Science.gov

Sample records for modification proposal evaluation

  1. Evaluation of proposed panel closure modifications at WIPP

    SciTech Connect

    Allen, Lawrence E.; Silva, Matthew K.; Channell, James K.; Abel, John F.; Morgan, Dudley R.

    2001-12-31

    A key component in the design of the WIPP repository is the installation of concrete structures as panel seals in the intake and exhaust drifts after a panel has been filled with waste containers. As noted in the EPA final rule, the panel seal closure system is intended to block brine flow between the waste panels at the WIPP. On April 17, 2001, the DOE proposed seven modifications to the EPA concerning the design of the panel closure system. EPA approval of these modifications is necessary since the details of the panel design are specified in EPA’s final rule as a condition for WIPP certification. However, the EPA has not determined whether a rulemaking would be required for these proposed design modifications. On September 4, 2001, the DOE withdrew the request, noting that it would be resubmitted on a future date. The Environmental Evaluation Group (EEG) contracted with two engineers, Dr. John Abel and Dr. Rusty Morgan, to evaluate the proposed modifications. The EEG has accepted the conclusions and recommendations from these two experts: 1) replacement of Salado Mass Concrete with a generic salt-based concrete; 2) replacement of the explosion wall with a construction wall; 3) replacement of freshwater grouting with salt-based grouting; 4) option to allow surface or underground mixing; and 5) option to allow up to one year for completion of closure. The proposed modification to allow local carbonate river rock as aggregate is acceptable pending demonstration that no problems will exist in the resulting concrete. The proposed modification to give the contractor discretion in removal of steel forms is not supported. Instead, several recommendations are made to specifically reduce the number of forms left, thereby reducing potential migration pathways.

  2. Proposed Modification to the Plutonium Systemic Model.

    PubMed

    Konzen, Kevin; Miller, Scott; Brey, Richard

    2015-10-01

    The currently accepted biokinetic model for plutonium distribution within the human body was recommended by the International Commission on Radiological Protection in publication 67. This model was developed from human and animal studies and behavioral knowledge acquired from other known bone-seeking radionuclides. The biokinetic model provides a mathematical means of predicting the distribution, retention, and clearance of plutonium within the human body that may be used in deriving organ, tissue, and whole body dose. This work proposed a modification to the ICRP 67 systemic model for plutonium that incorporated the latest knowledge acquired from recent human injection studies with physiologically based improvements. In summary, the changes included a separation of the liver compartments, removed the intermediate soft tissue-to-bladder pathway, and added pathways from the blood compartment to both the cortical and trabecular bone volumes. The proposed model provided improved predictions for several bioassay indicators compared to the ICRP 67 model while also maintaining its basic structure. Additionally, the proposed model incorporated physiologically based improvements for the liver and skeleton and continued to ensure efficient coupling with intake biokinetic models.

  3. How to use the new DSM-5 somatic symptom disorder diagnosis in research and practice: a critical evaluation and a proposal for modifications.

    PubMed

    Rief, Winfried; Martin, Alexandra

    2014-01-01

    The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) changed the term "somatoform disorders" to "somatic symptom and related disorders" and further modified diagnostic labels and criteria. We review evidence for the validity of the new criteria, specifically of somatic symptom disorder (SSD), and present a critical discussion of unsolved and new problems. We also provide an update of mechanisms and interventions that have been empirically evaluated in somatoform disorders. For many mechanisms, it is unclear whether their role can be easily transposed to SSD. Therefore more research is needed on the similarities and differences between medically unexplained and medically explained conditions. To overcome the obvious shortcomings of the current classification, we offer a modification of this DSM-5 section as well as a crossover system to apply these criteria for somatic symptom and related disorders. This proposal allows working with DSM-5 but also continuing successful lines of research with concepts such as hypochondriasis/illness anxiety, chronic pain, and medically unexplained versus medically explained syndromes.

  4. Aircraft Modification Management Evaluation

    DTIC Science & Technology

    1980-12-01

    Configuration Control Board Deputy for Avionics Control - Department of Defense - Full Scale Engineering Development - Fiscal Year - Major Air...and Analysis AFLC System Manager AFLC Configuratio Control Board Reviews HPA and subaits it to the Air Staff *0 Installation Preparation...management control system used to ensure that the deficiencies are evaluated and resolved by the appropriate function ele- ments. The ALC

  5. Electric utility engineer`s FGD manual -- Volume 2: Major mechanical equipment; FGD proposal evaluations; Use of FGDPRISM in FGD system modification, proposal, evaluation, and design; FGD system case study. Final report

    SciTech Connect

    1996-03-04

    Part 2 of this manual provides the electric utility engineer with detailed technical information on some of the major mechanical equipment used in the FGD system. The objectives of Part 2 are the following: to provide the electric utility engineer with information on equipment that may be unfamiliar to him, including ball mills, vacuum filters, and mist eliminators; and to identify the unique technique considerations imposed by an FGD system on more familiar electric utility equipment such as fans, gas dampers, piping, valves, and pumps. Part 3 provides an overview of the recommended procedures for evaluating proposals received from FGD system vendors. The objectives are to provide procedures for evaluating the technical aspects of proposals, and to provide procedures for determining the total costs of proposals considering both initial capital costs and annual operating and maintenance costs. The primary objective of Part 4 of this manual is to provide the utility engineer who has a special interest in the capabilities of FGDPRISM [Flue Gas Desulfurization PRocess Integration and Simulation Model] with more detailed discussions of its uses, requirements, and limitations. Part 5 is a case study in using this manual in the preparation of a purchase specification and in the evaluation of proposals received from vendors. The objectives are to demonstrate how the information contained in Parts 1 and 2 can be used to improve the technical content of an FGD system purchase specification; to demonstrate how the techniques presented in Part 3 can be used to evaluate proposals received in response to the purchase specification; and to illustrate how the FGDPRISM computer program can be used to establish design parameters for the specification and evaluate vendor designs.

  6. Project Proposals Evaluation

    NASA Astrophysics Data System (ADS)

    Encheva, Sylvia; Tumin, Sharil

    2009-08-01

    Collaboration among various firms has been traditionally used trough single project joint ventures for bonding purposes. Eventhough the performed work is usually beneficial to some extend to all participants, the type of collaboration option to be adapted is strongly influenced by overall purposes and goals that can be achieved. In order to facilitate a choice of collaboration option best suited to a firm's need a computer based model is proposed.

  7. 78 FR 59345 - Proposed Information Collection Request; Comment Request; Modification of Secondary Treatment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... AGENCY Proposed Information Collection Request; Comment Request; Modification of Secondary Treatment... request (ICR), ``Modification of Secondary Treatment Requirements for Discharges into Marine Waters... appropriate automated electronic, mechanical, or other technological collection techniques or other forms...

  8. Major Modification Determination Process Utilized for Proposed Idaho National Laboratory Projects

    SciTech Connect

    Michael A. Lehto, Ph.D.; Boyd D. Christensen

    2008-05-01

    Over the past three years, several new projects with the potential for major modifications to existing facilities have been considered for implementation at the Idaho National Laboratory (INL). These projects were designated to take place in existing nuclear facilities with existing documented safety analyses. 10 CFR 830.206 requires the contractor for a major modification to a Hazard Category 1, 2, or 3 nuclear facility to obtain Department of Energy (DOE) approval for the nuclear facility design criteria to be used for preparation of a preliminary documented safety analysis (PDSA), as well as creation and approval of the PDSA, before the contractor can procure materials or components or begin construction on the project. Given the significant effort and expense of preparation and approval of a PDSA, a major modification determination for new projects is warranted to determine if the rigorous requirements of a major modification are actually required. Furthermore, performing a major modification determination helps to ensure that important safety aspects of a project are appropriately considered prior to modification construction or equipment procurement. The projects considered for major modification status at the INL included: treatment and packaging of unirradiated, sodium-bonded highly enriched uranium (HEU) fuel and miscellaneous casting scrap in the Materials and Fuels Complex (MFC) Fuel Manufacturing Facility (FMF); post irradiation examination of Advance Fuel Cycle Initiative (AFCI) fuel in the MFC Analytical Laboratory (AL); the Advanced Test Reactor (ATR) gas test loop (GTL); and the hydraulic shuttle irradiation system (HSIS) at ATR. The major modification determinations for three of the proposed projects resulted in a negative major modification. On the other hand, the major modification determination for the GTL project concluded that the project would require a major modification. This paper discusses the process, methods, and considerations used by

  9. Zone III flexor tendon injuries - A proposed modification to rehabilitation.

    PubMed

    Chinchalkar, Shrikant J; Pipicelli, Joey G; Agur, Anne; Athwal, George S

    2015-01-01

    In this manuscript, these authors have utilized years of clinical experience to suggest rehabilitation modifications for Zone III flexor tendon injuries. - VictoriaPriganc, PhD, OTR, CHT, CLT, Practice Forum Editor.

  10. 75 FR 13049 - Proposed Modification of Class B Airspace; Charlotte, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ...; Charlotte, NC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking... the Federal Register of March 3, 2010, regarding the modification of Class B airspace, Charlotte,...

  11. 48 CFR 2415.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... technical portion of each proposal to the TEP Chairperson or his or her designee. The cost/price portion of... TEP. (3) Technical evaluation. The TEP shall rate each proposal based on the evaluation factors specified in the solicitation. The TEP shall identify each proposal as being either acceptable,...

  12. 78 FR 5471 - Availability of Draft Environmental Assessment for the Proposed Modification of the Bayonne...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... Bayonne Bridge Across the Kill Van Kull Between Bayonne, Hudson County, NJ and Staten Island, Richmond...-economic impacts of the proposed modification of the historic Bayonne Bridge across the Kill Van Kull... the modification to the Bayonne Bridge across the Kill Van Kull. DATES: Written comments and...

  13. [Gardnerella vaginalis biotypes: modification of a proposed system].

    PubMed

    Pedraza-Avilés, A G; Inzunza-Montiel, A E; Ortíz-Zaragoza, M C; Morales-Espinosa, M R; Ponce-Rosas, E R

    1995-01-01

    A modified scheme is proposed for biotyping Gardnerella vaginalis based on detection of hippurate hydrolysis, beta-galactosidase (ONPG) and lipase, and fermentation of arabinose, galactose and xylose. Thirty three biotypes were found among 140 strains from women with and without bacterial vaginosis (non-specific vaginitis). The distribution of biotypes were found to be significantly different, being more predominant the biotypes 1A; 5G; 7A; 7D and 7G in women with vaginosis and the biotypes 5G and 6H in women without vaginosis. These data suggest that some biotypes of Gardnerella vaginalis are associated with bacterial vaginosis.

  14. 76 FR 18723 - Proposed Information Collection; Comment Request; Weather Modification Activities Reports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Proposed Information Collection; Comment Request; Weather... requires that persons who engage in weather modification activities (e.g., cloud seeding) provide...

  15. 75 FR 5704 - Proposed Modification of Jet Routes J-37 and J-55; Northeast United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Proposed Modification of Jet Routes J-37 and J-55; Northeast United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to modify Jet Routes J-37 and J-55 in...

  16. 48 CFR 15.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... contract successfully. An agency shall evaluate competitive proposals and then assess their relative... weights, and ordinal rankings. The relative strengths, deficiencies, significant weaknesses, and risks...) Past performance evaluation. (i) Past performance information is one indicator of an offeror's...

  17. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost...

  18. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost...

  19. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost...

  20. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost...

  1. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Proposal evaluation. 915.305 Section 915.305 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation....

  2. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 915.305 Section 915.305 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation....

  3. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Proposal evaluation. 915.305 Section 915.305 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation....

  4. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Proposal evaluation. 915.305 Section 915.305 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation....

  5. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Proposal evaluation. 915.305 Section 915.305 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation....

  6. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost...

  7. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 715... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 715.305 Proposal evaluation....spu@aidw/Internet: pastperformance@usaid.gov.) (b) A justification is to be written by the...

  8. 48 CFR 2015.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 2015.305 Section 2015.305 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING... evaluation. The Source Evaluation Panel shall use this information to perform an accurate...

  9. 75 FR 27229 - Proposed Modification of Class B Airspace; Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class B Airspace; Chicago, IL...: This action proposes to modify the Chicago, IL, Class B airspace area by expanding the existing... procedures within Class B airspace, and segregating IFR aircraft at Chicago O'Hare International Airport...

  10. 76 FR 28687 - Proposed Modification of Class E Airspace; Newcastle, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class E Airspace; Newcastle, WY Correction In proposed rule document 2011-8743 appearing on pages 20281-20282 in the issue of Tuesday,...

  11. 76 FR 35371 - Proposed Modification of the Las Vegas, NV, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Las Vegas, NV, Class B... information from airspace users and others, concerning a proposal to modify Class B airspace at Las Vegas, NV... Centennial Parkway, Las Vegas, NV 89149; (2) The meeting on Tuesday, August 23, 2011, will be held...

  12. 75 FR 2582 - Proposed Modification of the Atlanta, GA, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ..., in Covington, GA, as published in the Federal Register on Friday, December 4, 2009 (74 FR 63818), FR... Federal Aviation Administration Proposed Modification of the Atlanta, GA, Class B Airspace Area; Public... Friday, December 4, 2009, concerning a proposal to revise Class B airspace at Atlanta, GA, (74 FR...

  13. 78 FR 25406 - Proposed Modification of Class E Airspace; Twin Falls, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class E Airspace; Twin Falls, ID...: This action proposes to modify Class E airspace at Twin Falls Joslin Field-Magic Valley Regional Airport, Twin Falls, ID. Controlled airspace is necessary to accommodate aircraft using the...

  14. 76 FR 76070 - Proposed Modification of Area Navigation Route T-288; WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Area Navigation Route T-288; WY...: This action proposes to modify low altitude area navigation (RNAV) route T-288 by extending the route... airway structure and providing alternative routing in the event of navigation aid (NAVAID) outages....

  15. 75 FR 5703 - Proposed Modification of Jet Route J-3; Spokane, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Jet Route J-3; Spokane, WA AGENCY... action proposes to modify Jet Route J-3 by terminating the route at the Spokane, WA, VHF omnidirectional... to Title 14 Code of Federal Regulations (14 CFR) part 71 to remove the segment of J-3 that...

  16. Evaluation of materials and design modifications for aircraft brakes

    NASA Technical Reports Server (NTRS)

    Ho, T. L.; Kennedy, F. E.; Peterson, M. B.

    1975-01-01

    A test program is described which was carried out to evaluate several proposed design modifications and several high-temperature friction materials for use in aircraft disk brakes. The evaluation program was carried out on a specially built test apparatus utilizing a disk brake and wheel half from a small het aircraft. The apparatus enabled control of brake pressure, velocity, and braking time. Tests were run under both constant and variable velocity conditions and covered a kinetic energy range similar to that encountered in aircraft brake service. The results of the design evaluation program showed that some improvement in brake performance can be realized by making design changes in the components of the brake containing friction material. The materials evaluation showed that two friction materials show potential for use in aircraft disk brakes. One of the materials is a nickel-based sintered composite, while the other is a molybdenum-based material. Both materials show much lower wear rates than conventional copper-based materials and are better able to withstand the high temperatures encountered during braking. Additional materials improvement is necessary since both materials show a significant negative slope of the friction-velocity curve at low velocities.

  17. Proposed modifications of Environmental Protection Agency Method 1601 for detection of coliphages in drinking water, with same-day fluorescence-based detection and evaluation by the performance-based measurement system and alternative test protocol validation approaches.

    PubMed

    Salter, Robert S; Durbin, Gregory W; Conklin, Ernestine; Rosen, Jeff; Clancy, Jennifer

    2010-12-01

    Coliphages are microbial indicators specified in the Ground Water Rule that can be used to monitor for potential fecal contamination of drinking water. The Total Coliform Rule specifies coliform and Escherichia coli indicators for municipal water quality testing; thus, coliphage indicator use is less common and advances in detection methodology are less frequent. Coliphages are viral structures and, compared to bacterial indicators, are more resistant to disinfection and diffuse further distances from pollution sources. Therefore, coliphage presence may serve as a better predictor of groundwater quality. This study describes Fast Phage, a 16- to 24-h presence/absence modification of U.S. Environmental Protection Agency (EPA) Method 1601 for detection of coliphages in 100 ml water. The objective of the study is to demonstrate that the somatic and male-specific coliphage modifications provide results equivalent to those of Method 1601. Five laboratories compared the modifications, featuring same-day fluorescence-based prediction, to Method 1601 by using the performance-based measurement system (PBMS) criterion. This requires a minimum 50% positive response in 10 replicates of 100-ml water samples at coliphage contamination levels of 1.3 to 1.5 PFU/100 ml. The laboratories showed that Fast Phage meets PBMS criteria with 83.5 to 92.1% correlation of the same-day rapid fluorescence-based prediction with the next-day result. Somatic coliphage PBMS data are compared to manufacturer development data that followed the EPA alternative test protocol (ATP) validation approach. Statistical analysis of the data sets indicates that PBMS utilizes fewer samples than does the ATP approach but with similar conclusions. Results support testing the coliphage modifications by using an EPA-approved national PBMS approach with collaboratively shared samples.

  18. Modification and evaluation of fuel cell membranes

    NASA Astrophysics Data System (ADS)

    Nalawade, Amol Prataprao

    The primary goals of this study were modification of existing NafionRTM membranes and characterization of newly developed hydrocarbon-based membranes for high temperature fuel cell applications. Various NafionRTM/silicate nanocomposites were formulated via in situ sol-gel reactions for tetraethylorthosilicate. Different silicate composition profiles generated across membrane cross-sections were investigated by EDAX/ESEM. Composite water uptake, proton conductivity and fuel cell performance were comparable to that of unmodified Nafion RTM. Tafel analysis showed better electrode kinetics for composites having more silicate in the middle and less or no silicate at electrolyte-electrode interfaces. All composites showed reduced fuel cross-over and superior mechanical as well as chemical durability than unmodified NafionRTM. Poly(cyclohexadiene) (PCHD) materials were characterized in the interest of developing alternative low-cost proton exchange membranes. All cross-linked sulfonated (xsPCHD) membranes showed significantly higher water uptake at 80 °C and higher proton conductivity at 120 °C at all relative humidities (RH), compared to the current benchmark membrane, NafionRTM. A xsPCHD-poly(ethylene glycol) (PEG) copolymer and a xsPCHD-PEG blend surpassed the DOE target by exhibiting proton conductivities of 141.44 and 322.40 mS/cm, respectively, at 50 % RH. Although the PCHD-based PEMs exhibited thermal stability up to 150 °C, they showed poor mechanical properties which would cause poor membrane durability during fuel cell operation. Atomic force microscopy studies demonstrated nanophase separated morphology of xsPCHD having a higher degree of connectedness of hydrophilic domains in the copolymer and blends relative to the xsPCHD homopolymer. Broadband dielectric spectroscopy (BDS) was used to study sub-Tg relaxations in annealed poly(2,5-benzimidazole) (ABPBI) fuel cell precursor materials. A trend in degree of connectivity of charge migration pathways and

  19. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... (x) Incorporate flexibility to adapt more easily to changes in the health care infrastructure (such... proposed modifications. 162.940 Section 162.940 Public Welfare Department of Health and Human Services... effectiveness of the health care system by leading to cost reductions for, or improvements in benefits...

  20. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... (x) Incorporate flexibility to adapt more easily to changes in the health care infrastructure (such... proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... effectiveness of the health care system by leading to cost reductions for, or improvements in benefits...

  1. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... (x) Incorporate flexibility to adapt more easily to changes in the health care infrastructure (such... proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... effectiveness of the health care system by leading to cost reductions for, or improvements in benefits...

  2. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... (x) Incorporate flexibility to adapt more easily to changes in the health care infrastructure (such... proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... effectiveness of the health care system by leading to cost reductions for, or improvements in benefits...

  3. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Submission, modification, revision, and withdrawal of proposals. 315.208 Section 315.208 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION...

  4. 40 CFR 194.65 - Notice of proposed rulemaking for modification or revocation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Notice of proposed rulemaking for modification or revocation. 194.65 Section 194.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS CRITERIA FOR THE CERTIFICATION AND RE-CERTIFICATION OF THE...

  5. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Submission, modification, revision, and withdrawal of proposals. 315.208 Section 315.208 Federal Acquisition Regulations System... Acquisition, if an HCA determines that certain classes of biomedical or behavioral R & D acquisitions...

  6. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Submission, modification, revision, and withdrawal of proposals. 315.208 Section 315.208 Federal Acquisition Regulations System... Acquisition, if an HCA determines that certain classes of biomedical or behavioral R & D acquisitions...

  7. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Submission, modification, revision, and withdrawal of proposals. 315.208 Section 315.208 Federal Acquisition Regulations System... Acquisition, if an HCA determines that certain classes of biomedical or behavioral R & D acquisitions...

  8. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Submission, modification, revision, and withdrawal of proposals. 315.208 Section 315.208 Federal Acquisition Regulations System... Acquisition, if an HCA determines that certain classes of biomedical or behavioral R & D acquisitions...

  9. 75 FR 26891 - Proposed Modification of the Detroit, MI, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Detroit, MI, Class B Airspace Area; Public Meetings AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of public..., Federal Aviation Administration, 2601 Meacham Boulevard, Fort Worth, Texas 76137, or by fax to (817)...

  10. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... as new services, organizations, and provider types) and information technology. (2) Specifications... exception. The Secretary may grant an initial exception, for a period not to exceed 3 years, based on,...

  11. The Evaluation of Litter Behavior Modification in a River Environment.

    ERIC Educational Resources Information Center

    Wagstaff, Mark C.; Wilson, Beth E.

    1988-01-01

    Behavior modification techniques were evaluated by observing litter collection behavior of commercial rafting groups. The number of litter pieces retrieved by treatment and control groups was significantly different. Results support the idea that verbal appeal and role modeling can be effective litter control techniques. (Author/CW)

  12. Silica aerogel threshold Cherenkov counters for the JLab Hall A spectrometers: improvements and proposed modifications

    SciTech Connect

    Luigi Lagamba; Evaristo Cisbani; S. Colilli; R. Crateri; R. De Leo; Salvatore Frullani; Franco Garibaldi; F. Giuliani; M. Gricia; Mauro Iodice; Riccardo Iommi; A. Leone; M. Lucentini; A. Mostarda; E. Nappi; Roberto Perrino; L. Pierangeli; F. Santavenere; Guido M. Urciuoli

    2001-10-01

    Recently approved experiments at Jefferson Lab Hall A require a clean kaon identification in a large electron, pion, and proton background environment. To this end, improved performance is required of the silica aerogel threshold Cherenkov counters installed in the focal plane of the two Hall A spectrometers. In this paper we propose two strategies to improve the performance of the Cherenkov counters which presently use a hydrophilic aerogel radiator, and convey Cherenkov photons towards the photomultipliers by means of mirrors with a parabolic shape in one direction and flat in the other. The first strategy is aerogel baking. In the second strategy we propose a modification of the counter geometry by replacing the mirrors with a planar diffusing surface and by displacing in a different way the photomultipliers. Tests at CERN with a 5GeV/c multiparticle beam revealed that both the strategies are able to increase significantly the number of the detected Cherenkov photons and, therefore, the detector performance.

  13. 77 FR 64126 - Notice of Proposed Withdrawal of Public Land for the Buffalo Bill Dam and Reservoir Modification...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... Bureau of Land Management Notice of Proposed Withdrawal of Public Land for the Buffalo Bill Dam and... recreational facilities constructed in connection with the Buffalo Bill Dam and Reservoir Modification Project... recreation site in the Buffalo Bill Dam and Reservoir Modification Project area: Sixth Principal Meridian...

  14. Proposed modifications to the Lower Mokelumne River Project, California: FERC Project No. 2916-004. Final environmental impact statement

    SciTech Connect

    Not Available

    1993-11-01

    This final environmental impact statement (FEIS) has been prepared for the Federal Energy Regulatory Commission (Commission) to consider modifications to the existing Lower Mokelumne River Project (LMRP) (FERC Project No. 2916-004) in California. Chinook salmon and steelhead trout populations in the lower Mokelumne River have experienced recent declines and fish kills associated, in part, with discharges from Camanche Dam. The California Department of Fish and Game and the California Sportfishing Protection Alliance have asked the Commission to investigate and correct these problems. A wide range of different mitigation actions has been proposed by parties participating in the scoping of this proceeding, and staff has evaluated these proposed actions in this assessment. The staff is recommending a combination of flow and non-flow modifications to the existing license, including new minimum flow and minimum pool elevation requirements at Camanche Reservoir, ramping rates on dam releases, interim attraction and out-migrant spike flows, instream habitat improvements, and a series of studies and monitoring to determine feasible means for solving off-site fish passage problems.

  15. Environmental Assessment for the proposed modification and continued operation of the DIII-D facility

    SciTech Connect

    1995-07-01

    The EA evaluates the proposed action of modifying the DIII-D fusion facility and conducting related research activities at the GA San Diego site over 1995-1999 under DOE contract number DE-ACO3-89ER51114. The proposed action is need to advance magnetic fusion research for future generation fusion devices such as ITER and TPX. It was determined that the proposed action is not a major action significantly affecting the quality of the human environment according to NEPA; therefore a finding of no significant impact is made and an environmental impact statement is not required.

  16. A Proposed RTN Officer Performance Evaluation System

    DTIC Science & Technology

    1989-12-01

    studiod at the Naval Postpraduate School and practical theories relating to personnel management and performance evaluation. 4 The research method includes...various systems are discussed as the researcher perceives them. The fact that there is probably no agreed upon, fool-proof method of evaluating an...Performance Evaluation System. The research methodology Includes the following three componen: (1) a study of pertinent performance evaluation

  17. 75 FR 73983 - Proposed Modification of the Salt Lake City, UT, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Salt Lake City, UT, Class B... information from airspace users and others concerning a proposal to revise the Class B airspace area at Salt... Terminal, 397 North 2370 West, Salt Lake City, UT 84116. (3) The meeting on Thursday, February 3,...

  18. 76 FR 37034 - Proposed Modification of the Las Vegas, NV, Class B Airspace Area; Public Meetings; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Las Vegas, NV, Class B... of June 17, 2011, concerning a proposal to modify Class B airspace at Las Vegas, NV. The document... Gough, Manager, Airspace and Procedures, and Bill Ruggiero, Support Manager Las Vegas, TRACON,...

  19. A Proposal: Modification for Instruments and Tools Used in the Science Laboratory Setting for Students with Disabilities

    ERIC Educational Resources Information Center

    Kogan, Denis

    2015-01-01

    The purpose of this action research proposal is to create a Modification of Instruments and Tools in Science (MITS) program to address the need for providing Students With Disabilities (SWDs) appropriate access to scientific tools and techniques of scientific inquiry. This proposal contains a review of literature on SWDs, differentiating…

  20. 48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the Government for evaluation or advice shall be approved in writing by the HCA; (2) Outside... proposal evaluation. 1415.207-71 Section 1415.207-71 Federal Acquisition Regulations System DEPARTMENT OF... Receipt of Proposals and Information 1415.207-71 Confidentiality of proposal evaluation. (a)...

  1. 48 CFR 315.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... adequately reflect the written technical report comments. (D) Conflict of interest. (1) If a panel member has... requirement for a technical evaluation report in accordance with paragraph (a)(3)(vi) of this section. (5) The establishment of a date for receipt of the technical evaluation report. (iv) Convening the technical...

  2. Evaluation of milk powder quality by protein oxidative modifications.

    PubMed

    Scheidegger, Dana; Radici, Paola M; Vergara-Roig, Víctor A; Bosio, Noelia S; Pesce, Silvia F; Pecora, Rolando P; Romano, José C P; Kivatinitz, Silvia C

    2013-06-01

    The objective of the present research was to evaluate commercially available milk powders according to their protein oxidative modifications and antioxidant capacity, and to evaluate if these characteristics are related to physical quality parameters such as dispersibility or stability during storage. Fifteen commercially processed spray-dried milk powders were evaluated: 6 whole milk powders (WMP), 4 skim milk powders (SMP), and 5 infant formula powders (IFP). Protein oxidative status was measured as protein carbonyl (PC) content, dityrosine content, and extent of protein polymerization. The level of PC was slightly lower in SMP than in WMP, whereas IFP had more than twice as much PC as WMP (2.8 ± 0.4, 2.1 ± 0.2, and 6.5 ± 1.3 nmol/mg of protein for WMP, SMP, and IFP, respectively). No differences were detected in dityrosine accumulation. Although all the possible pairs of parameters were tested for correlations, we found that 4 parameters were linked: PC, whey content, protein aggregate level, and dispersibility. After 9 mo of storage at -20°C or room temperature, all milk samples were analyzed to evaluate changes in protein oxidative status (PC, dityrosine, and protein integrity) and related parameters. Compared with the initial condition, PC increased in all tested samples after 9 mo of storage at -20°C or at room temperature. Stored milk powders had increased PC and decreased dispersibility compared with prestorage levels. Our results highlight the importance of protein oxidative status in milk powder and its relationship to other related quality parameters, such as protein integrity and dispersibility. Our findings suggest that the understanding of such relationships could help in developing quality differentiation for different types of milk powders in the product market.

  3. 78 FR 47010 - Proposed Safety Evaluation for Plant-Specific

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... COMMISSION Proposed Safety Evaluation for Plant-Specific Technical Specifications Task Force Traveler... requesting public comment on the proposed model safety evaluation (SE) for plant- specific adoption of... ADAMS Accession Number ML13053A075. The proposed model SE for plant-specific adoption of...

  4. 7 CFR 3406.20 - Evaluation criteria for research proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Evaluation criteria for research proposals. 3406.20... RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Review and Evaluation of a Research Proposal § 3406.20 Evaluation criteria for...

  5. Effects of proposed highway embankment modifications on water-surface elevations in the lower Pearl River flood plain near Slidell, Louisiana

    USGS Publications Warehouse

    Gilbert, J.J.; Schuck-Kolben, R. E.

    1987-01-01

    Major flooding in the lower Pearl River basin in recent years has caused extensive damage to homes and highways in the area. In 1980 and 1983, Interstate Highway 10 and U.S. Highway 190 were overtopped. In 1983, the Interstate Highway 10 crossing was seriously damaged by the flood. The U.S. Geological Survey, in cooperation with the Louisiana Department of Transportation and Development, Office of Highways, used a two-dimensional finite-element surface-water flow model to evaluate the effects the proposed embankment modifications at Interstate Highway 10 and U.S. Highway 90 on the water-surface elevations in the lower Pearl River flood plain near Slidell, Louisiana. The proposed modifications that were considered for the 1983 flood are: (1) Removal of all highway embankments, the natural condition, (2) extension of the West Pearl River bridge by 1,000 feet at U.S. Highway 90, (3) construction of a new 250-foot bridge opening in the U.S. Highways 190 and 90, west of the intersection of the highways. The proposed highway bridge modifications also incorporated lowering of ground-surface elevations under the new bridges to sea level. The modification that provided the largest reduction in backwater, about 35 percent, was a new bridge in Interstate Highway 10. The modification of the West Pearl River bridge at U.S. Highway 90 and replacement of the bridge in U.S. Highway 190 provide about a 25% reduction in backwater each. For the other modification conditions that required structural modifications, maximum backwater computed on the west side of the flood plain ranges from 0.0 to 0.8 foot and on the east side from 0.0 to 0.6 foot. Results show that although backwater is greater on the west side of the flood plain than on the east side, upstream of highway embankments, backwater decreases more rapidly in the upstream direction on the west side of the flood plain than on the east side. Analysis of the proposed modifications indicates that backwater would still occur on

  6. 76 FR 28242 - Notice of Lodging of Proposed Modification to Consent Decree Under the Resource Conservation and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-16

    ... of Lodging of Proposed Modification to Consent Decree Under the Resource Conservation and Recovery..., Environment and Natural Resources Division, and either e-mailed to pubcomment-ees.enrd@usdoj.gov or mailed to... Section Chief, Environmental Enforcement Section, Environment and Natural Resources Division. BILLING...

  7. 78 FR 5761 - Proposed Modification of Significant New Uses of Ethaneperoxoic Acid, 1,1-Dimethylpropyl Ester

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... AGENCY 40 CFR Part 721 RIN 2070-AB27 Proposed Modification of Significant New Uses of Ethaneperoxoic Acid... rule (SNUR) for the chemical substance identified as ethaneperoxoic acid, 1,1-dimethylpropyl ester..., process, or use the chemical substance identified as ethaneperoxoic acid, 1,1-dimethylpropyl ester (PMN...

  8. 77 FR 53907 - Notice of Proposed Withdrawal Modification and Transfer of Administrative Jurisdiction; Montana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ...-0940. FOR FURTHER INFORMATION CONTACT: Pam Wall, BLM, Miles City Field Office, 111 Garryowen Road.... Water will not be needed to fulfill the purpose of the withdrawal modification and transfer...

  9. 78 FR 78303 - Proposed Modification of Area Navigation (RNAV) Route T-265, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ... be submitted in triplicate to the Docket Management Facility (see ADDRESSES section for address and... frequency changes between the two facilities. This modification would shorten T- 265 by almost two...

  10. Evaluation criteria for commercially oriented materials processing in space proposals

    NASA Technical Reports Server (NTRS)

    Moore, W. F.; Mcdowell, J. R.

    1979-01-01

    An approach and criteria for evaluating NASA funded experiments and demonstrations which have commercial potential were developed. Methods for insuring quick initial screening of commercial proposals are presented. Recommendations are given for modifying the current evaluation approach. New criteria for evaluating commercially orientated materials processing in space (MPS) proposals are introduced. The process for selection of qualified individuals to evaluate the phases of this approach and criteria is considered and guidelines are set for its implementation.

  11. A Review of The Society for Assisted Reproductive Technology Embryo Grading System and Proposed Modification

    PubMed Central

    Hossain, Amjad; Phelps, John; Agarwal, Ashok; Sanz, Eduardo; Mahadevan, Maha

    2016-01-01

    The Society for Assisted Reproductive Technology (SART) method of embryo grad- ing is unique, simple, and widely practiced, and its use has been mandatory for SART membership programs since 2010. Developed by SART in 2006, the current embryo grading system categories, “good, fair, and poor,” are limited because they do not describe the best 1-2 embryos in the interest of keeping pace with the shift in clinical practice to be more selective and to transfer fewer embryos. This inspired us to conduct a review on the SART embryo grading system. In this retrospective study, the literature on evaluation of human embryo quality in gen- eral, and the SART method of evaluation in particular, were reviewed for the period of 2000 to 2014. A multifaceted search pertaining to methods of embryo grading and trans- fer using a combination of relevant terms [embryo, mammalian, embryo transfer, grade, grading, morphology, biomarkers, SART, and in vitro fertilization (IVF)] was performed. The inclusion and exclusion in this review were dictated by the aim and scope of the study. Two investigators independently assessed the studies and extracted information. A total of 61 articles were reviewed. Very few studies have evaluated the efficacy of the SART embryo grading method. The present study suggests the necessity for revision of the current SART grading system. The system, as it is now, lacks criteria for describing the cohort specific best embryo and thus is of limited use in single embryo transfer. The study foresees heightened descriptive efficiency of the SART system by implementing the proposed changes. Strengths and weaknesses of the SART embryo grading were identified. Ideas for selecting the best cohort-specific embryo have been discussed, which may trigger methodological improvement in SART and other embryo grading systems. PMID:27441045

  12. A Review of The Society for Assisted Reproductive Technology Embryo Grading System and Proposed Modification.

    PubMed

    Hossain, Amjad; Phelps, John; Agarwal, Ashok; Sanz, Eduardo; Mahadevan, Maha

    2016-01-01

    The Society for Assisted Reproductive Technology (SART) method of embryo grad- ing is unique, simple, and widely practiced, and its use has been mandatory for SART membership programs since 2010. Developed by SART in 2006, the current embryo grading system categories, "good, fair, and poor," are limited because they do not describe the best 1-2 embryos in the interest of keeping pace with the shift in clinical practice to be more selective and to transfer fewer embryos. This inspired us to conduct a review on the SART embryo grading system. In this retrospective study, the literature on evaluation of human embryo quality in gen- eral, and the SART method of evaluation in particular, were reviewed for the period of 2000 to 2014. A multifaceted search pertaining to methods of embryo grading and trans- fer using a combination of relevant terms [embryo, mammalian, embryo transfer, grade, grading, morphology, biomarkers, SART, and in vitro fertilization (IVF)] was performed. The inclusion and exclusion in this review were dictated by the aim and scope of the study. Two investigators independently assessed the studies and extracted information. A total of 61 articles were reviewed. Very few studies have evaluated the efficacy of the SART embryo grading method. The present study suggests the necessity for revision of the current SART grading system. The system, as it is now, lacks criteria for describing the cohort specific best embryo and thus is of limited use in single embryo transfer. The study foresees heightened descriptive efficiency of the SART system by implementing the proposed changes. Strengths and weaknesses of the SART embryo grading were identified. Ideas for selecting the best cohort-specific embryo have been discussed, which may trigger methodological improvement in SART and other embryo grading systems.

  13. 78 FR 10560 - Proposed Modification and Revocation of Air Traffic Service Routes; Jackson, MS

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... Modification and Revocation of Air Traffic Service Routes; Jackson, MS AGENCY: Federal Aviation Administration... jet routes and seven VOR Federal airways; and remove two VOR Federal airways in the vicinity of... amendment to Title 14, Code of Federal Regulations (14 CFR) part 71 to modify two jet routes and seven...

  14. 78 FR 740 - Availability of Draft Environmental Assessment for the Proposed Modification of the Bayonne...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ... Bayonne Bridge Across the Kill Van Kull Between Bayonne, Hudson County, NJ and Staten Island, Richmond... historic Bayonne Bridge across the Kill Van Kull between Bayonne, New Jersey and Staten Island, New York... (PANYNJ) for Coast Guard approval of the modification to the Bayonne Bridge across the Kill Van...

  15. 78 FR 33772 - Proposed Modification of Class E Airspace; Brigham City, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... Airspace; Brigham City, UT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to modify Class E airspace at Brigham City Airport, Brigham City, UT. The proposed decommissioning of the Brigham City Nondirectional Radio Beacon (NDB) has...

  16. 78 FR 76784 - Proposed Modification, Revocation, and Establishment of Area Navigation (RNAV) Routes; Charlotte, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...This action proposes to establish two RNAV routes; modify three RNAV routes; and remove one RNAV route in the Charlotte, NC, area. The route changes are proposed to support the Charlotte Optimization of Airspace and Procedures in a Metroplex (OAPM) project. The proposed routes, in combination with existing VOR Federal airways, would provide additional routing options through and around the......

  17. 78 FR 70900 - Proposed Modification of Area Navigation (RNAV) Route Q-20, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... (RNAV) Route Q-20, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to modify RNAV route Q-20 in support of the Houston Optimization of Airspace and Procedures in a Metroplex (OAPM) project. This proposed action re-aligns Q-20...

  18. Evaluation of Proposed Cab Glass Coating for FAA Control Towers

    DTIC Science & Technology

    2013-12-01

    wear vision correction? None Contacts Glasses Both If required, which correction do you use: Monofocal Bifocal Trifocal Color perception results...i AFRL-RH-WP-TR-2013-0123 Evaluation of Proposed Cab Glass Coating for FAA Control Towers Eric E. Geiselman Alan R. Pinkus, Ph.D...COVERED (From - To) 30-12-2013 Final Jun 2012 – Jun 2013 4. TITLE AND SUBTITLE Evaluation of Proposed Cab Glass Coating for FAA Control

  19. 48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Confidentiality of proposal evaluation. 1415.207-71 Section 1415.207-71 Federal Acquisition Regulations System DEPARTMENT OF... or content of proposals received to any other party (including supervisors) without the...

  20. Evaluation of optimum profile modification curves of profile shifted spur gears based on vibration responses

    NASA Astrophysics Data System (ADS)

    Ma, Hui; Pang, Xu; Feng, Ranjiao; Wen, Bangchun

    2016-03-01

    In this paper, a mesh stiffness model is developed for profile shifted gears with addendum modifications and tooth profile modifications (TPMs). The time-varying mesh stiffness (TVMS), load sharing factor (LSF), loaded static transmission error (LSTE) and non-loaded static transmission error (NLSTE) of a profile shifted spur gear pair with TPMs are obtained by the analytical model. The optimum profile modification curve under different amounts of TPM is determined by analyzing the LSTE first. Then, considering the effect of NLSTE, finite element (FE) model of a geared rotor system is established. The system vibration responses under different TPM curves are analyzed and the optimum modification curve is further evaluated by amplitude frequency responses. The results show that the optimum modification curve is related to the amount of TPM and modification coefficients. The comparison of the optimum profile modification curves is evaluated by LSTE and vibration responses, which shows that the optimum modification curve should be determined by evaluating the vibration response of the geared rotor system in the low mesh frequency range.

  1. 77 FR 27149 - Proposed Modification of Class E Airspace; Unalakleet, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... aircraft using a new Area Navigation (RNAV) Global Positioning System (GPS) standard instrument approach... be submitted in triplicate to the Docket Management System (see ADDRESSES section for address and... Proposed Rulemaking Distribution System, which describes the application procedure. The Proposal The FAA...

