Science.gov

Sample records for modification proposal evaluation

  1. Evaluation of proposed panel closure modifications at WIPP

    SciTech Connect

    Allen, Lawrence E.; Silva, Matthew K.; Channell, James K.; Abel, John F.; Morgan, Dudley R.

    2001-12-31

    A key component in the design of the WIPP repository is the installation of concrete structures as panel seals in the intake and exhaust drifts after a panel has been filled with waste containers. As noted in the EPA final rule, the panel seal closure system is intended to block brine flow between the waste panels at the WIPP. On April 17, 2001, the DOE proposed seven modifications to the EPA concerning the design of the panel closure system. EPA approval of these modifications is necessary since the details of the panel design are specified in EPA’s final rule as a condition for WIPP certification. However, the EPA has not determined whether a rulemaking would be required for these proposed design modifications. On September 4, 2001, the DOE withdrew the request, noting that it would be resubmitted on a future date. The Environmental Evaluation Group (EEG) contracted with two engineers, Dr. John Abel and Dr. Rusty Morgan, to evaluate the proposed modifications. The EEG has accepted the conclusions and recommendations from these two experts: 1) replacement of Salado Mass Concrete with a generic salt-based concrete; 2) replacement of the explosion wall with a construction wall; 3) replacement of freshwater grouting with salt-based grouting; 4) option to allow surface or underground mixing; and 5) option to allow up to one year for completion of closure. The proposed modification to allow local carbonate river rock as aggregate is acceptable pending demonstration that no problems will exist in the resulting concrete. The proposed modification to give the contractor discretion in removal of steel forms is not supported. Instead, several recommendations are made to specifically reduce the number of forms left, thereby reducing potential migration pathways.

  2. Manufacturer evaluations of endograft modifications.

    PubMed

    Waninger, Matthew S; Whirley, Robert G; Smith, Louis J; Wolf, Ben S

    2013-03-01

    The motivation to modify the design of a vascular device can arise from a number of sources. Clinical experience with the unmodified device could suggest new design modifications to improve device performance or clinical outcomes. Similarly, clinical success with a device often suggests modifications that could broaden the applicability of the device to enable treatment of different or more advanced disease states. As a specific example, both of these scenarios have arisen during the last decade in the evolution of endovascular grafts for the treatment of abdominal aortic aneurysms, with modifications enabling the treatment of patients with shorter infrarenal necks, more angulated anatomy, and smaller access vessels. These modifications have been made by manufacturers and additionally by physicians who create branched and fenestrated devices. The experience to date with the use of fenestrated devices and the development of chimney, snorkel, and periscope techniques suggests that modifications to off-the-shelf devices may provide some clinical benefit. This experience provides additional motivation for manufacturers to develop devices to address the clinical needs not met with their current product lines. For manufacturers, the device development process includes an assessment of the new device design to determine the appropriate evaluation strategy to support the safety and effectiveness of the modified device. This report provides a high-level overview of the process generally followed by device manufacturers to evaluate a proposed device modification before market release, in accordance with local country regulations and recognized international standards such as the International Organization of Standardization (ISO) standards for endovascular grafts (ISO 25539 Part 1).

  3. Manufacturer evaluations of endograft modifications.

    PubMed

    Waninger, Matthew S; Whirley, Robert G; Smith, Louis J; Wolf, Ben S

    2013-03-01

    The motivation to modify the design of a vascular device can arise from a number of sources. Clinical experience with the unmodified device could suggest new design modifications to improve device performance or clinical outcomes. Similarly, clinical success with a device often suggests modifications that could broaden the applicability of the device to enable treatment of different or more advanced disease states. As a specific example, both of these scenarios have arisen during the last decade in the evolution of endovascular grafts for the treatment of abdominal aortic aneurysms, with modifications enabling the treatment of patients with shorter infrarenal necks, more angulated anatomy, and smaller access vessels. These modifications have been made by manufacturers and additionally by physicians who create branched and fenestrated devices. The experience to date with the use of fenestrated devices and the development of chimney, snorkel, and periscope techniques suggests that modifications to off-the-shelf devices may provide some clinical benefit. This experience provides additional motivation for manufacturers to develop devices to address the clinical needs not met with their current product lines. For manufacturers, the device development process includes an assessment of the new device design to determine the appropriate evaluation strategy to support the safety and effectiveness of the modified device. This report provides a high-level overview of the process generally followed by device manufacturers to evaluate a proposed device modification before market release, in accordance with local country regulations and recognized international standards such as the International Organization of Standardization (ISO) standards for endovascular grafts (ISO 25539 Part 1). PMID:23446123

  4. Proposed Modification to the Plutonium Systemic Model.

    PubMed

    Konzen, Kevin; Miller, Scott; Brey, Richard

    2015-10-01

    The currently accepted biokinetic model for plutonium distribution within the human body was recommended by the International Commission on Radiological Protection in publication 67. This model was developed from human and animal studies and behavioral knowledge acquired from other known bone-seeking radionuclides. The biokinetic model provides a mathematical means of predicting the distribution, retention, and clearance of plutonium within the human body that may be used in deriving organ, tissue, and whole body dose. This work proposed a modification to the ICRP 67 systemic model for plutonium that incorporated the latest knowledge acquired from recent human injection studies with physiologically based improvements. In summary, the changes included a separation of the liver compartments, removed the intermediate soft tissue-to-bladder pathway, and added pathways from the blood compartment to both the cortical and trabecular bone volumes. The proposed model provided improved predictions for several bioassay indicators compared to the ICRP 67 model while also maintaining its basic structure. Additionally, the proposed model incorporated physiologically based improvements for the liver and skeleton and continued to ensure efficient coupling with intake biokinetic models.

  5. How to use the new DSM-5 somatic symptom disorder diagnosis in research and practice: a critical evaluation and a proposal for modifications.

    PubMed

    Rief, Winfried; Martin, Alexandra

    2014-01-01

    The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) changed the term "somatoform disorders" to "somatic symptom and related disorders" and further modified diagnostic labels and criteria. We review evidence for the validity of the new criteria, specifically of somatic symptom disorder (SSD), and present a critical discussion of unsolved and new problems. We also provide an update of mechanisms and interventions that have been empirically evaluated in somatoform disorders. For many mechanisms, it is unclear whether their role can be easily transposed to SSD. Therefore more research is needed on the similarities and differences between medically unexplained and medically explained conditions. To overcome the obvious shortcomings of the current classification, we offer a modification of this DSM-5 section as well as a crossover system to apply these criteria for somatic symptom and related disorders. This proposal allows working with DSM-5 but also continuing successful lines of research with concepts such as hypochondriasis/illness anxiety, chronic pain, and medically unexplained versus medically explained syndromes.

  6. Electric utility engineer`s FGD manual -- Volume 2: Major mechanical equipment; FGD proposal evaluations; Use of FGDPRISM in FGD system modification, proposal, evaluation, and design; FGD system case study. Final report

    SciTech Connect

    1996-03-04

    Part 2 of this manual provides the electric utility engineer with detailed technical information on some of the major mechanical equipment used in the FGD system. The objectives of Part 2 are the following: to provide the electric utility engineer with information on equipment that may be unfamiliar to him, including ball mills, vacuum filters, and mist eliminators; and to identify the unique technique considerations imposed by an FGD system on more familiar electric utility equipment such as fans, gas dampers, piping, valves, and pumps. Part 3 provides an overview of the recommended procedures for evaluating proposals received from FGD system vendors. The objectives are to provide procedures for evaluating the technical aspects of proposals, and to provide procedures for determining the total costs of proposals considering both initial capital costs and annual operating and maintenance costs. The primary objective of Part 4 of this manual is to provide the utility engineer who has a special interest in the capabilities of FGDPRISM [Flue Gas Desulfurization PRocess Integration and Simulation Model] with more detailed discussions of its uses, requirements, and limitations. Part 5 is a case study in using this manual in the preparation of a purchase specification and in the evaluation of proposals received from vendors. The objectives are to demonstrate how the information contained in Parts 1 and 2 can be used to improve the technical content of an FGD system purchase specification; to demonstrate how the techniques presented in Part 3 can be used to evaluate proposals received in response to the purchase specification; and to illustrate how the FGDPRISM computer program can be used to establish design parameters for the specification and evaluate vendor designs.

  7. Project Proposals Evaluation

    NASA Astrophysics Data System (ADS)

    Encheva, Sylvia; Tumin, Sharil

    2009-08-01

    Collaboration among various firms has been traditionally used trough single project joint ventures for bonding purposes. Eventhough the performed work is usually beneficial to some extend to all participants, the type of collaboration option to be adapted is strongly influenced by overall purposes and goals that can be achieved. In order to facilitate a choice of collaboration option best suited to a firm's need a computer based model is proposed.

  8. Modified Kriging: evaluation, modification, and recommendations

    SciTech Connect

    Schultz, C.A.; Myers, S.C.

    1997-09-01

    This report describes modifications to a technique developed by Sandia National Laboratory (SNL) to predict general corrections (traveltime, etc.) for a geographic grid only sparsely covered by calibration points (Hipp and Young, 1997). SNL has worked to create a modified version of linear prediction (kriging) based on the idea of blending the surface back to zero at some distance from the points or, in other words, by damping the solution through the damping of the input data points. LLNL has been working with SNL to evaluate Modified Kriging. This report documents our evaluation of the technique and our resulting recommendations to SNL.

  9. Major Modification Determination Process Utilized for Proposed Idaho National Laboratory Projects

    SciTech Connect

    Michael A. Lehto, Ph.D.; Boyd D. Christensen

    2008-05-01

    Over the past three years, several new projects with the potential for major modifications to existing facilities have been considered for implementation at the Idaho National Laboratory (INL). These projects were designated to take place in existing nuclear facilities with existing documented safety analyses. 10 CFR 830.206 requires the contractor for a major modification to a Hazard Category 1, 2, or 3 nuclear facility to obtain Department of Energy (DOE) approval for the nuclear facility design criteria to be used for preparation of a preliminary documented safety analysis (PDSA), as well as creation and approval of the PDSA, before the contractor can procure materials or components or begin construction on the project. Given the significant effort and expense of preparation and approval of a PDSA, a major modification determination for new projects is warranted to determine if the rigorous requirements of a major modification are actually required. Furthermore, performing a major modification determination helps to ensure that important safety aspects of a project are appropriately considered prior to modification construction or equipment procurement. The projects considered for major modification status at the INL included: treatment and packaging of unirradiated, sodium-bonded highly enriched uranium (HEU) fuel and miscellaneous casting scrap in the Materials and Fuels Complex (MFC) Fuel Manufacturing Facility (FMF); post irradiation examination of Advance Fuel Cycle Initiative (AFCI) fuel in the MFC Analytical Laboratory (AL); the Advanced Test Reactor (ATR) gas test loop (GTL); and the hydraulic shuttle irradiation system (HSIS) at ATR. The major modification determinations for three of the proposed projects resulted in a negative major modification. On the other hand, the major modification determination for the GTL project concluded that the project would require a major modification. This paper discusses the process, methods, and considerations used by

  10. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 315.208 Submission, modification, revision, and withdrawal...

  11. 48 CFR 415.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Proposal evaluation. 415... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 415.305 Proposal evaluation. HCAs... of the technical evaluation team....

  12. 48 CFR 1315.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 1315... AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1315.305 Proposal evaluation. At the... evaluation team....

  13. 48 CFR 415.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Proposal evaluation. 415... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 415.305 Proposal evaluation. HCAs... of the technical evaluation team....

  14. 48 CFR 415.305 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Proposal evaluation. 415... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 415.305 Proposal evaluation. HCAs... of the technical evaluation team....

  15. 48 CFR 415.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Proposal evaluation. 415... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 415.305 Proposal evaluation. HCAs... of the technical evaluation team....

  16. 48 CFR 2415.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Proposal evaluation. 2415... Proposal evaluation. (a) After receipt of proposals, the Contracting Officer will forward copies of the... each proposal shall be retained by the Contracting Officer pending initial technical evaluation by...

  17. 48 CFR 2415.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 2415... Proposal evaluation. (a) After receipt of proposals, the Contracting Officer will forward copies of the... each proposal shall be retained by the Contracting Officer pending initial technical evaluation by...

  18. 48 CFR 215.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Proposal evaluation. 215....305 Proposal evaluation. (a)(2) Past performance evaluation. When a past performance evaluation is... Business Concerns, the evaluation factors shall include the past performance of offerors in complying...

  19. [Gardnerella vaginalis biotypes: modification of a proposed system].

    PubMed

    Pedraza-Avilés, A G; Inzunza-Montiel, A E; Ortíz-Zaragoza, M C; Morales-Espinosa, M R; Ponce-Rosas, E R

    1995-01-01

    A modified scheme is proposed for biotyping Gardnerella vaginalis based on detection of hippurate hydrolysis, beta-galactosidase (ONPG) and lipase, and fermentation of arabinose, galactose and xylose. Thirty three biotypes were found among 140 strains from women with and without bacterial vaginosis (non-specific vaginitis). The distribution of biotypes were found to be significantly different, being more predominant the biotypes 1A; 5G; 7A; 7D and 7G in women with vaginosis and the biotypes 5G and 6H in women without vaginosis. These data suggest that some biotypes of Gardnerella vaginalis are associated with bacterial vaginosis.

  20. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 715... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 715.305 Proposal evaluation... Performance System to evaluate past performance. (Access to the system by USAID contracting office...

  1. 48 CFR 215.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....305 Proposal evaluation. (a)(2) Past performance evaluation. When a past performance evaluation is... Business Concerns, the evaluation factors shall include the past performance of offerors in complying with requirements of that clause. When a past performance evaluation is required by FAR 15.304, and the...

  2. 76 FR 18723 - Proposed Information Collection; Comment Request; Weather Modification Activities Reports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Proposed Information Collection; Comment Request; Weather... requires that persons who engage in weather modification activities (e.g., cloud seeding) provide...

  3. 48 CFR 1815.208 - Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., revision, and withdrawal of proposals. (NASA supplements paragraph (b)) 1815.208 Section 1815.208 Federal... Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b)) (b) The FAR late proposal criteria do not apply to Announcements of Opportunity, NASA Research Announcements,...

  4. 48 CFR 1815.208 - Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., revision, and withdrawal of proposals. (NASA supplements paragraph (b)) 1815.208 Section 1815.208 Federal... Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b)) (b) The FAR late proposal criteria do not apply to Announcements of Opportunity, NASA Research Announcements,...

  5. 48 CFR 1815.208 - Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., revision, and withdrawal of proposals. (NASA supplements paragraph (b)) 1815.208 Section 1815.208 Federal... Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b)) (b) The FAR late proposal criteria do not apply to Announcements of Opportunity, NASA Research Announcements,...

  6. 48 CFR 1815.208 - Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., revision, and withdrawal of proposals. (NASA supplements paragraph (b)) 1815.208 Section 1815.208 Federal... Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b)) (b) The FAR late proposal criteria do not apply to Announcements of Opportunity, NASA Research Announcements,...

  7. 48 CFR 1515.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Proposal evaluation. 1515.305 Section 1515.305 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY... evaluation....

  8. 48 CFR 1515.305 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Proposal evaluation. 1515.305 Section 1515.305 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY... evaluation....

  9. 48 CFR 1515.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Proposal evaluation. 1515.305 Section 1515.305 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY... evaluation....

  10. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Proposal evaluation. 715.305 Section 715.305 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 715.305 Proposal evaluation. (a)(1) (2) USAID shall use the...

  11. 48 CFR 1415.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 1415.305 Section 1415.305 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1415.305 Proposal evaluation....

  12. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., approval and nondisclosure procedures as required by 48 CFR (DEAR) 915.207-70 shall be followed and a... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 915... AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation....

  13. 48 CFR 515.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... extent authorized by, and in accordance with, the procedures in 48 CFR 515.305-71. ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Proposal evaluation. 515... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 515.305 Proposal evaluation....

  14. 48 CFR 515.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... extent authorized by, and in accordance with, the procedures in 48 CFR 515.305-71. ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Proposal evaluation. 515... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 515.305 Proposal evaluation....

  15. 48 CFR 515.305 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... extent authorized by, and in accordance with, the procedures in 48 CFR 515.305-71. ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Proposal evaluation. 515... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 515.305 Proposal evaluation....

  16. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost...

  17. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost...

  18. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost...

  19. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost...

  20. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost...

  1. 48 CFR 52.214-23 - Late submissions, modifications, revisions, and withdrawals of technical proposals under two-step...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., modifications, revisions, and withdrawals of technical proposals under two-step sealed bidding. 52.214-23... Late submissions, modifications, revisions, and withdrawals of technical proposals under two-step..., Modifications, Revisions, and Withdrawals of Technical Proposals Under Two-Step Sealed Bidding (NOV 1999)...

  2. 48 CFR 52.214-23 - Late submissions, modifications, revisions, and withdrawals of technical proposals under two-step...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., modifications, revisions, and withdrawals of technical proposals under two-step sealed bidding. 52.214-23... Late submissions, modifications, revisions, and withdrawals of technical proposals under two-step..., Modifications, Revisions, and Withdrawals of Technical Proposals Under Two-Step Sealed Bidding (NOV 1999)...

  3. Evaluation of materials and design modifications for aircraft brakes

    NASA Technical Reports Server (NTRS)

    Ho, T. L.; Kennedy, F. E.; Peterson, M. B.

    1975-01-01

    A test program is described which was carried out to evaluate several proposed design modifications and several high-temperature friction materials for use in aircraft disk brakes. The evaluation program was carried out on a specially built test apparatus utilizing a disk brake and wheel half from a small het aircraft. The apparatus enabled control of brake pressure, velocity, and braking time. Tests were run under both constant and variable velocity conditions and covered a kinetic energy range similar to that encountered in aircraft brake service. The results of the design evaluation program showed that some improvement in brake performance can be realized by making design changes in the components of the brake containing friction material. The materials evaluation showed that two friction materials show potential for use in aircraft disk brakes. One of the materials is a nickel-based sintered composite, while the other is a molybdenum-based material. Both materials show much lower wear rates than conventional copper-based materials and are better able to withstand the high temperatures encountered during braking. Additional materials improvement is necessary since both materials show a significant negative slope of the friction-velocity curve at low velocities.

  4. 76 FR 78180 - Proposed Modification of Class E Airspace; Douglas, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... AZ E2 Douglas, AZ Bisbee Douglas International Airport, AZ (Lat. 31 28'08'' N., long. 109 36'14'' W... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class E Airspace; Douglas, AZ...: This action proposes to modify Class E airspace at Bisbee Douglas International Airport, Douglas,...

  5. Proposed modifications of Environmental Protection Agency Method 1601 for detection of coliphages in drinking water, with same-day fluorescence-based detection and evaluation by the performance-based measurement system and alternative test protocol validation approaches.

    PubMed

    Salter, Robert S; Durbin, Gregory W; Conklin, Ernestine; Rosen, Jeff; Clancy, Jennifer

    2010-12-01

    Coliphages are microbial indicators specified in the Ground Water Rule that can be used to monitor for potential fecal contamination of drinking water. The Total Coliform Rule specifies coliform and Escherichia coli indicators for municipal water quality testing; thus, coliphage indicator use is less common and advances in detection methodology are less frequent. Coliphages are viral structures and, compared to bacterial indicators, are more resistant to disinfection and diffuse further distances from pollution sources. Therefore, coliphage presence may serve as a better predictor of groundwater quality. This study describes Fast Phage, a 16- to 24-h presence/absence modification of U.S. Environmental Protection Agency (EPA) Method 1601 for detection of coliphages in 100 ml water. The objective of the study is to demonstrate that the somatic and male-specific coliphage modifications provide results equivalent to those of Method 1601. Five laboratories compared the modifications, featuring same-day fluorescence-based prediction, to Method 1601 by using the performance-based measurement system (PBMS) criterion. This requires a minimum 50% positive response in 10 replicates of 100-ml water samples at coliphage contamination levels of 1.3 to 1.5 PFU/100 ml. The laboratories showed that Fast Phage meets PBMS criteria with 83.5 to 92.1% correlation of the same-day rapid fluorescence-based prediction with the next-day result. Somatic coliphage PBMS data are compared to manufacturer development data that followed the EPA alternative test protocol (ATP) validation approach. Statistical analysis of the data sets indicates that PBMS utilizes fewer samples than does the ATP approach but with similar conclusions. Results support testing the coliphage modifications by using an EPA-approved national PBMS approach with collaboratively shared samples.

  6. 48 CFR 515.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Proposal evaluation. 515.305 Section 515.305 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACTING... evaluators, substitute paragraph (c) of the Acknowledgement/Agreement with the following language and...

  7. Modification and evaluation of fuel cell membranes

    NASA Astrophysics Data System (ADS)

    Nalawade, Amol Prataprao

    The primary goals of this study were modification of existing NafionRTM membranes and characterization of newly developed hydrocarbon-based membranes for high temperature fuel cell applications. Various NafionRTM/silicate nanocomposites were formulated via in situ sol-gel reactions for tetraethylorthosilicate. Different silicate composition profiles generated across membrane cross-sections were investigated by EDAX/ESEM. Composite water uptake, proton conductivity and fuel cell performance were comparable to that of unmodified Nafion RTM. Tafel analysis showed better electrode kinetics for composites having more silicate in the middle and less or no silicate at electrolyte-electrode interfaces. All composites showed reduced fuel cross-over and superior mechanical as well as chemical durability than unmodified NafionRTM. Poly(cyclohexadiene) (PCHD) materials were characterized in the interest of developing alternative low-cost proton exchange membranes. All cross-linked sulfonated (xsPCHD) membranes showed significantly higher water uptake at 80 °C and higher proton conductivity at 120 °C at all relative humidities (RH), compared to the current benchmark membrane, NafionRTM. A xsPCHD-poly(ethylene glycol) (PEG) copolymer and a xsPCHD-PEG blend surpassed the DOE target by exhibiting proton conductivities of 141.44 and 322.40 mS/cm, respectively, at 50 % RH. Although the PCHD-based PEMs exhibited thermal stability up to 150 °C, they showed poor mechanical properties which would cause poor membrane durability during fuel cell operation. Atomic force microscopy studies demonstrated nanophase separated morphology of xsPCHD having a higher degree of connectedness of hydrophilic domains in the copolymer and blends relative to the xsPCHD homopolymer. Broadband dielectric spectroscopy (BDS) was used to study sub-Tg relaxations in annealed poly(2,5-benzimidazole) (ABPBI) fuel cell precursor materials. A trend in degree of connectivity of charge migration pathways and

  8. MSAD actuator solenoid, performance evaluation and modification

    SciTech Connect

    North, G.

    1983-04-19

    A small conical-faced solenoid actuator is tested in order to develop design criteria for improved performance including increased pull sensitivity. In addition to increased pull for the normal electrical inputs, a reduction in pull response to short duration electrical noise pulses is also required. Along with dynamic testing of the solenoid, a linear circuit model is developed. This model permits calculation of the dynamic forces and currents which can be expected with various electrical inputs. The model parameters are related to the actual solenoid and allow the effects of winding density and shading rings to be evaluated.

  9. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... effectiveness of the health care system by leading to cost reductions for, or improvements in benefits from... as new services, organizations, and provider types) and information technology. (2) Specifications... additional system requirements. (3) Testing of the proposed modification. Provide an explanation, no...

  10. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... effectiveness of the health care system by leading to cost reductions for, or improvements in benefits from... as new services, organizations, and provider types) and information technology. (2) Specifications... additional system requirements. (3) Testing of the proposed modification. Provide an explanation, no...

  11. 77 FR 43183 - Proposed Modification of Class E Airspace; Wolf Point, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959...-ANM-17 Proposed Modification of Class E Airspace; Wolf Point, MT AGENCY: Federal Aviation... Class E airspace at Wolf Point, MT. Controlled airspace is necessary to accommodate aircraft...

  12. 75 FR 5704 - Proposed Modification of Jet Routes J-37 and J-55; Northeast United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... ``significant rule'' under Department of Transportation (DOT) Regulatory Policies and Procedures (44 FR 11034... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Proposed Modification of Jet Routes J-37...

  13. 75 FR 5703 - Proposed Modification of Jet Route J-3; Spokane, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a regulatory.... 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Jet Route J-3; Spokane, WA...

  14. 76 FR 56356 - Proposed Modification of Class E Airspace; Driggs, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... 71 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class E Airspace; Driggs,...

  15. 78 FR 740 - Availability of Draft Environmental Assessment for the Proposed Modification of the Bayonne...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    .... As a structure over navigable waters of the United States, the proposed bridge modification would... Community Corp, 317 Elm Street, Newark, NJ 07105 8. New York Assembly District 61, 853 Forest Avenue, Staten... in the January 17, 2008, issue of the Federal Register (73 FR 3316). Background and Purpose...

  16. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... improvement to the current standard in terms of the following principles: (i) Improve the efficiency and effectiveness of the health care system by leading to cost reductions for, or improvements in benefits...

  17. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... proposed modifications. 162.940 Section 162.940 Public Welfare Department of Health and Human Services... improvement to the current standard in terms of the following principles: (i) Improve the efficiency and effectiveness of the health care system by leading to cost reductions for, or improvements in benefits...

  18. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... improvement to the current standard in terms of the following principles: (i) Improve the efficiency and effectiveness of the health care system by leading to cost reductions for, or improvements in benefits...

  19. 48 CFR 15.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... that are withdrawn must be purged from primary and backup data storage systems after a copy is made for... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Submission, modification, revision, and withdrawal of proposals. 15.208 Section 15.208 Federal Acquisition Regulations System...

  20. 48 CFR 15.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... that are withdrawn must be purged from primary and backup data storage systems after a copy is made for... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Submission, modification, revision, and withdrawal of proposals. 15.208 Section 15.208 Federal Acquisition Regulations System...

  1. 48 CFR 15.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... that are withdrawn must be purged from primary and backup data storage systems after a copy is made for... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Submission, modification, revision, and withdrawal of proposals. 15.208 Section 15.208 Federal Acquisition Regulations System...

  2. 48 CFR 15.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... that are withdrawn must be purged from primary and backup data storage systems after a copy is made for... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Submission, modification, revision, and withdrawal of proposals. 15.208 Section 15.208 Federal Acquisition Regulations System...

  3. 76 FR 489 - Proposed Modification of the Minneapolis, MN, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Minneapolis, MN, Class B... Minneapolis, MN. The purpose of these meetings is to provide interested parties an opportunity to present...), 6040 28th Avenue, South, Minneapolis, MN 55450. (2) The meeting on Saturday, March 19, 2011, will...

  4. 48 CFR 1515.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 1515.305 Section 1515.305 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1515.305...

  5. 48 CFR 2015.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 2015.305 Section 2015.305 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection Processes and Techniques...

  6. 48 CFR 2015.305 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Proposal evaluation. 2015.305 Section 2015.305 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection Processes and Techniques...

  7. 48 CFR 2015.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Proposal evaluation. 2015.305 Section 2015.305 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection Processes and Techniques...

  8. 48 CFR 2015.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Proposal evaluation. 2015.305 Section 2015.305 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection Processes and Techniques...

  9. 48 CFR 2015.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Proposal evaluation. 2015.305 Section 2015.305 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection Processes and Techniques...

  10. 48 CFR 315.305 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Standards of Ethical Conduct for Employees of the Executive Branch (5 CFR part 2635), Supplemental Standards of Ethical Conduct for Employees of the Department of Health and Human Services (5 CFR part 5501... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Proposal evaluation....

  11. 48 CFR 315.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Standards of Ethical Conduct for Employees of the Executive Branch (5 CFR part 2635), Supplemental Standards of Ethical Conduct for Employees of the Department of Health and Human Services (5 CFR part 5501... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Proposal evaluation....

  12. 48 CFR 315.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Standards of Ethical Conduct for Employees of the Executive Branch (5 CFR part 2635), Supplemental Standards of Ethical Conduct for Employees of the Department of Health and Human Services (5 CFR part 5501... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Proposal evaluation....

  13. 48 CFR 315.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Standards of Ethical Conduct for Employees of the Executive Branch (5 CFR part 2635), Supplemental Standards of Ethical Conduct for Employees of the Department of Health and Human Services (5 CFR part 5501... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Proposal evaluation....

  14. ESF GROUND SUPPORT - PROPOSED JACKING BRACKET EVALUATION

    SciTech Connect

    Marvin D. Stine

    1996-03-28

    This calculation applies to the Constructor's design of the proposed jacking bracket for the W6 x 20 steel set. The specific features of the jacking bracket evaluated in this analysis are the shear on the bracket bolts, and the effects of the applied moment on the W6 x 20 steel set beam segment.

  15. The Evaluation of Litter Behavior Modification in a River Environment.

    ERIC Educational Resources Information Center

    Wagstaff, Mark C.; Wilson, Beth E.

    1988-01-01

    Behavior modification techniques were evaluated by observing litter collection behavior of commercial rafting groups. The number of litter pieces retrieved by treatment and control groups was significantly different. Results support the idea that verbal appeal and role modeling can be effective litter control techniques. (Author/CW)

  16. Silica aerogel threshold Cherenkov counters for the JLab Hall A spectrometers: improvements and proposed modifications

    SciTech Connect

    Luigi Lagamba; Evaristo Cisbani; S. Colilli; R. Crateri; R. De Leo; Salvatore Frullani; Franco Garibaldi; F. Giuliani; M. Gricia; Mauro Iodice; Riccardo Iommi; A. Leone; M. Lucentini; A. Mostarda; E. Nappi; Roberto Perrino; L. Pierangeli; F. Santavenere; Guido M. Urciuoli

    2001-10-01

    Recently approved experiments at Jefferson Lab Hall A require a clean kaon identification in a large electron, pion, and proton background environment. To this end, improved performance is required of the silica aerogel threshold Cherenkov counters installed in the focal plane of the two Hall A spectrometers. In this paper we propose two strategies to improve the performance of the Cherenkov counters which presently use a hydrophilic aerogel radiator, and convey Cherenkov photons towards the photomultipliers by means of mirrors with a parabolic shape in one direction and flat in the other. The first strategy is aerogel baking. In the second strategy we propose a modification of the counter geometry by replacing the mirrors with a planar diffusing surface and by displacing in a different way the photomultipliers. Tests at CERN with a 5GeV/c multiparticle beam revealed that both the strategies are able to increase significantly the number of the detected Cherenkov photons and, therefore, the detector performance.

  17. 77 FR 64126 - Notice of Proposed Withdrawal of Public Land for the Buffalo Bill Dam and Reservoir Modification...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... Bureau of Land Management Notice of Proposed Withdrawal of Public Land for the Buffalo Bill Dam and... recreational facilities constructed in connection with the Buffalo Bill Dam and Reservoir Modification Project... recreation site in the Buffalo Bill Dam and Reservoir Modification Project area: Sixth Principal Meridian...

  18. Proposed modifications to the Lower Mokelumne River Project, California: FERC Project No. 2916-004. Final environmental impact statement

    SciTech Connect

    Not Available

    1993-11-01

    This final environmental impact statement (FEIS) has been prepared for the Federal Energy Regulatory Commission (Commission) to consider modifications to the existing Lower Mokelumne River Project (LMRP) (FERC Project No. 2916-004) in California. Chinook salmon and steelhead trout populations in the lower Mokelumne River have experienced recent declines and fish kills associated, in part, with discharges from Camanche Dam. The California Department of Fish and Game and the California Sportfishing Protection Alliance have asked the Commission to investigate and correct these problems. A wide range of different mitigation actions has been proposed by parties participating in the scoping of this proceeding, and staff has evaluated these proposed actions in this assessment. The staff is recommending a combination of flow and non-flow modifications to the existing license, including new minimum flow and minimum pool elevation requirements at Camanche Reservoir, ramping rates on dam releases, interim attraction and out-migrant spike flows, instream habitat improvements, and a series of studies and monitoring to determine feasible means for solving off-site fish passage problems.

  19. Environmental Assessment for the proposed modification and continued operation of the DIII-D facility

    SciTech Connect

    1995-07-01

    The EA evaluates the proposed action of modifying the DIII-D fusion facility and conducting related research activities at the GA San Diego site over 1995-1999 under DOE contract number DE-ACO3-89ER51114. The proposed action is need to advance magnetic fusion research for future generation fusion devices such as ITER and TPX. It was determined that the proposed action is not a major action significantly affecting the quality of the human environment according to NEPA; therefore a finding of no significant impact is made and an environmental impact statement is not required.

  20. Oxyresveratrol: Structural Modification and Evaluation of Biological Activities.

    PubMed

    Chatsumpun, Nutputsorn; Chuanasa, Taksina; Sritularak, Boonchoo; Lipipun, Vimolmas; Jongbunprasert, Vichien; Ruchirawat, Somsak; Ploypradith, Poonsakdi; Likhitwitayawuid, Kittisak

    2016-01-01

    Oxyresveratrol (2,4,3',5'-tetrahydroxystilbene, 1), a phytoalexin present in large amounts in the heartwood of Artocarpus lacucha Buch.-Ham., has been reported to possess a wide variety of biological activities. As part of our continuing studies on the structural modification of oxyresveratrol, a library of twenty-six compounds was prepared via O-alkylation, aromatic halogenation, and electrophilic aromatic substitution. The two aromatic rings of the stilbene system of 1 can be chemically modulated by exploiting different protecting groups. Such a strategy allows for selective and exclusive modifications on either ring A or ring B. All compounds were evaluated in vitro for a panel of biological activities, including free radical scavenging activity, DNA protective properties, antiherpetic activity, inhibition of α-glucosidase and neuraminidase, and cytotoxicity against some cancer cell lines. Several derivatives were comparably active or even more potent than the parent oxyresveratrol and/or the appropriate positive controls. The partially etherified analogs 5'-hydroxy-2,3',4-trimethoxystilbene and 3',5'-dihydroxy-2,4-dimethoxystilbene demonstrated promising anti-herpetic and DNA protective activities, offering new leads for neuropreventive agent research, whereas 5'-hydroxy-2,3',4,-triisopropoxystilbene displayed anti-α-glucosidase effects, providing a new lead molecule for anti-diabetic drug development. 3',5'-Diacetoxy-2,4-diisopropoxystilbene showed potent and selective cytotoxicity against HeLa cancer cells, but the compound still needs further in vivo investigation to verify its anticancer potential. PMID:27104505

  1. Oxyresveratrol: Structural Modification and Evaluation of Biological Activities.

    PubMed

    Chatsumpun, Nutputsorn; Chuanasa, Taksina; Sritularak, Boonchoo; Lipipun, Vimolmas; Jongbunprasert, Vichien; Ruchirawat, Somsak; Ploypradith, Poonsakdi; Likhitwitayawuid, Kittisak

    2016-01-01

    Oxyresveratrol (2,4,3',5'-tetrahydroxystilbene, 1), a phytoalexin present in large amounts in the heartwood of Artocarpus lacucha Buch.-Ham., has been reported to possess a wide variety of biological activities. As part of our continuing studies on the structural modification of oxyresveratrol, a library of twenty-six compounds was prepared via O-alkylation, aromatic halogenation, and electrophilic aromatic substitution. The two aromatic rings of the stilbene system of 1 can be chemically modulated by exploiting different protecting groups. Such a strategy allows for selective and exclusive modifications on either ring A or ring B. All compounds were evaluated in vitro for a panel of biological activities, including free radical scavenging activity, DNA protective properties, antiherpetic activity, inhibition of α-glucosidase and neuraminidase, and cytotoxicity against some cancer cell lines. Several derivatives were comparably active or even more potent than the parent oxyresveratrol and/or the appropriate positive controls. The partially etherified analogs 5'-hydroxy-2,3',4-trimethoxystilbene and 3',5'-dihydroxy-2,4-dimethoxystilbene demonstrated promising anti-herpetic and DNA protective activities, offering new leads for neuropreventive agent research, whereas 5'-hydroxy-2,3',4,-triisopropoxystilbene displayed anti-α-glucosidase effects, providing a new lead molecule for anti-diabetic drug development. 3',5'-Diacetoxy-2,4-diisopropoxystilbene showed potent and selective cytotoxicity against HeLa cancer cells, but the compound still needs further in vivo investigation to verify its anticancer potential.

  2. A Proposal: Modification for Instruments and Tools Used in the Science Laboratory Setting for Students with Disabilities

    ERIC Educational Resources Information Center

    Kogan, Denis

    2015-01-01

    The purpose of this action research proposal is to create a Modification of Instruments and Tools in Science (MITS) program to address the need for providing Students With Disabilities (SWDs) appropriate access to scientific tools and techniques of scientific inquiry. This proposal contains a review of literature on SWDs, differentiating…

  3. 75 FR 73983 - Proposed Modification of the Salt Lake City, UT, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Salt Lake City, UT, Class B... information from airspace users and others concerning a proposal to revise the Class B airspace area at Salt... Terminal, 397 North 2370 West, Salt Lake City, UT 84116. (3) The meeting on Thursday, February 3,...

  4. Proposed design modifications to reduce risk of operating rotary field mowers.

    PubMed

    White, K L; Wells, L G; Shearer, S A; Piercy, L R

    2000-11-01

    The primary objective of this project was to reduce risk of injury associated with operating a rotary mower driven by a tractor power take-off (PTO) by developing and evaluating design improvements and determining their economic feasibility. Researchers have concluded that alteration of machinery design has a greater impact on the reduction of accidents than safety training. Implementation of an Operator Presence Sensing System (OPSS) and removal of the PTO are the two injury-reducing, engineering modifications evaluated by this research. Hydraulic power allows this to occur by providing dynamic braking, few moving parts (removal of the PTO), and controllable power. A hydraulic circuit was developed to power the mower and to enable an OPSS. Tractor hydraulics were simulated using a hydraulic training bench. Two mower configurations were tested: 6.55 cm3 rev(-1) (0.4 in.3 rev(-1)) displacement motor with a 0.748 kg blade and 47.5 cm3 rev(-1) (2.9 in.3 rev(-1)) displacement motor with a 9.4 kg blade. A PTO-driven rotary mower was not used to test the circuit due to spatial and safety limitations of the hydraulic training bench. Results from the first mower configuration verified the concepts behind the hydraulic circuit. The second configuration verified the OPSS and indicated the applicability of the circuit to a rotary mower. PMID:11217690

  5. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... (a)(1) (2) USAID shall use the information on offerors made available from the NIH Contractor... government employee, known as a Non-Government Evaluator (NGE), is selected to serve as a member of a...

  6. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... (a)(1) (2) USAID shall use the information on offerors made available from the NIH Contractor... government employee, known as a Non-Government Evaluator (NGE), is selected to serve as a member of a...

  7. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... (a)(1) (2) USAID shall use the information on offerors made available from the NIH Contractor... government employee, known as a Non-Government Evaluator (NGE), is selected to serve as a member of a...

  8. Evaluation of Lake Modification Alternatives for Lake Sihwa, Korea

    NASA Astrophysics Data System (ADS)

    Lee, Sang-Il; Kim, Byeong-Chan; Oh, Hae-Jin

    2002-01-01

    After the construction of an embankment at the Bay of Sihwa in Korea, a lake of 56.5 km2 surface area and 330 million m3 volume was created. Because of rapid socioenvironmental changes and the lowering of water quality in Lake Sihwa, various external measures have been proposed and some of them are being implemented. In this paper, we examine two alternatives for in-lake modification: one alternative is zoning of the lake by constructing two submerged dams and the other is channeling of the lake through reclamation. Water quality modeling was conducted for both alternatives to assess their effects. Results of the modeling revealed that the reduction of the lake size through two different approaches, when accompanied with other external measures, would improve the water quality, but to different degrees. The zonation is expected to improve the freshwater quality up to the level supplying 45 million m3 of water per year for agricultural use. The quality of channeled water would be inappropriate for agricultural use, but suitable for outdoor activities such as recreation or fishing regardless of reclamation plans considered.

  9. A Proposal for Evaluating Cognition in Assertiveness

    ERIC Educational Resources Information Center

    Vagos, Paula; Pereira, Anabela

    2010-01-01

    This article presents the development process and initial psychometric features of an instrument for evaluating cognition in assertiveness. This is an essential social skill for adolescent development and seems to encompass emotional, behavioral, and cognitive aspects. The instrument was created by combining both empirical and theoretical methods…

  10. 48 CFR 315.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Standards of Ethical Conduct for Employees of the Executive Branch (5 CFR part 2635), Supplemental Standards of Ethical Conduct for Employees of the Department of Health and Human Services (5 CFR part 5501... into consideration when making the decision to use outside evaluators. (2) When a solicited...

