational Resources Information Center

Chen, Yixing

2013-01-01

The objective of this study was to develop a "Virtual Design Studio (VDS)": a software platform for integrated, coordinated and optimized design of green building systems with low energy consumption, high indoor environmental quality (IEQ), and high level of sustainability. The VDS is intended to assist collaborating architects,…

Developing Historic Building Information Modelling Guidelines and Procedures for Architectural Heritage in Ireland

NASA Astrophysics Data System (ADS)

Murphy, M.; Corns, A.; Cahill, J.; Eliashvili, K.; Chenau, A.; Pybus, C.; Shaw, R.; Devlin, G.; Deevy, A.; Truong-Hong, L.

2017-08-01

Cultural heritage researchers have recently begun applying Building Information Modelling (BIM) to historic buildings. The model is comprised of intelligent objects with semantic attributes which represent the elements of a building structure and are organised within a 3D virtual environment. Case studies in Ireland are used to test and develop the suitable systems for (a) data capture/digital surveying/processing (b) developing library of architectural components and (c) mapping these architectural components onto the laser scan or digital survey to relate the intelligent virtual representation of a historic structure (HBIM). While BIM platforms have the potential to create a virtual and intelligent representation of a building, its full exploitation and use is restricted to narrow set of expert users with access to costly hardware, software and skills. The testing of open BIM approaches in particular IFCs and the use of game engine platforms is a fundamental component for developing much wider dissemination. The semantically enriched model can be transferred into a WEB based game engine platform.

Space Science Cloud: a Virtual Space Science Research Platform Based on Cloud Model

NASA Astrophysics Data System (ADS)

Hu, Xiaoyan; Tong, Jizhou; Zou, Ziming

Through independent and co-operational science missions, Strategic Pioneer Program (SPP) on Space Science, the new initiative of space science program in China which was approved by CAS and implemented by National Space Science Center (NSSC), dedicates to seek new discoveries and new breakthroughs in space science, thus deepen the understanding of universe and planet earth. In the framework of this program, in order to support the operations of space science missions and satisfy the demand of related research activities for e-Science, NSSC is developing a virtual space science research platform based on cloud model, namely the Space Science Cloud (SSC). In order to support mission demonstration, SSC integrates interactive satellite orbit design tool, satellite structure and payloads layout design tool, payload observation coverage analysis tool, etc., to help scientists analyze and verify space science mission designs. Another important function of SSC is supporting the mission operations, which runs through the space satellite data pipelines. Mission operators can acquire and process observation data, then distribute the data products to other systems or issue the data and archives with the services of SSC. In addition, SSC provides useful data, tools and models for space researchers. Several databases in the field of space science are integrated and an efficient retrieve system is developing. Common tools for data visualization, deep processing (e.g., smoothing and filtering tools), analysis (e.g., FFT analysis tool and minimum variance analysis tool) and mining (e.g., proton event correlation analysis tool) are also integrated to help the researchers to better utilize the data. The space weather models on SSC include magnetic storm forecast model, multi-station middle and upper atmospheric climate model, solar energetic particle propagation model and so on. All the services above-mentioned are based on the e-Science infrastructures of CAS e.g. cloud storage and

Cross-Platform Development Techniques for Mobile Devices

DTIC Science & Technology

2013-09-01

many other platforms including Windows, Blackberry , and Symbian. Each of these platforms has their own distinct architecture and programming language...sales of iPhones and the increasing use of Android-based devices have forced less successful competitors such as Microsoft, Blackberry , and Symbian... Blackberry and Windows Phone are planned [12] in this tool’s attempt to reuse code with a unified JavaScript API while at the same time supporting unique

Crowd computing: using competitive dynamics to develop and refine highly predictive models.

PubMed

Bentzien, Jörg; Muegge, Ingo; Hamner, Ben; Thompson, David C

2013-05-01

A recent application of a crowd computing platform to develop highly predictive in silico models for use in the drug discovery process is described. The platform, Kaggle™, exploits a competitive dynamic that results in model optimization as the competition unfolds. Here, this dynamic is described in detail and compared with more-conventional modeling strategies. The complete and full structure of the underlying dataset is disclosed and some thoughts as to the broader utility of such 'gamification' approaches to the field of modeling are offered. Copyright © 2013 Elsevier Ltd. All rights reserved.

Development and Validation of a Novel Robotic Procedure Specific Simulation Platform: Partial Nephrectomy.

PubMed

Hung, Andrew J; Shah, Swar H; Dalag, Leonard; Shin, Daniel; Gill, Inderbir S

2015-08-01

We developed a novel procedure specific simulation platform for robotic partial nephrectomy. In this study we prospectively evaluate its face, content, construct and concurrent validity. This hybrid platform features augmented reality and virtual reality. Augmented reality involves 3-dimensional robotic partial nephrectomy surgical videos overlaid with virtual instruments to teach surgical anatomy, technical skills and operative steps. Advanced technical skills are assessed with an embedded full virtual reality renorrhaphy task. Participants were classified as novice (no surgical training, 15), intermediate (less than 100 robotic cases, 13) or expert (100 or more robotic cases, 14) and prospectively assessed. Cohort performance was compared with the Kruskal-Wallis test (construct validity). Post-study questionnaire was used to assess the realism of simulation (face validity) and usefulness for training (content validity). Concurrent validity evaluated correlation between virtual reality renorrhaphy task and a live porcine robotic partial nephrectomy performance (Spearman's analysis). Experts rated the augmented reality content as realistic (median 8/10) and helpful for resident/fellow training (8.0-8.2/10). Experts rated the platform highly for teaching anatomy (9/10) and operative steps (8.5/10) but moderately for technical skills (7.5/10). Experts and intermediates outperformed novices (construct validity) in efficiency (p=0.0002) and accuracy (p=0.002). For virtual reality renorrhaphy, experts outperformed intermediates on GEARS metrics (p=0.002). Virtual reality renorrhaphy and in vivo porcine robotic partial nephrectomy performance correlated significantly (r=0.8, p <0.0001) (concurrent validity). This augmented reality simulation platform displayed face, content and construct validity. Performance in the procedure specific virtual reality task correlated highly with a porcine model (concurrent validity). Future efforts will integrate procedure specific

Analysis of Surface Heterogeneity Effects with Mesoscale Terrestrial Modeling Platforms

NASA Astrophysics Data System (ADS)

Simmer, C.

2015-12-01

An improved understanding of the full variability in the weather and climate system is crucial for reducing the uncertainty in weather forecasting and climate prediction, and to aid policy makers to develop adaptation and mitigation strategies. A yet unknown part of uncertainty in the predictions from the numerical models is caused by the negligence of non-resolved land surface heterogeneity and the sub-surface dynamics and their potential impact on the state of the atmosphere. At the same time, mesoscale numerical models using finer horizontal grid resolution [O(1)km] can suffer from inconsistencies and neglected scale-dependencies in ABL parameterizations and non-resolved effects of integrated surface-subsurface lateral flow at this scale. Our present knowledge suggests large-eddy-simulation (LES) as an eventual solution to overcome the inadequacy of the physical parameterizations in the atmosphere in this transition scale, yet we are constrained by the computational resources, memory management, big-data, when using LES for regional domains. For the present, there is a need for scale-aware parameterizations not only in the atmosphere but also in the land surface and subsurface model components. In this study, we use the recently developed Terrestrial Systems Modeling Platform (TerrSysMP) as a numerical tool to analyze the uncertainty in the simulation of surface exchange fluxes and boundary layer circulations at grid resolutions of the order of 1km, and explore the sensitivity of the atmospheric boundary layer evolution and convective rainfall processes on land surface heterogeneity.

Applications integration in a hybrid cloud computing environment: modelling and platform

NASA Astrophysics Data System (ADS)

Li, Qing; Wang, Ze-yuan; Li, Wei-hua; Li, Jun; Wang, Cheng; Du, Rui-yang

2013-08-01

With the development of application services providers and cloud computing, more and more small- and medium-sized business enterprises use software services and even infrastructure services provided by professional information service companies to replace all or part of their information systems (ISs). These information service companies provide applications, such as data storage, computing processes, document sharing and even management information system services as public resources to support the business process management of their customers. However, no cloud computing service vendor can satisfy the full functional IS requirements of an enterprise. As a result, enterprises often have to simultaneously use systems distributed in different clouds and their intra enterprise ISs. Thus, this article presents a framework to integrate applications deployed in public clouds and intra ISs. A run-time platform is developed and a cross-computing environment process modelling technique is also developed to improve the feasibility of ISs under hybrid cloud computing environments.

Payao: a community platform for SBML pathway model curation

PubMed Central

Matsuoka, Yukiko; Ghosh, Samik; Kikuchi, Norihiro; Kitano, Hiroaki

2010-01-01

Summary: Payao is a community-based, collaborative web service platform for gene-regulatory and biochemical pathway model curation. The system combines Web 2.0 technologies and online model visualization functions to enable a collaborative community to annotate and curate biological models. Payao reads the models in Systems Biology Markup Language format, displays them with CellDesigner, a process diagram editor, which complies with the Systems Biology Graphical Notation, and provides an interface for model enrichment (adding tags and comments to the models) for the access-controlled community members. Availability and implementation: Freely available for model curation service at http://www.payaologue.org. Web site implemented in Seaser Framework 2.0 with S2Flex2, MySQL 5.0 and Tomcat 5.5, with all major browsers supported. Contact: kitano@sbi.jp PMID:20371497

Helicopters: The Platform of Choice for Defense and Development

DTIC Science & Technology

2013-04-25

FID effort by facilitating the IDAD tasks of balanced development, security, neutralization, and mobilization. In order to prevent instability...security, neutralization, and mobilization. In order to prevent instability inside a Host Nation (HN), it is important to build cohesive IDAD and...derived from the H -53 (arguably the oldest, biggest, and most cost-prohibitive platform of this type) compared to STOL-capable 4-9 passenger fixed wing

Modeling and Simulation of Offshore Wind Power Platform for 5 MW Baseline NREL Turbine.

PubMed

Roni Sahroni, Taufik

2015-01-01

This paper presents the modeling and simulation of offshore wind power platform for oil and gas companies. Wind energy has become the fastest growing renewable energy in the world and major gains in terms of energy generation are achievable when turbines are moved offshore. The objective of this project is to propose new design of an offshore wind power platform. Offshore wind turbine (OWT) is composed of three main structures comprising the rotor/blades, the tower nacelle, and the supporting structure. The modeling analysis was focused on the nacelle and supporting structure. The completed final design was analyzed using finite element modeling tool ANSYS to obtain the structure's response towards loading conditions and to ensure it complies with guidelines laid out by classification authority Det Norske Veritas. As a result, a new model of the offshore wind power platform for 5 MW Baseline NREL turbine was proposed.

Modeling and Simulation of Offshore Wind Power Platform for 5 MW Baseline NREL Turbine

PubMed Central

Roni Sahroni, Taufik

2015-01-01

This paper presents the modeling and simulation of offshore wind power platform for oil and gas companies. Wind energy has become the fastest growing renewable energy in the world and major gains in terms of energy generation are achievable when turbines are moved offshore. The objective of this project is to propose new design of an offshore wind power platform. Offshore wind turbine (OWT) is composed of three main structures comprising the rotor/blades, the tower nacelle, and the supporting structure. The modeling analysis was focused on the nacelle and supporting structure. The completed final design was analyzed using finite element modeling tool ANSYS to obtain the structure's response towards loading conditions and to ensure it complies with guidelines laid out by classification authority Det Norske Veritas. As a result, a new model of the offshore wind power platform for 5 MW Baseline NREL turbine was proposed. PMID:26550605

Free web-based modelling platform for managed aquifer recharge (MAR) applications

NASA Astrophysics Data System (ADS)

Stefan, Catalin; Junghanns, Ralf; Glaß, Jana; Sallwey, Jana; Fatkhutdinov, Aybulat; Fichtner, Thomas; Barquero, Felix; Moreno, Miguel; Bonilla, José; Kwoyiga, Lydia

2017-04-01

Managed aquifer recharge represents a valuable instrument for sustainable water resources management. The concept implies purposeful infiltration of surface water into underground for later recovery or environmental benefits. Over decades, MAR schemes were successfully installed worldwide for a variety of reasons: to maximize the natural storage capacity of aquifers, physical aquifer management, water quality management, and ecological benefits. The INOWAS-DSS platform provides a collection of free web-based tools for planning, management and optimization of main components of MAR schemes. The tools are grouped into 13 specific applications that cover most relevant challenges encountered at MAR sites, both from quantitative and qualitative perspectives. The applications include among others the optimization of MAR site location, the assessment of saltwater intrusion, the restoration of groundwater levels in overexploited aquifers, the maximization of natural storage capacity of aquifers, the improvement of water quality, the design and operational optimization of MAR schemes, clogging development and risk assessment. The platform contains a collection of about 35 web-based tools of various degrees of complexity, which are either included in application specific workflows or used as standalone modelling instruments. Among them are simple tools derived from data mining and empirical equations, analytical groundwater related equations, as well as complex numerical flow and transport models (MODFLOW, MT3DMS and SEAWAT). Up to now, the simulation core of the INOWAS-DSS, which is based on the finite differences groundwater flow model MODFLOW, is implemented and runs on the web. A scenario analyser helps to easily set up and evaluate new management options as well as future development such as land use and climate change and compare them to previous scenarios. Additionally simple tools such as analytical equations to assess saltwater intrusion are already running online

A Platform for Learning Internet of Things

ERIC Educational Resources Information Center

Bogdanovic, Zorica; Simic, Konstantin; Milutinovic, Miloš; Radenkovic, Božidar; Despotovic-Zrakic, Marijana

2014-01-01

This paper presents a model for conducting Internet of Things (IoT) classes based on a web-service oriented cloud platform. The goal of the designed model is to provide university students with knowledge about IoT concepts, possibilities, and business models, and allow them to develop basic system prototypes using general-purpose microdevices and…

Effect of wind gusts on the motion of a balloon-borne observation platform

NASA Technical Reports Server (NTRS)

Nigro, N. J.; Johanek, F. M.

1982-01-01

The effect of wind gusts on the magnitude of the pendulation angles of a balloon-borne observation platform is determined. A system mathematical model is developed and the solution of this model is used to determine the magnitude of the observation platforms pendulation angles.

Virus like particles as a platform for cancer vaccine development.

PubMed

Ong, Hui Kian; Tan, Wen Siang; Ho, Kok Lian

2017-01-01

Cancers have killed millions of people in human history and are still posing a serious health problem worldwide. Therefore, there is an urgent need for developing preventive and therapeutic cancer vaccines. Among various cancer vaccine development platforms, virus-like particles (VLPs) offer several advantages. VLPs are multimeric nanostructures with morphology resembling that of native viruses and are mainly composed of surface structural proteins of viruses but are devoid of viral genetic materials rendering them neither infective nor replicative. In addition, they can be engineered to display multiple, highly ordered heterologous epitopes or peptides in order to optimize the antigenicity and immunogenicity of the displayed entities. Like native viruses, specific epitopes displayed on VLPs can be taken up, processed, and presented by antigen-presenting cells to elicit potent specific humoral and cell-mediated immune responses. Several studies also indicated that VLPs could overcome the immunosuppressive state of the tumor microenvironment and break self-tolerance to elicit strong cytotoxic lymphocyte activity, which is crucial for both virus clearance and destruction of cancerous cells. Collectively, these unique characteristics of VLPs make them optimal cancer vaccine candidates. This review discusses current progress in the development of VLP-based cancer vaccines and some potential drawbacks of VLPs in cancer vaccine development. Extracellular vesicles with close resembling to viral particles are also discussed and compared with VLPs as a platform in cancer vaccine developments.

Year 2 Report: Protein Function Prediction Platform

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, C E

2012-04-27

Upon completion of our second year of development in a 3-year development cycle, we have completed a prototype protein structure-function annotation and function prediction system: Protein Function Prediction (PFP) platform (v.0.5). We have met our milestones for Years 1 and 2 and are positioned to continue development in completion of our original statement of work, or a reasonable modification thereof, in service to DTRA Programs involved in diagnostics and medical countermeasures research and development. The PFP platform is a multi-scale computational modeling system for protein structure-function annotation and function prediction. As of this writing, PFP is the only existing fullymore » automated, high-throughput, multi-scale modeling, whole-proteome annotation platform, and represents a significant advance in the field of genome annotation (Fig. 1). PFP modules perform protein functional annotations at the sequence, systems biology, protein structure, and atomistic levels of biological complexity (Fig. 2). Because these approaches provide orthogonal means of characterizing proteins and suggesting protein function, PFP processing maximizes the protein functional information that can currently be gained by computational means. Comprehensive annotation of pathogen genomes is essential for bio-defense applications in pathogen characterization, threat assessment, and medical countermeasure design and development in that it can short-cut the time and effort required to select and characterize protein biomarkers.« less

Evaluation of Smartphone Inertial Sensor Performance for Cross-Platform Mobile Applications

PubMed Central

Kos, Anton; Tomažič, Sašo; Umek, Anton

2016-01-01

Smartphone sensors are being increasingly used in mobile applications. The performance of sensors varies considerably among different smartphone models and the development of a cross-platform mobile application might be a very complex and demanding task. A publicly accessible resource containing real-life-situation smartphone sensor parameters could be of great help for cross-platform developers. To address this issue we have designed and implemented a pilot participatory sensing application for measuring, gathering, and analyzing smartphone sensor parameters. We start with smartphone accelerometer and gyroscope bias and noise parameters. The application database presently includes sensor parameters of more than 60 different smartphone models of different platforms. It is a modest, but important start, offering information on several statistical parameters of the measured smartphone sensors and insights into their performance. The next step, a large-scale cloud-based version of the application, is already planned. The large database of smartphone sensor parameters may prove particularly useful for cross-platform developers. It may also be interesting for individual participants who would be able to check-up and compare their smartphone sensors against a large number of similar or identical models. PMID:27049391

Evaluation of Game Engines for Cross-Platform Development of Mobile Serious Games for Health.

PubMed

Kleinschmidt, Carina; Haag, Martin

2016-01-01

Studies have shown that serious games for health can improve patient compliance and help to increase the quality of medical education. Due to a growing availability of mobile devices, especially the development of cross-platform mobile apps is helpful for improving healthcare. As the development can be highly time-consuming and expensive, an alternative development process is needed. Game engines are expected to simplify this process. Therefore, this article examines the question whether using game engines for cross-platform serious games for health can simplify the development compared to the development of a plain HTML5 app. At first, a systematic review of the literature was conducted in different databases (MEDLINE, ACM and IEEE). Afterwards three different game engines were chosen, evaluated in different categories and compared to the development of a HTML5 app. This was realized by implementing a prototypical application in the different engines and conducting a utility analysis. The evaluation shows that the Marmalade engine is the best choice for development in this scenario. Furthermore, it is obvious that the game engines have great benefits against plain HTML5 development as they provide components for graphics, physics, sounds, etc. The authors recommend to use the Marmalade Engine for a cross-platform mobile Serious Game for Health.

Reactions of Standing Bipeds on Moving Platforms to Keep Their Balance May Increase the Amplitude of Oscillations of Platforms Satisfying Hooke’s Law

PubMed Central

Goldsztein, Guillermo H.

2016-01-01

Consider a person standing on a platform that oscillates laterally, i.e. to the right and left of the person. Assume the platform satisfies Hooke’s law. As the platform moves, the person reacts and moves its body attempting to keep its balance. We develop a simple model to study this phenomenon and show that the person, while attempting to keep its balance, may do positive work on the platform and increase the amplitude of its oscillations. The studies in this article are motivated by the oscillations in pedestrian bridges that are sometimes observed when large crowds cross them. PMID:27304857

Public Health Platforms: An Emerging Informatics Approach to Health Professional Learning and Development

PubMed Central

Gray, Kathleen

2016-01-01

Health informatics has a major role to play in optimising the management and use of data, information and knowledge in health systems. As health systems undergo digital transformation, it is important to consider informatics approaches not only to curriculum content but also to the design of learning environments and learning activities for health professional learning and development. An example of such an informatics approach is the use of large-scale, integrated public health platforms on the Internet as part of health professional learning and development. This article describes selected examples of such platforms, with a focus on how they may influence the direction of health professional learning and development. Significance for public health The landscape of healthcare systems, public health systems, health research systems and professional education systems is fragmented, with many gaps and silos. More sophistication in the management of health data, information, and knowledge, based on public health informatics expertise, is needed to tackle key issues of prevention, promotion and policy-making. Platform technologies represent an emerging large-scale, highly integrated informatics approach to public health, combining the technologies of Internet, the web, the cloud, social technologies, remote sensing and/or mobile apps into an online infrastructure that can allow more synergies in work within and across these systems. Health professional curricula need updating so that the health workforce has a deep and critical understanding of the way that platform technologies are becoming the foundation of the health sector. PMID:27190977

Wireless Sensor Platform for Cultural Heritage Monitoring and Modeling System.

PubMed

Klein, Levente J; Bermudez, Sergio A; Schrott, Alejandro G; Tsukada, Masahiko; Dionisi-Vici, Paolo; Kargere, Lucretia; Marianno, Fernando; Hamann, Hendrik F; López, Vanessa; Leona, Marco

2017-08-31

Results from three years of continuous monitoring of environmental conditions using a wireless sensor platform installed at The Cloisters, the medieval branch of the New York Metropolitan Museum of Art, are presented. The platform comprises more than 200 sensors that were distributed in five galleries to assess temperature and air flow and to quantify microclimate changes using physics-based and statistical models. The wireless sensor network data shows a very stable environment within the galleries, while the dense monitoring enables localized monitoring of subtle changes in air quality trends and impact of visitors on the microclimate conditions. The high spatial and temporal resolution data serves as a baseline study to understand the impact of visitors and building operations on the long-term preservation of art objects.

[New model of doctor-nurse communication based on electronic medical advice platform].

PubMed

Cao, Yang; Ding, Aimin; Wang, Yan

2012-01-01

This article introduces a new model of the communication between doctors and nurses, with the aid of the electronic medical advice platform. This model has achieved good results in improving doctor and nurse's co-working efficiency, treating patients safely, preventing medical accidents, reducing medical errors and so on.

Modeling a maintenance simulation of the geosynchronous platform

NASA Technical Reports Server (NTRS)

Kleiner, A. F., Jr.

1980-01-01

A modeling technique used to conduct a simulation study comparing various maintenance routines for a space platform is dicussed. A system model is described and illustrated, the basic concepts of a simulation pass are detailed, and sections on failures and maintenance are included. The operation of the system across time is best modeled by a discrete event approach with two basic events - failure and maintenance of the system. Each overall simulation run consists of introducing a particular model of the physical system, together with a maintenance policy, demand function, and mission lifetime. The system is then run through many passes, each pass corresponding to one mission and the model is re-initialized before each pass. Statistics are compiled at the end of each pass and after the last pass a report is printed. Items of interest typically include the time to first maintenance, total number of maintenance trips for each pass, average capability of the system, etc.

Developing Swedish Spelling Exercises on the ICALL Platform Lärka

ERIC Educational Resources Information Center

Pijetlovic, Dijana; Volodina, Elena

2013-01-01

In this project we developed web services on the ICALL platform Lärka for automatic generation of Swedish spelling exercises using Text-To-Speech (TTS) technology which allows L2 learners to train their spelling and listening individually at home. The spelling exercises contain five different linguistic levels, whereby the language learner has the…

Development of a replacement AMLCD used on multiple platforms

NASA Astrophysics Data System (ADS)

Walsh, Kevin L.; Gobron, Robert

2002-08-01

A goal of military display users and manufacturers is commonality: to utilize a given display on as many platforms as possible. The often-addressed concern of obsolescence of commercial AMLCDs used on military programs becomes a key issue, though, with regard to commonality. Obsolescence occurs as the tools used in the manufacture of an AMLCD age and as new and improved materials and processes are developed. The LCD manufacturer, at some point, decides to cease the manufacture of a particular AMLCD. The users of that AMLCD then have two choices: make a lifetime buy of LCDs, or find a replacement. For a display which has achieved some degree of commonality, this choice must be faced by a number of different users on a number of platforms. This paper addresses some of the problems encountered when such a choice is made, as an SVGA display made by one manufacturer is replaced by an XGA display made by a different manufacturer.

Simulation Platform: a cloud-based online simulation environment.

PubMed

Yamazaki, Tadashi; Ikeno, Hidetoshi; Okumura, Yoshihiro; Satoh, Shunji; Kamiyama, Yoshimi; Hirata, Yutaka; Inagaki, Keiichiro; Ishihara, Akito; Kannon, Takayuki; Usui, Shiro

2011-09-01

For multi-scale and multi-modal neural modeling, it is needed to handle multiple neural models described at different levels seamlessly. Database technology will become more important for these studies, specifically for downloading and handling the neural models seamlessly and effortlessly. To date, conventional neuroinformatics databases have solely been designed to archive model files, but the databases should provide a chance for users to validate the models before downloading them. In this paper, we report our on-going project to develop a cloud-based web service for online simulation called "Simulation Platform". Simulation Platform is a cloud of virtual machines running GNU/Linux. On a virtual machine, various software including developer tools such as compilers and libraries, popular neural simulators such as GENESIS, NEURON and NEST, and scientific software such as Gnuplot, R and Octave, are pre-installed. When a user posts a request, a virtual machine is assigned to the user, and the simulation starts on that machine. The user remotely accesses to the machine through a web browser and carries out the simulation, without the need to install any software but a web browser on the user's own computer. Therefore, Simulation Platform is expected to eliminate impediments to handle multiple neural models that require multiple software. Copyright © 2011 Elsevier Ltd. All rights reserved.

Alginate based 3D hydrogels as an in vitro co-culture model platform for the toxicity screening of new chemical entities.

PubMed

Lan, Shih-Feng; Starly, Binil

2011-10-01

Prediction of human response to potential therapeutic drugs is through conventional methods of in vitro cell culture assays and expensive in vivo animal testing. Alternatives to animal testing require sophisticated in vitro model systems that must replicate in vivo like function for reliable testing applications. Advancements in biomaterials have enabled the development of three-dimensional (3D) cell encapsulated hydrogels as in vitro drug screening tissue model systems. In this study, we have developed an in vitro platform to enable high density 3D culture of liver cells combined with a monolayer growth of target breast cancer cell line (MCF-7) in a static environment as a representative example of screening drug compounds for hepatotoxicity and drug efficacy. Alginate hydrogels encapsulated with serial cell densities of HepG2 cells (10(5)-10(8) cells/ml) are supported by a porous poly-carbonate disc platform and co-cultured with MCF-7 cells within standard cell culture plates during a 3 day study period. The clearance rates of drug transformation by HepG2 cells are measured using a coumarin based pro-drug. The platform was used to test for HepG2 cytotoxicity 50% (CT(50)) using commercially available drugs which further correlated well with published in vivo LD(50) values. The developed test platform allowed us to evaluate drug dose concentrations to predict hepatotoxicity and its effect on the target cells. The in vitro 3D co-culture platform provides a scalable and flexible approach to test multiple-cell types in a hybrid setting within standard cell culture plates which may open up novel 3D in vitro culture techniques to screen new chemical entity compounds. Copyright © 2011 Elsevier Inc. All rights reserved.

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lowers the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, for installation on the south side of High Bay 3 in the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. In view below Platform C are several of the previously installed platforms. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Development of a Very Dense Liquid Cooled Compute Platform

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughes, Phillip N.; Lipp, Robert J.

2013-12-10

The objective of this project was to design and develop a prototype very energy efficient high density compute platform with 100% pumped refrigerant liquid cooling using commodity components and high volume manufacturing techniques. Testing at SLAC has indicated that we achieved a DCIE of 0.93 against our original goal of 0.85. This number includes both cooling and power supply and was achieved employing some of the highest wattage processors available.

Development of Oral Flexible Tablet (OFT) Formulation for Pediatric and Geriatric Patients: a Novel Age-Appropriate Formulation Platform.

PubMed

Chandrasekaran, Prabagaran; Kandasamy, Ruckmani

2017-08-01

Development of palatable formulations for pediatric and geriatric patients involves various challenges. However, an innovative development with beneficial characteristics of marketed formulations in a single formulation platform was attempted. The goal of this research was to develop solid oral flexible tablets (OFTs) as a platform for pediatrics and geriatrics as oral delivery is the most convenient and widely used mode of drug administration. For this purpose, a flexible tablet formulation using cetirizine hydrochloride as model stability labile class 1 and 3 drug as per the Biopharmaceutical Classification System was developed. Betadex, Eudragit E100, and polacrilex resin were evaluated as taste masking agents. Development work focused on excipient selection, formulation processing, characterization methods, stability, and palatability testing. Formulation with a cetirizine-to-polacrilex ratio of 1:2 to 1:3 showed robust physical strength with friability of 0.1% (w/w), rapid in vitro dispersion within 30 s in 2-6 ml of water, and 0.2% of total organic and elemental impurities. Polacrilex resin formulation shows immediate drug release within 30 min in gastric media, better taste masking, and acceptable stability. Hence, it is concluded that ion exchange resins can be appropriately used to develop taste-masked, rapidly dispersible, and stable tablet formulations with tailored drug release suitable for pediatrics and geriatrics. Flexible formulations can be consumed as swallowable, orally disintegrating, chewable, and as dispersible tablets. Flexibility in dose administration would improve compliance in pediatrics and geriatrics. This drug development approach using ion exchange resins can be a platform for formulating solid oral flexible drug products with low to medium doses.

Development of a Novel System to Measure a Clearance of a Passenger Platform

NASA Astrophysics Data System (ADS)

Shimizu, M.; Oizumi, J.; Matsuoka, R.; Takeda, H.; Okukura, H.; Ooya, A.; Koike, A.

2016-06-01

Clearances of a passenger platform at a railway station should be appropriately maintained for safety of both trains and passengers. In most Japanese railways clearances between a platform and a train car is measured precisely once or twice a year. Because current measurement systems operate on a track, the closure of the track is unavoidable. Since the procedure of the closure of a track is time-consuming and bothersome, we decided to develop a new system to measure clearances without the closure of a track. A new system is required to work on a platform and the required measurement accuracy is less than several millimetres. We have adopted a 3D laser scanner and stop-and-go operation for a new system. The current systems on a track measure clearances continuously at walking speed, while our system on a platform measures clearances at approximately ten metres intervals. The scanner controlled by a PC acquires a set of point data at each measuring station. Edge points of the platform, top and side points of two rails are detected from the acquired point data. Finally clearances of the platform are calculated by using the detected feature points of the platform and the rails. The results of an experiment using a prototype of our system show that the measurement accuracy by our system would be satisfactory, but our system would take more time than the current systems. Since our system requires no closure of a track, we conclude that our system would be convenient and effective.

Geospatial Service Platform for Education and Research

NASA Astrophysics Data System (ADS)

Gong, J.; Wu, H.; Jiang, W.; Guo, W.; Zhai, X.; Yue, P.

2014-04-01

We propose to advance the scientific understanding through applications of geospatial service platforms, which can help students and researchers investigate various scientific problems in a Web-based environment with online tools and services. The platform also offers capabilities for sharing data, algorithm, and problem-solving knowledge. To fulfil this goal, the paper introduces a new course, named "Geospatial Service Platform for Education and Research", to be held in the ISPRS summer school in May 2014 at Wuhan University, China. The course will share cutting-edge achievements of a geospatial service platform with students from different countries, and train them with online tools from the platform for geospatial data processing and scientific research. The content of the course includes the basic concepts of geospatial Web services, service-oriented architecture, geoprocessing modelling and chaining, and problem-solving using geospatial services. In particular, the course will offer a geospatial service platform for handson practice. There will be three kinds of exercises in the course: geoprocessing algorithm sharing through service development, geoprocessing modelling through service chaining, and online geospatial analysis using geospatial services. Students can choose one of them, depending on their interests and background. Existing geoprocessing services from OpenRS and GeoPW will be introduced. The summer course offers two service chaining tools, GeoChaining and GeoJModelBuilder, as instances to explain specifically the method for building service chains in view of different demands. After this course, students can learn how to use online service platforms for geospatial resource sharing and problem-solving.