  2. 78 FR 70895 - Proposed Establishment and Modification of Area Navigation (RNAV) Routes; Atlanta, GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... Area Navigation (RNAV) Routes; Atlanta, GA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to establish 14 RNAV Q-routes and modify 4 Q-routes in support of the Optimization of Airspace and Procedures in a Metroplex (OAPM)...

  3. 48 CFR 1815.208 - Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... late proposal criteria do not apply to Announcements of Opportunity, NASA Research Announcements, and Small Business Innovative Research (SBIR) Phase I and Phase II solicitations, and Small Business... Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND...

  4. Proposed modifications to AOAC 996.06, optimizing the determination of trans fatty acids: presentation of data.

    PubMed

    Rozema, Brent; Mitchell, Barbara; Winters, Doug; Kohn, Andrew; Sullivan, Darryl; Meinholz, Erin

    2008-01-01

    The increased focus on the accuracy of trans fatty acid data generated using current methodologies has resulted in research initiatives to optimize the quality of these assays. In this study, scientists combined the established methodology from AOAC 996.06 and the American Oil Chemists Society method Ce 1h-05, as well as other independent research. As a result, method modifications are proposed that could allow for a more accurate determination of trans fat than the current AOAC 996.06 method. Validation data from this study are presented. The authors encourage peer review and offer to facilitate a collaborative validation to update AOAC 996.06.

  5. 78 FR 76781 - Proposed Modification of Class B Airspace; Salt Lake City, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...; Salt Lake City, UT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... Lake City Class B airspace area by raising the floor of a small portion of Class B airspace between the Salt Lake City Class B surface area and the Hill Air Force Base (AFB) Class D airspace area....

  6. 78 FR 18269 - Proposed Modification of Class E Airspace; Clifton/Morenci, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... to accommodate aircraft using Area Navigation (RNAV) Global Positioning System (GPS) standard... Airspace Docket No. 12-AWP-9) and be submitted in triplicate to the Docket Management System (see ADDRESSES.... 11-2A, Notice of Proposed Rulemaking Distribution System, which describes the application...

  7. 78 FR 76779 - Proposed Modification of the Philadelphia, PA, Class B Airspace Area

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...This action proposes to amend the description of Area G of the Philadelphia Class B airspace area to correct a design error that resulted in the Class B airspace being published 2.1 nautical miles (NM) larger on the southeast side of the area than intended. No other changes to the Philadelphia Class B airspace are being...

  8. 78 FR 65241 - Proposed Modification of Class D and Class E Airspace; Kailua-Kona, HI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ... Airspace; Kailua- Kona, HI AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... Airport at Keahole, Kailua-Kona, HI. Controlled airspace is necessary to accommodate the Area Navigation... upward from 700 feet above the surface, at Kona International Airport at Keahole, Kailua-Kona, HI....

  9. 77 FR 5733 - Proposed Modification of Area Navigation (RNAV) Route Q-62; Northeast United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-06

    ... Terminal Arrival Routes (STARs) serving the Chicago O'Hare International Airport, IL, terminal area with... terminal area airspace phase of flight. DATES: Comments must be received on or before March 22, 2012... area into the Chicago O'Hare International Airport, IL, terminal area. This proposed route...

  10. 77 FR 5429 - Proposed Modification of the Atlanta Class B Airspace Area; GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... flight through Class B airspace without an ATC clearance or radio communications requirements, the idea... aspects of the proposal. Communications should identify both docket numbers (FAA Docket No. FAA-2011-1237... postcard will be date/time stamped and returned to the commenter. All communications received on or...

  11. 78 FR 60238 - Proposed Modification and Establishment of Restricted Areas; Aberdeen Proving Ground, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ..., economic, environmental, and energy-related aspects of the proposal. Communications should identify both... winds exceed 60 knots. Lighting of the mooring cables is not practical due to technical design issues... aircraft and the efficient use of airspace. This regulation is within the scope of that authority as...

  12. 75 FR 41774 - Proposed Establishment and Modification of Class E Airspace; Deer Park, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ...; Deer Park, WA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking... airspace at Deer Park Airport, Deer Park, WA, to accommodate aircraft using the existing Area Navigation (RNAV) Global Positioning System (GPS) Standard Instrument Approach Procedures (SIAPs) at Deer...

  13. 75 FR 10818 - Proposed Modifications to the Harmonized Tariff Schedule of the United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... Harmonized Commodity Description and Coding System (Harmonized System), and the Protocol thereto, are recommended by ] the World Customs Organization (WCO) (formerly known as the Customs Cooperation Council) for... Harmonized System. The report will also include appropriate explanatory information on the proposed...

  14. 77 FR 24159 - Proposed Modification of Class E Airspace; Plentywood, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    ...: This action proposes to modify Class E airspace at Plentywood Sher-Wood Airport, Plentywood, MT... System (GPS) standard instrument approach procedures at Plentywood Sher-Wood Airport. The FAA is... Plentywood Sher-Wood Airport, Plentywood, MT. Controlled airspace is necessary to accommodate aircraft...

  15. Dopamine Surface Modification of Trititanate Nanotubes: Proposed In-Situ Structure Models.

    PubMed

    Liu, Ruochen; Fu, Xuejian; Wang, Congyi; Dawson, Graham

    2016-04-18

    Two models for self-assembled dopamine on the surface of trititanate nanotubes are proposed: individual monomer units linked by π-π stacking of the aromatic regions and mono-attached units interacting through hydrogen bonds. This was investigated with solid state NMR spectroscopy studies and powder X-ray diffraction.

  16. 76 FR 46678 - Tris carbamoyl triazine; Proposed Modification of Significant New Uses

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... that exceed 40 parts per billion (ppb) in surface waters. The proposed SNUR for this chemical substance...SAR) analysis of test data on structurally analogous substances resulted in a predicted toxicity to... substance in surface waters. Based on the results of the submitted fish and daphnid tests, fish...

  17. Evaluation and modification of CFB units at Slough Trading Estate

    SciTech Connect

    Vincent, R.Q.; Ballantyne, J.G.

    1997-12-31

    Slough Heat and Power (SHP), located just west of London, operates two circulating fluidized bed (CFB) combustion boilers (identified as FB1 and FB2) which assist in providing both power and steam to some 450 tenants located on the Slough Trading Estate. CFB technology was selected principally for (1) its fuel flexibility, (2) its ability to comply with government requirements on emissions and (3) its ability to fit the desired capacity units (with their relatively small footprint) into the limited space at the existing plant site. Construction of these units, each sized at 207,000 lb/hr at 1,260 psia and 948 F, began in 1989 with operation beginning in the latter part of 1991. Contract boiler acceptance tests were successfully passed in 1992. The units were originally intended to be operated on coal with gas and oil as back up fuels, depending on the economics. Government initiatives, designed to stimulate the development of non-fossil fueled power generation in the UK, catalyzed the owner`s interest in alternate fuels after the plant was built. Subsequently, the units have been co-fired with a blend of coal and densified refuse derived fuel (RDF) at up to a 50/50 heat input ratio. Early operation of these units was plagued by mechanical problems which affected the reliability and performance of the units. An independent assessment was made of the CFB units by FBT engineering Services to identify causes of operating, performance, and design shortcomings and to identify modifications that could be made to improve these areas. These problems have been associated with such areas of refractory, erosion, tubes and supports, clinkering and fouling, air distribution, and generally unstable unit performance. Because of the problems, the units have been operating only intermittently since commissioning. Based on the assessment of these problems, recommendations were made and design/operating changes implemented to correct these concerns and improve unit performance

  18. Protein Modification: A Proposed Mechanism for the Long-Term Pathogenesis of Traumatic Brain Injury

    DTIC Science & Technology

    2015-06-04

    cases, astrocytic foot processes appeared to surround these enlarged cells. The vast majority (>90%) of astrocytes in the injury lesion expressing...understood. It is known that a subset of ependymal cells of both the median eminence and the dorsal third ventricle extend foot -like processes into...regulated protein is an autoantigen within the pancreatic beta-cells in Type 1 diabetes (122). Collectively, these findings support the proposal that

  19. The RFP Challenge: Evaluation of Responses to Requests for Proposals.

    ERIC Educational Resources Information Center

    LeDuc, A. L.

    1993-01-01

    When a college contracts for a product or service, the request for proposal (RFP) may be an appropriate tool. It must clearly define what is needed for fair evaluation. A rating or weighting system for costs and benefits is useful for isolating and quantifying important elements of the decision-making process. (MSE)

  20. Assessment of facial form modifications in orthodontics: proposal of a modified computerized mesh diagram analysis.

    PubMed

    Ferrario, V F; Sforza, C; Dalloca, L L; DeFranco, D J

    1996-03-01

    A modified computerized mesh diagram analysis enables rapid, easy, and independent quantifications of facial size, shape, and head position. A lateral cephalometric radiograph is traced, positioned in natural head position (NHP) according to the NHP registered on a lateral photograph, and superimposed by the standard grid of rectangles determined by the patient's upper face height and face depth. The patient's tracing is compared with a reference tracing of a norm. The two tracings are registered at nasion in NHP, and the size difference of the patient's mesh rectangles from the norm is quantified by a size normalization. The shape discrepancies are evaluated by calculating relevant displacement vectors for each cephalometric landmark, and a global difference factor. This computerized method provides a rapid graphic evaluation of the patient's sagittal and vertical discrepancies and can also be applied to determine the effects of orthodontic therapy and/or growth on the skeletal and dental relationships in a single patient.

  1. [Proposal for the modification of metformin use in patients with chronic kidney disease].

    PubMed

    Balogh, Zoltán; Mátyus, János

    2012-09-30

    Metformin is the first-line, widely used oral antidiabetic agent for the management of type 2 diabetes. There is increasing evidence that metformin use results in a reduction in cardiovascular morbidity and mortality, and might have anticancer activity. An extremely rare, but potentially life-threatening adverse effect of metformin is lactic acidosis, therefore, its use is traditionally contraindicated if the glomerular filtrate rate is below 60 mL/min. However, lactic acidosis is always associated with acute events, such as hypovolemia, acute cardiorespiratory illness, severe sepsis and acute renal or hepatic failure. Furthermore, administration of insulins and conventional antihyperglycemic agents increases the risk of severe hypoglycemic events when renal function is reduced. Therefore, the magnitude of the benefit of metformin use would outweigh potential risk of lactic acidosis in moderate chronic renal disease. After reviewing the literature, the authors give a proposal for the administration of metformin, according to the calculated glomerular filtrate rate.

  2. H Scan/AHP advanced technology proposal evaluation process

    SciTech Connect

    Mack, S.; Valladares, M.R.S. de

    1996-10-01

    It is anticipated that a family of high value/impact projects will be funded by the Hydrogen Program to field test hydrogen technologies that are at advanced stages of development. These projects will add substantial value to the Program in several ways, by: demonstrating successful integration of multiple advanced technologies, providing critical insight on issues of larger scale equipment design, construction and operations management, yielding cost and performance data for competitive analysis, refining and deploying enhanced safety measures. These projects will be selected through a competitive proposal evaluation process. Because of the significant scope and funding levels of projects at these development phases, Program management has indicated the need for an augmented proposal evaluation strategy to ensure that supported projects are implemented by capable investigative teams and that their successful completion will optimally advance programmatic objectives. These objectives comprise a complex set of both quantitative and qualitative factors, many of which can only be estimated using expert judgment and opinion. To meet the above need, the National Renewable Energy Laboratory (NREL) and Energetics Inc. have jointly developed a proposal evaluation methodology called H Scan/AHP. The H Scan component of the process was developed by NREL. It is a two-part survey instrument that substantially augments the type and scope of information collected in a traditional proposal package. The AHP (Analytic Hierarchy Process) component was developed by Energetics. The AHP is an established decision support methodology that allows the Program decision makers to evaluate proposals relatively based on a unique set of weighted criteria that they have determined.

  3. UH-60 Black Hawk engineering simulation model validation and proposed modifications

    NASA Technical Reports Server (NTRS)

    Kaplita, Thaddeus T.

    1986-01-01

    The engineering simulation model of the UH-60A Black Hawk was validated using comparisons of model time histories with flight test data and updated to improve the fidelity of the model. The flight test data, acquired by the Army Aviation Engineering Flight Activity and consisting of 90 time histories of transient responses to step and pulse control inputs and 16 sets of steady flight data, were processed and compared to corresponding model time histories and trim data by Sikorsky. The current UH-60A model was judged to provide an acceptably accurate simulation for use as an analytical tool, certain unsatisfactory areas were identified and potential approaches to produce a more representative simulation were evaluated.

  4. Proposed modification to the inhalable aerosol convention applicable to realistic workplace wind speeds.

    PubMed

    Sleeth, Darrah K; Vincent, James H

    2011-06-01

    The current convention for sampling inhalable aerosols was based on several mannequin studies performed in wind tunnels at wind speeds between 0.5 and 4 m s(-1). In reality, as we now know, the wind speed in most modern indoor working environments is generally at or below ∼0.2 m s(-1). Inhalability studies performed in calm air aerosol chambers have shown that human aspiration efficiency at essentially zero wind speed is not consistent with the existing inhalable aerosol convention, calling into question the universal applicability of the current standard. More recently, experiments were carried out in a new hybrid wind tunnel-calm air chamber at more representative workplace wind speeds, between ∼0.1 and 0.5 m s(-1), to fill in this knowledge gap. Comparing these new data to both the existing inhalable aerosol convention and a recently proposed alternative for low wind movement suggests that, while the existing inhalable aerosol convention remains appropriate for wind speeds above ∼0.2 m s(-1), the modified version is more appropriate for the range below ∼0.2 m s(-1).

  5. Proposed Modifications to Engineering Design Guidelines Related to Resistivity Measurements and Spacecraft Charging

    NASA Technical Reports Server (NTRS)

    Dennison, J. R.; Swaminathan, Prasanna; Jost, Randy; Brunson, Jerilyn; Green, Nelson; Frederickson, A. Robb

    2005-01-01

    A key parameter in modeling differential spacecraft charging is the resistivity of insulating materials. This determines how charge will accumulate and redistribute across the spacecraft, as well as the time scale for charge transport and dissipation. Existing spacecraft charging guidelines recommend use of tests and imported resistivity data from handbooks that are based principally upon ASTM methods that are more applicable to classical ground conditions and designed for problems associated with power loss through the dielectric, than for how long charge can be stored on an insulator. These data have been found to underestimate charging effects by one to four orders of magnitude for spacecraft charging applications. A review is presented of methods to measure the resistive of highly insulating materials, including the electrometer-resistance method, the electrometer-constant voltage method, the voltage rate-of-change method and the charge storage method. This is based on joint experimental studies conducted at NASA Jet Propulsion Laboratory and Utah State University to investigate the charge storage method and its relation to spacecraft charging. The different methods are found to be appropriate for different resistivity ranges and for different charging circumstances. A simple physics-based model of these methods allows separation of the polarization current and dark current components from long duration measurements of resistivity over day- to month-long time scales. Model parameters are directly related to the magnitude of charge transfer and storage and the rate of charge transport. The model largely explains the observed differences in resistivity found using the different methods and provides a framework for recommendations for the appropriate test method for spacecraft materials with different resistivities and applications. The proposed changes to the existing engineering guidelines are intended to provide design engineers more appropriate methods for

  6. Evaluation of dredged material proposed for ocean disposal from MOTBY

    SciTech Connect

    Barrows, E.S.; Mayhew, H.L.; Word, J.Q.

    1996-09-01

    The National Park Service, US Department of the Interior requested U.S. Army Corps of Engineers/New York District (USACE-NYD) to evaluate sediments around the Military Ocean Terminal (MOTBY) in Bayonne, New Jersey for unconfined ocean disposal at the Mud Dump Site. Sediment samples were collected from MOTBY. Tests and analyses were conducted on MOTBY sediment core samples. The evaluation of proposed dredged material from MOTBY included grain size and total organic carbon (TOC) analyses and one acute toxicity test with the amphipod Ampelisca abdita. In addition to this benthic toxicity test, a bioaccumulation test (28-day exposure) was conducted.

  7. Preliminary Field Evaluation of Mercury Control Using Combustion Modifications

    SciTech Connect

    V. Lissianski; P. Maly; T. Marquez

    2005-01-22

    In this project EER conducted a preliminary field evaluation of the integrated approach for mercury (Hg) and NO{sub x} control. The approach enhanced the 'naturally occurring' Hg capture by fly ash through combustion optimization, increasing carbon in ash content, and lowering ESP temperature. The evaluation took place in Green Station Units 1 and 2 located near Henderson, Kentucky and operated by Western Kentucky Energy. Units 1 and 2 are equipped with cold-side ESPs and wet scrubbers. Green Station Units 1 and 2 typically fire two types of fuel: a bituminous coal and a blend of bituminous coals based on availability. Testing of Hg emissions in Unit 2 without reburning system in operation and at minimum OFA demonstrated that efficiencies of Hg reduction downstream of the ESP were 30-40%. Testing also demonstrated that OFA system operation at 22% air resulted in 10% incremental increase in Hg removal efficiency at the ESP outlet. About 80% of Hg in flue gas at ESP outlet was present in the oxidized form. Testing of Hg emissions under reburning conditions showed that Hg emissions decreased with LOI increase and ESP temperature decrease. Testing demonstrated that maximum Hg reduction downstream of ESP was 40-45% at ESP temperatures higher than 300 F and 60-80% at ESP temperatures lower than 300 F. The program objective to demonstrate 80% Hg removal at the ESP outlet has been met.

  8. PRELIMINARY FIELD EVALUATION OF MERCURY CONTROL USING COMBUSTION MODIFICATIONS

    SciTech Connect

    Vitali Lissianski; Antonio Marquez

    2004-02-19

    In this project General Electric Energy and Environmental Research Corporation conducts a preliminary field evaluation of a novel technology, referred to as Hg/NO{sub x}, that can reduce emissions of both mercury (Hg) and oxides of nitrogen (NO{sub x}) from coal-fired power plants. The evaluation takes place in Green Station Unit 2 operated by Western Kentucky Energy. Reduction of Hg and NO{sub x} emissions in Unit 2 is achieved using coal reburning. Activities during first project year (January 23, 2003--January 22, 2004) included measurements of baseline Hg emissions in Unit 2 and pilot-scale testing. Baseline testing of Hg emissions in Green Unit 2 has been completed. Two fuels were tested with OFA system operating at minimum air flow. Mercury emissions were measured at ESP inlet and outlet, and at the stack using Ontario Hydro revised method. Testing demonstrated that baseline Hg reductions at ESP outlet and stack were 30-45% and 70-80%, respectively. Pilot-scale testing demonstrated good agreement with baseline measurements in Unit 2. Testing showed that fuel composition had an effect on the efficiency of Hg absorption on fly ash. Maximum achieved Hg removal in reburning was close to 90%. Maximum achieved Hg reduction at air staging conditions was 60%. Testing also demonstrated that lowering ESP temperature improved efficiency of Hg removal.

  9. Emergy evaluation perspectives of a multipurpose dam proposal in Korea.

    PubMed

    Kang, Daeseok; Park, Seok Soon

    2002-11-01

    The 'emergy' concept was used to evaluate the economy of Korea and the contributions of a multipurpose dam proposal to the real wealth of the Korean economy. Emergy is defined as the available energy of one kind previously used up directly and indirectly to make a product or service. The indices for Korea calculated from the emergy evaluation were close to those of developed countries. Even though its monetary balance of payments was negative in 1997, the economy of Korea showed positive balance in trade when exports and imports were expressed in emergy. The emergy evaluation showed that the Korean economy places a large stress on its environment. Water supply and generation of electricity were the most important contributions of the proposed dam in terms of emergy; 46.5 and 45.1% of the total benefit, respectively. Flood control contributed 8.4% of the total benefit. Major costs associated with the proposed dam were from sediments (33.2% of the total cost), construction services (22.8%), and social disruption of the region (21.6%). In terms of emergy, the ratio of benefits to costs of the proposed dam was 2.78 if sediments are not included, and 1.86 if sediments are included, which result in more benefits than costs in both cases. The benefit to cost ratio of the dam was larger than that of the current system (1.42) without the dam whether sediments are included in the total cost or not. The environmental stress of the proposed dam was considerably lower than that of the Korean economy, but the dam might increase stress on local environment.

  10. Motivational interviewing in dental hygiene education: curriculum modification and evaluation.

    PubMed

    Bray, Kimberly Krust; Catley, Delwyn; Voelker, Marsha A; Liston, Robin; Williams, Karen B

    2013-12-01

    Motivational interviewing (MI) is a person-centered, goal-directed method of communication for eliciting and strengthening intrinsic motivation for behavior change. Originally developed in the field of addiction therapy, MI has been increasing applied in the health professions with a growing body of successful outcomes for tobacco cessation and diabetic control, which can significantly impact oral health. MI has shown preliminary value for impacting oral behaviors that reduce early childhood caries, plaque, and gingival inflammation. While the training in and use of MI by oral health providers is emerging, full integration into dental and dental hygiene curricula has yet to be explored. Therefore, the purpose of this project was to evaluate the full implementation of MI in the classroom and clinic of a dental hygiene curriculum.

  11. Evaluation of proteomic search engines for the analysis of histone modifications.

    PubMed

    Yuan, Zuo-Fei; Lin, Shu; Molden, Rosalynn C; Garcia, Benjamin A

    2014-10-03

    Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118.

  12. Evaluation of Proteomic Search Engines for the Analysis of Histone Modifications

    PubMed Central

    2015-01-01

    Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118. PMID:25167464

  13. RBME coral temperature reconstruction: An evaluation, modifications, and recommendations

    NASA Astrophysics Data System (ADS)

    Sinclair, Daniel J.

    2015-04-01

    Rayleigh-Based Multi-Element (RBME) coral temperature reconstruction (Gaetani et al., 2011) is an important new method potentially allowing accurate ocean temperatures to be reconstructed from aragonitic corals without the need for in-situ calibration. RBME is based on a mathematical model which assumes that trace element uptake into coral skeleton is mediated by (1) temperature-dependent (inorganic) partition coefficients, and (2) a temperature-dependent change in the proportion of ions in a calcifying fluid that are precipitated as CaCO3. A time-series of Sr, Mg and Ba measurements can therefore be formulated as a set of simultaneous equations allowing temperatures and model fit-parameters to be solved numerically by least-squares minimization. Here, I critically review the RBME method, focusing on assumptions underlying the mathematical model, implementation of the numerical scheme, and the accuracy of temperature reconstruction. The equations in the RBME are highly nonlinear, and their number scales with the length of the time-series. These 'high-dimensional nonlinear optimization' problems are characterized by high computational cost, and the difficulty in finding the true 'global' minimum rather than false 'local' minima. Tests show that several of the RBME equations are highly sensitive to changing parameters thereby making it difficult for minimization algorithms to search broadly in parameter space. The method is therefore exceedingly slow and has a very strong tendency to find local optima that are close to the initial guess (which must be supplied by the user) making it very prone to 'operator bias'. Here a new formulation of the RBME system is proposed that allows much faster optimization, and a much broader search of parameter space. Testing of the RBME method reveals a number of problems. Firstly, RBME can produce many solutions to a given set of Sr, Mg and Ba data that are nearly identical in their minimization function (i.e., are equally good) but

  14. Evaluation of microscopic hematuria: a critical review and proposed algorithm.

    PubMed

    Niemi, Matthew A; Cohen, Robert A

    2015-07-01

    Microscopic hematuria (MH), often discovered incidentally, has many causes, including benign processes, kidney disease, and genitourinary malignancy. The clinician, therefore, must decide how intensively to investigate the source of MH and select which tests to order and referrals to make, aiming not to overlook serious conditions while simultaneously avoiding unnecessary tests. Existing professional guidelines for the evaluation of MH are largely based on expert opinion and have weak evidence bases. Existing data demonstrate associations between isolated MH and various diseases in certain populations, and these associations serve as the basis for our proposed approach to the evaluation of MH. Various areas of ongoing uncertainty regarding the appropriate evaluation should be the basis for ongoing research.

  15. Modification and performance evaluation of a mono-valve engine

    NASA Astrophysics Data System (ADS)

    Behrens, Justin W.

    A four-stroke engine utilizing one tappet valve for both the intake and exhaust gas exchange processes has been built and evaluated. The engine operates under its own power, but has a reduced power capacity than the conventional 2-valve engine. The reduction in power is traced to higher than expected amounts of exhaust gases flowing back into the intake system. Design changes to the cylinder head will fix the back flow problems, but the future capacity of mono-valve engine technology cannot be estimated. The back flow of exhaust gases increases the exhaust gas recirculation (EGR) rate and deteriorates combustion. Intake pressure data shows the mono-valve engine requires an advanced intake valve closing (IVC) time to prevent back flow of charge air. A single actuation camshaft with advanced IVC was tested in the mono-valve engine, and was found to improve exhaust scavenging at TDC and nearly eliminated all charge air back flow at IVC. The optimum IVC timing is shown to be approximately 30 crank angle degrees after BDC. The mono-valve cylinder head utilizes a rotary valve positioned above the tappet valve. The open spaces inside the rotary valveand between the rotary valve and tappet valve represent a common volume that needs to be reduced in order to reduce the base EGR rate. Multiple rotary valve configurations were tested, and the size of the common volume was found to have no effect on back flow but a direct effect on the EGR rate and engine performance. The position of the rotary valve with respect to crank angle has a direct effect on the scavenging process. Optimum scavenging occurs when the intake port is opened just after TDC.

  16. Forensic medical evaluations of child maltreatment: a proposed research agenda.

    PubMed

    Dubowitz, Howard; Christian, Cindy W; Hymel, Kent; Kellogg, Nancy D

    2014-11-01

    Physicians play an important role in the forensic evaluation of suspected child abuse and neglect. There has been considerable progress in the medical field, helping distinguish findings related to maltreatment from other conditions or circumstances. Nevertheless, important questions remain. This article covers several of these questions and proposes a research agenda concerning five main topics: sexual abuse, neglect, fractures, abusive head trauma, and physicians work in interdisciplinary settings. The suggestions are hardly inclusive, but offer suggestions the authors think are priorities, and ones that research could reasonably address. By providing some background to gaps in our knowledge, this paper should be of interest to a broader audience than just medical professionals.

  17. Quality framework proposal for Component Material Evaluation (CME) projects.

    SciTech Connect

    Christensen, Naomi G.; Arfman, John F.; Limary, Siviengxay

    2008-09-01

    This report proposes the first stage of a Quality Framework approach that can be used to evaluate and document Component Material Evaluation (CME) projects. The first stage of the Quality Framework defines two tools that will be used to evaluate a CME project. The first tool is used to decompose a CME project into its essential elements. These elements can then be evaluated for inherent quality by looking at the subelements that impact their level of quality maturity or rigor. Quality Readiness Levels (QRLs) are used to valuate project elements for inherent quality. The Framework provides guidance for the Principal Investigator (PI) and stakeholders for CME project prerequisites that help to ensure the proper level of confidence in the deliverable given its intended use. The Framework also Provides a roadmap that defined when and how the Framework tools should be applied. Use of these tools allow the Principal Investigator (PI) and stakeholders to understand what elements the project will use to execute the project, the inherent quality of the elements, which of those are critical to the project and why, and the risks associated to the project's elements.

  18. Evaluation of replacement protocols and modifications to TCP to enhance ASC Wide Area Network performance.

    SciTech Connect

    Romero, Randy L. Jr.

    2004-09-01

    Historically, TCP/IP has been the protocol suite used to transfer data throughout the Advanced Simulation and Computing (ASC) community. However, TCP was developed many years ago for an environment very different from the ASC Wide Area Network (WAN) of today. There have been numerous publications that hint of better performance if modifications were made to the TCP algorithms or a different protocol was used to transfer data across a high bandwidth, high delay WAN. Since Sandia National Laboratories wants to maximize the ASC WAN performance to support the Thor's Hammer supercomputer, there is strong interest in evaluating modifications to the TCP protocol and in evaluating alternatives to TCP, such as SCTP, to determine if they provide improved performance. Therefore, the goal of this project is to test, evaluate, compare, and report protocol technologies that enhance the performance of the ASC WAN.

  19. Physical evaluation system to determine medical risk and indicated dental therapy modifications.

    PubMed

    McCarthy, F M; Malamed, S F

    1979-08-01

    The physical evaluation system allows the practitioner to rapidly classify each patient according to medical risk and thus to provide dental treatment comfortably and safely. The evaluation system serves as a guide to the level of dental therapy, deisions of management, and modification of treatment for the medically compromised patient. Extensive use of the ADA physical status classification system in dentistry would allow meaningful studies of morbidity and mortality that are related to various management protocols and could conceivably have an impact on insurance schedules associated with psychosedation modalities and general anethesia on an out patient basis. A physical evaluation system cannot substitute for knowledge and good judgment. Recommended categories of physical status and modification of treatment should not be considered as absolutes, but as guides. Wheras the guidelines may appear to be inflexible, they should not be considered as such. Deviation from recommendations is often justified and is expected.

  20. Science Base and Tools for Evaluating Stream Restoration Project Proposals.

    NASA Astrophysics Data System (ADS)

    Cluer, B.; Thorne, C.; Skidmore, P.; Castro, J.; Pess, G.; Beechie, T.; Shea, C.

    2008-12-01

    Stream restoration, stabilization, or enhancement projects typically employ site-specific designs and site- scale habitat improvement projects have become the default solution to many habitat problems and constraints. Such projects are often planned and implemented without thorough consideration of the broader scale problems that may be contributing to habitat degradation, attention to project resiliency to flood events, accounting for possible changes in climate or watershed land use, or ensuring the long term sustainability of the project. To address these issues, NOAA Fisheries and USFWS have collaboratively commissioned research to develop a science document and accompanying tools to support more consistent and comprehensive review of stream management and restoration projects proposals by Service staff responsible for permitting. The science document synthesizes the body of knowledge in fluvial geomorphology and presents it in a way that is accessible to the Services staff biologists, who are not trained experts in this field. Accompanying the science document are two electronic tools: a Project Information Checklist to assist in evaluating whether a proposal includes all the information necessary to allow critical and thorough project evaluation; and a Project Evaluation Tool (in flow chart format) that guides reviewers through the steps necessary to critically evaluate the quality of the information submitted, the goals and objectives of the project, project planning and development, project design, geomorphic-habitat-species relevance, and risks to listed species. Materials for training Services staff and others in the efficient use of the science document and tools have also been developed. The longer term goals of this effort include: enabling consistent and comprehensive reviews that are completed in a timely fashion by regulators; facilitating improved project planning and design by proponents; encouraging projects that are attuned to their watershed

  1. Evaluation of materials proposed for use in space flight

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1981-01-01

    The primary irritancy and allergenicity of flame resistant treated cotton knit shirts proposed for use in space flight were evaluated. The knitted shirts were supplied by NASA as follows: knitted shirts with collars were made of two-ply mercerized single-knit cotton jersey. The fabric was treated with tetrakis (hydroxymethyl) phosphonium hydroxide and subsequently cured with gaseous ammonia (THPOH/NH3). The final treatment comprised adding on diammonium phosphate (DAP)/urea. The treated fabric was process scoured to remove extraneous materials, top softened and mechanically or chemically finished as required for specific needs. Diammonium phosphate is a more efficient flame inhabitant than the phosphonium; thus, the combination treatment served to impart higher resistance to ignition and sustained combustion as required by NASA test standard.

  2. Evaluating a Proposed 20% National Renewable Portfolio Standard

    SciTech Connect

    Logan, Jeffrey; Sullivan, Patrick; Short, Walter; Bird, Lori; James, Ted L.; Shah, Monisha R.

    2009-02-01

    This paper provides a preliminary analysis of the impacts of a proposed 20% national renewable portfolio standard (RPS) by 2021, which has been advanced in the U.S. Congress by Senator Jeff Bingaman of New Mexico. The paper was prepared before the America Recovery and Reinvestment Act was signed into law by President Barack Obama on February 17, 2009, and thus does not consider important changes in renewable energy (RE) policy that need to be addressed in follow-on analysis. We use NREL's Regional Energy Deployment System (ReEDS) model to evaluate the impacts of the RPS requirements on the energy sector and consider design issues associated with renewable energy certificate (REC) trading markets.

  3. Fiberoptic endoscopic evaluation of swallowing (FEES): proposal for informed consent

    PubMed Central

    Nacci, A; Ursino, F; La Vela, R; Matteucci, F; Mallardi, V; Fattori, B

    2008-01-01

    Summary Fiberoptic endoscopic evaluation of swallowing (FEES) is now a first choice method for studying swallowing disorders on account of the various advantages it offers: easy to use, very well tolerated, allows bedside examination and is economic. Nevertheless, this diagnostic procedure is not without risks, the most probable consequences of which include discomfort, gagging and/or vomiting, vasovagal syncope, epistaxis, mucosal perforation, adverse reactions to topical anaesthetics and laryngospasm. The risks involved with FEES stress the importance of informing the patient of these; this is an important aspect in medicine that necessarily and immediately implies receiving the patient’s so-called “informed consent”. Informed consent should be obtained not only by means of specific printed forms but also after the patient has had an interview with the physician who will be performing the procedure and who will offer information according to the personal clinical, psychological, cultural and linguistic situation of the patient and in keeping with the type of procedure proposed. In the case of FEES, as with other invasive or non-invasive diagnostic procedures, therefore, routine written and signed consent, together with a patient/physician interview should fulfil what is known as “complete information”. In this report, a specific form for informed consent to FEES procedures, is proposed. PMID:18939710

  4. 76 FR 27380 - Proposed Information Collection (Report of Medical Examination for Disability Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... AFFAIRS Proposed Information Collection (Report of Medical Examination for Disability Evaluation); Comment... opportunity for public comment on the proposed collection of certain information by the agency. Under the... Register concerning each proposed collection of information, including each proposed extension of...

  5. 75 FR 9279 - Proposed Information Collection (Survey of Satisfaction With the Disability Evaluation System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... AFFAIRS Proposed Information Collection (Survey of Satisfaction With the Disability Evaluation System (DES... announcing an opportunity for public comment on the proposed collection of certain information by the agency... Federal Register concerning each proposed collection of information, including each proposed...

  6. 78 FR 15739 - Notice of Lodging of Proposed Third Modification to Consent Decree Under the Clean Air Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... modification upon written request and payment of reproduction costs. Please mail your request and payment to... in the amount of $7.50 (25 cents per page reproduction cost) payable to the United States...

  7. Evaluation of Gene Modification Strategies for the Development of Low-Alcohol-Wine Yeasts

    PubMed Central

    Kutyna, D. R.; Solomon, M. R.; Black, C. A.; Borneman, A.; Henschke, P. A.; Pretorius, I. S.; Chambers, P. J.

    2012-01-01

    Saccharomyces cerevisiae has evolved a highly efficient strategy for energy generation which maximizes ATP energy production from sugar. This adaptation enables efficient energy generation under anaerobic conditions and limits competition from other microorganisms by producing toxic metabolites, such as ethanol and CO2. Yeast fermentative and flavor capacity forms the biotechnological basis of a wide range of alcohol-containing beverages. Largely as a result of consumer demand for improved flavor, the alcohol content of some beverages like wine has increased. However, a global trend has recently emerged toward lowering the ethanol content of alcoholic beverages. One option for decreasing ethanol concentration is to use yeast strains able to divert some carbon away from ethanol production. In the case of wine, we have generated and evaluated a large number of gene modifications that were predicted, or known, to impact ethanol formation. Using the same yeast genetic background, 41 modifications were assessed. Enhancing glycerol production by increasing expression of the glyceraldehyde-3-phosphate dehydrogenase gene, GPD1, was the most efficient strategy to lower ethanol concentration. However, additional modifications were needed to avoid negatively affecting wine quality. Two strains carrying several stable, chromosomally integrated modifications showed significantly lower ethanol production in fermenting grape juice. Strain AWRI2531 was able to decrease ethanol concentrations from 15.6% (vol/vol) to 13.2% (vol/vol), whereas AWRI2532 lowered ethanol content from 15.6% (vol/vol) to 12% (vol/vol) in both Chardonnay and Cabernet Sauvignon juices. Both strains, however, produced high concentrations of acetaldehyde and acetoin, which negatively affect wine flavor. Further modifications of these strains allowed reduction of these metabolites. PMID:22729542

  8. Evaluation of gene modification strategies for the development of low-alcohol-wine yeasts.

    PubMed

    Varela, C; Kutyna, D R; Solomon, M R; Black, C A; Borneman, A; Henschke, P A; Pretorius, I S; Chambers, P J

    2012-09-01

    Saccharomyces cerevisiae has evolved a highly efficient strategy for energy generation which maximizes ATP energy production from sugar. This adaptation enables efficient energy generation under anaerobic conditions and limits competition from other microorganisms by producing toxic metabolites, such as ethanol and CO(2). Yeast fermentative and flavor capacity forms the biotechnological basis of a wide range of alcohol-containing beverages. Largely as a result of consumer demand for improved flavor, the alcohol content of some beverages like wine has increased. However, a global trend has recently emerged toward lowering the ethanol content of alcoholic beverages. One option for decreasing ethanol concentration is to use yeast strains able to divert some carbon away from ethanol production. In the case of wine, we have generated and evaluated a large number of gene modifications that were predicted, or known, to impact ethanol formation. Using the same yeast genetic background, 41 modifications were assessed. Enhancing glycerol production by increasing expression of the glyceraldehyde-3-phosphate dehydrogenase gene, GPD1, was the most efficient strategy to lower ethanol concentration. However, additional modifications were needed to avoid negatively affecting wine quality. Two strains carrying several stable, chromosomally integrated modifications showed significantly lower ethanol production in fermenting grape juice. Strain AWRI2531 was able to decrease ethanol concentrations from 15.6% (vol/vol) to 13.2% (vol/vol), whereas AWRI2532 lowered ethanol content from 15.6% (vol/vol) to 12% (vol/vol) in both Chardonnay and Cabernet Sauvignon juices. Both strains, however, produced high concentrations of acetaldehyde and acetoin, which negatively affect wine flavor. Further modifications of these strains allowed reduction of these metabolites.

  9. Technical evaluation of proposed Ukrainian Central Radioactive Waste Processing Facility

    SciTech Connect

    Gates, R.; Glukhov, A.; Markowski, F.

    1996-06-01

    This technical report is a comprehensive evaluation of the proposal by the Ukrainian State Committee on Nuclear Power Utilization to create a central facility for radioactive waste (not spent fuel) processing. The central facility is intended to process liquid and solid radioactive wastes generated from all of the Ukrainian nuclear power plants and the waste generated as a result of Chernobyl 1, 2 and 3 decommissioning efforts. In addition, this report provides general information on the quantity and total activity of radioactive waste in the 30-km Zone and the Sarcophagus from the Chernobyl accident. Processing options are described that may ultimately be used in the long-term disposal of selected 30-km Zone and Sarcophagus wastes. A detailed report on the issues concerning the construction of a Ukrainian Central Radioactive Waste Processing Facility (CRWPF) from the Ukrainian Scientific Research and Design institute for Industrial Technology was obtained and incorporated into this report. This report outlines various processing options, their associated costs and construction schedules, which can be applied to solving the operating and decommissioning radioactive waste management problems in Ukraine. The costs and schedules are best estimates based upon the most current US industry practice and vendor information. This report focuses primarily on the handling and processing of what is defined in the US as low-level radioactive wastes.

  10. Flight evaluation of modifications to a digital electronic engine control system in an F-15 airplane

    NASA Technical Reports Server (NTRS)

    Burcham, F. W., Jr.; Myers, L. P.; Zeller, J. R.

    1983-01-01

    The third phase of a flight evaluation of a digital electronic engine control system in an F-15 has recently been completed. It was found that digital electronic engine control software logic changes and augmentor hardware improvements resulted in significant improvements in engine operation. For intermediate to maximum power throttle transients, an increase in altitude capability of up to 8000 ft was found, and for idle to maximum transients, an increase of up to 4000 ft was found. A nozzle instability noted in earlier flight testing was investigated on a test engine at NASA Lewis Research Center, a digital electronic engine control software logic change was developed and evaluated, and no instability occurred in the Phase 3 flight evaluation. The backup control airstart modification was evaluated, and gave an improvement of airstart capability by reducing the minimum airspeed for successful airstarts by 50 to 75 knots.

  11. Sustainable urban housing in Kathmandu, Nepal: Proposals and evaluations

    NASA Astrophysics Data System (ADS)

    Shrestha, Vikas

    quantifies the embodied energy of basic building materials that are used in Nepal; proposes new types of locally-produced insulation; and develops a sustainable design evaluation system based on LEED. This integrated system of sustainable materials database, evaluation system, and vernacular-based housing prototypes developed in this dissertation lays out an example for other third world countries.

  12. Technical evaluation of the CG-47201 6V-92 detroit diesel electronic control (DDEC) propulsion modification. Final report

    SciTech Connect

    Latas, R.M.

    1995-03-01

    This report describes the testing and evaluation (TE) of the CG-47201 6V-92 DDEC Propulsion Modification that was conducted at Coast Guard Station Cape May, New Jersey, during the period 8-12 November 1994.

  13. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... Physical size, concentration of industry, and economic significance of the service region's manufacturing... categories. (1) Identification of target firms in proposed region. Does the proposal define an appropriate service region with a large enough population of target firms of small- and medium-sized...