  11. 48 CFR 252.236-7000 - Modification proposals-price breakdown.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-price breakdown. 252.236-7000 Section 252.236-7000 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.236-7000 Modification proposals—price breakdown. As prescribed in 236.570(a), use the following clause: Modification Proposals—Price Breakdown (DEC 1991) (a)...

  12. 77 FR 39470 - Proposed Information Collection; Comment Request; Modification to Gulf of Maine/Georges Bank...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...; Modification to Gulf of Maine/Georges Bank Herring Letter of Authorization AGENCY: National Oceanic and... modifications to the requirements for midwater trawl vessels issued an All Areas Limited Access Herring Permit and/or an Areas 2 and 3 Limited Access Herring Permit that fish in Northeast (NE) multispecies...

  13. 78 FR 47010 - Proposed Safety Evaluation for Plant-Specific

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... COMMISSION Proposed Safety Evaluation for Plant-Specific Technical Specifications Task Force Traveler... requesting public comment on the proposed model safety evaluation (SE) for plant- specific adoption of... ADAMS Accession Number ML13053A075. The proposed model SE for plant-specific adoption of...

  14. Effects of proposed highway embankment modifications on water-surface elevations in the lower Pearl River flood plain near Slidell, Louisiana

    USGS Publications Warehouse

    Gilbert, J.J.; Schuck-Kolben, R. E.

    1987-01-01

    Major flooding in the lower Pearl River basin in recent years has caused extensive damage to homes and highways in the area. In 1980 and 1983, Interstate Highway 10 and U.S. Highway 190 were overtopped. In 1983, the Interstate Highway 10 crossing was seriously damaged by the flood. The U.S. Geological Survey, in cooperation with the Louisiana Department of Transportation and Development, Office of Highways, used a two-dimensional finite-element surface-water flow model to evaluate the effects the proposed embankment modifications at Interstate Highway 10 and U.S. Highway 90 on the water-surface elevations in the lower Pearl River flood plain near Slidell, Louisiana. The proposed modifications that were considered for the 1983 flood are: (1) Removal of all highway embankments, the natural condition, (2) extension of the West Pearl River bridge by 1,000 feet at U.S. Highway 90, (3) construction of a new 250-foot bridge opening in the U.S. Highways 190 and 90, west of the intersection of the highways. The proposed highway bridge modifications also incorporated lowering of ground-surface elevations under the new bridges to sea level. The modification that provided the largest reduction in backwater, about 35 percent, was a new bridge in Interstate Highway 10. The modification of the West Pearl River bridge at U.S. Highway 90 and replacement of the bridge in U.S. Highway 190 provide about a 25% reduction in backwater each. For the other modification conditions that required structural modifications, maximum backwater computed on the west side of the flood plain ranges from 0.0 to 0.8 foot and on the east side from 0.0 to 0.6 foot. Results show that although backwater is greater on the west side of the flood plain than on the east side, upstream of highway embankments, backwater decreases more rapidly in the upstream direction on the west side of the flood plain than on the east side. Analysis of the proposed modifications indicates that backwater would still occur on

  15. 77 FR 71734 - Proposed Modification of the Miami, FL, Class B Airspace Area; and the Ft Lauderdale, FL, Class C...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Miami, FL, Class B Airspace... the Class B airspace at Miami, FL, and the Class C airspace at Ft Lauderdale, FL. The purpose of these..., January 28, 2013, will be held at the Wings Over Miami Air Museum, Kendall-Tamiami Executive...

  16. 78 FR 15739 - Notice of Lodging of Proposed Third Modification to Consent Decree Under the Clean Air Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Notice of Lodging of Proposed Third Modification to Consent Decree Under the Clean Air Act On February 22... Unit 4); (5) to the installation of 200 MW of renewable energy; (6) to provide the State...

  17. 77 FR 42462 - Hawaii State Plan for Occupational Safety and Health; Proposed Modification of 18(e) Plan Approval

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-19

    ... Safety and Health; Proposed Modification of 18(e) Plan Approval AGENCY: Occupational Safety and Health... federal OSHA plan approval on December 28, 1973 (39 FR 1010). The Hawaii Occupational Safety and Health... by the plan, 29 U.S.C. 667(e). Hawaii was granted final approval effective April 30, 1984 (49...

  18. Status of in-situ air stripping tests and proposed modifications: Horizontal wells AMH-1 and AMH-2 Savannah River Site

    SciTech Connect

    Kaback, D.S.; Looney, B.B.

    1989-08-01

    A project to drill and install two horizontal vapor extraction/air injection wells at the Savannah River Site (SRS), Aiken, South Carolina, was performed in September and October of 1988. The project was performed to test the feasibility of horizontal drilling technologies in shallow unconsolidated sediments. Additional study to evaluate the effectiveness of in-situ air stripping of volatile organics from the ground water and unsaturated soils is planned. This status report contains (1) a short summary of the construction details of the two horizontal wells and (2) proposed modifications to the original program plan (Kaback and Looney 1988; Looney and Kaback, 1988). The modifications include added pressure monitoring and use of an inert tracer gas (helium) to better evaluate system performance. This paper contains sections that provide information requested by the South Carolina Department Health and Environmental Control as part of the underground injection well permitting process. 3 refs., 6 figs.

  19. Evaluation criteria for commercially oriented materials processing in space proposals

    NASA Technical Reports Server (NTRS)

    Moore, W. F.; Mcdowell, J. R.

    1979-01-01

    An approach and criteria for evaluating NASA funded experiments and demonstrations which have commercial potential were developed. Methods for insuring quick initial screening of commercial proposals are presented. Recommendations are given for modifying the current evaluation approach. New criteria for evaluating commercially orientated materials processing in space (MPS) proposals are introduced. The process for selection of qualified individuals to evaluate the phases of this approach and criteria is considered and guidelines are set for its implementation.

  20. Discovering Cooperative Relationships of Chromatin Modifications in Human T Cells Based on a Proposed Closeness Measure

    PubMed Central

    Liu, Hongbo; Wu, Xueting; Zhu, Jiang; Su, Jianzhong; Wang, Fang; Cui, Ying; Zhang, Yan

    2010-01-01

    Background Eukaryotic transcription is accompanied by combinatorial chromatin modifications that serve as functional epigenetic markers. Composition of chromatin modifications specifies histone codes that regulate the associated gene. Discovering novel chromatin regulatory relationships are of general interest. Methodology/Principal Findings Based on the premise that the interaction of chromatin modifications is hypothesized to influence CpG methylation, we present a closeness measure to characterize the regulatory interactions of epigenomic features. The closeness measure is applied to genome-wide CpG methylation and histone modification datasets in human CD4+T cells to select a subset of potential features. To uncover epigenomic and genomic patterns, CpG loci are clustered into nine modules associated with distinct chromatin and genomic signatures based on terms of biological function. We then performed Bayesian network inference to uncover inherent regulatory relationships from the feature selected closeness measure profile and all nine module-specific profiles respectively. The global and module-specific network exhibits topological proximity and modularity. We found that the regulatory patterns of chromatin modifications differ significantly across modules and that distinct patterns are related to specific transcriptional levels and biological function. DNA methylation and genomic features are found to have little regulatory function. The regulatory relationships were partly validated by literature reviews. We also used partial correlation analysis in other cells to verify novel regulatory relationships. Conclusions/Significance The interactions among chromatin modifications and genomic elements characterized by a closeness measure help elucidate cooperative patterns of chromatin modification in transcriptional regulation and help decipher complex histone codes. PMID:21151929

  1. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... base. Geographical diversity of Centers will be a factor in evaluation of proposals; a proposal for a... § 290.3(e). (4) Management and financial plan. Does the proposal define a management structure and assure management personnel to carry out development and operation of an effective Center?...

  2. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... base. Geographical diversity of Centers will be a factor in evaluation of proposals; a proposal for a... § 290.3(e). (4) Management and financial plan. Does the proposal define a management structure and assure management personnel to carry out development and operation of an effective Center?...

  3. A Review of The Society for Assisted Reproductive Technology Embryo Grading System and Proposed Modification

    PubMed Central

    Hossain, Amjad; Phelps, John; Agarwal, Ashok; Sanz, Eduardo; Mahadevan, Maha

    2016-01-01

    The Society for Assisted Reproductive Technology (SART) method of embryo grad- ing is unique, simple, and widely practiced, and its use has been mandatory for SART membership programs since 2010. Developed by SART in 2006, the current embryo grading system categories, “good, fair, and poor,” are limited because they do not describe the best 1-2 embryos in the interest of keeping pace with the shift in clinical practice to be more selective and to transfer fewer embryos. This inspired us to conduct a review on the SART embryo grading system. In this retrospective study, the literature on evaluation of human embryo quality in gen- eral, and the SART method of evaluation in particular, were reviewed for the period of 2000 to 2014. A multifaceted search pertaining to methods of embryo grading and trans- fer using a combination of relevant terms [embryo, mammalian, embryo transfer, grade, grading, morphology, biomarkers, SART, and in vitro fertilization (IVF)] was performed. The inclusion and exclusion in this review were dictated by the aim and scope of the study. Two investigators independently assessed the studies and extracted information. A total of 61 articles were reviewed. Very few studies have evaluated the efficacy of the SART embryo grading method. The present study suggests the necessity for revision of the current SART grading system. The system, as it is now, lacks criteria for describing the cohort specific best embryo and thus is of limited use in single embryo transfer. The study foresees heightened descriptive efficiency of the SART system by implementing the proposed changes. Strengths and weaknesses of the SART embryo grading were identified. Ideas for selecting the best cohort-specific embryo have been discussed, which may trigger methodological improvement in SART and other embryo grading systems. PMID:27441045

  4. 75 FR 9538 - Proposed Modification of Class B Airspace; Charlotte, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ... (ARSA) (54 FR 32604). As a result of the Airspace Reclassification Final Rule (56 FR 65638), which... in 1995 (60 FR 26594). Only minor changes were made at that time. Since that modification, the...); Wilgrove Airpark, NC (8A6): Chester-Catawba Regional, SC (DCM); Lancaster County-McWhirter Field, SC...

  5. 48 CFR 1815.208 - Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... late proposal criteria do not apply to Announcements of Opportunity, NASA Research Announcements, and..., revision, and withdrawal of proposals. (NASA supplements paragraph (b)) 1815.208 Section 1815.208 Federal... TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information...

  6. Evaluation of optimum profile modification curves of profile shifted spur gears based on vibration responses

    NASA Astrophysics Data System (ADS)

    Ma, Hui; Pang, Xu; Feng, Ranjiao; Wen, Bangchun

    2016-03-01

    In this paper, a mesh stiffness model is developed for profile shifted gears with addendum modifications and tooth profile modifications (TPMs). The time-varying mesh stiffness (TVMS), load sharing factor (LSF), loaded static transmission error (LSTE) and non-loaded static transmission error (NLSTE) of a profile shifted spur gear pair with TPMs are obtained by the analytical model. The optimum profile modification curve under different amounts of TPM is determined by analyzing the LSTE first. Then, considering the effect of NLSTE, finite element (FE) model of a geared rotor system is established. The system vibration responses under different TPM curves are analyzed and the optimum modification curve is further evaluated by amplitude frequency responses. The results show that the optimum modification curve is related to the amount of TPM and modification coefficients. The comparison of the optimum profile modification curves is evaluated by LSTE and vibration responses, which shows that the optimum modification curve should be determined by evaluating the vibration response of the geared rotor system in the low mesh frequency range.

  7. 7 CFR 3406.20 - Evaluation criteria for research proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... proposals submitted: Evaluation criterion Weight (a) Significance of the problem: This criterion is used to... knowledge constituting the natural and social sciences undergirding the agricultural, natural resources, and food systems. (1) Impact—Is the problem or opportunity to be addressed by the proposed project...

  8. 48 CFR 1515.305-71 - Documentation of proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Ethics ethics provisions at 5 CFR part 2635. (c) Any information which might reveal that an offeror has... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Documentation of proposal... Documentation of proposal evaluation. In addition to the information required by FAR 15.305(a)(3), the...

  9. 48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Confidentiality of proposal evaluation. 1415.207-71 Section 1415.207-71 Federal Acquisition Regulations System DEPARTMENT OF... or content of proposals received to any other party (including supervisors) without the...

  10. 75 FR 13049 - Proposed Modification of Class B Airspace; Charlotte, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ..., SW., Washington, DC 20591; telephone: (202) 267-8783. Correction In proposed rule FR Doc. 2010-4377... (NPRM); correction. SUMMARY: This action provides the graphic chart for the proposed rule published in... first column, add the attached graphic chart before the Issue Date line. ] TP18MR10.004 Issued...

  11. 77 FR 27149 - Proposed Modification of Class E Airspace; Unalakleet, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... aircraft using a new Area Navigation (RNAV) Global Positioning System (GPS) standard instrument approach... be submitted in triplicate to the Docket Management System (see ADDRESSES section for address and... Proposed Rulemaking Distribution System, which describes the application procedure. The Proposal The FAA...

  12. 75 FR 2582 - Proposed Modification of the Atlanta, GA, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... Friday, December 4, 2009, concerning a proposal to revise Class B airspace at Atlanta, GA, (74 FR 63818... a proposal to revise Class B airspace at Atlanta, GA, (74 FR 63818). The address and phone number..., in Covington, GA, as published in the Federal Register on Friday, December 4, 2009 (74 FR 63818),...

  13. 78 FR 25406 - Proposed Modification of Class E Airspace; Twin Falls, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... Navigation (RNAV) Global Positioning System (GPS) and the Instrument Landing System (ILS) or Localizer (LOC... application procedure. The Proposal The FAA is proposing an amendment to Title 14 Code of Federal Regulations..., to accommodate aircraft using the RNAV (GPS) and the ILS or LOC standard instrument...

  14. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... (a) In making a decision whether to provide financial support, NIST shall review and evaluate all... § 290.3(e). (4) Management and financial plan. Does the proposal define a management structure and... planned continuous internal evaluation of program activities. (iv) Plans for financial...

  15. 78 FR 69787 - Proposed Modification of Class E Airspace; Sitka, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    ... INFORMATION CONTACT: Richard Roberts, Federal Aviation Administration, Operations Support Group, Western... INFORMATION: Comments Invited Interested parties are invited to participate in this proposed rulemaking by... submitted in triplicate to the Docket Management System (see ADDRESSES section for address and phone...

  16. 40 CFR 194.65 - Notice of proposed rulemaking for modification or revocation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ISOLATION PILOT PLANT'S COMPLIANCE WITH THE 40 CFR PART 191 DISPOSAL REGULATIONS Public Participation § 194... from the most recent compliance application, the Agency will publish a Notice of Proposed Rulemaking...

  17. Health insurance reform: modifications to the Health Insurance Portability and Accountability Act (HIPAA) electronic transaction standards. Proposed rule.

    PubMed

    2008-08-22

    This rule proposes to adopt updated versions of the standards for electronic transactions originally adopted in the regulations entitled, "Health Insurance Reform: Standards for Electronic Transactions," published in the Federal Register on August 17, 2000, which implemented some of the requirements of the Administrative Simplification subtitle of the Health Insurance Portability and Accountability Act of 1996 (HIPAA). These standards were modified in our rule entitled, "Health Insurance Reform: Modifications to Electronic Data Transaction Standards and Code Sets," published in the Federal Register on February 20, 2003. This rule also proposes the adoption of a transaction standard for Medicaid Pharmacy Subrogation. In addition, this rule proposes to adopt two standards for billing retail pharmacy supplies and professional services, and to clarify who the "senders" and "receivers" are in the descriptions of certain transactions. PMID:18958949

  18. 75 FR 41774 - Proposed Establishment and Modification of Class E Airspace; Deer Park, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3...; Deer Park, WA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed...

  19. 77 FR 24159 - Proposed Modification of Class E Airspace; Plentywood, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by...: This action proposes to modify Class E airspace at Plentywood Sher-Wood Airport, Plentywood,...

  20. 78 FR 2646 - Proposed Modification of Class B Airspace; Las Vegas, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... FR 65332) closed on December 26, 2012, is reopened until February 13, 2013. ADDRESSES: Send comments... beginning of your comments. You may also submit comments through the Internet at http://www.regulations.gov... particularly helpful in developing reasoned regulatory decisions on the proposal. Comments are...

  1. 78 FR 33772 - Proposed Modification of Class E Airspace; Brigham City, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... proposal contained in this action may be changed in light of comments received. All comments submitted will... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... anticipated impact is so minimal. Since this is a routine matter that will only affect air traffic...

  2. 76 FR 30300 - Proposed Modification of Class E Airspace; Glasgow, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... 71 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR... AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM)....

  3. 78 FR 38236 - Proposed Establishment, Modification and Cancellation of Air Traffic Service (ATS) Routes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... Sparta, NJ (SAX). The FAA proposes to eliminate the part of the route between Flint, MI (FNT) and SAX. A... between HELON and ACK. V-93: V-93 currently extends between Patuxent River, MD (PXT), and the United...: is a newly established route to become effective August 22, 2013 (78 FR 29615, May 21,...

  4. 77 FR 62493 - Proposed Information Collection; Comment Request; Modification Northeast Multispecies Amendment 16

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... areas via vessel monitoring system (VMS), or to receive an LOA are also proposed to be removed from this... postal service, or electronic forms submitted via the internet or vessels' vessel monitoring system (VMS... sector, 30 min; Request to transfer Annual Catch Entitlement (ACE), 5 minutes; VMS certification form,...

  5. 76 FR 46678 - Tris carbamoyl triazine; Proposed Modification of Significant New Uses

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ...)(2) of the Toxic Substances Control Act (TSCA), EPA is proposing to amend the significant new use... identification (ID) number EPA-HQ-OPPT-2011-0108, by one of the following methods: Federal eRulemaking Portal... Friday, excluding legal holidays. The telephone number of the EPA/DC Public Reading Room is (202)...

  6. Modification of layered atelocollagen: enzymatic degradation and cytotoxicity evaluation.

    PubMed

    Vizárová, K; Bakos, D; Rehákova, M; Petríkova, M; Panáková, E; Koller, J

    1995-11-01

    Two kinds of layered atelocollagen materials cross-linked with hexamethylene diisocyanate (HMDIC), starch dialdehyde and glyoxal were enzymatically treated by bacterial collagenase. Evaluating collagenase digestion assay for these material showed progressive differences, particularly in the group of samples cross-linked with HMDIC. This should offer the possibility of programmed enzymatic degradation. These materials may be toxicologically acceptable as proven by the short-term test used for cytotoxicity evaluation.

  7. Proposed modification to the specification for dry heat microbial reduction of spacecraft hardware for future US missions

    NASA Astrophysics Data System (ADS)

    James; Spry, A.; Beaudet, Robert; Schubert, Wayne

    Dry heat microbial reduction (DHMR) is the primary technique used to reduce the microbial load of spacecraft and component parts to comply with planetary protection requirements. Often, manufacturing processes involve heating flight hardware to high temperatures for purposes other than planetary protection DHMR. At present, the existing specification in NASA document NPR8020.12C, describing the process lethality on B. atrophaeus (ATCC 9372) bacterial spores, does not allow for additional planetary protection bioburden reduction credit for processing outside a narrow temperature, time and humidity window. However, recent studies (Schubert et al., COSPAR 2008) from a comprehensive multi-year laboratory research effort have generated enhanced data sets on four aspects of the current specification: time and temperature combination effects, the effect that humidity has on spore lethality, the lethality for spores with exceptionally high thermal resistance (so called "hardies"), and the extended exposure requirement for encapsulated microorganisms. This paper describes proposed modifications to the specification, based on the data set generated in the referenced study. The proposed modifications are intended to broaden the scope of the current specification while still maintaining a confident conservative interpretation of the lethality of the DHMR process on microorganisms. Potential cost and schedule benefits to future missions utilizing the revised specification will be highlighted.

  8. 76 FR 59420 - Proposed Information Collection; Alaska Guide Service Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... Fish and Wildlife Service Proposed Information Collection; Alaska Guide Service Evaluation AGENCY: Fish... Wildlife Service) will ask the Office of Management and Budget (OMB) to approve the information collection... the IC to the Service Information Collection Clearance Officer, Fish and Wildlife Service, MS...

  9. Checklist for Designing or Evaluating Inservice Education Proposals.

    ERIC Educational Resources Information Center

    Logan, Lloyd; Sachs, Judyth

    Drawing on evidence from literature on professional development of teachers in Australia, this document discusses the essential aspects of inservice education and provides a checklist, with illustrative applications, by which to design and evaluate inservice education proposals. The checklist is based on four sets of assumptions relating to…

  10. Assessment of facial form modifications in orthodontics: proposal of a modified computerized mesh diagram analysis.

    PubMed

    Ferrario, V F; Sforza, C; Dalloca, L L; DeFranco, D J

    1996-03-01

    A modified computerized mesh diagram analysis enables rapid, easy, and independent quantifications of facial size, shape, and head position. A lateral cephalometric radiograph is traced, positioned in natural head position (NHP) according to the NHP registered on a lateral photograph, and superimposed by the standard grid of rectangles determined by the patient's upper face height and face depth. The patient's tracing is compared with a reference tracing of a norm. The two tracings are registered at nasion in NHP, and the size difference of the patient's mesh rectangles from the norm is quantified by a size normalization. The shape discrepancies are evaluated by calculating relevant displacement vectors for each cephalometric landmark, and a global difference factor. This computerized method provides a rapid graphic evaluation of the patient's sagittal and vertical discrepancies and can also be applied to determine the effects of orthodontic therapy and/or growth on the skeletal and dental relationships in a single patient.

  11. [Proposal for the modification of metformin use in patients with chronic kidney disease].

    PubMed

    Balogh, Zoltán; Mátyus, János

    2012-09-30

    Metformin is the first-line, widely used oral antidiabetic agent for the management of type 2 diabetes. There is increasing evidence that metformin use results in a reduction in cardiovascular morbidity and mortality, and might have anticancer activity. An extremely rare, but potentially life-threatening adverse effect of metformin is lactic acidosis, therefore, its use is traditionally contraindicated if the glomerular filtrate rate is below 60 mL/min. However, lactic acidosis is always associated with acute events, such as hypovolemia, acute cardiorespiratory illness, severe sepsis and acute renal or hepatic failure. Furthermore, administration of insulins and conventional antihyperglycemic agents increases the risk of severe hypoglycemic events when renal function is reduced. Therefore, the magnitude of the benefit of metformin use would outweigh potential risk of lactic acidosis in moderate chronic renal disease. After reviewing the literature, the authors give a proposal for the administration of metformin, according to the calculated glomerular filtrate rate.

  12. The MSAD actuator sclenoid, performance evaluation and modification

    NASA Astrophysics Data System (ADS)

    Worth, G.

    1983-04-01

    A small conical-faced solenoid actuator is tested in order to develop design criteria for improved performance including increased pull sensitivity. In addition to increased pull for the normal electrical inputs, a reduction in pull response to short duration electrical noise pulses is also required. Along with dynamic testing of the solenoid, a linear circuit model is developed. This model permits calculation of the dynamic forces and currents which can be expected with various electrical inputs. The model parameters are related to the actual solenoid and allow the effects of winding density and shading rings to be evaluated.

  13. Preliminary Field Evaluation of Mercury Control Using Combustion Modifications

    SciTech Connect

    V. Lissianski; P. Maly; T. Marquez

    2005-01-22

    In this project EER conducted a preliminary field evaluation of the integrated approach for mercury (Hg) and NO{sub x} control. The approach enhanced the 'naturally occurring' Hg capture by fly ash through combustion optimization, increasing carbon in ash content, and lowering ESP temperature. The evaluation took place in Green Station Units 1 and 2 located near Henderson, Kentucky and operated by Western Kentucky Energy. Units 1 and 2 are equipped with cold-side ESPs and wet scrubbers. Green Station Units 1 and 2 typically fire two types of fuel: a bituminous coal and a blend of bituminous coals based on availability. Testing of Hg emissions in Unit 2 without reburning system in operation and at minimum OFA demonstrated that efficiencies of Hg reduction downstream of the ESP were 30-40%. Testing also demonstrated that OFA system operation at 22% air resulted in 10% incremental increase in Hg removal efficiency at the ESP outlet. About 80% of Hg in flue gas at ESP outlet was present in the oxidized form. Testing of Hg emissions under reburning conditions showed that Hg emissions decreased with LOI increase and ESP temperature decrease. Testing demonstrated that maximum Hg reduction downstream of ESP was 40-45% at ESP temperatures higher than 300 F and 60-80% at ESP temperatures lower than 300 F. The program objective to demonstrate 80% Hg removal at the ESP outlet has been met.

  14. PRELIMINARY FIELD EVALUATION OF MERCURY CONTROL USING COMBUSTION MODIFICATIONS

    SciTech Connect

    Vitali Lissianski; Antonio Marquez

    2004-02-19

    In this project General Electric Energy and Environmental Research Corporation conducts a preliminary field evaluation of a novel technology, referred to as Hg/NO{sub x}, that can reduce emissions of both mercury (Hg) and oxides of nitrogen (NO{sub x}) from coal-fired power plants. The evaluation takes place in Green Station Unit 2 operated by Western Kentucky Energy. Reduction of Hg and NO{sub x} emissions in Unit 2 is achieved using coal reburning. Activities during first project year (January 23, 2003--January 22, 2004) included measurements of baseline Hg emissions in Unit 2 and pilot-scale testing. Baseline testing of Hg emissions in Green Unit 2 has been completed. Two fuels were tested with OFA system operating at minimum air flow. Mercury emissions were measured at ESP inlet and outlet, and at the stack using Ontario Hydro revised method. Testing demonstrated that baseline Hg reductions at ESP outlet and stack were 30-45% and 70-80%, respectively. Pilot-scale testing demonstrated good agreement with baseline measurements in Unit 2. Testing showed that fuel composition had an effect on the efficiency of Hg absorption on fly ash. Maximum achieved Hg removal in reburning was close to 90%. Maximum achieved Hg reduction at air staging conditions was 60%. Testing also demonstrated that lowering ESP temperature improved efficiency of Hg removal.

  15. UH-60 Black Hawk engineering simulation model validation and proposed modifications

    NASA Technical Reports Server (NTRS)

    Kaplita, Thaddeus T.

    1986-01-01

    The engineering simulation model of the UH-60A Black Hawk was validated using comparisons of model time histories with flight test data and updated to improve the fidelity of the model. The flight test data, acquired by the Army Aviation Engineering Flight Activity and consisting of 90 time histories of transient responses to step and pulse control inputs and 16 sets of steady flight data, were processed and compared to corresponding model time histories and trim data by Sikorsky. The current UH-60A model was judged to provide an acceptably accurate simulation for use as an analytical tool, certain unsatisfactory areas were identified and potential approaches to produce a more representative simulation were evaluated.

  16. Motivational interviewing in dental hygiene education: curriculum modification and evaluation.

    PubMed

    Bray, Kimberly Krust; Catley, Delwyn; Voelker, Marsha A; Liston, Robin; Williams, Karen B

    2013-12-01

    Motivational interviewing (MI) is a person-centered, goal-directed method of communication for eliciting and strengthening intrinsic motivation for behavior change. Originally developed in the field of addiction therapy, MI has been increasing applied in the health professions with a growing body of successful outcomes for tobacco cessation and diabetic control, which can significantly impact oral health. MI has shown preliminary value for impacting oral behaviors that reduce early childhood caries, plaque, and gingival inflammation. While the training in and use of MI by oral health providers is emerging, full integration into dental and dental hygiene curricula has yet to be explored. Therefore, the purpose of this project was to evaluate the full implementation of MI in the classroom and clinic of a dental hygiene curriculum.

  17. H Scan/AHP advanced technology proposal evaluation process

    SciTech Connect

    Mack, S.; Valladares, M.R.S. de

    1996-10-01

    It is anticipated that a family of high value/impact projects will be funded by the Hydrogen Program to field test hydrogen technologies that are at advanced stages of development. These projects will add substantial value to the Program in several ways, by: demonstrating successful integration of multiple advanced technologies, providing critical insight on issues of larger scale equipment design, construction and operations management, yielding cost and performance data for competitive analysis, refining and deploying enhanced safety measures. These projects will be selected through a competitive proposal evaluation process. Because of the significant scope and funding levels of projects at these development phases, Program management has indicated the need for an augmented proposal evaluation strategy to ensure that supported projects are implemented by capable investigative teams and that their successful completion will optimally advance programmatic objectives. These objectives comprise a complex set of both quantitative and qualitative factors, many of which can only be estimated using expert judgment and opinion. To meet the above need, the National Renewable Energy Laboratory (NREL) and Energetics Inc. have jointly developed a proposal evaluation methodology called H Scan/AHP. The H Scan component of the process was developed by NREL. It is a two-part survey instrument that substantially augments the type and scope of information collected in a traditional proposal package. The AHP (Analytic Hierarchy Process) component was developed by Energetics. The AHP is an established decision support methodology that allows the Program decision makers to evaluate proposals relatively based on a unique set of weighted criteria that they have determined.

  18. Proposed Modifications to Engineering Design Guidelines Related to Resistivity Measurements and Spacecraft Charging

    NASA Technical Reports Server (NTRS)

    Dennison, J. R.; Swaminathan, Prasanna; Jost, Randy; Brunson, Jerilyn; Green, Nelson; Frederickson, A. Robb

    2005-01-01

    A key parameter in modeling differential spacecraft charging is the resistivity of insulating materials. This determines how charge will accumulate and redistribute across the spacecraft, as well as the time scale for charge transport and dissipation. Existing spacecraft charging guidelines recommend use of tests and imported resistivity data from handbooks that are based principally upon ASTM methods that are more applicable to classical ground conditions and designed for problems associated with power loss through the dielectric, than for how long charge can be stored on an insulator. These data have been found to underestimate charging effects by one to four orders of magnitude for spacecraft charging applications. A review is presented of methods to measure the resistive of highly insulating materials, including the electrometer-resistance method, the electrometer-constant voltage method, the voltage rate-of-change method and the charge storage method. This is based on joint experimental studies conducted at NASA Jet Propulsion Laboratory and Utah State University to investigate the charge storage method and its relation to spacecraft charging. The different methods are found to be appropriate for different resistivity ranges and for different charging circumstances. A simple physics-based model of these methods allows separation of the polarization current and dark current components from long duration measurements of resistivity over day- to month-long time scales. Model parameters are directly related to the magnitude of charge transfer and storage and the rate of charge transport. The model largely explains the observed differences in resistivity found using the different methods and provides a framework for recommendations for the appropriate test method for spacecraft materials with different resistivities and applications. The proposed changes to the existing engineering guidelines are intended to provide design engineers more appropriate methods for

  19. Evaluation of proteomic search engines for the analysis of histone modifications.

    PubMed

    Yuan, Zuo-Fei; Lin, Shu; Molden, Rosalynn C; Garcia, Benjamin A

    2014-10-01

    Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118.

  20. Evaluation of Proteomic Search Engines for the Analysis of Histone Modifications

    PubMed Central

    2015-01-01

    Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118. PMID:25167464

  1. RBME coral temperature reconstruction: An evaluation, modifications, and recommendations

    NASA Astrophysics Data System (ADS)

    Sinclair, Daniel J.

    2015-04-01

    Rayleigh-Based Multi-Element (RBME) coral temperature reconstruction (Gaetani et al., 2011) is an important new method potentially allowing accurate ocean temperatures to be reconstructed from aragonitic corals without the need for in-situ calibration. RBME is based on a mathematical model which assumes that trace element uptake into coral skeleton is mediated by (1) temperature-dependent (inorganic) partition coefficients, and (2) a temperature-dependent change in the proportion of ions in a calcifying fluid that are precipitated as CaCO3. A time-series of Sr, Mg and Ba measurements can therefore be formulated as a set of simultaneous equations allowing temperatures and model fit-parameters to be solved numerically by least-squares minimization. Here, I critically review the RBME method, focusing on assumptions underlying the mathematical model, implementation of the numerical scheme, and the accuracy of temperature reconstruction. The equations in the RBME are highly nonlinear, and their number scales with the length of the time-series. These 'high-dimensional nonlinear optimization' problems are characterized by high computational cost, and the difficulty in finding the true 'global' minimum rather than false 'local' minima. Tests show that several of the RBME equations are highly sensitive to changing parameters thereby making it difficult for minimization algorithms to search broadly in parameter space. The method is therefore exceedingly slow and has a very strong tendency to find local optima that are close to the initial guess (which must be supplied by the user) making it very prone to 'operator bias'. Here a new formulation of the RBME system is proposed that allows much faster optimization, and a much broader search of parameter space. Testing of the RBME method reveals a number of problems. Firstly, RBME can produce many solutions to a given set of Sr, Mg and Ba data that are nearly identical in their minimization function (i.e., are equally good) but

  2. Modification and performance evaluation of a mono-valve engine

    NASA Astrophysics Data System (ADS)

    Behrens, Justin W.

    A four-stroke engine utilizing one tappet valve for both the intake and exhaust gas exchange processes has been built and evaluated. The engine operates under its own power, but has a reduced power capacity than the conventional 2-valve engine. The reduction in power is traced to higher than expected amounts of exhaust gases flowing back into the intake system. Design changes to the cylinder head will fix the back flow problems, but the future capacity of mono-valve engine technology cannot be estimated. The back flow of exhaust gases increases the exhaust gas recirculation (EGR) rate and deteriorates combustion. Intake pressure data shows the mono-valve engine requires an advanced intake valve closing (IVC) time to prevent back flow of charge air. A single actuation camshaft with advanced IVC was tested in the mono-valve engine, and was found to improve exhaust scavenging at TDC and nearly eliminated all charge air back flow at IVC. The optimum IVC timing is shown to be approximately 30 crank angle degrees after BDC. The mono-valve cylinder head utilizes a rotary valve positioned above the tappet valve. The open spaces inside the rotary valveand between the rotary valve and tappet valve represent a common volume that needs to be reduced in order to reduce the base EGR rate. Multiple rotary valve configurations were tested, and the size of the common volume was found to have no effect on back flow but a direct effect on the EGR rate and engine performance. The position of the rotary valve with respect to crank angle has a direct effect on the scavenging process. Optimum scavenging occurs when the intake port is opened just after TDC.

  3. Analytical and experimental evaluation of proposed ride comfort criteria

    NASA Technical Reports Server (NTRS)

    Vinje, E. W.

    1972-01-01

    An exploratory study was conducted to evaluate the effectiveness of indices proposed by different investigators to relate vehicle vibrations to passenger comfort. The indices considered included criteria for sinusoidal vibrations, unweighted and weighted amplitude exceedance counts, the integral of the unweighted and weighted power spectral density and absorbed power. These functions were initially examined analytically to determine the manner in which they each weighed vibration amplitude and frequency. Similarities among them are noted. Index values were then computed from measured vibrations and compared with the associated comfort ratings. The data for these comparisons were obtained from ride comfort evaluations of passenger trains.

  4. Evaluation of dredged material proposed for ocean disposal from MOTBY

    SciTech Connect

    Barrows, E.S.; Mayhew, H.L.; Word, J.Q.

    1996-09-01

    The National Park Service, US Department of the Interior requested U.S. Army Corps of Engineers/New York District (USACE-NYD) to evaluate sediments around the Military Ocean Terminal (MOTBY) in Bayonne, New Jersey for unconfined ocean disposal at the Mud Dump Site. Sediment samples were collected from MOTBY. Tests and analyses were conducted on MOTBY sediment core samples. The evaluation of proposed dredged material from MOTBY included grain size and total organic carbon (TOC) analyses and one acute toxicity test with the amphipod Ampelisca abdita. In addition to this benthic toxicity test, a bioaccumulation test (28-day exposure) was conducted.

  5. Evaluation of microscopic hematuria: a critical review and proposed algorithm.

    PubMed

    Niemi, Matthew A; Cohen, Robert A

    2015-07-01

    Microscopic hematuria (MH), often discovered incidentally, has many causes, including benign processes, kidney disease, and genitourinary malignancy. The clinician, therefore, must decide how intensively to investigate the source of MH and select which tests to order and referrals to make, aiming not to overlook serious conditions while simultaneously avoiding unnecessary tests. Existing professional guidelines for the evaluation of MH are largely based on expert opinion and have weak evidence bases. Existing data demonstrate associations between isolated MH and various diseases in certain populations, and these associations serve as the basis for our proposed approach to the evaluation of MH. Various areas of ongoing uncertainty regarding the appropriate evaluation should be the basis for ongoing research. PMID:26088073

  6. Physical evaluation system to determine medical risk and indicated dental therapy modifications.

    PubMed

    McCarthy, F M; Malamed, S F

    1979-08-01

    The physical evaluation system allows the practitioner to rapidly classify each patient according to medical risk and thus to provide dental treatment comfortably and safely. The evaluation system serves as a guide to the level of dental therapy, deisions of management, and modification of treatment for the medically compromised patient. Extensive use of the ADA physical status classification system in dentistry would allow meaningful studies of morbidity and mortality that are related to various management protocols and could conceivably have an impact on insurance schedules associated with psychosedation modalities and general anethesia on an out patient basis. A physical evaluation system cannot substitute for knowledge and good judgment. Recommended categories of physical status and modification of treatment should not be considered as absolutes, but as guides. Wheras the guidelines may appear to be inflexible, they should not be considered as such. Deviation from recommendations is often justified and is expected.

  7. Quality framework proposal for Component Material Evaluation (CME) projects.

    SciTech Connect

    Christensen, Naomi G.; Arfman, John F.; Limary, Siviengxay

    2008-09-01

    This report proposes the first stage of a Quality Framework approach that can be used to evaluate and document Component Material Evaluation (CME) projects. The first stage of the Quality Framework defines two tools that will be used to evaluate a CME project. The first tool is used to decompose a CME project into its essential elements. These elements can then be evaluated for inherent quality by looking at the subelements that impact their level of quality maturity or rigor. Quality Readiness Levels (QRLs) are used to valuate project elements for inherent quality. The Framework provides guidance for the Principal Investigator (PI) and stakeholders for CME project prerequisites that help to ensure the proper level of confidence in the deliverable given its intended use. The Framework also Provides a roadmap that defined when and how the Framework tools should be applied. Use of these tools allow the Principal Investigator (PI) and stakeholders to understand what elements the project will use to execute the project, the inherent quality of the elements, which of those are critical to the project and why, and the risks associated to the project's elements.

  8. A proposal of microtomography evaluation for restoration interface gaps.

    PubMed

    Meleo, Deborah; Manzon, Licia; Pecci, Raffaella; Zuppante, Francesca; Bedini, Rossella

    2012-01-01

    Nowadays, several adhesive systems are used in dental restoration and they are evaluated by clinical research. In vitro evaluations are often made by means of traditional observation techniques (for example scanning electron microscope (SEM), while 3D cone-beam microtomography technique (3D micro-CT), that can be able to generate 3D sample images without any sample treatment during acquisition data, is going to be used a lot in the next few years. In dental cavity restored with composite, it is possible to predict the presence of gaps due to polymerization shrinkage; that is the reason this work purpose is to reveal by 3D images and measure by micro-CT analysis the voids generated applying the most used adhesive systems at the moment. By means of microtomographic analysis is proposed an aid to overcome bidimensional SEM investigation limits like random observation of sample surface, sample sectioning (to see inside it with the relative possible structural alterations induced on the same sample) and the gold sputtering treatment. For this experimental work, human crown teeth have been selected, all restored with the same composite material, using five adhesive systems. After about 48 hours each tooth has been acquired by means of Skyscan 1072 micro-CT instrument and then processed by 3D reconstruction and micro-CT analyser software. Three adhesive systems have showed 3D micro-CT images with not as much voids as expected, with a very little extent. This kind of micro-CT in vitro evaluation proposal suggests a method to observe and quantify the voids generated after polymerization shrinkage during tooth restoration. PMID:22456021

  9. Evaluating a Proposed 20% National Renewable Portfolio Standard

    SciTech Connect

    Logan, Jeffrey; Sullivan, Patrick; Short, Walter; Bird, Lori; James, Ted L.; Shah, Monisha R.