Wireless Sensor Platform for Cultural Heritage Monitoring and Modeling System

PubMed Central

Bermudez, Sergio A.; Schrott, Alejandro G.; Tsukada, Masahiko; Kargere, Lucretia; Marianno, Fernando; Hamann, Hendrik F.; López, Vanessa; Leona, Marco

2017-01-01

Results from three years of continuous monitoring of environmental conditions using a wireless sensor platform installed at The Cloisters, the medieval branch of the New York Metropolitan Museum of Art, are presented. The platform comprises more than 200 sensors that were distributed in five galleries to assess temperature and air flow and to quantify microclimate changes using physics-based and statistical models. The wireless sensor network data shows a very stable environment within the galleries, while the dense monitoring enables localized monitoring of subtle changes in air quality trends and impact of visitors on the microclimate conditions. The high spatial and temporal resolution data serves as a baseline study to understand the impact of visitors and building operations on the long-term preservation of art objects. PMID:28858223

An Open Source modular platform for hydrological model implementation

NASA Astrophysics Data System (ADS)

Kolberg, Sjur; Bruland, Oddbjørn

2010-05-01

: Write or compile computer code, handle file IO for each modules, • Routine implementation and testing. Implementation of new process-simulating methods/equations, specialised objective functions or quality control routines, testing of these in an existing framework. o Need not: Implement user or model interface for the new routine, IO handling, administration of model setup and run, calibration and validation routines etc. From being developed for Norway's largest hydropower producer Statkraft, ENKI is now being turned into an Open Source project. At the time of writing, the licence and the project administration is not established. Also, it remains to port the application to other compilers and computer platforms. However, we hope that ENKI will prove useful for both academic and operational users.

A Platform-Independent Plugin for Navigating Online Radiology Cases.

PubMed

Balkman, Jason D; Awan, Omer A

2016-06-01

Software methods that enable navigation of radiology cases on various digital platforms differ between handheld devices and desktop computers. This has resulted in poor compatibility of online radiology teaching files across mobile smartphones, tablets, and desktop computers. A standardized, platform-independent, or "agnostic" approach for presenting online radiology content was produced in this work by leveraging modern hypertext markup language (HTML) and JavaScript web software technology. We describe the design and evaluation of this software, demonstrate its use across multiple viewing platforms, and make it publicly available as a model for future development efforts.

Content Management System for Developing a Virtual Platform for Association of Women's Aid with Lack of Resources

NASA Astrophysics Data System (ADS)

Sainz de Abajo, Beatriz; Flores García, Alberto; García Salcines, Enrique; Burón Fernández, F. Javier; López Coronado, Miguel; de Castro Lozano, Carlos

In this paper we show a Virtual Platform for an Association of Women's Aid called Centro Integral de Ayuda a la Mujer (CIAM). After analyzing different Content Management Systems (CMS) and the benefits that its use would contribute to the development of the Virtual Platform, taking into account the needs and requirements set by CIAM, we have opted for the use of Joomla!. This free CMS, for its characteristics, is the most benefits provided us. The virtual platform design has been developed following customer specifications, to have understood the simplicity and easy handling of the resulting platform. This platform will be integrated into the Web portal that has the Amarex Association and it will be able to be administrates from the CIAM without specific knowledge of programming languages. If new services were necessary, they would be easily implemented, adding new modules and components to perform these services.

Cloud Computing-based Platform for Drought Decision-Making using Remote Sensing and Modeling Products: Preliminary Results for Brazil

NASA Astrophysics Data System (ADS)

Vivoni, E.; Mascaro, G.; Shupe, J. W.; Hiatt, C.; Potter, C. S.; Miller, R. L.; Stanley, J.; Abraham, T.; Castilla-Rubio, J.

2012-12-01

Droughts and their hydrological consequences are a major threat to food security throughout the world. In arid and semiarid regions dependent on irrigated agriculture, prolonged droughts lead to significant and recurring economic and social losses. In this contribution, we present preliminary results on integrating a set of multi-resolution drought indices into a cloud computing-based visualization platform. We focused our initial efforts on Brazil due to a severe, on-going drought in a large agricultural area in the northeastern part of the country. The online platform includes drought products developed from: (1) a MODIS-based water stress index (WSI) based on inferences from normalized difference vegetation index and land surface temperature fields, (2) a volumetric water content (VWC) index obtained from application of the NASA CASA model, and (3) a set of AVHRR-based vegetation health indices obtained from NOAA/NESDIS. The drought indices are also presented in terms of anomalies with respect to a baseline period. Since our main objective is to engage stakeholders and decision-makers in Brazil, we incorporated other relevant geospatial data into the platform, including irrigation areas, dams and reservoirs, administrative units and annual climate information. We will also present a set of use cases developed to help stakeholders explore, query and provide feedback that allowed fine-tuning of the drought product delivery, presentation and analysis tools. Finally, we discuss potential next steps in development of the online platform, including applications at finer resolutions in specific basins and at a coarser global scale.

Developing Reliable Telemedicine Platforms with Unreliable and Limited Communication Bandwidth

DTIC Science & Technology

2017-10-01

hospital health care, the benefit of high -resolution medical data is greatly limited in battlefield or natural disaster areas, where communication to...sampling rate. For high - frequency data like waveforms, the downsampling approach could directly reduce the amount of data. Therefore, it could be used...AFRL-SA-WP-TR-2017-0019 Developing Reliable Telemedicine Platforms with Unreliable and Limited Communication Bandwidth Peter F

Platform C Installation

NASA Image and Video Library

2016-10-19

Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, a construction worker assist with the installation of the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket. The large bolts that hold the platform in place on the south wall are being secured. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C Installation

NASA Image and Video Library

2016-10-19

Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, construction workers assist with the installation of the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket. The large bolts that hold the platform in place on the south wall are being secured. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C Installation

NASA Image and Video Library

2016-10-19

Inside the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida, the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, has been installed on the south side of the high bay. In view below are several levels of previously installed platforms. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

A Structured and Unstructured grid Relocatable ocean platform for Forecasting (SURF)

NASA Astrophysics Data System (ADS)

Trotta, Francesco; Fenu, Elisa; Pinardi, Nadia; Bruciaferri, Diego; Giacomelli, Luca; Federico, Ivan; Coppini, Giovanni

2016-11-01

We present a numerical platform named Structured and Unstructured grid Relocatable ocean platform for Forecasting (SURF). The platform is developed for short-time forecasts and is designed to be embedded in any region of the large-scale Mediterranean Forecasting System (MFS) via downscaling. We employ CTD data collected during a campaign around the Elba island to calibrate and validate SURF. The model requires an initial spin up period of a few days in order to adapt the initial interpolated fields and the subsequent solutions to the higher-resolution nested grids adopted by SURF. Through a comparison with the CTD data, we quantify the improvement obtained by SURF model compared to the coarse-resolution MFS model.

Automated Platform Management System Scheduling

NASA Technical Reports Server (NTRS)

Hull, Larry G.

1990-01-01

The Platform Management System was established to coordinate the operation of platform systems and instruments. The management functions are split between ground and space components. Since platforms are to be out of contact with the ground more than the manned base, the on-board functions are required to be more autonomous than those of the manned base. Under this concept, automated replanning and rescheduling, including on-board real-time schedule maintenance and schedule repair, are required to effectively and efficiently meet Space Station Freedom mission goals. In a FY88 study, we developed several promising alternatives for automated platform planning and scheduling. We recommended both a specific alternative and a phased approach to automated platform resource scheduling. Our recommended alternative was based upon use of exactly the same scheduling engine in both ground and space components of the platform management system. Our phased approach recommendation was based upon evolutionary development of the platform. In the past year, we developed platform scheduler requirements and implemented a rapid prototype of a baseline platform scheduler. Presently we are rehosting this platform scheduler rapid prototype and integrating the scheduler prototype into two Goddard Space Flight Center testbeds, as the ground scheduler in the Scheduling Concepts, Architectures, and Networks Testbed and as the on-board scheduler in the Platform Management System Testbed. Using these testbeds, we will investigate rescheduling issues, evaluate operational performance and enhance the platform scheduler prototype to demonstrate our evolutionary approach to automated platform scheduling. The work described in this paper was performed prior to Space Station Freedom rephasing, transfer of platform responsibility to Code E, and other recently discussed changes. We neither speculate on these changes nor attempt to predict the impact of the final decisions. As a consequence some of our

Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf.

PubMed

Magella, Bliss; Adam, Mike; Potter, Andrew S; Venkatasubramanian, Meenakshi; Chetal, Kashish; Hay, Stuart B; Salomonis, Nathan; Potter, S Steven

2018-02-01

The developing kidney provides a useful model for study of the principles of organogenesis. In this report we use three independent platforms, Drop-Seq, Chromium 10x Genomics and Fluidigm C1, to carry out single cell RNA-Seq (scRNA-Seq) analysis of the E14.5 mouse kidney. Using the software AltAnalyze, in conjunction with the unsupervised approach ICGS, we were unable to identify and confirm the presence of 16 distinct cell populations during this stage of active nephrogenesis. Using a novel integrative supervised computational strategy, we were able to successfully harmonize and compare the cell profiles across all three technological platforms. Analysis of possible cross compartment receptor/ligand interactions identified the nephrogenic zone stroma as a source of GDNF. This was unexpected because the cap mesenchyme nephron progenitors had been thought to be the sole source of GDNF, which is a key driver of branching morphogenesis of the collecting duct system. The expression of Gdnf by stromal cells was validated in several ways, including Gdnf in situ hybridization combined with immunohistochemistry for SIX2, and marker of nephron progenitors, and MEIS1, a marker of stromal cells. Finally, the single cell gene expression profiles generated in this study confirmed and extended previous work showing the presence of multilineage priming during kidney development. Nephron progenitors showed stochastic expression of genes associated with multiple potential differentiation lineages. Copyright © 2017 Elsevier Inc. All rights reserved.

Updating the Micro-Tom TILLING platform.

PubMed

Okabe, Yoshihiro; Ariizumi, Tohru; Ezura, Hiroshi

2013-03-01

The dwarf tomato variety Micro-Tom is regarded as a model system for functional genomics studies in tomato. Various tomato genomic tools in the genetic background of Micro-Tom have been established, such as mutant collections, genome information and a metabolomic database. Recent advances in tomato genome sequencing have brought about a significant need for reverse genetics tools that are accessible to the larger community, because a great number of gene sequences have become available from public databases. To meet the requests from the tomato research community, we have developed the Micro-Tom Targeting-Induced Local Lesions IN Genomes (TILLING) platform, which is comprised of more than 5000 EMS-mutagenized lines. The platform serves as a reverse genetics tool for efficiently identifying mutant alleles in parallel with the development of Micro-Tom mutant collections. The combination of Micro-Tom mutant libraries and the TILLING approach enables researchers to accelerate the isolation of desirable mutants for unraveling gene function or breeding. To upgrade the genomic tool of Micro-Tom, the development of a new mutagenized population is underway. In this paper, the current status of the Micro-Tom TILLING platform and its future prospects are described.

SU-E-T-36: A GPU-Accelerated Monte-Carlo Dose Calculation Platform and Its Application Toward Validating a ViewRay Beam Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Y; Mazur, T; Green, O

Purpose: To build a fast, accurate and easily-deployable research platform for Monte-Carlo dose calculations. We port the dose calculation engine PENELOPE to C++, and accelerate calculations using GPU acceleration. Simulations of a Co-60 beam model provided by ViewRay demonstrate the capabilities of the platform. Methods: We built software that incorporates a beam model interface, CT-phantom model, GPU-accelerated PENELOPE engine, and GUI front-end. We rewrote the PENELOPE kernel in C++ (from Fortran) and accelerated the code on a GPU. We seamlessly integrated a Co-60 beam model (obtained from ViewRay) into our platform. Simulations of various field sizes and SSDs using amore » homogeneous water phantom generated PDDs, dose profiles, and output factors that were compared to experiment data. Results: With GPU acceleration using a dated graphics card (Nvidia Tesla C2050), a highly accurate simulation – including 100*100*100 grid, 3×3×3 mm3 voxels, <1% uncertainty, and 4.2×4.2 cm2 field size – runs 24 times faster (20 minutes versus 8 hours) than when parallelizing on 8 threads across a new CPU (Intel i7-4770). Simulated PDDs, profiles and output ratios for the commercial system agree well with experiment data measured using radiographic film or ionization chamber. Based on our analysis, this beam model is precise enough for general applications. Conclusions: Using a beam model for a Co-60 system provided by ViewRay, we evaluate a dose calculation platform that we developed. Comparison to measurements demonstrates the promise of our software for use as a research platform for dose calculations, with applications including quality assurance and treatment plan verification.« less

Development and Validation of an Interactive Internet Platform for Older People: The Healthy Ageing Through Internet Counselling in the Elderly Study.

PubMed

Jongstra, Susan; Beishuizen, Cathrien; Andrieu, Sandrine; Barbera, Mariagnese; van Dorp, Matthijs; van de Groep, Bram; Guillemont, Juliette; Mangialasche, Francesca; van Middelaar, Tessa; Moll van Charante, Eric; Soininen, Hilkka; Kivipelto, Miia; Richard, Edo

2017-02-01

A myriad of Web-based applications on self-management have been developed, but few focus on older people. In the face of global aging, older people form an important target population for cardiovascular prevention. This article describes the full development of an interactive Internet platform for older people, which was designed for the Healthy Ageing Through Internet Counselling in the Elderly (HATICE) study. We provide recommendations to design senior-friendly Web-based applications for a new approach to multicomponent cardiovascular prevention. The development of the platform followed five phases: (1) conceptual framework; (2) platform concept and functional design; (3) platform building (software and content); (4) testing and pilot study; and (5) final product. We performed a meta-analysis, reviewed guidelines for cardiovascular diseases, and consulted end users, experts, and software developers to create the platform concept and content. The software was built in iterative cycles. In the pilot study, 41 people aged ≥65 years used the platform for 8 weeks. Participants used the interactive features of the platform and appreciated the coach support. During all phases adjustments were made to incorporate all improvements from the previous phases. The final platform is a personal, secured, and interactive platform supported by a coach. When carefully designed, an interactive Internet platform is acceptable and feasible for use by older people with basic computer skills. To improve acceptability by older people, we recommend involving the end users in the process of development, to personalize the platform and to combine the application with human support. The interactive HATICE platform will be tested for efficacy in a multinational randomized controlled trial (ISRCTN48151589).

National Community Solar Platform

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rupert, Bart

This project was created to provide a National Community Solar Platform (NCSP) portal known as Community Solar Hub, that is available to any entity or individual who wants to develop community solar. This has been done by providing a comprehensive portal to make CEC’s solutions, and other proven community solar solutions, externally available for everyone to access – making the process easy through proven platforms to protect subscribers, developers and utilities. The successful completion of this project provides these tools via a web platform and integration APIs, a wide spectrum of community solar projects included in the platform, multiple groupsmore » of customers (utilities, EPCs, and advocates) using the platform to develop community solar, and open access to anyone interested in community solar. CEC’s Incubator project includes web-based informational resources, integrated systems for project information and billing systems, and engagement with customers and users by community solar experts. The combined effort externalizes much of Clean Energy Collective’s industry-leading expertise, allowing third parties to develop community solar without duplicating expensive start-up efforts. The availability of this platform creates community solar projects that are cheaper to build and cheaper to participate in, furthering the goals of DOE’s SunShot Initiative. Final SF 425 Final SF 428 Final DOE F 2050.11 Final Report Narrative« less

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lifts the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. Large Tandemloc bars have been attached to the platform to keep it level during lifting and installation. The C platform will be installed on the south side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Design and development of synthetic microbial platform cells for bioenergy

PubMed Central

Lee, Sang Jun; Lee, Sang-Jae; Lee, Dong-Woo

2013-01-01

The finite reservation of fossil fuels accelerates the necessity of development of renewable energy sources. Recent advances in synthetic biology encompassing systems biology and metabolic engineering enable us to engineer and/or create tailor made microorganisms to produce alternative biofuels for the future bio-era. For the efficient transformation of biomass to bioenergy, microbial cells need to be designed and engineered to maximize the performance of cellular metabolisms for the production of biofuels during energy flow. Toward this end, two different conceptual approaches have been applied for the development of platform cell factories: forward minimization and reverse engineering. From the context of naturally minimized genomes,non-essential energy-consuming pathways and/or related gene clusters could be progressively deleted to optimize cellular energy status for bioenergy production. Alternatively, incorporation of non-indigenous parts and/or modules including biomass-degrading enzymes, carbon uptake transporters, photosynthesis, CO2 fixation, and etc. into chassis microorganisms allows the platform cells to gain novel metabolic functions for bioenergy. This review focuses on the current progress in synthetic biology-aided pathway engineering in microbial cells and discusses its impact on the production of sustainable bioenergy. PMID:23626588

A Phase-Locked Loop Model of the Response of the Postural Control System to Periodic Platform Motion

PubMed Central

Schilling, Robert J.; Robinson, Charles J.

2010-01-01

A phase-locked loop (PLL) model of the response of the postural control system to periodic platform motion is proposed. The PLL model is based on the hypothesis that quiet standing (QS) postural sway can be characterized as a weak sinusoidal oscillation corrupted with noise. Because the signal to noise ratio is quite low, the characteristics of the QS oscillator are not measured directly from the QS sway, instead they are inferred from the response of the oscillator to periodic motion of the platform. When a sinusoidal stimulus is applied, the QS oscillator changes speed as needed until its frequency matches that of the platform, thus achieving phase lock in a manner consistent with a PLL control mechanism. The PLL model is highly effective in representing the frequency, amplitude, and phase shift of the sinusoidal component of the phase-locked response over a range of platform frequencies and amplitudes. Qualitative analysis of the PLL control mechanism indicates that there is a finite range of frequencies over which phase lock is possible, and that the size of this capture range decreases with decreasing platform amplitude. The PLL model was tested experimentally using nine healthy subjects and the results reveal good agreement with a mean phase shift error of 13.7° and a mean amplitude error of 0.8 mm. PMID:20378479

Development of a high-throughput microscale cell disruption platform for Pichia pastoris in rapid bioprocess design.

PubMed

Bláha, Benjamin A F; Morris, Stephen A; Ogonah, Olotu W; Maucourant, Sophie; Crescente, Vincenzo; Rosenberg, William; Mukhopadhyay, Tarit K

2018-01-01

The time and cost benefits of miniaturized fermentation platforms can only be gained by employing complementary techniques facilitating high-throughput at small sample volumes. Microbial cell disruption is a major bottleneck in experimental throughput and is often restricted to large processing volumes. Moreover, for rigid yeast species, such as Pichia pastoris, no effective high-throughput disruption methods exist. The development of an automated, miniaturized, high-throughput, noncontact, scalable platform based on adaptive focused acoustics (AFA) to disrupt P. pastoris and recover intracellular heterologous protein is described. Augmented modes of AFA were established by investigating vessel designs and a novel enzymatic pretreatment step. Three different modes of AFA were studied and compared to the performance high-pressure homogenization. For each of these modes of cell disruption, response models were developed to account for five different performance criteria. Using multiple responses not only demonstrated that different operating parameters are required for different response optima, with highest product purity requiring suboptimal values for other criteria, but also allowed for AFA-based methods to mimic large-scale homogenization processes. These results demonstrate that AFA-mediated cell disruption can be used for a wide range of applications including buffer development, strain selection, fermentation process development, and whole bioprocess integration. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:130-140, 2018. © 2017 American Institute of Chemical Engineers.

SEEK: a systems biology data and model management platform.

PubMed

Wolstencroft, Katherine; Owen, Stuart; Krebs, Olga; Nguyen, Quyen; Stanford, Natalie J; Golebiewski, Martin; Weidemann, Andreas; Bittkowski, Meik; An, Lihua; Shockley, David; Snoep, Jacky L; Mueller, Wolfgang; Goble, Carole

2015-07-11

Systems biology research typically involves the integration and analysis of heterogeneous data types in order to model and predict biological processes. Researchers therefore require tools and resources to facilitate the sharing and integration of data, and for linking of data to systems biology models. There are a large number of public repositories for storing biological data of a particular type, for example transcriptomics or proteomics, and there are several model repositories. However, this silo-type storage of data and models is not conducive to systems biology investigations. Interdependencies between multiple omics datasets and between datasets and models are essential. Researchers require an environment that will allow the management and sharing of heterogeneous data and models in the context of the experiments which created them. The SEEK is a suite of tools to support the management, sharing and exploration of data and models in systems biology. The SEEK platform provides an access-controlled, web-based environment for scientists to share and exchange data and models for day-to-day collaboration and for public dissemination. A plug-in architecture allows the linking of experiments, their protocols, data, models and results in a configurable system that is available 'off the shelf'. Tools to run model simulations, plot experimental data and assist with data annotation and standardisation combine to produce a collection of resources that support analysis as well as sharing. Underlying semantic web resources additionally extract and serve SEEK metadata in RDF (Resource Description Format). SEEK RDF enables rich semantic queries, both within SEEK and between related resources in the web of Linked Open Data. The SEEK platform has been adopted by many systems biology consortia across Europe. It is a data management environment that has a low barrier of uptake and provides rich resources for collaboration. This paper provides an update on the functions and

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lifts the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be installed on the south side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C Installation

NASA Image and Video Library

2016-10-19

A heavy-lift crane lifts the first half of the C-level work platforms, C south, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the south wall. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

EPOS Thematic Core Service ANTHROPOGENIC HAZARDS (TCS AH) - development of e-research platform

NASA Astrophysics Data System (ADS)

Orlecka-Sikora, Beata

2017-04-01

TCS AH is based on IS-EPOS Platform. The Platform facilitates research on anthropogenic hazards and is available online, free of charge https://tcs.ah-epos.eu/. The Platform is a final product of the IS-EPOS project, founded by the national programme - POIG - which was implemented in 2013-2015 (POIG.02.03.00-14-090/13-00). The platform is a result of a joint work of scientific community and industrial partners. Currently, the development of TCS AH is carried under EPOS IP project (H2020-INFRADEV-1-2015-1, INFRADEV-3-2015). Platform is an open virtual access point for researchers and Ph. D. students interested in anthropogenic seismicity and related hazards. This environment is designed to ensure a researcher the maximum possible liberty for experimentation by providing a virtual laboratory, in which the researcher can design own processing streams and process the data integrated on the platform. TCS AH integrates: data and specific high-level services. Data gathered in the so-called "episodes", comprehensively describing a geophysical process, induced or triggered by human technological activity, which, under certain circumstances can become hazardous for people, infrastructure and the environment. 7 sets of seismic, geological and technological data were made available on the Platform. The data come from Poland, Germany, UK and Vietnam, and refer to underground mining, reservoir impoundment, shale gas exploitation and geothermal energy production. The next at least 19 new episodes related to conventional hydrocarbon extraction, reservoir treatment, underground mining and geothermal energy production are being integrated within the framework of EPOS IP project. The heterogeneous multi-disciplinary data (seismic, displacement, geomechanical data, production data etc.) are transformed to unified structures to form integrated and validated datasets. To deal with this various data the problem-oriented services were designed and implemented. The particular attention

A Web-Based Modelling Platform for Interactive Exploration of Regional Responses to Global Change

NASA Astrophysics Data System (ADS)

Holman, I.

2014-12-01

Climate change adaptation is a complex human-environmental problem that is framed by the uncertainty in impacts and the adaptation choices available, but is also bounded by real-world constraints such as future resource availability and environmental and institutional capacities. Educating the next generation of informed decision-makers that will be able to make knowledgeable responses to global climate change impacts requires them to have access to information that is credible, accurate, easy to understand, and appropriate. However, available resources are too often produced by inaccessible models for scenario simulations chosen by researchers hindering exploration and enquiry. This paper describes the interactive exploratory web-based CLIMSAVE Integrated Assessment (IA) Platform (www.climsave.eu/iap) that aims to democratise climate change impacts, adaptation and vulnerability modelling. The regional version of the Platform contain linked simulation models (of the urban, agriculture, forestry, water and biodiversity sectors), probabilistic climate scenarios and socio-economic scenarios, that enable users to select their inputs (climate and socioeconomic), rapidly run the models using their input variable settings and view their chosen outputs. The interface of the CLIMSAVE IA Platform is designed to facilitate a two-way iterative process of dialogue and exploration of "what if's" to enable a wide range of users to improve their understanding surrounding impacts, adaptation responses and vulnerability of natural resources and ecosystem services under uncertain futures. This paper will describe the evolution of the Platform and demonstrate how using its holistic framework (multi sector / ecosystem service; cross-sectoral, climate and socio-economic change) will help to assist learning around the challenging concepts of responding to global change.

Robotic kidney autotransplantation in a porcine model: a procedure-specific training platform for the simulation of robotic intracorporeal vascular anastomosis.

PubMed

Tiong, Ho Yee; Goh, Benjamin Yen Seow; Chiong, Edmund; Tan, Lincoln Guan Lim; Vathsala, Anatharaman

2018-03-31

Robotic-assisted kidney transplantation (RKT) with the Da Vinci (Intuitive, USA) platform has been recently developed to improve outcomes by decreasing surgical site complications and morbidity, especially in obese patients. This potential paradigm shift in the surgical technique of kidney transplantation is performed in only a few centers. For wider adoption of this high stake complex operation, we aimed to develop a procedure-specific simulation platform in a porcine model for the training of robotic intracorporeal vascular anastomosis and evaluating vascular anastomoses patency. This paper describes the requirements and steps developed for the above training purpose. Over a series of four animal ethics' approved experiments, the technique of robotic-assisted laparoscopic autotransplantation of the kidney was developed in Amsterdam live pigs (60-70 kg). The surgery was based around the vascular anastomosis technique described by Menon et al. This non-survival porcine training model is targeted at transplant surgeons with robotic surgery experience. Under general anesthesia, each pig was placed in lateral decubitus position with the placement of one robotic camera port, two robotic 8 mm ports and one assistant port. Robotic docking over the pig posteriorly was performed. The training platform involved the following procedural steps. First, ipsilateral iliac vessel dissection was performed. Second, robotic-assisted laparoscopic donor nephrectomy was performed with in situ perfusion of the kidney with cold Hartmann's solution prior to complete division of the hilar vessels, ureter and kidney mobilization. Thirdly, the kidney was either kept in situ for orthotopic autotransplantation or mobilized to the pelvis and orientated for the vascular anastomosis, which was performed end to end or end to side after vessel loop clamping of the iliac vessels, respectively, using 6/0 Gore-Tex sutures. Following autotransplantation and release of vessel loops, perfusion of the

Information-computational platform for collaborative multidisciplinary investigations of regional climatic changes and their impacts

NASA Astrophysics Data System (ADS)

Gordov, Evgeny; Lykosov, Vasily; Krupchatnikov, Vladimir; Okladnikov, Igor; Titov, Alexander; Shulgina, Tamara

2013-04-01

Analysis of growing volume of related to climate change data from sensors and model outputs requires collaborative multidisciplinary efforts of researchers. To do it timely and in reliable way one needs in modern information-computational infrastructure supporting integrated studies in the field of environmental sciences. Recently developed experimental software and hardware platform Climate (http://climate.scert.ru/) provides required environment for regional climate change related investigations. The platform combines modern web 2.0 approach, GIS-functionality and capabilities to run climate and meteorological models, process large geophysical datasets and support relevant analysis. It also supports joint software development by distributed research groups, and organization of thematic education for students and post-graduate students. In particular, platform software developed includes dedicated modules for numerical processing of regional and global modeling results for consequent analysis and visualization. Also run of integrated into the platform WRF and «Planet Simulator» models, modeling results data preprocessing and visualization is provided. All functions of the platform are accessible by a user through a web-portal using common graphical web-browser in the form of an interactive graphical user interface which provides, particularly, capabilities of selection of geographical region of interest (pan and zoom), data layers manipulation (order, enable/disable, features extraction) and visualization of results. Platform developed provides users with capabilities of heterogeneous geophysical data analysis, including high-resolution data, and discovering of tendencies in climatic and ecosystem changes in the framework of different multidisciplinary researches. Using it even unskilled user without specific knowledge can perform reliable computational processing and visualization of large meteorological, climatic and satellite monitoring datasets through

Developing High-Throughput HIV Incidence Assay with Pyrosequencing Platform

PubMed Central

Park, Sung Yong; Goeken, Nolan; Lee, Hyo Jin; Bolan, Robert; Dubé, Michael P.

2014-01-01

ABSTRACT Human immunodeficiency virus (HIV) incidence is an important measure for monitoring the epidemic and evaluating the efficacy of intervention and prevention trials. This study developed a high-throughput, single-measure incidence assay by implementing a pyrosequencing platform. We devised a signal-masking bioinformatics pipeline, which yielded a process error rate of 5.8 × 10−4 per base. The pipeline was then applied to analyze 18,434 envelope gene segments (HXB2 7212 to 7601) obtained from 12 incident and 24 chronic patients who had documented HIV-negative and/or -positive tests. The pyrosequencing data were cross-checked by using the single-genome-amplification (SGA) method to independently obtain 302 sequences from 13 patients. Using two genomic biomarkers that probe for the presence of similar sequences, the pyrosequencing platform correctly classified all 12 incident subjects (100% sensitivity) and 23 of 24 chronic subjects (96% specificity). One misclassified subject's chronic infection was correctly classified by conducting the same analysis with SGA data. The biomarkers were statistically associated across the two platforms, suggesting the assay's reproducibility and robustness. Sampling simulations showed that the biomarkers were tolerant of sequencing errors and template resampling, two factors most likely to affect the accuracy of pyrosequencing results. We observed comparable biomarker scores between AIDS and non-AIDS chronic patients (multivariate analysis of variance [MANOVA], P = 0.12), indicating that the stage of HIV disease itself does not affect the classification scheme. The high-throughput genomic HIV incidence marks a significant step toward determining incidence from a single measure in cross-sectional surveys. IMPORTANCE Annual HIV incidence, the number of newly infected individuals within a year, is the key measure of monitoring the epidemic's rise and decline. Developing reliable assays differentiating recent from chronic

Design and Development of a Telerehabilitation Platform for Patients With Phantom Limb Pain: A User-Centered Approach.

PubMed

Rothgangel, Andreas; Braun, Susy; Smeets, Rob; Beurskens, Anna

2017-02-15

Phantom limb pain is a frequent and persistent problem following amputation. Achieving sustainable favorable effects on phantom limb pain requires therapeutic interventions such as mirror therapy that target maladaptive neuroplastic changes in the central nervous system. Unfortunately, patients' adherence to unsupervised exercises is generally poor and there is a need for effective strategies such as telerehabilitation to support long-term self-management of patients with phantom limb pain. The main aim of this study was to describe the user-centered approach that guided the design and development of a telerehabilitation platform for patients with phantom limb pain. We addressed 3 research questions: (1) Which requirements are defined by patients and therapists for the content and functions of a telerehabilitation platform and how can these requirements be prioritized to develop a first prototype of the platform? (2) How can the user interface of the telerehabilitation platform be designed so as to match the predefined critical user requirements and how can this interface be translated into a medium-fidelity prototype of the platform? (3) How do patients with phantom limb pain and their treating therapists judge the usability of the medium-fidelity prototype of the telerehabilitation platform in routine care and how can the platform be redesigned based on their feedback to achieve a high-fidelity prototype? The telerehabilitation platform was developed using an iterative user-centered design process. In the first phase, a questionnaire followed by a semistructured interview was used to identify the user requirements of both the patients and their physical and occupational therapists, which were then prioritized using a decision matrix. The second phase involved designing the interface of the telerehabilitation platform using design sketches, wireframes, and interface mock-ups to develop a low-fidelity prototype. Heuristic evaluation resulted in a medium

Design and Development of a Telerehabilitation Platform for Patients With Phantom Limb Pain: A User-Centered Approach

PubMed Central

2017-01-01

Background Phantom limb pain is a frequent and persistent problem following amputation. Achieving sustainable favorable effects on phantom limb pain requires therapeutic interventions such as mirror therapy that target maladaptive neuroplastic changes in the central nervous system. Unfortunately, patients’ adherence to unsupervised exercises is generally poor and there is a need for effective strategies such as telerehabilitation to support long-term self-management of patients with phantom limb pain. Objective The main aim of this study was to describe the user-centered approach that guided the design and development of a telerehabilitation platform for patients with phantom limb pain. We addressed 3 research questions: (1) Which requirements are defined by patients and therapists for the content and functions of a telerehabilitation platform and how can these requirements be prioritized to develop a first prototype of the platform? (2) How can the user interface of the telerehabilitation platform be designed so as to match the predefined critical user requirements and how can this interface be translated into a medium-fidelity prototype of the platform? (3) How do patients with phantom limb pain and their treating therapists judge the usability of the medium-fidelity prototype of the telerehabilitation platform in routine care and how can the platform be redesigned based on their feedback to achieve a high-fidelity prototype? Methods The telerehabilitation platform was developed using an iterative user-centered design process. In the first phase, a questionnaire followed by a semistructured interview was used to identify the user requirements of both the patients and their physical and occupational therapists, which were then prioritized using a decision matrix. The second phase involved designing the interface of the telerehabilitation platform using design sketches, wireframes, and interface mock-ups to develop a low-fidelity prototype. Heuristic evaluation

Control system design for the large space systems technology reference platform

NASA Technical Reports Server (NTRS)

Edmunds, R. S.

