Preliminary Axial Flow Turbine Design and Off-Design Performance Analysis Methods for Rotary Wing Aircraft Engines. Part 1; Validation

NASA Technical Reports Server (NTRS)

Chen, Shu-cheng, S.

2009-01-01

For the preliminary design and the off-design performance analysis of axial flow turbines, a pair of intermediate level-of-fidelity computer codes, TD2-2 (design; reference 1) and AXOD (off-design; reference 2), are being evaluated for use in turbine design and performance prediction of the modern high performance aircraft engines. TD2-2 employs a streamline curvature method for design, while AXOD approaches the flow analysis with an equal radius-height domain decomposition strategy. Both methods resolve only the flows in the annulus region while modeling the impact introduced by the blade rows. The mathematical formulations and derivations involved in both methods are documented in references 3, 4 for TD2-2) and in reference 5 (for AXOD). The focus of this paper is to discuss the fundamental issues of applicability and compatibility of the two codes as a pair of companion pieces, to perform preliminary design and off-design analysis for modern aircraft engine turbines. Two validation cases for the design and the off-design prediction using TD2-2 and AXOD conducted on two existing high efficiency turbines, developed and tested in the NASA/GE Energy Efficient Engine (GE-E3) Program, the High Pressure Turbine (HPT; two stages, air cooled) and the Low Pressure Turbine (LPT; five stages, un-cooled), are provided in support of the analysis and discussion presented in this paper.

Targeted prodrugs in oral drug delivery: the modern molecular biopharmaceutical approach.

PubMed

Dahan, Arik; Khamis, Mustafa; Agbaria, Riad; Karaman, Rafik

2012-08-01

The molecular revolution greatly impacted the field of drug design and delivery in general, and the utilization of the prodrug approach in particular. The increasing understanding of membrane transporters has promoted a novel 'targeted-prodrug' approach utilizing carrier-mediated transport to increase intestinal permeability, as well as specific enzymes to promote activation to the parent drug. This article provides the reader with a concise overview of this modern approach to prodrug design. Targeting the oligopeptide transporter PEPT1 for absorption and the serine hydrolase valacyclovirase for activation will be presented as examples for the successful utilization of this approach. Additionally, the use of computational approaches, such as DFT and ab initio molecular orbital methods, in modern prodrugs design will be discussed. Overall, in the coming years, more and more information will undoubtedly become available regarding intestinal transporters and potential enzymes that may be exploited for the targeted modern prodrug approach. Hence, the concept of prodrug design can no longer be viewed as merely a chemical modification to solve problems associated with parent compounds. Rather, it opens promising opportunities for precise and efficient drug delivery, as well as enhancement of treatment options and therapeutic efficacy.

A Modern Series Of Cinematographic Lenses: From Concept To Product

NASA Astrophysics Data System (ADS)

Neil, lain A.

1988-06-01

In the past photographic "taking" lenses and, in particular, those for the motion picture industry i.e. cinematographic lenses have had a mixed career due to inconsistencies between the processes of lens design, manufacture, testing and calibration and practical assessment in the customer domain. Usually these inconsistencies can be attributed to differences between the comparison of, a lens design "scientifically" made and final evaluation in an "artistic" manner. The following paper addresses the processes of lens design, manufacture, testing and calibration using a combination of acquired practical experience and modern test and calibration methods. Various performance aspects are separately addressed and considered in terms of different means of measurement.

Formal methods in computer system design

NASA Astrophysics Data System (ADS)

Hoare, C. A. R.

1989-12-01

This note expounds a philosophy of engineering design which is stimulated, guided and checked by mathematical calculations and proofs. Its application to software engineering promises the same benifits as those derived from the use of mathematics in all other branches of modern science.

Artificial intelligence in robot control systems

NASA Astrophysics Data System (ADS)

Korikov, A.

2018-05-01

This paper analyzes modern concepts of artificial intelligence and known definitions of the term "level of intelligence". In robotics artificial intelligence system is defined as a system that works intelligently and optimally. The author proposes to use optimization methods for the design of intelligent robot control systems. The article provides the formalization of problems of robotic control system design, as a class of extremum problems with constraints. Solving these problems is rather complicated due to the high dimensionality, polymodality and a priori uncertainty. Decomposition of the extremum problems according to the method, suggested by the author, allows reducing them into a sequence of simpler problems, that can be successfully solved by modern computing technology. Several possible approaches to solving such problems are considered in the article.

NLF technology is ready to go

NASA Technical Reports Server (NTRS)

Holmes, Bruce J.

1988-01-01

Natural laminar flow (NLF) can reduce drag on aircraft developed using modern structural design methods. Modern metal and composite construction methods can meet NLF requirements for subsonic commuter and business airframes. NLF research at NASA concentrates on expanding the practical application of NLF drag reduction technology; payoffs include progress with liquid-crystal flow visualization, NLF on three-dimensional bodies, and the effects of acoustics on laminar stability. Fuel savings from 2 to 4 percent are expected if laminar flow could be achieved over the forward 50 percent of engine nacelles on large transports depending on the configuration. It is concluded that the skill required to use NLF for drag reduction depends on understanding the conservative design corridors within which laminar flow is durable and reliable.

Femoral vessel injuries in modern warfare since Vietnam.

PubMed

Pearl, Jonathan P; McNally, Michael P; Perdue, Philip W

2003-09-01

The incidence of lower extremity injuries is high in modern warfare; however the mortality rate from these injuries is low. Despite the overall low mortality of lower extremity injuries, many deaths in modern conflicts are due to femoral vessel injury. The modern warfare literature was reviewed. In Somalia, 1 of the 14 reported deaths was due to a laceration of the superficial femoral artery. In the Persian Gulf, three deaths were reported in an Army field hospital, one resulted from uncontrolled hemorrhage from a profunda femoris artery wound and two others resulted from traumatic amputations with consequent major arterial injury. Despite the advances in modern body armor, the groin is left unprotected. A strategy to help minimize U.S. casualties in modern warfare may be a method of field hemostasis specifically designed for femoral vessel injury.

Human-Centred Design Projects and Co-Design in/outside the Turkish Classroom: Responses and Challenges

ERIC Educational Resources Information Center

Emmanouil, Marina

2015-01-01

Perhaps more than any other professional group in modern history, designers have felt compelled to undertake the responsibility of addressing and engaging with societal problems in their practice. Initially, this liability involved concerns of form and production methods during the industrial revolution era, and developed into existential, ethical…

Children as Community Planners: Report on an Environmental Design Project 1.

ERIC Educational Resources Information Center

Hanley, Gerard L.; And Others

1981-01-01

Describes a six-month project emphasizing participant-observation teaching strategy in which a third-grade class of 24 students employed methods of environmental design to design communities within a modern forest and more primitive tundra and desert regions. Discusses project goals, results, and implications for future use of environmental design…

The Effects of the Critical Ice Accretion on Airfoil and Wing Performance

NASA Technical Reports Server (NTRS)

Selig, Michael S.; Bragg, Michael B.; Saeed, Farooq

1998-01-01

In support of the NASA Lewis Modern Airfoils Ice Accretion Test Program, the University of Illinois at Urbana-Champaign provided expertise in airfoil design and aerodynamic analysis to determine the aerodynamic effect of ice accretion on modern airfoil sections. The effort has concentrated on establishing a design/testing methodology for "hybrid airfoils" or "sub-scale airfoils," that is, airfoils having a full-scale leading edge together with a specially designed and foreshortened aft section. The basic approach of using a full-scale leading edge with a foreshortened aft section was considered to a limited extent over 40 years ago. However, it was believed that the range of application of the method had not been fully exploited. Thus a systematic study was being undertaken to investigate and explore the range of application of the method so as to determine its overall potential.

Mobile device geo-localization and object visualization in sensor networks

NASA Astrophysics Data System (ADS)

Lemaire, Simon; Bodensteiner, Christoph; Arens, Michael

2014-10-01

In this paper we present a method to visualize geo-referenced objects on modern smartphones using a multi- functional application design. The application applies different localization and visualization methods including the smartphone camera image. The presented application copes well with different scenarios. A generic application work flow and augmented reality visualization techniques are described. The feasibility of the approach is experimentally validated using an online desktop selection application in a network with a modern of-the-shelf smartphone. Applications are widespread and include for instance crisis and disaster management or military applications.

Processes for manufacturing multifocal diffractive-refractive intraocular lenses

NASA Astrophysics Data System (ADS)

Iskakov, I. A.

2017-09-01

Manufacturing methods and design features of modern diffractive-refractive intraocular lenses are discussed. The implantation of multifocal intraocular lenses is the most optimal method of restoring the accommodative ability of the eye after removal of the natural lens. Diffractive-refractive intraocular lenses are the most widely used implantable multifocal lenses worldwide. Existing methods for manufacturing such lenses implement various design solutions to provide the best vision function after surgery. The wide variety of available diffractive-refractive intraocular lens designs reflects the demand for this method of vision correction in clinical practice and the importance of further applied research and development of new technologies for designing improved lens models.

Editorial: Mathematical Methods and Modeling in Machine Fault Diagnosis

DOE PAGES

Yan, Ruqiang; Chen, Xuefeng; Li, Weihua; ...

2014-12-18

Modern mathematics has commonly been utilized as an effective tool to model mechanical equipment so that their dynamic characteristics can be studied analytically. This will help identify potential failures of mechanical equipment by observing change in the equipment’s dynamic parameters. On the other hand, dynamic signals are also important and provide reliable information about the equipment’s working status. Modern mathematics has also provided us with a systematic way to design and implement various signal processing methods, which are used to analyze these dynamic signals, and to enhance intrinsic signal components that are directly related to machine failures. This special issuemore » is aimed at stimulating not only new insights on mathematical methods for modeling but also recently developed signal processing methods, such as sparse decomposition with potential applications in machine fault diagnosis. Finally, the papers included in this special issue provide a glimpse into some of the research and applications in the field of machine fault diagnosis through applications of the modern mathematical methods.« less

Discussion on Application of Space Materials and Technological Innovation in Dynamic Fashion Show

NASA Astrophysics Data System (ADS)

Huo, Meilin; Kim, Chul Soo; Zhao, Wenhan

2018-03-01

In modern dynamic fashion show, designers often use the latest ideas and technology, and spend their energy in stage effect and overall environment to make audience’s watching a fashion show like an audio-visual feast. With rapid development of China’s science and technology, it has become a design trend to strengthen the relationship between new ideas, new trends and technology in modern art. With emergence of new technology, new methods and new materials, designers for dynamic fashion show stage art can choose the materials with an increasingly large scope. Generation of new technology has also made designers constantly innovate the stage space design means, and made the stage space design innovated constantly on the original basis of experiences. The dynamic clothing display space is on design of clothing display space, layout, platform decoration style, platform models, performing colors, light arrangement, platform background, etc.

An Engineering Method of Civil Jet Requirements Validation Based on Requirements Project Principle

NASA Astrophysics Data System (ADS)

Wang, Yue; Gao, Dan; Mao, Xuming

2018-03-01

A method of requirements validation is developed and defined to meet the needs of civil jet requirements validation in product development. Based on requirements project principle, this method will not affect the conventional design elements, and can effectively connect the requirements with design. It realizes the modern civil jet development concept, which is “requirement is the origin, design is the basis”. So far, the method has been successfully applied in civil jet aircraft development in China. Taking takeoff field length as an example, the validation process and the validation method of the requirements are detailed introduced in the study, with the hope of providing the experiences to other civil jet product design.

Development and evaluation of a simplified superpave IDT testing system for implementation in mix design and control : final report, March 2008.

DOT National Transportation Integrated Search

2009-08-01

Asphalt mixtures designed using modern conventional methods, whether Marshall or Superpave methodologies, fail to address the cracking performance of these mixtures. Research previously conducted at the University of Florida for the Florida Departmen...

Occupant responses in conventional and ABTS seats in high-speed rear sled tests.

PubMed

Viano, David C; Parenteau, Chantal S; Burnett, Roger; Prasad, Priya

2018-01-02

This study compared biomechanical responses of a normally seated Hybrid III dummy on conventional and all belts to seat (ABTS) seats in 40.2 km/h (25 mph) rear sled tests. It determined the difference in performance with modern (≥2000 MY) seats compared to older (<2000 MY) seats and ABTS seats. The seats were fixed in a sled buck subjected to a 40.2 km/h (25 mph) rear sled test. The pulse was a 15 g double-peak acceleration with 150 ms duration. The 50th percentile Hybrid III was lap-shoulder belted in the FMVSS 208 design position. The testing included 11 <2000 MY, 8 ≥2000 MY, and 7 ABTS seats. The dummy was fully instrumented, including head accelerations, upper and lower neck 6-axis load cells, chest acceleration, thoracic and lumbar spine load cells, and pelvis accelerations. The peak responses were normalized by injury assessment reference values (IARVs) to assess injury risks. Statistical analysis was conducted using Student's t test. High-speed video documented occupant kinematics. Biomechanical responses were lower with modern (≥2000 MY) seats than older (<2000 MY) designs. The lower neck extension moment was 32.5 ± 9.7% of IARV in modern seats compared to 62.8 ± 31.6% in older seats (P =.01). Overall, there was a 34% reduction in the comparable biomechanical responses with modern seats. Biomechanical responses were lower with modern seats than ABTS seats. The lower neck extension moment was 41.4 ± 7.8% with all MY ABTS seats compared to 32.5 ± 9.7% in modern seats (P =.07). Overall, the ABTS seats had 13% higher biomechanical responses than the modern seats. Modern (≥2000 MY) design seats have lower biomechanical responses in 40.2 km/h rear sled tests than older (<2000 MY) designs and ABTS designs. The improved performance is consistent with an increase in seat strength combined with improved occupant kinematics through pocketing of the occupant into the seatback, higher and more forward head restraint, and other design changes. The methods and data presented here provide a basis for standardized testing of seats. However, a complete understanding of seat safety requires consideration of out-of-position (OOP) occupants in high-speed impacts and consideration of the much more common, low-speed rear impacts.

Challenges of Aircraft Design Integration

DTIC Science & Technology

2003-03-01

predicted by the conceptual stick model and the full FEM of the Challenger wing without winglets . Advanced aerodynamic wing design methods To design wings...Piperni, E. Laurendeau Advanced Aerodynamics Bombardier Aerospace 400 CMte Vertu Road Dorval, Quebec, Canada, H4S 1Y9 Fassi.Kafyeke @notes.canadair.ca Tel...514) 855-7186 Abstract The design of a modern airplane brings together many disciplines: structures, aerodynamics , controls, systems, propulsion

LIBRARY FACILITIES FOR ELEMENTARY AND SECONDARY SCHOOLS.

ERIC Educational Resources Information Center

Office of Education (DHEW), Washington, DC.

MODERN METHODS OF TEACHING REQUIRE INCREASED RESEARCH, INDEPENDENT STUDY, READING, LISTENING, AND VIEWING. NEW DESIGNS FOR LIBRARY FACILITIES ARE NECESSARY. SOME OF THE INNOVATIONS IN LIBRARY SERVICE AND DESIGN INCLUDE--THE USE OF CARRELS FOR INDIVIDUAL STUDY, PROVISION OF A LIBRARY CLASSROOM FOR USE IN TEACHING LIBRARY RESEARCH TECHNIQUES, A…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan, Ruqiang; Chen, Xuefeng; Li, Weihua

Modern mathematics has commonly been utilized as an effective tool to model mechanical equipment so that their dynamic characteristics can be studied analytically. This will help identify potential failures of mechanical equipment by observing change in the equipment’s dynamic parameters. On the other hand, dynamic signals are also important and provide reliable information about the equipment’s working status. Modern mathematics has also provided us with a systematic way to design and implement various signal processing methods, which are used to analyze these dynamic signals, and to enhance intrinsic signal components that are directly related to machine failures. This special issuemore » is aimed at stimulating not only new insights on mathematical methods for modeling but also recently developed signal processing methods, such as sparse decomposition with potential applications in machine fault diagnosis. Finally, the papers included in this special issue provide a glimpse into some of the research and applications in the field of machine fault diagnosis through applications of the modern mathematical methods.« less

The design of a turboshaft speed governor using modern control techniques

NASA Technical Reports Server (NTRS)

Delosreyes, G.; Gouchoe, D. R.

1986-01-01

The objectives of this program were: to verify the model of off schedule compressor variable geometry in the T700 turboshaft engine nonlinear model; to evaluate the use of the pseudo-random binary noise (PRBN) technique for obtaining engine frequency response data; and to design a high performance power turbine speed governor using modern control methods. Reduction of T700 engine test data generated at NASA-Lewis indicated that the off schedule variable geometry effects were accurate as modeled. Analysis also showed that the PRBN technique combined with the maximum likelihood model identification method produced a Bode frequency response that was as accurate as the response obtained from standard sinewave testing methods. The frequency response verified the accuracy of linear models consisting of engine partial derivatives and used for design. A power turbine governor was designed using the Linear Quadratic Regulator (LQR) method of full state feedback control. A Kalman filter observer was used to estimate helicopter main rotor blade velocity. Compared to the baseline T700 power turbine speed governor, the LQR governor reduced droop up to 25 percent for a 490 shaft horsepower transient in 0.1 sec simulating a wind gust, and up to 85 percent for a 700 shaft horsepower transient in 0.5 sec simulating a large collective pitch angle transient.

Terminal area automatic navigation, guidance and control research using the Microwave Landing System (MLS). Part 5: Design and development of a Digital Integrated Automatic Landing System (DIALS) for steep final approach using modern control techniques

NASA Technical Reports Server (NTRS)

Halyo, N.

1983-01-01

The design and development of a 3-D Digital Integrated Automatic Landing System (DIALS) for the Terminal Configured Vehicle (TCV) Research Aircraft, a B-737-100 is described. The system was designed using sampled data Linear Quadratic Gaussian (LOG) methods, resulting in a direct digital design with a modern control structure which consists of a Kalman filter followed by a control gain matrix, all operating at 10 Hz. DIALS uses Microwave Landing System (MLS) position, body-mounted accelerometers, as well as on-board sensors usually available on commercial aircraft, but does not use inertial platforms. The phases of the final approach considered are the localizer and glideslope capture which may be performed simultaneously, localizer and steep glideslope track or hold, crab/decrab and flare to touchdown. DIALS captures, tracks and flares from steep glideslopes ranging from 2.5 deg to 5.5 deg, selected prior to glideslope capture. Digital Integrated Automatic Landing System is the first modern control design automatic landing system successfully flight tested. The results of an initial nonlinear simulation are presented here.

Flight test results for the Digital Integrated Automatic Landing Systems (DIALS): A modern control full-state feedback design

NASA Technical Reports Server (NTRS)

Hueschen, R. M.

1984-01-01

The Digital Integrated Automatic Landing System (DIALS) is discussed. The DIALS is a modern control theory design performing all the maneuver modes associated with current autoland systems: localizer capture and track, glideslope capture and track, decrab, and flare. The DIALS is an integrated full-state feedback system which was designed using direct-digital methods. The DIALS uses standard aircraft sensors and the digital Microwave Landing System (MLS) signals as measurements. It consists of separately designed longitudinal and lateral channels although some cross-coupling variables are fed between channels for improved state estimates and trajectory commands. The DIALS was implemented within the 16-bit fixed-point flight computers of the ATOPS research aircraft, a small twin jet commercial transport outfitted with a second research cockpit and a fly-by-wire system. The DIALS became the first modern control theory design to be successfully flight tested on a commercial-type aircraft. Flight tests were conducted in late 1981 using a wide coverage MLS on Runway 22 at Wallops Flight Center. All the modes were exercised including the capture and track of steep glidescopes up to 5 degrees.

An evaluation of the transferability of Munsell's colour notation methodology to modern inkjet printing technology

NASA Astrophysics Data System (ADS)

Olen, Melissa; Geisow, Adrian; Parraman, Carinna

2015-01-01

This paper examines the transferability of the Munsell system to modern inkjet colorants and printing technology following a similar approach to his original methods. While extensive research and development has gone into establishing methods for measuring and modelling the modern colour gamut, this study seeks to reintegrate the psychophysical and artistic principles used in Munsell's early colour studies with digital print. Contemporary inkjet printing, with ink sets containing a greater number of primary colorants, are significantly higher in chroma compared to the limited colorants available at the time of Munsell's original work. Following Munsell's design and implementation, our experiments replicate the use of Clerk-Maxwell's spinning disks in order to examine the effects of colour mixing with these expanded colour capacities, and to determine hue distribution and placement. This work revisits Munsell's project in light of known issues, and formulates questions about how we can reintegrate Munsell's approach for colour description and mixing into modern colour science, understanding, and potential application.

The Role of Bioreactors in Ligament and Tendon Tissue Engineering.

PubMed

Mace, James; Wheelton, Andy; Khan, Wasim S; Anand, Sanj

2016-01-01

Bioreactors are pivotal to the emerging field of tissue engineering. The formation of neotissue from pluripotent cell lineages potentially offers a source of tissue for clinical use without the significant donor site morbidity associated with many contemporary surgical reconstructive procedures. Modern bioreactor design is becoming increasingly complex to provide a both an expandable source of readily available pluripotent cells and to facilitate their controlled differentiation into a clinically applicable ligament or tendon like neotissue. This review presents the need for such a method, challenges in the processes to engineer neotissue and the current designs and results of modern bioreactors in the pursuit of engineered tendon and ligament.

Modern Optimization Methods in Minimum Weight Design of Elastic Annular Rotating Disk with Variable Thickness

NASA Astrophysics Data System (ADS)

Jafari, S.; Hojjati, M. H.

2011-12-01

Rotating disks work mostly at high angular velocity and this results a large centrifugal force and consequently induce large stresses and deformations. Minimizing weight of such disks yields to benefits such as low dead weights and lower costs. This paper aims at finding an optimal disk thickness profile for minimum weight design using the simulated annealing (SA) and particle swarm optimization (PSO) as two modern optimization techniques. In using semi-analytical the radial domain of the disk is divided into some virtual sub-domains as rings where the weight of each rings must be minimized. Inequality constrain equation used in optimization is to make sure that maximum von Mises stress is always less than yielding strength of the material of the disk and rotating disk does not fail. The results show that the minimum weight obtained for all two methods is almost identical. The PSO method gives a profile with slightly less weight (6.9% less than SA) while the implementation of both PSO and SA methods are easy and provide more flexibility compared with classical methods.

Interpersonal communication as an agent of normative influence: a mixed method study among the urban poor in India.

PubMed

Rimal, Rajiv N; Sripad, Pooja; Speizer, Ilene S; Calhoun, Lisa M

2015-08-12

Although social norms are thought to play an important role in couples' reproductive decisions, only limited theoretical or empirical guidance exists on how the underlying process works. Using the theory of normative social behavior (TNSB), through a mixed-method design, we investigated the role played by injunctive norms and interpersonal discussion in the relationship between descriptive norms and use of modern contraceptive methods among the urban poor in India. Data from a household survey (N = 11,811) were used to test the underlying theoretical propositions, and focus group interviews among men and women were then conducted to obtain more in-depth knowledge about decision-making processes related to modern contraceptive use. Spousal influence and interpersonal communication emerged as key factors in decision-making, waning in the later years of marriage, and they also moderated the influence of descriptive norms on behaviors. Norms around contraceptive use, which varied by parity, are rapidly changing with the country's urbanization and increased access to health information. Open interpersonal discussion, community norms, and perspectives are integral in enabling women and couples to use modern family planning to meet their current fertility desires and warrant sensitivity in the design of family planning policy and programs.

Design and Validation of the Quantum Mechanics Conceptual Survey

ERIC Educational Resources Information Center

McKagan, S. B.; Perkins, K. K.; Wieman, C. E.

2010-01-01

The Quantum Mechanics Conceptual Survey (QMCS) is a 12-question survey of students' conceptual understanding of quantum mechanics. It is intended to be used to measure the relative effectiveness of different instructional methods in modern physics courses. In this paper, we describe the design and validation of the survey, a process that included…

Summertime Temperatures in Buildings Without Air-Conditioning.

ERIC Educational Resources Information Center

Loudon, A. G.

Many modern buildings become uncomfortably warm during sunny spells in the summer, and until recently there was no simple, reliable method of assessing at the design stage whether a building would become overheated. This paper describes a method of calculating summertime temperatures which was developed at the Building Research Station, and gives…

Natural products as inspiration for the development of new synthetic methods.

PubMed

Ma, Zhiqiang; Chen, Chuo

2018-01-01

Natural products have played an important role in shaping modern synthetic organic chemistry. In particular, their complex molecular skeletons have stimulated the development of many new synthetic methods. We highlight in this article some recent examples of synthetic design inspired by the biosynthesis of natural products.

Quake Final Video

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Critical infrastructures of the world are at constant risks for earthquakes. Most of these critical structures are designed using archaic, seismic, simulation methods that were built from early digital computers from the 1970s. Idaho National Laboratory’s Seismic Research Group are working to modernize the simulation methods through computational research and large-scale laboratory experiments.

Practical optimal flight control system design for helicopter aircraft. Volume 1: Technical Report

NASA Technical Reports Server (NTRS)

Hofmann, L. G.; Riedel, S. A.; Mcruer, D.

1980-01-01

A method by which modern and classical theory techniques may be integrated in a synergistic fashion and used in the design of practical flight control systems is presented. A general procedure is developed, and several illustrative examples are included. Emphasis is placed not only on the synthesis of the design, but on the assessment of the results as well.

Moving towards the goals of FP2020 - classifying contraceptives.

PubMed

Festin, Mario Philip R; Kiarie, James; Solo, Julie; Spieler, Jeffrey; Malarcher, Shawn; Van Look, Paul F A; Temmerman, Marleen

2016-10-01

With the renewed focus on family planning, a clear and transparent understanding is needed for the consistent classification of contraceptives, especially in the commonly used modern/traditional system. The World Health Organization Department of Reproductive Health and Research and the United States Agency for International Development (USAID) therefore convened a technical consultation in January 2015 to address issues related to classifying contraceptives. The consultation defined modern contraceptive methods as having a sound basis in reproductive biology, a precise protocol for correct use and evidence of efficacy under various conditions based on appropriately designed studies. Methods in country programs like Fertility Awareness Based Methods [such as Standard Days Method (SDM) and TwoDay Method], Lactational Amenorrhea Method (LAM) and emergency contraception should be reported as modern. Herbs, charms and vaginal douching are not counted as contraceptive methods as they have no scientific basis in preventing pregnancy nor are in country programs. More research is needed on defining and measuring use of emergency contraceptive methods, to reflect their contribution to reducing unmet need. The ideal contraceptive classification system should be simple, easy to use, clear and consistent, with greater parsimony. Measurement challenges remain but should not be the driving force to determine what methods are counted or reported as modern or not. Family planning programs should consider multiple attributes of contraceptive methods (e.g., level of effectiveness, need for program support, duration of labeled use, hormonal or nonhormonal) to ensure they provide a variety of methods to meet the needs of women and men. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Is traditional contraceptive use in Moldova associated with poverty and isolation?

PubMed

Lyons-Amos, Mark J; Durrant, Gabriele B; Padmadas, Sabu S

2011-05-01

This study investigates the correlates of traditional contraceptive use in Moldova, a poor country in Europe with one of the highest proportions of traditional contraceptive method users. The high reliance on traditional methods, particularly in the context of sub-replacement level fertility rate, has not been systematically evaluated in demographic research. Using cross-sectional data on a sub-sample of 6039 sexually experienced women from the 2005 Moldovan Demographic and Health Survey, this study hypothesizes that (a) economic and spatial disadvantages increase the likelihood of traditional method use, and (b) high exposure to family planning/reproductive health (FP/RH) programmes increases the propensity to modern method use. Multilevel multinomial models are used to examine the correlates of traditional method use controlling for exposure to sexual activity, socioeconomic and demographic characteristics and data structure. The results show that economic disadvantage increases the probability of traditional method use, but the overall effect is small. Although higher family planning media exposure decreases the reliance on traditional methods among younger women, it has only a marginal effect in increasing modern method use among older women. Family planning programmes designed to encourage women to switch from traditional to modern methods have some success--although the effect is considerably reduced in regions outside of the capital Chisinau. The study concludes that FP/RH efforts directed towards the poorest may have limited impact, but interventions targeted at older women could reduce the burden of unwanted pregnancies and abortions. Addressing differentials in accessing modern methods could improve uptake in rural areas.

Uncertainty in eddy covariance flux estimates resulting from spectral attenuation [Chapter 4

Treesearch

W. J. Massman; R. Clement

2004-01-01

Surface exchange fluxes measured by eddy covariance tend to be underestimated as a result of limitations in sensor design, signal processing methods, and finite flux-averaging periods. But, careful system design, modern instrumentation, and appropriate data processing algorithms can minimize these losses, which, if not too large, can be estimated and corrected using...

3D graphics hardware accelerator programming methods for real-time visualization systems

NASA Astrophysics Data System (ADS)

Souetov, Andrew E.

2001-02-01

The paper deals with new approaches in software design for creating real-time applications that use modern graphics acceleration hardware. The growing complexity of such type of software compels programmers to use different types of CASE systems in design and development process. The subject under discussion is integration of such systems in a development process, their effective use, and the combination of these new methods with the necessity to produce optimal codes. A method of simulation integration and modeling tools in real-time software development cycle is described.

3D graphics hardware accelerator programming methods for real-time visualization systems

NASA Astrophysics Data System (ADS)

Souetov, Andrew E.

2000-02-01

The paper deals with new approaches in software design for creating real-time applications that use modern graphics acceleration hardware. The growing complexity of such type of software compels programmers to use different types of CASE systems in design and development process. The subject under discussion is integration of such systems in a development process, their effective use, and the combination of these new methods with the necessity to produce optimal codes. A method of simulation integration and modeling tools in real-time software development cycle is described.

Concepts for the development of light-weight composite structures for rotor burst containment

NASA Technical Reports Server (NTRS)

Holms, A. G.

1977-01-01

Based on published results on rotor burst containment with single materials, and on body armor using composite materials, a set of hypotheses is established as to what variables might control the design of a weight-efficient protective device. Based on modern concepts for the design and analysis of small optimum seeking experiments, a particular experiment for evaluating the hypotheses and materials was designed. The design and methods for the analysis of results are described.

An introduction to human systems integration (HSI) in the U.S. railroad industry.

DOT National Transportation Integrated Search

2007-04-01

Human systems integration (HSI) is a systematic, organization-wide approach to : implementing new technologies and modernizing existing systems. It is a combination of : managerial philosophy, methods, techniques, and tools designed to emphasize, dur...

Automatic focusing system of BSST in Antarctic

NASA Astrophysics Data System (ADS)

Tang, Peng-Yi; Liu, Jia-Jing; Zhang, Guang-yu; Wang, Jian

2015-10-01

Automatic focusing (AF) technology plays an important role in modern astronomical telescopes. Based on the focusing requirement of BSST (Bright Star Survey Telescope) in Antarctic, an AF system is set up. In this design, functions in OpenCV is used to find stars, the algorithm of area, HFD or FWHM are used to degree the focus metric by choosing. Curve fitting method is used to find focus position as the method of camera moving. All these design are suitable for unattended small telescope.

Exposure to family planning messages and modern contraceptive use among men in urban Kenya, Nigeria, and Senegal: a cross-sectional study.

PubMed

Okigbo, Chinelo C; Speizer, Ilene S; Corroon, Meghan; Gueye, Abdou

2015-07-22

Family planning (FP) researchers and policy makers have often overlooked the importance of involving men in couples' fertility choices and contraception, despite the fact that male involvement is a vital factor in sexual and reproductive health programming. This study aimed to assess whether men's exposure to FP demand-generation activities is associated with their reported use of modern contraceptive methods. We used evaluation data from the Measurement, Learning & Evaluation project for the Urban Reproductive Health Initiative (URHI) in select cities of three African countries (Kenya, Nigeria, and Senegal) collected in 2012/2013. A two-stage cluster sampling design was used to select a representative sample of men in the study sites. The sample for this study includes men aged 15-59 years who had no missing data on any of the key variables: 696 men in Kenya, 2311 in Nigeria, and 1613 in Senegal. We conducted descriptive analyses and multivariate logistic regression analyses to assess the associations of interest. All analyses were weighted to account for the study design and non-response rates using Stata version 13. The proportion of men who reported use of modern contraceptive methods was 58 % in Kenya, 43 % in Nigeria, and 27 % in Senegal. About 80 % were exposed to at least one URHI demand-generation activity in each country. Certain URHI demand-generation activities were significantly associated with men's reported use of modern contraception. In Kenya, those who participated in URHI-led community events had four times higher odds of reporting use of modern methods (aOR: 3.70; p < 0.05) while in Senegal, exposure to URHI-television programs (aOR: 1.40; p < 0.05) and having heard a religious leader speak favorably about FP (aOR: 1.72; p < 0.05) were associated with modern contraceptive method use. No such associations were observed in Nigeria. Study findings are important for informing future FP program activities that seek to engage men. Program activities should be tailored by geographic context as results from this study indicate city and country-level variations. These types of gender-comprehensive and context-specific programs are likely to be the most successful at reducing unmet need for FP.

Adaptive designs in clinical trials.

PubMed

Bowalekar, Suresh

2011-01-01

In addition to the expensive and lengthy process of developing a new medicine, the attrition rate in clinical research was on the rise, resulting in stagnation in the development of new compounds. As a consequence to this, the US Food and Drug Administration released a critical path initiative document in 2004, highlighting the need for developing innovative trial designs. One of the innovations suggested the use of adaptive designs for clinical trials. Thus, post critical path initiative, there is a growing interest in using adaptive designs for the development of pharmaceutical products. Adaptive designs are expected to have great potential to reduce the number of patients and duration of trial and to have relatively less exposure to new drug. Adaptive designs are not new in the sense that the task of interim analysis (IA)/review of the accumulated data used in adaptive designs existed in the past too. However, such reviews/analyses of accumulated data were not necessarily planned at the stage of planning clinical trial and the methods used were not necessarily compliant with clinical trial process. The Bayesian approach commonly used in adaptive designs was developed by Thomas Bayes in the 18th century, about hundred years prior to the development of modern statistical methods by the father of modern statistics, Sir Ronald A. Fisher, but the complexity involved in Bayesian approach prevented its use in real life practice. The advances in the field of computer and information technology over the last three to four decades has changed the scenario and the Bayesian techniques are being used in adaptive designs in addition to other sequential methods used in IA. This paper attempts to describe the various adaptive designs in clinical trial and views of stakeholders about feasibility of using them, without going into mathematical complexities.

Numerical methods for the design of gradient-index optical coatings.

PubMed

Anzengruber, Stephan W; Klann, Esther; Ramlau, Ronny; Tonova, Diana

2012-12-01

We formulate the problem of designing gradient-index optical coatings as the task of solving a system of operator equations. We use iterative numerical procedures known from the theory of inverse problems to solve it with respect to the coating refractive index profile and thickness. The mathematical derivations necessary for the application of the procedures are presented, and different numerical methods (Landweber, Newton, and Gauss-Newton methods, Tikhonov minimization with surrogate functionals) are implemented. Procedures for the transformation of the gradient coating designs into quasi-gradient ones (i.e., multilayer stacks of homogeneous layers with different refractive indices) are also developed. The design algorithms work with physically available coating materials that could be produced with the modern coating technologies.

Computer methods in designing tourist equipment for people with disabilities

NASA Astrophysics Data System (ADS)

Zuzda, Jolanta GraŻyna; Borkowski, Piotr; Popławska, Justyna; Latosiewicz, Robert; Moska, Eleonora

2017-11-01

Modern technologies enable disabled people to enjoy physical activity every day. Many new structures are matched individually and created for people who fancy active tourism, giving them wider opportunities for active pastime. The process of creating this type of devices in every stage, from initial design through assessment to validation, is assisted by various types of computer support software.

The challenge of doing science in wilderness: historical, legal, and policy context

Treesearch

Peter Landres; Judy Alderson; David J. Parsons

2003-01-01

Lands designated by Congress under the Wilderness Act of 1964 (Public Law 88-577) offer unique opportunities for social and biophysical research in areas that are relatively unmodified by modern human actions. Wilderness designation also imposes a unique set of constraints on the methods that may be used or permitted to conduct this research. For example, legislated...

The Dilemma of Scripted Instruction: Comparing Teacher Autonomy, Fidelity, and Resistance in the Froebelian Kindergarten, Montessori, Direct Instruction, and Success for All

ERIC Educational Resources Information Center

Beatty, Barbara

2011-01-01

Background/Context: More than a century before modern controversies over scripted instruction, the Froebelian kindergarten--the original kindergarten method designed by Friedrich Froebel--and Maria Montessori's pedagogy were criticized for rigidly prescribing how teachers taught and children learned. Today, scripted methods such as Direct…

A Stimulating Approach To Teaching, Learning and Assessing Finite Element Methods: A Case Study.

ERIC Educational Resources Information Center

Karadelis, J. N.

1998-01-01

Examines the benefits of introducing finite element methods into the curriculum of undergraduate courses. Analyzes the structure of the computer-assisted-design module and the extent to which it fulfills its main objectives. Discusses the efficiency of modern teaching and learning techniques used to develop skills for solving engineering problems;…

Why does Japan use the probability method to set design flood?

NASA Astrophysics Data System (ADS)

Nakamura, S.; Oki, T.

2015-12-01

Design flood is hypothetical flood to make flood prevention plan. In Japan, a probability method based on precipitation data is used to define the scale of design flood: Tone River, the biggest river in Japan, is 1 in 200 years, Shinano River is 1 in 150 years, and so on. It is one of important socio-hydrological issue how to set reasonable and acceptable design flood in a changing world. The method to set design flood vary among countries. Although the probability method is also used in Netherland, but the base data is water level or discharge data and the probability is 1 in 1250 years (in fresh water section). On the other side, USA and China apply the maximum flood method which set the design flood based on the historical or probable maximum flood. This cases can leads a question: "what is the reason why the method vary among countries?" or "why does Japan use the probability method?" The purpose of this study is to clarify the historical process which the probability method was developed in Japan based on the literature. In the late 19the century, the concept of "discharge" and modern river engineering were imported by Dutch engineers, and modern flood prevention plans were developed in Japan. In these plans, the design floods were set based on the historical maximum method. Although the historical maximum method had been used until World War 2, however, the method was changed to the probability method after the war because of limitations of historical maximum method under the specific socio-economic situations: (1) the budget limitation due to the war and the GHQ occupation, (2) the historical floods: Makurazaki typhoon in 1945, Kathleen typhoon in 1947, Ione typhoon in 1948, and so on, attacked Japan and broke the record of historical maximum discharge in main rivers and the flood disasters made the flood prevention projects difficult to complete. Then, Japanese hydrologists imported the hydrological probability statistics from the West to take account of socio-economic situation in design flood, and they applied to Japanese rivers in 1958. The probability method was applied Japan to adapt the specific socio-economic and natural situation during the confusion after the war.

Analysis of Slabs-on-Grade for a Variety of Loading and Support Conditions.

DTIC Science & Technology

1984-12-01

applications, namely "- the problem of a slab-on-grade, as encountered in the analysis and design of rigid pavements. - ". This is one of the few...proper design and construction methods are adhered to. There are several additional reasons, entirely due to recent developments, that warrant the...conservative designs led to almost imperceptible pavement deformations, thus warranting the term "rigid pavements". Modern-day analytical techniques

SNCF experience in anthropometrics

NASA Astrophysics Data System (ADS)

Boutonnet, J. C.

1986-07-01

The lecturer describes the methods and the means to design in relation with anthropometrics datas the driving cab of modern SNCF vehicles such as the SYBIC universal locomotive and the TGV-Atlantique power car vehicle is to operate in the end of the decade.

Invited commentary: do-it-yourself modern epidemiology--at last!

PubMed

Morabia, Alfredo

2014-10-01

In this issue of the Journal, Keyes and Galea (Am J Epidemiol. 2014;180(7):661-668) propose "7 foundational steps" for introducing epidemiologic methods and concepts to beginners. Keyes and Galea's credo is that the methododological and conceptual components that comprise epidemiology, today scattered in textbook chapters, come together as an integrated and coherent methodological corpus in the process of designing studies. Thus, they expound, the process of designing studies should be the core of teaching epidemiology. Two aspects of their 7-steps-to-epidemiology, do-it-yourself user manual stand out as novel: 1) the approach, because of its emphasis on modern epidemiology's causal framework of a dynamic population in a steady state evolving across time, and 2) the ambition to teach modern epidemiology in introductory courses, instead of the popular mix of classical and modern epidemiology that is often used today to keep introductory courses simple. Both aspects are of potentially great significance for our discipline. © The Author 2014. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Developing and applying modern methods of leakage monitoring and state estimation of fuel at the Novovoronezh nuclear power plant

NASA Astrophysics Data System (ADS)

Povarov, V. P.; Tereshchenko, A. B.; Kravchenko, Yu. N.; Pozychanyuk, I. V.; Gorobtsov, L. I.; Golubev, E. I.; Bykov, V. I.; Likhanskii, V. V.; Evdokimov, I. A.; Zborovskii, V. G.; Sorokin, A. A.; Kanyukova, V. D.; Aliev, T. N.

2014-02-01

The results of developing and implementing the modernized fuel leakage monitoring methods at the shut-down and running reactor of the Novovoronezh nuclear power plant (NPP) are presented. An automated computerized expert system integrated with an in-core monitoring system (ICMS) and installed at the Novovoronezh NPP unit no. 5 is described. If leaky fuel elements appear in the core, the system allows one to perform on-line assessment of the parameters of leaky fuel assemblies (FAs). The computer expert system units designed for optimizing the operating regimes and enhancing the fuel usage efficiency at the Novovoronezh NPP unit no. 5 are now being developed.

Aerodynamic Shape Optimization Using Hybridized Differential Evolution

NASA Technical Reports Server (NTRS)

Madavan, Nateri K.

2003-01-01

An aerodynamic shape optimization method that uses an evolutionary algorithm known at Differential Evolution (DE) in conjunction with various hybridization strategies is described. DE is a simple and robust evolutionary strategy that has been proven effective in determining the global optimum for several difficult optimization problems. Various hybridization strategies for DE are explored, including the use of neural networks as well as traditional local search methods. A Navier-Stokes solver is used to evaluate the various intermediate designs and provide inputs to the hybrid DE optimizer. The method is implemented on distributed parallel computers so that new designs can be obtained within reasonable turnaround times. Results are presented for the inverse design of a turbine airfoil from a modern jet engine. (The final paper will include at least one other aerodynamic design application). The capability of the method to search large design spaces and obtain the optimal airfoils in an automatic fashion is demonstrated.

Comparing an FPGA to a Cell for an Image Processing Application

NASA Astrophysics Data System (ADS)

Rakvic, Ryan N.; Ngo, Hau; Broussard, Randy P.; Ives, Robert W.

2010-12-01

Modern advancements in configurable hardware, most notably Field-Programmable Gate Arrays (FPGAs), have provided an exciting opportunity to discover the parallel nature of modern image processing algorithms. On the other hand, PlayStation3 (PS3) game consoles contain a multicore heterogeneous processor known as the Cell, which is designed to perform complex image processing algorithms at a high performance. In this research project, our aim is to study the differences in performance of a modern image processing algorithm on these two hardware platforms. In particular, Iris Recognition Systems have recently become an attractive identification method because of their extremely high accuracy. Iris matching, a repeatedly executed portion of a modern iris recognition algorithm, is parallelized on an FPGA system and a Cell processor. We demonstrate a 2.5 times speedup of the parallelized algorithm on the FPGA system when compared to a Cell processor-based version.

Use of modern contraceptives among married women in Vietnam: a multilevel analysis using the Multiple Indicator Cluster Survey (2011) and the Vietnam Population and Housing Census (2009)

PubMed Central

Vu, Lan Thi Hoang; Oh, Juhwan; Bui, Quyen Thi-Tu; Le, Anh Thi-Kim

2016-01-01

Background The prevalence of modern contraceptive use is an important indicator that reflects accessibility to reproductive health services. Satisfying unmet needs for family planning alone could reduce the number of maternal deaths by almost a third. This study uses multiple data sources to examine multilevel factors associated with the use of modern contraceptives among married women in Vietnam aged 15–49 years. Design Data from different national surveys (Vietnam Population and Housing Census, Vietnam Living Standard Survey, and Multiple Indicator Cluster Survey) were linked to create a dataset including individual and contextual (provincial) variables (N=8,341). Multilevel modeling was undertaken to examine the impact of both individual and provincial characteristics on modern contraceptive use. Odds ratios (ORs) and 95% confidence intervals (CIs) are reported. Results Individual factors significantly associated with the use of modern contraceptives were age 30–34 years (reference 15–19 years) (OR=1.63); high socioeconomic status (SES) (OR=0.8); having two living children (OR=2.4); and having a son (OR=1.4). The provincial poverty rate mediated the association between the individual's SES and the likelihood of using modern contraceptives. Conclusions The proportion of women in Vietnam using modern contraceptive methods has remained relatively high in recent years with significant variation across Vietnam's 63 provinces. Women of lower SES are more likely to use modern contraceptive methods, especially in the poorer provinces. Achieving access to universal reproductive health is one of the Millennium Development Goals. Vietnam must continue to make progress in this area. PMID:26950565

Comparison of Resource Requirements for a Wind Tunnel Test Designed with Conventional vs. Modern Design of Experiments Methods

NASA Technical Reports Server (NTRS)

DeLoach, Richard; Micol, John R.

2011-01-01

The factors that determine data volume requirements in a typical wind tunnel test are identified. It is suggested that productivity in wind tunnel testing can be enhanced by managing the inference error risk associated with evaluating residuals in a response surface modeling experiment. The relationship between minimum data volume requirements and the factors upon which they depend is described and certain simplifications to this relationship are realized when specific model adequacy criteria are adopted. The question of response model residual evaluation is treated and certain practical aspects of response surface modeling are considered, including inference subspace truncation. A wind tunnel test plan developed by using the Modern Design of Experiments illustrates the advantages of an early estimate of data volume requirements. Comparisons are made with a representative One Factor At a Time (OFAT) wind tunnel test matrix developed to evaluate a surface to air missile.

Space Suit Performance: Methods for Changing the Quality of Quantitative Data

NASA Technical Reports Server (NTRS)

Cowley, Matthew; Benson, Elizabeth; Rajulu, Sudhakar

2014-01-01

NASA is currently designing a new space suit capable of working in deep space and on Mars. Designing a suit is very difficult and often requires trade-offs between performance, cost, mass, and system complexity. To verify that new suits will enable astronauts to perform to their maximum capacity, prototype suits must be built and tested with human subjects. However, engineers and flight surgeons often have difficulty understanding and applying traditional representations of human data without training. To overcome these challenges, NASA is developing modern simulation and analysis techniques that focus on 3D visualization. Early understanding of actual performance early on in the design cycle is extremely advantageous to increase performance capabilities, reduce the risk of injury, and reduce costs. The primary objective of this project was to test modern simulation and analysis techniques for evaluating the performance of a human operating in extra-vehicular space suits.

New methods and materials for molding and casting ice formations

NASA Technical Reports Server (NTRS)

Reehorst, Andrew L.; Richter, G. Paul

1987-01-01

This study was designed to find improved materials and techniques for molding and casting natural or simulated ice shapes that could replace the wax and plaster method. By utilizing modern molding and casting materials and techniques, a new methodology was developed that provides excellent reproduction, low-temperature capability, and reasonable turnaround time. The resulting casts are accurate and tough.

High-performance equation solvers and their impact on finite element analysis

NASA Technical Reports Server (NTRS)

Poole, Eugene L.; Knight, Norman F., Jr.; Davis, D. Dale, Jr.

1990-01-01

The role of equation solvers in modern structural analysis software is described. Direct and iterative equation solvers which exploit vectorization on modern high-performance computer systems are described and compared. The direct solvers are two Cholesky factorization methods. The first method utilizes a novel variable-band data storage format to achieve very high computation rates and the second method uses a sparse data storage format designed to reduce the number of operations. The iterative solvers are preconditioned conjugate gradient methods. Two different preconditioners are included; the first uses a diagonal matrix storage scheme to achieve high computation rates and the second requires a sparse data storage scheme and converges to the solution in fewer iterations that the first. The impact of using all of the equation solvers in a common structural analysis software system is demonstrated by solving several representative structural analysis problems.

High-performance equation solvers and their impact on finite element analysis

NASA Technical Reports Server (NTRS)

Poole, Eugene L.; Knight, Norman F., Jr.; Davis, D. D., Jr.

1992-01-01

The role of equation solvers in modern structural analysis software is described. Direct and iterative equation solvers which exploit vectorization on modern high-performance computer systems are described and compared. The direct solvers are two Cholesky factorization methods. The first method utilizes a novel variable-band data storage format to achieve very high computation rates and the second method uses a sparse data storage format designed to reduce the number od operations. The iterative solvers are preconditioned conjugate gradient methods. Two different preconditioners are included; the first uses a diagonal matrix storage scheme to achieve high computation rates and the second requires a sparse data storage scheme and converges to the solution in fewer iterations that the first. The impact of using all of the equation solvers in a common structural analysis software system is demonstrated by solving several representative structural analysis problems.

Writer identification on historical Glagolitic documents

NASA Astrophysics Data System (ADS)

Fiel, Stefan; Hollaus, Fabian; Gau, Melanie; Sablatnig, Robert

2013-12-01

This work aims at automatically identifying scribes of historical Slavonic manuscripts. The quality of the ancient documents is partially degraded by faded-out ink or varying background. The writer identification method used is based on image features, which are described with Scale Invariant Feature Transform (SIFT) features. A visual vocabulary is used for the description of handwriting characteristics, whereby the features are clustered using a Gaussian Mixture Model and employing the Fisher kernel. The writer identification approach is originally designed for grayscale images of modern handwritings. But contrary to modern documents, the historical manuscripts are partially corrupted by background clutter and water stains. As a result, SIFT features are also found on the background. Since the method shows also good results on binarized images of modern handwritings, the approach was additionally applied on binarized images of the ancient writings. Experiments show that this preprocessing step leads to a significant performance increase: The identification rate on binarized images is 98.9%, compared to an identification rate of 87.6% gained on grayscale images.

Design of Rail Instrumentation for Wind Tunnel Sonic Boom Measurements and Computational-Experimental Comparisons

NASA Technical Reports Server (NTRS)

Cliff, Susan E.; Elmiligui, A.; Aftosmis, M.; Morgenstern, J.; Durston, D.; Thomas, S.

2012-01-01

An innovative pressure rail concept for wind tunnel sonic boom testing of modern aircraft configurations with very low overpressures was designed with an adjoint-based solution-adapted Cartesian grid method. The computational method requires accurate free-air calculations of a test article as well as solutions modeling the influence of rail and tunnel walls. Specialized grids for accurate Euler and Navier-Stokes sonic boom computations were used on several test articles including complete aircraft models with flow-through nacelles. The computed pressure signatures are compared with recent results from the NASA 9- x 7-foot Supersonic Wind Tunnel using the advanced rail design.

Optimization of the current potential for stellarator coils

NASA Astrophysics Data System (ADS)

Boozer, Allen H.

2000-02-01

Stellarator plasma confinement devices have no continuous symmetries, which makes the design of appropriate coils far more subtle than for axisymmetric devices such as tokamaks. The modern method for designing coils for stellarators was developed by Peter Merkel [P. Merkel, Nucl. Fusion 27, 867 (1987)]. Although his method has yielded a number of successful stellarator designs, Merkel's method has a systematic tendency to give coils with a larger current than that required to produce a stellarator plasma with certain properties. In addition, Merkel's method does not naturally lead to a coil set with the flexibility to produce a number of interesting plasma configurations. The issues of coil efficiency and flexibility are addressed in this paper by a new method of optimizing the current potential, the first step in Merkel's method. The new method also allows the coil design to be based on a freer choice for the plasma-coil separation and to be constrained so space is preserved for plasma access.

Optimization of the current potential for stellarator coils

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boozer, Allen H.; Max-Planck-Institut fuer Plasmaphysik, EURATOM-Association, D-85748 Garching,

2000-02-01

Stellarator plasma confinement devices have no continuous symmetries, which makes the design of appropriate coils far more subtle than for axisymmetric devices such as tokamaks. The modern method for designing coils for stellarators was developed by Peter Merkel [P. Merkel, Nucl. Fusion 27, 867 (1987)]. Although his method has yielded a number of successful stellarator designs, Merkel's method has a systematic tendency to give coils with a larger current than that required to produce a stellarator plasma with certain properties. In addition, Merkel's method does not naturally lead to a coil set with the flexibility to produce a number ofmore » interesting plasma configurations. The issues of coil efficiency and flexibility are addressed in this paper by a new method of optimizing the current potential, the first step in Merkel's method. The new method also allows the coil design to be based on a freer choice for the plasma-coil separation and to be constrained so space is preserved for plasma access. (c) 2000 American Institute of Physics.« less

Modernization of the Transonic Axial Compressor Test Rig

DTIC Science & Technology

2017-12-01

13. ABSTRACT (maximum 200 words) This work presents the design and simulation process of modernizing the Naval Postgraduate School’s transonic...fabricate the materials. Stiffness tests and modal analysis were conducted via Finite Element Analysis (FEA) software. This analysis was used to design ...work presents the design and simulation process of modernizing the Naval Postgraduate School’s transonic compressor test rig (TCR). The TCR, which

Heat transfer technology for internal passages of air-cooled blades for heavy-duty gas turbines.

PubMed

Weigand, B; Semmler, K; von Wolfersdorf, J

2001-05-01

The present review paper, although far from being complete, aims to give an overview about the present state of the art in the field of heat transfer technology for internal cooling of gas turbine blades. After showing some typical modern cooled blades, the different methods to enhance heat transfer in the internal passages of air-cooled blades are discussed. The complicated flows occurring in bends are described in detail, because of their increasing importance for modern cooling designs. A short review about testing of cooling design elements is given, showing the interaction of the different cooling features as well. The special focus of the present review has been put on the cooling of blades for heavy-duty gas turbines, which show several differences compared to aero-engine blades.

Design of Unstructured Adaptive (UA) NAS Parallel Benchmark Featuring Irregular, Dynamic Memory Accesses

NASA Technical Reports Server (NTRS)

Feng, Hui-Yu; VanderWijngaart, Rob; Biswas, Rupak; Biegel, Bryan (Technical Monitor)

2001-01-01

We describe the design of a new method for the measurement of the performance of modern computer systems when solving scientific problems featuring irregular, dynamic memory accesses. The method involves the solution of a stylized heat transfer problem on an unstructured, adaptive grid. A Spectral Element Method (SEM) with an adaptive, nonconforming mesh is selected to discretize the transport equation. The relatively high order of the SEM lowers the fraction of wall clock time spent on inter-processor communication, which eases the load balancing task and allows us to concentrate on the memory accesses. The benchmark is designed to be three-dimensional. Parallelization and load balance issues of a reference implementation will be described in detail in future reports.

