Science.gov

Sample records for modification proposal evaluation

  1. Evaluation of proposed panel closure modifications at WIPP

    SciTech Connect

    Allen, Lawrence E.; Silva, Matthew K.; Channell, James K.; Abel, John F.; Morgan, Dudley R.

    2001-12-31

    A key component in the design of the WIPP repository is the installation of concrete structures as panel seals in the intake and exhaust drifts after a panel has been filled with waste containers. As noted in the EPA final rule, the panel seal closure system is intended to block brine flow between the waste panels at the WIPP. On April 17, 2001, the DOE proposed seven modifications to the EPA concerning the design of the panel closure system. EPA approval of these modifications is necessary since the details of the panel design are specified in EPA’s final rule as a condition for WIPP certification. However, the EPA has not determined whether a rulemaking would be required for these proposed design modifications. On September 4, 2001, the DOE withdrew the request, noting that it would be resubmitted on a future date. The Environmental Evaluation Group (EEG) contracted with two engineers, Dr. John Abel and Dr. Rusty Morgan, to evaluate the proposed modifications. The EEG has accepted the conclusions and recommendations from these two experts: 1) replacement of Salado Mass Concrete with a generic salt-based concrete; 2) replacement of the explosion wall with a construction wall; 3) replacement of freshwater grouting with salt-based grouting; 4) option to allow surface or underground mixing; and 5) option to allow up to one year for completion of closure. The proposed modification to allow local carbonate river rock as aggregate is acceptable pending demonstration that no problems will exist in the resulting concrete. The proposed modification to give the contractor discretion in removal of steel forms is not supported. Instead, several recommendations are made to specifically reduce the number of forms left, thereby reducing potential migration pathways.

  2. Technical evaluation of the proposed design modifications and technical specification changes on grid voltage degradation (Part A) for the Pilgrim Nuclear Power Station, Unit 1

    SciTech Connect

    White, R.L.

    1980-01-01

    This report documents the technical evaluation of the proposed design modifications and Technical Specification changes for protection of Class 1E equipment from grid voltage degradation for the Pilgrim Nuclear Power Station. The review criteria are based on several IEEE standards and the Code of Federal Regulations. The evaluation compares the submittals made by the licensee with the NRC staff positions and the review criteria and presents the reviewer's conclusion on the acceptability of the proposed system.

  3. Manufacturer evaluations of endograft modifications.

    PubMed

    Waninger, Matthew S; Whirley, Robert G; Smith, Louis J; Wolf, Ben S

    2013-03-01

    The motivation to modify the design of a vascular device can arise from a number of sources. Clinical experience with the unmodified device could suggest new design modifications to improve device performance or clinical outcomes. Similarly, clinical success with a device often suggests modifications that could broaden the applicability of the device to enable treatment of different or more advanced disease states. As a specific example, both of these scenarios have arisen during the last decade in the evolution of endovascular grafts for the treatment of abdominal aortic aneurysms, with modifications enabling the treatment of patients with shorter infrarenal necks, more angulated anatomy, and smaller access vessels. These modifications have been made by manufacturers and additionally by physicians who create branched and fenestrated devices. The experience to date with the use of fenestrated devices and the development of chimney, snorkel, and periscope techniques suggests that modifications to off-the-shelf devices may provide some clinical benefit. This experience provides additional motivation for manufacturers to develop devices to address the clinical needs not met with their current product lines. For manufacturers, the device development process includes an assessment of the new device design to determine the appropriate evaluation strategy to support the safety and effectiveness of the modified device. This report provides a high-level overview of the process generally followed by device manufacturers to evaluate a proposed device modification before market release, in accordance with local country regulations and recognized international standards such as the International Organization of Standardization (ISO) standards for endovascular grafts (ISO 25539 Part 1). Copyright © 2013 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.