1982-01-01

Structural models and classical frequency domain control system designs were developed for the large space systems technology (LSST) reference platform which consists of a central bus structure, solar panels, and platform arms on which a variety of experiments may be mounted. It is shown that operation of multiple independently articulated payloads on a single platform presents major problems when subarc second pointing stability is required. Experiment compatibility will be an important operational consideration for systems of this type.

MathWorks Simulink and C++ integration with the new VLT PLC-based standard development platform for instrument control systems

NASA Astrophysics Data System (ADS)

Kiekebusch, Mario J.; Di Lieto, Nicola; Sandrock, Stefan; Popovic, Dan; Chiozzi, Gianluca

2014-07-01

ESO is in the process of implementing a new development platform, based on PLCs, for upcoming VLT control systems (new instruments and refurbishing of existing systems to manage obsolescence issues). In this context, we have evaluated the integration and reuse of existing C++ libraries and Simulink models into the real-time environment of BECKHOFF Embedded PCs using the capabilities of the latest version of TwinCAT software and MathWorks Embedded Coder. While doing so the aim was to minimize the impact of the new platform by adopting fully tested solutions implemented in C++. This allows us to reuse the in house expertise, as well as extending the normal capabilities of the traditional PLC programming environments. We present the progress of this work and its application in two concrete cases: 1) field rotation compensation for instrument tracking devices like derotators, 2) the ESO standard axis controller (ESTAC), a generic model-based controller implemented in Simulink and used for the control of telescope main axes.

Autonomous self-organizing resource manager for multiple networked platforms

NASA Astrophysics Data System (ADS)

Smith, James F., III

2002-08-01

A fuzzy logic based expert system for resource management has been developed that automatically allocates electronic attack (EA) resources in real-time over many dissimilar autonomous naval platforms defending their group against attackers. The platforms can be very general, e.g., ships, planes, robots, land based facilities, etc. Potential foes the platforms deal with can also be general. This paper provides an overview of the resource manager including the four fuzzy decision trees that make up the resource manager; the fuzzy EA model; genetic algorithm based optimization; co-evolutionary data mining through gaming; and mathematical, computational and hardware based validation. Methods of automatically designing new multi-platform EA techniques are considered. The expert system runs on each defending platform rendering it an autonomous system requiring no human intervention. There is no commanding platform. Instead the platforms work cooperatively as a function of battlespace geometry; sensor data such as range, bearing, ID, uncertainty measures for sensor output; intelligence reports; etc. Computational experiments will show the defending networked platform's ability to self- organize. The platforms' ability to self-organize is illustrated through the output of the scenario generator, a software package that automates the underlying data mining problem and creates a computer movie of the platforms' interaction for evaluation.

Development of Climate Change Adaptation Platform using Spatial Information

NASA Astrophysics Data System (ADS)

Lee, J.; Oh, K. Y.; Lee, M. J.; Han, W. J.

2014-12-01

Climate change adaptation has attracted growing attention with the recent extreme weather conditions that affect people around the world. More and more countries, including the Republic of Korea, have begun to hatch adaptation plan to resolve these matters of great concern. They all, meanwhile, have mentioned that it should come first to integrate climate information in all analysed areas. That's because climate information is not independently made through one source; that is to say, the climate information is connected one another in a complicated way. That is the reason why we have to promote integrated climate change adaptation platform before setting up climate change adaptation plan. Therefore, the large-scaled project has been actively launched and worked on. To date, we researched 620 literatures and interviewed 51 government organizations. Based on the results of the researches and interviews, we obtained 2,725 impacts about vulnerability assessment information such as Monitoring and Forecasting, Health, Disaster, Agriculture, Forest, Water Management, Ecosystem, Ocean/Fisheries, Industry/Energy. Among 2,725 impacts, 995 impacts are made into a database until now. This database is made up 3 sub categories like Climate-Exposure, Sensitivity, Adaptive capacity, presented by IPCC. Based on the constructed database, vulnerability assessments were carried out in order to evaluate climate change capacity of local governments all over the country. These assessments were conducted by using web-based vulnerability assessment tool which was newly developed through this project. These results have shown that, metropolitan areas like Seoul, Pusan, Inchon, and so on have high risks more than twice than rural areas. Acknowledgements: The authors appreciate the support that this study has received from "Development of integrated model for climate change impact and vulnerability assessment and strengthening the framework for model implementation ", an initiative of the

[Development and application of a medical device maintenance information platform based on BS architecture].

PubMed

Liu, Shenglin; Zhang, Xutian; Wang, Guohong; Zhang, Qiang

2012-03-01

Based on specified demands on medical devices maintenance for clinical engineers and Browser/Server architecture technology, a medical device maintenance information platform was developed, which implemented the following modules such as repair, preventive maintenance, accessories management, training, document, system management and regional cooperation. The characteristics of this system were summarized and application in increase of repair efficiency, improvement of preventive maintenance and cost control was introduced. The application of this platform increases medical device maintenance service level.

The Community Surface Dynamics Modeling System: Experiences on Building a Collaborative Modeling Platform

NASA Astrophysics Data System (ADS)

Overeem, I.; Hutton, E.; Kettner, A.; Peckham, S. D.; Syvitski, J. P.

2012-12-01

The Community Surface Dynamics Modeling System - CSDMS- develops a software platform with shared and coupled modules for modeling earth surface processes as a community resource. The framework allows prediction of water, sediment and nutrient transport through the landscape and seacape. The underlying paradigm is that the Earth surface we live on is a dynamic system; topography changes with seasons, with landslides and earthquakes, with erosion and deposition. The Earth Surface changes due to storms and floods, and important boundaries, like the coast, are ever-moving features. CSDMS sets out to make better predictions of these changes. Earth surface process modeling bridges the terrestrial, coastal and marine domains and requires understanding of the system over a range of time scales, which inherently needs interdisciplinarity. Members of CSDMS (~830 in July 2012) are largely from academic institutions (˜75%), followed by federal agencies (˜17%), and oil and gas companies (˜5%). Members and governmental bodies meet once annually and rely additionally on web-based information for communication. As an organization that relies on volunteer participation, CSDMS faces challenges to scientific collaboration. Encouraging volunteerism among its members to provide and adapt metadata and model code to be sufficiently standardized for coupling is crucial to building an integrated community modeling system. We here present CSDMS strategies aimed at providing the appropriate technical tools and cyberinfrastructure to support a variety of user types, ranging from advanced to novice modelers. Application of these advances in science is key, both into the educational realm and for managers and decision-makers. We discuss some of the implemented ideas to further organizational transparency and user engagement in small-scale governance, such as advanced trackers and voting systems for model development prioritization through the CSDMS wiki. We analyzed data on community

Platform based design of EAP transducers in Danfoss PolyPower A/S

NASA Astrophysics Data System (ADS)

Sarban, Rahimullah; Gudlaugsson, Tómas V.

2013-04-01

Electroactive Polymer (EAP) has gained increasing focus, in research communities, in last two decades. Research within the field of EAP has, so far, been mainly focused on material improvements, characterization, modeling and developing demonstrators. As the EAP technology matures, the need for a new area of research namely product development emerges. Product development can be based on an isolated design and production for a single product or platform design where a product family is developed. In platform design the families of products exploits commonality of platform modules while satisfying a variety of different market segments. Platform based approach has the primary benefit of being cost efficient and short lead time to market when new products emerges. Products development based on EAP technology is challenging both technologically as well as from production and processing point of view. Both the technological and processing challenges need to be addressed before a successful implementation of EAP technology into products. Based on this need Danfoss PolyPower A/S has, in 2011, launched a EAP platform project in collaboration with three Danish universities and three commercial organizations. The aim of the project is to develop platform based designs and product family for the EAP components to be used in variety of applications. This paper presents the structure of the platform project as a whole and specifically the platform based designs of EAP transducers. The underlying technologies, essential for EAP transducers, are also presented. Conceptual design and solution for the concepts are presented as well.

Establishing and Applying Criteria for Evaluating the Ease of Use of Dynamic Platforms for Teaching Web Application Development

ERIC Educational Resources Information Center

Dehinbo, Johnson

2011-01-01

The widespread use of the Internet and the World Wide Web led to the availability of many platforms for developing dynamic Web application and the problem of choosing the most appropriate platform that will be easy to use for undergraduate students of web applications development in tertiary institutions. Students beginning to learn web…

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle of the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. In view below Platform C are several of the previously installed platforms. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Evaluating the enhancement and improvement of China's technology and financial services platform innovation strategy.

PubMed

Wu, Ching-Sung; Hu, Kuang-Hua; Chen, Fu-Hsiang

2016-01-01

The development of high-tech industry has been prosperous around the world in past decades, while technology and finance have already become the most significant issues in the information era. While high-tech firms are a major force behind a country's economic development, it requires a lot of money for the development process, as well as the financing difficulties for its potential problems, thus, how to evaluate and establish appropriate technology and financial services platforms innovation strategy has become one of the most critical and difficult issues. Moreover, how the chosen intertwined financial environment can be optimized in order that high-tech firms financing problems can be decided has seldom been addressed. Thus, this research aims to establish a technology and financial services platform innovation strategy improvement model, as based on the hybrid MADM model, which addresses the main causal factors and amended priorities in order to strengthen ongoing planning. A DEMATEL technique, as based on Analytic Network Process, as well as modified VIKOR, will be proposed for selecting and re-configuring the aspired technology and financial services platform. An empirical study, as based on China's technology and financial services platform innovation strategy, will be provided for verifying the effectiveness of this proposed methodology. Based on expert interviews, technology and financial services platforms innovation strategy improvement should be made in the following order: credit guarantee platform ( C )_credit rating platform ( B )_investment and finance platform ( A ).

Addressing Hydro-economic Modeling Limitations - A Limited Foresight Sacramento Valley Model and an Open-source Modeling Platform

NASA Astrophysics Data System (ADS)

Harou, J. J.; Hansen, K. M.

2008-12-01

Increased scarcity of world water resources is inevitable given the limited supply and increased human pressures. The idea that "some scarcity is optimal" must be accepted for rational resource use and infrastructure management decisions to be made. Hydro-economic systems models are unique at representing the overlap of economic drivers, socio-political forces and distributed water resource systems. They demonstrate the tangible benefits of cooperation and integrated flexible system management. Further improvement of models, quality control practices and software will be needed for these academic policy tools to become accepted into mainstream water resource practice. Promising features include: calibration methods, limited foresight optimization formulations, linked simulation-optimization approaches (e.g. embedding pre-existing calibrated simulation models), spatial groundwater models, stream-aquifer interactions and stream routing, etc.. Conventional user-friendly decision support systems helped spread simulation models on a massive scale. Hydro-economic models must also find a means to facilitate construction, distribution and use. Some of these issues and model features are illustrated with a hydro-economic optimization model of the Sacramento Valley. Carry-over storage value functions are used to limit hydrologic foresight of the multi- period optimization model. Pumping costs are included in the formulation by tracking regional piezometric head of groundwater sub-basins. To help build and maintain this type of network model, an open-source water management modeling software platform is described and initial project work is discussed. The objective is to generically facilitate the connection of models, such as those developed in a modeling environment (GAMS, MatLab, Octave, "), to a geographic user interface (drag and drop node-link network) and a database (topology, parameters and time series). These features aim to incrementally move hydro- economic models

An Overview of Coral Community Development on Offshore Platforms in the Gulf of Mexico

NASA Astrophysics Data System (ADS)

Sammarco, P. W.

2016-02-01

Oil platforms in the N. Gulf of Mexico (GOM) number 1,750, providing hard substratum for settlement of marine fauna, including corals, where little existed in shallow water prior to the 1940s. The introduction of hard substratum has facilitated the biogeographic expansion of Caribbean reef corals. We surveyed scleractinian corals, hermatypic and ahermatypic, on 48 platforms around the Flower Garden Banks (FGB) and across the continental shelf, from Corpus Christi, Texas to Mobile, Alabama, USA. We also assessed coral populations on platforms and the FGB for genetic affinities using AFLPs. The western limit for hermatypes was the shelf edge off Corpus Christi. The highest hermatypic densities occurred at the shelf edge, 200 km from shore in the north-central GOM. Mobile was the eastern limit for some hermatypic corals. Ahermatypes (i.e., Tubastraea coccinea, Oculina diffusa, Phyllangia americana) were absent inshore and in the north-central GOM. Species richness of hermatypic corals peaked near the FGB. Genetic analyses revealed high self-recognition and site fidelity on the platforms and the FGB in Madracis decactis, particularly in the eastern GOM. Platform populations exhibited a strong genetic affinity to those on the FGB, indicating that the FGB are the likely larval source for many corals on the platforms. There was little or no genetic affinity of coral populations across the mouth of the Mississippi River, although in T. coccinea (invasive species), cross-recognition between populations was higher between platforms on a given side. The Mississippi is a strong geographic barrier to east-west dispersal. Brooders were found to be more effective at colonizing patchy habitats at this meso-scale than broadcasters (Diploria strigosa and Montastraea cavernosa). Broadcaster recruits were rarely found, indicating less effective dispersal capabilities. Oil/gas platforms have facilitated the development of coral communities across the northern GOM.

Architecture of a platform for hardware-in-the-loop simulation of flying vehicle control systems

NASA Astrophysics Data System (ADS)

Belokon', S. A.; Zolotukhin, Yu. N.; Filippov, M. N.

2017-07-01

A hardware-software platform is presented, which is designed for the development and hardware-in-the-loop simulation of flying vehicle control systems. This platform ensures the construction of the mathematical model of the plant, development of algorithms and software for onboard radioelectronic equipment and ground control station, and visualization of the three-dimensional model of the vehicle and external environment of the cockpit in the simulator training mode.

A tutorial platform suitable for surgical simulator training (SimMentor).

PubMed

Røtnes, Jan Sigurd; Kaasa, Johannes; Westgaard, Geir; Eriksen, Eivind Myrold; Hvidsten, Per Oyvind; Strøm, Kyrre; Sørhus, Vidar; Halbwachs, Yvon; Haug, Einar; Grimnes, Morten; Fontenelle, Hugues; Ekeberg, Tom; Thomassen, Jan B; Elle, Ole Jakob; Fosse, Erik

2002-01-01

The introduction of simulators in surgical training entails the need to develop pedagogic platforms adapted to the potentials and limitations provided by the information technology. As a solution to the technical challenges in treating all possible interaction events and to obtain a suitable pedagogic approach, we have developed a pedagogic platform for surgical training, SimMentor. In SimMentor the procedure to be practiced is divided into a number of natural phases. The trainee will practice on one phase at a time, however he can select the sequence of phases arbitrarily. A phase is taught by letting the trainee alternate freely between 2 modes: 1: A 3-dimensional animated guidance designed for learning the objectives and challenges in a procedure. 2: An interactive training session through the instrument manipulator device designed for training motoric responses based on visual and tactile responses produced by the simulator. The two modes are interfaced with the same virtual reality platform, thus SimMentor allows a seamless transition between the modes. We have developed a prototype simulator for robotic assisted endoscopic CABG (Coronary Artery Bypass Grafting) procedure by first focusing on the anastomosis part of the operation. Tissue, suture and instrument models have been developed and integrated with a simulated model of a beating heart comprises the elements in the simulator engine that is used in construction a training platform for learning different methods for performing a coronary anastomosis procedure. The platform is designed for integrating the following features: 1) practical approach to handle interactivity events with flexible-objects 3D simulators, 2) methods for quantitative evaluations of performance, 3) didactic presentations, 4) effective ways of producing diversity of clinical and pathological training scenarios.

Critical stages of a biodetection platform development from sensor chip fabrication to surface chemistry and assay development

NASA Astrophysics Data System (ADS)

Uludag, Yildiz

2014-06-01

Once viewed solely as a tool to analyse biomolecular interactions, biosensors are gaining widespread interest for diagnostics, biological defense, environmental and quality assurance in agriculture/food industries. Advanced micro fabrication techniques have facilitated integration of microfluidics with sensing functionalities on the same chip making system automation more convenient1. Biosensor devices relying on lab-on-a-chip technologies and nanotechnology has attracted much of attention in recent years for biological defense research and development. However, compared with the numerous publications and patents available, the commercialization of biosensors technology has significantly lagged behind the research output. This paper reviews the reasons behind the slow commercialisation of biosensors with an insight to the critical stages of a biosensor development from the sensor chip fabrication to surface chemistry applications and nanotechnology applications in sensing with case studies. In addition, the paper includes the description of a new biodetection platform based on Real-time Electrochemical ProfilingTM (REPTM) that comprises novel electrode arrays and nanoparticle based sensing. The performance of the REPTM platform has been tested for the detection of Planktothrix agardhii, one of the toxic bloom-forming cyanobacteria, usually found in shallow fresh water sources that can be used for human consumption. The optimised REPTM assay allowed the detection of P. agardhii DNA down to 6 pM. This study, showed the potential of REPTM as a new biodetection platform for toxic bacteria and hence further studies will involve the development of a portable multi-analyte biosensor based on REPTM technology for on-site testing.

A Standard-Based Model for Adaptive E-Learning Platform for Mauritian Academic Institutions

ERIC Educational Resources Information Center

Kanaksabee, P.; Odit, M. P.; Ramdoyal, A.

2011-01-01

The key aim of this paper is to introduce a standard-based model for adaptive e-learning platform for Mauritian academic institutions and to investigate the conditions and tools required to implement this model. The main forces of the system are that it allows collaborative learning, communication among user, and reduce considerable paper work.…

Development Model for Research Infrastructures

NASA Astrophysics Data System (ADS)

Wächter, Joachim; Hammitzsch, Martin; Kerschke, Dorit; Lauterjung, Jörn

2015-04-01

Research infrastructures (RIs) are platforms integrating facilities, resources and services used by the research communities to conduct research and foster innovation. RIs include scientific equipment, e.g., sensor platforms, satellites or other instruments, but also scientific data, sample repositories or archives. E-infrastructures on the other hand provide the technological substratum and middleware to interlink distributed RI components with computing systems and communication networks. The resulting platforms provide the foundation for the design and implementation of RIs and play an increasing role in the advancement and exploitation of knowledge and technology. RIs are regarded as essential to achieve and maintain excellence in research and innovation crucial for the European Research Area (ERA). The implementation of RIs has to be considered as a long-term, complex development process often over a period of 10 or more years. The ongoing construction of Spatial Data Infrastructures (SDIs) provides a good example for the general complexity of infrastructure development processes especially in system-of-systems environments. A set of directives issued by the European Commission provided a framework of guidelines for the implementation processes addressing the relevant content and the encoding of data as well as the standards for service interfaces and the integration of these services into networks. Additionally, a time schedule for the overall construction process has been specified. As a result this process advances with a strong participation of member states and responsible organisations. Today, SDIs provide the operational basis for new digital business processes in both national and local authorities. Currently, the development of integrated RIs in Earth and Environmental Sciences is characterised by the following properties: • A high number of parallel activities on European and national levels with numerous institutes and organisations participating

Recent carbonate sedimentation on Balearic platform: model for temperate-climate carbonate shelves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fornos, J.; Rodriguez-Perea, A.; Massuti, C.

Existing models for carbonate sedimentation on continental platforms are derived from the study of modern carbonate platforms in tropical climates. The Balearic platform in the western Mediterranean provides a new model for carbonate sedimentation in a temperature, semiarid climate. On most of the continental shelf around the Balearic Islands, modern sediments are exclusively bioclastic carbonates. Shoreline carbonate sediments are bioclastic sands and muds accumulating in beach-dune systems without significant tidal influence (there are no astronomical tides in the western Mediterranean ). From the upper shoreface to 35 m deep, the sandy bottom is extensively colonized by sea grass (Posidonia oceanica),more » the rhizomes and roots of which form a rigid entrapment that retains the sediment derived from calcareous organisms living within the sea grass and from calcareous epiphytes living on the stems and leaves. Archeological dating establishes a rate of vertical accretion in this zone of 10/sup 3/ Bubnoff units (1 Bubnoff unit = 1 mm/1000 years). Between depths of 40 and 60 m, carbonate sands are composed predominantly or red-algal fragments. Intensely bioturbated wave ripples occur in environments dominated by laminar red algae (Lithothamnium and Phymatolithon). Below depths of 60 m, coarse sediment produced by rhodolitic and ramose red algae is deposited in areas of tens to hundreds of meters in size. Biogenic buildups up to 2 m high occur in sandy areas as well as in deeper muddy areas. At the same depth in open-platform zones, the bottom topography is characterized by large hummocks several hundred meters across. From the horizontal distribution of facies, it is possible to construct the probable vertical sequence of lithofacies which would characterize carbonates accumulating on a temperate-climate carbonate shelf. Many of these lithofacies are recognized in upper Miocene limestones on the Balearic Islands.« less

Publishing Platform for Scientific Software - Lessons Learned

NASA Astrophysics Data System (ADS)

Hammitzsch, Martin; Fritzsch, Bernadette; Reusser, Dominik; Brembs, Björn; Deinzer, Gernot; Loewe, Peter; Fenner, Martin; van Edig, Xenia; Bertelmann, Roland; Pampel, Heinz; Klump, Jens; Wächter, Joachim

2015-04-01

Scientific software has become an indispensable commodity for the production, processing and analysis of empirical data but also for modelling and simulation of complex processes. Software has a significant influence on the quality of research results. For strengthening the recognition of the academic performance of scientific software development, for increasing its visibility and for promoting the reproducibility of research results, concepts for the publication of scientific software have to be developed, tested, evaluated, and then transferred into operations. For this, the publication and citability of scientific software have to fulfil scientific criteria by means of defined processes and the use of persistent identifiers, similar to data publications. The SciForge project is addressing these challenges. Based on interviews a blueprint for a scientific software publishing platform and a systematic implementation plan has been designed. In addition, the potential of journals, software repositories and persistent identifiers have been evaluated to improve the publication and dissemination of reusable software solutions. It is important that procedures for publishing software as well as methods and tools for software engineering are reflected in the architecture of the platform, in order to improve the quality of the software and the results of research. In addition, it is necessary to work continuously on improving specific conditions that promote the adoption and sustainable utilization of scientific software publications. Among others, this would include policies for the development and publication of scientific software in the institutions but also policies for establishing the necessary competencies and skills of scientists and IT personnel. To implement the concepts developed in SciForge a combined bottom-up / top-down approach is considered that will be implemented in parallel in different scientific domains, e.g. in earth sciences, climate research and

A digital peer-to-peer learning platform for clinical skills development.

PubMed

Basnak, Jesse; Ortynski, Jennifer; Chow, Meghan; Nzekwu, Emeka

2017-02-01

Due to constraints in time and resources, medical curricula may not provide adequate opportunities for pre-clerkship students to practice clinical skills. To address this, medical students at the University of Alberta developed a digital peer-to-peer learning initiative. The initiative assessed if students can learn clinical skills from their peers in co-curricular practice objective structured clinical exams (OSCEs). A total of 144 first-year medical students participated. Students wrote case scenarios that were reviewed by physicians. Students enacted the cases in practice OSCEs, acting as the patient, physician, and evaluator. Verbal and electronic evaluations were completed. A digital platform was used to automate the process. Surveys were disseminated to assess student perceptions of their experience. Seventy-five percent of participants said they needed opportunities to practice patient histories and physical exams in addition to those provided in the medical school curriculum. All participants agreed that the co-curricular practice OSCEs met this need. The majority of participants also agreed that the digital platform was efficient and easy to use. Students found the practice OSCEs and digital platform effective for learning clinical skills. Thus, peer-to-peer learning and computer automation can be useful adjuncts to traditional medical curricula.

The "Vsoil Platform" : a tool to integrate the various physical, chemical and biological processes contributing to the soil functioning at the local scale.

NASA Astrophysics Data System (ADS)

Lafolie, François; Cousin, Isabelle; Mollier, Alain; Pot, Valérie; Moitrier, Nicolas; Balesdent, Jérome; bruckler, Laurent; Moitrier, Nathalie; Nouguier, Cédric; Richard, Guy

2014-05-01

Models describing the soil functioning are valuable tools for addressing challenging issues related to agricultural production, soil protection or biogeochemical cycles. Coupling models that address different scientific fields is actually required in order to develop numerical tools able to simulate the complex interactions and feed-backs occurring within a soil profile in interaction with climate and human activities. We present here a component-based modelling platform named "VSoil", that aims at designing, developing, implementing and coupling numerical representation of biogeochemical and physical processes in soil, from the aggregate to the profile scales. The platform consists of four softwares, i) Vsoil_Processes dedicated to the conceptual description of processes and of their inputs and outputs, ii) Vsoil_Modules devoted to the development of numerical representation of elementary processes as modules, iii) Vsoil_Models which permits the coupling of modules to create models, iv) Vsoil_Player for the run of the model and the primary analysis of results. The platform is designed to be a collaborative tool, helping scientists to share not only their models, but also the scientific knowledge on which the models are built. The platform is based on the idea that processes of any kind can be described and characterized by their inputs (state variables required) and their outputs. The links between the processes are automatically detected by the platform softwares. For any process, several numerical representations (modules) can be developed and made available to platform users. When developing modules, the platform takes care of many aspects of the development task so that the user can focus on numerical calculations. Fortran2008 and C++ are the supported languages and existing codes can be easily incorporated into platform modules. Building a model from available modules simply requires selecting the processes being accounted for and for each process a module

Performance Analysis and Scaling Behavior of the Terrestrial Systems Modeling Platform TerrSysMP in Large-Scale Supercomputing Environments

NASA Astrophysics Data System (ADS)

Kollet, S. J.; Goergen, K.; Gasper, F.; Shresta, P.; Sulis, M.; Rihani, J.; Simmer, C.; Vereecken, H.

2013-12-01

In studies of the terrestrial hydrologic, energy and biogeochemical cycles, integrated multi-physics simulation platforms take a central role in characterizing non-linear interactions, variances and uncertainties of system states and fluxes in reciprocity with observations. Recently developed integrated simulation platforms attempt to honor the complexity of the terrestrial system across multiple time and space scales from the deeper subsurface including groundwater dynamics into the atmosphere. Technically, this requires the coupling of atmospheric, land surface, and subsurface-surface flow models in supercomputing environments, while ensuring a high-degree of efficiency in the utilization of e.g., standard Linux clusters and massively parallel resources. A systematic performance analysis including profiling and tracing in such an application is crucial in the understanding of the runtime behavior, to identify optimum model settings, and is an efficient way to distinguish potential parallel deficiencies. On sophisticated leadership-class supercomputers, such as the 28-rack 5.9 petaFLOP IBM Blue Gene/Q 'JUQUEEN' of the Jülich Supercomputing Centre (JSC), this is a challenging task, but even more so important, when complex coupled component models are to be analysed. Here we want to present our experience from coupling, application tuning (e.g. 5-times speedup through compiler optimizations), parallel scaling and performance monitoring of the parallel Terrestrial Systems Modeling Platform TerrSysMP. The modeling platform consists of the weather prediction system COSMO of the German Weather Service; the Community Land Model, CLM of NCAR; and the variably saturated surface-subsurface flow code ParFlow. The model system relies on the Multiple Program Multiple Data (MPMD) execution model where the external Ocean-Atmosphere-Sea-Ice-Soil coupler (OASIS3) links the component models. TerrSysMP has been instrumented with the performance analysis tool Scalasca and analyzed

Reprint of: Simulation Platform: a cloud-based online simulation environment.

PubMed

Yamazaki, Tadashi; Ikeno, Hidetoshi; Okumura, Yoshihiro; Satoh, Shunji; Kamiyama, Yoshimi; Hirata, Yutaka; Inagaki, Keiichiro; Ishihara, Akito; Kannon, Takayuki; Usui, Shiro

2011-11-01

For multi-scale and multi-modal neural modeling, it is needed to handle multiple neural models described at different levels seamlessly. Database technology will become more important for these studies, specifically for downloading and handling the neural models seamlessly and effortlessly. To date, conventional neuroinformatics databases have solely been designed to archive model files, but the databases should provide a chance for users to validate the models before downloading them. In this paper, we report our on-going project to develop a cloud-based web service for online simulation called "Simulation Platform". Simulation Platform is a cloud of virtual machines running GNU/Linux. On a virtual machine, various software including developer tools such as compilers and libraries, popular neural simulators such as GENESIS, NEURON and NEST, and scientific software such as Gnuplot, R and Octave, are pre-installed. When a user posts a request, a virtual machine is assigned to the user, and the simulation starts on that machine. The user remotely accesses to the machine through a web browser and carries out the simulation, without the need to install any software but a web browser on the user's own computer. Therefore, Simulation Platform is expected to eliminate impediments to handle multiple neural models that require multiple software. Copyright © 2011 Elsevier Ltd. All rights reserved.

A novel medical image data-based multi-physics simulation platform for computational life sciences.

PubMed

Neufeld, Esra; Szczerba, Dominik; Chavannes, Nicolas; Kuster, Niels

2013-04-06

Simulating and modelling complex biological systems in computational life sciences requires specialized software tools that can perform medical image data-based modelling, jointly visualize the data and computational results, and handle large, complex, realistic and often noisy anatomical models. The required novel solvers must provide the power to model the physics, biology and physiology of living tissue within the full complexity of the human anatomy (e.g. neuronal activity, perfusion and ultrasound propagation). A multi-physics simulation platform satisfying these requirements has been developed for applications including device development and optimization, safety assessment, basic research, and treatment planning. This simulation platform consists of detailed, parametrized anatomical models, a segmentation and meshing tool, a wide range of solvers and optimizers, a framework for the rapid development of specialized and parallelized finite element method solvers, a visualization toolkit-based visualization engine, a Python scripting interface for customized applications, a coupling framework, and more. Core components are cross-platform compatible and use open formats. Several examples of applications are presented: hyperthermia cancer treatment planning, tumour growth modelling, evaluating the magneto-haemodynamic effect as a biomarker and physics-based morphing of anatomical models.

Capturing Micro-topography of an Arctic Tundra Landscape through Digital Elevation Models (DEMs) Acquired from Various Remote Sensing Platforms

NASA Astrophysics Data System (ADS)

Vargas, S. A., Jr.; Tweedie, C. E.; Oberbauer, S. F.

2013-12-01

The need to improve the spatial and temporal scaling and extrapolation of plot level measurements of ecosystem structure and function to the landscape level has been identified as a persistent research challenge in the arctic terrestrial sciences. Although there has been a range of advances in remote sensing capabilities on satellite, fixed wing, helicopter and unmanned aerial vehicle platforms over the past decade, these present costly, logistically challenging (especially in the Arctic), technically demanding solutions for applications in an arctic environment. Here, we present a relatively low cost alternative to these platforms that uses kite aerial photography (KAP). Specifically, we demonstrate how digital elevation models (DEMs) were derived from this system for a coastal arctic landscape near Barrow, Alaska. DEMs of this area acquired from other remote sensing platforms such as Terrestrial Laser Scanning (TLS), Airborne Laser Scanning, and satellite imagery were also used in this study to determine accuracy and validity of results. DEMs interpolated using the KAP system were comparable to DEMs derived from the other platforms. For remotely sensing acre to kilometer square areas of interest, KAP has proven to be a low cost solution from which derived products that interface ground and satellite platforms can be developed by users with access to low-tech solutions and a limited knowledge of remote sensing.

USGS tethered ACP platforms: New design means more safety and accuracy

USGS Publications Warehouse

Morlock, S.E.; Stewart, J.A.; Rehmel, M.S.

2004-01-01

The US Geological Survey has developed an innovative tethered platform that supports an Acoustic Current Profiler (ACP) in making stream-flow measurements (use of the term ACP in this article refers to a class of instruments and not a specific brand name or model). The tethered platform reduces the hazards involved in conventional methods of stream-flow measurement. The use of the platform reduces or eliminates time spent by personnel in streams and boats or on bridges and cableway and stream-flow measurement accuracy is increased.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lowers the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, into High Bay 3 of the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. The C platform will be installed on the north side of High Bay 3. In view below are several of the previously installed levels of platforms. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Daily Reservoir Inflow Forecasting using Deep Learning with Downscaled Multi-General Circulation Models (GCMs) Platform

NASA Astrophysics Data System (ADS)

Li, D.; Fang, N. Z.

2017-12-01

Dallas-Fort Worth Metroplex (DFW) has a population of over 7 million depending on many water supply reservoirs. The reservoir inflow plays a vital role in water supply decision making process and long-term strategic planning for the region. This paper demonstrates a method of utilizing deep learning algorithms and multi-general circulation model (GCM) platform to forecast reservoir inflow for three reservoirs within the DFW: Eagle Mountain Lake, Lake Benbrook and Lake Arlington. Ensemble empirical mode decomposition was firstly employed to extract the features, which were then represented by the deep belief networks (DBNs). The first 75 years of the historical data (1940 -2015) were used to train the model, while the last 2 years of the data (2016-2017) were used for the model validation. The weights of each DBN gained from the training process were then applied to establish a neural network (NN) that was able to forecast reservoir inflow. Feature predictors used for the forecasting model were generated from weather forecast results of the downscaled multi-GCM platform for the North Texas region. By comparing root mean square error (RMSE) and mean bias error (MBE) with the observed data, the authors found that the deep learning with downscaled multi-GCM platform is an effective approach in the reservoir inflow forecasting.