Design and study of water supply system for supercritical unit boiler in thermal power station

NASA Astrophysics Data System (ADS)

Du, Zenghui

2018-04-01

In order to design and optimize the boiler feed water system of supercritical unit, the establishment of a highly accurate controlled object model and its dynamic characteristics are prerequisites for developing a perfect thermal control system. In this paper, the method of mechanism modeling often leads to large systematic errors. Aiming at the information contained in the historical operation data of the boiler typical thermal system, the modern intelligent identification method to establish a high-precision quantitative model is used. This method avoids the difficulties caused by the disturbance experiment modeling for the actual system in the field, and provides a strong reference for the design and optimization of the thermal automation control system in the thermal power plant.

Software development for airborne radar

NASA Astrophysics Data System (ADS)

Sundstrom, Ingvar G.

Some aspects for development of software in a modern multimode airborne nose radar are described. First, an overview of where software is used in the radar units is presented. The development phases-system design, functional design, detailed design, function verification, and system verification-are then used as the starting point for the discussion. Methods, tools, and the most important documents are described. The importance of video flight recording in the early stages and use of a digital signal generators for performance verification is emphasized. Some future trends are discussed.

Laser manufacturing: strategies for dealing with the challenges

NASA Astrophysics Data System (ADS)

Barr, John R. M.

2012-09-01

Laser manufacturing in Edinburgh was initiated in 1963 by Ferranti (one of the previous names for SELEX Galileo). Since 2003 a modernized range of military lasers has been established. Innovation, both technical and in other aspects of the business, has enabled the design and manufacture of world leading laser designators and countermeasure lasers. Specific examples will be given including: the application of Geometric Algebra to resonator design; novel alignment free optical parametric oscillators; techniques for designing thermally insensitive laser diode pump heads; and methods for contamination control in lasers.

Civil and mechanical engineering applications of sensitivity analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Komkov, V.

1985-07-01

In this largely tutorial presentation, the historical development of optimization theories has been outlined as they applied to mechanical and civil engineering designs and the development of modern sensitivity techniques during the last 20 years has been traced. Some of the difficulties and the progress made in overcoming them have been outlined. Some of the recently developed theoretical methods have been stressed to indicate their importance to computer-aided design technology.

Survival analysis of time to uptake of modern contraceptives among sexually active women of reproductive age in Nigeria

PubMed Central

Adebowale, Ayo Stephen; Morhason-Bello, ImranOludare

2015-01-01

Objective To assess the timing of modern contraceptive uptake among married and never-married women in Nigeria. Design A retrospective cross-sectional study. Data and method We used nationally representative 2013 Demographic and Health Survey data in Nigeria. Modern contraceptive uptake time was measured as the period between first sexual intercourse and first use of a modern contraceptive. Non-users of modern contraceptives were censored on the date of the survey. Kaplan–Meier survival curves were used to determine the rate of uptake. A Cox proportional-hazards model was used to determine variables influencing the uptake at 5% significance level. Participants A total of 33 223 sexually active women of reproductive age. Outcome measure Time of uptake of a modern contraceptive after first sexual intercourse. Results The median modern contraceptive uptake time was 4 years in never-married and 14 years among ever-married women. Significant differences in modern contraceptive uptake existed in respondents’ age, location, education and wealth status. Never-married women were about three times more likely to use a modern contraceptive than ever-married women (aHR=3.24 (95% CI 2.82 to 3.65)). Women with higher education were six times more likely to use a modern contraceptive than those without education (aHR=6.18 (95% CI 5.15 to 7.42)). Conclusions The rate of modern contraceptive uptake is low, and timing of contraceptive uptake during or after first sexual intercourse differed according to marital status. Age and number of children ever born influenced modern contraceptive uptake among the never-married women, but religion and place of residence were associated with the probability of modern contraceptive uptake among ever-married women. PMID:26671948

Scaling Support Vector Machines On Modern HPC Platforms

DOE Office of Scientific and Technical Information (OSTI.GOV)

You, Yang; Fu, Haohuan; Song, Shuaiwen

2015-02-01

We designed and implemented MIC-SVM, a highly efficient parallel SVM for x86 based multicore and many-core architectures, such as the Intel Ivy Bridge CPUs and Intel Xeon Phi co-processor (MIC). We propose various novel analysis methods and optimization techniques to fully utilize the multilevel parallelism provided by these architectures and serve as general optimization methods for other machine learning tools.

Incompressible boundary-layer stability analysis of LFC experimental data for sub-critical Mach numbers. M.S. Thesis

NASA Technical Reports Server (NTRS)

Berry, S. A.

1986-01-01

An incompressible boundary-layer stability analysis of Laminar Flow Control (LFC) experimental data was completed and the results are presented. This analysis was undertaken for three reasons: to study laminar boundary-layer stability on a modern swept LFC airfoil; to calculate incompressible design limits of linear stability theory as applied to a modern airfoil at high subsonic speeds; and to verify the use of linear stability theory as a design tool. The experimental data were taken from the slotted LFC experiment recently completed in the NASA Langley 8-Foot Transonic Pressure Tunnel. Linear stability theory was applied and the results were compared with transition data to arrive at correlated n-factors. Results of the analysis showed that for the configuration and cases studied, Tollmien-Schlichting (TS) amplification was the dominating disturbance influencing transition. For these cases, incompressible linear stability theory correlated with an n-factor for TS waves of approximately 10 at transition. The n-factor method correlated rather consistently to this value despite a number of non-ideal conditions which indicates the method is useful as a design tool for advanced laminar flow airfoils.

Further Development of an Optimal Design Approach Applied to Axial Magnetic Bearings

NASA Technical Reports Server (NTRS)

Bloodgood, V. Dale, Jr.; Groom, Nelson J.; Britcher, Colin P.

2000-01-01

Classical design methods involved in magnetic bearings and magnetic suspension systems have always had their limitations. Because of this, the overall effectiveness of a design has always relied heavily on the skill and experience of the individual designer. This paper combines two approaches that have been developed to aid the accuracy and efficiency of magnetostatic design. The first approach integrates classical magnetic circuit theory with modern optimization theory to increase design efficiency. The second approach uses loss factors to increase the accuracy of classical magnetic circuit theory. As an example, an axial magnetic thrust bearing is designed for minimum power.

Telling War Stories: The Things They Carry

ERIC Educational Resources Information Center

Paquette, Paige; Warren, Mike

2010-01-01

This webtext reveals two modern-day methods for soldiers to share their war stories: 1) soldiers sharing their stories with cadets from West Point through a project linking veterans from the Global War on Terror with composition students; and 2) soldiers learning in online composition classrooms designed specifically for them.

Terminologie de Base de la Documentation. (Basic Terminology of Documentation).

ERIC Educational Resources Information Center

Commission des Communautes Europeennes (Luxembourg). Bureau de Terminologie.

This glossary is designed to aid non-specialists whose activities require that they have some familiarity with the terminology of the modern methods of documentation. Definitions have been assembled from various dictionaries, manuals, etc., with particular attention being given to the publications of UNESCO and the International Standards…

Intriguing Freshmen with Materials Science.

ERIC Educational Resources Information Center

Pond, Robert B., Sr.

Described is a course designed for engineering science and natural science freshmen and open to upperclass nonscience majors entitled "Science of Modern Materials" and which has been successfully presented for several years. This paper presents the philosophy behind the course, the teaching methods employed, and the content of the course. The…

Washington Manual: A New Tool for Local School Accounting

ERIC Educational Resources Information Center

Federal Aid Planner, 1972

1972-01-01

An advance glimpse of the revised financial accounting methods for school districts recommended in a new manual from the U. S. Office of Education. The manual is designed to help school districts modernize their financial accounting procedures and their entire range of fiscal management practices. (Author/DN)

Effectiveness of demand generation interventions on use of modern contraceptives in low- and middle-income countries.

PubMed

Belaid, L; Dumont, A; Chaillet, N; Zertal, A; De Brouwere, V; Hounton, S; Ridde, V

2016-10-01

To synthesise evidence on the implementation, costs and cost-effectiveness of demand generation interventions and their effectiveness in improving uptake of modern contraception methods. A Cochrane systematic review was conducted. Searches were performed in electronic databases (MEDLINE, EMBASE) and the grey literature. Randomised controlled trials, cluster randomised trials and quasi-experimental studies, including controlled before-after studies (CBAs) and cost and cost-effectiveness studies that aimed to assess demand interventions (including community- and facility-based interventions, financial mechanisms and mass media campaigns) in low- and middle-income countries were considered. Meta-analyses and narrative synthesis were conducted. In total, 20 papers meeting the inclusion criteria were included in this review. Of those, 13 were used for meta-analysis. Few data were available on implementation and on the influence of context on demand interventions. Involving family members during counselling, providing education activities and increasing exposure to those activities could enhance the success of demand interventions. Demand generation interventions were positively associated with increases in current use (pooled OR 1.57; 95% CI: 1.46-1.69, P < 0.01). Financial mechanism interventions (vouchers) appeared effective to increase use of modern contraceptive methods (pooled OR 2.16; 95% CI: 1.91-2.45, P < 0.01; I 2 = 0%). Demand interventions improved knowledge (pooled OR 1.02; 95% CI 0.63-1.64, P = 0.93) and attitudes towards family planning and improved discussion with partners/husbands around modern contraceptive methods. However, given the limited number of studies included in each category of demand generation interventions, the dates of publication of the studies and their low quality, caution is advised in considering the results. Very limited evidence was available on costs; studies including data on costs were old and inconsistent. Demand generation interventions contribute to increases in modern contraceptive methods use. However, more studies with robust designs are needed to identify the most effective demand generation intervention to increase uptake of modern contraceptive methods. More evidence is also needed about implementation, costs and cost-effectiveness to inform decisions on sustainability and scaling-up. © 2016 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd.

Double degree master program: Optical Design

NASA Astrophysics Data System (ADS)

Bakholdin, Alexey; Kujawinska, Malgorzata; Livshits, Irina; Styk, Adam; Voznesenskaya, Anna; Ezhova, Kseniia; Ermolayeva, Elena; Ivanova, Tatiana; Romanova, Galina; Tolstoba, Nadezhda

2015-10-01

Modern tendencies of higher education require development of master programs providing achievement of learning outcomes corresponding to quickly variable job market needs. ITMO University represented by Applied and Computer Optics Department and Optical Design and Testing Laboratory jointly with Warsaw University of Technology represented by the Institute of Micromechanics and Photonics at The Faculty of Mechatronics have developed a novel international master double-degree program "Optical Design" accumulating the expertise of both universities including experienced teaching staff, educational technologies, and experimental resources. The program presents studies targeting research and professional activities in high-tech fields connected with optical and optoelectronics devices, optical engineering, numerical methods and computer technologies. This master program deals with the design of optical systems of various types, assemblies and layouts using computer modeling means; investigation of light distribution phenomena; image modeling and formation; development of optical methods for image analysis and optical metrology including optical testing, materials characterization, NDT and industrial control and monitoring. The goal of this program is training a graduate capable to solve a wide range of research and engineering tasks in optical design and metrology leading to modern manufacturing and innovation. Variability of the program structure provides its flexibility and adoption according to current job market demands and personal learning paths for each student. In addition considerable proportion of internship and research expands practical skills. Some special features of the "Optical Design" program which implements the best practices of both Universities, the challenges and lessons learnt during its realization are presented in the paper.

Group versus individual family planning counseling in Ghana: a randomized, noninferiority trial.

PubMed

Schwandt, Hilary M; Creanga, Andreea A; Danso, Kwabena A; Adanu, Richard M K; Agbenyega, Tsiri; Hindin, Michelle J

2013-08-01

Group, rather than individual, family planning counseling has the potential to increase family planning knowledge and use through more efficient use of limited human resources. A randomized, noninferiority study design was utilized to identify whether group family planning counseling is as effective as individual family planning counseling in Ghana. Female gynecology patients were enrolled from two teaching hospitals in Ghana in June and July 2008. Patients were randomized to receive either group or individual family planning counseling. The primary outcome in this study was change in modern contraceptive method knowledge. Changes in family planning use intention before and after the intervention and intended method type were also explored. Comparisons between the two study arms suggest that randomization was successful. The difference in change in modern contraceptive methods known from baseline to follow-up between the two study arms (group-individual), adjusted for study site, was -0.21, (95% confidence interval: -0.53 to 0.12) suggesting no difference between the two arms. Group family planning counseling was as effective as individual family planning counseling in increasing modern contraceptive knowledge among female gynecology patients in Ghana. Copyright © 2013 Elsevier Inc. All rights reserved.

Monitoring the Error Rate of Modern Methods of Construction Based on Wood

NASA Astrophysics Data System (ADS)

Švajlenka, Jozef; Kozlovská, Mária

2017-06-01

A range of new and innovative construction systems, currently developed, represent modern methods of construction (MMC), which has the ambition to improve the performance parameters of buildings throughout their life cycle. Regarding the implementation modern methods of construction in Slovakia, assembled buildings based on wood seem to be the most preferred construction system. In the study, presented in the paper, were searched already built and lived-in wood based family houses. The residents' attitudes to such type of buildings in the context with declared designing and qualitative parameters of efficiency and sustainability are overlooked. The methodology of the research study is based on the socio-economic survey carried out during the years 2015 - 2017 within the Slovak Republic. Due to the large extent of data collected through questionnaire, only selected parts of the survey results are evaluated and discussed in the paper. This paper is aimed at evaluating the quality of buildings expressed in a view of users of existing wooden buildings. Research indicates some defects, which can be eliminated in the next production process. Research indicates, that some defects occur, so the production process quality should be improved in the future development.

Engineering Design Theory: Applying the Success of the Modern World to Campaign Creation

DTIC Science & Technology

2009-05-21

and school of thought) to the simple methods of design.6 This progression is analogous to Peter Senge’s levels of learning disciplines.7 Senge...iterative learning and adaptive action that develops and employs critical and creative thinking , enabling leaders to apply the necessary logic to...overcome mental rigidity and develop group insight, the Army must learn to utilize group learning and thinking , through a fluid and creative open process

Improvement of Steam Turbine Operational Performance and Reliability with using Modern Information Technologies

NASA Astrophysics Data System (ADS)

Brezgin, V. I.; Brodov, Yu M.; Kultishev, A. Yu

2017-11-01

The report presents improvement methods review in the fields of the steam turbine units design and operation based on modern information technologies application. In accordance with the life cycle methodology support, a conceptual model of the information support system during life cycle main stages (LC) of steam turbine unit is suggested. A classifying system, which ensures the creation of sustainable information links between the engineer team (manufacture’s plant) and customer organizations (power plants), is proposed. Within report, the principle of parameterization expansion beyond the geometric constructions at the design and improvement process of steam turbine unit equipment is proposed, studied and justified. The report presents the steam turbine unit equipment design methodology based on the brand new oil-cooler design system that have been developed and implemented by authors. This design system combines the construction subsystem, which is characterized by extensive usage of family tables and templates, and computation subsystem, which includes a methodology for the thermal-hydraulic zone-by-zone oil coolers design calculations. The report presents data about the developed software for operational monitoring, assessment of equipment parameters features as well as its implementation on five power plants.

The appropriateness of density-functional theory for the calculation of molecular electronics properties.

PubMed

Reimers, Jeffrey R; Cai, Zheng-Li; Bilić, Ante; Hush, Noel S

2003-12-01

As molecular electronics advances, efficient and reliable computation procedures are required for the simulation of the atomic structures of actual devices, as well as for the prediction of their electronic properties. Density-functional theory (DFT) has had widespread success throughout chemistry and solid-state physics, and it offers the possibility of fulfilling these roles. In its modern form it is an empirically parameterized approach that cannot be extended toward exact solutions in a prescribed way, ab initio. Thus, it is essential that the weaknesses of the method be identified and likely shortcomings anticipated in advance. We consider four known systematic failures of modern DFT: dispersion, charge transfer, extended pi conjugation, and bond cleavage. Their ramifications for molecular electronics applications are outlined and we suggest that great care is required when using modern DFT to partition charge flow across electrode-molecule junctions, screen applied electric fields, position molecular orbitals with respect to electrode Fermi energies, and in evaluating the distance dependence of through-molecule conductivity. The causes of these difficulties are traced to errors inherent in the types of density functionals in common use, associated with their inability to treat very long-range electron correlation effects. Heuristic enhancements of modern DFT designed to eliminate individual problems are outlined, as are three new schemes that each represent significant departures from modern DFT implementations designed to provide a priori improvements in at least one and possible all problem areas. Finally, fully semiempirical schemes based on both Hartree-Fock and Kohn-Sham theory are described that, in the short term, offer the means to avoid the inherent problems of modern DFT and, in the long term, offer competitive accuracy at dramatically reduced computational costs.

Chaotic dynamical aperture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, S.Y.; Tepikian, S.

1985-01-01

Nonlinear magnetic forces become more important for particles in the modern large accelerators. These nonlinear elements are introduced either intentionally to control beam dynamics or by uncontrollable random errors. Equations of motion in the nonlinear Hamiltonian are usually non-integrable. Because of the nonlinear part of the Hamiltonian, the tune diagram of accelerators is a jungle. Nonlinear magnet multipoles are important in keeping the accelerator operation point in the safe quarter of the hostile jungle of resonant tunes. Indeed, all the modern accelerator designs have taken advantages of nonlinear mechanics. On the other hand, the effect of the uncontrollable random multipolesmore » should be evaluated carefully. A powerful method of studying the effect of these nonlinear multipoles is using a particle tracking calculation, where a group of test particles are tracing through these magnetic multipoles in the accelerator hundreds to millions of turns in order to test the dynamical aperture of the machine. These methods are extremely useful in the design of a large accelerator such as SSC, LEP, HERA and RHIC. These calculations unfortunately take a tremendous amount of computing time. In this review the method of determining chaotic orbit and applying the method to nonlinear problems in accelerator physics is discussed. We then discuss the scaling properties and effect of random sextupoles.« less

Recent theoretical developments and experimental studies pertinent to vortex flow aerodynamics - With a view towards design

NASA Technical Reports Server (NTRS)

Lamar, J. E.; Luckring, J. M.

1978-01-01

A review is presented of recent progress in a research program directed towards the development of an improved vortex-flow technology base. It is pointed out that separation induced vortex-flows from the leading and side edges play an important role in the high angle-of-attack aerodynamic characteristics of a wide range of modern aircraft. In the analysis and design of high-speed aircraft, a detailed knowledge of this type of separation is required, particularly with regard to critical wind loads and the stability and performance at various off-design conditions. A description of analytical methods is presented. The theoretical methods employed are divided into two classes which are dependent upon the underlying aerodynamic assumptions. One conical flow method is considered along with three different nonconical flow methods. Comparisons are conducted between the described methods and available aerodynamic data. Attention is also given to a vortex flow drag study and a vortex flow wing design using suction analogy.

An intelligent, knowledge-based multiple criteria decision making advisor for systems design

NASA Astrophysics Data System (ADS)

Li, Yongchang

In systems engineering, design and operation of systems are two main problems which always attract researcher's attentions. The accomplishment of activities in these problems often requires proper decisions to be made so that the desired goal can be achieved, thus, decision making needs to be carefully fulfilled in the design and operation of systems. Design is a decision making process which permeates through out the design process, and is at the core of all design activities. In modern aircraft design, more and more attention is paid to the conceptual and preliminary design phases so as to increase the odds of choosing a design that will ultimately be successful at the completion of the design process, therefore, decisions made during these early design stages play a critical role in determining the success of a design. Since aerospace systems are complex systems with interacting disciplines and technologies, the Decision Makers (DMs) dealing with such design problems are involved in balancing the multiple, potentially conflicting attributes/criteria, transforming a large amount of customer supplied guidelines into a solidly defined set of requirement definitions. Thus, one could state with confidence that modern aerospace system design is a Multiple Criteria Decision Making (MCDM) process. A variety of existing decision making methods are available to deal with this type of decision problems. The selection of the most appropriate decision making method is of particular importance since inappropriate decision methods are likely causes of misleading engineering design decisions. With no sufficient knowledge about each of the methods, it is usually difficult for the DMs to find an appropriate analytical model capable of solving their problems. In addition, with the complexity of the decision problem and the demand for more capable methods increasing, new decision making methods are emerging with time. These various methods exacerbate the difficulty of the selection of an appropriate decision making method. Furthermore, some DMs may be exclusively using one or two specific methods which they are familiar with or trust and not realizing that they may be inappropriate to handle certain classes of the problems, thus yielding erroneous results. These issues reveal that in order to ensure a good decision a suitable decision method should be chosen before the decision making process proceeds. The first part of this dissertation proposes an MCDM process supported by an intelligent, knowledge-based advisor system referred to as Multi-Criteria Interactive Decision-Making Advisor and Synthesis process (MIDAS), which is able to facilitate the selection of the most appropriate decision making method and which provides insight to the user for fulfilling different preferences. The second part of this dissertation presents an autonomous decision making advisor which is capable of dealing with ever-evolving real time information and making autonomous decisions under uncertain conditions. The advisor encompasses a Markov Decision Process (MDP) formulation which takes uncertainty into account when determines the best action for each system state. (Abstract shortened by UMI.)

The unique role of halogen substituents in the design of modern agrochemicals.

PubMed

Jeschke, Peter

2010-01-01

The past 30 years have witnessed a period of significant expansion in the use of halogenated compounds in the field of agrochemical research and development. The introduction of halogens into active ingredients has become an important concept in the quest for a modern agrochemical with optimal efficacy, environmental safety, user friendliness and economic viability. Outstanding progress has been made, especially in synthetic methods for particular halogen-substituted key intermediates that were previously prohibitively expensive. Interestingly, there has been a rise in the number of commercial products containing 'mixed' halogens, e.g. one or more fluorine, chlorine, bromine or iodine atoms in addition to one or more further halogen atoms. Extrapolation of the current trend indicates that a definite growth is to be expected in fluorine-substituted agrochemicals throughout the twenty-first century. A number of these recently developed agrochemical candidates containing halogen substituents represent novel classes of chemical compounds with new modes of action. However, the complex structure-activity relationships associated with biologically active molecules mean that the introduction of halogens can lead to either an increase or a decrease in the efficacy of a compound, depending on its changed mode of action, physicochemical properties, target interaction or metabolic susceptibility and transformation. In spite of modern design concepts, it is still difficult to predict the sites in a molecule at which halogen substitution will result in optimal desired effects. This review describes comprehensively the successful utilisation of halogens and their unique role in the design of modern agrochemicals, exemplified by various commercial products from Bayer CropScience coming from different agrochemical areas.

Transition from the Lactational Amenorrhea Method to other modern family planning methods in rural Bangladesh: barrier analysis and implications for behavior change communication program intervention design.

PubMed

Kouyaté, Robin Anthony; Ahmed, Salahuddin; Haver, Jaime; McKaig, Catharine; Akter, Nargis; Nash-Mercado, Angela; Baqui, Abdullah

2015-06-01

The timely transition from Lactational Amenorrhea Method (LAM)(2) to another modern family planning method contributes to healthy spacing of pregnancies by increasing the adoption of family planning during the first year postpartum. Yet, literature suggests challenges in completing a timely LAM transition. To guide program implementation in Bangladesh, this study identified factors influencing women's transition decisions. Eighty postpartum women, comprising 40 who transitioned from LAM(3) and 40 who did not,(4) participated. Half of each group participated in in-depth interviews to explore the decision-making process. All participants responded to a "Barrier Analysis" questionnaire to identify differences in eight behavioral determinants. More than half of transitioners switched to another modern method before or within the same month that LAM ended. Of the 18 transitioners who delayed,(5) 15 waited for menses to return. For non-transitioners, key barriers included waiting for menses to return, misconceptions on return to fertility, and perceived lack of familial support. The LAM transition can help women prevent unintended pregnancy during the first year postpartum. Increased emphasis on counseling women about the risk of pregnancy, and misconceptions about personal fertility patterns are critical for facilitating the transition. Strategies should also include interventions that train health workers and improve social support. Copyright © 2015. Published by Elsevier Ltd.

M ssbauer spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hermann, Raphael P

2017-01-01

This most comprehensive and unrivaled compendium in the field provides an up-to-date account of the chemistry of solids, nanoparticles and hybrid materials. Following a valuable introductory chapter reviewing important synthesis techniques, the handbook presents a series of contributions by about 150 international leading experts -- the "Who's Who" of solid state science. Clearly structured, in six volumes it collates the knowledge available on solid state chemistry, starting from the synthesis, and modern methods of structure determination. Understanding and measuring the physical properties of bulk solids and the theoretical basis of modern computational treatments of solids are given ample space, asmore » are such modern trends as nanoparticles, surface properties and heterogeneous catalysis. Emphasis is placed throughout not only on the design and structure of solids but also on practical applications of these novel materials in real chemical situations.« less

Practical optimal flight control system design for helicopter aircraft. Volume 2: Software user's guide

NASA Technical Reports Server (NTRS)

Riedel, S. A.

1979-01-01

A method by which modern and classical control theory techniques may be integrated in a synergistic fashion and used in the design of practical flight control systems is presented. A general procedure is developed, and several illustrative examples are included. Emphasis is placed not only on the synthesis of the design, but on the assessment of the results as well. The first step is to establish the differences, distinguishing characteristics and connections between the modern and classical control theory approaches. Ultimately, this uncovers a relationship between bandwidth goals familiar in classical control and cost function weights in the equivalent optimal system. In order to obtain a practical optimal solution, it is also necessary to formulate the problem very carefully, and each choice of state, measurement and output variable must be judiciously considered. Once design goals are established and problem formulation completed, the control system is synthesized in a straightforward manner. Three steps are involved: filter-observer solution, regulator solution, and the combination of those two into the controller. Assessment of the controller permits and examination and expansion of the synthesis results.

American Modern Design for a New Age.

ERIC Educational Resources Information Center

Johnson, Mark M.

2000-01-01

Focuses on the exhibition titled "American Modern, 1925-1940: Design for a New Age" that documents the efforts and achievements of the United States in the area of design arts. States that the exhibition features more than 150 objects, including furniture, posters, and radios, by leading designers of the early and mid century. (CMK)

A theoretical treatment of technical risk in modern propulsion system design

NASA Astrophysics Data System (ADS)

Roth, Bryce Alexander

2000-09-01

A prevalent trend in modern aerospace systems is increasing complexity and cost, which in turn drives increased risk. Consequently, there is a clear and present need for the development of formalized methods to analyze the impact of risk on the design of aerospace vehicles. The objective of this work is to develop such a method that enables analysis of risk via a consistent, comprehensive treatment of aerothermodynamic and mass properties aspects of vehicle design. The key elements enabling the creation of this methodology are recent developments in the analytical estimation of work potential based on the second law of thermodynamics. This dissertation develops the theoretical foundation of a vehicle analysis method based on work potential and validates it using the Northrop F-5E with GE J85-GE-21 engines as a case study. Although the method is broadly applicable, emphasis is given to aircraft propulsion applications. Three work potential figures of merit are applied using this method: exergy, available energy, and thrust work potential. It is shown that each possesses unique properties making them useful for specific vehicle analysis tasks, though the latter two are actually special cases of exergy. All three are demonstrated on the analysis of the J85-GE-21 propulsion system, resulting in a comprehensive description of propulsion system thermodynamic loss. This "loss management" method is used to analyze aerodynamic drag loss of the F-5E and is then used in conjunction with the propulsive loss model to analyze the usage of fuel work potential throughout the F-5E design mission. The results clearly show how and where work potential is used during flight and yield considerable insight as to where the greatest opportunity for design improvement is. Next, usage of work potential is translated into fuel weight so that the aerothermodynamic performance of the F-5E can be expressed entirely in terms of vehicle gross weight. This technique is then applied as a means to quantify the impact of engine cycle technologies on the F-5E airframe. Finally, loss management methods are used in conjunction with probabilistic analysis methods to quantify the impact of risk on F-5E aerothermodynamic performance.

A Careful Look at Modern Case Selection Methods

ERIC Educational Resources Information Center

Herron, Michael C.; Quinn, Kevin M.

2016-01-01

Case studies appear prominently in political science, sociology, and other social science fields. A scholar employing a case study research design in an effort to estimate causal effects must confront the question, how should cases be selected for analysis? This question is important because the results derived from a case study research program…

Modern Learning Methods for HRD: The Clinical Legal Education (CLE) Approach[C

ERIC Educational Resources Information Center

Wootton, Danielle; Stone, Barras Kenneth

2010-01-01

Purpose: The purpose of this paper is to explore how professional skills training in making ethical decisions for redundancy selection, can be utilised though interactive role play, in a virtual learning environment. Design/methodology/approach: A pilot study was undertaken with a group of part time mature students pursuing a professional…

Micro-Eukaryote Diversity in Freshwater Ponds That Harbor the Amphibian Pathogen "Batrachochytrium Dendrobatidis" ("Bd")

ERIC Educational Resources Information Center

Lauer, Antje; McConnel, Lonnie; Singh, Navdeep

2012-01-01

We designed a microbiology project that fully engaged undergraduate biology students, high school students, and their teachers in a summer research program as part of the Research Education Vitalizing Science University Program conducted at California State University Bakersfield. Modern molecular biological methods and microscopy were used to…

Application of individual behavioral models to predict willingness to use modern contraceptives among pastoralist women in Afar region, Northern Ethiopia.

PubMed

Kahsay, Znabu Hadush; Tegegne, Dessie; Mohammed, Ebrahim; Kiros, Getachew

2018-01-01

Use of modern contraceptive methods reduces the risk of unwanted pregnancy, and is influenced by individual-level factors. Willingness to use modern contraceptive methods maybe a useful metric when considering health outcomes as it could predict health behaviors. Therefore, the current study aimed to assess the willingness of women to use modern contraceptives in Afar pastoralist communities. A community-based cross-sectional study was conducted from May 1 to 30, 2016. Three hundred forty-five women of childbearing age (15-49 years) were systematically sampled with proportionate allocation from seven randomly selected kebeles (neighborhoods) in Aballa District of Afar Region, Ethiopia. All women meeting the inclusion criteria in each selected household were interviewed at home using a semi-structured questionnaire. Construct validity was assured using factor analysis. A combination of individual behavioral models were applied in order to measure willingness to use modern contraceptive methods. Multiple logistic regressions were utilized to identify factors associated with willingness to use contraceptive at P-value of less than 0.05. Three hundred twenty-two women participated in the study, for a response rate of 93.3%. The mean age of respondents was 27 (±6) years. About one-third (N = 106, 32.9%) of the participants reported that they were willing to use modern contraceptives. Orthodox Christians (AOR = 4.22, 95% CI 1.94-8.92), women aged 19 or older at first marriage (AOR = 2.89, 95% CI 1.16-7.23), and women who had never experienced a stillbirth (AOR = 3.85, 95%CI 1.37-10.78) were more likely to report being willing to use modern contraceptives. Additionally, perceived severity of an unwanted pregnancy (AOR = 1.71, 95% CI 1.57-1.93) and perceived self-efficacy to use contraceptives (AOR = 1.26, 95% CI 1.17-1.65) were positively associated with the willingness. Women who had never had an abortion were less likely to express willingness to use modern contraceptives (AOR = 0.41, 95% CI 0.19-0.92) and perceived importance of cultural and religious norms (AOR = 0.85, 95% CI 0.62-0.90) was also negatively associated with willingness. The majority of women in this study were not willing to use modern contraceptive methods. A previous pregnancy outcome of stillbirth was associated with reduced willingness, while a prior abortion was associated with increased willingness. Perceived severity of unwanted pregnancy and higher self-efficacy surrounding contraceptive use were strong predictors of increased willingness to use contraceptives. Religious and cultural norms also appear to influence perception towards modern contraception. Thus, involvement of cultural and religious leaders and consideration of a woman's reproductive history are recommended when designing health education messages on contraception for Afar pastoralist women.

Turbomachinery Airfoil Design Optimization Using Differential Evolution

NASA Technical Reports Server (NTRS)

Madavan, Nateri K.; Biegel, Bryan A. (Technical Monitor)

2002-01-01

An aerodynamic design optimization procedure that is based on a evolutionary algorithm known at Differential Evolution is described. Differential Evolution is a simple, fast, and robust evolutionary strategy that has been proven effective in determining the global optimum for several difficult optimization problems, including highly nonlinear systems with discontinuities and multiple local optima. The method is combined with a Navier-Stokes solver that evaluates the various intermediate designs and provides inputs to the optimization procedure. An efficient constraint handling mechanism is also incorporated. Results are presented for the inverse design of a turbine airfoil from a modern jet engine. The capability of the method to search large design spaces and obtain the optimal airfoils in an automatic fashion is demonstrated. Substantial reductions in the overall computing time requirements are achieved by using the algorithm in conjunction with neural networks.

Development Of A Numerical Tow Tank With Wave Generation To Supplement Experimental Efforts

DTIC Science & Technology

2017-12-01

vehicles CAD computer aided design CFD computational fluid dynamics FVM finite volume method IO information operations ISR intelligence, surveillance, and...deliver a product that I am truly proud of. xv THIS PAGE INTENTIONALLY LEFT BLANK xvi CHAPTER 1: Introduction 1.1 Importance of Tow Tank Testing Modern...wedge installation. 1 In 2016, NPS student Ensign Ryan Tran adapted an existing vertical plunging wedge wave maker design used at the U.S. Naval

Peculiarities of Natural Technology Application in Architecture

NASA Astrophysics Data System (ADS)

Umorina, Z.

2017-11-01

Technical advancement of the modern world has made it possible to create unique artificial objects based on the natural technology principle. New engineering and design types, such as computational design, additive manufacturing, materials engineering, synthetic biology, etc. allow us to enter a new level of interaction between a human being and nature. This influences the formation of a new world view in the sphere of architecture and leads to the development of new methods and styles [1,2].

Diffusion-Driven Charge Transport in Light Emitting Devices

PubMed Central

Oksanen, Jani; Suihkonen, Sami

2017-01-01

Almost all modern inorganic light-emitting diode (LED) designs are based on double heterojunctions (DHJs) whose structure and current injection principle have remained essentially unchanged for decades. Although highly efficient devices based on the DHJ design have been developed and commercialized for energy-efficient general lighting, the conventional DHJ design requires burying the active region (AR) inside a pn-junction. This has hindered the development of emitters utilizing nanostructured ARs located close to device surfaces such as nanowires or surface quantum wells. Modern DHJ III-N LEDs also exhibit resistive losses that arise from the DHJ device geometry. The recently introduced diffusion-driven charge transport (DDCT) emitter design offers a novel way to transport charge carriers to unconventionally placed ARs. In a DDCT device, the AR is located apart from the pn-junction and the charge carriers are injected into the AR by bipolar diffusion. This device design allows the integration of surface ARs to semiconductor LEDs and offers a promising method to reduce resistive losses in high power devices. In this work, we present a review of the recent progress in gallium nitride (GaN) based DDCT devices, and an outlook of potential DDCT has for opto- and microelectronics. PMID:29231900

Parametric geometric model and hydrodynamic shape optimization of a flying-wing structure underwater glider

NASA Astrophysics Data System (ADS)

Wang, Zhen-yu; Yu, Jian-cheng; Zhang, Ai-qun; Wang, Ya-xing; Zhao, Wen-tao

2017-12-01

Combining high precision numerical analysis methods with optimization algorithms to make a systematic exploration of a design space has become an important topic in the modern design methods. During the design process of an underwater glider's flying-wing structure, a surrogate model is introduced to decrease the computation time for a high precision analysis. By these means, the contradiction between precision and efficiency is solved effectively. Based on the parametric geometry modeling, mesh generation and computational fluid dynamics analysis, a surrogate model is constructed by adopting the design of experiment (DOE) theory to solve the multi-objects design optimization problem of the underwater glider. The procedure of a surrogate model construction is presented, and the Gaussian kernel function is specifically discussed. The Particle Swarm Optimization (PSO) algorithm is applied to hydrodynamic design optimization. The hydrodynamic performance of the optimized flying-wing structure underwater glider increases by 9.1%.

Semantics and technologies in modern design of interior stairs

NASA Astrophysics Data System (ADS)

Kukhta, M.; Sokolov, A.; Pelevin, E.

2015-10-01

Use of metal in the design of interior stairs presents new features for shaping, and can be implemented using different technologies. The article discusses the features of design and production technologies of forged metal spiral staircase considering the image semantics based on the historical and cultural heritage. To achieve the objective was applied structural- semantic method (to identify the organization of structure and semantic features of the artistic image), engineering methods (to justify the construction of the object), anthropometry method and ergonomics (to provide usability), methods of comparative analysis (to reveale the features of the way the ladder in different periods of culture). According to the research results are as follows. Was revealed the semantics influence on the design of interior staircase that is based on the World Tree image. Also was suggested rational calculation of steps to ensure the required strength. And finally was presented technology, providing the realization of the artistic image. In the practical part of the work is presented version of forged staircase.

In-line polarization rotator based on the quantum-optical analogy.

PubMed

Chen, Lei; Qu, Ke-Nan; Shen, Heng; Zhang, Wei-Gang; Chou, Keng C; Liu, Qian; Yan, Tie-Yi; Wang, Biao; Wang, Song

2016-05-01

An in-line polarization rotator (PR) is proposed based on the quantum-optical analogy (QOA). The proposed PR possesses an auxiliary E7 liquid crystal (LC) waveguide in the vicinity of the single-mode fiber (SMF) core. Because of the matched core size, the PR demonstrates good compatibility with the established backbone networks which are composed of conventional SMFs. With optimized parameters for the auxiliary waveguide, the PR offers a near 100% polarization conversion efficiency at the 1550 nm band with a bandwidth of ∼30  nm, a length of ∼4625.9  μm with a large tolerance of ∼550  μm, and a tolerance of the input light polarization angle and rotation angle of the E7 LC of ∼π/30 and ∼π/36  rad, respectively. The performance was verified by the full-vector finite-element method. The proposed PR can be easily fabricated based on the existing photonics crystal fiber manufacturing process, making it a potentially inexpensive device for applications in modern communication systems. Moreover, the QOA, compared with the previous supermode-theory design method, allows a designer to consider several waveguides separately. Therefore, various unique characteristics can be met simultaneously which is consistent with the trend of modern fiber design.

Application of laminar flow control to high-bypass-ratio turbofan engine nacelles

NASA Technical Reports Server (NTRS)

Wie, Y. S.; Collier, F. S., Jr.; Wagner, R. D.

1991-01-01

Recently, the concept of the application of hybrid laminar flow to modern commercial transport aircraft was successfully flight tested on a Boeing 757 aircraft. In this limited demonstration, in which only part of the upper surface of the swept wing was designed for the attainment of laminar flow, significant local drag reduction was measured. This paper addresses the potential application of this technology to laminarize the external surface of large, modern turbofan engine nacelles which may comprise as much as 5-10 percent of the total wetted area of future commercial transports. A hybrid-laminar-flow-control (HLFC) pressure distribution is specified and the corresponding nacelle geometry is computed utilizing a predictor/corrector design method. Linear stability calculations are conducted to provide predictions of the extent of the laminar boundary layer. Performance studies are presented to determine potential benefits in terms of reduced fuel consumption.

76 FR 10827 - Modernizing the FCC Form 477 Data Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-28

... Congress, the Commission, other policy makers, and consumers.'' The Commission designed the program as a... Initiative, designed to modernize and streamline how the Commission collects, uses, and disseminates data. As... burden for filers, for example, in the design of the collection or in tools the Commission can provide...

Photovoltaic power system reliability considerations

NASA Technical Reports Server (NTRS)

Lalli, V. R.

1980-01-01

An example of how modern engineering and safety techniques can be used to assure the reliable and safe operation of photovoltaic power systems is presented. This particular application is for a solar cell power system demonstration project designed to provide electric power requirements for remote villages. The techniques utilized involve a definition of the power system natural and operating environment, use of design criteria and analysis techniques, an awareness of potential problems via the inherent reliability and FMEA methods, and use of fail-safe and planned spare parts engineering philosophy.

The Integration Method of Ceramic Arts in the Product Design

NASA Astrophysics Data System (ADS)

Shuxin, Wang

2018-03-01

As one of the four ancient civilization countries, the firing technology of ceramic invented by China has made a great contribution to the progress and development of human society. In modern life, even the development of technology still needs the ceramics, there are large number of artists who take the ceramics as carrier active in the field of contemporary art. The ceramics can be seen everywhere in our daily life, this paper mainly discusses the integration means of ceramic art in the product design.

Missile aerodynamics; Proceedings of the Conference, Monterey, CA, Oct. 31-Nov. 2, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendenhall, M.R.; Nixon, D.; Dillenius, M.F.E.

1989-01-01

The present conference discusses the development status of predictive capabilities for missile aerodynamic characteristics, the application of experimental techniques to missile-release problems, prospective high-performance missile designs, the use of lateral jet controls for missile guidance, and the integration of stores on modern tactical aircraft. Also discussed are semiempirical aerodynamic methods for preliminary design, high angle-of-attack behavior for an advanced missile, and the dynamic derivatives of missiles and fighter-type configurations at high angles-of-attack.

76 FR 62631 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island, SC...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

... incorporate modern methods of measuring ballistic footprints and design criteria for range construction. Since... affected by this regulation. List of Subjects in 33 CFR Part 334 Danger zones, Navigation (water...]21'34'' N, longitude 80[deg]42'48'' W, thence follow the mean high water line southwesterly around...

An Effective Online Teaching Method: The Combination of Collaborative Learning with Initiation and Self-Regulation Learning with Feedback

ERIC Educational Resources Information Center

Tsai, Chia-Wen

2013-01-01

In modern business environments, work and tasks have become more complex and require more interdisciplinary skills to complete, including collaborative and computing skills for website design. However, the computing education in Taiwan can hardly be recognised as effective in developing and transforming students into competitive employees. In this…

A Process for Reviewing and Evaluating Generated Test Items

ERIC Educational Resources Information Center

Gierl, Mark J.; Lai, Hollis

2016-01-01

Testing organization needs large numbers of high-quality items due to the proliferation of alternative test administration methods and modern test designs. But the current demand for items far exceeds the supply. Test items, as they are currently written, evoke a process that is both time-consuming and expensive because each item is written,…

Post-Colonial Science Education: The Challenge of Negotiating Researcher Positioning

ERIC Educational Resources Information Center

Burke, Lydia E. Carol-Ann

2014-01-01

In this paper, I describe a methodology that I employed, and resultant methods that I designed, to facilitate a Critical Discourse Analysis exploring perspectives on Western modern science as a school subject discipline in a given Caribbean context. Using specific themes from post-colonial theory, I sought to engage with some of the viewpoints…

Non-destructive testing method for determining the solvent diffusion coefficient in the porous materials products

NASA Astrophysics Data System (ADS)

Belyaev, V. P.; Mishchenko, S. V.; Belyaev, P. S.

2018-01-01

Ensuring non-destructive testing of products in industry is an urgent task. Most of the modern methods for determining the diffusion coefficient in porous materials have been developed for bodies of a given configuration and size. This leads to the need for finished products destruction to make experimental samples from them. The purpose of this study is the development of a dynamic method that allows operatively determine the diffusion coefficient in finished products from porous materials without destroying them. The method is designed to investigate the solvents diffusion coefficient in building constructions from materials having a porous structure: brick, concrete and aerated concrete, gypsum, cement, gypsum or silicate solutions, gas silicate blocks, heat insulators, etc. A mathematical model of the method is constructed. The influence of the design and measuring device operating parameters on the method accuracy is studied. The application results of the developed method for structural porous products are presented.

Adjoint-Based Aerodynamic Design of Complex Aerospace Configurations

NASA Technical Reports Server (NTRS)

Nielsen, Eric J.

2016-01-01

An overview of twenty years of adjoint-based aerodynamic design research at NASA Langley Research Center is presented. Adjoint-based algorithms provide a powerful tool for efficient sensitivity analysis of complex large-scale computational fluid dynamics (CFD) simulations. Unlike alternative approaches for which computational expense generally scales with the number of design parameters, adjoint techniques yield sensitivity derivatives of a simulation output with respect to all input parameters at the cost of a single additional simulation. With modern large-scale CFD applications often requiring millions of compute hours for a single analysis, the efficiency afforded by adjoint methods is critical in realizing a computationally tractable design optimization capability for such applications.

Efficient Parameter Searches for Colloidal Materials Design with Digital Alchemy

NASA Astrophysics Data System (ADS)

Dodd, Paul, M.; Geng, Yina; van Anders, Greg; Glotzer, Sharon C.

Optimal colloidal materials design is challenging, even for high-throughput or genomic approaches, because the design space provided by modern colloid synthesis techniques can easily have dozens of dimensions. In this talk we present the methodology of an inverse approach we term ''digital alchemy'' to perform rapid searches of design-paramenter spaces with up to 188 dimensions that yield thermodynamically optimal colloid parameters for target crystal structures with up to 20 particles in a unit cell. The method relies only on fundamental principles of statistical mechanics and Metropolis Monte Carlo techniques, and yields particle attribute tolerances via analogues of familiar stress-strain relationships.

Concepts for the development of light-weight composite structures for rotor burst containment

NASA Technical Reports Server (NTRS)

Holms, A. G.

1977-01-01

Published results on rotor burst containment with single materials, and on body armor using composite materials were used to establish a set of hypotheses about what variables might control the design of a weight-efficient protective device. Based on modern concepts for the design and analysis of small optimum seeking experiments, a particular experiment for evaluating the hypotheses and materials was designed. The design and methods for the analysis of results are described. The consequence of such hypotheses is that the device should consist of as many as four concentric rings, each to consist of a material uniquely chosen for its position in the penetration sequence.

Advanced nanomaterials

NASA Astrophysics Data System (ADS)

Titus, Elby; Ventura, João; Pedro Araújo, João; Campos Gil, João

2017-12-01

Nanomaterials provide a remarkably novel outlook to the design and fabrication of materials. The know-how of designing, modelling and fabrication of nanomaterials demands sophisticated experimental and analytical techniques. The major impact of nanomaterials will be in the fields of electronics, energy and medicine. Nanoelectronics hold the promise of improving the quality of life of electronic devices through superior performance, weight reduction and lower power consumption. New energy production systems based on hydrogen, solar and nuclear sources have also benefited immensely from nanomaterials. In modern medicine, nanomaterials research will have great impact on public health care due to better diagnostic methods and design of novel drugs.

Hybrid PV/diesel solar power system design using multi-level factor analysis optimization

NASA Astrophysics Data System (ADS)

Drake, Joshua P.

Solar power systems represent a large area of interest across a spectrum of organizations at a global level. It was determined that a clear understanding of current state of the art software and design methods, as well as optimization methods, could be used to improve the design methodology. Solar power design literature was researched for an in depth understanding of solar power system design methods and algorithms. Multiple software packages for the design and optimization of solar power systems were analyzed for a critical understanding of their design workflow. In addition, several methods of optimization were studied, including brute force, Pareto analysis, Monte Carlo, linear and nonlinear programming, and multi-way factor analysis. Factor analysis was selected as the most efficient optimization method for engineering design as it applied to solar power system design. The solar power design algorithms, software work flow analysis, and factor analysis optimization were combined to develop a solar power system design optimization software package called FireDrake. This software was used for the design of multiple solar power systems in conjunction with an energy audit case study performed in seven Tibetan refugee camps located in Mainpat, India. A report of solar system designs for the camps, as well as a proposed schedule for future installations was generated. It was determined that there were several improvements that could be made to the state of the art in modern solar power system design, though the complexity of current applications is significant.

Development of control system of coating of rod hydraulic cylinders

NASA Astrophysics Data System (ADS)

Aizhambaeva, S. Zh; Maximova, A. V.

2018-01-01

In this article, requirements to materials of hydraulic cylinders and methods of eliminating the main factors affecting the quality of the applied coatings rod hydraulic cylinders. The chromium plating process - one of ways of increase of anti-friction properties of coatings rods, stability to the wear and corrosion. The article gives description of differences of the stand-speed chromium plating process from other types of chromium plating that determines a conclusion about cutting time of chromium plating process. Conducting the analysis of technological equipment suggested addressing the modernization of high-speed chromium plating processes by automation and mechanization. Control system developed by design of schematic block diagram of a modernized and stand-speed chromium plating process.

Modern CACSD using the Robust-Control Toolbox

NASA Technical Reports Server (NTRS)

Chiang, Richard Y.; Safonov, Michael G.

1989-01-01

The Robust-Control Toolbox is a collection of 40 M-files which extend the capability of PC/PRO-MATLAB to do modern multivariable robust control system design. Included are robust analysis tools like singular values and structured singular values, robust synthesis tools like continuous/discrete H(exp 2)/H infinity synthesis and Linear Quadratic Gaussian Loop Transfer Recovery methods and a variety of robust model reduction tools such as Hankel approximation, balanced truncation and balanced stochastic truncation, etc. The capabilities of the toolbox are described and illustated with examples to show how easily they can be used in practice. Examples include structured singular value analysis, H infinity loop-shaping and large space structure model reduction.

Singular Optimal Controls of Rocket Motion (Survey)

NASA Astrophysics Data System (ADS)

Kiforenko, B. N.

2017-05-01

Survey of modern state and discussion of problems of the perfection of methods of investigation of variational problems with a focus on mechanics of space flight are presented. The main attention is paid to the enhancement of the methods of solving of variational problems of rocket motion in the gravitational fields, including rocket motion in the atmosphere. These problems are directly connected with the permanently actual problem of the practical astronautics to increase the payload that is orbited by the carrier rockets in the circumplanetary orbits. An analysis of modern approaches to solving the problems of control of rockets and spacecraft motion on the trajectories with singular arcs that are optimal for the motion of the variable mass body in the medium with resistance is given. The presented results for some maneuvers can serve as an information source for decision making on designing promising rocket and space technology

Reduction of external noise of mobile energy facilities by using active noise control system in muffler

NASA Astrophysics Data System (ADS)

Polivaev, O. I.; Kuznetsov, A. N.; Larionov, A. N.; Beliansky, R. G.

2018-03-01

The paper describes a method for the reducing emission of low-frequency noise of modern automotive vehicles into the environment. The importance of reducing the external noise of modern mobile energy facilities made in Russia is substantiated. Standard methods for controlling external noise in technology are of low efficiency when low-frequency sound waves are reduced. In this case, it is in the low-frequency zone of the sound range that the main power of the noise emitted by the machinery lies. The most effective way to reduce such sound waves is to use active noise control systems. A design of a muffler using a similar system is presented. This muffler allowed one to reduce the emission of increased noise levels into the environment by 7-11 dB and to increase acoustic comfort at the operator's workplace by 3-5 dB.

Neural data science: accelerating the experiment-analysis-theory cycle in large-scale neuroscience.

PubMed

Paninski, L; Cunningham, J P

2018-06-01

Modern large-scale multineuronal recording methodologies, including multielectrode arrays, calcium imaging, and optogenetic techniques, produce single-neuron resolution data of a magnitude and precision that were the realm of science fiction twenty years ago. The major bottlenecks in systems and circuit neuroscience no longer lie in simply collecting data from large neural populations, but also in understanding this data: developing novel scientific questions, with corresponding analysis techniques and experimental designs to fully harness these new capabilities and meaningfully interrogate these questions. Advances in methods for signal processing, network analysis, dimensionality reduction, and optimal control-developed in lockstep with advances in experimental neurotechnology-promise major breakthroughs in multiple fundamental neuroscience problems. These trends are clear in a broad array of subfields of modern neuroscience; this review focuses on recent advances in methods for analyzing neural time-series data with single-neuronal precision. Copyright © 2018 Elsevier Ltd. All rights reserved.

Working in the global world: looking for more modern workplace overseas

NASA Astrophysics Data System (ADS)

Joko Pitoyo, Agus

2018-04-01

International labor migration overseas is very complex and involves multiple dimensional issues, ranging from economic to social, political, and cultural issues. A very long history migration has affect the live of households which has been dependent very much on it, not only in economic terms but also in broader aspects.This research aim is to understand the history and process of international labor migration from the District of Ponorogo. The research was done using mixed method design, combining quantitative and qualitative approaches. Firstly, a survey was done by involving about a thousand households and followed with qualitative method applying in-depth interviews and FGDs to sub-samples households and some key informants. The results have shown that intergenerational migration has established in Ponogoro. There has been an expansion of destination countries with the establishment of many international migration routes. Migrant workers from Ponorogo have traveled to very distant continents and to more modern countries.

Statistical plant set estimation using Schroeder-phased multisinusoidal input design

NASA Technical Reports Server (NTRS)

Bayard, D. S.

1992-01-01

A frequency domain method is developed for plant set estimation. The estimation of a plant 'set' rather than a point estimate is required to support many methods of modern robust control design. The approach here is based on using a Schroeder-phased multisinusoid input design which has the special property of placing input energy only at the discrete frequency points used in the computation. A detailed analysis of the statistical properties of the frequency domain estimator is given, leading to exact expressions for the probability distribution of the estimation error, and many important properties. It is shown that, for any nominal parametric plant estimate, one can use these results to construct an overbound on the additive uncertainty to any prescribed statistical confidence. The 'soft' bound thus obtained can be used to replace 'hard' bounds presently used in many robust control analysis and synthesis methods.

Understanding low uptake of contraceptives in resource-limited settings: a mixed-methods study in rural Burundi.

PubMed

Ndayizigiye, M; Fawzi, M C Smith; Lively, C Thompson; Ware, N C

2017-03-15

Family planning can reduce deaths, improve health, and facilitate economic development in resource-limited settings. Yet, modern contraceptive methods are often underused. This mixed-methods study, conducted in rural Burundi, sought to explain low uptake of contraceptives by identifying utilization barriers. Results may inform development of family planning interventions in Burundi and elsewhere. We investigated uptake of contraceptives among women of reproductive age in two rural districts of Burundi, using an explanatory sequential, mixed-methods research design. We first assessed availability and utilization rates of modern contraceptives through a facility-based survey in 39 health clinics. Barriers to uptake of contraceptives were then explored through qualitative interviews (N = 10) and focus groups (N = 7). Contraceptives were generally available in the 39 clinics studied, yet uptake of family planning averaged only 2.96%. Greater uptake was positively associated with the number of health professionals engaged and trained in family planning service provision, and with the number of different types of contraceptives available. Four uptake barriers were identified: (1) lack of providers to administer contraception, (2) lack of fit between available and preferred contraceptive methods, (3) a climate of fear surrounding contraceptive use, and (4) provider refusal to offer family planning services. Where resources are scarce, availability of modern contraceptives alone will likely not ensure uptake. Interventions addressing multiple uptake barriers simultaneously have the greatest chance of success. In rural Burundi, examples are community distribution of contraceptive methods, public information campaigns, improved training for health professionals and community health workers, and strengthening of the health infrastructure.