  14. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... categories. (1) Identification of target firms in proposed region. Does the proposal define an appropriate service region with a large enough population of target firms of small- and medium-sized manufacturers... operating and capital costs guaranteed by the applicant. Identification of matching fund sources and...

  15. Evaluating Federal Water Projects: A Critique of Proposed Standards

    ERIC Educational Resources Information Center

    Cicchetti, Charles J.; And Others

    1973-01-01

    Questions the feasibility of, and validity of the concepts behind, some of the new procedures proposed by the Water Resources Council. Concludes that the proposed procedures, if accepted in their present form, will bias water resource management in favor of development and against the preservation of the natural environment. (JR)

  16. Proposed 237U Evaluation for the next ENDL Release

    SciTech Connect

    Brown, D; Summers, N; Thompson, I; Younes, W

    2007-11-07

    We detail the new LLNL evaluation of {sup 237}U for inclusion in both the next release of the ENDL and ENDF/B-VII databases. This evaluation is based on a combination of TALYS calculations, data fits and the earlier JEFF-3.1 evaluation. Our evaluation is in excellent agreement with published surrogate (n, f) data [11, 12, 13, 14, 18] and the unpublished LLNL surrogate (n,2n) data [16].

  17. Evaluation of cloud shading effects on the generation and modification of mesoscale circulations

    NASA Technical Reports Server (NTRS)

    Segal, M.; Song, J. L.; Pielke, R. A.; Purdom, J. F. W.; Mahrer, Y.

    1986-01-01

    This study presents scale analysis and numerical model evaluations of the impact of cloud shading on (1) the development of sea breeze and thermally induced upslope flows and (2) the generation of mesoscale circulations between cloudy areas adjacent to clear areas. Based on the assumption of modifications of solar and longwave radiation which are typical for some overcast conditions, it was found that the reduction in the first type of circulation is significant and most noticeable in the vertical velocities. In the second case, thermally induced circulations in favorable conditions appear to approach the typical intensity of the sea breeze.

  18. 77 FR 42462 - Hawaii State Plan for Occupational Safety and Health; Proposed Modification of 18(e) Plan Approval

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-19

    ... Administration (OSHA), Department of Labor. ACTION: Notice of opportunity to request informal public hearing... Relations has requested a temporary modification of the state plan's approval status from final approval to... Assistant Secretary during this proceeding. Members of the public may also submit requests for an...

  19. Reduced thrombogenicity of nitinol stents--in vitro evaluation of different surface modifications and coatings.

    PubMed

    Tepe, Gunnar; Schmehl, Joerg; Wendel, Hans P; Schaffner, Sivio; Heller, Stephan; Gianotti, Marc; Claussen, Claus D; Duda, Stephan H

    2006-02-01

    The material and the surface patterns of intravascular stents play a pivotal role in activating platelets and triggering adherence of inflammatory cells that consecutively leads to renarrowing caused by neointimal hyperplasia. To improve these features, besides mechanical and chemical modifications, ways of masking the stent by covering have been developed. In addition, polymer-coated stents are used as vehicle for local drug delivery. But as substances used for this application are described to possess an inflammatory potential, this aspect has to be evaluated. In the present study we compared different approaches to surface alterations applied to a nitinol stent design. Besides commonly used techniques like passivation and electropolishing, we evaluated coatings with heparin, aluminium and a polyurethane polymer regarding their thrombogenic and inflammatory characteristics. By weaving thin elastomer fibres a graft was generated. The previously described Chandler loop was used to simulate arterial flow conditions ex vivo using rotating PVC tubings filled with human blood. All stents received 120 min of blood contact. To determine thrombocyte activation and inflammatory reaction, the platelet count and levels of beta-TG, TAT and PMN-elastase were assessed. Scanning electron microscopy was used to visualize the reactions. Mechanical polishing and passivation did not improve the stent surface characteristics while sandblasting, electropolishing and aluminium covering decreased activation of the coagulation cascade. In terms of thrombogenicity, the heparin coating had no beneficial effect. The lowest thrombogenic potential was found in the Polyurethane-coated stent group. All stents showed similar levels of polymorph nuclear granulocyte elastase except for the membrane design. While mechanical and chemical modifications are able to reduce thrombogenicity, coating with this particular polyurethane polymer seems to be superior to these approaches regarding the

  20. Proposed modifications to the RCRA post-closure permit for the Bear Creek Hydrogeologic Regime at the US Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to several conditions of the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Bear Creek Hydrogeologic Regime (BCHR). These permit conditions define the requirements for RCRA post-closure corrective action groundwater monitoring at the S-3 Ponds, the Oil Landfarm, and the Bear Creek Burial Grounds (units A, C-West, and Walk-in Pits). Modification of these PCP conditions is requested to: (1) clarify the planned integration of RCRA post-closure corrective action groundwater monitoring with the monitoring program to be established in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Record of Decision (ROD) for the Bear Creek Valley (BCV) Watershed, (2) revise several of the current technical requirements for groundwater monitoring based on implementation of the RCRA post-closure corrective action monitoring program during 1996, and (3) update applicable technical procedures with revised versions recently issued by the Y-12 Plant Groundwater Protection Program (GWPP). With these modifications, the Y-12 Plant will continue to meet the full intent of all regulatory obligations for post-closure care of these facilities. Section 2.0 provides the technical justification for each proposed permit modification. The proposed changes to permit language are provided in Section 3.0 (S-3 Ponds), Section 4.0 (Oil Landfarm), and Section 5.0 (Bear Creek Burial Grounds). Sections 6.0 and 7.0 reference updated and revised procedures for groundwater sampling, and monitoring well plugging and abandonment, respectively. Appendix A includes all proposed revisions to the PCP Attachments.

  1. CRITERIA FOR EVALUATION OF PROPOSED PROTOZOAN DETECTION METHODS

    EPA Science Inventory

    There has been a proliferation of techniques and methods reported for analysis of water samples to determine the presence of the protozoan pathogens Cryptosporidium parvum and Giardia lamblia. Many of the proposed methods are presented as complete procedures, which include sampli...

  2. CRITERIA FOR EVALUATION OF PROPOSED PROTOZOAN DETECTION METHODS.

    EPA Science Inventory

    There has been a proliferation of techniques and methods reported for analysis of water samples to determine the presence of the protozoan pathogens Cryptosporidium parvum and Giardia lamblia. Many of the proposed methods are presented as complete procedures, which include sampli...

  3. 76 FR 18615 - 30-Day Notice of Proposed Information Collection: Performance Measurement, Evaluation and Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... Notice of Proposed Information Collection: Performance Measurement, Evaluation and Public Diplomacy... Reduction Act of 1995. Title of Information Collection: Performance Measurement, Evaluation and Public... performance measurement, evaluation and customer satisfaction surveys. Included in this request is...

  4. 77 FR 6168 - 60-Day Notice of Proposed Information Collection: English Language Evaluation Surveys, OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Notice of Proposed Information Collection: English Language Evaluation Surveys, OMB Control Number 1405... Information Collection: English Language Evaluation: Fulbright English Teaching Assistantship (ETA) Program...: Voluntary. Title of Information Collection: English Language Evaluation: English Language Specialist...

  5. 76 FR 33395 - 30-Day Notice of Proposed Information Collections: ECA Sports & Culture Evaluation Surveys

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... Notice of Proposed Information Collections: ECA Sports & Culture Evaluation Surveys ACTION: Notice of... Information Collection: Sports & Culture Evaluation, Between the Lines (BTL) Survey. OMB Control Number: None... Respond: Voluntary. Title of Information Collection: Sports & Culture Evaluation, Sports Envoys...

  6. Evaluation of exercise-respiratory system modifications and integration schemes for physiological systems

    NASA Technical Reports Server (NTRS)

    Gallagher, R. R.

    1974-01-01

    Exercise subroutine modifications are implemented in an exercise-respiratory system model yielding improvement of system response to exercise forcings. A more physiologically desirable respiratory ventilation rate in addition to an improved regulation of arterial gas tensions and cerebral blood flow is observed. A respiratory frequency expression is proposed which would be appropriate as an interfacing element of the respiratory-pulsatile cardiovascular system. Presentation of a circulatory-respiratory system integration scheme along with its computer program listing is given. The integrated system responds to exercise stimulation for both nonstressed and stressed physiological states. Other integration possibilities are discussed with respect to the respiratory, pulsatile cardiovascular, thermoregulatory, and the long-term circulatory systems.

  7. Evaluation of textiles proposed for spacecraft crew apparel

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1976-01-01

    Textiles proposed for spacecraft wearing apparel were tested for possible primary irritancy and allergenicity using guinea pigs and human subjects. The materials submitted for testing were: (1) blue, loosely knit fabric of a copolymer of chlorotrifluoroethylene and ethylene (CTFE), (2) a white fabric, 100% cotton double knit, treated with fire retardant Tetrakis (hydroxymethyl) phosphonium hydroxide/ammonia, and (3) a gold colored polyimide fabric. There were no adverse reactions to any of the fabrics.

  8. 7 CFR 3406.20 - Evaluation criteria for research proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... resources? 15 points. (c) Institutional capacity building: This criterion relates to the degree to which the... FOOD AND AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Review and Evaluation of a... knowledge constituting the natural and social sciences undergirding the agricultural, natural resources,...

  9. 7 CFR 3406.20 - Evaluation criteria for research proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... resources? 15 points. (c) Institutional capacity building: This criterion relates to the degree to which the... FOOD AND AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Review and Evaluation of a... knowledge constituting the natural and social sciences undergirding the agricultural, natural resources,...

  10. 7 CFR 3406.20 - Evaluation criteria for research proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... resources? 15 points. (c) Institutional capacity building: This criterion relates to the degree to which the... FOOD AND AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Review and Evaluation of a... knowledge constituting the natural and social sciences undergirding the agricultural, natural resources,...

  11. 7 CFR 3406.20 - Evaluation criteria for research proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... resources? 15 points. (c) Institutional capacity building: This criterion relates to the degree to which the... FOOD AND AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Review and Evaluation of a... knowledge constituting the natural and social sciences undergirding the agricultural, natural resources,...

  12. 48 CFR 1515.305-71 - Documentation of proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... evaluation documentation shall include: (a) Score sheets prepared by each individual team member must be made... specifically developed for the solicitation; and (b) A statement that the respective team members are free from actual or potential personal conflicts of interest, and are in compliance with the Office of...

  13. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL.... (a) In making a decision whether to provide financial support, NIST shall review and evaluate all... NIST research results and expertise in the technical areas noted in these procedures? (3)...

  14. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL.... (a) In making a decision whether to provide financial support, NIST shall review and evaluate all... NIST research results and expertise in the technical areas noted in these procedures? (3)...

  15. Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations.

    PubMed Central

    Rodwell, J D; Alvarez, V L; Lee, C; Lopes, A D; Goers, J W; King, H D; Powsner, H J; McKearn, T J

    1986-01-01

    A strategy for covalent modification of monoclonal antibodies utilizing the oxidized oligosaccharide moieties on the molecule was evaluated and compared to more conventional methods. As judged by quantitative in vitro measurements, a monoclonal antibody conjugate prepared via the oligosaccharides retained the homogeneous antigen binding property and affinity of the unmodified antibody. In contrast, conjugates of the same antibody, modified to the same degree on either lysines or aspartic and glutamic acid side chains, were heterogeneous in their antigen binding and had lowered affinity. In vivo biodistribution and nuclear-imaging experiments were also performed with a second monoclonal antibody and a tumor xenograft model. Antibodies modified on the oligosaccharides with either a peptide labeled with iodine-125 or a diethylenetriaminepentaacetic acid chelate with indium-111 localize into target tumors more efficiently than the same antibody radiolabeled on either tyrosines or lysines. These in vivo results, when compared to those reported in the literature for conventionally modified antibodies, suggest that oligosaccharide modification of monoclonal antibodies is a preferred method of preparing conjugates. Images PMID:3458222

  16. 76 FR 40293 - Proposed Amendment of Class D and Modification of Class E Airspace; Grand Junction, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... Airspace; Grand Junction, CO AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to modify Class E airspace at Grand Junction Regional Airport, Grand Junction, CO. Additional controlled airspace is necessary to facilitate vectoring...

  17. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... evaluate proposals and select the best one? 51.16 Section 51.16 Parks, Forests, and Public Property... Procedures § 51.16 How will the Director evaluate proposals and select the best one? (a) The Director will apply the selection factors set forth in § 51.17 by assessing each timely proposal under each of...

  18. 15 CFR 400.26 - Criteria for evaluation of applications for expansions, subzones or other modifications of zones.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Criteria for evaluation of applications for expansions, subzones or other modifications of zones. 400.26 Section 400.26 Commerce and... Authority § 400.26 Criteria for evaluation of applications for expansions, subzones or other...

  19. 15 CFR 400.26 - Criteria for evaluation of applications for expansions, subzones or other modifications of zones.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Criteria for evaluation of applications for expansions, subzones or other modifications of zones. 400.26 Section 400.26 Commerce and... Authority § 400.26 Criteria for evaluation of applications for expansions, subzones or other...

  20. 23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Guidance Criteria for Evaluating Requests for Modifications to the National Highway System D Appendix D to Subpart A of Part 470 Highways FEDERAL HIGHWAY.... 470, Subpt. A, App. D Appendix D to Subpart A of Part 470—Guidance Criteria for Evaluating...

  1. Modification and evaluation of a Barnes-type objective analysis scheme for surface meteorological data

    NASA Technical Reports Server (NTRS)

    Smith, D. R.

    1982-01-01

    The Purdue Regional Objective Analysis of the Mesoscale (PROAM) is a Barness-type scheme for the analysis of surface meteorological data. Modifications are introduced to the original version in order to increase its flexibility and to permit greater ease of usage. The code was rewritten for an interactive computer environment. Furthermore, a multiple iteration technique suggested by Barnes was implemented for greater accuracy. PROAM was subjected to a series of experiments in order to evaluate its performance under a variety of analysis conditions. The tests include use of a known analytic temperature distribution in order to quantify error bounds for the scheme. Similar experiments were conducted using actual atmospheric data. Results indicate that the multiple iteration technique increases the accuracy of the analysis. Furthermore, the tests verify appropriate values for the analysis parameters in resolving meso-beta scale phenomena.

  2. Evaluation of an interprofessional team-based learning nutrition and lifestyle modification course.

    PubMed

    Pogge, Elizabeth

    2016-01-01

    An interprofessional, team-based learning elective was developed, implemented, and evaluated to determine the knowledge gained, attitude changes towards interprofessional education, and overall satisfaction with the course. Thirty participants, 14 osteopathic medicine students and 16 pharmacy students, completed the course. The majority of students (88-96%) responded favourably to the team-based learning aspects of the course. Knowledge about nutrition and lifestyle modification was significantly improved by taking the course. Overall, students' readiness for and perception of interprofessional learning improved by taking the course, although not all improvements were statistically significant. In conclusion, the benefits of team-based learning, such as enhancing communication and teamwork skills, can enhance interprofessional education.

  3. Ecological evaluation of proposed dredged material from Richmond Harbor

    SciTech Connect

    Pinza, M R; Ward, J A; Mayhew, H L; Word, J Q; Niyogi, D K; Kohn, N P

    1992-10-01

    During the summer of 1991, Battelle/Marine Sciences Laboratory (MSL) was contracted to conduct sampling and testing of sediments proposed for dredging of Richmond Harbor, California. The MSL collected sediment cores to a depth of [minus]40 ft MLLW ([minus]38 ft + 2 ft overdepth) from 28 (12-in. core) and 30 (4-in. core) stations. The sediment cores were allocated to six composite samples referred to as sediment treatments, which were then subjected to physical, chemical, toxicological, and bioaccumulation testing. Physical and chemical parameters included grain size, total organic carbon (TOC), total volatile solids (TVS), oil and grease, total petroleum hydrocarbons (TPH), polynuclear aromatic hydrocarbons (PAH), chlorinated pesticides, polychlorinated biphenyis (PCBs), priority pollutant metals, and butyltins. The results from the test treatments were compared to results from five reference treatments representative of potential in-bay and offshore disposal sites.

  4. Ecological evaluation of proposed dredged material from Richmond Harbor

    SciTech Connect

    Pinza, M.R.; Ward, J.A.; Mayhew, H.L.; Word, J.Q.; Niyogi, D.K.; Kohn, N.P.

    1992-10-01

    During the summer of 1991, Battelle/Marine Sciences Laboratory (MSL) was contracted to conduct sampling and testing of sediments proposed for dredging of Richmond Harbor, California. The MSL collected sediment cores to a depth of {minus}40 ft MLLW ({minus}38 ft + 2 ft overdepth) from 28 (12-in. core) and 30 (4-in. core) stations. The sediment cores were allocated to six composite samples referred to as sediment treatments, which were then subjected to physical, chemical, toxicological, and bioaccumulation testing. Physical and chemical parameters included grain size, total organic carbon (TOC), total volatile solids (TVS), oil and grease, total petroleum hydrocarbons (TPH), polynuclear aromatic hydrocarbons (PAH), chlorinated pesticides, polychlorinated biphenyis (PCBs), priority pollutant metals, and butyltins. The results from the test treatments were compared to results from five reference treatments representative of potential in-bay and offshore disposal sites.

  5. Evaluation of Grid Modification Methods for On- and Off-Track Sonic Boom Analysis

    NASA Technical Reports Server (NTRS)

    Nayani, Sudheer N.; Campbell, Richard L.

    2013-01-01

    Grid modification methods have been under development at NASA to enable better predictions of low boom pressure signatures from supersonic aircraft. As part of this effort, two new codes, Stretched and Sheared Grid - Modified (SSG) and Boom Grid (BG), have been developed in the past year. The CFD results from these codes have been compared with ones from the earlier grid modification codes Stretched and Sheared Grid (SSGRID) and Mach Cone Aligned Prism (MCAP) and also with the available experimental results. NASA's unstructured grid suite of software TetrUSS and the automatic sourcing code AUTOSRC were used for base grid generation and flow solutions. The BG method has been evaluated on three wind tunnel models. Pressure signatures have been obtained up to two body lengths below a Gulfstream aircraft wind tunnel model. Good agreement with the wind tunnel results have been obtained for both on-track and off-track (up to 53 degrees) cases. On-track pressure signatures up to ten body lengths below a Straight Line Segmented Leading Edge (SLSLE) wind tunnel model have been extracted. Good agreement with the wind tunnel results have been obtained. Pressure signatures have been obtained at 1.5 body lengths below a Lockheed Martin aircraft wind tunnel model. Good agreement with the wind tunnel results have been obtained for both on-track and off-track (up to 40 degrees) cases. Grid sensitivity studies have been carried out to investigate any grid size related issues. Methods have been evaluated for fully turbulent, mixed laminar/turbulent and fully laminar flow conditions.

  6. Evaluation of proposed Skylab and SSP soap products.

    NASA Technical Reports Server (NTRS)

    Durfee, R. L.; Spurlock, J. M.; Whitmore, F. C.

    1973-01-01

    Four candidate cleansing agents evaluated in terms of potential hazards to crew members included two soaps (Neutrogena bar soap and Olive Leaf Liquid), one nonfoaming surfactant (Miranol JEM), and one laundry detergent (sodium dodecylbenzene sulfonate). None of the four exhibited adverse dermatological effects from skin patch tests or supported growth of potentially pathogenic microorganisms. Aqueous solutions of Neutrogena did support a mold species. Neutrogena and Miranol JEM were used in a simulated Skylab personal hygiene regimen with no adverse effects on skin or skin microflora. Based on our results, each of these agents appear to be a promising candidate material for the use intended.

  7. School violence: evaluation and proposal of teaching staff.

    PubMed

    Domínguez Alonso, José; López-Castedo, Antonio; Pino Juste, Margarita

    2009-10-01

    The aim of this work was to evaluate the frequency of violent behaviors in educational centers, according to self-report of the teaching staff. To that end, a questionnaire about school violence was administered to a sample of 616 teachers working in primary and secondary schools in Galicia, Spain. Disruptive and antisocial behaviors in the student population were reported to affect the teaching effort negatively. The compiled data indicate verbal aggression is the most common form of violence used by the student population and reveal the dissatisfaction of teaching staff not prepared for this challenge. Teachers felt the need to devise new effective responses to promote concord in educational communities.

  8. Two-Dimensional Hydrodynamic Modeling and Analysis of the Proposed Channel Modifications and Grade Control Structure on the Blue River near Byram's Ford Industrial Park, Kansas City, Missouri

    USGS Publications Warehouse

    Huizinga, Richard J.

    2007-01-01

    The Blue River Channel Modification project being implemented by the U.S. Army Corps of Engineers (USACE) is intended to provide flood protection within the Blue River valley in the Kansas City, Mo., metropolitan area. In the latest phase of the project, concerns have arisen about preserving the Civil War historic area of Byram's Ford and the associated Big Blue Battlefield while providing flood protection for the Byram's Ford Industrial Park. In 1996, the USACE used a physical model built at the Waterways Experiment Station (WES) in Vicksburg, Miss., to examine the feasibility of a proposed grade control structure (GCS) that would be placed downstream from the historic river crossing of Byram's Ford to provide a subtle transition of flow from the natural channel to the modified channel. The U.S. Geological Survey (USGS), in cooperation with the USACE, modified an existing two-dimensional finite element surface-water model of the river between 63d Street and Blue Parkway (the 'original model'), used the modified model to simulate the existing (as of 2006) unimproved channel and the proposed channel modifications and GCS, and analyzed the results from the simulations and those from the WES physical model. Modifications were made to the original model to create a model that represents existing (2006) conditions between the north end of Swope Park immediately upstream from 63d Street and the upstream limit of channel improvement on the Blue River (the 'model of existing conditions'). The model of existing conditions was calibrated to two measured floods. The model of existing conditions also was modified to create a model that represents conditions along the same reach of the Blue River with proposed channel modifications and the proposed GCS (the 'model of proposed conditions'). The models of existing conditions and proposed conditions were used to simulate the 30-, 50-, and 100-year recurrence floods. The discharge from the calibration flood of May 15, 1990, also

  9. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed...

  10. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed...

  11. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed...

  12. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed...

  13. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed...

  14. Preliminary evaluation of a proposed injection site in Mellones

    SciTech Connect

    Ortiz, N.V.; Rada, H.M.

    1996-08-01

    A hydrogeological evaluation was carried out in the Melones area to determine the feasibility of disposing brackish water and brines associated with oil production activities. The region is located towards north-central Hamaca, in the Anzoategui state, and covers an area of approximately 454 km{sup 2}. The study was based on the examination and interpretation of available stratigraphic and structural maps, well logs and formation water analysis. Engineering properties were estimated from 42 wells, selected from a total of 575 wells, where complete sets of well logs were available. The most suitable injection interval, integrated by the 02/3, D1-D2-D3-D4 and E1-E2 sands from the upper part of the Oficina Formation, was selected by addressing certain technical requirements for suitable potential disposal sites and injection intervals. A two-dimensional finite difference flow model was used to simulate the long-term hydraulic head buildup under projected operating conditions. After examination of the important characteristics considered in the evaluation process, it appears that the Melones area favorably meets most criteria.

  15. 7 CFR 1487.6 - What are the criteria for evaluating proposals?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... potential trade impact of the proposed project on market retention, market access, and market expansion... evaluate each proposal against the factors described in paragraph (a) of this section. The purpose of...

  16. 78 FR 35942 - Proposed Collection; Comment Request: Palliative Care: Conversations Matter Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request: Palliative Care.... Proposed Collection Palliative Care: Conversations Matter Evaluation -0925--New--National Institute of... developed Palliative Care: Conversations Matter, a pediatric palliative care campaign to address...

  17. 7 CFR 1487.6 - What are the criteria for evaluating proposals?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... barrier; (2) The potential trade impact of the proposed project on market retention, market access, and... completeness and will evaluate each proposal against the factors described in paragraph (a) of this...

  18. 77 FR 31584 - Proposed Information Collection; Comment Request; Generic Clearance for Program Evaluation Data...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... National Institute of Standards and Technology Proposed Information Collection; Comment Request; Generic Clearance for Program Evaluation Data Collection AGENCY: National Institute of Standards and Technology... take this opportunity to comment on proposed and/or continuing information collections, as required...

  19. Evaluation of materials proposed for use in space flight

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1981-01-01

    The cutaneous primary irritancy and allergenicity potential of cotton shirts/fabrics treated with flame retardants were evaluated in order to establish their suitability for spacecraft crew use. Twenty-five volunteer human subjects were patch tested on the back utilizing standard methodology, with both treated and untreated cotton fabric. The fabric was treated with tetrakis (hydroxymethyl) phosphonium hydroxide and subsequently cured with gaseous ammonia. The final treatment comprised adding on dicyandiamine phosphoric acid. None of the individuals experienced primary irritant or allergic reactions attributable to the fabric during induction or challenge patch testing. Likewise, there were no reactions to treated or untreated fabric patches placed on ten subjects of the usage panel at the conclusion of the study.

  20. Evaluation of proposed Skylab and SSP soap products

    NASA Technical Reports Server (NTRS)

    Whitmore, F. C.; Durfee, R. L.; Spurlock, J. M.

    1973-01-01

    Three personal hygiene cleansing agents and one laundry detergent (sodium dodecyl benzene sulfonate), which are all candidates for use on long-duration space missions, were evaluated in terms of dermatological effects on human subjects and effects on microbiological species. None of the four materials exhibited adverse dermatological effects from either skin patch tests of two weeks duration or a simulated Skylab personal hygiene regimen of up to four weeks duration. No significant alterations in skin microflora during the use regimen were found. None of the four materials were found to serve as microbiological support media for the species tested, but a species of air-borne mold was observed to grow rapidly in a neutralized aqueous solution. None of the candidate agents was found to be strongly biocidal.

  1. Hazardous-waste nightmare. [Evaluation of legislative proposals

    SciTech Connect

    Alexander, T.

    1980-04-21

    Mr. Alexander points out that, even in the absence of Federal regulation, hazardous wastes would be a major problem for companies. Many have been driven to desperate measures even to find someplace to put the 125 billion pounds of such wastes that are produced each year - but that nobody wants nearby. EPA recently began promulgating final regulations implementing the Resource Conservation and Recovery Act passed by Congress in 1976; these regulations will mandate technical standards for all future waste sites as well as a cradle to grave system for tracking major hazardous wastes to their ultimate disposition. But much of Washington's new interest seems to be a response to the charge that government too long overlooked the menace in old wastes; so, they are now turning to unusually primitive measures aimed at industry's past practice. The Justice Department has mobilized a fourteen-lawyer section to track down and prosecute companies for transgressions. Several bills are making their way through committees and, if enacted, could confront even very large industries with the choice of finding some new way of dealing with old wastes or going out of business. In discussing these proposals and touching briefly on the technical side of how wastes reach the aquifers, Mr. Alexander says that little is known about the extent of trace-chemical contamination - and, although it's time Washington ended its neglect of the problem, the extremely punitive measures are probably not called for.

  2. 76 FR 57767 - Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for... NRC Generic Letter 2011- XX: Seismic Risk Evaluations for Operating Reactors. This action is...

  3. 77 FR 61446 - Proposed Revision Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... COMMISSION Proposed Revision Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors..., ``Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors.'' DATES: Submit comments by... accident assessments for new reactors submitted to support design certification (DC) and combined...

  4. 77 FR 12322 - Notice of Submission of Proposed Information Collection to OMB; Evaluation of the Veterans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... Veterans Homelessness Prevention Demonstration AGENCY: Office of the Chief Information Officer, HUD. ACTION... information required to evaluate the Veterans Homelessness Prevention Demonstration (VHPD). The Department... following information: Title of Proposal: Evaluation of the Veterans Homelessness Prevention...

  5. 77 FR 54860 - Proposed Modification of VOR Federal Airway V-170 in the Vicinity of Devils Lake, ND

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... newly established restricted area R-5402, Devils Lake, ND, to support non- radar separation requirements... separation requirements. Their request proposed the new airway use the DVL VOR 180 (M) and JMS VOR 327 (M) radials to provide the required non-radar separation and airway clearance from R- 5402, regardless of...

  6. 78 FR 32617 - Proposed Modification of Significant New Uses of 1-Propene, 2,3,3,3-tetrafluoro-

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... originally charged with the refrigerant by the motor vehicle original equipment manufacturer (OEM) no longer... systems originally charged with the PMN substance by the motor vehicle OEM is not a significant new use of... the motor vehicle OEM. V. Economic Analysis EPA evaluated the potential costs of establishing...

  7. 45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of research support: Evaluation of applications and proposals. (a) The department or agency head may... 45 Public Welfare 3 2010-10-01 2010-10-01 false Early termination of research support: Evaluation of applications and proposals. 690.123 Section 690.123 Public Welfare Regulations Relating to...

  8. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Evaluating proposals of foreign iron, steel... American Recovery and Reinvestment Act of 2009 § 176.110 Evaluating proposals of foreign iron, steel, and... cost of certain domestic iron, steel, and/or manufactured goods being unreasonable, in accordance...

  9. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Evaluating proposals of foreign iron, steel... Evaluating proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured...

  10. 23 CFR 636.301 - How should proposal evaluation factors be selected?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false How should proposal evaluation factors be selected? 636.301 Section 636.301 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal Evaluation Factors § 636.301 How...

  11. 23 CFR 636.301 - How should proposal evaluation factors be selected?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false How should proposal evaluation factors be selected? 636.301 Section 636.301 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal Evaluation Factors § 636.301 How...

  12. 77 FR 69539 - 30-Day Notice of Proposed Information Collection: Humphrey Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... Notice of Proposed Information Collection: Humphrey Evaluation Survey ACTION: Notice of request for public comment and submission to OMB of proposed collection of information. SUMMARY: The Department of... Information Collection: Humphrey Evaluation Survey. OMB Control Number: None. Type of Request: New...

  13. Evaluation of exercise-respiratory system modifications and preliminary respiratory-circulatory system integration scheme

    NASA Technical Reports Server (NTRS)

    Gallagher, R. R.

    1974-01-01

    The respiratory control system, functioning as an independent system, is presented with modifications of the exercise subroutine. These modifications illustrate an improved control of ventilation rates and arterial and compartmental gas tensions. A very elementary approach to describing the interactions of the respiratory and circulatory system is presented.

  14. Clinical evaluation of multimodal environmental modification (MEMO) in the management of cats with idiopathic cystitis.

    PubMed

    Buffington, C A Tony; Westropp, Jodi L; Chew, Dennis J; Bolus, Roger R

    2006-08-01

    This prospective observational study evaluated client-reported recurrence of lower urinary tract signs (LUTS) and other signs of abnormalities in cats with idiopathic cystitis after institution of multimodal environmental modification (MEMO). Forty-six client-owned indoor-housed cats with idiopathic cystitis, diagnosed based on a history of recurrent LUTS and evidence of absence of urolithiasis or bacterial urinary tract infection were studied. In addition to their usual care, clients were offered recommendations for MEMO based on a detailed environmental history. Cases were followed for 10 months by client contact to determine the effect of MEMO on LUTS and other signs. Significant (P<0.05) reductions in LUTS, fearfulness, nervousness, signs referable to the respiratory tract, and a trend (P<0.1) toward reduced aggressive behavior and signs referable to the lower intestinal tract were identified. These results suggest that MEMO is a promising adjunctive therapy for indoor-housed cats with LUTS, and should be followed up with prospective controlled clinical trials.

  15. Enzymatic modification of palmarosa essential oil: chemical analysis and olfactory evaluation of acylated products.

    PubMed

    Ramilijaona, Jade; Raynaud, Elsa; Bouhlel, Charfeddine; Sarrazin, Elise; Fernandez, Xavier; Antoniotti, Sylvain

    2013-12-01

    We have developed an enzymatic protocol to modify the composition of palmarosa essential oil by acylation of its alcohol components by three different acyl donors at various rates. The resulting modified products were characterized by qualitative and quantitative analyses by gas chromatography, and their olfactory properties were evaluated by professional perfumers. We showed that our protocol resulted in two types of modifications of the olfactory properties. The first and most obvious effect observed was the decrease of the alcohol content, with the concomitant increase of the corresponding esters, along with their fruity notes (pear, most notably). The second and less obvious effect was the expression of notes from minor components ((E)-β-ocimene, linalool, β-caryophyllene, and farnesene), originally masked by the sweet-floral-rose odor of geraniol, present in 70% in the palmarosa essential oil used, and emergence of citrus, green, spicy and clove characters in the modified products. This methodology might be considered in the future as a sustainable route to new natural ingredients for the perfumer.

  16. Modification of integrated partial payload lifting assembly

    NASA Technical Reports Server (NTRS)

    Groah, Melodie; Haddock, Michael; Woodworth, Warren

    1986-01-01

    The Integrated Partial Payload Lifting Assembly (IPPLA) is currently used to transport and load experimental payloads into the cargo bay of the Space Shuttle. It is unable to carry the astronaut/passenger tunnel without a structural modification. The purpose of this design is to create a removalbe modification that will allow the IPPLA to lift and carry the passenger tunnel. Modifications evaluated were full-length insert beams which would extend through the existing strongback arms. These beam proposals were eliminated because of high cost and weight. Other proposals evaluated were attachments of cantilever beams to the existing strongback areas. The cantilever proposals reduced cost and weight compared to the full-length modifications. A third method evaluated was to simply make modifications to one side of the IPPLA therefore reducing the materials of the cantilever proposals by 40 percent. The design of the modification selected was completed with two channel beams jointly welded to a centered steel plate. The extension arm modification is inserted into the existing strongback channel beams and bolted into place. Two extension arms are added to one side of the IPPLA to provide the extra length needed to accommodate the passenger tunnel. The center counterbalance will then be offset about 20 inches to center gravity and therefore maintain horizontal status. The extension arm modification was selected because of minimum cost, low weight, and minimal installation time.

  17. Proposed modifications to the RCRA post-closure permit for the Upper East Fork Poplar Creek Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Upper East Fork Poplar Creek Hydrogeologic Regime (permit number TNHW-088, EPA ID No. TN3 89 009 0001). The modifications are proposed to: (1) revise the current text for two of the Permit Conditions included in Permit Section II - General Facility Conditions, and (2) update the PCP with revised versions of the Y-12 Plant Groundwater Protection Program (GWPP) technical field procedures included in several of the Permit Attachments. The updated field procedures and editorial revisions are Class 1 permit modifications, as specified in Title 40, Code of Federal Regulations (CFR) {section}270.42; Appendix I - Classification of Permit Modifications. These modifications are summarized below.

  18. [The evaluation of oxidative modification of proteins in patients with chronic disseminated dermatosis].

    PubMed

    Kopitova, T V; Panteleyeva, G A; Dmitriyeva, O N; Kotkova, E V

    2014-02-01

    The analysis was made concerning oxidative modification of proteins of blood serum and erythrocytes in patients with chronic disseminated dermatosis. The high degree of total oxidative modification of proteins was established in patients with psoriasis and atopic dermatitis. The increase of level of oxidized derivatives of apoproteins in compound of lipoproteins of low density under psoriasis, atopic dermatitis and pemphigus was detected The increase of amount of carbonyl derivative of oligopeptids under psoriasis was revealed. In patients with resistance to applied therapy the statistically significant decrease of total oxidative modification of proteins of blood serum and erythrocytes was detected. This occurrence is possibly related to derangement of process of proteolytic destruction of proteins.

  19. 76 FR 69294 - Proposed Generic Communication Draft Generic Letter on Seismic Risk Evaluations for Operating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ... COMMISSION Proposed Generic Communication Draft Generic Letter on Seismic Risk Evaluations for Operating... public comment Draft Generic Letter 2011-XX: Seismic Risk Evaluations for Operating Reactors. The public... for public comment Draft Generic Letter 2011-XX: Seismic Risk Evaluations for Operating Reactors...

  20. 77 FR 18848 - Notice of Submission of Proposed Information Collection to OMB; Choice Neighborhoods Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... Evaluation, Phase I AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice. SUMMARY: The... grants and establishing a baseline for long-term evaluation of program outcomes. The information... lists the following information: Title of Proposal: Choice Neighborhoods Evaluation, Phase I....

  1. Proposed modification to avoidance test with Eisenia fetida to assess metal toxicity in agricultural soils affected by mining activities.

    PubMed

    Delgadillo, Víctor; Verdejo, José; Mondaca, Pedro; Verdugo, Gabriela; Gaete, Hernán; Hodson, Mark E; Neaman, Alexander

    2017-06-01

    Use of avoidance tests is a quick and cost-effective method of assessing contaminants in soils. One option for assessing earthworm avoidance behavior is a two-section test, which consists of earthworms being given the choice to move between a test soil and a control substrate. For ecological relevance, tested soils should be field-contaminated soils. For practical reasons, artificial soils are commonly used as the control substrate. Interpretation of the test results compromised when the test soil and the artificial substrate differ in their physico-chemical properties other than just contaminants. In this study we identified the physico-chemical properties that influence avoidance response and evaluated the usefulness of adjusting these in the control substrate in order to isolate metal-driven avoidance of field soils by earthworms. A standardized two-section avoidance test with Eisenia fetida was performed on 52 uncontaminated and contaminated (Cu >155mgkg(-1), As >19mgkg(-1)) agricultural soils from the Aconcagua River basin and the Puchuncaví Valley in Chile. Regression analysis indicated that the avoidance response was determined by soil organic matter (OM), electrical conductivity (EC) and total soil Cu. Organic matter content of the artificial substrate was altered by peat additions and EC by NaCl so that these properties matched those of the field soils. The resultant EC80 for avoidance (indicative of soils of "limited habitat") was 433mg Cu kg(-1) (339 - 528mgkg(-1) 95% confidence intervals). The earthworm avoidance test can be used to assess metal toxicity in field-contaminated soils by adjusting physico-chemical properties (OM and EC) of the artificial control substrate in order to mimic those of the field-collected soil.

  2. Attentional Bias Modification With Serious Game Elements: Evaluating the Shots Game

    PubMed Central

    Sanchez Maceiras, Soraya; Boffo, Marilisa; Wiers, Reinout W

    2016-01-01

    Background Young adults often experiment with heavy use of alcohol, which poses severe health risks and increases the chance of developing addiction problems. In clinical patients, cognitive retraining of automatic appetitive processes, such as selective attention toward alcohol (known as “cognitive bias modification of attention,” or CBM-A), has been shown to be a promising add-on to treatment, helping to prevent relapse. Objective To prevent escalation of regular use into problematic use in youth, motivation appears to play a pivotal role. As CBM-A is often viewed as long and boring, this paper presents this training with the addition of serious game elements as a novel approach aimed at enhancing motivation to train. Methods A total of 96 heavy drinking undergraduate students carried out a regular CBM-A training, a gamified version (called “Shots”), or a placebo training version over 4 training sessions. Measures of motivation to change their behavior, motivation to train, drinking behavior, and attentional bias for alcohol were included before and after training. Results Alcohol attentional bias was reduced after training only in the regular training condition. Self-reported drinking behavior was not affected, but motivation to train decreased in all conditions, suggesting that the motivational features of the Shots game were not enough to fully counteract the tiresome nature of the training. Moreover, some of the motivational aspects decreased slightly more in the game condition, which may indicate potential detrimental effects of disappointing gamification. Conclusions Gamification is not without its risks. When the motivational value of a training task with serious game elements is less than expected by the adolescent, effects detrimental to their motivation may occur. We therefore advise caution when using gamification, as well as underscore the importance of careful scientific evaluation. PMID:27923780

  3. Towards an automated tool to evaluate the impact of the nuclear modification of the gluon density on quarkonium, D and B meson production in proton-nucleus collisions

    NASA Astrophysics Data System (ADS)

    Lansberg, Jean-Philippe; Shao, Hua-Sheng

    2017-01-01

    We propose a simple and model-independent procedure to account for the impact of the nuclear modification of the gluon density as encoded in nuclear collinear PDF sets on two-to-two partonic hard processes in proton-nucleus collisions. This applies to a good approximation to quarkonium, D and B meson production, generically referred to H. Our procedure consists in parametrising the square of the parton scattering amplitude, A_{gg → HX} and constraining it from the proton-proton data. Doing so, we have been able to compute the corresponding nuclear modification factors for J/ψ , Υ and D^0 as a function of y and P_T at √{s_NN}=5 and 8 TeV in the kinematics of the various LHC experiments in a model independent way. It is of course justified since the most important ingredient in such evaluations is the probability of each kinematical configuration. Our computations for D mesons can also be extended to B meson production. To further illustrate the potentiality of the tool, we provide - for the first time - predictions for the nuclear modification factor for η _c production in pPb collisions at the LHC.

  4. 78 FR 26396 - Proposed Collection; Comments Requested: FBI National Academy Level 1 Evaluation: Student Course...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... Proposed Collection; Comments Requested: FBI National Academy Level 1 Evaluation: Student Course Questionnaire and FBI National Academy: General Remarks Questionnaire ACTION: 30-Day Notice. The Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Training Division's Curriculum Management...

  5. 78 FR 13085 - Proposed Collection, Comments Requested: FBI National Academy Level 1 Evaluation: Student Course...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... Federal Bureau of Investigation Proposed Collection, Comments Requested: FBI National Academy Level 1 Evaluation: Student Course Questionnaire and FBI National Academy: General Remarks Questionnaire ACTION: 60-day notice. The Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Training...