A holistic approach to SIM platform and its application to early-warning satellite system

NASA Astrophysics Data System (ADS)

Sun, Fuyu; Zhou, Jianping; Xu, Zheyao

2018-01-01

This study proposes a new simulation platform named Simulation Integrated Management (SIM) for the analysis of parallel and distributed systems. The platform eases the process of designing and testing both applications and architectures. The main characteristics of SIM are flexibility, scalability, and expandability. To improve the efficiency of project development, new models of early-warning satellite system were designed based on the SIM platform. Finally, through a series of experiments, the correctness of SIM platform and the aforementioned early-warning satellite models was validated, and the systematical analyses for the orbital determination precision of the ballistic missile during its entire flight process were presented, as well as the deviation of the launch/landing point. Furthermore, the causes of deviation and prevention methods will be fully explained. The simulation platform and the models will lay the foundations for further validations of autonomy technology in space attack-defense architecture research.

Design of a dynamic test platform for autonomous robot vision systems

NASA Technical Reports Server (NTRS)

Rich, G. C.

1980-01-01

The concept and design of a dynamic test platform for development and evluation of a robot vision system is discussed. The platform is to serve as a diagnostic and developmental tool for future work with the RPI Mars Rover's multi laser/multi detector vision system. The platform allows testing of the vision system while its attitude is varied, statically or periodically. The vision system is mounted on the test platform. It can then be subjected to a wide variety of simulated can thus be examined in a controlled, quantitative fashion. Defining and modeling Rover motions and designing the platform to emulate these motions are also discussed. Individual aspects of the design process are treated separately, as structural, driving linkages, and motors and transmissions.

Tethys: A Platform for Water Resources Modeling and Decision Support Apps

NASA Astrophysics Data System (ADS)

Swain, N. R.; Christensen, S. D.; Jones, N.; Nelson, E. J.

2014-12-01

Cloud-based applications or apps are a promising medium through which water resources models and data can be conveyed in a user-friendly environment—making them more accessible to decision-makers and stakeholders. In the context of this work, a water resources web app is a web application that exposes limited modeling functionality for a scenario exploration activity in a structured workflow (e.g.: land use change runoff analysis, snowmelt runoff prediction, and flood potential analysis). The technical expertise required to develop water resources web apps can be a barrier to many potential developers of water resources apps. One challenge that developers face is in providing spatial storage, analysis, and visualization for the spatial data that is inherent to water resources models. The software projects that provide this functionality are non-standard to web development and there are a large number of free and open source software (FOSS) projects to choose from. In addition, it is often required to synthesize several software projects to provide all of the needed functionality. Another challenge for the developer will be orchestrating the use of several software components. Consequently, the initial software development investment required to deploy an effective water resources cloud-based application can be substantial. The Tethys Platform has been developed to lower the technical barrier and minimize the initial development investment that prohibits many scientists and engineers from making use of the web app medium. Tethys synthesizes several software projects including PostGIS for spatial storage, 52°North WPS for spatial analysis, GeoServer for spatial publishing, Google Earth™, Google Maps™ and OpenLayers for spatial visualization, and Highcharts for plotting tabular data. The software selection came after a literature review of software projects being used to create existing earth sciences web apps. All of the software is linked via a Python

Spacecraft Bus and Platform Technology Development under the NASA ISPT Program

NASA Technical Reports Server (NTRS)

Anderson, David J.; Munk, Michelle M.; Pencil, Eric; Dankanich, John; Glaab, Louis; Peterson, Todd

2013-01-01

The In-Space Propulsion Technology (ISPT) program is developing spacecraft bus and platform technologies that will enable or enhance NASA robotic science missions. The ISPT program is currently developing technology in four areas that include Propulsion System Technologies (electric and chemical), Entry Vehicle Technologies (aerocapture and Earth entry vehicles), Spacecraft Bus and Sample Return Propulsion Technologies (components and ascent vehicles), and Systems/Mission Analysis. Three technologies are ready for near-term flight infusion: 1) the high-temperature Advanced Material Bipropellant Rocket (AMBR) engine providing higher performance; 2) NASA s Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6-7 kW throttle-able gridded ion system; and 3) Aerocapture technology development with investments in a family of thermal protection system (TPS) materials and structures; guidance, navigation, and control (GN&C) models of blunt-body rigid aeroshells; and aerothermal effect models. Two component technologies being developed with flight infusion in mind are the Advanced Xenon Flow Control System, and ultra-lightweight propellant tank technologies. Future direction for ISPT are technologies that relate to sample return missions and other spacecraft bus technology needs like: 1) Mars Ascent Vehicles (MAV); 2) multi-mission technologies for Earth Entry Vehicles (MMEEV) for sample return missions; and 3) electric propulsion for sample return and low cost missions. These technologies are more vehicle and mission-focused, and present a different set of technology development and infusion steps beyond those previously implemented. The Systems/Mission Analysis area is focused on developing tools and assessing the application of propulsion and spacecraft bus technologies to a wide variety of mission concepts. These in-space propulsion technologies are applicable, and potentially enabling for future NASA Discovery, New Frontiers, and sample return missions

Spacecraft Bus and Platform Technology Development under the NASA ISPT Program

NASA Technical Reports Server (NTRS)

Anderson, David J.; Munk, Michelle M.; Pencil, Eric J.; Dankanich, John W.; Glaab, Louis J.; Peterson, Todd T.

2013-01-01

The In-Space Propulsion Technology (ISPT) program is developing spacecraft bus and platform technologies that will enable or enhance NASA robotic science missions. The ISPT program is currently developing technology in four areas that include Propulsion System Technologies (electric and chemical), Entry Vehicle Technologies (aerocapture and Earth entry vehicles), Spacecraft Bus and Sample Return Propulsion Technologies (components and ascent vehicles), and Systems/Mission Analysis. Three technologies are ready for near-term flight infusion: 1) the high-temperature Advanced Material Bipropellant Rocket (AMBR) engine providing higher performance 2) NASAs Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6-7 kW throttle-able gridded ion system and 3) Aerocapture technology development with investments in a family of thermal protection system (TPS) materials and structures guidance, navigation, and control (GN&C) models of blunt-body rigid aeroshells and aerothermal effect models. Two component technologies being developed with flight infusion in mind are the Advanced Xenon Flow Control System, and ultra-lightweight propellant tank technologies. Future direction for ISPT are technologies that relate to sample return missions and other spacecraft bus technology needs like: 1) Mars Ascent Vehicles (MAV) 2) multi-mission technologies for Earth Entry Vehicles (MMEEV) for sample return missions and 3) electric propulsion for sample return and low cost missions. These technologies are more vehicle and mission-focused, and present a different set of technology development and infusion steps beyond those previously implemented. The Systems/Mission Analysis area is focused on developing tools and assessing the application of propulsion and spacecraft bus technologies to a wide variety of mission concepts. These in-space propulsion technologies are applicable, and potentially enabling for future NASA Discovery, New Frontiers, and sample return missions currently

Design and development of a microfluidic platform for use with colorimetric gold nanoprobe assays

NASA Astrophysics Data System (ADS)

Bernacka-Wojcik, Iwona

Due to the importance and wide applications of the DNA analysis, there is a need to make genetic analysis more available and more affordable. As such, the aim of this PhD thesis is to optimize a colorimetric DNA biosensor based on gold nanoprobes developed in CEMOP by reducing its price and the needed volume of solution without compromising the device sensitivity and reliability, towards the point of care use. Firstly, the price of the biosensor was decreased by replacing the silicon photodetector by a low cost, solution processed TiO2 photodetector. To further reduce the photodetector price, a novel fabrication method was developed: a cost-effective inkjet printing technology that enabled to increase TiO2 surface area. Secondly, the DNA biosensor was optimized by means of microfluidics that offer advantages of miniaturization, much lower sample/reagents consumption, enhanced system performance and functionality by integrating different components. In the developed microfluidic platform, the optical path length was extended by detecting along the channel and the light was transmitted by optical fibres enabling to guide the light very close to the analysed solution. Microfluidic chip of high aspect ratio ( 13), smooth and nearly vertical sidewalls was fabricated in PDMS using a SU-8 mould for patterning. The platform coupled to the gold nanoprobe assay enabled detection of Mycobacterium tuberculosis using 3 mul on DNA solution, i.e. 20 times less than in the previous state-of-the-art. Subsequently, the bio-microfluidic platform was optimized in terms of cost, electrical signal processing and sensitivity to colour variation, yielding 160% improvement of colorimetric AuNPs analysis. Planar microlenses were incorporated to converge light into the sample and then to the output fibre core increasing 6 times the signal-to-losses ratio. The optimized platform enabled detection of single nucleotide polymorphism related with obesity risk (FTO) using target DNA concentration

Development and Testing of a Mobile Platform for Tank Remediation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nance, T.A.

2001-01-16

tethers as the mobile platform moves the spray system across the tank floor. Both the crawler and spray systems are designed to be retrievable. Development of the tank cleaning system was evaluated using a performance test program. The tests evaluated the spray system dynamics, the crawler's fit through the riser, the crawler landing in mocked up tank with simulant, the crawler's traction, and the crawler and spray system mating. Initial testing verified the crawler platform was compatible with the dynamics produced by the spray system. The riser fit test confirmed that a dedicated riser is required for deployment of the crawler and the spray system. The crawler traction test defined the capabilities of the crawler at different levels of simulant. Deployment testing through a mockup riser verified the basic system processes. Finally, testing of the complete system in a full-scale mockup with sludge simulant was performed to evaluate the tank cleaning ability of the crawler. This paper describes th e tank conditions, the tank closure process, the development of the crawler and spray system, and the testing program and results used to evaluate the mobile platform and spray system.« less

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be installed on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

COBALT: Development of a Platform to Flight Test Lander GN&C Technologies on Suborbital Rockets

NASA Technical Reports Server (NTRS)

Carson, John M., III; Seubert, Carl R.; Amzajerdian, Farzin; Bergh, Chuck; Kourchians, Ara; Restrepo, Carolina I.; Villapando, Carlos Y.; O'Neal, Travis V.; Robertson, Edward A.; Pierrottet, Diego;

Two complementary personal medication management applications developed on a common platform: case report.

PubMed

Ross, Stephen E; Johnson, Kevin B; Siek, Katie A; Gordon, Jeffry S; Khan, Danish U; Haverhals, Leah M

2011-07-12

Adverse drug events are a major safety issue in ambulatory care. Improving medication self-management could reduce these adverse events. Researchers have developed medication applications for tethered personal health records (PHRs), but little has been reported about medication applications for interoperable PHRs. Our objective was to develop two complementary personal health applications on a common PHR platform: one to assist children with complex health needs (MyMediHealth), and one to assist older adults in care transitions (Colorado Care Tablet). The applications were developed using a user-centered design approach. The two applications shared a common PHR platform based on a service-oriented architecture. MyMediHealth employed Web and mobile phone user interfaces. Colorado Care Tablet employed a Web interface customized for a tablet PC. We created complementary medication management applications tailored to the needs of distinctly different user groups using common components. Challenges were addressed in multiple areas, including how to encode medication identities, how to incorporate knowledge bases for medication images and consumer health information, how to include supplementary dosing information, how to simplify user interfaces for older adults, and how to support mobile devices for children. These prototypes demonstrate the utility of abstracting PHR data and services (the PHR platform) from applications that can be tailored to meet the needs of diverse patients. Based on the challenges we faced, we provide recommendations on the structure of publicly available knowledge resources and the use of mobile messaging systems for PHR applications.

Vaccine platform recombinant measles virus.

PubMed

Mühlebach, Michael D

2017-10-01

The classic development of vaccines is lengthy, tedious, and may not necessarily be successful as demonstrated by the case of HIV. This is especially a problem for emerging pathogens that are newly introduced into the human population and carry the inherent risk of pandemic spread in a naïve population. For such situations, a considerable number of different platform technologies are under development. These are also under development for pathogens, where directly derived vaccines are regarded as too complicated or even dangerous due to the induction of inefficient or unwanted immune responses causing considerable side-effects as for dengue virus. Among platform technologies are plasmid-based DNA vaccines, RNA replicons, single-round infectious vector particles, or replicating vaccine-based vectors encoding (a) critical antigen(s) of the target pathogens. Among the latter, recombinant measles viruses derived from vaccine strains have been tested. Measles vaccines are among the most effective and safest life-attenuated vaccines known. Therefore, the development of Schwarz-, Moraten-, or AIK-C-strain derived recombinant vaccines against a wide range of mostly viral, but also bacterial pathogens was quite straightforward. These vaccines generally induce powerful humoral and cellular immune responses in appropriate animal models, i.e., transgenic mice or non-human primates. Also in the recent first clinical phase I trial, the results have been quite encouraging. The trial indicated the expected safety and efficacy also in human patients, interestingly independent from the level of prevalent anti-measles immunity before the trial. Thereby, recombinant measles vaccines expressing additional antigens are a promising platform for future vaccines.

The Role of Bed Roughness in Wave Transformation Across Sloping Rock Shore Platforms

NASA Astrophysics Data System (ADS)

Poate, Tim; Masselink, Gerd; Austin, Martin J.; Dickson, Mark; McCall, Robert

2018-01-01

We present for the first time observations and model simulations of wave transformation across sloping (Type A) rock shore platforms. Pressure measurements of the water surface elevation using up to 15 sensors across five rock platforms with contrasting roughness, gradient, and wave climate represent the most extensive collected, both in terms of the range of environmental conditions, and the temporal and spatial resolution. Platforms are shown to dissipate both incident and infragravity wave energy as skewness and asymmetry develop and, in line with previous studies, surf zone wave heights are saturated and strongly tidally modulated. Overall, the observed properties of the waves and formulations derived from sandy beaches do not highlight any systematic interplatform variation, in spite of significant differences in platform roughness, suggesting that friction can be neglected when studying short wave transformation. Optimization of a numerical wave transformation model shows that the wave breaker criterion falls between the range of values reported for flat sandy beaches and those of steep coral fore reefs. However, the optimized drag coefficient shows significant scatter for the roughest sites and an alternative empirical drag model, based on the platform roughness, does not improve model performance. Thus, model results indicate that the parameterization of frictional drag using the bottom roughness length-scale may be inappropriate for the roughest platforms. Based on these results, we examine the balance of wave breaking to frictional dissipation for rock platforms and find that friction is only significant for very rough, flat platforms during small wave conditions outside the surf zone.

Design of the smart scenic spot service platform

NASA Astrophysics Data System (ADS)

Yin, Min; Wang, Shi-tai

2015-12-01

With the deepening of the smart city construction, the model "smart+" is rapidly developing. Guilin, the international tourism metropolis fast constructing need smart tourism technology support. This paper studied the smart scenic spot service object and its requirements. And then constructed the smart service platform of the scenic spot application of 3S technology (Geographic Information System (GIS), Remote Sensing (RS) and Global Navigation Satellite System (GNSS)) and the Internet of things, cloud computing. Based on Guilin Seven-star Park scenic area as an object, this paper designed the Seven-star smart scenic spot service platform framework. The application of this platform will improve the tourists' visiting experience, make the tourism management more scientifically and standardly, increase tourism enterprises operating earnings.

Making Spatial Statistics Service Accessible On Cloud Platform

NASA Astrophysics Data System (ADS)

Mu, X.; Wu, J.; Li, T.; Zhong, Y.; Gao, X.

2014-04-01

Web service can bring together applications running on diverse platforms, users can access and share various data, information and models more effectively and conveniently from certain web service platform. Cloud computing emerges as a paradigm of Internet computing in which dynamical, scalable and often virtualized resources are provided as services. With the rampant growth of massive data and restriction of net, traditional web services platforms have some prominent problems existing in development such as calculation efficiency, maintenance cost and data security. In this paper, we offer a spatial statistics service based on Microsoft cloud. An experiment was carried out to evaluate the availability and efficiency of this service. The results show that this spatial statistics service is accessible for the public conveniently with high processing efficiency.

Development of In Vitro Co-Culture Model in Anti-Cancer Drug Development Cascade.

PubMed

Xu, Ruiling; Richards, Frances M

2017-01-01

Tumour microenvironment is recognized as a major determinant of intrinsic resistance to anticancer therapies. In solid tumour types, such as breast cancer, lung cancer and pancreatic cancer, stromal components provide a fibrotic niche, which promotes stemness, EMT, chemo- and radioresistance of tumour. However, this microenvironment is not recapitulated in the conventional cell monoculture or xenografts, hence these in vitro and in vivo preclinical models are unlikely to be predictive of clinical response; which might attribute to the poor predictively of these preclinical drug-screening models. In this review, we summarized recently developed co-culture platforms in various tumour types that incorporate different stromal cell types and/or extracellular matrix (ECM), in the context of investigating potential mechanisms of stroma-mediated chemoresistance and evaluating novel agents and combinations. Some of these platforms will have great utility in the assessment of novel drug combinations and mechanistic understanding of the tumor-stroma interactions. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Remotely Delivered Exercise-Based Cardiac Rehabilitation: Design and Content Development of a Novel mHealth Platform.

PubMed

Rawstorn, Jonathan C; Gant, Nicholas; Meads, Andrew; Warren, Ian; Maddison, Ralph

2016-06-24

Participation in traditional center-based cardiac rehabilitation exercise programs (exCR) is limited by accessibility barriers. Mobile health (mHealth) technologies can overcome these barriers while preserving critical attributes of center-based exCR monitoring and coaching, but these opportunities have not yet been capitalized on. We aimed to design and develop an evidence- and theory-based mHealth platform for remote delivery of exCR to any geographical location. An iterative process was used to design and develop an evidence- and theory-based mHealth platform (REMOTE-CR) that provides real-time remote exercise monitoring and coaching, behavior change education, and social support. The REMOTE-CR platform comprises a commercially available smartphone and wearable sensor, custom smartphone and Web-based applications (apps), and a custom middleware. The platform allows exCR specialists to monitor patients' exercise and provide individualized coaching in real-time, from almost any location, and provide behavior change education and social support. Intervention content incorporates Social Cognitive Theory, Self-determination Theory, and a taxonomy of behavior change techniques. Exercise components are based on guidelines for clinical exercise prescription. The REMOTE-CR platform extends the capabilities of previous telehealth exCR platforms and narrows the gap between existing center- and home-based exCR services. REMOTE-CR can complement center-based exCR by providing an alternative option for patients whose needs are not being met. Remotely monitored exCR may be more cost-effective than establishing additional center-based programs. The effectiveness and acceptability of REMOTE-CR are now being evaluated in a noninferiority randomized controlled trial.

Effects of Social Network Exposure on Nutritional Learning: Development of an Online Educational Platform.

PubMed

Dagan, Noa; Beskin, Daniel; Brezis, Mayer; Reis, Ben Y

2015-10-05

Social networking sites (SNSs) such as Facebook have the potential to enhance online public health interventions, in part, as they provide social exposure and reinforcement. The objective of the study was to evaluate whether social exposure provided by SNSs enhances the effects of online public health interventions. As a sample intervention, we developed Food Hero, an online platform for nutritional education in which players feed a virtual character according to their own nutritional needs and complete a set of virtual sport challenges. The platform was developed in 2 versions: a "private version" in which a user can see only his or her own score, and a "social version" in which a user can see other players' scores, including preexisting Facebook friends. We assessed changes in participants' nutritional knowledge using 4 quiz scores and 3 menu-assembly scores. Monitoring feeding and exercising attempts assessed engagement with the platform. The 2 versions of the platform were randomly assigned between a study group (30 members receiving the social version) and a control group (33 members, private version). The study group's performance on the quizzes gradually increased over time, relative to that of the control group, becoming significantly higher by the fourth quiz (P=.02). Furthermore, the study group's menu-assembly scores improved over time compared to the first score, whereas the control group's performance deteriorated. Study group members spent an average of 3:40 minutes assembling each menu compared to 2:50 minutes in the control group, and performed an average of 1.58 daily sport challenges, compared to 1.21 in the control group (P=.03). This work focused on isolating the SNSs' social effects in order to help guide future online interventions. Our results indicate that the social exposure provided by SNSs is associated with increased engagement and learning in an online nutritional educational platform.

Supporting Collaborative Model and Data Service Development and Deployment with DevOps

NASA Astrophysics Data System (ADS)

David, O.

2016-12-01

Adopting DevOps practices for model service development and deployment enables a community to engage in service-oriented modeling and data management. The Cloud Services Integration Platform (CSIP) developed the last 5 years at Colorado State University provides for collaborative integration of environmental models into scalable model and data services as a micro-services platform with API and deployment infrastructure. Originally developed to support USDA natural resource applications, it proved suitable for a wider range of applications in the environmental modeling domain. While extending its scope and visibility it became apparent community integration and adequate work flow support through the full model development and application cycle drove successful outcomes.DevOps provide best practices, tools, and organizational structures to optimize the transition from model service development to deployment by minimizing the (i) operational burden and (ii) turnaround time for modelers. We have developed and implemented a methodology to fully automate a suite of applications for application lifecycle management, version control, continuous integration, container management, and container scaling to enable model and data service developers in various institutions to collaboratively build, run, deploy, test, and scale services within minutes.To date more than 160 model and data services are available for applications in hydrology (PRMS, Hydrotools, CFA, ESP), water and wind erosion prediction (WEPP, WEPS, RUSLE2), soil quality trends (SCI, STIR), water quality analysis (SWAT-CP, WQM, CFA, AgES-W), stream degradation assessment (SWAT-DEG), hydraulics (cross-section), and grazing management (GRAS). In addition, supporting data services include soil (SSURGO), ecological site (ESIS), climate (CLIGEN, WINDGEN), land management and crop rotations (LMOD), and pesticides (WQM), developed using this workflow automation and decentralized governance.

The Generation Challenge Programme Platform: Semantic Standards and Workbench for Crop Science

PubMed Central

Bruskiewich, Richard; Senger, Martin; Davenport, Guy; Ruiz, Manuel; Rouard, Mathieu; Hazekamp, Tom; Takeya, Masaru; Doi, Koji; Satoh, Kouji; Costa, Marcos; Simon, Reinhard; Balaji, Jayashree; Akintunde, Akinnola; Mauleon, Ramil; Wanchana, Samart; Shah, Trushar; Anacleto, Mylah; Portugal, Arllet; Ulat, Victor Jun; Thongjuea, Supat; Braak, Kyle; Ritter, Sebastian; Dereeper, Alexis; Skofic, Milko; Rojas, Edwin; Martins, Natalia; Pappas, Georgios; Alamban, Ryan; Almodiel, Roque; Barboza, Lord Hendrix; Detras, Jeffrey; Manansala, Kevin; Mendoza, Michael Jonathan; Morales, Jeffrey; Peralta, Barry; Valerio, Rowena; Zhang, Yi; Gregorio, Sergio; Hermocilla, Joseph; Echavez, Michael; Yap, Jan Michael; Farmer, Andrew; Schiltz, Gary; Lee, Jennifer; Casstevens, Terry; Jaiswal, Pankaj; Meintjes, Ayton; Wilkinson, Mark; Good, Benjamin; Wagner, James; Morris, Jane; Marshall, David; Collins, Anthony; Kikuchi, Shoshi; Metz, Thomas; McLaren, Graham; van Hintum, Theo

2008-01-01

The Generation Challenge programme (GCP) is a global crop research consortium directed toward crop improvement through the application of comparative biology and genetic resources characterization to plant breeding. A key consortium research activity is the development of a GCP crop bioinformatics platform to support GCP research. This platform includes the following: (i) shared, public platform-independent domain models, ontology, and data formats to enable interoperability of data and analysis flows within the platform; (ii) web service and registry technologies to identify, share, and integrate information across diverse, globally dispersed data sources, as well as to access high-performance computational (HPC) facilities for computationally intensive, high-throughput analyses of project data; (iii) platform-specific middleware reference implementations of the domain model integrating a suite of public (largely open-access/-source) databases and software tools into a workbench to facilitate biodiversity analysis, comparative analysis of crop genomic data, and plant breeding decision making. PMID:18483570

A microfabricated platform to form three-dimensional toroidal multicellular aggregate.

PubMed

Masuda, Taisuke; Takei, Natsuki; Nakano, Takuma; Anada, Takahisa; Suzuki, Osamu; Arai, Fumihito

2012-12-01

Techniques that allow cells to self-assemble into three-dimensional (3D) spheroid microtissues provide powerful in vitro models that are becoming increasingly popular in fields such as stem cell research, tissue engineering, and cancer biology. Appropriate simulation of the 3D environment in which tissues normally develop and function is crucial for the engineering of in vitro models that can be used for the formation of complex tissues. We have developed a unique multicellular aggregate formation platform that utilizes a maskless gray-scale photolithography. The cellular aggregate formed using this platform has a toroidal-like geometry and includes a micro lumen that facilitates the supply of oxygen and growth factors and the expulsion of waste products. As a result, this platform was capable of rapidly producing hundreds of multicellular aggregates at a time, and of regulating the diameter of aggregates with complex design. These toroidal multicellular aggregates can grow as long-term culture. In addition, the micro lumen can be used as a continuous channel and for the insertion of a vascular system or a nerve system into the assembled tissue. These platform characteristics highlight its potential to be used in a wide variety of applications, e.g. as a bioactuator, as a micro-machine component or in drug screening and tissue engineering.

Design Strategy for a Formally Verified Reliable Computing Platform

NASA Technical Reports Server (NTRS)

Butler, Ricky W.; Caldwell, James L.; DiVito, Ben L.

1991-01-01

This paper presents a high-level design for a reliable computing platform for real-time control applications. The design tradeoffs and analyses related to the development of a formally verified reliable computing platform are discussed. The design strategy advocated in this paper requires the use of techniques that can be completely characterized mathematically as opposed to more powerful or more flexible algorithms whose performance properties can only be analyzed by simulation and testing. The need for accurate reliability models that can be related to the behavior models is also stressed. Tradeoffs between reliability and voting complexity are explored. In particular, the transient recovery properties of the system are found to be fundamental to both the reliability analysis as well as the "correctness" models.

Development of fast wireless detection system for fixed offshore platform

NASA Astrophysics Data System (ADS)

Li, Zhigang; Yu, Yan; Jiao, Dong; Wang, Jie; Li, Zhirui; Ou, Jinping

2011-04-01

Offshore platforms' security is concerned since in 1950s and 1960s, and in the early 1980s some important specifications and standards are built, and all these provide technical basis of fixed platform design, construction, installation and evaluation. With the condition that more and more platforms are in serving over age, the research about the evaluation and detection technology of offshore platform has been a hotspot, especially underwater detection, and assessment method based on the finite element calculation. For fixed platform structure detection, conventional NDT methods, such as eddy current, magnetic powder, permeate, X-ray and ultrasonic, etc, are generally used. These techniques are more mature, intuitive, but underwater detection needs underwater robot, the necessary supporting tools of auxiliary equipment, and trained professional team, thus resources and cost used are considerable, installation time of test equipment is long. This project presents a new kind of fast wireless detection and damage diagnosis system for fixed offshore platform using wireless sensor networks, that is, wireless sensor nodes can be put quickly on the offshore platform, detect offshore platform structure global status by wireless communication, and then make diagnosis. This system is operated simply, suitable for offshore platform integrity states rapid assessment. The designed system consists in intelligence acquisition equipment and 8 wireless collection nodes, the whole system has 64 collection channels, namely every wireless collection node has eight 16-bit accuracy of A/D channels. Wireless collection node, integrated with vibration sensing unit, embedded low-power micro-processing unit, wireless transceiver unit, large-capacity power unit, and GPS time synchronization unit, can finish the functions such as vibration data collection, initial analysis, data storage, data wireless transmission. Intelligence acquisition equipment, integrated with high

Predictive modelling for startup and investor relationship based on crowdfunding platform data

NASA Astrophysics Data System (ADS)

Alamsyah, Andry; Buono Asto Nugroho, Tri

2018-03-01

Crowdfunding platform is a place where startup shows off publicly their idea for the purpose to get their project funded. Crowdfunding platform such as Kickstarter are becoming popular today, it provides the efficient way for startup to get funded without liabilities, it also provides variety project category that can be participated. There is an available safety procedure to ensure achievable low-risk environment. The startup promoted project must accomplish their funded goal target. If they fail to reach the target, then there is no investment activity take place. It motivates startup to be more active to promote or disseminate their project idea and it also protect investor from losing money. The study objective is to predict the successfulness of proposed project and mapping investor trend using data mining framework. To achieve the objective, we proposed 3 models. First model is to predict whether a project is going to be successful or failed using K-Nearest Neighbour (KNN). Second model is to predict the number of successful project using Artificial Neural Network (ANN). Third model is to map the trend of investor in investing the project using K-Means clustering algorithm. KNN gives 99.04% model accuracy, while ANN best configuration gives 16-14-1 neuron layers and 0.2 learning rate, and K-Means gives 6 best separation clusters. The results of those models can help startup or investor to make decision regarding startup investment.

In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform.

PubMed

Katt, Moriah E; Placone, Amanda L; Wong, Andrew D; Xu, Zinnia S; Searson, Peter C

2016-01-01

In vitro tumor models have provided important tools for cancer research and serve as low-cost screening platforms for drug therapies; however, cancer recurrence remains largely unchecked due to metastasis, which is the cause of the majority of cancer-related deaths. The need for an improved understanding of the progression and treatment of cancer has pushed for increased accuracy and physiological relevance of in vitro tumor models. As a result, in vitro tumor models have concurrently increased in complexity and their output parameters further diversified, since these models have progressed beyond simple proliferation, invasion, and cytotoxicity screens and have begun recapitulating critical steps in the metastatic cascade, such as intravasation, extravasation, angiogenesis, matrix remodeling, and tumor cell dormancy. Advances in tumor cell biology, 3D cell culture, tissue engineering, biomaterials, microfabrication, and microfluidics have enabled rapid development of new in vitro tumor models that often incorporate multiple cell types, extracellular matrix materials, and spatial and temporal introduction of soluble factors. Other innovations include the incorporation of perfusable microvessels to simulate the tumor vasculature and model intravasation and extravasation. The drive toward precision medicine has increased interest in adapting in vitro tumor models for patient-specific therapies, clinical management, and assessment of metastatic potential. Here, we review the wide range of current in vitro tumor models and summarize their advantages, disadvantages, and suitability in modeling specific aspects of the metastatic cascade and drug treatment.

In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform

PubMed Central

Katt, Moriah E.; Placone, Amanda L.; Wong, Andrew D.; Xu, Zinnia S.; Searson, Peter C.

2016-01-01

In vitro tumor models have provided important tools for cancer research and serve as low-cost screening platforms for drug therapies; however, cancer recurrence remains largely unchecked due to metastasis, which is the cause of the majority of cancer-related deaths. The need for an improved understanding of the progression and treatment of cancer has pushed for increased accuracy and physiological relevance of in vitro tumor models. As a result, in vitro tumor models have concurrently increased in complexity and their output parameters further diversified, since these models have progressed beyond simple proliferation, invasion, and cytotoxicity screens and have begun recapitulating critical steps in the metastatic cascade, such as intravasation, extravasation, angiogenesis, matrix remodeling, and tumor cell dormancy. Advances in tumor cell biology, 3D cell culture, tissue engineering, biomaterials, microfabrication, and microfluidics have enabled rapid development of new in vitro tumor models that often incorporate multiple cell types, extracellular matrix materials, and spatial and temporal introduction of soluble factors. Other innovations include the incorporation of perfusable microvessels to simulate the tumor vasculature and model intravasation and extravasation. The drive toward precision medicine has increased interest in adapting in vitro tumor models for patient-specific therapies, clinical management, and assessment of metastatic potential. Here, we review the wide range of current in vitro tumor models and summarize their advantages, disadvantages, and suitability in modeling specific aspects of the metastatic cascade and drug treatment. PMID:26904541

Development of an ultra-sensitive Simoa assay to enable GDF11 detection: a comparison across bioanalytical platforms.

PubMed

Myzithras, Maria; Li, Hua; Bigwarfe, Tammy; Waltz, Erica; Gupta, Priyanka; Low, Sarah; Hayes, David B; MacDonnell, Scott; Ahlberg, Jennifer; Franti, Michael; Roberts, Simon

2016-03-01

Four bioanalytical platforms were evaluated to optimize sensitivity and enable detection of recombinant human GDF11 in biological matrices; ELISA, Meso Scale Discovery, Gyrolab xP Workstation and Simoa HD-1. Results & methodology: After completion of custom assay development, the single-molecule ELISA (Simoa) achieved the greatest sensitivity with a lower limit of quantitation of 0.1 ng/ml, an improvement of 100-fold over the next sensitive platform (MSD). This improvement was essential to enable detection of GDF11 in biological samples, and without the technology the sensitivity achieved on the other platforms would not have been sufficient. Other factors such as ease of use, cost, assay time and automation capability can also be considered when developing custom immunoassays, based on the requirements of the bioanalyst.