Modern drug discovery technologies: opportunities and challenges in lead discovery.

PubMed

Guido, Rafael V C; Oliva, Glaucius; Andricopulo, Adriano D

2011-12-01

The identification of promising hits and the generation of high quality leads are crucial steps in the early stages of drug discovery projects. The definition and assessment of both chemical and biological space have revitalized the screening process model and emphasized the importance of exploring the intrinsic complementary nature of classical and modern methods in drug research. In this context, the widespread use of combinatorial chemistry and sophisticated screening methods for the discovery of lead compounds has created a large demand for small organic molecules that act on specific drug targets. Modern drug discovery involves the employment of a wide variety of technologies and expertise in multidisciplinary research teams. The synergistic effects between experimental and computational approaches on the selection and optimization of bioactive compounds emphasize the importance of the integration of advanced technologies in drug discovery programs. These technologies (VS, HTS, SBDD, LBDD, QSAR, and so on) are complementary in the sense that they have mutual goals, thereby the combination of both empirical and in silico efforts is feasible at many different levels of lead optimization and new chemical entity (NCE) discovery. This paper provides a brief perspective on the evolution and use of key drug design technologies, highlighting opportunities and challenges.

A concept of technology for freight wagons modernization

NASA Astrophysics Data System (ADS)

Pɫaczek, M.; Wróbel, A.; Buchacz, A.

2016-11-01

Rail transport is a very important part of the modern economy, one of the components determining its dynamic development. It is therefore important to conduct research and taking action aimed at the development and refinement of this branch of industry. Such actions directly translate into an increase in its effectiveness, safety, reduction of burden on the environment and society. Nowadays numerous studies are conducted, aimed at introducing new technologies and solutions, both in terms of railway infrastructure and logistics management systems, as well as in traction vehicles themselves. Introduction of modern technology helps eliminate or reduce nuisance problems associated with the implementation of any kind of transport or the operation of the used technical means. Presented paper concerns an issue of freight wagon modernization using composite materials. It presents a part of a research project that aim is to develop a technology of freight wagons modernization during their periodic repair. The main problem during exploitation of concerned types of freight wagons designed for coal transport is corrosion of the wagon's body shell. The goal of the project is to elongate the period between periodic repairs (by better corrosion protection) and improve conditions of exploitation of modernized freight wagons (for example easier unloading during winter conditions - no freezes of the charge to the freight wagon body shell). One of elements of the project is also to develop a system for diagnosing the technical condition of the modernized shell of wagon body during operation. For this purpose the use of non-destructive testing methods of technical state of constructions will be used, including methods that use the analysis of dynamic response of the object. Application of the composite panels to the freight wagon's body shell was proposed as the solution that can solve mentioned problems during exploitation of freight wagons. The composite panels composed of fiberglass and epoxy resin were proposed. They will be mounted on the body shell using blind rivet nuts. What is more the body shell of the modernized freight wagon will be painted using an anticorrosion agent. The research project is realized by a consortium composed by research units and industry and supported by the Polish National Centre for Research and Development.

A Space for Learning: How Teachers Benefit from Participating in a Professional Community of Space Technology

ERIC Educational Resources Information Center

Mehli, Hanne; Bungum, Berit

2013-01-01

Background: Science teachers need a deep understanding of how science works in modern society. Purpose: This article reports a case study investigating the ways in which a short-term in-service course on a research site of space technology contributes to this understanding. Design and method: The study is performed in three steps: an evaluation…

Enhancing Critical Thinking Skills and Writing Skills through the Variation in Non-Traditional Writing Task

ERIC Educational Resources Information Center

Sinaga, Parlindungan; Feranie, Shelly

2017-01-01

The research aims to identify the impacts of embedding non-traditional writing tasks within the course of modern physics conducted to the students of Physics Education and Physics Study Programs. It employed a quasi-experimental method with the pretest-posttest control group design. The used instruments were tests on conceptual mastery, tests on…

Therapy Dogs in Academic Libraries: A Way to Foster Student Engagement and Mitigate Self-Reported Stress during Finals

ERIC Educational Resources Information Center

Jalongo, Mary Renck; McDevitt, Theresa

2015-01-01

More and more modern academic libraries are turning to student engagement activities designed to welcome students into Academia, join a community of scholars, and avail themselves of the full range of resources and services that a university library can provide. One unusual, but inexpensive and highly effective method of engaging students is…

Optimizing the construction of devices to control inaccesible surfaces - case study

NASA Astrophysics Data System (ADS)

Niţu, E. L.; Costea, A.; Iordache, M. D.; Rizea, A. D.; Babă, Al

2017-10-01

The modern concept for the evolution of manufacturing systems requires multi-criteria optimization of technological processes and equipments, prioritizing associated criteria according to their importance. Technological preparation of the manufacturing can be developed, depending on the volume of production, to the limit of favourable economical effects related to the recovery of the costs for the design and execution of the technological equipment. Devices, as subsystems of the technological system, in the general context of modernization and diversification of machines, tools, semi-finished products and drives, are made in a multitude of constructive variants, which in many cases do not allow their identification, study and improvement. This paper presents a case study in which the multi-criteria analysis of some structures, based on a general optimization method, of novelty character, is used in order to determine the optimal construction variant of a control device. The rational construction of the control device confirms that the optimization method and the proposed calculation methods are correct and determine a different system configuration, new features and functions, and a specific method of working to control inaccessible surfaces.

Post-earthquake traffic capacity of modern bridges in California.

DOT National Transportation Integrated Search

2010-03-01

Evaluation of the capacity of a bridge to carry self-weight and traffic loads after an earthquake is essential for a safe and timely re-opening of the bridge. In California, modern highway bridges designed using the Caltrans Seismic Design Criteria a...

Post-Earthquake Traffic Capacity of Modern Bridges in California

DOT National Transportation Integrated Search

2010-03-01

Evaluation of the capacity of a bridge to carry self-weight and traffic loads after an earthquake is essential for a : safe and timely re-opening of the bridge. In California, modern highway bridges designed using the Caltrans : Seismic Design Criter...

A Principled Approach to the Specification of System Architectures for Space Missions

NASA Technical Reports Server (NTRS)

McKelvin, Mark L. Jr.; Castillo, Robert; Bonanne, Kevin; Bonnici, Michael; Cox, Brian; Gibson, Corrina; Leon, Juan P.; Gomez-Mustafa, Jose; Jimenez, Alejandro; Madni, Azad

2015-01-01

Modern space systems are increasing in complexity and scale at an unprecedented pace. Consequently, innovative methods, processes, and tools are needed to cope with the increasing complexity of architecting these systems. A key systems challenge in practice is the ability to scale processes, methods, and tools used to architect complex space systems. Traditionally, the process for specifying space system architectures has largely relied on capturing the system architecture in informal descriptions that are often embedded within loosely coupled design documents and domain expertise. Such informal descriptions often lead to misunderstandings between design teams, ambiguous specifications, difficulty in maintaining consistency as the architecture evolves throughout the system development life cycle, and costly design iterations. Therefore, traditional methods are becoming increasingly inefficient to cope with ever-increasing system complexity. We apply the principles of component-based design and platform-based design to the development of the system architecture for a practical space system to demonstrate feasibility of our approach using SysML. Our results show that we are able to apply a systematic design method to manage system complexity, thus enabling effective data management, semantic coherence and traceability across different levels of abstraction in the design chain. Just as important, our approach enables interoperability among heterogeneous tools in a concurrent engineering model based design environment.

Early Period of Modern Architecture in Turkey - A Case Study of Eskisehir

NASA Astrophysics Data System (ADS)

Karasozen, Rana

2017-10-01

Modern architecture in the Western World bore fruit at the beginning of the 20th Century in consequence of the process of modernity and seeking of the proper architecture for it. It was formed firstly towards the end of the 1920s. The main reason of this nonsynchronous development was the inadequacy of enlightenment and industrial revolution during the Ottoman Empire and the lack of formation of an intellectual infrastructure which provides the basis of modernity. However, the Ottoman Westernization occurring in the 19th century constituted the foundations of the Republic modernity founded in 1923. The earliest modern architectural designs in Turkey were first practised by European architects after the foundation of the Republic and internalised and practised extensively by the native architects afterwards. The early modern architecture of Turkey, named as “1930s Modernism”, continued until the beginning of the World War II. This period was formed in between the periods of first and second nationalist architecture movements. The early modern architecture period of Turkey was a period which high-quality designs were made. It was practised and internalised not only in big cities such as Ankara and in Istanbul, but also in the medium and small cities of the country. This situation was not just about a formal exception but about the internalisation of modernity by the society. Eskisehir is one of the most important pioneering cities of the Republic period in terms of industrial and educational developments. The earliest modern buildings were built as the public buildings by the state and non-citizen architects in the inadequate conditions of the country in terms of economy and professional people. The earliest modern houses of the city designed by these architects were the prototypes for the later practices which offered the citizens a new lifestyle. The modern houses were the symbols of prestige and status for the owners and the dwellers. The features of early modern buildings of Eskisehir as a medium-size city of Turkey will be examined in this study within the scope of the early modern architectural period of Turkey.

The use of methods of structural optimization at the stage of designing high-rise buildings with steel construction

NASA Astrophysics Data System (ADS)

Vasilkin, Andrey

2018-03-01

The more designing solutions at the search stage for design for high-rise buildings can be synthesized by the engineer, the more likely that the final adopted version will be the most efficient and economical. However, in modern market conditions, taking into account the complexity and responsibility of high-rise buildings the designer does not have the necessary time to develop, analyze and compare any significant number of options. To solve this problem, it is expedient to use the high potential of computer-aided designing. To implement automated search for design solutions, it is proposed to develop the computing facilities, the application of which will significantly increase the productivity of the designer and reduce the complexity of designing. Methods of structural and parametric optimization have been adopted as the basis of the computing facilities. Their efficiency in the synthesis of design solutions is shown, also the schemes, that illustrate and explain the introduction of structural optimization in the traditional design of steel frames, are constructed. To solve the problem of synthesis and comparison of design solutions for steel frames, it is proposed to develop the computing facilities that significantly reduces the complexity of search designing and based on the use of methods of structural and parametric optimization.

[Use of modern contraceptive methods in the Democratic Republic of the Congo: prevalence and barriers in the health zone of Dibindi, Mbuji-Mayi].

PubMed

Ntambue, Abel Mukengeshayi; Tshiala, Rachel Ngalula; Malonga, Françoise Kaj; Ilunga, Tabitha Mpoyi; Kamonayi, Josaphat Mulumba; Kazadi, Simon Tshimankinda; Matungulu, Charles Matungu; Musau, Angel Nkola; Mulamba, Diese; Dramaix-Wilmet, Michèle; Donnen, Philippe

2017-01-01

This study aimed to determine modern contraceptive prevalence and the barriers to using modern contraceptive methods among the couples in Dibindi health zone, Mbuji-Mayi, in the Democratic Republic of the Congo. We conducted a cross-sectional descriptive study from May to June 2015. Nonpregnant married women aged 15-49 years old at the time of the investigation, living in Dibindi health zone for two years and having freely consented to participate in the study were included. Data were collected by open-ended interview of these women. Modern contraceptive prevalence was referred to women who were currently using, at the time of the investigation, modern contraceptives. The comparison between proportions was performed at the significance threshold of 5%. Bonferroni's test was used to compare, two by two, the proportions of barriers to using modern contraceptive methods. Modern contraceptive prevalence in Dibindi was 18.4% in 2015. It was low with regard to family planning services available in this health zone. Several women refused to use modern contraceptive methods despite available information because of their desire for motherhood, religious prohibition, opposition on the part of their husband and fear of side effects. Sufficient client-centered or couple-centered information and family planning information should be strengthened in order to eliminate the false beliefs and to increase the use of modern contraceptive methods.

Potential of agricultural fungicides for antifungal drug discovery.

PubMed

Jampilek, Josef

2016-01-01

While it is true that only a small fraction of fungal species are responsible for human mycoses, the increasing prevalence of fungal diseases has highlighted an urgent need to develop new antifungal drugs, especially for systemic administration. This contribution focuses on the similarities between agricultural fungicides and drugs. Inorganic, organometallic and organic compounds can be found amongst agricultural fungicides. Furthermore, fungicides are designed and developed in a similar fashion to drugs based on similar rules and guidelines, with fungicides also having to meet similar criteria of lead-likeness and/or drug-likeness. Modern approved specific-target fungicides are well-characterized entities with a proposed structure-activity relationships hypothesis and a defined mode of action. Extensive toxicological evaluation, including mammalian toxicology assays, is performed during the whole discovery and development process. Thus modern agrochemical research (design of modern agrochemicals) comes close to drug design, discovery and development. Therefore, modern specific-target fungicides represent excellent lead-like structures/models for novel drug design and development.

Light Water Reactor Sustainability Program Operator Performance Metrics for Control Room Modernization: A Practical Guide for Early Design Evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ronald Boring; Roger Lew; Thomas Ulrich

2014-03-01

As control rooms are modernized with new digital systems at nuclear power plants, it is necessary to evaluate the operator performance using these systems as part of a verification and validation process. There are no standard, predefined metrics available for assessing what is satisfactory operator interaction with new systems, especially during the early design stages of a new system. This report identifies the process and metrics for evaluating human system interfaces as part of control room modernization. The report includes background information on design and evaluation, a thorough discussion of human performance measures, and a practical example of how themore » process and metrics have been used as part of a turbine control system upgrade during the formative stages of design. The process and metrics are geared toward generalizability to other applications and serve as a template for utilities undertaking their own control room modernization activities.« less

Prospects of application of additive technologies for increasing the efficiency of impeller machines

NASA Astrophysics Data System (ADS)

Belova, O. V.; Borisov, Yu. A.

2017-08-01

Impeller machine is a device in which the flow path carries out the supply (or retraction) of mechanical energy to the flow of a working fluid passing through the machine. To increase the efficiency of impeller machines, it is necessary to use design modern technologies, namely the use of numerical methods for conducting research in the field of gas dynamics, as well as additive manufacturing (AM) for the of both prototypes and production model. AM technologies are deservedly rightly called revolutionary because they give unique possibility for manufacturing products, creating perfect forms, both light and durable. The designers face the challenge of developing a new design methodology, since AM allows the use of the concept of "Complexity For Free". The "Complexity For Free" conception is based on: complexity of the form; hierarchical complexity; complexity of the material; functional complexity. The new technical items design method according to a functional principle is also investigated.

Modern Design of Resonant Edge-Slot Array Antennas

NASA Technical Reports Server (NTRS)

Gosselin, R. B.

2006-01-01

Resonant edge-slot (slotted-waveguide) array antennas can now be designed very accurately following a modern computational approach like that followed for some other microwave components. This modern approach makes it possible to design superior antennas at lower cost than was previously possible. Heretofore, the physical and engineering knowledge of resonant edge-slot array antennas had remained immature since they were introduced during World War II. This is because despite their mechanical simplicity, high reliability, and potential for operation with high efficiency, the electromagnetic behavior of resonant edge-slot antennas is very complex. Because engineering design formulas and curves for such antennas are not available in the open literature, designers have been forced to implement iterative processes of fabricating and testing multiple prototypes to derive design databases, each unique for a specific combination of operating frequency and set of waveguide tube dimensions. The expensive, time-consuming nature of these processes has inhibited the use of resonant edge-slot antennas. The present modern approach reduces costs by making it unnecessary to build and test multiple prototypes. As an additional benefit, this approach affords a capability to design an array of slots having different dimensions to taper the antenna illumination to reduce the amplitudes of unwanted side lobes. The heart of the modern approach is the use of the latest commercially available microwave-design software, which implements finite-element models of electromagnetic fields in and around waveguides, antenna elements, and similar components. Instead of building and testing prototypes, one builds a database and constructs design curves from the results of computational simulations for sets of design parameters. The figure shows a resonant edge-slot antenna designed following this approach. Intended for use as part of a radiometer operating at a frequency of 10.7 GHz, this antenna was fabricated from dimensions defined exclusively by results of computational simulations. The final design was found to be well optimized and to yield performance exceeding that initially required.

Design of Orion Soil Impact Study using the Modern Design of Experiments

NASA Technical Reports Server (NTRS)

DeLoach, Richard

2010-01-01

Two conventional One Factor At a Time (OFAT) test matrices under consideration for an Orion Landing System subscale soil impact study are reviewed. Certain weaknesses in the designs, systemic to OFAT experiment designs generally, are identified. An alternative test matrix is proposed that is based in the Modern Design of Experiments (MDOE), which achieves certain synergies by combining the original two test matrices into one. The attendant resource savings are quantified and the impact on uncertainty is discussed.

Determinants of modern family planning use among women of reproductive age in the Nkwanta district of Ghana: a case–control study

PubMed Central

2014-01-01

Background Average contraceptive prevalence rate in the Nkwanta district of Ghana was estimated to be 6.2% relative to the national average at the time, of 19%. While several efforts had been made to improve family planning in the country, the district still had very low use of modern family planning methods. This study sought to determine the factors that influenced modern family planning use in general and specifically, the factors that determined the consistently low use of modern family planning methods in the district. Methods A case–control study was conducted in the Nkwanta district of Ghana to determine socio-economic, socio-cultural and service delivery factors influencing family planning usage. One hundred and thirty cases and 260 controls made up of women aged 15–49 years were interviewed using structured questionnaires. A logistic regression was fitted. Results Awareness and knowledge of modern family planning methods were high among cases and controls (over 90%). Lack of formal education among women, socio-cultural beliefs and spousal communication were found to influence modern family planning use. Furthermore, favourable opening hours of the facilities and distance to health facilities influenced the use of modern contraceptives. Conclusion While modern family planning seemed to be common knowledge among these women, actual use of such contraceptives was limited. There is need to improve use of modern family planning methods in the district. In addition to providing health facilities and consolidating close-to-client service initiatives in the district, policies directed towards improving modern family planning method use need to consider the influence of formal education. Promoting basic education, especially among females, will be a crucial step as the district is faced with high levels of school dropout and illiteracy rates. PMID:25117887

Design of a leak detection device for marine airtight container

NASA Astrophysics Data System (ADS)

Li, Yuan; Zhu, Faxin; Lu, Jinshu; Li, Yule; Wu, Wenfeng; Zhang, Jianwei; Qin, Beichen

2018-04-01

The ship airtight container as the research object, according to the tightness of the traditional detection methods of sealed container from the shortcomings of the design of modern ship sealed container leak detection device based on the requirements of the use of AutoCAD to design a ship leakage detection device using airtight container, and introduces its working principle and main components. Finally, from the aspects of technology, structure, operation and economy, the feasibility analysis of the leak detection device for marine airtight container is designed, and it is concluded that the device has the advantages of simple operation, short detection time, easy maintenance and cost control, and has high feasibility.

The application of probabilistic design theory to high temperature low cycle fatigue

NASA Technical Reports Server (NTRS)

Wirsching, P. H.

1981-01-01

Metal fatigue under stress and thermal cycling is a principal mode of failure in gas turbine engine hot section components such as turbine blades and disks and combustor liners. Designing for fatigue is subject to considerable uncertainty, e.g., scatter in cycles to failure, available fatigue test data and operating environment data, uncertainties in the models used to predict stresses, etc. Methods of analyzing fatigue test data for probabilistic design purposes are summarized. The general strain life as well as homo- and hetero-scedastic models are considered. Modern probabilistic design theory is reviewed and examples are presented which illustrate application to reliability analysis of gas turbine engine components.

Geographical variation and factors influencing modern contraceptive use among married women in Ethiopia: evidence from a national population based survey

PubMed Central

2013-01-01

Background Modern contraceptive use persists to be low in most African countries where fertility, population growth, and unmet need for family planning are high. Though there is an evidence of increased overall contraceptive prevalence, a substantial effort remains behind in Ethiopia. This study aimed to identify factors associated with modern contraceptive use and to examine its geographical variations among 15–49 married women in Ethiopia. Methods We conducted secondary analysis of 10,204 reproductive age women included in the 2011 Ethiopia Demographic and Health Survey (DHS). The survey sample was designed to provide national, urban/rural, and regional representative estimates for key health and demographic indicators. The sample was selected using a two-stage stratified sampling process. Bivariate and multivariate logistic regressions were applied to determine the prevalence of modern contraceptive use and associated factors in Ethiopia. Results Being wealthy, more educated, being employed, higher number of living children, being in a monogamous relationship, attending community conversation, being visited by health worker at home strongly predicted use of modern contraception. While living in rural areas, older age, being in polygamous relationship, and witnessing one’s own child’s death were found negatively influence modern contraceptive use. The spatial analysis of contraceptive use revealed that the central and southwestern parts of the country had higher prevalence of modern contraceptive use than that of the eastern and western parts. Conclusion The findings indicate significant socio-economic, urban–rural and regional variation in modern contraceptive use among reproductive age women in Ethiopia. Strengthening community conversation programs and female education should be given top priority. PMID:24067083

Putting engineering back into protein engineering: bioinformatic approaches to catalyst design.

PubMed

Gustafsson, Claes; Govindarajan, Sridhar; Minshull, Jeremy

2003-08-01

Complex multivariate engineering problems are commonplace and not unique to protein engineering. Mathematical and data-mining tools developed in other fields of engineering have now been applied to analyze sequence-activity relationships of peptides and proteins and to assist in the design of proteins and peptides with specified properties. Decreasing costs of DNA sequencing in conjunction with methods to quickly synthesize statistically representative sets of proteins allow modern heuristic statistics to be applied to protein engineering. This provides an alternative approach to expensive assays or unreliable high-throughput surrogate screens.

The Role of Modern Control Theory in the Design of Controls for Aircraft Turbine Engines

NASA Technical Reports Server (NTRS)

Zeller, J.; Lehtinen, B.; Merrill, W.

1982-01-01

Accomplishments in applying Modern Control Theory to the design of controls for advanced aircraft turbine engines were reviewed. The results of successful research programs are discussed. Ongoing programs as well as planned or recommended future thrusts are also discussed.

Fashion sketch design by interactive genetic algorithms

NASA Astrophysics Data System (ADS)

Mok, P. Y.; Wang, X. X.; Xu, J.; Kwok, Y. L.

2012-11-01

Computer aided design is vitally important for the modern industry, particularly for the creative industry. Fashion industry faced intensive challenges to shorten the product development process. In this paper, a methodology is proposed for sketch design based on interactive genetic algorithms. The sketch design system consists of a sketch design model, a database and a multi-stage sketch design engine. First, a sketch design model is developed based on the knowledge of fashion design to describe fashion product characteristics by using parameters. Second, a database is built based on the proposed sketch design model to define general style elements. Third, a multi-stage sketch design engine is used to construct the design. Moreover, an interactive genetic algorithm (IGA) is used to accelerate the sketch design process. The experimental results have demonstrated that the proposed method is effective in helping laypersons achieve satisfied fashion design sketches.

Design techniques for low-voltage analog integrated circuits

NASA Astrophysics Data System (ADS)

Rakús, Matej; Stopjaková, Viera; Arbet, Daniel

2017-08-01

In this paper, a review and analysis of different design techniques for (ultra) low-voltage integrated circuits (IC) are performed. This analysis shows that the most suitable design methods for low-voltage analog IC design in a standard CMOS process include techniques using bulk-driven MOS transistors, dynamic threshold MOS transistors and MOS transistors operating in weak or moderate inversion regions. The main advantage of such techniques is that there is no need for any modification of standard CMOS structure or process. Basic circuit building blocks like differential amplifiers or current mirrors designed using these approaches are able to operate with the power supply voltage of 600 mV (or even lower), which is the key feature towards integrated systems for modern portable applications.

Aerodynamic Design and Numerical Analysis of Supersonic Turbine for Turbo Pump

NASA Astrophysics Data System (ADS)

Fu, Chao; Zou, Zhengping; Kong, Qingguo; Cheng, Honggui; Zhang, Weihao

2016-09-01

Supersonic turbine is widely used in the turbo pump of modern rocket. A preliminary design method for supersonic turbine has been developed considering the coupling effects of turbine and nozzle. Numerical simulation has been proceeded to validate the feasibility of the design method. As the strong shockwave reflected on the mixing plane, additional numerical simulated error would be produced by the mixing plane model in the steady CFD. So unsteady CFD is employed to investigate the aerodynamic performance of the turbine and flow field in passage. Results showed that the preliminary design method developed in this paper is suitable for designing supersonic turbine. This periodical variation of complex shockwave system influences the development of secondary flow, wake and shock-boundary layer interaction, which obviously affect the secondary loss in vane passage. The periodical variation also influences the strength of reflecting shockwave, which affects the profile loss in vane passage. Besides, high circumferential velocity at vane outlet and short blade lead to high radial pressure gradient, which makes the low kinetic energy fluid moves towards hub region and produces additional loss.

Modern digital flight control system design for VTOL aircraft

NASA Technical Reports Server (NTRS)

Broussard, J. R.; Berry, P. W.; Stengel, R. F.

1979-01-01

Methods for and results from the design and evaluation of a digital flight control system (DFCS) for a CH-47B helicopter are presented. The DFCS employed proportional-integral control logic to provide rapid, precise response to automatic or manual guidance commands while following conventional or spiral-descent approach paths. It contained altitude- and velocity-command modes, and it adapted to varying flight conditions through gain scheduling. Extensive use was made of linear systems analysis techniques. The DFCS was designed, using linear-optimal estimation and control theory, and the effects of gain scheduling are assessed by examination of closed-loop eigenvalues and time responses.

Technical Evaluation Report for Symposium AVT-147: Computational Uncertainty in Military Vehicle Design

NASA Technical Reports Server (NTRS)

Radespiel, Rolf; Hemsch, Michael J.

2007-01-01

The complexity of modern military systems, as well as the cost and difficulty associated with experimentally verifying system and subsystem design makes the use of high-fidelity based simulation a future alternative for design and development. The predictive ability of such simulations such as computational fluid dynamics (CFD) and computational structural mechanics (CSM) have matured significantly. However, for numerical simulations to be used with confidence in design and development, quantitative measures of uncertainty must be available. The AVT 147 Symposium has been established to compile state-of-the art methods of assessing computational uncertainty, to identify future research and development needs associated with these methods, and to present examples of how these needs are being addressed and how the methods are being applied. Papers were solicited that address uncertainty estimation associated with high fidelity, physics-based simulations. The solicitation included papers that identify sources of error and uncertainty in numerical simulation from either the industry perspective or from the disciplinary or cross-disciplinary research perspective. Examples of the industry perspective were to include how computational uncertainty methods are used to reduce system risk in various stages of design or development.

Propagation Impact on Modern HF (High Frequency) Communications System Design

DTIC Science & Technology

1986-03-01

received SNR is maximised and interference avoided. As a general principle, system availability and reliability should be improved by the use of...LECTURE SERIES No. 145 propagation Impact on Modern HF Communications System Design. NORTH ATLANTIC TREATY ORGANIZATION gS ^, DISTRIBUTION ...civil and military communities for high frequency communications. It will discuss concepts of real time channel evaluation , system design, as well as

Design and Implementation of a Modern Automatic Deformation Monitoring System

NASA Astrophysics Data System (ADS)

Engel, Philipp; Schweimler, Björn

2016-03-01

The deformation monitoring of structures and buildings is an important task field of modern engineering surveying, ensuring the standing and reliability of supervised objects over a long period. Several commercial hardware and software solutions for the realization of such monitoring measurements are available on the market. In addition to them, a research team at the University of Applied Sciences in Neubrandenburg (NUAS) is actively developing a software package for monitoring purposes in geodesy and geotechnics, which is distributed under an open source licence and free of charge. The task of managing an open source project is well-known in computer science, but it is fairly new in a geodetic context. This paper contributes to that issue by detailing applications, frameworks, and interfaces for the design and implementation of open hardware and software solutions for sensor control, sensor networks, and data management in automatic deformation monitoring. It will be discussed how the development effort of networked applications can be reduced by using free programming tools, cloud computing technologies, and rapid prototyping methods.

Architecture of high-rise buildings as a brand of the modern Kazakhstan

NASA Astrophysics Data System (ADS)

Abdrassilova, Gulnara; Kozbagarova, Nina; Tuyakayeva, Ainagul

2018-03-01

Using practical examples article reviews urban-planning and space-planning features of design and construction of high-rise buildings in Kazakhstan conditions; methods are identified that provide for structural stability against wind and seismic loads based on innovative technical and technological solutions. Article authors stress out the fashion function of high-rise buildings in the new capital of Kazakhstan, the Astana city.

New Horizons: Designing and Measuring for Modern Learning Environments

ERIC Educational Resources Information Center

Carter, Richard Allen, Jr.

2017-01-01

This dissertation consists of five chapters. The first chapter serves to introduce the Modern Learning Environment (MLE) by discussing the challenges of designing and measuring student performance in these novel environments. Chapter two of the dissertation reviews the current research base of studying self-regulated learning in the modern…

A Squeezed Artificial Neural Network for the Symbolic Network Reliability Functions of Binary-State Networks.

PubMed

Yeh, Wei-Chang

Network reliability is an important index to the provision of useful information for decision support in the modern world. There is always a need to calculate symbolic network reliability functions (SNRFs) due to dynamic and rapid changes in network parameters. In this brief, the proposed squeezed artificial neural network (SqANN) approach uses the Monte Carlo simulation to estimate the corresponding reliability of a given designed matrix from the Box-Behnken design, and then the Taguchi method is implemented to find the appropriate number of neurons and activation functions of the hidden layer and the output layer in ANN to evaluate SNRFs. According to the experimental results of the benchmark networks, the comparison appears to support the superiority of the proposed SqANN method over the traditional ANN-based approach with at least 16.6% improvement in the median absolute deviation in the cost of extra 2 s on average for all experiments.Network reliability is an important index to the provision of useful information for decision support in the modern world. There is always a need to calculate symbolic network reliability functions (SNRFs) due to dynamic and rapid changes in network parameters. In this brief, the proposed squeezed artificial neural network (SqANN) approach uses the Monte Carlo simulation to estimate the corresponding reliability of a given designed matrix from the Box-Behnken design, and then the Taguchi method is implemented to find the appropriate number of neurons and activation functions of the hidden layer and the output layer in ANN to evaluate SNRFs. According to the experimental results of the benchmark networks, the comparison appears to support the superiority of the proposed SqANN method over the traditional ANN-based approach with at least 16.6% improvement in the median absolute deviation in the cost of extra 2 s on average for all experiments.

New quality assurance program integrating "modern radiotherapy" within the German Hodgkin Study Group.

PubMed

Kriz, J; Baues, C; Engenhart-Cabillic, R; Haverkamp, U; Herfarth, K; Lukas, P; Schmidberger, H; Marnitz-Schulze, S; Fuchs, M; Engert, A; Eich, H T

2017-02-01

Field design changed substantially from extended-field RT (EF-RT) to involved-field RT (IF-RT) and now to involved-node RT (IN-RT) and involved-site RT (IS-RT) as well as treatment techniques in radiotherapy (RT) of Hodgkin's lymphoma (HL). The purpose of this article is to demonstrate the establishment of a quality assurance program (QAP) including modern RT techniques and field designs within the German Hodgkin Study Group (GHSG). In the era of modern conformal RT, this QAP had to be fundamentally adapted and a new evaluation process has been intensively discussed by the radiotherapeutic expert panel of the GHSG. The expert panel developed guidelines and criteria to analyse "modern" field designs and treatment techniques. This work is based on a dataset of 11 patients treated within the sixth study generation (HD16-17). To develop a QAP of "modern RT", the expert panel defined criteria for analysing current RT procedures. The consensus of a modified QAP in ongoing and future trials is presented. With this schedule, the QAP of the GHSG could serve as a model for other study groups.

Cadastral Positioning Accuracy Improvement: a Case Study in Malaysia

NASA Astrophysics Data System (ADS)

Hashim, N. M.; Omar, A. H.; Omar, K. M.; Abdullah, N. M.; Yatim, M. H. M.

2016-09-01

Cadastral map is a parcel-based information which is specifically designed to define the limitation of boundaries. In Malaysia, the cadastral map is under authority of the Department of Surveying and Mapping Malaysia (DSMM). With the growth of spatial based technology especially Geographical Information System (GIS), DSMM decided to modernize and reform its cadastral legacy datasets by generating an accurate digital based representation of cadastral parcels. These legacy databases usually are derived from paper parcel maps known as certified plan. The cadastral modernization will result in the new cadastral database no longer being based on single and static parcel paper maps, but on a global digital map. Despite the strict process of the cadastral modernization, this reform has raised unexpected queries that remain essential to be addressed. The main focus of this study is to review the issues that have been generated by this transition. The transformed cadastral database should be additionally treated to minimize inherent errors and to fit them to the new satellite based coordinate system with high positional accuracy. This review result will be applied as a foundation for investigation to study the systematic and effectiveness method for Positional Accuracy Improvement (PAI) in cadastral database modernization.

Manual: Modern Gum Naval Stores Methods

Treesearch

Ralph W. Clements

1974-01-01

Modern gum naval stores methods have been developed to benefit both the gum producer and the timber owner. Following the methods described in this booklet will bring maximum gum yields, whill reduce chipping-labor requirements about 50 percent, and will make the worked-out tree saleable for other wood products. If these modern turpentining mehods are used, naval...

PLASMA-field barrier sentry (PFBS)

NASA Astrophysics Data System (ADS)

Gonzaga, Ernesto A.; Cossette, Harold James

2013-06-01

This paper describes the concept and method in designing and developing a unique security system apparatus that will counter unauthorized personnel: to deny access to or occupy an area or facility, to control or direct crowd or large groups, and to incapacitate individuals or small groups until they can be secured by military or law enforcement personnel. The system exploits Tesla coil technology. Application of basic engineering circuit analysis and principle is demonstrated. Transformation from classical spark gap method to modern solid state design was presented. The analysis shows how the optimum design can be implemented to maximize performance of the apparatus. Discussion of the hazardous effects of electrical elements to human physiological conditions was covered. This serves to define guidelines in implementing safety limits and precautions on the performance of the system. The project is strictly adhering towards non-lethal technologies and systems.

Comparison and analysis of two modern methods in the structural health monitoring techniques in aerospace

NASA Astrophysics Data System (ADS)

Riahi, Mohammad; Ahmadi, Alireza

2016-04-01

Role of air transport in the development and expansion of world trade leading to economic growth of different countries is undeniable. Continuing the world's trade sustainability without expansion of aerospace is next to impossible. Based on enormous expenses for design, manufacturing and maintenance of different aerospace structures, correct and timely diagnosis of defects in those structures to provide for maximum safety has the highest importance. Amid all this, manufacturers of commercial and even military aircrafts are after production of less expensive, lighter, higher fuel economy and nonetheless, higher safety. As such, two events has prevailed in the aerospace industries: (1) Utilization of composites for the fuselage as well as other airplane parts, (2) using modern manufacturing methods. Arrival of two these points have created the need for upgrading of the present systems as well as innovating newer methods in diagnosing and detection of defects in aerospace structures. Despite applicability of nondestructive testing (NDT) methods in aerospace for decades, due to some limitations in the defect detection's certainty, particularly for composite material and complex geometries, shadow of doubt has fallen on maintaining complete confidence in using NDT. These days, two principal approach are ahead to tackle the above mentioned problems. First, approach for the short range is the creative and combinational mean to increase the reliability of NDT and for the long run, innovation of new methods on the basis of structural health monitoring (SHM) is in order. This has led to new philosophy in the maintenance area and in some instances; field of design has also been affected by it.

The chaotic dynamical aperture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, S.Y.; Tepikian, S.

1985-10-01

Nonlinear magnetic forces become more important for particles in the modern large accelerators. These nonlinear elements are introduced either intentionally to control beam dynamics or by uncontrollable random errors. Equations of motion in the nonlinear Hamiltonian are usually non-integrable. Because of the nonlinear part of the Hamiltonian, the tune diagram of accelerators is a jungle. Nonlinear magnet multipoles are important in keeping the accelerator operation point in the safe quarter of the hostile jungle of resonant tunes. Indeed, all the modern accelerator design have taken advantages of nonlinear mechanics. On the other hand, the effect of the uncontrollable random multipolesmore » should be evaluated carefully. A powerful method of studying the effect of these nonlinear multipoles is using a particle tracking calculation, where a group of test particles are tracing through these magnetic multipoles in the accelerator hundreds to millions of turns in order to test the dynamical aperture of the machine. These methods are extremely useful in the design of a large accelerator such as SSC, LEP, HERA and RHIC. These calculations unfortunately take tremendous amount of computing time. In this paper, we try to apply the existing method in the nonlinear dynamics to study the possible alternative solution. When the Hamiltonian motion becomes chaotic, the tune of the machine becomes undefined. The aperture related to the chaotic orbit can be identified as chaotic dynamical aperture. We review the method of determining chaotic orbit and apply the method to nonlinear problems in accelerator physics. We then discuss the scaling properties and effect of random sextupoles.« less

Optical design and evaluation of a 4 mm cost-effective ultra-high-definition arthroscope.

PubMed

Cheng, Dewen; Wang, Yongtian; Yu, Lu; Liu, Xiaohua

2014-08-01

High definition and magnification rigid endoscope plays an important role in modern minimally invasive medical surgery and diagnosis. In this paper, we present the design and evaluation methods of a high definition rigid endoscope, specifically an arthroscope, with a large depth of field (DOF). The incident heights and exit angles of the sampled rays on the relay lens are controlled during the optimization process to ensure an effective field view (70°) and a normal ray path within the limited lens diameter of 2.7 mm. The lens is set up as a multi-configuration system with two extreme and one middle object distances to cover a large DOF. As a result, an entrance pupil of 0.3 mm is achieved for the first time, to bring the theoretical resolution to 23.1 lps/mm in the object space at a working distance of 20 mm, with the wavelength of 0.532 um. The modulation transfer function (MTF) curves approach diffraction limit, and the values are all higher than 0.3 at 160 line pairs/mm (lps/mm) in the image space. Meanwhile, stray light caused by total internal reflection on the inner wall of the rod lenses and the objective lens is eliminated. The measured resolution in the object space at a 20 mm working distance is 22.3 lps/mm, and test results show that other performance characteristics also fulfill design requirements. The relay lenses are designed with only one type of the spacer and two types of lenses to greatly reduce the fabrication and assembly cost. The design method has important research and application values for lens systems used in modern minimally invasive medical surgery and industrial non-destructive testing area.

A Meta-heuristic Approach for Variants of VRP in Terms of Generalized Saving Method

NASA Astrophysics Data System (ADS)

Shimizu, Yoshiaki

Global logistic design is becoming a keen interest to provide an essential infrastructure associated with modern societal provision. For examples, we can designate green and/or robust logistics in transportation systems, smart grids in electricity utilization systems, and qualified service in delivery systems, and so on. As a key technology for such deployments, we engaged in practical vehicle routing problem on a basis of the conventional saving method. This paper extends such idea and gives a general framework available for various real-world applications. It can cover not only delivery problems but also two kind of pick-up problems, i.e., straight and drop-by routings. Moreover, multi-depot problem is considered by a hybrid approach with graph algorithm and its solution method is realized in a hierarchical manner. Numerical experiments have been taken place to validate effectiveness of the proposed method.

Determinants of modern family planning use among women of reproductive age in the Nkwanta district of Ghana: a case-control study.

PubMed

Eliason, Sebastian; Awoonor-Williams, John K; Eliason, Cecilia; Novignon, Jacob; Nonvignon, Justice; Aikins, Moses

2014-08-13

Average contraceptive prevalence rate in the Nkwanta district of Ghana was estimated to be 6.2% relative to the national average at the time, of 19%. While several efforts had been made to improve family planning in the country, the district still had very low use of modern family planning methods. This study sought to determine the factors that influenced modern family planning use in general and specifically, the factors that determined the consistently low use of modern family planning methods in the district. A case-control study was conducted in the Nkwanta district of Ghana to determine socio-economic, socio-cultural and service delivery factors influencing family planning usage. One hundred and thirty cases and 260 controls made up of women aged 15-49 years were interviewed using structured questionnaires. A logistic regression was fitted. Awareness and knowledge of modern family planning methods were high among cases and controls (over 90%). Lack of formal education among women, socio-cultural beliefs and spousal communication were found to influence modern family planning use. Furthermore, favourable opening hours of the facilities and distance to health facilities influenced the use of modern contraceptives. While modern family planning seemed to be common knowledge among these women, actual use of such contraceptives was limited. There is need to improve use of modern family planning methods in the district. In addition to providing health facilities and consolidating close-to-client service initiatives in the district, policies directed towards improving modern family planning method use need to consider the influence of formal education. Promoting basic education, especially among females, will be a crucial step as the district is faced with high levels of school dropout and illiteracy rates.

Modern contraceptive utilization and associated factors among married pastoralist women in Bale eco-region, Bale Zone, South East Ethiopia.

PubMed

Belda, Semere Sileshi; Haile, Mekonnen Tegegne; Melku, Abulie Takele; Tololu, Abdurehaman Kalu

2017-03-14

Women who live in remote rural areas encounter different challenges against contraception and often deny the use of modern contraceptive methods. The predictors of modern contraceptive utilization by pastoralist women in the Bale eco-region could be specific and are not well known. Therefore, this study aims to assess modern contraceptive utilization and its determinants among married pastoralist women in Bale eco-region, Oromia regional state, South East Ethiopia. A community-based cross-sectional study was conducted from 20th November 2015 to 30th February 2016. A structured questionnaire was used to interview 549 married pastoralist women who were selected by multistage sampling technique. The data were analyzed by SPSS - 21 software, multivariate logistic regression analysis was used to identify predictors of modern contraceptive use at (P-value <0.05), and odds ratios with 95% confidence interval were used to assess the strength of associations between variables. The current modern contraceptive method use by married pastoralist women was (20.8%). Among the total users, (78.1%) use the injectable method. The common reasons for non-use of modern contraceptive methods includes: religious-opposition (55.9%), desire for more children (28.3%), fear of side effects (25.5%), and husband's opposition (17.5%). Couple discussion (AOR = 4.63, 95%CI: 2.15, 9.98), perceived husband's approval (AOR = 8.00, 95% CI: 3.52, 18.19), discussion with health extension worker (AOR = 5.99, 95% CI: 1.81, 19.85), and perceived cultural acceptability (AOR = 2.10, 95% CI: 1.09, 4.03) were the independent predictors of modern contraceptive use by married pastoralist women in Bale eco-region. The study identified lower modern contraceptive method utilization by pastoralist women, and the majority of the contraceptive users rely on short- acting contraceptive methods. The uncomplimentary perceptions towards religious and cultural acceptability of modern contraceptive method were among the major reasons for lesser utilization of the methods. Family planning programs should be tailored to actively involve pastoralist women, husbands, and religious leaders in pastoralist communities.

Curriculum Designed for an Equitable Pedagogy

ERIC Educational Resources Information Center

Cullen, Roxanne; Hill, Reinhold R.

2013-01-01

Rather than viewing curriculum as linear, a post-modern, learner-centered curriculum design is a spiral or recursive curriculum. Post-modernism provides a much less stable foundation upon which to build a model of student learning, a model that recognizes and even celebrates individual difference and one that is supported by research on how people…

77 FR 38377 - Notice of Availability of the Draft Environmental Impact Statement: Los Angeles County, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... modernize the design at the I-405, SR-91 and a portion of the I-5 interchanges, modernize and reconfigure... Intelligent Transportation Systems (ITS) improvements; improvements to 42 local arterial intersections within the I-710 Corridor; aesthetic enhancements; and, drainage and water quality improvement design...

Advanced Recording and Preprocessing of Physiological Signals. [data processing equipment for flow measurement of blood flow by ultrasonics

NASA Technical Reports Server (NTRS)

Bentley, P. B.

1975-01-01

The measurement of the volume flow-rate of blood in an artery or vein requires both an estimate of the flow velocity and its spatial distribution and the corresponding cross-sectional area. Transcutaneous measurements of these parameters can be performed using ultrasonic techniques that are analogous to the measurement of moving objects by use of a radar. Modern digital data recording and preprocessing methods were applied to the measurement of blood-flow velocity by means of the CW Doppler ultrasonic technique. Only the average flow velocity was measured and no distribution or size information was obtained. Evaluations of current flowmeter design and performance, ultrasonic transducer fabrication methods, and other related items are given. The main thrust was the development of effective data-handling and processing methods by application of modern digital techniques. The evaluation resulted in useful improvements in both the flowmeter instrumentation and the ultrasonic transducers. Effective digital processing algorithms that provided enhanced blood-flow measurement accuracy and sensitivity were developed. Block diagrams illustrative of the equipment setup are included.

Specification and Design of Electrical Flight System Architectures with SysML

NASA Technical Reports Server (NTRS)

McKelvin, Mark L., Jr.; Jimenez, Alejandro

2012-01-01

Modern space flight systems are required to perform more complex functions than previous generations to support space missions. This demand is driving the trend to deploy more electronics to realize system functionality. The traditional approach for the specification, design, and deployment of electrical system architectures in space flight systems includes the use of informal definitions and descriptions that are often embedded within loosely coupled but highly interdependent design documents. Traditional methods become inefficient to cope with increasing system complexity, evolving requirements, and the ability to meet project budget and time constraints. Thus, there is a need for more rigorous methods to capture the relevant information about the electrical system architecture as the design evolves. In this work, we propose a model-centric approach to support the specification and design of electrical flight system architectures using the System Modeling Language (SysML). In our approach, we develop a domain specific language for specifying electrical system architectures, and we propose a design flow for the specification and design of electrical interfaces. Our approach is applied to a practical flight system.

MPACT Standard Input User s Manual, Version 2.2.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, Benjamin S.; Downar, Thomas; Fitzgerald, Andrew

The MPACT (Michigan PArallel Charactistics based Transport) code is designed to perform high-fidelity light water reactor (LWR) analysis using whole-core pin-resolved neutron transport calculations on modern parallel-computing hardware. The code consists of several libraries which provide the functionality necessary to solve steady-state eigenvalue problems. Several transport capabilities are available within MPACT including both 2-D and 3-D Method of Characteristics (MOC). A three-dimensional whole core solution based on the 2D-1D solution method provides the capability for full core depletion calculations.

Studies of The Durability of Belt Conveyor Idlers with Working Loads Taken into Account

NASA Astrophysics Data System (ADS)

Król, Robert

2017-12-01

The results of laboratory and operational studies conducted in the Machinery Systems Division of Wroclaw University of Technology in recent years have became the basis for selecting proper belt conveyor roller designs optimized for specific strength and operational criteria. The usefulness of the results for assessing the energy intensity of idlers, estimating their durability and determining modernization policies has been confirmed. Methods of estimating the durability of carrying idlers on the basis of the identified output stream distributions are presented. Results of studies carried out using an analytical method and a laboratory method are reported. It has been shown that the operational durability of a roller is determined by its design, the roller set parameters (the spacing and the angle of bevel) and the operating conditions having a bearing on the irregularity of the transported output stream.

Multinational Corporations, Democracy and Child Mortality: A Quantitative, Cross-National Analysis of Developing Countries

ERIC Educational Resources Information Center

Shandra, John M.; Nobles, Jenna E.; London, Bruce; Williamson, John B.

2005-01-01

This study presents quantitative, sociological models designed to account for cross-national variation in child mortality. We consider variables linked to five different theoretical perspectives that include the economic modernization, social modernization, political modernization, ecological-evolutionary, and dependency perspectives. The study is…

Formal design specification of a Processor Interface Unit

NASA Technical Reports Server (NTRS)

Fura, David A.; Windley, Phillip J.; Cohen, Gerald C.

1992-01-01

This report describes work to formally specify the requirements and design of a processor interface unit (PIU), a single-chip subsystem providing memory-interface bus-interface, and additional support services for a commercial microprocessor within a fault-tolerant computer system. This system, the Fault-Tolerant Embedded Processor (FTEP), is targeted towards applications in avionics and space requiring extremely high levels of mission reliability, extended maintenance-free operation, or both. The need for high-quality design assurance in such applications is an undisputed fact, given the disastrous consequences that even a single design flaw can produce. Thus, the further development and application of formal methods to fault-tolerant systems is of critical importance as these systems see increasing use in modern society.

A Comparison of Two Balance Calibration Model Building Methods

NASA Technical Reports Server (NTRS)

DeLoach, Richard; Ulbrich, Norbert

2007-01-01

Simulated strain-gage balance calibration data is used to compare the accuracy of two balance calibration model building methods for different noise environments and calibration experiment designs. The first building method obtains a math model for the analysis of balance calibration data after applying a candidate math model search algorithm to the calibration data set. The second building method uses stepwise regression analysis in order to construct a model for the analysis. Four balance calibration data sets were simulated in order to compare the accuracy of the two math model building methods. The simulated data sets were prepared using the traditional One Factor At a Time (OFAT) technique and the Modern Design of Experiments (MDOE) approach. Random and systematic errors were introduced in the simulated calibration data sets in order to study their influence on the math model building methods. Residuals of the fitted calibration responses and other statistical metrics were compared in order to evaluate the calibration models developed with different combinations of noise environment, experiment design, and model building method. Overall, predicted math models and residuals of both math model building methods show very good agreement. Significant differences in model quality were attributable to noise environment, experiment design, and their interaction. Generally, the addition of systematic error significantly degraded the quality of calibration models developed from OFAT data by either method, but MDOE experiment designs were more robust with respect to the introduction of a systematic component of the unexplained variance.

Database Design and Management in Engineering Optimization.

DTIC Science & Technology

1988-02-01

scientific and engineer- Q.- ’ method In the mid-19SOs along with modern digital com- ing applications. The paper highlights the difference puters, have made...is continuously tion software can call standard subroutines from the DBMS redefined in an application program, DDL must have j libary to define...operations. .. " type data usually encountered in engineering applications. GFDGT: Computes the number of digits needed to display " "’ A user

High Bypass Turbofan Component Development. Phase II. Detailed Design.

DTIC Science & Technology

1979-08-01

Selecting Blade Thickness for Bird Strike 46 27. Method for Selecting Blade Airfoil Attachment 49 AIRCRAF ENGINE GROUP IV GENERAL ELECTRIC COMPANY...reserves, the replacement aircraft must have a fuel efficient engine as the propulsion system, i. e., * modern turbofan engine . Technology in the large... turbofan engines has been well demonstrated, but little has been done in the size applicable to a twin- engine primary trainer aircraft . Today, there is

A Study on the Campus Landscape Design of the National University of Singapore

NASA Astrophysics Data System (ADS)

Lin, Lusheng; Dong, Ya

2018-01-01

In this paper, we analyzed the functions, structure, layout, landscape and engineering measure of the campus of NUS by the way of such research methods as present situation research, interview and comparative study. And we get the spatial characteristics of landscape environment affected by political economy, human geography, geographical conditions which will provide a new perspective for building international, modern, high-level research universities.

Designing the accident and emergency system: lessons from manufacturing

PubMed Central

Walley, P

2003-01-01

Objectives: To review the literature on manufacturing process design and demonstrate applicability in health care. Methods: Literature review and application of theory using two years activity data from two healthcare communities and extensive observation of activities over a six week period by seven researchers. Results: It was possible to identify patient flows that could be used to design treatment processes around the needs of the patient. Some queues are built into existing treatment processes and can be removed by better process design. Capacity imbalance, not capacity shortage, causes some unnecessary waiting in accident and emergency departments. Conclusions: Clinicians would find that modern manufacturing theories produce more acceptable designs of systems. In particular, good quality is seen as a necessary pre-requisite of fast, efficient services. PMID:12642523

A Single-Vector Force Calibration Method Featuring the Modern Design of Experiments

NASA Technical Reports Server (NTRS)

Parker, P. A.; Morton, M.; Draper, N.; Line, W.

2001-01-01

This paper proposes a new concept in force balance calibration. An overview of the state-of-the-art in force balance calibration is provided with emphasis on both the load application system and the experimental design philosophy. Limitations of current systems are detailed in the areas of data quality and productivity. A unique calibration loading system integrated with formal experimental design techniques has been developed and designated as the Single-Vector Balance Calibration System (SVS). This new concept addresses the limitations of current systems. The development of a quadratic and cubic calibration design is presented. Results from experimental testing are compared and contrasted with conventional calibration systems. Analyses of data are provided that demonstrate the feasibility of this concept and provide new insights into balance calibration.

Retrofitting Steam Turbines with Expired Service Life

NASA Astrophysics Data System (ADS)

Dubrovskii, V. G.; Zubov, A. P.; Koshelev, S. A.; Babiev, A. N.; Kremer, V. L.

2018-06-01

Many pieces of equipment installed at thermal power stations (TPS) have an expired service life or are close to expiry and are obsolete. In addition, the structure of heat consumption by end users has changed. Among the ways for solving the problem of aging equipment is the retrofitting of turbines that allows for service life recovery and improvement of their performance to the modern level. The service life is recovered through replacement of high-temperature assemblies and parts of a turbine, and the performance is improved by retrofitting and major overhaul of low-temperature assemblies. Implementation of modern engineering solutions and numerical methods in designing upgraded flow paths of steam turbines considerably improves the turbine effectiveness. New flow paths include sabre-like guide vanes, integrally-machined shrouds, and effective honeycomb or axial-radial seals. The flow paths are designed using optimization and hydraulic simulation methods as well as approaches for improving the performance on the turbine blading and internal steam flow paths. Retrofitting of turbines should be performed to meet the customers' needs. The feasibility of implementation of one or another alternative must be determined on a case-by-case basis depending on the turbine conditions, the availability of reserves for generating live steam and supplying circulation water, and the demands and capacities for generation and delivery of power and heat. The main principle of retrofitting is to retain the foundation and the auxiliary and heat-exchange equipment that is fit for further operation. With the example of PT-60-130 and T-100-130, the experience is presented of a comprehensive approach to retrofitting considering the customer's current needs and the actual equipment conditions. Due to the use of modern engineering solutions and procedures, retrofitting yields updating and upgrading of the turbine at a relatively low cost.

Revision of a Fractured Uncemented Revision Stem Using a Custom Designed Punch and Retrograde Through-Knee Approach

PubMed Central

Nasr, P. J.; Keene, G. S.

2015-01-01

We report a unique case of a fractured modular cobalt chromium connection taper Revitan (Zimmer, Warsaw, IN) revision prosthesis. Macroscopic examination revealed a fracture at the diaphyseal-metaphyseal junction of this modular component. This report highlights that fractures can still occur with modern modular prostheses. We are not aware of any published failures of the Revitan revision prosthesis. We also describe a unique method of retrieval for a broken well fixed uncemented femoral stem, using a custom designed extraction instrument via a through-knee approach. PMID:25793134

Composite turbine blade design options for Claude (open) cycle OTEC power systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Penney, T R

1985-11-01

Small-scale turbine rotors made from composites offer several technical advantages for a Claude (open) cycle ocean thermal energy conversion (OTEC) power system. Westinghouse Electric Corporation has designed a composite turbine rotor/disk using state-of-the-art analysis methods for large-scale (100-MW/sub e/) open cycle OTEC applications. Near-term demonstrations using conventional low-pressure turbine blade shapes with composite material would achieve feasibility and modern credibility of the open cycle OTEC power system. Application of composite blades for low-pressure turbo-machinery potentially improves the reliability of conventional metal blades affected by stress corrosion.