  4. Proposed Modification to the Plutonium Systemic Model.

    PubMed

    Konzen, Kevin; Miller, Scott; Brey, Richard

    2015-10-01

    The currently accepted biokinetic model for plutonium distribution within the human body was recommended by the International Commission on Radiological Protection in publication 67. This model was developed from human and animal studies and behavioral knowledge acquired from other known bone-seeking radionuclides. The biokinetic model provides a mathematical means of predicting the distribution, retention, and clearance of plutonium within the human body that may be used in deriving organ, tissue, and whole body dose. This work proposed a modification to the ICRP 67 systemic model for plutonium that incorporated the latest knowledge acquired from recent human injection studies with physiologically based improvements. In summary, the changes included a separation of the liver compartments, removed the intermediate soft tissue-to-bladder pathway, and added pathways from the blood compartment to both the cortical and trabecular bone volumes. The proposed model provided improved predictions for several bioassay indicators compared to the ICRP 67 model while also maintaining its basic structure. Additionally, the proposed model incorporated physiologically based improvements for the liver and skeleton and continued to ensure efficient coupling with intake biokinetic models.

  5. Aircraft Modification Management Evaluation

    DTIC Science & Technology

    1980-12-01

    Configuration Control Board Deputy for Avionics Control - Department of Defense - Full Scale Engineering Development - Fiscal Year - Major Air...and Analysis AFLC System Manager AFLC Configuratio Control Board Reviews HPA and subaits it to the Air Staff *0 Installation Preparation...management control system used to ensure that the deficiencies are evaluated and resolved by the appropriate function ele- ments. The ALC

  6. Electric utility engineer`s FGD manual -- Volume 2: Major mechanical equipment; FGD proposal evaluations; Use of FGDPRISM in FGD system modification, proposal, evaluation, and design; FGD system case study. Final report

    SciTech Connect

    1996-03-04

    Part 2 of this manual provides the electric utility engineer with detailed technical information on some of the major mechanical equipment used in the FGD system. The objectives of Part 2 are the following: to provide the electric utility engineer with information on equipment that may be unfamiliar to him, including ball mills, vacuum filters, and mist eliminators; and to identify the unique technique considerations imposed by an FGD system on more familiar electric utility equipment such as fans, gas dampers, piping, valves, and pumps. Part 3 provides an overview of the recommended procedures for evaluating proposals received from FGD system vendors. The objectives are to provide procedures for evaluating the technical aspects of proposals, and to provide procedures for determining the total costs of proposals considering both initial capital costs and annual operating and maintenance costs. The primary objective of Part 4 of this manual is to provide the utility engineer who has a special interest in the capabilities of FGDPRISM [Flue Gas Desulfurization PRocess Integration and Simulation Model] with more detailed discussions of its uses, requirements, and limitations. Part 5 is a case study in using this manual in the preparation of a purchase specification and in the evaluation of proposals received from vendors. The objectives are to demonstrate how the information contained in Parts 1 and 2 can be used to improve the technical content of an FGD system purchase specification; to demonstrate how the techniques presented in Part 3 can be used to evaluate proposals received in response to the purchase specification; and to illustrate how the FGDPRISM computer program can be used to establish design parameters for the specification and evaluate vendor designs.

  7. Technical evaluation report (Revision 1) on the proposed design modifications and technical specification changes on grid voltage degradation for the Peach Bottom Atomic Power Station, Units 2 and 3

    SciTech Connect

    Selan, J.C.

    1983-03-11

    This report is a revision of the technical evaluation documented in a separate report dated November 3, 1981 (UCID-19115) on the proposed design modification and Technical Specification changes for the protection of the Class 1E equipment from grid voltage degradation for the Peach Bottom Atomic Power Station, Units 2 and 3. The review criteria are based on several IEEE standards and The Code of Federal Regulations. The evaluation compares the submittals made by the plant with the NRC staff positions and the review criteria. The evaluation finds that the proposed design modifications and the required changes to the Technical Specifications will ensure that the Class 1E equipment will be protected from sustained voltage degradation.

  8. Project Proposals Evaluation

    NASA Astrophysics Data System (ADS)

    Encheva, Sylvia; Tumin, Sharil

    2009-08-01

    Collaboration among various firms has been traditionally used trough single project joint ventures for bonding purposes. Eventhough the performed work is usually beneficial to some extend to all participants, the type of collaboration option to be adapted is strongly influenced by overall purposes and goals that can be achieved. In order to facilitate a choice of collaboration option best suited to a firm's need a computer based model is proposed.

  9. 78 FR 59345 - Proposed Information Collection Request; Comment Request; Modification of Secondary Treatment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... AGENCY Proposed Information Collection Request; Comment Request; Modification of Secondary Treatment... request (ICR), ``Modification of Secondary Treatment Requirements for Discharges into Marine Waters... 301(h) program involves collecting information from two sources: (1) The municipal wastewater...