NBIC-Convergence as a Paradigm Platform of Sustainable Development

NASA Astrophysics Data System (ADS)

Dotsenko, Elena

2017-11-01

Today, the fastest rates of scientific and technological development are typical for the spheres of nano-systems and materials industry, information and communication systems, as well as spheres of direct human impact on environment - power industry, urbanization, and industrial infrastructure. Accelerate replacement of a human by machines and robots, the construction of megacities; the transportation of huge volumes of environmentally hazardous goods takes place against the background of intensive generation of knowledge, the transition of the results of fundamental research into specific production technologies. In this process, on the one hand, a fundamentally new format for technological restructuring of the world economy is being developed. On the other hand, a new platform for human-environment interaction is being formed, where both positive and negative environmental impacts will be determined by unstudied factors in the near future. The reason for this is in the forthcoming replacement of the technologies that are familiar to us, although dynamically developing, by fundamentally new - convergent. Entering the front line of technological development - NBIC-convergence - requires a new paradigm of sustainable development.

A gimbal platform stabilization for topographic applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michele, Mangiameli, E-mail: michele.mangiameli@dica.unict.it; Giuseppe, Mussumeci

2015-03-10

The aim of this work is the stabilization of a Gimbal platform for optical sensors acquisitions in topographic applications using mobile vehicles. The stabilization of the line of sight (LOS) consists in tracking the command velocity in presence of nonlinear noise due to the external environment. The hardware architecture is characterized by an Ardupilot platform that allows the control of both the mobile device and the Gimbal. Here we developed a new approach to stabilize the Gimbal platform, which is based on neural network. For the control system, we considered a plant that represents the transfer function of the servomore » system control model for an inertial stabilized Gimbal platform. The transductor used in the feed-back line control is characterized by the Rate Gyro transfer function installed onboard of Ardupilot. For the simulation and investigation of the system performance, we used the Simulink tool of Matlab. Results show that the hardware/software approach is efficient, reliable and cheap for direct photogrammetry, as well as for general purpose applications using mobile vehicles.« less

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be installed on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle of the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the north side of High Bay 3. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform C North Installation

NASA Image and Video Library

2016-11-10

A heavy-lift crane lifts the second half of the C-level work platforms, C north, for NASA’s Space Launch System (SLS) rocket, high up from the transfer aisle floor of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. The C platform will be moved into High Bay 3 for installation on the north wall. The C platforms are the eighth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Platform B North Installation

NASA Image and Video Library

2016-12-16

A construction worker solders a section of steel during the installation of the second half of the B-level work platforms, B north, for NASA's Space Launch System (SLS) rocket, in High Bay 3 in the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Construction workers will secure the large bolts that hold the platform in place on the north wall. The B platforms are the ninth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

PR-PR: cross-platform laboratory automation system.

PubMed

Linshiz, Gregory; Stawski, Nina; Goyal, Garima; Bi, Changhao; Poust, Sean; Sharma, Monica; Mutalik, Vivek; Keasling, Jay D; Hillson, Nathan J

2014-08-15

To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

SWATShare- A Platform for Collaborative Hydrology Research and Education with Cyber-enabled Sharing, Running and Visualization of SWAT Models

NASA Astrophysics Data System (ADS)

Rajib, M. A.; Merwade, V.; Song, C.; Zhao, L.; Kim, I. L.; Zhe, S.

2014-12-01

Setting up of any hydrologic model requires a large amount of efforts including compilation of all the data, creation of input files, calibration and validation. Given the amount of efforts involved, it is possible that models for a watershed get created multiple times by multiple groups or organizations to accomplish different research, educational or policy goals. To reduce the duplication of efforts and enable collaboration among different groups or organizations around an already existing hydrology model, a platform is needed where anyone can search for existing models, perform simple scenario analysis and visualize model results. The creator and users of a model on such a platform can then collaborate to accomplish new research or educational objectives. From this perspective, a prototype cyber-infrastructure (CI), called SWATShare, is developed for sharing, running and visualizing Soil Water Assessment Tool (SWAT) models in an interactive GIS-enabled web environment. Users can utilize SWATShare to publish or upload their own models, search and download existing SWAT models developed by others, run simulations including calibration using high performance resources provided by XSEDE and Cloud. Besides running and sharing, SWATShare hosts a novel spatio-temporal visualization system for SWAT model outputs. In temporal scale, the system creates time-series plots for all the hydrology and water quality variables available along the reach as well as in watershed-level. In spatial scale, the system can dynamically generate sub-basin level thematic maps for any variable at any user-defined date or date range; and thereby, allowing users to run animations or download the data for subsequent analyses. In addition to research, SWATShare can also be used within a classroom setting as an educational tool for modeling and comparing the hydrologic processes under different geographic and climatic settings. SWATShare is publicly available at https://www.water-hub.org/swatshare.

Connecting Artificial Brains to Robots in a Comprehensive Simulation Framework: The Neurorobotics Platform.

PubMed

Falotico, Egidio; Vannucci, Lorenzo; Ambrosano, Alessandro; Albanese, Ugo; Ulbrich, Stefan; Vasquez Tieck, Juan Camilo; Hinkel, Georg; Kaiser, Jacques; Peric, Igor; Denninger, Oliver; Cauli, Nino; Kirtay, Murat; Roennau, Arne; Klinker, Gudrun; Von Arnim, Axel; Guyot, Luc; Peppicelli, Daniel; Martínez-Cañada, Pablo; Ros, Eduardo; Maier, Patrick; Weber, Sandro; Huber, Manuel; Plecher, David; Röhrbein, Florian; Deser, Stefan; Roitberg, Alina; van der Smagt, Patrick; Dillman, Rüdiger; Levi, Paul; Laschi, Cecilia; Knoll, Alois C; Gewaltig, Marc-Oliver

2017-01-01

Combined efforts in the fields of neuroscience, computer science, and biology allowed to design biologically realistic models of the brain based on spiking neural networks. For a proper validation of these models, an embodiment in a dynamic and rich sensory environment, where the model is exposed to a realistic sensory-motor task, is needed. Due to the complexity of these brain models that, at the current stage, cannot deal with real-time constraints, it is not possible to embed them into a real-world task. Rather, the embodiment has to be simulated as well. While adequate tools exist to simulate either complex neural networks or robots and their environments, there is so far no tool that allows to easily establish a communication between brain and body models. The Neurorobotics Platform is a new web-based environment that aims to fill this gap by offering scientists and technology developers a software infrastructure allowing them to connect brain models to detailed simulations of robot bodies and environments and to use the resulting neurorobotic systems for in silico experimentation. In order to simplify the workflow and reduce the level of the required programming skills, the platform provides editors for the specification of experimental sequences and conditions, environments, robots, and brain-body connectors. In addition to that, a variety of existing robots and environments are provided. This work presents the architecture of the first release of the Neurorobotics Platform developed in subproject 10 "Neurorobotics" of the Human Brain Project (HBP). At the current state, the Neurorobotics Platform allows researchers to design and run basic experiments in neurorobotics using simulated robots and simulated environments linked to simplified versions of brain models. We illustrate the capabilities of the platform with three example experiments: a Braitenberg task implemented on a mobile robot, a sensory-motor learning task based on a robotic controller, and a

Astro-geodetic platform for high accuracy geoid determinat ion

NASA Astrophysics Data System (ADS)

Bǎdescu, Octavian; Nedelcu, Dan Alin; Cǎlin, Alexandru; Dumitru, Paul Daniel; Cǎlin, Lavinia A.; Popescu, Marcel

The paper presents first technical realizations of a mobile platform for vertical deviation determination at a satisfactory precision and low cost. The conception of the platform was made in the framework of a project regarding CCD astro-geodetic vertical deviation for geoid determination or geoid modeling. The project with the acronym A-GEO represents a collaboration between Technical University of Civil Engineering Bucharest - Faculty of Geodesy, (TUCEB-FG), Astronomical Institute of the Romanian academy (AIRA), and a private partner GeoGIS Proiect S.R.L. The paper presents some hardware and software aspects regarding design, development, and automation of the platform, based on an electro-optical geodetic instrument, CCD observations and satellite time synchronization for astro-geodetic measurements.

Development and case study of a science-based software platform to support policy making on air quality.

PubMed

Zhu, Yun; Lao, Yanwen; Jang, Carey; Lin, Chen-Jen; Xing, Jia; Wang, Shuxiao; Fu, Joshua S; Deng, Shuang; Xie, Junping; Long, Shicheng

2015-01-01

This article describes the development and implementations of a novel software platform that supports real-time, science-based policy making on air quality through a user-friendly interface. The software, RSM-VAT, uses a response surface modeling (RSM) methodology and serves as a visualization and analysis tool (VAT) for three-dimensional air quality data obtained by atmospheric models. The software features a number of powerful and intuitive data visualization functions for illustrating the complex nonlinear relationship between emission reductions and air quality benefits. The case study of contiguous U.S. demonstrates that the enhanced RSM-VAT is capable of reproducing the air quality model results with Normalized Mean Bias <2% and assisting in air quality policy making in near real time. Copyright © 2014. Published by Elsevier B.V.

The Research of China's Civil Aviation Passenger Multi-Channel Service Technology Platform

NASA Astrophysics Data System (ADS)

Zhibing, Xue; Xinming, Wang

IATA is promoting Simplifying the Business. The traditional passenger services and business process, such as ticketing, airport counters, had a great influence. The airlines have the passenger service and convenience as the next product development requirements. With civil aviation industry and their company's products construction, the authors propose a solution of passenger multi-channel service product platform. The solution is to streamline the business as the breakthrough point, around the convenience of passengers travel services to travelers as the center, using the current mainstream and the latest IT technology to establish passenger service product platform. The solution will promote DCS e-ticketing business development and service channel diversity. In this paper, the research results have been applied in the product platform construction of the authors' company. The practice shows that through traditional business with the latest IT technologies, traditional passenger services into the emerging service model, passenger service product platform has strong advantages and characteristics. Based on the platform, various types of service products is growing rapidly.

The Design and Implementation of Network Teaching Platform Basing on .NET

NASA Astrophysics Data System (ADS)

Yanna, Ren

This paper addresses the problem that students under traditional teaching model have poor operation ability and studies in depth the network teaching platform in domestic colleges and universities, proposing the design concept of network teaching platform of NET + C # + SQL excellent course and designing the overall structure, function module and back-end database of the platform. This paper emphatically expounds the use of MD5 encryption techniques in order to solve data security problems and the assessment of student learning using ADO.NET database access technology as well as the mathematical formula. The example shows that the network teaching platform developed by using WEB application technology has higher safety and availability, and thus improves the students' operation ability.

Model-Based Development of Automotive Electronic Climate Control Software

NASA Astrophysics Data System (ADS)

Kakade, Rupesh; Murugesan, Mohan; Perugu, Bhupal; Nair, Mohanan

With increasing complexity of software in today's products, writing and maintaining thousands of lines of code is a tedious task. Instead, an alternative methodology must be employed. Model-based development is one candidate that offers several benefits and allows engineers to focus on the domain of their expertise than writing huge codes. In this paper, we discuss the application of model-based development to the electronic climate control software of vehicles. The back-to-back testing approach is presented that ensures flawless and smooth transition from legacy designs to the model-based development. Simulink report generator to create design documents from the models is presented along with its usage to run the simulation model and capture the results into the test report. Test automation using model-based development tool that support the use of unique set of test cases for several testing levels and the test procedure that is independent of software and hardware platform is also presented.

Design, Modelling and Teleoperation of a 2 mm Diameter Compliant Instrument for the da Vinci Platform.

PubMed

Francis, P; Eastwood, K W; Bodani, V; Looi, T; Drake, J M

2018-05-07

This work explores the feasibility of creating and accurately controlling an instrument for robotic surgery with a 2 mm diameter and a three degree-of-freedom (DoF) wrist which is compatible with the da Vinci platform. The instrument's wrist is composed of a two DoF bending notched-nitinol tube pattern, for which a kinematic model has been developed. A base mechanism for controlling the wrist is designed for integration with the da Vinci Research Kit. A basic teleoperation task is successfully performed using two of the miniature instruments. The performance and accuracy of the instrument suggest that creating and accurately controlling a 2 mm diameter instrument is feasible and the design and modelling proposed in this work provide a basis for future miniature instrument development.

Web Platform Application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paulsworth, Ashley; Kurtz, Jim; Brun de Pontet, Stephanie

Sunvestment Energy Group (previously called Sunvestment Group) was established to create a web application that brings together site hosts, those who will obtain the energy from the solar array, with project developers and funders, including affinity investors. Sunvestment Energy Group (SEG) uses a community-based model that engages with investors who have some affinity with the site host organization. In addition to a financial return, these investors receive non-financial value from their investments and are therefore willing to offer lower cost capital. This enables the site host to enjoy more savings from solar through these less expensive Community Power Purchase Agreementsmore » (CPPAs). The purpose of this award was to develop an online platform to bring site hosts and investors together virtually.« less

Remotely Delivered Exercise-Based Cardiac Rehabilitation: Design and Content Development of a Novel mHealth Platform

PubMed Central

Gant, Nicholas; Meads, Andrew; Warren, Ian; Maddison, Ralph

2016-01-01

Background Participation in traditional center-based cardiac rehabilitation exercise programs (exCR) is limited by accessibility barriers. Mobile health (mHealth) technologies can overcome these barriers while preserving critical attributes of center-based exCR monitoring and coaching, but these opportunities have not yet been capitalized on. Objective We aimed to design and develop an evidence- and theory-based mHealth platform for remote delivery of exCR to any geographical location. Methods An iterative process was used to design and develop an evidence- and theory-based mHealth platform (REMOTE-CR) that provides real-time remote exercise monitoring and coaching, behavior change education, and social support. Results The REMOTE-CR platform comprises a commercially available smartphone and wearable sensor, custom smartphone and Web-based applications (apps), and a custom middleware. The platform allows exCR specialists to monitor patients’ exercise and provide individualized coaching in real-time, from almost any location, and provide behavior change education and social support. Intervention content incorporates Social Cognitive Theory, Self-determination Theory, and a taxonomy of behavior change techniques. Exercise components are based on guidelines for clinical exercise prescription. Conclusions The REMOTE-CR platform extends the capabilities of previous telehealth exCR platforms and narrows the gap between existing center- and home-based exCR services. REMOTE-CR can complement center-based exCR by providing an alternative option for patients whose needs are not being met. Remotely monitored exCR may be more cost-effective than establishing additional center-based programs. The effectiveness and acceptability of REMOTE-CR are now being evaluated in a noninferiority randomized controlled trial. PMID:27342791

PR-PR: Cross-Platform Laboratory Automation System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Linshiz, G; Stawski, N; Goyal, G

To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Goldenmore » Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.« less

Development of a phenotyping platform for high throughput screening of nodal root angle in sorghum.

PubMed

Joshi, Dinesh C; Singh, Vijaya; Hunt, Colleen; Mace, Emma; van Oosterom, Erik; Sulman, Richard; Jordan, David; Hammer, Graeme

2017-01-01

In sorghum, the growth angle of nodal roots is a major component of root system architecture. It strongly influences the spatial distribution of roots of mature plants in the soil profile, which can impact drought adaptation. However, selection for nodal root angle in sorghum breeding programs has been restricted by the absence of a suitable high throughput phenotyping platform. The aim of this study was to develop a phenotyping platform for the rapid, non-destructive and digital measurement of nodal root angle of sorghum at the seedling stage. The phenotyping platform comprises of 500 soil filled root chambers (50 × 45 × 0.3 cm in size), made of transparent perspex sheets that were placed in metal tubs and covered with polycarbonate sheets. Around 3 weeks after sowing, once the first flush of nodal roots was visible, roots were imaged in situ using an imaging box that included two digital cameras that were remotely controlled by two android tablets. Free software ( openGelPhoto.tcl ) allowed precise measurement of nodal root angle from the digital images. The reliability and efficiency of the platform was evaluated by screening a large nested association mapping population of sorghum and a set of hybrids in six independent experimental runs that included up to 500 plants each. The platform revealed extensive genetic variation and high heritability (repeatability) for nodal root angle. High genetic correlations and consistent ranking of genotypes across experimental runs confirmed the reproducibility of the platform. This low cost, high throughput root phenotyping platform requires no sophisticated equipment, is adaptable to most glasshouse environments and is well suited to dissect the genetic control of nodal root angle of sorghum. The platform is suitable for use in sorghum breeding programs aiming to improve drought adaptation through root system architecture manipulation.

Development of a prototype kinestatic platform for application to space and ground servicing tasks. Phase 1: Concept Modeling

NASA Technical Reports Server (NTRS)

Duffy, J.; Crane, C.

1993-01-01

The Center for Intelligent Machines and Robotics (CIMAR) of the University of Florida, in conjunction with Rockwell International is developing an electro-mechanical device called a Kinestatic Platform (KP) for aerospace applications. The goal of the current project is to develop a prototype KP which is capable of manipulating a 50 lb. payload. This prototype will demonstrate the feasibility of implementing a scaled up version to perform high precision manipulation of distributed systems and to control contact forces and allowable motions (rotations and translations), which is defined here as Kinestatic Control, in a six dimensional, partially constrained environment, simultaneously and independently. The objectives of the Phase 1 effort were as follows: (1) Identify specific NASA applications where the KP technology can be applied. (2) Select one application for development. (3) Develop a conceptual design of the KP specifically for the selected application. This includes the steps of developing a set of detailed performance criteria, establishing and making selection of the mechanism design parameters, and evaluating the expected system response. (4) Develop a computer graphics animation of the KP as it performs the selected application. This report will proceed by providing a technical description of the KP followed by how each of these objectives was addressed.

Development of the electromagnetic technology for broken rail detection from a mobil platform

NASA Astrophysics Data System (ADS)

Plotnikov, Yuri; Raghunathan, Arun; Kumar, Ajith; Noffsinger, Joseph; Fries, Jeffrey; Ehret, Steven; Frangieh, Tannous; Palanganda, Samhitha

2016-02-01

Timely detection of breaks in running rails remains a topic of significant importance for the railroad industry. GE has been investigating new ideas of the Rail Integrity Monitoring or RIM technology that can be implemented on a wide range of the rolling stock platforms including locomotives, passenger and freight cars. The focus of the project is to establish a simple, non-contact, and inexpensive means of nondestructive inspection by fusion of known solutions with new technology development that can result in detection with high reliability. A scaled down model of a typical locomotive-track system has been developed at GE Global research for detailed study of the detection process. In addition, a finite element model has been established and used to understand distribution of the magnetic field and currents in such a system. Both models have been using the rails and wheel-axles geometry to establish a realistic model that would provide the electric current and magnetic field distribution close to the real world phenomenon. Initial magnetic field maps were obtained by scanning a 1:15 model constructed of steel bars using a 3D scanner and an inductive coil. Sensitivity to a broken rail located between two locomotive axles simulated by an opening in this metallic frame was demonstrated. Further investigation and optimization was conducted on a larger, 1:3 scale, physical model and by running mathematical simulations. Special attention was paid to consistency between the finite element and physical model results. The obtained results allowed establishment of a working frequency range, inductive current injection into the rail-wheel-axle loop and measuring the electromagnetic response to a broken rail. The verification and full scale system prototype tests are following the laboratory experiments and mathematical simulations.

Vaccine platforms to control Lassa fever.

PubMed

Lukashevich, Igor S; Pushko, Peter

2016-09-01

Lassa virus (LASV), the most prominent human pathogen of the Arenaviridae, is transmitted to humans from infected rodents and can cause Lassa Fever (LF). The sizeable disease burden in West Africa, numerous imported LF cases worldwide, and the possibility that LASV can be used as an agent of biological warfare make a strong case for vaccine development. There are no licensed LASV vaccines and the antiviral treatment is limited to an off-label use of ribavirin that is only partially effective. LASV vaccine development is hampered by high cost of biocontainment requirement, the absence of appropriate small animal models, genetic diversity of LASV species, and by high HIV-1 prevalence in LASV endemic areas. Over the past 15 years several vaccine platforms have been developed. Natural history of LASV and pathogenesis of the disease provide strong justification for replication-competent (RC) vaccine as one of the most feasible approaches to control LF. Development of LASV vaccine candidates based on reassortant, recombinant, and alphavirus replicon technologies is covered in this review. Expert commentary: Two lead RC vaccine candidates, reassortant ML29 and recombinant VSV/LASV, have been successfully tested in non-human primates and have been recommended by international vaccine experts for rapid clinical development. Both platforms have powerful molecular tools to further secure safety, improve immunogenicity, and cross-protection. These platforms are well positioned to design multivalent vaccines to protect against all LASV strains citculatrd in West Africa. The regulatory pathway of Candid #1, the first live-attenuated arenaviral vaccine against Argentine hemorrhagic, will be a reasonable guideline for LASV vaccine efficacy trials.

Platform C North Arrival

NASA Image and Video Library

2016-08-30

A section of the second half of the C-level platforms, C North, for NASA’s Space Launch System (SLS) rocket, arrives at the agency’s Kennedy Space Center in Florida. The platform was offloaded from a heavy lift transport truck and secured in a staging area in the west parking lot of the Vehicle Assembly Building (VAB). The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Ride-sharing business model for sustainability in developing country: Case Study Nebengers, Indonesia

NASA Astrophysics Data System (ADS)

Asirin, Asirin; Azhari, Danang

2018-05-01

The growth of population and urban economy increased the need for humans’ mobility to support their activities. On the other hand, online Information and Communication Technology (ICT) is growing rapidly and more affordable. Within few years, there is some sharing economy business formed by using online platform. This condition brings through the emergence of ride-sharing business model using an online platform which can be beneficial to sustainability. This research aims to explore one of ridesharing business models which use the online platform and its impact on sustainability. This research used the procedure of case study method with a single case study of Nebengers. This research explores the case study with the scope of this research is limited by using several conceptual frameworks, they are sharing economy business model, four elements of a business model for sustainability (BMfS), Social Construction of Technology (SCoT), sustainable mobility and agency theory. Nebengers is a sharing economy business using online platform that historically can be explained using Social Construction of Technology (SCoT) Theory. There are conflicts between nebengers entrepreneur and the city government. Nebengers disrupts traditional and formal public transportation services which are managed by the government. However, nebengers also contributes to achieve the city government goal in developing sustainable mobility. The future challenge is how to arrange ride-sharing collaborative governance business model for sustainability in the cities in Indonesia.

Platform B North Installation

NASA Image and Video Library

2016-12-16

Construction workers wearing safety harnesses and tethered lines assist with the installation of the second half of the B-level work platforms, B north, for NASA’s Space Launch System (SLS) rocket, high up in the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida. They are securing the large bolts that hold the platform securely in place on the north side of High Bay 3. The B platforms are the ninth of 10 levels of work platforms that will surround and provide access to the SLS rocket and Orion spacecraft for Exploration Mission 1. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3, including installation of the new work platforms, to prepare for NASA’s Journey to Mars.

Development of a surface plasmon resonance and nanomechanical biosensing hybrid platform for multiparametric reading

NASA Astrophysics Data System (ADS)

Alvarez, Mar; Fariña, David; Escuela, Alfonso M.; Sendra, Jose Ramón; Lechuga, Laura M.

2013-01-01

We have developed a hybrid platform that combines two well-known biosensing technologies based on quite different transducer principles: surface plasmon resonance and nanomechanical sensing. The new system allows the simultaneous and real-time detection of two independent parameters, refractive index change (Δn), and surface stress change (Δσ) when a biomolecular interaction takes place. Both parameters have a direct relation with the mass coverage of the sensor surface. The core of the platform is a common fluid cell, where the solution arrives to both sensor areas at the same time and under the same conditions (temperature, velocity, diffusion, etc.).The main objective of this integration is to achieve a better understanding of the physical behaviour of the transducers during sensing, increasing the information obtained in real time in one single experiment. The potential of the hybrid platform is demonstrated by the detection of DNA hybridization.

Development of a surface plasmon resonance and nanomechanical biosensing hybrid platform for multiparametric reading.

PubMed

Alvarez, Mar; Fariña, David; Escuela, Alfonso M; Sendra, Jose Ramón; Lechuga, Laura M

2013-01-01

We have developed a hybrid platform that combines two well-known biosensing technologies based on quite different transducer principles: surface plasmon resonance and nanomechanical sensing. The new system allows the simultaneous and real-time detection of two independent parameters, refractive index change (Δn), and surface stress change (Δσ) when a biomolecular interaction takes place. Both parameters have a direct relation with the mass coverage of the sensor surface. The core of the platform is a common fluid cell, where the solution arrives to both sensor areas at the same time and under the same conditions (temperature, velocity, diffusion, etc.).The main objective of this integration is to achieve a better understanding of the physical behaviour of the transducers during sensing, increasing the information obtained in real time in one single experiment. The potential of the hybrid platform is demonstrated by the detection of DNA hybridization.

Experimental platform for intra-uterine needle placement procedures

NASA Astrophysics Data System (ADS)

Madjidi, Yashar; Haidegger, Tamás.; Ptacek, Wolfgang; Berger, Daniel; Kirisits, Christian; Kronreif, Gernot; Fichtinger, Gabor

2013-03-01

A framework has been investigated to enable a variety of comparative studies in the context of needle-based gynaecological brachytherapy. Our aim was to create an anthropomorphic phantom-based platform. The three main elements of the platform are the organ model, needle guide, and needle drive. These have been studied and designed to replicate the close environment of brachytherapy treatment for cervical cancer. Key features were created with the help of collaborating interventional radio-oncologists and the observations made in the operating room. A phantom box, representing the uterus model, has been developed considering available surgical analogies and operational limitations, such as organs at risk. A modular phantom-based platform has been designed and prototyped with the capability of providing various boundary conditions for the target organ. By mimicking the female pelvic floor, this framework has been used to compare a variety of needle insertion techniques and configurations for cervical and uterine interventions. The results showed that the proposed methodology is useful for the investigation of quantifiable experiments in the intraabdominal and pelvic regions.

New Insights into the Morphology of the Galapagos Platform from Lower Crustal Flow Models

NASA Astrophysics Data System (ADS)

Orellana Rovirosa, F.; Richards, M. A.

2014-12-01

The volcanically-active Galapagos Islands are constructed upon a broad platform, with the westernmost islands being the most active, marking the present-day position of the Galapagos hotspot (mantle plume). This volcanic platform overlies relatively young oceanic lithosphere (<15 Myr) and exhibits unique morphologic features along its boundaries. The most spectacular of these features is a system of stepped terraces on the southwestern escarpment, with very large vertical relief (>3 km), and contrasting with relatively gentle slopes off the eastern platform edge toward the Carnegie ridge. Considering the horizontal lithostatic pressure differences associated with this bathymetric relief, along with the high temperatures within this young, hotspot-affected oceanic lithosphere and crust; it is likely that lower crustal flow contributes significantly, perhaps even dominantly, to lithospheric and crustal deformation within the Galapagos Platform. Using 2D numerical models that invoke a thin-sheet approximation for the Stokes' equation for a Newtonian fluid with space- and time-dependent viscosity, and assuming isostatic conditions, we show that: (1) the pronounced bathymetric rim along the Eastern platform region (where gravimetric studies indicate Airy isostasy) near Española Island may be the expression of a mature stage of a lower crustal flow front evolving asymptotically during the last ~3 Myr; (2) the spectacular system of stepped terraces along the southwestern edge of the platform may be explained by lower crustal flow-associated backward tilting of the bathymetric surface that, even with small amounts of angular change (~0.1 deg) and potentially occurring in non-isostatic regimes, effectively hinders the horizontal flow of lava. This process of backward-tilting may have been largely restricted to the last ~1 Myr of platform growth, and hence may be a unique event that may involve horizontal extrusion of large lava sheets from within the southwestward

Evidence and models for lower crustal flow beneath the Galápagos platform

NASA Astrophysics Data System (ADS)

Orellana-Rovirosa, Felipe; Richards, Mark

2016-01-01

The volcanic Galápagos Islands are constructed upon a broad platform, with their active westernmost islands marking the current position of the hotspot. Built upon young oceanic lithosphere (<15 Ma), this platform exhibits unique morphologic features including a system of stepped terraces on the southwestern escarpment with 3 km relief, contrasting with gentle slopes off the eastern platform toward the Carnegie Ridge. Considering horizontal lithostatic pressure differences associated with this relief, along with high temperatures within the young, hotspot-affected lithosphere, it is likely that lower crustal flow contributes significantly to crustal deformation within the Galápagos platform. Using a 2-D, isostatic, thin-sheet approximation for the Stokes flow equation with (Newtonian) space-time-dependent viscosity, we suggest that the bathymetric rim along the eastern platform region (where gravimetry indicates Airy isostasy) near Española Island may be the expression of a mature lower crustal flow front developed over the last ˜3 Myr; horizontal mass displacements (˜50 km) associated with this crustal flow episode may have advected mantle plume geochemical signatures toward the southeast, and in directions not necessarily parallel to the hotspot track. Also, the stepped terraces along the southwestern platform may be explained by lower crustal flow-associated backward tilting of the bathymetric surface that, although resulting in small angular changes (˜0.1°), effectively hinders the horizontal flow of lava sheets. This backward-tilting process was likely restricted to the last ˜1 Ma or less, and may be a unique event involving extrusion of lavas from within the southwestward-marching lower-crustal flow front.

OTEC Cold Water Pipe-Platform Subsystem Dynamic Interaction Validation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Varley, Robert; Halkyard, John; Johnson, Peter

A commercial floating 100-megawatt (MW) ocean thermal energy conversion (OTEC) power plant will require a cold water pipe (CWP) with a diameter of 10-meter (m) and length of up to 1,000 m. The mass of the cold water pipe, including entrained water, can exceed the mass of the platform supporting it. The offshore industry uses software-modeling tools to develop platform and riser (pipe) designs to survive the offshore environment. These tools are typically validated by scale model tests in facilities able to replicate real at-sea meteorological and ocean (metocean) conditions to provide the understanding and confidence to proceed to finalmore » design and full-scale fabrication. However, today’s offshore platforms (similar to and usually larger than those needed for OTEC applications) incorporate risers (or pipes) with diameters well under one meter. Secondly, the preferred construction method for large diameter OTEC CWPs is the use of composite materials, primarily a form of fiber-reinforced plastic (FRP). The use of these material results in relatively low pipe stiffness and large strains compared to steel construction. These factors suggest the need for further validation of offshore industry software tools. The purpose of this project was to validate the ability to model numerically the dynamic interaction between a large cold water-filled fiberglass pipe and a floating OTEC platform excited by metocean weather conditions using measurements from a scale model tested in an ocean basin test facility.« less

The vacuum platform

NASA Astrophysics Data System (ADS)

McNab, A.

2017-10-01

This paper describes GridPP’s Vacuum Platform for managing virtual machines (VMs), which has been used to run production workloads for WLCG and other HEP experiments. The platform provides a uniform interface between VMs and the sites they run at, whether the site is organised as an Infrastructure-as-a-Service cloud system such as OpenStack, or an Infrastructure-as-a-Client system such as Vac. The paper describes our experience in using this platform, in developing and operating VM lifecycle managers Vac and Vcycle, and in interacting with VMs provided by LHCb, ATLAS, ALICE, CMS, and the GridPP DIRAC service to run production workloads.

Geostationary platform systems concepts definition study. Volume 2: Technical, book 1

NASA Technical Reports Server (NTRS)

1980-01-01

The initial selection and definition of operational geostationary platform concepts is discussed. Candidate geostationary platform missions and payloads were identified from COMSAT, Aerospace, and NASA studies. These missions and payloads were cataloged; classified with to communications, military, or scientific uses; screened for application and compatibility with geostationary platforms; and analyzed to identify platform requirements. Two platform locations were then selected (Western Hemisphere - 110 deg W, and Atlantic - 15 deg W), and payloads allocated based on nominal and high traffic models. Trade studies were performed leading to recommendation of selected concepts. Of 30 Orbit Transfer Vehicle (0TV) configuration and operating mode options identified, 18 viable candidates compatible with the operational geostationary platform missions were selected for analysis. Each was considered using four platform operational modes - 8 or 16 year life, and serviced or nonserviced, providing a total of 72 OTV/platform-mode options. For final trade study concept selection, a cost program was developed considering payload and platform costs and weight; transportation unit and total costs for the shuttle and OTV; and operational costs such as assembly or construction time, mating time, and loiter time. Servicing costs were added for final analysis and recommended selection.