One Small Step for Creo Modelers, One Giant Leap for "Grey Beards": Using MBD Methodologies to Launch Astronauts and Hardware to Near-Earth Objects such as Asteroids, the Moon and Mars

NASA Technical Reports Server (NTRS)

Jones, Corey; LaPha, Steven

2013-01-01

This presentation will focus on the modernization of design and engineering practices through the use of Model Based Definition methodology. By gathering important engineering data into one 3D digital data set, applying model annotations, and setting up model view states directly in the 3D CAD model, model-specific information can be published to Windchill and CreoView for use during the Design Review Process. This presentation will describe the methods that have been incorporated into the modeling.

Using Multimedia Technology to Teach Modern Greek Language Online in China: Development, Implementation, and Evaluation

ERIC Educational Resources Information Center

Huang, Xiaoyin; Dedegikas, Costa; Walls, Jan

2011-01-01

This article reviews the process of design, development, and implementation of the Modern Greek online courses (Chinese version) in Hellenic Studies at Simon Fraser University (SFU), in collaboration with Chinese university partners. The purpose of this study is (a) to explore the effectiveness of the course design, and (b) to reveal the…

Genetic algorithm optimization of a film cooling array on a modern turbine inlet vane

NASA Astrophysics Data System (ADS)

Johnson, Jamie J.

In response to the need for more advanced gas turbine cooling design methods that factor in the 3-D flowfield and heat transfer characteristics, this study involves the computational optimization of a pressure side film cooling array on a modern turbine inlet vane. Latin hypersquare sampling, genetic algorithm reproduction, and Reynolds-Averaged Navier Stokes (RANS) computational fluid dynamics (CFD) as an evaluation step are used to assess a total of 1,800 film cooling designs over 13 generations. The process was efficient due to the Leo CFD code's ability to estimate cooling mass flux at surface grid cells using a transpiration boundary condition, eliminating the need for remeshing between designs. The optimization resulted in a unique cooling design relative to the baseline with new injection angles, compound angles, cooling row patterns, hole sizes, a redistribution of cooling holes away from the over-cooled midspan to hot areas near the shroud, and a lower maximum surface temperature. To experimentally confirm relative design trends between the optimized and baseline designs, flat plate infrared thermography assessments were carried out at design flow conditions. Use of flat plate experiments to model vane pressure side cooling was justified through a conjugate heat transfer CFD comparison of the 3-D vane and flat plate which showed similar cooling performance trends at multiple span locations. The optimized flat plate model exhibited lower minimum surface temperatures at multiple span locations compared to the baseline. Overall, this work shows promise of optimizing film cooling to reduce design cycle time and save cooling mass flow in a gas turbine.

A Comprehensive Solution of the Problems of Ensuring the Strength of Gas Turbine Engine Compressor at the Design Stage

NASA Astrophysics Data System (ADS)

Vedeneev, V. V.; Kolotnikov, M. E.; Mossakovskii, P. A.; Kostyreva, L. A.; Abdukhakimov, F. A.; Makarov, P. V.; Pyhalov, A. A.; Dudaev, M. A.

2018-01-01

In this paper we present a complex numerical workflow for analysis of blade flutter and high-amplitude resonant oscillations, impenetrability of casing if the blade is broken off, and the rotor reaction to the blade detachment and following misbalance, with the assessment of a safe flight possibility at the auto-rotation regime. All the methods used are carefully verified by numerical convergence study and correlations with experiments. The use of the workflow developed significantly improves the efficiency of the design process of modern jet engine compressors. It ensures a significant reduction of time and cost of the compressor design with the required level of strength and durability.

Microgravity isolation system design: A modern control synthesis framework

NASA Technical Reports Server (NTRS)

Hampton, R. D.; Knospe, C. R.; Allaire, P. E.; Grodsinsky, C. M.

1994-01-01

Manned orbiters will require active vibration isolation for acceleration-sensitive microgravity science experiments. Since umbilicals are highly desirable or even indispensable for many experiments, and since their presence greatly affects the complexity of the isolation problem, they should be considered in control synthesis. In this paper a general framework is presented for applying extended H2 synthesis methods to the three-dimensional microgravity isolation problem. The methodology integrates control and state frequency weighting and input and output disturbance accommodation techniques into the basic H2 synthesis approach. The various system models needed for design and analysis are also presented. The paper concludes with a discussion of a general design philosophy for the microgravity vibration isolation problem.

Microgravity isolation system design: A modern control synthesis framework

NASA Technical Reports Server (NTRS)

Hampton, R. D.; Knospe, C. R.; Allaire, P. E.; Grodsinsky, C. M.

1994-01-01

Manned orbiters will require active vibration isolation for acceleration-sensitive microgravity science experiments. Since umbilicals are highly desirable or even indispensable for many experiments, and since their presence greatly affects the complexity of the isolation problem, they should be considered in control synthesis. A general framework is presented for applying extended H2 synthesis methods to the three-dimensional microgravity isolation problem. The methodology integrates control and state frequency weighting and input and output disturbance accommodation techniques into the basic H2 synthesis approach. The various system models needed for design and analysis are also presented. The paper concludes with a discussion of a general design philosophy for the microgravity vibration isolation problem.

Who is being served least by family planning providers? A study of modern contraceptive use in Ghana, Tanzania And Zimbabwe.

PubMed

Clements, Steve; Madise, Nyovani

2004-08-01

This study was conducted to identify the poorest and other vulnerable sub-groups being served least by family planning providers. The study was set in three countries in sub-Saharan Africa, namely, Ghana, Tanzania and Zimbabwe. This region generally has a low but increasing uptake of modern contraceptive methods. As the use of family planning providers increases, there is a need to understand who is not being served and why. Logistic regression analyses of demographic and health survey data were conducted to identify the characteristics and geographical areas of women who are not using modern contraceptive methods. The results show some similarities among the countries in those using modern methods the least. However, a number of groups were country specific. Identifying the poorest women with the lowest use of modern methods is best done by assessing their household amenities or their partner's status rather than theirs.

Attitudes of Swedes to marginal donors and xenotransplantation

PubMed Central

Lundin, S; Idvall, M

2003-01-01

The aim of our survey was to capture the attitudes of Swedes to marginal donors and xenotransplantation. Modern biotechnology makes it possible to replace non-functioning organs, cells, and genes. Nonetheless, people may have reservations and fears about such treatments. With the survey, Attitudes of the General Public to Transplants, we have sought to expose the ambivalence that arises when medical possibilities are juxtaposed with ideas of risk. The design of the questionnaire originates from the interdisciplinary cooperation between ethnologists, medical scientists, and geneticists. By combining qualitative and quantitative methods, it is possible to illustrate the complexity that characterises people's view of modern biomedicine. People's reflections are based on a personal and situation bound morality, which does not necessarily coincide with what they generally consider as ethically justifiable. PMID:12796443

A Comprehension Based Analysis of Autoflight System Interfaces

NASA Technical Reports Server (NTRS)

Palmer, Everett (Technical Monitor); Polson, Peter G.

2003-01-01

This cooperative agreement supported Dr. Peter Polson's participation in two interrelated research programs. The first was the development of the Situation-Goal-Behavior (SGB) Model that is both a formal description of an avionics system's logic and behavior and a representation of a system that can be understood by avionics designers, pilots, and training developers. The second was the development of a usability inspection method based on an approximate model, RAFIV, of pilot interactions with the Flight Management System (FMS). The main purpose of this report is to integrate the two models and provide a context in order to better characterize the accomplishments of this research program. A major focus of both the previous and this Cooperative Agreement was the development of usability evaluation methods that can be effectively utilized during all phases of the design, development, and certification process of modern avionics systems. The current efforts to validate these methods have involved showing that they generate useful analyses of known operational and training problems with the current generation of avionics systems in modern commercial airliners. This report is organized into seven sections. Following the overview, the second section describes the Goal-Situation-Behavior model and its applications. The next section summarizes the foundations of the RAFIV model and describes the model in some detail. The contents of both these sections are derived from previous reports referenced in footnotes. The fourth section integrates these two models into a complete design evaluation and training development framework. The fifth section contains conclusions and possible future directions for research. References are in Section 6. Section 7 contains the titles and abstracts of the papers paper describing in more detail the results of this research program.

High-Priority Directions of Modernization of University Education in Innovational Society

ERIC Educational Resources Information Center

Sergeev, Nikolai

2017-01-01

Purpose: The purpose of this paper is to verify the offered hypothesis and to determine high-priority directions of modernization of university education in an innovational society by the example of modern Russia. Design/methodology/approach: During the empirical study of connection between university education and innovational development of…

Modern Written Arabic, Volume II.

ERIC Educational Resources Information Center

Naja, A. Nashat; Snow, James A.

This second volume of Modern Written Arabic builds on the previous volume and is the second step designed to teach members of the Foreign Service to read the modern Arabic press. The student will gain recognitional mastery of an extensive set of vocabulary items and will be more intensively exposed to wider and more complex morphological and…

Barriers to Modern Contraceptive Use in Kinshasa, DRC.

PubMed

Muanda, Mbadu; Gahungu Ndongo, Parfait; Taub, Leah D; Bertrand, Jane T

2016-01-01

Recent research from Kinshasa, DRC, has shown that only one in five married women uses modern contraception; over one quarter have an unmet need for family planning; and almost 400 health facilities across Kinshasa report that they provide modern contraception. This study addresses the question: with reasonable physical access and relatively high unmet need, why is modern contraceptive prevalence so low? To this end, the research team conducted 6 focus groups of women (non-users of any method, users of traditional methods, and users of modern methods) and 4 of husbands (of users of traditional methods and in non-user unions) in health zones with relatively strong physical access to FP services. Five key barriers emerged from the focus group discussions: fear of side effects (especially sterility), costs of the method, sociocultural norms (especially the dominant position of the male in family decision-making), pressure from family members to avoid modern contraception, and lack of information/misinformation. These findings are very similar to those from 12 other studies of sociocultural barriers to family planning in sub-Saharan Africa. Moreover, they have strong programmatic implications for the training of FP workers to counsel future clients and for the content of behavior change communication interventions.

Tribology symposium -- 1994. PD-Volume 61

DOE Office of Scientific and Technical Information (OSTI.GOV)

Masudi, H.

This year marks the first Tribology Symposium within the Energy-Sources Technology Conference, sponsored by the ASME Petroleum Division. The program was divided into five sessions: Tribology in High Technology, a historical discussion of some watershed events in tribology; Research/Development, design, research and development on modern manufacturing; Tribology in Manufacturing, the impact of tribology on modern manufacturing; Design/Design Representation, aspects of design related to tribological systems; and Failure Analysis, an analysis of failure, failure detection, and failure monitoring as relating to manufacturing processes. Eleven papers have been processed separately for inclusion on the data base.

"Drug" Discovery with the Help of Organic Chemistry.

PubMed

Itoh, Yukihiro; Suzuki, Takayoshi

2017-01-01

The first step in "drug" discovery is to find compounds binding to a potential drug target. In modern medicinal chemistry, the screening of a chemical library, structure-based drug design, and ligand-based drug design, or a combination of these methods, are generally used for identifying the desired compounds. However, they do not necessarily lead to success and there is no infallible method for drug discovery. Therefore, it is important to explore medicinal chemistry based on not only the conventional methods but also new ideas. So far, we have found various compounds as drug candidates. In these studies, some strategies based on organic chemistry have allowed us to find drug candidates, through 1) construction of a focused library using organic reactions and 2) rational design of enzyme inhibitors based on chemical reactions catalyzed by the target enzyme. Medicinal chemistry based on organic chemical reactions could be expected to supplement the conventional methods. In this review, we present drug discovery with the help of organic chemistry showing examples of our explorative studies on histone deacetylase inhibitors and lysine-specific demethylase 1 inhibitors.

Design and optimization of mixed flow pump impeller blades by varying semi-cone angle

NASA Astrophysics Data System (ADS)

Dash, Nehal; Roy, Apurba Kumar; Kumar, Kaushik

2018-03-01

The mixed flow pump is a cross between the axial and radial flow pump. These pumps are used in a large number of applications in modern fields. For the designing of these mixed flow pump impeller blades, a lot number of design parameters are needed to be considered which makes this a tedious task for which fundamentals of turbo-machinery and fluid mechanics are always prerequisites. The semi-cone angle of mixed flow pump impeller blade has a specified range of variations generally between 45o to 60o. From the literature review done related to this topic researchers have considered only a particular semi-cone angle and all the calculations are based on this very same semi-cone angle. By varying this semi-cone angle in the specified range, it can be verified if that affects the designing of the impeller blades for a mixed flow pump. Although a lot of methods are available for designing of mixed flow pump impeller blades like inverse time marching method, the pseudo-stream function method, Fourier expansion singularity method, free vortex method, mean stream line theory method etc. still the optimized design of the mixed flow pump impeller blade has been a cumbersome work. As stated above since all the available research works suggest or propose the blade designs with constant semi-cone angle, here the authors have designed the impeller blades by varying the semi-cone angle in a particular range with regular intervals for a Mixed-Flow pump. Henceforth several relevant impeller blade designs are obtained and optimization is carried out to obtain the optimized design (blade with optimal geometry) of impeller blade.

An investigative graduate laboratory course for teaching modern DNA techniques.

PubMed

de Lencastre, Alexandre; Thomas Torello, A; Keller, Lani C

2017-07-08

This graduate-level DNA methods laboratory course is designed to model a discovery-based research project and engages students in both traditional DNA analysis methods and modern recombinant DNA cloning techniques. In the first part of the course, students clone the Drosophila ortholog of a human disease gene of their choosing using Gateway ® cloning. In the second part of the course, students examine the expression of their gene of interest in human cell lines by reverse transcription PCR and learn how to analyze data from quantitative reverse transcription PCR (qRT-PCR) experiments. The adaptability of the Gateway ® cloning system is ideally suited for students to design and create different types of expression constructs to achieve a particular experimental goal (e.g., protein purification, expression in cell culture, and/or subcellular localization), and the genes chosen can be aligned to the research interests of the instructor and/or ongoing research in a department. Student evaluations indicate that the course fostered a genuine excitement for research and in depth knowledge of both the techniques performed and the theory behind them. Our long-term goal is to incorporate this DNA methods laboratory as the foundation for an integrated laboratory sequence for the Master of Science degree program in Molecular and Cellular Biology at Quinnipiac University, where students use the reagents and concepts they developed in this course in subsequent laboratory courses, including a protein methods and cell culture laboratory. © 2017 by The International Union of Biochemistry and Molecular Biology, 45(4):351-359, 2017. © 2017 The International Union of Biochemistry and Molecular Biology.

EMU Suit Performance Simulation

NASA Technical Reports Server (NTRS)

Cowley, Matthew S.; Benson, Elizabeth; Harvill, Lauren; Rajulu, Sudhakar

2014-01-01

Introduction: Designing a planetary suit is very complex and often requires difficult trade-offs between performance, cost, mass, and system complexity. To verify that new suit designs meet requirements, full prototypes must be built and tested with human subjects. However, numerous design iterations will occur before the hardware meets those requirements. Traditional draw-prototype-test paradigms for research and development are prohibitively expensive with today's shrinking Government budgets. Personnel at NASA are developing modern simulation techniques that focus on a human-centric design paradigm. These new techniques make use of virtual prototype simulations and fully adjustable physical prototypes of suit hardware. This is extremely advantageous and enables comprehensive design down-selections to be made early in the design process. Objectives: The primary objective was to test modern simulation techniques for evaluating the human performance component of two EMU suit concepts, pivoted and planar style hard upper torso (HUT). Methods: This project simulated variations in EVA suit shoulder joint design and subject anthropometry and then measured the differences in shoulder mobility caused by the modifications. These estimations were compared to human-in-the-loop test data gathered during past suited testing using four subjects (two large males, two small females). Results: Results demonstrated that EVA suit modeling and simulation are feasible design tools for evaluating and optimizing suit design based on simulated performance. The suit simulation model was found to be advantageous in its ability to visually represent complex motions and volumetric reach zones in three dimensions, giving designers a faster and deeper comprehension of suit component performance vs. human performance. Suit models were able to discern differing movement capabilities between EMU HUT configurations, generic suit fit concerns, and specific suit fit concerns for crewmembers based on individual anthropometry

Estimating past precipitation and temperature from fossil ostracodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, A.J.; Forester, R.M.

1994-12-31

The fossil records of certain aquatic organisms provide a way of obtaining meaningful estimates of past temperature and precipitation. These estimates of past environmental conditions are derived from multivariate statistical methods that are in turn based on the modern biogeographic distributions and environmental tolerances of the biota of interest. These estimates are helpful in conducting slimate studies as part of the Yucca Mountain site characterization. Ostracodes are microscopic crustaceans that produce bivalved calcite shells which are easily fossilized in the sediments of the lakes and wetlands in which the animals lived. The modern biogeographic distribution and environmental conditions of livingmore » ostracodes are the basis for the interpretation of the past environmental conditions of the fossil ostracodes. The major assumption in this method of interpretation is that the environmental tolerances of ostracodes have not changed substantially over thousands of years. Two methods using these modern analogs to determine past environmental conditions are the modern analog method and the range method. The range method also considers the information provided by fossil ostracode assemblages that have no modern analog in today`s world.« less

RELAP-7 Level 2 Milestone Report: Demonstration of a Steady State Single Phase PWR Simulation with RELAP-7

DOE Office of Scientific and Technical Information (OSTI.GOV)

David Andrs; Ray Berry; Derek Gaston

The document contains the simulation results of a steady state model PWR problem with the RELAP-7 code. The RELAP-7 code is the next generation nuclear reactor system safety analysis code being developed at Idaho National Laboratory (INL). The code is based on INL's modern scientific software development framework - MOOSE (Multi-Physics Object-Oriented Simulation Environment). This report summarizes the initial results of simulating a model steady-state single phase PWR problem using the current version of the RELAP-7 code. The major purpose of this demonstration simulation is to show that RELAP-7 code can be rapidly developed to simulate single-phase reactor problems. RELAP-7more » is a new project started on October 1st, 2011. It will become the main reactor systems simulation toolkit for RISMC (Risk Informed Safety Margin Characterization) and the next generation tool in the RELAP reactor safety/systems analysis application series (the replacement for RELAP5). The key to the success of RELAP-7 is the simultaneous advancement of physical models, numerical methods, and software design while maintaining a solid user perspective. Physical models include both PDEs (Partial Differential Equations) and ODEs (Ordinary Differential Equations) and experimental based closure models. RELAP-7 will eventually utilize well posed governing equations for multiphase flow, which can be strictly verified. Closure models used in RELAP5 and newly developed models will be reviewed and selected to reflect the progress made during the past three decades. RELAP-7 uses modern numerical methods, which allow implicit time integration, higher order schemes in both time and space, and strongly coupled multi-physics simulations. RELAP-7 is written with object oriented programming language C++. Its development follows modern software design paradigms. The code is easy to read, develop, maintain, and couple with other codes. Most importantly, the modern software design allows the RELAP-7 code to evolve with time. RELAP-7 is a MOOSE-based application. MOOSE (Multiphysics Object-Oriented Simulation Environment) is a framework for solving computational engineering problems in a well-planned, managed, and coordinated way. By leveraging millions of lines of open source software packages, such as PETSC (a nonlinear solver developed at Argonne National Laboratory) and LibMesh (a Finite Element Analysis package developed at University of Texas), MOOSE significantly reduces the expense and time required to develop new applications. Numerical integration methods and mesh management for parallel computation are provided by MOOSE. Therefore RELAP-7 code developers only need to focus on physics and user experiences. By using the MOOSE development environment, RELAP-7 code is developed by following the same modern software design paradigms used for other MOOSE development efforts. There are currently over 20 different MOOSE based applications ranging from 3-D transient neutron transport, detailed 3-D transient fuel performance analysis, to long-term material aging. Multi-physics and multiple dimensional analyses capabilities can be obtained by coupling RELAP-7 and other MOOSE based applications and by leveraging with capabilities developed by other DOE programs. This allows restricting the focus of RELAP-7 to systems analysis-type simulations and gives priority to retain and significantly extend RELAP5's capabilities.« less

Flexible missile autopilot design studies with PC-MATLAB/386

NASA Technical Reports Server (NTRS)

Ruth, Michael J.

1989-01-01

Development of a responsive, high-bandwidth missile autopilot for airframes which have structural modes of unusually low frequency presents a challenging design task. Such systems are viable candidates for modern, state-space control design methods. The PC-MATLAB interactive software package provides an environment well-suited to the development of candidate linear control laws for flexible missile autopilots. The strengths of MATLAB include: (1) exceptionally high speed (MATLAB's version for 80386-based PC's offers benchmarks approaching minicomputer and mainframe performance); (2) ability to handle large design models of several hundred degrees of freedom, if necessary; and (3) broad extensibility through user-defined functions. To characterize MATLAB capabilities, a simplified design example is presented. This involves interactive definition of an observer-based state-space compensator for a flexible missile autopilot design task. MATLAB capabilities and limitations, in the context of this design task, are then summarized.

Study/experimental/research design: much more than statistics.

PubMed

Knight, Kenneth L

2010-01-01

The purpose of study, experimental, or research design in scientific manuscripts has changed significantly over the years. It has evolved from an explanation of the design of the experiment (ie, data gathering or acquisition) to an explanation of the statistical analysis. This practice makes "Methods" sections hard to read and understand. To clarify the difference between study design and statistical analysis, to show the advantages of a properly written study design on article comprehension, and to encourage authors to correctly describe study designs. The role of study design is explored from the introduction of the concept by Fisher through modern-day scientists and the AMA Manual of Style. At one time, when experiments were simpler, the study design and statistical design were identical or very similar. With the complex research that is common today, which often includes manipulating variables to create new variables and the multiple (and different) analyses of a single data set, data collection is very different than statistical design. Thus, both a study design and a statistical design are necessary. Scientific manuscripts will be much easier to read and comprehend. A proper experimental design serves as a road map to the study methods, helping readers to understand more clearly how the data were obtained and, therefore, assisting them in properly analyzing the results.

Getting to FP2020: Harnessing the private sector to increase modern contraceptive access and choice in Ethiopia, Nigeria, and DRC

PubMed Central

Garfinkel, Danielle; Thanel, Katherine; Esch, Keith; Workalemahu, Endale; Anyanti, Jennifer; Mpanya, Godéfroid; Binanga, Arsène; Pope, Jen; Longfield, Kim; Bertrand, Jane; Shaw, Bryan

2018-01-01

Background An estimated 214 million women have unmet need for family planning in developing regions. Improved utilization of the private sector is key to achieving universal access to a range of safe and effective modern contraceptive methods stipulated by FP2020 and SDG commitments. Until now, a lack of market data has limited understanding of the private sector’s role in increasing contraceptive coverage and choice. Methods In 2015, the FPwatch Project conducted representative outlet surveys in Ethiopia, Nigeria, and DRC using a full census approach in selected administrative areas. Every public and private sector outlet with the potential to sell or distribute modern contraceptives was approached. In outlets with modern contraceptives, product audits and provider interviews assessed contraceptive market composition, availability, and price. Findings Excluding general retailers, 96% of potential outlets in Ethiopia, 55% in Nigeria, and 41% in DRC had modern contraceptive methods available. In Ethiopia, 41% of modern contraceptive stocking outlets were in the private sector compared with approximately 80% in Nigeria and DRC where drug shops were dominant. Ninety-five percent of private sector outlets in Ethiopia had modern contraceptive methods available; 37% had three or more methods. In Nigeria and DRC, only 54% and 42% of private sector outlets stocked modern contraceptives with 5% and 4% stocking three or more methods, respectively. High prices in Nigeria and DRC create barriers to consumer access and choice. Discussion There is a missed opportunity to provide modern contraception through the private sector, particularly drug shops. Subsidies and interventions, like social marketing and social franchising, could leverage the private sector’s role in increasing access to a range of contraceptives. Achieving global FP2020 commitments depends on the expansion of national contraceptive policies that promote greater partnership and cooperation with the private sector and improvement of decisions around funding streams of countries with large populations and high unmet need like Ethiopia, Nigeria, and DRC. PMID:29444140

Comparison of variational real-space representations of the kinetic energy operator

NASA Astrophysics Data System (ADS)

Skylaris, Chris-Kriton; Diéguez, Oswaldo; Haynes, Peter D.; Payne, Mike C.

2002-08-01

We present a comparison of real-space methods based on regular grids for electronic structure calculations that are designed to have basis set variational properties, using as a reference the conventional method of finite differences (a real-space method that is not variational) and the reciprocal-space plane-wave method which is fully variational. We find that a definition of the finite-difference method [P. Maragakis, J. Soler, and E. Kaxiras, Phys. Rev. B 64, 193101 (2001)] satisfies one of the two properties of variational behavior at the cost of larger errors than the conventional finite-difference method. On the other hand, a technique which represents functions in a number of plane waves which is independent of system size closely follows the plane-wave method and therefore also the criteria for variational behavior. Its application is only limited by the requirement of having functions strictly localized in regions of real space, but this is a characteristic of an increasing number of modern real-space methods, as they are designed to have a computational cost that scales linearly with system size.

A SUMMARY COMPARISON OF DESIGN EVALUATION TECHNIQUES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spielman, Zachary; Hill, Rachael

The United States’ fleet of Nuclear Reactors is considering modernizing their control rooms and instrumentation as an effort to avoid component obsolescence, keep up with competing industries, and cater to a new work force among others. Multiple technologies have potential to improve the control room. In attempts to evaluate the available options researchers employ a variety of measures to ensure the best candidate is used in a modernizing effort. The NRC is in charge of ensuring any new design has been thoroughly vetted before approving a license. Laid out in NUREG-0711 “Human Factors Engineering Program Review Model” is the reviewmore » criteria for design validation. As there are a variety of measures currently used to evaluate candidate technologies, this paper seeks to identify weaknesses in the common measures used to design and validate technology in control room modernization efforts. Identifying where measurements are not meeting the criteria will help the control room modernization research platform identify where measurement development needs to occur. This will help ensure that current performance measurements are producing as reliable results as possible to select the right technology to integrate into nuclear operating control rooms.« less

Toward computational crime prediction. Comment on "Statistical physics of crime: A review" by M.R. D'Orsogna and M. Perc

NASA Astrophysics Data System (ADS)

Ferrara, Emilio

2015-03-01

Containing the spreading of crime in modern society in an ongoing battle: our understanding of the dynamics underlying criminal events and the motifs behind individuals therein involved is crucial to design cost-effective prevention policies and intervention strategies. During recent years we witnessed various research fields joining forces, sharing models and methods, toward modeling and quantitatively characterizing crime and criminal behavior.

A linear programming approach to characterizing norm bounded uncertainty from experimental data

NASA Technical Reports Server (NTRS)

Scheid, R. E.; Bayard, D. S.; Yam, Y.

1991-01-01

The linear programming spectral overbounding and factorization (LPSOF) algorithm, an algorithm for finding a minimum phase transfer function of specified order whose magnitude tightly overbounds a specified nonparametric function of frequency, is introduced. This method has direct application to transforming nonparametric uncertainty bounds (available from system identification experiments) into parametric representations required for modern robust control design software (i.e., a minimum-phase transfer function multiplied by a norm-bounded perturbation).

Dominance of Sterilization and Alternative Choices of Contraception in India: An Appraisal of the Socioeconomic Impact

PubMed Central

de Oliveira, Isabel Tiago; Dias, José G.; Padmadas, Sabu S.

2014-01-01

Background The recent decline in fertility in India has been unprecedented especially in southern India, where fertility is almost exclusively controlled by means of permanent contraceptive methods, mainly female sterilization, which constitutes about two-thirds of overall contraceptive use. Many Indian women undergo sterilization at relatively young ages as a consequence of early marriage and childbearing in short birth intervals. This research aims to investigate the socioeconomic factors determining the choices for alternative contraceptive choices against the dominant preference for sterilization among married women in India. Methods Data for this study are drawn from the 2005–06 National Family Health Surveys focusing on a sample of married women who reported having used a method of contraception in the five years preceding the survey. A multilevel multinomial logit regression is used to estimate the impact of socioeconomic factors on contraceptive choices, differentiating temporary modern or traditional methods versus sterilization. Findings Religious affiliation, women's education and occupation had overarching influence on method choices amongst recent users. Muslim women were at higher odds of choosing a traditional or modern temporary method than sterilization. Higher level of women's education increased the odds of modern temporary method choices but the education effect on traditional method choices was only marginally significant. Recent users belonging to wealthier households had higher odds of choosing modern methods over sterilization. Exposure to family planning messages through radio had a positive effect on modern and traditional method choices. Community variations in method choices were highly significant. Conclusion The persistent dominance of sterilization in the Indian family planning programme is largely determined by socioeconomic conditions. Reproductive health programmes should address the socioeconomic barriers and consider multiple cost-effective strategies such as mass media to promote awareness of modern temporary methods. PMID:24489759

Characterization and Developmental History of Problem Solving Methods in Medicine

PubMed Central

Harbort, Robert A.

1980-01-01

The central thesis of this paper is the importance of the framework in which information is structured. It is technically important in the design of systems; it is also important in guaranteeing that systems are usable by clinicians. Progress in medical computing depends on our ability to develop a more quantitative understanding of the role of context in our choice of problem solving techniques. This in turn will help us to design more flexible and responsive computer systems. The paper contains an overview of some models of knowledge and problem solving methods, a characterization of modern diagnostic techniques, and a discussion of skill development in medical practice. Diagnostic techniques are examined in terms of how they are taught, what problem solving methods they use, and how they fit together into an overall theory of interpretation of the medical status of a patient.

The influence of local policy on contraceptive provision and use in three locales in the Philippines.

PubMed

Lee, Romeo B; Nacionales, Lourdes P; Pedroso, Luis

2009-11-01

The Philippines has a family planning programme, but modern contraceptive prevalence has been moderate. Among low-income women, fewer are using modern methods, resulting in a fertility rate among them of 5.9. This limited use is due to lack of consistent national and local government support for modern methods because of religious opposition. Following devolution of responsibility for health services to local government in 1991, three local leaders - in Laguna Province and the cities of Manila and Puerto Princesa - passed anti-modern contraceptive policies. This paper analyses the status and impact of these policies, using information from interviews with local government officials and family planning officers, published data and studies, and accounts in national newspapers. In Laguna Province and Puerto Princesa, the policies were ineffectually implemented or short-lived. The strictly-enforced Manila law, however, has severely disrupted the city's provision of free contraception to and method use by low-income women. The great majority of Filipinos (89%) approve of modern contraceptives. There is an urgent need to improve low-income women's access to modern contraceptives through itinerant and community-based distribution, especially in poor neighbourhoods in Manila, but also throughout the country. Strategies for increasing local government support for and provision of modern methods are also needed.

Planning, creating and documenting a NASTRAN finite element model of a modern helicopter

NASA Technical Reports Server (NTRS)

Gabal, R.; Reed, D.; Ricks, R.; Kesack, W.

1985-01-01

Mathematical models based on the finite element method of structural analysis as embodied in the NASTRAN computer code are widely used by the helicopter industry to calculate static internal loads and vibration of airframe structure. The internal loads are routinely used for sizing structural members. The vibration predictions are not yet relied on during design. NASA's Langley Research Center sponsored a program to conduct an application of the finite element method with emphasis on predicting structural vibration. The Army/Boeing CH-47D helicopter was used as the modeling subject. The objective was to engender the needed trust in vibration predictions using these models and establish a body of modeling guides which would enable confident future prediction of airframe vibration as part of the regular design process.

Replace or Modernize? The Future of the District of Columbia's Endangered Old and Historic Public Schools.

ERIC Educational Resources Information Center

Twenty-First Century School Fund, Washington, DC.

This report addresses the decision-making process for replacing or modernizing the District of Columbia Public Schools (DCPS) as proposed in the DCPS facility master plan. The three-section document discusses old and historic schools and their future; the schools' historical and architectural value; cost of replacement and modernization; design;…

Effects of a Science Education Module on Attitudes towards Modern Biotechnology of Secondary School Students

NASA Astrophysics Data System (ADS)

Klop, Tanja; Severiens, Sabine E.; Knippels, Marie-Christine P. J.; van Mil, Marc H. W.; Ten Dam, Geert T. M.

2010-06-01

This article evaluated the impact of a four-lesson science module on the attitudes of secondary school students. This science module (on cancer and modern biotechnology) utilises several design principles, related to a social constructivist perspective on learning. The expectation was that the module would help students become more articulate in this particular field. In a quasi-experimental design (experimental-, control groups, and pre- and post-tests), secondary school students' attitudes (N = 365) towards modern biotechnology were measured by a questionnaire. Data were analysed using Chi-square tests. Significant differences were obtained between the control and experimental conditions. Results showed that the science module had a significant effect on attitudes, although predominantly towards a more supportive and not towards a more critical stance. It is discussed that offering a science module of this kind can indeed encourage students to become more aware of modern biotechnology, although promoting a more critical attitude towards modern biotechnology should receive more attention.

Innovative Teaching Practice: Traditional and Alternative Methods (Challenges and Implications)

ERIC Educational Resources Information Center

Nurutdinova, Aida R.; Perchatkina, Veronika G.; Zinatullina, Liliya M.; Zubkova, Guzel I.; Galeeva, Farida T.

2016-01-01

The relevance of the present issue is caused be the strong need in alternative methods of learning foreign language and the need in language training and retraining for the modern professionals. The aim of the article is to identify the basic techniques and skills in using various modern techniques in the context of modern educational tasks. The…

Development of a robust framework for controlling high performance turbofan engines

NASA Astrophysics Data System (ADS)

Miklosovic, Robert

This research involves the development of a robust framework for controlling complex and uncertain multivariable systems. Where mathematical modeling is often tedious or inaccurate, the new method uses an extended state observer (ESO) to estimate and cancel dynamic information in real time and dynamically decouple the system. As a result, controller design and tuning become transparent as the number of required model parameters is reduced. Much research has been devoted towards the application of modern multivariable control techniques on aircraft engines. However, few, if any, have been implemented on an operational aircraft, partially due to the difficulty in tuning the controller for satisfactory performance. The new technique is applied to a modern two-spool, high-pressure ratio, low-bypass turbofan with mixed-flow afterburning. A realistic Modular Aero-Propulsion System Simulation (MAPSS) package, developed by NASA, is used to demonstrate the new design process and compare its performance with that of a supplied nominal controller. This approach is expected to reduce gain scheduling over the full operating envelope of the engine and allow a controller to be tuned for engine-to-engine variations.

Principles of Experimental Design for Big Data Analysis.

PubMed

Drovandi, Christopher C; Holmes, Christopher; McGree, James M; Mengersen, Kerrie; Richardson, Sylvia; Ryan, Elizabeth G

2017-08-01

Big Datasets are endemic, but are often notoriously difficult to analyse because of their size, heterogeneity and quality. The purpose of this paper is to open a discourse on the potential for modern decision theoretic optimal experimental design methods, which by their very nature have traditionally been applied prospectively, to improve the analysis of Big Data through retrospective designed sampling in order to answer particular questions of interest. By appealing to a range of examples, it is suggested that this perspective on Big Data modelling and analysis has the potential for wide generality and advantageous inferential and computational properties. We highlight current hurdles and open research questions surrounding efficient computational optimisation in using retrospective designs, and in part this paper is a call to the optimisation and experimental design communities to work together in the field of Big Data analysis.

Principles of Experimental Design for Big Data Analysis

PubMed Central

Drovandi, Christopher C; Holmes, Christopher; McGree, James M; Mengersen, Kerrie; Richardson, Sylvia; Ryan, Elizabeth G

2016-01-01

Big Datasets are endemic, but are often notoriously difficult to analyse because of their size, heterogeneity and quality. The purpose of this paper is to open a discourse on the potential for modern decision theoretic optimal experimental design methods, which by their very nature have traditionally been applied prospectively, to improve the analysis of Big Data through retrospective designed sampling in order to answer particular questions of interest. By appealing to a range of examples, it is suggested that this perspective on Big Data modelling and analysis has the potential for wide generality and advantageous inferential and computational properties. We highlight current hurdles and open research questions surrounding efficient computational optimisation in using retrospective designs, and in part this paper is a call to the optimisation and experimental design communities to work together in the field of Big Data analysis. PMID:28883686

Unsteady Loss in the Stator Due to the Incoming Rotor Wake in a Highly-Loaded Transonic Compressor

NASA Technical Reports Server (NTRS)

Hah, Chunill

2015-01-01

The present paper reports an investigation of unsteady loss generation in the stator due to the incoming rotor wake in an advanced GE transonic compressor design with a high-fidelity numerical method. This advanced compressor with high reaction and high stage loading has been investigated both experimentally and analytically in the past. The measured efficiency in this advanced compressor is significantly lower than the design intention goal. The general understanding is that the current generation of compressor design analysis tools miss some important flow physics in this modern compressor design. To pinpoint the source of the efficiency miss, an advanced test with a detailed flow traverse was performed for the front one and a half stage at the NASA Glenn Research Center.

User-driven product data manager system design

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-03-01

With the infusion of information technologies into product development and production processes, effective management of product data is becoming essential to modern production enterprises. When an enterprise-wide Product Data Manager (PDM) is implemented, PDM designers must satisfy the requirements of individual users with different job functions and requirements, as well as the requirements of the enterprise as a whole. Concern must also be shown for the interrelationships between information, methods for retrieving archival information and integration of the PDM into the product development process. This paper describes a user-driven approach applied to PDM design for an agile manufacturing pilot projectmore » at Sandia National Laboratories that has been successful in achieving a much faster design-to-production process for a precision electro mechanical surety device.« less

Energy efficiency in urban management: Russian and world experience

NASA Astrophysics Data System (ADS)

Pryadko, Igor

2017-10-01

The article discusses the role of energetics in creating a comfortable and safe environment of modern megacities, and the problem is considered in the socio-economic aspect. The object is the energy security of the city, and the subject is the influence of urban society on the formation of energy security. In particular, the problems are raised: ecological problems of urban energy supply, the condition of surface layer of the atmosphere near electric power lines. The author assesses the actions, implemented by the urban authorities in Mytischi, in the southwestern areas of New Moscow. The author assesses these sample areas on the basis of Ch. Landry’s concept of self-training, designated for municipal authorities and urban communities, and offers several successfully implemented self-study cases and in the light of modern methods of ensuring energy security. The forecasts of creation of energy-safe space, made by modern sociologist-urbanist Leo Hollis, are taken into account. The author also considers some of the economic aspects of biosphere safety. In particular, he insists that biosphere safety, convenience, and comfort have developed into competitive advantages in the housing market.

Modern Conditions and the Impacts of the Creation of Architectural Environment

NASA Astrophysics Data System (ADS)

Abyzov, Vadym

2017-10-01

The purpose of this research is an attempt to identify and analyse the modern conditions and impacts of the creation of architectural environment and on this basis to determine the main directions and tasks of the development of architecture at the appropriate hierarchical levels. A comprehensive review and structural analysis of all impact factors and different current conditions that lead to the sustainable architecture design are conducted in the proposal. The main groups of factors and conditions such as social-economical, natural-geographic, urban, ergonomics, ecological, typological, technical, cultural, and aesthetics are determined in accordance with their contemporary specifics. This analysis provides an opportunity to define the appropriative hierarchical levels of the modern trends and prospects of creation an effective, attractive and friendly architectural environment. Some examples of author’s projects and implementations is presented in the article. Such methodological approach will help to create a holistic view of the creation architectural environment, will allow to systematize existing knowledges and concepts, practices and prospects of the means and methods of its formation and development.

C3: A Command-line Catalogue Cross-matching tool for modern astrophysical survey data

NASA Astrophysics Data System (ADS)

Riccio, Giuseppe; Brescia, Massimo; Cavuoti, Stefano; Mercurio, Amata; di Giorgio, Anna Maria; Molinari, Sergio

2017-06-01

In the current data-driven science era, it is needed that data analysis techniques has to quickly evolve to face with data whose dimensions has increased up to the Petabyte scale. In particular, being modern astrophysics based on multi-wavelength data organized into large catalogues, it is crucial that the astronomical catalog cross-matching methods, strongly dependant from the catalogues size, must ensure efficiency, reliability and scalability. Furthermore, multi-band data are archived and reduced in different ways, so that the resulting catalogues may differ each other in formats, resolution, data structure, etc, thus requiring the highest generality of cross-matching features. We present C 3 (Command-line Catalogue Cross-match), a multi-platform application designed to efficiently cross-match massive catalogues from modern surveys. Conceived as a stand-alone command-line process or a module within generic data reduction/analysis pipeline, it provides the maximum flexibility, in terms of portability, configuration, coordinates and cross-matching types, ensuring high performance capabilities by using a multi-core parallel processing paradigm and a sky partitioning algorithm.

Incorporating modern neuroscience findings to improve brain-computer interfaces: tracking auditory attention.

PubMed

Wronkiewicz, Mark; Larson, Eric; Lee, Adrian Kc

2016-10-01

Brain-computer interface (BCI) technology allows users to generate actions based solely on their brain signals. However, current non-invasive BCIs generally classify brain activity recorded from surface electroencephalography (EEG) electrodes, which can hinder the application of findings from modern neuroscience research. In this study, we use source imaging-a neuroimaging technique that projects EEG signals onto the surface of the brain-in a BCI classification framework. This allowed us to incorporate prior research from functional neuroimaging to target activity from a cortical region involved in auditory attention. Classifiers trained to detect attention switches performed better with source imaging projections than with EEG sensor signals. Within source imaging, including subject-specific anatomical MRI information (instead of using a generic head model) further improved classification performance. This source-based strategy also reduced accuracy variability across three dimensionality reduction techniques-a major design choice in most BCIs. Our work shows that source imaging provides clear quantitative and qualitative advantages to BCIs and highlights the value of incorporating modern neuroscience knowledge and methods into BCI systems.

Dominance of sterilization and alternative choices of contraception in India: an appraisal of the socioeconomic impact.

PubMed

de Oliveira, Isabel Tiago; Dias, José G; Padmadas, Sabu S

2014-01-01

The recent decline in fertility in India has been unprecedented especially in southern India, where fertility is almost exclusively controlled by means of permanent contraceptive methods, mainly female sterilization, which constitutes about two-thirds of overall contraceptive use. Many Indian women undergo sterilization at relatively young ages as a consequence of early marriage and childbearing in short birth intervals. This research aims to investigate the socioeconomic factors determining the choices for alternative contraceptive choices against the dominant preference for sterilization among married women in India. Data for this study are drawn from the 2005-06 National Family Health Surveys focusing on a sample of married women who reported having used a method of contraception in the five years preceding the survey. A multilevel multinomial logit regression is used to estimate the impact of socioeconomic factors on contraceptive choices, differentiating temporary modern or traditional methods versus sterilization. Religious affiliation, women's education and occupation had overarching influence on method choices amongst recent users. Muslim women were at higher odds of choosing a traditional or modern temporary method than sterilization. Higher level of women's education increased the odds of modern temporary method choices but the education effect on traditional method choices was only marginally significant. Recent users belonging to wealthier households had higher odds of choosing modern methods over sterilization. Exposure to family planning messages through radio had a positive effect on modern and traditional method choices. Community variations in method choices were highly significant. The persistent dominance of sterilization in the Indian family planning programme is largely determined by socioeconomic conditions. Reproductive health programmes should address the socioeconomic barriers and consider multiple cost-effective strategies such as mass media to promote awareness of modern temporary methods.

Advanced boundary layer transition measurement methods for flight applications

NASA Technical Reports Server (NTRS)

Holmes, B. J.; Croom, C. C.; Gail, P. D.; Manuel, G. S.; Carraway, D. L.

1986-01-01

In modern laminar flow flight research, it is important to understand the specific cause(s) of laminar to turbulent boundary-layer transition. Such information is crucial to the exploration of the limits of practical application of laminar flow for drag reduction on aircraft. The transition modes of interest in current flight investigations include the viscous Tollmien-Schlichting instability, the inflectional instability at laminar separation, and the crossflow inflectional instability, as well as others. This paper presents the results to date of research on advanced devices and methods used for the study of laminar boundary-layer transition phenomena in the flight environment. Recent advancements in the development of arrayed hot-film devices and of a new flow visualization method are discussed. Arrayed hot-film devices have been designed to detect the presence of laminar separation, and of crossflow vorticity. The advanced flow visualization method utilizes color changes in liquid-crystal coatings to detect boundary-layer transition at high altitude flight conditions. Flight and wind tunnel data are presented to illustrate the design and operation of these advanced methods. These new research tools provide information on disturbance growth and transition mode which is essential to furthering our understanding of practical design limits for applications of laminar flow technology.

Urban Planning by Le Corbusier According to Praxeological Knowledge

NASA Astrophysics Data System (ADS)

Dzwierzynska, Jolanta; Prokopska, Aleksandra

2017-12-01

The city is formed as a mosaic of various elements which affect its attractiveness. These elements range from location attributes, through economic opportunities, to social aspects. Therefore, urbanity and urban planning should be considered in a multi-dimensional context. In the paper we address the problem of urban planning by Le Corbusier according to praxeological and system knowledge. From praxeological point of view an active human being takes his/her choice between various possibilities by preferring one of these possibilities to the others, and by manifesting it by her actions. The same applies to the design process. Due to this fact, the scientific design process can be treated as a systematic rational reconstruction of the designer’s behaviour. Such a reconstruction requires previous reflection on designer’s work, as well as some consideration and design experience, thus know-how knowledge based on methodological knowledge. In the paper several city visions of Le Corbusier, as well as the characteristics and organisation of his design process are analysed. Le Corbusier’s innovative design ideas resulted from industrialisation changes and motorisation accelerating progress, which gave foundation to a new urban array. This array based on strict geometric forms, regularity and repetition determining standard. Thanks to his theories, Le Corbusier established principles of modern city construction and planning. Although some doubts were expressed as to the scale of centralisation of the cities designed by him and his class-based conception, he was awarded that overall welfare of the individual living in a city was the quality of built environment. Therefore, his designed creations were not only functional but they also produced emotions. The analysis of his prolific design activities allows us to state that the organisation of his architectural and urban planning process was very efficient and complex. The city concepts proposed by him were the subject of analysis by generations of designers. Also now, they can still be the basis for modelling virtual and navigable cities by modern planners. Le Corbusier’s comprehensive approach to modern city planning showed that research activities, that is theoretical thinking, and production activities, that is practice, are linked methodically. Therefore, urban planning should be understood not only as a projection of the possibilities of architecture, but as a multidisciplinary process. Due to this fact, an urban plan, as a result of that process, should be a synthesis of various social, industrial and economic aspects.

Statistical controversies in clinical research: early-phase adaptive design for combination immunotherapies.

PubMed

Wages, N A; Slingluff, C L; Petroni, G R

2017-04-01

In recent years, investigators have asserted that the 3 + 3 design lacks flexibility, making its use in modern early-phase trial settings, such as combinations and/or biological agents, inefficient. More innovative approaches are required to address contemporary research questions, such as those posed in trials involving immunotherapies. We describe the implementation of an adaptive design for identifying an optimal treatment regimen, defined by low toxicity and high immune response, in an early-phase trial of a melanoma helper peptide vaccine plus novel adjuvant combinations. Operating characteristics demonstrate the ability of the method to effectively recommend optimal regimens in a high percentage of trials with reasonable sample sizes. The proposed design is a practical, early-phase, adaptive method for use with combined immunotherapy regimens. This design can be applied more broadly to early-phase combination studies, as it was used in an ongoing study of two small molecule inhibitors in relapsed/refractory mantle cell lymphoma. © The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

A Matrix-Free Algorithm for Multidisciplinary Design Optimization

NASA Astrophysics Data System (ADS)

Lambe, Andrew Borean

Multidisciplinary design optimization (MDO) is an approach to engineering design that exploits the coupling between components or knowledge disciplines in a complex system to improve the final product. In aircraft design, MDO methods can be used to simultaneously design the outer shape of the aircraft and the internal structure, taking into account the complex interaction between the aerodynamic forces and the structural flexibility. Efficient strategies are needed to solve such design optimization problems and guarantee convergence to an optimal design. This work begins with a comprehensive review of MDO problem formulations and solution algorithms. First, a fundamental MDO problem formulation is defined from which other formulations may be obtained through simple transformations. Using these fundamental problem formulations, decomposition methods from the literature are reviewed and classified. All MDO methods are presented in a unified mathematical notation to facilitate greater understanding. In addition, a novel set of diagrams, called extended design structure matrices, are used to simultaneously visualize both data communication and process flow between the many software components of each method. For aerostructural design optimization, modern decomposition-based MDO methods cannot efficiently handle the tight coupling between the aerodynamic and structural states. This fact motivates the exploration of methods that can reduce the computational cost. A particular structure in the direct and adjoint methods for gradient computation motivates the idea of a matrix-free optimization method. A simple matrix-free optimizer is developed based on the augmented Lagrangian algorithm. This new matrix-free optimizer is tested on two structural optimization problems and one aerostructural optimization problem. The results indicate that the matrix-free optimizer is able to efficiently solve structural and multidisciplinary design problems with thousands of variables and constraints. On the aerostructural test problem formulated with thousands of constraints, the matrix-free optimizer is estimated to reduce the total computational time by up to 90% compared to conventional optimizers.

A Matrix-Free Algorithm for Multidisciplinary Design Optimization

NASA Astrophysics Data System (ADS)

Lambe, Andrew Borean

Multidisciplinary design optimization (MDO) is an approach to engineering design that exploits the coupling between components or knowledge disciplines in a complex system to improve the final product. In aircraft design, MDO methods can be used to simultaneously design the outer shape of the aircraft and the internal structure, taking into account the complex interaction between the aerodynamic forces and the structural flexibility. Efficient strategies are needed to solve such design optimization problems and guarantee convergence to an optimal design. This work begins with a comprehensive review of MDO problem formulations and solution algorithms. First, a fundamental MDO problem formulation is defined from which other formulations may be obtained through simple transformations. Using these fundamental problem formulations, decomposition methods from the literature are reviewed and classified. All MDO methods are presented in a unified mathematical notation to facilitate greater understanding. In addition, a novel set of diagrams, called extended design structure matrices, are used to simultaneously visualize both data communication and process flow between the many software components of each method. For aerostructural design optimization, modern decomposition-based MDO methods cannot efficiently handle the tight coupling between the aerodynamic and structural states. This fact motivates the exploration of methods that can reduce the computational cost. A particular structure in the direct and adjoint methods for gradient computation. motivates the idea of a matrix-free optimization method. A simple matrix-free optimizer is developed based on the augmented Lagrangian algorithm. This new matrix-free optimizer is tested on two structural optimization problems and one aerostructural optimization problem. The results indicate that the matrix-free optimizer is able to efficiently solve structural and multidisciplinary design problems with thousands of variables and constraints. On the aerostructural test problem formulated with thousands of constraints, the matrix-free optimizer is estimated to reduce the total computational time by up to 90% compared to conventional optimizers.

Computational Chemistry Using Modern Electronic Structure Methods

ERIC Educational Resources Information Center

Bell, Stephen; Dines, Trevor J.; Chowdhry, Babur Z.; Withnall, Robert

2007-01-01

Various modern electronic structure methods are now days used to teach computational chemistry to undergraduate students. Such quantum calculations can now be easily used even for large size molecules.

Mendel in the Modern Classroom

NASA Astrophysics Data System (ADS)

Smith, Mike U.; Gericke, Niklas M.

2015-01-01

Mendel is an icon in the history of genetics and part of our common culture and modern biology instruction. The aim of this paper is to summarize the place of Mendel in the modern biology classroom. In the present article we will identify key issues that make Mendel relevant in the classroom today. First, we recount some of the historical controversies that have relevance to modern curricular design, such as Fisher's (Ann Sci 1:115-137, 1936/2008) claim that Mendel's data were too good to be true. We also address questions about Mendel's status as the father of genetics as well as questions about the sequencing of Mendel's work in genetics instruction in relation to modern molecular genetics and evolution. Next, we present a systematic set of examples of research based approaches to the use of Mendel in the modern classroom along with criticisms of these designs and questions about the historical accuracy of the story of Mendel as presented in the typical classroom. Finally, we identify gaps in our understanding in need of further study and present a selected set of resources that, along with the references cited, should be valuable to science educators interested in further study of the story of Mendel.

Symposium on Aviation Psychology, 1st, Ohio State University, Columbus, OH, April 21, 22, 1981, Proceedings

NASA Technical Reports Server (NTRS)

1981-01-01

The impact of modern technology on the role, responsibility, authority, and performance of human operators in modern aircraft and ATC systems was examined in terms of principles defined by Paul Fitts. Research into human factors in aircraft operations and the use of human factors engineering for aircraft safety improvements were discussed, and features of the man-machine interface in computerized cockpit warning systems are examined. The design and operational features of computerized avionics displays and HUDs are described, along with results of investigations into pilot decision-making behavior, aircrew procedural compliance, and aircrew judgment training programs. Experiments in vision and visual perception are detailed, as are behavioral studies of crew workload, coordination, and complement. The effectiveness of pilot selection, screening, and training techniques are assessed, as are methods for evaluating pilot performance.

[Implementation of modern trends in the methods of the ventilation support in the new apparatus for artificial lung ventilation Avenir-221 P].

PubMed

Gal'perin, Iu Sh; Alkhimova, L R; Dmitriev, N D; Kozlova, I A; Nemirovskiĭ, S B; Makarov, M V; Safronov, A Iu

2005-01-01

In the new ventilator Avenir-221 P modern lines of development of ventilation support in intensive therapy of adults and children are implemented. The capacities of the ventilator are successfully combined with its technical decisions which include microprocessor parametrical controlling, programming-controlled electric drive, an information saturation, intuitively clear control system, protection against interruption of power supply sources and oxygen feeding falls. A set of functional characteristics (modes VCV, PCV, Ass/Contr, PSV, SIMV, PEEP, Sigh, etc.) in combination with an original design make the device the most accessible and promising for application in intensive care and resuscitation units of a wide network of Russian hospitals and clinics. The ventilator Avenir-221 P has passed all required tests and is presently commercially available.

Re-analysis of Alaskan benchmark glacier mass-balance data using the index method

USGS Publications Warehouse

Van Beusekom, Ashely E.; O'Nell, Shad R.; March, Rod S.; Sass, Louis C.; Cox, Leif H.