  6. 76 FR 9607 - Notice of Proposed Information Collection for Technical Evaluation Surveys

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... Office of Surface Mining Reclamation and Enforcement Notice of Proposed Information Collection for Technical Evaluation Surveys AGENCY: Office of Surface Mining Reclamation and Enforcement, Interior. ACTION... Office of Surface Mining Reclamation and Enforcement (OSM) is announcing that the information...

  7. 78 FR 11652 - Agency Information Collection Activities; Proposed Collection; Comment Request; Evaluation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Proposed Collection; Comment Request; Evaluation of the Program for Enhanced Review Transparency and Communication for... the Program for Enhanced Review Transparency and Communication (``the Program'') during fiscal...

  8. 75 FR 70949 - Proposed Information Collection for the Evaluation of the Aging Worker Initiative; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ... Employment and Training Administration Proposed Information Collection for the Evaluation of the Aging Worker Initiative; Comment Request AGENCY: Employment and Training Administration, Labor. ACTION: Notice. SUMMARY... burden conducts a preclearance consultation program to provide the general public and federal...

  9. 40 CFR 35.937-4 - Solicitation and evaluation of proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... relative importance attached to each criterion (a numerical weighted formula need not be utilized). (c) All... subpart. The grantee shall also evaluate the candidate's proposed method to accomplish the work...

  10. Economic evaluation: Concepts, selected studies, system costs, and a proposed program

    NASA Technical Reports Server (NTRS)

    Osterhoudt, F. H. (Principal Investigator)

    1979-01-01

    The more usual approaches to valuing crop information are reviewed and an integrated approach is recommended. Problems associated with implementation are examined. What has already been accomplished in the economic evaluation of LACIE-type information is reported including various studies of benefits. The costs of the existing and proposed systems are considered. A method and approach is proposed for further studies.

  11. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Evaluating proposals of foreign iron, steel... proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods...

  12. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Evaluating proposals of foreign iron, steel... proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods...

  13. A proposed framework for evaluation of support courses in a nursing curriculum.

    PubMed

    Smillie, C; Wong, J; Arklie, M

    1984-09-01

    Evaluation of nursing educational programmes has received increased attention since the early 1970s. Many evaluation models have been proposed; they are intended for evaluation of the total educational programme, but provide little evidence on the relevancy of the support courses to nursing practice. This paper describes one nursing school's experience in evaluation of a support course. The nature and sources of problems and difficulties encountered during the evaluation process are also discussed. The authors propose a framework for evaluation of support courses in a nursing curriculum. This framework is an application of the Glaser, Stufflebeam and Stake models of programme evaluation. It is designed to assist nurse educators to strive for sound curriculum decisions.

  14. Improving Evaluation in Nonprofit Organizations: A Study of How Evaluation Requests for Proposals Are Developed, Responded to, and Fulfilled

    ERIC Educational Resources Information Center

    Matthews, Nakia S.

    2015-01-01

    It is often necessary for nonprofit organizations (NPOs) to formulate a Request for Proposal (RFP) to procure essential contracted services. This is most common when seeking the services of an external evaluator. Since most NPOs do not have internal evaluation staff, developing an appropriate RFP can be quite challenging. With limited literature…

  15. Proposed Framework for Presenting Injury Data Using the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) Diagnosis Codes.

    PubMed

    Hedegaard, Holly; Johnson, Renee L; Warner, Margaret; Chen, Li-Hui; Annest, J Lee

    2016-01-22

    Frameworks based on the International Classification of Diseases (ICD) provide injury researchers and epidemiologists with standard approaches for presenting and analyzing injury-related mortality and morbidity data. Injury diagnosis frameworks, such as the Barell Matrix for the ICD Ninth Revision, Clinical Modification (ICD-9-CM) and the Injury Mortality Diagnosis Matrix for the ICD Tenth Revision (ICD-10), categorize ICD codes into major body region (e.g., head, chest, abdomen, or extremity) by nature-of-injury (e.g., fracture, laceration, organ injury, or vascular injury) categories. In the United States, morbidity coding transitioned from ICD-9- CM to ICD-10-CM on October 1, 2015. In preparation for the use of ICD-10-CMcoded morbidity data for injury surveillance and data analysis, the National Center for Health Statistics and the National Center for Injury Prevention and Control propose an ICD-10-CM Injury Diagnosis Matrix to provide a standard approach for categorizing injuries by body region and nature of injury. This report provides a brief description of the differences between ICD-9-CM and ICD-10-CM injury diagnosis codes, introduces the proposed framework and the methods used to create it, and provides a list of additional considerations for review and comment by researchers and subjectmatter experts in injury data and surveillance.

  16. Evaluation of the structural modifications induced by mitomycin C on nucleic acids.

    PubMed

    Jolles, B; Laigle, A; Liquier, J; Chinsky, L

    1993-04-01

    The interaction of poly(dG-dC).poly(dG-dC) with mitomycin C, an antitumor antibiotic, has been studied by various spectroscopic methods: circular dichroism, Fourier transform infrared resonance Raman scattering and using fluorescence emission of terbium bound to unpaired guanines as local conformation probe. The results allowed us to confirm the lack of long range modification of the DNA secondary structure upon binding. They also brought first information concerning the modification of the local structure of the nucleic acid at the level of mono- or bifunctional adducts.

  17. 45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Early termination of research support: Evaluation... Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.123 Early termination of research support: Evaluation of applications and proposals. (a) The department or agency head...

  18. 49 CFR 11.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Early termination of research support: Evaluation of applications and proposals. 11.123 Section 11.123 Transportation Office of the Secretary of Transportation PROTECTION OF HUMAN SUBJECTS § 11.123 Early termination of research support: Evaluation...

  19. 7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1c.123 Section 1c.123 Agriculture Office of the Secretary of Agriculture PROTECTION OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications...

  20. 28 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROTECTION OF HUMAN SUBJECTS § 46.123 Early termination of research support: Evaluation...

  1. 77 FR 66649 - Proposed Revision to Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... COMMISSION Proposed Revision to Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors...), Section 19.0 ``Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors.'' The NRC is... probabilistic risk assessment (PRA) information and severe accident assessments for new reactors submitted...

  2. 75 FR 382 - Proposed Collection; Comment Request; Process Evaluation of the NIH's Roadmap Interdisciplinary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ...; Comment Request; Process Evaluation of the NIH's Roadmap Interdisciplinary Research Work Group Initiatives... be submitted to the Office of Management and Budget (OMB) for review and approval. Proposed... requests a three-year clearance for the ``Process Evaluation of the NIH Roadmap Interdisciplinary...

  3. 78 FR 43205 - Proposed Substances To Be Evaluated for Set 27 Toxicological Profiles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... HUMAN SERVICES Agency for Toxic Substances and Disease Registry Proposed Substances To Be Evaluated for Set 27 Toxicological Profiles AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR... evaluated for Set 27 toxicological profiles. SUMMARY: The Agency for Toxic Substances and Disease...

  4. 75 FR 34146 - Proposed Collection; Comment Request Resource for the Collection and Evaluation of Human Tissues...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request Resource for the Collection and Evaluation of Human Tissues and Cells From Donors With an Epidemiology Profile (NCI) SUMMARY... Collection: Title: Resource for the Collection and Evaluation of Human Tissues and Cells From Donors With...

  5. 77 FR 69507 - Proposed Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... COMMISSION Proposed Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task... Designs'' AGENCY: Nuclear Regulatory Commission. ACTION: Notice of opportunity for public comment. SUMMARY... evaluation (SE) for plant- specific adoption of Technical Specifications (TS) Task Force (TSTF) Traveler...

  6. NASA RECON: Course development, administration, and evaluation. A research and development proposal

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Roquemore, Leroy

    1984-01-01

    This proposal addresses the development, administration, and evaluation of a set of transportable, college-level courses to educate science and engineering students in the effective use of automated scientific and technical information storage and retrieval systems, and, in particular, in the use of the NASA RECON system. Chapter 1 presents a brief introduction. Chapter 2 identifies general and specific objectives, i.e., needs analysis, course development, course administration, and course evaluation. Chapter 3 proposes the methodology to be used in successfully accomplishing these objectives. Chapter 4 highlights expected results and product deliverables, and Chapter 5 presents the project evaluation plan to be followed. Chapter 6 is a brief overview of the institutional resources available at the proposing institutions, i.e., at the University of Southwestern Louisiana and at Southern University to support the project. Chapter 7 proposes a budget, time schedule, and management plan. Chapter 8 is a summary of the foregoing.

  7. Evaluation of surface sensible heat flux effects on the generation and modification of mesoscale circulations

    NASA Technical Reports Server (NTRS)

    Segal, M.; Pielke, R. A.; Mahrer, Y.

    1984-01-01

    Mesoscale thermal-induced circulations generated by horizontal gradients in surface characteristics as well as significant perturbations on land and sea breezes and mountain-valley winds due to substantial modifications in the thermal forcing are introduced. It is suggested that these types of mesoscale situations are generally ignored in forecasting but that they may have important implications in very short range predictions.

  8. Evaluation of a Cooperative Extension Curriculum in Florida: Food Modification for Special Needs

    ERIC Educational Resources Information Center

    Dahl, Wendy J.; Ford, Amanda L.; Radford, Allyson; Gal, Nancy J.

    2016-01-01

    State and national surveys of adult family care homes identified a strong need for education on texture-modified food preparation and the nutritional needs of older adults. An Extension curriculum, Food Modification for Special Needs, was developed to provide an overview of chewing and swallowing problems, food texture, pureed food preparation,…

  9. Formative Evaluation of Project "TEAM" (Teens Making Environment and Activity Modifications)

    ERIC Educational Resources Information Center

    Kramer, Jessica M.; Roemer, Kristin; Liljenquist, Kendra; Shin, Julia; Hart, Stacy

    2014-01-01

    Research documents the negative impact of physical and social environmental barriers on engagement in school, work, and the community for youth with intellectual and /or developmental disabilities (IDD). Project "TEAM" (Teens making Environment and Activity Modifications) was designed to teach youth to systematically identify…

  10. Evaluation of heterogeneous metal-organic framework organocatalysts prepared by postsynthetic modification.

    PubMed

    Garibay, Sergio J; Wang, Zhenqiang; Cohen, Seth M

    2010-09-06

    A metal-organic framework (MOF) containing 2-amino-1,4-benzenedicarboxylate (NH(2)-BDC) as a building block is shown to undergo chemical modification with a set of cyclic anhydrides. The modification of the aluminum-based MOF known as MIL-53(Al)-NH(2) (MIL = Material Institut Lavoisier) by these reagents is demonstrated by using a variety of methods, including NMR and electrospray ionization mass spectrometry (ESI-MS), and the structural integrity of the modified MOFs has been confirmed by thermal gravimetric analysis (TGA) and powder X-ray diffraction (PXRD). Reaction with these cyclic anhydrides produces MOFs that display carboxylic acid functional groups within their pores. Furthermore, it is shown that maleic acid functionalized MIL-53(Al)-AMMal can act as a Brønsted acid catalyst and facilitate the methanolysis of several small epoxides. Experiments show that MIL-53(Al)-AMMal acts in a heterogeneous manner and is recyclable with consistent activity over at least three catalytic cycles. The findings presented here demonstrate several important features of covalent postsynthetic modification (PSM) on MOFs, including (1) facile introduction of catalytic functionality using simple organic reagents (e.g., anhydrides); (2) the ability to utilize and recycle organocatalytic MOFs; (3) control of catalytic activity through choice of functional group. The findings clearly illustrate that covalent postsynthetic modification represents a powerful means to access new MOF compounds that serve as organocatalytic materials.

  11. Evaluation of Heterogeneous Metal-Organic Framework Organocatalysts Prepared by Postsynthetic Modification

    PubMed Central

    Garibay, Sergio J.; Wang, Zhenqiang; Cohen, Seth M.

    2010-01-01

    A metal-organic framework (MOF) containing 2-amino-1,4-benzenedicarboxylate (NH2-BDC) as a building block is shown to undergo chemical modification with a set of cyclic anhydrides. The modification of the aluminum-based MOF known as MIL-53(Al)-NH2 (MIL = Matérial Institut Lavoisier) by these reagents is demonstrated by using a variety of methods, including NMR and ESI-MS, and the structural integrity of the modified MOFs has been confirmed by TGA, PXRD, and gas sorption analysis. Reaction with these cyclic anhydrides produces MOFs that display carboxylic acid functional groups within their pores. Furthermore, it is shown that maleic acid functionalized MIL-53(Al)-AMMal can act as a Brønsted acid catalyst and facilitate the methanolysis of several small epoxides. Experiments show that MIL-53(Al)-AMMal acts in a heterogeneous manner and is recyclable with consistent activity over at least three catalytic cycles. The findings presented here demonstrate several important features of covalent postsynthetic modification (PSM) on MOFs, including: 1) facile introduction of catalytic functionality using simple organic reagents (e.g. anhydrides); 2) the ability to utilize and recycle organocatalytic MOFs; 3) control of catalytic activity through choice of functional group. The findings clearly illustrate that covalent postsynthetic modification represents a powerful means to access new MOF compounds that serve as organocatalytic materials. PMID:20698561

  12. Evaluation in Cross-Cultural Contexts: Proposing a Framework for International Education and Training Project Evaluations.

    ERIC Educational Resources Information Center

    bin Yahya, Ismail; And Others

    This paper focuses on the need for increased sensitivity and responsiveness in international education and training project evaluations, particularly those in Third World countries. A conceptual-theoretical framework for designing and developing models appropriate for evaluating education and training projects in non-Western cultures is presented.…

  13. Calendar year 1994 groundwater quality report for the Bear Creek hydrogeologic regime, Y-12 Plant, Oak Ridge, Tennessee. 1994 Groundwater quality data interpretations and proposed program modifications

    SciTech Connect

    1995-10-01

    This groundwater quality report (GWQR) contains an evaluation of the groundwater quality data obtained during the 1994 calendar year (CY) at several hazardous and non-hazardous waste management facilities at the US Department of Energy (DOE) Y-12 Plant. These sites lie in Bear Creek Valley (BCV) west of the Y-12 Plant within the boundaries of the Bear Creek Hydrogeologic Regime which is one of three hydrogeologic regimes defined for the purposes of groundwater quality monitoring. The Environmental Management Department manages the groundwater monitoring activities under the auspices of the Y-12 Plant Groundwater Protection Program (GWPP). The purpose of the GWPP is to characterize the hydrogeology and to monitor groundwater quality at the Y-12 Plant and surrounding area to protect local groundwater resources. The annual GWQR for the Bear Creek Regime is completed in two parts. Part 1 consists primarily of data appendices and serves as a reference for the groundwater quality data obtained each CY. Part 2 (this report) contains an evaluation of the data with respect to regime-wide groundwater quality, summarizes the status and findings of ongoing hydrogeologic studies, describes changes in monitoring priorities, and presents planned modifications to the groundwater sampling and analysis activities.

  14. A prototype decision aid for evaluating and selecting R&D proposals

    SciTech Connect

    Al-Ayat, R.A.; Lamont, A.; Sicherman, A.

    1992-05-01

    This report describes a prototype decision aid which has been developed to assist the Institutional Research and Development (IR&D) Committee in selecting proposals for funding. This tool was requested to help address the following concerns about the IR&D proposal selection process: Some good proposals might be overlooked simply because no one on the Committee advocates them forcefully. The process takes a lot of time. The final portfolio of proposals selected may not maximize the long-run benefits to the Laboratory. These concerns stem from the observation that there is no formal framework for making distinctions between proposals, or weighing and comparing those distinctions. It was felt that the process could be improved by a framework that: Provides explicit descriptors that Committee members can use to evaluate and compare different features of proposals. Encourages the Committee to use a uniform, systematic scheme for evaluating the proposals. Helps the Committee focus more quickly on the issues that are truly relevant for distinguishing between proposals.

  15. Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity

    PubMed Central

    Subba Rao, G. S. R.; Kondaiah, Paturu; Singh, Sanjay K.; Ravanan, Palaniyandi; Sporn, Michael B.

    2008-01-01

    Synthetic analogues of naturally occurring triterpenoids; glycyrrhetinic acid, arjunolic acid and boswellic acids, by modification of A-ring with a cyano- and enone- functionalities, have been reported. A novel method of synthesis of α-cyanoenones from isoxazoles is reported. Bio-assays using primary mouse macrophages and tumor cell lines indicate potent anti-inflammatory and cytotoxic activities associated with cyanoenones of boswellic acid and glycyrrhetinic acid. PMID:20622928

  16. Evaluation of surface modification techniques for PWR steam generator channel heads. Final report

    SciTech Connect

    Spalaris, C.N.

    1986-06-01

    Surface modification which were developed under a previous EPRI program and then applied to Boiling Water Reactor replacement piping, were modified for treating PWR steam generator channel head surfaces. Surface modifications have been shown to reduce out-of-core activity build up in BWR and thought to be equally effective in PWR circuits as well. Prototypical surface test specimens were used to develop techniques appropriate to PWR alloy substrates which were then applied to treat the surfaces of a spare, full size PWR channel head in a field demonstration. Modified surfaces cut from test specimens and pieces removed from the field demonstration were submitted to metallurgical investigations. No damage to the substrate alloys was detected as a result of the surface modification processes. Combination of mechanical and electropolishing action improved the as fabricated finish by at least a factor of 3 for the Inconel plate and factors of 20 for the stainless weld overlay. Field demonstration yielded a factor of 10 improvement in the weld overlay and 30 to 40% in the divider plate. Because these surfaces are known to be responsible for 57% of the area radioactivity in PWR steam generators in service, prepolishing is expected to reduce radiation fields substantially. 31 figs.

  17. Evaluation of protein modification during anti-viral heat bioprocessing by electrospray ionization mass spectrometry.

    PubMed

    Smales, C M; Pepper, D S; James, D C

    2001-01-01

    During the preparation of therapeutic plasma and recombinant protein biopharmaceuticals heat-treatment is routinely applied as a means of viral inactivation. However, as most proteins denature and aggregate under heat stress, it is necessary to add thermostabilizing excipients to protein formulations destined for anti-viral heat-treatment in order to prevent protein damage. Anti-viral heat-treatment bioprocessing therefore requires that a balance be found between the bioprocessing conditions, virus kill and protein integrity. In this study we have utilized a simple model protein, beta-lactoglobulin, to investigate the relationship between virucidal heat-treatment conditions (protein formulation and temperature) and the type and extent of protein modification in the liquid state. A variety of industrially relevant heat-treatments were undertaken, using formulations that included sucrose as a thermostabilizing excipient. Using liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) we show here that protein modifications do occur with increasingly harsh heat-treatment. The predominant modification under these conditions was protein glycation by either glucose or fructose derived from hydrolyzed sucrose. Advanced glycation end products and additional unidentified products were also present in beta-lactoglobulin protein samples subjected to extended heat-treatment. These findings have implications for the improvement of anti-viral heat-treatment bioprocesses to ensure the safety and efficacy of protein biopharmaceuticals. CopyrightCopyright 2001 John Wiley & Sons, Ltd.

  18. Calendar year 1993 groundwater quality report for the Chestnut Ridge Hydrogeologic Regime Y-12 Plant, Oak Ridge, Tennessee. 1993 Groundwater quality data interpretations and proposed program modifications

    SciTech Connect

    1994-09-01

    This groundwater quality report (GWQR) contains an evaluation of the groundwater quality data obtained during the 1993 calendar year (CY) at several hazardous and non-hazardous waste management facilities associated with the US DOE Y-12 Plant located on the DOE Oak Ridge Reservation (ORR) southeast of Oak Ridge, Tennessee. The groundwater quality data are presented in Part 1 of the GWQR submitted by Martin Marietta Energy Systems, Inc. to the Tennessee Department of Environment and Conservation (TDEC) in February 1994. Groundwater quality data evaluated in this report were obtained at several hazardous and non-hazardous waste management sites located within the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime). The Chestnut Ridge Regime encompasses a section of Chestnut Ridge south of the Y-12 Plant and is one of three hydrogeologic regimes defined for the purposes of groundwater quality monitoring at the plant. The Environmental Management Department of the Y-12 Plant Health, Safety, Environment, and Accountability Organization manages the groundwater monitoring activities in each regime as part of the Y-12 Plant Groundwater Protection Program (GWPP). The annual GWQR for the Chestnut Ridge Regime is completed in two parts. Part 1 consists primarily of data appendices and serves as a reference for the groundwater quality data obtained each CY under the lead of the Y-12 Plant GWPP. Because it contains information needed to comply with Resource Conservation and Recovery Act (RCRA) interim status assessment monitoring and reporting requirements, the Part 1 GWQR is submitted to the TDEC by the RCRA reporting deadline (March 1 of the following CY). Part 2 (this report) contains an evaluation of the data with respect to regime-wide groundwater quality, presents the findings and status of ongoing hydrogeologic studies, describes changes in monitoring priorities, and presents planned modifications to the groundwater sampling and analysis activities.

  19. Managing proposals and evaluations of updates to medical knowledge: theory and applications.

    PubMed

    Anselma, Luca; Bottrighi, Alessio; Montani, Stefania; Terenziani, Paolo

    2013-04-01

    The process of keeping up-to-date the medical knowledge stored in relational databases is of paramount importance. Since quality and reliability of medical knowledge are essential, in many cases physicians' proposals of updates must undergo experts' evaluation before possibly becoming effective. However, until now no theoretical framework has been provided in order to cope with this phenomenon in a principled and non-ad hoc way. Indeed, such a framework is important not only in the medical domain, but in all Wikipedia-like contexts in which evaluation of update proposals is required. In this paper we propose GPVM (General Proposal Vetting Model), a general model to cope with update proposal⧹evaluation in relational databases. GPVM extends the current theory of temporal relational databases and, in particular, BCDM - Bitemporal Conceptual Data Model - "consensus" model, providing a new data model, new operations to propose and accept⧹reject updates, and new algebraic operators to query proposals. The properties of GPVM are also studied. In particular, GPVM is a consistent extension of BCDM and it is reducible to it. These properties ensure consistency with most relational temporal database frameworks, facilitating implementation on top of current frameworks and interoperability with previous approaches.

  20. Evaluation of dredged material proposed for ocean disposal from Buttermilk Channel, New York

    SciTech Connect

    Gardiner, W.W.; Barrows, E.S.; Antrim, L.D; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-08-01

    Buttermilk Channel was one of seven waterways that was sampled and evaluated for dredging and sediment disposal. Sediment samples were collected and analyses were conducted on sediment core samples. The evaluation of proposed dredged material from the channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples were analyzed for grain size, moisture content, and total organic carbon. A composite sediment samples, representing the entire area proposed for dredging, was analyzed for bulk density, polynuclear aromatic hydrocarbons, and 1,4-dichlorobenzene. Site water and elutriate were analyzed for metals, pesticides, and PCBs.

  1. Proposal and Evaluation of Management Method for College Mechatronics Education Applying the Project Management

    NASA Astrophysics Data System (ADS)

    Ando, Yoshinobu; Eguchi, Yuya; Mizukawa, Makoto

    In this research, we proposed and evaluated a management method of college mechatronics education. We applied the project management to college mechatronics education. We practiced our management method to the seminar “Microcomputer Seminar” for 3rd grade students who belong to Department of Electrical Engineering, Shibaura Institute of Technology. We succeeded in management of Microcomputer Seminar in 2006. We obtained the good evaluation for our management method by means of questionnaire.

  2. Modification and Adaptation of the Program Evaluation Standards in Saudi Arabia

    ERIC Educational Resources Information Center

    Alyami, Mohammed

    2013-01-01

    The Joint Committee on Standards for Educational Evaluation's Program Evaluation Standards is probably the most recognized and applied set of evaluation standards globally. The most recent edition of The Program Evaluation Standards includes five categories and 30 standards. The five categories are Utility, Feasibility, Propriety, Accuracy, and…

  3. Numerical performance evaluation of design modifications on a centrifugal pump impeller running in reverse mode

    NASA Astrophysics Data System (ADS)

    Kassanos, Ioannis; Chrysovergis, Marios; Anagnostopoulos, John; Papantonis, Dimitris; Charalampopoulos, George

    2016-06-01

    In this paper the effect of impeller design variations on the performance of a centrifugal pump running as turbine is presented. Numerical simulations were performed after introducing various modifications in the design for various operating conditions. Specifically, the effects of the inlet edge shape, the meridional channel width, the number of blades and the addition of splitter blades on impeller performance was investigated. The results showed that, an increase in efficiency can be achieved by increasing the number of blades and by introducing splitter blades.

  4. Viscosity-Modification to Improve Remediation Efficiencies within Heterogeneous Contaminated Groundwater Aquifers: Laboratory and Field-Scale Evaluation

    NASA Astrophysics Data System (ADS)

    Silva, J. A.; Crimi, M.

    2013-12-01

    A key challenge in in situ groundwater remediation practice is achieving efficient contact between the injected remedial fluid and the target contamination in the presence of subsurface permeability heterogeneities. Even apparently small permeability contrasts can affect the delivery and subsurface distribution of injected remedial fluids, as a result of preferential flows, and reduce treatment effectiveness as a result of bypassing of contaminated media of lower permeability. Viscosity-modification is a technique that can be used to mitigate the effects of permeability heterogeneity and improve the delivery and distribution of remediation fluids during subsurface injection. Viscosity-modification involves increasing the viscosity of the injected fluid, and modifying the fluids rheological character in some cases. The increased viscosity provides a reduced fluid mobility condition within higher permeability media that, in turn, enhances the penetration of fluids into adjacent lower permeability media, improving the overall sweep efficiency within heterogeneous geomedia. Herein, we present the results of laboratory (two-dimensional flow tank) and numerical experiments that were designed to critically evaluate the utility of viscosity-modification for groundwater remediation application. Specifically, we will address the benefits and limitations of the approach and highlight the effect of system variables on the degree sweep efficiency improvement achievable. We also present the results of a recently completed Environmental Security Technology Certification Program (ESTCP) technology validation project in which viscosity-modification was applied to permanganate in situ chemical oxidation. Site selection criteria, implementation design considerations, and the long-term effects of viscosity-modified fluid treatments will be discussed.

  5. Assessment of home-based behavior modification programs for autistic children: reliability and validity of the behavioral summarized evaluation.

    PubMed

    Oneal, Brent J; Reeb, Roger N; Korte, John R; Butter, Eliot J

    2006-01-01

    Since the publication of Lovaas' (1987) impressive findings, there has been a proliferation of home-based behavior modification programs for autistic children. Parents and other paraprofessionals often play key roles in the implementation and monitoring of these programs. The Behavioral Summarized Evaluation (BSE) was developed for professionals and paraprofessionals to use in assessing the severity of autistic symptoms over the course of treatment. This paper examined the psychometric properties of the BSE (inter-item consistency, factorial composition, convergent validity, and sensitivity to parents' perceptions of symptom change over time) when used by parents of autistic youngsters undergoing home-based intervention. Recommendations for future research are presented.

  6. 77 FR 36292 - Proposed Collection, Comments Requested: FBI National Academy Level III Evaluation; FBI National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ... Federal Bureau of Investigation Proposed Collection, Comments Requested: FBI National Academy Level III Evaluation; FBI National Academy Post-Course Questionnaire for Graduates, FBI National Academy Post-Course... Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Training Division's Office of...

  7. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  8. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  9. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  10. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  11. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... rights and welfare of human subjects (whether or not the research was subject to federal regulation). ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare DEPARTMENT OF HEALTH AND...

  12. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... rights and welfare of human subjects (whether or not the research was subject to federal regulation). ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare DEPARTMENT OF HEALTH AND...

  13. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... rights and welfare of human subjects (whether or not the research was subject to federal regulation). ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare DEPARTMENT OF HEALTH AND...

  14. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... rights and welfare of human subjects (whether or not the research was subject to federal regulation). ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare Department of Health and...

  15. 15 CFR 27.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 27.123 Section 27.123 Commerce and Foreign Trade Office of the Secretary of Commerce PROTECTION OF HUMAN SUBJECTS § 27.123 Early termination of research...

  16. 16 CFR 1028.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1028.123 Section 1028.123 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL PROTECTION OF HUMAN SUBJECTS § 1028.123 Early termination of research...

  17. 76 FR 31683 - Proposed Information Collection (NCA PreNeed Burial Evaluation) Activity: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... AFFAIRS Proposed Information Collection (NCA PreNeed Burial Evaluation) Activity: Comment Request AGENCY... techniques or the use of other forms of information technology. Title: NCA PreNeed Burial Eligibility... to determine their eligibility for burial in a National Cemetery prior to the actual time of...

  18. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Early termination of research support: Evaluation of applications and proposals. 97.123 Section 97.123 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy...

  19. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Early termination of research support: Evaluation of applications and proposals. 97.123 Section 97.123 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy...

  20. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 97.123 Section 97.123 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy...

  1. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Early termination of research support: Evaluation of applications and proposals. 97.123 Section 97.123 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy...

  2. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Early termination of research support: Evaluation of applications and proposals. 97.123 Section 97.123 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy...

  3. 48 CFR 2052.215-79 - Contract award and evaluation of proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... REGULATORY COMMISSION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 2052.215-79 Contract award and evaluation of proposals. As prescribed in 2015.209(a)(1), the... specified in paragraph * below. These factors are listed in their relative order of importance. (b)...

  4. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Evaluating proposals of foreign iron, steel... iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods being unreasonable,...

  5. Evaluating a Proposed Learning Experience in Terms of Eight Learning Theories.

    ERIC Educational Resources Information Center

    Abram, Marie J.

    The work of eight learning theorists was used to evaluate a proposed adult education/learning experience in an effort to operationalize a system for locating strengths and weaknesses in an instructional system prior to its implementation. Thirty-five implications for adult education were extrapolated from work representing the Behaviorist (B.F.…

  6. 75 FR 68317 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... examined with relatively simple measures of food choices, nutritional behaviors and Body Mass Index (BMI... Food and Nutrition Service Agency Information Collection Activities: Proposed Collection; Comment Request--Evaluation of the Summer Electronic Benefits for Children Household-Based Demonstrations on...

  7. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  8. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  9. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  10. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  11. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  12. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS... directed the scientific and technical aspects of an activity has have, in the judgment of the department...

  13. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS... directed the scientific and technical aspects of an activity has have, in the judgment of the department...

  14. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS... directed the scientific and technical aspects of an activity has have, in the judgment of the department...

  15. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS... directed the scientific and technical aspects of an activity has have, in the judgment of the department...

  16. 77 FR 75251 - 60-Day Notice of Proposed Information Collection: Gilman Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... Notice of Proposed Information Collection: Gilman Evaluation Survey ACTION: Notice of request for public... the information collection described below. In accordance with the Paperwork Reduction Act of 1995, we...), information collection title, and the OMB control number in any correspondence. FOR FURTHER...

  17. 77 FR 66951 - Proposed Information Collection; Comment Request; BIS Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ... Bureau of Industry and Security Proposed Information Collection; Comment Request; BIS Program Evaluation... information collections, as required by the Paperwork Reduction Act of 1995. DATES: Written comments must be...., Washington, DC 20230 (or via the Internet at JJessup@doc.gov ). FOR FURTHER INFORMATION CONTACT: Requests...

  18. Biomechanical Evaluation of Flexor Tendon Graft With Different Repair Techniques and Graft Surface Modification

    PubMed Central

    Wu, Jingheng; Thoreson, Andrew R.; Reisdorf, Ramona L.; An, Kai-Nan; Moran, Steven L.; Amadio, Peter C.; Zhao, Chunfeng

    2016-01-01

    The purpose of this study was to investigate the biomechanical properties of modified repair techniques for flexor tendon reconstruction and the effects of surface modification using carbodiimide-derivatized synovial fluid plus gelatin (cd-SF-G), compared to the traditional repair techniques. The second and fifth digits from 16 canine forepaws were randomly divided into 4 groups: (1) traditional graft repairs (TGR group) including distal Bunnell repair and proximal Pulvertaft weave repair; (2) modified graft repairs (MGR group) including distal graft bony attachment repair and proximal step-cut repair; (3) group TGR coated with cd-SF-G (TGR-C group); and (4) group MGR coated with cd-SF-G (MGR-C group). Digit normalized work of flexion (nWOF), ultimate failure strength, and stiffness were measured. The nWOF in MGR group was significantly less than TGR group (p < 0.05). The nWOF in groups treated with cd-SF-G was significantly less than their untreated counterparts (p < 0.05). Ultimate load to failure of the MGR-C group was significantly greater than the TGR-C group (p < 0.05), but no significant difference in stiffness was found between these two groups. The modified techniques cannot only improve tendon gliding abilities but can also improve breaking strength. Additionally, surface modification with cd-SF-G significantly decreased the work of flexion. PMID:25665071

  19. Proposed Framework for the Evaluation of Standalone Corpora Processing Systems: An Application to Arabic Corpora

    PubMed Central

    Al-Thubaity, Abdulmohsen; Alqifari, Reem

    2014-01-01

    Despite the accessibility of numerous online corpora, students and researchers engaged in the fields of Natural Language Processing (NLP), corpus linguistics, and language learning and teaching may encounter situations in which they need to develop their own corpora. Several commercial and free standalone corpora processing systems are available to process such corpora. In this study, we first propose a framework for the evaluation of standalone corpora processing systems and then use it to evaluate seven freely available systems. The proposed framework considers the usability, functionality, and performance of the evaluated systems while taking into consideration their suitability for Arabic corpora. While the results show that most of the evaluated systems exhibited comparable usability scores, the scores for functionality and performance were substantially different with respect to support for the Arabic language and N-grams profile generation. The results of our evaluation will help potential users of the evaluated systems to choose the system that best meets their needs. More importantly, the results will help the developers of the evaluated systems to enhance their systems and developers of new corpora processing systems by providing them with a reference framework. PMID:25610910

  20. Using a fuzzy comprehensive evaluation method to determine product usability: A proposed theoretical framework

    PubMed Central

    Zhou, Ronggang; Chan, Alan H. S.

    2016-01-01

    BACKGROUND: In order to compare existing usability data to ideal goals or to that for other products, usability practitioners have tried to develop a framework for deriving an integrated metric. However, most current usability methods with this aim rely heavily on human judgment about the various attributes of a product, but often fail to take into account of the inherent uncertainties in these judgments in the evaluation process. OBJECTIVE: This paper presents a universal method of usability evaluation by combining the analytic hierarchical process (AHP) and the fuzzy evaluation method. By integrating multiple sources of uncertain information during product usability evaluation, the method proposed here aims to derive an index that is structured hierarchically in terms of the three usability components of effectiveness, efficiency, and user satisfaction of a product. METHODS: With consideration of the theoretical basis of fuzzy evaluation, a two-layer comprehensive evaluation index was first constructed. After the membership functions were determined by an expert panel, the evaluation appraisals were computed by using the fuzzy comprehensive evaluation technique model to characterize fuzzy human judgments. Then with the use of AHP, the weights of usability components were elicited from these experts. RESULTS AND CONCLUSIONS: Compared to traditional usability evaluation methods, the major strength of the fuzzy method is that it captures the fuzziness and uncertainties in human judgments and provides an integrated framework that combines the vague judgments from multiple stages of a product evaluation process. PMID:28035943

  1. Design requirements for SRB production control system. Volume 3: Package evaluation, modification and hardware

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The software package evaluation was designed to analyze commercially available, field-proven, production control or manufacturing resource planning management technology and software package. The analysis was conducted by comparing SRB production control software requirements and conceptual system design to software package capabilities. The methodology of evaluation and the findings at each stage of evaluation are described. Topics covered include: vendor listing; request for information (RFI) document; RFI response rate and quality; RFI evaluation process; and capabilities versus requirements.

  2. [Proposal of a model for the evaluation of public oral health care for children].

    PubMed

    Martins, Luiz Gustavo Teixeira; de Lacerda, Josimari Telino; Nickel, Daniela Alba; Traebert, Jefferson

    2016-03-01

    This article proposes a model for quality evaluation of oral health care in children. The conceptual framework for the evaluation matrix consisted of evaluation studies on oral health care services in Brazil and other countries and a survey and review of prevailing public policies for children's health in Brazil. Two dimensions, Management and Provision, were evaluated in the quality of municipal management of pediatric oral health care. Management included two component dimensions, articulation and resources, while Provision included two more, "promotion and prevention" and "diagnosis and treatment". The evaluation matrix consisted of nine indicators in the Management dimension and nine in the Provision dimension. The indicators were elaborated in workshops with specialists. The model proved appropriate for application in municipalities with different population sizes and allows identifying the areas where managers should improve their actions.

  3. Proposed Amendment to Presidential Permit PP-63 and Associated Modifications to 500-kV International Transmission Line: Forbes, Minnesota to Manitoba, Canada, Northern States Power Company. Addendum to the final Environmental Assessment

    SciTech Connect

    Not Available

    1992-10-01

    This Addendum to the Final Environmental Assessment for the Proposed Amendment to Presidential Permit PP-63 and Associated Modifications to 500 kV International Transmission Line: Forbes, Minnesota to Manitoba, Canada (DOE/EA-587) addresses Northern States Power Company`s (NSP) proposed expansion of the Forbes Substation. The applicant has requested that the expansion take place on the west side of the substation, within the existing property line, instead of on the north side as originally proposed. All of the proposed construction would take place on property already owned by NSP. DOE has reviewed the environmental impacts associated with this minor modification and has determined that the conclusions reached in the environmental assessment and Finding of No Significant Impact prepared in connection with NSP`s original amendment request remain valid.

  4. Comparative Proteomics for the Evaluation of Protein Expression and Modifications in Neurodegenerative Diseases.

    PubMed

    Conti, Antonio; Alessio, Massimo

    2015-01-01

    Together with hypothesis-driven approaches, high-throughput differential proteomic analysis performed primarily not only in human cerebrospinal fluid and serum but also on protein content of other tissues (blood cells, muscles, peripheral nerves, etc.) has been used in the last years to investigate neurodegenerative diseases. Even if the goal for these analyses was mainly the discovery of neurodegenerative disorders biomarkers, the characterization of specific posttranslational modifications (PTMs) and the differential protein expression resulted in being very informative to better define the pathological mechanisms. In this chapter are presented and discussed the positive aspects and challenges of the outcomes of some of our investigations on neurological and neurodegenerative disease, in order to highlight the important role of protein PTMs studies in proteomics-based approaches.

  5. Modifications to CTVS TV cameras for space shuttle compatibility and evaluation

    NASA Technical Reports Server (NTRS)

    Hoagland, K.

    1981-01-01

    Five all solid state cockpit television system (CTVS) cameras, built to USAF requirements for high performance type F-16 aircraft, were modified and tested for possible use in the closed circuit television system on the space shuttle orbiter. The 400 HZ power supply in the electronics unit assembly was replaced with two DC/DC converters to enable operation from 28VDC spacecraft-type power sources. Nonessential circuit functions were deleted to minimize input power requirements. The normal 31 mm focal length lense assemblies were replaced with wider field-of-view 19 mm focal length lenses. Base plates for and housings were redesigned to facilitate mounting and heat-sinking of the camera in the space environment and short length (14") adapter cables were designed, fabricated, and tested to meet requirements for cameras configured to mount on the astronauts helmet/visor assembly. Technical requirements, design implementation, environmental tests, Modifications prodedures, and reliability/quality efforts are discussed. Schematics are included.

  6. Evaluation of a proposed expert system development methodology: Two case studies

    NASA Technical Reports Server (NTRS)

    Gilstrap, Lewey

    1990-01-01

    Two expert system development projects were studied to evaluate a proposed Expert Systems Development Methodology (ESDM). The ESDM was developed to provide guidance to managers and technical personnel and serve as a standard in the development of expert systems. It was agreed that the proposed ESDM must be evaluated before it could be adopted; therefore a study was planned for its evaluation. This detailed study is now underway. Before the study began, however, two ongoing projects were selected for a retrospective evaluation. They were the Ranging Equipment Diagnostic Expert System (REDEX) and the Backup Control Mode Analysis and Utility System (BCAUS). Both projects were approximately 1 year into development. Interviews of project personnel were conducted, and the resulting data was used to prepare the retrospective evaluation. Decision models of the two projects were constructed and used to evaluate the completeness and accuracy of key provisions of ESDM. A major conclusion reached from these case studies is that suitability and risk analysis should be required for all AI projects, large and small. Further, the objectives of each stage of development during a project should be selected to reduce the next largest area of risk or uncertainty on the project.

  7. The Fear of Positive Evaluation Scale: assessing a proposed cognitive component of social anxiety.

    PubMed

    Weeks, Justin W; Heimberg, Richard G; Rodebaugh, Thomas L

    2008-01-01

    Cognitive-behavioral models propose that fear of negative evaluation is the core feature of social anxiety disorder. However, it may be that fear of evaluation in general is important in social anxiety, including fears of positive as well as negative evaluation. To test this hypothesis, we developed the Fear of Positive Evaluation Scale (FPES) and conducted analyses to examine the psychometric properties of the FPES, as well as test hypotheses regarding the construct of fear of positive evaluation (FPE). Responses from a large (n = 1711) undergraduate sample were utilized. The reliability, construct validity, and factorial validity of the FPES were examined; the distinction of FPE from fear of negative evaluation was evaluated utilizing confirmatory factor analysis; and the ability of FPE to predict social interaction anxiety above and beyond fear of negative evaluation was assessed. Results provide preliminary support for the psychometric properties of the FPES and the validity of the construct of FPE. The implications of FPE with respect to the study and treatment of social anxiety disorder are discussed.