[Dental education for college students based on WeChat public platform].

PubMed

Chen, Chuan-Jun; Sun, Tan

2016-06-01

The authors proposed a model for dental education based on WeChat public platform. In this model, teachers send various kinds of digital teaching information such as PPT，word and video to the WeChat public platform and students share the information for preview before class and differentiate the key-point knowledge from those information for in-depth learning in class. Teachers also send reference materials for expansive learning after class. Questionaire through the WeChat public platform is used to evaluate teaching effect of teachers and improvement may be taken based on the feedback questionnaire. A discussion and interaction based on WeCchat between students and teacher can be aroused on a specific topic to reach a proper solution. With technique development of mobile terminal, mobile class will come true in near future.

Development of a simulation model of semi-active suspension for monorail

NASA Astrophysics Data System (ADS)

Hasnan, K.; Didane, D. H.; Kamarudin, M. A.; Bakhsh, Qadir; Abdulmalik, R. E.

2016-11-01

The new Kuala Lumpur Monorail Fleet Expansion Project (KLMFEP) uses semiactive technology in its suspension system. It is recognized that the suspension system influences the ride quality. Thus, among the way to further improve the ride quality is by fine- tuning the semi-active suspension system on the new KL Monorail. The semi-active suspension for the monorail specifically in terms of improving ride quality could be exploited further. Hence a simulation model which will act as a platform to test the design of a complete suspension system particularly to investigate the ride comfort performance is required. MSC Adams software was considered as the tool to develop the simulation platform, where all parameters and data are represented by mathematical equations; whereas the new KL Monorail being the reference model. In the simulation, the model went through step disturbance on the guideway for stability and ride comfort analysis. The model has shown positive results where the monorail is in stable condition as an outcome from stability analysis. The model also scores a Rating 1 classification in ISO 2631 Ride Comfort performance which is very comfortable as an overall outcome from ride comfort analysis. The model is also adjustable, flexibile and understandable by the engineers within the field for the purpose of further development.

Localized Surface Plasmon Resonance as a Biosensing Platform for Developing Countries

PubMed Central

Hammond, Jules L.; Bhalla, Nikhil; Rafiee, Sarah D.; Estrela, Pedro

2014-01-01

The discovery of the phenomena known as localized surface plasmon resonance (LSPR) has provided the basis for many research areas, ranging from materials science to biosensing. LSPR has since been viewed as a transduction platform that could yield affordable, portable devices for a multitude of applications. This review aims to outline the potential applications within developing countries and the challenges that are likely to be faced before the technology can be effectively employed. PMID:25587417

A Distributed Platform for Global-Scale Agent-Based Models of Disease Transmission

PubMed Central

Parker, Jon; Epstein, Joshua M.

2013-01-01

The Global-Scale Agent Model (GSAM) is presented. The GSAM is a high-performance distributed platform for agent-based epidemic modeling capable of simulating a disease outbreak in a population of several billion agents. It is unprecedented in its scale, its speed, and its use of Java. Solutions to multiple challenges inherent in distributing massive agent-based models are presented. Communication, synchronization, and memory usage are among the topics covered in detail. The memory usage discussion is Java specific. However, the communication and synchronization discussions apply broadly. We provide benchmarks illustrating the GSAM’s speed and scalability. PMID:24465120

OpenQuake, a platform for collaborative seismic hazard and risk assessment

NASA Astrophysics Data System (ADS)

Henshaw, Paul; Burton, Christopher; Butler, Lars; Crowley, Helen; Danciu, Laurentiu; Nastasi, Matteo; Monelli, Damiano; Pagani, Marco; Panzeri, Luigi; Simionato, Michele; Silva, Vitor; Vallarelli, Giuseppe; Weatherill, Graeme; Wyss, Ben

2013-04-01

Sharing of data and risk information, best practices, and approaches across the globe is key to assessing risk more effectively. Through global projects, open-source IT development and collaborations with more than 10 regions, leading experts are collaboratively developing unique global datasets, best practice, tools and models for global seismic hazard and risk assessment, within the context of the Global Earthquake Model (GEM). Guided by the needs and experiences of governments, companies and international organisations, all contributions are being integrated into OpenQuake: a web-based platform that - together with other resources - will become accessible in 2014. With OpenQuake, stakeholders worldwide will be able to calculate, visualize and investigate earthquake hazard and risk, capture new data and share findings for joint learning. The platform is envisaged as a collaborative hub for earthquake risk assessment, used at global and local scales, around which an active network of users has formed. OpenQuake will comprise both online and offline tools, many of which can also be used independently. One of the first steps in OpenQuake development was the creation of open-source software for advanced seismic hazard and risk calculations at any scale, the OpenQuake Engine. Although in continuous development, a command-line version of the software is already being test-driven and used by hundreds worldwide; from non-profits in Central Asia, seismologists in sub-Saharan Africa and companies in South Asia to the European seismic hazard harmonization programme (SHARE). In addition, several technical trainings were organized with scientists from different regions of the world (sub-Saharan Africa, Central Asia, Asia-Pacific) to introduce the engine and other OpenQuake tools to the community, something that will continue to happen over the coming years. Other tools that are being developed of direct interest to the hazard community are: • OpenQuake Modeller; fundamental

Development and calibration of an air-floating six-axis force measurement platform using self-calibration

NASA Astrophysics Data System (ADS)

Huang, Bin; Wang, Xiaomeng; Li, Chengwei; Yi, Jiajing; Lu, Rongsheng; Tao, Jiayue

2016-09-01

This paper describes the design, working principle, as well as calibration of an air-floating six-axis force measurement platform, where the floating plate and nozzles were connected without contact, preventing inter-dimensional coupling and increasing precision significantly. The measurement repeatability error of the force size in the platform is less than 0.2% full scale (FS), which is significantly better than the precision of 1% FS in the six-axis force sensors on the current market. We overcame the difficulties of weight loading device in high-precision calibration by proposing a self-calibration method based on the floating plate gravity and met the calibration precision requirement of 0.02% FS. This study has general implications for the development and calibration of high-precision multi-axis force sensors. In particular, the air-floating six-axis force measurement platform could be applied to the calibration of some special sensors such as flexible tactile sensors and may be used as a micro-nano mechanical assembly platform for real-time assembly force testing.

Specification Patent Management for Web Application Platform Ecosystem

NASA Astrophysics Data System (ADS)

Fukami, Yoshiaki; Isshiki, Masao; Takeda, Hideaki; Ohmukai, Ikki; Kokuryo, Jiro

Diversified usage of web applications has encouraged disintegration of web platform into management of identification and applications. Users make use of various kinds of data linked to their identity with multiple applications on certain social web platforms such as Facebook or MySpace. There has emerged competition among web application platforms. Platformers can design relationship with developers by controlling patent of their own specification and adopt open technologies developed external organizations. Platformers choose a way to open according to feature of the specification and their position. Patent management of specification come to be a key success factor to build competitive web application platforms. Each way to attract external developers such as standardization, open source has not discussed and analyzed all together.

Toward an integrated software platform for systems pharmacology

PubMed Central

Ghosh, Samik; Matsuoka, Yukiko; Asai, Yoshiyuki; Hsin, Kun-Yi; Kitano, Hiroaki

2013-01-01

Understanding complex biological systems requires the extensive support of computational tools. This is particularly true for systems pharmacology, which aims to understand the action of drugs and their interactions in a systems context. Computational models play an important role as they can be viewed as an explicit representation of biological hypotheses to be tested. A series of software and data resources are used for model development, verification and exploration of the possible behaviors of biological systems using the model that may not be possible or not cost effective by experiments. Software platforms play a dominant role in creativity and productivity support and have transformed many industries, techniques that can be applied to biology as well. Establishing an integrated software platform will be the next important step in the field. © 2013 The Authors. Biopharmaceutics & Drug Disposition published by John Wiley & Sons, Ltd. PMID:24150748

Development and Validation of a Portable Platform for Deploying Decision-Support Algorithms in Prehospital Settings

PubMed Central

Reisner, A. T.; Khitrov, M. Y.; Chen, L.; Blood, A.; Wilkins, K.; Doyle, W.; Wilcox, S.; Denison, T.; Reifman, J.

2013-01-01

Summary Background Advanced decision-support capabilities for prehospital trauma care may prove effective at improving patient care. Such functionality would be possible if an analysis platform were connected to a transport vital-signs monitor. In practice, there are technical challenges to implementing such a system. Not only must each individual component be reliable, but, in addition, the connectivity between components must be reliable. Objective We describe the development, validation, and deployment of the Automated Processing of Physiologic Registry for Assessment of Injury Severity (APPRAISE) platform, intended to serve as a test bed to help evaluate the performance of decision-support algorithms in a prehospital environment. Methods We describe the hardware selected and the software implemented, and the procedures used for laboratory and field testing. Results The APPRAISE platform met performance goals in both laboratory testing (using a vital-sign data simulator) and initial field testing. After its field testing, the platform has been in use on Boston MedFlight air ambulances since February of 2010. Conclusion These experiences may prove informative to other technology developers and to healthcare stakeholders seeking to invest in connected electronic systems for prehospital as well as in-hospital use. Our experiences illustrate two sets of important questions: are the individual components reliable (e.g., physical integrity, power, core functionality, and end-user interaction) and is the connectivity between components reliable (e.g., communication protocols and the metadata necessary for data interpretation)? While all potential operational issues cannot be fully anticipated and eliminated during development, thoughtful design and phased testing steps can reduce, if not eliminate, technical surprises. PMID:24155791

Predicting Droplet Formation on Centrifugal Microfluidic Platforms

NASA Astrophysics Data System (ADS)

Moebius, Jacob Alfred

Centrifugal microfluidics is a widely known research tool for biological sample and water quality analysis. Currently, the standard equipment used for such diagnostic applications include slow, bulky machines controlled by multiple operators. These machines can be condensed into a smaller, faster benchtop sample-to-answer system. Sample processing is an important step taken to extract, isolate, and convert biological factors, such as nucleic acids or proteins, from a raw sample to an analyzable solution. Volume definition is one such step. The focus of this thesis is the development of a model predicting monodispersed droplet formation and the application of droplets as a technique for volume definition. First, a background of droplet microfluidic platforms is presented, along with current biological analysis technologies and the advantages of integrating such technologies onto microfluidic platforms. Second, background and theories of centrifugal microfluidics is given, followed by theories relevant to droplet emulsions. Third, fabrication techniques for centrifugal microfluidic designs are discussed. Finally, the development of a model for predicting droplet formation on the centrifugal microfluidic platform are presented for the rest of the thesis. Predicting droplet formation analytically based on the volumetric flow rates of the continuous and dispersed phases, the ratios of these two flow rates, and the interfacial tension between the continuous and dispersed phases presented many challenges, which will be discussed in this work. Experimental validation was completed using continuous phase solutions of different interfacial tensions. To conclude, prospective applications are discussed with expected challenges.

Platform C South Arrival

NASA Image and Video Library

2016-08-04

A heavy load transport truck from Tillett Heavy Hauling in Titusville, Florida, arrives at the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida, carrying a section of the first half of the C-level work platforms, C south, for the agency’s Space Launch System (SLS) rocket. The platform will be delivered to the VAB staging area in the west parking lot. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Automated platform for designing multiple robot work cells

NASA Astrophysics Data System (ADS)

Osman, N. S.; Rahman, M. A. A.; Rahman, A. A. Abdul; Kamsani, S. H.; Bali Mohamad, B. M.; Mohamad, E.; Zaini, Z. A.; Rahman, M. F. Ab; Mohamad Hatta, M. N. H.

2017-06-01

Designing the multiple robot work cells is very knowledge-intensive, intricate, and time-consuming process. This paper elaborates the development process of a computer-aided design program for generating the multiple robot work cells which offer a user-friendly interface. The primary purpose of this work is to provide a fast and easy platform for less cost and human involvement with minimum trial and errors adjustments. The automated platform is constructed based on the variant-shaped configuration concept with its mathematical model. A robot work cell layout, system components, and construction procedure of the automated platform are discussed in this paper where integration of these items will be able to automatically provide the optimum robot work cell design according to the information set by the user. This system is implemented on top of CATIA V5 software and utilises its Part Design, Assembly Design, and Macro tool. The current outcomes of this work provide a basis for future investigation in developing a flexible configuration system for the multiple robot work cells.

Blood glucose level prediction based on support vector regression using mobile platforms.

PubMed

Reymann, Maximilian P; Dorschky, Eva; Groh, Benjamin H; Martindale, Christine; Blank, Peter; Eskofier, Bjoern M

2016-08-01

The correct treatment of diabetes is vital to a patient's health: Staying within defined blood glucose levels prevents dangerous short- and long-term effects on the body. Mobile devices informing patients about their future blood glucose levels could enable them to take counter-measures to prevent hypo or hyper periods. Previous work addressed this challenge by predicting the blood glucose levels using regression models. However, these approaches required a physiological model, representing the human body's response to insulin and glucose intake, or are not directly applicable to mobile platforms (smart phones, tablets). In this paper, we propose an algorithm for mobile platforms to predict blood glucose levels without the need for a physiological model. Using an online software simulator program, we trained a Support Vector Regression (SVR) model and exported the parameter settings to our mobile platform. The prediction accuracy of our mobile platform was evaluated with pre-recorded data of a type 1 diabetes patient. The blood glucose level was predicted with an error of 19 % compared to the true value. Considering the permitted error of commercially used devices of 15 %, our algorithm is the basis for further development of mobile prediction algorithms.

Wind Turbine Controller to Mitigate Structural Loads on a Floating Wind Turbine Platform

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fleming, Paul A.; Peiffer, Antoine; Schlipf, David

This paper summarizes the control design work that was performed to optimize the controller of a wind turbine on the WindFloat structure. The WindFloat is a semi-submersible floating platform designed to be a support structure for a multi-megawatt power-generating wind turbine. A controller developed for a bottom-fixed wind turbine configuration was modified for use when the turbine is mounted on the WindFloat platform. This results in an efficient platform heel resonance mitigation scheme. In addition several control modules, designed with a coupled linear model, were added to the fixed-bottom baseline controller. The approach was tested in a fully coupled nonlinearmore » aero-hydroelastic simulation tool in which wind and wave disturbances were modeled. This testing yielded significant improvements in platform global performance and tower-base-bending loading.« less

Optimal design and experimental analyses of a new micro-vibration control payload-platform

NASA Astrophysics Data System (ADS)

Sun, Xiaoqing; Yang, Bintang; Zhao, Long; Sun, Xiaofen

2016-07-01

This paper presents a new payload-platform, for precision devices, which possesses the capability of isolating the complex space micro-vibration in low frequency range below 5 Hz. The novel payload-platform equipped with smart material actuators is investigated and designed through optimization strategy based on the minimum energy loss rate, for the aim of achieving high drive efficiency and reducing the effect of the magnetic circuit nonlinearity. Then, the dynamic model of the driving element is established by using the Lagrange method and the performance of the designed payload-platform is further discussed through the combination of the controlled auto regressive moving average (CARMA) model with modified generalized prediction control (MGPC) algorithm. Finally, an experimental prototype is developed and tested. The experimental results demonstrate that the payload-platform has an impressive potential of micro-vibration isolation.

Development of an information platform for new grid users in the biomedical field.

PubMed

Skrowny, Daniela; Dickmann, Frank; Löhnhardt, Benjamin; Knoch, Tobias A; Sax, Ulrich

2010-01-01

Bringing new users into grids is a top priority for all grid initiatives and one of the most challenging tasks. Especially in life sciences it is essential to have a certain amount of users to establish a critical mass for a sustainable grid and give feedback back to the technological middleware layer. Based on the presumable lack of grid IT knowledge it is notably more arduous to satisfy user demands although here the requirements are especially demanding. Therefore, the development of an information- and learning platform could support the efforts of grid experts to guide new users. By providing a platform about grid technology and their feasibilities for users of the community of biomedicine potential, users could be supported using the high potential of their discipline.

Parameters Identification for Motorcycle Simulator's Platform Characterization

NASA Astrophysics Data System (ADS)

Nehaoua, L.; Arioui, H.

2008-06-01

This paper presents the dynamics modeling and parameters identification of a motorcycle simulator's platform. This model begins with some suppositions which consider that the leg dynamics can be neglected with respect to the mobile platform one. The objectif is to synthesis a simplified control scheme, adapted to driving simulation application, minimising dealys and without loss of tracking performance. Electronic system of platform actuation is described. It's based on a CAN BUS communication which offers a large transmission robustness and error handling. Despite some disadvanteges, we adapted a control solution which overcome these inconvenients and preserve the quality of tracking trajectory. A bref description of the simulator's platform is given and results are shown and justified according to our specifications.

Workshop report: developing a pediatric inflammatory bowel diseases network and data platform in Canada.

PubMed

Sherman, Philip M; Brown, Sally; Rose, Keeley; Murphy, Tim; Makarchuk, Mary-Jo; Paterson, William; Belanger, Paul

2012-08-01

The purpose of the workshop was to receive input from the Canadian pediatric inflammatory bowel diseases research community to develop a research funding opportunity for a Canadian pediatric inflammatory bowel diseases network and data platform supported by the Canadian Institutes for Health Research, in partnership with the Foundation for Children with Intestinal and Liver Disorders. Leaders from across the country came together, with the objectives of identifying the scientific goals for a Canadian pediatric inflammatory bowel disease network, the required infrastructure, and an appropriate governance structure needed to achieve such a network and data platform, as well as other elements needed to ensure the successful implementation of a network.

Normal Brain-Skull Development with Hybrid Deformable VR Models Simulation.

PubMed

Jin, Jing; De Ribaupierre, Sandrine; Eagleson, Roy

2016-01-01

This paper describes a simulation framework for a clinical application involving skull-brain co-development in infants, leading to a platform for craniosynostosis modeling. Craniosynostosis occurs when one or more sutures are fused early in life, resulting in an abnormal skull shape. Surgery is required to reopen the suture and reduce intracranial pressure, but is difficult without any predictive model to assist surgical planning. We aim to study normal brain-skull growth by computer simulation, which requires a head model and appropriate mathematical methods for brain and skull growth respectively. On the basis of our previous model, we further specified suture model into fibrous and cartilaginous sutures and develop algorithm for skull extension. We evaluate the resulting simulation by comparison with datasets of cases and normal growth.

Dielectric spectroscopy platform to measure MCF10A epithelial cell aggregation as a model for spheroidal cell cluster analysis.

PubMed

Heileman, K L; Tabrizian, M

2017-05-02

3-Dimensional cell cultures are more representative of the native environment than traditional cell cultures on flat substrates. As a result, 3-dimensional cell cultures have emerged as a very valuable model environment to study tumorigenesis, organogenesis and tissue regeneration. Many of these models encompass the formation of cell aggregates, which mimic the architecture of tumor and organ tissue. Dielectric impedance spectroscopy is a non-invasive, label free and real time technique, overcoming the drawbacks of established techniques to monitor cell aggregates. Here we introduce a platform to monitor cell aggregation in a 3-dimensional extracellular matrix using dielectric spectroscopy. The MCF10A breast epithelial cell line serves as a model for cell aggregation. The platform maintains sterile conditions during the multi-day assay while allowing continuous dielectric spectroscopy measurements. The platform geometry optimizes dielectric measurements by concentrating cells within the electrode sensing region. The cells show a characteristic dielectric response to aggregation which corroborates with finite element analysis computer simulations. By fitting the experimental dielectric spectra to the Cole-Cole equation, we demonstrated that the dispersion intensity Δε and the characteristic frequency f c are related to cell aggregate growth. In addition, microscopy can be performed directly on the platform providing information about cell position, density and morphology. This platform could yield many applications for studying the electrophysiological activity of cell aggregates.

Connecting Artificial Brains to Robots in a Comprehensive Simulation Framework: The Neurorobotics Platform

PubMed Central

Falotico, Egidio; Vannucci, Lorenzo; Ambrosano, Alessandro; Albanese, Ugo; Ulbrich, Stefan; Vasquez Tieck, Juan Camilo; Hinkel, Georg; Kaiser, Jacques; Peric, Igor; Denninger, Oliver; Cauli, Nino; Kirtay, Murat; Roennau, Arne; Klinker, Gudrun; Von Arnim, Axel; Guyot, Luc; Peppicelli, Daniel; Martínez-Cañada, Pablo; Ros, Eduardo; Maier, Patrick; Weber, Sandro; Huber, Manuel; Plecher, David; Röhrbein, Florian; Deser, Stefan; Roitberg, Alina; van der Smagt, Patrick; Dillman, Rüdiger; Levi, Paul; Laschi, Cecilia; Knoll, Alois C.; Gewaltig, Marc-Oliver

2017-01-01

Combined efforts in the fields of neuroscience, computer science, and biology allowed to design biologically realistic models of the brain based on spiking neural networks. For a proper validation of these models, an embodiment in a dynamic and rich sensory environment, where the model is exposed to a realistic sensory-motor task, is needed. Due to the complexity of these brain models that, at the current stage, cannot deal with real-time constraints, it is not possible to embed them into a real-world task. Rather, the embodiment has to be simulated as well. While adequate tools exist to simulate either complex neural networks or robots and their environments, there is so far no tool that allows to easily establish a communication between brain and body models. The Neurorobotics Platform is a new web-based environment that aims to fill this gap by offering scientists and technology developers a software infrastructure allowing them to connect brain models to detailed simulations of robot bodies and environments and to use the resulting neurorobotic systems for in silico experimentation. In order to simplify the workflow and reduce the level of the required programming skills, the platform provides editors for the specification of experimental sequences and conditions, environments, robots, and brain–body connectors. In addition to that, a variety of existing robots and environments are provided. This work presents the architecture of the first release of the Neurorobotics Platform developed in subproject 10 “Neurorobotics” of the Human Brain Project (HBP).1 At the current state, the Neurorobotics Platform allows researchers to design and run basic experiments in neurorobotics using simulated robots and simulated environments linked to simplified versions of brain models. We illustrate the capabilities of the platform with three example experiments: a Braitenberg task implemented on a mobile robot, a sensory-motor learning task based on a robotic controller

GetHealthyHarlem.org: Developing a Web Platform for Health Promotion and Wellness Driven by and for the Harlem Community

PubMed Central

Khan, Sharib A.; Ancker, Jessica S.; Li, Jianhua; Kaufman, David; Hutchinson, Carly; Cohall, Alwyn; Kukafka, Rita

2009-01-01

GetHealthyHarlem.org is a community website developed on an open-source platform to facilitate collaborative development of health content through participatory action research (PAR) principles. The website was developed to enable the Harlem community to create a shared health and wellness knowledgebase, to enable discourse about local and culturally relevant health information, and to foster social connections between community members and health promotion organizations. The site is gaining active use with more than 9,500 unique site visits in the six months since going live in November, 2008. In ongoing research studies, we are using the website to explore how the PAR model can be applied to the development of a community health website. PMID:20351872

Design and control of multifunctional sorting and training platform based on PLC control

NASA Astrophysics Data System (ADS)

Wan, Hongqiang; Ge, Shuai; Han, Peiying; Li, Fancong; Zhang, Simiao

2018-05-01

Electromechanical integration, as a multi-disciplinary subject, has been paid much attention by universities and is widely used in the automation production of enterprises. Aiming at the problem of the lack of control among enterprises and the lack of training among colleges and universities, this paper presents a design of multifunctional sorting training platform based on PLC control. Firstly, the structure of the platform is determined and three-dimensional modeling is done. Then design the platform's aerodynamic control and electrical control. Finally, realize the platform sorting function through PLC programming and configuration software development. The training platform can be used to design the practical training experiment, which has a strong advance and pertinence in the electromechanical integration teaching. At the same time, the platform makes full use of modular thinking to make the sorting modules more flexible. Compared with the traditional training platform, its teaching effect is more significant.

Urban water-quality modelling: implementing an extension to Multi-Hydro platform for real case studies

NASA Astrophysics Data System (ADS)

Hong, Yi; Giangola-Murzyn, Agathe; Bonhomme, Celine; Chebbo, Ghassan; Schertzer, Daniel

2015-04-01

During the last few years, the physically based and fully distributed numerical platform Multi-Hydro (MH) has been developed to simulate hydrological behaviours in urban/peri-urban areas (El-Tabach et al. , 2009 ; Gires et al., 2013 ; Giangola-Murzyn et al., 2014). This hydro-dynamical platform is open-access and has a modular structure, which is designed to be easily scalable and transportable, in order to simulate the dynamics and complex interactions of the water cycle processes in urban or peri-urban environment (surface hydrology, urban groundwater infrastructures and infiltration). Each hydrological module relies on existing and widely validated open source models, such as TREX model (Velleux, 2005) for the surface module, SWMM model (Rossman, 2010) for the drainage module and VS2DT model (Lappala et al., 1987) for the soil module. In our recent studies, an extension of MH has been set up by connecting the already available water-quality computational components among different modules, to introduce a pollutant transport modelling into the hydro-dynamical platform. As for the surface module in two-dimensions, the concentration of particles in flow is expressed by sediment advection equation, the settling of suspended particles is calculated with a simplified settling velocity formula, while the pollutant wash-off from a given land-use is represented as a mass rate of particle removal from the bottom boundary over time, based on transport capacity, which is computed by a modified form of Universal Soil Loss Equation (USLE). Considering that the USLE is originally conceived to predict soil losses caused by runoff in agriculture areas, several adaptations were needed to use it for urban areas, such as the alterations of USLE parameters according to different criterions, the definition of the appropriate initial dust thickness corresponding to various land-uses, etc. Concerning the drainage module, water quality routing within pipes assumes that the conduit

Platform C South Arrival

NASA Image and Video Library

2016-08-04

A heavy load transport truck from Tillett Heavy Hauling in Titusville, Florida, arrives at the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida, carrying a section of the first half of the C-level work platforms, C South, for the agency’s Space Launch System (SLS) rocket. The platform is being lifted and transferred onto support stands in the VAB staging area in the west parking lot. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Platform C South Arrival

NASA Image and Video Library

2016-08-05

A heavy load transport truck from Tillett Heavy Hauling in Titusville, Florida, arrives at the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center in Florida, carrying the second section of the first half of the C-level work platforms, C South, for the agency’s Space Launch System (SLS) rocket. The platform will be offloaded in the VAB staging area in the west parking lot. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

An open platform for personal health record apps with platform-level privacy protection.

PubMed

Van Gorp, P; Comuzzi, M; Jahnen, A; Kaymak, U; Middleton, B

2014-08-01

One of the main barriers to the adoption of Personal Health Records (PHR) systems is their closed nature. It has been argued in the literature that this barrier can be overcome by introducing an open market of substitutable PHR apps. The requirements introduced by such an open market on the underlying platform have also been derived. In this paper, we argue that MyPHRMachines, a cloud-based PHR platform recently developed by the authors, satisfies these requirements better than its alternatives. The MyPHRMachines platform leverages Virtual Machines as flexible and secure execution sandboxes for health apps. MyPHRMachines does not prevent pushing hospital- or patient-generated data to one of its instances, nor does it prevent patients from sharing data with their trusted caregivers. External software developers have minimal barriers to contribute innovative apps to the platform, since apps are only required to avoid pushing patient data outside a MyPHRMachines cloud. We demonstrate the potential of MyPHRMachines by presenting two externally contributed apps. Both apps provide functionality going beyond the state-of-the-art in their application domain, while they did not require any specific MyPHRMachines platform extension. Copyright © 2014 Elsevier Ltd. All rights reserved.

SERVIR-Africa: Developing an Integrated Platform for Floods Disaster Management in Africa

NASA Technical Reports Server (NTRS)

Macharia, Daniel; Korme, Tesfaye; Policelli, Fritz; Irwin, Dan; Adler, Bob; Hong, Yang

2010-01-01

SERVIR-Africa is an ambitious regional visualization and monitoring system that integrates remotely sensed data with predictive models and field-based data to monitor ecological processes and respond to natural disasters. It aims addressing societal benefits including floods and turning data into actionable information for decision-makers. Floods are exogenous disasters that affect many parts of Africa, probably second only to drought in terms of social-economic losses. This paper looks at SERVIR-Africa's approach to floods disaster management through establishment of an integrated platform, floods prediction models, post-event flood mapping and monitoring as well as flood maps dissemination in support of flood disaster management.

Unmanned Instrument Platform for Undersea Exploration

NASA Technical Reports Server (NTRS)

Paine, G.; Hansen, G. R.; Gulizia, R. W.; Paluzzi, P.

1984-01-01

Instruments accommodated on moving underwater platform. Towable underwater platform 3.2 meters long, 1.2 meters wide, 1.4 meters high and has mass of about 1,250 kilogram. Platform remotely operated and unmanned. Serves as test bed for development of ocean-measuring instruments and sonars at depths to 20,000 feet.

Coupled Modeling of Hydrodynamics and Sound in Coastal Ocean for Renewable Ocean Energy Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Long, Wen; Jung, Ki Won; Yang, Zhaoqing

An underwater sound model was developed to simulate sound propagation from marine and hydrokinetic energy (MHK) devices or offshore wind (OSW) energy platforms. Finite difference methods were developed to solve the 3D Helmholtz equation for sound propagation in the coastal environment. A 3D sparse matrix solver with complex coefficients was formed for solving the resulting acoustic pressure field. The Complex Shifted Laplacian Preconditioner (CSLP) method was applied to solve the matrix system iteratively with MPI parallelization using a high performance cluster. The sound model was then coupled with the Finite Volume Community Ocean Model (FVCOM) for simulating sound propagation generatedmore » by human activities, such as construction of OSW turbines or tidal stream turbine operations, in a range-dependent setting. As a proof of concept, initial validation of the solver is presented for two coastal wedge problems. This sound model can be useful for evaluating impacts on marine mammals due to deployment of MHK devices and OSW energy platforms.« less

Low Emission Development Strategies: The Role of Networks and Knowledge Platforms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benioff, Ron; Bazilian, Morgan; Cox, Sadie

2013-09-01

Considerable effort has been made to address the transition to low-carbon economy. A key focus of these efforts has been on the development of national low-emissions developments strategies (LEDS). One enabler of these plans is the existence of well-functioning national, regional and international low-emission development networks and knowledge platforms. To better understand the role of LEDS, weexamine this area in relation to network theory. We present a review of strengths and weaknesses of existing LEDS networks that builds on the findings of a study conducted by the Coordinated Low Emission Assistance Network (CLEAN). Based on the insights from theory andmore » a mapping of the climate-related network space, we identify opportunities for further refinement of LEDS networks.« less

The Design and Development of Test Platform for Wheat Precision Seeding Based on Image Processing Techniques

NASA Astrophysics Data System (ADS)

Li, Qing; Lin, Haibo; Xiu, Yu-Feng; Wang, Ruixue; Yi, Chuijie

The test platform of wheat precision seeding based on image processing techniques is designed to develop the wheat precision seed metering device with high efficiency and precision. Using image processing techniques, this platform gathers images of seeds (wheat) on the conveyer belt which are falling from seed metering device. Then these data are processed and analyzed to calculate the qualified rate, reseeding rate and leakage sowing rate, etc. This paper introduces the whole structure, design parameters of the platform and hardware & software of the image acquisition system were introduced, as well as the method of seed identification and seed-space measurement using image's threshold and counting the seed's center. By analyzing the experimental result, the measurement error is less than ± 1mm.

Interactions between avidin and graphene for development of a biosensing platform.

PubMed

Macwan, Isaac; Khan, Md Daud Hossain; Aphale, Ashish; Singh, Shrishti; Liu, Juan; Hingorani, Manju; Patra, Prabir

2017-03-15

Fundamental understanding of interactions at the interface of biological molecules, such as proteins, and nanomaterials is crucial for developing various biocompatible hybrid materials and biosensing platforms. Biosensors comprising of graphene-based conductive nanomaterials offer the advantage of higher sensitivity and reliable diagnosis mainly due to their superior specific surface area and ballistic conductivity. Furthermore, conductive nanocomposite structures that immobilize proteins can synergize the properties of both transducers and molecular recognition elements improving the performance of the biosensing device. Here we report for the first time, using a combined molecular dynamics simulations and experimental approach, the interactions between avidin and graphene for the development of a sensing platform that can be used for the detection of biological macromolecules such as mismatch repair proteins through biotinylated DNA substrates. We find that the interactive forces between avidin and graphene are mainly hydrophobic, along with some van der Waals, electrostatic and hydrogen bonding interactions. Notably, the structure and function of the avidin molecule are largely preserved after its adsorption on the graphene surface. The MD results agree well with scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS) analysis of avidin immobilized on a graphenated polypyrrole (G-PPy) conductive nanocomposite confirming the adsorption of avidin on graphene nanoplatelets as observed from the Fourier-transform infrared spectroscopy (FTIR). Copyright © 2016 Elsevier B.V. All rights reserved.