2010-01-01

At Gulkana and Wolverine Glaciers, designated the Alaskan benchmark glaciers, we re-analyzed and re-computed the mass balance time series from 1966 to 2009 to accomplish our goal of making more robust time series. Each glacier's data record was analyzed with the same methods. For surface processes, we estimated missing information with an improved degree-day model. Degree-day models predict ablation from the sum of daily mean temperatures and an empirical degree-day factor. We modernized the traditional degree-day model and derived new degree-day factors in an effort to match the balance time series more closely. We estimated missing yearly-site data with a new balance gradient method. These efforts showed that an additional step needed to be taken at Wolverine Glacier to adjust for non-representative index sites. As with the previously calculated mass balances, the re-analyzed balances showed a continuing trend of mass loss. We noted that the time series, and thus our estimate of the cumulative mass loss over the period of record, was very sensitive to the data input, and suggest the need to add data-collection sites and modernize our weather stations.

Advancing Fenton and photo-Fenton water treatment through the catalyst design.

PubMed

Vorontsov, Alexander V

2018-04-20

The review is devoted to modern Fenton, photo-Fenton, as well as Fenton-like and photo-Fenton-like reactions with participation of iron species in liquid phase and as heterogeneous catalysts. Mechanisms of these reactions were considered that include hydroxyl radical and oxoferryl species as the reactive intermediates. The barriers in the way of application of these reactions to wastewater treatment were discussed. The following fundamental problems need further research efforts: inclusion of more mechanism steps and quantum calculations of all rate constants lacking in the literature, checking the outer sphere electron transfer contribution, determination of the causes for the key changes in the homogeneous Fenton reaction mechanism with a change in the reagents concentration. The key advances for Fenton reactions implementation for the water treatment are related to tremendous hydrodynamical effects on the catalytic activity, design of ligands for high rate and completeness of mineralization in short time, and design of highly active heterogeneous catalysts. While both homogeneous and heterogeneous Fenton and photo-Fenton systems are open for further improvements, heterogeneous photo-Fenton systems are most promising for practical applications because of the inherent higher catalyst stability. Modern methods of quantum chemistry are expected to play a continuously increasing role in development of such catalysts. Copyright © 2018 Elsevier B.V. All rights reserved.

Mechanical design and analysis of a low beta squeezed half-wave resonator

NASA Astrophysics Data System (ADS)

He, Shou-Bo; Zhang, Cong; Yue, Wei-Ming; Wang, Ruo-Xu; Xu, Meng-Xin; Wang, Zhi-Jun; Huang, Shi-Chun; Huang, Yu-Lu; Jiang, Tian-Cai; Wang, Feng-Feng; Zhang, Sheng-Xue; He, Yuan; Zhang, Sheng-Hu; Zhao, Hong-Wei

2014-08-01

A superconducting squeezed type half-wave resonator (HWR) of β=0.09 has been developed at the Institute of Modern Physics, Lanzhou. In this paper, a basic design is presented for the stiffening structure for the detuning effect caused by helium pressure and Lorentz force. The mechanical modal analysis has been investigated the with finite element method (FEM). Based on these considerations, a new stiffening structure is proposed for the HWR cavity. The computation results concerning the frequency shift show that the low beta HWR cavity with new stiffening structure has low frequency sensitivity coefficient df/dp and Lorentz force detuning coefficient KL, and stable mechanical properties.

State of the art of sonic boom modeling

NASA Astrophysics Data System (ADS)

Plotkin, Kenneth J.

2002-01-01

Based on fundamental theory developed through the 1950s and 1960s, sonic boom modeling has evolved into practical tools. Over the past decade, there have been requirements for design tools for an advanced supersonic transport, and for tools for environmental assessment of various military and aerospace activities. This has resulted in a number of advances in the understanding of the physics of sonic booms, including shock wave rise times, propagation through turbulence, and blending sonic boom theory with modern computational fluid dynamics (CFD) aerodynamic design methods. This article reviews the early fundamental theory, recent advances in theory, and the application of these advances to practical models.

State of the art of sonic boom modeling.

PubMed

Plotkin, Kenneth J

2002-01-01

Based on fundamental theory developed through the 1950s and 1960s, sonic boom modeling has evolved into practical tools. Over the past decade, there have been requirements for design tools for an advanced supersonic transport, and for tools for environmental assessment of various military and aerospace activities. This has resulted in a number of advances in the understanding of the physics of sonic booms, including shock wave rise times, propagation through turbulence, and blending sonic boom theory with modern computational fluid dynamics (CFD) aerodynamic design methods. This article reviews the early fundamental theory, recent advances in theory, and the application of these advances to practical models.

APPLICATION OF SPATIAL INFORMATION TECHNOLOGY TO PETROLEUM RESOURCE ASSESSMENT ANALYSIS.

USGS Publications Warehouse

Miller, Betty M.; Domaratz, Michael A.

1984-01-01

Petroleum resource assessment procedures require the analysis of a large volume of spatial data. The US Geological Survey (USGS) has developed and applied spatial information handling procedures and digital cartographic techniques to a recent study involving the assessment of oil and gas resource potential for 74 million acres of designated and proposed wilderness lands in the western United States. The part of the study which dealt with the application of spatial information technology to petroleum resource assessment procedures is reviewed. A method was designed to expedite the gathering, integrating, managing, manipulating and plotting of spatial data from multiple data sources that are essential in modern resource assessment procedures.

Optical isolation based on space-time engineered asymmetric photonic band gaps

NASA Astrophysics Data System (ADS)

Chamanara, Nima; Taravati, Sajjad; Deck-Léger, Zoé-Lise; Caloz, Christophe

2017-10-01

Nonreciprocal electromagnetic devices play a crucial role in modern microwave and optical technologies. Conventional methods for realizing such systems are incompatible with integrated circuits. With recent advances in integrated photonics, the need for efficient on-chip magnetless nonreciprocal devices has become more pressing than ever. This paper leverages space-time engineered asymmetric photonic band gaps to generate optical isolation. It shows that a properly designed space-time modulated slab is highly reflective/transparent for opposite directions of propagation. The corresponding design is magnetless, accommodates low modulation frequencies, and can achieve very high isolation levels. An experimental proof of concept at microwave frequencies is provided.

Nanostructured thick 3D nanofibrous scaffold can induce bone.

PubMed

Eap, Sandy; Morand, David; Clauss, François; Huck, Olivier; Stoltz, Jean-François; Lutz, Jean-Christophe; Gottenberg, Jacques-Eric; Benkirane-Jessel, Nadia; Keller, Laetitia; Fioretti, Florence

2015-01-01

Designing unique nanostructured biomimetic materials is a new challenge in modern regenerative medicine. In order to develop functional substitutes for damaged organs or tissues, several methods have been used to create implants able to regenerate robust and durable bone. Electrospinning produces nonwoven scaffolds based on polymer nanofibers mimicking the fibrillar organization of bone extracellular matrix. Here, we describe a biomimetic 3D thick nanofibrous scaffold obtained by electrospinning of the biodegradable, bioresorbable and FDA-approved polymer, poly(ε-caprolactone). Such scaffold presents a thickness reaching one centimeter. We report here the demonstration that the designed nanostructured implant is able to induce in vivo bone regeneration.

Getting to FP2020: Harnessing the private sector to increase modern contraceptive access and choice in Ethiopia, Nigeria, and DRC.

PubMed

Riley, Christina; Garfinkel, Danielle; Thanel, Katherine; Esch, Keith; Workalemahu, Endale; Anyanti, Jennifer; Mpanya, Godéfroid; Binanga, Arsène; Pope, Jen; Longfield, Kim; Bertrand, Jane; Shaw, Bryan

2018-01-01

An estimated 214 million women have unmet need for family planning in developing regions. Improved utilization of the private sector is key to achieving universal access to a range of safe and effective modern contraceptive methods stipulated by FP2020 and SDG commitments. Until now, a lack of market data has limited understanding of the private sector's role in increasing contraceptive coverage and choice. In 2015, the FPwatch Project conducted representative outlet surveys in Ethiopia, Nigeria, and DRC using a full census approach in selected administrative areas. Every public and private sector outlet with the potential to sell or distribute modern contraceptives was approached. In outlets with modern contraceptives, product audits and provider interviews assessed contraceptive market composition, availability, and price. Excluding general retailers, 96% of potential outlets in Ethiopia, 55% in Nigeria, and 41% in DRC had modern contraceptive methods available. In Ethiopia, 41% of modern contraceptive stocking outlets were in the private sector compared with approximately 80% in Nigeria and DRC where drug shops were dominant. Ninety-five percent of private sector outlets in Ethiopia had modern contraceptive methods available; 37% had three or more methods. In Nigeria and DRC, only 54% and 42% of private sector outlets stocked modern contraceptives with 5% and 4% stocking three or more methods, respectively. High prices in Nigeria and DRC create barriers to consumer access and choice. There is a missed opportunity to provide modern contraception through the private sector, particularly drug shops. Subsidies and interventions, like social marketing and social franchising, could leverage the private sector's role in increasing access to a range of contraceptives. Achieving global FP2020 commitments depends on the expansion of national contraceptive policies that promote greater partnership and cooperation with the private sector and improvement of decisions around funding streams of countries with large populations and high unmet need like Ethiopia, Nigeria, and DRC.

CAN-DO, CFD-based Aerodynamic Nozzle Design and Optimization program for supersonic/hypersonic wind tunnels

NASA Technical Reports Server (NTRS)

Korte, John J.; Kumar, Ajay; Singh, D. J.; White, J. A.

1992-01-01

A design program is developed which incorporates a modern approach to the design of supersonic/hypersonic wind-tunnel nozzles. The approach is obtained by the coupling of computational fluid dynamics (CFD) with design optimization. The program can be used to design a 2D or axisymmetric, supersonic or hypersonic, wind-tunnel nozzles that can be modeled with a calorically perfect gas. The nozzle design is obtained by solving a nonlinear least-squares optimization problem (LSOP). The LSOP is solved using an iterative procedure which requires intermediate flowfield solutions. The nozzle flowfield is simulated by solving the Navier-Stokes equations for the subsonic and transonic flow regions and the parabolized Navier-Stokes equations for the supersonic flow regions. The advantages of this method are that the design is based on the solution of the viscous equations eliminating the need to make separate corrections to a design contour, and the flexibility of applying the procedure to different types of nozzle design problems.

Recognizing ancient papyri by a combination of spectroscopic, diffractional and chromatographic analytical tools

PubMed Central

Łojewska, J.; Rabin, I.; Pawcenis, D.; Bagniuk, J.; Aksamit-Koperska, M. A.; Sitarz, M.; Missori, M.; Krutzsch, M.

2017-01-01

Ancient papyri are a written heritage of culture that flourished more than 3000 years ago in Egypt. One of the most significant collections in the world is housed in the Egyptian Museum and Papyrus Collection in Berlin, from where the samples for our investigation come. The papyrologists, curators and conservators of such collections search intensely for the analytical detail that would allow ancient papyri to be distinguished from modern fabrications, in order to detect possible forgeries, assess papyrus deterioration state, and improve the design of storage conditions and conservation methods. This has become the aim of our investigation. The samples were studied by a number of methods, including spectroscopic (FTIR, fluorescent-FS, Raman) diffractional (XRD) and chromatographic (size exclusion chromatography-SEC), selected in order to determine degradation parameters: overall oxidation of lignocellulosic material, degree of polymerization and crystallinity of cellulose. The results were correlated with those obtained from carefully selected model samples including modern papyri and paper of different composition aged at elevated temperature in humid air. The methods were classified in the order SEC > FS > FTIR > XRD, based on their effectiveness in discriminating the state of papyri degradation. However, the most trustworthy evaluation of the age of papyri samples should rely on several methods. PMID:28382971

Recognizing ancient papyri by a combination of spectroscopic, diffractional and chromatographic analytical tools.

PubMed

Łojewska, J; Rabin, I; Pawcenis, D; Bagniuk, J; Aksamit-Koperska, M A; Sitarz, M; Missori, M; Krutzsch, M

2017-04-06

Ancient papyri are a written heritage of culture that flourished more than 3000 years ago in Egypt. One of the most significant collections in the world is housed in the Egyptian Museum and Papyrus Collection in Berlin, from where the samples for our investigation come. The papyrologists, curators and conservators of such collections search intensely for the analytical detail that would allow ancient papyri to be distinguished from modern fabrications, in order to detect possible forgeries, assess papyrus deterioration state, and improve the design of storage conditions and conservation methods. This has become the aim of our investigation. The samples were studied by a number of methods, including spectroscopic (FTIR, fluorescent-FS, Raman) diffractional (XRD) and chromatographic (size exclusion chromatography-SEC), selected in order to determine degradation parameters: overall oxidation of lignocellulosic material, degree of polymerization and crystallinity of cellulose. The results were correlated with those obtained from carefully selected model samples including modern papyri and paper of different composition aged at elevated temperature in humid air. The methods were classified in the order SEC > FS > FTIR > XRD, based on their effectiveness in discriminating the state of papyri degradation. However, the most trustworthy evaluation of the age of papyri samples should rely on several methods.

A Century of Enzyme Kinetic Analysis, 1913 to 2013

PubMed Central

Johnson, Kenneth A.

2013-01-01

This review traces the history and logical progression of methods for quantitative analysis of enzyme kinetics from the 1913 Michaelis and Menten paper to the application of modern computational methods today. Following a brief review of methods for fitting steady state kinetic data, modern methods are highlighted for fitting full progress curve kinetics based upon numerical integration of rate equations, including a re-analysis of the original Michaelis-Menten full time course kinetic data. Finally, several illustrations of modern transient state kinetic methods of analysis are shown which enable the elucidation of reactions occurring at the active sites of enzymes in order to relate structure and function. PMID:23850893

Feasibility of Tactical Air Delivery Resupply Using Gliders

DTIC Science & Technology

2016-12-01

using modern design and manufacturing techniques including AutoCAD, 3D printing , laser cutting and CorelDraw, and conducting field testing and...Sparrow,” using modern design and manufacturing techniques including AutoCAD, 3D printing , laser cutting and CorelDraw, and conducting field testing and...the desired point(s) of impact due to the atmospheric three-dimensional ( 3D ) wind and density field encountered by the descending load under canopy

Design and simulation of permanent magnet synchronous motor control system

NASA Astrophysics Data System (ADS)

Li, Li; Liu, Yongqiu

2018-06-01

In recent years, with the development of power electronics, microelectronics, new motor control theory and rare earth permanent magnet materials, permanent magnet synchronous motors have been rapidly applied. Permanent magnet synchronous motors have the advantages of small size, low loss and high efficiency. Today, energy conservation and environmental protection are increasingly valued. It is very necessary to study them. Permanent magnet synchronous motor control system has a wide range of application prospects in the fields of electric vehicles, ships and other transportation. Using the simulation function of MATLAB/SIMULINK, a modular design structure was used to simulate the whole system model of speed loop adjustment, current PI modulation, SVPWM (Space Vector Pulse Width Module) wave generation and double closed loop. The results show that this control method has good robustness, and this method can improve the design efficiency and shorten the system design time. In this article, the analysis of the control principle of modern permanent magnet synchronous motor and the various processes of MATLAB simulation application will be analyzed in detail. The basic theory, basic method and application technology of the permanent magnet synchronous motor control system are systematically introduced.

A study protocol: using demand-side financing to meet the birth spacing needs of the underserved in Punjab Province in Pakistan

PubMed Central

2014-01-01

Background High fertility rates, unwanted pregnancies, low modern contraceptive prevalence and a huge unmet need for contraception adversely affect women’s health in Pakistan and this problem is compounded by limited access to reliable information and quality services regarding birth spacing especially in rural and underserved areas. This paper presents a study protocol that describes an evaluation of a demand-side financing (DSF) voucher approach which aims to increase the uptake of modern contraception among women of the lowest two wealth quintiles in Punjab Province, Pakistan. Methods/Design This study will use quasi-experimental design with control arm and be implemented in: six government clinics from the Population Welfare Department; 24 social franchise facilities branded as ‘Suraj’ (Sun), led by Marie Stopes Society (a local non-governmental organization); and 12 private sector clinics in Chakwal, Mianwali and Bhakkar districts. The study respondents will be interviewed at baseline and endline subject to voluntary acceptance and medical eligibility. In addition, health service data will record each client visit during the study period. Discussion The study will examine the impact of vouchers in terms of increasing the uptake of modern contraception by engaging private and public sector service providers (mid-level and medical doctors). If found effective, this approach can be a viable solution to satisfying the current demand and meeting the unmet need for contraception, particularly among the poorest socio-economic group. PMID:24885657

Development (design and systematization) of HMS Group pump ranges

NASA Astrophysics Data System (ADS)

Tverdokhleb, I.; Yamburenko, V.

2017-08-01

The article reveals the need for pump range charts development for different applications and describes main principles used by HMS Group. Some modern approaches to pump selection are reviewed and highlighted the need for pump compliance with international standards and modern customer requirements. Even though pump design types are similar for different applications they need adjustment to specific requirements, which gets manufacturers develop their particular design for each pump range. Having wide pump ranges for different applications enables to create pump selection software, facilitating manufacturers to prepare high quality quotations in shortest time.

Improvements in the efficiency of turboexpanders in cryogenic applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agahi, R.R.; Lin, M.C.; Ershaghi, B.

1996-12-31

Process designers have utilized turboexpanders in cryogenic processes because of their higher thermal efficiencies when compared with conventional refrigeration cycles. Process design and equipment performance have improved substantially through the utilization of modern technologies. Turboexpander manufacturers have also adopted Computational Fluid Dynamic Software, Computer Numerical Control Technology and Holography Techniques to further improve an already impressive turboexpander efficiency performance. In this paper, the authors explain the design process of the turboexpander utilizing modern technology. Two cases of turboexpanders processing helium (4.35{degrees}K) and hydrogen (56{degrees}K) will be presented.

Designing families and solid citizens: the dialectic of modernity and the Matrimonial Causes Bill, 1959.

PubMed

Walter, J

2001-01-01

Policy-makers in the 1940s and 50s were intent on designing families which would produce solid citizens to engage in nation building. Historians offamilism treat it as an expression of modernism: a unifying, oppressive discourse now to be countered by the destabilising project of postmodernism. But this is not the whole story, for it omits the dialectical essence of 'the modern', which promises both 'progress' through technical rationality and individual achievement/self fulfilment. The other side of the dialectic has been avoided by dismissing individualism as a process of interpellation closely tied to the interests of technocratic elites. Out of the discontinuities within modernism there emerged opportunities for agency, the chance for people to make their own lives. The public controversy over the Matrimonial Causes Bill, 1959-at the height of what we are encouraged to think of as the familist decade-is explored as one instance.

Final report bridge design system analysis and modernization.

DOT National Transportation Integrated Search

2016-09-27

The Bridge Design System (BDS) is an in-house software program developed by the Michigan Department of Transportations : (MDOT) Bridge Design Unit. The BDS designs bridges according to the required specifications, and outputs corresponding design ...

Control methods for aiding a pilot during STOL engine failure transients

NASA Technical Reports Server (NTRS)

Nelson, E. R.; Debra, D. B.

1976-01-01

Candidate autopilot control laws that control the engine failure transient sink rates by demonstrating the engineering application of modern state variable control theory were defined. The results of approximate modal analysis were compared to those derived from full state analyses provided from computer design solutions. The aircraft was described, and a state variable model of its longitudinal dynamic motion due to engine and control variations was defined. The classical fast and slow modes were assumed to be sufficiently different to define reduced order approximations of the aircraft motion amendable to hand analysis control definition methods. The original state equations of motion were also applied to a large scale state variable control design program, in particular OPTSYS. The resulting control laws were compared with respect to their relative responses, ease of application, and meeting the desired performance objectives.

A New Multiconstraint Method for Determining the Optimal Cable Stresses in Cable-Stayed Bridges

PubMed Central

Asgari, B.; Osman, S. A.; Adnan, A.

2014-01-01

Cable-stayed bridges are one of the most popular types of long-span bridges. The structural behaviour of cable-stayed bridges is sensitive to the load distribution between the girder, pylons, and cables. The determination of pretensioning cable stresses is critical in the cable-stayed bridge design procedure. By finding the optimum stresses in cables, the load and moment distribution of the bridge can be improved. In recent years, different research works have studied iterative and modern methods to find optimum stresses of cables. However, most of the proposed methods have limitations in optimising the structural performance of cable-stayed bridges. This paper presents a multiconstraint optimisation method to specify the optimum cable forces in cable-stayed bridges. The proposed optimisation method produces less bending moments and stresses in the bridge members and requires shorter simulation time than other proposed methods. The results of comparative study show that the proposed method is more successful in restricting the deck and pylon displacements and providing uniform deck moment distribution than unit load method (ULM). The final design of cable-stayed bridges can be optimised considerably through proposed multiconstraint optimisation method. PMID:25050400

A new multiconstraint method for determining the optimal cable stresses in cable-stayed bridges.

PubMed

Asgari, B; Osman, S A; Adnan, A

2014-01-01

Cable-stayed bridges are one of the most popular types of long-span bridges. The structural behaviour of cable-stayed bridges is sensitive to the load distribution between the girder, pylons, and cables. The determination of pretensioning cable stresses is critical in the cable-stayed bridge design procedure. By finding the optimum stresses in cables, the load and moment distribution of the bridge can be improved. In recent years, different research works have studied iterative and modern methods to find optimum stresses of cables. However, most of the proposed methods have limitations in optimising the structural performance of cable-stayed bridges. This paper presents a multiconstraint optimisation method to specify the optimum cable forces in cable-stayed bridges. The proposed optimisation method produces less bending moments and stresses in the bridge members and requires shorter simulation time than other proposed methods. The results of comparative study show that the proposed method is more successful in restricting the deck and pylon displacements and providing uniform deck moment distribution than unit load method (ULM). The final design of cable-stayed bridges can be optimised considerably through proposed multiconstraint optimisation method.

Invited Commentary: Beware the Test-Negative Design.

PubMed

Westreich, Daniel; Hudgens, Michael G

2016-09-01

In this issue of the Journal, Sullivan et al. (Am J Epidemiol. 2016;184(5):345-353) carefully examine the theoretical justification for use of the test-negative design, a common observational study design, in assessing the effectiveness of influenza vaccination. Using modern causal inference methods (in particular, directed acyclic graphs), they describe different threats to the validity of inferences drawn about the effect of vaccination from test-negative design studies. These threats include confounding, selection bias, and measurement error in either the exposure or the outcome. While confounding and measurement error are common in observational studies, the potential for selection bias inherent in the test-negative design brings into question the validity of inferences drawn from such studies. © The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Astronomical Optical Interferometry. I. Methods and Instrumentation

NASA Astrophysics Data System (ADS)

Jankov, S.

2010-12-01

Previous decade has seen an achievement of large interferometric projects including 8-10m telescopes and 100m class baselines. Modern computer and control technology has enabled the interferometric combination of light from separate telescopes also in the visible and infrared regimes. Imaging with milli-arcsecond (mas) resolution and astrometry with micro-arcsecond (muas) precision have thus become reality. Here, I review the methods and instrumentation corresponding to the current state in the field of astronomical optical interferometry. First, this review summarizes the development from the pioneering works of Fizeau and Michelson. Next, the fundamental observables are described, followed by the discussion of the basic design principles of modern interferometers. The basic interferometric techniques such as speckle and aperture masking interferometry, aperture synthesis and nulling interferometry are disscused as well. Using the experience of past and existing facilities to illustrate important points, I consider particularly the new generation of large interferometers that has been recently commissioned (most notably, the CHARA, Keck, VLT and LBT Interferometers). Finally, I discuss the longer-term future of optical interferometry, including the possibilities of new large-scale ground-based projects and prospects for space interferometry.

[Computational chemistry in structure-based drug design].

PubMed

Cao, Ran; Li, Wei; Sun, Han-Zi; Zhou, Yu; Huang, Niu

2013-07-01

Today, the understanding of the sequence and structure of biologically relevant targets is growing rapidly and researchers from many disciplines, physics and computational science in particular, are making significant contributions to modern biology and drug discovery. However, it remains challenging to rationally design small molecular ligands with desired biological characteristics based on the structural information of the drug targets, which demands more accurate calculation of ligand binding free-energy. With the rapid advances in computer power and extensive efforts in algorithm development, physics-based computational chemistry approaches have played more important roles in structure-based drug design. Here we reviewed the newly developed computational chemistry methods in structure-based drug design as well as the elegant applications, including binding-site druggability assessment, large scale virtual screening of chemical database, and lead compound optimization. Importantly, here we address the current bottlenecks and propose practical solutions.

Designing high-quality interactive multimedia learning modules.

PubMed

Huang, Camillan

2005-01-01

Modern research has broadened scientific knowledge and revealed the interdisciplinary nature of the sciences. For today's students, this advance translates to learning a more diverse range of concepts, usually in less time, and without supporting resources. Students can benefit from technology-enhanced learning supplements that unify concepts and are delivered on-demand over the Internet. Such supplements, like imaging informatics databases, serve as innovative references for biomedical information, but could improve their interaction interfaces to support learning. With information from these digital datasets, multimedia learning tools can be designed to transform learning into an active process where students can visualize relationships over time, interact with dynamic content, and immediately test their knowledge. This approach bridges knowledge gaps, fosters conceptual understanding, and builds problem-solving and critical thinking skills-all essential components to informatics training for science and medicine. Additional benefits include cost-free access and ease of dissemination over the Internet or CD-ROM. However, current methods for the design of multimedia learning modules are not standardized and lack strong instructional design. Pressure from administrators at the top and students from the bottom are pushing faculty to use modern technology to address the learning needs and expectations of contemporary students. Yet, faculty lack adequate support and training to adopt this new approach. So how can faculty learn to create educational multimedia materials for their students? This paper provides guidelines on best practices in educational multimedia design, derived from the Virtual Labs Project at Stanford University. The development of a multimedia module consists of five phases: (1) understand the learning problem and the users needs; (2) design the content to harness the enabling technologies; (3) build multimedia materials with web style standards and human factors principles; (4) user testing; (5) evaluate and improve design.

Leaky Landfills.

ERIC Educational Resources Information Center

Jones, Linda L. Cronin

1992-01-01

Provides background information on landfills and describes an activity where students learn how a modern landfill is constructed and develop an understanding of the reasons for several regulations regarding modern landfill construction. Students design and construct working models of three types of landfills. (PR)

Rail Modernization Study

DOT National Transportation Integrated Search

1987-04-01

This study summarizes the results of a multi-year assessment of the rail transit and commuter rail systems. The work was based on an earlier study design effort. The purposes of the study were to determine the costs of upgrading and modernizing urban...

Analysis Reveals Impact of Road Grade on Vehicle Energy Use | News | NREL

Science.gov Websites

of modern automobiles is essential for designing increasingly efficient powertrains. In recent years more information, refer to the conference paper-Contribution of Road Grade to the Energy Use of Modern

7 CFR 1751.101 - General.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS SYSTEM PLANNING AND DESIGN CRITERIA, AND PROCEDURES State Telecommunications Modernization Plan... Plan must, at a minimum, apply to RUS Borrowers' wireline service areas. If a Modernization Plan is...

Rational Design of High-Number dsDNA Fragments Based on Thermodynamics for the Construction of Full-Length Genes in a Single Reaction.

PubMed

Birla, Bhagyashree S; Chou, Hui-Hsien

2015-01-01

Gene synthesis is frequently used in modern molecular biology research either to create novel genes or to obtain natural genes when the synthesis approach is more flexible and reliable than cloning. DNA chemical synthesis has limits on both its length and yield, thus full-length genes have to be hierarchically constructed from synthesized DNA fragments. Gibson Assembly and its derivatives are the simplest methods to assemble multiple double-stranded DNA fragments. Currently, up to 12 dsDNA fragments can be assembled at once with Gibson Assembly according to its vendor. In practice, the number of dsDNA fragments that can be assembled in a single reaction are much lower. We have developed a rational design method for gene construction that allows high-number dsDNA fragments to be assembled into full-length genes in a single reaction. Using this new design method and a modified version of the Gibson Assembly protocol, we have assembled 3 different genes from up to 45 dsDNA fragments at once. Our design method uses the thermodynamic analysis software Picky that identifies all unique junctions in a gene where consecutive DNA fragments are specifically made to connect to each other. Our novel method is generally applicable to most gene sequences, and can improve both the efficiency and cost of gene assembly.

The Modern Design of Experiments: A Technical and Marketing Framework

NASA Technical Reports Server (NTRS)

DeLoach, R.

2000-01-01

A new wind tunnel testing process under development at NASA Langley Research Center, called Modern Design of Experiments (MDOE), differs from conventional wind tunnel testing techniques on a number of levels. Chief among these is that MDOE focuses on the generation of adequate prediction models rather than high-volume data collection. Some cultural issues attached to this and other distinctions between MDOE and conventional wind tunnel testing are addressed in this paper.

Numeric Design and Performance Analysis of Solid Oxide Fuel Cell -- Gas Turbine Hybrids on Aircraft

NASA Astrophysics Data System (ADS)

Hovakimyan, Gevorg

The aircraft industry benefits greatly from small improvements in aircraft component design. One possible area of improvement is in the Auxiliary Power Unit (APU). Modern aircraft APUs are gas turbines located in the tail section of the aircraft that generate additional power when needed. Unfortunately the efficiency of modern aircraft APUs is low. Solid Oxide Fuel Cell/Gas Turbine (SOFC/GT) hybrids are one possible alternative for replacing modern gas turbine APUs. This thesis investigates the feasibility of replacing conventional gas turbine APUs with SOFC/GT APUs on aircraft. An SOFC/GT design algorithm was created in order to determine the specifications of an SOFC/GT APU. The design algorithm is comprised of several integrated modules which together model the characteristics of each component of the SOFC/GT system. Given certain overall inputs, through numerical analysis, the algorithm produces an SOFC/GT APU, optimized for specific power and efficiency, capable of performing to the required specifications. The SOFC/GT design is then input into a previously developed quasi-dynamic SOFC/GT model to determine its load following capabilities over an aircraft flight cycle. Finally an aircraft range study is conducted to determine the feasibility of the SOFC/GT APU as a replacement for the conventional gas turbine APU. The design results show that SOFC/GT APUs have lower specific power than GT systems, but have much higher efficiencies. Moreover, the dynamic simulation results show that SOFC/GT APUs are capable of following modern flight loads. Finally, the range study determined that SOFC/GT APUs are more attractive over conventional APUs for longer range aircraft.

Modernization of the Cassini Ground System

NASA Technical Reports Server (NTRS)

Razo, Gus; Fujii, Tammy J.

2014-01-01

The Cassini Spacecraft and its ground system have been operational for over 16 years. Modernization presents several challenges due to the personnel, processes, and tools already invested and embedded into the current ground system structure. Every mission's ground system has its own unique complexities and challenges, involving various organizational units. As any mission from its inception to its execution, schedules are always tight. This forces GDS engineers to implement a working ground system that is not necessarily fully optimized. Ground system challenges increase as technology evolves and cyber threats become more sophisticated. Cassini's main challenges were due to its ground system existing before many security requirements were levied on the multi-mission tools and networks. This caused a domino effect on Cassini GDS tools that relied on outdated technological features. In the aerospace industry reliable and established technology is preferred over innovative yet less proven technology. Loss of data for a spacecraft mission can be catastrophic; therefore, there is a reluctance to make changes and updates to the ground system. Nevertheless, all missions and associated teams face the need to modernize their processes and tools. Systems development methods from well-known system analysis and design principles can be applied to many missions' ground systems. Modernization should always be considered, but should be done in such a way that it does not affect flexibility nor interfere with established practices. Cassini has accomplished a secure and efficient ground data system through periodic updates. The obstacles faced while performing the modernization of the Cassini ground system will be outlined, as well as the advantages and challenges that were encountered.

Modular adaptive implant based on smart materials.

PubMed

Bîzdoacă, N; Tarniţă, Daniela; Tarniţă, D N

2008-01-01

Applications of biological methods and systems found in nature to the study and design of engineering systems and modern technology are defined as Bionics. The present paper describes a bionics application of shape memory alloy in construction of orthopedic implant. The main idea of this paper is related to design modular adaptive implants for fractured bones. In order to target the efficiency of medical treatment, the implant has to protect the fractured bone, for the healing period, undertaking much as is possible from the daily usual load of the healthy bones. After a particular stage of healing period is passed, using implant modularity, the load is gradually transferred to bone, assuring in this manner a gradually recover of bone function. The adaptability of this design is related to medical possibility of the physician to made the implant to correspond to patient specifically anatomy. Using a CT realistic numerical bone models, the mechanical simulation of different types of loading of the fractured bones treated with conventional method are presented. The results are commented and conclusions are formulated.

A new state space model for the NASA/JPL 70-meter antenna servo controls

NASA Technical Reports Server (NTRS)

Hill, R. E.

1987-01-01

A control axis referenced model of the NASA/JPL 70-m antenna structure is combined with the dynamic equations of servo components to produce a comprehansive state variable (matrix) model of the coupled system. An interactive Fortran program for generating the linear system model and computing its salient parameters is described. Results are produced in a state variable, block diagram, and in factored transfer function forms to facilitate design and analysis by classical as well as modern control methods.

Modern Technologies for Creating Synthetic Antibodies for Clinical application

PubMed Central

Lebedenko, E. N.

2009-01-01

The modular structure and versatility of antibodies enables one to modify natural immunoglobulins in different ways for various clinical applications. Rational design and molecular engineering make it possible to directionally modify the molecular size, affinity, specificity, and immunogenicity and effector functions of an antibody, as well as to combine them with other functional agents. This review focuses on up-to-date methods of antibody engineering for diagnosing and treating various diseases, particularly on new technologies meant to refine the effector functions of therapeutic antibodies. PMID:22649585

Genetic Algorithm Optimization of a Film Cooling Array on a Modern Turbine Inlet Vane

DTIC Science & Technology

2012-09-01

heater is typically higher than the test section temperature since there is a lag due to heat transfer to the piping between the heater and test... flexible substrate 301 used 50 microns thick and the gauges themselves are a platinum metal layer 500-Å thick. When subjected to a change in heat ...more advanced gas turbine cooling design methods that factor in the 3-D flowfield and heat transfer characteristics, this study involves the

Anaerobic digestion of municipal solid waste: Technical developments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rivard, C.J.

1996-01-01

The anaerobic biogasification of organic wastes generates two useful products: a medium-Btu fuel gas and a compost-quality organic residue. Although commercial-scale digestion systems are used to treat municipal sewage wastes, the disposal of solid organic wastes, including municipal solid wastes (MSW), requires a more cost-efficient process. Modern biogasification systems employ high-rate, high-solids fermentation methods to improve process efficiency and reduce capital costs. The design criteria and development stages are discussed. These systems are also compared with conventional low-solids fermentation technology.

Molecular Biology for the Environment: an EC-US hands-on Course in Environmental Biotechnology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Victor de Lorenzo; Juan Luis Ramos; Jerome Kukor

One of the central goals of this activity is to bring together young scientists (at the late Ph.D. or early postdoctoral stages of their careers) in a forum that should result in future collaborations. The course is designed to give scientists hands-on experience in modern, up-to-date biotechnological methods at the interface between molecular biology and environmental biotechnology for the analysis of microorganisms and their activities with regard to the remediation of pollutants in the environment.

Photovoltaic power system reliability considerations

NASA Technical Reports Server (NTRS)

Lalli, V. R.

1980-01-01

This paper describes an example of how modern engineering and safety techniques can be used to assure the reliable and safe operation of photovoltaic power systems. This particular application was for a solar cell power system demonstration project in Tangaye, Upper Volta, Africa. The techniques involve a definition of the power system natural and operating environment, use of design criteria and analysis techniques, an awareness of potential problems via the inherent reliability and FMEA methods, and use of a fail-safe and planned spare parts engineering philosophy.

Neural network expert system for X-ray analysis of welded joints

NASA Astrophysics Data System (ADS)

Kozlov, V. V.; Lapik, N. V.; Popova, N. V.

2018-03-01

The use of intelligent technologies for the automated analysis of product quality is one of the main trends in modern machine building. At the same time, rapid development in various spheres of human activity is experienced by methods associated with the use of artificial neural networks, as the basis for building automated intelligent diagnostic systems. Technologies of machine vision allow one to effectively detect the presence of certain regularities in the analyzed designation, including defects of welded joints according to radiography data.

Natural photonics for industrial inspiration.

PubMed

Parker, Andrew R

2009-05-13

There are two considerations for optical biomimetics: the diversity of submicrometre architectures found in the natural world, and the industrial manufacture of these. A review exists on the latter subject, where current engineering methods are considered along with those of the natural cells. Here, on the other hand, I will provide a modern review of the different categories of reflectors and antireflectors found in animals, including their optical characterization. The purpose of this is to inspire designers within the $2 billion annual optics industry.

Structural Optimization of a Force Balance Using a Computational Experiment Design

NASA Technical Reports Server (NTRS)

Parker, P. A.; DeLoach, R.

2002-01-01

This paper proposes a new approach to force balance structural optimization featuring a computational experiment design. Currently, this multi-dimensional design process requires the designer to perform a simplification by executing parameter studies on a small subset of design variables. This one-factor-at-a-time approach varies a single variable while holding all others at a constant level. Consequently, subtle interactions among the design variables, which can be exploited to achieve the design objectives, are undetected. The proposed method combines Modern Design of Experiments techniques to direct the exploration of the multi-dimensional design space, and a finite element analysis code to generate the experimental data. To efficiently search for an optimum combination of design variables and minimize the computational resources, a sequential design strategy was employed. Experimental results from the optimization of a non-traditional force balance measurement section are presented. An approach to overcome the unique problems associated with the simultaneous optimization of multiple response criteria is described. A quantitative single-point design procedure that reflects the designer's subjective impression of the relative importance of various design objectives, and a graphical multi-response optimization procedure that provides further insights into available tradeoffs among competing design objectives are illustrated. The proposed method enhances the intuition and experience of the designer by providing new perspectives on the relationships between the design variables and the competing design objectives providing a systematic foundation for advancements in structural design.

Modern contraceptive use among women in the Asuogyaman district of Ghana: is reliability more important than health concerns?

PubMed

Teye, Joseph Kofi

2013-06-01

This study examines the socio-demographic determinants of modern contraceptive use among women in the Asuogyaman district of Ghana. The results reveal that although 97% of the survey respondents knew of at least one modern method of contraception, only 16% of them were using modern contraceptives. Statistical tests show that level of education, place of residence, and work status significantly influence modern contraceptive use among women in the study area. Fear of side effects, desire for more children, and partner's disapproval were the main barriers to modern contraceptive use in the study area. The use of traditional methods of contraception was very high because of the perception that they are safer. Based on these findings, it has been suggested that in addition to making family planning services available and accessible, health workers must address attitudinal factors such as fear of side effects and high fertility preferences.

Industrial Technology Modernization Program. Project 28. Automation of Receiving, Receiving Inspection and Stores

DTIC Science & Technology

1987-06-15

001 GENERAL DYNAMICS 00 FORT WORTH DIVISION INDUSTRIAL TECHNOLOGY MODERNIZATION PROGRAM Phase 2 Final Project Repc t JUNG 0 ?7 PROJECT 28 AUTOMATION...DYNAMICS FORT WORTH DIVISION INDUSTRIAL TECHNOLOGY MODERNIZATION PROGRAM Phase 2 Final Project Report PROJECT 28 AUTOMATION OF RECEIVING, RECEIVING...13 6 PROJECT ASSUMPTIONS 20 7 PRELIMINARY/FINAL DESIGN AND FINDINGS 21 8 SYSTEM/EQUIPMENT/MACHINING SPECIFICATIONS 37 9 VENDOR/ INDUSTRY ANALYSIS

Global Design Optimization for Aerodynamics and Rocket Propulsion Components

NASA Technical Reports Server (NTRS)

Shyy, Wei; Papila, Nilay; Vaidyanathan, Rajkumar; Tucker, Kevin; Turner, James E. (Technical Monitor)

2000-01-01

Modern computational and experimental tools for aerodynamics and propulsion applications have matured to a stage where they can provide substantial insight into engineering processes involving fluid flows, and can be fruitfully utilized to help improve the design of practical devices. In particular, rapid and continuous development in aerospace engineering demands that new design concepts be regularly proposed to meet goals for increased performance, robustness and safety while concurrently decreasing cost. To date, the majority of the effort in design optimization of fluid dynamics has relied on gradient-based search algorithms. Global optimization methods can utilize the information collected from various sources and by different tools. These methods offer multi-criterion optimization, handle the existence of multiple design points and trade-offs via insight into the entire design space, can easily perform tasks in parallel, and are often effective in filtering the noise intrinsic to numerical and experimental data. However, a successful application of the global optimization method needs to address issues related to data requirements with an increase in the number of design variables, and methods for predicting the model performance. In this article, we review recent progress made in establishing suitable global optimization techniques employing neural network and polynomial-based response surface methodologies. Issues addressed include techniques for construction of the response surface, design of experiment techniques for supplying information in an economical manner, optimization procedures and multi-level techniques, and assessment of relative performance between polynomials and neural networks. Examples drawn from wing aerodynamics, turbulent diffuser flows, gas-gas injectors, and supersonic turbines are employed to help demonstrate the issues involved in an engineering design context. Both the usefulness of the existing knowledge to aid current design practices and the need for future research are identified.

42 CFR 124.1 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-10-01

... FACILITY CONSTRUCTION AND MODERNIZATION Project Grants for Public Medical Facility Construction and... of the Public Health Service Act for construction and modernization projects designed to: (a) Eliminate or prevent imminent safety hazards as defined by Federal, State or local fire, building, or life...

Design of a Smart Ultrasonic Transducer for Interconnecting Machine Applications

PubMed Central

Yan, Tian-Hong; Wang, Wei; Chen, Xue-Dong; Li, Qing; Xu, Chang

2009-01-01

A high-frequency ultrasonic transducer for copper or gold wire bonding has been designed, analyzed, prototyped and tested. Modeling techniques were used in the design phase and a practical design procedure was established and used. The transducer was decomposed into its elementary components. For each component, an initial design was obtained with simulations using a finite elements model (FEM). Simulated ultrasonic modules were built and characterized experimentally through the Laser Doppler Vibrometer (LDV) and electrical resonance spectra. Compared with experimental data, the FEM could be iteratively adjusted and updated. Having achieved a remarkably highly-predictive FEM of the whole transducer, the design parameters could be tuned for the desired applications, then the transducer is fixed on the wire bonder with a complete holder clamping was calculated by the FEM. The approach to mount ultrasonic transducers on wire bonding machines also is of major importance for wire bonding in modern electronic packaging. The presented method can lead to obtaining a nearly complete decoupling clamper design of the transducer to the wire bonder. PMID:22408564

Using Program Data to Improve Access to Family Planning and Enhance the Method Mix in Conflict-Affected Areas of the Democratic Republic of the Congo

PubMed Central

Ho, Lara S; Wheeler, Erin

2018-01-01

Unmet need for family planning in the conflict-affected area of eastern Democratic Republic of the Congo (DRC) has been reported to be as high as 38%, and women in such conflict settings are often the most at risk for maternal mortality. The International Rescue Committee implements the Family Planning and Post-Abortion Care in Emergencies program in 3 provinces of eastern DRC to provide women and couples access to family planning, including long-acting reversible contraceptives (LARCs). This article presents routine program data from June 2011 through December 2013 from 2 health zones as well as results from a qualitative assessment of family planning clients and of male and female non-users, conducted in 2013. It then describes how these findings were used to make program adjustments to improve access to family planning services and client informed choice and assesses the effects of the program design changes on family planning uptake and method mix using routine program data from January 2014 through December 2016. Between 2011 and 2013, 8,985 clients adopted family planning, with an average 14 clients adopting a method per facility, per month. The method mix remained stable during this period, with implants dominating at 48%. Barriers to uptake identified from the qualitative research were both supply- and demand-related, including misconceptions about certain modern contraceptive methods on the part of providers, users, and other community members. The program implemented several program changes based on the assessment findings, including clinical coaching and supportive supervision to improve provider skills and attitudes, introduction of immediate postpartum insertion of the intrauterine device (IUD) and the levonorgestrel-releasing intrauterine system (LNG-IUS), and behavior change communication campaigns to raise awareness about family planning. After these program changes, the mean number of clients adopting modern family planning per facility, per month increased from 14 to 37 and the percentage of family planning adopters choosing LARCs increased from 50% to 66%. While implants continued to be the most dominant method, reaching 60% of the method mix in 2016, the percentage of clients adopting IUDs increased each year, from 3% in 2014 to 13% in 2016. In total, 39,399 clients started family planning methods during the post-program design change period (2014–2016). Our experience in eastern DRC demonstrates that women and their partners affected by conflict want family planning, and that it is feasible to deliver the full range of modern contraceptive methods when programs are adapted and sensitive to the local context. PMID:29602870

QGene 4.0, an extensible Java QTL-analysis platform.

PubMed

Joehanes, Roby; Nelson, James C

2008-12-01

Of many statistical methods developed to date for quantitative trait locus (QTL) analysis, only a limited subset are available in public software allowing their exploration, comparison and practical application by researchers. We have developed QGene 4.0, a plug-in platform that allows execution and comparison of a variety of modern QTL-mapping methods and supports third-party addition of new ones. The software accommodates line-cross mating designs consisting of any arbitrary sequence of selfing, backcrossing, intercrossing and haploid-doubling steps that includes map, population, and trait simulators; and is scriptable. Software and documentation are available at http://coding.plantpath.ksu.edu/qgene. Source code is available on request.

[Genomics innovative teaching pattern based upon amalgamation between modern educational technology and constructivism studying theory].

PubMed

Liang, Xu-Fang; Peng, Jing; Zhou, Tian-Hong

2007-04-01

In order to overcome various malpractices in the traditional teaching methods, and also as part of the Guangdong province molecular biology perfect course project, some reforms were carried out to the teaching pattern of genomics. The reforms include using the foreign original teaching materials, bilingual teaching, as well as taking the constructivism-directed discussion teaching method and the multimedia computer-assisted instruction. To improve the scoring way and the laboratory course of the subject, we carried on a multiplex inspection systems and a self-designing experiments. Through the teaching reform on Genomics, we have gradually consummated the construction of molecular biology curriculum system.

Counter sniper: a localization system based on dual thermal imager

NASA Astrophysics Data System (ADS)

He, Yuqing; Liu, Feihu; Wu, Zheng; Jin, Weiqi; Du, Benfang

2010-11-01

Sniper tactics is widely used in modern warfare, which puts forward the urgent requirement of counter sniper detection devices. This paper proposed the anti-sniper detection system based on a dual-thermal imaging system. Combining the infrared characteristics of the muzzle flash and bullet trajectory of binocular infrared images obtained by the dual-infrared imaging system, the exact location of the sniper was analyzed and calculated. This paper mainly focuses on the system design method, which includes the structure and parameter selection. It also analyzes the exact location calculation method based on the binocular stereo vision and image analysis, and give the fusion result as the sniper's position.

The self-regulating brain and neurofeedback: Experimental science and clinical promise.

PubMed

Thibault, Robert T; Lifshitz, Michael; Raz, Amir

2016-01-01

Neurofeedback, one of the primary examples of self-regulation, designates a collection of techniques that train the brain and help to improve its function. Since coming on the scene in the 1960s, electroencephalography-neurofeedback has become a treatment vehicle for a host of mental disorders; however, its clinical effectiveness remains controversial. Modern imaging technologies of the living human brain (e.g., real-time functional magnetic resonance imaging) and increasingly rigorous research protocols that utilize such methodologies begin to shed light on the underlying mechanisms that may facilitate more effective clinical applications. In this paper we focus on recent technological advances in the field of human brain imaging and discuss how these modern methods may influence the field of neurofeedback. Toward this end, we outline the state of the evidence and sketch out future directions to further explore the potential merits of this contentious therapeutic prospect. Copyright © 2015 Elsevier Ltd. All rights reserved.

[Modern approaches to the use of neurotropic physical therapy in arterial hypertension].

PubMed

Orekhova, E M; Konchugova, T V; Kul'chitskaya, D B; Korchazhkina, N B; Egorova, L A; Chuich, N G

2016-01-01

The development and introduction into clinical practice of non-pharmacological methods for the prevention and treatment of arterial hypertension is a primary objective of modern physical therapy, especially as regards the neurotropic influences. This article was designed to report the results of the investigation into the hypotensive effect of transcerebral magnetic therapy obtained during the treatment of 60 patients presenting with arterial hypertension. The study included the comparative examination of two randomly formed groups containing 30 patients each. The patients of the main group received transcerebral magnetic therapy (to the frontal region) while those in the group of comparison were given magnetotherapy at the collar region. The study has demonstrated that transcerebral magnetic therapy given to the patients of the main group was a more efficient treatment than magnetotherapy at the collar region since it produced a more pronounced hypotensive effect irrespective of the initial hemodynamic type.

Predictors of modern contraceptive methods use among married women of reproductive age groups in Western Ethiopia: a community based cross-sectional study.

PubMed

Tekelab, Tesfalidet; Melka, Alemu Sufa; Wirtu, Desalegn

2015-07-17

In Ethiopia, the prevalence of modern contraceptive use is very low (27 %) and the percentage of those with unmet needs for family planning is 25 %. The current study identified factors associated with the utilization of modern contraceptive methods among married women in Western Ethiopia. A community based, cross-sectional study was employed from April 10 to April 25, 2014, among married women of reproductive age in Nekemte Town. A multi-stage sampling procedure was used to select 1003 study participants. A pretested structured questionnaire was used to collect data, and data collectors who had completed high school were involved in the data collection process. A bivariate, multivariable logistic regression model was fit, and statistical significance was determined with a 95% confidence level. The overall utilization rate of modern contraceptives in this study was 71.9%. The most common form of modern contraceptives used was injectable (60.3%). Age (AOR = 2.00, 95 % CI = 1.35-2.98), women's educational level (AOR = 2.50, 95 % CI = 1.62-3.84), monthly income (AOR = 2.26, 95 % CI = 1.24-4.10), respondent's fertility (AOR = 2.60, 95 % CI = 1.48-4.56), fertility-related decision (AOR = 3.70, 95 % CI = 2.45-5.58), and having radio (AOR = 1.93, 95 % CI = 1.37-2.71) showed significant positive associations with the utilization of modern contraceptive methods. The findings showed that women's empowerment, fertility-related discussions among couples, and the availability of the media were important factors that influenced the use of modern contraceptives. Thus, policymakers and implementers should work on those factors to increase the utilization of modern contraceptive methods.

[Discussion on knowledge structural system of modern acupuncture professionals].

PubMed

Wang, Qin-Yu; Li, Su-He

2012-02-01

To explore the knowledge structural system that the modern acupuncture professionals should have. The current situation of personnel training for modern acupuncture professionals was multi-dimensionally and comprehensively analyzed from course offering of higher education, laws of famous physicians growth, and discipline development features of the acupuncture and moxibustion subject, and suggestions were made to the shortages. The reasonable knowledge structural system that the modern acupuncture professionals should have included establishment of good Chinese medicine thoughts, mastery of complete Chinese medicine therapy, and ability of followup of dynamic development of subject. The reformation of course design is imperative in order to promote the reasonable knowledge structural system formation of modern acupuncture professionals.

A high-precision velocity measuring system design for projectiles based on S-shaped laser screen

NASA Astrophysics Data System (ADS)

Liu, Huayi; Qian, Zheng; Yu, Hao; Li, Yutao

2018-03-01

The high-precision measurement of the velocity of high-speed flying projectile is of great significance for the evaluation and development of modern weapons. The velocity of the high-speed flying projectile is usually measured by laser screen velocity measuring system. But this method cannot achieve the repeated measurements, so we cannot make an indepth evaluation of the uncertainty about the measuring system. This paper presents a design based on S-shaped laser screen velocity measuring system. This design can achieve repeated measurements. Therefore, it can effectively reduce the uncertainty of the velocity measuring system. In addition, we made a detailed analysis of the uncertainty of the measuring system. The measurement uncertainty is 0.2% when the velocity of the projectile is about 200m/s.

JSC Metal Finishing Waste Minimization Methods

NASA Technical Reports Server (NTRS)

Sullivan, Erica

2003-01-01

THe paper discusses the following: Johnson Space Center (JSC) has achieved VPP Star status and is ISO 9001 compliant. The Structural Engineering Division in the Engineering Directorate is responsible for operating the metal finishing facility at JSC. The Engineering Directorate is responsible for $71.4 million of space flight hardware design, fabrication and testing. The JSC Metal Finishing Facility processes flight hardware to support the programs in particular schedule and mission critical flight hardware. The JSC Metal Finishing Facility is operated by Rothe Joint Venture. The Facility provides following processes: anodizing, alodining, passivation, and pickling. JSC Metal Finishing Facility completely rebuilt in 1998. Total cost of $366,000. All new tanks, electrical, plumbing, and ventilation installed. Designed to meet modern safety, environmental, and quality requirements. Designed to minimize contamination and provide the highest quality finishes.

The Physics and Mathematics of MRI

NASA Astrophysics Data System (ADS)

Ansorge, Richard; Graves, Martin

2016-10-01

Magnetic Resonance Imaging is a very important clinical imaging tool. It combines different fields of physics and engineering in a uniquely complex way. MRI is also surprisingly versatile, `pulse sequences' can be designed to yield many different types of contrast. This versatility is unique to MRI. This short book gives both an in depth account of the methods used for the operation and construction of modern MRI systems and also the principles of sequence design and many examples of applications. An important additional feature of this book is the detailed discussion of the mathematical principles used in building optimal MRI systems and for sequence design. The mathematical discussion is very suitable for undergraduates attending medical physics courses. It is also more complete than usually found in alternative books for physical scientists or more clinically orientated works.

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCarthy, J.M.

The theory and methodology of design of general-purpose machines that may be controlled by a computer to perform all the tasks of a set of special-purpose machines is the focus of modern machine design research. These seventeen contributions chronicle recent activity in the analysis and design of robot manipulators that are the prototype of these general-purpose machines. They focus particularly on kinematics, the geometry of rigid-body motion, which is an integral part of machine design theory. The challenges to kinematics researchers presented by general-purpose machines such as the manipulator are leading to new perspectives in the design and control ofmore » simpler machines with two, three, and more degrees of freedom. Researchers are rethinking the uses of gear trains, planar mechanisms, adjustable mechanisms, and computer controlled actuators in the design of modern machines.« less

Integrated Approach to Industrial Packaging Design

NASA Astrophysics Data System (ADS)

Vorobeva, O.