  10. Zone III flexor tendon injuries - A proposed modification to rehabilitation.

    PubMed

    Chinchalkar, Shrikant J; Pipicelli, Joey G; Agur, Anne; Athwal, George S

    2015-01-01

    In this manuscript, these authors have utilized years of clinical experience to suggest rehabilitation modifications for Zone III flexor tendon injuries. - VictoriaPriganc, PhD, OTR, CHT, CLT, Practice Forum Editor.

  11. Major Modification Determination Process Utilized for Proposed Idaho National Laboratory Projects

    SciTech Connect

    Michael A. Lehto, Ph.D.; Boyd D. Christensen

    2008-05-01

    Over the past three years, several new projects with the potential for major modifications to existing facilities have been considered for implementation at the Idaho National Laboratory (INL). These projects were designated to take place in existing nuclear facilities with existing documented safety analyses. 10 CFR 830.206 requires the contractor for a major modification to a Hazard Category 1, 2, or 3 nuclear facility to obtain Department of Energy (DOE) approval for the nuclear facility design criteria to be used for preparation of a preliminary documented safety analysis (PDSA), as well as creation and approval of the PDSA, before the contractor can procure materials or components or begin construction on the project. Given the significant effort and expense of preparation and approval of a PDSA, a major modification determination for new projects is warranted to determine if the rigorous requirements of a major modification are actually required. Furthermore, performing a major modification determination helps to ensure that important safety aspects of a project are appropriately considered prior to modification construction or equipment procurement. The projects considered for major modification status at the INL included: treatment and packaging of unirradiated, sodium-bonded highly enriched uranium (HEU) fuel and miscellaneous casting scrap in the Materials and Fuels Complex (MFC) Fuel Manufacturing Facility (FMF); post irradiation examination of Advance Fuel Cycle Initiative (AFCI) fuel in the MFC Analytical Laboratory (AL); the Advanced Test Reactor (ATR) gas test loop (GTL); and the hydraulic shuttle irradiation system (HSIS) at ATR. The major modification determinations for three of the proposed projects resulted in a negative major modification. On the other hand, the major modification determination for the GTL project concluded that the project would require a major modification. This paper discusses the process, methods, and considerations used by

  12. 48 CFR 415.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Proposal evaluation. 415... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 415.305 Proposal evaluation. HCAs... of the technical evaluation team. ...

  13. 48 CFR 1315.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 1315... AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1315.305 Proposal evaluation. At the... evaluation team. ...

  14. 48 CFR 2415.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 2415... Proposal evaluation. (a) After receipt of proposals, the Contracting Officer will forward copies of the... each proposal shall be retained by the Contracting Officer pending initial technical evaluation by the...

  15. 48 CFR 515.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... proposal abstract: (1) This proposal must be used and disclosed for evaluation purposes only. (2) You must apply a copy of this Government notice to any reproduction or abstract of this proposal. (3) You must...

  16. Classification of parotidectomy: a proposed modification to the European Salivary Gland Society classification system.

    PubMed

    Wong, Wai Keat; Shetty, Subhaschandra

    2017-08-01

    Parotidectomy remains the mainstay of treatment for both benign and malignant lesions of the parotid gland. There exists a wide range of possible surgical options in parotidectomy in terms of extent of parotid tissue removed. There is increasing need for uniformity of terminology resulting from growing interest in modifications of the conventional parotidectomy. It is, therefore, of paramount importance for a standardized classification system in describing extent of parotidectomy. Recently, the European Salivary Gland Society (ESGS) proposed a novel classification system for parotidectomy. The aim of this study is to evaluate this system. A classification system proposed by the ESGS was critically re-evaluated and modified to increase its accuracy and its acceptability. Modifications mainly focused on subdividing Levels I and II into IA, IB, IIA, and IIB. From June 2006 to June 2016, 126 patients underwent 130 parotidectomies at our hospital. The classification system was tested in that cohort of patient. While the ESGS classification system is comprehensive, it does not cover all possibilities. The addition of Sublevels IA, IB, IIA, and IIB may help to address some of the clinical situations seen and is clinically relevant. We aim to test the modified classification system for partial parotidectomy to address some of the challenges mentioned.