    2009-02-01

    This paper provides a preliminary analysis of the impacts of a proposed 20% national renewable portfolio standard (RPS) by 2021, which has been advanced in the U.S. Congress by Senator Jeff Bingaman of New Mexico. The paper was prepared before the America Recovery and Reinvestment Act was signed into law by President Barack Obama on February 17, 2009, and thus does not consider important changes in renewable energy (RE) policy that need to be addressed in follow-on analysis. We use NREL's Regional Energy Deployment System (ReEDS) model to evaluate the impacts of the RPS requirements on the energy sector and consider design issues associated with renewable energy certificate (REC) trading markets.

  10. Evaluation of materials proposed for use in space flight

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1981-01-01

    The primary irritancy and allergenicity of flame resistant treated cotton knit shirts proposed for use in space flight were evaluated. The knitted shirts were supplied by NASA as follows: knitted shirts with collars were made of two-ply mercerized single-knit cotton jersey. The fabric was treated with tetrakis (hydroxymethyl) phosphonium hydroxide and subsequently cured with gaseous ammonia (THPOH/NH3). The final treatment comprised adding on diammonium phosphate (DAP)/urea. The treated fabric was process scoured to remove extraneous materials, top softened and mechanically or chemically finished as required for specific needs. Diammonium phosphate is a more efficient flame inhabitant than the phosphonium; thus, the combination treatment served to impart higher resistance to ignition and sustained combustion as required by NASA test standard.

  11. Evaluating the potential effectiveness of proposed environmental justice initiatives

    SciTech Connect

    Greenfield, N.L.; Namovicz, C.R.

    1994-12-31

    Congress directed the US Environmental Protection Agency (EPA) to create the Technical Assistance Grant (TAG) program to address the concerns of these citizens and, thereby improve community relations at Superfund sites. TAGs provide funding to allow affected residents to hire independent scientific and technical consultants to help them understand the issues at the site and better participate in remedy selection. This study will not directly assess the experience of Environmental Justice sites within the Superfund program. Rather, this study examines existing data on TAGs and the applicability of an expanded TAG program in addressing expressed Environmental Justice concerns. Specifically, the study compares the characteristics of sites with TAGs to a matched control group of sites/communities without TAGs. The study establishes a rigorous statistical baseline upon which it can evaluate the marginal contribution of outreach initiatives to the needs and concerns of minority and low income communities. The results of these analyses will serve as a foundation for evaluating proposed changes in the scope and emphasis of Superfund`s community relations and Environmental Justice outreach programs.

  12. Evaluation of Gene Modification Strategies for the Development of Low-Alcohol-Wine Yeasts

    PubMed Central

    Kutyna, D. R.; Solomon, M. R.; Black, C. A.; Borneman, A.; Henschke, P. A.; Pretorius, I. S.; Chambers, P. J.

    2012-01-01

    Saccharomyces cerevisiae has evolved a highly efficient strategy for energy generation which maximizes ATP energy production from sugar. This adaptation enables efficient energy generation under anaerobic conditions and limits competition from other microorganisms by producing toxic metabolites, such as ethanol and CO2. Yeast fermentative and flavor capacity forms the biotechnological basis of a wide range of alcohol-containing beverages. Largely as a result of consumer demand for improved flavor, the alcohol content of some beverages like wine has increased. However, a global trend has recently emerged toward lowering the ethanol content of alcoholic beverages. One option for decreasing ethanol concentration is to use yeast strains able to divert some carbon away from ethanol production. In the case of wine, we have generated and evaluated a large number of gene modifications that were predicted, or known, to impact ethanol formation. Using the same yeast genetic background, 41 modifications were assessed. Enhancing glycerol production by increasing expression of the glyceraldehyde-3-phosphate dehydrogenase gene, GPD1, was the most efficient strategy to lower ethanol concentration. However, additional modifications were needed to avoid negatively affecting wine quality. Two strains carrying several stable, chromosomally integrated modifications showed significantly lower ethanol production in fermenting grape juice. Strain AWRI2531 was able to decrease ethanol concentrations from 15.6% (vol/vol) to 13.2% (vol/vol), whereas AWRI2532 lowered ethanol content from 15.6% (vol/vol) to 12% (vol/vol) in both Chardonnay and Cabernet Sauvignon juices. Both strains, however, produced high concentrations of acetaldehyde and acetoin, which negatively affect wine flavor. Further modifications of these strains allowed reduction of these metabolites. PMID:22729542

  13. 78 FR 41926 - Proposed Information Collection Request; Comment Request; Performance Evaluation Studies on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ... AGENCY Proposed Information Collection Request; Comment Request; Performance Evaluation Studies on... an information collection request (ICR), ``Performance Evaluation Studies on Wastewater Laboratories...: (i) Evaluate whether the proposed collection of information is necessary for the proper...

  14. Flight evaluation of modifications to a digital electronic engine control system in an F-15 airplane

    NASA Technical Reports Server (NTRS)

    Burcham, F. W., Jr.; Myers, L. P.; Zeller, J. R.

    1983-01-01

    The third phase of a flight evaluation of a digital electronic engine control system in an F-15 has recently been completed. It was found that digital electronic engine control software logic changes and augmentor hardware improvements resulted in significant improvements in engine operation. For intermediate to maximum power throttle transients, an increase in altitude capability of up to 8000 ft was found, and for idle to maximum transients, an increase of up to 4000 ft was found. A nozzle instability noted in earlier flight testing was investigated on a test engine at NASA Lewis Research Center, a digital electronic engine control software logic change was developed and evaluated, and no instability occurred in the Phase 3 flight evaluation. The backup control airstart modification was evaluated, and gave an improvement of airstart capability by reducing the minimum airspeed for successful airstarts by 50 to 75 knots.

  15. Evaluation of proposed ASHRAE energy audit form and procedures

    SciTech Connect

    Hay, J.C.; Sud, I. |

    1997-12-31

    The proposed energy audit form and procedures developed by ASHRAE SP-56 were tested, evaluated, and improved in ASHRAE Research Project RP-669. A trial database of building characteristics and energy use, based on the SP-56 form and procedures, was developed, tested, and revised. The goal was to establish forms and procedures to be used by experienced auditors in the auditing of a variety of buildings in the field and to develop a means of collecting, normalizing, and distributing information on commercial and institutional building energy consumption to the industry. Energy audit data from 100 buildings were transferred to the form. The form was modified based on input from the auditors and project monitors. Concurrent with the revision and testing of the form, a trial database was developed. The database uses the form as an input form and contains primarily the building, energy, and space function data from the form. Use of the form and database on a widespread basis would permit the collection and analysis of information for building owners, utilities, agencies, and energy analysis, including comparison of energy use of any individual building to the entire stock of buildings with similar size, space functions, climate, energy sources, and fuel costs.

  16. Technical evaluation of proposed Ukrainian Central Radioactive Waste Processing Facility

    SciTech Connect

    Gates, R.; Glukhov, A.; Markowski, F.

    1996-06-01

    This technical report is a comprehensive evaluation of the proposal by the Ukrainian State Committee on Nuclear Power Utilization to create a central facility for radioactive waste (not spent fuel) processing. The central facility is intended to process liquid and solid radioactive wastes generated from all of the Ukrainian nuclear power plants and the waste generated as a result of Chernobyl 1, 2 and 3 decommissioning efforts. In addition, this report provides general information on the quantity and total activity of radioactive waste in the 30-km Zone and the Sarcophagus from the Chernobyl accident. Processing options are described that may ultimately be used in the long-term disposal of selected 30-km Zone and Sarcophagus wastes. A detailed report on the issues concerning the construction of a Ukrainian Central Radioactive Waste Processing Facility (CRWPF) from the Ukrainian Scientific Research and Design institute for Industrial Technology was obtained and incorporated into this report. This report outlines various processing options, their associated costs and construction schedules, which can be applied to solving the operating and decommissioning radioactive waste management problems in Ukraine. The costs and schedules are best estimates based upon the most current US industry practice and vendor information. This report focuses primarily on the handling and processing of what is defined in the US as low-level radioactive wastes.

  17. Evaluation of Lower Umatilla River Channel Modifications Below Three Mile Dam, 1984 Annual Progress Report.

    SciTech Connect

    Nigro, Anthony A.; Ward, David L.

    1985-05-01

    This report summarizes results of the first year of a study initiated in September 1984 to evaluate the adequacy of channel modifications made in the lower Umatilla River to improve adult anadromous salmonid passage to Three Mile Dam (RKm 5.6), determine if fish passage or delay problems exist at Three Mile Dam and recommend site specific corrective measures if needed. Movements of steelhead (Salmo gairdneri) were monitored using mark and recapture and radio telemetry techniques. Thirty-four steelhead were marked with T-anchor tags and released in the lower river. Fifteen of those marked were also fitted with radio transmitters. Three radiotagged steelhead migrated through channel modifications to Three Mile Dam. Two of these fish migrated to the dam in less than 26 hours, but held just below the dam for 7 and 10 days before entering the ladders. The third steelhead delayed for 30 days and entered the west ladder within 24 hours of arrival at the dam. Two other radiotagged steelhead moved upstream through some of the channel modifications but did not migrate to the dam. Only one of 19 marked steelhead not fitted with transmitters was recovered at Three Mile Dam. 14 refs., 18 figs., 3 tabs.

  18. Technical evaluation of the CG-47201 6V-92 detroit diesel electronic control (DDEC) propulsion modification. Final report

    SciTech Connect

    Latas, R.M.

    1995-03-01

    This report describes the testing and evaluation (TE) of the CG-47201 6V-92 DDEC Propulsion Modification that was conducted at Coast Guard Station Cape May, New Jersey, during the period 8-12 November 1994.

  19. Sustainable urban housing in Kathmandu, Nepal: Proposals and evaluations

    NASA Astrophysics Data System (ADS)

    Shrestha, Vikas

    quantifies the embodied energy of basic building materials that are used in Nepal; proposes new types of locally-produced insulation; and develops a sustainable design evaluation system based on LEED. This integrated system of sustainable materials database, evaluation system, and vernacular-based housing prototypes developed in this dissertation lays out an example for other third world countries.

  20. 78 FR 5761 - Proposed Modification of Significant New Uses of Ethaneperoxoic Acid, 1,1-Dimethylpropyl Ester

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... of June 26, 1990 (55 FR 26102), EPA published a final SNUR (codified at Sec. 721.1560 and... and reference: June 26, 1990 (55 FR 26111). Basis for modification of the SNUR: The TSCA section 5(e... outlined in Unit II. of this document and in the Federal Register document of June 26, 1990 (55 FR...

  1. 76 FR 27380 - Proposed Information Collection (Report of Medical Examination for Disability Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... AFFAIRS Proposed Information Collection (Report of Medical Examination for Disability Evaluation); Comment... disability benefits. DATES: Written comments and recommendations on the proposed collection of information.... Title: Report of Medical Examination for Disability Evaluation, VA Form 21-2545. OMB Control...

  2. Proposed modifications to the RCRA post-closure permit for the Bear Creek Hydrogeologic Regime at the US Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to several conditions of the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Bear Creek Hydrogeologic Regime (BCHR). These permit conditions define the requirements for RCRA post-closure corrective action groundwater monitoring at the S-3 Ponds, the Oil Landfarm, and the Bear Creek Burial Grounds (units A, C-West, and Walk-in Pits). Modification of these PCP conditions is requested to: (1) clarify the planned integration of RCRA post-closure corrective action groundwater monitoring with the monitoring program to be established in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Record of Decision (ROD) for the Bear Creek Valley (BCV) Watershed, (2) revise several of the current technical requirements for groundwater monitoring based on implementation of the RCRA post-closure corrective action monitoring program during 1996, and (3) update applicable technical procedures with revised versions recently issued by the Y-12 Plant Groundwater Protection Program (GWPP). With these modifications, the Y-12 Plant will continue to meet the full intent of all regulatory obligations for post-closure care of these facilities. Section 2.0 provides the technical justification for each proposed permit modification. The proposed changes to permit language are provided in Section 3.0 (S-3 Ponds), Section 4.0 (Oil Landfarm), and Section 5.0 (Bear Creek Burial Grounds). Sections 6.0 and 7.0 reference updated and revised procedures for groundwater sampling, and monitoring well plugging and abandonment, respectively. Appendix A includes all proposed revisions to the PCP Attachments.

  3. 75 FR 47614 - Notice of Submission of Proposed Information Collection to OMB; Training Evaluation Form

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB; Training Evaluation... comments on the subject proposal. The Training Evaluation Form will be used by HUD to determine how.... This notice also lists the following information: Title of Proposal: Training Evaluation Form....

  4. 48 CFR 2052.215-79 - Contract award and evaluation of proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... evaluation of proposals. 2052.215-79 Section 2052.215-79 Federal Acquisition Regulations System NUCLEAR... Clauses 2052.215-79 Contract award and evaluation of proposals. As prescribed in 2015.209(a)(1), the... important than cost: Contract Award and Evaluation of Proposals (OCT 1999) (a) By use of narrative...

  5. Evaluation of exercise-respiratory system modifications and integration schemes for physiological systems

    NASA Technical Reports Server (NTRS)

    Gallagher, R. R.

    1974-01-01

    Exercise subroutine modifications are implemented in an exercise-respiratory system model yielding improvement of system response to exercise forcings. A more physiologically desirable respiratory ventilation rate in addition to an improved regulation of arterial gas tensions and cerebral blood flow is observed. A respiratory frequency expression is proposed which would be appropriate as an interfacing element of the respiratory-pulsatile cardiovascular system. Presentation of a circulatory-respiratory system integration scheme along with its computer program listing is given. The integrated system responds to exercise stimulation for both nonstressed and stressed physiological states. Other integration possibilities are discussed with respect to the respiratory, pulsatile cardiovascular, thermoregulatory, and the long-term circulatory systems.

  6. Evaluation and Modification of Cognitive Computing Model of Car Driver's Eye Movement

    NASA Astrophysics Data System (ADS)

    Mizutani, Kentaro; Saito, Genki; Omori, Takashi; Itou, Takafumi

    In a previous study, we proposed a methodology to estimate a driver's internal cognitive process by his/her eye movement and demonstrated the estimation process by a computer simulation. However, the evaluation of the proposed model in real human driving behavior still remains to be realized. In this study, we analyzed gaze movements of real drivers measured while they were using a driving simulator. The results revealed a partial discrepancy between the eye position distribution generated by the proposed model and the eye position observed in actual human behavior. We discuss on the reason of this discrepancy and improved of our model.

  7. Proposal for modifications to US Department of Transportation specification 21PF-1 fire and shock resistant phenolic foam-insulated metal overpack. [Room temperature to 1475/sup 0/F

    SciTech Connect

    Barlow, C.R.; Ziehlke, K.T.; Pryor, W.A.; Frazier, J.L.; Kellogg, D.R.; Stout, F.W.

    1988-01-01

    Slightly enriched product uranium hexafluoride (UF/sub 6/) shipped from enriching plants for the world's nuclear power plants must be protected in order to conform to domestic and international transport regulations. The principal overpack currently in use is the US Department of Transportation (DOT) Specification 21PF-1 which protects Model 30 UF/sub 6/ cylinders (Title 49, Code of Federal Regulations, Part 178.121, Specification 21PF-1; Fire and Shock Resistant, Phenolic-Foam Insulated, Metal Overpack). Operational problems developed from both design and lack of maintenance have resulted in the entry of water into the insulation. To minimize this water entry, design modifications are necessary. Proposed modifications for existing overpacks are to be made only after any water absorbed within the insulation is reduced to an acceptable level. New 21PF-1 overpacks will be fabricated under an enhanced design. In both cases, proposed quality assurance/control requirements in the fabrication, modification, use and maintenance of the overpacks are applicable to fabricators, modifiers, owners and users. The phenolic foam is the thermal barrier, which maintains the UF/sub 6/ below its triple point in the event of exposure to elevated temperatures. Evaluation of the thermal qualities of the overpack required extensive analytical modeling correlated with experimental measurement. An experimental program was devised to measure the thermal conductivity and heat capacity of the phenolic foam from room temperature to approximately 1475/sup 0/F (1073/sup 0/K).

  8. CRITERIA FOR EVALUATION OF PROPOSED PROTOZOAN DETECTION METHODS.

    EPA Science Inventory

    There has been a proliferation of techniques and methods reported for analysis of water samples to determine the presence of the protozoan pathogens Cryptosporidium parvum and Giardia lamblia. Many of the proposed methods are presented as complete procedures, which include sampli...

  9. CRITERIA FOR EVALUATION OF PROPOSED PROTOZOAN DETECTION METHODS

    EPA Science Inventory

    There has been a proliferation of techniques and methods reported for analysis of water samples to determine the presence of the protozoan pathogens Cryptosporidium parvum and Giardia lamblia. Many of the proposed methods are presented as complete procedures, which include sampli...

  10. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... business size, industry types, product mix, and technology requirements. (ii) Geographical location... NIST research results and expertise in the technical areas noted in these procedures? (3) Technology... § 290.3(e). (4) Management and financial plan. Does the proposal define a management structure...

  11. 77 FR 69539 - 30-Day Notice of Proposed Information Collection: Humphrey Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... Notice of Proposed Information Collection: Humphrey Evaluation Survey ACTION: Notice of request for... Information Collection: Humphrey Evaluation Survey. OMB Control Number: None. Type of Request: New Collection. Originating Office: Bureau of Educational and Cultural Affairs, Office of Policy and Evaluation,...

  12. 77 FR 43899 - 60-Day Notice of Proposed Information Collection: Humphrey Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... Notice of Proposed Information Collection: Humphrey Evaluation Survey ACTION: Notice of request for... accordance with the Paperwork Reduction Act of 1995. Title of Information Collection: Humphrey Evaluation.... Originating Office: Bureau of Educational and Cultural Affairs, Office of Policy and Evaluation,...

  13. 77 FR 6168 - 60-Day Notice of Proposed Information Collection: English Language Evaluation Surveys, OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Notice of Proposed Information Collection: English Language Evaluation Surveys, OMB Control Number 1405... Information Collection: English Language Evaluation: Fulbright English Teaching Assistantship (ETA) Program...: Voluntary. Title of Information Collection: English Language Evaluation: English Language Specialist...

  14. Evaluation of textiles proposed for spacecraft crew apparel

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1976-01-01

    Textiles proposed for spacecraft wearing apparel were tested for possible primary irritancy and allergenicity using guinea pigs and human subjects. The materials submitted for testing were: (1) blue, loosely knit fabric of a copolymer of chlorotrifluoroethylene and ethylene (CTFE), (2) a white fabric, 100% cotton double knit, treated with fire retardant Tetrakis (hydroxymethyl) phosphonium hydroxide/ammonia, and (3) a gold colored polyimide fabric. There were no adverse reactions to any of the fabrics.

  15. 15 CFR 400.26 - Criteria for evaluation of applications for expansions, subzones or other modifications of zones.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Criteria for evaluation of applications for expansions, subzones or other modifications of zones. 400.26 Section 400.26 Commerce and... Authority § 400.26 Criteria for evaluation of applications for expansions, subzones or other...

  16. 15 CFR 400.26 - Criteria for evaluation of applications for expansions, subzones or other modifications of zones.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Criteria for evaluation of applications for expansions, subzones or other modifications of zones. 400.26 Section 400.26 Commerce and... Authority § 400.26 Criteria for evaluation of applications for expansions, subzones or other...

  17. Synthesis and evaluation of bioorthogonal pantetheine analogues for in vivo protein modification.

    PubMed

    Meier, Jordan L; Mercer, Andrew C; Rivera, Heriberto; Burkart, Michael D

    2006-09-20

    In vivo carrier protein tagging has recently become an attractive target for the site-specific modification of fusion systems and new approaches to natural product proteomics. A detailed study of pantetheine analogues was performed in order to identify suitable partners for covalent protein labeling inside living cells. A rapid synthesis of pantothenamide analogues was developed and used to produce a panel which was evaluated for in vitro and in vivo protein labeling. Kinetic comparisons allowed the construction of a structure-activity relationship to pinpoint the linker, dye, and bioorthogonal reporter of choice for carrier protein labeling. Finally bioorthogonal pantetheine analogues were shown to target carrier proteins with high specificity in vivo and undergo chemoselective ligation to reporters in crude cell lysate. The methods demonstrated here allow carrier proteins to be visualized and isolated for the first time without the need for antibody techniques and set the stage for the future use of carrier protein fusions in chemical biology.

  18. Evaluation of Grid Modification Methods for On- and Off-Track Sonic Boom Analysis

    NASA Technical Reports Server (NTRS)

    Nayani, Sudheer N.; Campbell, Richard L.

    2013-01-01

    Grid modification methods have been under development at NASA to enable better predictions of low boom pressure signatures from supersonic aircraft. As part of this effort, two new codes, Stretched and Sheared Grid - Modified (SSG) and Boom Grid (BG), have been developed in the past year. The CFD results from these codes have been compared with ones from the earlier grid modification codes Stretched and Sheared Grid (SSGRID) and Mach Cone Aligned Prism (MCAP) and also with the available experimental results. NASA's unstructured grid suite of software TetrUSS and the automatic sourcing code AUTOSRC were used for base grid generation and flow solutions. The BG method has been evaluated on three wind tunnel models. Pressure signatures have been obtained up to two body lengths below a Gulfstream aircraft wind tunnel model. Good agreement with the wind tunnel results have been obtained for both on-track and off-track (up to 53 degrees) cases. On-track pressure signatures up to ten body lengths below a Straight Line Segmented Leading Edge (SLSLE) wind tunnel model have been extracted. Good agreement with the wind tunnel results have been obtained. Pressure signatures have been obtained at 1.5 body lengths below a Lockheed Martin aircraft wind tunnel model. Good agreement with the wind tunnel results have been obtained for both on-track and off-track (up to 40 degrees) cases. Grid sensitivity studies have been carried out to investigate any grid size related issues. Methods have been evaluated for fully turbulent, mixed laminar/turbulent and fully laminar flow conditions.

  19. Evaluating A Community College Transfer Program: A Proposal.

    ERIC Educational Resources Information Center

    McCabe, Robert H.

    Recent concern about academic quality and costs has resulted in growing criticism of the transfer function of the community college. This criticism has arisen, in part, from the evaluations of university-based researchers who have argued that a very small percentage of community college students succeed in transferring to four-year institutions…

  20. Environmental Education in Italy: Proposals for an Evaluation Strategy.

    ERIC Educational Resources Information Center

    Mayer, Michela

    1991-01-01

    The evolution of environmental education (EE) in elementary, secondary, and higher education in Italy is described, focusing on its role in curricula, trends in awareness, an international agency's research program on EE, values underlying EE, a suggested educational model, and use of an indicator system for evaluating educational quality. (MSE)

  1. Proposed resource evaluation plan. Salton Sea scientific drilling program

    SciTech Connect

    Not Available

    1985-03-01

    The report presents a plan for evaluating the deep geothermal resource in the Salton Sea area of Imperial County, California. The plan is divided into two testing programs, followed by the modeling and evaluation of the underground geothermal resource. The testing program related to geological data collection includes acquiring and analyzing the core, running geophysical and temperature/pressure logs in both the deep well and the injection well, and carrying out extensive mud-logging activities. The flow testing program includes temperature, pressure, and flow measurements made in the well and surface facilities. Sampling and analysis of fluid and scale both in the well and at the surface facilities will also be carried out. 6 refs., 7 figs., 7 tabs. (ACR)

  2. 38 CFR 16.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... research support: Evaluation of applications and proposals. 16.123 Section 16.123 Pensions, Bonuses, and... research support: Evaluation of applications and proposals. (a) The department or agency head may require... approving applications or proposals covered by this policy the department or agency head may take...

  3. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... evaluate proposals and select the best one? 51.16 Section 51.16 Parks, Forests, and Public Property... Procedures § 51.16 How will the Director evaluate proposals and select the best one? (a) The Director will apply the selection factors set forth in § 51.17 by assessing each timely proposal under each of...

  4. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... evaluate proposals and select the best one? 51.16 Section 51.16 Parks, Forests, and Public Property... Procedures § 51.16 How will the Director evaluate proposals and select the best one? (a) The Director will apply the selection factors set forth in § 51.17 by assessing each timely proposal under each of...

  5. Two-Dimensional Hydrodynamic Modeling and Analysis of the Proposed Channel Modifications and Grade Control Structure on the Blue River near Byram's Ford Industrial Park, Kansas City, Missouri

    USGS Publications Warehouse

    Huizinga, Richard J.

    2007-01-01

    The Blue River Channel Modification project being implemented by the U.S. Army Corps of Engineers (USACE) is intended to provide flood protection within the Blue River valley in the Kansas City, Mo., metropolitan area. In the latest phase of the project, concerns have arisen about preserving the Civil War historic area of Byram's Ford and the associated Big Blue Battlefield while providing flood protection for the Byram's Ford Industrial Park. In 1996, the USACE used a physical model built at the Waterways Experiment Station (WES) in Vicksburg, Miss., to examine the feasibility of a proposed grade control structure (GCS) that would be placed downstream from the historic river crossing of Byram's Ford to provide a subtle transition of flow from the natural channel to the modified channel. The U.S. Geological Survey (USGS), in cooperation with the USACE, modified an existing two-dimensional finite element surface-water model of the river between 63d Street and Blue Parkway (the 'original model'), used the modified model to simulate the existing (as of 2006) unimproved channel and the proposed channel modifications and GCS, and analyzed the results from the simulations and those from the WES physical model. Modifications were made to the original model to create a model that represents existing (2006) conditions between the north end of Swope Park immediately upstream from 63d Street and the upstream limit of channel improvement on the Blue River (the 'model of existing conditions'). The model of existing conditions was calibrated to two measured floods. The model of existing conditions also was modified to create a model that represents conditions along the same reach of the Blue River with proposed channel modifications and the proposed GCS (the 'model of proposed conditions'). The models of existing conditions and proposed conditions were used to simulate the 30-, 50-, and 100-year recurrence floods. The discharge from the calibration flood of May 15, 1990, also

  6. Ecological evaluation of proposed dredged material from Richmond Harbor

    SciTech Connect

    Pinza, M R; Ward, J A; Mayhew, H L; Word, J Q; Niyogi, D K; Kohn, N P

    1992-10-01

    During the summer of 1991, Battelle/Marine Sciences Laboratory (MSL) was contracted to conduct sampling and testing of sediments proposed for dredging of Richmond Harbor, California. The MSL collected sediment cores to a depth of [minus]40 ft MLLW ([minus]38 ft + 2 ft overdepth) from 28 (12-in. core) and 30 (4-in. core) stations. The sediment cores were allocated to six composite samples referred to as sediment treatments, which were then subjected to physical, chemical, toxicological, and bioaccumulation testing. Physical and chemical parameters included grain size, total organic carbon (TOC), total volatile solids (TVS), oil and grease, total petroleum hydrocarbons (TPH), polynuclear aromatic hydrocarbons (PAH), chlorinated pesticides, polychlorinated biphenyis (PCBs), priority pollutant metals, and butyltins. The results from the test treatments were compared to results from five reference treatments representative of potential in-bay and offshore disposal sites.

  7. Evaluation of proposed Skylab and SSP soap products.

    NASA Technical Reports Server (NTRS)

    Durfee, R. L.; Spurlock, J. M.; Whitmore, F. C.

    1973-01-01

    Four candidate cleansing agents evaluated in terms of potential hazards to crew members included two soaps (Neutrogena bar soap and Olive Leaf Liquid), one nonfoaming surfactant (Miranol JEM), and one laundry detergent (sodium dodecylbenzene sulfonate). None of the four exhibited adverse dermatological effects from skin patch tests or supported growth of potentially pathogenic microorganisms. Aqueous solutions of Neutrogena did support a mold species. Neutrogena and Miranol JEM were used in a simulated Skylab personal hygiene regimen with no adverse effects on skin or skin microflora. Based on our results, each of these agents appear to be a promising candidate material for the use intended.

  8. 75 FR 29571 - Notice of Proposed Information Collection for Public Comment; Training Evaluation Form

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-26

    ... URBAN DEVELOPMENT Notice of Proposed Information Collection for Public Comment; Training Evaluation Form... lists the following information: Title of Proposal: Training Evaluation Form. OMB Control Number: 2577... management. The Training Evaluation Form will be used by the Office of Public and Indian Housing to...

  9. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed...

  10. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed...

  11. Preliminary evaluation of a proposed injection site in Mellones

    SciTech Connect

    Ortiz, N.V.; Rada, H.M.

    1996-08-01

    A hydrogeological evaluation was carried out in the Melones area to determine the feasibility of disposing brackish water and brines associated with oil production activities. The region is located towards north-central Hamaca, in the Anzoategui state, and covers an area of approximately 454 km{sup 2}. The study was based on the examination and interpretation of available stratigraphic and structural maps, well logs and formation water analysis. Engineering properties were estimated from 42 wells, selected from a total of 575 wells, where complete sets of well logs were available. The most suitable injection interval, integrated by the 02/3, D1-D2-D3-D4 and E1-E2 sands from the upper part of the Oficina Formation, was selected by addressing certain technical requirements for suitable potential disposal sites and injection intervals. A two-dimensional finite difference flow model was used to simulate the long-term hydraulic head buildup under projected operating conditions. After examination of the important characteristics considered in the evaluation process, it appears that the Melones area favorably meets most criteria.

  12. 78 FR 35942 - Proposed Collection; Comment Request: Palliative Care: Conversations Matter Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request: Palliative Care.... Proposed Collection Palliative Care: Conversations Matter Evaluation -0925--New--National Institute of... developed Palliative Care: Conversations Matter, a pediatric palliative care campaign to address...

  13. Evaluation of Outlier Detection and Modification Methods Used in Flood Frequency Analysis

    NASA Astrophysics Data System (ADS)

    Senarath, S. U. S.

    2014-12-01

    Accurate and reliable information on flood frequency and magnitude is vital for the design of hydraulic structures and for floodplain mapping. The time-series data used for flood frequency analysis are obtained from both gauged systematic records and also historical floods. These time-series data sets, however, may include outliers. Outliers are defined as values that are much larger or smaller than most of the values in a given data set. Therefore, by definition, outliers include both very high and very low values. However, the main focus of this study is only on high outliers (hereafter referred to as simply outliers). The availability of a wide-array of tests and techniques makes the outlier detection and modification procedure anything but straightforward. The set of tests and techniques that is selected to detect and modify these outliers can have a direct impact on flood frequency and magnitude estimates. Many different approaches, based on the principles of hypothesis testing, are available for the detection of outliers. Several such methods are examined in detail in this study by using data from Southeast Europe. Outliers detected using these approaches can be eliminated, modified or disregarded (i.e., by treating them as non-outliers) prior to being used in flood frequency analyses. Eliminating or disregarding the outliers typically requires additional gauge- or event-specific information in order to be fully implemented. In the absence of such information, the practice of using modified outliers in flood frequency analysis provides the best compromise. Nevertheless, the effects of all three options on flood frequency and magnitude estimates are investigated to provide a more meaningful comparison. Flood magnitude-frequency estimates based on the log Pearson type 3 distribution are used in this study to evaluate the effect of outlier modification. The study findings have important implications for estimation of flood frequency and magnitude with time

  14. Evaluation of proposed degradation algorithms for multiburst environments

    SciTech Connect

    Olness, D.U.; Warshawsky, A.S.

    1993-03-04

    This work is part of an ongoing effort of the Defense Nuclear Agency's Intermediate Dose Program to investigate the effects of intermediate radiation doses on combat unit performance. The objective of this study is to develop an improved technique for applying performance degradation factors to combat crews in simulated battles following multiple radiation doses on the tactical battlefield. A further objective of the study is to quantify differences in Janus results when crew performance factors, following multiple radiation doses, are obtained from the improved technique instead of from the technique used previously. In this paper, the authors describe and evaluate three methods previously identified for determining performance degradation from multiple exposures. They also present the observed quantitative differences in outcomes of conventional battles begun a few hours after multiple radiation exposures when alternate techniques for calculating combat crew performance degradation factors are included in the Janus combat simulation.

  15. Evaluation of proposed degradation algorithms for multiburst environments

    SciTech Connect

    Olness, D.U.; Warshawsky, A.S.

    1993-03-04

    This work is part of an ongoing effort of the Defense Nuclear Agency`s Intermediate Dose Program to investigate the effects of intermediate radiation doses on combat unit performance. The objective of this study is to develop an improved technique for applying performance degradation factors to combat crews in simulated battles following multiple radiation doses on the tactical battlefield. A further objective of the study is to quantify differences in Janus results when crew performance factors, following multiple radiation doses, are obtained from the improved technique instead of from the technique used previously. In this paper, the authors describe and evaluate three methods previously identified for determining performance degradation from multiple exposures. They also present the observed quantitative differences in outcomes of conventional battles begun a few hours after multiple radiation exposures when alternate techniques for calculating combat crew performance degradation factors are included in the Janus combat simulation.

  16. Evaluation of proposed Skylab and SSP soap products

    NASA Technical Reports Server (NTRS)

    Whitmore, F. C.; Durfee, R. L.; Spurlock, J. M.

    1973-01-01

    Three personal hygiene cleansing agents and one laundry detergent (sodium dodecyl benzene sulfonate), which are all candidates for use on long-duration space missions, were evaluated in terms of dermatological effects on human subjects and effects on microbiological species. None of the four materials exhibited adverse dermatological effects from either skin patch tests of two weeks duration or a simulated Skylab personal hygiene regimen of up to four weeks duration. No significant alterations in skin microflora during the use regimen were found. None of the four materials were found to serve as microbiological support media for the species tested, but a species of air-borne mold was observed to grow rapidly in a neutralized aqueous solution. None of the candidate agents was found to be strongly biocidal.

  17. Evaluation of materials proposed for use in space flight

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1981-01-01

    The cutaneous primary irritancy and allergenicity potential of cotton shirts/fabrics treated with flame retardants were evaluated in order to establish their suitability for spacecraft crew use. Twenty-five volunteer human subjects were patch tested on the back utilizing standard methodology, with both treated and untreated cotton fabric. The fabric was treated with tetrakis (hydroxymethyl) phosphonium hydroxide and subsequently cured with gaseous ammonia. The final treatment comprised adding on dicyandiamine phosphoric acid. None of the individuals experienced primary irritant or allergic reactions attributable to the fabric during induction or challenge patch testing. Likewise, there were no reactions to treated or untreated fabric patches placed on ten subjects of the usage panel at the conclusion of the study.

  18. Quantitative Evaluation of Peptide-Material Interactions by a Force Mapping Method: Guidelines for Surface Modification.

    PubMed

    Mochizuki, Masahito; Oguchi, Masahiro; Kim, Seong-Oh; Jackman, Joshua A; Ogawa, Tetsu; Lkhamsuren, Ganchimeg; Cho, Nam-Joon; Hayashi, Tomohiro

    2015-07-28

    Peptide coatings on material surfaces have demonstrated wide application across materials science and biotechnology, facilitating the development of nanobio interfaces through surface modification. A guiding motivation in the field is to engineer peptides with a high and selective binding affinity to target materials. Herein, we introduce a quantitative force mapping method in order to evaluate the binding affinity of peptides to various hydrophilic oxide materials by atomic force microscopy (AFM). Statistical analysis of adhesion forces and probabilities obtained on substrates with a materials contrast enabled us to simultaneously compare the peptide binding affinity to different materials. On the basis of the experimental results and corresponding theoretical analysis, we discuss the role of various interfacial forces in modulating the strength of peptide attachment to hydrophilic oxide solid supports as well as to gold. The results emphasize the precision and robustness of our approach to evaluating the adhesion strength of peptides to solid supports, thereby offering guidelines to improve the design and fabrication of peptide-coated materials.

  19. Network modeling and an evaluation of a CD proposed ISMS

    SciTech Connect

    Claassen, J.P.

    1996-03-01

    This report briefly describes the improvements and corrections made to a seismic network performance modeling code called NetSim. After expanding its supporting database, the modified code was used to predict the detection and location performances of an International Seismic Monitoring System (ISMS) proposed early in 1995 by the Group of Scientific Experts (GSE) supporting the Comprehensive Test Ban Treaty (CTBT) negotiators. The performance estimates indicated that the primary network achieves or exceeds the GSE goal of detecting a fully coupled 1kiloton nuclear shot contained in consolidated rock anywhere on the earth. It was also shown that without calibrated regional location models, the primary network alone cannot achieve the GSE location accuracy requirement of 1000 square kilometers at the detection threshold of the primary network, but with the help of 67 auxiliary stations that goal can be achieved in the northern hemisphere. Once the regional location models become better calibrated, the predictions based on these models indicated that the primary network should be able to realize the GSE requirement throughout much of the world. However, the location accuracy requirement is not realized in Central America, on the oceanic islands, on continental margins in the southern hemisphere, and in Antarctica. The introduction of the 67 auxiliary stations into the calibrated network primarily broadens the regions already having good location accuracies. The location performance estimates may be regarded as conservative since the S-wave arrivals were not included A comprehensive set of scenarios are illustrated in this effort to better understand various influences on network performance.

  20. 77 FR 12322 - Notice of Submission of Proposed Information Collection to OMB; Evaluation of the Veterans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... Veterans Homelessness Prevention Demonstration AGENCY: Office of the Chief Information Officer, HUD. ACTION... information required to evaluate the Veterans Homelessness Prevention Demonstration (VHPD). The Department... following information: Title of Proposal: Evaluation of the Veterans Homelessness Prevention...

  1. 75 FR 9279 - Proposed Information Collection (Survey of Satisfaction With the Disability Evaluation System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF VETERANS AFFAIRS Proposed Information Collection (Survey of Satisfaction With the Disability Evaluation System (DES... of Satisfaction with the Disability Evaluation System (DES). OMB Control Number: 2900-New (DES)....

  2. Evaluation of the test method activated sludge, respiration inhibition test proposed by the OECD

    SciTech Connect

    Yoshioka, Y.; Nagase, H.; Ose, Y.; Sato, T.

    1986-12-01

    The test method of activated sludge, respiration inhibition test proposed by the OECD was critically carried out and compared with other test methods. Investigation of test conditions showed that the moderate deviation from the test conditions defined by the OECD Test Guidelines did not have much effect on the result, and some modifications were proposed to improve the method. This method had a poor detection limit compared with the LC50 test with Oryzias latipes and EC50 of the growth inhibition test with Tetrahymena pyriformis. The susceptivity of the method was particularly poor for the chemicals which were highly toxic in the other two tests.

  3. 23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Guidance Criteria for Evaluating Requests for Modifications to the National Highway System D Appendix D to Subpart A of Part 470 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH HIGHWAY SYSTEMS Federal-aid Highway Systems...

  4. Evaluation of exercise-respiratory system modifications and preliminary respiratory-circulatory system integration scheme

    NASA Technical Reports Server (NTRS)

    Gallagher, R. R.

    1974-01-01

    The respiratory control system, functioning as an independent system, is presented with modifications of the exercise subroutine. These modifications illustrate an improved control of ventilation rates and arterial and compartmental gas tensions. A very elementary approach to describing the interactions of the respiratory and circulatory system is presented.

  5. Enzymatic modification of palmarosa essential oil: chemical analysis and olfactory evaluation of acylated products.

    PubMed

    Ramilijaona, Jade; Raynaud, Elsa; Bouhlel, Charfeddine; Sarrazin, Elise; Fernandez, Xavier; Antoniotti, Sylvain

    2013-12-01

    We have developed an enzymatic protocol to modify the composition of palmarosa essential oil by acylation of its alcohol components by three different acyl donors at various rates. The resulting modified products were characterized by qualitative and quantitative analyses by gas chromatography, and their olfactory properties were evaluated by professional perfumers. We showed that our protocol resulted in two types of modifications of the olfactory properties. The first and most obvious effect observed was the decrease of the alcohol content, with the concomitant increase of the corresponding esters, along with their fruity notes (pear, most notably). The second and less obvious effect was the expression of notes from minor components ((E)-β-ocimene, linalool, β-caryophyllene, and farnesene), originally masked by the sweet-floral-rose odor of geraniol, present in 70% in the palmarosa essential oil used, and emergence of citrus, green, spicy and clove characters in the modified products. This methodology might be considered in the future as a sustainable route to new natural ingredients for the perfumer. PMID:24327448

  6. Endothelial cells grown on thin polyelectrolyte mutlilayered films: an evaluation of a new versatile surface modification.