  8. 38 CFR 16.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... disposition of applications and proposals for research to be conducted or supported by a Federal Department or... PROTECTION OF HUMAN SUBJECTS § 16.120 Evaluation and disposition of applications and proposals for research... will evaluate all applications and proposals involving human subjects submitted to the department...

  9. CCRS proposal for evaluating LANDSAT-D MSS and TM data

    NASA Technical Reports Server (NTRS)

    Strome, W. M.; Cihlar, J.; Goodenough, D. G.; Guertin, F. E. (Principal Investigator); Collins, A. B.

    1983-01-01

    Accomplishments in the evaluation of LANDSAT 4 data are reported. The objectives of the Canadian proposal are: (1) to quantify the LANDSAT-4 sensors and system performance for the purpose of updating the radiometric and geometric correction algorithms for MSS and for developing and evaluating new correction algorithms to be used for TM data processing; (2) to compare and access the degree to which LANDSAT-4 MSS data can be integrated with MSS imagery acquired from earlier LANDSAT missions; and (3) to apply image analysis and information extraction techniques for specific user applications such as forestry or agriculture.

  10. Model experiments to evaluate vortex dissipation devices proposed for installation on or near aircraft runways

    NASA Technical Reports Server (NTRS)

    Kohl, R. E.

    1973-01-01

    The effectiveness of various vortex dissipation devices proposed for installation on or near aircraft runways is evaluated on basis of results of experiments conducted with a 0.03-scale model of a Boeing 747 transport aircraft in conjunction with a simulated runway. The test variables included type of vortex dissipation device, mode of operation of the powered devices, and altitude, lift coefficient and speed of the generating aircraft. A total of fifteen devices was investigated. The evaluation is based on time sequence photographs taken in the vertical and horizontal planes during each run.

  11. Evaluation of dredged material proposed for ocean disposal from Shark River Project area

    SciTech Connect

    Antrim, L.D.; Gardiner, W.W.; Barrows, E.S.; Borde, A.B.

    1996-09-01

    The objective of the Shark River Project was to evaluate proposed dredged material to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Tests and analyses were conducted on the Shark River sediments. The evaluation of proposed dredged material consisted of bulk sediment chemical and physical analysis, chemical analyses of dredging site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation tests. Individual sediment core samples collected from the Shark River were analyzed for grain size, moisture content, and total organic carbon (TOC). One sediment composite was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4- dichlorobenzene. Dredging site water and elutriate, prepared from suspended-particulate phase (SPP) of the Shark River sediment composite, were analyzed for metals, pesticides, and PCBs. Benthic acute toxicity tests and bioaccumulation tests were performed.

  12. Final technical evaluation report for the proposed revised reclamation plan for the Atlas Corporation Moab Mill

    SciTech Connect

    1997-03-01

    This final Technical Evaluation Report (TER) summarizes the US Nuclear Regulatory Commission staff`s review of Atlas Corporation`s proposed reclamation plan for its uranium mill tailings pile near Moab, Utah. The proposed reclamation would allow Atlas to (1) reclaim the tailings pile for permanent disposal and long-term custodial care by a government agency in its current location on the Moab site, (2) prepare the site for closure, and (3) relinquish responsibility of the site after having its NRC license terminated. The NRC staff concludes that, subject to license conditions identified in the TER, the proposed reclamation plan meets the requirements identified in NRC regulations, which appear primarily in 10 CFR Part 40. 112 refs., 6 figs., 16 tabs.

  13. Evaluation of models proposed for the 1991 revision of the International Geomagnetic Reference Field

    USGS Publications Warehouse

    Peddie, N.W.

    1992-01-01

    The 1991 revision of the International Geomagnetic Reference Field (IGRF) comprises a definitive main-field model for 1985.0, a main-field model for 1990.0, and a forecast secular-variation model for the period 1990-1995. The five 1985.0 main-field models and five 1990.0 main-field models that were proposed have been evaluated by comparing them with one another, with magnetic observatory data, and with Project MAGNET aerial survey data. The comparisons indicate that the main-field models proposed by IZMIRAN, and the secular-variation model proposed jointly by the British Geological Survey and the US Naval Oceanographic Office, should be assigned relatively lower weight in the derivation of the new IGRF models. -Author

  14. A pilot study evaluating a one-session attention modification training to decrease overeating in obese children.

    PubMed

    Boutelle, Kerri N; Kuckertz, Jennie M; Carlson, Jordan; Amir, Nader

    2014-05-01

    There are a number of neurocognitive and behavioral mechanisms that contribute to overeating and obesity, including an attentional bias to food cues. Attention modification programs, which implicitly train attention away from specific cues, have been used in anxiety and substance abuse, and could logically be applied to food cues. The purpose of this study was to evaluate the initial efficacy of a single session attention modification training for food cues (AMP) on overeating in overweight and obese children. Twenty-four obese children who eat in the absence of hunger participated in two visits and were assigned to an attention modification program (AMP) or attentional control program (ACC). The AMP program trained attention away 100% of the time from food words to neutral words. The ACC program trained attention 50% of the time to neutral and 50% of the time to food. Outcome measures included the eating in the absence of hunger free access session, and measures of craving, liking and salivation. Results revealed significant treatment effects for EAH percent and EAH kcal (group by time interactions p<.05). Children in the ACC condition showed a significant increase over time in the number of calories consumed in the free access session (within group t=3.09, p=.009) as well as the percent of daily caloric needs consumed in free access (within group t=3.37, p=.006), whereas children in the AMP group demonstrated slight decreases in these variables (within group t=-0.75 and -0.63, respectively). There was a trend suggesting a beneficial effect of AMP as compared to ACC for attentional bias (group by time interaction p=.073). Changes in craving, liking and saliva were not significantly different between groups (ps=.178-.527). This is the first study to demonstrate that an AMP program can influence eating in obese children. Larger studies are needed to replicate and extend these results.

  15. Evaluation of AUSDRISK as a screening tool for lifestyle modification programs: international implications for policy and cost-effectiveness

    PubMed Central

    Malo, Jonathan A; Versace, Vincent L; Janus, Edward D; Laatikainen, Tiina; Peltonen, Markku; Vartiainen, Erkki; Coates, Michael J; Dunbar, James A

    2015-01-01

    Objective To evaluate the current use of Australian Type 2 Diabetes Risk Assessment Tool (AUSDRISK) as a screening tool to identify individuals at high risk of developing type 2 diabetes for entry into lifestyle modification programs. Research Design and Methods AUSDRISK scores were calculated from participants aged 40–74 years in the Greater Green Triangle Risk Factor Study, a cross-sectional population survey in 3 regions of Southwest Victoria, Australia, 2004–2006. Biomedical profiles of AUSDRISK risk categories were determined along with estimates of the Victorian population included at various cut-off scores. Sensitivity, specificity, positive predictive value (PPV), negative predictive value, and receiver operating characteristics were calculated for AUSDRISK in determining fasting plasma glucose (FPG) ≥6.1 mmol/L. Results Increasing AUSDRISK scores were associated with an increase in weight, body mass index, FPG, and metabolic syndrome. Increasing the minimum cut-off score also increased the proportion of individuals who were obese and centrally obese, had impaired fasting glucose (IFG) and metabolic syndrome. An AUSDRISK score of ≥12 was estimated to include 39.5% of the Victorian population aged 40–74 (916 000), while a score of ≥20 would include only 5.2% of the same population (120 000). At AUSDRISK≥20, the PPV for detecting FPG≥6.1 mmol/L was 28.4%. Conclusions AUSDRISK is powered to predict those with IFG and undiagnosed type 2 diabetes, but its effectiveness as the sole determinant for entry into a lifestyle modification program is questionable given the large proportion of the population screened-in using the current minimum cut-off of ≥12. AUSDRISK should be used in conjunction with oral glucose tolerance testing, fasting glucose, or glycated hemoglobin to identify those individuals at highest risk of progression to type 2 diabetes, who should be the primary targets for lifestyle modification. PMID:26468399

  16. A pilot study evaluating a one-session attention modification training to decrease overeating in obese children

    PubMed Central

    Boutelle, Kerri N.; Kuckertz, Jennie M.; Carlson, Jordan; Amir, Nader

    2014-01-01

    There are a number of neurocognitive and behavioral mechanisms that contribute to overeating and obesity, including an attentional bias to food cues. Attention modification programs, which implicitly train attention away from specific cues, have been used in anxiety and substance abuse, and could logically be applied to food cues. The purpose of this study was to evaluate the initial efficacy of a single session attention modification training for food cues (AMP) on overeating in overweight and obese children. Twenty–four obese children who eat in the absence of hunger participated in two visits and were assigned to an attention modification program (AMP) or attentional control program (ACC). The AMP program trained attention away 100% of the time from food words to neutral words. The ACC program trained attention 50% of the time to neutral and 50% of the time to food. Outcome measures included the eating in the absence of hunger free access session, and measures of craving, liking and salivation. Results revealed significant treatment effects for EAH percent and EAH kcal (group by time interactions p < .05). Children in the ACC condition showed a significant increase over time in the number of calories consumed in the free access session (within group t=3.09, p=.009) as well as the percent of daily caloric needs consumed in free access (within group t=3.37, p=.006), whereas children in the AMP group demonstrated slight decreases in these variables (within group t=−0.75 and −0.63). There was a trend suggesting a beneficial effect of AMP as compared to ACC for attentional bias (group by time interaction p=.073). Changes in craving, liking and saliva were not significantly different between groups (ps=.178 to .527). This is the first study to demonstrate that an AMP program can influence eating in obese children. Larger studies are needed to replicate and extend these results. PMID:24512975

  17. Evaluation of albumin structural modifications through cobalt-albumin binding (CAB) assay.

    PubMed

    Lee, Eunyoung; Eom, Ji-Eun; Jeon, Kyung-Hwa; Kim, Tae Hee; Kim, Eunnam; Jhon, Gil-Ja; Kwon, Youngjoo

    2014-03-01

    Human serum albumin (HSA) is the most abundant protein in the human body. HSA injections prepared by fractionating human blood have mainly covered the demand for albumin to treat hypoalbuminemia, the state of low concentration of albumin in blood. HSA in solution may exist in various forms such as monomers, oligomers, polymers, or as mixtures, and its conformational change and/or aggregation may occur easily. Considering these characteristics, there is a great chance of modification and polymer formation during the preparation processes of albumin products, especially injections. The albumin cobalt binding (ACB) test reported by Bar-Or et al. was originally designed to detect ischemia modified albumin (IMA), which contains the modified HSA N-terminal sequence by cleavage of the last two amino acids. In this study, we developed a cobalt albumin binding (CAB) assay to correct the flaws of the ACB test with improving the sensitivity and precision. The newly developed CAB assay easily detects albumin configuration alterations and may be able to be used in developing a quality control method for albumin and its pharmaceutical formulations including albumin injections.

  18. A proposed systems approach to the evaluation of integrated palliative care

    PubMed Central

    2010-01-01

    Background There is increasing global interest in regional palliative care networks (PCN) to integrate care, creating systems that are more cost-effective and responsive in multi-agency settings. Networks are particularly relevant where different professional skill sets are required to serve the broad spectrum of end-of-life needs. We propose a comprehensive framework for evaluating PCNs, focusing on the nature and extent of inter-professional collaboration, community readiness, and client-centred care. Methods In the absence of an overarching structure for examining PCNs, a framework was developed based on previous models of health system evaluation, explicit theory, and the research literature relevant to PCN functioning. This research evidence was used to substantiate the choice of model factors. Results The proposed framework takes a systems approach with system structure, process of care, and patient outcomes levels of consideration. Each factor represented makes an independent contribution to the description and assessment of the network. Conclusions Realizing palliative patients' needs for complex packages of treatment and social support, in a seamless, cost-effective manner, are major drivers of the impetus for network-integrated care. The framework proposed is a first step to guide evaluation to inform the development of appropriate strategies to further promote collaboration within the PCN and, ultimately, optimal palliative care that meets patients' needs and expectations. PMID:20459734

  19. Proposed modifications to the RCRA post-closure permit for the Chestnut Ridge Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to several conditions of the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Chestnut Ridge Hydrogeologic Regime (CRHR) (permit number TNHW-088, EPA ID No. TN3 89 009 0001). These permit conditions define the requirements for RCRA post-closure detection groundwater monitoring at the Chestnut Ridge Sediment Disposal Basin (CRSDB) and Kerr Hollow Quarry (KHQ), and RCRA post-closure corrective action groundwater monitoring at the Chestnut Ridge Security Pits (CRSPs). Modification of these PCP conditions is requested to: (1) clarify the planned integration of RCRA post-closure corrective action groundwater monitoring at the CRSPs with the monitoring program to be established in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) record of decision (ROD), (2) revise several of the current technical requirements for groundwater monitoring based on implementation of the RCRA monitoring programs during 1996, (3) replace several of the technical procedures included in the PCP with updated versions recently issued by the Y-12 Plant Groundwater Protection Program (GWPP), and (4) correct inaccurate regulatory citations and references to permit conditions and permit attachments. With these modifications, the Y- 12 Plant will continue to meet the full intent of all regulatory obligations for post-closure care of these facilities. Section 2 provides the technical justification for each proposed permit modification. Section 3.0 contains proposed changes to Section II of the PCP. Modifications to site-specific permit conditions are presented in Section 4.0 (CRSDB), Section 5.0 (CRSPs), and Section 6.0 (KHQ). Sections 7.0 and 8.0 reference updated and revised procedures for groundwater sampling, and monitoring well plugging and abandonment, respectively. Appendix A includes all proposed revisions to the permit attachments.

  20. Evaluation of enamel surface modification using PS-OCT after laser treatment to increase resistance to demineralization

    NASA Astrophysics Data System (ADS)

    Kim, Jin Wan; Chan, Kenneth H.; Fried, Daniel

    2016-02-01

    At laser intensities below ablation, carbonated hydroxyapatite in enamel is converted into a purer phase hydroxyapatite with increased acid resistance. Previous studies suggested the possibility of achieving the conversion without surface modification. This study attempts to evaluate the thresholds for the modification without additional changes in physical and optical properties of the enamel. Bovine specimens were irradiated using an RF-excited CO2 laser operating at 9.4-μm with a pulse duration of 26- μs, pulse repetition rates of 100-1000 Hz, with a Gaussian spatial beam profile - 1.4 mm in diameter. After laser treatment, the samples were subjected to acid demineralization for 48 hours to simulate acidic intraoral conditions of a caries attack. The resulting demineralization and erosion were assessed using polarization sensitive OCT (PS-OCT) and 3D digital microscopy. The images from digital microscopy demonstrated a clear delineation between laser protected zones without visual changes and zones with higher levels of demineralization and erosion. Distinct changes in the surface morphology were found within the laser treated area in accordance with the Gaussian spatial beam profile. There was significant protection from the laser in areas that were not visually altered.

  1. Evaluation of enamel surface modification using PS-OCT after laser treatment to increase resistance to demineralization

    PubMed Central

    Kim, Jin Wan; Chan, Kenneth H.; Fried, Daniel

    2016-01-01

    At laser intensities below ablation, carbonated hydroxyapatite in enamel is converted into a purer phase hydroxyapatite with increased acid resistance. Previous studies suggested the possibility of achieving the conversion without surface modification. This study attempts to evaluate the thresholds for the modification without additional changes in physical and optical properties of the enamel. Bovine specimens were irradiated using an RF-excited CO2 laser operating at 9.4-µm with a pulse duration of 26-µs, pulse repetition rates of 100–1000 Hz, with a Gaussian spatial beam profile - 1.4 mm in diameter. After laser treatment, the samples were subjected to acid demineralization for 48 hours to simulate acidic intraoral conditions of a caries attack. The resulting demineralization and erosion were assessed using polarization sensitive OCT (PS-OCT) and 3D digital microscopy. The images from digital microscopy demonstrated a clear delineation between laser protected zones without visual changes and zones with higher levels of demineralization and erosion. Distinct changes in the surface morphology were found within the laser treated area in accordance with the Gaussian spatial beam profile. There was significant protection from the laser in areas that were not visually altered. PMID:27006523

  2. SDS-PAGE and IR spectroscopy to evaluate modifications in the viral protein profile induced by a cationic porphyrinic photosensitizer.

    PubMed

    Costa, Liliana; Esteves, Ana Cristina; Correia, António; Moreirinha, Catarina; Delgadillo, Ivonne; Cunha, Ângela; Neves, Maria G P S; Faustino, Maria A F; Almeida, Adelaide

    2014-12-01

    Reactive oxygen species can be responsible for microbial photodynamic inactivation due to its toxic effects, which include severe damage to proteins, lipids and nucleic acids. In this study, the photo-oxidative modifications of the proteins of a non-enveloped T4-like bacteriophage, induced by the cationic porphyrin 5,10,15-tris(1-methylpyridinium-4-yl)-20-(pentafluorophenyl)porphyrin tri-iodide were evaluated. Two methods were used: sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and infrared spectroscopy. SDS-PAGE analysis showed that the phage protein profile was considerably altered after photodynamic treatment. Seven protein bands putatively corresponding to capsid and tail tube proteins were attenuated and two other were enhanced. Infrared spectroscopy confirmed the time-dependent alteration on the phage protein profile detected by SDS-PAGE, indicative of a response to oxidative damage. Infrared analysis showed to be a promising and rapid screening approach for the analysis of the modifications induced on viral proteins by photosensitization. In fact, one single infrared spectrum can highlight the changes induced to all viral molecular structures, overcoming the delays and complex protocols of the conventional methods, in a much simple and cost effective way.

  3. Evaluation of dredged material proposed for ocean Disposal from Shoal Harbor/Compton Creek Project Area

    SciTech Connect

    Gardiner, W.W.; Borde, A.B.; Nieukirk, S.L.; Barrows, E.S.; Gruendell, B.D.; Word, J.Q.

    1996-10-01

    The objective of the Shoal Harbor/Compton Creek Project was to evaluate proposed dredged material from the Shoal harbor/Compton Creek Project Area in Belford and Monmouth, New Jersey to determine its suitability for unconfined ocean disposal at the Mud Dump Site. This was one of five waterways that the US Army Corps of Engineers- New York District requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in May 1995. The evaluation of proposed dredged material from the Shoal Harbor/Compton Creek Project area consisted of bulk chemical analyses, chemical analyses of dredging site water and elutriate, benthic and water-column acute toxicity tests and bioaccumulation studies. Eleven core samples were analyzed or grain size, moisture content, and total organic carbon. Other sediments were evaluated for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Dredging site water and elutriate water were analyzed for metals, pesticides, and PCBs.

  4. Evaluating the Role of Epigenetic Histone Modifications in the Metabolic Memory of Type 1 Diabetes

    PubMed Central

    Miao, Feng; Chen, Zhuo; Genuth, Saul; Paterson, Andrew; Zhang, Lingxiao; Wu, Xiwei; Li, Sierra Min; Cleary, Patricia; Riggs, Arthur; Harlan, David M.; Lorenzi, Gayle; Kolterman, Orville; Sun, Wanjie; Lachin, John M.; Natarajan, Rama

    2014-01-01

    We assessed whether epigenetic histone posttranslational modifications are associated with the prolonged beneficial effects (metabolic memory) of intensive versus conventional therapy during the Diabetes Control and Complications Trial (DCCT) on the progression of microvascular outcomes in the long-term Epidemiology of Diabetes Interventions and Complications (EDIC) study. We performed chromatin immunoprecipitation linked to promoter tiling arrays to profile H3 lysine-9 acetylation (H3K9Ac), H3 lysine-4 trimethylation (H3K4Me3), and H3K9Me2 in blood monocytes and lymphocytes obtained from 30 DCCT conventional treatment group subjects (case subjects: mean DCCT HbA1c level >9.1% [76 mmol/mol] and progression of retinopathy or nephropathy by EDIC year 10 of follow-up) versus 30 DCCT intensive treatment subjects (control subjects: mean DCCT HbA1c level <7.3% [56 mmol/mol] and without progression of retinopathy or nephropathy). Monocytes from case subjects had statistically greater numbers of promoter regions with enrichment in H3K9Ac (active chromatin mark) compared with control subjects (P = 0.0096). Among the patients in the two groups combined, monocyte H3K9Ac was significantly associated with the mean HbA1c level during the DCCT and EDIC (each P < 2.2E-16). Of note, the top 38 case hyperacetylated promoters (P < 0.05) included >15 genes related to the nuclear factor-κB inflammatory pathway and were enriched in genes related to diabetes complications. These results suggest an association between HbA1c level and H3K9Ac, and a possible epigenetic explanation for metabolic memory in humans. PMID:24458354

  5. Engineering evaluation of the proposed boiler addition for Minnegasco Energy Center, Minneapolis, Minnesota. Final draft report

    SciTech Connect

    Abendroth, H.R.; Poon, A.

    1981-03-16

    The results are reported of a technical evaluation of alternate fuels for the proposed oil and natural gas fired No. 3 boiler at the Minnegasco Energy Center (MEC) located in Minneapolis, Minnesota. This report has been prepared for the Department of Energy, Office of Fuels Conversion for their use in considering an alternate fuel exemption petition submitted by MEC. The fuels considered for the proposed boiler include oil, natural gas, bituminous coal, petroleum coke/coal mixture, refuse-derived fuel (RDF), coal-oil mixtures, and coal/oil dual fuel fired. The purchase of steam from the Northern States Power Company (NSPCo) was also considered as an alternative to construction of another boiler at MEC. Evaluation of each fuel included review of the overall plant design, estimates of capital and O and M costs, salvage value, useful life, and quantities of solid waste produced. The MEC supplies steam and chilled water to the downtown Minneapolis area for building heating and cooling using two presently owned and operated 200,000 lb/h oil/natural gas fired boilers. If the proposed boiler is permitted to burn oil and natural gas, it will be identical in design to the existing boilers. The evaluation showed that the use of oil, natural gas, coal, petroleum coke-coal mixtures, coal-oil mixtures, and coal/oil dual fuel firing appear technically feasible as fuel choices for the proposed boiler. The purchase of steam from the NSPCo appears feasible as an alternative to the installation of a new boiler at the MEC. Offsite storage space would be required for receiving and storing coal, petroleum coke, or RDF Offsite fuel preparation facilities are required for preparing petroleum coke-coal mixtures and RDF.

  6. Evaluation of vegetation effects on the generation and modification of mesoscale circulations

    NASA Technical Reports Server (NTRS)

    Segal, M.; Avissar, R.; Pielke, R. A.; Mccumber, M. C.

    1988-01-01

    The effects of the presence of vegetation cover on modifying sea breeze and thermally induced upslope flows during daytime were investigated, and the possibility of the generation of mesoscale circulations due to nonuniform vegetation cover was evaluated. Scale analysis and numerical model simulations were used to provide quantitative evaluations of the circulations involved in the two vagetation effects, using several illustrative cases. The cases considered demonstrate that the impact of vegetated surfaces is highly dependent on the environmental conditions as well as vegetation characteristics.

  7. Behavior Modification for Obesity: The Evaluation of Exercise, Contingency Management, and Program Adherence.

    ERIC Educational Resources Information Center

    And Others; Stalonas, Peter M., Jr.

    1978-01-01

    Investigated behavioral programs for obesity. Exercise and self-managed contingency components were compared using obese subjects who were evaluated after treatment and follow-up. Significant weight loss was observed at termination. The influence of exercise at follow-up was noticeable. Subjects engaged in behaviors, yet behaviors were not related…

  8. Fertility Modification Thesaurus with Focus on Evaluation of Family Planning Programs.

    ERIC Educational Resources Information Center

    Speert, Kathryn H.; Wishik, Samuel M.

    The Division of Social and Administrative Sciences of the International Institute for the Study of Human Reproduction at Columbia University has compiled this list of terms used in indexing the literature for family planning program evaluation. This thesaurus should prove of direct use to the indexer of documents describing family planning program…

  9. Synthetic Modification of 9α- and 9β-Hydroxyparthenolide by Heck or Acylation Reactions and Evaluation of Cytotoxic Activities.

    PubMed

    El Bouakher, Abderrahman; Jismy, Badr; Allouchi, Hassan; Duverger, Eric; Barkaoui, Latifa; El Hakmaoui, Ahmed; Daniellou, Richard; Guillaumet, Gérald; Akssira, Mohamed

    2016-12-05

    Motivated by the widely reported anticancer activity of parthenolides and their derivatives, a series of new substituted parthenolides was efficiently synthesized. Structural modifications were performed at the C-9 and C-13 positions of 9α- and 9β-hydroxyparthenolide, which were isolated from the aerial parts of Anvillea radiata. Twenty-one derivatives were synthesized and evaluated for their in vitro cytotoxic activity against HS-683, SK-MEL-28, A549, and MCF-7 human cancer cell lines using the MTT colorimetric assay. Among the derivatives, seven exhibited excellent activity compared to 5-fluorouracil and etoposide against the four cell lines tested, with IC50 values ranging from 1.1 to 9.4 µM.

  10. Design and Evaluation of Modifications to the NASA Langley Flow Impedance Tube

    NASA Technical Reports Server (NTRS)

    Jones, Michael G.; Watson, Willie R.; Parrott, Tony L.; Smith, Charles D.

    2004-01-01

    The need to minimize fan noise radiation from commercial aircraft engine nacelles continues to provide an impetus for developing new acoustic liner concepts. If the full value of such concepts is to be attained, an understanding of grazing flow effects is crucial. Because of this need for improved understanding of grazing flow effects, the NASA Langley Research Center Liner Physics Group has invested a large effort over the past decade into the development of a 2-D finite element method that characterizes wave propagation through a lined duct. The original test section in the Langley Grazing IncidenceTube was used to acquire data needed for implementation of this finite element method. This test section employed a stepper motor-driven axial-traversing bar, embedded in the wall opposite the test liner, to position a flush-mounted microphone at pre-selected locations. Complex acoustic pressure data acquired with this traversing microphone were used to educe the acoustic impedance of test liners using this 2-D finite element method and a local optimization technique. Results acquired in this facility have been extensively reported, and were compared with corresponding results from various U.S. aeroacoustics laboratories in the late 1990 s. Impedance data comparisons acquired from this multi-laboratory study suggested that it would be valuable to incorporate more realistic 3-D aeroacoustic effects into the impedance eduction methodology. This paper provides a description of modifications that have been implemented to facilitate studies of 3-D effects. The two key features of the modified test section are (1) the replacement of the traversing bar and its flush-mounted microphone with an array of 95 fixed-location microphones that are flush-mounted in all four walls of the duct, and (2) the inclusion of a suction device to modify the boundary layer upstream of the lined portion of the duct. The initial results achieved with the modified test section are provided in this

  11. Evaluation and Analysis of the ANSI X3T9.5 (FDDI) PMD and Proposed SMF-PMD as Influenced by Various Fiber Link Characteristics

    NASA Technical Reports Server (NTRS)

    Wernicki, M. Chris

    1991-01-01

    The purpose of this project is to evaluate the operational parameters of the Kennedy Space Center (KSC) fiber optic cable plant. The evaluation is based on the Fiber Distributed Data Interface (FDDI) Physical Medium Dependent (PMD) and Single Mode Fiber (SMF) PMD standards. From the KSC fiber profile, it would be necessary to develop the modifications needed in existing FDDI PMD and proposed SMF-PMD standards to provide for FDDI implementation and operation at KSC. This analysis should examine the major factors that influence the operating conditions of the KSC fiber plant. These factors would include, but are not limited to the number and type of connectors, attenuation and dispersion characteristics of the fiber, non-standard fiber sizes, modal bandwidth, and many other relevant or significant fiber plant characteristics that effect FDDI characteristics. This analysis is needed to gain a better understanding of overall impact that each of these factors have on FDDI performance at KSC.

  12. 71 FR 55515 - Safety Evaluation Report for the Proposed American Centrifuge Plant in Piketon, OH, NUREG-1851...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2006-09-22

    ..., nuclear criticality safety, chemical process safety, fire safety, emergency management, environmental... COMMISSION Safety Evaluation Report for the Proposed American CentrifugePlant in Piketon, OH, NUREG-1851... Availability of Safety Evaluation Report. SUMMARY: Notice is hereby given that the Nuclear...

  13. Ecological evaluation of proposed dredged material from the Point Frazer Bend Reach, Winyah Bay, South Carolina

    SciTech Connect

    Gardiner, W.W.; Ward, J.A.; Word, J.Q.

    1995-02-01

    The port of Georgetown, South Carolina, is served by navigational channels within Winyah Bay and the lower Sampit River. Dredging is required to maintain these waterways and to facilitate normal shipping traffic. Prior to dredging, ecological evaluations must be conducted to determine the suitability of the proposed dredged material for open-ocean disposal. These evaluations are to be performed under Section 103 of the Marine Protection, Research, and, Sanctuaries Act of 1972 (MPRSA), following the testing protocols presented in Evaluation of Dredged Material Proposed for Ocean Disposal Testing Manual, hereafter referred to as the 1991 Implementation Manual. The Charleston Intensive Project is a reevaluation of sediments collected from two stations (IH-2 and IH-3) in the Frazier Point Bend reach of the Winyah Bay channel. Reference sediment was also collected from site IH-R2, just south of Hare Island. The results of physical/chemical analyses indicated that some contaminants of concern were present in test treatments representing dredged material when compared with the reference treatment IH-R2. The results of this study indicate that, based on the acute toxicity and chemical analyses, dredged material represented by these test treatments is suitable for open-ocean disposal.

  14. Evaluation of dredged material proposed for ocean disposal from South Brother Island Channel, New York

    SciTech Connect

    Barrows, E.S.; Gardiner, W.W.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-09-01

    South Brother Island Channel was one of seven waterways that the US Army Crops of Engineers-New York District requested the Battelle/Marine Sciences Laboratory to sample and evaluate for dredging and disposal. Tests and analyses were conducted on South Brother Island Channel sediment core samples and evaluations were performed. The evaluation of proposed dredged material from South Brother Island Channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Souther Brother Island Channel were analyzed for grain size, moisture content, and total organic carbon. a composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Site water and elutriate water, prepared from the suspended-particle phase of South Brother Island Channel sediment, were analyzed for metals, pesticides, and PCBs.

  15. Evaluation of dredged material proposed for ocean disposal from Westchester Creek project area, New York

    SciTech Connect

    Pinza, M.R.; Gardiner, W.W.; Barrows, E.S.; Borde, A.B.

    1996-11-01

    The objective of the Westchester Creek project was to evaluate proposed dredged material from this area to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Westchester Creek was one of five waterways that the US Army Corps of Engineers- New York District (USACE-NYD) requested the Battelle/Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in May 1995. The evaluation of proposed dredged material from the Westchester Creek project area consisted of bulk sediment chemical analyses, chemical analyses of dredging site water and elutriate, benthic acute and water-column toxicity tests, and bioaccumulation studies. Thirteen individual sediment core samples were collected from this area and analyzed for grain size, moisture content, and total organic carbon (TOC). One composite sediment sample representing the Westchester Creek area to be dredged, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4-dichlorobenzene. Dredging site water and elutriate water, which is prepared from the suspended- particulate phase (SPP) of the Westchester Creek sediment composite, was analyzed for metals, pesticides, and PCBS.

  16. A method proposal for cumulative environmental impact assessment based on the landscape vulnerability evaluation

    SciTech Connect

    Pavlickova, Katarina; Vyskupova, Monika

    2015-01-15

    Cumulative environmental impact assessment deals with the occasional use in practical application of environmental impact assessment process. The main reasons are the difficulty of cumulative impact identification caused by lack of data, inability to measure the intensity and spatial effect of all types of impacts and the uncertainty of their future evolution. This work presents a method proposal to predict cumulative impacts on the basis of landscape vulnerability evaluation. For this purpose, qualitative assessment of landscape ecological stability is conducted and major vulnerability indicators of environmental and socio-economic receptors are specified and valuated. Potential cumulative impacts and the overall impact significance are predicted quantitatively in modified Argonne multiple matrixes while considering the vulnerability of affected landscape receptors and the significance of impacts identified individually. The method was employed in the concrete environmental impact assessment process conducted in Slovakia. The results obtained in this case study reflect that this methodology is simple to apply, valid for all types of impacts and projects, inexpensive and not time-consuming. The objectivity of the partial methods used in this procedure is improved by quantitative landscape ecological stability evaluation, assignment of weights to vulnerability indicators based on the detailed characteristics of affected factors, and grading impact significance. - Highlights: • This paper suggests a method proposal for cumulative impact prediction. • The method includes landscape vulnerability evaluation. • The vulnerability of affected receptors is determined by their sensitivity. • This method can increase the objectivity of impact prediction in the EIA process.

  17. Hyperthermic tissue sealing devices: a proposed histopathologic protocol for standardizing the evaluation of thermally sealed vessels

    NASA Astrophysics Data System (ADS)

    Livengood, Ryan H.; Vos, Jeffrey A.; Coad, James E.

    2011-03-01

    Hyperthermic tissue sealing devices are advancing modern laparoscopy and other minimally invasive surgical approaches. Histopathologic evaluation of thermally sealed vessels can provide important information on their associated tissue effects and reactions. However, a standardized systematic approach has not been historically used in the literature. This paper proposes a histologic approach for the analysis of thermally sealed vessels and their basis of hemostasis, including thermal tissue changes, healing, and thrombosis. Histologic evaluation during the first week (Days 3-7) can assess the seal's primary tissue properties. These parameters include the thermal seal's length, architecture, tissue layers involved, adventitial collagen denaturation length, entrapped vapor or blood pockets, tissue homogenization and thermal tissue injury zones. While the architectural features can be assessed in Day 0-3 specimens, the latter thermal injury zones are essentially not assessable in Day 0-3 specimens. Day 14 specimens can provide information on the early healing response to the sealed vessel. Day 30 and longer specimens can be used to evaluate the seal's healing reactions. Assessment of the healing response should include seal site inflammation, granulation tissue, necrosis resorption, fibroproliferative scar healing, and thrombus organization. In order to accurately evaluate these parameters, careful specimen orientation, embedding and multiple histologic sections across the entire seal width are required. When appropriate in vivo post-treatment times are used, thermal vessel seals can be evaluated with routine light microscopy and common histologic staining methods.

  18. Evaluating Academic Scientists Collaborating in Team-Based Research: A Proposed Framework.

    PubMed

    Mazumdar, Madhu; Messinger, Shari; Finkelstein, Dianne M; Goldberg, Judith D; Lindsell, Christopher J; Morton, Sally C; Pollock, Brad H; Rahbar, Mohammad H; Welty, Leah J; Parker, Robert A

    2015-10-01

    Criteria for evaluating faculty are traditionally based on a triad of scholarship, teaching, and service. Research scholarship is often measured by first or senior authorship on peer-reviewed scientific publications and being principal investigator on extramural grants. Yet scientific innovation increasingly requires collective rather than individual creativity, which traditional measures of achievement were not designed to capture and, thus, devalue. The authors propose a simple, flexible framework for evaluating team scientists that includes both quantitative and qualitative assessments. An approach for documenting contributions of team scientists in team-based scholarship, nontraditional education, and specialized service activities is also outlined. Although biostatisticians are used for illustration, the approach is generalizable to team scientists in other disciplines.The authors offer three key recommendations to members of institutional promotion committees, department chairs, and others evaluating team scientists. First, contributions to team-based scholarship and specialized contributions to education and service need to be assessed and given appropriate and substantial weight. Second, evaluations must be founded on well-articulated criteria for assessing the stature and accomplishments of team scientists. Finally, mechanisms for collecting evaluative data must be developed and implemented at the institutional level. Without these three essentials, contributions of team scientists will continue to be undervalued in the academic environment.

  19. Evaluation of dredged material proposed for ocean disposal from Hackensack River Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Barrows, E.S.; Borde, A.B.

    1997-01-01

    The objective of the bioassay reevaluation of the Hackensack River Federal Project was to reperform toxicity testing on proposed dredged material with current ammonia reduction protocols. Hackensack River was one of four waterways sampled and evaluated for dredging and disposal in April 1993. Sediment samples were re-collected from the Hackensack River Project area in August 1995. Tests and analyses were conducted according to the manual developed by the USACE and the U.S. Environmental Protection Agency (EPA), Evaluation of Dredged Material Proposed for Ocean Disposal (Testing Manual), commonly referred to as the {open_quotes}Green Book,{close_quotes} and the regional manual developed by the USACE-NYD and EPA Region II, Guidance for Performing Tests on Dredged Material to be Disposed of in Ocean Waters. The reevaluation of proposed dredged material from the Hackensack River project area consisted of benthic acute toxicity tests. Thirty-three individual sediment core samples were collected from the Hackensack River project area. Three composite sediments, representing each reach of the area proposed for dredging, were used in benthic acute toxicity testing. Benthic acute toxicity tests were performed with the amphipod Ampelisca abdita and the mysid Mysidopsis bahia. The amphipod and mysid benthic toxicity test procedures followed EPA guidance for reduction of total ammonia concentrations in test systems prior to test initiation. Statistically significant acute toxicity was found in all three Hackensack River composites in the static renewal tests with A. abdita, but not in the static tests with M. bahia. Statistically significant acute toxicity and a greater than 20% increase in mortality over the reference sediment was found in the static renewal tests with A. abdita. Statistically significant mortality 10% over reference sediment was observed in the M. bahia static tests. 5 refs., 2 figs., 2 tabs.

  20. Evaluation of dredged material proposed for ocean disposal from Arthur Kill Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Barrows, E.S.; Borde, A.B.

    1997-01-01

    The objective of the bioassay reevaluation of Arthur Kill Federal Project was to reperform toxicity testing on proposed dredged material following current ammonia reduction protocols. Arthur Kill was one of four waterways sampled and evaluated for dredging and disposal in April 1993. Sediment samples were recollected from the Arthur Kill Project areas in August 1995. Tests and analyses were conducted according to the manual developed by the USACE and the U.S. Environmental Protection Agency (EPA), Evaluation of Dredged Material Proposed for Ocean Disposal (Testing Manual), commonly referred to as the {open_quotes}Green Book,{close_quotes} and the regional manual developed by the USACE-NYD and EPA Region II, Guidance for Performing Tests on Dredged Material to be Disposed of in Ocean Waters. The reevaluation of proposed dredged material from the Arthur Kill project areas consisted of benthic acute toxicity tests. Thirty-three individual sediment core samples were collected from the Arthur Kill project area. Three composite sediments, representing each reach of the area proposed for dredging, was used in benthic acute toxicity testing. Benthic acute toxicity tests were performed with the amphipod Ampelisca abdita and the mysid Mysidopsis bahia. The amphipod and mysid benthic toxicity test procedures followed EPA guidance for reduction of total ammonia concentrations in test systems prior to test initiation. Statistically significant acute toxicity was found in all Arthur Kill composites in the static renewal tests with A. abdita, but not in the static tests with M. bahia. Statistically significant acute toxicity and a greater than 20% increase in mortality over the reference sediment was found in the static renewal tests with A. abdita. M. bahia did not show statistically significant acute toxicity or a greater than 10% increase in mortality over reference sediment in static tests. 5 refs., 2 figs., 2 tabs.

  1. Evaluation of the proposed pilot groundwater pump and treat demonstration for the Paducah Gaseous Diffusion Plant

    SciTech Connect

    Bodenstein, G.W.; Bonczek, R.R.; Early, T.O.; Hale, T.B.; Huff, D.D.; Nickelson, M.D.; Rightmire, C.T.

    1992-11-01

    This report contains the evaluation and recommendations of a Groundwater Corrective Actions Review Team. The primary goal is to evaluate the technical merit of and the need to implement a proposed groundwater pump-and-treat demonstration project for the Northwest contaminant plume at Paducah, Kentucky. A key distinction recognized by the review team is that the proposed project is intended to be a full-scale hydraulic containment of contaminants migrating from the sources of the plume, not plume remediation. The key questions incorporated into this plan are whether (1) dense, nonaqueous-phase liquids (DNAPLS) are present in the Regional Gravel Aquifer (RGA) at the source of the plume and (2) [sup 99]Tc removal must be included as part of any groundwater treatment process. The first question cannot be answered until the contaminant sources are better defined; the second question requires further risk assessment and/or a policy decision by DOE. Technical evaluation by the review team suggests that the recommended course of action be to modify the proposed work plan to include accurate identification of the sources of contaminants and vertical distribution of contaminants within the Northwest plume before a decision is made on the preferred source-control option. If DNAPLs are not present in the RGA, removal or containment of the sources is recommended. If DNAPLs are present, then hydraulic containment will be required. Finally, the review team recognizes that it is necessary to initiate a more comprehensive analysis of sitewide remediation needs to create links between action taken for the Northwest plume and action taken for other contamination sites at PGPD.

  2. Evaluation of dredged material proposed for ocean disposal from Eastchester Project Area, New York

    SciTech Connect

    Antrim, L.D.; Pinza, M.R.; Barrows, E.S.; Gardiner, W.W.; Tokos, J.J.S.; Gruendell, B.D.; Word, J.Q.