Weathering the Storm: Developing a Spatial Data Infrastructure and Online Research Platform for Oil Spill Preparedness

NASA Astrophysics Data System (ADS)

Bauer, J. R.; Rose, K.; Romeo, L.; Barkhurst, A.; Nelson, J.; Duran-Sesin, R.; Vielma, J.

2016-12-01

Efforts to prepare for and reduce the risk of hazards, from both natural and anthropogenic sources, which threaten our oceans and coasts requires an understanding of the dynamics and interactions between the physical, ecological, and socio-economic systems. Understanding these coupled dynamics are essential as offshore oil & gas exploration and production continues to push into harsher, more extreme environments where risks and uncertainty increase. However, working with these large, complex data from various sources and scales to assess risks and potential impacts associated with offshore energy exploration and production poses several challenges to research. In order to address these challenges, an integrated assessment model (IAM) was developed at the Department of Energy's (DOE) National Energy Technology Laboratory (NETL) that combines spatial data infrastructure and an online research platform to manage, process, analyze, and share these large, multidimensional datasets, research products, and the tools and models used to evaluate risk and reduce uncertainty for the entire offshore system, from the subsurface, through the water column, to coastal ecosystems and communities. Here, we will discuss the spatial data infrastructure and online research platform, NETL's Energy Data eXchange (EDX), that underpin the offshore IAM, providing information on how the framework combines multidimensional spatial data and spatio-temporal tools to evaluate risks to the complex matrix of potential environmental, social, and economic impacts stemming from modeled offshore hazard scenarios, such as oil spills or hurricanes. In addition, we will discuss the online analytics, tools, and visualization methods integrated into this framework that support availability and access to data, as well as allow for the rapid analysis and effective communication of analytical results to aid a range of decision-making needs.

Maritime Platform Sleep and Performance Study: Evaluating the SAFTE Model for Maritime Workplace Application

DTIC Science & Technology

2012-06-01

SLEEP AND PERFORMANCE STUDY: EVALUATING THE SAFTE MODEL FOR MARITIME WORKPLACE APPLICATION by Stephanie A. T. Brown June 2012 Thesis...REPORT DATE June 2012 3. REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE Maritime Platform Sleep and Performance Study...Evaluating the SAFTE Model for Maritime Workplace Application 5. FUNDING NUMBERS 6. AUTHOR(S) Stephanie A. T. Brown 7. PERFORMING ORGANIZATION

Institutional profile: the national Swedish academic drug discovery & development platform at SciLifeLab

PubMed Central

Arvidsson, Per I; Sandberg, Kristian; Sakariassen, Kjell S

2017-01-01

The Science for Life Laboratory Drug Discovery and Development Platform (SciLifeLab DDD) was established in Stockholm and Uppsala, Sweden, in 2014. It is one of ten platforms of the Swedish national SciLifeLab which support projects run by Swedish academic researchers with large-scale technologies for molecular biosciences with a focus on health and environment. SciLifeLab was created by the coordinated effort of four universities in Stockholm and Uppsala: Stockholm University, Karolinska Institutet, KTH Royal Institute of Technology and Uppsala University, and has recently expanded to other Swedish university locations. The primary goal of the SciLifeLab DDD is to support selected academic discovery and development research projects with tools and resources to discover novel lead therapeutics, either molecules or human antibodies. Intellectual property developed with the help of SciLifeLab DDD is wholly owned by the academic research group. The bulk of SciLifeLab DDD's research and service activities are funded from the Swedish state, with only consumables paid by the academic research group through individual grants. PMID:28670468

Institutional profile: the national Swedish academic drug discovery & development platform at SciLifeLab.

PubMed

Arvidsson, Per I; Sandberg, Kristian; Sakariassen, Kjell S

2017-06-01

The Science for Life Laboratory Drug Discovery and Development Platform (SciLifeLab DDD) was established in Stockholm and Uppsala, Sweden, in 2014. It is one of ten platforms of the Swedish national SciLifeLab which support projects run by Swedish academic researchers with large-scale technologies for molecular biosciences with a focus on health and environment. SciLifeLab was created by the coordinated effort of four universities in Stockholm and Uppsala: Stockholm University, Karolinska Institutet, KTH Royal Institute of Technology and Uppsala University, and has recently expanded to other Swedish university locations. The primary goal of the SciLifeLab DDD is to support selected academic discovery and development research projects with tools and resources to discover novel lead therapeutics, either molecules or human antibodies. Intellectual property developed with the help of SciLifeLab DDD is wholly owned by the academic research group. The bulk of SciLifeLab DDD's research and service activities are funded from the Swedish state, with only consumables paid by the academic research group through individual grants.

Interfacing modeling suite Physics Of Eclipsing Binaries 2.0 with a Virtual Reality Platform

NASA Astrophysics Data System (ADS)

Harriett, Edward; Conroy, Kyle; Prša, Andrej; Klassner, Frank

2018-01-01

To explore alternate methods for modeling eclipsing binary stars, we extrapolate upon PHOEBE’s (PHysics Of Eclipsing BinariEs) capabilities in a virtual reality (VR) environment to create an immersive and interactive experience for users. The application used is Vizard, a python-scripted VR development platform for environments such as Cave Automatic Virtual Environment (CAVE) and other off-the-shelf VR headsets. Vizard allows the freedom for all modeling to be precompiled without compromising functionality or usage on its part. The system requires five arguments to be precomputed using PHOEBE’s python front-end: the effective temperature, flux, relative intensity, vertex coordinates, and orbits; the user can opt to implement other features from PHOEBE to be accessed within the simulation as well. Here we present the method for making the data observables accessible in real time. An Occulus Rift will be available for a live showcase of various cases of VR rendering of PHOEBE binary systems including detached and contact binary stars.

The SCEC Broadband Platform: A Collaborative Open-Source Software Package for Strong Ground Motion Simulation and Validation

NASA Astrophysics Data System (ADS)

Silva, F.; Maechling, P. J.; Goulet, C. A.; Somerville, P.; Jordan, T. H.

2014-12-01

The Southern California Earthquake Center (SCEC) Broadband Platform is a collaborative software development project involving geoscientists, earthquake engineers, graduate students, and the SCEC Community Modeling Environment. The SCEC Broadband Platform (BBP) is open-source scientific software that can generate broadband (0-100Hz) ground motions for earthquakes, integrating complex scientific modules that implement rupture generation, low and high-frequency seismogram synthesis, non-linear site effects calculation, and visualization into a software system that supports easy on-demand computation of seismograms. The Broadband Platform operates in two primary modes: validation simulations and scenario simulations. In validation mode, the Platform runs earthquake rupture and wave propagation modeling software to calculate seismograms for a well-observed historical earthquake. Then, the BBP calculates a number of goodness of fit measurements that quantify how well the model-based broadband seismograms match the observed seismograms for a certain event. Based on these results, the Platform can be used to tune and validate different numerical modeling techniques. In scenario mode, the Broadband Platform can run simulations for hypothetical (scenario) earthquakes. In this mode, users input an earthquake description, a list of station names and locations, and a 1D velocity model for their region of interest, and the Broadband Platform software then calculates ground motions for the specified stations. Working in close collaboration with scientists and research engineers, the SCEC software development group continues to add new capabilities to the Broadband Platform and to release new versions as open-source scientific software distributions that can be compiled and run on many Linux computer systems. Our latest release includes 5 simulation methods, 7 simulation regions covering California, Japan, and Eastern North America, the ability to compare simulation results

Developing a PLC-friendly state machine model: lessons learned

NASA Astrophysics Data System (ADS)

Pessemier, Wim; Deconinck, Geert; Raskin, Gert; Saey, Philippe; Van Winckel, Hans

2014-07-01

Modern Programmable Logic Controllers (PLCs) have become an attractive platform for controlling real-time aspects of astronomical telescopes and instruments due to their increased versatility, performance and standardization. Likewise, vendor-neutral middleware technologies such as OPC Unified Architecture (OPC UA) have recently demonstrated that they can greatly facilitate the integration of these industrial platforms into the overall control system. Many practical questions arise, however, when building multi-tiered control systems that consist of PLCs for low level control, and conventional software and platforms for higher level control. How should the PLC software be structured, so that it can rely on well-known programming paradigms on the one hand, and be mapped to a well-organized OPC UA interface on the other hand? Which programming languages of the IEC 61131-3 standard closely match the problem domains of the abstraction levels within this structure? How can the recent additions to the standard (such as the support for namespaces and object-oriented extensions) facilitate a model based development approach? To what degree can our applications already take advantage of the more advanced parts of the OPC UA standard, such as the high expressiveness of the semantic modeling language that it defines, or the support for events, aggregation of data, automatic discovery, ... ? What are the timing and concurrency problems to be expected for the higher level tiers of the control system due to the cyclic execution of control and communication tasks by the PLCs? We try to answer these questions by demonstrating a semantic state machine model that can readily be implemented using IEC 61131 and OPC UA. One that does not aim to capture all possible states of a system, but rather one that attempts to organize the course-grained structure and behaviour of a system. In this paper we focus on the intricacies of this seemingly simple task, and on the lessons that we

Large communications platforms versus smaller satellites

NASA Technical Reports Server (NTRS)

1979-01-01

Communications systems using large platforms are compared with systems using conventional satellites. Systems models were generated and compared for U.S. domestic application and for 1 INTELSAT's international and domestic transponder lease application. Technology advances were assumed the platforms and the evolution of conventional satellites.

Massively Parallel, Molecular Analysis Platform Developed Using a CMOS Integrated Circuit With Biological Nanopores

PubMed Central

Roever, Stefan

2012-01-01

A massively parallel, low cost molecular analysis platform will dramatically change the nature of protein, molecular and genomics research, DNA sequencing, and ultimately, molecular diagnostics. An integrated circuit (IC) with 264 sensors was fabricated using standard CMOS semiconductor processing technology. Each of these sensors is individually controlled with precision analog circuitry and is capable of single molecule measurements. Under electronic and software control, the IC was used to demonstrate the feasibility of creating and detecting lipid bilayers and biological nanopores using wild type α-hemolysin. The ability to dynamically create bilayers over each of the sensors will greatly accelerate pore development and pore mutation analysis. In addition, the noise performance of the IC was measured to be 30fA(rms). With this noise performance, single base detection of DNA was demonstrated using α-hemolysin. The data shows that a single molecule, electrical detection platform using biological nanopores can be operationalized and can ultimately scale to millions of sensors. Such a massively parallel platform will revolutionize molecular analysis and will completely change the field of molecular diagnostics in the future.

Modelling and control of Base Plate Loading subsystem for The Motorized Adjustable Vertical Platform

NASA Astrophysics Data System (ADS)

Norsahperi, N. M. H.; Ahmad, S.; Fuad, A. F. M.; Mahmood, I. A.; Toha, S. F.; Akmeliawati, R.; Darsivan, F. J.

2017-03-01

Malaysia National Space Agency, ANGKASA is an organization that intensively undergoes many researches especially on space. On 2011, ANGKASA had built Satellite Assembly, Integration and Test Centre (AITC) for spacecraft development and test. Satellite will undergo numerous tests and one of it is Thermal test in Thermal Vacuum Chamber (TVC). In fact, TVC is located in cleanroom and on a platform. The only available facilities for loading and unloading the satellite is overhead crane. By utilizing the overhead crane can jeopardize the safety of the satellite. Therefore, Motorized vertical platform (MAVeP) for transferring the satellite into the TVC with capability to operate under cleanroom condition and limited space is proposed to facilitate the test. MAVeP is the combination of several mechanisms to produce horizontal and vertical motions with the ability to transfer the satellite from loading bay into TVC. The integration of both motions to elevate and transfer heavy loads with high precision capability will deliver major contributions in various industries such as aerospace and automotive. Base plate subsystem is capable to translate the horizontal motion by converting the angular motion from motor to linear motion by using rack and pinion mechanism. Generally a system can be modelled by performing physical modelling from schematic diagram or through system identification techniques. Both techniques are time consuming and required comprehensive understanding about the system, which may expose to error prone especially for complex mechanism. Therefore, a 3D virtual modelling technique has been implemented to represent the system in real world environment i.e. gravity to simulate control performance. The main purpose of this technique is to provide better model to analyse the system performance and capable to evaluate the dynamic behaviour of the system with visualization of the system performance, where a 3D prototype was designed and assembled in Solidworks

The Status of Spacecraft Bus and Platform Technology Development Under the NASA ISPT Program

NASA Technical Reports Server (NTRS)

Anderson, David; Munk, Michelle M.; Pencil, Eric; Dankanich, John; Glaab, Louis; Peterson, Todd

2014-01-01

The In-Space Propulsion Technology (ISPT) program is developing spacecraft bus and platform technologies that will enable or enhance NASA robotic science missions. The ISPT program is currently developing technology in three areas that include Propulsion System Technologies, Entry Vehicle Technologies, and Systems Mission Analysis. ISPTs propulsion technologies include: 1) NASAs Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6-7 kW throttle-able gridded ion system; 2) a Hall-effect electric propulsion (HEP) system for sample return and low cost missions; 3) the Advanced Xenon Flow Control System (AXFS); ultra-lightweight propellant tank technologies (ULTT); and propulsion technologies for a Mars Ascent Vehicle (MAV). The AXFS and ULTT are two component technologies being developed with nearer-term flight infusion in mind, whereas NEXT and the HEP are being developed as EP systems. ISPTs entry vehicle technologies are: 1) Aerocapture technology development with investments in a family of thermal protection system (TPS) materials and structures; guidance, navigation, and control (GNC) models of blunt-body rigid aeroshells; and aerothermal effect models; and 2) Multi-mission technologies for Earth Entry Vehicles (MMEEV) for sample return missions. The Systems Mission Analysis area is focused on developing tools and assessing the application of propulsion, entry vehicle, and spacecraft bus technologies to a wide variety of mission concepts. Several of the ISPT technologies are related to sample return missions and other spacecraft bus technology needs like: MAV propulsion, MMEEV, and electric propulsion. These technologies, as well as Aerocapture, are more vehicle and mission-focused, and present a different set of technology development challenges. These in-space propulsion technologies are applicable, and potentially enabling for future NASA Discovery, New Frontiers, Flagship and sample return missions currently under consideration. This paper provides

Geosynchronous platform definition study. Volume 4, Part 1: Traffic analysis and system requirements for the baseline traffic model

NASA Technical Reports Server (NTRS)

1973-01-01

The traffic analyses and system requirements data generated in the study resulted in the development of two traffic models; the baseline traffic model and the new traffic model. The baseline traffic model provides traceability between the numbers and types of geosynchronous missions considered in the study and the entire spectrum of missions foreseen in the total national space program. The information presented pertaining to the baseline traffic model includes: (1) definition of the baseline traffic model, including identification of specific geosynchronous missions and their payload delivery schedules through 1990; (2) Satellite location criteria, including the resulting distribution of the satellite population; (3) Geosynchronous orbit saturation analyses, including the effects of satellite physical proximity and potential electromagnetic interference; and (4) Platform system requirements analyses, including satellite and mission equipment descriptions, the options and limitations in grouping satellites, and on-orbit servicing criteria (both remotely controlled and man-attended).

Spaceflight Nutrition Research: Platforms and Analogs

NASA Technical Reports Server (NTRS)

Smith, Scott M.; Uchakin, Peter N.; Tobin, Brian W.

2002-01-01

Understanding human adaptation to weightlessness requires research in either the true microgravity environment or iii a ground-based model. Over the years, many flight platforms have been available, and many ground models have emerged for both human and animal studies of the effects of spaceflight on physiology. In this review, we provide a brief description of these models and the main points to be considered when choosing a model. We do not intend to provide a comprehensive overview of each platform or model, but rather to provide the reader with an overview of the options available for space nutrition research, and the relative merits and/or drawbacks of each.

Cloud Based Earth Observation Data Exploitation Platforms

NASA Astrophysics Data System (ADS)

Romeo, A.; Pinto, S.; Loekken, S.; Marin, A.

2017-12-01

In the last few years data produced daily by several private and public Earth Observation (EO) satellites reached the order of tens of Terabytes, representing for scientists and commercial application developers both a big opportunity for their exploitation and a challenge for their management. New IT technologies, such as Big Data and cloud computing, enable the creation of web-accessible data exploitation platforms, which offer to scientists and application developers the means to access and use EO data in a quick and cost effective way. RHEA Group is particularly active in this sector, supporting the European Space Agency (ESA) in the Exploitation Platforms (EP) initiative, developing technology to build multi cloud platforms for the processing and analysis of Earth Observation data, and collaborating with larger European initiatives such as the European Plate Observing System (EPOS) and the European Open Science Cloud (EOSC). An EP is a virtual workspace, providing a user community with access to (i) large volume of data, (ii) algorithm development and integration environment, (iii) processing software and services (e.g. toolboxes, visualization routines), (iv) computing resources, (v) collaboration tools (e.g. forums, wiki, etc.). When an EP is dedicated to a specific Theme, it becomes a Thematic Exploitation Platform (TEP). Currently, ESA has seven TEPs in a pre-operational phase dedicated to geo-hazards monitoring and prevention, costal zones, forestry areas, hydrology, polar regions, urban areas and food security. On the technology development side, solutions like the multi cloud EO data processing platform provides the technology to integrate ICT resources and EO data from different vendors in a single platform. In particular it offers (i) Multi-cloud data discovery, (ii) Multi-cloud data management and access and (iii) Multi-cloud application deployment. This platform has been demonstrated with the EGI Federated Cloud, Innovation Platform Testbed Poland

The Prodiguer Messaging Platform

NASA Astrophysics Data System (ADS)

Denvil, S.; Greenslade, M. A.; Carenton, N.; Levavasseur, G.; Raciazek, J.

2015-12-01

CONVERGENCE is a French multi-partner national project designed to gather HPC and informatics expertise to innovate in the context of running French global climate models with differing grids and at differing resolutions. Efficient and reliable execution of these models and the management and dissemination of model output are some of the complexities that CONVERGENCE aims to resolve.At any one moment in time, researchers affiliated with the Institut Pierre Simon Laplace (IPSL) climate modeling group, are running hundreds of global climate simulations. These simulations execute upon a heterogeneous set of French High Performance Computing (HPC) environments. The IPSL's simulation execution runtime libIGCM (library for IPSL Global Climate Modeling group) has recently been enhanced so as to support hitherto impossible realtime use cases such as simulation monitoring, data publication, metrics collection, simulation control, visualizations … etc. At the core of this enhancement is Prodiguer: an AMQP (Advanced Message Queue Protocol) based event driven asynchronous distributed messaging platform. libIGCM now dispatches copious amounts of information, in the form of messages, to the platform for remote processing by Prodiguer software agents at IPSL servers in Paris. Such processing takes several forms: Persisting message content to database(s); Launching rollback jobs upon simulation failure; Notifying downstream applications; Automation of visualization pipelines; We will describe and/or demonstrate the platform's: Technical implementation; Inherent ease of scalability; Inherent adaptiveness in respect to supervising simulations; Web portal receiving simulation notifications in realtime.

A Common DPU Platform for ESA JUICE Mission Instruments

NASA Astrophysics Data System (ADS)

Aberg, Martin; Hellstrom, Daniel; Samuelsson, Arne; Torelli, Felice

2016-08-01

This paper describes the resulting hardware and software platform based on GR712RC [1] LEON3-FT that Cobham Gaisler developed in accordance with the common system requirements of the ten scientific instruments on-board the ESA JUICE spacecraft destined the Jupiter system [8].The radiation hardened DPU platform features EDAC protected boot, application memory and working memory of configurable sizes and SpaceWire, FPGA I/O-32/16/8, GPIO, UART and SPI I/O interfaces. The design has undergone PSA, Risk, WCA, Radiation analyses etc. to justify component and design choices resulting in a robust design that can be used in spacecrafts requiring a total dose up to 100krad(Si). The prototype board manufactured uses engineering models of the flight components to ensure that development is representative.Validated boot, standby and driver software accommodates the various DPU platform configurations. The boot performs low-level DPU initialization, standby handles OBC SpaceWire communication and finally the loading and executing of application images typically stored in the non-volatile application memory.

Constructing RBAC Based Security Model in u-Healthcare Service Platform

PubMed Central

Shin, Moon Sun; Jeon, Heung Seok; Ju, Yong Wan; Lee, Bum Ju; Jeong, Seon-Phil

2015-01-01

In today's era of aging society, people want to handle personal health care by themselves in everyday life. In particular, the evolution of medical and IT convergence technology and mobile smart devices has made it possible for people to gather information on their health status anytime and anywhere easily using biometric information acquisition devices. Healthcare information systems can contribute to the improvement of the nation's healthcare quality and the reduction of related cost. However, there are no perfect security models or mechanisms for healthcare service applications, and privacy information can therefore be leaked. In this paper, we examine security requirements related to privacy protection in u-healthcare service and propose an extended RBAC based security model. We propose and design u-healthcare service integration platform (u-HCSIP) applying RBAC security model. The proposed u-HCSIP performs four main functions: storing and exchanging personal health records (PHR), recommending meals and exercise, buying/selling private health information or experience, and managing personal health data using smart devices. PMID:25695104

Constructing RBAC based security model in u-healthcare service platform.

PubMed

Shin, Moon Sun; Jeon, Heung Seok; Ju, Yong Wan; Lee, Bum Ju; Jeong, Seon-Phil

2015-01-01

In today's era of aging society, people want to handle personal health care by themselves in everyday life. In particular, the evolution of medical and IT convergence technology and mobile smart devices has made it possible for people to gather information on their health status anytime and anywhere easily using biometric information acquisition devices. Healthcare information systems can contribute to the improvement of the nation's healthcare quality and the reduction of related cost. However, there are no perfect security models or mechanisms for healthcare service applications, and privacy information can therefore be leaked. In this paper, we examine security requirements related to privacy protection in u-healthcare service and propose an extended RBAC based security model. We propose and design u-healthcare service integration platform (u-HCSIP) applying RBAC security model. The proposed u-HCSIP performs four main functions: storing and exchanging personal health records (PHR), recommending meals and exercise, buying/selling private health information or experience, and managing personal health data using smart devices.

Model driven development of clinical information sytems using openEHR.

PubMed

Atalag, Koray; Yang, Hong Yul; Tempero, Ewan; Warren, Jim

2011-01-01

openEHR and the recent international standard (ISO 13606) defined a model driven software development methodology for health information systems. However there is little evidence in the literature describing implementation; especially for desktop clinical applications. This paper presents an implementation pathway using .Net/C# technology for Microsoft Windows desktop platforms. An endoscopy reporting application driven by openEHR Archetypes and Templates has been developed. A set of novel GUI directives has been defined and presented which guides the automatic graphical user interface generator to render widgets properly. We also reveal the development steps and important design decisions; from modelling to the final software product. This might provide guidance for other developers and form evidence required for the adoption of these standards for vendors and national programs alike.

Floor Plans Engine Removal Platform, Hold Down Arm Platform, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Floor Plans - Engine Removal Platform, Hold Down Arm Platform, Hydraulic Equipment Platforms, Isometric Cutaway of Engine Removal Platform, Isometric Cutaway of Hold Down Arm Platform, Isometric Cutaway of Hydraulic Platforms and Engine Support System Access - Marshall Space Flight Center, Saturn V S-IC Static Test Facility, West Test Area, Huntsville, Madison County, AL

Single-step affinity purification of enzyme biotherapeutics: a platform methodology for accelerated process development.

PubMed

Brower, Kevin P; Ryakala, Venkat K; Bird, Ryan; Godawat, Rahul; Riske, Frank J; Konstantinov, Konstantin; Warikoo, Veena; Gamble, Jean

2014-01-01

Downstream sample purification for quality attribute analysis is a significant bottleneck in process development for non-antibody biologics. Multi-step chromatography process train purifications are typically required prior to many critical analytical tests. This prerequisite leads to limited throughput, long lead times to obtain purified product, and significant resource requirements. In this work, immunoaffinity purification technology has been leveraged to achieve single-step affinity purification of two different enzyme biotherapeutics (Fabrazyme® [agalsidase beta] and Enzyme 2) with polyclonal and monoclonal antibodies, respectively, as ligands. Target molecules were rapidly isolated from cell culture harvest in sufficient purity to enable analysis of critical quality attributes (CQAs). Most importantly, this is the first study that demonstrates the application of predictive analytics techniques to predict critical quality attributes of a commercial biologic. The data obtained using the affinity columns were used to generate appropriate models to predict quality attributes that would be obtained after traditional multi-step purification trains. These models empower process development decision-making with drug substance-equivalent product quality information without generation of actual drug substance. Optimization was performed to ensure maximum target recovery and minimal target protein degradation. The methodologies developed for Fabrazyme were successfully reapplied for Enzyme 2, indicating platform opportunities. The impact of the technology is significant, including reductions in time and personnel requirements, rapid product purification, and substantially increased throughput. Applications are discussed, including upstream and downstream process development support to achieve the principles of Quality by Design (QbD) as well as integration with bioprocesses as a process analytical technology (PAT). © 2014 American Institute of Chemical Engineers.

[Development of multi-channels cardiac electrophysiological polygraph with LabVIEW as software platform and its clinical application].

PubMed

Fan, Shounian; Jiang, Yi; Jiang, Chenxi; Yang, Tianhe; Zhang, Chengyun; Liu, Junshi; Wu, Qiang; Zheng, Yaxi; Liu, Xiaoqiao

2004-10-01

Polygraph has become a necessary instrument in interventional cardiology and fundamental research of medicine up to the present. In this study, a LabView development system (DS) (developed by NI in U.S.) used as software platform, a DAQ data acquisition module and universal computer used as hardware platform, were creatively coupled with our self-made low noise multi-channels preamplifier to develop Multi-channels electrocardiograph. The device possessed the functions such as real time display of physiological process, digit highpass and lowpass, 50Hz filtered and gain adjustment, instant storing, random playback and printing, and process control stimulation. Besides, it was small-sized, economically practical and easy to operate. It could advance the spread of cardiac intervention treatment in hospitals.

EFEHR - the European Facilities for Earthquake Hazard and Risk: beyond the web-platform

NASA Astrophysics Data System (ADS)

Danciu, Laurentiu; Wiemer, Stefan; Haslinger, Florian; Kastli, Philipp; Giardini, Domenico

2017-04-01

European Facilities for Earthquake Hazard and Risk (EEFEHR) represents the sustainable community resource for seismic hazard and risk in Europe. The EFEHR web platform is the main gateway to access data, models and tools as well as provide expertise relevant for assessment of seismic hazard and risk. The main services (databases and web-platform) are hosted at ETH Zurich and operated by the Swiss Seismological Service (Schweizerischer Erdbebendienst SED). EFEHR web-portal (www.efehr.org) collects and displays (i) harmonized datasets necessary for hazard and risk modeling, e.g. seismic catalogues, fault compilations, site amplifications, vulnerabilities, inventories; (ii) extensive seismic hazard products, namely hazard curves, uniform hazard spectra and maps for national and regional assessments. (ii) standardized configuration files for re-computing the regional seismic hazard models; (iv) relevant documentation of harmonized datasets, models and web-services. Today, EFEHR distributes full output of the 2013 European Seismic Hazard Model, ESHM13, as developed within the SHARE project (http://www.share-eu.org/); the latest results of the 2014 Earthquake Model of the Middle East (EMME14), derived within the EMME Project (www.emme-gem.org); the 2001 Global Seismic Hazard Assessment Project (GSHAP) results and the 2015 updates of the Swiss Seismic Hazard. New datasets related to either seismic hazard or risk will be incorporated as they become available. We present the currents status of the EFEHR platform, with focus on the challenges, summaries of the up-to-date datasets, user experience and feedback, as well as the roadmap to future technological innovation beyond the web-platform development. We also show the new services foreseen to fully integrate with the seismological core services of European Plate Observing System (EPOS).

Wikipedia as a Platform for Impactful Learning: A New Course Model in Higher Education

ERIC Educational Resources Information Center

Sigalov, Shani Evenstein; Nachmias, Rafi

2017-01-01

In January 2014, 62 students graduated from the first for-credit course dedicated to Wikipedia. Learning focused on improved consumption of information, and collaborative construction of knowledge using the Wikipedia platform. This paper investigates the design and implementation of this course model, while highlighting the benefits and challenges…

Handclapping Songs: A Spontaneous Platform for Child Development among 5-10-Year-Old Children

ERIC Educational Resources Information Center

Brodsky, Warren; Sulkin, Idit

2011-01-01

The impact of music activity on children's motor and cognitive skills has been investigated with music learning, instrument lessons and classroom music. While none have employed natural utterances, singing games or playground/street songs, these musical experiences of childhood are acknowledged as a major platform for child development. The…

Automated Work Package: Initial Wireless Communication Platform Design, Development, and Evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Al Rashdan, Ahmad Yahya Mohammad; Agarwal, Vivek

The Department of Energy’s Light Water Reactor Sustainability Program is developing the scientific basis to ensure long-term reliability, productivity, safety, and security of the nuclear power industry in the United States. The Instrumentation, Information, and Control (II&C) pathway of the program aims to increase the role of advanced II&C technologies to achieve this objective. One of the pathway efforts at Idaho National Laboratory (INL) is to improve the work packages execution process by replacing the expensive, inefficient, bulky, complex, and error-prone paper-based work orders with automated work packages (AWPs). An AWP is an automated and dynamic presentation of the workmore » package designed to guide the user through the work process. It is loaded on a mobile device, such as a tablet, and is capable of communicating with plant equipment and systems to acquire plant and procedure states. The AWP replaces those functions where a computer is more efficient and reliable than a human. To enable the automatic acquisition of plant data, it is necessary to design and develop a prototype platform for data exchange between the field instruments and the AWP mobile devices. The development of the platform aims to reveal issues and solutions generalizable to large-scale implementation of a similar system. Topics such as bandwidth, robustness, response time, interference, and security are usually associated with wireless communication. These concerns, along with other requirements, are listed in an earlier INL report. Specifically, the targeted issues and performance aspects in this work are relevant to the communication infrastructure from the perspective of promptness, robustness, expandability, and interoperability with different technologies.« less

Development of a New Robotic Ankle Rehabilitation Platform for Hemiplegic Patients after Stroke

PubMed Central

Duan, Lihong

2018-01-01

A large amount of hemiplegic survivors are suffering from motor impairment. Ankle rehabilitation exercises act an important role in recovering patients' walking ability after stroke. Currently, patients mainly perform ankle exercise to reobtain range of motion (ROM) and strength of the ankle joint under a therapist's assistance by manual operation. However, therapists suffer from high work intensity, and most of the existed rehabilitation devices focus on ankle functional training and ignore the importance of neurological rehabilitation in the early hemiplegic stage. In this paper, a new robotic ankle rehabilitation platform (RARP) is proposed to assist patients in executing ankle exercise. The robotic platform consists of two three-DOF symmetric layer-stacking mechanisms, which can execute ankle internal/external rotation, dorsiflexion/plantarflexion, and inversion/eversion exercise while the rotation center of the distal zone of the robotic platform always coincides with patients' ankle pivot center. Three exercise modes including constant-speed exercise, constant torque-impedance exercise, and awareness exercise are developed to execute ankle training corresponding to different rehabilitation stages. Experiments corresponding to these three ankle exercise modes are performed, the result demonstrated that the RARP is capable of executing ankle rehabilitation, and the novel awareness exercise mode motivates patients to proactively participate in ankle training. PMID:29736231

Integrated Spintronic Platforms for Biomolecular Recognition Detection

NASA Astrophysics Data System (ADS)

Martins, V. C.; Cardoso, F. A.; Loureiro, J.; Mercier, M.; Germano, J.; Cardoso, S.; Ferreira, R.; Fonseca, L. P.; Sousa, L.; Piedade, M. S.; Freitas, P. P.

2008-06-01

This paper covers recent developments in magnetoresistive based biochip platforms fabricated at INESC-MN, and their application to the detection and quantification of pathogenic waterborn microorganisms in water samples for human consumption. Such platforms are intended to give response to the increasing concern related to microbial contaminated water sources. The presented results concern the development of biological active DNA chips and protein chips and the demonstration of the detection capability of the present platforms. Two platforms are described, one including spintronic sensors only (spin-valve based or magnetic tunnel junction based), and the other, a fully scalable platform where each probe site consists of a MTJ in series with a thin film diode (TFD). Two microfluidic systems are described, for cell separation and concentration, and finally, the read out and control integrated electronics are described, allowing the realization of bioassays with a portable point of care unit. The present platforms already allow the detection of complementary biomolecular target recognition with 1 pM concentration.