    PubMed

    Boura, C; Menu, P; Payan, E; Picart, C; Voegel, J C; Muller, S; Stoltz, J F

    2003-09-01

    Endothelial cell seeding constitutes an appreciated method to improve blood compatibility of small-diameter vascular grafts. In this study, we report the development of a simple innovative technique based on multilayered polyelectrolyte films as cell adhesive substrates. Polyelectrolyte multilayered films ending by poly(sodium-4-styrenesulfonate)/poly(allylamine hydrochloride) (PSS/PAH) or poly(L-glutamic acid)/poly(D-lysine) (PGA/PDL) could enhance cell adhesion by modification of the physico-chemical properties of the surface. The biological responses of human umbilical vein endothelial cells seeded on the polyelectrolyte multilayer films, on PDL or PAH monolayers, and on control surfaces, were evaluated in terms of initial attachment, growth, cellular metabolic activity, endothelial phenotype, and adhesion. The results showed that polyelectrolyte multilayers neither induce cytotoxic effects nor alter the phenotype of the endothelial cells. The polyelectrolyte multilayered films enhanced initial cell attachment as compared to the polyelectrolyte monolayer. Cell growth observed on the films was similar to that on TCPS. Among the different coating tested, the film ending by PSS/PAH exhibited an excellent cellular biocompatibility and appeared to be the most interesting surface in terms of cellular adhesion and growth. Such films could be used to cover hydrophobic (cell resistant) substrates in order to promote cell colonization, thereby constituting an excellent material for endothelial cell seeding.

  7. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  8. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Early termination of research support: Evaluation of applications and proposals. 219.123 Section 219.123 National Defense Department of Defense....123 Early termination of research support: Evaluation of applications and proposals. (a)...

  9. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Evaluating proposals of foreign iron, steel... Evaluating proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured...

  10. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Evaluating proposals of foreign iron, steel... American Recovery and Reinvestment Act of 2009 § 176.110 Evaluating proposals of foreign iron, steel, and... cost of certain domestic iron, steel, and/or manufactured goods being unreasonable, in accordance...

  11. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  12. 45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of research support: Evaluation of applications and proposals. (a) The department or agency head may... 45 Public Welfare 3 2010-10-01 2010-10-01 false Early termination of research support: Evaluation of applications and proposals. 690.123 Section 690.123 Public Welfare Regulations Relating to...

  13. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Research Subjects § 46.123 Early termination of research support: Evaluation of applications and proposals... 45 Public Welfare 1 2010-10-01 2010-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare DEPARTMENT OF HEALTH AND...

  14. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....123 Early termination of research support: Evaluation of applications and proposals. (a) The... 32 National Defense 2 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 219.123 Section 219.123 National Defense Department of...

  15. 38 CFR 16.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (whether or not the research was subject to federal regulation). ... research support: Evaluation of applications and proposals. 16.123 Section 16.123 Pensions, Bonuses, and... research support: Evaluation of applications and proposals. (a) The department or agency head may...

  16. 77 FR 18848 - Notice of Submission of Proposed Information Collection to OMB; Choice Neighborhoods Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB; Choice Neighborhoods... public comments on the subject proposal. ] HUD is conducting an evaluation of the Choice Neighborhoods... collection of information from households living in the Choice Neighborhoods sites. This proposed...

  17. Modification of integrated partial payload lifting assembly

    NASA Technical Reports Server (NTRS)

    Groah, Melodie; Haddock, Michael; Woodworth, Warren

    1986-01-01

    The Integrated Partial Payload Lifting Assembly (IPPLA) is currently used to transport and load experimental payloads into the cargo bay of the Space Shuttle. It is unable to carry the astronaut/passenger tunnel without a structural modification. The purpose of this design is to create a removalbe modification that will allow the IPPLA to lift and carry the passenger tunnel. Modifications evaluated were full-length insert beams which would extend through the existing strongback arms. These beam proposals were eliminated because of high cost and weight. Other proposals evaluated were attachments of cantilever beams to the existing strongback areas. The cantilever proposals reduced cost and weight compared to the full-length modifications. A third method evaluated was to simply make modifications to one side of the IPPLA therefore reducing the materials of the cantilever proposals by 40 percent. The design of the modification selected was completed with two channel beams jointly welded to a centered steel plate. The extension arm modification is inserted into the existing strongback channel beams and bolted into place. Two extension arms are added to one side of the IPPLA to provide the extra length needed to accommodate the passenger tunnel. The center counterbalance will then be offset about 20 inches to center gravity and therefore maintain horizontal status. The extension arm modification was selected because of minimum cost, low weight, and minimal installation time.

  18. Proposed modifications to the RCRA post-closure permit for the Upper East Fork Poplar Creek Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Upper East Fork Poplar Creek Hydrogeologic Regime (permit number TNHW-088, EPA ID No. TN3 89 009 0001). The modifications are proposed to: (1) revise the current text for two of the Permit Conditions included in Permit Section II - General Facility Conditions, and (2) update the PCP with revised versions of the Y-12 Plant Groundwater Protection Program (GWPP) technical field procedures included in several of the Permit Attachments. The updated field procedures and editorial revisions are Class 1 permit modifications, as specified in Title 40, Code of Federal Regulations (CFR) {section}270.42; Appendix I - Classification of Permit Modifications. These modifications are summarized below.

  19. 77 FR 75251 - 60-Day Notice of Proposed Information Collection: Gilman Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... Notice of Proposed Information Collection: Gilman Evaluation Survey ACTION: Notice of request for public...: Gilman Evaluation Survey. OMB Control Number: None. Type of Request: New Collection. Originating Office... the Office of Policy and Evaluation, Bureau of Educational and Cultural Affairs, Department of...

  20. 78 FR 56908 - 30-Day Notice of Proposed Information Collection: Training Evaluation Form

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ... URBAN DEVELOPMENT 30-Day Notice of Proposed Information Collection: Training Evaluation Form AGENCY... Information Collection Title of Information Collection: Training Evaluation Form. OMB Approval Number: 2577... Evaluation Form is currently being used and will be used are: On-site Core Curriculum training in...

  1. 78 FR 40760 - 60-Day Notice of Proposed Information Collection: Training Evaluation Form

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ... URBAN DEVELOPMENT 60-Day Notice of Proposed Information Collection: Training Evaluation Form AGENCY... Evaluation Form. OMB Approval Number: 2577-0271. Type of Request: Extension of currently approved collection.... Examples of how the Training Evaluation Form is currently being used and will be used are: On-site...

  2. 77 FR 31584 - Proposed Information Collection; Comment Request; Generic Clearance for Program Evaluation Data...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... Clearance for Program Evaluation Data Collection AGENCY: National Institute of Standards and Technology... and qualitative--designed to evaluate our current programs from a customer's perspective. NIST proposes to perform program evaluation data collections by means of, but not limited to, focus...

  3. 10 CFR 501.102 - OFE evaluation of the record, decision and order for modification or rescission of a rule or order.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false OFE evaluation of the record, decision and order for modification or rescission of a rule or order. 501.102 Section 501.102 Energy DEPARTMENT OF ENERGY (CONTINUED... Order § 501.102 OFE evaluation of the record, decision and order for modification or rescission of...

  4. 75 FR 54295 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of SNAP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ...; ] DEPARTMENT OF AGRICULTURE Food and Nutrition Service Agency Information Collection Activities: Proposed Collection; Comment Request--Evaluation of SNAP Nutrition Education Practices Study AGENCY: Food and Nutrition Service (FNS), USDA. ACTION: Notice. SUMMARY: In accordance with the Paperwork Reduction Act...

  5. 40 CFR 35.937-4 - Solicitation and evaluation of proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Water Act § 35.937-4 Solicitation and evaluation of proposals. (a) Requests for professional services... relative importance attached to each criterion (a numerical weighted formula need not be utilized). (c)...

  6. 77 FR 66951 - Proposed Information Collection; Comment Request; BIS Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Bureau of Industry and Security Proposed Information Collection; Comment Request; BIS Program Evaluation AGENCY: Bureau of Industry and Security, Commerce. ACTION: Notice. SUMMARY: The Department of...

  7. Proposed risk evaluation guidelines for use by the DOE-AL Nuclear Explosive Safety Division in evaluating proposed shipments of nuclear components

    SciTech Connect

    Just, R.A.; Love, A.F.

    1997-10-01

    The licensing requirements of 10 CFR 71 (US Code of Federal Regulations) are the primary criteria used to license proposed US Department of Energy (DOE) shipments of nuclear components. However, if a shipment cannot meet 10 CFR 71 requirements, a Transportation System Risk Assessment (TSRA) is prepared to document: (1) the degree of compliance of proposed DOE shipments of nuclear components with applicable federal regulations, and (2) the risk associated with the proposed shipments. The Nuclear Explosive Safety Division (NESD) of the Department of Energy, Albuquerque Area Office (DOE-AL) is responsible for evaluating TSRAs and for preparing Safety Evaluation Reports (SERs) to authorize the off-site transport. Hazards associated with the transport may include the presence of fissile material, chemically and radiologically toxic uranium, and ionizing radiation. The Nuclear Regulatory Commission (NRC) has historically considered only radiological hazards in licensing the transport of radiological material because the US Department of Transportation considers licensing requirements of nonradiological (i.e., chemically toxic) hazards. The requirements of 10 CFR 71 are based primarily on consideration of radiological hazards. For completeness, this report provides information for assessing the effects of chemical toxicity. Evaluating the degree of compliance with the requirements of 10 CFR 71 is relatively straightforward. However, there are few precedents associated with developing TSRA risk assessments for packages that do not comply with all of the requirements of 10 CFR 71. The objective of the task is to develop Risk Evaluation Guidelines for DOE-AL to use when evaluating a TSRA. If the TSRA shows that the Risk Evaluation Guidelines are not exceeded, then from a risk perspective the TSRA should be approved if there is evidence that the ALARA (as low as reasonably achievable) principle has been applied.

  8. A Proposal for a New Teacher Evaluation Process for the Delsea Regional School District

    ERIC Educational Resources Information Center

    Gravenor, Piera N.

    2011-01-01

    This executive position paper proposes recommendations for changes to the teacher evaluation policy and practice in the Delsea Regional School District. These recommendations are based upon best practices and evolving federal and state mandates in this area. A summarization of the current practice is provided along with proposed alternatives and…

  9. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Evaluating proposals of foreign iron, steel... proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods...

  10. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Evaluating proposals of foreign iron, steel... proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods...

  11. Improving Evaluation in Nonprofit Organizations: A Study of How Evaluation Requests for Proposals Are Developed, Responded to, and Fulfilled

    ERIC Educational Resources Information Center

    Matthews, Nakia S.

    2015-01-01

    It is often necessary for nonprofit organizations (NPOs) to formulate a Request for Proposal (RFP) to procure essential contracted services. This is most common when seeking the services of an external evaluator. Since most NPOs do not have internal evaluation staff, developing an appropriate RFP can be quite challenging. With limited literature…

  12. Evaluation of Heterogeneous Metal-Organic Framework Organocatalysts Prepared by Postsynthetic Modification

    PubMed Central

    Garibay, Sergio J.; Wang, Zhenqiang; Cohen, Seth M.

    2010-01-01

    A metal-organic framework (MOF) containing 2-amino-1,4-benzenedicarboxylate (NH2-BDC) as a building block is shown to undergo chemical modification with a set of cyclic anhydrides. The modification of the aluminum-based MOF known as MIL-53(Al)-NH2 (MIL = Matérial Institut Lavoisier) by these reagents is demonstrated by using a variety of methods, including NMR and ESI-MS, and the structural integrity of the modified MOFs has been confirmed by TGA, PXRD, and gas sorption analysis. Reaction with these cyclic anhydrides produces MOFs that display carboxylic acid functional groups within their pores. Furthermore, it is shown that maleic acid functionalized MIL-53(Al)-AMMal can act as a Brønsted acid catalyst and facilitate the methanolysis of several small epoxides. Experiments show that MIL-53(Al)-AMMal acts in a heterogeneous manner and is recyclable with consistent activity over at least three catalytic cycles. The findings presented here demonstrate several important features of covalent postsynthetic modification (PSM) on MOFs, including: 1) facile introduction of catalytic functionality using simple organic reagents (e.g. anhydrides); 2) the ability to utilize and recycle organocatalytic MOFs; 3) control of catalytic activity through choice of functional group. The findings clearly illustrate that covalent postsynthetic modification represents a powerful means to access new MOF compounds that serve as organocatalytic materials. PMID:20698561

  13. Evaluation of a Cooperative Extension Curriculum in Florida: Food Modification for Special Needs

    ERIC Educational Resources Information Center

    Dahl, Wendy J.; Ford, Amanda L.; Radford, Allyson; Gal, Nancy J.

    2016-01-01

    State and national surveys of adult family care homes identified a strong need for education on texture-modified food preparation and the nutritional needs of older adults. An Extension curriculum, Food Modification for Special Needs, was developed to provide an overview of chewing and swallowing problems, food texture, pureed food preparation,…

  14. Formative Evaluation of Project "TEAM" (Teens Making Environment and Activity Modifications)

    ERIC Educational Resources Information Center

    Kramer, Jessica M.; Roemer, Kristin; Liljenquist, Kendra; Shin, Julia; Hart, Stacy

    2014-01-01

    Research documents the negative impact of physical and social environmental barriers on engagement in school, work, and the community for youth with intellectual and /or developmental disabilities (IDD). Project "TEAM" (Teens making Environment and Activity Modifications) was designed to teach youth to systematically identify…

  15. 7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Early termination of research support: Evaluation of applications and proposals. 1c.123 Section 1c.123 Agriculture Office of the Secretary of Agriculture PROTECTION OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications...

  16. 22 CFR 225.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Early termination of research support: Evaluation of applications and proposals. 225.123 Section 225.123 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.123 Early termination of research support: Evaluation...

  17. 49 CFR 11.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Early termination of research support: Evaluation of applications and proposals. 11.123 Section 11.123 Transportation Office of the Secretary of Transportation PROTECTION OF HUMAN SUBJECTS § 11.123 Early termination of research support: Evaluation...

  18. 22 CFR 225.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Early termination of research support: Evaluation of applications and proposals. 225.123 Section 225.123 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.123 Early termination of research support: Evaluation...

  19. 45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Early termination of research support: Evaluation of applications and proposals. 690.123 Section 690.123 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.123 Early termination of research support: Evaluation...

  20. 45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Early termination of research support: Evaluation... Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.123 Early termination of research support: Evaluation of applications and proposals. (a) The department or agency head...

  1. 28 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROTECTION OF HUMAN SUBJECTS § 46.123 Early termination of research support: Evaluation...

  2. 7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1c.123 Section 1c.123 Agriculture Office of the Secretary of Agriculture PROTECTION OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications...

  3. 49 CFR 11.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Early termination of research support: Evaluation of applications and proposals. 11.123 Section 11.123 Transportation Office of the Secretary of Transportation PROTECTION OF HUMAN SUBJECTS § 11.123 Early termination of research support: Evaluation...

  4. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 97.123 Section 97.123 Education Office of the Secretary, Department of Education... Protection of Human Research Subjects) § 97.123 Early termination of research support: Evaluation...

  5. 22 CFR 225.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Early termination of research support: Evaluation of applications and proposals. 225.123 Section 225.123 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.123 Early termination of research support: Evaluation...

  6. 40 CFR 26.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 26.123 Section 26.123 Protection of Environment ENVIRONMENTAL... Research Conducted or Supported by EPA § 26.123 Early termination of research support: Evaluation...

  7. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... of human subjects (whether or not the research was subject to Federal regulation). ... 10 Energy 4 2012-01-01 2012-01-01 false Early termination of research support: Evaluation of... § 745.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  8. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of human subjects (whether or not the research was subject to Federal regulation). ... 10 Energy 4 2014-01-01 2014-01-01 false Early termination of research support: Evaluation of... § 745.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  9. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of human subjects (whether or not the research was subject to Federal regulation). ... 10 Energy 4 2011-01-01 2011-01-01 false Early termination of research support: Evaluation of... § 745.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  10. 62 FR 38568 - Submission for OMB Review; 30-Day Comment Period Proposed Information Collection: Evaluation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-07-18

    ... Information Collection: Evaluation of the IHS-Supported Alcohol and Substance Abuse Treatment Programs for... was previously published in the Federal Register (62 FR 15191) and allowed 60 days for public comment... to be submitted to OMB. Proposed Collection. Title: Evaluation of the IHS-Supported Alcohol...

  11. 78 FR 15801 - 30-Day Notice of Proposed Information Collection: Gilman Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... Notice of Proposed Information Collection: Gilman Evaluation Survey ACTION: Notice of request for public... halemj2@state.gov . SUPPLEMENTARY INFORMATION: Title of Information Collection: Gilman Evaluation Survey... SurveyGizmo. Dated: February 28, 2013. Matt Lussenhop, Director of the Office of Policy and...

  12. NASA RECON: Course development, administration, and evaluation. A research and development proposal

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Roquemore, Leroy

    1984-01-01

    This proposal addresses the development, administration, and evaluation of a set of transportable, college-level courses to educate science and engineering students in the effective use of automated scientific and technical information storage and retrieval systems, and, in particular, in the use of the NASA RECON system. Chapter 1 presents a brief introduction. Chapter 2 identifies general and specific objectives, i.e., needs analysis, course development, course administration, and course evaluation. Chapter 3 proposes the methodology to be used in successfully accomplishing these objectives. Chapter 4 highlights expected results and product deliverables, and Chapter 5 presents the project evaluation plan to be followed. Chapter 6 is a brief overview of the institutional resources available at the proposing institutions, i.e., at the University of Southwestern Louisiana and at Southern University to support the project. Chapter 7 proposes a budget, time schedule, and management plan. Chapter 8 is a summary of the foregoing.

  13. A Numerical model to evaluate proposed ground-water allocations in southwest Kansas

    USGS Publications Warehouse

    Jorgensen, D.G.; Grubb, H.F.; Baker, C.H.; Hilmes, G.E.; Jenkins, E.D.

    1982-01-01

    A computer model was developed to assist the Southwest Kansas Groundwater Management District No. 3 in the evaluation of applications to appropriate ground water. The model calculated the drawdown due from a proposed well at all existing wells in the section of the proposed well and at all wells in the adjacent eight sections. The depletion expected in the 9-square-mile area due to all existing wells and the proposed well is computed and compared with allowable limits defined by the management district. An optional program permits the evaluation of allowable depletion for one or more townships. All options are designed to run interactively, thus allowing for immediate evaluation of proposed ground-water withdrawals. (USGS)

  14. Evaluation of the Cask Transportation Facility Modifications (CTFM) compliance to DOE order 6430.1A Project A.5 and A.6

    SciTech Connect

    ARD, K.E.

    2000-04-24

    This report was prepared to evaluate the compliance of CTFM to DOE Order 6430.1A. This document presents the results of an evaluation that was performed to assess compliance of the K West (KW) Cask Transportation Facility Modifications (CTFM) designs against applicable requirements of Department of Energy (DOE) Order 6430.1 A, General Design Criteria. This evaluation was grouped under two categories described as Cask Loadout System (CLS) and Cranes/Other Modifications.

  15. Calendar year 1994 groundwater quality report for the Bear Creek hydrogeologic regime, Y-12 Plant, Oak Ridge, Tennessee. 1994 Groundwater quality data interpretations and proposed program modifications

    SciTech Connect

    1995-10-01

    This groundwater quality report (GWQR) contains an evaluation of the groundwater quality data obtained during the 1994 calendar year (CY) at several hazardous and non-hazardous waste management facilities at the US Department of Energy (DOE) Y-12 Plant. These sites lie in Bear Creek Valley (BCV) west of the Y-12 Plant within the boundaries of the Bear Creek Hydrogeologic Regime which is one of three hydrogeologic regimes defined for the purposes of groundwater quality monitoring. The Environmental Management Department manages the groundwater monitoring activities under the auspices of the Y-12 Plant Groundwater Protection Program (GWPP). The purpose of the GWPP is to characterize the hydrogeology and to monitor groundwater quality at the Y-12 Plant and surrounding area to protect local groundwater resources. The annual GWQR for the Bear Creek Regime is completed in two parts. Part 1 consists primarily of data appendices and serves as a reference for the groundwater quality data obtained each CY. Part 2 (this report) contains an evaluation of the data with respect to regime-wide groundwater quality, summarizes the status and findings of ongoing hydrogeologic studies, describes changes in monitoring priorities, and presents planned modifications to the groundwater sampling and analysis activities.

  16. Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity

    PubMed Central

    Subba Rao, G. S. R.; Kondaiah, Paturu; Singh, Sanjay K.; Ravanan, Palaniyandi; Sporn, Michael B.

    2008-01-01

    Synthetic analogues of naturally occurring triterpenoids; glycyrrhetinic acid, arjunolic acid and boswellic acids, by modification of A-ring with a cyano- and enone- functionalities, have been reported. A novel method of synthesis of α-cyanoenones from isoxazoles is reported. Bio-assays using primary mouse macrophages and tumor cell lines indicate potent anti-inflammatory and cytotoxic activities associated with cyanoenones of boswellic acid and glycyrrhetinic acid. PMID:20622928

  17. A prototype decision aid for evaluating and selecting R&D proposals

    SciTech Connect

    Al-Ayat, R.A.; Lamont, A.; Sicherman, A.

    1992-05-01

    This report describes a prototype decision aid which has been developed to assist the Institutional Research and Development (IR&D) Committee in selecting proposals for funding. This tool was requested to help address the following concerns about the IR&D proposal selection process: Some good proposals might be overlooked simply because no one on the Committee advocates them forcefully. The process takes a lot of time. The final portfolio of proposals selected may not maximize the long-run benefits to the Laboratory. These concerns stem from the observation that there is no formal framework for making distinctions between proposals, or weighing and comparing those distinctions. It was felt that the process could be improved by a framework that: Provides explicit descriptors that Committee members can use to evaluate and compare different features of proposals. Encourages the Committee to use a uniform, systematic scheme for evaluating the proposals. Helps the Committee focus more quickly on the issues that are truly relevant for distinguishing between proposals.

  18. Calendar year 1993 groundwater quality report for the Chestnut Ridge Hydrogeologic Regime Y-12 Plant, Oak Ridge, Tennessee. 1993 Groundwater quality data interpretations and proposed program modifications

    SciTech Connect

    1994-09-01

    This groundwater quality report (GWQR) contains an evaluation of the groundwater quality data obtained during the 1993 calendar year (CY) at several hazardous and non-hazardous waste management facilities associated with the US DOE Y-12 Plant located on the DOE Oak Ridge Reservation (ORR) southeast of Oak Ridge, Tennessee. The groundwater quality data are presented in Part 1 of the GWQR submitted by Martin Marietta Energy Systems, Inc. to the Tennessee Department of Environment and Conservation (TDEC) in February 1994. Groundwater quality data evaluated in this report were obtained at several hazardous and non-hazardous waste management sites located within the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime). The Chestnut Ridge Regime encompasses a section of Chestnut Ridge south of the Y-12 Plant and is one of three hydrogeologic regimes defined for the purposes of groundwater quality monitoring at the plant. The Environmental Management Department of the Y-12 Plant Health, Safety, Environment, and Accountability Organization manages the groundwater monitoring activities in each regime as part of the Y-12 Plant Groundwater Protection Program (GWPP). The annual GWQR for the Chestnut Ridge Regime is completed in two parts. Part 1 consists primarily of data appendices and serves as a reference for the groundwater quality data obtained each CY under the lead of the Y-12 Plant GWPP. Because it contains information needed to comply with Resource Conservation and Recovery Act (RCRA) interim status assessment monitoring and reporting requirements, the Part 1 GWQR is submitted to the TDEC by the RCRA reporting deadline (March 1 of the following CY). Part 2 (this report) contains an evaluation of the data with respect to regime-wide groundwater quality, presents the findings and status of ongoing hydrogeologic studies, describes changes in monitoring priorities, and presents planned modifications to the groundwater sampling and analysis activities.

  19. Modification and Adaptation of the Program Evaluation Standards in Saudi Arabia

    ERIC Educational Resources Information Center

    Alyami, Mohammed

    2013-01-01

    The Joint Committee on Standards for Educational Evaluation's Program Evaluation Standards is probably the most recognized and applied set of evaluation standards globally. The most recent edition of The Program Evaluation Standards includes five categories and 30 standards. The five categories are Utility, Feasibility, Propriety, Accuracy,…

  20. Plasma surface modification of fibroporous polycarbonate urethane membrane by polydimethyl siloxane: structural characterization, mechanical properties, and in vitro cytocompatibility evaluation.

    PubMed

    Arjun, G N; Menon, Girish; Ramesh, P

    2014-04-01

    This article reports the surface modification of electrospun polycarbonate urethane membrane with polydimethyl siloxane (PDMS) using plasma-induced grafting technique for biomedical applications. The nonwoven membranes were characterized for their structure, performance, and compatibility with cells. The surface modification was confirmed by means of attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and energy dispersive X-ray analysis (EDXA). ATR-FTIR and EDXA analyses displayed characteristic absorption peaks of PDMS for the membrane. The structure and morphology of the developed membranes were studied using scanning electron microscope and microcomputed tomography (µCT). Scanning electron microscopy and µCT revealed the fibrous morphology and percentage porosity of the membranes before and after plasma modification. Static mechanical tests showed that the tensile strength was greater than 8 MPa. Physical characterization of the membranes after immersion in hydrolytic and oxidative media supports their biostability. Cytotoxicity of the membrane was evaluated using L929 fibroblast cells, and the results indicated that the membrane is cytocompatible. Accordingly, these results highlight the potential of this fibrous membrane for biomedical applications. PMID:23650270

  1. Plasma surface modification of fibroporous polycarbonate urethane membrane by polydimethyl siloxane: structural characterization, mechanical properties, and in vitro cytocompatibility evaluation.

    PubMed

    Arjun, G N; Menon, Girish; Ramesh, P

    2014-04-01

    This article reports the surface modification of electrospun polycarbonate urethane membrane with polydimethyl siloxane (PDMS) using plasma-induced grafting technique for biomedical applications. The nonwoven membranes were characterized for their structure, performance, and compatibility with cells. The surface modification was confirmed by means of attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and energy dispersive X-ray analysis (EDXA). ATR-FTIR and EDXA analyses displayed characteristic absorption peaks of PDMS for the membrane. The structure and morphology of the developed membranes were studied using scanning electron microscope and microcomputed tomography (µCT). Scanning electron microscopy and µCT revealed the fibrous morphology and percentage porosity of the membranes before and after plasma modification. Static mechanical tests showed that the tensile strength was greater than 8 MPa. Physical characterization of the membranes after immersion in hydrolytic and oxidative media supports their biostability. Cytotoxicity of the membrane was evaluated using L929 fibroblast cells, and the results indicated that the membrane is cytocompatible. Accordingly, these results highlight the potential of this fibrous membrane for biomedical applications.

  2. Numerical performance evaluation of design modifications on a centrifugal pump impeller running in reverse mode

    NASA Astrophysics Data System (ADS)

    Kassanos, Ioannis; Chrysovergis, Marios; Anagnostopoulos, John; Papantonis, Dimitris; Charalampopoulos, George

    2016-06-01

    In this paper the effect of impeller design variations on the performance of a centrifugal pump running as turbine is presented. Numerical simulations were performed after introducing various modifications in the design for various operating conditions. Specifically, the effects of the inlet edge shape, the meridional channel width, the number of blades and the addition of splitter blades on impeller performance was investigated. The results showed that, an increase in efficiency can be achieved by increasing the number of blades and by introducing splitter blades.

  3. Evaluation of dredged material proposed for ocean disposal from Buttermilk Channel, New York

    SciTech Connect

    Gardiner, W.W.; Barrows, E.S.; Antrim, L.D; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-08-01

    Buttermilk Channel was one of seven waterways that was sampled and evaluated for dredging and sediment disposal. Sediment samples were collected and analyses were conducted on sediment core samples. The evaluation of proposed dredged material from the channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples were analyzed for grain size, moisture content, and total organic carbon. A composite sediment samples, representing the entire area proposed for dredging, was analyzed for bulk density, polynuclear aromatic hydrocarbons, and 1,4-dichlorobenzene. Site water and elutriate were analyzed for metals, pesticides, and PCBs.

  4. Evaluation of organosolv processes for the fractionation and modification of corn stover for bioconversion

    SciTech Connect

    Lee, Y.H.; Robinson, C.W.; Moo-Young, M.

    1987-04-01

    Corn stover was pretreated for compositional fractionation and structural modification for maximum conversion of carbohydrate to soluble sugars. The process scheme consisted of three steps: (1) mild prehydrolysis if dilute sulfuric acid, (2) delignification with various organosolv solvents, and (3) enzymatic hydrolysis in an agitated bead reactor. Prehydrolysis of corn stover can be achieved at temperature ranging from 95 to 120/sup 0/C, which is a much milder condition than must be applied to wood. Various organosolv solvents, including several alcohols with acid as catalyst, ethylene glycol, and its derivatives, and amines were used for delignification of the prehydrolyzed corn stover. The low enzymic conversion (20-37%) of prehydrolzyed and solvent-extracted corn stover that was achieved implies that lignin is not the only major barrier for enzymatic hydrolysis. Modification of cellulose structure also should be accomplished to achieve a high degree of conversion. Enzymatic hydrolysis in the agitated bead system increased the rate and extent of conversion of corn stover substantially compared to systems without beads.

  5. Proposal and Evaluation of Management Method for College Mechatronics Education Applying the Project Management

    NASA Astrophysics Data System (ADS)

    Ando, Yoshinobu; Eguchi, Yuya; Mizukawa, Makoto

    In this research, we proposed and evaluated a management method of college mechatronics education. We applied the project management to college mechatronics education. We practiced our management method to the seminar “Microcomputer Seminar” for 3rd grade students who belong to Department of Electrical Engineering, Shibaura Institute of Technology. We succeeded in management of Microcomputer Seminar in 2006. We obtained the good evaluation for our management method by means of questionnaire.

  6. Design requirements for SRB production control system. Volume 3: Package evaluation, modification and hardware

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The software package evaluation was designed to analyze commercially available, field-proven, production control or manufacturing resource planning management technology and software package. The analysis was conducted by comparing SRB production control software requirements and conceptual system design to software package capabilities. The methodology of evaluation and the findings at each stage of evaluation are described. Topics covered include: vendor listing; request for information (RFI) document; RFI response rate and quality; RFI evaluation process; and capabilities versus requirements.

  7. 38 CFR 16.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Early termination of research support: Evaluation of applications and proposals. 16.123 Section 16.123 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.123 Early termination...

  8. 38 CFR 16.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Early termination of research support: Evaluation of applications and proposals. 16.123 Section 16.123 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.123 Early termination...

  9. 77 FR 30512 - Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ... Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy Development; Strategies for Preparing At-Risk Youth for Postsecondary Success SUMMARY: Strategies for Preparing At-Risk Youth for Postsecondary Success focuses on preventing students from dropping out and preparing them...

  10. 43 CFR 404.22 - How will Reclamation evaluate my full proposal?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false How will Reclamation evaluate my full proposal? 404.22 Section 404.22 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Overview § 404.22 How...

  11. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  12. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  13. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  14. 78 FR 26396 - Proposed Collection; Comments Requested: FBI National Academy Level 1 Evaluation: Student Course...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Proposed Collection; Comments Requested: FBI National Academy Level 1 Evaluation: Student Course Questionnaire and FBI National Academy: General Remarks Questionnaire ACTION: 30-Day Notice. The Department of Justice (DOJ), Federal Bureau of Investigation...

  15. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  16. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Proposal evaluation criteria and scoring applications. 4284.942 Section 4284.942 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS...

  17. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Proposal evaluation criteria and scoring applications. 4284.942 Section 4284.942 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS...

  18. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Proposal evaluation criteria and scoring applications. 4284.942 Section 4284.942 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS...

  19. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  20. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  1. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  2. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  3. Evaluating a Proposed Learning Experience in Terms of Eight Learning Theories.

    ERIC Educational Resources Information Center

    Abram, Marie J.

    The work of eight learning theorists was used to evaluate a proposed adult education/learning experience in an effort to operationalize a system for locating strengths and weaknesses in an instructional system prior to its implementation. Thirty-five implications for adult education were extrapolated from work representing the Behaviorist (B.F.…

  4. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  5. 16 CFR 1028.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1028.123 Section 1028.123 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL PROTECTION OF HUMAN SUBJECTS § 1028.123 Early termination of research...

  6. 15 CFR 27.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 27.123 Section 27.123 Commerce and Foreign Trade Office of the Secretary of Commerce PROTECTION OF HUMAN SUBJECTS § 27.123 Early termination of research...

  7. 14 CFR § 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (whether or not the research was subject to federal regulation). ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Early termination of research support... termination of research support: Evaluation of applications and proposals. (a) The department or agency...

  8. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Evaluating proposals of foreign iron, steel... iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods being unreasonable,...

  9. 62 FR 15191 - Proposed Collection; Comment Request; Evaluation of the IHS- Supported Alcohol and Substance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-03-31

    ...- Supported Alcohol and Substance Abuse Treatment Programs for American Indian/Alaska Native Women SUMMARY: In.... Proposed Collection Title: Evaluation of the IHS-Supported Alcohol and Substance Abuse Treatment Program... Use of the Information Collection: Section 703, ``Indian Women Treatment Programs'' of Public Law...

  10. 76 FR 57767 - Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... appearing in the Federal Register on September 1, 2011 (76 FR 54507), that requested public comment on Draft... Register document 2011-22422, published September 1, 2011 (76 FR 54507), in the second column, under the... COMMISSION Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations...

  11. 77 FR 56634 - Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ..., management, and budget decision-making processes for all K-12 educational programs, has transformed the way... SEAs to enable better analysis and use in policy development, planning, and management. DATES... Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

  12. Modifications to CTVS TV cameras for space shuttle compatibility and evaluation

    NASA Astrophysics Data System (ADS)

    Hoagland, K.

    1981-08-01

    Five all solid state cockpit television system (CTVS) cameras, built to USAF requirements for high performance type F-16 aircraft, were modified and tested for possible use in the closed circuit television system on the space shuttle orbiter. The 400 HZ power supply in the electronics unit assembly was replaced with two DC/DC converters to enable operation from 28VDC spacecraft-type power sources. Nonessential circuit functions were deleted to minimize input power requirements. The normal 31 mm focal length lense assemblies were replaced with wider field-of-view 19 mm focal length lenses. Base plates for and housings were redesigned to facilitate mounting and heat-sinking of the camera in the space environment and short length (14") adapter cables were designed, fabricated, and tested to meet requirements for cameras configured to mount on the astronauts helmet/visor assembly. Technical requirements, design implementation, environmental tests, Modifications prodedures, and reliability/quality efforts are discussed. Schematics are included.

  13. Comparative temporal analysis of multiwalled carbon nanotube oxidation reactions: Evaluating chemical modifications on true nanotube surface

    NASA Astrophysics Data System (ADS)

    Pacheco, Flávia G.; Cotta, Alexandre A. C.; Gorgulho, Honória F.; Santos, Adelina P.; Macedo, Waldemar A. A.; Furtado, Clascídia A.

    2015-12-01

    The influence of extensive purification on oxidized multiwalled carbon nanotube surface composition was studied through the characterization and differentiation of the actual surface submitted to three oxidation methods: microwave-assisted acid oxidation, hydrogen peroxide reflux, and Fenton reaction. The oxidized samples were purified by a multi-step procedure including the sequential use of basic reflux and dispersion in dimethylformamide (DMF). The results showed a significant increase in the amount of oxidation debris with hydrogen peroxide and Fenton reaction times longer than 8 h and strong surface characteristic modification. With regard to sample purification, basic reflux led to a reduction in oxygenated group concentration of only 10% in the samples treated by acid oxidation. On the other hand, the subsequent use of DMF led to a further decrease in concentration of 39%, proving to be a more efficient method for the removal of oxidation debris.

  14. Modifications to CTVS TV cameras for space shuttle compatibility and evaluation

    NASA Technical Reports Server (NTRS)

    Hoagland, K.

    1981-01-01

    Five all solid state cockpit television system (CTVS) cameras, built to USAF requirements for high performance type F-16 aircraft, were modified and tested for possible use in the closed circuit television system on the space shuttle orbiter. The 400 HZ power supply in the electronics unit assembly was replaced with two DC/DC converters to enable operation from 28VDC spacecraft-type power sources. Nonessential circuit functions were deleted to minimize input power requirements. The normal 31 mm focal length lense assemblies were replaced with wider field-of-view 19 mm focal length lenses. Base plates for and housings were redesigned to facilitate mounting and heat-sinking of the camera in the space environment and short length (14") adapter cables were designed, fabricated, and tested to meet requirements for cameras configured to mount on the astronauts helmet/visor assembly. Technical requirements, design implementation, environmental tests, Modifications prodedures, and reliability/quality efforts are discussed. Schematics are included.

  15. Proposed Amendment to Presidential Permit PP-63 and Associated Modifications to 500-kV International Transmission Line: Forbes, Minnesota to Manitoba, Canada, Northern States Power Company. Addendum to the final Environmental Assessment

    SciTech Connect

    Not Available

    1992-10-01

    This Addendum to the Final Environmental Assessment for the Proposed Amendment to Presidential Permit PP-63 and Associated Modifications to 500 kV International Transmission Line: Forbes, Minnesota to Manitoba, Canada (DOE/EA-587) addresses Northern States Power Company`s (NSP) proposed expansion of the Forbes Substation. The applicant has requested that the expansion take place on the west side of the substation, within the existing property line, instead of on the north side as originally proposed. All of the proposed construction would take place on property already owned by NSP. DOE has reviewed the environmental impacts associated with this minor modification and has determined that the conclusions reached in the environmental assessment and Finding of No Significant Impact prepared in connection with NSP`s original amendment request remain valid.

  16. Evaluation of two cell surface modification methods for proteomic analysis of plasma membrane from isolated mouse hepatocytes.

    PubMed

    Li, Xuanwen; Jin, Qihui; Cao, Jia; Xie, Chunliang; Cao, Rui; Liu, Zhen; Xiong, Jixian; Li, Jianglin; Yang, Xiaoxu; Chen, Ping; Liang, Songping

    2009-01-01

    The hepatocyte is a highly polarized cell with a heterogeneous distribution of plasma-membrane (PM) proteins. To reduce the complexity of the proteome of liver tissue and give a comprehensive profile of hepatocyte PM, two PM purification methods based on cell surface modification, named the biotin-avidin (BA) and cationic silica-polyanion (CSP) strategies were evaluated and compared with the traditional cell fractionation method to prepare highly enriched PM from freshly isolated C57 mouse hepatocytes. Employing different principles for PM modification, both methods were effective in the isolation of general and purified PM fraction. The CSP strategy showed better yield for the PM purification from freshly isolated hepatocytes. 189 non-redundant proteins were identified, including 49 from the BA method and 185 from CSP strategy. Many known and novel PM-associated proteins were also found. Our evaluation here should give implications for PM preparation from other freshly isolated tissue-derived cells. The hepatocyte PM proteins identified here should be taken as a references for the PM-related functional and diseases research.