    1996-07-01

    The objective of the Eastchester project (Federal Project [FP] No. 6) was to evaluate proposed dredged material from the Eastchester project area in the Hutchinson River to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Eastchester was one of seven waterways that the U. S. Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle/Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in March 1994. The evaluation of proposed dredged material from the Eastchester project area consisted of bulk sediment chemical analyses, chemical analyses of dredging site water and elutriate, water- column and benthic acute toxicity tests, and bioaccumulation studies. Eighteen individual sediment core samples collected from the Eastchester project area were analyzed for grain size, moisture content, and total organic carbon (TOC). Two composite sediment samples, representing the upstream and lower reaches of the area proposed for dredging, were analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4- dichlorobenzene. Dredging site water and elutriate water, which is prepared from the suspended-particulate phase (SPP) of the two Eastchester sediment composites, were analyzed for metals, pesticides, and PCBS. An additional 1 1 composite samples were created for the USACE-New England Division (USACE-NED) using the same 18 Eastchester core samples but combined into different composites. These composites were analyzed for metals, chlorinated pesticides, PCB congeners, PAHS, and 1,4-dichlorobenzene. Water-column or SPP toxicity tests were performed along with bioaccumulation tests.

  3. Permit application modifications

    SciTech Connect

    1995-11-01

    This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils.

  4. Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20.

    PubMed

    Riva, Elena; Comi, Daniela; Borrelli, Stella; Colombo, Francesco; Danieli, Bruno; Borlak, Jurgen; Evensen, Lasse; Lorens, James B; Fontana, Gabriele; Gia, Ornella Maria; Via, Lisa Dalla; Passarella, Daniele

    2010-12-15

    The preparation and biological evaluation of a novel series of dimeric camptothecin derivatives are described. All the new compounds showed a significant ability to inhibit human tumor cell growth with IC(50) values ranging from 0.03 to 12.2 μM. The interference with the activity of the nuclear enzymes topoisomerases has been demonstrated, highlighting the poison effect of one of the obtained byproducts toward topoisomerase I. A moderate antiangiogenic activity has been demonstrated for one of the obtained compounds. Moreover, the effects of four new compounds on caspases activity and ROS generation have been studied on transgenic mouse cell.

  5. A Quick Method for Evaluating the Merits of a Proposed Low Sonic Boom Concept

    NASA Technical Reports Server (NTRS)

    Mack, Robert J.

    2003-01-01

    The characteristics of a proposed low-boom aircraft concept cannot be adequately assessed unless it is given an extensive, time-consuming, mission-performance, and sonic-boom analyses. So, it would be useful to have a method for performing a quick first-order sonic-boom and mission-range analysis. The evaluation method outlined in this report has the attributes of being both fast and reasonably accurate. It can also be used as a design tool to estimate the sonic-boom ground overpressures, mission range, and beginning-cruise weight of a new low-boom concept during the first stages of preliminary design.

  6. Ecological evaluation of proposed dredged material from Winyah Bay, South Carolina

    SciTech Connect

    Ward, J.A.; Gardiner, W.W.; Pinza, M.R.; Word, J.Q.

    1993-10-01

    The navigational channels of Winyah Bay, Georgetown Harbor, South Carolina require dredging to enable normal shipping traffic to use these areas. Before dredging, environmental assessments must be conducted to determine the suitability of this dredged sediment for unconfined, open-water disposal. The Charleston, South Carolina District Office of the US Army Corps of Engineers (USACE) requested that the Battelle/Marine Science Laboratory (MSL) collect sediment samples and conduct the required physical/chemical, toxicological, and bioaccumulation evaluations as required in the 1991 Implementation Manual. This report is intended to provide information required to address potential ecological effects of the Entrance Channel and Inner Harbor sediments proposed disposal in the ocean.

  7. A proposal for the curriculum and evaluation for training rural family physicians in enhanced surgical skills

    PubMed Central

    Caron, Nadine; Iglesias, Stuart; Friesen, Randall; Berjat, Vanessa; Humber, Nancy; Falk, Ryan; Prins, Mark; Haines, Victoria Vogt; Geller, Brian; Janke, Fred; Woollard, Robert; Batchelor, Bret; Van Bussel, Jared

    2015-01-01

    Summary Rural western Canada relies heavily on family physicians with enhanced surgical skills (ESS) for surgical services. The recent decision by the College of Family Physicians of Canada (CFPC) to recognize ESS as a “community of practice” section offers a potential home akin to family practice anesthesia and emergency medicine. To our knowledge, however, a skill set for ESS in Canada has never been described formally. In this paper the Curriculum Committee of the National ESS Working Group proposes a generic curriculum for the training and evaluation of the ESS skill set. PMID:26574835

  8. 75 FR 65700 - 60-Day Notice of Proposed Information Collection: R/PPR Evaluation and Measurement Unit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... Notice of Proposed Information Collection: R/PPR Evaluation and Measurement Unit, Evaluation Survey... of Information Collection: R/PPR Evaluation and Measurement Unit Survey Question Bank. OMB Control... Public Diplomacy and Public Affairs' Office of Policy, Planning and Resources Evaluation and...

  9. [Implementation of multi-strategy programs: a proposal for an evaluation matrix].

    PubMed

    Magalhães, Rosana

    2014-07-01

    The programs that seek to achieve comprehensive changes involve the relationship between different public policies, understanding the diversity of social demands in each context and enhancing a participative dynamic. Due to the complexity of these experiences, it is important to review the traditional perspectives and discuss alternatives. Based on the analytical framework of the so-called theory-driven evaluation, the core focus of which is the analysis of the validity of the concepts that link processes and results and the exploratory case study of the qualitative character of the federal Bolsa Familia cash transfer program, the paper proposes a methodological matrix as its main result to support the evaluation of interventions related to health promotion, food security and poverty reduction.

  10. Evaluating Academic Scientists Collaborating in Team-Based Research: A Proposed Framework

    PubMed Central

    Mazumdar, Madhu; Messinger, Shari; Finkelstein, Dianne M.; Goldberg, Judith D.; Lindsell, Christopher J.; Morton, Sally C.; Pollock, Brad H.; Rahbar, Mohammad H.; Welty, Leah J.; Parker, Robert A.

    2015-01-01

    Criteria for evaluating faculty are traditionally based on a triad of scholarship, teaching, and service. Research scholarship is often measured by first or senior authorship on peer-reviewed scientific publications and being principal investigator on extramural grants. Yet scientific innovation increasingly requires collective rather than individual creativity, which traditional measures of achievement were not designed to capture and, thus, devalue. The authors propose a simple, flexible framework for evaluating team scientists that includes both quantitative and qualitative assessments. An approach for documenting contributions of team scientists in team-based scholarship, non-traditional education, and specialized service activities is also outlined. While biostatisticians are used for illustration, the approach is generalizable to team scientists in other disciplines. PMID:25993282

  11. TATB (triaminotrinitrobenzene) purification and particle size modification: An evaluation of processing options

    SciTech Connect

    Firsich, D.W.; Thorpe, R.; Cox, L.A.

    1990-03-15

    Triaminotrinitrobenzene (TATB) is an insensitive high explosive with desirable safety characteristics. Mound is currently interested in developing a high purity, high surface area form of this compound to increase its potential applications. This paper describes recent development efforts. After setting purification and surface area goals, a number of processing procedures were tested to determine their practicality and effectiveness. The purification procedures included sulfuric acid recrystallization, dimethylsulfoxide/NaOH recrystallization, Soxhlet extraction, thermal gradient sublimation, and high-temperature recrystallization. Techniques identified for increasing surface area included crash precipitation of TATB and processing TATB in a fluid energy mill. An evaluation of the data suggested that a two- or three-step process will be necessary to produce the desired results. A sulfuric acid recrystallization used in conjunction with a high-temperature recrystallization is recommended to achieve the necessary purity. This should be followed by a crash precipitation or milling step to meet surface area requirements. 5 refs., 5 figs., 1 tab.

  12. 34 CFR 413.21 - What selection criteria does the Secretary use to evaluate an application proposing research and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... evaluate an application proposing research and development activities? 413.21 Section 413.21 Education... proposing research and development activities? The Secretary uses the following selection criteria in evaluating each research and development application: (a) Program factors. (20 points) The Secretary...

  13. 15 CFR 27.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... applications and proposals for research to be conducted or supported by a Federal Department or Agency. 27.120... § 27.120 Evaluation and disposition of applications and proposals for research to be conducted or... applications and proposals involving human subjects submitted to the department or agency through such...

  14. 7 CFR 1c.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 1c.120 Section 1c.120... disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The department or agency head will evaluate all applications and proposals involving...

  15. 28 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... applications and proposals for research to be conducted or supported by a Federal Department or Agency. 46.120....120 Evaluation and disposition of applications and proposals for research to be conducted or supported... and proposals involving human subjects submitted to the department or agency through such officers...

  16. 49 CFR 11.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 11.120 Section 11.120... disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. The department or agency head will evaluate all applications and proposals involving...

  17. 16 CFR 1028.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and proposals for research to be conducted or supported by a Federal Department or Agency. 1028.120... SUBJECTS § 1028.120 Evaluation and disposition of applications and proposals for research to be conducted... applications and proposals involving human subjects submitted to the department or agency through such...

  18. Evaluation of dredged material proposed for ocean disposal from Bronx River Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Gardiner, W.W.; Antrim, L.D.; Pinza, M.R.; Barrows, E.S.; Borde, A.B.

    1996-12-01

    The objective of the Bronx River project was to evaluate proposed dredged material from the Bronx River project area in Bronx, New York, to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Bronx River was one of five waterways that the US Army Corps of Engineers-New York District (USAGE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and to evaluate for dredging and disposal. Sediment samples were submitted for physical and chemical analyses, chemical analyses of dredging site water and elutriate, benthic and water-column acute toxicity tests, and bioaccumulation studies. Fifteen individual sediment core samples collected from the Bronx River project area were analyzed for grain size, moisture content, and total organic carbon (TOC). One composite sediment sample, representing the entire reach of the area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4- dichlorobenzene. Dredging site water and elutriate water, which was prepared from the suspended-particulate phase (SPP) of the Bronx River sediment composite, were analyzed for metals, pesticides, and PCBS.

  19. Evaluation of dredged material proposed for ocean disposal from Hudson River, New York

    SciTech Connect

    Gardiner, W.W.; Barrows, E.S.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-09-01

    The Hudson River (Federal Project No. 41) was one of seven waterways that the U.S. Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in March 1994. Sediment samples were collected from the Hudson River. Tests and analyses were conducted on Hudson River sediment core samples. The evaluation of proposed dredged material from the Hudson River included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Hudson River were analyzed for grain size, moisture content, and total organic carbon (TOC). A composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4-dichlorobenzene. Site water and elutriate water, prepared from the suspended-particulate phase (SPP) of Hudson River sediment, were analyzed for metals, pesticides, and PCBS. Water-column or SPP toxicity tests were performed with three species. Benthic acute toxicity tests were performed. Bioaccumulation tests were also conducted.

  20. Evaluating Cloud Computing in the Proposed NASA DESDynI Ground Data System

    NASA Technical Reports Server (NTRS)

    Tran, John J.; Cinquini, Luca; Mattmann, Chris A.; Zimdars, Paul A.; Cuddy, David T.; Leung, Kon S.; Kwoun, Oh-Ig; Crichton, Dan; Freeborn, Dana

    2011-01-01

    The proposed NASA Deformation, Ecosystem Structure and Dynamics of Ice (DESDynI) mission would be a first-of-breed endeavor that would fundamentally change the paradigm by which Earth Science data systems at NASA are built. DESDynI is evaluating a distributed architecture where expert science nodes around the country all engage in some form of mission processing and data archiving. This is compared to the traditional NASA Earth Science missions where the science processing is typically centralized. What's more, DESDynI is poised to profoundly increase the amount of data collection and processing well into the 5 terabyte/day and tens of thousands of job range, both of which comprise a tremendous challenge to DESDynI's proposed distributed data system architecture. In this paper, we report on a set of architectural trade studies and benchmarks meant to inform the DESDynI mission and the broader community of the impacts of these unprecedented requirements. In particular, we evaluate the benefits of cloud computing and its integration with our existing NASA ground data system software called Apache Object Oriented Data Technology (OODT). The preliminary conclusions of our study suggest that the use of the cloud and OODT together synergistically form an effective, efficient and extensible combination that could meet the challenges of NASA science missions requiring DESDynI-like data collection and processing volumes at reduced costs.

  1. Synthesis, Modification, and Characterization of Spherical SBA-15 Ordered Mesoporous Silica and Evaluation in High Performance Liquid Chromatography

    NASA Astrophysics Data System (ADS)

    Giaquinto, Alexander Paul

    SBA-15 mesoporous silica is characterized by hexagonally ordered non-intersecting parallel pores. In stark contrast, silica gel, commonly utilized in high performance liquid chromatography as a stationary phase, consists of many interconnected channels created by the spaces between primary particles. There has been much research regarding the importance of the geometry and characteristics of porous silica in chromatography, however, since the advent of ordered materials in the early 1990's, most of the investigations into use of ordered material have failed to extensively study the effects of the highly ordered porous structure on retention mechanisms. In this study, we attempt to evaluate the effect of the characteristic parallel non-intersecting pores of SBA-15 on the thermodynamics and kinetics aspects of retention. To achieve our goal, it was necessary to transform the native rope-like morphology of SBA-15 into the more commonly used and efficient sphere. The effects of temperature and synthesis time were evaluated. Following modification, characterization by low temperature nitrogen adsorption, thermogravimetric analysis and optical microscopy were utilized to evaluate pore structure, bonded layer characteristics and morphology. Suitable spherical SBA-15 packed into stainless steel columns were fully characterized for void volume and interparticle volume. Based on the results produced by kinetic studies, the evidence of column obstruction showed a reduced value for the diffusion of benzene as compared to commercial silicas, while surface specific retention studies resulted in the evaluation of reduced accessible surfaces. The obstruction of the pore volume, thus limiting the surface area, is most likely attributed to a combined effect of long narrow pores, which in the spherical particles, tend to bend or twist, and to which an uneven modified layer creates instances of pore blockage of the mobile phase.

  2. Evaluation of several modifications of an ecometric technique for assessment of media performance.

    PubMed

    Kornacki, Jeffrey L; Gurtler, Joshua B; Yan, Zhinong; Cooper, Chad M

    2003-09-01

    Recovery of Listeria monocytogenes 101M, Jonesia denitrificans, salmonellae, and Pediococcus sp. NRRL B-2354 across nine media was evaluated with three modified versions of an ecometric method. Two approaches involved the use of broth cultures (10(8) to 10(9) CFU/ml) of individual strains and either large (10-microl) or small (1-microl) presterilized plastic loops. The third approach involved precultured slants and the inoculation of media with presterilized plastic inoculating needles (10(4) CFU per needle). Absolute growth indices (AGIs) were compared. No significant differences (P < 0.05) between methods were found when tryptic soy agar supplemented with 0.6% yeast extract (TSAYE) was used for the recovery of L. monocytogenes, J. denitrificans, Pediococcus sp. NRRL B-2354, and Salmonella spp. However, the small loop-broth technique recovered significantly fewer Salmonella enterica Typhimurium DT104 and Salmonella Senftenberg 775W cells than the other two techniques did. The performance of each individual bacterial strain on each of nine media was assayed. The recovery of L. monocytogenes was excellent (AGI > 4.8) with TSAYE, PALCAM, modified Oxford medium (MOX), and Baird-Parker agar and slight with modified PRAB (AGI = 0.4) and deMan Rogosa Sharpe (MRS) agar (< 0.1), and the organism was not recovered with the remaining media (modified lysine iron agar [MLIA], xylose lysine desoxycholate [XLD] agar, and xylose lysine tergitol 4 [XLT4] agar). The recovery of J. denitrificans with TSAYE and MOX was excellent, significantly better than that achieved with PALCAM (AGI = 3.0), but the organism was not recovered with Baird-Parker agar or with the other media tested. The recovery of Pediococcus sp. NRRL B-2354 was excellent with TSAYE and modified PRAB medium > Baird-Parker agar > acidified MRS agar, but the organism was not recovered with any of the other media tested. The best recovery of S. enterica Typhimurium DT104 was achieved with TSAYE > MLIA > or = XLD agar

  3. Evaluation of Surface Modification as a Lunar Dust Mitigation Strategy for Thermal Control Surfaces

    NASA Technical Reports Server (NTRS)

    Gaier, James R.; Waters, Deborah L.; Misconin, Robert M.; Banks, Bruce A.; Crowder, Mark

    2011-01-01

    Three surface treatments were evaluated for their ability to lower the adhesion between lunar simulant dust and AZ93, AlFEP, and AgFEP thermal control surfaces under simulated lunar conditions. Samples were dusted in situ and exposed to a standardized puff of nitrogen gas. Thermal performance before dusting, after dusting, and after part of the dust was removed by the puff of gas, were compared to perform the assessment. None of the surface treatments was found to significantly affect the adhesion of lunar simulants to AZ93 thermal control paint. Oxygen ion beam texturing also did not lower the adhesion of lunar simulant dust to AlFEP or AgFEP. But a workfunction matching coating and a proprietary Ball Aerospace surface treatment were both found to significantly lower the adhesion of lunar simulants to AlFEP and AgFEP. Based on these results, it is recommended that all these two techniques be further explored as dust mitigation coatings for AlFEP and AgFEP thermal control surfaces.

  4. Evaluation and quantification of reprocessing modification in single-use devices in interventional cardiology

    NASA Astrophysics Data System (ADS)

    Tessarolo, Francesco; Ferrari, Paolo; Silvia, Bortoluzzi; Motta, Antonella; Migliaresi, Claudio; Zennaro, Lucio; Rigo, Adelio; Guarrera, Giovanni Maria; Nollo, Giandomenico

    2004-11-01

    The increasing demand in interventional cardiology urges for reprocessing of single-use-labelled medical devices. To fulfil this aim, accurate and validated regeneration protocols are mandatory to guarantee sterility, functionality and safeness. The reprocessing protocol was realized by decontamination with chloro-donors, cleaning with enzymatic solutions and hydrogen peroxide gas plasma sterilization. Reprocessing effects on ablation and electrophysiology catheters were evaluated by assessing physical-chemical changes on surfaces and bulks, as a function of the reprocessing cycles number. Conventional optical microscopy and environmental scanning electron microscopy (ESEM) underlined the presence of micro-scratches on the polyurethane shaft surface. A clear correlation was found between surface damages and number of reprocessing cycles. Atomic force microscopy (AFM) confirmed the occurrence of physical-chemical etching of the polyurethane shaft caused by the hydrogen peroxide plasma sterilization, with increasing of nano-roughness at increasing number of the reprocessing cycles. UV-Vis spectra performed on the incubation solution of polymeric shaft sample, showed an absorbance increase at about 208 nm. This fact could be attributed to the water elution from the polymer of low molecular weight oligomers. The presence of hydrolysis products of the polymeric shaft after incubation demands both the characterization of the products released in the solution and the chemical characterization of the water exposed surface.

  5. Modifications of in vitro skin penetration under solar irradiation: evaluation on flow-through diffusion cells.

    PubMed

    Gélis, Christelle; Mavon, Alain; Delverdier, Maxence; Paillous, Nicole; Vicendo, Patricia

    2002-06-01

    The effect of solar irradiation on ex vivo dermatomed hairless rat skin samples maintained in culture on flow-through diffusion cells for at least 24 h was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and by histological observations. Transepidermal water loss (TEWL) measurements and kinetic analysis of the permeation of both tritiated water and 14C caffeine through the skin were performed after full-spectrum solar exposure involving the use of a xenon arc solar simulator. After a UV exposure of less than 420 mJ/cm2, skin integrity and permeation of both water and caffeine did not change significantly. In contrast, after a 420 mJ/cm2 UV exposure, the epidermis appeared more contracted, associated with an increase of 55% of TEWL and 220% of the skin permeation of tritiated water after 6 h. The data suggested a dramatic alteration of the skin barrier integrity. Moreover, the flux of 14C caffeine increased rapidly by 338% of the absorption of water 12 h after irradiation. These results reveal the presence of a threshold UV exposure that would not modify skin penetration.

  6. Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation.

    PubMed

    Suksamrarn, Apichart; Ponglikitmongkol, Mathurose; Wongkrajang, Kanjana; Chindaduang, Anon; Kittidanairak, Suthadta; Jankam, Aroon; Yingyongnarongkul, Boon-ek; Kittipanumat, Narin; Chokchaisiri, Ratchanaporn; Khetkam, Pichit; Piyachaturawat, Pawinee

    2008-07-15

    Three new diarylheptanoids, a 1:2 mixture of (3S)- and (3R)-1-(4-methoxyphenyl)-7-phenyl-(6E)-6-hepten-3-ol (13a and 13b) and 1-(4-hydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-one (15), together with two synthetically known diarylheptanoids 1,7-diphenyl-(1E,3E,5E)-1,3,5-triene (9) and 1-(4-hydroxyphenyl)-7-phenyl-(4E,6E)-4,6-heptadien-3-one (16), and nine known diarylheptanoids, 2, 8, 10-12, 14, a 3:1 mixture of 17a and 17b, and 18, were isolated from the rhizomes of Curcuma comosa Roxb. The absolute stereochemistry of the isolated compounds has also been determined using the modified Mosher's method. The isolated compounds and the chemically modified analogues were evaluated for their estrogenic-like transcriptional activity using RT-PCR in HeLa cell line. Some of the isolated diarylheptanoids and their modified analogues exhibited estrogenic activity comparable to or higher than that of the phytoestrogen genistein. Based on the transcriptional activation of both estrogenic targets, Bcl-xL and ERbeta gene expression, the structural features for a diarylheptanoid to exhibit high estrogenic activity are the presence of an olefinic function conjugated with the aromatic ring at the 7-position, a keto group at the 3-position, and a phenolic hydroxyl group at the p-position of the aromatic ring attached to the 1-position of the heptyl chain.

  7. [Empirical standard costs for health economic evaluation in Germany -- a proposal by the working group methods in health economic evaluation].

    PubMed

    Krauth, C; Hessel, F; Hansmeier, T; Wasem, J; Seitz, R; Schweikert, B

    2005-10-01

    Measurement of health care costs is a crucial task in health economic evaluation. Various guidelines with different amount of details have been set up for costing methods in economic evaluation which, however, do not precisely stipulate how to value resource consumption. In this article we present a proposal for the standardisation of the monetary valuation of health care utilisation occurring in the follow up period after the actual intervention to be evaluated. From a societal perspective the primary direct and indirect cost components are considered, such as outpatient medical care, pharmaceuticals, non-physician health services, inpatient care, days of sick leave and early retirement due to sickness. The standard costs are based on administrative charges and rates or on official statistics. They are based on the most current data sources which are mainly from 2002 and 2003. This system of standard costs aims at an average valuation of resource consumption. This makes for the comparability of different health economic studies. Most standard costs are not based on market prices but on administratively specified charges and rates. This implies that institutional changes which are quite common in the health care system, may also affect the valuation rates, for example the introduction of DRGs. This should be taken into account when updating the system of standard costs.

  8. ARSENIC REMOVAL FROM DRINKING WATER BY PROCESS MODIFICATION TO COAGULATION/FILTRATION. USEPA DEMONSTRATION PROJECT AT LIDGERWOOD, ND. FINAL PERFORMANCE EVALUATION REPORT

    EPA Science Inventory

    This report documents the activities performed and the results obtained for the arsenic removal treatment technology demonstration project at the Lidgerwood, North Dakota site. The objectives of the project were to evaluate: (1) the effectiveness of process modifications to an e...

  9. Supplemental Environmental Baseline Survey for Proposed Land Use Permit Modification for Expansion of the Dynamic Explosive Test Site (DETS) 9940 Main Complex Parking Lot

    SciTech Connect

    Peek, Dennis W.

    2016-10-01

    The “subject property” is comprised of a parcel of land within the Kirtland Military Reservation, Bernalillo County, New Mexico, as shown on the map in Appendix B of this document. The land requirement for the parking lot addition to the 9940 Main Complex is approximately 2.7 acres. The scope of this Supplemental Environmental Baseline Survey (SEBS) is for the parking lot addition land transfer only. For details on the original 9940 Main Complex see Environmental Baseline Survey, Land Use Permit Request for the 9940 Complex PERM/0-KI-00-0001, August 21, 2003, and for details on the 9940 Complex Expansion see Environmental Baseline Survey, Proposed Land Use Permit Expansion for 9940 DETS Complex, June 24, 2009. The 2.7-acre parcel of land for the new parking lot, which is the subject of this EBS (also referred to as the “subject property”), is adjacent to the southwest boundary of the original 12.3- acre 9940 Main Complex. No testing is known to have taken place on the subject property site. The only activity known to have taken place was the burial of overhead utility lines in 2014. Adjacent to the subject property, the 9940 Main Complex was originally a 12.3-acre site used by the Department of Energy (DOE) under a land use permit from the United States Air Force (USAF). Historical use of the site, dating from 1964, included arming, fusing, and firing of explosives and testing of explosives systems components. In the late 1970s and early 1980s experiments at the 9940 Main Complex shifted toward reactor safety issues. From 1983 to 1988, fuel coolant interaction (FCI) experiments were conducted, as were experiments with conventional high explosives (HE). Today, the land is used for training of the Nuclear Emergency Response community and for research on energetic materials. In 2009, the original complex was expanded to include four additional 20-acre areas: 9940 Training South, 9940 Training East, T-Range 6, and Training West Landing Zone. The proposed use of

  10. Visual privacy by context: proposal and evaluation of a level-based visualisation scheme.

    PubMed

    Padilla-López, José Ramón; Chaaraoui, Alexandros Andre; Gu, Feng; Flórez-Revuelta, Francisco

    2015-06-04

    Privacy in image and video data has become an important subject since cameras are being installed in an increasing number of public and private spaces. Specifically, in assisted living, intelligent monitoring based on computer vision can allow one to provide risk detection and support services that increase people's autonomy at home. In the present work, a level-based visualisation scheme is proposed to provide visual privacy when human intervention is necessary, such as at telerehabilitation and safety assessment applications. Visualisation levels are dynamically selected based on the previously modelled context. In this way, different levels of protection can be provided, maintaining the necessary intelligibility required for the applications. Furthermore, a case study of a living room, where a top-view camera is installed, is presented. Finally, the performed survey-based evaluation indicates the degree of protection provided by the different visualisation models, as well as the personal privacy preferences and valuations of the users.

  11. Proposal for a trigonometric method to evaluate the abduction angle of the lower limbs in neonates.

    PubMed

    Lima, Thaís; Alves, Cyntia; Funayama, Carolina A R

    2008-12-01

    It is difficult to precisely measure articular arc movement in newborns using a goniometer. This article proposes an objective method based on trigonometry for the evaluation of lower limb abduction. With the newborn aligned in the dorsal decubitus position, 2 points are marked at the level of the medial malleolus, one on the sagittal line and the other at the end of the abduction. Using the right-sided line between these 2 points and a line from the medial malleolus to the reference point at the anterior superior iliac spine or umbilical scar, an isosceles triangle is drawn, and half of the inferential abduction angle is obtained by calculating the sine. Twenty healthy full-term newborns comprise the study cohort. Intersubject and intrasubject variability among the abduction angle values (mean [SD], 37 degrees [4] degrees) is low. This method is advantageous because the measurement is precise and because the sine can be used without approximation.

  12. Visual Privacy by Context: Proposal and Evaluation of a Level-Based Visualisation Scheme

    PubMed Central

    Padilla-López, José Ramón; Chaaraoui, Alexandros Andre; Gu, Feng; Flórez-Revuelta, Francisco

    2015-01-01

    Privacy in image and video data has become an important subject since cameras are being installed in an increasing number of public and private spaces. Specifically, in assisted living, intelligent monitoring based on computer vision can allow one to provide risk detection and support services that increase people's autonomy at home. In the present work, a level-based visualisation scheme is proposed to provide visual privacy when human intervention is necessary, such as at telerehabilitation and safety assessment applications. Visualisation levels are dynamically selected based on the previously modelled context. In this way, different levels of protection can be provided, maintaining the necessary intelligibility required for the applications. Furthermore, a case study of a living room, where a top-view camera is installed, is presented. Finally, the performed survey-based evaluation indicates the degree of protection provided by the different visualisation models, as well as the personal privacy preferences and valuations of the users. PMID:26053746

  13. Mortality differentials by lifetime earnings decile: implications for evaluations of proposed Social Security law changes.

    PubMed

    Waldron, Hilary

    2013-01-01

    To evaluate the distributional effects of some proposed Social Security law changes, such as an increase in Social Security's early entitlement age, retirement policy analysts typically tabulate the number of workers who fall below a predetermined threshold of hardship. Analysts using this technique often implicitly assume that the insured population falls neatly into a low-earnings poor health group and a remaining good health group. If the hardship threshold assumption is correct, there should be no difference in mortality risk between lifetime earnings deciles above a hardship threshold. This study finds that the hardship threshold model is overwhelmingly rejected in US Social Security data, a result consistent with similar studies conducted in Canada, Germany, and England. The bottom 80-95 percent of the male lifetime earnings distribution exhibits an inverse correlation with regard to mortality risk (the higher the earnings, the lower the mortality risk) at ages 63-71.

  14. A proposal to evaluate mechanistic efficacy of hallucinogens in addiction treatment.

    PubMed

    Burdick, Brittany Vasae; Adinoff, Bryon

    2013-09-01

    Current treatments for addiction are frequently ineffective. Hallucinogenic therapy has been indicated as helpful for a range of substance use disorders, yet this approach remains understudied and publicly unavailable. It is nonetheless a promising treatment, which has significant, long-term beneficial effects with single doses and a profile characterized by general safety, low toxicity, and non-addictiveness. However, pharmacological interventions, such as hallucinogens, should not be offered if the same effects (e.g. psychological insights/mystical experiences) and outcomes (e.g. decreased drug use) could be achieved absent pharmacological intervention. To date, there have been no clinical comparisons of drug-induced altered states with non-drug-induced states for addiction treatment. We propose and then outline a clinical trial to address this gap in knowledge. The proposed design would evaluate abstinence outcomes in a population of prescription opioid abusers after exposure to one of three conditions: a drug-induced altered state using psilocybin, a non-drug-induced altered state via hyperventilation (Holotropic Breathwork), and an active placebo with niacin. The outcomes of such a study would reveal important differences in therapeutic potential by discriminating hallucinogen-dependent effects from those psychological effects resulting from altered states.

  15. Outcome Evaluation of a Policy-Mandated Lifestyle and Environmental Modification Program in a National Job Training Center.

    PubMed

    Jimenez, Elizabeth Yakes; Harris, Amanda; Luna, Donald; Velasquez, Daniel; Slovik, Jonathan; Kong, Alberta

    2016-10-18

    Excess weight gain is common when adolescents become young adults, but there are no obesity prevention or weight management interventions that have been tested for emerging adults who follow non-traditional post-secondary paths, such as enrolling in job training programs. We evaluated Healthy Eating & Active Lifestyles (HEALs), a policy-mandated lifestyle education/environmental modification program, at a job training center for low-income 16-24 year olds. We examined average change in body mass index (BMI) z-score from baseline to 6 months for emerging adults (aged 16-24 years) in pre-HEALs implementation (n = 125) and post-HEALs implementation (n = 126) cohorts living at the job training center, by baseline weight status. In both cohorts, average BMI z-score significantly increased from baseline to 6 months for students with BMI < 25. Average BMI z-score significantly decreased for the overweight (BMI 25 to <30; -0.11, p = .03) and obese (BMI ≥ 30; -0.11, p = .001) students only within the post-HEALs cohort; changes within the pre-HEALs cohort and between cohorts were not significant. HEALs may promote positive weight-related trends for overweight/obese students, but prevention efforts for non-overweight/obese students need to be improved.

  16. Surface modification of PdlLGA microspheres with gelatine methacrylate: Evaluation of adsorption, entrapment, and oxygen plasma treatment approaches.

    PubMed

    Baki, Abdulrahman; Rahman, Cheryl V; White, Lisa J; Scurr, David J; Qutachi, Omar; Shakesheff, Kevin M

    2017-01-16

    Injectable poly (dl-lactic-co-glycolic acid) (PdlLGA) microspheres are promising candidates as biodegradable controlled release carriers for drug and cell delivery applications; however, they have limited functional groups on the surface to enable dense grafting of tissue specific biocompatible molecules. In this study we have evaluated surface adsorption, entrapment and oxygen plasma treatment as three approaches to modify the surfaces of PdlLGA microspheres with gelatine methacrylate (gel-MA) as a biocompatible and photo cross-linkable macromolecule. Time of flight secondary ion mass spectroscopy (TOF SIMS) and X-ray photoelectron spectroscopy (XPS) were used to detect and quantify gel-MA on the surfaces. Fluorescent and scanning electron microscopies (SEM) were used to image the topographical changes. Human mesenchymal stem cells (hMSCs) of immortalised cell line were cultured on the surface of gel-MA modified PdlLGA microspheres and Presto-Blue assay was used to study the effect of different surface modifications on cell proliferation. Data analysis showed that the oxygen plasma treatment approach resulted in the highest density of gel-MA deposition. This study supports oxygen plasma treatment as a facile approach to modify the surface of injectable PdlLGA microspheres with macromolecules such as gel-MA to enhance proliferation rate of injected cells and potentially enable further grafting of tissue specific molecules.

  17. Proposal of a Nutritional Quality Index (NQI) to Evaluate the Nutritional Supplementation of Sportspeople

    PubMed Central

    Palacin-Arce, Alba; Monteagudo, Celia; Beas-Jimenez, Juan de Dios; Olea-Serrano, Fatima; Mariscal-Arcas, Miguel

    2015-01-01

    Background Numerous supplements are used by sportspeople. They are not always appropriate for the individual or the sports activity and may do more harm than good. Vitamin and mineral supplements are unnecessary if the energy intake is sufficient to maintain body weight and derives from a diet with an adequate variety of foods. The study objectives were to evaluate the main nutrients used as supplements in sports and to propose a nutritional quality index (NQI) that enables sportspeople to optimize their use of supplements and detect and remedy possible nutritional deficits. Material and Methods A nutritional study was performed in 485 sportspeople recruited from Centros Andaluces de Medicina del Deporte, (CAMD). All completed socio-demographic, food frequency, and lifestyle questionnaires. The nutritional quality of their diet and need for supplementation were evaluated by scoring their dietary intake with and without supplementation, yielding two NQI scores (scales of 0-21 points) for each participant. Results A superior mean NQI score was obtained when the supplements taken by participants were not included (16. 28 (SD of 3.52)) than when they were included (15.47 (SD: 3.08)), attributable to an excessive intake of some nutrients through supplementation. Conclusions These results indicate that sportspeople with a varied and balanced diet do not need supplements, which appear to offer no performance benefits and may pose a health risk. PMID:25938239

  18. Pre-participation gynecological evaluation of female athletes: a new proposal

    PubMed Central

    Parmigiano, Tathiana Rebizzi; Zucchi, Eliana Viana Monteiro; de Araujo, Maíta Poli; Guindalini, Camila Santa Cruz; Castro, Rodrigo de Aquino; Bella, Zsuzsanna Ilona Katalin de Jármy Di; Girão, Manoel João Batista Castello; Cohen, Moisés; Sartori, Marair Gracio Ferreira

    2014-01-01

    Objective To propose the inclusion of a gynecological investigation during the evaluation of athletes before competitions, using a specific instrument called the Pre-participation Gynecological Examination (PPGE). Methods The study assessed 148 athletes, mean age of 15.4±2.0 years, who engaged in eight different sports modalities, and who responded to a questionnaire named Pre-Participation Gynecological Examination (PPGE), to the International Consultation on Incontinence Questionnaire - Short Form (for urinary loss), and to the Eating Attitudes Test (for eating disorders). Results Fifty percent of the participants reported irregular menstrual intervals, 23.0% did not know about sexually transmitted diseases, and 72.4% denied having, at least, an annual gynecological appointment. The study identified 18.2% who had urinary loss, and 15% presented with an increased risk of eating disorders. Moreover, 89.9% were not familiar with the occurrence of urinary incontinence in athletes and did not know that they were susceptible to the female athlete triad. A total of 87.1% of them stated that would not mention these issues to their coaches even if this would improve their health or performance. Conclusion The Pre-Participation Gynecological Examination can be considered an easy-to-apply instrument that allowed the diagnosis of alterations often underestimated by the athletes themselves. After its application, the alterations were identified, and determined the athletes’ referral to appropriate evaluation and treatment. PMID:25628197

  19. Parent and family impact of autism spectrum disorders: a review and proposed model for intervention evaluation.

    PubMed

    Karst, Jeffrey S; Van Hecke, Amy Vaughan

    2012-09-01

    Raising a child with an autism spectrum disorder (ASD) can be an overwhelming experience for parents and families. The pervasive and severe deficits often present in children with ASD are associated with a plethora of difficulties in caregivers, including decreased parenting efficacy, increased parenting stress, and an increase in mental and physical health problems compared with parents of both typically developing children and children with other developmental disorders. In addition to significant financial strain and time pressures, high rates of divorce and lower overall family well-being highlight the burden that having a child with an ASD can place on families. These parent and family effects reciprocally and negatively impact the diagnosed child and can even serve to diminish the positive effects of intervention. However, most interventions for ASD are evaluated only in terms of child outcomes, ignoring parent and family factors that may have an influence on both the immediate and long-term effects of therapy. It cannot be assumed that even significant improvements in the diagnosed child will ameliorate the parent and family distress already present, especially as the time and expense of intervention can add further family disruption. Thus, a new model of intervention evaluation is proposed, which incorporates these factors and better captures the transactional nature of these relationships.

  20. Evaluation of materials proposed for the construction of the Plasma Electrode Pockels Cell (PEPC) on beamlet

    NASA Astrophysics Data System (ADS)

    Roberts, D.; Robb, C.; Deyoreo, J.; Atherton, J.

    1992-11-01

    The proposed upgrade of the NOVA laser system at Lawrence Livermore National Laboratory employs a multipass architecture that requires an optical switch to emit the laser light at the appropriate fluence. This Pockels cell-based optical switch does not use traditional ring or thin-film electrodes because of the large aperture and high fluence of the laser system. Rather, it uses a plasma electrode Pockels cell with a KD*P crystal as the electro-optical medium. A discharge plasma is formed on each side of the electro-optic crystal and high voltage is applied across the crystal through the plasma electrode to initiate optical switching. In October 1991 we began evaluating materials suggested for the large aperture plasma electrode optical switch. Previous experiments suggested that switching performance could be significantly affected by the deterioration of cell materials. The final prototype switch tested used polyethylene for the switch body, Mykroy for the mid-plane and a silicone vulcanite to encapsulate the KD*P crystal. The encapsulant easily compensated for the effect of assembling the optical switch and no strain-induced birefringence in the crystal after encapsulation was measured. Oxygen was eventually added to the plasma to react with the sputtered carbon from the cathode and produce a gaseous effluent. As an added benefit, the production of ozone absorbed most of the ultraviolet radiation affecting the encapsulant. All the materials tested decomposed and produced volatiles, although no change in the damage threshold of exposed optical surfaces tested to date was seen. An evaluation of the recommended materials for major cell components using published manufacturers data, experimental results from our Material Evaluation Apparatus, and outgassing performance and sputtering data produced at the Laboratory's Vacuum Process Lab is presented.

  1. Tier 1 ecological evaluation of proposed discharge of dredged material from Oakland Harbor into ocean waters

    SciTech Connect

    Shreffler, D.K.; Thorn, R.M.; Walls, B.E.; Word, J.Q.

    1994-01-01

    The Water Resources Development Act of 1986 (Public Law 99--662) authorized the U.S. Army Corps of Engineers (USACE) -- San Francisco District, to accommodate larger, deeper draft vessels in Oakland inner and Outer Harbors by deepening and widening the existing navigation channel, and providing turning basins and maneuvering areas in Oakland inner Harbor. The suitability of the resulting dredged material for disposal into ocean waters was subject to the procedures of the 1991 Testing Manual, Evaluation of Dredged Material Proposed for Ocean Disposal, known as the ``Green Book``. The Green Book provides a tiered approach for testing the suitability of dredged materials through chemical, physical, and biological evaluations. The first level of investigation, or Tier 1 evaluation, is used to determine whether a decision on LPC compliance can be made on the basis of readily available information. The Tier 1 report primarily summarizes existing information on sediment contamination and toxicity potential, identifies contaminants of concern, and determines the need for further testing. To assist the USACE in determining the suitability of dredged material from Oakland inner and Outer Harbors for ocean disposal, Battelle/Marine Sciences Laboratory prepared this Tier 1 report based upon information and data provided by USACE. Because this Tier 1 report originated well after an LPC determination was made to require testing of project sediments in Tier 3, the primary purpose of this report was to identify contaminants of concern (if any) in that particular dredged material. In addition, this Tier 1 report summarizes available information on chemical, physical, and biological characterization of the sediments in Oakland inner and Outer Harbors.