  17. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 915... AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation. (d... operate Government-owned facilities, may be used in the evaluation process as evaluators or advisors when...

  18. [Gardnerella vaginalis biotypes: modification of a proposed system].

    PubMed

    Pedraza-Avilés, A G; Inzunza-Montiel, A E; Ortíz-Zaragoza, M C; Morales-Espinosa, M R; Ponce-Rosas, E R

    1995-01-01

    A modified scheme is proposed for biotyping Gardnerella vaginalis based on detection of hippurate hydrolysis, beta-galactosidase (ONPG) and lipase, and fermentation of arabinose, galactose and xylose. Thirty three biotypes were found among 140 strains from women with and without bacterial vaginosis (non-specific vaginitis). The distribution of biotypes were found to be significantly different, being more predominant the biotypes 1A; 5G; 7A; 7D and 7G in women with vaginosis and the biotypes 5G and 6H in women without vaginosis. These data suggest that some biotypes of Gardnerella vaginalis are associated with bacterial vaginosis.

  19. 76 FR 18723 - Proposed Information Collection; Comment Request; Weather Modification Activities Reports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Proposed Information Collection; Comment Request; Weather... requires that persons who engage in weather modification activities (e.g., cloud seeding) provide reports...

  20. 75 FR 5704 - Proposed Modification of Jet Routes J-37 and J-55; Northeast United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Proposed Modification of Jet Routes J-37 and J-55; Northeast United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to modify Jet Routes J-37 and J-55 in...

  1. 48 CFR 1815.208 - Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., revision, and withdrawal of proposals. (NASA supplements paragraph (b)) 1815.208 Section 1815.208 Federal... Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b)) (b) The FAR late proposal criteria do not apply to Announcements of Opportunity, NASA Research Announcements, and...

  2. 48 CFR 1815.208 - Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., revision, and withdrawal of proposals. (NASA supplements paragraph (b)) 1815.208 Section 1815.208 Federal... Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b)) (b) The FAR late proposal criteria do not apply to Announcements of Opportunity, NASA Research Announcements, and...

  3. 48 CFR 15.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... contract successfully. An agency shall evaluate competitive proposals and then assess their relative... weights, and ordinal rankings. The relative strengths, deficiencies, significant weaknesses, and risks...) Past performance evaluation. (i) Past performance information is one indicator of an offeror's...

  4. 48 CFR 1515.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 1515.305 Section 1515.305 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY... evaluation. ...

  5. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 715... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 715.305 Proposal evaluation....spu@aidw/Internet: pastperformance@usaid.gov.) (b) A justification is to be written by the...

  6. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost realism...

  7. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost realism...

  8. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Proposal evaluation. 915.305 Section 915.305 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation....

  9. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Proposal evaluation. 915.305 Section 915.305 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation....

  10. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Proposal evaluation. 915.305 Section 915.305 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation....

  11. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Proposal evaluation. 915.305 Section 915.305 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation....

  12. 48 CFR 1415.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 1415.305 Section 1415.305 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1415.305 Proposal evaluation. The...

  13. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost realism...

  14. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost realism...

  15. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost realism...

  16. 75 FR 5703 - Proposed Modification of Jet Route J-3; Spokane, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Jet Route J-3; Spokane, WA AGENCY... action proposes to modify Jet Route J-3 by terminating the route at the Spokane, WA, VHF omnidirectional... to Title 14 Code of Federal Regulations (14 CFR) part 71 to remove the segment of J-3 that...

  17. 76 FR 76070 - Proposed Modification of Area Navigation Route T-288; WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Area Navigation Route T-288; WY...: This action proposes to modify low altitude area navigation (RNAV) route T-288 by extending the route... airway structure and providing alternative routing in the event of navigation aid (NAVAID) outages....

  18. 75 FR 27229 - Proposed Modification of Class B Airspace; Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class B Airspace; Chicago, IL...: This action proposes to modify the Chicago, IL, Class B airspace area by expanding the existing... procedures within Class B airspace, and segregating IFR aircraft at Chicago O'Hare International Airport (ORD...