2017-11-01

The article reviews studies in the field of industrial packaging design. The major factors which influence technological, ergonomic, economic and ecological features of packaging are established. The main modern trends in packaging design are defined, the principles of marketing communications and their influence on consumers’ consciousness are indicated, and the function of packaging as a transmitter of brand values is specified. Peculiarities of packaging technology and printing techniques in modern printing industry are considered. The role of designers in the stage-by-stage development of the construction, form and graphic design concept of packaging is defined. The examples of authentic packaging are given and the mention of the tetrahedron packaging history is made. At the end of the article, conclusions on the key research aspects are made.

Peer-driven contraceptive choices and preferences for contraceptive methods among students of tertiary educational institutions in Enugu, Nigeria.

PubMed

Iyoke, Ca; Ezugwu, Fo; Lawani, Ol; Ugwu, Go; Ajah, Lo; Mba, Sg

2014-01-01

To describe the methods preferred for contraception, evaluate preferences and adherence to modern contraceptive methods, and determine the factors associated with contraceptive choices among tertiary students in South East Nigeria. A questionnaire-based cross-sectional study of sexual habits, knowledge of contraceptive methods, and patterns of contraceptive choices among a pooled sample of unmarried students from the three largest tertiary educational institutions in Enugu city, Nigeria was done. Statistical analysis involved descriptive and inferential statistics at the 95% level of confidence. A total of 313 unmarried students were studied (194 males; 119 females). Their mean age was 22.5±5.1 years. Over 98% of males and 85% of females made their contraceptive choices based on information from peers. Preferences for contraceptive methods among female students were 49.2% for traditional methods of contraception, 28% for modern methods, 10% for nonpharmacological agents, and 8% for off-label drugs. Adherence to modern contraceptives among female students was 35%. Among male students, the preference for the male condom was 45.2% and the adherence to condom use was 21.7%. Multivariate analysis showed that receiving information from health personnel/media/workshops (odds ratio 9.54, 95% confidence interval 3.5-26.3), health science-related course of study (odds ratio 3.5, 95% confidence interval 1.3-9.6), and previous sexual exposure prior to university admission (odds ratio 3.48, 95% confidence interval 1.5-8.0) all increased the likelihood of adherence to modern contraceptive methods. An overwhelming reliance on peers for contraceptive information in the context of poor knowledge of modern methods of contraception among young people could have contributed to the low preferences and adherence to modern contraceptive methods among students in tertiary educational institutions. Programs to reduce risky sexual behavior among these students may need to focus on increasing the content and adequacy of contraceptive information held by people through regular health worker-led, on-campus workshops.

Problems in creation of modern air inlet filters of power gas turbine plants in Russia and methods of their solving

NASA Astrophysics Data System (ADS)

Mikhaylov, V. E.; Khomenok, L. A.; Sherapov, V. V.

2016-08-01

The main problems in creation and operation of modern air inlet paths of gas turbine plants installed as part of combined-cycle plants in Russia are presented. It is noted that design features of air inlet filters shall be formed at the stage of the technical assignment not only considering the requirements of gas turbine plant manufacturer but also climatic conditions, local atmospheric air dustiness, and a number of other factors. The recommendations on completing of filtration system for air inlet filter of power gas turbine plants depending on the facility location are given, specific defects in design and experience in operation of imported air inlet paths are analyzed, and influence of cycle air preparation quality for gas turbine plant on value of operating expenses and cost of repair works is noted. Air treatment equipment of various manufacturers, influence of aerodynamic characteristics on operation of air inlet filters, features of filtration system operation, anti-icing system, weather canopies, and other elements of air inlet paths are considered. It is shown that nonuniformity of air flow velocity fields in clean air chamber has a negative effect on capacity and aerodynamic resistance of air inlet filter. Besides, the necessity in installation of a sufficient number of differential pressure transmitters allowing controlling state of each treatment stage not being limited to one measurement of total differential pressure in the filtration system is noted in the article. According to the results of the analysis trends and methods for modernization of available equipment for air inlet path, the importance of creation and implementation of new technologies for manufacturing of filtering elements on sites of Russia within the limits of import substitution are given, and measures on reliability improvement and energy efficiency for air inlet filter are considered.

A test of Hartnett's revisions to the pubic symphysis and fourth rib methods on a modern sample.

PubMed

Merritt, Catherine E

2014-05-01

Estimating age at death is one of the most important aspects of creating a biological profile. Most adult age estimation methods were developed on North American skeletal collections from the early to mid-20th century, and their applicability to modern populations has been questioned. In 2010, Hartnett used a modern skeletal collection from the Maricopia County Forensic Science Centre to revise the Suchey-Brooks pubic symphysis method and the İşcan et al. fourth rib methods. The current study tests Hartnett's revised methods as well as the original Suchey-Brooks and İşcan et al. methods on a modern sample from the William Bass Skeletal Collection (N = 313, mean age = 58.5, range 19-92). Results show that the Suchey-Brooks and İşcan et al. methods assign individuals to the correct phase 70.8% and 57.5% of the time compared with Hartnett's revised methods at 58.1% and 29.7%, respectively, with correctness scores based on one standard deviation of the mean rather than the entire age range. Accuracy and bias scores are significantly improved for Hartnett's revised pubic symphysis method and marginally better for Hartnett's revised fourth rib method, suggesting that the revised mean ages at death of Hartnett's phases better reflect this modern population. Overall, both Hartnett's revised methods are reliable age estimation methods. For the pubic symphysis, there are significant improvements in accuracy and bias scores, especially for older individuals; however, for the fourth rib, the results are comparable to the original İşcan et al. methods, with some improvement for older individuals. © 2014 American Academy of Forensic Sciences.

Modern Role of Architectural Style Category in Russian Practice

NASA Astrophysics Data System (ADS)

Chudinova, V. G.

2017-11-01

The article examines the functional aspects of architectural style use as an instrument for communication, self-positioning, representation and commercial attractiveness. The modern Russian practice is marked by a predominance of decorating methods rather than architectural ones used to create an artistic image. Specific examples illustrate stylistic trends that are indicative of an identity crisis. The problem goes beyond the scope of a custom or corporate design. This is especially evident in the former Soviet Union republics. The style issue is inherent in the advertising and commercial sphere of interior design and furnishing promotion. One can state that the category of art studies has been introduced into the collective consciousness but in some extrinsic way. Marketing managers and designers who have a very vague idea of the fundamental scientific concepts form a new language and market demand not only for a design work product but also for its positioning. This leads to a semantic distortion of the architectural style characteristic and a misconception. At the same time, there is a growing need for new definitions and verbalizations of perceptual experience. The conclusions contain an assumption on a reversible scientific and practical process when the theory is forced to accept and attend to a spontaneously formed and deep-rooted system of meanings. The need to develop the architectural theory in the communication language realm is brought up. The research problem is stated both for social science and anthropology as well as for culturology and art history.

Modelling of teeth of a gear transmission for modern manufacturing technologies

NASA Astrophysics Data System (ADS)

Monica, Z.; Banaś, W.; Ćwikla, G.; Topolska, S.

2017-08-01

The technological process of manufacturing of gear wheels is influenced by many factors. It is designated depending on the type of material from which the gear is to be produced, its heat treatment parameters, the required accuracy, the geometrical form and the modifications of the tooth. Therefor the parameters selection process is not easy and moreover it is unambiguous. Another important stage of the technological process is the selection of appropriate tools to properly machine teeth in the operations of both roughing and finishing. In the presented work the focus is put first of all on modern production methods of gears using technologically advanced instruments in comparison with conventional tools. Conventional processing tools such as gear hobbing cutters or Fellows gear-shaper cutters are used from the beginning of the machines for the production of gear wheels. With the development of technology and the creation of CNC machines designated for machining of gears wheel it was also developed the manufacturing technology as well as the design knowledge concerning the technological tools. Leading manufacturers of cutting tools extended the range of tools designated for machining of gears on the so-called hobbing cutters with inserted cemented carbide tips. The same have be introduced to Fellows gear-shaper cutters. The results of tests show that is advantaged to use hobbing cutters with inserted cemented carbide tips for milling gear wheels with a high number of teeth, where the time gains are very high, in relation to the use of conventional milling cutters.

The Galileo scan platform pointing control system - A modern control theoretic viewpoint

NASA Technical Reports Server (NTRS)

Sevaston, G. E.; Macala, G. A.; Man, G. K.

1985-01-01

The current Galileo scan platform pointing control system (SPPCS) is described, and ways in which modern control concepts could serve to enhance it are considered. Of particular interest are: the multi-variable design model and overall control system architecture, command input filtering, feedback compensator and command input design, stability robustness constraint for both continuous time control systems and for sampled data control systems, and digital implementation of the control system. The proposed approach leads to the design of a system that is similar to current Galileo SPPCS configuration, but promises to be more systematic.

Design and Test of Fan/Nacelle Models Quiet High-Speed Fan

NASA Technical Reports Server (NTRS)

Miller, Christopher J. (Technical Monitor); Weir, Donald

2003-01-01

The Quiet High-Speed Fan program is a cooperative effort between Honeywell Engines & Systems (formerly AlliedSignal Engines & Systems) and the NASA Glenn Research Center. Engines & Systems has designed an advanced high-speed fan that will be tested on the Ultra High Bypass Propulsion Simulator in the NASA Glenn 9 x 15 foot wind tunnel, currently scheduled for the second quarter of 2000. An Engines & Systems modern fan design will be used as a baseline. A nacelle model is provided that is characteristic of a typical, modern regional aircraft nacelle and meets all of the program test objectives.

Verification and Validation of Digitally Upgraded Control Rooms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boring, Ronald; Lau, Nathan

2015-09-01

As nuclear power plants undertake main control room modernization, a challenge is the lack of a clearly defined human factors process to follow. Verification and validation (V&V) as applied in the nuclear power community has tended to involve efforts such as integrated system validation, which comes at the tail end of the design stage. To fill in guidance gaps and create a step-by-step process for control room modernization, we have developed the Guideline for Operational Nuclear Usability and Knowledge Elicitation (GONUKE). This approach builds on best practices in the software industry, which prescribe an iterative user-centered approach featuring multiple cyclesmore » of design and evaluation. Nuclear regulatory guidance for control room design emphasizes summative evaluation—which occurs after the design is complete. In the GONUKE approach, evaluation is also performed at the formative stage of design—early in the design cycle using mockups and prototypes for evaluation. The evaluation may involve expert review (e.g., software heuristic evaluation at the formative stage and design verification against human factors standards like NUREG-0700 at the summative stage). The evaluation may also involve user testing (e.g., usability testing at the formative stage and integrated system validation at the summative stage). An additional, often overlooked component of evaluation is knowledge elicitation, which captures operator insights into the system. In this report we outline these evaluation types across design phases that support the overall modernization process. The objective is to provide industry-suitable guidance for steps to be taken in support of the design and evaluation of a new human-machine interface (HMI) in the control room. We suggest the value of early-stage V&V and highlight how this early-stage V&V can help improve the design process for control room modernization. We argue that there is a need to overcome two shortcomings of V&V in current practice—the propensity for late-stage V&V and the use of increasingly complex psychological assessment measures for V&V.« less

Mathematical biology modules based on modern molecular biology and modern discrete mathematics.

PubMed

Robeva, Raina; Davies, Robin; Hodge, Terrell; Enyedi, Alexander

2010-01-01

We describe an ongoing collaborative curriculum materials development project between Sweet Briar College and Western Michigan University, with support from the National Science Foundation. We present a collection of modules under development that can be used in existing mathematics and biology courses, and we address a critical national need to introduce students to mathematical methods beyond the interface of biology with calculus. Based on ongoing research, and designed to use the project-based-learning approach, the modules highlight applications of modern discrete mathematics and algebraic statistics to pressing problems in molecular biology. For the majority of projects, calculus is not a required prerequisite and, due to the modest amount of mathematical background needed for some of the modules, the materials can be used for an early introduction to mathematical modeling. At the same time, most modules are connected with topics in linear and abstract algebra, algebraic geometry, and probability, and they can be used as meaningful applied introductions into the relevant advanced-level mathematics courses. Open-source software is used to facilitate the relevant computations. As a detailed example, we outline a module that focuses on Boolean models of the lac operon network.

Mathematical Biology Modules Based on Modern Molecular Biology and Modern Discrete Mathematics

PubMed Central

Davies, Robin; Hodge, Terrell; Enyedi, Alexander

2010-01-01

We describe an ongoing collaborative curriculum materials development project between Sweet Briar College and Western Michigan University, with support from the National Science Foundation. We present a collection of modules under development that can be used in existing mathematics and biology courses, and we address a critical national need to introduce students to mathematical methods beyond the interface of biology with calculus. Based on ongoing research, and designed to use the project-based-learning approach, the modules highlight applications of modern discrete mathematics and algebraic statistics to pressing problems in molecular biology. For the majority of projects, calculus is not a required prerequisite and, due to the modest amount of mathematical background needed for some of the modules, the materials can be used for an early introduction to mathematical modeling. At the same time, most modules are connected with topics in linear and abstract algebra, algebraic geometry, and probability, and they can be used as meaningful applied introductions into the relevant advanced-level mathematics courses. Open-source software is used to facilitate the relevant computations. As a detailed example, we outline a module that focuses on Boolean models of the lac operon network. PMID:20810955

Multi-spectral fiber spectroscopy in 0,4-16μm range for biomedical applications(Conference Presentation)

NASA Astrophysics Data System (ADS)

Artyushenko, Viacheslav

2017-02-01

Various biomedical applications of fiber optics in a broad spectral range 0,4-16μm span from endoscopic imaging and Photo Dynamic Diagnostics (PDD) to laser power delivery for minimal invasive laser surgery, tissue coagulation and welding, Photo Dynamic Therapy (PDT), etc. Present review will highlight the latest results in advanced fiber solutions for a precise tissue diagnostics and control of some therapy methods - for so called "theranostic". Spectral fiber sensing for label free analysis of tissue composition helps to differentiate malignant and normal tissue to secure minimal invasive, but complete tumor removal or treatment. All key methods of Raman, fluorescence, diffuse reflection & MIR-absorption spectroscopy will be compared when used for the same spot of tissue - to select the most specific, sensitive and accurate method or to combine them for the synergy enhanced effect. The most informative spectral features for distinct organs/ tumor can be used to design special fiber sensors to be developed for portable and low cost applications with modern IT-features. Examples of multi-spectral tissue diagnostics promising for the future clinical applications will be presented to enable reduced mortality from cancer in the future. Translation of described methods into clinical practice will be discussed in comparison with the other method of optical diagnostics which should enhance modern medicine by less invasive, more precise and more effective methods of therapy to be fused with in-vivo diagnostics sensors & systems.

7 CFR 1751.105 - Amending a Modernization Plan.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Amending a Modernization Plan. 1751.105 Section 1751.105 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS SYSTEM PLANNING AND DESIGN CRITERIA, AND PROCEDURES State...

Integrated Aeroservoelastic Optimization: Status and Direction

NASA Technical Reports Server (NTRS)

Livne, Eli

1999-01-01

The interactions of lightweight flexible airframe structures, steady and unsteady aerodynamics, and wide-bandwidth active controls on modern airplanes lead to considerable multidisciplinary design challenges. More than 25 years of mathematical and numerical methods' development, numerous basic research studies, simulations and wind-tunnel tests of simple models, wind-tunnel tests of complex models of real airplanes, as well as flight tests of actively controlled airplanes, have all contributed to the accumulation of a substantial body of knowledge in the area of aeroservoelasticity. A number of analysis codes, with the capabilities to model real airplane systems under the assumptions of linearity, have been developed. Many tests have been conducted, and results were correlated with analytical predictions. A selective sample of references covering aeroservoelastic testing programs from the 1960s to the early 1980s, as well as more recent wind-tunnel test programs of real or realistic configurations, are included in the References section of this paper. An examination of references 20-29 will reveal that in the course of development (or later modification), of almost every modern airplane with a high authority active control system, there arose a need to face aeroservoelastic problems and aeroservoelastic design challenges.

Wind Tunnel Database Development using Modern Experiment Design and Multivariate Orthogonal Functions

NASA Technical Reports Server (NTRS)

Morelli, Eugene A.; DeLoach, Richard

2003-01-01

A wind tunnel experiment for characterizing the aerodynamic and propulsion forces and moments acting on a research model airplane is described. The model airplane called the Free-flying Airplane for Sub-scale Experimental Research (FASER), is a modified off-the-shelf radio-controlled model airplane, with 7 ft wingspan, a tractor propeller driven by an electric motor, and aerobatic capability. FASER was tested in the NASA Langley 12-foot Low-Speed Wind Tunnel, using a combination of traditional sweeps and modern experiment design. Power level was included as an independent variable in the wind tunnel test, to allow characterization of power effects on aerodynamic forces and moments. A modeling technique that employs multivariate orthogonal functions was used to develop accurate analytic models for the aerodynamic and propulsion force and moment coefficient dependencies from the wind tunnel data. Efficient methods for generating orthogonal modeling functions, expanding the orthogonal modeling functions in terms of ordinary polynomial functions, and analytical orthogonal blocking were developed and discussed. The resulting models comprise a set of smooth, differentiable functions for the non-dimensional aerodynamic force and moment coefficients in terms of ordinary polynomials in the independent variables, suitable for nonlinear aircraft simulation.

Spacewire router IP-core with priority adaptive routing

NASA Astrophysics Data System (ADS)

Shakhmatov, A. V.; Chekmarev, S. A.; Vergasov, M. Y.; Khanov, V. Kh

2015-10-01

Design of modern spacecraft focuses on using network principles of interaction on-board equipment, in particular in network SpaceWire. Routers are an integral part of most SpaceWire networks. The paper presents an adaptive routing algorithm with a prioritization, allowing more flexibility to manage the routing process. This algorithm is designed to transmit SpaceWire packets over a redundant network. Also a method is proposed for rapid restoration of working capacity after power by saving the routing table and the router configuration in an external non-volatile memory. The proposed solutions used to create IP-core router, and then tested in the FPGA device. The results illustrate the realizability and rationality of the proposed solutions.

Plasma radome designed for the EMP effects defense

NASA Astrophysics Data System (ADS)

Li, Zhigang; Wang, Jiachun; Cheng, Li; Wang, Qichao

2016-11-01

Radar, as the main detection means, plays an extremely important role in modern warfare. However, it is easily attacked by the electromagnetic pulse (EMP) weapon. In order to defense the threat, a radome formed by plasma is designed. The plasma radome is used to protect the radar systems against EMP coupling through both `front door' and `back door'. What's more, the damage effects of EMP to the radar systems are analyzed, and the protection mechanism of plasma to EMP weapon is discussed. In addition, a simulation experiment is carried out to verify the feasibility of the plasma radome to defense against EMP. The results indicate that the structure performs well, which makes it a new method against EMP weapon.

Propagation of Computational Uncertainty Using the Modern Design of Experiments

NASA Technical Reports Server (NTRS)

DeLoach, Richard

2007-01-01

This paper describes the use of formally designed experiments to aid in the error analysis of a computational experiment. A method is described by which the underlying code is approximated with relatively low-order polynomial graduating functions represented by truncated Taylor series approximations to the true underlying response function. A resource-minimal approach is outlined by which such graduating functions can be estimated from a minimum number of case runs of the underlying computational code. Certain practical considerations are discussed, including ways and means of coping with high-order response functions. The distributional properties of prediction residuals are presented and discussed. A practical method is presented for quantifying that component of the prediction uncertainty of a computational code that can be attributed to imperfect knowledge of independent variable levels. This method is illustrated with a recent assessment of uncertainty in computational estimates of Space Shuttle thermal and structural reentry loads attributable to ice and foam debris impact on ascent.

Use of personalized Dynamic Treatment Regimes (DTRs) and Sequential Multiple Assignment Randomized Trials (SMARTs) in mental health studies

PubMed Central

Liu, Ying; ZENG, Donglin; WANG, Yuanjia

2014-01-01

Summary Dynamic treatment regimens (DTRs) are sequential decision rules tailored at each point where a clinical decision is made based on each patient’s time-varying characteristics and intermediate outcomes observed at earlier points in time. The complexity, patient heterogeneity, and chronicity of mental disorders call for learning optimal DTRs to dynamically adapt treatment to an individual’s response over time. The Sequential Multiple Assignment Randomized Trial (SMARTs) design allows for estimating causal effects of DTRs. Modern statistical tools have been developed to optimize DTRs based on personalized variables and intermediate outcomes using rich data collected from SMARTs; these statistical methods can also be used to recommend tailoring variables for designing future SMART studies. This paper introduces DTRs and SMARTs using two examples in mental health studies, discusses two machine learning methods for estimating optimal DTR from SMARTs data, and demonstrates the performance of the statistical methods using simulated data. PMID:25642116

Wind tunnel technology for the development of future commercial aircraft

NASA Technical Reports Server (NTRS)

Szodruch, J.

1986-01-01

Requirements for new technologies in the area of civil aircraft design are mainly related to the high cost involved in the purchase of modern, fuel saving aircraft. A second important factor is the long term rise in the price of fuel. The demonstration of the benefits of new technologies, as far as these are related to aerodynamics, will,for the foreseeable future, still be based on wind tunnel measurements. Theoretical computation methods are very successfully used in design work, wing optimization, and an estimation of the Reynolds number effect. However, wind tunnel tests are still needed to verify the feasibility of the considered concepts. Along with other costs, the cost for the wind tunnel tests needed for the development of an aircraft is steadily increasing. The present investigation is concerned with the effect of numerical aerodynamics and civil aircraft technology on the development of wind tunnels. Attention is given to the requirements for the wind tunnel, investigative methods, measurement technology, models, and the relation between wind tunnel experiments and theoretical methods.

[Perspective and application of metabonomics in modern study of traditional Chinese medicine].

PubMed

Qin, Kun-Ming; Wang, Bin; Chen, Lin-Wei; Zhang, Mao-Sen; Yang, Guang-Ming; Shu, Ya-Chun; Cai, Bao-Chang

2014-08-01

Metabonomics is a new method to study on the metabolic network and the relationship between body and environment, which conforms to the way of traditional Chinese medicine (TCM) research. In the study process of modernization of traditional Chinese medicine, effectively conjunction with metabonomics method will facilitate the integration of TCM with modern biological science and technology, and promote the modernization of TCM. This paper introduce the application of metabonomics in the research of toxicity mechanism of TCM, compatibility mechanism of TCM formula, pharmacology effect of TCM and processing mechanism of TCM. This paper summarize the problems in the TCM metabonomics research and prospect its bright future.

Five Indisputable Facts on Modern Power Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bloom, Aaron P; Brinkman, Gregory L; Lopez, Anthony J

This presentation overviews five indisputable facts about modern power systems: Fact one: The grid can handle more renewable generation than previously thought. Fact two: Geographic and resource diversity provide additional reliability to the system. Fact three: Wind and solar forecasting provide significant value. Fact four: Our electric power markets were not originally designed for variable renewables -- but they could be adapted. Fact five: Modern power electronics are creating new sources of essential reliability services.

Trend in the use of modern contraception in sub-Saharan Africa: Does women's education matter?

PubMed

Emina, Jacques B O; Chirwa, Tobias; Kandala, Ngianga-Bakwin

2014-08-01

Existing literature revealed positive association between women's education and modern contraceptive use in sub-Saharan Africa (SSA). Overall modern contraception prevalence (MCP) and proportion of women with formal education have increased in region. However, little is known about how much the change in the prevalence of modern contraceptive methods is relative to the compositional change in population and how much of the change is actually due to increases in the number of women adopting the new behavior. This study aims to (1) describe trends in modern contraception prevalence by female education; and (2) identify the source of changes in modern contraceptive use by educational attainment (changes in structure or in population behavior). This is a cross-sectional study using Demographic and Health Surveys from 27 SSA countries where at least two comparable surveys have been conducted. Overall modern contraception prevalence (MCP) has increased in SSA over the study period. The ongoing increase in the contraceptive use is due to changes in behavior consistent with the ongoing family planning promotion over the past 30 years. By contrast, an increase in the proportion of women with secondary education does not explain the change in MCP in most SSA countries. To achieve universal access to family planning, efforts in promoting female education should be complemented with economic, cultural and geographical access to MCP. Household-based sensitization, general hospitals, mobile family planning clinics, and community-based distributors of modern contraceptive methods are key strategies to improve access to modern contraceptive use. Findings from this study suggest that countries should combine social investments, including health services and education, with family planning programs using reproductive health services, mobile family planning clinics and community-based distributors of modern contraceptive methods. Therefore, governments' legislation measures that promote universal secondary education as well as universal access to modern contraception can be put in place. Copyright © 2014 Elsevier Inc. All rights reserved.

A century of enzyme kinetic analysis, 1913 to 2013.

PubMed

Johnson, Kenneth A

2013-09-02

This review traces the history and logical progression of methods for quantitative analysis of enzyme kinetics from the 1913 Michaelis and Menten paper to the application of modern computational methods today. Following a brief review of methods for fitting steady state kinetic data, modern methods are highlighted for fitting full progress curve kinetics based upon numerical integration of rate equations, including a re-analysis of the original Michaelis-Menten full time course kinetic data. Finally, several illustrations of modern transient state kinetic methods of analysis are shown which enable the elucidation of reactions occurring at the active sites of enzymes in order to relate structure and function. Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

7 CFR 1751.100 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... developed methods of telecommunications. Modernization Plan (State Telecommunications Modernization Plan). A... legislature, or a numeric majority of the RUS Borrowers within the State. When this part refers to the PUC as... circuit, it is not the major method of transmission as in radiotelephone. ...

Modern NMR Spectroscopy.

ERIC Educational Resources Information Center

Jelinski, Lynn W.

1984-01-01

Discusses direct chemical information that can be obtained from modern nuclear magnetic resonance (NMR) methods, concentrating on the types of problems that can be solved. Shows how selected methods provide information about polymers, bipolymers, biochemistry, small organic molecules, inorganic compounds, and compounds oriented in a magnetic…

Modern vs. Traditional.

ERIC Educational Resources Information Center

Zhenhui, Rao

1999-01-01

This article discusses traditional methods, such as the grammar-translation, and modern methods, the communicative approach, for teaching English-as-a-foreign-language in China. The relationship between linguistic accuracy and communicative competence, student-centered orientation, and the role of the teacher are highlighted. (Author/VWL)

The P1-RKDG method for two-dimensional Euler equations of gas dynamics

NASA Technical Reports Server (NTRS)

Cockburn, Bernardo; Shu, Chi-Wang

1991-01-01

A class of nonlinearly stable Runge-Kutta local projection discontinuous Galerkin (RKDG) finite element methods for conservation laws is investigated. Two dimensional Euler equations for gas dynamics are solved using P1 elements. The generalization of the local projections, which for scalar nonlinear conservation laws was designed to satisfy a local maximum principle, to systems of conservation laws such as the Euler equations of gas dynamics using local characteristic decompositions is discussed. Numerical examples include the standard regular shock reflection problem, the forward facing step problem, and the double Mach reflection problem. These preliminary numerical examples are chosen to show the capacity of the approach to obtain nonlinearly stable results comparable with the modern nonoscillatory finite difference methods.

Barriers to modern contraceptive use in rural areas in DRC.

PubMed

Muanda, Mbadu Fidèle; Ndongo, Gahungu Parfait; Messina, Lauren J; Bertrand, Jane T

2017-09-01

Recent research in the Democratic Republic of Congo (DRC) has shown that over a quarter of women have an unmet need for family planning and that modern contraceptive use is three times higher among urban than rural women. This study focuses on the reasons behind the choices of married men and women to use contraception or not. What are the barriers that have led to low levels of modern contraceptive use among women and men in DRC rural areas? The research team conducted 24 focus groups among women (non-users of any method, users of traditional methods and users of modern methods) and husbands (of non-users or users of traditional methods) in six health zones of three geographically dispersed provinces. The key barriers that emerged were poor spousal communication, sociocultural norms (especially the husband's role as primary decision-maker and the desire for a large family), fear of side-effects and a lack of knowledge. Despite these barriers, many women in the study indicated that they were open to adopting a modern family planning method in the future. These findings imply that programming must address mutual comprehension and decision-making among rural men and women alike in order to trigger positive changes in behaviour and perceptions relating to contraceptive use.

[New trends in tonometry].

PubMed

Draeger, J A; Schwenteck, T; Ruokonen, P C

2006-10-01

Though the knowledge about the risk of elevated intraocular pressure for pathogenesis for development and progress of glaucoma is more than 400 years old. It took another 300 years before by means of tonometry this elevation could be quantified. After discussion of the key words it is our aim to demonstrate the latest trends in tonometry, specifically by use of modern electronics for instrument design. Goldmann was the founder of the "applanation tonometry", measuring the corelation of applanated area and applied force. Here, the next step was the development of instruments, measuring independent of position or gravity to allow application also at the lying patient. Electronic area detection was the next step to avoid examinor's error. Also important was the introduction of automatic UV-desinfection to avoid contamination of the other eye or other patients. Other tonometers control the force applied by an inductive method, which also allows application independent of position. Airpuff-tonometry uses completely different measuring principles - the resulting change of corneal curvature indicates the intraocular pressure. The impedance principle is applied even through the closed eye lid. The shock waves resulting shall be measured. Direct application of a surface sensor incorporated into a concave surface contact body shall allow direct measurement of intraocular pressure independent of corneal thickness, curvature, astigmatism. This method has been tried for more than 20 years. Also exposition of the eye to count waves of different frequency was an early attempt. Here also change of reflectivity is used to calculate intraocular pressure. Even after use of modern electronic technology the precision of many of these new devices does not lead to better results. This specifically is shown by modern calibration methods.

Advanced Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) Technical Exchange Meeting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Curtis

2013-09-01

During FY13, the INL developed an advanced SMR PRA framework which has been described in the report Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) Detailed Technical Framework Specification, INL/EXT-13-28974 (April 2013). In this framework, the various areas are considered: Probabilistic models to provide information specific to advanced SMRs Representation of specific SMR design issues such as having co-located modules and passive safety features Use of modern open-source and readily available analysis methods Internal and external events resulting in impacts to safety All-hazards considerations Methods to support the identification of design vulnerabilities Mechanistic and probabilistic data needs to support modelingmore » and tools In order to describe this framework more fully and obtain feedback on the proposed approaches, the INL hosted a technical exchange meeting during August 2013. This report describes the outcomes of that meeting.« less

Ergonomic Aspects of Transport of Patient through the Operating Theatre

NASA Astrophysics Data System (ADS)

Janowicz, Rafał

2017-10-01

One of the most crucial decisions to be made while designing and re-modernizing an operating theatre is selecting a method of transporting the patient through the hospital’s spatial arrangement. This decision, while irrelevant at first thought, implies numerous project and functional consequences. Designing an operating theatre within a hospital is related to numerous specialist requirements with an aim of minimizing the risk of microbiological contamination. Surgeries conducted on the operating theatre take place within sterile areas, usually within a protection area provided with laminar air flow. Furthermore, currently in Poland, there are applicable rules requiring to have entrances secured with tract locks leading towards the operational rooms for hospital personnel, patients as well as hospital equipment and materials. Such construction of an operating theatre provides the necessity of applying detailed procedures of transporting the patient, who in most cases is not able to reach the surgery on his or her own. In operating theatres functioning during the last decades, the operating tables were most often fixed to the floor. This resulted in the need to relocate the patient, who is ready for surgery, for several times. The consequences of this included risks related shock due to the relocations for the patient as well as physical overload for the medical staff. The aim of hereby article is to present modern designer solutions providing the opportunity to enhance ergonomics of using the operating theatre.

Efficient high-throughput biological process characterization: Definitive screening design with the ambr250 bioreactor system.

PubMed

Tai, Mitchell; Ly, Amanda; Leung, Inne; Nayar, Gautam

2015-01-01

The burgeoning pipeline for new biologic drugs has increased the need for high-throughput process characterization to efficiently use process development resources. Breakthroughs in highly automated and parallelized upstream process development have led to technologies such as the 250-mL automated mini bioreactor (ambr250™) system. Furthermore, developments in modern design of experiments (DoE) have promoted the use of definitive screening design (DSD) as an efficient method to combine factor screening and characterization. Here we utilize the 24-bioreactor ambr250™ system with 10-factor DSD to demonstrate a systematic experimental workflow to efficiently characterize an Escherichia coli (E. coli) fermentation process for recombinant protein production. The generated process model is further validated by laboratory-scale experiments and shows how the strategy is useful for quality by design (QbD) approaches to control strategies for late-stage characterization. © 2015 American Institute of Chemical Engineers.

The influence of surface finishing methods on touch-sensitive reactions

NASA Astrophysics Data System (ADS)

Kukhta, M. S.; Sokolov, A. P.; Krauinsh, P. Y.; Kozlova, A. D.; Bouchard, C.

2017-02-01

This paper describes the modern technological development trends in jewelry design. In the jewelry industry, new trends, associated with the introduction of updated non-traditional materials and finishing techniques, are appearing. The existing information-oriented society enhances the visual aesthetics of new jewelry forms, decoration techniques (depth and surface), synthesis of different materials, which, all in all, reveal a bias towards positive effects of visual design. Today, the jewelry industry includes not only traditional techniques, but also such improved techniques as computer-assisted design, 3D-prototyping and other alternatives to produce an updated level of jewelry material processing. The authors present the specific features of ornamental pattern designing, decoration types (depth and surface) and comparative analysis of different approaches in surface finishing. Identifying the appearance or the effect of jewelry is based on proposed evaluation criteria, providing an advanced visual aesthetics basis is predicated on touch-sensitive responses.

Aerodynamic optimization of supersonic compressor cascade using differential evolution on GPU

NASA Astrophysics Data System (ADS)

Aissa, Mohamed Hasanine; Verstraete, Tom; Vuik, Cornelis

2016-06-01

Differential Evolution (DE) is a powerful stochastic optimization method. Compared to gradient-based algorithms, DE is able to avoid local minima but requires at the same time more function evaluations. In turbomachinery applications, function evaluations are performed with time-consuming CFD simulation, which results in a long, non affordable, design cycle. Modern High Performance Computing systems, especially Graphic Processing Units (GPUs), are able to alleviate this inconvenience by accelerating the design evaluation itself. In this work we present a validated CFD Solver running on GPUs, able to accelerate the design evaluation and thus the entire design process. An achieved speedup of 20x to 30x enabled the DE algorithm to run on a high-end computer instead of a costly large cluster. The GPU-enhanced DE was used to optimize the aerodynamics of a supersonic compressor cascade, achieving an aerodynamic loss minimization of 20%.

An evaluation of 1D loss model collections for the off-design performance prediction of automotive turbocharger compressors

NASA Astrophysics Data System (ADS)

Harley, P.; Spence, S.; Early, J.; Filsinger, D.; Dietrich, M.

2013-12-01

Single-zone modelling is used to assess different collections of impeller 1D loss models. Three collections of loss models have been identified in literature, and the background to each of these collections is discussed. Each collection is evaluated using three modern automotive turbocharger style centrifugal compressors; comparisons of performance for each of the collections are made. An empirical data set taken from standard hot gas stand tests for each turbocharger is used as a baseline for comparison. Compressor range is predicted in this study; impeller diffusion ratio is shown to be a useful method of predicting compressor surge in 1D, and choke is predicted using basic compressible flow theory. The compressor designer can use this as a guide to identify the most compatible collection of losses for turbocharger compressor design applications. The analysis indicates the most appropriate collection for the design of automotive turbocharger centrifugal compressors.

RELAP-7 Software Verification and Validation Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Curtis L.; Choi, Yong-Joon; Zou, Ling

This INL plan comprehensively describes the software for RELAP-7 and documents the software, interface, and software design requirements for the application. The plan also describes the testing-based software verification and validation (SV&V) process—a set of specially designed software models used to test RELAP-7. The RELAP-7 (Reactor Excursion and Leak Analysis Program) code is a nuclear reactor system safety analysis code being developed at Idaho National Laboratory (INL). The code is based on the INL’s modern scientific software development framework – MOOSE (Multi-Physics Object-Oriented Simulation Environment). The overall design goal of RELAP-7 is to take advantage of the previous thirty yearsmore » of advancements in computer architecture, software design, numerical integration methods, and physical models. The end result will be a reactor systems analysis capability that retains and improves upon RELAP5’s capability and extends the analysis capability for all reactor system simulation scenarios.« less

Aerodynamic optimization of supersonic compressor cascade using differential evolution on GPU

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aissa, Mohamed Hasanine; Verstraete, Tom; Vuik, Cornelis

Differential Evolution (DE) is a powerful stochastic optimization method. Compared to gradient-based algorithms, DE is able to avoid local minima but requires at the same time more function evaluations. In turbomachinery applications, function evaluations are performed with time-consuming CFD simulation, which results in a long, non affordable, design cycle. Modern High Performance Computing systems, especially Graphic Processing Units (GPUs), are able to alleviate this inconvenience by accelerating the design evaluation itself. In this work we present a validated CFD Solver running on GPUs, able to accelerate the design evaluation and thus the entire design process. An achieved speedup of 20xmore » to 30x enabled the DE algorithm to run on a high-end computer instead of a costly large cluster. The GPU-enhanced DE was used to optimize the aerodynamics of a supersonic compressor cascade, achieving an aerodynamic loss minimization of 20%.« less

Nonlinear Aerodynamics and the Design of Wing Tips

NASA Technical Reports Server (NTRS)

Kroo, Ilan

1991-01-01

The analysis and design of wing tips for fixed wing and rotary wing aircraft still remains part art, part science. Although the design of airfoil sections and basic planform geometry is well developed, the tip regions require more detailed consideration. This is important because of the strong impact of wing tip flow on wing drag; although the tip region constitutes a small portion of the wing, its effect on the drag can be significant. The induced drag of a wing is, for a given lift and speed, inversely proportional to the square of the wing span. Concepts are proposed as a means of reducing drag. Modern computational methods provide a tool for studying these issues in greater detail. The purpose of the current research program is to improve the understanding of the fundamental issues involved in the design of wing tips and to develop the range of computational and experimental tools needed for further study of these ideas.

Analysis of Required Supporting Systems for the Supercritical CO(2) Power Conversion System

DTIC Science & Technology

2007-09-01

been drawn to the viability of using S-C02 as a working fluid in modern reactor designs. Near the critical point, C02 has a rapid rise in density...viability of using S-CO2 as a working fluid in modern reactor designs. Near the critical point, CO2 has a rapid rise in density allowing a significant...32 Figure 2.2.3 Effect on Mass Transferred of Changing ICV Initial Temperature for emptying PCS ...................32 Figure 2.2.4 Effect

Implementation and Evaluation of Flipped Classroom as IoT Element into Learning Process of Computer Network Education

ERIC Educational Resources Information Center

Zhamanov, Azamat; Yoo, Seong-Moo; Sakhiyeva, Zhulduz; Zhaparov, Meirambek

2018-01-01

Students nowadays are hard to be motivated to study lessons with traditional teaching methods. Computers, smartphones, tablets and other smart devices disturb students' attentions. Nevertheless, those smart devices can be used as auxiliary tools of modern teaching methods. In this article, the authors review two popular modern teaching methods:…

Requirements controlled design: A method for discovery of discontinuous system boundaries in the requirements hyperspace

NASA Astrophysics Data System (ADS)

Hollingsworth, Peter Michael

The drive toward robust systems design, especially with respect to system affordability throughout the system life-cycle, has led to the development of several advanced design methods. While these methods have been extremely successful in satisfying the needs for which they have been developed, they inherently leave a critical area unaddressed. None of them fully considers the effect of requirements on the selection of solution systems. The goal of all of current modern design methodologies is to bring knowledge forward in the design process to the regions where more design freedom is available and design changes cost less. Therefore, it seems reasonable to consider the point in the design process where the greatest restrictions are placed on the final design, the point in which the system level requirements are set. Historically the requirements have been treated as something handed down from above. However, neither the customer nor the solution provider completely understood all of the options that are available in the broader requirements space. If a method were developed that provided the ability to understand the full scope of the requirements space, it would allow for a better comparison of potential solution systems with respect to both the current and potential future requirements. The key to a requirements conscious method is to treat requirements differently from the traditional approach. The method proposed herein is known as Requirements Controlled Design (RCD). By treating the requirements as a set of variables that control the behavior of the system, instead of variables that only define the response of the system, it is possible to determine a-priori what portions of the requirements space that any given system is capable of satisfying. Additionally, it should be possible to identify which systems can satisfy a given set of requirements and the locations where a small change in one or more requirements poses a significant risk to a design program. This thesis puts forth the theory and methodology to enable RCD, and details and validates a specific method called the Modified Strength Pareto Evolutionary Algorithm (MSPEA).

The Role of Formal Experiment Design in Hypersonic Flight System Technology Development

NASA Technical Reports Server (NTRS)

McClinton, Charles R.; Ferlemann, Shelly M.; Rock, Ken E.; Ferlemann, Paul G.

2002-01-01

Hypersonic airbreathing engine (scramjet) powered vehicles are being considered to replace conventional rocket-powered launch systems. Effective utilization of scramjet engines requires careful integration with the air vehicle. This integration synergistically combines aerodynamic forces with propulsive cycle functions of the engine. Due to the highly integrated nature of the hypersonic vehicle design problem, the large flight envelope, and the large number of design variables, the use of a statistical design approach in design is effective. Modern Design-of-Experiments (MDOE) has been used throughout the Hyper-X program, for both systems analysis and experimental testing. Application of MDOE fall into four categories: (1) experimental testing; (2) studies of unit phenomena; (3) refining engine design; and (4) full vehicle system optimization. The MDOE process also provides analytical models, which are also used to document lessons learned, supplement low-level design tools, and accelerate future studies. This paper will discuss the design considerations for scramjet-powered vehicles, specifics of MDOE utilized for Hyper-X, and present highlights from the use of these MDOE methods within the Hyper-X Program.

Developing Baby Bag Design by Using Kansei Engineering Method

NASA Astrophysics Data System (ADS)

Janari, D.; Rakhmawati, A.

2016-01-01

Consumer's preferences and market demand are essential factors for product's success. Thus, in achieving its success, a product should have design that could fulfill consumer's expectation. Purpose of this research is accomplishing baby bag product as stipulated by Kansei. The results that represent Kanseiwords are; neat, unique, comfortable, safe, modern, gentle, elegant, antique, attractive, simple, spacious, creative, colorful, durable, stylish, smooth and strong. Identification value on significance of correlation for durable attribute is 0,000 < 0,005, which means significant to baby's bag. While the value of coefficient regression is 0,812 < 0,005, which means that durable attribute insignificant to baby's bag.The result of the baby's bag final design selectionbased on the questionnaire 3 is resulting the combination of all design. Space for clothes, diaper's space, shoulder grip, side grip, bottle's heater pocket and bottle's pocket are derived from design 1. Top grip, space for clothes, shoulder grip, and side grip are derived from design 2.Others design that were taken are, spaces for clothes from design 3, diaper's space and clothes’ space from design 4.

Optimal design of high-rise buildings with respect to fundamental eigenfrequency

NASA Astrophysics Data System (ADS)

Alavi, Arsalan; Rahgozar, Reza; Torkzadeh, Peyman; Hajabasi, Mohamad Ali

2017-12-01

In modern tall and slender structures, dynamic responses are usually the dominant design requirements, instead of strength criteria. Resonance is often a threatening phenomenon for such structures. To avoid this problem, the fundamental eigenfrequency, an eigenfrequency of higher order, should be maximized. An optimization problem with this objective is constructed in this paper and is applied to a high-rise building. Using variational method, the objective function is maximized, contributing to a particular profile for the first mode shape. Based on this preselected profile, a parametric formulation for flexural stiffness is calculated. Due to some near-zero values for stiffness, the obtained formulation will be modified by adding a lower bound constraint. To handle this constraint some new parameters are introduced; thereby allowing for construction of a model relating the unknown parameters. Based on this mathematical model, a design algorithmic procedure is presented. For the sake of convenience, a single-input design graph is presented as well. The main merit of the proposed method, compared to previous researches, is its hand calculation aspect, suitable for parametric studies and sensitivity analysis. As the presented formulations are dimensionless, they are applicable in any dimensional system. Accuracy and practicality of the proposed method is illustrated at the end by applying it to a real-life structure.

Use of traditional and modern contraceptives among childbearing women: findings from a mixed methods study in two southwestern Nigerian states.

PubMed

Ajayi, Anthony Idowu; Adeniyi, Oladele Vincent; Akpan, Wilson

2018-05-09

Contraceptive use has numerous health benefits such as preventing unplanned pregnancies, ensuring optimum spacing between births, reducing maternal and child mortality, and improving the lives of women and children in general. This study examines the level of contraceptive use, its determinants, reasons for non-use of contraception among women in the reproductive age group (18-49 years) in two southwestern Nigerian states. The study adopted an interviewer-administered questionnaire to collect data from 809 participants selected using a 3-stage cluster random sampling technique. We also conducted 46 in-depth interviews. In order to investigate the association between the socio-demographic variables and use of contraceptive methods, we estimated the binary logistic regression models. The findings indicated that knowledge of any methods of contraception was almost universal among the participants. The rates of ever use and current use of contraception was 80 and 66.6%, respectively. However, only 43.9% of the participants had ever used any modern contraceptive methods, considered to be more reliable. The fear of side effects of modern contraceptive methods drove women to rely on less effective traditional methods (withdrawal and rhythm methods). Some women employed crude and unproven contraceptive methods to prevent pregnancies. Our findings show that the rate of contraceptive use was high in the study setting. However, many women chose less effective traditional contraceptive methods over more effective modern contraceptive methods due to fear of side effects of the latter. Patient education on the various options of modern contraceptives, their side effects and management would be crucial towards expanding the family planning services in the study setting.

7 CFR 1751.104 - Obtaining RUS approval of a proposed Modernization Plan.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Obtaining RUS approval of a proposed Modernization Plan. 1751.104 Section 1751.104 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS SYSTEM PLANNING AND DESIGN...

Evidence from cluster surveys on the association between home-based counseling and use of family planning in conflict-affected Darfur.

PubMed

Adam, Izzeldin F

2016-05-01

To examine the association between home counseling and awareness and use of modern family planning (FP) methods among women in internally displaced person (IDP) camps in conflict-affected West Darfur, Sudan. In a community-based cross-sectional study, two questionnaire-based surveys were performed in three camps. Home-based counseling had been introduced in March 2006. An initial survey (February 2007) and a follow-up survey (April 2009) targeted women of child-bearing age. A sample of 640 randomly selected women aged 15-49 years who had experienced pregnancy after joining the camp were interviewed for each survey. Overall, modern FP use increased from 10.9% (70/640) in 2007 to 21.6% (138/640) in 2009 (P<0.001). As compared with the initial survey, women in the follow-up survey were more likely to be aware of and to use any modern FP method (adjusted odds ratio [aOR] 5.4, 95% confidence interval [CI] 3.9-7.4; and aOR 2.8, 95% CI 2.0-4.1, respectively). Contraceptive pills were the most common modern method used. Home counseling and loss of a child under 5years were the most significant predictors of awareness and use of modern FP methods. After the introduction of home-based FP counseling for couples and FP services in clinics, women's awareness and use of modern FP methods increased in a conflict-affected setting. Copyright © 2016 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

Analytical investigation of aerodynamic characteristics of highly swept wings with separated flow

NASA Technical Reports Server (NTRS)

Reddy, C. S.

1980-01-01

Many modern aircraft designed for supersonic speeds employ highly swept-back and low-aspect-ratio wings with sharp or thin edges. Flow separation occurs near the leading and tip edges of such wings at moderate to high angles of attack. Attempts have been made over the years to develop analytical methods for predicting the aerodynamic characteristics of such aircraft. Before any method can really be useful, it must be tested against a standard set of data to determine its capabilities and limitations. The present work undertakes such an investigation. Three methods are considered: the free-vortex-sheet method (Weber et al., 1975), the vortex-lattice method with suction analogy (Lamar and Gloss, 1975), and the quasi-vortex lattice method of Mehrotra (1977). Both flat and cambered wings of different configurations, for which experimental data are available, are studied and comparisons made.

Sparse QSAR modelling methods for therapeutic and regenerative medicine

NASA Astrophysics Data System (ADS)

Winkler, David A.

2018-02-01

The quantitative structure-activity relationships method was popularized by Hansch and Fujita over 50 years ago. The usefulness of the method for drug design and development has been shown in the intervening years. As it was developed initially to elucidate which molecular properties modulated the relative potency of putative agrochemicals, and at a time when computing resources were scarce, there is much scope for applying modern mathematical methods to improve the QSAR method and to extending the general concept to the discovery and optimization of bioactive molecules and materials more broadly. I describe research over the past two decades where we have rebuilt the unit operations of the QSAR method using improved mathematical techniques, and have applied this valuable platform technology to new important areas of research and industry such as nanoscience, omics technologies, advanced materials, and regenerative medicine. This paper was presented as the 2017 ACS Herman Skolnik lecture.

Do knowledge and cultural perceptions of modern female contraceptives predict male involvement in Ayete, Nigeria?

PubMed

Sanusi, A; Akinyemi, Oluwaseun O; Onoviran, Oghemetega O

2014-12-01

Male involvement is crucial to female contraceptive use. This study examined how male knowledge and cultural perceptions of modern female contraceptives influence involvement in contraceptive use. A cross-sectional survey of 389 men from Ayete, Nigeria was used to regress a continuous male involvement score on demographic variables, knowledge of at least one method of modern female contraception and a scored male perception variable using Ordinary Least Squares regression. Controlling for perception, the knowledge of at least one method of modern female contraception was not significantly associated with a change in male involvement (p=0.264). Increasing positive perception was associated with higher male involvement scores (p=0.001). Higher educated males, those with a current desire to have children and males whose partners were currently using a method had greater male involvement scores (p<0.05). Policy and intervention efforts should be focused on changing cultural perceptions, in addition to providing in-depth knowledge of contraceptive methods.

Media Influence on Sexual Activity and Contraceptive Use: A Cross Sectional Survey among Young Women in Urban Nigeria.

PubMed

Bajoga, Ummulkhulthum A; Atagame, Ken L; Okigbo, Chinelo C

2015-09-01

This study assessed the relationship between recent exposure to family planning (FP) messages in the media (newspaper, radio, television, and mobile phones) and use of modern contraceptive methods among women aged 15-24 years living in six cities in Nigeria. Logistic regression models were used to predict recent media exposure to FP messages and its association with sexual experience and modern contraceptive method use. About 45% of our sample had ever had sex with only a quarter of them using a modern contraceptive method at the time of survey. Approximately 71% of our sample was exposed to FP messages in the media within the three months preceding the survey. The main sources of media exposure were mobile phones (48%), radio (37%), and television (29%). Controlling for relevant factors, recent media exposure to FP messages predicted both sexual experience and use of modern contraceptive methods, although there were city-level differences.

The Use Potential of Traditional Building Materials for the Realization of Structures by Modern Methods of Construction

NASA Astrophysics Data System (ADS)

Spišáková, Marcela; Mačková, Daniela

2015-11-01

The sustainable building has taken off in recent years with many investors looking for new and different methods of construction. The traditional building materials can be made out of natural materials, while others can help to lower energy costs of the occupant once built. Regardless of what the goal of the investor is, traditional building materials and their use is on the rise. The submitted paper provides an overview of natural building materials and possible modern building systems using these construction materials. Based on the questionnaire survey is defined the use potential of traditional building materials for the realization of the construction by methods of modern constructions and then are determined the drivers and barriers of traditional materials through using modern methods of construction. Considering the analysis of the achieved results, we can identify the gaps in the construction market in Slovakia and also to assess the perception of potential investors in the field of traditional building materials use, which is the purpose of submitted paper.

Parameter Optimization for Feature and Hit Generation in a General Unknown Screening Method-Proof of Concept Study Using a Design of Experiment Approach for a High Resolution Mass Spectrometry Procedure after Data Independent Acquisition.

PubMed

Elmiger, Marco P; Poetzsch, Michael; Steuer, Andrea E; Kraemer, Thomas

2018-03-06

High resolution mass spectrometry and modern data independent acquisition (DIA) methods enable the creation of general unknown screening (GUS) procedures. However, even when DIA is used, its potential is far from being exploited, because often, the untargeted acquisition is followed by a targeted search. Applying an actual GUS (including untargeted screening) produces an immense amount of data that must be dealt with. An optimization of the parameters regulating the feature detection and hit generation algorithms of the data processing software could significantly reduce the amount of unnecessary data and thereby the workload. Design of experiment (DoE) approaches allow a simultaneous optimization of multiple parameters. In a first step, parameters are evaluated (crucial or noncrucial). Second, crucial parameters are optimized. The aim in this study was to reduce the number of hits, without missing analytes. The obtained parameter settings from the optimization were compared to the standard settings by analyzing a test set of blood samples spiked with 22 relevant analytes as well as 62 authentic forensic cases. The optimization lead to a marked reduction of workload (12.3 to 1.1% and 3.8 to 1.1% hits for the test set and the authentic cases, respectively) while simultaneously increasing the identification rate (68.2 to 86.4% and 68.8 to 88.1%, respectively). This proof of concept study emphasizes the great potential of DoE approaches to master the data overload resulting from modern data independent acquisition methods used for general unknown screening procedures by optimizing software parameters.

[Analysis on the accuracy of simple selection method of Fengshi (GB 31)].

PubMed

Li, Zhixing; Zhang, Haihua; Li, Suhe

2015-12-01

To explore the accuracy of simple selection method of Fengshi (GB 31). Through the study of the ancient and modern data,the analysis and integration of the acupuncture books,the comparison of the locations of Fengshi (GB 31) by doctors from all dynasties and the integration of modern anatomia, the modern simple selection method of Fengshi (GB 31) is definite, which is the same as the traditional way. It is believed that the simple selec tion method is in accord with the human-oriented thought of TCM. Treatment by acupoints should be based on the emerging nature and the individual difference of patients. Also, it is proposed that Fengshi (GB 31) should be located through the integration between the simple method and body surface anatomical mark.

Reasons and correlates of contraceptive discontinuation in Kuwait.

PubMed

Shah, N M; Shah, M A; Chowdhury, R I; Menon, I

2007-09-01

(1) To examine the probability of discontinuation of various methods within 1, 2, and three years of use and the reasons for discontinuation; 2) to analyse the socio-demographic correlates of discontinuation. Data from a survey of Kuwaiti women in reproductive ages conducted in 1999 were used. Information on duration of use of modern and traditional methods, and reasons for discontinuation during the 72 months before the survey were analysed. Probabilities of discontinuation were estimated through multiple decrement life table analysis. After 1 year, 30% of modern and 40% of traditional method users had discontinued; after 3 years, discontinuation increased to 66 and 70%, respectively. After 36 months, only 40% of IUD users discontinued compared with 74% of oral contraceptive users. The desire to become pregnant was the leading reason for discontinuation of most modern methods, while method failure was an equally important reason for traditional methods. Discontinuation was significantly more frequent among higher parity, non-working and Bedouin women, and among those who said Islam disapproves of contraception. Contraception is used largely for spacing. More than two-thirds of the women studied had discontinued most methods after three years, except the IUD, which was used only by about 10% of them. Traditional methods are often discontinued due to method failure and may result in an unintended pregnancy. Better counselling is warranted for traditional methods. Health care for managing side effects of modern methods also needs improvement.