  2. Notification: Preliminary Research to Evaluate Proposed Superfund Sites on the U.S. EPA's National Priorities List

    EPA Pesticide Factsheets

    Project #OPE-FY13-0018, April 4, 2013. The Office of Inspector General plans to begin preliminary research to evaluate proposed Superfund sites on the U.S. Environmental Protection Agency’s National Priorities List.

  3. 40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.120 Evaluation and disposition of applications and proposals for research to be conducted or supported... applications and proposals for research to be conducted or supported by a Federal Department or Agency....

  4. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section...

  5. 45 CFR 690.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... proposals for research to be conducted or supported by a Federal department or agency. 690.120 Section 690.120 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.120 Evaluation and disposition of applications and proposals for...

  6. 32 CFR 219.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 219.120 Section 219...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The department...

  7. 10 CFR 745.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... applications and proposals for research to be conducted or supported by a Federal department or agency. The... 10 Energy 4 2010-01-01 2010-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal department or agency. 745.120 Section...

  8. 23 CFR 636.303 - May pre-qualification standards be used as proposal evaluation criteria in the RFP?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false May pre-qualification standards be used as proposal evaluation criteria in the RFP? 636.303 Section 636.303 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal...

  9. 23 CFR 636.303 - May pre-qualification standards be used as proposal evaluation criteria in the RFP?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false May pre-qualification standards be used as proposal evaluation criteria in the RFP? 636.303 Section 636.303 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal...

  10. Proposed Facility Modifications to Support Propulsion Systems Testing Under Simulated Space Conditions at Plum Brook Station's Spacecraft Propulsion Research Facility (B-2)

    NASA Technical Reports Server (NTRS)

    Edwards, Daryl A.

    2008-01-01

    Preparing NASA's Plum Brook Station's Spacecraft Propulsion Research Facility (B-2) to support NASA's new generation of launch vehicles has raised many challenges for B-2's support staff. The facility provides a unique capability to test chemical propulsion systems/vehicles while simulating space thermal and vacuum environments. Designed and constructed in the early 1960s to support upper stage cryogenic engine/vehicle system development, the Plum Brook Station B-2 facility will require modifications to support the larger, more powerful, and more advanced engine systems for the next generation of vehicles leaving earth's orbit. Engine design improvements over the years have included large area expansion ratio nozzles, greater combustion chamber pressures, and advanced materials. Consequently, it has become necessary to determine what facility changes are required and how the facility can be adapted to support varying customers and their specific test needs. Exhaust system performance, including understanding the present facility capabilities, is the primary focus of this work. A variety of approaches and analytical tools are being employed to gain this understanding. This presentation discusses some of the challenges in applying these tools to this project and expected facility configuration to support the varying customer needs.

  11. Proposed Facility Modifications to Support Propulsion Systems Testing Under Simulated Space Conditions at Plum Brook Station's Spacecraft Propulsion Research Facility (B-2)

    NASA Technical Reports Server (NTRS)

    Edwards, Daryl A.

    2007-01-01

    Preparing NASA's Plum Brook Station's Spacecraft Propulsion Research Facility (B-2) to support NASA's new generation of launch vehicles has raised many challenges for B-2 s support staff. The facility provides a unique capability to test chemical propulsion systems/vehicles while simulating space thermal and vacuum environments. Designed and constructed 4 decades ago to support upper stage cryogenic engine/vehicle system development, the Plum Brook Station B-2 facility will require modifications to support the larger, more powerful, and more advanced engine systems for the next generation of vehicles leaving earth's orbit. Engine design improvements over the years have included large area expansion ratio nozzles, greater combustion chamber pressures, and advanced materials. Consequently, it has become necessary to determine what facility changes are required and how the facility can be adapted to support varying customers and their specific test needs. Instrumental in this task is understanding the present facility capabilities and identifying what reasonable changes can be implemented. A variety of approaches and analytical tools are being employed to gain this understanding. This paper discusses some of the challenges in applying these tools to this project and expected facility configuration to support the varying customer needs.

  12. The Cotingo Dam as a Test of Brazil's System for Evaluating Proposed Developments in Amazonia

    PubMed

    Fearnside; Barbosa

    1996-09-01

    The proposed Cotingo Dam in Brazil's far northern state of Roraima is examined with the objective of drawing lessons for Brazil's system of evaluating environmental, social, and financial consequences of development decisions. The Cotingo Dam illustrates the difficulty of translating into practice the principles of economic and environmental assessment. Examination of the financial arguments for the Cotingo Dam indicates that justifications in this sphere are insufficient to explain why the project is favored over other alternatives and points to political factors as the best explanation of the project's high priority. Strong pressure from political and entrepreneurial interest groups almost invariably dominates decision making in Amazonia. The analysis indicates the inherent tendency of the present system to produce decisions in favor of large construction projects at the expense of the environment and local peoples. The requirements intended to assure proper weight for these concerns, such as the report on environmental impacts (RIMA) and the public hearing, fail to serve this role. Cotingo also provides a test case for constitutional protections restricting construction of dams in indigenous lands.KEY WORDS: Hydroelectric dams; Amazonia; Indigenous peoples; Brazil; Roraima

  13. Behavior modification.

    PubMed

    Pelham, W E; Fabiano, G A

    2000-07-01

    Attention deficit/hyperactivity disorder (ADHD) is a chronic and substantially impairing disorder. This means that treatment must also be chronic and substantial. Behavior Modification, and in many cases, the combination of behavior modification and stimulant medication, is a valid, useful treatment for reducing the pervasive impairment experienced by children with ADHD. Based on the research evidence reviewed, behavior modification should be the first line of treatment for children with ADHD.

  14. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... proposal under the applicable selection factor and in comparison to the other proposals received, if any... selection factors may not exceed a total of three. (b) The Director will then assign a cumulative...

  15. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... proposal under the applicable selection factor and in comparison to the other proposals received, if any... selection factors may not exceed a total of three. (b) The Director will then assign a cumulative...

  16. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... proposal under the applicable selection factor and in comparison to the other proposals received, if any... selection factors may not exceed a total of three. (b) The Director will then assign a cumulative...

  17. 78 FR 44579 - 30-Day Notice of Proposed Information Collection: Fellowship Placement Pilot Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... URBAN DEVELOPMENT 30-Day Notice of Proposed Information Collection: Fellowship Placement Pilot Program.... A. Overview of Information Collection Title of Information Collection: Fellowship Placement Pilot.... Description of the need for the information and proposed use: The Fellowship Placement Program places...

  18. 78 FR 9448 - 60-Day Notice of Proposed Information Collection: Young Turkey/Young America Evaluation (YTYA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE 60-Day Notice of Proposed Information Collection: Young Turkey/ Young America Evaluation (YTYA) Survey ACTION... Information Collection: Young Turkey/Young America Evaluation (YTYA) Survey. OMB Control Number: None. Type...

  19. 78 FR 31999 - 30-Day Notice of Proposed Information Collection: Young Turkey/Young America Evaluation (YTYA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE 30-Day Notice of Proposed Information Collection: Young Turkey/ Young America Evaluation (YTYA) Survey ACTION... Collection: Young Turkey/Young America Evaluation (YTYA) Survey. OMB Control Number: None. Type of...

  20. STEMs: A Proposal for Calibrated Classroom Assessments That Increase Student Motivation and Provide Authentic Evaluation of Student Learning

    ERIC Educational Resources Information Center

    Murrieta, Hector; Amerson, Gordon

    2011-01-01

    The purpose of this study was to validate the development and proposal of what the authors call STEMs (Standards Tests to Evaluate Mastery) and have defined them as calibrated classroom assessments that increase student motivation and provide authentic evaluation of student learning. Theoretical and empirical research on classroom assessment and…

  1. The modification and evaluation of an ELISA test for the surveillance of Mycobacterium avium subsp. paratuberculosis infection in wild ruminants

    PubMed Central

    2013-01-01

    developed. In order to generate reliable test results, it is essential to evaluate the test and perform modifications if deemed necessary. Despite the challenges inherent to wildlife diagnostics, we have shown that several methods can be used to improve confidence in test results. PMID:23302439

  2. 48 CFR 801.602-83 - Documents to submit for legal or technical review-contract modifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... (4) A statement analyzing what necessitated the modification (e.g., a design error, technical changes... COTR's independent cost evaluation. (iii) The architect/engineer's independent cost evaluation, if... as negotiation criteria. (c) For a proposed modification to an architect/engineer contract,...

  3. Evaluation of a Proposed Biodegradable 188Re Source for Brachytherapy Application

    PubMed Central

    Khorshidi, Abdollah; Ahmadinejad, Marjan; Hamed Hosseini, S.

    2015-01-01

    Abstract This study aimed to evaluate dosimetric characteristics based on Monte Carlo (MC) simulations for a proposed beta emitter bioglass 188Re seed for internal radiotherapy applications. The bioactive glass seed has been developed using the sol-gel technique. The simulations were performed for the seed using MC radiation transport code to investigate the dosimetric factors recommended by the AAPM Task Group 60 (TG-60). Dose distributions due to the beta and photon radiation were predicted at different radial distances surrounding the source. The dose rate in water at the reference point was calculated to be 7.43 ± 0.5 cGy/h/μCi. The dosimetric factors consisting of the reference point dose rate, D(r0,θ0), the radial dose function, g(r), the 2-dimensional anisotropy function, F(r,θ), the 1-dimensional anisotropy function, φan(r), and the R90 quantity were estimated and compared with several available beta-emitting sources. The element 188Re incorporated in bioactive glasses produced by the sol-gel technique provides a suitable solution for producing new materials for seed implants applied to brachytherapy applications in prostate and liver cancers treatment. Dose distribution of 188Re seed was greater isotropic than other commercially attainable encapsulated seeds, since it has no end weld to attenuate radiation. The beta radiation-emitting 188Re source provides high doses of local radiation to the tumor tissue and the short range of the beta particles limit damage to the adjacent normal tissue. PMID:26181543

  4. Evaluation of a proposed molecular methodology for the serotyping of Avibacterium paragallinarum.

    PubMed

    Wang, Hongjun; Sun, Huiling; Blackall, Patrick J; Zhang, Zhenhua; Zhou, Hongzhuan; Xu, Fuzhou; Chen, Xiaoling

    2016-09-01

    A multiplex (m)PCR and a PCR followed by restriction fragment length polymorphism (RFLP) analysis of Avibacterium paragallinarum have been proposed as alternatives to conventional serotyping by the Page scheme. We evaluated both methods, and also sequenced the PCR-RFLP target fragment to reexamine the capacity of molecular serotyping. Eleven reference strains and 27 field isolates were used. Many reference strains and isolates were misidentified as Page serogroup B. The sequence analysis revealed 6 profiles based on the matching rates of the target sequence with the 3 reverse primers of the mPCR. The reference strains and field isolates in profiles 1 and 4 were correctly identified as serogroup A or C by the mPCR. The strains and/or isolates in profiles 2, 3, 5, and 6 could be misidentified as serogroup B or as nontypeable by the mPCR. The homology comparison of the sequences showed that the target sequence of the mPCR, called region 2, was not Page serogroup specific, although some Kume serovars, such as A-1 and C-2, were correctly serotyped. In addition, there was a 9 nucleotide deletion in the sequences of profiles 1, 3, and 5, but not of profiles 2, 4, and 6. Overall, we confirmed that the mPCR and PCR-RFLP molecular assays are not suitable for identifying the serogroups of A. paragallinarum isolates. With further study, analysis of region 2 sequences may have potential as a means of recognizing the Kume serovars of A. paragallinarum isolates.

  5. 48 CFR 215.203-70 - Requests for proposals-tiered evaluation of offers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 215.203-70 Requests for...

  6. Environmental Baseline Survey for Proposed Land Use Permit Modification for Expansion of the Dynamic Explosive Test Site (DETS) 9940 Main Complex Parking Lot.

    SciTech Connect

    Peek, Dennis W.

    2016-02-01

    The approach was to perform a document search, supplemented by a visual site inspection, to identify potential environmental contamination associated with the property. Factors evaluated included hazardous substances; petroleum products and derivatives; environmental restoration sites; areas of concern; storage tanks; oil/water separators; grease traps; wash racks; waste tanks; pesticides; military munitions/ordnance; medical or bio-hazardous waste; radioactive waste; solid/municipal waste; indoor air quality; groundwater; wastewater treatment, collection, and disposal/discharge; drinking water quality; utilities; asbestos; polychlorinated biphenyls (PCBs); radon; lead-based paint; cultural resources; floodplains; and natural/biological resources.

  7. 77 FR 30050 - VASRD Status Summit: A Public Overview of Proposed Disability Evaluation Criteria

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... following nine body systems: (1) The Hemic and Lymphatic Systems (38 CFR 4.117), (2) The Endocrine System... Summit is to capture public comments on working drafts of proposed regulations for nine body ] systems... their input, prior to the drafting of proposed regulations for the body systems. VA plans to...

  8. 76 FR 15281 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... Request--Evaluation of the Quantity and Quality of Nutritional Information Available to School Food... new collection for evaluation of the quantity and quality of nutritional information available to...: Evaluation of the Quantity and Quality of Nutritional Information Available to School Food Authorities...

  9. Experimental evaluation of two turning vane designs for high-speed corner of 0.1-scale model of NASA Lewis Research Center's proposed altitude wind tunnel

    NASA Technical Reports Server (NTRS)

    Moore, R. D.; Boldman, D. R.; Shyne, R. J.

    1986-01-01

    Two turning vane designs were experimentally evaluated for corner 1 (downstream of the test section) of a 0.1-scale model of the NASA Lewis Research Center's proposed Altitude Wind Tunnel (AWT). Vane A was a controlled-diffusion airfoil shape; vane B was a circular-arc airfoil shape. The vane designs were tested over corner inlet Mach numbers from 0.16 to 0.465. Several modifications in vane setting angle and vane spacing were also evaluated for vane A. The overall performance obtained from total pressure rakes indicated that vane B had a slightly lower loss coefficient than vane A. At Mach 0.35 (the design Mach number without the engine exhaust removal scoop), the loss coefficients were 0.150 and 0.178 for vanes B and A, respectively. Resetting the vane A angle by -5 deg. (vane A10) to turn the flow toward the outside corner reduced the loss coefficient to 0.119. The best configuration (vane A10) was also tested with a simulated engine exhaust removal scoop. The loss coefficient for that configuration was 0.164 at Mach 0.41 (the approximate design Mach number with the scoop).

  10. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... commodity to the project. Applications that demonstrate high likelihood of success in these areas will... Medium-sized farm or ranch that is structured as a Family Farm, Mid Tier Value Chain proposals,...

  11. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... commodity to the project. Applications that demonstrate high likelihood of success in these areas will... Medium-sized farm or ranch that is structured as a Family Farm, Mid Tier Value Chain proposals,...

  12. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... commodity to the project. Applications that demonstrate high likelihood of success in these areas will... Medium-sized farm or ranch that is structured as a Family Farm, Mid Tier Value Chain proposals,...

  13. 78 FR 10593 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... Food and Nutrition Service Agency Information Collection Activities: Proposed Collection; Comment...) Direct Certification of Children Receiving Medicaid Benefits AGENCY: Food and Nutrition Service (FNS... collection techniques or other forms of information technology. Comments may be sent to: Steve Carlson,...

  14. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... finds an institution has materially failed to comply with the terms of this policy. (b) In making decisions about supporting or approving applications or proposals covered by this policy the department...

  15. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... finds an institution has materially failed to comply with the terms of this policy. (b) In making decisions about supporting or approving applications or proposals covered by this policy the department...

  16. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt... proposals shall be performed only by employees of the Department of Energy. As used in this...

  17. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt... proposals shall be performed only by employees of the Department of Energy. As used in this...

  18. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt... proposals shall be performed only by employees of the Department of Energy. As used in this...

  19. [Hospital food: proposals for qualification of the Food and Nutrition Service, evaluated by the scientific community].

    PubMed

    Diez-Garcia, Rosa Wanda; Padilha, Marina; Sanches, Maísa

    2012-02-01

    The scope of this paper is to validate proposals used to qualify hospital food by the Brazilian scientific community. An electronic questionnaire was applied to clinical nutrition professionals registered on the Lattes Platform (Brazilian database of institutions and researchers' curricula in the areas of Science and Technology). The questionnaire incorporated a Likert scale and had spaces for comments. The themes dealt with patient participation, the nutritional and sensory quality of hospital diets, and planning and goals of the Hospital Food and Nutrition Service (HFNS). The questionnaire also asked for the top five priorities for a HFNS. Proposals with total or partial adherence equal to or greater than 70% were considered to be approved. All proposals had total adherence equal to or greater than 70%. The proposal that had minimal adherence (70%) was the one that proposed that nutritional intervention must be arranged by mutual agreement with the patient. The proposal that had maximal adherence (93%) was the one advocating that there must be statistical control on diets prescribed by the HFNS. The most cited priorities referred to infrastructure and training of human resources (40%), the quality of hospital food (27%) and the nutritional status of the patient.

  20. Home Modification

    MedlinePlus

    ... it is important to consider certain safety modifications. Adaptations such as those in the following list can ... The importance of a Consumer Perspective in Home Adaptation of Alzheimer’s Households” (Chapter 6 pp 91-112) ...

  1. 76 FR 24060 - Proposed Extension of Existing Information Collection; Testing, Evaluation, and Approval of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ..., Evaluation, and Approval of Mining Products AGENCY: Mine Safety and Health Administration. ACTION: Notice of... inspection, testing, approval and certification, and quality control of mining equipment and...

  2. 48 CFR 2052.215-79 - Contract award and evaluation of proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... REGULATORY COMMISSION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and... the source selection authority in evaluating performance or schedule risk. (j) A written award...

  3. Ubiquitin modifications

    PubMed Central

    Swatek, Kirby N; Komander, David

    2016-01-01

    Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid protein ubiquitin is subjected to further modifications, creating a multitude of distinct signals with distinct cellular outcomes, referred to as the 'ubiquitin code'. Ubiquitin can be ubiquitinated on seven lysine (Lys) residues or on the N-terminus, leading to polyubiquitin chains that can encompass complex topologies. Alternatively or in addition, ubiquitin Lys residues can be modified by ubiquitin-like molecules (such as SUMO or NEDD8). Finally, ubiquitin can also be acetylated on Lys, or phosphorylated on Ser, Thr or Tyr residues, and each modification has the potential to dramatically alter the signaling outcome. While the number of distinctly modified ubiquitin species in cells is mind-boggling, much progress has been made to characterize the roles of distinct ubiquitin modifications, and many enzymes and receptors have been identified that create, recognize or remove these ubiquitin modifications. We here provide an overview of the various ubiquitin modifications present in cells, and highlight recent progress on ubiquitin chain biology. We then discuss the recent findings in the field of ubiquitin acetylation and phosphorylation, with a focus on Ser65-phosphorylation and its role in mitophagy and Parkin activation. PMID:27012465

  4. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Early termination of research support: Evaluation... SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.123 Early termination of research support: Evaluation of applications and...

  5. 76 FR 62813 - Pilot Program To Evaluate Proposed Proprietary Name Submissions; Public Meeting on Pilot Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... those evaluations for FDA to review. FDA anticipated holding a public meeting at the end of fiscal year... the best test methods for proprietary name evaluation. DATES: Submit either electronic or written... to register for and submit data to the voluntary pilot program. FDA stated that at the end of...

  6. 78 FR 47326 - Proposed Collection; 60-Day Comment Request: Community Evaluation of the National Diabetes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    ... Evaluation of the National Diabetes Education Program's Diabetes HealthSense Web site Summary: In compliance... Evaluation of the National Diabetes Education Program's Diabetes HealthSense Web site. 0925-NEW, National... satisfaction with NDEP resources such as the Diabetes HealthSense Web site; (2) Assess the extent to...

  7. 77 FR 30045 - 30-Day Notice of Proposed Information Collection: English Language Evaluation Surveys

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Information Collection: English Language Evaluation Surveys ACTION: Notice of request for public comment and... English Language Evaluation, to conduct surveys of participants in the ETA Program, E-Teacher Scholarship program, and the English Language Specialist Program. Participants are those who went on the...

  8. The Under-Examined Life: A Proposal for Critically Evaluating Teachers' and Students' Philosophies of Teaching

    ERIC Educational Resources Information Center

    Reber, Jeffrey

    2011-01-01

    Teachers are encouraged to critically evaluate their philosophy of teaching and to help students recognize and examine their implicit ideas about education as well. This critical evaluation entails examining assumptions about teaching and learning, investigating the implications that follow from those assumptions, and considering alternative ideas…

  9. An evaluation of EPA`s proposed national sediment quality criteria applied to Puget Sound

    SciTech Connect

    Gries, T.H.

    1994-12-31

    The US Environmental Protection Agency (EPA) proposed national marine and freshwater sediment quality criteria for five chemicals of concern: acenaphthene, dieldrin, endrin, fluoranthene and phenanthrene. The criteria values EPA developed were based on an equilibrium partitioning approach and are normalized to the organic carbon of the sediment. The Department of Ecology compared the proposed national marine sediment criteria for the three PAH compounds to Washington`s Sediment Management Standards (173-204 WAC), most of which were derived using the empirical ``Apparent Effects Threshold`` approach. The number of stations in Puget Sound exceeding the State`s chemical Sediment Quality Standards (SQS) was 1.7--8.1 times greater those exceeding the proposed criteria. It also appeared from early results that the latter were less sensitive predictors of stations known to exhibit significant adverse biological effects. Thus, the proposed criteria may not be as effective as the SQS when used as a regulatory tool to screen for biological effects in Puget Sound. These and other findings will be presented which generally support the EPA Science Advisory Board recommendation to use proposed national criteria in conjunction with other chemical and biological sediment quality indicators to make regulatory decisions.

  10. Evaluation of three simple direct or indirect carbonyl detection methods for characterization of oxidative modifications of proteins.

    PubMed

    Vásquez-Garzón, Verónica R; Rouimi, Patrick; Jouanin, Isabelle; Waeg, Georg; Zarkovic, Neven; Villa-Treviño, Saul; Guéraud, Françoise

    2012-05-01

    Among disruptions induced by oxidative stress, modifications of proteins, particularly irreversible carbonylation, are associated with the development of several diseases, including cardiovascular diseases, neurodegenerative diseases, and cancer. Carbonylation of proteins can occur directly or indirectly through the adduction of lipid oxidation products. In this study, three classical and easy-to-perform techniques to detect direct or indirect carbonylation of proteins were compared. A model protein apomyoglobin and a complex mixture of rat liver cytosolic proteins were exposed to cumene hydroperoxide oxidation or adduction to the lipid peroxidation product 4-hydroxynonenal in order to test direct or indirect carbonylation, respectively. The technique using a specific anti-4-hydroxynonenal-histidine adduct antibody was effective to detect in vitro modification of model apomyoglobin and cytosolic proteins by 4-hydroxynonenal but not by direct carbonylation which was achieved by techniques using biotin-coupled hydrazide or dinitrophenylhydrazine derivatization of carbonyls. Sequential use of these methods enabled the detection of both direct and indirect carbonyl modification in proteins, although constitutively biotinylated proteins were detected by biotin-hydrazide. Although rather classical and efficient, methods for carbonyl detection on proteins in oxidative stress studies may be biased by some artifactual detections and complicated by proteins multimerizations. The use of more and more specific available antibodies is recommended to complete detection of lipid peroxidation product adducts on proteins.

  11. Acoustic startle modification as a tool for evaluating auditory function of the mouse: Progress, pitfalls, and potential.

    PubMed

    Lauer, Amanda M; Behrens, Derik; Klump, Georg

    2017-03-19

    Acoustic startle response (ASR) modification procedures, especially prepulse inhibition (PPI), are increasingly used as behavioral measures of auditory processing and sensorimotor gating in rodents due to their perceived ease of implementation and short testing times. In practice, ASR and PPI procedures are extremely variable across animals, experimental setups, and studies, and the interpretation of results is subject to numerous caveats and confounding influences. We review considerations for modification of the ASR using acoustic stimuli, and we compare the sensitivity of PPI procedures to more traditional operant psychoacoustic techniques. We also discuss non-auditory variables that must be considered. We conclude that ASR and PPI measures cannot substitute for traditional operant techniques due to their low sensitivity. Additionally, a substantial amount of pilot testing must be performed to properly optimize an ASR modification experiment, negating any time benefit over operant conditioning. Nevertheless, there are some circumstances where ASR measures may be the only option for assessing auditory behavior, such as when testing mouse strains with early-onset hearing loss or learning impairments.

  12. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  13. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  14. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  15. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  16. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  17. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  18. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  19. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  20. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  1. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition...

  2. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition...

  3. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition...

  4. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition...

  5. 76 FR 73737 - Notice of Opportunity for Public Comment on the Proposed Model Safety Evaluation for Plant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... . From this page, the public can gain entry into ADAMS, which provides text and image files of NRC's... COMMISSION Notice of Opportunity for Public Comment on the Proposed Model Safety Evaluation for Plant...: Notice of opportunity for public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC)...

  6. PROPOSED STANDARD TO GREATLY EXPAND PUBLIC ACCESS AND EXPLORATION OF TOXICITY DATA: EVALUATION OF STRUCTURE DATA FILE FORMAT

    EPA Science Inventory



    PROPOSED ST ANDARD TO GREA TL Y EXP AND PUBLIC ACCESS AND EXPLORATION OF TOXICITY DATA: EVALUATION OF STRUCTURE DATA FILE FORMAT

    The ability to assess the potential toxicity of environmental, pharmaceutical, or industrial chemicals based on chemical structure in...

  7. 23 CFR 636.302 - Are there any limitations on the selection and use of proposal evaluation factors?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal Evaluation Factors § 636.302... construction is a significant component of the scope of work. However, where the contracting agency elects to... contracting agency wishes to use Federal-aid highway funds for final design and construction, the...

  8. 23 CFR 636.302 - Are there any limitations on the selection and use of proposal evaluation factors?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal Evaluation Factors § 636.302... construction is a significant component of the scope of work. However, where the contracting agency elects to... contracting agency wishes to use Federal-aid highway funds for final design and construction, the...

  9. 23 CFR 636.302 - Are there any limitations on the selection and use of proposal evaluation factors?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal Evaluation Factors § 636.302... construction is a significant component of the scope of work. However, where the contracting agency elects to... contracting agency wishes to use Federal-aid highway funds for final design and construction, the...

  10. A Proposal of Product Development Collaboration Method Using User Support Information and its Experimental Evaluation

    NASA Astrophysics Data System (ADS)

    Tanaka, Mitsuru; Kataoka, Masatoshi; Koizumi, Hisao

    As the market changes more rapidly and new products continue to get more complex and multifunctional, product development collaboration with competent partners and leading users is getting more important to come up with new products that are successful in the market in a timely manner. ECM (engineering chain management) and SCM (supply chain management) are supply-side approaches toward this collaboration. In this paper, we propose a demand-side approach toward product development collaboration with users based on the information gathered through user support interactions. The approach and methodology proposed here was applied to a real data set, and its effectiveness was verified.

  11. Evaluation and modification of five techniques for estimating stormwater runoff for watersheds in west-central Florida

    USGS Publications Warehouse

    Trommer, J.T.; Loper, J.E.; Hammett, K.M.

    1996-01-01

    Several traditional techniques have been used for estimating stormwater runoff from ungaged watersheds. Applying these techniques to water- sheds in west-central Florida requires that some of the empirical relationships be extrapolated beyond tested ranges. As a result, there is uncertainty as to the accuracy of these estimates. Sixty-six storms occurring in 15 west-central Florida watersheds were initially modeled using the Rational Method, the U.S. Geological Survey Regional Regression Equations, the Natural Resources Conservation Service TR-20 model, the U.S. Army Corps of Engineers Hydrologic Engineering Center-1 model, and the Environmental Protection Agency Storm Water Management Model. The techniques were applied according to the guidelines specified in the user manuals or standard engineering textbooks as though no field data were available and the selection of input parameters was not influenced by observed data. Computed estimates were compared with observed runoff to evaluate the accuracy of the techniques. One watershed was eliminated from further evaluation when it was determined that the area contributing runoff to the stream varies with the amount and intensity of rainfall. Therefore, further evaluation and modification of the input parameters were made for only 62 storms in 14 watersheds. Runoff ranged from 1.4 to 99.3 percent percent of rainfall. The average runoff for all watersheds included in this study was about 36 percent of rainfall. The average runoff for the urban, natural, and mixed land-use watersheds was about 41, 27, and 29 percent, respectively. Initial estimates of peak discharge using the rational method produced average watershed errors that ranged from an underestimation of 50.4 percent to an overestimation of 767 percent. The coefficient of runoff ranged from 0.20 to 0.60. Calibration of the technique produced average errors that ranged from an underestimation of 3.3 percent to an overestimation of 1.5 percent. The average

  12. H Scan/AHP decision process planning for evaluating and ranking of proposals submitted to the DOE hydrogen program

    SciTech Connect

    Szoka de Valladares, M.R.; Mack, S.

    1995-09-01

    The DOE Hydrogen Program needs to develop criteria as part of a systematic evaluation process for proposal identification, evaluation and selection. The H Scan component of this process provides a framework in which a project proposer can fully describe their candidate technology system and its components. The H Scan complements traditional methods of capturing cost and technical information. It consists of a special set of survey forms designed to elicit information so expert reviewers can assess the proposal relative to DOE specified selection criteria. The Analytic Hierarchy Process (AHP) component of the decision process assembles the management defined evaluation and selection criteria into a coherent multi-level decision construct by which projects can be evaluated in pair-wise comparisons. The AHP model will reflect management`s objectives and it will assist in the ranking of individual projects based on the extent to which each contributes to management`s objectives. This paper contains a detailed description of the products and activities associated with the planning and evaluation process: The objectives or criteria; the H Scan; and The Analytic Hierarchy Process (AHP).

  13. 77 FR 35665 - Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... number of students who are achieving proficiency ] on state assessments of math and reading. The CSP... part of its annual review of Mathematics and Science Partnership final-year evaluations. The...

  14. 76 FR 70470 - Notice of Submission of Proposed Information Collection to OMB Evaluation of the Veterans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... Veterans Homelessness Prevention Demonstration AGENCY: Office of Policy Development and Research, HUD... Veterans Homelessness Prevention Demonstration (VHPD). The Department solicits public comments on the... approval to collect information to evaluate the Veterans Homelessness Prevention Demonstration. The FY...

  15. 22 CFR 225.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.123 Early termination of research support: Evaluation of... the protection of the rights and welfare of human subjects (whether or not the research was subject...

  16. 77 FR 60746 - Proposed Information Collection (VA/DOD Joint Disability Evaluation Board Claim) Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ... Interagency Task Force on Returning Global War on Terror Heroes, VA and the Department of Defense (DOD) have agreed to develop a joint process in which Global War on Terror (GWOT) service members are evaluated...

  17. 75 FR 62543 - Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... (NIH) will publish periodic summaries of proposed projects to be submitted to the Office of Management... biomedical research is conducted nationwide by reducing the time it takes for basic science or laboratory... transformational changes in clinical and translational science among academic medical centers and their...

  18. 48 CFR 2052.215-79 - Contract award and evaluation of proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the proposal shall result in a binding contract without further action by either party. (k) A separate... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract award and... REGULATORY COMMISSION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions...

  19. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government assumes no liability for the use or disclosure of information (data) not made subject to such... information (data) before decision as to the award of a contract, or the transfer of valuable and sensitive..., to the extent permitted by law, none of the information (data) contained in proposals, except...

  20. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Government assumes no liability for the use or disclosure of information (data) not made subject to such... information (data) before decision as to the award of a contract, or the transfer of valuable and sensitive..., to the extent permitted by law, none of the information (data) contained in proposals, except...

  1. 77 FR 56634 - Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... processes for all K-12 educational programs, has transformed the way in which ED collects and uses data...-56635] [FR Doc No: 2012-22508] DEPARTMENT OF EDUCATION Notice of Proposed Information Collection... and Secondary Education Data Through EDFacts SUMMARY: The collection, use, and reporting of...

  2. 14 CFR § 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  3. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  4. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  5. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  6. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  7. DNA modifications: Another stable base in DNA

    NASA Astrophysics Data System (ADS)

    Brazauskas, Pijus; Kriaucionis, Skirmantas

    2014-12-01

    Oxidation of 5-methylcytosine has been proposed to mediate active and passive DNA demethylation. Tracking the history of DNA modifications has now provided the first solid evidence that 5-hydroxymethylcytosine is a stable epigenetic modification.

  8. Proposed amendment for Presidential Permit PP-63 and associated modifications to 500 kV international transmission line, Forbes, Minnesota to Manitoba, Canada Northern States Power Company. Final Environmental Assessment

    SciTech Connect

    Not Available

    1992-02-01

    Northern States Power Company, (NSP), a Minnesota investor owned utility has applied to the Office of Fossil Energy, United States Department of Energy, to amend Presidential Permit PP-63 to allow for alterations to the 500 kV transmission line and as sedated facilities currently regulated by this permit. The alterations proposed for the 500 kV line owned by NSP are part of a long term effort sponsored by NSP to upgrade the existing NSP transmission system to allow for increased exchange of electricity with the Manitoba Hydro-Electric Board. Presidential Permit PP-63 authorized NSP to construct, connect, operate and maintain a 500 kV line at the United States/Canadian border approximately seven-and-a-half miles west of Warroad in Roseau County, Minnesota. This line connects with a 500 kV line owned and operated by the Manitoba Hydro-Electric Board (MHEB), which extends from Dorsey, Manitoba, Canada to the United States/Canadian border. NSP proposes to increase the electricity transfer capability of this transmission facility by constructing a new 80-acre substation on the existing 500 kV line in Roseau County, Minnesota, and upgrading the existing substation at Forbes, Minnesota. The proposed Roseau substation would contain two 41.5 ohm series capacitor banks. In addition, static VAR compensators are to be installed at the existing Forbes Substation. Approximately 5 acres would be added to the 30-acre Forbes site to house the additional equipment. No new lines would enter or exit the facility. NSP proposes to place the new Roseau Substation in service in May 1993 and to complete the upgrading of the Forbes Substation in March 1994. The primary, initial purpose of these modifications is to enable NSP to import 400 megawatts of electric power from MHEB during the summer months to meet peak electrical demand in the Minneapolis-St. Paul area. It is expected that this power transfer would begin in 1993.

  9. Proposal of a taste evaluating method of the sponge cake by using 3D range sensor

    NASA Astrophysics Data System (ADS)

    Kato, Kunihito; Yamamoto, Kazuhiko; Ogawa, Noriko

    2002-10-01

    Nowadays, the image processing techniques are while applying to the food industry in many situations. The most of these researches are applications for the quality control in plants, and there are hardly any cases of measuring the 'taste'. We are developing the measuring system of the deliciousness by using the image sensing. In this paper, we propose the estimation method of the deliciousness of a sponge cake. Considering about the deliciousness of the sponge cake, if the size of the bubbles on the surface is small and the number of them is large, then it is defined that the deliciousness of the sponge cake is better in the field of the food science. We proposed a method of detection bubbles in the surface of the sectional sponge cake automatically by using 3-D image processing. By the statistical information of these detected bubbles based on the food science, the deliciousness is estimated.

  10. Issues to be Considered in the Evaluation of Technical Proposals from the Ada (Trademark) Language Perspective.

    DTIC Science & Technology

    2014-09-26

    facilities (software test bed, dynamic simulation) are proposed to support the testing phases? 17. What proprietary data rights (if any) are...and beginners; for example, is prompting via menus provided for beginners and single keystroke capability provided for experienced users? 2-13 - input...Statement of Work: - constraint and numeric error checking - dynamic storage management - exception management 2-1 * 2.3 IMPLEMENTATION LANGUAGE If Ada has

  11. [Evaluation of interventions intended to reduce psychosocial work stress. Proposal for a classification scheme].

    PubMed

    Neuner, R; Bauer, J; Nübling, M; Rose, U; Krause, A

    2011-08-01

    Evidence for the effectiveness of measures aiming to reduce psychosocial work stress is sporadic. This is contradictory to the requirement identified by the German Social Security Code (SGB VII) that interventions constitute the most important method of maintaining and improving employees' health. Reasons for this can be seen in the complexity of the subject and methodological issues concerning scientific standards. In addition, agreed quality standards are nonexistent for the evaluation of intervention measures. For this reason, a synopsis of existing audit and evaluation schemes was performed, thus, resulting in refined and adapted quality standards for intervention measures aiming to reduce psychosocial work stress. The quality criteria presented in this paper comprise aims, effectiveness, and facilitators, each being composed of several indicators. The criteria are designed as quality indicators which translate the outcome of an evaluation into quality figures. The process is transparent and offers a rational basis for communication, planning, and decision-making in health promotion.

  12. Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.

    PubMed

    Casimiro-Garcia, Agustin; Bigge, Christopher F; Davis, Jo Ann; Padalino, Teresa; Pulaski, James; Ohren, Jeffrey F; McConnell, Patrick; Kane, Christopher D; Royer, Lori J; Stevens, Kimberly A; Auerbach, Bruce J; Collard, Wendy T; McGregor, Christine; Fakhoury, Stephen A; Schaum, Robert P; Zhou, Hairong

    2008-05-01

    A new series of alpha-aryl or alpha-heteroarylphenyl propanoic acid derivatives was synthesized that incorporate acetylene-, ethylene-, propyl-, or nitrogen-derived linkers as a replacement of the commonly used ether moiety that joins the central phenyl ring with the lipophilic tail. The effect of these modifications in the binding and activation of PPARalpha and PPARgamma was first evaluated in vitro. Compounds possessing suitable profiles were then evaluated in the ob/ob mouse model of type 2 diabetes. The propylene derivative 40 and the propyl derivative 53 demonstrated robust plasma glucose lowering activity in this model. Compound 53 was also evaluated in male Zucker diabetic fatty rats and was found to achieve normalization of glucose, triglycerides, and insulin levels. An X-ray crystal structure of the complex of 53 with the PPARgamma-ligand-binding domain was obtained and discussed in this report.

  13. Evaluation of six NEHRP B/C crustal amplification models proposed for use in western North America

    USGS Publications Warehouse

    Boore, David; Campbell, Kenneth W.

    2016-01-01

    We evaluate six crustal amplification models based on National Earthquake Hazards Reduction Program (NEHRP) B/C crustal profiles proposed for use in western North America (WNA) and often used in other active crustal regions where crustal properties are unknown. One of the models is based on an interpolation of generic rock velocity profiles previously proposed for WNA and central and eastern North America (CENA), in conjunction with material densities based on an updated velocity–density relationship. A second model is based on the velocity profile used to develop amplification factors for the Next Generation Attenuation (NGA)‐West2 project. A third model is based on a near‐surface velocity profile developed from the NGA‐West2 site database. A fourth model is based on velocity and density profiles originally proposed for use in CENA but recently used to represent crustal properties in California. We propose two alternatives to this latter model that more closely represent WNA crustal properties. We adopt a value of site attenuation (κ0) for each model that is either recommended by the author of the model or proposed by us. Stochastic simulation is used to evaluate the Fourier amplification factors and their impact on response spectra associated with each model. Based on this evaluation, we conclude that among the available models evaluated in this study the NEHRP B/C amplification model of Boore (2016) best represents median crustal amplification in WNA, although the amplification models based on the crustal profiles of Kamai et al. (2013, 2016, unpublished manuscript, see Data and Resources) and Yenier and Atkinson (2015), the latter adjusted to WNA crustal properties, can be used to represent epistemic uncertainty.

  14. 40 CFR 26.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Early termination of research support... PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.123 Early termination of research support: Evaluation...

  15. 75 FR 20977 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... Request--Evaluation of Reaching the Underserved Elderly and Working Poor in SNAP AGENCY: Food and... Elderly and Working Poor in SNAP. DATES: Written comments must be received on or before June 21, 2010... Underserved Elderly and Working Poor in SNAP: FY 2009 Pilots. Form Number: OMB Number: Expiration Date:...

  16. Federal Clearance of Educational Evaluation Instruments Procedural Problems and Proposed Remedies

    ERIC Educational Resources Information Center

    Carter, Launor

    1977-01-01

    Presents a case study of how the review and clearance procedures are operating for evaluation instruments used in collecting information in connection with studies for the U.S. Office of Education. The review procedures are defective: They consume too much time. They are very costly. The results are unproductive. (Author/JM)

  17. 78 FR 48879 - Proposed Collection; 60-day Comment Request: Outcomes Evaluation of the National Cancer Institute...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ... Evaluation of the National Cancer Institute (NCI) Cancer Prevention Fellowship Program (CPFP) SUMMARY: In..., Cancer Prevention Fellowship Program, National Cancer Institute, 9609 Medical Center Drive, Room 2W136... Fellowship Program (CPFP), 0925-NEW, National Cancer Institute (NCI), National Institutes of Health...

  18. 78 FR 40760 - 60-Day Notice of Proposed Information Collection: Training Evaluation Form

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ... HUD web-based learning materials. Respondents (i.e., affected public): The training evaluation form... training will be web-based in the future. To inspect HUD insured and assisted properties, prospective...) inspection training. The training consists of pre- requisite computer-based component followed by...

  19. Technical Evaluations of Proposed Remote-Handled Transuranic Waste Characterization Requirements at WIPP

    SciTech Connect

    Anastas, G.; Channell, J. K.