  19. 75 FR 2582 - Proposed Modification of the Atlanta, GA, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ..., in Covington, GA, as published in the Federal Register on Friday, December 4, 2009 (74 FR 63818), FR... Federal Aviation Administration Proposed Modification of the Atlanta, GA, Class B Airspace Area; Public... Friday, December 4, 2009, concerning a proposal to revise Class B airspace at Atlanta, GA, (74 FR...

  20. 76 FR 35371 - Proposed Modification of the Las Vegas, NV, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Las Vegas, NV, Class B... information from airspace users and others, concerning a proposal to modify Class B airspace at Las Vegas, NV... Centennial Parkway, Las Vegas, NV 89149; (2) The meeting on Tuesday, August 23, 2011, will be held...

  1. 76 FR 28687 - Proposed Modification of Class E Airspace; Newcastle, WY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class E Airspace; Newcastle, WY Correction In proposed rule document 2011-8743 appearing on pages 20281-20282 in the issue of Tuesday,...

  2. 48 CFR 2015.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 2015.305 Section 2015.305 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING... evaluation. The Source Evaluation Panel shall use this information to perform an accurate...

  3. Proposed modifications of Environmental Protection Agency Method 1601 for detection of coliphages in drinking water, with same-day fluorescence-based detection and evaluation by the performance-based measurement system and alternative test protocol validation approaches.

    PubMed

    Salter, Robert S; Durbin, Gregory W; Conklin, Ernestine; Rosen, Jeff; Clancy, Jennifer

    2010-12-01

    Coliphages are microbial indicators specified in the Ground Water Rule that can be used to monitor for potential fecal contamination of drinking water. The Total Coliform Rule specifies coliform and Escherichia coli indicators for municipal water quality testing; thus, coliphage indicator use is less common and advances in detection methodology are less frequent. Coliphages are viral structures and, compared to bacterial indicators, are more resistant to disinfection and diffuse further distances from pollution sources. Therefore, coliphage presence may serve as a better predictor of groundwater quality. This study describes Fast Phage, a 16- to 24-h presence/absence modification of U.S. Environmental Protection Agency (EPA) Method 1601 for detection of coliphages in 100 ml water. The objective of the study is to demonstrate that the somatic and male-specific coliphage modifications provide results equivalent to those of Method 1601. Five laboratories compared the modifications, featuring same-day fluorescence-based prediction, to Method 1601 by using the performance-based measurement system (PBMS) criterion. This requires a minimum 50% positive response in 10 replicates of 100-ml water samples at coliphage contamination levels of 1.3 to 1.5 PFU/100 ml. The laboratories showed that Fast Phage meets PBMS criteria with 83.5 to 92.1% correlation of the same-day rapid fluorescence-based prediction with the next-day result. Somatic coliphage PBMS data are compared to manufacturer development data that followed the EPA alternative test protocol (ATP) validation approach. Statistical analysis of the data sets indicates that PBMS utilizes fewer samples than does the ATP approach but with similar conclusions. Results support testing the coliphage modifications by using an EPA-approved national PBMS approach with collaboratively shared samples.

  4. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Officer and placed in the official file to support the decision to reject all proposals and to cancel the... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Proposal evaluation. 715.305 Section 715.305 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT...

  5. 48 CFR 15.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... weights, and ordinal rankings. The relative strengths, deficiencies, significant weaknesses, and risks supporting proposal evaluation shall be documented in the contract file. (1) Cost or price evaluation... satisfy the requirement to perform a price analysis, and a cost analysis need not be performed. In...

  6. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Submission, modification, revision, and withdrawal of proposals. 315.208 Section 315.208 Federal Acquisition Regulations System... Acquisition, if an HCA determines that certain classes of biomedical or behavioral R & D acquisitions...

  7. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Submission, modification, revision, and withdrawal of proposals. 315.208 Section 315.208 Federal Acquisition Regulations System... Acquisition, if an HCA determines that certain classes of biomedical or behavioral R & D acquisitions...

  8. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Submission, modification, revision, and withdrawal of proposals. 315.208 Section 315.208 Federal Acquisition Regulations System... Acquisition, if an HCA determines that certain classes of biomedical or behavioral R & D acquisitions...

  9. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Submission, modification, revision, and withdrawal of proposals. 315.208 Section 315.208 Federal Acquisition Regulations System... Acquisition, if an HCA determines that certain classes of biomedical or behavioral R & D acquisitions...