Application of modern tools and techniques to maximize engineering productivity in the development of orbital operations plans for the space station progrm

NASA Technical Reports Server (NTRS)

Manford, J. S.; Bennett, G. R.

1985-01-01

The Space Station Program will incorporate analysis of operations constraints and considerations in the early design phases to avoid the need for later modifications to the Space Station for operations. The application of modern tools and administrative techniques to minimize the cost of performing effective orbital operations planning and design analysis in the preliminary design phase of the Space Station Program is discussed. Tools and techniques discussed include: approach for rigorous analysis of operations functions, use of the resources of a large computer network, and providing for efficient research and access to information.

Preliminary Results on FeCrAl Alloys in the As-received and Welded State Designed to Have Enhanced Weldability and Radiation Tolerance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Field, Kevin G.; Gussev, Maxim N.; Hu, Xunxiang

2015-09-30

The present report summarizes and discusses the recent results on developing a modern, nuclear grade FeCrAl alloy designed to have enhanced radiation tolerance and weldability. The alloys used for these investigations are modern FeCrAl alloys based on a Fe-13Cr-5Al-2Mo-0.2Si-0.05Y alloy (in wt.%, designated C35M). Development efforts have focused on assessing the influence of chemistry and microstructure on the fabricability and performance of these newly developed alloys. Specific focus was made to assess the weldability, thermal stability, and radiation tolerance.

Green Infrastructure Design Based on Spatial Conservation Prioritization and Modeling of Biodiversity Features and Ecosystem Services.

PubMed

Snäll, Tord; Lehtomäki, Joona; Arponen, Anni; Elith, Jane; Moilanen, Atte

2016-02-01

There is high-level political support for the use of green infrastructure (GI) across Europe, to maintain viable populations and to provide ecosystem services (ES). Even though GI is inherently a spatial concept, the modern tools for spatial planning have not been recognized, such as in the recent European Environment Agency (EEA) report. We outline a toolbox of methods useful for GI design that explicitly accounts for biodiversity and ES. Data on species occurrence, habitats, and environmental variables are increasingly available via open-access internet platforms. Such data can be synthesized by statistical species distribution modeling, producing maps of biodiversity features. These, together with maps of ES, can form the basis for GI design. We argue that spatial conservation prioritization (SCP) methods are effective tools for GI design, as the overall SCP goal is cost-effective allocation of conservation efforts. Corridors are currently promoted by the EEA as the means for implementing GI design, but they typically target the needs of only a subset of the regional species pool. SCP methods would help to ensure that GI provides a balanced solution for the requirements of many biodiversity features (e.g., species, habitat types) and ES simultaneously in a cost-effective manner. Such tools are necessary to make GI into an operational concept for combating biodiversity loss and promoting ES.

Green Infrastructure Design Based on Spatial Conservation Prioritization and Modeling of Biodiversity Features and Ecosystem Services

NASA Astrophysics Data System (ADS)

Snäll, Tord; Lehtomäki, Joona; Arponen, Anni; Elith, Jane; Moilanen, Atte

2016-02-01

There is high-level political support for the use of green infrastructure (GI) across Europe, to maintain viable populations and to provide ecosystem services (ES). Even though GI is inherently a spatial concept, the modern tools for spatial planning have not been recognized, such as in the recent European Environment Agency (EEA) report. We outline a toolbox of methods useful for GI design that explicitly accounts for biodiversity and ES. Data on species occurrence, habitats, and environmental variables are increasingly available via open-access internet platforms. Such data can be synthesized by statistical species distribution modeling, producing maps of biodiversity features. These, together with maps of ES, can form the basis for GI design. We argue that spatial conservation prioritization (SCP) methods are effective tools for GI design, as the overall SCP goal is cost-effective allocation of conservation efforts. Corridors are currently promoted by the EEA as the means for implementing GI design, but they typically target the needs of only a subset of the regional species pool. SCP methods would help to ensure that GI provides a balanced solution for the requirements of many biodiversity features (e.g., species, habitat types) and ES simultaneously in a cost-effective manner. Such tools are necessary to make GI into an operational concept for combating biodiversity loss and promoting ES.

Feasibility study of modern airships, phase 1, volume 1. [structural design criteria/technology assessment

NASA Technical Reports Server (NTRS)

Joner, B.

1975-01-01

The history of the airship is examined from a technical and operational/mission point of view. The impact on a modern airship design by present technology is defined in some selected, representative areas through a comparison between 1930 and 1975 state-of-the-art. A survey of missions with a potential for the airship was made and some viable applications are established. Several concepts of modern airships were taken through a parametric design analysis in the missions previously established, evolving in a new configuration of a hybrid airship - the Helipsoid -, combining static lift and dynamic lift from tilting propeller/rotors and the planform. Cruise speeds in the 150-200 kt (77-103 m/s) will be possible with this configuration with reasonable engine power. The Helipsoid offers at the same time a realistic and practicable solution to the ballast problem, which is inherent in a vehicle generating its lift (fully or partially) from a medium lighter than air.

Socioeconomic factors associated with contraceptive use and method choice in urban slums of Bangladesh.

PubMed

Kamal, S M Mostafa

2015-03-01

This article explores the socioeconomic factors affecting contraceptive use and method choice among women of urban slums using the nationally representative 2006 Bangladesh Urban Health Survey. Both bivariate and multivariate statistical analyses were applied to examine the relationship between a set of sociodemographic factors and the dependent variables. Overall, the contraceptive prevalence rate was 58.1%, of which 53.2% were modern methods. Women's age, access to TV, number of unions, nongovernmental organization membership, working status of women, number of living children, child mortality, and wealth index were important determinants of contraceptive use and method preference. Sex composition of surviving children and women's education were the most important determinants of contraceptive use and method choice. Programs should be strengthened to provide nonclinical modern methods free of cost among the slum dwellers. Doorstep delivery services of modern contraceptive methods may raise the contraceptive prevalence rate among the slum dwellers in Bangladesh. © 2011 APJPH.

Application of high speed machining technology in aviation

NASA Astrophysics Data System (ADS)

Bałon, Paweł; Szostak, Janusz; Kiełbasa, Bartłomiej; Rejman, Edward; Smusz, Robert

2018-05-01

Aircraft structures are exposed to many loads during their working lifespan. Every particular action made during a flight is composed of a series of air movements which generate various aircraft loads. The most rigorous requirement which modern aircraft structures must fulfill is to maintain their high durability and reliability. This requirement involves taking many restrictions into account during the aircraft design process. The most important factor is the structure's overall mass, which has a crucial impact on both utility properties and cost-effectiveness. This makes aircraft one of the most complex results of modern technology. Additionally, there is currently an increasing utilization of high strength aluminum alloys, which requires the implementation of new manufacturing processes. High Speed Machining technology (HSM) is currently one of the most important machining technologies used in the aviation industry, especially in the machining of aluminium alloys. The primary difference between HSM and other milling techniques is the ability to select cutting parameters - depth of the cut layer, feed rate, and cutting speed in order to simultaneously ensure high quality, precision of the machined surface, and high machining efficiency, all of which shorten the manufacturing process of the integral components. In this paper, the authors explain the implementation of the HSM method in integral aircraft constructions. It presents the method of the airframe manufacturing method, and the final results. The HSM method is compared to the previous method where all subcomponents were manufactured by bending and forming processes, and then, they were joined by riveting.

National Transonic Facility Wall Pressure Calibration Using Modern Design of Experiments (Invited)

NASA Technical Reports Server (NTRS)

Underwood, Pamela J.; Everhart, Joel L.; DeLoach, Richard

2001-01-01

The Modern Design of Experiments (MDOE) has been applied to wind tunnel testing at NASA Langley Research Center for several years. At Langley, MDOE has proven to be a useful and robust approach to aerodynamic testing that yields significant reductions in the cost and duration of experiments while still providing for the highest quality research results. This paper extends its application to include empty tunnel wall pressure calibrations. These calibrations are performed in support of wall interference corrections. This paper will present the experimental objectives, and the theoretical design process. To validate the tunnel-empty-calibration experiment design, preliminary response surface models calculated from previously acquired data are also presented. Finally, lessons learned and future wall interference applications of MDOE are discussed.

Romanian traditional motif - element of modernity in clothing

NASA Astrophysics Data System (ADS)

Doble, L.; Stan, O.; Suteu, M. D.; Albu, A.; Bohm, G.; Tsatsarou-Michalaki, A.; Gialinou, E.

2017-10-01

In this paper are presented the phases for improving from an aesthetic point of view a clothing item, the jacket respectively, with a straight cut for women using software design patterns, computerised graphics and textile different modern technologies including: industrial embroidery, digital printing, sublimation. In the first phase a documentation was prepared in the Ethnographic Museum of Transylvania from Cluj Napoca where more traditional motifs were selected specific to Transylvania etnographic region and were reintepreted and stylized whilst preserving the symbolism and color range specified to the area. For the styling phase was used CorelDraw vector graphics program that allows changing the shape, size and color of the drawings without affecting the identity of the pattern. In the patterns design phase Gemini CAD software was used and for the modeling and model development Optitex software was used. The part for garnishing the model was performed using Embrodery machine software reproducing the stylized motif identically. In order to obtain a significantly improved aesthetic look and an added artistic value the pattern chosen for the jacket was done using a combination of modern textile technologies. This has allowed the realization of a particular texture on the surface of the designed product, demonstrating that traditional patterns can be reintepreted in modern clothing

Health-seeking behaviour for schistosomiasis: a systematic review of qualitative and quantitative literature.

PubMed

Cronin, Thomas; Sheppard, James; de Wildt, Gilles

2013-01-01

Schistosomiasis is a chronic and debilitating parasitic disease acquired through contact with infested freshwater. An essential component of its control is passive case finding, which, in order to be effective, requires a detailed understanding of health-seeking behaviour. This study aimed to systematically review evidence on health-seeking behaviour for schistosomiasis, in order to determine factors influencing use or non-use of modern health services for the infection. Quantitative, qualitative and mixed method studies reporting on factors related to seeking treatment from modern health services for schistosomiasis were obtained, combining electronic and hand searching. Data extraction and quality assessment of the included articles were performed, with all studies qualitatively analysed using thematic synthesis. A total of 19 studies were included in the review. Six themes were identified from the analysis: biomedical knowledge on schistosomiasis, perceptions of modern treatment and health services, financial considerations of treatment, perceptions on the symptoms, stigma of the infection, and physical location and community. These findings were consistent across studies of different design, setting and quality. Many of the themes identified echo existing literature on health-seeking behaviour. The synthesis also highlighted the role of stigma, and aspects of the physical location and community that may affect treatment-seeking for schistosomiasis. Health education programmes that intend to improve the utilisation of modern health services for the infection need to acknowledge the multiple determinants influencing their use. Future research should move beyond describing health-seeking behaviour to identifying the factors that underlay such behaviour.

Revealing Nucleic Acid Mutations Using Förster Resonance Energy Transfer-Based Probes

PubMed Central

Junager, Nina P. L.; Kongsted, Jacob; Astakhova, Kira

2016-01-01

Nucleic acid mutations are of tremendous importance in modern clinical work, biotechnology and in fundamental studies of nucleic acids. Therefore, rapid, cost-effective and reliable detection of mutations is an object of extensive research. Today, Förster resonance energy transfer (FRET) probes are among the most often used tools for the detection of nucleic acids and in particular, for the detection of mutations. However, multiple parameters must be taken into account in order to create efficient FRET probes that are sensitive to nucleic acid mutations. In this review; we focus on the design principles for such probes and available computational methods that allow for their rational design. Applications of advanced, rationally designed FRET probes range from new insights into cellular heterogeneity to gaining new knowledge of nucleic acid structures directly in living cells. PMID:27472344

Islamic Modernism and Architectural Modernism of Muhammadiyah’s Lio Mosque

NASA Astrophysics Data System (ADS)

Prajawisastra, A. F.; Aryanti, T.

2017-03-01

The Muhammadiyah’s Lio Mosque is one of the masterpieces of Achmad Noe’man, the great Indonesian mosque architect. The mosque was built as a community mosque at the center of Muhammadiyah’s quarter in Garut, West Java, in conjuction with the construction of the district’s Muhammadiyah branch. Having a shape out of the existing grip, the mosque has neither a dome nor a tajug tumpang tiga (three-tiered pyramidal roof) like other mosques nearby, but instead uses a gable roof and minarets towering. This article aims to analyze the architecture of the Lio Mosque and to learn Achmad Noe’man’s interpretation of modernism, both Islamic modernism and architectural modernism, reflected in the mosque design. Employing a qualitative approach, this study used observation and interviews with the mosque’s stakeholders. This article argues that the ideology of modernism, believed by Achmad Noe’man and the Muhammadiyah organization, was embodied in the Lio Mosque architecture.

Responsibility: A Thematic Sequence of English Units.

ERIC Educational Resources Information Center

Institute for Services to Education, Inc., Washington, DC.

One of a series of volumes containing units on specific themes designed for use in college freshman English courses, this particular volume considers people and their responsibilities, through the use of recordings, cartoons, satire, modern and ancient drama, modern fiction, and contemporary essays. The sequence is divided into four sections.…

Modern Psychometrics for Assessing Achievement Goal Orientation: A Rasch Analysis

ERIC Educational Resources Information Center

Muis, Krista R.; Winne, Philip H.; Edwards, Ordene V.

2009-01-01

Background: A program of research is needed that assesses the psychometric properties of instruments designed to quantify students' achievement goal orientations to clarify inconsistencies across previous studies and to provide a stronger basis for future research. Aim: We conducted traditional psychometric and modern Rasch-model analyses of the…

A quality by design approach using artificial intelligence techniques to control the critical quality attributes of ramipril tablets manufactured by wet granulation.

PubMed

Aksu, Buket; Paradkar, Anant; de Matas, Marcel; Özer, Özgen; Güneri, Tamer; York, Peter

2013-02-01

Quality by design (QbD) is an essential part of the modern approach to pharmaceutical quality. This study was conducted in the framework of a QbD project involving ramipril tablets. Preliminary work included identification of the critical quality attributes (CQAs) and critical process parameters (CPPs) based on the quality target product profiles (QTPPs) using the historical data and risk assessment method failure mode and effect analysis (FMEA). Compendial and in-house specifications were selected as QTPPs for ramipril tablets. CPPs that affected the product and process were used to establish an experimental design. The results thus obtained can be used to facilitate definition of the design space using tools such as design of experiments (DoE), the response surface method (RSM) and artificial neural networks (ANNs). The project was aimed at discovering hidden knowledge associated with the manufacture of ramipril tablets using a range of artificial intelligence-based software, with the intention of establishing a multi-dimensional design space that ensures consistent product quality. At the end of the study, a design space was developed based on the study data and specifications, and a new formulation was optimized. On the basis of this formulation, a new laboratory batch formulation was prepared and tested. It was confirmed that the explored formulation was within the design space.

[Watsu: a modern method in physiotherapy, body regeneration, and sports].

PubMed

Weber-Nowakowska, Katarzyna; Gebska, Magdalena; Zyzniewska-Banaszak, Ewelina

2013-01-01

Progress in existing methods of physiotherapy and body regeneration and introduction of new methods has made it possible to precisely select the techniques according to patient needs. The modern therapist is capable of improving the physical and mental condition of the patient. Watsu helps the therapist eliminate symptoms from the locomotor system and reach the psychic sphere at the same time.

Constraints on primary and secondary particulate carbon sources using chemical tracer and 14C methods during CalNex-Bakersfield

NASA Astrophysics Data System (ADS)

Sheesley, Rebecca J.; Nallathamby, Punith Dev; Surratt, Jason D.; Lee, Anita; Lewandowski, Michael; Offenberg, John H.; Jaoui, Mohammed; Kleindienst, Tadeusz E.

2017-10-01

The present study investigates primary and secondary sources of organic carbon for Bakersfield, CA, USA as part of the 2010 CalNex study. The method used here involves integrated sampling that is designed to allow for detailed and specific chemical analysis of particulate matter (PM) in the Bakersfield airshed. To achieve this objective, filter samples were taken during thirty-four 23-hr periods between 19 May and 26 June 2010 and analyzed for organic tracers by gas chromatography - mass spectrometry (GC-MS). Contributions to organic carbon (OC) were determined by two organic tracer-based techniques: primary OC by chemical mass balance and secondary OC by a mass fraction method. Radiocarbon (14C) measurements of the total organic carbon were also made to determine the split between the modern and fossil carbon and thereby constrain unknown sources of OC not accounted for by either tracer-based attribution technique. From the analysis, OC contributions from four primary sources and four secondary sources were determined, which comprised three sources of modern carbon and five sources of fossil carbon. The major primary sources of OC were from vegetative detritus (9.8%), diesel (2.3%), gasoline (<1.0%), and lubricating oil impacted motor vehicle exhaust (30%); measured secondary sources resulted from isoprene (1.5%), α-pinene (<1.0%), toluene (<1.0%), and naphthalene (<1.0%, as an upper limit) contributions. The average observed organic carbon (OC) was 6.42 ± 2.33 μgC m-3. The 14C derived apportionment indicated that modern and fossil components were nearly equivalent on average; however, the fossil contribution ranged from 32 to 66% over the five week campaign. With the fossil primary and secondary sources aggregated, only 25% of the fossil organic carbon could not be attributed. Whereas, nearly 80% of the modern carbon could not be attributed to primary and secondary sources accessible to this analysis, which included tracers of biomass burning, vegetative detritus and secondary biogenic carbon. The results of the current study contributes source-based evaluation of the carbonaceous aerosol at CalNex Bakersfield.

Constraints on primary and secondary particulate carbon sources using chemical tracer and 14C methods during CalNex-Bakersfield

PubMed Central

Sheesley, Rebecca J.; Nallathamby, Punith Dev; Surratt, Jason D.; Lee, Anita; Lewandowski, Michael; Offenberg, John H.; Jaoui, Mohammed; Kleindienst, Tadeusz E.

2018-01-01

The present study investigates primary and secondary sources of organic carbon for Bakersfield, CA, USA as part of the 2010 CalNex study. The method used here involves integrated sampling that is designed to allow for detailed and specific chemical analysis of particulate matter (PM) in the Bakersfield airshed. To achieve this objective, filter samples were taken during thirty-four 23-hr periods between 19 May and 26 June 2010 and analyzed for organic tracers by gas chromatography – mass spectrometry (GC-MS). Contributions to organic carbon (OC) were determined by two organic tracer-based techniques: primary OC by chemical mass balance and secondary OC by a mass fraction method. Radiocarbon (14C) measurements of the total organic carbon were also made to determine the split between the modern and fossil carbon and thereby constrain unknown sources of OC not accounted for by either tracer-based attribution technique. From the analysis, OC contributions from four primary sources and four secondary sources were determined, which comprised three sources of modern carbon and five sources of fossil carbon. The major primary sources of OC were from vegetative detritus (9.8%), diesel (2.3%), gasoline (<1.0%), and lubricating oil impacted motor vehicle exhaust (30%); measured secondary sources resulted from isoprene (1.5%), α-pinene (<1.0%), toluene (<1.0%), and naphthalene (<1.0%, as an upper limit) contributions. The average observed organic carbon (OC) was 6.42 ± 2.33 μgC m−3. The 14C derived apportionment indicated that modern and fossil components were nearly equivalent on average; however, the fossil contribution ranged from 32-66% over the five week campaign. With the fossil primary and secondary sources aggregated, only 25% of the fossil organic carbon could not be attributed. Whereas, nearly 80% of the modern carbon could not be attributed to primary and secondary sources accessible to this analysis, which included tracers of biomass burning, vegetative detritus and secondary biogenic carbon. The results of the current study contributes source-based evaluation of the carbonaceous aerosol at CalNex Bakersfield. PMID:29681757

Gearing

NASA Technical Reports Server (NTRS)

Coy, J. J.; Townsend, D. P.; Zaretsky, E. V.

1985-01-01

Gearing technology in its modern form has a history of only 100 years. However, the earliest form of gearing can probably be traced back to fourth century B.C. Greece. Current gear practice and recent advances in the technology are drawn together. The history of gearing is reviewed briefly in the Introduction. Subsequent sections describe types of gearing and their geometry, processing, and manufacture. Both conventional and more recent methods of determining gear stress and deflections are considered. The subjects of life prediction and lubrication are additions to the literature. New and more complete methods of power loss predictions as well as an optimum design of spur gear meshes are described. Conventional and new types of power transmission systems are presented.

Trinary Encoder, Decoder, Multiplexer and Demultiplexer Using Savart Plate and Spatial Light Modulator

NASA Astrophysics Data System (ADS)

Ghosh, Amal K.; Singha Roy, Souradip; Mandal, Sudipta; Basuray, Amitabha

Optoelectronic processors have already been developed with the strong potentiality of optics in information and data processing. Encoder, Decoder, Multiplexers and Demultiplexers are the most important components in modern system designs and in communications. We have implemented the same using trinary logic gates with signed magnitude defined as Modified Trinary Number (MTN). The Spatial Light Modulator (SLM) based optoelectronic circuit is suitable for high speed data processing and communications using photon as carrier. We also presented here a possible method of implementing the same using light with photon as carrier of information. The importance of the method is that all the basic gates needed may be fabricated based on basic building block.

Development of Scanning Ultrafast Electron Microscope Capability.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, Kimberlee Chiyoko; Talin, Albert Alec; Chandler, David W.

Modern semiconductor devices rely on the transport of minority charge carriers. Direct examination of minority carrier lifetimes in real devices with nanometer-scale features requires a measurement method with simultaneously high spatial and temporal resolutions. Achieving nanometer spatial resolutions at sub-nanosecond temporal resolution is possible with pump-probe methods that utilize electrons as probes. Recently, a stroboscopic scanning electron microscope was developed at Caltech, and used to study carrier transport across a Si p-n junction [ 1 , 2 , 3 ] . In this report, we detail our development of a prototype scanning ultrafast electron microscope system at Sandia National Laboratoriesmore » based on the original Caltech design. This effort represents Sandia's first exploration into ultrafast electron microscopy.« less

Run-Curve Design for Energy Saving Operation in a Modern DC-Electrification

NASA Astrophysics Data System (ADS)

Koseki, Takafumi; Noda, Takashi

Mechanical brakes are often used by electric trains. These brakes have a few problems like response speed, coefficient of friction, maintenance cost and so on. As a result, methods for actively using regenerative brakes are required. In this paper, we propose the useful pure electric braking, which would involve ordinary brakes by only regenerative brakes without any mechanical brakes at high speed. Benefits of our proposal include a DC-electrification system with regenerative substations that can return powers to the commercial power system and a train that can use the full regenerative braking force. We furthermore evaluate the effects on running time and energies saved by regenerative substations in the proposed method.

[Diagnosis and treatment of metabolic syndrome combined with liver toxicity genesis in contract service officers].

PubMed

Semiserin, V A; Khritinin, D F; Maev, I V; Karakozov, A T; Eremin, M N; Olenicheva, E L

2012-01-01

In this paper is synthesized current and recent data on the problem of metabolic syndrome (MS) in combination with toxic liver injury (CCI). Statistical parameters of the last 15 years, the dynamics of alimentary-constitutional obesity (ABC) in patients from the officers contracted service of Defense Ministry of Russia are reflected. Two-year experience in the application of modern non-invasive methods of diagnosis of liver fibrosis with a reflection of its dynamics on the background of complex treatment of patients with MS in conjunction with the Chamber on the example of 57 patients is shown. Paid great attention to psychological and emotional adjustment of patients with ABC, given the complex survey design and treatment in violation of motivational and behavioral responses. High clinical efficiency of combination drug therapy of MS and CCI, the diagnostic value of modern non-invasive methods of diagnosis of hepatic fibrosis are reliably performed. Technique of elastography significantly improves the liver clinical evaluation of the effectiveness of the therapy, allows for early detect the presence of the initial degree of hepatic fibrosis, choose the optimal treatment regimen and to evaluate the results dynamically.

Portable Raman monitoring of modern cleaning and consolidation operations of artworks on mineral supports.

PubMed

Martínez-Arkarazo, I; Sarmiento, A; Maguregui, M; Castro, K; Madariaga, J M

2010-08-01

Any restoration performed on cultural heritage artworks must guarantee a low impact on the treated surfaces. Although completely risk-free methods do not exist, the use of tailor-made procedures and the continuous monitoring by portable instrumentation is surely one of the best approaches to conduct a modern restoration process. In this work, a portable Raman monitoring, combined sometimes with spectroscopic techniques providing the elemental composition, is the key analysis technique in the three-step restoration protocol proposed: (a) in situ analysis of the surface to be treated (original composition and degradation products/pollutants) and the cleaning agents used as extractants, (b) the thermodynamic study of the species involved in the treatment in order to design a suitable restoration method and (c) application and monitoring of the treatment. Two cleaning operations based on new technologies were studied and applied to two artworks on mineral supports: a wall painting affected by nitrate impact, and a black crusted stone (chalk) altarpiece. Raman bands of nitrate and gypsum, respectively, decreased after the step-by-step operations in each case, which helped restorers to decide when the treatment was concluded, thus avoiding any further damage to the treated surface of the artworks.

Method and computer program product for maintenance and modernization backlogging

DOEpatents

Mattimore, Bernard G; Reynolds, Paul E; Farrell, Jill M

2013-02-19

According to one embodiment, a computer program product for determining future facility conditions includes a computer readable medium having computer readable program code stored therein. The computer readable program code includes computer readable program code for calculating a time period specific maintenance cost, for calculating a time period specific modernization factor, and for calculating a time period specific backlog factor. Future facility conditions equal the time period specific maintenance cost plus the time period specific modernization factor plus the time period specific backlog factor. In another embodiment, a computer-implemented method for calculating future facility conditions includes calculating a time period specific maintenance cost, calculating a time period specific modernization factor, and calculating a time period specific backlog factor. Future facility conditions equal the time period specific maintenance cost plus the time period specific modernization factor plus the time period specific backlog factor. Other embodiments are also presented.

Bayesian Inference in the Modern Design of Experiments

NASA Technical Reports Server (NTRS)

DeLoach, Richard

2008-01-01

This paper provides an elementary tutorial overview of Bayesian inference and its potential for application in aerospace experimentation in general and wind tunnel testing in particular. Bayes Theorem is reviewed and examples are provided to illustrate how it can be applied to objectively revise prior knowledge by incorporating insights subsequently obtained from additional observations, resulting in new (posterior) knowledge that combines information from both sources. A logical merger of Bayesian methods and certain aspects of Response Surface Modeling is explored. Specific applications to wind tunnel testing, computational code validation, and instrumentation calibration are discussed.

Porting of the transfer-matrix method for multilayer thin-film computations on graphics processing units

NASA Astrophysics Data System (ADS)

Limmer, Steffen; Fey, Dietmar

2013-07-01

Thin-film computations are often a time-consuming task during optical design. An efficient way to accelerate these computations with the help of graphics processing units (GPUs) is described. It turned out that significant speed-ups can be achieved. We investigate the circumstances under which the best speed-up values can be expected. Therefore we compare different GPUs among themselves and with a modern CPU. Furthermore, the effect of thickness modulation on the speed-up and the runtime behavior depending on the input data is examined.

Advanced materials for aircraft engine applications.

PubMed

Backman, D G; Williams, J C

1992-02-28

A review of advances for aircraft engine structural materials and processes is presented. Improved materials, such as superalloys, and the processes for making turbine disks and blades have had a major impact on the capability of modern gas turbine engines. New structural materials, notably composites and intermetallic materials, are emerging that will eventually further enhance engine performance, reduce engine weight, and thereby enable new aircraft systems. In the future, successful aerospace manufacturers will combine product design and materials excellence with improved manufacturing methods to increase production efficiency, enhance product quality, and decrease the engine development cycle time.

Advances in traction drive technology

NASA Technical Reports Server (NTRS)

Loewenthal, S. H.; Anderson, N. E.; Rohn, D. A.

1983-01-01

Traction drives are traced from early uses as main transmissions in automobiles at the turn of the century to modern, high-powered traction drives capable of transmitting hundreds of horsepower. Recent advances in technology are described which enable today's traction drive to be a serious candidate for off-highway vehicles and helicopter applications. Improvements in materials, traction fluids, design techniques, power loss and life prediction methods will be highlighted. Performance characteristics of the Nasvytis fixed-ratio drive are given. Promising future drive applications, such as helicopter main transmissions and servo-control positioning mechanisms are also addressed.

Minimum emittance in TBA and MBA lattices

NASA Astrophysics Data System (ADS)

Xu, Gang; Peng, Yue-Mei

2015-03-01

For reaching a small emittance in a modern light source, triple bend achromats (TBA), theoretical minimum emittance (TME) and even multiple bend achromats (MBA) have been considered. This paper derived the necessary condition for achieving minimum emittance in TBA and MBA theoretically, where the bending angle of inner dipoles has a factor of 31/3 bigger than that of the outer dipoles. Here, we also calculated the conditions attaining the minimum emittance of TBA related to phase advance in some special cases with a pure mathematics method. These results may give some directions on lattice design.

Assessment of CFD capability for prediction of hypersonic shock interactions

NASA Astrophysics Data System (ADS)

Knight, Doyle; Longo, José; Drikakis, Dimitris; Gaitonde, Datta; Lani, Andrea; Nompelis, Ioannis; Reimann, Bodo; Walpot, Louis

2012-01-01

The aerothermodynamic loadings associated with shock wave boundary layer interactions (shock interactions) must be carefully considered in the design of hypersonic air vehicles. The capability of Computational Fluid Dynamics (CFD) software to accurately predict hypersonic shock wave laminar boundary layer interactions is examined. A series of independent computations performed by researchers in the US and Europe are presented for two generic configurations (double cone and cylinder) and compared with experimental data. The results illustrate the current capabilities and limitations of modern CFD methods for these flows.

The RAVE/VERTIGO vertex reconstruction toolkit and framework

NASA Astrophysics Data System (ADS)

Waltenberger, W.; Mitaroff, W.; Moser, F.; Pflugfelder, B.; Riedel, H. V.

2008-07-01

A detector-independent toolkit for vertex reconstruction (RAVE1) is being developed, along with a standalone framework (VERTIGO2) for testing, analyzing and debugging. The core algorithms represent state-of-the-art for geometric vertex finding and fitting by both linear (Kalman filter) and robust estimation methods. Main design goals are ease of use, flexibility for embedding into existing software frameworks, extensibility, and openness. The implementation is based on modern object-oriented techniques, is coded in C++ with interfaces for Java and Python, and follows an open-source approach. A beta release is available.

Modular method of detection, localization, and counting of multiple-taxon pollen apertures using bag-of-words

NASA Astrophysics Data System (ADS)

Lozano-Vega, Gildardo; Benezeth, Yannick; Marzani, Franck; Boochs, Frank

2014-09-01

Accurate recognition of airborne pollen taxa is crucial for understanding and treating allergic diseases which affect an important proportion of the world population. Modern computer vision techniques enable the detection of discriminant characteristics. Apertures are among the important characteristics which have not been adequately explored until now. A flexible method of detection, localization, and counting of apertures of different pollen taxa with varying appearances is proposed. Aperture description is based on primitive images following the bag-of-words strategy. A confidence map is estimated based on the classification of sampled regions. The method is designed to be extended modularly to new aperture types employing the same algorithm by building individual classifiers. The method was evaluated on the top five allergenic pollen taxa in Germany, and its robustness to unseen particles was verified.

Thermal Hydraulics Design and Analysis Methodology for a Solid-Core Nuclear Thermal Rocket Engine Thrust Chamber

NASA Technical Reports Server (NTRS)

Wang, Ten-See; Canabal, Francisco; Chen, Yen-Sen; Cheng, Gary; Ito, Yasushi

2013-01-01

Nuclear thermal propulsion is a leading candidate for in-space propulsion for human Mars missions. This chapter describes a thermal hydraulics design and analysis methodology developed at the NASA Marshall Space Flight Center, in support of the nuclear thermal propulsion development effort. The objective of this campaign is to bridge the design methods in the Rover/NERVA era, with a modern computational fluid dynamics and heat transfer methodology, to predict thermal, fluid, and hydrogen environments of a hypothetical solid-core, nuclear thermal engine the Small Engine, designed in the 1960s. The computational methodology is based on an unstructured-grid, pressure-based, all speeds, chemically reacting, computational fluid dynamics and heat transfer platform, while formulations of flow and heat transfer through porous and solid media were implemented to describe those of hydrogen flow channels inside the solid24 core. Design analyses of a single flow element and the entire solid-core thrust chamber of the Small Engine were performed and the results are presented herein

The End of the Rainbow? Color Schemes for Improved Data Graphics

NASA Astrophysics Data System (ADS)

Light, Adam; Bartlein, Patrick J.

2004-10-01

Modern computer displays and printers enable the widespread use of color in scientific communication, but the expertise for designing effective graphics has not kept pace with the technology for producing them. Historically, even the most prestigious publications have tolerated high defect rates in figures and illustrations, and technological advances that make creating and reproducing graphics easier do not appear to have decreased the frequency of errors. Flawed graphics consequently beget more flawed graphics as authors emulate published examples. Color has the potential to enhance communication, but design mistakes can result in color figures that are less effective than gray scale displays of the same data. Empirical research on human subjects can build a fundamental understanding of visual perception and scientific methods can be used to evaluate existing designs, but creating effective data graphics is a design task and not fundamentally a scientific pursuit. Like writing well, creating good data graphics requires a combination of formal knowledge and artistic sensibility tempered by experience: a combination of ``substance, statistics, and design''.

Integrating reliability and maintainability into a concurrent engineering environment

NASA Astrophysics Data System (ADS)

Phillips, Clifton B.; Peterson, Robert R.

1993-02-01

This paper describes the results of a reliability and maintainability study conducted at the University of California, San Diego and supported by private industry. Private industry thought the study was important and provided the university access to innovative tools under cooperative agreement. The current capability of reliability and maintainability tools and how they fit into the design process is investigated. The evolution of design methodologies leading up to today's capability is reviewed for ways to enhance the design process while keeping cost under control. A method for measuring the consequences of reliability and maintainability policy for design configurations in an electronic environment is provided. The interaction of selected modern computer tool sets is described for reliability, maintainability, operations, and other elements of the engineering design process. These tools provide a robust system evaluation capability that brings life cycle performance improvement information to engineers and their managers before systems are deployed, and allow them to monitor and track performance while it is in operation.

Stepwise Regression Analysis of MDOE Balance Calibration Data Acquired at DNW

NASA Technical Reports Server (NTRS)

DeLoach, RIchard; Philipsen, Iwan

2007-01-01

This paper reports a comparison of two experiment design methods applied in the calibration of a strain-gage balance. One features a 734-point test matrix in which loads are varied systematically according to a method commonly applied in aerospace research and known in the literature of experiment design as One Factor At a Time (OFAT) testing. Two variations of an alternative experiment design were also executed on the same balance, each with different features of an MDOE experiment design. The Modern Design of Experiments (MDOE) is an integrated process of experiment design, execution, and analysis applied at NASA's Langley Research Center to achieve significant reductions in cycle time, direct operating cost, and experimental uncertainty in aerospace research generally and in balance calibration experiments specifically. Personnel in the Instrumentation and Controls Department of the German Dutch Wind Tunnels (DNW) have applied MDOE methods to evaluate them in the calibration of a balance using an automated calibration machine. The data have been sent to Langley Research Center for analysis and comparison. This paper reports key findings from this analysis. The chief result is that a 100-point calibration exploiting MDOE principles delivered quality comparable to a 700+ point OFAT calibration with significantly reduced cycle time and attendant savings in direct and indirect costs. While the DNW test matrices implemented key MDOE principles and produced excellent results, additional MDOE concepts implemented in balance calibrations at Langley Research Center are also identified and described.

Interactions of neanderthals and modern humans: what can be inferred from mitochondrial DNA?

PubMed

Cyran, Krzysztof A; Kimmel, Marek

2005-07-01

This paper reviews the state-of-the-art knowledge concerning the relationship between Neanderthals and Upper Paleolithic modern humans. The branching-process method is applied to infer the upper limit of hypothetical Neanderthal admixture, consistent with the evidence based on mitochon- drial DNA sequences of contemporary modern humans, as well as Neanderthal and early modern European H. sapiens fossils. As a result, a maximum value of 15% admixture is obtained. This estimate is discussed in the context of its consequences for the two competing theories of modern human origin.

Comparative Study of Barotrauma Risk during Fish Passage through Kaplan Turbines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richmond, Marshall C.; Romero-Gomez, Pedro; Serkowski, John A.

Rapid pressure changes in hydroelectric turbine flows can cause barotrauma that can be hazardous to the passage of fish, in particular migratory juvenile salmonids. Although numerous laboratory tests have evaluated the effect of rapid decompression in fish species of relevance, numerical modeling studies offer the advantage of predicting, for new turbine designs, the potential risks of mortality and injury from rapid pressure change during turbine passage. However, rapid pressure change is only one of several hydraulic risks encountered by fish during turbine passage in addition to blade strike, shear, and turbulence. To better understand the role of rapid pressure changes,more » the present work focuses on the application of a computational fluid dynamics based method for evaluating the risk of pressure-related mortality to fish passing through an early 1960s era original hydroelectric Kaplan turbine at Wanapum Dam (Columbia River, Washington), and a modern advanced Kaplan turbine installed in 2005. The results show that the modeling approach acceptably reproduced the nadir pressure distributions compared to field data previously collected at the site using an autonomous sensor. Our findings show that the new advanced-design unit performs better, in terms of reduced barotrauma risk to fish from exposure to low pressures, than the original turbine unit. The outcomes allow for comparative analyses of turbine designs and operations prior to installation, an advantage that can potentially be integrated in the process of designing new turbine units to achieve superior environmental performance. Overall, the results show that modern turbine designs can achieve the multiple objectives of increasing power generation, lowering cavitation potential, and reducing barotrauma risks to passing fish.« less

Modern methods of surveyor observations in opencast mining under complex hydrogeological conditions.

NASA Astrophysics Data System (ADS)

Usoltseva, L. A.; Lushpei, V. P.; Mursin, VA

2017-10-01

The article considers the possibility of linking the modern methods of surveying security of open mining works to improve industrial safety in the Primorsky Territory, as well as their use in the educational process. Industrial Safety in the management of Surface Mining depends largely on the applied assessment methods and methods of stability of pit walls and slopes of dumps in the complex mining and hydro-geological conditions.

GridLAB-D: An Agent-Based Simulation Framework for Smart Grids

DOE PAGES

Chassin, David P.; Fuller, Jason C.; Djilali, Ned

2014-01-01

Simulation of smart grid technologies requires a fundamentally new approach to integrated modeling of power systems, energy markets, building technologies, and the plethora of other resources and assets that are becoming part of modern electricity production, delivery, and consumption systems. As a result, the US Department of Energy’s Office of Electricity commissioned the development of a new type of power system simulation tool called GridLAB-D that uses an agent-based approach to simulating smart grids. This paper presents the numerical methods and approach to time-series simulation used by GridLAB-D and reviews applications in power system studies, market design, building control systemmore » design, and integration of wind power in a smart grid.« less

GridLAB-D: An Agent-Based Simulation Framework for Smart Grids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chassin, David P.; Fuller, Jason C.; Djilali, Ned

2014-06-23

Simulation of smart grid technologies requires a fundamentally new approach to integrated modeling of power systems, energy markets, building technologies, and the plethora of other resources and assets that are becoming part of modern electricity production, delivery, and consumption systems. As a result, the US Department of Energy’s Office of Electricity commissioned the development of a new type of power system simulation tool called GridLAB-D that uses an agent-based approach to simulating smart grids. This paper presents the numerical methods and approach to time-series simulation used by GridLAB-D and reviews applications in power system studies, market design, building control systemmore » design, and integration of wind power in a smart grid.« less

Application of Modern Design of Experiments to CARS Thermometry in a Model Scramjet Engine

NASA Technical Reports Server (NTRS)

Danehy, P. M.; DeLoach, R.; Cutler, A. D.

2002-01-01

We have applied formal experiment design and analysis to optimize the measurement of temperature in a supersonic combustor at NASA Langley Research Center. We used the coherent anti-Stokes Raman spectroscopy (CARS) technique to map the temperature distribution in the flowfield downstream of an 1160 K, Mach 2 freestream into which supersonic hydrogen fuel is injected at an angle of 30 degrees. CARS thermometry is inherently a single-point measurement technique; it was used to map thc flow by translating the measurement volume through the flowfield. The method known as "Modern Design of Experiments" (MDOE) was used to estimate the data volume required, design the test matrix, perform the experiment and analyze the resulting data. MDOE allowed us to match the volume of data acquired to the precision requirements of the customer. Furthermore, one aspect of MDOE, known as response surface methodology, allowed us to develop precise maps of the flowfield temperature, allowing interpolation between measurement points. An analytic function in two spatial variables was fit to the data from a single measurement plane. Fitting with a Cosine Series Bivariate Function allowed the mean temperature to be mapped with 95% confidence interval half-widths of +/- 30 Kelvin, comfortably meeting the confidence of +/- 50 Kelvin specified prior to performing the experiments. We estimate that applying MDOE to the present experiment saved a factor of 5 in data volume acquired, compared to experiments executed in the traditional manner. Furthermore, the precision requirements could have been met with less than half the data acquired.

Viral vaccines and their manufacturing cell substrates: New trends and designs in modern vaccinology.

PubMed

Rodrigues, Ana F; Soares, Hugo R; Guerreiro, Miguel R; Alves, Paula M; Coroadinha, Ana S

2015-09-01

Vaccination is one of the most effective interventions in global health. The worldwide vaccination programs significantly reduced the number of deaths caused by infectious agents. A successful example was the eradication of smallpox in 1979 after two centuries of vaccination campaigns. Since the first variolation administrations until today, the knowledge on immunology has increased substantially. This knowledge combined with the introduction of cell culture and DNA recombinant technologies revolutionized vaccine design. This review will focus on vaccines against human viral pathogens, recent developments on vaccine design and cell substrates used for their manufacture. While the production of attenuated and inactivated vaccines requires the use of the respective permissible cell substrates, the production of recombinant antigens, virus-like particles, vectored vaccines and chimeric vaccines requires the use - and often the development - of specific cell lines. Indeed, the development of novel modern viral vaccine designs combined with, the stringent safety requirements for manufacture, and the better understanding on animal cell metabolism and physiology are increasing the awareness on the importance of cell line development and engineering areas. A new era of modern vaccinology is arriving, offering an extensive toolbox to materialize novel and creative ideas in vaccine design and its manufacture. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Modernization of vertical Pelton turbines with the help of CFD and model testing

NASA Astrophysics Data System (ADS)

Mack, Reiner; Gola, Bartlomiej; Smertnig, Martin; Wittwer, Bernhard; Meusburger, Peter

2014-03-01

The modernization of water turbines bears a high potential of increasing the already installed hydropower capacity. In many projects the existing waterways allow a substantial increase of the available flow capacity and with it the energy output. But also the upgrading onto a state of the art hydraulic, mechanical and electrical design will increase the available power considerably after the rehabilitation. The two phase nature of the flow in Pelton turbines requires for the hydraulic refurbishment special care in the application of the available design methods. Where the flow in the high pressure section of the turbine is mainly of one phase nature, CFD has been used as a standard tool for many years. Also the jet quality, and with it the exploration of the source of flow disturbances that cause poor free surface quality can be investigated with CFD. The interaction of the jet with the buckets of the runner is also examined by means of CFD. However, its accuracy with respect to hydraulic efficiency is, because of the two phase flow and the transient flow process, in very few cases good enough for a reliable and accurate prediction of absolute numbers. The optimization of hydraulic bucket profiles is therefore always checked with measurements in homologous scaled model turbines. A similar situation exists for the housing flow after the water is discharged from the runner. Here also CFD techniques are available to explore the general mechanisms. However, due to the two phase flow nature, where only a very small space is filled with moving water, the experimental setup in a model turbine is always the final proof for optimizations of housing inserts and modifications. The hydraulic design of a modernization project for a power station equipped with vertical Pelton turbines of two different designs is described in the proposed paper. It will be shown, how CFD is applied to determine the losses in the high pressure section and how these results are combined with the model tests carried out in the hydraulic laboratory. Finally a comparison is made in between the achieved model turbine results with measurements carried out in the prototype.

Single-pass memory system evaluation for multiprogramming workloads

NASA Technical Reports Server (NTRS)

Conte, Thomas M.; Hwu, Wen-Mei W.

1990-01-01

Modern memory systems are composed of levels of cache memories, a virtual memory system, and a backing store. Varying more than a few design parameters and measuring the performance of such systems has traditionally be constrained by the high cost of simulation. Models of cache performance recently introduced reduce the cost simulation but at the expense of accuracy of performance prediction. Stack-based methods predict performance accurately using one pass over the trace for all cache sizes, but these techniques have been limited to fully-associative organizations. This paper presents a stack-based method of evaluating the performance of cache memories using a recurrence/conflict model for the miss ratio. Unlike previous work, the performance of realistic cache designs, such as direct-mapped caches, are predicted by the method. The method also includes a new approach to the problem of the effects of multiprogramming. This new technique separates the characteristics of the individual program from that of the workload. The recurrence/conflict method is shown to be practical, general, and powerful by comparing its performance to that of a popular traditional cache simulator. The authors expect that the availability of such a tool will have a large impact on future architectural studies of memory systems.

IFRP studies child-spacing trends in subSaharan Africa.

PubMed

1981-10-01

The IFRP (International Fertility Research Program) conducted in late 1980 a study of the changing patterns of breast feeding, postpartum abstinence, and use of modern contraceptive methods among women of reproductive age in Lagos, Nigeria, the largest city in tropical Africa. There is concern among family planning experts that the traditional child-spacing practices are breaking down in subSaharan Africa without being replaced sufficiently with modern fertility control methods. The household survey showed a total fertility rate of 6.56. Compared to the mean cumulative fertility of 6.19 for women aged 45-49, it appears that fertility is actually increasing in Lagos. There were low levels of awareness and practice of modern family planning methods reported by these women. Less than 1/4 were using a method of family planning currently. Of these, 7% were using a modern method (mostly pills), 3% were using a conventional method (condoms), and 14% were using only a traditional method. Many of these women did not consider either breast feeding or sexual abstinence as means of contraception. Breast feeding was practiced by 85% of the women during the 1st 2 months, with rates falling off sharply after that. Child spacing rather than fertility limitation was the motivation of most of the women practicing family planning.

A guide to missing data for the pediatric nephrologist.

PubMed

Larkins, Nicholas G; Craig, Jonathan C; Teixeira-Pinto, Armando

2018-03-13

Missing data is an important and common source of bias in clinical research. Readers should be alert to and consider the impact of missing data when reading studies. Beyond preventing missing data in the first place, through good study design and conduct, there are different strategies available to handle data containing missing observations. Complete case analysis is often biased unless data are missing completely at random. Better methods of handling missing data include multiple imputation and models using likelihood-based estimation. With advancing computing power and modern statistical software, these methods are within the reach of clinician-researchers under guidance of a biostatistician. As clinicians reading papers, we need to continue to update our understanding of statistical methods, so that we understand the limitations of these techniques and can critically interpret literature.

Automatic high-throughput screening of colloidal crystals using machine learning

NASA Astrophysics Data System (ADS)

Spellings, Matthew; Glotzer, Sharon C.

Recent improvements in hardware and software have united to pose an interesting problem for computational scientists studying self-assembly of particles into crystal structures: while studies covering large swathes of parameter space can be dispatched at once using modern supercomputers and parallel architectures, identifying the different regions of a phase diagram is often a serial task completed by hand. While analytic methods exist to distinguish some simple structures, they can be difficult to apply, and automatic identification of more complex structures is still lacking. In this talk we describe one method to create numerical ``fingerprints'' of local order and use them to analyze a study of complex ordered structures. We can use these methods as first steps toward automatic exploration of parameter space and, more broadly, the strategic design of new materials.

Improved genome-scale multi-target virtual screening via a novel collaborative filtering approach to cold-start problem

PubMed Central

Lim, Hansaim; Gray, Paul; Xie, Lei; Poleksic, Aleksandar

2016-01-01

Conventional one-drug-one-gene approach has been of limited success in modern drug discovery. Polypharmacology, which focuses on searching for multi-targeted drugs to perturb disease-causing networks instead of designing selective ligands to target individual proteins, has emerged as a new drug discovery paradigm. Although many methods for single-target virtual screening have been developed to improve the efficiency of drug discovery, few of these algorithms are designed for polypharmacology. Here, we present a novel theoretical framework and a corresponding algorithm for genome-scale multi-target virtual screening based on the one-class collaborative filtering technique. Our method overcomes the sparseness of the protein-chemical interaction data by means of interaction matrix weighting and dual regularization from both chemicals and proteins. While the statistical foundation behind our method is general enough to encompass genome-wide drug off-target prediction, the program is specifically tailored to find protein targets for new chemicals with little to no available interaction data. We extensively evaluate our method using a number of the most widely accepted gene-specific and cross-gene family benchmarks and demonstrate that our method outperforms other state-of-the-art algorithms for predicting the interaction of new chemicals with multiple proteins. Thus, the proposed algorithm may provide a powerful tool for multi-target drug design. PMID:27958331

Improved genome-scale multi-target virtual screening via a novel collaborative filtering approach to cold-start problem.

PubMed

Lim, Hansaim; Gray, Paul; Xie, Lei; Poleksic, Aleksandar

2016-12-13

Conventional one-drug-one-gene approach has been of limited success in modern drug discovery. Polypharmacology, which focuses on searching for multi-targeted drugs to perturb disease-causing networks instead of designing selective ligands to target individual proteins, has emerged as a new drug discovery paradigm. Although many methods for single-target virtual screening have been developed to improve the efficiency of drug discovery, few of these algorithms are designed for polypharmacology. Here, we present a novel theoretical framework and a corresponding algorithm for genome-scale multi-target virtual screening based on the one-class collaborative filtering technique. Our method overcomes the sparseness of the protein-chemical interaction data by means of interaction matrix weighting and dual regularization from both chemicals and proteins. While the statistical foundation behind our method is general enough to encompass genome-wide drug off-target prediction, the program is specifically tailored to find protein targets for new chemicals with little to no available interaction data. We extensively evaluate our method using a number of the most widely accepted gene-specific and cross-gene family benchmarks and demonstrate that our method outperforms other state-of-the-art algorithms for predicting the interaction of new chemicals with multiple proteins. Thus, the proposed algorithm may provide a powerful tool for multi-target drug design.

Life cycle management of analytical methods.

PubMed

Parr, Maria Kristina; Schmidt, Alexander H

2018-01-05

In modern process management, the life cycle concept gains more and more importance. It focusses on the total costs of the process from invest to operation and finally retirement. Also for analytical procedures an increasing interest for this concept exists in the recent years. The life cycle of an analytical method consists of design, development, validation (including instrumental qualification, continuous method performance verification and method transfer) and finally retirement of the method. It appears, that also regulatory bodies have increased their awareness on life cycle management for analytical methods. Thus, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), as well as the United States Pharmacopeial Forum discuss the enrollment of new guidelines that include life cycle management of analytical methods. The US Pharmacopeia (USP) Validation and Verification expert panel already proposed a new General Chapter 〈1220〉 "The Analytical Procedure Lifecycle" for integration into USP. Furthermore, also in the non-regulated environment a growing interest on life cycle management is seen. Quality-by-design based method development results in increased method robustness. Thereby a decreased effort is needed for method performance verification, and post-approval changes as well as minimized risk of method related out-of-specification results. This strongly contributes to reduced costs of the method during its life cycle. Copyright © 2017 Elsevier B.V. All rights reserved.

Inclusive design in the implementation of projects for schools modernization in Portugal - case studies.

PubMed

Lopes, Lígia; Aguiar, Carlos; da Silva, Fernando Moreira

2012-01-01

The Project for Schools Modernization taking place in Portugal, with an estimated total investment of 2450 million for the intervention in the first 205 schools, provide the reclassification of 332 secondary schools by 2015. One of the questions we can pose is if the authorities and the teams of architects selected to design these schools considered fundamental for the correctness of architectural barriers within the school and its accessibility the implementation of standards and principles of inclusion of children/teenagers with special needs within their school environment. As most of the projects are already being implemented, the main aim of this paper is to present the outcomes of a comparative analysis and synthesis of six schools located in the northern part of the country. This analysis occurs from the of Participatory Design perspective which appeals to the experience of the disable children to look (or evaluate) the negative and positive factors in terms of physical space, interpreted by inclusive design rules and orientations. Therefore, the evaluation of schools modernization project, and its discussion, is central for the understanding how these children are addressed in projects which are directed at them.

Development of quantitative structure-activity relationships and its application in rational drug design.

PubMed

Yang, Guang-Fu; Huang, Xiaoqin

2006-01-01

Over forty years have elapsed since Hansch and Fujita published their pioneering work of quantitative structure-activity relationships (QSAR). Following the introduction of Comparative Molecular Field Analysis (CoMFA) by Cramer in 1998, other three-dimensional QSAR methods have been developed. Currently, combination of classical QSAR and other computational techniques at three-dimensional level is of greatest interest and generally used in the process of modern drug discovery and design. During the last several decades, a number of different mythologies incorporating a range of molecular descriptors and different statistical regression ways have been proposed and successfully applied in developing of new drugs, thus QSAR method has been proven to be indispensable in not only the reliable prediction of specific properties of new compounds, but also the help to elucidate the possible molecular mechanism of the receptor-ligand interactions. Here, we review the recent developments in QSAR and their applications in rational drug design, focusing on the reasonable selection of novel molecular descriptors and the construction of predictive QSAR models by the help of advanced computational techniques.

Design of dual energy x-ray detector for conveyor belt with steel wire ropes

NASA Astrophysics Data System (ADS)

Dai, Yue; Miao, Changyun; Rong, Feng

2009-07-01

A dual energy X-ray detector for conveyor belt with steel wire ropes is researched in the paper. Conveyor belt with steel wire ropes is one of primary transfer equipments in modern production. The traditional test methods like electromagnetic induction principle could not display inner image of steel wire ropes directly. So X-ray detection technology has used to detect the conveyor belt. However the image was not so clear by the interference of the rubber belt. Therefore, the dualenergy X-ray detection technology with subtraction method is developed to numerically remove the rubber belt from radiograph, thus improving the definition of the ropes image. The purpose of this research is to design a dual energy Xray detector that could make the operator easier to found the faulty of the belt. This detection system is composed of Xray source, detector controlled by FPGA chip, PC for running image processing system and so on. With the result of the simulating, this design really improved the capability of the staff to test the conveyor belt.