  17. Proposed Framework for the Evaluation of Standalone Corpora Processing Systems: An Application to Arabic Corpora

    PubMed Central

    Al-Thubaity, Abdulmohsen; Alqifari, Reem

    2014-01-01

    Despite the accessibility of numerous online corpora, students and researchers engaged in the fields of Natural Language Processing (NLP), corpus linguistics, and language learning and teaching may encounter situations in which they need to develop their own corpora. Several commercial and free standalone corpora processing systems are available to process such corpora. In this study, we first propose a framework for the evaluation of standalone corpora processing systems and then use it to evaluate seven freely available systems. The proposed framework considers the usability, functionality, and performance of the evaluated systems while taking into consideration their suitability for Arabic corpora. While the results show that most of the evaluated systems exhibited comparable usability scores, the scores for functionality and performance were substantially different with respect to support for the Arabic language and N-grams profile generation. The results of our evaluation will help potential users of the evaluated systems to choose the system that best meets their needs. More importantly, the results will help the developers of the evaluated systems to enhance their systems and developers of new corpora processing systems by providing them with a reference framework. PMID:25610910

  18. Evaluation of a proposed expert system development methodology: Two case studies

    NASA Technical Reports Server (NTRS)

    Gilstrap, Lewey

    1990-01-01

    Two expert system development projects were studied to evaluate a proposed Expert Systems Development Methodology (ESDM). The ESDM was developed to provide guidance to managers and technical personnel and serve as a standard in the development of expert systems. It was agreed that the proposed ESDM must be evaluated before it could be adopted; therefore a study was planned for its evaluation. This detailed study is now underway. Before the study began, however, two ongoing projects were selected for a retrospective evaluation. They were the Ranging Equipment Diagnostic Expert System (REDEX) and the Backup Control Mode Analysis and Utility System (BCAUS). Both projects were approximately 1 year into development. Interviews of project personnel were conducted, and the resulting data was used to prepare the retrospective evaluation. Decision models of the two projects were constructed and used to evaluate the completeness and accuracy of key provisions of ESDM. A major conclusion reached from these case studies is that suitability and risk analysis should be required for all AI projects, large and small. Further, the objectives of each stage of development during a project should be selected to reduce the next largest area of risk or uncertainty on the project.

  19. In vivo evaluation of plasma-sprayed titanium coating after alkali modification.

    PubMed

    Xue, Weichang; Liu, Xuanyong; Zheng, XueBin; Ding, Chuanxian

    2005-06-01

    In this paper, plasma-sprayed titanium coatings were modified by alkali treatment. The changes in chemical composition and structure of coatings were examined by SEM and AES. The results obtained indicated that a net-like microscopic texture feature, which was full of the interconnected fine porosity, appeared on the surface of alkali-modified titanium coatings. The surface chemical composition was also altered by alkali modification. A sodium titanate compound was formed on the surface of the titanium coating and replaced the native passivating oxide layer. Its thickness was measured as about 150 nm which was about 10 times of that of the as-sprayed coating. The bone bonding ability of titanium coatings were investigated using a canine model. The histological examination and SEM observation demonstrated that more new bone was formed on the surface of alkali-modified implants and grew more rapidly into the porosity. The alkali-modified implants were found to appose directly to the surrounding bone. In contrast, a gap was observed at the interface between the as-sprayed implants and bone. The push-out test showed that alkali-modified implants had a higher shear strength than as-sprayed implants after 1 month of implantation. An interfacial layer, containing Ti, Ca and P, was found to form at the interface between bone and the alkali-modified implant by EDS analysis.

  20. Evaluation of AUSDRISK as a screening tool for lifestyle modification programs: international implications for policy and cost-effectiveness

    PubMed Central

    Malo, Jonathan A; Versace, Vincent L; Janus, Edward D; Laatikainen, Tiina; Peltonen, Markku; Vartiainen, Erkki; Coates, Michael J; Dunbar, James A

    2015-01-01

    Objective To evaluate the current use of Australian Type 2 Diabetes Risk Assessment Tool (AUSDRISK) as a screening tool to identify individuals at high risk of developing type 2 diabetes for entry into lifestyle modification programs. Research Design and Methods AUSDRISK scores were calculated from participants aged 40–74 years in the Greater Green Triangle Risk Factor Study, a cross-sectional population survey in 3 regions of Southwest Victoria, Australia, 2004–2006. Biomedical profiles of AUSDRISK risk categories were determined along with estimates of the Victorian population included at various cut-off scores. Sensitivity, specificity, positive predictive value (PPV), negative predictive value, and receiver operating characteristics were calculated for AUSDRISK in determining fasting plasma glucose (FPG) ≥6.1 mmol/L. Results Increasing AUSDRISK scores were associated with an increase in weight, body mass index, FPG, and metabolic syndrome. Increasing the minimum cut-off score also increased the proportion of individuals who were obese and centrally obese, had impaired fasting glucose (IFG) and metabolic syndrome. An AUSDRISK score of ≥12 was estimated to include 39.5% of the Victorian population aged 40–74 (916 000), while a score of ≥20 would include only 5.2% of the same population (120 000). At AUSDRISK≥20, the PPV for detecting FPG≥6.1 mmol/L was 28.4%. Conclusions AUSDRISK is powered to predict those with IFG and undiagnosed type 2 diabetes, but its effectiveness as the sole determinant for entry into a lifestyle modification program is questionable given the large proportion of the population screened-in using the current minimum cut-off of ≥12. AUSDRISK should be used in conjunction with oral glucose tolerance testing, fasting glucose, or glycated hemoglobin to identify those individuals at highest risk of progression to type 2 diabetes, who should be the primary targets for lifestyle modification. PMID:26468399

  1. A pilot study evaluating a one-session attention modification training to decrease overeating in obese children

    PubMed Central

    Boutelle, Kerri N.; Kuckertz, Jennie M.; Carlson, Jordan; Amir, Nader

    2014-01-01

    There are a number of neurocognitive and behavioral mechanisms that contribute to overeating and obesity, including an attentional bias to food cues. Attention modification programs, which implicitly train attention away from specific cues, have been used in anxiety and substance abuse, and could logically be applied to food cues. The purpose of this study was to evaluate the initial efficacy of a single session attention modification training for food cues (AMP) on overeating in overweight and obese children. Twenty–four obese children who eat in the absence of hunger participated in two visits and were assigned to an attention modification program (AMP) or attentional control program (ACC). The AMP program trained attention away 100% of the time from food words to neutral words. The ACC program trained attention 50% of the time to neutral and 50% of the time to food. Outcome measures included the eating in the absence of hunger free access session, and measures of craving, liking and salivation. Results revealed significant treatment effects for EAH percent and EAH kcal (group by time interactions p < .05). Children in the ACC condition showed a significant increase over time in the number of calories consumed in the free access session (within group t=3.09, p=.009) as well as the percent of daily caloric needs consumed in free access (within group t=3.37, p=.006), whereas children in the AMP group demonstrated slight decreases in these variables (within group t=−0.75 and −0.63). There was a trend suggesting a beneficial effect of AMP as compared to ACC for attentional bias (group by time interaction p=.073). Changes in craving, liking and saliva were not significantly different between groups (ps=.178 to .527). This is the first study to demonstrate that an AMP program can influence eating in obese children. Larger studies are needed to replicate and extend these results. PMID:24512975

  2. A pilot study evaluating a one-session attention modification training to decrease overeating in obese children.

    PubMed

    Boutelle, Kerri N; Kuckertz, Jennie M; Carlson, Jordan; Amir, Nader

    2014-05-01

    There are a number of neurocognitive and behavioral mechanisms that contribute to overeating and obesity, including an attentional bias to food cues. Attention modification programs, which implicitly train attention away from specific cues, have been used in anxiety and substance abuse, and could logically be applied to food cues. The purpose of this study was to evaluate the initial efficacy of a single session attention modification training for food cues (AMP) on overeating in overweight and obese children. Twenty-four obese children who eat in the absence of hunger participated in two visits and were assigned to an attention modification program (AMP) or attentional control program (ACC). The AMP program trained attention away 100% of the time from food words to neutral words. The ACC program trained attention 50% of the time to neutral and 50% of the time to food. Outcome measures included the eating in the absence of hunger free access session, and measures of craving, liking and salivation. Results revealed significant treatment effects for EAH percent and EAH kcal (group by time interactions p<.05). Children in the ACC condition showed a significant increase over time in the number of calories consumed in the free access session (within group t=3.09, p=.009) as well as the percent of daily caloric needs consumed in free access (within group t=3.37, p=.006), whereas children in the AMP group demonstrated slight decreases in these variables (within group t=-0.75 and -0.63, respectively). There was a trend suggesting a beneficial effect of AMP as compared to ACC for attentional bias (group by time interaction p=.073). Changes in craving, liking and saliva were not significantly different between groups (ps=.178-.527). This is the first study to demonstrate that an AMP program can influence eating in obese children. Larger studies are needed to replicate and extend these results.

  3. 38 CFR 16.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... disposition of applications and proposals for research to be conducted or supported by a Federal Department or... PROTECTION OF HUMAN SUBJECTS § 16.120 Evaluation and disposition of applications and proposals for research... will evaluate all applications and proposals involving human subjects submitted to the department...

  4. 45 CFR 690.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposals for research to be conducted or supported by a Federal department or agency. 690.120 Section 690... PROTECTION OF HUMAN SUBJECTS § 690.120 Evaluation and disposition of applications and proposals for research... evaluate all applications and proposals involving human subjects submitted to the department or...

  5. Evaluation of enamel surface modification using PS-OCT after laser treatment to increase resistance to demineralization

    PubMed Central

    Kim, Jin Wan; Chan, Kenneth H.; Fried, Daniel

    2016-01-01

    At laser intensities below ablation, carbonated hydroxyapatite in enamel is converted into a purer phase hydroxyapatite with increased acid resistance. Previous studies suggested the possibility of achieving the conversion without surface modification. This study attempts to evaluate the thresholds for the modification without additional changes in physical and optical properties of the enamel. Bovine specimens were irradiated using an RF-excited CO2 laser operating at 9.4-µm with a pulse duration of 26-µs, pulse repetition rates of 100–1000 Hz, with a Gaussian spatial beam profile - 1.4 mm in diameter. After laser treatment, the samples were subjected to acid demineralization for 48 hours to simulate acidic intraoral conditions of a caries attack. The resulting demineralization and erosion were assessed using polarization sensitive OCT (PS-OCT) and 3D digital microscopy. The images from digital microscopy demonstrated a clear delineation between laser protected zones without visual changes and zones with higher levels of demineralization and erosion. Distinct changes in the surface morphology were found within the laser treated area in accordance with the Gaussian spatial beam profile. There was significant protection from the laser in areas that were not visually altered. PMID:27006523

  6. Evaluation of enamel surface modification using PS-OCT after laser treatment to increase resistance to demineralization

    NASA Astrophysics Data System (ADS)

    Kim, Jin Wan; Chan, Kenneth H.; Fried, Daniel

    2016-02-01

    At laser intensities below ablation, carbonated hydroxyapatite in enamel is converted into a purer phase hydroxyapatite with increased acid resistance. Previous studies suggested the possibility of achieving the conversion without surface modification. This study attempts to evaluate the thresholds for the modification without additional changes in physical and optical properties of the enamel. Bovine specimens were irradiated using an RF-excited CO2 laser operating at 9.4-μm with a pulse duration of 26- μs, pulse repetition rates of 100-1000 Hz, with a Gaussian spatial beam profile - 1.4 mm in diameter. After laser treatment, the samples were subjected to acid demineralization for 48 hours to simulate acidic intraoral conditions of a caries attack. The resulting demineralization and erosion were assessed using polarization sensitive OCT (PS-OCT) and 3D digital microscopy. The images from digital microscopy demonstrated a clear delineation between laser protected zones without visual changes and zones with higher levels of demineralization and erosion. Distinct changes in the surface morphology were found within the laser treated area in accordance with the Gaussian spatial beam profile. There was significant protection from the laser in areas that were not visually altered.

  7. SDS-PAGE and IR spectroscopy to evaluate modifications in the viral protein profile induced by a cationic porphyrinic photosensitizer.

    PubMed

    Costa, Liliana; Esteves, Ana Cristina; Correia, António; Moreirinha, Catarina; Delgadillo, Ivonne; Cunha, Ângela; Neves, Maria G P S; Faustino, Maria A F; Almeida, Adelaide

    2014-12-01

    Reactive oxygen species can be responsible for microbial photodynamic inactivation due to its toxic effects, which include severe damage to proteins, lipids and nucleic acids. In this study, the photo-oxidative modifications of the proteins of a non-enveloped T4-like bacteriophage, induced by the cationic porphyrin 5,10,15-tris(1-methylpyridinium-4-yl)-20-(pentafluorophenyl)porphyrin tri-iodide were evaluated. Two methods were used: sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and infrared spectroscopy. SDS-PAGE analysis showed that the phage protein profile was considerably altered after photodynamic treatment. Seven protein bands putatively corresponding to capsid and tail tube proteins were attenuated and two other were enhanced. Infrared spectroscopy confirmed the time-dependent alteration on the phage protein profile detected by SDS-PAGE, indicative of a response to oxidative damage. Infrared analysis showed to be a promising and rapid screening approach for the analysis of the modifications induced on viral proteins by photosensitization. In fact, one single infrared spectrum can highlight the changes induced to all viral molecular structures, overcoming the delays and complex protocols of the conventional methods, in a much simple and cost effective way. PMID:25241141

  8. CCRS proposal for evaluating LANDSAT-D MSS and TM data

    NASA Technical Reports Server (NTRS)

    Strome, W. M.; Cihlar, J.; Goodenough, D. G.; Guertin, F. E. (Principal Investigator); Collins, A. B.

    1983-01-01

    Accomplishments in the evaluation of LANDSAT 4 data are reported. The objectives of the Canadian proposal are: (1) to quantify the LANDSAT-4 sensors and system performance for the purpose of updating the radiometric and geometric correction algorithms for MSS and for developing and evaluating new correction algorithms to be used for TM data processing; (2) to compare and access the degree to which LANDSAT-4 MSS data can be integrated with MSS imagery acquired from earlier LANDSAT missions; and (3) to apply image analysis and information extraction techniques for specific user applications such as forestry or agriculture.

  9. Evaluation of dredged material proposed for ocean disposal from Shark River Project area

    SciTech Connect

    Antrim, L.D.; Gardiner, W.W.; Barrows, E.S.; Borde, A.B.

    1996-09-01

    The objective of the Shark River Project was to evaluate proposed dredged material to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Tests and analyses were conducted on the Shark River sediments. The evaluation of proposed dredged material consisted of bulk sediment chemical and physical analysis, chemical analyses of dredging site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation tests. Individual sediment core samples collected from the Shark River were analyzed for grain size, moisture content, and total organic carbon (TOC). One sediment composite was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4- dichlorobenzene. Dredging site water and elutriate, prepared from suspended-particulate phase (SPP) of the Shark River sediment composite, were analyzed for metals, pesticides, and PCBs. Benthic acute toxicity tests and bioaccumulation tests were performed.

  10. Proposed modifications to the RCRA post-closure permit for the Chestnut Ridge Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to several conditions of the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Chestnut Ridge Hydrogeologic Regime (CRHR) (permit number TNHW-088, EPA ID No. TN3 89 009 0001). These permit conditions define the requirements for RCRA post-closure detection groundwater monitoring at the Chestnut Ridge Sediment Disposal Basin (CRSDB) and Kerr Hollow Quarry (KHQ), and RCRA post-closure corrective action groundwater monitoring at the Chestnut Ridge Security Pits (CRSPs). Modification of these PCP conditions is requested to: (1) clarify the planned integration of RCRA post-closure corrective action groundwater monitoring at the CRSPs with the monitoring program to be established in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) record of decision (ROD), (2) revise several of the current technical requirements for groundwater monitoring based on implementation of the RCRA monitoring programs during 1996, (3) replace several of the technical procedures included in the PCP with updated versions recently issued by the Y-12 Plant Groundwater Protection Program (GWPP), and (4) correct inaccurate regulatory citations and references to permit conditions and permit attachments. With these modifications, the Y- 12 Plant will continue to meet the full intent of all regulatory obligations for post-closure care of these facilities. Section 2 provides the technical justification for each proposed permit modification. Section 3.0 contains proposed changes to Section II of the PCP. Modifications to site-specific permit conditions are presented in Section 4.0 (CRSDB), Section 5.0 (CRSPs), and Section 6.0 (KHQ). Sections 7.0 and 8.0 reference updated and revised procedures for groundwater sampling, and monitoring well plugging and abandonment, respectively. Appendix A includes all proposed revisions to the permit attachments.

  11. Evaluation of models proposed for the 1991 revision of the International Geomagnetic Reference Field

    USGS Publications Warehouse

    Peddie, N.W.

    1992-01-01

    The 1991 revision of the International Geomagnetic Reference Field (IGRF) comprises a definitive main-field model for 1985.0, a main-field model for 1990.0, and a forecast secular-variation model for the period 1990-1995. The five 1985.0 main-field models and five 1990.0 main-field models that were proposed have been evaluated by comparing them with one another, with magnetic observatory data, and with Project MAGNET aerial survey data. The comparisons indicate that the main-field models proposed by IZMIRAN, and the secular-variation model proposed jointly by the British Geological Survey and the US Naval Oceanographic Office, should be assigned relatively lower weight in the derivation of the new IGRF models. -Author

  12. Final technical evaluation report for the proposed revised reclamation plan for the Atlas Corporation Moab Mill

    SciTech Connect

    1997-03-01

    This final Technical Evaluation Report (TER) summarizes the US Nuclear Regulatory Commission staff`s review of Atlas Corporation`s proposed reclamation plan for its uranium mill tailings pile near Moab, Utah. The proposed reclamation would allow Atlas to (1) reclaim the tailings pile for permanent disposal and long-term custodial care by a government agency in its current location on the Moab site, (2) prepare the site for closure, and (3) relinquish responsibility of the site after having its NRC license terminated. The NRC staff concludes that, subject to license conditions identified in the TER, the proposed reclamation plan meets the requirements identified in NRC regulations, which appear primarily in 10 CFR Part 40. 112 refs., 6 figs., 16 tabs.

  13. Fertility Modification Thesaurus with Focus on Evaluation of Family Planning Programs.

    ERIC Educational Resources Information Center

    Speert, Kathryn H.; Wishik, Samuel M.

    The Division of Social and Administrative Sciences of the International Institute for the Study of Human Reproduction at Columbia University has compiled this list of terms used in indexing the literature for family planning program evaluation. This thesaurus should prove of direct use to the indexer of documents describing family planning program…

  14. Design and Evaluation of Modifications to the NASA Langley Flow Impedance Tube

    NASA Technical Reports Server (NTRS)

    Jones, Michael G.; Watson, Willie R.; Parrott, Tony L.; Smith, Charles D.

    2004-01-01

    The need to minimize fan noise radiation from commercial aircraft engine nacelles continues to provide an impetus for developing new acoustic liner concepts. If the full value of such concepts is to be attained, an understanding of grazing flow effects is crucial. Because of this need for improved understanding of grazing flow effects, the NASA Langley Research Center Liner Physics Group has invested a large effort over the past decade into the development of a 2-D finite element method that characterizes wave propagation through a lined duct. The original test section in the Langley Grazing IncidenceTube was used to acquire data needed for implementation of this finite element method. This test section employed a stepper motor-driven axial-traversing bar, embedded in the wall opposite the test liner, to position a flush-mounted microphone at pre-selected locations. Complex acoustic pressure data acquired with this traversing microphone were used to educe the acoustic impedance of test liners using this 2-D finite element method and a local optimization technique. Results acquired in this facility have been extensively reported, and were compared with corresponding results from various U.S. aeroacoustics laboratories in the late 1990 s. Impedance data comparisons acquired from this multi-laboratory study suggested that it would be valuable to incorporate more realistic 3-D aeroacoustic effects into the impedance eduction methodology. This paper provides a description of modifications that have been implemented to facilitate studies of 3-D effects. The two key features of the modified test section are (1) the replacement of the traversing bar and its flush-mounted microphone with an array of 95 fixed-location microphones that are flush-mounted in all four walls of the duct, and (2) the inclusion of a suction device to modify the boundary layer upstream of the lined portion of the duct. The initial results achieved with the modified test section are provided in this

  15. Evaluation of possible temperature fluctuations from proposed power modifications at hoover dam. Technical report no. 3 (final)

    SciTech Connect

    Baker, J.R.; Paulson, L.J.

    1980-01-01

    The U.S. Bureau of Reclamation is considering several alternatives for modifying Hoover Dam's existing hydroelectric facilities or adding new facilities in the Lake Mead Recreation Area to increase peak-power output. This specific report is to determine to what extent discharge temperature from Hoover Dam and thermal stratification in Lake Mead would chance with discharges under the following conditions: (1) all four intakes on the upper gates (2) all four intakes on the lower gates and (3) from a combined use of one upper gate and four lower gates.

  16. Evaluation of dredged material proposed for ocean Disposal from Shoal Harbor/Compton Creek Project Area

    SciTech Connect

    Gardiner, W.W.; Borde, A.B.; Nieukirk, S.L.; Barrows, E.S.; Gruendell, B.D.; Word, J.Q.

    1996-10-01

    The objective of the Shoal Harbor/Compton Creek Project was to evaluate proposed dredged material from the Shoal harbor/Compton Creek Project Area in Belford and Monmouth, New Jersey to determine its suitability for unconfined ocean disposal at the Mud Dump Site. This was one of five waterways that the US Army Corps of Engineers- New York District requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in May 1995. The evaluation of proposed dredged material from the Shoal Harbor/Compton Creek Project area consisted of bulk chemical analyses, chemical analyses of dredging site water and elutriate, benthic and water-column acute toxicity tests and bioaccumulation studies. Eleven core samples were analyzed or grain size, moisture content, and total organic carbon. Other sediments were evaluated for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Dredging site water and elutriate water were analyzed for metals, pesticides, and PCBs.

  17. Permit application modifications

    SciTech Connect

    1995-11-01

    This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils.

  18. Evaluation and Analysis of the ANSI X3T9.5 (FDDI) PMD and Proposed SMF-PMD as Influenced by Various Fiber Link Characteristics

    NASA Technical Reports Server (NTRS)

    Wernicki, M. Chris

    1991-01-01

    The purpose of this project is to evaluate the operational parameters of the Kennedy Space Center (KSC) fiber optic cable plant. The evaluation is based on the Fiber Distributed Data Interface (FDDI) Physical Medium Dependent (PMD) and Single Mode Fiber (SMF) PMD standards. From the KSC fiber profile, it would be necessary to develop the modifications needed in existing FDDI PMD and proposed SMF-PMD standards to provide for FDDI implementation and operation at KSC. This analysis should examine the major factors that influence the operating conditions of the KSC fiber plant. These factors would include, but are not limited to the number and type of connectors, attenuation and dispersion characteristics of the fiber, non-standard fiber sizes, modal bandwidth, and many other relevant or significant fiber plant characteristics that effect FDDI characteristics. This analysis is needed to gain a better understanding of overall impact that each of these factors have on FDDI performance at KSC.

  19. Evaluation of dredged material proposed for ocean disposal from Westchester Creek project area, New York

    SciTech Connect

    Pinza, M.R.; Gardiner, W.W.; Barrows, E.S.; Borde, A.B.

    1996-11-01

    The objective of the Westchester Creek project was to evaluate proposed dredged material from this area to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Westchester Creek was one of five waterways that the US Army Corps of Engineers- New York District (USACE-NYD) requested the Battelle/Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in May 1995. The evaluation of proposed dredged material from the Westchester Creek project area consisted of bulk sediment chemical analyses, chemical analyses of dredging site water and elutriate, benthic acute and water-column toxicity tests, and bioaccumulation studies. Thirteen individual sediment core samples were collected from this area and analyzed for grain size, moisture content, and total organic carbon (TOC). One composite sediment sample representing the Westchester Creek area to be dredged, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4-dichlorobenzene. Dredging site water and elutriate water, which is prepared from the suspended- particulate phase (SPP) of the Westchester Creek sediment composite, was analyzed for metals, pesticides, and PCBS.

  20. A method proposal for cumulative environmental impact assessment based on the landscape vulnerability evaluation

    SciTech Connect

    Pavlickova, Katarina; Vyskupova, Monika

    2015-01-15

    Cumulative environmental impact assessment deals with the occasional use in practical application of environmental impact assessment process. The main reasons are the difficulty of cumulative impact identification caused by lack of data, inability to measure the intensity and spatial effect of all types of impacts and the uncertainty of their future evolution. This work presents a method proposal to predict cumulative impacts on the basis of landscape vulnerability evaluation. For this purpose, qualitative assessment of landscape ecological stability is conducted and major vulnerability indicators of environmental and socio-economic receptors are specified and valuated. Potential cumulative impacts and the overall impact significance are predicted quantitatively in modified Argonne multiple matrixes while considering the vulnerability of affected landscape receptors and the significance of impacts identified individually. The method was employed in the concrete environmental impact assessment process conducted in Slovakia. The results obtained in this case study reflect that this methodology is simple to apply, valid for all types of impacts and projects, inexpensive and not time-consuming. The objectivity of the partial methods used in this procedure is improved by quantitative landscape ecological stability evaluation, assignment of weights to vulnerability indicators based on the detailed characteristics of affected factors, and grading impact significance. - Highlights: • This paper suggests a method proposal for cumulative impact prediction. • The method includes landscape vulnerability evaluation. • The vulnerability of affected receptors is determined by their sensitivity. • This method can increase the objectivity of impact prediction in the EIA process.

  1. Evaluation of dredged material proposed for ocean disposal from South Brother Island Channel, New York

    SciTech Connect

    Barrows, E.S.; Gardiner, W.W.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-09-01

    South Brother Island Channel was one of seven waterways that the US Army Crops of Engineers-New York District requested the Battelle/Marine Sciences Laboratory to sample and evaluate for dredging and disposal. Tests and analyses were conducted on South Brother Island Channel sediment core samples and evaluations were performed. The evaluation of proposed dredged material from South Brother Island Channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Souther Brother Island Channel were analyzed for grain size, moisture content, and total organic carbon. a composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Site water and elutriate water, prepared from the suspended-particle phase of South Brother Island Channel sediment, were analyzed for metals, pesticides, and PCBs.

  2. Ecological evaluation of proposed dredged material from the Point Frazer Bend Reach, Winyah Bay, South Carolina

    SciTech Connect

    Gardiner, W.W.; Ward, J.A.; Word, J.Q.

    1995-02-01

    The port of Georgetown, South Carolina, is served by navigational channels within Winyah Bay and the lower Sampit River. Dredging is required to maintain these waterways and to facilitate normal shipping traffic. Prior to dredging, ecological evaluations must be conducted to determine the suitability of the proposed dredged material for open-ocean disposal. These evaluations are to be performed under Section 103 of the Marine Protection, Research, and, Sanctuaries Act of 1972 (MPRSA), following the testing protocols presented in Evaluation of Dredged Material Proposed for Ocean Disposal Testing Manual, hereafter referred to as the 1991 Implementation Manual. The Charleston Intensive Project is a reevaluation of sediments collected from two stations (IH-2 and IH-3) in the Frazier Point Bend reach of the Winyah Bay channel. Reference sediment was also collected from site IH-R2, just south of Hare Island. The results of physical/chemical analyses indicated that some contaminants of concern were present in test treatments representing dredged material when compared with the reference treatment IH-R2. The results of this study indicate that, based on the acute toxicity and chemical analyses, dredged material represented by these test treatments is suitable for open-ocean disposal.

  3. Evaluating Academic Scientists Collaborating in Team-Based Research: A Proposed Framework.

    PubMed

    Mazumdar, Madhu; Messinger, Shari; Finkelstein, Dianne M; Goldberg, Judith D; Lindsell, Christopher J; Morton, Sally C; Pollock, Brad H; Rahbar, Mohammad H; Welty, Leah J; Parker, Robert A

    2015-10-01

    Criteria for evaluating faculty are traditionally based on a triad of scholarship, teaching, and service. Research scholarship is often measured by first or senior authorship on peer-reviewed scientific publications and being principal investigator on extramural grants. Yet scientific innovation increasingly requires collective rather than individual creativity, which traditional measures of achievement were not designed to capture and, thus, devalue. The authors propose a simple, flexible framework for evaluating team scientists that includes both quantitative and qualitative assessments. An approach for documenting contributions of team scientists in team-based scholarship, nontraditional education, and specialized service activities is also outlined. Although biostatisticians are used for illustration, the approach is generalizable to team scientists in other disciplines.The authors offer three key recommendations to members of institutional promotion committees, department chairs, and others evaluating team scientists. First, contributions to team-based scholarship and specialized contributions to education and service need to be assessed and given appropriate and substantial weight. Second, evaluations must be founded on well-articulated criteria for assessing the stature and accomplishments of team scientists. Finally, mechanisms for collecting evaluative data must be developed and implemented at the institutional level. Without these three essentials, contributions of team scientists will continue to be undervalued in the academic environment. PMID:25993282

  4. Hyperthermic tissue sealing devices: a proposed histopathologic protocol for standardizing the evaluation of thermally sealed vessels

    NASA Astrophysics Data System (ADS)

    Livengood, Ryan H.; Vos, Jeffrey A.; Coad, James E.

    2011-03-01

    Hyperthermic tissue sealing devices are advancing modern laparoscopy and other minimally invasive surgical approaches. Histopathologic evaluation of thermally sealed vessels can provide important information on their associated tissue effects and reactions. However, a standardized systematic approach has not been historically used in the literature. This paper proposes a histologic approach for the analysis of thermally sealed vessels and their basis of hemostasis, including thermal tissue changes, healing, and thrombosis. Histologic evaluation during the first week (Days 3-7) can assess the seal's primary tissue properties. These parameters include the thermal seal's length, architecture, tissue layers involved, adventitial collagen denaturation length, entrapped vapor or blood pockets, tissue homogenization and thermal tissue injury zones. While the architectural features can be assessed in Day 0-3 specimens, the latter thermal injury zones are essentially not assessable in Day 0-3 specimens. Day 14 specimens can provide information on the early healing response to the sealed vessel. Day 30 and longer specimens can be used to evaluate the seal's healing reactions. Assessment of the healing response should include seal site inflammation, granulation tissue, necrosis resorption, fibroproliferative scar healing, and thrombus organization. In order to accurately evaluate these parameters, careful specimen orientation, embedding and multiple histologic sections across the entire seal width are required. When appropriate in vivo post-treatment times are used, thermal vessel seals can be evaluated with routine light microscopy and common histologic staining methods.

  5. Evaluating Academic Scientists Collaborating in Team-Based Research: A Proposed Framework.

    PubMed

    Mazumdar, Madhu; Messinger, Shari; Finkelstein, Dianne M; Goldberg, Judith D; Lindsell, Christopher J; Morton, Sally C; Pollock, Brad H; Rahbar, Mohammad H; Welty, Leah J; Parker, Robert A

    2015-10-01

    Criteria for evaluating faculty are traditionally based on a triad of scholarship, teaching, and service. Research scholarship is often measured by first or senior authorship on peer-reviewed scientific publications and being principal investigator on extramural grants. Yet scientific innovation increasingly requires collective rather than individual creativity, which traditional measures of achievement were not designed to capture and, thus, devalue. The authors propose a simple, flexible framework for evaluating team scientists that includes both quantitative and qualitative assessments. An approach for documenting contributions of team scientists in team-based scholarship, nontraditional education, and specialized service activities is also outlined. Although biostatisticians are used for illustration, the approach is generalizable to team scientists in other disciplines.The authors offer three key recommendations to members of institutional promotion committees, department chairs, and others evaluating team scientists. First, contributions to team-based scholarship and specialized contributions to education and service need to be assessed and given appropriate and substantial weight. Second, evaluations must be founded on well-articulated criteria for assessing the stature and accomplishments of team scientists. Finally, mechanisms for collecting evaluative data must be developed and implemented at the institutional level. Without these three essentials, contributions of team scientists will continue to be undervalued in the academic environment.

  6. Mass casualty triage: an evaluation of the data and development of a proposed national guideline.

    PubMed

    Lerner, E Brooke; Schwartz, Richard B; Coule, Phillip L; Weinstein, Eric S; Cone, David C; Hunt, Richard C; Sasser, Scott M; Liu, J Marc; Nudell, Nikiah G; Wedmore, Ian S; Hammond, Jeffrey; Bulger, Eileen M; Salomone, Jeffrey P; Sanddal, Teri L; Markenson, David; O'Connor, Robert E

    2008-09-01

    Mass casualty triage is a critical skill. Although many systems exist to guide providers in making triage decisions, there is little scientific evidence available to demonstrate that any of the available systems have been validated. Furthermore, in the United States there is little consistency from one jurisdiction to the next in the application of mass casualty triage methodology. There are no nationally agreed upon categories or color designations. This review reports on a consensus committee process used to evaluate and compare commonly used triage systems, and to develop a proposed national mass casualty triage guideline. The proposed guideline, entitled SALT (sort, assess, life-saving interventions, treatment and/or transport) triage, was developed based on the best available science and consensus opinion. It incorporates aspects from all of the existing triage systems to create a single overarching guide for unifying the mass casualty triage process across the United States.

  7. Evaluation of dredged material proposed for ocean disposal from Arthur Kill Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Barrows, E.S.; Borde, A.B.

    1997-01-01

    The objective of the bioassay reevaluation of Arthur Kill Federal Project was to reperform toxicity testing on proposed dredged material following current ammonia reduction protocols. Arthur Kill was one of four waterways sampled and evaluated for dredging and disposal in April 1993. Sediment samples were recollected from the Arthur Kill Project areas in August 1995. Tests and analyses were conducted according to the manual developed by the USACE and the U.S. Environmental Protection Agency (EPA), Evaluation of Dredged Material Proposed for Ocean Disposal (Testing Manual), commonly referred to as the {open_quotes}Green Book,{close_quotes} and the regional manual developed by the USACE-NYD and EPA Region II, Guidance for Performing Tests on Dredged Material to be Disposed of in Ocean Waters. The reevaluation of proposed dredged material from the Arthur Kill project areas consisted of benthic acute toxicity tests. Thirty-three individual sediment core samples were collected from the Arthur Kill project area. Three composite sediments, representing each reach of the area proposed for dredging, was used in benthic acute toxicity testing. Benthic acute toxicity tests were performed with the amphipod Ampelisca abdita and the mysid Mysidopsis bahia. The amphipod and mysid benthic toxicity test procedures followed EPA guidance for reduction of total ammonia concentrations in test systems prior to test initiation. Statistically significant acute toxicity was found in all Arthur Kill composites in the static renewal tests with A. abdita, but not in the static tests with M. bahia. Statistically significant acute toxicity and a greater than 20% increase in mortality over the reference sediment was found in the static renewal tests with A. abdita. M. bahia did not show statistically significant acute toxicity or a greater than 10% increase in mortality over reference sediment in static tests. 5 refs., 2 figs., 2 tabs.

  8. Evaluation of dredged material proposed for ocean disposal from Hackensack River Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Barrows, E.S.; Borde, A.B.

    1997-01-01

    The objective of the bioassay reevaluation of the Hackensack River Federal Project was to reperform toxicity testing on proposed dredged material with current ammonia reduction protocols. Hackensack River was one of four waterways sampled and evaluated for dredging and disposal in April 1993. Sediment samples were re-collected from the Hackensack River Project area in August 1995. Tests and analyses were conducted according to the manual developed by the USACE and the U.S. Environmental Protection Agency (EPA), Evaluation of Dredged Material Proposed for Ocean Disposal (Testing Manual), commonly referred to as the {open_quotes}Green Book,{close_quotes} and the regional manual developed by the USACE-NYD and EPA Region II, Guidance for Performing Tests on Dredged Material to be Disposed of in Ocean Waters. The reevaluation of proposed dredged material from the Hackensack River project area consisted of benthic acute toxicity tests. Thirty-three individual sediment core samples were collected from the Hackensack River project area. Three composite sediments, representing each reach of the area proposed for dredging, were used in benthic acute toxicity testing. Benthic acute toxicity tests were performed with the amphipod Ampelisca abdita and the mysid Mysidopsis bahia. The amphipod and mysid benthic toxicity test procedures followed EPA guidance for reduction of total ammonia concentrations in test systems prior to test initiation. Statistically significant acute toxicity was found in all three Hackensack River composites in the static renewal tests with A. abdita, but not in the static tests with M. bahia. Statistically significant acute toxicity and a greater than 20% increase in mortality over the reference sediment was found in the static renewal tests with A. abdita. Statistically significant mortality 10% over reference sediment was observed in the M. bahia static tests. 5 refs., 2 figs., 2 tabs.

  9. Evaluation of dredged material proposed for ocean disposal from Eastchester Project Area, New York

    SciTech Connect

    Antrim, L.D.; Pinza, M.R.; Barrows, E.S.; Gardiner, W.W.; Tokos, J.J.S.; Gruendell, B.D.; Word, J.Q.

    1996-07-01

    The objective of the Eastchester project (Federal Project [FP] No. 6) was to evaluate proposed dredged material from the Eastchester project area in the Hutchinson River to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Eastchester was one of seven waterways that the U. S. Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle/Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in March 1994. The evaluation of proposed dredged material from the Eastchester project area consisted of bulk sediment chemical analyses, chemical analyses of dredging site water and elutriate, water- column and benthic acute toxicity tests, and bioaccumulation studies. Eighteen individual sediment core samples collected from the Eastchester project area were analyzed for grain size, moisture content, and total organic carbon (TOC). Two composite sediment samples, representing the upstream and lower reaches of the area proposed for dredging, were analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4- dichlorobenzene. Dredging site water and elutriate water, which is prepared from the suspended-particulate phase (SPP) of the two Eastchester sediment composites, were analyzed for metals, pesticides, and PCBS. An additional 1 1 composite samples were created for the USACE-New England Division (USACE-NED) using the same 18 Eastchester core samples but combined into different composites. These composites were analyzed for metals, chlorinated pesticides, PCB congeners, PAHS, and 1,4-dichlorobenzene. Water-column or SPP toxicity tests were performed along with bioaccumulation tests.

  10. Evaluation of the proposed pilot groundwater pump and treat demonstration for the Paducah Gaseous Diffusion Plant

    SciTech Connect

    Bodenstein, G.W.; Bonczek, R.R.; Early, T.O.; Hale, T.B.; Huff, D.D.; Nickelson, M.D.; Rightmire, C.T.

    1992-11-01

    This report contains the evaluation and recommendations of a Groundwater Corrective Actions Review Team. The primary goal is to evaluate the technical merit of and the need to implement a proposed groundwater pump-and-treat demonstration project for the Northwest contaminant plume at Paducah, Kentucky. A key distinction recognized by the review team is that the proposed project is intended to be a full-scale hydraulic containment of contaminants migrating from the sources of the plume, not plume remediation. The key questions incorporated into this plan are whether (1) dense, nonaqueous-phase liquids (DNAPLS) are present in the Regional Gravel Aquifer (RGA) at the source of the plume and (2) [sup 99]Tc removal must be included as part of any groundwater treatment process. The first question cannot be answered until the contaminant sources are better defined; the second question requires further risk assessment and/or a policy decision by DOE. Technical evaluation by the review team suggests that the recommended course of action be to modify the proposed work plan to include accurate identification of the sources of contaminants and vertical distribution of contaminants within the Northwest plume before a decision is made on the preferred source-control option. If DNAPLs are not present in the RGA, removal or containment of the sources is recommended. If DNAPLs are present, then hydraulic containment will be required. Finally, the review team recognizes that it is necessary to initiate a more comprehensive analysis of sitewide remediation needs to create links between action taken for the Northwest plume and action taken for other contamination sites at PGPD.

  11. A Quick Method for Evaluating the Merits of a Proposed Low Sonic Boom Concept

    NASA Technical Reports Server (NTRS)

    Mack, Robert J.

    2003-01-01

    The characteristics of a proposed low-boom aircraft concept cannot be adequately assessed unless it is given an extensive, time-consuming, mission-performance, and sonic-boom analyses. So, it would be useful to have a method for performing a quick first-order sonic-boom and mission-range analysis. The evaluation method outlined in this report has the attributes of being both fast and reasonably accurate. It can also be used as a design tool to estimate the sonic-boom ground overpressures, mission range, and beginning-cruise weight of a new low-boom concept during the first stages of preliminary design.