Construction of Multimodal Transport Information Platform

NASA Astrophysics Data System (ADS)

Wang, Ya; Cheng, Yu; Zhao, Zhi

2018-06-01

With the rapid development of economy, the volume of transportation in China is increasing, the opening process of the market is accelerating, the scale of enterprises is expanding, the service quality is being improved, and the container multimodal transport is developing continuously.The hardware infrastructure of container multimodal transport is improved obviously, but the network platform construction of multimodal transport is still insufficient.Taking Shandong region of China as an example, the present situation of container multimodal transport in Shandong area can no longer meet the requirement of rapid development of container, and the construction of network platform needs to be solved urgently. Therefore, this paper will briefly describe the conception of construction of multimodal transport network platform in Shandong area.In order to achieve the rapid development of multimodal transport.

Base resolution methylome profiling: considerations in platform selection, data preprocessing and analysis

PubMed Central

Sun, Zhifu; Cunningham, Julie; Slager, Susan; Kocher, Jean-Pierre

2015-01-01

Bisulfite treatment-based methylation microarray (mainly Illumina 450K Infinium array) and next-generation sequencing (reduced representation bisulfite sequencing, Agilent SureSelect Human Methyl-Seq, NimbleGen SeqCap Epi CpGiant or whole-genome bisulfite sequencing) are commonly used for base resolution DNA methylome research. Although multiple tools and methods have been developed and used for the data preprocessing and analysis, confusions remains for these platforms including how and whether the 450k array should be normalized; which platform should be used to better fit researchers’ needs; and which statistical models would be more appropriate for differential methylation analysis. This review presents the commonly used platforms and compares the pros and cons of each in methylome profiling. We then discuss approaches to study design, data normalization, bias correction and model selection for differentially methylated individual CpGs and regions. PMID:26366945

Use of Parallel Micro-Platform for the Simulation the Space Exploration

NASA Astrophysics Data System (ADS)

Velasco Herrera, Victor Manuel; Velasco Herrera, Graciela; Rosano, Felipe Lara; Rodriguez Lozano, Salvador; Lucero Roldan Serrato, Karen

The purpose of this work is to create a parallel micro-platform, that simulates the virtual movements of a space exploration in 3D. One of the innovations presented in this design consists of the application of a lever mechanism for the transmission of the movement. The development of such a robot is a challenging task very different of the industrial manipulators due to a totally different target system of requirements. This work presents the study and simulation, aided by computer, of the movement of this parallel manipulator. The development of this model has been developed using the platform of computer aided design Unigraphics, in which it was done the geometric modeled of each one of the components and end assembly (CAD), the generation of files for the computer aided manufacture (CAM) of each one of the pieces and the kinematics simulation of the system evaluating different driving schemes. We used the toolbox (MATLAB) of aerospace and create an adaptive control module to simulate the system.

Development of Static Balance Measurement and Correction Compound Platform for Single Blade of Controllable Pitch Propeller

NASA Astrophysics Data System (ADS)

Chao, Zhang; Shijie, Su; Yilin, Yang; Guofu, Wang; Chao, Wang

2017-11-01

Aiming at the static balance of the controllable pitch propeller (CPP), a high efficiency static balance method based on the double-layer structure of the measuring table and gantry robot is adopted to realize the integration of torque measurement and corrected polish for controllable pitch propeller blade. The control system was developed by Microsoft Visual Studio 2015, and a composite platform prototype was developed. Through this prototype, conduct an experiment on the complete process of torque measurement and corrected polish based on a 300kg class controllable pitch propeller blade. The results show that the composite platform can correct the static balance of blade with a correct, efficient and labor-saving operation, and can replace the traditional method on static balance of the blade.

Platform C South Arrival

NASA Image and Video Library

2016-08-05

The second section of the first half of the C-level work platforms, C South, for NASA’s Space Launch System (SLS) rocket was offloaded from a heavy transport truck in a staging area on the west side of the Vehicle Assembly Building (VAB) at the agency’s Kennedy Space Center in Florida. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to VAB High Bay 3 to support processing of the SLS and Orion spacecraft. A total of 10 levels of new platforms, 20 platform halves altogether, will surround the SLS rocket and Orion spacecraft and provide access for testing and processing.

Autonomous mobile platform with simultaneous localisation and mapping system for patrolling purposes

NASA Astrophysics Data System (ADS)

Mitka, Łukasz; Buratowski, Tomasz

2017-10-01

This work describes an autonomous mobile platform for supervision and surveillance purposes. The system can be adapted for mounting on different types of vehicles. The platform is based on a SLAM navigation system which performs a localization task. Sensor fusion including laser scanners, inertial measurement unit (IMU), odometry and GPS lets the system determine its position in a certain and precise way. The platform is able to create a 3D model of a supervised area and export it as a point cloud. The system can operate both inside and outside as the navigation algorithm is resistant to typical localization errors caused by wheel slippage or temporal GPS signal loss. The system is equipped with a path-planning module which allows operating in two modes. The first mode is for periodical observation of points in a selected area. The second mode is turned on in case of an alarm. When it is called, the platform moves with the fastest route to the place of the alert. The path planning is always performed online with use of the most current scans, therefore the platform is able to adjust its trajectory to the environment changes or obstacles that are in the motion. The control algorithms are developed under the Robot Operating System (ROS) since it comes with drivers for many devices used in robotics. Such a solution allows for extending the system with any type of sensor in order to incorporate its data into a created area model. Proposed appliance can be ported to other existing robotic platforms or used to develop a new platform dedicated to a specific kind of surveillance. The platform use cases are to patrol an area, such as airport or metro station, in search for dangerous substances or suspicious objects and in case of detection instantly inform security forces. Second use case is a tele-operation in hazardous area for an inspection purposes.

HydroShare: A Platform for Collaborative Data and Model Sharing in Hydrology

NASA Astrophysics Data System (ADS)

Tarboton, D. G.; Idaszak, R.; Horsburgh, J. S.; Ames, D. P.; Goodall, J. L.; Couch, A.; Hooper, R. P.; Dash, P. K.; Stealey, M.; Yi, H.; Bandaragoda, C.; Castronova, A. M.

2017-12-01

HydroShare is an online, collaboration system for sharing of hydrologic data, analytical tools, and models. It supports the sharing of and collaboration around "resources" which are defined by standardized content types for data formats and models commonly used in hydrology. With HydroShare you can: Share your data and models with colleagues; Manage who has access to the content that you share; Share, access, visualize and manipulate a broad set of hydrologic data types and models; Use the web services application programming interface (API) to program automated and client access; Publish data and models and obtain a citable digital object identifier (DOI); Aggregate your resources into collections; Discover and access data and models published by others; Use web apps to visualize, analyze and run models on data in HydroShare. This presentation will describe the functionality and architecture of HydroShare highlighting its use as a virtual environment supporting education and research. HydroShare has components that support: (1) resource storage, (2) resource exploration, and (3) web apps for actions on resources. The HydroShare data discovery, sharing and publishing functions as well as HydroShare web apps provide the capability to analyze data and execute models completely in the cloud (servers remote from the user) overcoming desktop platform limitations. The HydroShare GIS app provides a basic capability to visualize spatial data. The HydroShare JupyterHub Notebook app provides flexible and documentable execution of Python code snippets for analysis and modeling in a way that results can be shared among HydroShare users and groups to support research collaboration and education. We will discuss how these developments can be used to support different types of educational efforts in Hydrology where being completely web based is of value in an educational setting as students can all have access to the same functionality regardless of their computer.

Metaliteracy as Pedagogical Framework for Learner-Centered Design in Three MOOC Platforms: Connectivist, Coursera and Canvas

ERIC Educational Resources Information Center

O'Brien, Kelsey; Forte, Michele; Mackey, Thomas P.; Jacobson, Trudi E.

2017-01-01

This article examines metaliteracy as a pedagogical model that leverages the assets of MOOC platforms to enhance self-regulated and self-empowered learning. Between 2013 and 2015, a collaborative teaching team within the State University of New York (SUNY) developed three MOOCs on three different platforms--connectivist, Coursera and Canvas--to…

Programmable data collection platform study

NASA Technical Reports Server (NTRS)

1976-01-01

The results of a feasibility study incorporating microprocessors in data collection platforms in described. An introduction to microcomputer hardware and software concepts is provided. The influence of microprocessor technology on the design of programmable data collection platform hardware is discussed. A standard modular PDCP design capable of meeting the design goals is proposed, and the process of developing PDCP programs is examined. A description of design and construction of the UT PDCP development system is given.

Designing next-generation platforms for evaluating scientific output: what scientists can learn from the social web

PubMed Central

Yarkoni, Tal

2012-01-01

Traditional pre-publication peer review of scientific output is a slow, inefficient, and unreliable process. Efforts to replace or supplement traditional evaluation models with open evaluation platforms that leverage advances in information technology are slowly gaining traction, but remain in the early stages of design and implementation. Here I discuss a number of considerations relevant to the development of such platforms. I focus particular attention on three core elements that next-generation evaluation platforms should strive to emphasize, including (1) open and transparent access to accumulated evaluation data, (2) personalized and highly customizable performance metrics, and (3) appropriate short-term incentivization of the userbase. Because all of these elements have already been successfully implemented on a large scale in hundreds of existing social web applications, I argue that development of new scientific evaluation platforms should proceed largely by adapting existing techniques rather than engineering entirely new evaluation mechanisms. Successful implementation of open evaluation platforms has the potential to substantially advance both the pace and the quality of scientific publication and evaluation, and the scientific community has a vested interest in shifting toward such models as soon as possible. PMID:23060783

Risk Management of P2P Internet Financing Service Platform

NASA Astrophysics Data System (ADS)

Yalei, Li

2017-09-01

Since 2005, the world’s first P2P Internet financing service platform Zopa in UK was introduced, in the development of “Internet +” trend, P2P Internet financing service platform has been developed rapidly. In 2007, China’s first P2P platform “filming loan” was established, marking the P2P Internet financing service platform to enter China and the rapid development. At the same time, China’s P2P Internet financing service platform also appeared in different forms of risk. This paper focuses on the analysis of the causes of risk of P2P Internet financing service platform and the performance of risk management process. It provides a solution to the Internet risk management plan, and explains the risk management system of the whole P2P Internet financing service platform and the future development direction.

ScaMo: Realisation of an OO-functional DSL for cross platform mobile applications development

NASA Astrophysics Data System (ADS)

Macos, Dragan; Solymosi, Andreas

2013-10-01

The software market is dynamically changing: the Internet is going mobile, the software applications are shifting from the desktop hardware onto the mobile devices. The largest markets are the mobile applications for iOS, Android and Windows Phone and for the purpose the typical programming languages include Objective-C, Java and C ♯. The realization of the native applications implies the integration of the developed software into the environments of mentioned mobile operating systems to enable the access to different hardware components of the devices: GPS module, display, GSM module, etc. This paper deals with the definition and possible implementation of an environment for the automatic application generation for multiple mobile platforms. It is based on a DSL for mobile application development, which includes the programming language Scala and a DSL defined in Scala. As part of a multi-stage cross-compiling algorithm, this language is translated into the language of the affected mobile platform. The advantage of our method lies in the expressiveness of the defined language and the transparent source code translation between different languages, which implies, for example, the advantages of debugging and development of the generated code.

BATMAV: a 2-DOF bio-inspired flapping flight platform

NASA Astrophysics Data System (ADS)

Bunget, Gheorghe; Seelecke, Stefan

2010-04-01

Due to the availability of small sensors, Micro-Aerial Vehicles (MAVs) can be used for detection missions of biological, chemical and nuclear agents. Traditionally these devices used fixed or rotary wings, actuated with electric DC motortransmission, a system which brings the disadvantage of a heavier platform. The overall objective of the BATMAV project is to develop a biologically inspired bat-like MAV with flexible and foldable wings for flapping flight. This paper presents a flight platform that features bat-inspired wings which are able to actively fold their elbow joints. A previous analysis of the flight physics for small birds, bats and large insects, revealed that the mammalian flight anatomy represents a suitable flight platform that can be actuated efficiently using Shape Memory Alloy (SMA) artificial-muscles. A previous study of the flight styles in bats based on the data collected by Norberg [1] helped to identify the required joint angles as relevant degrees of freedom for wing actuation. Using the engineering theory of robotic manipulators, engineering kinematic models of wings with 2 and 3-DOFs were designed to mimic the wing trajectories of the natural flier Plecotus auritus. Solid models of the bat-like skeleton were designed based on the linear and angular dimensions resulted from the kinematic models. This structure of the flight platform was fabricated using rapid prototyping technologies and assembled to form a desktop prototype with 2-DOFs wings. Preliminary flapping test showed suitable trajectories for wrist and wingtip that mimic the flapping cycle of the natural flyer.

Advanced propulsion for LEO and GEO platforms

NASA Technical Reports Server (NTRS)

Sovey, James S.; Pidgeon, David J.

1990-01-01

Mission requirements and mass savings applicable to specific low earth orbit and geostationary earth orbit platforms using three highly developed propulsion systems are described. Advanced hypergolic bipropellant thrusters and hydrazine arcjets can provide about 11 percent additional instrument payload to 14,000 kg LEO platforms. By using electric propulsion on a 8,000 kg class GEO platform, mass savings in excess of 15 percent of the beginning-of-life platform mass are obtained. Effects of large, advanced technology solar arrays and antennas on platform propulsion requirements are also discussed.

Development of a chemically defined platform fed-batch culture media for monoclonal antibody-producing CHO cell lines with optimized choline content.

PubMed

Kuwae, Shinobu; Miyakawa, Ichiko; Doi, Tomohiro

2018-01-11

A chemically defined platform basal medium and feed media were developed using a single Chinese hamster ovary (CHO) cell line that produces a monoclonal antibody (mAb). Cell line A, which showed a peak viable cell density of 5.9 × 10 6  cells/mL and a final mAb titer of 0.5 g/L in batch culture, was selected for the platform media development. Stoichiometrically balanced feed media were developed using glucose as an indicator of cell metabolism to determine the feed rates of all other nutrients. A fed-batch culture of cell line A using the platform fed-batch medium yielded a 6.4 g/L mAb titer, which was 12-fold higher than that of the batch culture. To examine the applicability of the platform basal medium and feed media, three other cell lines (A16, B, and C) that produce mAbs were cultured using the platform fed-batch medium, and they yielded mAb titers of 8.4, 3.3, and 6.2 g/L, respectively. The peak viable cell densities of the three cell lines ranged from 1.3 × 10 7 to 1.8 × 10 7  cells/mL. These results show that the nutritionally balanced fed-batch medium and feeds worked well for other cell lines. During the medium development, we found that choline limitation caused a lower cell viability, a lower mAb titer, a higher mAb aggregate content, and a higher mannose-5 content. The optimal choline chloride to glucose ratio for the CHO cell fed-batch culture was determined. Our platform basal medium and feed media will shorten the medium-development time for mAb-producing cell lines.

3D stratigraphic forward modelling of Shu'aiba Platform stratigraphy in the Bu Hasa Field, Abu Dhabi, United Arab Emirates.

NASA Astrophysics Data System (ADS)

Hu, J.; Lokier, S. W.

2012-04-01

This paper presents the results of three dimensional sequence stratigraphic forward modelling of the Aptian age Shu'aiba Formation from Abu Dhabi, United Arab Emirates (UAE). The Shu'aiba Formation lies within the uppermost part of the Lower Cretaceous Thamama Group and forms one of the most prolific hydrocarbon reservoir intervals of the Middle East with production dating back to the 1960's. The Shu'aiba Formation developed as a series of laterally-extensive shallow-water carbonate platforms in an epeiric sea that extended over the northern margin of the African-Arabian Plate. This shallow sea was bounded by the Arabian Shield to the west and the passive margin with the Neo-Tethys Ocean towards the north and east (Droste, 2010). The exposed Arabian Shield acted as a source of siliciclastic sediments to westernmost regions, however, more offshore areas were dominated by shallow-water carbonate deposition. Carbonate production was variously dominated by Lithocodium-Baccinella, orbitolinid foraminifera and rudist bivalves depending on local conditions. While there have been numerous studies of this important stratigraphic interval (for examples see van Buchem et al., 2010), there has been little attempt to simulate the sequence stratigraphic development of the formation. During the present study modelling was undertaken utilising the CARBONATE-3D stratigraphic forward modelling software (Warrlich et al., 2008; Warrlich et al., 2002)) thus allowing for the control of a diverse range of internal and external parameters on carbonate sequence development. This study focuses on platform development in the onshore Bu Hasa Field - the first giant oilfield to produce from the Shu'aiba Formation in Abu Dhabi. The carbonates of the Bu Hasa field were deposited on the southwest slope of the intra-shelf Bab Basin, siliciclastic content is minor. Initially these carbonates were algal dominated with rudist mounds becoming increasingly important over time (Alsharhan, 1987

LWAs computational platform for e-consultation using mobile devices: cases from developing nations.

PubMed

Olajubu, Emmanuel Ajayi; Odukoya, Oluwatoyin Helen; Akinboro, Solomon Adegbenro

2014-01-01

Mobile devices have been impacting on human standard of living by providing timely and accurate information anywhere and anytime through wireless media in developing nations. Shortage of experts in medical fields is very obvious throughout the whole world but more pronounced in developing nations. Thus, this study proposes a telemedicine platform for the vulnerable areas of developing nations. The vulnerable area are the interior with little or no medical facilities, hence the dwellers are very susceptible to sicknesses and diseases. The framework uses mobile devices that can run LightWeight Agents (LWAs) to send consultation requests to a remote medical expert in urban city from the vulnerable interiors. The feedback is conveyed to the requester through the same medium. The system architecture which contained AgenRoller, LWAs, The front-end (mobile devices) and back-end (the medical server) is presented. The algorithm for the software component of the architecture (AgenRoller) is also presented. The system is modeled as M/M/1/c queuing system, and simulated using Simevents from MATLAB Simulink environment. The simulation result presented show the average queue length, the number of entities in the queue and the number of entities departure from the system. These together present the rate of information processing in the system. A full scale development of this system with proper implementation will help extend the few medical facilities available in the urban cities in developing nations to the interiors thereby reducing the number of casualties in the vulnerable areas of the developing world especially in Sub Saharan Africa.

SU-E-J-44: Design a Platform and Phantom Model for Photoacoustic Imaging in Combination with CT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sick, J; Alsanea, F; Rancilio, N

2014-06-01

Purpose: Our (long-term) objective is to develop a US manipulator that will provide in situ radiation response and image-guided therapy for bladder cancer based on photoacoustic molecular imaging. Methods: A platform was devised to provide a reproducible positional frame of reference for targeting anatomic structure between MDCT and US scans, in lieu of CBCT, and to fuse photoacoustic molecular imaging. US and photoacoustic scans are taken of a patient while in the CT scanner and IRMT. Through co-registration, based on anatomical positions, we identified a common coordinate system to be used in Eclipse. A bladder phantom was constructed to validatemore » anatomical tracking via US and photoacoustic imaging. We tested the platform using phantom model to demonstrate validity once moved from the CT couch to the linear accelerator couch. Results: This platform interlocks with Varian exact couch index points for reproducibility of positioning. Construction from low Z material and sized appropriately to fit in CT/IMRT gantry. Error in conversion from cylindrical coordinates of the manipulator to X, Y, Z coordinates of the treatment couch was less than 1mm. We measured the bladder size in 3 different directions in both Eclipse from the CT and Acuson from US. The error was less than 2mm in all directions. CT and US images were co-registered in MATLAB. Co-registration of photoacoustic images is still being developed. Conclusion: For Linear Accelerators without on board imaging, MV portal images are not a viable option for the localization of soft tissue anatomy. We believe our manipulator provides an alternative using US imaging, which will be examined in an upcoming clinical trial. We plan to examine the value of hypoxia guided treatment through photoacoustic imaging during this trial.« less

EdREC: Design and Development of Adaptive Platform for Scaling-up Flipped Mastery Learning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gautam, Thakur

EdREC is an adaptive learning and management platform designed to enhance the adoption of differential classroom and mastery flipped learning in K-12 school system. The platform is an innovative approach to teaching and learning that addresses education needs of each student separately by providing customized education plans and adaptive learning methodologies that tunes to the students abilities as well as giving students freedom to learn in their own way. On one side, EdREC provides innovative ways to help students learn; on the other side, it reduces educators' workload and empowers them to understand their students better. EdREC comes with amore » state-of-the-art computer algorithm package that enables educators to store and retrieve their students' information and augment their abilities to individualize student attention, get real-time feedback about student education progress, and provide corrective actions. The platform provides approaches to design and develop a differential classroom concept that frees much needed time by the teachers to focus more on the students at the individual level and to increase communication and collaboration opportunities among them.« less

Rethinking In Vitro Embryo Culture: New Developments in Culture Platforms and Potential to Improve Assisted Reproductive Technologies1

PubMed Central

Smith, Gary D.; Takayama, Shuichi; Swain, Jason E.

2011-01-01

ABSTRACT The preponderance of research toward improving embryo development in vitro has focused on manipulation of the chemical soluble environment, including altering basic salt composition, energy substrate concentration, amino acid makeup, and the effect of various growth factors or addition or subtraction of other supplements. In contrast, relatively little work has been done examining the physical requirements of preimplantation embryos and the role culture platforms or devices can play in influencing embryo development within the laboratory. The goal of this review is not to reevaluate the soluble composition of past and current embryo culture media, but rather to consider how other controlled and precise factors such as time, space, mechanical interactions, gradient diffusions, cell movement, and surface interactions might influence embryo development. Novel culture platforms are being developed as a result of interdisciplinary collaborations between biologists and biomedical, material, chemical, and mechanical engineers. These approaches are looking beyond the soluble media composition and examining issues such as media volume and embryo spacing. Furthermore, methods that permit precise and regulated dynamic embryo culture with fluid flow and embryo movement are now available, and novel culture surfaces are being developed and tested. While several factors remain to be investigated to optimize the efficiency of embryo production, manipulation of the embryo culture microenvironment through novel devices and platforms may offer a pathway toward improving embryo development within the laboratory of the future. PMID:21998170

Development of deployable structures for large space platform systems, volume 1

NASA Technical Reports Server (NTRS)

1982-01-01

Generic deployable spacecraft configurations and deployable platform systems concepts were identified. Sizing, building block concepts, orbiter packaging, thermal analysis, cost analysis, and mass properties analysis as related to platform systems integration are considered. Technology needs are examined and the major criteria used in concept selection are delineated. Requirements for deployable habitat modules, tunnels, and OTV hangars are considered.

Coastal Surveillance Baseline Model Development

DTIC Science & Technology

2015-02-27

In the current STK model, a set of areas was defined for two reasons: To provide visual assistance during ship and aircraft route planning; and To...RF), electro-optic (EO), infrared (IR), and visual Partially Met The free version of STK can only generate simple generic sensors RQ-04 The model...25 APPENDIX A PLATFORM OBJECT ROUTE PLANNING PROCEDURE ............. A-1 APPENDIX B STK INSTALLATION

Design challenges in nanoparticle-based platforms: Implications for targeted drug delivery systems

NASA Astrophysics Data System (ADS)

Mullen, Douglas Gurnett

Characterization and control of heterogeneous distributions of nanoparticle-ligand components are major design challenges for nanoparticle-based platforms. This dissertation begins with an examination of poly(amidoamine) (PAMAM) dendrimer-based targeted delivery platform. A folic acid targeted modular platform was developed to target human epithelial cancer cells. Although active targeting was observed in vitro, active targeting was not found in vivo using a mouse tumor model. A major flaw of this platform design was that it did not provide for characterization or control of the component distribution. Motivated by the problems experienced with the modular design, the actual composition of nanoparticle-ligand distributions were examined using a model dendrimer-ligand system. High Pressure Liquid Chromatography (HPLC) resolved the distribution of components in samples with mean ligand/dendrimer ratios ranging from 0.4 to 13. A peak fitting analysis enabled the quantification of the component distribution. Quantified distributions were found to be significantly more heterogeneous than commonly expected and standard analytical parameters, namely the mean ligand/nanoparticle ratio, failed to adequately represent the component heterogeneity. The distribution of components was also found to be sensitive to particle modifications that preceded the ligand conjugation. With the knowledge gained from this detailed distribution analysis, a new platform design was developed to provide a system with dramatically improved control over the number of components and with improved batch reproducibility. Using semi-preparative HPLC, individual dendrimer-ligand components were isolated. The isolated dendrimer with precise numbers of ligands were characterized by NMR and analytical HPLC. In total, nine different dendrimer-ligand components were obtained with degrees of purity ≥80%. This system has the potential to serve as a platform to which a precise number of functional molecules

Tissue constructs: platforms for basic research and drug discovery.

PubMed

Elson, Elliot L; Genin, Guy M

2016-02-06

The functions, form and mechanical properties of cells are inextricably linked to their extracellular environment. Cells from solid tissues change fundamentally when, isolated from this environment, they are cultured on rigid two-dimensional substrata. These changes limit the significance of mechanical measurements on cells in two-dimensional culture and motivate the development of constructs with cells embedded in three-dimensional matrices that mimic the natural tissue. While measurements of cell mechanics are difficult in natural tissues, they have proven effective in engineered tissue constructs, especially constructs that emphasize specific cell types and their functions, e.g. engineered heart tissues. Tissue constructs developed as models of disease also have been useful as platforms for drug discovery. Underlying the use of tissue constructs as platforms for basic research and drug discovery is integration of multiscale biomaterials measurement and computational modelling to dissect the distinguishable mechanical responses separately of cells and extracellular matrix from measurements on tissue constructs and to quantify the effects of drug treatment on these responses. These methods and their application are the main subjects of this review.

Tissue constructs: platforms for basic research and drug discovery

PubMed Central

Elson, Elliot L.; Genin, Guy M.

2016-01-01

The functions, form and mechanical properties of cells are inextricably linked to their extracellular environment. Cells from solid tissues change fundamentally when, isolated from this environment, they are cultured on rigid two-dimensional substrata. These changes limit the significance of mechanical measurements on cells in two-dimensional culture and motivate the development of constructs with cells embedded in three-dimensional matrices that mimic the natural tissue. While measurements of cell mechanics are difficult in natural tissues, they have proven effective in engineered tissue constructs, especially constructs that emphasize specific cell types and their functions, e.g. engineered heart tissues. Tissue constructs developed as models of disease also have been useful as platforms for drug discovery. Underlying the use of tissue constructs as platforms for basic research and drug discovery is integration of multiscale biomaterials measurement and computational modelling to dissect the distinguishable mechanical responses separately of cells and extracellular matrix from measurements on tissue constructs and to quantify the effects of drug treatment on these responses. These methods and their application are the main subjects of this review. PMID:26855763

Thiolene and SIFEL-based Microfluidic Platforms for Liquid-Liquid Extraction

PubMed Central

Goyal, Sachit; Desai, Amit V.; Lewis, Robert W.; Ranganathan, David R.; Li, Hairong; Zeng, Dexing; Reichert, David E.; Kenis, Paul J.A.

2014-01-01

Microfluidic platforms provide several advantages for liquid-liquid extraction (LLE) processes over conventional methods, for example with respect to lower consumption of solvents and enhanced extraction efficiencies due to the inherent shorter diffusional distances. Here, we report the development of polymer-based parallel-flow microfluidic platforms for LLE. To date, parallel-flow microfluidic platforms have predominantly been made out of silicon or glass due to their compatibility with most organic solvents used for LLE. Fabrication of silicon and glass-based LLE platforms typically requires extensive use of photolithography, plasma or laser-based etching, high temperature (anodic) bonding, and/or wet etching with KOH or HF solutions. In contrast, polymeric microfluidic platforms can be fabricated using less involved processes, typically photolithography in combination with replica molding, hot embossing, and/or bonding at much lower temperatures. Here we report the fabrication and testing of microfluidic LLE platforms comprised of thiolene or a perfluoropolyether-based material, SIFEL, where the choice of materials was mainly guided by the need for solvent compatibility and fabrication amenability. Suitable designs for polymer-based LLE platforms that maximize extraction efficiencies within the constraints of the fabrication methods and feasible operational conditions were obtained using analytical modeling. To optimize the performance of the polymer-based LLE platforms, we systematically studied the effect of surface functionalization and of microstructures on the stability of the liquid-liquid interface and on the ability to separate the phases. As demonstrative examples, we report (i) a thiolene-based platform to determine the lipophilicity of caffeine, and (ii) a SIFEL-based platform to extract radioactive copper from an acidic aqueous solution. PMID:25246730

Information Management Platform for Data Analytics and Aggregation (IMPALA) System Design Document

NASA Technical Reports Server (NTRS)

Carnell, Andrew; Akinyelu, Akinyele

2016-01-01

The System Design document tracks the design activities that are performed to guide the integration, installation, verification, and acceptance testing of the IMPALA Platform. The inputs to the design document are derived from the activities recorded in Tasks 1 through 6 of the Statement of Work (SOW), with the proposed technical solution being the completion of Phase 1-A. With the documentation of the architecture of the IMPALA Platform and the installation steps taken, the SDD will be a living document, capturing the details about capability enhancements and system improvements to the IMPALA Platform to provide users in development of accurate and precise analytical models. The IMPALA Platform infrastructure team, data architecture team, system integration team, security management team, project manager, NASA data scientists and users are the intended audience of this document. The IMPALA Platform is an assembly of commercial-off-the-shelf (COTS) products installed on an Apache-Hadoop platform. User interface details for the COTS products will be sourced from the COTS tools vendor documentation. The SDD is a focused explanation of the inputs, design steps, and projected outcomes of every design activity for the IMPALA Platform through installation and validation.

PADF RF localization experiments with multi-agent caged-MAV platforms

NASA Astrophysics Data System (ADS)

Barber, Christopher; Gates, Miguel; Selmic, Rastko; Al-Issa, Huthaifa; Ordonez, Raul; Mitra, Atindra

2011-06-01

This paper provides a summary of preliminary RF direction finding results generated within an AFOSR funded testbed facility recently developed at Louisiana Tech University. This facility, denoted as the Louisiana Tech University Micro- Aerial Vehicle/Wireless Sensor Network (MAVSeN) Laboratory, has recently acquired a number of state-of-the-art MAV platforms that enable us to analyze, design, and test some of our recent results in the area of multiplatform position-adaptive direction finding (PADF) [1] [2] for localization of RF emitters in challenging embedded multipath environments. Discussions within the segmented sections of this paper include a description of the MAVSeN Laboratory and the preliminary results from the implementation of mobile platforms with the PADF algorithm. This novel approach to multi-platform RF direction finding is based on the investigation of iterative path-loss based (i.e. path loss exponent) metrics estimates that are measured across multiple platforms in order to develop a control law that robotically/intelligently positionally adapt (i.e. self-adjust) the location of each distributed/cooperative platform. The body of this paper provides a summary of our recent results on PADF and includes a discussion on state-of-the-art Sensor Mote Technologies as applied towards the development of sensor-integrated caged-MAV platform for PADF applications. Also, a discussion of recent experimental results that incorporate sample approaches to real-time singleplatform data pruning is included as part of a discussion on potential approaches to refining a basic PADF technique in order to integrate and perform distributed self-sensitivity and self-consistency analysis as part of a PADF technique with distributed robotic/intelligent features. These techniques are extracted in analytical form from a parallel study denoted as "PADF RF Localization Criteria for Multi-Model Scattering Environments". The focus here is on developing and reporting specific

The VISPA Internet Platform for Students

NASA Astrophysics Data System (ADS)

Asseldonk, D. v.; Erdmann, M.; Fischer, R.; Glaser, C.; Müller, G.; Quast, T.; Rieger, M.; Urban, M.

2016-04-01

The VISPA internet platform enables users to remotely run Python scripts and view resulting plots or inspect their output data. With a standard web browser as the only user requirement on the client-side, the system becomes suitable for blended learning approaches for university physics students. VISPA was used in two consecutive years each by approx. 100 third year physics students at the RWTH Aachen University for their homework assignments. For example, in one exercise students gained a deeper understanding of Einsteins mass-energy relation by analyzing experimental data of electron-positron pairs revealing J / Ψ and Z particles. Because the students were free to choose their working hours, only few users accessed the platform simultaneously. The positive feedback from students and the stability of the platform lead to further development of the concept. This year, students accessed the platform in parallel while they analyzed the data recorded by demonstrated experiments live in the lecture hall. The platform is based on experience in the development of professional analysis tools. It combines core technologies from previous projects: an object-oriented C++ library, a modular data-driven analysis flow, and visual analysis steering. We present the platform and discuss its benefits in the context of teaching based on surveys that are conducted each semester.

Technology platform development for targeted plasma metabolites in human heart failure.

PubMed

Chan, Cy X'avia; Khan, Anjum A; Choi, Jh Howard; Ng, Cm Dominic; Cadeiras, Martin; Deng, Mario; Ping, Peipei

2013-01-01