Baseline Evaluations to Support Control Room Modernization at Nuclear Power Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boring, Ronald L.; Joe, Jeffrey C.

2015-02-01

For any major control room modernization activity at a commercial nuclear power plant (NPP) in the U.S., a utility should carefully follow the four phases prescribed by the U.S. Nuclear Regulatory Commission in NUREG-0711, Human Factors Engineering Program Review Model. These four phases include Planning and Analysis, Design, Verification and Validation, and Implementation and Operation. While NUREG-0711 is a useful guideline, it is written primarily from the perspective of regulatory review, and it therefore does not provide a nuanced account of many of the steps the utility might undertake as part of control room modernization. The guideline is largely summative—intendedmore » to catalog final products—rather than formative—intended to guide the overall modernization process. In this paper, we highlight two crucial formative sub-elements of the Planning and Analysis phase specific to control room modernization that are not covered in NUREG-0711. These two sub-elements are the usability and ergonomics baseline evaluations. A baseline evaluation entails evaluating the system as-built and currently in use. The usability baseline evaluation provides key insights into operator performance using the control system currently in place. The ergonomics baseline evaluation identifies possible deficiencies in the physical configuration of the control system. Both baseline evaluations feed into the design of the replacement system and subsequent summative benchmarking activities that help ensure that control room modernization represents a successful evolution of the control system.« less

Use of a Modern Polymerization Pilot-Plant for Undergraduate Control Projects.

ERIC Educational Resources Information Center

Mendoza-Bustos, S. A.; And Others

1991-01-01

Described is a project where students gain experience in handling large volumes of hazardous materials, process start up and shut down, equipment failures, operational variations, scaling up, equipment cleaning, and run-time scheduling while working in a modern pilot plant. Included are the system design, experimental procedures, and results. (KR)

English 7-8: Modern Media of Communication.

ERIC Educational Resources Information Center

McGowan, Madelon

This grade 7-8 level course guide covers aspects of media communication such as verbal and nonverbal communication theory, forms of modern media (newspapers, feature films, artistic films, music, advertising, etc.), and practice for the student in the various aspects of communication media. The guide is designed for a one-year course and enhances…

Teacher's Guide to SERAPHIM Software III. Modern Chemistry.

ERIC Educational Resources Information Center

Bogner, Donna J.

Designed to assist chemistry teachers in selecting appropriate software programs, this publication is the third in a series of six teacher's guides from Project SERAPHIM, a program sponsored by the National Science Foundation. This guide is keyed to the chapters of the text "Modern Chemistry." Program suggestions are arranged in the same…

Teacher's Guide to SERAPHIM Software IV Chemistry: A Modern Course.

ERIC Educational Resources Information Center

Bogner, Donna J.

Designed to assist chemistry teachers in selecting appropriate software programs, this publication is the fourth in a series of six teacher's guides from Project SERAPHIM, a program sponsored by the National Science Foundation. This guide is keyed to the chapters of the text "Chemistry: A Modern Course." Program suggestions are arranged…

76 FR 63909 - Draft Programmatic Environmental Impact Statement (EIS) for Modernization of Training...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-14

... the training requirements of military units in Hawai`i. This modernization would improve the quality... at PTA are old, are operating beyond their useful life and do not meet current DoD design standards... with the possible effects to air quality, historic resources, and threatened and endangered species...

A Strategy for Replacing Sum Scoring

ERIC Educational Resources Information Center

Ramsay, James O.; Wiberg, Marie

2017-01-01

This article promotes the use of modern test theory in testing situations where sum scores for binary responses are now used. It directly compares the efficiencies and biases of classical and modern test analyses and finds an improvement in the root mean squared error of ability estimates of about 5% for two designed multiple-choice tests and…

A "Language" of Modernization: Culture and Art Education in the Village Institutes

ERIC Educational Resources Information Center

Kaynar, Mete Kaan; Ak, Gökhan

2017-01-01

The Village Institutes were originally-designed in-place-training institutions of the Turkish education history. They had been a very significant and unique educational-product of Turkey which were gifted to all secular [modern] world education systems. Because these Institutes were explored in line with thoroughly native considerations and…

Commodification of Ghana's Volta River: An Example of Ellul's Autonomy of Technique

ERIC Educational Resources Information Center

Agbemabiese, Lawrence; Byrne, John

2005-01-01

Jacques Ellul argued that modernity's nearly exclusive reliance on science and technology to design society would threaten human freedom. Of particular concern for Ellul was the prospect of the technical milieu overwhelming culture. The commodification of the Volta River in order to modernize Ghana illustrates the Ellulian dilemma of the autonomy…

The Development of the Foundations of Modern Pedagogy: Paradigmal and Methodological Aspects of Research

ERIC Educational Resources Information Center

Dmitrenko, ?amara ?.; Lavryk, Tatjana V.; Yaresko, Ekaterina V.

2015-01-01

Changes in the various fields of knowledge influenced the pedagogical science. The article explains the structure of the foundations of modern pedagogy through paradigmal and methodological aspects. Bases of modern pedagogy include complex of paradigms, object and subject of science, general and specific principles, methods and technologies.…

Role of Media Rumors in the Modern Society

ERIC Educational Resources Information Center

Zheltukhina, Marina R.; Slyshkin, Gennady G.; Ponomarenko, Elena B.; Busygina, Maryana V.; Omelchenko, Anatoly V.

2016-01-01

The article examines the using of media rumors as pragmatic influence mechanism in the modern communication. The printed and electronic messages with rumors make the material of research. The complex methods of analysis of the rumors role in the modern society are used. The inductive, descriptive and comparative, cognitive and discursive,…

Heating and Cooling System Design for a Modern Transportable Container

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berger, Jason E.

Sandia National Laboratories (SNL) has been tasked with the design of a modern transportable container (MTC) for use in high reliability transportation environments. The container is required to transport cargo capable of generating its own heat and operate under the United States’ climatic extremes. In response to these requirements, active heating and cooling is necessary to maintain a controlled environment inside the container. The following thesis project documents the design of an active heating, active cooling, and combined active heating and cooling system (now referred to as active heating and cooling systems) through computational thermal analyses, scoping of commercial systemmore » options, and mechanical integration with the container’s structure.« less

Digitally recycled incubators: better economic alternatives to modern systems in low-income countries.

PubMed

Amadi, H O; Mokuolu, O A; Adimora, G N; Pam, S D; Etawo, U S; Ohadugha, C O; Adesiyun, O O

2007-09-01

The need to maintain a neutral thermal environment is critical to newborn care. To investigate reasons for the insufficiency of functional incubators and develop a cost-effective technique for using electronic digital components to recycle obsolete incubators in Nigeria. Following interview of 84 clinicians and administrators in Nigerian hospitals, it was identified that inadequate funding was the main reason for lack of functional incubators. Two groups of incubator units were then created and their performance compared. Sixteen units of modern (group A) and 19 units of obsolete (group B) incubators were obtained from six hospitals. An assembly design applying independent generic components for recycling systems was specified and produced. These were sourced through the internet at competitive cost and fitted into the reconstructed panels of the obsolete systems. The functional performance of each recycled system was rigorously monitored for 6 months and graded using ten performance indices. The same indices were used to quantify group A systems. The performance of the recycled incubators (group B) was found to be similar to those of modern incubators. Group B's cost index was found to be 25% of that of group A's. Appropriate incubator recycling is a cost-effective method of re-equipping hospitals in low-income countries.

Human Factors Guidance for Control Room and Digital Human-System Interface Design and Modification, Guidelines for Planning, Specification, Design, Licensing, Implementation, Training, Operation and Maintenance

DOE Office of Scientific and Technical Information (OSTI.GOV)

R. Fink, D. Hill, J. O'Hara

2004-11-30

Nuclear plant operators face a significant challenge designing and modifying control rooms. This report provides guidance on planning, designing, implementing and operating modernized control rooms and digital human-system interfaces.

Teaching Strategies and Methods in Modern Environments for Learning of Programming

ERIC Educational Resources Information Center

Djenic, Slobodanka; Mitic, Jelena

2017-01-01

This paper presents teaching strategies and methods, applicable in modern blended environments for learning of programming. Given the fact that the manner of applying teaching strategies always depends on the specific requirements of a certain area of learning, the paper outlines the basic principles of teaching in programming courses, as well as…

Effectiveness of additional self-care acupressure for women with menstrual pain compared to usual care alone: using stakeholder engagement to design a pragmatic randomized trial and study protocol.

PubMed

Blödt, Susanne; Schützler, Lena; Huang, Wenjing; Pach, Daniel; Brinkhaus, Benno; Hummelsberger, Josef; Kirschbaum, Barbara; Kuhlmann, Kirsten; Lao, Lixing; Liang, Fanrong; Mietzner, Anna; Mittring, Nadine; Müller, Sabine; Paul, Anna; Pimpao-Niederle, Carolina; Roll, Stephanie; Wu, Huangan; Zhu, Jiang; Witt, Claudia M

2013-04-11

Self-care acupressure might be successful in treating menstrual pain, which is common among young women. There is a need for comparative effectiveness research with stakeholder engagement in all phases seeking to address the needs of decision-makers. Our aim was to design a study on the effectiveness of additional self-care acupressure for menstrual pain comparing usual care alone using different methods of stakeholder engagement. The study was designed using multiple mixed methods for stakeholder engagement. Based on the results of a survey and focus group discussion, a stakeholder advisory group developed the study design. Stakeholder engagement resulted in a two-arm pragmatic randomized trial. Two hundred and twenty women aged 18 to 25 years with menstrual pain will be included in the study. Outcome measurement will be done using electronic questionnaires provided by a study specific mobile application (App). Primary outcome will be the mean pain intensity at the days of pain during the third menstruation after therapy start. Stakeholder engagement helped to develop a study design that better serves the needs of decision makers, including an App as a modern tool for both intervention and data collection in a young target group. Clinicaltrials.gov identifier http://NCT01582724.

[The problems of cataract surgery and intraocular correction: Russian school achievements and modern trends].

PubMed

Maliugin, B E; Linnik, L F; Egorova, E V; Kopaeva, V G; Tolchinskaia, A I

2007-01-01

The development of the safest and, at the same time, efficient methods of cataract surgery, is not only a topical task of medical science and practice, but also, taking the demographic situation into account, a solution to a social problem. The article describes the main achievements of academician S. N. Fyodorov's school in the field of cataract surgery with intraocular lense (IOL) implantation. Special attention is paid to the key components of cataract extraction technique named "small incision surgery", which is based upon the use of ultrasmall surgical approaches with self-sealing ability and no need for suturing. The main advantages and disadvantages of various types of cataract lense fragmentation, including ultrasound emulsification, mechanic and hydraulic fragmentation, and laser destruction, are described. Topical issues concerning cataract extraction technique under the conditions of complicating ophthalmopathology including the weakness of ciliary zonule system, high-degree myopia, glaucoma, pseudoexfoliative syndrome, small pupil, past injuries and eye surgery, are outlined. The paper also reflects a new qualitative step in the development of intraocular aphakia correction technique under modern conditions. Basic requirements to design parameters and IOL materials are determined from the position of reestablishing the accommodative function and fine visual functions. Ways of IOL design improvement are described especially for their application in non-standard and complicated cases.

The Application of Modern Powder Characterisation Methods in Product and Process Development of Solid Dosage Forms.

PubMed

Freeman, Tim; Brockbank, Katrina; Armstrong, Brian

2015-01-01

The pharmaceutical industry still produces the vast majority of their products, from powdered ingredients, in the form of solid doses. Despite their ubiquity, powders are difficult materials to characterise and understand, as evidenced by the frequent problems encountered during manufacture. The reason for this is their complex rheological behaviour coupled with numerous environmental variations, such as humidity. Equally, the range of processes used to manipulate powders subject them to extremes of stress from high compaction loads seen in compactors to the dispersed state seen in fluidised bed dryers. Thus, it is evident that ensuring that the powders characteristics are compatible with the way they are to be processed is a clear prerequisite for today's Quality by Design driven manufacturing. Modern, computer controlled instrumental techniques, including the dynamic, bulk and shear property measurements have enabled direct measurements of a powders response to aeration, consolidation and flow rate - all at low stresses - as well as quantifying shear and bulk properties (such as density, compressibility and permeability). In order to demonstrate how fully characterising a powder can be used in the design, operation and troubleshooting of processes, this paper will present examples of common pharmaceutical unit operations and the different powder characteristics that most influence the performance of each.

Optical nano-biosensing interface via nucleic acid amplification strategy: construction and application.

PubMed

Zhou, Hong; Liu, Jing; Xu, Jing-Juan; Zhang, Shu-Sheng; Chen, Hong-Yuan

2018-03-21

Modern optical detection technology plays a critical role in current clinical detection due to its high sensitivity and accuracy. However, higher requirements such as extremely high detection sensitivity have been put forward due to the clinical needs for the early finding and diagnosing of malignant tumors which are significant for tumor therapy. The technology of isothermal amplification with nucleic acids opens up avenues for meeting this requirement. Recent reports have shown that a nucleic acid amplification-assisted modern optical sensing interface has achieved satisfactory sensitivity and accuracy, high speed and specificity. Compared with isothermal amplification technology designed to work completely in a solution system, solid biosensing interfaces demonstrated better performances in stability and sensitivity due to their ease of separation from the reaction mixture and the better signal transduction on these optical nano-biosensing interfaces. Also the flexibility and designability during the construction of these nano-biosensing interfaces provided a promising research topic for the ultrasensitive detection of cancer diseases. In this review, we describe the construction of the burgeoning number of optical nano-biosensing interfaces assisted by a nucleic acid amplification strategy, and provide insightful views on: (1) approaches to the smart fabrication of an optical nano-biosensing interface, (2) biosensing mechanisms via the nucleic acid amplification method, (3) the newest strategies and future perspectives.

[Balneotherapy and spa therapy of rheumatic diseases in Turkey: a systematic review].

PubMed

Karagülle, M Z; Karagülle, M

2004-02-01

Turkey has a lot of thermal and mineral springs and is looking back on a still vivid tradition of spa therapy and balneotherapy, applied especially for the treatment of rheumatic diseases. This tradition is predominantly empiric and intuitive, however, it has assumed some important aspects of modern balneotherapeutic methods as well. This article is aimed at presenting the characteristics of traditional and modern balneological and spa therapy forms in Turkey. The studies which have been conducted between 1990 and 2000 in different spas in Turkey on the efficacy and effectiveness of spa therapy and balneotherapy for rheumatic diseases have been searched and analyzed independent of their design. A descriptive evaluation of the studies was carried out. A total of 15 published studies have been found and analyzed. The investigations have been carried out in 8 different spa resorts in Turkey. In these studies the effectiveness and efficacy of different balneological and spa therapies on a variety of rheumatic diseases (from osteoarthritis to fibromyalgia and from rheumatoid arthritis to low back pain) could be shown. Nearly all studied balneotherapeutic modalities were applied as bathing cures. Only in one study peloid therapy was applied. Balneotherapeutic therapy was applied in a modern and traditional way, and both open and stationary spa therapy forms were used at the same time. The review has shown the effectiveness of the investigated spa therapy and balneotherapy forms. It could be concluded that nearly all forms of spa therapy and balneotherapy used for the treatment of rheumatic diseases in Turkey are effective. A definitive conclusion, however, is not possible because of the heterogeneity of the study designs, methodological flaws, and the publication bias. In future good quality randomized controlled trials are needed. Copyright 2004 S. Karger GmbH, Freiburg

BIOREACTOR LANDFILL DESIGN

EPA Science Inventory

Modern landfill design entails many elements including foundations, liner systems, leachate collection systems, stormwater control systems, slope stability considerations, leachate management systems, gas extraction systems, and capping and closure. The use of bioreactor technolo...

Design and Fabrication of DebriSat - A Representative LEO Satellite for Improvements to Standard Satellite Breakup Models

NASA Technical Reports Server (NTRS)

Clark, S.; Dietrich, A.; Fitz-Coy, N.; Weremeyer, M.; Liou, J.-C.

2012-01-01

This paper discusses the design and fabrication of DebriSat, a 50 kg satellite developed to be representative of a modern low Earth orbit satellite in terms of its components, materials used, and fabrication procedures. DebriSat will be the target of a future hypervelocity impact experiment to determine the physical characteristics of debris generated after an on-orbit collision of a modern LEO satellite. The major ground-based satellite impact experiment used by DoD and NASA in their development of satellite breakup models was SOCIT, conducted in 1992. The target used for that experiment was a Navy transit satellite (40 cm, 35 kg) fabricated in the 1960's. Modern satellites are very different in materials and construction techniques than those built 40 years ago. Therefore, there is a need to conduct a similar experiment using a modern target satellite to improve the fidelity of the satellite breakup models. To ensure that DebriSat is truly representative of typical LEO missions, a comprehensive study of historical LEO satellite designs and missions within the past 15 years for satellites ranging from 1 kg to 5000 kg was conducted. This study identified modern trends in hardware, material, and construction practices utilized in recent LEO missions. Although DebriSat is an engineering model, specific attention is placed on the quality, type, and quantity of the materials used in its fabrication to ensure the integrity of the outcome. With the exception of software, all other aspects of the satellite s design, fabrication, and assembly integration and testing will be as rigorous as that of an actual flight vehicle. For example, to simulate survivability of launch loads, DebriSat will be subjected to a vibration test. As well, the satellite will undergo thermal vacuum tests to verify that the components and overall systems meet typical environmental standards. Proper assembly and integration techniques will involve comprehensive joint analysis, including the precise torqueing of fasteners and thread locking. Finally, the implementation of process documentation and verification procedures is discussed to provide a comprehensive overview of the design and fabrication of this representative LEO satellite.

Power Systems Design and Studies | Grid Modernization | NREL

Science.gov Websites

Design and Studies Power Systems Design and Studies NREL develops new tools, algorithms, and market design and performance evaluations; and planning, operations, and protection studies. Photo of two researchers looking at a screen showing a distribution grid map Current design and planning tools for the

Problems of Research, Projects and Mechanisms for Their Implementation in Chelyabinsk City Agglomeration

NASA Astrophysics Data System (ADS)

Bolshakov, V. V.

2017-11-01

The article analyzes the research and design methods of urban agglomerations in the context of the Chelyabinsk agglomeration from the point of view of correctness, objectivity and consistency of the results obtained. The completed and approved project of the Chelyabinsk agglomeration is analysed to provide architectural and planning solutions for sustainable social and economic development according to the theories that have been formed to date. The possibility of effectuation and implementation of the approved project of the Chelyabinsk agglomeration taking in account existing specific natural, historical and socio-economic factors characteristic for the territory under consideration is examined. The authors draw the conclusions the project of the Chelyabinsk agglomeration has been developed in line with the town-planning solutions that do not reflect modern approaches based on the competitive advantages of territories and do not form a space providing transition to a modernized and innovative economy. Specific town-planning decisions have a weak justification and an undeveloped methodology for pre-project analysis and methodology for designing urban agglomerations because of absence of a full study of the phenomenon of urban agglomeration and processes occurring in it today. It is necessary to continue research in the field of development of the Chelyabinsk agglomeration with the use of a logical and objective methodology to analyze the territory and design which can lead to the formation of an urban-planning information model that reflects all the system processes and allows for predicting project solutions.

Beam by design: Laser manipulation of electrons in modern accelerators

NASA Astrophysics Data System (ADS)

Hemsing, Erik; Stupakov, Gennady; Xiang, Dao; Zholents, Alexander

2014-07-01

Accelerator-based light sources such as storage rings and free-electron lasers use relativistic electron beams to produce intense radiation over a wide spectral range for fundamental research in physics, chemistry, materials science, biology, and medicine. More than a dozen such sources operate worldwide, and new sources are being built to deliver radiation that meets with the ever-increasing sophistication and depth of new research. Even so, conventional accelerator techniques often cannot keep pace with new demands and, thus, new approaches continue to emerge. In this article, a variety of recently developed and promising techniques that rely on lasers to manipulate and rearrange the electron distribution in order to tailor the properties of the radiation are reviewed. Basic theories of electron-laser interactions, techniques to create microstructures and nanostructures in electron beams, and techniques to produce radiation with customizable waveforms are reviewed. An overview of laser-based techniques for the generation of fully coherent x rays, mode-locked x-ray pulse trains, light with orbital angular momentum, and attosecond or even zeptosecond long coherent pulses in free-electron lasers is presented. Several methods to generate femtosecond pulses in storage rings are also discussed. Additionally, various schemes designed to enhance the performance of light sources through precision beam preparation including beam conditioning, laser heating, emittance exchange, and various laser-based diagnostics are described. Together these techniques represent a new emerging concept of "beam by design" in modern accelerators, which is the primary focus of this article.

Visual Aspects of the Electric Environment. NECA Electrical Design Guidelines.

ERIC Educational Resources Information Center

National Electrical Contractors Association, Washington, DC.

New design opportunities afforded by modern high-intensity light sources, and the many ways of integrating package air-conditioners with the design of buildings, are discussed. A guide to unitary air-conditioners and heat pumps is included. (RK)

Modern Vernacular.

ERIC Educational Resources Information Center

Taggart, Jim

2002-01-01

Describes the design of the Nicola Valley Institute of Technology in British Columbia, including the educational context and design goals. Includes information on architects, consultants, and cost, as well as floor plans and photographs. Discusses how the design for this First Nations school blends aboriginal constructs and…

Design and application of star map simulation system for star sensors

NASA Astrophysics Data System (ADS)

Wu, Feng; Shen, Weimin; Zhu, Xifang; Chen, Yuheng; Xu, Qinquan

2013-12-01

Modern star sensors are powerful to measure attitude automatically which assure a perfect performance of spacecrafts. They achieve very accurate attitudes by applying algorithms to process star maps obtained by the star camera mounted on them. Therefore, star maps play an important role in designing star cameras and developing procession algorithms. Furthermore, star maps supply significant supports to exam the performance of star sensors completely before their launch. However, it is not always convenient to supply abundant star maps by taking pictures of the sky. Thus, star map simulation with the aid of computer attracts a lot of interests by virtue of its low price and good convenience. A method to simulate star maps by programming and extending the function of the optical design program ZEMAX is proposed. The star map simulation system is established. Firstly, based on analyzing the working procedures of star sensors to measure attitudes and the basic method to design optical system by ZEMAX, the principle of simulating star sensor imaging is given out in detail. The theory about adding false stars and noises, and outputting maps is discussed and the corresponding approaches are proposed. Then, by external programming, the star map simulation program is designed and produced. Its user interference and operation are introduced. Applications of star map simulation method in evaluating optical system, star image extraction algorithm and star identification algorithm, and calibrating system errors are presented completely. It was proved that the proposed simulation method provides magnificent supports to the study on star sensors, and improves the performance of star sensors efficiently.

Factors influencing contraceptive use and non-use among women of advanced reproductive age in Nigeria.

PubMed

Solanke, Bola Lukman

2017-01-07

Factors influencing contraceptive use and non-use among women of advanced reproductive age have been insufficiently researched in Nigeria. This study examines factors influencing contraceptive use and non-use among women of advanced reproductive age in Nigeria. Secondary data were pooled and extracted from 2008 and 2013 Nigeria Demographic and Health Surveys (NDHS). The weighted sample size was 14,450 women of advanced reproductive age. The dependent variable was current contraceptive use. The explanatory variables were selected socio-demographic characteristics and three control variables. Analyses were performed using Stata version 12. Multinomial logistic regression was applied in four models. Majority of the respondents are not using any method of contraceptive; the expected risk of using modern contraceptive relative to traditional method reduces by a factor of 0.676 for multiparous women (rrr = 0.676; CI: 0.464-0.985); the expected risk of using modern contraceptive relative to traditional method reduces by a factor of 0.611 for women who want more children (rrr = 0.611; CI: 0.493-0.757); the relative risk for using modern contraceptive relative to traditional method increases by a factor of 1.637 as maternal education reaches secondary education (rrr = 1.637; CI: 1.173-2.285); the relative risk for using modern contraceptive relative to traditional method increases by a factor of 1.726 for women in richest households (rrr = 1.726; CI: 1.038-2.871); and the expected risk of using modern contraceptive relative to traditional method increases by a factor of 1.250 for southern women (rrr = 1.250; CI: 1.200-1.818). Socio-demographic characteristics exert more influence on non-use than modern contraceptive use. The scope, content and coverage of existing BCC messages should be extended to cover the contraceptive needs and challenges of women of advanced reproductive age in the country.

Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production.

PubMed

Oyarzún, Patricio; Kobe, Bostjan

2016-03-03

Novel vaccination approaches based on rational design of B- and T-cell epitopes - epitope-based vaccines - are making progress in the clinical trial pipeline. The epitope-focused recombinant protein-based malaria vaccine (termed RTS,S) is a next-generation approach that successfully reached phase-III trials, and will potentially become the first commercial vaccine against a human parasitic disease. Progress made on methods such as recombinant DNA technology, advanced cell-culture techniques, immunoinformatics and rational design of immunogens are driving the development of these novel concepts. Synthetic recombinant proteins comprising both B- and T-cell epitopes can be efficiently produced through modern biotechnology and bioprocessing methods, and can enable the induction of large repertoires of immune specificities. In particular, the inclusion of appropriate CD4+ T-cell epitopes is increasingly considered a key vaccine component to elicit robust immune responses, as suggested by results coming from HIV-1 clinical trials. In silico strategies for vaccine design are under active development to address genetic variation in pathogens and several broadly protective "universal" influenza and HIV-1 vaccines are currently at different stages of clinical trials. Other methods focus on improving population coverage in target populations by rationally considering specificity and prevalence of the HLA proteins, though a proof-of-concept in humans has not been demonstrated yet. Overall, we expect immunoinformatics and bioprocessing methods to become a central part of the next-generation epitope-based vaccine development and production process.

Critique of a practice-based pilot study in chiropractic practices in Western Australia.

PubMed

Amorin-Woods, Lyndon G; Parkin-Smith, Gregory F; Nedkoff, Lee; Fisher, Colleen

2016-01-01

Practice-based data collection can offer insight into the nature of chiropractic practice and contribute to resolving the conundrum of the chiropractic profession's role in contemporary healthcare, subsequently informing care service policy. However, there is little formal data available about chiropractic practice to inform decision-makers about the nature and role of chiropractic within the context of a modern multidisciplinary healthcare context in Australia, particularly at a local and regional level. This was a mixed-methods data transformation model (qualitative to quantitative) pilot study the purpose of which was to provide a critique of the research design and collect data from a selected sample of chiropractic practices in Western Australia, with a view to offer recommendations related to the design, feasibility and implementation of a future confirmatory study. A narrative critique of the research methods of this pilot study is offered in this paper covering: (a) practice and patient recruitment, (b) enrollment of patients, (c) data collection methods, (d) acceptability of the study methods, (e) sample size calculations, and (f) design critique. The result of this critique provides a sensible sample size estimate and recommendations as to the design and implementation of a future confirmatory study. Furthermore, we believe that a confirmatory study is not only feasible, but indeed necessary, with a view to offer meaningful insight into chiropractic practice in Western Australia. ACTRN12616000434493 Australian New Zealand Clinical Trials Registry (ANZCTR). Registered 5 April 2016. First participant enrolled 01 July 2014, retrospectively registered.

Applicability of PM3 to transphosphorylation reaction path: Toward designing a minimal ribozyme

NASA Technical Reports Server (NTRS)

Manchester, John I.; Shibata, Masayuki; Setlik, Robert F.; Ornstein, Rick L.; Rein, Robert

1993-01-01

A growing body of evidence shows that RNA can catalyze many of the reactions necessary both for replication of genetic material and the possible transition into the modern protein-based world. However, contemporary ribozymes are too large to have self-assembled from a prebiotic oligonucleotide pool. Still, it is likely that the major features of the earliest ribozymes have been preserved as molecular fossils in the catalytic RNA of today. Therefore, the search for a minimal ribozyme has been aimed at finding the necessary structural features of a modern ribozyme (Beaudry and Joyce, 1990). Both a three-dimensional model and quantum chemical calculations are required to quantitatively determine the effects of structural features of the ribozyme on the reaction it catalyzes. Using this model, quantum chemical calculations must be performed to determine quantitatively the effects of structural features on catalysis. Previous studies of the reaction path have been conducted at the ab initio level, but these methods are limited to small models due to enormous computational requirements. Semiempirical methods have been applied to large systems in the past; however, the accuracy of these methods depends largely on a simple model of the ribozyme-catalyzed reaction, or hydrolysis of phosphoric acid. We find that the results are qualitatively similar to ab initio results using large basis sets. Therefore, PM3 is suitable for studying the reaction path of the ribozyme-catalyzed reaction.

Twilight of dawn or of evening? A century of research methods in the Journal of Applied Psychology.

PubMed

Cortina, Jose M; Aguinis, Herman; DeShon, Richard P

2017-03-01

We offer a critical review and synthesis of research methods in the first century of the Journal of Applied Psychology. We divide the chronology into 6 periods. The first emphasizes the first few issues of the journal, which, in many ways, set us on a methodological course that we sail to this day, and then takes us through the mid-1920s. The second is the period through World War II, in which we see the roots of modern methodological concepts and techniques, including a transition from a discovery orientation to a hypotheticodeductive model orientation. The third takes us through roughly 1970, a period in which many of our modern-day practices were formed, such as reliance on null hypothesis significance testing. The fourth, from 1970 through 1989, sees an emphasis on the development of measures of critical constructs. The fifth takes us into the present, which is marked by greater plurality regarding data-analytic approaches. Finally, we offer a glimpse of possible and, from our perspective, desirable futures regarding research methods. Specifically, we highlight the need to conduct replications; study the exceptional and not just the average; improve the quality of the review process, particularly regarding methodological issues; emphasize design and measurement issues; and build and test more specific theories. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Power Market Design | Grid Modernization | NREL

Science.gov Websites

Power Market Design Power Market Design NREL researchers are developing a modeling platform to test (a commercial electricity production simulation model) and FESTIV (the NREL-developed Flexible Energy consisting of researchers in power systems and economics Projects Grid Market Design Project The objective of

Aerospace engineering design by systematic decomposition and multilevel optimization

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, J.; Giles, G. L.; Barthelemy, J.-F. M.

1984-01-01

This paper describes a method for systematic analysis and optimization of large engineering systems, e.g., aircraft, by decomposition of a large task into a set of smaller, self-contained subtasks that can be solved concurrently. The subtasks may be arranged in many hierarchical levels with the assembled system at the top level. Analyses are carried out in each subtask using inputs received from other subtasks, and are followed by optimizations carried out from the bottom up. Each optimization at the lower levels is augmented by analysis of its sensitivity to the inputs received from other subtasks to account for the couplings among the subtasks in a formal manner. The analysis and optimization operations alternate iteratively until they converge to a system design whose performance is maximized with all constraints satisfied. The method, which is still under development, is tentatively validated by test cases in structural applications and an aircraft configuration optimization. It is pointed out that the method is intended to be compatible with the typical engineering organization and the modern technology of distributed computing.

Preliminary aerodynamic design considerations for advanced laminar flow aircraft configurations

NASA Technical Reports Server (NTRS)

Johnson, Joseph L., Jr.; Yip, Long P.; Jordan, Frank L., Jr.

1986-01-01

Modern composite manufacturing methods have provided the opportunity for smooth surfaces that can sustain large regions of natural laminar flow (NLF) boundary layer behavior and have stimulated interest in developing advanced NLF airfoils and improved aircraft designs. Some of the preliminary results obtained in exploratory research investigations on advanced aircraft configurations at the NASA Langley Research Center are discussed. Results of the initial studies have shown that the aerodynamic effects of configuration variables such as canard/wing arrangements, airfoils, and pusher-type and tractor-type propeller installations can be particularly significant at high angles of attack. Flow field interactions between aircraft components were shown to produce undesirable aerodynamic effects on a wing behind a heavily loaded canard, and the use of properly designed wing leading-edge modifications, such as a leading-edge droop, offset the undesirable aerodynamic effects by delaying wing stall and providing increased stall/spin resistance with minimum degradation of laminar flow behavior.

Development of computer-aided design system of elastic sensitive elements of automatic metering devices

NASA Astrophysics Data System (ADS)

Kalinkina, M. E.; Kozlov, A. S.; Labkovskaia, R. I.; Pirozhnikova, O. I.; Tkalich, V. L.; Shmakov, N. A.

2018-05-01

The object of research is the element base of devices of control and automation systems, including in its composition annular elastic sensitive elements, methods of their modeling, calculation algorithms and software complexes for automation of their design processes. The article is devoted to the development of the computer-aided design system of elastic sensitive elements used in weight- and force-measuring automation devices. Based on the mathematical modeling of deformation processes in a solid, as well as the results of static and dynamic analysis, the calculation of elastic elements is given using the capabilities of modern software systems based on numerical simulation. In the course of the simulation, the model was a divided hexagonal grid of finite elements with a maximum size not exceeding 2.5 mm. The results of modal and dynamic analysis are presented in this article.

The emergence of modern statistics in agricultural science: analysis of variance, experimental design and the reshaping of research at Rothamsted Experimental Station, 1919-1933.

PubMed

Parolini, Giuditta

2015-01-01

During the twentieth century statistical methods have transformed research in the experimental and social sciences. Qualitative evidence has largely been replaced by quantitative results and the tools of statistical inference have helped foster a new ideal of objectivity in scientific knowledge. The paper will investigate this transformation by considering the genesis of analysis of variance and experimental design, statistical methods nowadays taught in every elementary course of statistics for the experimental and social sciences. These methods were developed by the mathematician and geneticist R. A. Fisher during the 1920s, while he was working at Rothamsted Experimental Station, where agricultural research was in turn reshaped by Fisher's methods. Analysis of variance and experimental design required new practices and instruments in field and laboratory research, and imposed a redistribution of expertise among statisticians, experimental scientists and the farm staff. On the other hand the use of statistical methods in agricultural science called for a systematization of information management and made computing an activity integral to the experimental research done at Rothamsted, permanently integrating the statisticians' tools and expertise into the station research programme. Fisher's statistical methods did not remain confined within agricultural research and by the end of the 1950s they had come to stay in psychology, sociology, education, chemistry, medicine, engineering, economics, quality control, just to mention a few of the disciplines which adopted them.

Barriers of modern contraceptive practices among Asian women: a mini literature review.

PubMed

Najafi-Sharjabad, Fatemeh; Zainiyah Syed Yahya, Sharifah; Abdul Rahman, Hejar; Hanafiah Juni, Muhamad; Abdul Manaf, Rosliza

2013-07-22

Family planning has been cited as essential to the achievement of Millennium Development Goals (MDG). Family planning has a direct impact on women's health and consequence of each pregnancy. The use of modern contraception among Asian women is less than global average. In Asia a majority of unintended pregnancies are due to using traditional contraceptive or no methods which lead to induced unsafe abortion. Cultural attitudes, lack of knowledge of methods and reproduction, socio demographic factors, and health service barriers are the main obstacles to modern contraceptive practice among Asian women. Culturally sensitive family planning program, reforming health system, and reproductive health education through mass media to create awareness of the benefits of planned parenthood are effective strategies to improve modern contraceptive practice among Asian women.

Barriers of Modern Contraceptive Practices among Asian Women: A Mini Literature Review

PubMed Central

Najafi-Sharjabad, Fatemeh; Syed Yahya, Sharifah Zainiyah; Rahman, Hejar Abdul; Hanafiah, Muhamad; Abdul Manaf, Rosliza

2013-01-01

Family planning has been cited as essential to the achievement of Millennium Development Goals (MDG). Family planning has a direct impact on women's health and consequence of each pregnancy. The use of modern contraception among Asian women is less than global average. In Asia a majority of unintended pregnancies are due to using traditional contraceptive or no methods which lead to induced unsafe abortion. Cultural attitudes, lack of knowledge of methods and reproduction, socio demographic factors, and health service barriers are the main obstacles to modern contraceptive practice among Asian women. Culturally sensitive family planning program, reforming health system, and reproductive health education through mass media to create awareness of the benefits of planned parenthood are effective strategies to improve modern contraceptive practice among Asian women. PMID:23985120

Case for a field-programmable gate array multicore hybrid machine for an image-processing application

NASA Astrophysics Data System (ADS)

Rakvic, Ryan N.; Ives, Robert W.; Lira, Javier; Molina, Carlos

2011-01-01

General purpose computer designers have recently begun adding cores to their processors in order to increase performance. For example, Intel has adopted a homogeneous quad-core processor as a base for general purpose computing. PlayStation3 (PS3) game consoles contain a multicore heterogeneous processor known as the Cell, which is designed to perform complex image processing algorithms at a high level. Can modern image-processing algorithms utilize these additional cores? On the other hand, modern advancements in configurable hardware, most notably field-programmable gate arrays (FPGAs) have created an interesting question for general purpose computer designers. Is there a reason to combine FPGAs with multicore processors to create an FPGA multicore hybrid general purpose computer? Iris matching, a repeatedly executed portion of a modern iris-recognition algorithm, is parallelized on an Intel-based homogeneous multicore Xeon system, a heterogeneous multicore Cell system, and an FPGA multicore hybrid system. Surprisingly, the cheaper PS3 slightly outperforms the Intel-based multicore on a core-for-core basis. However, both multicore systems are beaten by the FPGA multicore hybrid system by >50%.

Regional trends in the use of short-acting and long-acting contraception accessed through the private and public sectors.

PubMed

Ugaz, Jorge I; Chatterji, Minki; Gribble, James N; Mitchell, Susan

2015-08-01

To examine trends in the source of modern contraception (public versus private sector); method choice (long-acting or permanent methods versus short-acting methods); and method and source combined. A retrospective analysis was conducted using data collected by national Demographic and Health Surveys and Reproductive Health Surveys during the period 1992-2012. The dataset included 18 low-income countries in Sub-Saharan Africa, 10 from Latin America and the Caribbean (LAC), and 8 from Asia. A substantial proportion-between 40% and 49%-of modern contraceptive users relied on the private sector in Asia and LAC in the last 20years, yet the proportion has been smaller in Sub-Saharan Africa, between 27% and 30%. Increased use of short-acting methods from both public and private sectors has driven the rise in contraceptive prevalence in Asia and LAC. Similarly, increased contraceptive prevalence in Sub-Saharan Africa reflected the increased use of short-acting methods obtained mainly through the public sector, with only limited use of long-acting or permanent methods through the private sector. The private sector has played a key role in the increase of modern CPR and the provision of modern contraceptives around the world, providing almost half of them in low-income countries. Yet, such increase was driven primarily by a more substantial role in the provision of short-acting methods than long acting and permanent methods. Crown Copyright © 2015. Published by Elsevier Ireland Ltd. All rights reserved.

Toward a Foundation of Library Philosophy: Comparing the Medieval and Modern Library.

ERIC Educational Resources Information Center

Buschman, John

Through a comparison of the historical perspectives of medieval and modern libraries, this paper is designed to clarify the purpose and goals of the library, and to promote a public and intellectual debate to guide future developments. The Middle Ages were chosen because libraries possessed an importance and centrality to learning, civilization,…

Modern energy efficient technologies of high-rise construction

NASA Astrophysics Data System (ADS)

Lukmanova, Inessa; Golov, Roman

2018-03-01

The paper analyzes modern energy-efficient technologies, both being applied, and only introduced into the application in the construction of high-rise residential buildings. All technologies are systematized by the authors as part of a unified model of "Arrows of Energy-Efficient Technologies", which imply performing energy-saving measures in the design, construction and operation of buildings.

Accounting Capstone Course Design: Using the Internet to Modernize a Graduate Accounting Capstone Course

ERIC Educational Resources Information Center

Bloom, Diane S.; Ehoff, Clemense, Jr.

2012-01-01

This second paper describes how the Internet was used to modernize a graduate accounting capstone course to enhance student interest and learning, and is an extension of an earlier paper that examined a similar approach with an undergraduate accounting capstone course. Course content was developed from contemporary issues and cases obtained from…

New Perspectives on Teaching and Learning Modern Languages. Modern Languages in Practice, 13.

ERIC Educational Resources Information Center

Green, Simon, Ed.

This book comprises a series of newly commissioned chapters designed to stimulate debate about what kind of language-teaching is appropriate for the new millennium, what skills learners will need to cope with the technological and linguistic demands, and how the two can be synthesized. Collectively, the contributors seek a convergence of views…

Effects of a Science Education Module on Attitudes towards Modern Biotechnology of Secondary School Students

ERIC Educational Resources Information Center

Klop, Tanja; Severiens, Sabine E.; Knippels, Marie-Christine P. J.; van Mil, Marc H. W.; Ten Dam, Geert T. M.

2010-01-01

This article evaluated the impact of a four-lesson science module on the attitudes of secondary school students. This science module (on cancer and modern biotechnology) utilises several design principles, related to a social constructivist perspective on learning. The expectation was that the module would help students become more articulate in…

Syllabus for Use in Modern Chinese History.

ERIC Educational Resources Information Center

Husum, Carol

This syllabus, for use in a one semester course on the history of modern China, covers the period from the Manchu domination in 1644 to the present. The course is designed to create an interest in China, emphasizing the social and cultural aspects of history, as well as the political and economic dimensions. A narrative summary of course content…

The application of modern methods of biomechanics to the evaluation of jumping performance in ancient Greece.

PubMed

Ward-Smith, A J

1995-06-01

Modern methods of biomechanics are applied to examine some of the outstanding feats of jumping that have been reported in the literature from classical times. It is concluded that these feats could not have been achieved using the current long-jump prescription, with the take-off and landing areas in the same horizontal plane. A possible explanation is that the landing area was some 5.5 m or more below the take-off area. Alternatively, and more plausibly, the jump could have been similar to the modern triple jump.

Hypothesis Testing, "p" Values, Confidence Intervals, Measures of Effect Size, and Bayesian Methods in Light of Modern Robust Techniques

ERIC Educational Resources Information Center

Wilcox, Rand R.; Serang, Sarfaraz

2017-01-01

The article provides perspectives on p values, null hypothesis testing, and alternative techniques in light of modern robust statistical methods. Null hypothesis testing and "p" values can provide useful information provided they are interpreted in a sound manner, which includes taking into account insights and advances that have…

Reconstructing metastatic seeding patterns of human cancers

PubMed Central

Reiter, Johannes G.; Makohon-Moore, Alvin P.; Gerold, Jeffrey M.; Bozic, Ivana; Chatterjee, Krishnendu; Iacobuzio-Donahue, Christine A.; Vogelstein, Bert; Nowak, Martin A.

2017-01-01

Reconstructing the evolutionary history of metastases is critical for understanding their basic biological principles and has profound clinical implications. Genome-wide sequencing data has enabled modern phylogenomic methods to accurately dissect subclones and their phylogenies from noisy and impure bulk tumour samples at unprecedented depth. However, existing methods are not designed to infer metastatic seeding patterns. Here we develop a tool, called Treeomics, to reconstruct the phylogeny of metastases and map subclones to their anatomic locations. Treeomics infers comprehensive seeding patterns for pancreatic, ovarian, and prostate cancers. Moreover, Treeomics correctly disambiguates true seeding patterns from sequencing artifacts; 7% of variants were misclassified by conventional statistical methods. These artifacts can skew phylogenies by creating illusory tumour heterogeneity among distinct samples. In silico benchmarking on simulated tumour phylogenies across a wide range of sample purities (15–95%) and sequencing depths (25-800 × ) demonstrates the accuracy of Treeomics compared with existing methods. PMID:28139641

The Salman Mosque: Achmad Noe’man’s Critique of Indonesian Conventional Mosque Architecture

NASA Astrophysics Data System (ADS)

Holik, A. A. R.; Aryanti, T.

2017-03-01

The Salman Mosque, designed by Achmad Noe’man, was a striking Islamic architectural design in the 1960s when it was built. Unlike the conventional mosques, particularly in Indonesia, it has no dome. Instead, the roof was made of prestressed concrete and resembles a canoe. Using data drawn from field observations, this paper explores the architectural characteristics of the Salman Mosque as a product of Modern architecture. It argues that the domeless mosque, the simple minaret, the wooden wall panels and floor, the women’s balcony, and the roof demonstrate architectural modernism, as opposed to the conventional mosque typology that flourished in Indonesia at the time. This paper further argues that the Salman Mosque is Noe’man’s critique of the Indonesian conventional mosque architecture. It concludes that the architectural features of the Salman Mosque reflects Noe’man’s modern vision of Islam and Islamic architecture.

Periodic control of the individual-blade-control helicopter rotor

NASA Technical Reports Server (NTRS)

Mckillip, R. M., Jr.

1985-01-01

This paper describes the results of an investigation into methods of controller design for linear periodic systems utilizing an extension of modern control methods. Trends present in the selection of various cost functions are outlined, and closed-loop controller results are demonstrated for two cases: first, on an analog computer simulation of the rigid out of plane flapping dynamics of a single rotor blade, and second, on a 4 ft diameter single-bladed model helicopter rotor in the MIT 5 x 7 subsonic wind tunnel, both for various high levels of advance ratio. It is shown that modal control using the IBC concept is possible over a large range of advance ratios with only a modest amount of computational power required.

Application of step-frequency radars in medicine

NASA Astrophysics Data System (ADS)

Anishchenko, L.; Alekhin, M.; Tataraidze, A.; Ivashov, S.; Bugaev, Alexander S.; Soldovieri, F.

2014-05-01

The paper summarizes results of step-frequency radars application in medicine. Remote and non-contact control of physiological parameters with modern bioradars provides a wide range of possibilities for non-contact remote monitoring of a human psycho-emotional state and physiological condition. The paper provides information about technical characteristics of bioradars designed at Bauman Moscow State Technical University and experiments using them. Results of verification experiment showed that bioradars of BioRASCAN type may be used for simultaneous remote measurements of breathing and heart rate parameters. In addition, bioradar assisted experiments for detecting of different sleep disorders are described. Their results proved that method of bioradiolocation allows correct estimation of obstructive sleep apnea severity compared to the polysomnography method, which satisfies standard medical recommendations.

[Advantages and disadvantages of femtosecond laser assisted LASIK and SMILE].

PubMed

Zhang, F J; Sun, M S

2018-01-11

With the development of excimer laser and femtosecond laser equipment, application of diversified and customized surgical decision in modern corneal refractive surgery has been an inevitable trend. However, how to make a personalized decision with an accurate surgical design to achieve better visual quality becomes the main focus in clinical applications. Small-incision lenticule extraction (SMILE) and femtosecond assisted laser in situ keratomileusis (FS-LASIK) have been commonly acknowledged as the mainstream of corneal refractive surgery for ametropia correction nowadays. Both methods have been verified by clinical practice for many years. This article compares and elaborates the different characteristics with advantages and disadvantages of the two methods so as to provide some reasonable treatment options for refractive surgery. (Chin J Ophthalmol, 2018, 54: 7-10) .

Designing Hysteresis with Dipolar Chains

NASA Astrophysics Data System (ADS)

Concha, Andrés; Aguayo, David; Mellado, Paula

2018-04-01

Materials that have hysteretic response to an external field are essential in modern information storage and processing technologies. A myriad of magnetization curves of several natural and artificial materials have previously been measured and each has found a particular mechanism that accounts for it. However, a phenomenological model that captures all the hysteresis loops and at the same time provides a simple way to design the magnetic response of a material while remaining minimal is missing. Here, we propose and experimentally demonstrate an elementary method to engineer hysteresis loops in metamaterials built out of dipolar chains. We show that by tuning the interactions of the system and its geometry we can shape the hysteresis loop which allows for the design of the softness of a magnetic material at will. Additionally, this mechanism allows for the control of the number of loops aimed to realize multiple-valued logic technologies. Our findings pave the way for the rational design of hysteretical responses in a variety of physical systems such as dipolar cold atoms, ferroelectrics, or artificial magnetic lattices, among others.

Trajectory Optimization for Missions to Small Bodies with a Focus on Scientific Merit.

PubMed

Englander, Jacob A; Vavrina, Matthew A; Lim, Lucy F; McFadden, Lucy A; Rhoden, Alyssa R; Noll, Keith S

2017-01-01

Trajectory design for missions to small bodies is tightly coupled both with the selection of targets for a mission and with the choice of spacecraft power, propulsion, and other hardware. Traditional methods of trajectory optimization have focused on finding the optimal trajectory for an a priori selection of destinations and spacecraft parameters. Recent research has expanded the field of trajectory optimization to multidisciplinary systems optimization that includes spacecraft parameters. The logical next step is to extend the optimization process to include target selection based not only on engineering figures of merit but also scientific value. This paper presents a new technique to solve the multidisciplinary mission optimization problem for small-bodies missions, including classical trajectory design, the choice of spacecraft power and propulsion systems, and also the scientific value of the targets. This technique, when combined with modern parallel computers, enables a holistic view of the small body mission design process that previously required iteration among several different design processes.

Designing Hysteresis with Dipolar Chains.

PubMed

Concha, Andrés; Aguayo, David; Mellado, Paula

2018-04-13

Materials that have hysteretic response to an external field are essential in modern information storage and processing technologies. A myriad of magnetization curves of several natural and artificial materials have previously been measured and each has found a particular mechanism that accounts for it. However, a phenomenological model that captures all the hysteresis loops and at the same time provides a simple way to design the magnetic response of a material while remaining minimal is missing. Here, we propose and experimentally demonstrate an elementary method to engineer hysteresis loops in metamaterials built out of dipolar chains. We show that by tuning the interactions of the system and its geometry we can shape the hysteresis loop which allows for the design of the softness of a magnetic material at will. Additionally, this mechanism allows for the control of the number of loops aimed to realize multiple-valued logic technologies. Our findings pave the way for the rational design of hysteretical responses in a variety of physical systems such as dipolar cold atoms, ferroelectrics, or artificial magnetic lattices, among others.

Sustainable Rest Area Design and Operations

DOT National Transportation Integrated Search

2017-10-01

One way in which State Departments of Transportation (DOTs) can modernize their rest areas while reducing operations and maintenance costs is by incorporating sustainable practices into rest area design and operations. Sustainability practices that D...

Formation of costs of high-rise objects of housing and civil purpose based on enlarged norms

NASA Astrophysics Data System (ADS)

Vorotyntseva, Anna; Ovsiannikov, Andrei; Bolgov, Vladimir

2018-03-01

When determining the cost of capital construction objects, for purposes of pre-design workings out and purposes of initial maximum initial price determination on tenders, construction price norms are used (CPNs). Modern CPNs are not designed to determine the value of high-rise buildings. It is necessary to adapt modern CPNs to get opportunity for the possibility to take into account special cost factors in determining the cost of high-rise buildings. The main ways can be: selection of new representative objects or application of additional correction factors.

Informatics for the Modern Intensive Care Unit.

PubMed

Anderson, Diana C; Jackson, Ashley A; Halpern, Neil A

Advanced informatics systems can help improve health care delivery and the environment of care for critically ill patients. However, identifying, testing, and deploying advanced informatics systems can be quite challenging. These processes often require involvement from a collaborative group of health care professionals of varied disciplines with knowledge of the complexities related to designing the modern and "smart" intensive care unit (ICU). In this article, we explore the connectivity environment within the ICU, middleware technologies to address a host of patient care initiatives, and the core informatics concepts necessary for both the design and implementation of advanced informatics systems.

Chemical Markup, XML and the World-Wide Web. 8. Polymer Markup Language.

PubMed

Adams, Nico; Winter, Jerry; Murray-Rust, Peter; Rzepa, Henry S

2008-11-01

Polymers are among the most important classes of materials but are only inadequately supported by modern informatics. The paper discusses the reasons why polymer informatics is considerably more challenging than small molecule informatics and develops a vision for the computer-aided design of polymers, based on modern semantic web technologies. The paper then discusses the development of Polymer Markup Language (PML). PML is an extensible language, designed to support the (structural) representation of polymers and polymer-related information. PML closely interoperates with Chemical Markup Language (CML) and overcomes a number of the previously identified challenges.

Simple, stable and reliable modeling of gas properties of organic working fluids in aerodynamic designs of turbomachinery for ORC and VCC

NASA Astrophysics Data System (ADS)

Kawakubo, T.

2016-05-01

A simple, stable and reliable modeling of the real gas nature of the working fluid is required for the aerodesigns of the turbine in the Organic Rankine Cycle and of the compressor in the Vapor Compression Cycle. Although many modern Computational Fluid Dynamics tools are capable of incorporating real gas models, simulations with such a gas model tend to be more time-consuming than those with a perfect gas model and even can be unstable due to the simulation near the saturation boundary. Thus a perfect gas approximation is still an attractive option to stably and swiftly conduct a design simulation. In this paper, an effective method of the CFD simulation with a perfect gas approximation is discussed. A method of representing the performance of the centrifugal compressor or the radial-inflow turbine by means of each set of non-dimensional performance parameters and translating the fictitious perfect gas result to the actual real gas performance is presented.

Robust Control for Microgravity Vibration Isolation using Fixed Order, Mixed H2/Mu Design

NASA Technical Reports Server (NTRS)

Whorton, Mark

2003-01-01

Many space-science experiments need an active isolation system to provide a sufficiently quiescent microgravity environment. Modern control methods provide the potential for both high-performance and robust stability in the presence of parametric uncertainties that are characteristic of microgravity vibration isolation systems. While H2 and H(infinity) methods are well established, neither provides the levels of attenuation performance and robust stability in a compensator with low order. Mixed H2/H(infinity), controllers provide a means for maximizing robust stability for a given level of mean-square nominal performance while directly optimizing for controller order constraints. This paper demonstrates the benefit of mixed norm design from the perspective of robustness to parametric uncertainties and controller order for microgravity vibration isolation. A nominal performance metric analogous to the mu measure, for robust stability assessment is also introduced in order to define an acceptable trade space from which different control methodologies can be compared.

Multivariable feedback design - Concepts for a classical/modern synthesis

NASA Technical Reports Server (NTRS)

Doyle, J. C.; Stein, G.

1981-01-01

This paper presents a practical design perspective on multivariable feedback control problems. It reviews the basic issue - feedback design in the face of uncertainties - and generalizes known single-input, single-output (SISO) statements and constraints of the design problem to multiinput, multioutput (MIMO) cases. Two major MIMO design approaches are then evaluated in the context of these results.

The Polyfunctionality of Design Language in the Education System of the Design-Student

ERIC Educational Resources Information Center

Lazutina, Tatiana Vladimirovna; Lazutin, Nicolay Konstantinovich

2016-01-01

This research work is devoted to the identification of functions carried out by design in life of society in general and a sense-creating role interpretation of design language in life of the individual that leads to the realization of the analysis necessity of a design role in the sphere of modern professional education. The design as the…