  10. 75 FR 26891 - Proposed Modification of the Detroit, MI, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Detroit, MI, Class B Airspace Area; Public Meetings AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of public..., Federal Aviation Administration, 2601 Meacham Boulevard, Fort Worth, Texas 76137, or by fax to (817)...

  11. 78 FR 69787 - Proposed Modification of Class E Airspace; Sitka, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    .... * * * * * AAL AK E2 Sitka, AK Sitka Rocky Gutierrez Airport, AK (Lat. 57 02'50'' N., long. 135 21'42'' W..., AK (Lat. 57 02'50'' N., long. 135 21'42'' W.) That airspace extending upward from 700 feet above the... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class E Airspace; Sitka, AK AGENCY...

  12. 78 FR 740 - Availability of Draft Environmental Assessment for the Proposed Modification of the Bayonne...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ... reasonably foreseeable environmental impacts and socio-economic impacts of the proposed modification of the... Implementing Procedures and Policy for Considering Environmental Impacts. SUPPLEMENTARY INFORMATION: Public... significant impacts be discovered during the review process, the level of environmental documentation may be...

  13. 76 FR 489 - Proposed Modification of the Minneapolis, MN, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Minneapolis, MN, Class B... Minneapolis, MN. The purpose of these meetings is to provide interested parties an opportunity to present...), 6040 28th Avenue, South, Minneapolis, MN 55450. (2) The meeting on Saturday, March 19, 2011, will be...

  14. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... effectiveness of the health care system by leading to cost reductions for, or improvements in benefits from... as new services, organizations, and provider types) and information technology. (2) Specifications... additional system requirements. (3) Testing of the proposed modification. Provide an explanation, no more...

  15. 77 FR 43183 - Proposed Modification of Class E Airspace; Wolf Point, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ...-ANM-17 Proposed Modification of Class E Airspace; Wolf Point, MT AGENCY: Federal Aviation... Class E airspace at Wolf Point, MT. Controlled airspace is necessary to accommodate aircraft using Nondirectional Radio Beacon (NDB) standard instrument approach procedures at L M Clayton Airport, Wolf Point, MT...

  16. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Submission, modification, revision, and withdrawal of proposals. 315.208 Section 315.208 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION...

  17. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... (x) Incorporate flexibility to adapt more easily to changes in the health care infrastructure (such... proposed modifications. 162.940 Section 162.940 Public Welfare Department of Health and Human Services... effectiveness of the health care system by leading to cost reductions for, or improvements in benefits...

  18. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... (x) Incorporate flexibility to adapt more easily to changes in the health care infrastructure (such... proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... effectiveness of the health care system by leading to cost reductions for, or improvements in benefits...

  19. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... (x) Incorporate flexibility to adapt more easily to changes in the health care infrastructure (such... proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... effectiveness of the health care system by leading to cost reductions for, or improvements in benefits...

  20. 40 CFR 194.65 - Notice of proposed rulemaking for modification or revocation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Notice of proposed rulemaking for modification or revocation. 194.65 Section 194.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS CRITERIA FOR THE CERTIFICATION AND RE-CERTIFICATION OF THE...

  1. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... as new services, organizations, and provider types) and information technology. (2) Specifications... exception. The Secretary may grant an initial exception, for a period not to exceed 3 years, based on,...

  2. Evaluation of materials and design modifications for aircraft brakes

    NASA Technical Reports Server (NTRS)

    Ho, T. L.; Kennedy, F. E.; Peterson, M. B.

    1975-01-01

    A test program is described which was carried out to evaluate several proposed design modifications and several high-temperature friction materials for use in aircraft disk brakes. The evaluation program was carried out on a specially built test apparatus utilizing a disk brake and wheel half from a small het aircraft. The apparatus enabled control of brake pressure, velocity, and braking time. Tests were run under both constant and variable velocity conditions and covered a kinetic energy range similar to that encountered in aircraft brake service. The results of the design evaluation program showed that some improvement in brake performance can be realized by making design changes in the components of the brake containing friction material. The materials evaluation showed that two friction materials show potential for use in aircraft disk brakes. One of the materials is a nickel-based sintered composite, while the other is a molybdenum-based material. Both materials show much lower wear rates than conventional copper-based materials and are better able to withstand the high temperatures encountered during braking. Additional materials improvement is necessary since both materials show a significant negative slope of the friction-velocity curve at low velocities.