  12. A proposal for the curriculum and evaluation for training rural family physicians in enhanced surgical skills

    PubMed Central

    Caron, Nadine; Iglesias, Stuart; Friesen, Randall; Berjat, Vanessa; Humber, Nancy; Falk, Ryan; Prins, Mark; Haines, Victoria Vogt; Geller, Brian; Janke, Fred; Woollard, Robert; Batchelor, Bret; Van Bussel, Jared

    2015-01-01

    Summary Rural western Canada relies heavily on family physicians with enhanced surgical skills (ESS) for surgical services. The recent decision by the College of Family Physicians of Canada (CFPC) to recognize ESS as a “community of practice” section offers a potential home akin to family practice anesthesia and emergency medicine. To our knowledge, however, a skill set for ESS in Canada has never been described formally. In this paper the Curriculum Committee of the National ESS Working Group proposes a generic curriculum for the training and evaluation of the ESS skill set. PMID:26574835

  13. Ecological evaluation of proposed dredged material from Winyah Bay, South Carolina

    SciTech Connect

    Ward, J.A.; Gardiner, W.W.; Pinza, M.R.; Word, J.Q.

    1993-10-01

    The navigational channels of Winyah Bay, Georgetown Harbor, South Carolina require dredging to enable normal shipping traffic to use these areas. Before dredging, environmental assessments must be conducted to determine the suitability of this dredged sediment for unconfined, open-water disposal. The Charleston, South Carolina District Office of the US Army Corps of Engineers (USACE) requested that the Battelle/Marine Science Laboratory (MSL) collect sediment samples and conduct the required physical/chemical, toxicological, and bioaccumulation evaluations as required in the 1991 Implementation Manual. This report is intended to provide information required to address potential ecological effects of the Entrance Channel and Inner Harbor sediments proposed disposal in the ocean.

  14. Rat white matter injury model induced by endothelin-1 injection: technical modification and pathological evaluation.

    PubMed

    Ono, Hideaki; Imai, Hideaki; Miyawaki, Satoru; Nakatomi, Hirofumi; Saito, Nobuhito

    2016-01-01

    White matter injury is an important cause of functional disability of the brain. We comprehensively analyzed a modified endothelin-1 (ET‑1) injection-induced white matter injury model in the rat which is very valuable for investigating the underlying mechanisms of subcortical ischemic stroke. ET-1 was stereotactically injected into the internal capsule of the rat. To avoid complications with leakage of ET-1 into the lateral ventricle, the safest trajectory angle to the target was established. Rats with white matter injury were extensively evaluated for structural changes and functional sequelae, using motor function tests, magnetic resonance (MR) imaging, histopathology evolution, volume estimation of the lesion, and neuroanatomical identification of affected neurons using the retrograde tracer hydroxystilbamidine. Optimization of the trajectory of the ET-1 injection needle provided excellent survival rate. MR imaging visualized the white matter injury 2 days after surgery. Motor function deficit appeared temporarily after the operation. Histological studies confirmed damage of axons and myelin sheaths followed by inflammatory reaction and gliosis similar to lacunar infarction, with lesion volume of less than 1% of the whole brain. Hydroxystilbamidine injected into the lesion revealed wide spatial distribution of the affected neuronal population. Compared with prior ET-1 injection models, this method induced standardized amount of white matter damage and temporary motor function deficit in a reproducible and safe manner. The present model is valuable for studying the pathophysiology of not only ischemia, but a broader set of white matter damage conditions in the lissencephalic brain. PMID:27685774

  15. Evaluation of Surface Modification as a Lunar Dust Mitigation Strategy for Thermal Control Surfaces

    NASA Technical Reports Server (NTRS)

    Gaier, James R.; Waters, Deborah L.; Misconin, Robert M.; Banks, Bruce A.; Crowder, Mark

    2011-01-01

    Three surface treatments were evaluated for their ability to lower the adhesion between lunar simulant dust and AZ93, AlFEP, and AgFEP thermal control surfaces under simulated lunar conditions. Samples were dusted in situ and exposed to a standardized puff of nitrogen gas. Thermal performance before dusting, after dusting, and after part of the dust was removed by the puff of gas, were compared to perform the assessment. None of the surface treatments was found to significantly affect the adhesion of lunar simulants to AZ93 thermal control paint. Oxygen ion beam texturing also did not lower the adhesion of lunar simulant dust to AlFEP or AgFEP. But a workfunction matching coating and a proprietary Ball Aerospace surface treatment were both found to significantly lower the adhesion of lunar simulants to AlFEP and AgFEP. Based on these results, it is recommended that all these two techniques be further explored as dust mitigation coatings for AlFEP and AgFEP thermal control surfaces.

  16. Modifications of in vitro skin penetration under solar irradiation: evaluation on flow-through diffusion cells.

    PubMed

    Gélis, Christelle; Mavon, Alain; Delverdier, Maxence; Paillous, Nicole; Vicendo, Patricia

    2002-06-01

    The effect of solar irradiation on ex vivo dermatomed hairless rat skin samples maintained in culture on flow-through diffusion cells for at least 24 h was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and by histological observations. Transepidermal water loss (TEWL) measurements and kinetic analysis of the permeation of both tritiated water and 14C caffeine through the skin were performed after full-spectrum solar exposure involving the use of a xenon arc solar simulator. After a UV exposure of less than 420 mJ/cm2, skin integrity and permeation of both water and caffeine did not change significantly. In contrast, after a 420 mJ/cm2 UV exposure, the epidermis appeared more contracted, associated with an increase of 55% of TEWL and 220% of the skin permeation of tritiated water after 6 h. The data suggested a dramatic alteration of the skin barrier integrity. Moreover, the flux of 14C caffeine increased rapidly by 338% of the absorption of water 12 h after irradiation. These results reveal the presence of a threshold UV exposure that would not modify skin penetration.

  17. 22 CFR 225.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 225.120 Section 225... Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. The department or agency head will evaluate all applications and...

  18. 7 CFR 1c.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 1c.120 Section 1c.120... disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The department or agency head will evaluate all applications and proposals involving...

  19. 15 CFR 27.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... applications and proposals for research to be conducted or supported by a Federal Department or Agency. 27.120... § 27.120 Evaluation and disposition of applications and proposals for research to be conducted or... applications and proposals involving human subjects submitted to the department or agency through such...

  20. 49 CFR 11.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 11.120 Section 11.120... disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. The department or agency head will evaluate all applications and proposals involving...

  1. 28 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... applications and proposals for research to be conducted or supported by a Federal Department or Agency. 46.120....120 Evaluation and disposition of applications and proposals for research to be conducted or supported... and proposals involving human subjects submitted to the department or agency through such officers...

  2. 16 CFR 1028.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and proposals for research to be conducted or supported by a Federal Department or Agency. 1028.120... SUBJECTS § 1028.120 Evaluation and disposition of applications and proposals for research to be conducted... applications and proposals involving human subjects submitted to the department or agency through such...

  3. Evaluation of dredged material proposed for ocean disposal from Bronx River Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Gardiner, W.W.; Antrim, L.D.; Pinza, M.R.; Barrows, E.S.; Borde, A.B.

    1996-12-01

    The objective of the Bronx River project was to evaluate proposed dredged material from the Bronx River project area in Bronx, New York, to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Bronx River was one of five waterways that the US Army Corps of Engineers-New York District (USAGE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and to evaluate for dredging and disposal. Sediment samples were submitted for physical and chemical analyses, chemical analyses of dredging site water and elutriate, benthic and water-column acute toxicity tests, and bioaccumulation studies. Fifteen individual sediment core samples collected from the Bronx River project area were analyzed for grain size, moisture content, and total organic carbon (TOC). One composite sediment sample, representing the entire reach of the area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4- dichlorobenzene. Dredging site water and elutriate water, which was prepared from the suspended-particulate phase (SPP) of the Bronx River sediment composite, were analyzed for metals, pesticides, and PCBS.

  4. Evaluation of dredged material proposed for ocean disposal from Hudson River, New York

    SciTech Connect

    Gardiner, W.W.; Barrows, E.S.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-09-01

    The Hudson River (Federal Project No. 41) was one of seven waterways that the U.S. Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in March 1994. Sediment samples were collected from the Hudson River. Tests and analyses were conducted on Hudson River sediment core samples. The evaluation of proposed dredged material from the Hudson River included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Hudson River were analyzed for grain size, moisture content, and total organic carbon (TOC). A composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4-dichlorobenzene. Site water and elutriate water, prepared from the suspended-particulate phase (SPP) of Hudson River sediment, were analyzed for metals, pesticides, and PCBS. Water-column or SPP toxicity tests were performed with three species. Benthic acute toxicity tests were performed. Bioaccumulation tests were also conducted.

  5. Evaluating Cloud Computing in the Proposed NASA DESDynI Ground Data System

    NASA Technical Reports Server (NTRS)

    Tran, John J.; Cinquini, Luca; Mattmann, Chris A.; Zimdars, Paul A.; Cuddy, David T.; Leung, Kon S.; Kwoun, Oh-Ig; Crichton, Dan; Freeborn, Dana

    2011-01-01

    The proposed NASA Deformation, Ecosystem Structure and Dynamics of Ice (DESDynI) mission would be a first-of-breed endeavor that would fundamentally change the paradigm by which Earth Science data systems at NASA are built. DESDynI is evaluating a distributed architecture where expert science nodes around the country all engage in some form of mission processing and data archiving. This is compared to the traditional NASA Earth Science missions where the science processing is typically centralized. What's more, DESDynI is poised to profoundly increase the amount of data collection and processing well into the 5 terabyte/day and tens of thousands of job range, both of which comprise a tremendous challenge to DESDynI's proposed distributed data system architecture. In this paper, we report on a set of architectural trade studies and benchmarks meant to inform the DESDynI mission and the broader community of the impacts of these unprecedented requirements. In particular, we evaluate the benefits of cloud computing and its integration with our existing NASA ground data system software called Apache Object Oriented Data Technology (OODT). The preliminary conclusions of our study suggest that the use of the cloud and OODT together synergistically form an effective, efficient and extensible combination that could meet the challenges of NASA science missions requiring DESDynI-like data collection and processing volumes at reduced costs.

  6. Evaluation of the streamflow-gaging network of Texas and a proposed core network

    USGS Publications Warehouse

    Slade, R.M.; Howard, Teresa; Anaya, Roberto

    2001-01-01

    The U.S. Geological Survey streamflowgaging network in Texas is operated as part of the National Streamgaging Program and is jointly funded by the Geological Survey and Federal, State, and local agencies. This report documents an evaluation of the existing (as of October 1, 1999) network with regard to four major objectives of streamflow data; and on the basis of that evaluation, proposes a core network of streamflowgaging stations that best meets those objectives. The objectives are (1) regionalization (estimate flows or flow characteristics at ungaged sites in 11 hydrologically similar regions), (2) major flow (obtain flow rates and volumes in large streams), (3) outflow from the State (account for streamflow leaving the State), and (4) streamflow conditions assessment (assess current conditions with regard to long-term data, and define temporal trends in flow). The network analysis resulted in a proposed core network of 263 stations. Of those 263 stations, 43 were discontinued as of October 1, 1999, and 15 were partial-record stations. Fifty-five of the proposed core-network stations meet two of the four major objectives, 16 stations meet three objectives, and 1 station meets all four. One-hundred eighty-five stations with a median record length of 33 years were selected to meet the regionalization objective. Ninety-two stations with a median record length of about 62 years were selected to meet the major-flow objective. Twenty-six stations with a median record length of 59 years were selected to meet the outflow from the State objective. Fifty stations with a median record length of 53 years were selected to meet the streamflow conditions assessment objective.

  7. [Empirical standard costs for health economic evaluation in Germany -- a proposal by the working group methods in health economic evaluation].

    PubMed

    Krauth, C; Hessel, F; Hansmeier, T; Wasem, J; Seitz, R; Schweikert, B

    2005-10-01

    Measurement of health care costs is a crucial task in health economic evaluation. Various guidelines with different amount of details have been set up for costing methods in economic evaluation which, however, do not precisely stipulate how to value resource consumption. In this article we present a proposal for the standardisation of the monetary valuation of health care utilisation occurring in the follow up period after the actual intervention to be evaluated. From a societal perspective the primary direct and indirect cost components are considered, such as outpatient medical care, pharmaceuticals, non-physician health services, inpatient care, days of sick leave and early retirement due to sickness. The standard costs are based on administrative charges and rates or on official statistics. They are based on the most current data sources which are mainly from 2002 and 2003. This system of standard costs aims at an average valuation of resource consumption. This makes for the comparability of different health economic studies. Most standard costs are not based on market prices but on administratively specified charges and rates. This implies that institutional changes which are quite common in the health care system, may also affect the valuation rates, for example the introduction of DRGs. This should be taken into account when updating the system of standard costs.

  8. ARSENIC REMOVAL FROM DRINKING WATER BY PROCESS MODIFICATION TO COAGULATION/FILTRATION. USEPA DEMONSTRATION PROJECT AT LIDGERWOOD, ND. FINAL PERFORMANCE EVALUATION REPORT

    EPA Science Inventory

    This report documents the activities performed and the results obtained for the arsenic removal treatment technology demonstration project at the Lidgerwood, North Dakota site. The objectives of the project were to evaluate: (1) the effectiveness of process modifications to an e...

  9. 75 FR 65700 - 60-Day Notice of Proposed Information Collection: R/PPR Evaluation and Measurement Unit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... Notice of Proposed Information Collection: R/PPR Evaluation and Measurement Unit, Evaluation Survey... of Information Collection: R/PPR Evaluation and Measurement Unit Survey Question Bank. OMB Control... Unit (R/PPR EMU). Form Number: Survey numbers generated as needed. Respondents: Participants in...

  10. Visual privacy by context: proposal and evaluation of a level-based visualisation scheme.

    PubMed

    Padilla-López, José Ramón; Chaaraoui, Alexandros Andre; Gu, Feng; Flórez-Revuelta, Francisco

    2015-06-04

    Privacy in image and video data has become an important subject since cameras are being installed in an increasing number of public and private spaces. Specifically, in assisted living, intelligent monitoring based on computer vision can allow one to provide risk detection and support services that increase people's autonomy at home. In the present work, a level-based visualisation scheme is proposed to provide visual privacy when human intervention is necessary, such as at telerehabilitation and safety assessment applications. Visualisation levels are dynamically selected based on the previously modelled context. In this way, different levels of protection can be provided, maintaining the necessary intelligibility required for the applications. Furthermore, a case study of a living room, where a top-view camera is installed, is presented. Finally, the performed survey-based evaluation indicates the degree of protection provided by the different visualisation models, as well as the personal privacy preferences and valuations of the users.

  11. Visual Privacy by Context: Proposal and Evaluation of a Level-Based Visualisation Scheme

    PubMed Central

    Padilla-López, José Ramón; Chaaraoui, Alexandros Andre; Gu, Feng; Flórez-Revuelta, Francisco

    2015-01-01

    Privacy in image and video data has become an important subject since cameras are being installed in an increasing number of public and private spaces. Specifically, in assisted living, intelligent monitoring based on computer vision can allow one to provide risk detection and support services that increase people's autonomy at home. In the present work, a level-based visualisation scheme is proposed to provide visual privacy when human intervention is necessary, such as at telerehabilitation and safety assessment applications. Visualisation levels are dynamically selected based on the previously modelled context. In this way, different levels of protection can be provided, maintaining the necessary intelligibility required for the applications. Furthermore, a case study of a living room, where a top-view camera is installed, is presented. Finally, the performed survey-based evaluation indicates the degree of protection provided by the different visualisation models, as well as the personal privacy preferences and valuations of the users. PMID:26053746

  12. Visual privacy by context: proposal and evaluation of a level-based visualisation scheme.

    PubMed

    Padilla-López, José Ramón; Chaaraoui, Alexandros Andre; Gu, Feng; Flórez-Revuelta, Francisco

    2015-01-01

    Privacy in image and video data has become an important subject since cameras are being installed in an increasing number of public and private spaces. Specifically, in assisted living, intelligent monitoring based on computer vision can allow one to provide risk detection and support services that increase people's autonomy at home. In the present work, a level-based visualisation scheme is proposed to provide visual privacy when human intervention is necessary, such as at telerehabilitation and safety assessment applications. Visualisation levels are dynamically selected based on the previously modelled context. In this way, different levels of protection can be provided, maintaining the necessary intelligibility required for the applications. Furthermore, a case study of a living room, where a top-view camera is installed, is presented. Finally, the performed survey-based evaluation indicates the degree of protection provided by the different visualisation models, as well as the personal privacy preferences and valuations of the users. PMID:26053746

  13. A proposal to evaluate mechanistic efficacy of hallucinogens in addiction treatment.

    PubMed

    Burdick, Brittany Vasae; Adinoff, Bryon

    2013-09-01

    Current treatments for addiction are frequently ineffective. Hallucinogenic therapy has been indicated as helpful for a range of substance use disorders, yet this approach remains understudied and publicly unavailable. It is nonetheless a promising treatment, which has significant, long-term beneficial effects with single doses and a profile characterized by general safety, low toxicity, and non-addictiveness. However, pharmacological interventions, such as hallucinogens, should not be offered if the same effects (e.g. psychological insights/mystical experiences) and outcomes (e.g. decreased drug use) could be achieved absent pharmacological intervention. To date, there have been no clinical comparisons of drug-induced altered states with non-drug-induced states for addiction treatment. We propose and then outline a clinical trial to address this gap in knowledge. The proposed design would evaluate abstinence outcomes in a population of prescription opioid abusers after exposure to one of three conditions: a drug-induced altered state using psilocybin, a non-drug-induced altered state via hyperventilation (Holotropic Breathwork), and an active placebo with niacin. The outcomes of such a study would reveal important differences in therapeutic potential by discriminating hallucinogen-dependent effects from those psychological effects resulting from altered states. PMID:23968172

  14. A proposal to evaluate mechanistic efficacy of hallucinogens in addiction treatment.

    PubMed

    Burdick, Brittany Vasae; Adinoff, Bryon

    2013-09-01

    Current treatments for addiction are frequently ineffective. Hallucinogenic therapy has been indicated as helpful for a range of substance use disorders, yet this approach remains understudied and publicly unavailable. It is nonetheless a promising treatment, which has significant, long-term beneficial effects with single doses and a profile characterized by general safety, low toxicity, and non-addictiveness. However, pharmacological interventions, such as hallucinogens, should not be offered if the same effects (e.g. psychological insights/mystical experiences) and outcomes (e.g. decreased drug use) could be achieved absent pharmacological intervention. To date, there have been no clinical comparisons of drug-induced altered states with non-drug-induced states for addiction treatment. We propose and then outline a clinical trial to address this gap in knowledge. The proposed design would evaluate abstinence outcomes in a population of prescription opioid abusers after exposure to one of three conditions: a drug-induced altered state using psilocybin, a non-drug-induced altered state via hyperventilation (Holotropic Breathwork), and an active placebo with niacin. The outcomes of such a study would reveal important differences in therapeutic potential by discriminating hallucinogen-dependent effects from those psychological effects resulting from altered states.

  15. 78 FR 77122 - Proposed Modification of a General NPDES Permit for Small Suction Dredging-Permit Number IDG-37-0000

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... Procedure Act (APA), or any other law, to publish general notice of proposed rulemaking.'' The RFA exempts... permits are permits, not rulemakings, under the APA and thus not subject to APA rulemaking requirements...

  16. Is there a need for placement evaluations for specialist practice students? A proposal.

    PubMed

    Sturge, Sally Anne

    2014-10-01

    This paper outlines a recent proposal justifying the initiation of standardised placement evaluations across specialist community public health nursing and specialist community nursing students while they undertake their educational programme. Within one approved education institute (AEI) it was identified that there was no standardised tool currently being used across the West Midlands, making the process of quality assurance extremely difficult. A clear rationale is provided for the use of such a tool, including supporting evidence from professional, statutory and regulatory bodies, health and education policies and quality assurance agencies. Placement evaluations are critical to students' learning, ensuring a safe and conducive environment, while providing a continuous cyclical process in conjunction with educational audits to allow the opportunity of regular assessment of the learning environment conforming to the Nursing Midwifery Council's risk-based approach. In light of the recent recommendations from the Francis report, it is pivotal that organisations such as the NHS and AEIs engage proactively together, fostering an open and transparent relationship to ensure standards of care are of the highest quality. Aspects of leadership theory are also discussed to enable the planned change to be successful. PMID:25619067

  17. Pre-participation gynecological evaluation of female athletes: a new proposal

    PubMed Central

    Parmigiano, Tathiana Rebizzi; Zucchi, Eliana Viana Monteiro; de Araujo, Maíta Poli; Guindalini, Camila Santa Cruz; Castro, Rodrigo de Aquino; Bella, Zsuzsanna Ilona Katalin de Jármy Di; Girão, Manoel João Batista Castello; Cohen, Moisés; Sartori, Marair Gracio Ferreira

    2014-01-01

    Objective To propose the inclusion of a gynecological investigation during the evaluation of athletes before competitions, using a specific instrument called the Pre-participation Gynecological Examination (PPGE). Methods The study assessed 148 athletes, mean age of 15.4±2.0 years, who engaged in eight different sports modalities, and who responded to a questionnaire named Pre-Participation Gynecological Examination (PPGE), to the International Consultation on Incontinence Questionnaire - Short Form (for urinary loss), and to the Eating Attitudes Test (for eating disorders). Results Fifty percent of the participants reported irregular menstrual intervals, 23.0% did not know about sexually transmitted diseases, and 72.4% denied having, at least, an annual gynecological appointment. The study identified 18.2% who had urinary loss, and 15% presented with an increased risk of eating disorders. Moreover, 89.9% were not familiar with the occurrence of urinary incontinence in athletes and did not know that they were susceptible to the female athlete triad. A total of 87.1% of them stated that would not mention these issues to their coaches even if this would improve their health or performance. Conclusion The Pre-Participation Gynecological Examination can be considered an easy-to-apply instrument that allowed the diagnosis of alterations often underestimated by the athletes themselves. After its application, the alterations were identified, and determined the athletes’ referral to appropriate evaluation and treatment. PMID:25628197

  18. Proposal of a Nutritional Quality Index (NQI) to Evaluate the Nutritional Supplementation of Sportspeople

    PubMed Central

    Palacin-Arce, Alba; Monteagudo, Celia; Beas-Jimenez, Juan de Dios; Olea-Serrano, Fatima; Mariscal-Arcas, Miguel

    2015-01-01

    Background Numerous supplements are used by sportspeople. They are not always appropriate for the individual or the sports activity and may do more harm than good. Vitamin and mineral supplements are unnecessary if the energy intake is sufficient to maintain body weight and derives from a diet with an adequate variety of foods. The study objectives were to evaluate the main nutrients used as supplements in sports and to propose a nutritional quality index (NQI) that enables sportspeople to optimize their use of supplements and detect and remedy possible nutritional deficits. Material and Methods A nutritional study was performed in 485 sportspeople recruited from Centros Andaluces de Medicina del Deporte, (CAMD). All completed socio-demographic, food frequency, and lifestyle questionnaires. The nutritional quality of their diet and need for supplementation were evaluated by scoring their dietary intake with and without supplementation, yielding two NQI scores (scales of 0-21 points) for each participant. Results A superior mean NQI score was obtained when the supplements taken by participants were not included (16. 28 (SD of 3.52)) than when they were included (15.47 (SD: 3.08)), attributable to an excessive intake of some nutrients through supplementation. Conclusions These results indicate that sportspeople with a varied and balanced diet do not need supplements, which appear to offer no performance benefits and may pose a health risk. PMID:25938239

  19. Is there a need for placement evaluations for specialist practice students? A proposal.

    PubMed

    Sturge, Sally Anne

    2014-10-01

    This paper outlines a recent proposal justifying the initiation of standardised placement evaluations across specialist community public health nursing and specialist community nursing students while they undertake their educational programme. Within one approved education institute (AEI) it was identified that there was no standardised tool currently being used across the West Midlands, making the process of quality assurance extremely difficult. A clear rationale is provided for the use of such a tool, including supporting evidence from professional, statutory and regulatory bodies, health and education policies and quality assurance agencies. Placement evaluations are critical to students' learning, ensuring a safe and conducive environment, while providing a continuous cyclical process in conjunction with educational audits to allow the opportunity of regular assessment of the learning environment conforming to the Nursing Midwifery Council's risk-based approach. In light of the recent recommendations from the Francis report, it is pivotal that organisations such as the NHS and AEIs engage proactively together, fostering an open and transparent relationship to ensure standards of care are of the highest quality. Aspects of leadership theory are also discussed to enable the planned change to be successful.

  20. 40 CFR 35.937-4 - Solicitation and evaluation of proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... practicable, should include persons with technical skills. Oral (including telephone) or written interviews... provided requests for proposals. (b) Requests for professional services proposals must be in writing...

  1. Science intervention programs for Southern Black students: A cluster evaluation and two proposed models

    NASA Astrophysics Data System (ADS)

    Johnson, Courtney Anne

    This study investigated science intervention programs for Black students in South Carolina, Georgia, and Maryland. The sample consisted of five programs that aim to increase the participation of Blacks in science via after-school, Saturday, and summer experiences. These long-term programs offered a variety of experiences, including hands-on science activities, contact with mentors and role models, exposure to science-related careers, and opportunities to increase science content knowledge and improve science process skills. Artifact data, a Program Coordinator Questionnaire, site visits, and interviews were used to identify and describe five existing science intervention programs for Black students. The study proposed a set of standards for science intervention programs for Black students. These standards addressed eight components of programs, including objectives, format, location, target population, recruitment and selection, intervention activities, staff, and financial information. Using a modified approach to cluster evaluation, the five programs were compared to the standards. This evaluation revealed the strengths and underlying weaknesses of the cluster that informed the development of two models for future science intervention programs. Though implemented in numerous ways, the cluster's strengths included sound, measurable objectives; articulation of program objectives to staff, participants, and parents; frequent contact during sessions; the potential for continuous involvement of staff and participants; the inclusion of a range of student achievement levels; programs that served their target group; the representation of various communities, neighborhoods, and schools; effective recruitment strategies; financially inclusive programs; a variety of intervention activities; intensive training for staff, and substantial staff compensation. Three major shortcomings of the cluster were identified as inadequate focus on science-related careers and science

  2. Tier 1 ecological evaluation of proposed discharge of dredged material from Oakland Harbor into ocean waters

    SciTech Connect

    Shreffler, D.K.; Thorn, R.M.; Walls, B.E.; Word, J.Q.

    1994-01-01

    The Water Resources Development Act of 1986 (Public Law 99--662) authorized the U.S. Army Corps of Engineers (USACE) -- San Francisco District, to accommodate larger, deeper draft vessels in Oakland inner and Outer Harbors by deepening and widening the existing navigation channel, and providing turning basins and maneuvering areas in Oakland inner Harbor. The suitability of the resulting dredged material for disposal into ocean waters was subject to the procedures of the 1991 Testing Manual, Evaluation of Dredged Material Proposed for Ocean Disposal, known as the ``Green Book``. The Green Book provides a tiered approach for testing the suitability of dredged materials through chemical, physical, and biological evaluations. The first level of investigation, or Tier 1 evaluation, is used to determine whether a decision on LPC compliance can be made on the basis of readily available information. The Tier 1 report primarily summarizes existing information on sediment contamination and toxicity potential, identifies contaminants of concern, and determines the need for further testing. To assist the USACE in determining the suitability of dredged material from Oakland inner and Outer Harbors for ocean disposal, Battelle/Marine Sciences Laboratory prepared this Tier 1 report based upon information and data provided by USACE. Because this Tier 1 report originated well after an LPC determination was made to require testing of project sediments in Tier 3, the primary purpose of this report was to identify contaminants of concern (if any) in that particular dredged material. In addition, this Tier 1 report summarizes available information on chemical, physical, and biological characterization of the sediments in Oakland inner and Outer Harbors.

  3. Evaluation of materials proposed for the construction of the plasma electrode Pockels cell (PEPC) on beamlet

    SciTech Connect

    Roberts, D.; Robb, C.; DeYoreo, J.; Atherton, J.

    1992-11-01

    The proposed upgrade of the NOVA laser system at Lawrence Livermore National Laboratory employs a multipass architecture that requires an optical switch to emit the laser light at the appropriate fluence. This Pockels cell-based optical switch does not use traditional ring or thin-film electrodes because of the large aperture and high fluence of the laser system. Rather, it uses a plasma electrode Pockels cell with a KD*P crystal as the electro-optical medium. A discharge plasma is formed on each side of the electro-optic crystal and high voltage is applied across the crystal through the plasma electrode to initiate optical switching. In October 1991 we began evaluating materials suggested for the large aperture plasma electrode optical switch. Previous experiments suggested that switching performance could be significantly affected by the deterioration of cell materials. The final prototype switch tested used polyethylene for the switch body, Mykroy for the mid-plane and a silicone vulcanite to encapsulate the KD*P crystal. The encapsulant easily compensated for the effect of assembling the optical switch and we measured no strain-induced birefringence in the crystal after encapsulation. Oxygen was eventually added to the plasma to react with the sputtered carbon from the cathode and produce a gaseous effluent. As an added benefit, the production of ozone absorbed most of the ultra violet radiation affecting the encapsulant. All the materials tested decomposed and produced volatiles, although we have seen no change in the damage threshold of exposed optical surfaces tested to date. The following is an evaluation of the recommended materials for major cell components using published manufacturers data, experimental results from our Material Evaluation Apparatus, and outgassing performance and sputtering data produced at the Laboratory`s Vacuum Process Lab.

  4. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... research and do not jeopardize the unsolicited status of any subsequently submitted proposal. (b) NASA will... proposals. 1260.17 Section 1260.17 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... unsolicited proposals. (a) Unsolicited proposals are for new and innovative ideas. Federal...

  5. Proposed Facility Modifications to Support Propulsion Systems Testing Under Simulated Space Conditions at Plum Brook Station's Spacecraft Propulsion Research Facility (B-2)

    NASA Technical Reports Server (NTRS)

    Edwards, Daryl A.

    2007-01-01

    Preparing NASA's Plum Brook Station's Spacecraft Propulsion Research Facility (B-2) to support NASA's new generation of launch vehicles has raised many challenges for B-2 s support staff. The facility provides a unique capability to test chemical propulsion systems/vehicles while simulating space thermal and vacuum environments. Designed and constructed 4 decades ago to support upper stage cryogenic engine/vehicle system development, the Plum Brook Station B-2 facility will require modifications to support the larger, more powerful, and more advanced engine systems for the next generation of vehicles leaving earth's orbit. Engine design improvements over the years have included large area expansion ratio nozzles, greater combustion chamber pressures, and advanced materials. Consequently, it has become necessary to determine what facility changes are required and how the facility can be adapted to support varying customers and their specific test needs. Instrumental in this task is understanding the present facility capabilities and identifying what reasonable changes can be implemented. A variety of approaches and analytical tools are being employed to gain this understanding. This paper discusses some of the challenges in applying these tools to this project and expected facility configuration to support the varying customer needs.

  6. 45 CFR 690.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... proposals for research to be conducted or supported by a Federal department or agency. 690.120 Section 690.120 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.120 Evaluation and disposition of applications and proposals for...

  7. 34 CFR 97.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 97.120 Section 97.120... the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by...

  8. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a)...

  9. 32 CFR 219.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 219.120 Section 219...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The department...

  10. 40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... applications and proposals for research to be conducted or supported by a Federal Department or Agency. 26.120... SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.120 Evaluation and disposition of applications and proposals for research to be conducted or...

  11. 10 CFR 745.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... applications and proposals for research to be conducted or supported by a Federal department or agency. The... 10 Energy 4 2010-01-01 2010-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal department or agency. 745.120 Section...

  12. 40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.120 Evaluation and disposition of applications and proposals for research to be conducted or supported... applications and proposals for research to be conducted or supported by a Federal Department or Agency....

  13. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section...

  14. The modification and evaluation of an ELISA test for the surveillance of Mycobacterium avium subsp. paratuberculosis infection in wild ruminants

    PubMed Central

    2013-01-01

    developed. In order to generate reliable test results, it is essential to evaluate the test and perform modifications if deemed necessary. Despite the challenges inherent to wildlife diagnostics, we have shown that several methods can be used to improve confidence in test results. PMID:23302439

  15. Objective quality measurement for audio time-scale modification

    NASA Astrophysics Data System (ADS)

    Liu, Fang; Lee, Jae-Joon; Kuo, C. C. J.

    2003-11-01

    The recent ITU-T Recommendation P.862, known as the Perceptual Evaluation of Speech Quality (PESQ) is an objective end-to-end speech quality assessment method for telephone networks and speech codecs through the measurement of received audio quality. To ensure that certain network distortions will not affect the estimated subjective measurement determined by PESQ, the algorithm takes into account packet loss, short-term and long-term time warping resulted from delay variation. However, PESQ does not work well for time-scale audio modification or temporal clipping. We investigated the factors that impact the perceived quality when time-scale modification is involved. An objective measurement of time-scale modification is proposed in this research, where the cross-correlation values obtained from time-scale modification synchronization are used to evaluate the quality of a time-scaled audio sequence. This proposed objective measure has been verified by a subjective test.

  16. Evaluation of a proposed surface colonization equation usingThermothrix thiopara as a model organism.

    PubMed

    Brannan, D K; Caldwell, D E

    1982-06-01

    The colonization equation shown below was evaluated usingThermothrix thiopara as a model organism.[Formula: see text] where: N=number of cells on surface (cells field(-1)); A = attachment rate (cells field(-1) h(-1)); M=specific growth rate (h(-1)); t=incubation period (h).Previous studies of microbial surface colonization consider attachment and growth independently. However, the proposed colonization equation integrates the effects of simultaneous attachment and growth. Using this equation, the specific growth rate ofT. thiopara was found to be 0.38±0.3 h(-1) during in situ colonization. Estimates ofμ were independent of incubation period after 4 h (2 generations). Shorter incubations were inadequate to produce sufficient microcolonies for accurate determination of specific growth rate. Empirical data for the time course of colonization fell within the 95% confidence interval of predicted values. The attachment rate, although assumed to be constant, was found to continuously increase with time. This increase may have been an artifact due to the continuous deposition of travertine on the surface, or may indicate the need for a function to replace A in the colonization equation. Using the exponential growth equation, the progeny of cells that attach during incubation are considered to be progeny of cells that attach initially. This erroneously inflated the growth rate by 55%. PMID:24225694

  17. The Cotingo Dam as a test of Brazil's system for evaluating proposed developments in Amazonia

    NASA Astrophysics Data System (ADS)

    Fearnside, Philip M.; Barbosa, Reinaldo Imbrozio

    1996-09-01

    The proposed Cotingo Dam in Brazil's far northern state of Roraima is examined with the objective of drawing lessons for Brazil's system of evaluating environmental, social, and financial consequences of development decisions. The Cotingo Dam illustrates the difficulty of translating into practice the principles of economic and environmental assessment. Examination of the financial arguments for the Cotingo Dam indicates that justifications in this sphere are insufficient to explain why the project is favored over other alternatives and points to political factors as the best explanation of the project's high priority. Strong pressure from political and entrepreneurial interest groups almost invariably dominates decision making in Amazonia. The analysis indicates the inherent tendency of the present system to produce decisions in favor of large construction projects at the expense of the environment and local peoples. The requirements intended to assure proper weight for these concerns, such as the report on environmental impacts (RIMA) and the public hearing, fail to serve this role. Cotingo also provides a test case for constitutional protections restricting construction of dams in indigenous lands.

  18. Proposal for a screening test to evaluate the fate of organic micropollutants in activated sludge.

    PubMed

    Salvetti, Roberta; Vismara, Renato; Dal Ben, Ilaria; Gorla, Elena; Romele, Laura

    2011-04-01

    The concentrations of organic micropollutants are usually low in wastewaters (order of magnitude of mg L(-1)). However, their emission standards, especially in the case of carcinogenic and bioaccumulating substances, are often much lower (order of magnitude of microg L(-1)). Since these substances, in some cases, can be adsorbable or volatile, their removal via volatilization, biodegradation or sludge adsorption in a wastewater treatment plant (WWTP) becomes a significant feature to include in the usual design process, in order to verify the emission standards in gas and sludge too. In this study a simple screening batch test for the evaluation of the fate of organic micropollutants in water, air and sludge is presented. The test is set up by means of simple laboratory instruments and simulates an activated sludge tank process. In this study the results obtained for four substances with different chemical properties (i.e. toluene, benz(a)anthracene, phenol and benzene) are presented. The screening test proposed can be a useful tool to assess in about one month the fate of organic micropollutants in an activated sludge tank of a WWTP. Moreover, the test can constitute a useful support in the use of mathematical models, since it allows the verification of model results and the calibration of the reactions involved in the removal process. PMID:21877546

  19. Ergonomic evaluation of interior design of Shoka vehicle and proposing recommendations for improvement.

    PubMed

    Mazloumi, Adel; Mohammadreze, Fallah

    2012-01-01

    One of the applications of ergonomics disciplinary is designing driver workstation compatible to users' characteristics. The aim of this study was evaluation of interior design of Shoka vehicle with respect to the accommodation for Iranian population and proposing suggestions for customizing design of this vehicle. This study was a descriptive-analytical study conducted among thirty men from Iranian drivers population in 5, 50, 95 percentiles of the stature variable. Objective variables related to the occupant packaging and vehicle visual aspects including anthropometric variables, frontal, lateral, and side view and so on were investigated first. Then, subjective variables related to the driver mental workload and body comfort discomfort were studied using BMDMW and comfort questionnaires during 2-hour driving trial sessions. Occupant packaging variables and hand-arm angle showed the least accommodation percent (%53). Seating angles showed low accommodation as well (%73). Among three percentile groups there were no significant differences between the mean values of mental workload during two hours driving task. And, the mean value related to the comfort discomfort was 3.9 during driving sessions. Considering the findings in this study, it can be conclude that seating angles need correction and optimization. Taking mental workload results into account, it can be concluded that the interior design of the studied car had no influence on drivers' mental workload. From the aspect of comfort discomfort, Shoka vehicle showed neutral state among drivers. Optimizing seating angles, decreasing vibration, correcting stiffness of seating pan are suggested for customization of the ergonomics aspect of this vehicle.

  20. Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in Humans.

    PubMed

    Momper, Jeremiah D; Tsunoda, Shirley M; Ma, Joseph D

    2016-07-01

    Drug transporters are present in various tissues and have a significant role in drug absorption, distribution, and elimination. The International Transporter Consortium has identified 7 transporters of increasing importance from evidence of clinically significant transporter-mediated drug-drug interactions. The transporters are P-glycoprotein, breast cancer resistance protein, organic anion transporting polypeptide (OATP) 1B1, OATP1B3, organic cation transporter 2, organic anion transporters (OAT) 1, and OAT3. Decision trees were created based on in vitro experiments to determine whether an in vivo transporter-mediated drug-drug interaction study is needed. Phenotyping is a methodology that evaluates real-time in vivo transporter activity, whereby changes in a probe substrate or probe inhibitor reflect alternations in the activity of the specified transporter. In vivo probe substrates and/or probe inhibitors have been proposed for each aforementioned transporter. In vitro findings and animal models provide the strongest evidence regarding probe specificity. However, such findings have not conclusively correlated with human phenotyping studies. Furthermore, the extent of contribution from multiple transporters in probe disposition complicates the ability to discern if study findings are the result of a specific transporter and thus provide a recommendation for a preferred probe for a drug transporter. PMID:27385182

  1. An Evaluation of Proposed Mechanisms of Slab Flattening in Central Mexico

    NASA Astrophysics Data System (ADS)

    Skinner, Steven M.; Clayton, Robert W.

    2011-08-01

    Central Mexico is the site of an enigmatic zone of flat subduction. The general geometry of the subducting slab has been known for some time and is characterized by a horizontal zone bounded on either side by two moderately dipping sections. We systematically evaluate proposed hypotheses for shallow subduction in Mexico based on the spatial and temporal evidence, and we find no simple or obvious explanation for the shallow subduction in Mexico. We are unable to locate an oceanic lithosphere impactor, or the conjugate of an impactor, that is most often called upon to explain shallow subduction zones as in South America, Japan, and Laramide deformation in the US. The only bathymetric feature that is of the right age and in the correct position on the conjugate plate is a set of unnamed seamounts that are too small to have a significant effect on the buoyancy of the slab. The only candidate that we cannot dismiss is a change in the dynamics of subduction through a change in wedge viscosity, possibly caused by water brought in by the slab.

  2. 78 FR 44579 - 30-Day Notice of Proposed Information Collection: Fellowship Placement Pilot Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... URBAN DEVELOPMENT 30-Day Notice of Proposed Information Collection: Fellowship Placement Pilot Program.... A. Overview of Information Collection Title of Information Collection: Fellowship Placement Pilot.... Description of the need for the information and proposed use: The Fellowship Placement Program places...