    2002-02-26

    Characterization, packaging, transport, handling and disposal of remotely handled transuranic (RH TRU) waste at WIPP will be different than similar operations with contact handled transuranic (CH TRU) waste. This paper presents results of technical evaluations associated with the planned disposal of remotely handled transuranic waste at the Waste Isolation Pilot Plant (WIPP).

  20. 77 FR 34047 - Medicare Program; Proposal Evaluation Criteria and Standards for End Stage Renal Disease (ESRD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... and Standards for End Stage Renal Disease (ESRD) Network Organizations AGENCY: Centers for Medicare... procedures we will use to evaluate an End-Stage Renal Disease (ESRD) Network Organization's capabilities to perform, and actual performance of, the duties and functions under the ESRD Network Statement of Work...

  1. Rigor, Impact and Prestige: A Proposed Framework for Evaluating Scholarly Publications

    ERIC Educational Resources Information Center

    West, Richard E.; Rich, Peter J.

    2012-01-01

    As publication pressure has increased in the world of higher education, more journals, books, and other publication outlets have emerged. Thus it is critical to develop clear criteria for effectively evaluating the quality of publication outlets. Without such criteria funding agencies and promotion committees are forced to guess at how to evaluate…

  2. Proposals for the Evaluation of Personnel Readiness during a Company Inspection in the German Army.

    DTIC Science & Technology

    1982-10-01

    areas such as administration and maintenan-e and a general 5.4 percent surplus of draftees [Ref. 22: p. 220].But this sur- plus does not make up for...controvirsial part of the evaluation of a military unit. Because the 32 difficulties in assessing them objectively under the cordi - tions of an inspection

  3. 78 FR 59706 - Proposed Collection; 30-Day Comment Request; Evaluation of a Kidney Disease Education and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... control number. ] Direct Comments to OMB: Written comments and/or suggestions regarding the item(s..., NIDDK, NIH, Building 31, Room 9A06, 9000 Rockville Pike, Bethesda, MD 20892, or call non-toll-free... pilot evaluation will assess: (a) Overall quality of the program from the client and...

  4. Re-Framing Teacher Evaluation Discourse in the Media: An Analysis and Narrative-Based Proposal

    ERIC Educational Resources Information Center

    Ulmer, Jasmine B.

    2016-01-01

    Recent publications by major newspapers in the USA have reinforced the perception that teacher quality represents a national crisis. By releasing individual teacher evaluation data in online, searchable databases, several newspapers have influenced public perceptions of teachers and teaching. A framing analysis of selected media events and…

  5. 77 FR 2743 - Notice of Proposed Information Collection for Public Comment: Choice Neighborhoods Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... research design calls for the collection of a random sample at the Chicago and New Orleans sites, and... Evaluation, Phase I AGENCY: Office of the Assistant Secretary for Policy Development and Research, HUD... to Paul.A.Joice@hud.gov or in hard copy to: Paul Joice, Office of Policy Development and...

  6. 77 FR 39490 - Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...-12 students. The U.S. Department of Education (ED) is interested in gaining a thorough understanding... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION...; Evaluation of the Carol M. White Physical Education Program SUMMARY: The Carol M. White Physical...

  7. Methodology for Scour Evaluation of US Army Installation Bridges: A Proposed Evaluation for Scour Risk and Channel Instability

    DTIC Science & Technology

    2013-01-01

    if the situation is critical, consult a specialist. River stability analysis near road The evaluation and design of a roadway stream crossing should...of a river , similar to the curve of a pipe. ERDC/GSL TR-13-1 21 Braided channel Created when a stream channel is divided into several smaller ones...distances, the thalweg tends to be sinuous due to the instability of the alternate bars. Stream A body of water that might range from a large river

  8. Hydrologic study and evaluation of Ish Creek watershed (West Chestnut Ridge proposed disposal site)

    SciTech Connect

    Huff, D.D.; Elmore, J.L.; Farmer, D.C.

    1984-03-01

    As part of site characterization work for the proposed West Chestnut Ridge Central Waste Disposal Facility, hydrologic information has been assembled from literature sources and direct field measurements. Earlier studies provide the basis for estimating flow frequency and expected high and low flows for catchments on Knox Group formations. Seven waterflow-gaging installations were established and used to characterize runoff patterns in the study area. Based on findings of this study, a practical design capacity for a flume to measure site runoff would range between 1 and 3000 L/s, although flows up to 4500 L/s (10-year recurrence interval) may be encountered. 7 references, 2 figures, 5 tables.

  9. Evaluation of Proposed Rocket Engines for Earth-to-Orbit Vehicles

    NASA Technical Reports Server (NTRS)

    Martin, James A.; Kramer, Richard D.

    1990-01-01

    The objective is to evaluate recently analyzed rocket engines for advanced Earth-to-orbit vehicles. The engines evaluated are full-flow staged combustion engines and split expander engines, both at mixture ratios at 6 and above with oxygen and hydrogen propellants. The vehicles considered are single-stage and two-stage fully reusable vehicles and the Space Shuttle with liquid rocket boosters. The results indicate that the split expander engine at a mixture ratio of about 7 is competitive with the full-flow staged combustion engine for all three vehicle concepts. A key factor in this result is the capability to increase the chamber pressure for the split expander as the mixture ratio is increased from 6 to 7.

  10. Evaluation of Dredged Material Proposed for Ocean Disposal from Port Chester, New York

    SciTech Connect

    Barrows, E.S.; Mayhew, H.L.; Word, J.Q.; Tokos, J.J.S.

    1996-08-01

    Port Chester was one of seven waterways that the US Army Corps of Engineers-New York District requested the Battelle Marine Sciences Laboratory to sample and evaluate for dredging and disposal in March 1994. Tests and analyses were conducted on Port Chester sediment core samples. Because the Port Chester area is located on the border between New York and southeast Connecticut, its dredged material may also be considered for disposal at the Central Long Island Sound Disposal Site. The sediment evaluation consisted of bulk sediment chemical analyses, chemical analyses of site water and dredged material elutriate preparations, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Port Chester were analyzed for grain size, moisture content, and total organic carbon. In addition, sediment was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl congers, polynuclear aromatic hydrocarbons and 1,4-dichlorobenzene.

  11. Reactor building temperature reduction project data acquisition, evaluations and proposed actions. Arkansas nuclear one, Unit 1

    SciTech Connect

    France, E.R.

    1991-06-01

    On August 1, 1987 Arkansas Power and Light maintenance personnel made a power entry at Arkansas Nuclear One, Unit 1. They discovered that the steam generator cavity temperature was too high for personnel comfort. AP and L management requested that the available temperature data be recorded throughout the reactor building (RB). Hand held thermometers, infrared thermography, and existing RTD`s were utilized. Temperatures were found to range from 100F near the basement to 165F in the dome area. A temperature of 183F was found above the A steam generator cavity. As a result of this finding, AP and L and the Nuclear Regulatory Commission decided that an in depth evaluation of the RB temperatures and their effect on the safe operation of the plant was needed. The original design temperature was 110F. This section discusses the monitoring systems installed, the results of the evaluation and the corrective actions taken.

  12. A proposed wind measurement and analysis approach for evaluating a prospective wind plant site

    NASA Astrophysics Data System (ADS)

    Wendell, L. L.; Barnard, J. C.; Morris, V. R.

    1994-05-01

    On the basis of research results, cooperative efforts with wind energy developers, and work with meteorological consultants, Pacific Northwest Laboratory (PNL) has proposed an approach for performing wind measurement assessments for prospective wind plant sites. The primary goal of this approach is to effectively balance comprehensiveness with expense. The approach begins with the acquisition of high-resolution digital terrain data for the site. These data are used in computational and visual analyses to determine the best locations for a reference tower and several satellite towers used for wind measurements. The reference tower has wind sensors at three levels: 20, 30, and 40 m. The satellite towers have one sensor at 30 m. The sensors measure the vertical wind speed as well as the horizontal speed and direction. The sampling rate must be at least 4 times per second. The data acquisition system keeps track of turbulence statistics that are saved at intervals from ten minutes to one hour. Statistics for the 30-m level at the satellite towers, as well as the reference tower, provide the mean and variance of the total speed and covariances of the component speeds. The data base produced by this approach over 1-2 years should be valuable for both routine and in-depth analyses. This approach takes advantage of some recent technological developments. It is not being proposed as a standard at this time, but as a tool to be refined with experience.

  13. A PROPOSAL FOR MAKING A RISK MAP OF ROCKFALL BY EVALUATING THE INFLUENCE TO RAILWAY TRACK

    NASA Astrophysics Data System (ADS)

    Fukata, Takahiro; Mori, Taiki; Shibuya, Satoru

    An incident of rockfall may trigger serious damage to the safety as well as the after-the-event maintenance of railway transportation. In an attempt to minimize such damage caused by rockfall incident, the railway companies regularly in spect the concerned slopes along the railway, and take necessary measures. In the current practice, however, it is very difficult to make a full control of slopes in danger spreading over the wide area due to the limited human and financial resources. Accordingly, it is urgently needed for the railway firms to establish cost-effective as well as reliable system for the slope management. A risk map based on the impact statement of rockfall to railway track is of great use for not only enhancing the efficiency of slope inspection, but also planning the disaster prevention of railway. In this paper, a methodology for establishing a risk map by considering the impact statement to railway truck in a quantitative manner is proposed. In so doing, the rockfall movement on a slope was numerically simulated in match with each categorized type of slopes. The applicability of this proposed method for the slope management practice is examined based on a number of case histories.

  14. New partial skeletons of Palaeocene Nyctitheriidae and evaluation of proposed euarchontan affinities

    PubMed Central

    Manz, Carly L.; Chester, Stephen G. B.; Bloch, Jonathan I.; Silcox, Mary T.; Sargis, Eric J.

    2015-01-01

    Small-bodied, insectivorous Nyctitheriidae are known in the Palaeogene fossil record almost exclusively from teeth and fragmentary jaws and have been referred to Eulipotyphla (shrews, moles and hedgehogs) based on dental similarities. By contrast, isolated postcrania attributed to the group suggest arboreality and a relationship to Euarchonta (primates, treeshrews and colugos). Cretaceous–Palaeocene adapisoriculid insectivores have also been proposed as early euarchontans based on postcranial similarities. We describe the first known dentally associated nyctitheriid auditory regions and postcrania, and use them to test the proposed relationship to Euarchonta with cladistic analyses of 415 dental, cranial and postcranial characteristics scored for 92 fossil and extant mammalian taxa. Although nyctitheriid postcrania share similarities with euarchontans likely related to arboreality, results of cladistic analyses suggest that nyctitheriids are closely related to Eulipotyphla. Adapisoriculidae is found to be outside of crown Placentalia. These results suggest that similarities in postcranial morphology among nyctitheriids, adapisoriculids and euarchontans represent separate instances of convergence or primitive retention of climbing capabilities. PMID:25589486

  15. Role of Physical Evaluation in the Early Identification of Axial Spondyloarthritis: A Research Proposal

    PubMed Central

    Castro, Marcelo P; Stebbings, Simon M; Milosavljevic, Stephan; Bussey, Melanie D

    2015-01-01

    The aim of this study was to present a rationale to explore the use of clinical tests for the sacroiliac joints to detect early axial spondyloarthritis (SpA) and to suggest a protocol to validate these clinical tests. Based on the European Guidelines for Diagnosis and Treatments of Pelvic Girdle Pain, we propose a set of six clinical tests to identify the likely presence of inflammation in the sacroiliac joints associated with early axial SpA. As magnetic resonance imaging (MRI) is the current gold standard used to identify inflammation in the sacroiliac joints, the results of the proposed set of clinical tests are compared with those from the MRI examinations. We hypothesize that specific clinical tests, which combine pain provocation and functional tests, for assessing the sacroiliac joints will help to identify early active inflammation at the sacroiliac joints in axial SpA. If such tests prove to be sensitive and specific, they could add further value to the diagnostic classification criteria for axial SpA. PMID:26448694

  16. Population Sensitivity Evaluation of Two Proposed Hampton Roads Area Sites for a Possible Small Modular Reactor

    SciTech Connect

    Belles, R. J.; Omitaomu, O. A.

    2014-08-01

    The overall objective of this research project is to use the OR-SAGE tool to support the US Department of Energy (DOE) Office of Nuclear Energy (NE) in evaluating future electrical generation deployment options for small modular reactors (SMRs) in areas with significant energy demand from the federal sector. Deployment of SMRs in zones with high federal energy use can provide a means of meeting federal clean energy goals.

  17. Evaluation and proposed improvements to effectiveness of US Nuclear Regulatory Commission generic communications

    SciTech Connect

    Thurber, J.A.; Melber, B.D.; Geisendorfer, C.L.; Vallario, R.W.

    1988-01-01

    This report describes an evaluation of NRC generic communications with industry concerning safety related issues of commercial nuclear power plandts. The analysis builds on the findings presented in the 1986 Office of Analysis and Evaluation of Operational Data (AEOD) Special Study Report, ''An Overview of Nuclear Power Plant Operating Experience Feedback Programs'' (AEOD/S602). The primary objective of the report is to present practical recommendations for improving NRC's documents and generic communications system. The report is based upon a systematic review and evaluation of NRC and industry operating experience documents. It also includes an analysis of interviews with licensee personnel at five utilities and their nuclear power plants. NRC regional and headquarters managers and staff were also interviewed for the study. NRC and licensee personnel interviewed are generally satisfied with the current NRC-industry communications system; however, several problems and potential solutions to those problems are identified in this study. The report makes seven major recommendations for improvement in the effectiveness of NRC-industry generic communications about nuclear power plant operating experience.

  18. Evaluation of proposed hardness assurance method for bipolar linear circuits with enhanced low dose rate sensitivity (ELDRS)

    SciTech Connect

    Pease, R.L.; Gehlhausen, M.; Krieg, J.; Titus, J.; Turflinger, T.; Emily, D.; Cohn, L.

    1998-12-01

    Data are presented on several low dose rate sensitive bipolar linear circuits to evaluate a proposed hardness assurance method. The circuits include primarily operational amplifiers and voltage comparators with a variety of sensitive components and failure modes. The proposed method, presented in 1997, includes an option between a low dose rate test at 10 mrd(Si)/s and room temperature and a 100 C elevated temperature irradiation test at a moderate dose rate. The results of this evaluation demonstrate that a 10 mrd(Si)/s test is able (in all but one case) to bound the worst case response within a factor of 2. For the moderate dose rate, 100 C test the worst case response is within a factor of 3 for 8 of 11 circuits, and for some circuits overpredicts the low dose rate response. The irradiation bias used for these tests often represents a more degrading bias condition than would be encountered in a typical space system application.

  19. Proposal of global flood vulnerability scenarios for evaluating future potential flood losses

    NASA Astrophysics Data System (ADS)

    Kinoshita, Y.; Tanoue, M.; Watanabe, S.; Hirabayashi, Y.

    2015-12-01

    Flooding is one of the most hazardous and damaging natural disasters causing serious economic loss and casualties across the world (Jongman et al., 2015). Previous studies showed that the global temperature increase affects regional weather pattern, and several general circulation model (GCM) simulations suggest the increase of flood events in both frequency and magnitude in many parts of the world (Hirabayashi et al., 2013). Effective adaptation to potential flood risks under the warming climate requires an in-depth understanding of both the physical and socioeconomic contributors of the flood risk. To assess the realistic future potential flood risk, future sophisticated vulnerability scenarios associated with the shared socioeconomic pathways (SSPs) are necessary. In this study we propose a new future vulnerability scenarios in mortality. Our vulnerability scenarios are constructed based on the modeled flood exposure (population potentially suffered by flooding) and a past from 1980 to 2005. All the flood fatality data were classified according to four income levels (high, mid-high, mid-low and low). Our proposed scenarios have three pathways regarding to SSPs; High efficiency (HE) scenario (SSP1, SSP4 (rich country) and SSP5), Medium efficiency (ME) scenario (SSP2), and Low efficiency (LE) scenario (SSP3 and SSP4 (poor country)). The maximum mortality protection level on each category was detected by applying exponential curve fitting with offset term. Slopes in the HE scenario are assumed to be equal to slopes estimated by regression analysis in each category. The slope in the HE scenario is defined by the mean value of all countries' slope value that is approximately -0.33 mortality decreases per year. The EM-DAT mortality data shows a decreasing trend in time in almost all of the countries. Although mortalities in some countries show an increasing trend, this is because these countries were affected by once-in-hundred-years floods after 1990's. The slope in

  20. A proposed USAF fatigue evaluation program based upon recent systems experience

    NASA Technical Reports Server (NTRS)

    Haviland, G. P.; Purkey, G. F.

    1972-01-01

    The United States Air Force has published a document entitled Aircraft Structural Integrity Program. One phase of the program is concerned with the fatigue life certification of all types of military aircraft. The document describes the criteria, analyses, and tests that are necessary in order to satisfy the USAF fatigue life requirement. Some recent and valid criticism has been directed toward the document, particularly the fatigue-life requirements contained in it. Some changes are proposed based on surveys conducted in the United States and abroad as well as some recent systems' experience. The surveys covered both military and civilian organizations. The fatigue certification case histories of selected military and commercial aircraft are presented. The design development element tests, preproduction design verification tests, and full-scale fatigue tests of each are described. A brief status report on the revisions to the MIL-A-008860 series specifications is included.

  1. A methodological proposal to evaluate the cost of duration moral hazard in workplace accident insurance.

    PubMed

    Martín-Román, Ángel; Moral, Alfonso

    2017-02-21

    The cost of duration moral hazard in workplace accident insurance has been amply explored by North-American scholars. Given the current context of financial constraints in public accounts, and particularly in the Social Security system, we feel that the issue merits inquiry in the case of Spain. The present research posits a methodological proposal using the econometric technique of stochastic frontiers, which allows us to break down the duration of work-related leave into what we term "economic days" and "medical days". Our calculations indicate that during the 9-year period spanning 2005-2013, the cost of sick leave amongst full-time salaried workers amounted to 6920 million Euros (in constant 2011 Euros). Of this total, and bearing in mind that "economic days" are those attributable to duration moral hazard, over 3000 million Euros might be linked to workplace absenteeism. It is on this figure where economic policy measures might prove more effective.

  2. Instructional Improvement: Behavior Modification.

    ERIC Educational Resources Information Center

    Haring, Norris G.; Hayden, Alice H.

    Sixteen papers are provided. B. F. Skinner discusses the arrangement of contingencies for learning: Lloyd Homme describes behavioral engineering; and Frank Hewett considers behavior modification in special education. Also treated are experimental education by Norris Haring, program evaluation by Arthur Lumsdaine, and administration of special…

  3. Modification and Biological Evaluation of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion

    PubMed Central

    2015-01-01

    Fascin has recently emerged as a potential therapeutic target, as its expression in cancer cells is closely associated with tumor progression and metastasis. Following the initial discovery of a series of thiazole derivatives that demonstrated potent antimigration and antiinvasion activities via possible inhibition of fascin function, we report here the design and synthesis of 63 new thiazole derivatives by further structural modifications in search of more potent fascin inhibitors. The 5 series of analogues with longer alkyl chain substitutions on the thiazole nitrogen exhibited greater antimigration activities than those with other structural motifs. The most potent analogue, 5p, inhibited 50% of cell migration at 24 nM. Moreover, the thiazole analogues showed strong antiangiogenesis activity, blocking new blood vessel formation in a chicken embryo membrane assay. Finally, a functional study was conducted to investigate the mechanism of action via interaction with the F-actin bundling protein fascin. PMID:25007006

  4. Isothermal Microcalorimetric Evaluation of Compatibility of Proposed Injector Materials with High-Test Hydrogen Peroxide Propellant

    NASA Technical Reports Server (NTRS)

    Gostowski, Rudy

    2003-01-01

    High-test hydrogen peroxide (HTP) is receiving renewed interest as a monopropellant and as the oxidizer for bipropellant systems. HTP is hydrogen peroxide in concentrations ranging from 70 to 98%. All surfaces wetted by HTP must be evaluated for compatibility with the fluid. In the case of tanks, lines and valves compatibility is required to preserve the HTP oxygen and energy content and to avoid overpressurization due to decomposition. With injectors and regenerative cooling passages shorter exposure time reduces these concerns. However, phase changes from fluid to gas impact heat transfer and become the dominant compatibility concern. Isothermal microcalorimetry (IMC) provides a convenient and reproducible means to observe the decomposition of HTP when exposed to structural materials and therefore the compatibility of those materials'. The instrument provides heat flow values in terms of watts that may be converted to a reaction rate given the heat of reaction for the decomposition of hydrogen peroxide. These values are then converted to percent active oxygen loss per week (%AOL/wk) to preserve an earlier convention for quantifying HTP compatibility. Additionally, qualitative designations of compatibility have been assigned to these values. This scheme consists of four classes with Class 1 being the most compatible. While historical compatibility data is available its current applicability is in question due to subtle changes in the compositions of both HTP and structural materials. Trace levels of molecules can have significant influence on compatibility. Therefore representative samples of materials must be evaluated with current HTP formulations. In this work seven materials were selected for their strength characteristics at high temperature as expected in a HTP injector. The materials were then evaluated by IMC for HTP compatibility.

  5. 33 CFR 148.405 - What are the procedures for notifying the Commandant (CG-5) of proposed site evaluation and pre...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... notifying the Commandant (CG-5) of proposed site evaluation and pre-construction testing? 148.405 Section...) DEEPWATER PORTS DEEPWATER PORTS: GENERAL Site Evaluation and Pre-Construction Testing § 148.405 What are the procedures for notifying the Commandant (CG-5) of proposed site evaluation and pre-construction testing?...

  6. Proposal to optimize ecotoxicological evaluation of wastewater treated by conventional biological and ozonation processes.

    PubMed

    Wigh, Adriana; Devaux, Alain; Brosselin, Vanessa; Gonzalez-Ospina, Adriana; Domenjoud, Bruno; Aït-Aïssa, Selim; Creusot, Nicolas; Gosset, Antoine; Bazin, Christine; Bony, Sylvie

    2016-02-01

    A mixture of urban and hospital effluents (50% v/v) was evaluated for ecotoxicity with an advanced bioassay battery. Mixed effluents were tested before any treatment, after biological treatment alone, and after biological treatment followed by a tertiary ozonation (15 mg O3/L). Laying a high value on the continuance of organisms' fitness, essential to preserve a healthy receiving ecosystem, the main objective of this study was to combine normalized bioassays with newly developed in vivo and in vitro tests in order to assess alteration of embryo development, growth and reproduction, as well as genotoxic effects in aquatic organisms exposed to complex wastewater effluents. Comparison of the bioassays sensitivity was considered. Contrary to the lack of toxicity observed with normalized ecotoxicity tests, endpoints measured on zebrafish embryos such as developmental abnormalities and genotoxicity demonstrated a residual toxicity in wastewater both after a biological treatment followed or not by a tertiary O3 treatment. However, the ozonation step allowed to alleviate the residual endocrine disrupting potential measure in the biologically treated effluent. This study shows that normalized bioassays are not sensitive enough for the ecotoxicological evaluation of wastewaters and that there is a great need for the development of suitable sensitive bioassays in order to characterize properly the possible residual toxicity of treated effluents.

  7. A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections

    NASA Astrophysics Data System (ADS)

    Danis-Wlodarczyk, Katarzyna; Vandenheuvel, Dieter; Jang, Ho Bin; Briers, Yves; Olszak, Tomasz; Arabski, Michal; Wasik, Slawomir; Drabik, Marcin; Higgins, Gerard; Tyrrell, Jean; Harvey, Brian J.; Noben, Jean-Paul; Lavigne, Rob; Drulis-Kawa, Zuzanna

    2016-06-01

    Bacteriophage therapy is currently resurging as a potential complement/alternative to antibiotic treatment. However, preclinical evaluation lacks streamlined approaches. We here focus on preclinical approaches which have been implemented to assess bacteriophage efficacy against Pseudomonas biofilms and infections. Laser interferometry and profilometry were applied to measure biofilm matrix permeability and surface geometry changes, respectively. These biophysical approaches were combined with an advanced Airway Surface Liquid infection model, which mimics in vitro the normal and CF lung environments, and an in vivo Galleria larvae model. These assays have been implemented to analyze KTN4 (279,593 bp dsDNA genome), a type-IV pili dependent, giant phage resembling phiKZ. Upon contact, KTN4 immediately disrupts the P. aeruginosa PAO1 biofilm and reduces pyocyanin and siderophore production. The gentamicin exclusion assay on NuLi-1 and CuFi-1 cell lines revealed the decrease of extracellular bacterial load between 4 and 7 logs and successfully prevents wild-type Pseudomonas internalization into CF epithelial cells. These properties and the significant rescue of Galleria larvae indicate that giant KTN4 phage is a suitable candidate for in vivo phage therapy evaluation for lung infection applications.

  8. The British Climate Change Act: a critical evaluation and proposed alternative approach

    NASA Astrophysics Data System (ADS)

    Pielke, Roger A., Jr.

    2009-04-01

    This paper evaluates the United Kingdom's Climate Change Act of 2008 in terms of the implied rates of decarbonization of the UK economy for a short-term and a long-term target established in law. The paper uses the Kaya identity to structure the evaluation, employing both a bottom up approach (based on projections of future UK population, economic growth, and technology) and a top down approach (deriving implied rates of decarbonization consistent with the targets and various rates of projected economic growth). Both approaches indicate that the UK economy would have to achieve annual rates of decarbonization in excess of 4 or 5%. To place these numbers in context, the UK would have to achieve the 2006 carbon efficiency of France by about 2015, a level of effort comparable to the building of about 30 new nuclear power plants, displacing an equivalent amount of fossil energy. The paper argues that the magnitude of the task implied by the UK Climate Change Act strongly suggests that it is on course to fail, and discusses implications.

  9. A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections

    PubMed Central

    Danis-Wlodarczyk, Katarzyna; Vandenheuvel, Dieter; Jang, Ho Bin; Briers, Yves; Olszak, Tomasz; Arabski, Michal; Wasik, Slawomir; Drabik, Marcin; Higgins, Gerard; Tyrrell, Jean; Harvey, Brian J.; Noben, Jean-Paul; Lavigne, Rob; Drulis-Kawa, Zuzanna

    2016-01-01

    Bacteriophage therapy is currently resurging as a potential complement/alternative to antibiotic treatment. However, preclinical evaluation lacks streamlined approaches. We here focus on preclinical approaches which have been implemented to assess bacteriophage efficacy against Pseudomonas biofilms and infections. Laser interferometry and profilometry were applied to measure biofilm matrix permeability and surface geometry changes, respectively. These biophysical approaches were combined with an advanced Airway Surface Liquid infection model, which mimics in vitro the normal and CF lung environments, and an in vivo Galleria larvae model. These assays have been implemented to analyze KTN4 (279,593 bp dsDNA genome), a type-IV pili dependent, giant phage resembling phiKZ. Upon contact, KTN4 immediately disrupts the P. aeruginosa PAO1 biofilm and reduces pyocyanin and siderophore production. The gentamicin exclusion assay on NuLi-1 and CuFi-1 cell lines revealed the decrease of extracellular bacterial load between 4 and 7 logs and successfully prevents wild-type Pseudomonas internalization into CF epithelial cells. These properties and the significant rescue of Galleria larvae indicate that giant KTN4 phage is a suitable candidate for in vivo phage therapy evaluation for lung infection applications. PMID:27301427

  10. Evaluation of the Steel Creek ecosystem in relation to the proposed restart of L reactor

    SciTech Connect

    Smith, M.H.; Sharitz, R.R.; Gladden, J.B.

    1981-10-01

    Information is presented on the following subjects: habitat and vegetation, the avifauna, semi-aquatic and terrestrial vertebrates, and aquatic communities of Steel Creek, species of special concern, and radiocesium in Steel Creek. Two main goals of the study were the compilation of a current inventory of the flora and fauna of the Steel Creek ecosystem and an assessment of the probable impacts of radionuclides, primarily /sup 137/Cs, that were released into Steel Creek during earlier reactor operations. Although a thorough evaluation of the impacts of the L reactor restart is impossible at this time, it is concluded that the effects on the Steel Creek ecosystem will be substantial if no mitigative measures are taken. (JGB)

  11. Evaluation of dredged material proposed for ocean disposal from Gravesend Bay Anchorage, New York

    SciTech Connect

    Barrows, E.S.; Gruendell, B.D.

    1996-09-01

    The Gravesend Bay Anchorage was one of seven waterways that the US Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in February 1994. Sediment samples were submitted for physical and chemical analyses to provide baseline sediment chemistry data on the Gravesend Bay Anchorage. Individual sediment core samples collected at the Gravesend Bay Anchorage were analyzed for grain size, moisture content, and total organic carbon (TOC). Two samples, one of composited sediment cores representing the southeast corner of the anchorage (COMP GR), and one sediment core representing the northeast corner of the anchorage (Station GR-1 0), were analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4-dichlorobenzene.

  12. Quantitative evaluation of prion inactivation comparing steam sterilization and chemical sterilants: proposed method for test standardization.

    PubMed

    Vadrot, C; Darbord, J-C

    2006-10-01

    Prions are notoriously resistant to inactivation. To prevent accidental transmission of variant Creutzfeldt-Jakob disease (vCJD), various decontamination procedures have been adopted for re-usable medical devices by the authorities of countries at risk. As the vCJD agent in humans has a wide tissue distribution, practical methods of prion decontamination urgently need to be standardized, as do other sterilization and disinfection procedures (European Committee for Standardization). This article proposes a method using a quantitative murine model, combining observations of the decrease in the infection rate, the increase in the incubation period and a simultaneously performed chemical protein fixation control. In terms of practical application, autoclaving at 134 degrees C for 18 min or 121 degrees C for 30 min, and 1N sodium hydroxide for 15 min reduced the transmission of infectivity by a factor of at least 10(6). Partial efficacy can also be identified by the methodology, particularly for liquid cold sterilants such as glutaraldehyde and peracetic acid solutions.

  13. A lightweight security scheme for wireless body area networks: design, energy evaluation and proposed microprocessor design.

    PubMed

    Selimis, Georgios; Huang, Li; Massé, Fabien; Tsekoura, Ioanna; Ashouei, Maryam; Catthoor, Francky; Huisken, Jos; Stuyt, Jan; Dolmans, Guido; Penders, Julien; De Groot, Harmke

    2011-10-01

    In order for wireless body area networks to meet widespread adoption, a number of security implications must be explored to promote and maintain fundamental medical ethical principles and social expectations. As a result, integration of security functionality to sensor nodes is required. Integrating security functionality to a wireless sensor node increases the size of the stored software program in program memory, the required time that the sensor's microprocessor needs to process the data and the wireless network traffic which is exchanged among sensors. This security overhead has dominant impact on the energy dissipation which is strongly related to the lifetime of the sensor, a critical aspect in wireless sensor network (WSN) technology. Strict definition of the security functionality, complete hardware model (microprocessor and radio), WBAN topology and the structure of the medium access control (MAC) frame are required for an accurate estimation of the energy that security introduces into the WBAN. In this work, we define a lightweight security scheme for WBAN, we estimate the additional energy consumption that the security scheme introduces to WBAN based on commercial available off-the-shelf hardware components (microprocessor and radio), the network topology and the MAC frame. Furthermore, we propose a new microcontroller design in order to reduce the energy consumption of the system. Experimental results and comparisons with other works are given.

  14. Analytical and experimental evaluation of a proposed self-forging fragment munition

    SciTech Connect

    Tuft, D.B.; Folsom, E.N.

    1982-12-27

    Analytical and experimental tools have been used to study the formation of a proposed self-forging fragment projectile. The primary objective of this study is the determination of the interior and exterior shape of the fully formed fragment, and to determine if the fragment tumbles in flight. In addition, it is of interest to compare computer predictions to experimental results. An experiment was performed using high speed photography and high-energy flash x-ray radiography to study liner and case motion and projectile formation. Fabrication and assembly tolerances were closely controlled in an effort to eliminate tolerances as a possible source of fragment instability. X-ray film-density contours were analyzed to determine the fully formed fragment interior and exterior shape. Down-range yaw screens showed fragment tumbling in flight. The computed fragment shape was compared to experimental results and it was found that a retaining ring in the computational model near the liner periphery had a significant effect on the final computed fragment shape. With the retaining ring in the computational model and full two-way sliding between all material interfaces, the final computed fragment showed very good agreement with the experiment on both exterior and interior shapes.

  15. Safety evaluations under the proposed US Safe Cosmetics and Personal Care Products Act of 2013: animal use and cost estimates.

    PubMed

    Knight, Jean; Rovida, Costanca

    2014-01-01

    The proposed Safe Cosmetics and Personal Care Products Act of 2013 calls for a new evaluation program for cosmetic ingredients in the US, with the new assessments initially dependent on expanded animal testing. This paper considers possible testing scenarios under the proposed Act and estimates the number of test animals and cost under each scenario. It focuses on the impact for the first 10 years of testing, the period of greatest impact on animals and costs. The analysis suggests the first 10 years of testing under the Act could evaluate, at most, about 50% of ingredients used in cosmetics. Testing during this period would cost about $ 1.7-$ 9 billion and 1-11.5 million animals. By test year 10, alternative, high-throughput test methods under development are expected to be available, replacing animal testing and allowing rapid evaluation of all ingredients. Given the high cost in dollars and animal lives of the first 10 years for only about half of ingredients, a better choice may be to accelerate development of high-throughput methods. This would allow evaluation of 100% of cosmetic ingredients before year 10 at lower cost and without animal testing.

  16. Evaluation of intestinal biopsies for pediatric enteropathy: a proposed immunohistochemical panel approach.

    PubMed

    Martin, Brock A; Kerner, John A; Hazard, Florette K; Longacre, Teri A

    2014-10-01

    Congenital enteropathies are rare disorders with significant clinical consequences; however, definitive diagnosis based on morphologic assessment of duodenal biopsies with routine stains alone is often impossible. To determine the role of immunohistochemistry (IHC) in the evaluation for microvillous inclusion disease, congenital tufting enteropathy (intestinal epithelial dysplasia), and enteroendocrine cell dysgenesis, a series of duodenal biopsies from 26 pediatric patients with chronic/intractable diarrhea was retrospectively reviewed. IHC stains for CD10, EpCAM, chromogranin, and villin were performed on all biopsies, and the results were correlated with hematoxylin and eosin and ultrastructural findings using electron microscopy, when available. Biopsies from 2 patients diagnosed with microvillous inclusion disease at the time of original biopsy demonstrated diffuse CD10-positive cytoplasmic inclusions within enterocytes and normal expression of EpCAM and chromogranin. Biopsies from 3 patients, including 2 siblings with confirmed EPCAM mutations, demonstrated complete loss of EpCAM expression and normal expression of CD10 and chromogranin; electron microscopic evaluation revealed characteristic ultrastructural findings of tufting enteropathy. Biopsies from 1 patient with a confirmed NEUROG3 mutation demonstrated an absence of intestinal enteroendocrine cells by chromogranin staining, consistent with enteroendocrine cell dysgenesis. Four patients' biopsies displayed nonspecific staining patterns for CD10 and/or EpCAM with normal expression of chromogranin, and 16 patients' biopsies exhibited normal expression for all 3 markers. Villin stains demonstrated heterogenous brush border labeling with nonspecific cytoplasmic reactivity, a pattern variably present throughout the biopsy series. In conclusion, the routine use of an IHC panel of CD10, EpCAM, and chromogranin is warranted in patients meeting specific age and/or clinical criteria, as the morphologic findings

  17. Programming for articularion modification.

    PubMed

    Gerber, A

    1977-02-01

    Within the past decade, principles and techniques of programmed instruction have been applied to the procedures of articulation modification in a number of preconstructed programs. The analysis of nine of these programs reveals that the majority of them are characterized by precisely stated objectives, ordered sequences of materials and procedures, clearly established criteria and rigorously controlled methods of reinforcement and recording of responses. Evaluation of the preconstructed programs raises some questions about the appropriateness of certain aspects of the technology to the process of articulation modification.

  18. Evaluation of Proposed Solutions to Global Warming, Air Pollution, and Energy Security

    NASA Astrophysics Data System (ADS)

    Jacobson, M. Z.

    2008-12-01

    This study reviews and ranks major proposed solutions to global warming, air pollution mortality, and energy security while considering other impacts of the proposed solutions, such as on water supply, land use, wildlife, resource availability, thermal pollution, water chemical pollution, nuclear proliferation, and undernutrition. Nine electric power sources and two liquid fuel options are considered. The electricity sources include solar-photovoltaics (PV), concentrated solar power (CSP), wind, geothermal, hydroelectric, wave, tidal, nuclear, and coal with carbon capture and storage (CCS) technology. The liquid fuel options include corn-E85 and cellulosic E85. To place the electric and liquid fuel sources on an equal footing, we examine their comparative abilities to address the problems mentioned by powering new-technology vehicles, including battery-electric vehicles (BEVs), hydrogen fuel cell vehicles (HFCVs), and flex-fuel vehicles run on E85. Twelve combinations of energy source-vehicle type are considered. Upon ranking and weighting each combination with respect to each of 11 impact categories, four clear divisions of ranking, or tiers, emerge. Tier 1 (highest-ranked) includes wind-BEVs and wind-HFCVs. Tier 2 includes CSP-BEVs, geothermal-BEVs, PV-BEVs, tidal-BEVs, and wave-BEVs. Tier 3 includes hydro-BEVs, nuclear-BEVs, and CCS-BEVs. Tier 4 includes corn- and cellulosic-E85. Wind-BEVs ranked first in six out of 11 categories, including the two most important, mortality and climate damage reduction. Although HFCVs are less efficient than BEVs, wind- HFCVs ranked second among all combinations. Tier 2 options provide significant benefits and are recommended. Tier 3 options are less desirable. However, hydroelectricity, which was ranked ahead of coal- CCS and nuclear with respect to climate and health, is an excellent load balancer, thus strongly recommended. The Tier-4 combinations (cellulosic- and corn-E85) were ranked lowest overall and with respect to

  19. Carbonado: Physical and chemical properties, a critical evaluation of proposed origins, and a revised genetic model

    NASA Astrophysics Data System (ADS)

    Haggerty, Stephen E.

    2014-03-01

    Carbonado-diamond is the most controversial of all diamond types and is found only in Brazil, and the Central African Republic (Bangui). Neither an affinity to Earth's mantle, nor an origin in the crust can be unequivocally established. Carbonado-diamond is at least 3.8 Ga old, an age about 0.5 Ga older than the oldest diamonds yet reported in kimberlites and lamproites on Earth. Derived from Neo- to Mid-Proterozoic meta-conglomerates, the primary magmatic host rock has not been identified. Discovered in 1841, the material is polycrystalline, robust and coke-like, and is best described as a strongly bonded micro-diamond ceramic. It is characteristically porous, which precludes an origin at high pressures and high temperatures in Earth's deep interior, yet it is also typically patinated, with a glass-like surface that resembles melting. With exotic inclusions of highly reduced metals, carbides, and nitrides the origin of carbonado-diamond is made even more challenging. But the challenge is important because a new diamondiferous host rock may be involved, and the development of a new physical process for generating diamond is possibly assured. The combination of micro-crystals and random crystal orientation leads to extreme mechanical toughness, and a predicable super-hardness. The physical and chemical properties of carbonado are described with a view to the development of a mimetic strategy to synthesize carbonado and to duplicate its extreme toughness and super-hardness. Textural variations are described with an emphasis on melt-like surface features, not previously discussed in the literature, but having a very clear bearing on the history and genesis of carbonado. Selected physical properties are presented and the proposed origins, diverse in character and imaginatively novel, are critically reviewed. From our present knowledge of the dynamic Earth, all indications are that carbonado is unlikely to be of terrestrial origin. A revised model for the origin of

  20. In situ clay formation : evaluation of a proposed new technology for stable containment barriers.

    SciTech Connect

    Nagy, Kathryn L.; DiGiovanni, Anthony Albert; Fredrich, Joanne T.

    2004-03-01

    Containment of chemical wastes in near-surface and repository environments is accomplished by designing engineered barriers to fluid flow. Containment barrier technologies such as clay liners, soil/bentonite slurry walls, soil/plastic walls, artificially grouted sediments and soils, and colloidal gelling materials are intended to stop fluid transport and prevent plume migration. However, despite their effectiveness in the short-term, all of these barriers exhibit geochemical or geomechanical instability over the long-term resulting in degradation of the barrier and its ability to contain waste. No technologically practical or economically affordable technologies or methods exist at present for accomplishing total remediation, contaminant removal, or destruction-degradation in situ. A new type of containment barrier with a potentially broad range of environmental stability and longevity could result in significant cost-savings. This report documents a research program designed to establish the viability of a proposed new type of containment barrier derived from in situ precipitation of clays in the pore space of contaminated soils or sediments. The concept builds upon technologies that exist for colloidal or gel stabilization. Clays have the advantages of being geologically compatible with the near-surface environment and naturally sorptive for a range of contaminants, and further, the precipitation of clays could result in reduced permeability and hydraulic conductivity, and increased mechanical stability through cementation of soil particles. While limited success was achieved under certain controlled laboratory conditions, the results did not warrant continuation to the field stage for multiple reasons, and the research program was thus concluded with Phase 2.