  3. 34 CFR 413.21 - What selection criteria does the Secretary use to evaluate an application proposing research and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... evaluate an application proposing research and development activities? 413.21 Section 413.21 Education... evaluating each research and development application: (a) Program factors. (20 points) The Secretary reviews each application to determine the extent to which each of the required research and...

  4. STEMs: A Proposal for Calibrated Classroom Assessments That Increase Student Motivation and Provide Authentic Evaluation of Student Learning

    ERIC Educational Resources Information Center

    Murrieta, Hector; Amerson, Gordon

    2011-01-01

    The purpose of this study was to validate the development and proposal of what the authors call STEMs (Standards Tests to Evaluate Mastery) and have defined them as calibrated classroom assessments that increase student motivation and provide authentic evaluation of student learning. Theoretical and empirical research on classroom assessment and…

  5. 78 FR 31999 - 30-Day Notice of Proposed Information Collection: Young Turkey/Young America Evaluation (YTYA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE 30-Day Notice of Proposed Information Collection: Young Turkey/ Young America Evaluation (YTYA) Survey ACTION... Collection: Young Turkey/Young America Evaluation (YTYA) Survey. OMB Control Number: None. Type of...

  6. 78 FR 9448 - 60-Day Notice of Proposed Information Collection: Young Turkey/Young America Evaluation (YTYA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE 60-Day Notice of Proposed Information Collection: Young Turkey/ Young America Evaluation (YTYA) Survey ACTION... Information Collection: Young Turkey/Young America Evaluation (YTYA) Survey. OMB Control Number: None. Type...

  7. 48 CFR 215.203-70 - Requests for proposals-tiered evaluation of offers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 215.203-70 Requests for...

  8. 7 CFR 1487.6 - What are the criteria for evaluating proposals?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... barrier; (2) The potential trade impact of the proposed project on market retention, market access, and market expansion, including the potential for expanding commercial sales in the targeted market; (3) The... proposal is targeted to a market in which the United States is generally competitive; (6) The cost of...

  9. 77 FR 30050 - VASRD Status Summit: A Public Overview of Proposed Disability Evaluation Criteria

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... following nine body systems: (1) The Hemic and Lymphatic Systems (38 CFR 4.117), (2) The Endocrine System... Summit is to capture public comments on working drafts of proposed regulations for nine body ] systems... their input, prior to the drafting of proposed regulations for the body systems. VA plans to...

  10. 75 FR 34146 - Proposed Collection; Comment Request Resource for the Collection and Evaluation of Human Tissues...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... Collection and Evaluation of Human Tissues and Cells From Donors With an Epidemiology Profile (NCI) SUMMARY... Collection: Title: Resource for the Collection and Evaluation of Human Tissues and Cells From Donors With...

  11. Home Modification

    MedlinePlus

    ... it is important to consider certain safety modifications. Adaptations such as those in the following list can ... The importance of a Consumer Perspective in Home Adaptation of Alzheimer’s Households” (Chapter 6 pp 91-112) ...

  12. Parameter Selection and Model Uncertainty in the Evaluation of Contaminant Transport From a Proposed Sulfide Mine Tailings Perpetual Storage Facility, a Case Study.

    NASA Astrophysics Data System (ADS)

    Thibodeau, P. M.

    2004-05-01

    An independent contaminant transport model (hereafter, ITM) was created, using MT3D96 (Zheng, 1996), to evaluate the movement and concentration distribution of constituents of concern that would likely leach out of a proposed Tailings Management Area (TMA) for the formerly proposed Crandon Mine in Forest County, Wisconsin. The Crandon Mine proposal included mining of zinc and copper ore from an identified high sulfide mineral deposit, with on-site processing and perpetual storage of mine tailings. The contaminant transport model was developed using an independently-derived groundwater flow model (hereafter, IFM), created by the investigators and others, as part of a comprehensive analysis of site hydrogeology and solute transport dynamics. Data and discretization of solute transport parameters, simulation specifications, and TMA activity phases, were performed using existing information provided in the Crandon Mine proponent's submissions. The only initial modification to the proponent's transport model (hereafter, PTM) was the substitution of a revised conceptual model of the hydrogeology as depicted in the IFM. The new ITM provided a baseline for comparison to the proponent's evaluation of potential acid mine drainage (AMD) from the TMA and into the surrounding groundwater. Receiving surface waters and wetlands are located approximately 1,500 feet from the proposed TMA. Activities at the proposed TMA were evaluated through a series of six discrete MT3D model simulations, representing the various proposed operations and leakage phases for the facility and associated reclaim pond. Contaminant transport model results were superpositioned to provide a cumulative contaminant concentration response over time and evaluated at a distance of 1,200 feet from the proposed TMA. A simplifying assumption was that AMD constituents flowed conservatively through the groundwater system, with neither adsorption, decay, nor reactivity over time and travel. The maximum concentration

  13. 75 FR 26283 - Proposed Collection, Submission for OMB Review, Museums for America Grant Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... Program Evaluation AGENCY: Institute of Museum and Library Services, The National Foundation on the Arts... for America Grant Program Evaluation. The 60-day Notice for ``Museums for America Grant Program Evaluation'' was published in the Federal Register on November 24, 2009 (FR vol. 74, no. 225, pg...

  14. Ubiquitin modifications

    PubMed Central

    Swatek, Kirby N; Komander, David

    2016-01-01

    Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid protein ubiquitin is subjected to further modifications, creating a multitude of distinct signals with distinct cellular outcomes, referred to as the 'ubiquitin code'. Ubiquitin can be ubiquitinated on seven lysine (Lys) residues or on the N-terminus, leading to polyubiquitin chains that can encompass complex topologies. Alternatively or in addition, ubiquitin Lys residues can be modified by ubiquitin-like molecules (such as SUMO or NEDD8). Finally, ubiquitin can also be acetylated on Lys, or phosphorylated on Ser, Thr or Tyr residues, and each modification has the potential to dramatically alter the signaling outcome. While the number of distinctly modified ubiquitin species in cells is mind-boggling, much progress has been made to characterize the roles of distinct ubiquitin modifications, and many enzymes and receptors have been identified that create, recognize or remove these ubiquitin modifications. We here provide an overview of the various ubiquitin modifications present in cells, and highlight recent progress on ubiquitin chain biology. We then discuss the recent findings in the field of ubiquitin acetylation and phosphorylation, with a focus on Ser65-phosphorylation and its role in mitophagy and Parkin activation. PMID:27012465

  15. Liposomal doxorubicin for active targeting: surface modification of the nanocarrier evaluated in vitro and in vivo — challenges and prospects

    PubMed Central

    Mentz, Susanne

    2015-01-01

    Due to the inability of classical chemotherapeutic agents to exclusively target tumor cells, these treatments are associated with severe toxicity profiles. Thus, long-circulating liposomes have been developed in the past to enhance accumulation in tumor tissue by passive targeting. Accordingly, commercially available liposomal formulations of sterically stabilized liposomal doxorubicin (Caelyx®, Doxil®, Lipodox®) are associated with improved off-target profiles. However, these preparations are still not capable to selectively bind to target cells. Thus, in an attempt to further optimize existing treatment schemes immunoliposomes have been established to enable active targeting of tumor tissues. Recently, we have provided evidence for therapeutic efficacy of anti-IGF1R-targeted, surface modified doxorubicin loaded liposomes. Our approach involved a technique, which allows specific post-modifications of the liposomal surface by primed antibody-anchor conjugates thereby facilitating personalized approaches of commercially available liposomal drugs. In the current study, post-modification of sterically stabilized liposomal Dox was thoroughly investigated including the influence of different modification techniques (PIT, SPIT, SPIT60), lipid composition (SPC/Chol, HSPC/Chol), and buffers (HBS, SH). As earlier in vivo experiments did not take into account the presence of non-integrated ab-anchor conjugates this was included in the present study. Our experiments provide evidence that post-modification of commercially available liposomal preparations for active targeting is possible. Moreover, lyophilisation represents an applicable method to obtain a storable precursor of surface modifying antibody-anchor conjugates. Thus, these findings open up new approaches in patient individualized targeting of chemotherapeutic therapies. PMID:26497207

  16. Experimental evaluation of two turning vane designs for high-speed corner of 0.1-scale model of NASA Lewis Research Center's proposed altitude wind tunnel

    NASA Technical Reports Server (NTRS)

    Moore, R. D.; Boldman, D. R.; Shyne, R. J.

    1986-01-01

    Two turning vane designs were experimentally evaluated for corner 1 (downstream of the test section) of a 0.1-scale model of the NASA Lewis Research Center's proposed Altitude Wind Tunnel (AWT). Vane A was a controlled-diffusion airfoil shape; vane B was a circular-arc airfoil shape. The vane designs were tested over corner inlet Mach numbers from 0.16 to 0.465. Several modifications in vane setting angle and vane spacing were also evaluated for vane A. The overall performance obtained from total pressure rakes indicated that vane B had a slightly lower loss coefficient than vane A. At Mach 0.35 (the design Mach number without the engine exhaust removal scoop), the loss coefficients were 0.150 and 0.178 for vanes B and A, respectively. Resetting the vane A angle by -5 deg. (vane A10) to turn the flow toward the outside corner reduced the loss coefficient to 0.119. The best configuration (vane A10) was also tested with a simulated engine exhaust removal scoop. The loss coefficient for that configuration was 0.164 at Mach 0.41 (the approximate design Mach number with the scoop).

  17. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... selection factors on the basis of a narrative explanation, discussing any subfactors when applicable. For... proposal that the Director determines on the basis of a narrative explanation will, on an overall...

  18. 76 FR 15281 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... study will assess the quality and quantity of nutrition information available to school food authorities... Food and Nutrition Service Agency Information Collection Activities: Proposed Collection; Comment... Authorities About Food Service Products and Commodities AGENCY: Food and Nutrition Service (FNS), USDA....

  19. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... selection factors on the basis of a narrative explanation, discussing any subfactors when applicable. For... proposal that the Director determines on the basis of a narrative explanation will, on an overall...

  20. Evaluation and modification of five techniques for estimating stormwater runoff for watersheds in west-central Florida

    USGS Publications Warehouse

    Trommer, J.T.; Loper, J.E.; Hammett, K.M.

    1996-01-01

    Several traditional techniques have been used for estimating stormwater runoff from ungaged watersheds. Applying these techniques to water- sheds in west-central Florida requires that some of the empirical relationships be extrapolated beyond tested ranges. As a result, there is uncertainty as to the accuracy of these estimates. Sixty-six storms occurring in 15 west-central Florida watersheds were initially modeled using the Rational Method, the U.S. Geological Survey Regional Regression Equations, the Natural Resources Conservation Service TR-20 model, the U.S. Army Corps of Engineers Hydrologic Engineering Center-1 model, and the Environmental Protection Agency Storm Water Management Model. The techniques were applied according to the guidelines specified in the user manuals or standard engineering textbooks as though no field data were available and the selection of input parameters was not influenced by observed data. Computed estimates were compared with observed runoff to evaluate the accuracy of the techniques. One watershed was eliminated from further evaluation when it was determined that the area contributing runoff to the stream varies with the amount and intensity of rainfall. Therefore, further evaluation and modification of the input parameters were made for only 62 storms in 14 watersheds. Runoff ranged from 1.4 to 99.3 percent percent of rainfall. The average runoff for all watersheds included in this study was about 36 percent of rainfall. The average runoff for the urban, natural, and mixed land-use watersheds was about 41, 27, and 29 percent, respectively. Initial estimates of peak discharge using the rational method produced average watershed errors that ranged from an underestimation of 50.4 percent to an overestimation of 767 percent. The coefficient of runoff ranged from 0.20 to 0.60. Calibration of the technique produced average errors that ranged from an underestimation of 3.3 percent to an overestimation of 1.5 percent. The average

  1. 76 FR 47154 - Proposed Information Collection; Comment Request; California Signage Plan: Evaluation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ...; California Signage Plan: Evaluation of Interpretive Signs AGENCY: National Oceanic and Atmospheric... for a regular submission (new collection). The California Signage Plan is an organized and...

  2. 78 FR 10593 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... 103, directs USDA to demonstrate direct certification for free lunches and breakfasts to children who... Request--Evaluation of the Demonstrations of National School Lunch and School Breakfast Program (NSLP/SBP.... This is a new collection for Evaluation of the Demonstrations of NSLP/SBP (National School...

  3. A Proposal to Build Evaluation Capacity at the Bunche-Da Vinci Learning Partnership Academy

    ERIC Educational Resources Information Center

    King, Jean A.

    2005-01-01

    The author describes potential evaluation capacity-building activities in contrast to the specifics of an evaluation design. Her response to the case of the Bunche-Da Vinci Learning Partnership Academy is developed in three parts: (1) an initial framing of the Bunche-Da Vinci situation; (2) what should be done before signing a contract; and (3)…

  4. The Under-Examined Life: A Proposal for Critically Evaluating Teachers' and Students' Philosophies of Teaching

    ERIC Educational Resources Information Center

    Reber, Jeffrey

    2011-01-01

    Teachers are encouraged to critically evaluate their philosophy of teaching and to help students recognize and examine their implicit ideas about education as well. This critical evaluation entails examining assumptions about teaching and learning, investigating the implications that follow from those assumptions, and considering alternative ideas…

  5. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Early termination of research support: Evaluation... SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.123 Early termination of research support: Evaluation of applications and...

  6. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... rights and welfare of human subjects (whether or not the research was subject to federal regulation). ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Early termination of research support: Evaluation... Research Subjects § 46.123 Early termination of research support: Evaluation of applications and...

  7. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Early termination of research support: Evaluation of... Protection of Human Research Subjects) § 97.123 Early termination of research support: Evaluation of... persons who would direct or has have directed the scientific and technical aspects of an activity has...

  8. 7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Early termination of research support: Evaluation of... OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications and... direct or has have directed the scientific and technical aspects of an activity has have, in the...

  9. 49 CFR 11.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Early termination of research support: Evaluation... Transportation PROTECTION OF HUMAN SUBJECTS § 11.123 Early termination of research support: Evaluation of... persons who would direct or has/have directed the scientific and technical aspects of an activity...

  10. 76 FR 9607 - Notice of Proposed Information Collection for Technical Evaluation Surveys

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... this collection of information was published on November 5, 2010 (75 FR 68376). No comments were... Technical Evaluation Surveys AGENCY: Office of Surface Mining Reclamation and Enforcement, Interior. ACTION... request for its Technical Evaluation customer surveys has been forwarded to the Office of Management...

  11. 77 FR 30045 - 30-Day Notice of Proposed Information Collection: English Language Evaluation Surveys

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Information Collection: English Language Evaluation Surveys ACTION: Notice of request for public comment and... English Language Evaluation, to conduct surveys of participants in the ETA Program, E-Teacher Scholarship program, and the English Language Specialist Program. Participants are those who went on the...

  12. 23 CFR 636.302 - Are there any limitations on the selection and use of proposal evaluation factors?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal Evaluation Factors § 636.302... release the final RFP and award the design-build contract before the conclusion of the NEPA process (see... make any payments to the design-builder for any work performed prior to the completion of the...

  13. 34 CFR 413.22 - What selection criteria does the Secretary use to evaluate an application proposing dissemination...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What selection criteria does the Secretary use to evaluate an application proposing dissemination and training activities? 413.22 Section 413.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT...

  14. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  15. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  16. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  17. PROPOSED STANDARD TO GREATLY EXPAND PUBLIC ACCESS AND EXPLORATION OF TOXICITY DATA: EVALUATION OF STRUCTURE DATA FILE FORMAT

    EPA Science Inventory



    PROPOSED ST ANDARD TO GREA TL Y EXP AND PUBLIC ACCESS AND EXPLORATION OF TOXICITY DATA: EVALUATION OF STRUCTURE DATA FILE FORMAT

    The ability to assess the potential toxicity of environmental, pharmaceutical, or industrial chemicals based on chemical structure in...

  18. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  19. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  20. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  1. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  2. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  3. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  4. Hydrologic evaluation of proposed ground-water withdrawals in Muleshoe Flat near Wheatland, southeastern Wyoming

    USGS Publications Warehouse

    Hoxie, D.T.

    1983-01-01

    The hydrologic effects of proposed irrigation with groundwater of 8,320 acres of land in Muleshoe Flat, a 34 sq mi area in west-central Platte County, Wyoming, were assessed. Results generated by a digital groundwater flow model indicate that, at the end of a 40-yr period, groundwater level declines of more than 50 ft can be expected in an area of 12.5 sq mi and of more than 200 ft in an area of 7 sq mi. In addition, streamflow depletions of 4,300 acre-ft/yr can be expected in the Laramie River and 4,700 acre-ft/yr in Sybille Creek. Additional hydrologic field data collection prior to initiation of the proposed irrigation development would improve these assessments. Applications for the proposed irrigation wells were denied subsequent to the data collection and analysis described in this report. (Author 's abstract)

  5. [Lifestyle modifications].

    PubMed

    Kawano, Yuhei

    2015-11-01

    Lifestyle modifications are important in the prevention and treatment of hypertension. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH2014) recommend salt reduction (< 6 g/day), increased intake of vegetables/fruit and fish (fish oil), reduced intake of cholesterol and saturated fatty acids, weight loss (body mass index < 25kg/m2), exercise (≥ 30 min/day), reduction of alcohol intake (≤ 20-30 mL/day in men, ≤ 10-20 mL/day in women as ethanol), and quitting smoking. These lifestyle modifications are capable of reducing blood pressure and ameliorating other cardiovascular risk factors. However, the reduction in blood pressure is mild to moderate and the adherence to lifestyle modifications has been still suboptimal. PMID:26619658

  6. DNA modifications: Another stable base in DNA

    NASA Astrophysics Data System (ADS)

    Brazauskas, Pijus; Kriaucionis, Skirmantas

    2014-12-01

    Oxidation of 5-methylcytosine has been proposed to mediate active and passive DNA demethylation. Tracking the history of DNA modifications has now provided the first solid evidence that 5-hydroxymethylcytosine is a stable epigenetic modification.

  7. H Scan/AHP decision process planning for evaluating and ranking of proposals submitted to the DOE hydrogen program

    SciTech Connect

    Szoka de Valladares, M.R.; Mack, S.

    1995-09-01

    The DOE Hydrogen Program needs to develop criteria as part of a systematic evaluation process for proposal identification, evaluation and selection. The H Scan component of this process provides a framework in which a project proposer can fully describe their candidate technology system and its components. The H Scan complements traditional methods of capturing cost and technical information. It consists of a special set of survey forms designed to elicit information so expert reviewers can assess the proposal relative to DOE specified selection criteria. The Analytic Hierarchy Process (AHP) component of the decision process assembles the management defined evaluation and selection criteria into a coherent multi-level decision construct by which projects can be evaluated in pair-wise comparisons. The AHP model will reflect management`s objectives and it will assist in the ranking of individual projects based on the extent to which each contributes to management`s objectives. This paper contains a detailed description of the products and activities associated with the planning and evaluation process: The objectives or criteria; the H Scan; and The Analytic Hierarchy Process (AHP).

  8. 75 FR 62543 - Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... Translational Science Awards (CTSA) Initiative SUMMARY: In compliance with the requirement of Section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995, for opportunity for public comment on proposed data... Clinical and ] Translational Science Awards (CTSA) Initiative. Type of Information Collection Request:...

  9. 14 CFR § 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  10. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  11. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  12. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  13. [Hygienic evaluation of proposed materials for an oxygen-converter plant].

    PubMed

    Malevanyĭ, V N

    1990-01-01

    The proposed article presents results of a hygienic assessment of a converter shop project at a metallurgic plant. Labour conditions in similar metallurgic plants in the country were studied at the preliminary sanitary control stage. 81 per cent of the sanitary authorities' reclamations were met, including dust discharge control measures, out-flowing gases purification, decrease of fluorine compounds discharge measures, etc. PMID:2139427

  14. 78 FR 68810 - Agency Information Collection Activities: Proposed Collection; Comment Request-2014 Evaluation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ... free or reduced- price school meals impacted the prevalence of very low food security among children as... Food and Nutrition Service Agency Information Collection Activities: Proposed Collection; Comment... Food Insecurity AGENCY: Food and Nutrition Service (FNS), USDA. ACTION: Notice. SUMMARY: In...

  15. 77 FR 35665 - Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... number of students who are achieving proficiency ] on state assessments of math and reading. The CSP... part of its annual review of Mathematics and Science Partnership final-year evaluations. The...

  16. 76 FR 70470 - Notice of Submission of Proposed Information Collection to OMB Evaluation of the Veterans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... Veterans Homelessness Prevention Demonstration AGENCY: Office of Policy Development and Research, HUD... Veterans Homelessness Prevention Demonstration (VHPD). The Department solicits public comments on the... approval to collect information to evaluate the Veterans Homelessness Prevention Demonstration. The FY...

  17. 77 FR 60746 - Proposed Information Collection (VA/DOD Joint Disability Evaluation Board Claim) Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ... Interagency Task Force on Returning Global War on Terror Heroes, VA and the Department of Defense (DOD) have agreed to develop a joint process in which Global War on Terror (GWOT) service members are evaluated...

  18. Mock Proposals and Other Group Assignments: Bridging Didactic Research Evaluation Skills to Research Applications.

    ERIC Educational Resources Information Center

    Sauer, Karen Ann; Draugalis, JoLaine Reierson

    2000-01-01

    This discusses an educational strategy designed to create a means for students to connect skills introduced in a course sequence during their second professional year with an evaluative Doctor of Pharmacy project conducted later in the curriculum. (Author)

  19. Proposed amendment for Presidential Permit PP-63 and associated modifications to 500 kV international transmission line, Forbes, Minnesota to Manitoba, Canada Northern States Power Company. Final Environmental Assessment

    SciTech Connect

    Not Available

    1992-02-01

    Northern States Power Company, (NSP), a Minnesota investor owned utility has applied to the Office of Fossil Energy, United States Department of Energy, to amend Presidential Permit PP-63 to allow for alterations to the 500 kV transmission line and as sedated facilities currently regulated by this permit. The alterations proposed for the 500 kV line owned by NSP are part of a long term effort sponsored by NSP to upgrade the existing NSP transmission system to allow for increased exchange of electricity with the Manitoba Hydro-Electric Board. Presidential Permit PP-63 authorized NSP to construct, connect, operate and maintain a 500 kV line at the United States/Canadian border approximately seven-and-a-half miles west of Warroad in Roseau County, Minnesota. This line connects with a 500 kV line owned and operated by the Manitoba Hydro-Electric Board (MHEB), which extends from Dorsey, Manitoba, Canada to the United States/Canadian border. NSP proposes to increase the electricity transfer capability of this transmission facility by constructing a new 80-acre substation on the existing 500 kV line in Roseau County, Minnesota, and upgrading the existing substation at Forbes, Minnesota. The proposed Roseau substation would contain two 41.5 ohm series capacitor banks. In addition, static VAR compensators are to be installed at the existing Forbes Substation. Approximately 5 acres would be added to the 30-acre Forbes site to house the additional equipment. No new lines would enter or exit the facility. NSP proposes to place the new Roseau Substation in service in May 1993 and to complete the upgrading of the Forbes Substation in March 1994. The primary, initial purpose of these modifications is to enable NSP to import 400 megawatts of electric power from MHEB during the summer months to meet peak electrical demand in the Minneapolis-St. Paul area. It is expected that this power transfer would begin in 1993.

  20. Evaluation, modification and validation of a set of asthma illustrations in children with chronic asthma in the emergency department

    PubMed Central

    Tulloch, Joanie; Vaillancourt, Régis; Irwin, Danica; Pascuet, Elena

    2012-01-01

    OBJECTIVES: To test, modify and validate a set of illustrations depicting different levels of asthma control and common asthma triggers in pediatric patients (and/or their parents) with chronic asthma who presented to the emergency department at the Children’s Hospital of Eastern Ontario, Ottawa, Ontario. METHODS: Semistructured interviews using guessability and translucency questionnaires tested the comprehensibility of 15 illustrations depicting different levels of asthma control and common asthma triggers in children 10 to 17 years of age, and parents of children one to nine years of age who presented to the emergency department. Illustrations with an overall guessability score <80% and/or translucency median score <6, were reviewed by the study team and modified by the study’s graphic designer. Modifications were made based on key concepts identified by study participants. RESULTS: A total of 80 patients were interviewed. Seven of the original 15 illustrations (47%) required modifications to obtain the prespecified guessability and translucency goals. CONCLUSION: The authors successfully developed, modified and validated a set of 15 illustrations representing different levels of asthma control and common asthma triggers. PRACTICE IMPLICATIONS: These illustrations will be incorporated into a child-friendly asthma action plan that enables the child to be involved in his or her asthma self-management care. PMID:22332128

  1. Evaluation of six NEHRP B/C crustal amplification models proposed for use in western North America

    USGS Publications Warehouse

    Boore, David; Campbell, Kenneth W.

    2016-01-01

    We evaluate six crustal amplification models based on National Earthquake Hazards Reduction Program (NEHRP) B/C crustal profiles proposed for use in western North America (WNA) and often used in other active crustal regions where crustal properties are unknown. One of the models is based on an interpolation of generic rock velocity profiles previously proposed for WNA and central and eastern North America (CENA), in conjunction with material densities based on an updated velocity–density relationship. A second model is based on the velocity profile used to develop amplification factors for the Next Generation Attenuation (NGA)‐West2 project. A third model is based on a near‐surface velocity profile developed from the NGA‐West2 site database. A fourth model is based on velocity and density profiles originally proposed for use in CENA but recently used to represent crustal properties in California. We propose two alternatives to this latter model that more closely represent WNA crustal properties. We adopt a value of site attenuation (κ0) for each model that is either recommended by the author of the model or proposed by us. Stochastic simulation is used to evaluate the Fourier amplification factors and their impact on response spectra associated with each model. Based on this evaluation, we conclude that among the available models evaluated in this study the NEHRP B/C amplification model of Boore (2016) best represents median crustal amplification in WNA, although the amplification models based on the crustal profiles of Kamai et al. (2013, 2016, unpublished manuscript, see Data and Resources) and Yenier and Atkinson (2015), the latter adjusted to WNA crustal properties, can be used to represent epistemic uncertainty.

  2. Re-Framing Teacher Evaluation Discourse in the Media: An Analysis and Narrative-Based Proposal

    ERIC Educational Resources Information Center

    Ulmer, Jasmine B.

    2016-01-01

    Recent publications by major newspapers in the USA have reinforced the perception that teacher quality represents a national crisis. By releasing individual teacher evaluation data in online, searchable databases, several newspapers have influenced public perceptions of teachers and teaching. A framing analysis of selected media events and…

  3. Evaluation of Training in Organisations: A Proposal for an Integrated Model

    ERIC Educational Resources Information Center

    Pineda, Pilar

    2010-01-01

    Purpose: Training is a key strategy for human resources development and in achieving organisational objectives. Organisations and public authorities invest large amounts of resources in training, but rarely have the data to show the results of that investment. Only a few organisations evaluate training in depth due to the difficulty involved and…

  4. Testing and Evaluation of the EOSDIS Core System: An ECS Science Advisor Proposal

    NASA Technical Reports Server (NTRS)

    Welch, Ronald M.; Christopher, Sundar A.

    1997-01-01

    The major goal of this project was to: 1) perform hands on testing of the evaluation packages, 2) provide feedback in the design of the EOSDIS Core System, and 3) test the effectiveness of the DAAC's by acquiring and testing remote sensing data sets.

  5. 76 FR 24060 - Proposed Extension of Existing Information Collection; Testing, Evaluation, and Approval of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... Web site: select ``Rules & Regs'' on the right side of the screen; then select ``FR Docs''; and under..., Evaluation, and Approval of Mining Products AGENCY: Mine Safety and Health Administration. ACTION: Notice of... inspection, testing, approval and certification, and quality control of mining equipment and...

  6. 77 FR 62518 - Proposed Collection; Comment Request: Recipient Epidemiology and Donor Evaluation Study-III (REDS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ...: Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Type of Information Collection Request: New. Need and Use of Information Collection: The objective of the Recipient Epidemiology and Donor... medical procedures. REDS-II conducted studies of blood donor health but much more needs to be...

  7. 76 FR 70748 - Proposed Information Collection; Policy for Evaluation of Conservation Efforts When Making...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... endangered species under the ESA. The Policy for Evaluation of Conservation Efforts When Making Listing Decisions (PECE) (68 FR 15100) encourages the development of conservation agreements/plans and provides... Efforts When Making Listing Decisions (PECE) AGENCY: Fish and Wildlife Service, Interior. ACTION:...

  8. A Proposed Model for the Analysis and Interpretation of Focus Groups in Evaluation Research

    ERIC Educational Resources Information Center

    Massey, Oliver T.

    2011-01-01

    Focus groups have an established history in applied research and evaluation. The fundamental methods of the focus group technique have been well discussed, as have their potential advantages. Less guidance tends to be provided regarding the analysis of data resulting from focus groups or how to organize and defend conclusions drawn from the…

  9. 77 FR 39490 - Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...; Evaluation of the Carol M. White Physical Education Program SUMMARY: The Carol M. White Physical Education... regarding burden and/or the collection activity requirements should be electronically mailed to ICDocketMgr..., including through the use of information technology. Please note that written comments received in...

  10. 75 FR 20977 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... Request--Evaluation of Reaching the Underserved Elderly and Working Poor in SNAP AGENCY: Food and... Elderly and Working Poor in SNAP. DATES: Written comments must be received on or before June 21, 2010... Underserved Elderly and Working Poor in SNAP: FY 2009 Pilots. Form Number: OMB Number: Expiration Date:...

  11. Technical Evaluations of Proposed Remote-Handled Transuranic Waste Characterization Requirements at WIPP

    SciTech Connect

    Anastas, G.; Channell, J. K.

    2002-02-26

    Characterization, packaging, transport, handling and disposal of remotely handled transuranic (RH TRU) waste at WIPP will be different than similar operations with contact handled transuranic (CH TRU) waste. This paper presents results of technical evaluations associated with the planned disposal of remotely handled transuranic waste at the Waste Isolation Pilot Plant (WIPP).

  12. 76 FR 72003 - Proposed Collection, Laura Bush 21st Century Librarian Grant Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ...., Evaluation and Research Officer, Institute of Museum and Library Services, 1800 M St., NW., Washington, DC... funds made available by the Institute. Current research initiatives include analysis of grants made to educational and training programs by the Laura Bush 21st Century Librarian Grant Program between 2003 and...

  13. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... restrictive notice prescribed in paragraph (e) of the provision at 48 CFR 52.215-1 to such information. In any... information (data) in question as an exemption under the Act. (See also 48 CFR 24.2, Freedom of Information... information during evaluation. 915.207-70 Section 915.207-70 Federal Acquisition Regulations System...

  14. 77 FR 36292 - Proposed Collection, Comments Requested: FBI National Academy Level III Evaluation; FBI National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE... Evaluation; FBI National Academy Post-Course Questionnaire for Graduates, FBI National Academy Post-Course... National Academy Post-Course Questionnaire for Graduates. FBI National Academy Post-Course...

  15. 40 CFR 26.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Early termination of research support... PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.123 Early termination of research support: Evaluation...

  16. 40 CFR 26.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Early termination of research support... Research Conducted or Supported by EPA § 26.123 Early termination of research support: Evaluation of... persons who would direct or has have directed the scientific and technical aspects of an activity has...

  17. 28 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Early termination of research support... (CONTINUED) PROTECTION OF HUMAN SUBJECTS § 46.123 Early termination of research support: Evaluation of... persons who would direct or has have directed the scientific and technical aspects of an activity has...

  18. 77 FR 62494 - Proposed Information Collection; Comment Request; Evaluations of Coastal Zone Management Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ...; Evaluations of Coastal Zone Management Act Programs--State Coastal Management Programs and National Estuarine... . SUPPLEMENTARY INFORMATION: I. Abstract This request is for a new information collection. The Coastal Zone Management Act of 1972, as amended (CZMA; 16 U.S.C. 1451 et seq.) requires that state coastal...

  19. 76 FR 54507 - Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... the effects of natural phenomena, including earthquakes, without losing the capability to perform... 10 CFR part 50, General Design Criteria (GDC) 2. The state of knowledge of seismic hazard within the... need to evaluate in more detail the impact of updated seismic hazard information with respect...

  20. Rigor, Impact and Prestige: A Proposed Framework for Evaluating Scholarly Publications

    ERIC Educational Resources Information Center

    West, Richard E.; Rich, Peter J.

    2012-01-01

    As publication pressure has increased in the world of higher education, more journals, books, and other publication outlets have emerged. Thus it is critical to develop clear criteria for effectively evaluating the quality of publication outlets. Without such criteria funding agencies and promotion committees are forced to guess at how to evaluate…

  1. 78 FR 48879 - Proposed Collection; 60-day Comment Request: Outcomes Evaluation of the National Cancer Institute...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ... Evaluation of the National Cancer Institute (NCI) Cancer Prevention Fellowship Program (CPFP) SUMMARY: In..., Cancer Prevention Fellowship Program, National Cancer Institute, 9609 Medical Center Drive, Room 2W136... Fellowship Program (CPFP), 0925-NEW, National Cancer Institute (NCI), National Institutes of Health...

  2. Modification and Biological Evaluation of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion

    PubMed Central

    2015-01-01

    Fascin has recently emerged as a potential therapeutic target, as its expression in cancer cells is closely associated with tumor progression and metastasis. Following the initial discovery of a series of thiazole derivatives that demonstrated potent antimigration and antiinvasion activities via possible inhibition of fascin function, we report here the design and synthesis of 63 new thiazole derivatives by further structural modifications in search of more potent fascin inhibitors. The 5 series of analogues with longer alkyl chain substitutions on the thiazole nitrogen exhibited greater antimigration activities than those with other structural motifs. The most potent analogue, 5p, inhibited 50% of cell migration at 24 nM. Moreover, the thiazole analogues showed strong antiangiogenesis activity, blocking new blood vessel formation in a chicken embryo membrane assay. Finally, a functional study was conducted to investigate the mechanism of action via interaction with the F-actin bundling protein fascin. PMID:25007006

  3. Evaluation of proposed German safety criteria for high-temperature gas-cooled reactors

    SciTech Connect

    Barsell, A.W.

    1980-05-01

    This work reviews proposed safety criteria prepared by the German Bundesministerium des Innern (BMI) for future licensing of gas-cooled high-temperature reactor (HTR) concepts in the Federal Republic of Germany. Comparison is made with US General Design Criteria (GDCs) in 10CFR50 Appendix A and with German light water reactor (LWR) criteria. Implications for the HTR design relative to the US design and safety approach are indicated. Both inherent characteristics and design features of the steam cycle, gas turbine, and process heat concepts are taken into account as well as generic design options such as a pebble bed or prismatic core.

  4. New partial skeletons of Palaeocene Nyctitheriidae and evaluation of proposed euarchontan affinities

    PubMed Central

    Manz, Carly L.; Chester, Stephen G. B.; Bloch, Jonathan I.; Silcox, Mary T.; Sargis, Eric J.

    2015-01-01

    Small-bodied, insectivorous Nyctitheriidae are known in the Palaeogene fossil record almost exclusively from teeth and fragmentary jaws and have been referred to Eulipotyphla (shrews, moles and hedgehogs) based on dental similarities. By contrast, isolated postcrania attributed to the group suggest arboreality and a relationship to Euarchonta (primates, treeshrews and colugos). Cretaceous–Palaeocene adapisoriculid insectivores have also been proposed as early euarchontans based on postcranial similarities. We describe the first known dentally associated nyctitheriid auditory regions and postcrania, and use them to test the proposed relationship to Euarchonta with cladistic analyses of 415 dental, cranial and postcranial characteristics scored for 92 fossil and extant mammalian taxa. Although nyctitheriid postcrania share similarities with euarchontans likely related to arboreality, results of cladistic analyses suggest that nyctitheriids are closely related to Eulipotyphla. Adapisoriculidae is found to be outside of crown Placentalia. These results suggest that similarities in postcranial morphology among nyctitheriids, adapisoriculids and euarchontans represent separate instances of convergence or primitive retention of climbing capabilities. PMID:25589486

  5. A proposed wind measurement and analysis approach for evaluating a prospective wind plant site

    NASA Astrophysics Data System (ADS)

    Wendell, L. L.; Barnard, J. C.; Morris, V. R.

    1994-05-01

    On the basis of research results, cooperative efforts with wind energy developers, and work with meteorological consultants, Pacific Northwest Laboratory (PNL) has proposed an approach for performing wind measurement assessments for prospective wind plant sites. The primary goal of this approach is to effectively balance comprehensiveness with expense. The approach begins with the acquisition of high-resolution digital terrain data for the site. These data are used in computational and visual analyses to determine the best locations for a reference tower and several satellite towers used for wind measurements. The reference tower has wind sensors at three levels: 20, 30, and 40 m. The satellite towers have one sensor at 30 m. The sensors measure the vertical wind speed as well as the horizontal speed and direction. The sampling rate must be at least 4 times per second. The data acquisition system keeps track of turbulence statistics that are saved at intervals from ten minutes to one hour. Statistics for the 30-m level at the satellite towers, as well as the reference tower, provide the mean and variance of the total speed and covariances of the component speeds. The data base produced by this approach over 1-2 years should be valuable for both routine and in-depth analyses. This approach takes advantage of some recent technological developments. It is not being proposed as a standard at this time, but as a tool to be refined with experience.

  6. Role of Physical Evaluation in the Early Identification of Axial Spondyloarthritis: A Research Proposal

    PubMed Central

    Castro, Marcelo P; Stebbings, Simon M; Milosavljevic, Stephan; Bussey, Melanie D

    2015-01-01

    The aim of this study was to present a rationale to explore the use of clinical tests for the sacroiliac joints to detect early axial spondyloarthritis (SpA) and to suggest a protocol to validate these clinical tests. Based on the European Guidelines for Diagnosis and Treatments of Pelvic Girdle Pain, we propose a set of six clinical tests to identify the likely presence of inflammation in the sacroiliac joints associated with early axial SpA. As magnetic resonance imaging (MRI) is the current gold standard used to identify inflammation in the sacroiliac joints, the results of the proposed set of clinical tests are compared with those from the MRI examinations. We hypothesize that specific clinical tests, which combine pain provocation and functional tests, for assessing the sacroiliac joints will help to identify early active inflammation at the sacroiliac joints in axial SpA. If such tests prove to be sensitive and specific, they could add further value to the diagnostic classification criteria for axial SpA. PMID:26448694

  7. [Cervical cancer as a tracer condition: a proposal for evaluation of primary health care].

    PubMed

    Bottari, Clarissa Moraes de Sousa; Vasconcellos, Miguel Murat; Mendonça, Maria Helena Magalhães de

    2008-01-01

    The use of tracer conditions as an evaluative technique suggests the possibility of inferring the quality of health care and setting evaluation standards for programmed actions. As a government strategy, primary health care is a key element for reorganization of the Brazilian health care model. This study analyzes the use of cervical cancer as a tracer condition for assessing primary care. Based on the results from questions on measures to control the disease from the perspective of health professionals and cervical cancer patients, we constructed a matrix of indicators relating primary care attributes to process/results indicators. The analytical plan to validate the results used triangulation of methods, associating data from qualitative and quantitative approaches, in addition to combining and cross-analyzing the various actors' points of view. The results suggest that cervical cancer is an excellent tracer condition for primary care in general, based on the similarity of such concepts as accessibility, coverage, comprehensiveness, technical and scientific quality, and effectiveness.

  8. Evaluation of Dredged Material Proposed for Ocean Disposal from Port Chester, New York

    SciTech Connect

    Barrows, E.S.; Mayhew, H.L.; Word, J.Q.; Tokos, J.J.S.

    1996-08-01

    Port Chester was one of seven waterways that the US Army Corps of Engineers-New York District requested the Battelle Marine Sciences Laboratory to sample and evaluate for dredging and disposal in March 1994. Tests and analyses were conducted on Port Chester sediment core samples. Because the Port Chester area is located on the border between New York and southeast Connecticut, its dredged material may also be considered for disposal at the Central Long Island Sound Disposal Site. The sediment evaluation consisted of bulk sediment chemical analyses, chemical analyses of site water and dredged material elutriate preparations, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Port Chester were analyzed for grain size, moisture content, and total organic carbon. In addition, sediment was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl congers, polynuclear aromatic hydrocarbons and 1,4-dichlorobenzene.

  9. Influencing factors and a proposed evaluation methodology for predicting groundwater contamination potential from stormwater infiltration activities.

    PubMed

    Clark, Shirley E; Pitt, Robert

    2007-01-01

    To offset the detrimental effects of urbanization on groundwater recharge, stormwater managers are focusing on infiltrating much of the runoff from a site that was generated because of development. For this to be effective, tools are required to predict the potential for contamination resulting from this infiltration for many site conditions, because infiltration should be stressed in areas where the least potential for causing groundwater contamination exists. Factors that influence contamination potential include the pollutant concentration in the runoff directed to the infiltration device and the ability of the underlying soil to remove the pollutant. The groundwater contamination potential of some pollutants, even those with high concentrations and moderate-to-high mobilities, can be reduced with proper pretreatment before infiltration. This paper presents a methodology that can be used to evaluate infiltration as an management option and introduces two different levels of models that could be used to evaluate contamination potential.

  10. Evaluation of exposure in mammography: limitations of average glandular dose and proposal of a new quantity.

    PubMed

    Geeraert, N; Klausz, R; Muller, S; Bloch, I; Bosmans, H

    2015-07-01

    The radiation risk in mammography is traditionally evaluated using the average glandular dose. This quantity for the average breast has proven to be useful for population statistics and to compare exposure techniques and systems. However it is not indicating the individual radiation risk based on the individual glandular amount and distribution. Simulations of exposures were performed for six appropriate virtual phantoms with varying glandular amount and distribution. The individualised average glandular dose (iAGD), i.e. the individual glandular absorbed energy divided by the mass of the gland, and the glandular imparted energy (GIE), i.e. the glandular absorbed energy, were computed. Both quantities were evaluated for their capability to take into account the glandular amount and distribution. As expected, the results have demonstrated that iAGD reflects only the distribution, while GIE reflects both the glandular amount and distribution. Therefore GIE is a good candidate for individual radiation risk assessment.

  11. Test and evaluation protocols for GPR-based mine-detection systems: a proposal

    NASA Astrophysics Data System (ADS)

    Rhebergen, Jan B.; Ralston, James M.

    2005-06-01

    With the emergence of commercially available multisensor mine detection systems, the need for standardised test and evaluation procedures becomes more pressing. For metal detectors this already has been established and is laid down in the CEN workshop document CWA14747:2003. The ITEP multisensor working group has taken the first step towards a similar document, by means of a so called "best practice" document, which would ultimately lead to a proper standard. In this paper we address various issues important for multisensor mine detection testing and evaluation and in this way hope to contribute to a draft version of the "best practice" document encouraging other parties to do the same and hence speed up the process of standardisation.

  12. Building 12-42F modification, Pantex Plant, Amarillo, Texas

    SciTech Connect

    Not Available

    1991-02-01

    The Environment Assessment (EA) has been prepared pursuant to the implementing regulations to the National Environmental Policy Act (NEPA), which require federal agencies to assess the environmental impacts of a proposed action to determine whether that action requires the preparation of an Environmental Impact Statement (EIS) or if a Finding of No Significant Impact (FONSI) can be issued. NEPA requires that an EA provide an interdisciplinary review of the proposed action in order to identify possible preferable alternatives and to identify mitigative measures that will prevent environmental impacts. If it is determined that the proposed action will have unavoidable significant environmental impact, then as EIS shall be prepared. The proposed project is to modify Building 12-42F and entry into the Sandia Pantex Weapons Evaluation Test Laboratory. The modification's primary function is to provide additional space for testing and monitoring equipment to support the activities in the existing Building 12-42F. The modification will also facilitate the reconfiguration of the personnel offices, break room and conference area. The proposed Building 12-42F modification relates to the interiors of Buildings 12-42F and 12-42A. These buildings contain a centrifuge and associated testing and monitoring equipment. The proposed addition will encompass the existing entry into Building 12-42A. Building 12-42A will be accessed through the proposed Building 12-42F modification.

  13. Population Sensitivity Evaluation of Two Proposed Hampton Roads Area Sites for a Possible Small Modular Reactor

    SciTech Connect

    Belles, R. J.; Omitaomu, O. A.

    2014-08-01

    The overall objective of this research project is to use the OR-SAGE tool to support the US Department of Energy (DOE) Office of Nuclear Energy (NE) in evaluating future electrical generation deployment options for small modular reactors (SMRs) in areas with significant energy demand from the federal sector. Deployment of SMRs in zones with high federal energy use can provide a means of meeting federal clean energy goals.

  14. Evaluation of dredged material proposed for discharge in waters of the US - testing manual. Inland testing manual

    SciTech Connect

    1998-02-01

    U.S. Army Corps of Engineers (Corps) and Environmental Protection Agency (EPA) document Evaluation of Dredged Material Proposed for Discharge in Waters of the U.S. - Testing Manual. This document is commonly referred to as the Inland Testing Manual (ITM). The purpose of the ITM is to provide guidance regarding technical protocols under Section 404 of the Clean Water Act (CWA) for evaluating proposed discharges of dredged material associated with navigational dredging projects into waters of the United States. This memorandum provides background information on the ITM, describes its scope and applicability, and outlines a schedule for its implementation. In accordance with that schedule, the ITM will be phased in over the next 18 months.

  15. Proposal of global flood vulnerability scenarios for evaluating future potential flood losses

    NASA Astrophysics Data System (ADS)

    Kinoshita, Y.; Tanoue, M.; Watanabe, S.; Hirabayashi, Y.

    2015-12-01

    Flooding is one of the most hazardous and damaging natural disasters causing serious economic loss and casualties across the world (Jongman et al., 2015). Previous studies showed that the global temperature increase affects regional weather pattern, and several general circulation model (GCM) simulations suggest the increase of flood events in both frequency and magnitude in many parts of the world (Hirabayashi et al., 2013). Effective adaptation to potential flood risks under the warming climate requires an in-depth understanding of both the physical and socioeconomic contributors of the flood risk. To assess the realistic future potential flood risk, future sophisticated vulnerability scenarios associated with the shared socioeconomic pathways (SSPs) are necessary. In this study we propose a new future vulnerability scenarios in mortality. Our vulnerability scenarios are constructed based on the modeled flood exposure (population potentially suffered by flooding) and a past from 1980 to 2005. All the flood fatality data were classified according to four income levels (high, mid-high, mid-low and low). Our proposed scenarios have three pathways regarding to SSPs; High efficiency (HE) scenario (SSP1, SSP4 (rich country) and SSP5), Medium efficiency (ME) scenario (SSP2), and Low efficiency (LE) scenario (SSP3 and SSP4 (poor country)). The maximum mortality protection level on each category was detected by applying exponential curve fitting with offset term. Slopes in the HE scenario are assumed to be equal to slopes estimated by regression analysis in each category. The slope in the HE scenario is defined by the mean value of all countries' slope value that is approximately -0.33 mortality decreases per year. The EM-DAT mortality data shows a decreasing trend in time in almost all of the countries. Although mortalities in some countries show an increasing trend, this is because these countries were affected by once-in-hundred-years floods after 1990's. The slope in

  16. Health surveillance: proposal for a tool to evaluate technological arrangements in local health systems.

    PubMed

    Silva, Gerluce Alves Pontes da; Vieira-da-Silva, Ligia Maria

    2008-11-01

    In order to identify the various meanings ascribed to health surveillance, the authors conducted a systematic review of articles published from January 1990 to August 2005 in the following databases: LILACS, SciELO, CAPES, MEDLINE, and Web of Science. A total of 144 abstracts were read and 18 full texts of Brazilian articles were selected for in-depth analysis, leading to the design of a typology for technological arrangements related to the various meanings: (i) traditional epidemiological surveillance, with communicable diseases as the main object; (ii) public health surveillance, as the municipal component of the national health surveillance system; and (iii) health surveillance, a technological mode of organizing health practices in a given territory. The proposed typology can contribute to research on surveillance practices in local health systems. It can also serve as a template for data collection and analysis. The meanings ascribed to the three types are discussed in light of public health's historical development as a field. PMID:19009127

  17. Statistical hypothesis testing by weak-value amplification: Proposal and evaluation

    NASA Astrophysics Data System (ADS)

    Susa, Yuki; Tanaka, Saki

    2015-07-01

    We study the detection capability of the weak-value amplification on the basis of the statistical hypothesis testing. We propose a reasonable testing method in the physical and statistical senses to find that the weak measurement with the large weak value has the advantage to increase the detection power and to reduce the possibility of missing the presence of interaction. We enhance the physical understanding of the weak value and mathematically establish the significance of the weak-value amplification. Our present work overcomes the critical dilemma of the weak-value amplification that the larger the amplification is, the smaller the number of data becomes, because the statistical hypothesis testing works even for a small number of data. This is contrasted with the parameter estimation by the weak-value amplification in the literature which requires a large number of data.

  18. A proposed USAF fatigue evaluation program based upon recent systems experience

    NASA Technical Reports Server (NTRS)

    Haviland, G. P.; Purkey, G. F.

    1972-01-01

    The United States Air Force has published a document entitled Aircraft Structural Integrity Program. One phase of the program is concerned with the fatigue life certification of all types of military aircraft. The document describes the criteria, analyses, and tests that are necessary in order to satisfy the USAF fatigue life requirement. Some recent and valid criticism has been directed toward the document, particularly the fatigue-life requirements contained in it. Some changes are proposed based on surveys conducted in the United States and abroad as well as some recent systems' experience. The surveys covered both military and civilian organizations. The fatigue certification case histories of selected military and commercial aircraft are presented. The design development element tests, preproduction design verification tests, and full-scale fatigue tests of each are described. A brief status report on the revisions to the MIL-A-008860 series specifications is included.

  19. TWRS Privatization Phase I waste characterization data evaluation for the request for proposal

    SciTech Connect

    Patello, G.K.; Wiemers, K.D.

    1996-09-01

    Radioactive wastes have been stored in large underground tanks at Hanford since 1944. In 1991, The Tank Waste Remediation System (TWRS) program was established to manage, retrieve, treat, immobilize, and dispose of these wastes in a safe, effective manner. DOE believes that it is feasible to privatize portions of the TWRS program. Under the Privatization strategy embodied in the request for proposal, DOE will purchase services from a contractor-owned, contractor-operated facility under a fixed-price type of contract. Phase I is a proof-of- concept/commercial demonstration-scale effort. Method used to achieve the objective of producing a technically reviewed inventory is outlined. Organic speciation and physical properties were gathered for the tank wastes and may be found in the individual tank section of this document; reference reviews and tank volume and sampling summary graphs are also provided for each tank.

  20. CFD for evaluation and treatment planning of aneurysms: review of proposed clinical uses and their challenges.

    PubMed

    Chung, Bongjae; Cebral, Juan Raul

    2015-01-01

    Computational fluid dynamics (CFD) has been used for several years to identify mechanical risk factors associated with aneurysmal evolution and rupture as well as to understand flow characteristics before and after surgical treatments in order to help the clinical decision making process. We used the keywords, "CFD" and "aneurysms" to search recent publications since about 2000, and categorized them into (i) studies of rupture risk factors and (ii) investigations of pre- and post-evaluations of surgical treatment with devices like coils and flow diverters (FD). This search enables us to examine the current status of CFD as a clinical tool and to determine if CFD can potentially become an important part of the routine clinical practice for the evaluation and treatment of aneurysms in near future. According to previous reports, it has been argued that CFD has become a quite robust non-invasive tool for the evaluation of surgical devices, especially in the early stages of device design and it has also been applied successfully to the study of rupture risk assessment. However, we find that due to the large number of pre-processing inputs further efforts of validation and reproducibility of CFD with larger clinical datasets are still essential to identify standardized mechanical risk factors. As a result, we identify the following needs to have a robust CFD tool for clinical use: (i) more reliability tests through validation studies, (ii) analyses of larger generalized clinical datasets to find converging universal risk parameters, (iii) fluid structure interaction (FSI) analyses to better understand the detailed vascular remodeling processes associated with aneurysm growth, evolution and rupture, and (iv) better coordinated and organized communications and collaborations between engineers and clinicians.

  1. Isothermal Microcalorimetric Evaluation of Compatibility of Proposed Injector Materials with High-Test Hydrogen Peroxide Propellant

    NASA Technical Reports Server (NTRS)

    Gostowski, Rudy

    2003-01-01

    High-test hydrogen peroxide (HTP) is receiving renewed interest as a monopropellant and as the oxidizer for bipropellant systems. HTP is hydrogen peroxide in concentrations ranging from 70 to 98%. All surfaces wetted by HTP must be evaluated for compatibility with the fluid. In the case of tanks, lines and valves compatibility is required to preserve the HTP oxygen and energy content and to avoid overpressurization due to decomposition. With injectors and regenerative cooling passages shorter exposure time reduces these concerns. However, phase changes from fluid to gas impact heat transfer and become the dominant compatibility concern. Isothermal microcalorimetry (IMC) provides a convenient and reproducible means to observe the decomposition of HTP when exposed to structural materials and therefore the compatibility of those materials'. The instrument provides heat flow values in terms of watts that may be converted to a reaction rate given the heat of reaction for the decomposition of hydrogen peroxide. These values are then converted to percent active oxygen loss per week (%AOL/wk) to preserve an earlier convention for quantifying HTP compatibility. Additionally, qualitative designations of compatibility have been assigned to these values. This scheme consists of four classes with Class 1 being the most compatible. While historical compatibility data is available its current applicability is in question due to subtle changes in the compositions of both HTP and structural materials. Trace levels of molecules can have significant influence on compatibility. Therefore representative samples of materials must be evaluated with current HTP formulations. In this work seven materials were selected for their strength characteristics at high temperature as expected in a HTP injector. The materials were then evaluated by IMC for HTP compatibility.

  2. A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections.

    PubMed

    Danis-Wlodarczyk, Katarzyna; Vandenheuvel, Dieter; Jang, Ho Bin; Briers, Yves; Olszak, Tomasz; Arabski, Michal; Wasik, Slawomir; Drabik, Marcin; Higgins, Gerard; Tyrrell, Jean; Harvey, Brian J; Noben, Jean-Paul; Lavigne, Rob; Drulis-Kawa, Zuzanna

    2016-01-01

    Bacteriophage therapy is currently resurging as a potential complement/alternative to antibiotic treatment. However, preclinical evaluation lacks streamlined approaches. We here focus on preclinical approaches which have been implemented to assess bacteriophage efficacy against Pseudomonas biofilms and infections. Laser interferometry and profilometry were applied to measure biofilm matrix permeability and surface geometry changes, respectively. These biophysical approaches were combined with an advanced Airway Surface Liquid infection model, which mimics in vitro the normal and CF lung environments, and an in vivo Galleria larvae model. These assays have been implemented to analyze KTN4 (279,593 bp dsDNA genome), a type-IV pili dependent, giant phage resembling phiKZ. Upon contact, KTN4 immediately disrupts the P. aeruginosa PAO1 biofilm and reduces pyocyanin and siderophore production. The gentamicin exclusion assay on NuLi-1 and CuFi-1 cell lines revealed the decrease of extracellular bacterial load between 4 and 7 logs and successfully prevents wild-type Pseudomonas internalization into CF epithelial cells. These properties and the significant rescue of Galleria larvae indicate that giant KTN4 phage is a suitable candidate for in vivo phage therapy evaluation for lung infection applications. PMID:27301427

  3. Proposal to optimize ecotoxicological evaluation of wastewater treated by conventional biological and ozonation processes.

    PubMed

    Wigh, Adriana; Devaux, Alain; Brosselin, Vanessa; Gonzalez-Ospina, Adriana; Domenjoud, Bruno; Aït-Aïssa, Selim; Creusot, Nicolas; Gosset, Antoine; Bazin, Christine; Bony, Sylvie

    2016-02-01

    A mixture of urban and hospital effluents (50% v/v) was evaluated for ecotoxicity with an advanced bioassay battery. Mixed effluents were tested before any treatment, after biological treatment alone, and after biological treatment followed by a tertiary ozonation (15 mg O3/L). Laying a high value on the continuance of organisms' fitness, essential to preserve a healthy receiving ecosystem, the main objective of this study was to combine normalized bioassays with newly developed in vivo and in vitro tests in order to assess alteration of embryo development, growth and reproduction, as well as genotoxic effects in aquatic organisms exposed to complex wastewater effluents. Comparison of the bioassays sensitivity was considered. Contrary to the lack of toxicity observed with normalized ecotoxicity tests, endpoints measured on zebrafish embryos such as developmental abnormalities and genotoxicity demonstrated a residual toxicity in wastewater both after a biological treatment followed or not by a tertiary O3 treatment. However, the ozonation step allowed to alleviate the residual endocrine disrupting potential measure in the biologically treated effluent. This study shows that normalized bioassays are not sensitive enough for the ecotoxicological evaluation of wastewaters and that there is a great need for the development of suitable sensitive bioassays in order to characterize properly the possible residual toxicity of treated effluents.

  4. A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections

    NASA Astrophysics Data System (ADS)

    Danis-Wlodarczyk, Katarzyna; Vandenheuvel, Dieter; Jang, Ho Bin; Briers, Yves; Olszak, Tomasz; Arabski, Michal; Wasik, Slawomir; Drabik, Marcin; Higgins, Gerard; Tyrrell, Jean; Harvey, Brian J.; Noben, Jean-Paul; Lavigne, Rob; Drulis-Kawa, Zuzanna

    2016-06-01

    Bacteriophage therapy is currently resurging as a potential complement/alternative to antibiotic treatment. However, preclinical evaluation lacks streamlined approaches. We here focus on preclinical approaches which have been implemented to assess bacteriophage efficacy against Pseudomonas biofilms and infections. Laser interferometry and profilometry were applied to measure biofilm matrix permeability and surface geometry changes, respectively. These biophysical approaches were combined with an advanced Airway Surface Liquid infection model, which mimics in vitro the normal and CF lung environments, and an in vivo Galleria larvae model. These assays have been implemented to analyze KTN4 (279,593 bp dsDNA genome), a type-IV pili dependent, giant phage resembling phiKZ. Upon contact, KTN4 immediately disrupts the P. aeruginosa PAO1 biofilm and reduces pyocyanin and siderophore production. The gentamicin exclusion assay on NuLi-1 and CuFi-1 cell lines revealed the decrease of extracellular bacterial load between 4 and 7 logs and successfully prevents wild-type Pseudomonas internalization into CF epithelial cells. These properties and the significant rescue of Galleria larvae indicate that giant KTN4 phage is a suitable candidate for in vivo phage therapy evaluation for lung infection applications.

  5. A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections

    PubMed Central

    Danis-Wlodarczyk, Katarzyna; Vandenheuvel, Dieter; Jang, Ho Bin; Briers, Yves; Olszak, Tomasz; Arabski, Michal; Wasik, Slawomir; Drabik, Marcin; Higgins, Gerard; Tyrrell, Jean; Harvey, Brian J.; Noben, Jean-Paul; Lavigne, Rob; Drulis-Kawa, Zuzanna

    2016-01-01

    Bacteriophage therapy is currently resurging as a potential complement/alternative to antibiotic treatment. However, preclinical evaluation lacks streamlined approaches. We here focus on preclinical approaches which have been implemented to assess bacteriophage efficacy against Pseudomonas biofilms and infections. Laser interferometry and profilometry were applied to measure biofilm matrix permeability and surface geometry changes, respectively. These biophysical approaches were combined with an advanced Airway Surface Liquid infection model, which mimics in vitro the normal and CF lung environments, and an in vivo Galleria larvae model. These assays have been implemented to analyze KTN4 (279,593 bp dsDNA genome), a type-IV pili dependent, giant phage resembling phiKZ. Upon contact, KTN4 immediately disrupts the P. aeruginosa PAO1 biofilm and reduces pyocyanin and siderophore production. The gentamicin exclusion assay on NuLi-1 and CuFi-1 cell lines revealed the decrease of extracellular bacterial load between 4 and 7 logs and successfully prevents wild-type Pseudomonas internalization into CF epithelial cells. These properties and the significant rescue of Galleria larvae indicate that giant KTN4 phage is a suitable candidate for in vivo phage therapy evaluation for lung infection applications. PMID:27301427

  6. EMF exposure assessment in the Finnish garment industry: evaluation of proposed EMF exposure metrics.

    PubMed

    Hansen, N H; Sobel, E; Davanipour, Z; Gillette, L M; Niiranen, J; Wilson, B W

    2000-01-01

    Recently published studies indicate that having worked in occupations that involve moderate to high electromagnetic field (EMF) exposure is a risk factor for neurodegenerative diseases, including Alzheimer's disease. In these studies, the occupational groups most over-represented for EMF exposure comprised seamstresses, dressmakers, and tailors. Future epidemiologic studies designed to evaluate the possibility of a causal relationship between exposure to EMF and a neuro degenerative disease endpoint such as incidence of Alzheimer's disease, will benefit from the measurement of electromagnetic field metrics with potential biological relevance. Data collection methodology in such studies would be highly dependent upon how the metrics are defined. In this research the authors developed and demonstrated (1) protocols for collecting EMF exposure data suitable for estimating a variety of exposure metrics that may have biological relevance, and (2) analytical methods for calculation of these metrics. The authors show how exposure might be estimated under each of the three prominent EMF health-effects mechanism theories and evaluate the assertion that relative exposure ranking is dependent on which mechanism is assumed. The authors also performed AC RMS magnetic flux density measurements, confirming previously reported findings. The results indicate that seamstresses, as an occupational group, should be considered for study of the possible health effects of long-term EMF exposure.

  7. The British Climate Change Act: a critical evaluation and proposed alternative approach

    NASA Astrophysics Data System (ADS)

    Pielke, Roger A., Jr.

    2009-04-01

    This paper evaluates the United Kingdom's Climate Change Act of 2008 in terms of the implied rates of decarbonization of the UK economy for a short-term and a long-term target established in law. The paper uses the Kaya identity to structure the evaluation, employing both a bottom up approach (based on projections of future UK population, economic growth, and technology) and a top down approach (deriving implied rates of decarbonization consistent with the targets and various rates of projected economic growth). Both approaches indicate that the UK economy would have to achieve annual rates of decarbonization in excess of 4 or 5%. To place these numbers in context, the UK would have to achieve the 2006 carbon efficiency of France by about 2015, a level of effort comparable to the building of about 30 new nuclear power plants, displacing an equivalent amount of fossil energy. The paper argues that the magnitude of the task implied by the UK Climate Change Act strongly suggests that it is on course to fail, and discusses implications.

  8. Comparative evaluation of the canal curvature modifications after instrumentation with One Shape rotary and Wave One reciprocating files

    PubMed Central

    Dhingra, Anil; Kochar, Rohit; Banerjee, Satyabrat; Srivastava, Punit

    2014-01-01

    Aims: This study compared the canal curvature modifications after instrumentation with One Shape (Micro Mega) rotary file and Wave One primary reciprocating file (Dentsply Maillefer, Ballaigues, Switzerland). Materials and Methods: Thirty International Organization for Standardization 15, 0.02 taper, Endo Training Blocks (Dentsply Maillefer) were used. In all specimens working length (WL) was established at the reference point 0. Glide path was achieved with Path-File 1, 2 and 3 (Dentsply Maillefer) at the WL. Group 1 were shaped with One Shape file and group 2 with Wave One files. Pre and post-digital images were superimposed, processed with Corel draw Graphic Suite X5 (Corel Corporation, Ottawa, Canada), Adobe Photoshop CS3 (Adobe Systems Inc., San Jose, CA) and Solid works student Edition software (Dassault Systems Solid Works Corp, S.A., Velizy, France). Results: Mean was more for Wave One compared with One Shape. One-way ANOVA and t-test showed a significant difference between One Shape and Wave One at 5% level of significance (P < 0.05). Conclusions: Canals prepared with Wave One file preserved canal shape, respected the anatomical shape of J-shaped canal and produced a continuously tapered funnel. PMID:24778509

  9. Safety evaluations under the proposed US Safe Cosmetics and Personal Care Products Act of 2013: animal use and cost estimates.

    PubMed

    Knight, Jean; Rovida, Costanca

    2014-01-01

    The proposed Safe Cosmetics and Personal Care Products Act of 2013 calls for a new evaluation program for cosmetic ingredients in the US, with the new assessments initially dependent on expanded animal testing. This paper considers possible testing scenarios under the proposed Act and estimates the number of test animals and cost under each scenario. It focuses on the impact for the first 10 years of testing, the period of greatest impact on animals and costs. The analysis suggests the first 10 years of testing under the Act could evaluate, at most, about 50% of ingredients used in cosmetics. Testing during this period would cost about $ 1.7-$ 9 billion and 1-11.5 million animals. By test year 10, alternative, high-throughput test methods under development are expected to be available, replacing animal testing and allowing rapid evaluation of all ingredients. Given the high cost in dollars and animal lives of the first 10 years for only about half of ingredients, a better choice may be to accelerate development of high-throughput methods. This would allow evaluation of 100% of cosmetic ingredients before year 10 at lower cost and without animal testing. PMID:24468774

  10. Safety evaluations under the proposed US Safe Cosmetics and Personal Care Products Act of 2013: animal use and cost estimates.

    PubMed

    Knight, Jean; Rovida, Costanca

    2014-01-01

    The proposed Safe Cosmetics and Personal Care Products Act of 2013 calls for a new evaluation program for cosmetic ingredients in the US, with the new assessments initially dependent on expanded animal testing. This paper considers possible testing scenarios under the proposed Act and estimates the number of test animals and cost under each scenario. It focuses on the impact for the first 10 years of testing, the period of greatest impact on animals and costs. The analysis suggests the first 10 years of testing under the Act could evaluate, at most, about 50% of ingredients used in cosmetics. Testing during this period would cost about $ 1.7-$ 9 billion and 1-11.5 million animals. By test year 10, alternative, high-throughput test methods under development are expected to be available, replacing animal testing and allowing rapid evaluation of all ingredients. Given the high cost in dollars and animal lives of the first 10 years for only about half of ingredients, a better choice may be to accelerate development of high-throughput methods. This would allow evaluation of 100% of cosmetic ingredients before year 10 at lower cost and without animal testing.

  11. A lightweight security scheme for wireless body area networks: design, energy evaluation and proposed microprocessor design.

    PubMed

    Selimis, Georgios; Huang, Li; Massé, Fabien; Tsekoura, Ioanna; Ashouei, Maryam; Catthoor, Francky; Huisken, Jos; Stuyt, Jan; Dolmans, Guido; Penders, Julien; De Groot, Harmke

    2011-10-01

    In order for wireless body area networks to meet widespread adoption, a number of security implications must be explored to promote and maintain fundamental medical ethical principles and social expectations. As a result, integration of security functionality to sensor nodes is required. Integrating security functionality to a wireless sensor node increases the size of the stored software program in program memory, the required time that the sensor's microprocessor needs to process the data and the wireless network traffic which is exchanged among sensors. This security overhead has dominant impact on the energy dissipation which is strongly related to the lifetime of the sensor, a critical aspect in wireless sensor network (WSN) technology. Strict definition of the security functionality, complete hardware model (microprocessor and radio), WBAN topology and the structure of the medium access control (MAC) frame are required for an accurate estimation of the energy that security introduces into the WBAN. In this work, we define a lightweight security scheme for WBAN, we estimate the additional energy consumption that the security scheme introduces to WBAN based on commercial available off-the-shelf hardware components (microprocessor and radio), the network topology and the MAC frame. Furthermore, we propose a new microcontroller design in order to reduce the energy consumption of the system. Experimental results and comparisons with other works are given.

  12. Evaluation of dredged material proposed for ocean disposal from Gravesend Bay Anchorage, New York

    SciTech Connect

    Barrows, E.S.; Gruendell, B.D.

    1996-09-01

    The Gravesend Bay Anchorage was one of seven waterways that the US Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in February 1994. Sediment samples were submitted for physical and chemical analyses to provide baseline sediment chemistry data on the Gravesend Bay Anchorage. Individual sediment core samples collected at the Gravesend Bay Anchorage were analyzed for grain size, moisture content, and total organic carbon (TOC). Two samples, one of composited sediment cores representing the southeast corner of the anchorage (COMP GR), and one sediment core representing the northeast corner of the anchorage (Station GR-1 0), were analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4-dichlorobenzene.

  13. 23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... volumes, or daily vehicular traffic on one or more principal routes that serve the intermodal facility.... Proposed additions should connect at each end with other routes on the NHS or serve a major traffic... to add routes to the NHS should include information on the type of traffic served (i.e., percent...

  14. Evaluation of Proposed Solutions to Global Warming, Air Pollution, and Energy Security

    NASA Astrophysics Data System (ADS)

    Jacobson, M. Z.

    2008-12-01

    This study reviews and ranks major proposed solutions to global warming, air pollution mortality, and energy security while considering other impacts of the proposed solutions, such as on water supply, land use, wildlife, resource availability, thermal pollution, water chemical pollution, nuclear proliferation, and undernutrition. Nine electric power sources and two liquid fuel options are considered. The electricity sources include solar-photovoltaics (PV), concentrated solar power (CSP), wind, geothermal, hydroelectric, wave, tidal, nuclear, and coal with carbon capture and storage (CCS) technology. The liquid fuel options include corn-E85 and cellulosic E85. To place the electric and liquid fuel sources on an equal footing, we examine their comparative abilities to address the problems mentioned by powering new-technology vehicles, including battery-electric vehicles (BEVs), hydrogen fuel cell vehicles (HFCVs), and flex-fuel vehicles run on E85. Twelve combinations of energy source-vehicle type are considered. Upon ranking and weighting each combination with respect to each of 11 impact categories, four clear divisions of ranking, or tiers, emerge. Tier 1 (highest-ranked) includes wind-BEVs and wind-HFCVs. Tier 2 includes CSP-BEVs, geothermal-BEVs, PV-BEVs, tidal-BEVs, and wave-BEVs. Tier 3 includes hydro-BEVs, nuclear-BEVs, and CCS-BEVs. Tier 4 includes corn- and cellulosic-E85. Wind-BEVs ranked first in six out of 11 categories, including the two most important, mortality and climate damage reduction. Although HFCVs are less efficient than BEVs, wind- HFCVs ranked second among all combinations. Tier 2 options provide significant benefits and are recommended. Tier 3 options are less desirable. However, hydroelectricity, which was ranked ahead of coal- CCS and nuclear with respect to climate and health, is an excellent load balancer, thus strongly recommended. The Tier-4 combinations (cellulosic- and corn-E85) were ranked lowest overall and with respect to

  15. Carbonado: Physical and chemical properties, a critical evaluation of proposed origins, and a revised genetic model

    NASA Astrophysics Data System (ADS)

    Haggerty, Stephen E.

    2014-03-01

    Carbonado-diamond is the most controversial of all diamond types and is found only in Brazil, and the Central African Republic (Bangui). Neither an affinity to Earth's mantle, nor an origin in the crust can be unequivocally established. Carbonado-diamond is at least 3.8 Ga old, an age about 0.5 Ga older than the oldest diamonds yet reported in kimberlites and lamproites on Earth. Derived from Neo- to Mid-Proterozoic meta-conglomerates, the primary magmatic host rock has not been identified. Discovered in 1841, the material is polycrystalline, robust and coke-like, and is best described as a strongly bonded micro-diamond ceramic. It is characteristically porous, which precludes an origin at high pressures and high temperatures in Earth's deep interior, yet it is also typically patinated, with a glass-like surface that resembles melting. With exotic inclusions of highly reduced metals, carbides, and nitrides the origin of carbonado-diamond is made even more challenging. But the challenge is important because a new diamondiferous host rock may be involved, and the development of a new physical process for generating diamond is possibly assured. The combination of micro-crystals and random crystal orientation leads to extreme mechanical toughness, and a predicable super-hardness. The physical and chemical properties of carbonado are described with a view to the development of a mimetic strategy to synthesize carbonado and to duplicate its extreme toughness and super-hardness. Textural variations are described with an emphasis on melt-like surface features, not previously discussed in the literature, but having a very clear bearing on the history and genesis of carbonado. Selected physical properties are presented and the proposed origins, diverse in character and imaginatively novel, are critically reviewed. From our present knowledge of the dynamic Earth, all indications are that carbonado is unlikely to be of terrestrial origin. A revised model for the origin of

  16. In situ clay formation : evaluation of a proposed new technology for stable containment barriers.

    SciTech Connect

    Nagy, Kathryn L.; DiGiovanni, Anthony Albert; Fredrich, Joanne T.

    2004-03-01

    Containment of chemical wastes in near-surface and repository environments is accomplished by designing engineered barriers to fluid flow. Containment barrier technologies such as clay liners, soil/bentonite slurry walls, soil/plastic walls, artificially grouted sediments and soils, and colloidal gelling materials are intended to stop fluid transport and prevent plume migration. However, despite their effectiveness in the short-term, all of these barriers exhibit geochemical or geomechanical instability over the long-term resulting in degradation of the barrier and its ability to contain waste. No technologically practical or economically affordable technologies or methods exist at present for accomplishing total remediation, contaminant removal, or destruction-degradation in situ. A new type of containment barrier with a potentially broad range of environmental stability and longevity could result in significant cost-savings. This report documents a research program designed to establish the viability of a proposed new type of containment barrier derived from in situ precipitation of clays in the pore space of contaminated soils or sediments. The concept builds upon technologies that exist for colloidal or gel stabilization. Clays have the advantages of being geologically compatible with the near-surface environment and naturally sorptive for a range of contaminants, and further, the precipitation of clays could result in reduced permeability and hydraulic conductivity, and increased mechanical stability through cementation of soil particles. While limited success was achieved under certain controlled laboratory conditions, the results did not warrant continuation to the field stage for multiple reasons, and the research program was thus concluded with Phase 2.

  17. Calendar year 1993 groundwater quality report for the Upper East Fork Poplar Creek hydrogeologic regime Y-12 Plant, Oak Ridge, Tennessee: 1993 groundwater quality data interpretations and proposed program modifications

    SciTech Connect

    1994-10-01

    This Groundwater Quality Report (GWQR) contains an evaluation of the groundwater quality data obtained during the 1993 calendar year (CY) at the U.S. Department of Energy (DOE) Y-12 Plant located on the DOE Oak Ridge Reservation (ORR) southeast of Oak Ridge, Tennessee (Figure 1). The groundwater quality data are presented in Part 1 of the GWQR submitted by Martin Marietta Energy Systems, Inc. (Energy Systems) to the Tennessee Department of Environment and Conservation (TDEC) in February 1994 (HSW Environmental Consultants, Inc. 1994a). Groundwater quality data evaluated in this report were obtained at several hazardous and non-hazardous waste management facilities and underground storage tanks (USTS) located within the Upper East Fork Poplar Creek Hydrogeologic Regime (East Fork Regime). The Environmental Management Department of the Y-12 Plant Health, Safety, Environment, and Accountability Organization manages the groundwater monitoring activities in each regime under the auspices of the Y-12 Plant Groundwater Protection Program (GWPP). The purpose of the GWPP is to characterize the hydrogeology and to monitor groundwater quality at the Y-12 Plant and surrounding area to provide for protection of groundwater resources consistent with federal, state, and local requirements and in accordance with DOE Orders and Energy Systems corporate policy. The annual GWQR for the East Fork Regime is completed in two parts. Part 1 consists primarily of data appendices and serves as a reference for the groundwater quality data obtained each CY under the lead of the Y-12 Plant GWPP. Part 2 (this report) contains an evaluation of the data with respect to regime-wide groundwater quality, presents the findings and status of ongoing hydrogeologic studies, describes changes in monitoring priorities, and presents planned modifications to the groundwater sampling and analysis program for the following calendar year.

  18. Modification of a commercial gas chromatography isotope ratio mass spectrometer for on-line carbon isotope dilution: Evaluation of its analytical characteristics for the quantification of organic compounds.

    PubMed

    Alonso Sobrado, Laura; Robledo Fernández, Mario; Cueto Díaz, Sergio; Ruiz Encinar, Jorge; García Alonso, J Ignacio

    2015-11-01

    We describe the instrumental modification of a commercial gas chromatography isotope ratio mass spectrometer (GC-IRMS) and its application for on-line carbon isotope dilution. The main modification consisted in the addition of a constant flow of enriched (13)CO2 diluted in helium after the chromatographic column through the splitter holder located inside the chromatographic oven of the instrument. In addition, and in contrast to the conventional mode of operation of GC-IRMS instruments where the signal at m/z 45 is amplified 100-fold with respect to the signal at m/z 44, the same signal amplification was used in both Faraday cups at m/z 44 and 45. Under these conditions isotope ratio precision for the ratio 44/45 was around 0.05% RSD (n=50). The evaluation of the instrument was performed with mixtures of organic compounds including 11 n-alkanes, 16 PAHs, 12 PCBs and 3 benzothiophenes. It was observed that compounds of very different boiling points could be analysed without discrimination in the injector when a Programmable Temperature Vaporizer (PTV) injector was employed. Moreover, the presence of heteroatoms (Cl or S) in the structure of the organic compounds did not affect their combustion efficiency and therefore the trueness of the results. Quantitative results obtained for all the analytes assayed were excellent in terms of precision (<3% RSD) and accuracy (average relative error≤4%) and what is more important using a single and simple generic internal standard for quantification. PMID:26435309

  19. Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign.

    PubMed

    Schleicher, Kristin D; Sasaki, Yoshikazu; Tam, Annie; Kato, Daisuke; Duncan, Katharine K; Boger, Dale L

    2013-01-24

    The total synthesis of a systematic series of vinblastine analogues that contain deep-seated structural modifications to the core ring system of the lower vindoline subunit is described. Complementary to the vindoline 6,5 DE ring system, compounds with 5,5, 6,6, and the reversed 5,6 membered DE ring systems were prepared. Both the natural cis and unnatural trans 6,6-membered ring systems proved accessible, with the latter representing a surprisingly effective class for analogue design. Following Fe(III)-promoted coupling with catharanthine and in situ oxidation to provide the corresponding vinblastine analogues, their evaluation provided unanticipated insights into how the structure of the vindoline subunit contributes to activity. Two potent analogues (81 and 44) possessing two different unprecedented modifications to the vindoline subunit core architecture were discovered that matched the potency of the comparison natural products and both lack the 6,7-double bond whose removal in vinblastine leads to a 100-fold drop in activity.

  20. Evaluation of 'GLAMEPS'—a proposed multimodel EPS for short range forecasting

    NASA Astrophysics Data System (ADS)

    Iversen, Trond; Deckmyn, Alex; Santos, Carlos; Sattler, Kai; Bremnes, John Bjørnar; Feddersen, Henrik; Frogner, Inger-Lise

    2011-05-01

    Grand Limited Area Model Ensemble Prediction System (GLAMEPS) is prepared for pan-European, short-range probabilistic numerical weather prediction of fine synoptic-scale, quasi-hydrostatic atmospheric flows. Four equally sized ensembles are combined: EuroTEPS, a version of the global ECMWF EPS with European target; AladEPS, a downscaling of EuroTEPS using the ALADIN model; HirEPS_K and HirEPS_S, two ensembles using the HIRLAM model nested into EuroTEPS including 3DVar data-assimilation for two control forecasts. A 52-member GLAMEPS thus samples forecast uncertainty by three analysed initial states combined with 12 singular vector-based perturbations, four different models and the stochastic physics tendencies in EuroTEPS. Over a 7-week test period in winter 2008, GLAMEPS produced better results than ECMWF's EPS with 51 ensemble members. Apart from spatial resolution, the improvement is due to the multimodel combination and to a smaller extent the dedicated EuroTEPS. Ensemble resolution and reliability are both improved. Combining uncalibrated ensembles is seen to produce a better combined ensemble than the best single-model ensemble of the same size, except when one of the single-model ensembles is considerably better than the others. Bayesian Model Averaging improves reliability, but needs further elaboration to account for geographical variations. These conclusions need to be confirmed by long-period evaluations.