  3. Evaluating heat rate modifications with the EPRI Plant Modification Operating Savings (PMOS) model

    SciTech Connect

    Fahd, G.; O`Connor, D.

    1997-03-01

    The Electric Power Research Institute (EPRI) developed the Plant Modification Operating Savings model (PMOS) to overcome the shortcomings of conventional planning tools in capturing the value of small-scale plant modifications. PMOS focuses on a single plant and, using readily available cost and performance data, determines the value of a modification at that plant to the system. PMOS provides decision-makers with accurate results to help select the projects with highest value to the system. It is a powerful, yet easy-to-use, computer model that is a useful addition to the utility planning toolkit. This paper discusses the PMOS use to evaluate plant heat rate modifications and describes the model`s methodology and applications.

  4. Modification and evaluation of fuel cell membranes

    NASA Astrophysics Data System (ADS)

    Nalawade, Amol Prataprao

    The primary goals of this study were modification of existing NafionRTM membranes and characterization of newly developed hydrocarbon-based membranes for high temperature fuel cell applications. Various NafionRTM/silicate nanocomposites were formulated via in situ sol-gel reactions for tetraethylorthosilicate. Different silicate composition profiles generated across membrane cross-sections were investigated by EDAX/ESEM. Composite water uptake, proton conductivity and fuel cell performance were comparable to that of unmodified Nafion RTM. Tafel analysis showed better electrode kinetics for composites having more silicate in the middle and less or no silicate at electrolyte-electrode interfaces. All composites showed reduced fuel cross-over and superior mechanical as well as chemical durability than unmodified NafionRTM. Poly(cyclohexadiene) (PCHD) materials were characterized in the interest of developing alternative low-cost proton exchange membranes. All cross-linked sulfonated (xsPCHD) membranes showed significantly higher water uptake at 80 °C and higher proton conductivity at 120 °C at all relative humidities (RH), compared to the current benchmark membrane, NafionRTM. A xsPCHD-poly(ethylene glycol) (PEG) copolymer and a xsPCHD-PEG blend surpassed the DOE target by exhibiting proton conductivities of 141.44 and 322.40 mS/cm, respectively, at 50 % RH. Although the PCHD-based PEMs exhibited thermal stability up to 150 °C, they showed poor mechanical properties which would cause poor membrane durability during fuel cell operation. Atomic force microscopy studies demonstrated nanophase separated morphology of xsPCHD having a higher degree of connectedness of hydrophilic domains in the copolymer and blends relative to the xsPCHD homopolymer. Broadband dielectric spectroscopy (BDS) was used to study sub-Tg relaxations in annealed poly(2,5-benzimidazole) (ABPBI) fuel cell precursor materials. A trend in degree of connectivity of charge migration pathways and

  5. The Evaluation of Litter Behavior Modification in a River Environment.

    ERIC Educational Resources Information Center

    Wagstaff, Mark C.; Wilson, Beth E.

    1988-01-01

    Behavior modification techniques were evaluated by observing litter collection behavior of commercial rafting groups. The number of litter pieces retrieved by treatment and control groups was significantly different. Results support the idea that verbal appeal and role modeling can be effective litter control techniques. (Author/CW)

  6. Silica aerogel threshold Cherenkov counters for the JLab Hall A spectrometers: improvements and proposed modifications

    SciTech Connect

    Luigi Lagamba; Evaristo Cisbani; S. Colilli; R. Crateri; R. De Leo; Salvatore Frullani; Franco Garibaldi; F. Giuliani; M. Gricia; Mauro Iodice; Riccardo Iommi; A. Leone; M. Lucentini; A. Mostarda; E. Nappi; Roberto Perrino; L. Pierangeli; F. Santavenere; Guido M. Urciuoli

    2001-10-01

    Recently approved experiments at Jefferson Lab Hall A require a clean kaon identification in a large electron, pion, and proton background environment. To this end, improved performance is required of the silica aerogel threshold Cherenkov counters installed in the focal plane of the two Hall A spectrometers. In this paper we propose two strategies to improve the performance of the Cherenkov counters which presently use a hydrophilic aerogel radiator, and convey Cherenkov photons towards the photomultipliers by means of mirrors with a parabolic shape in one direction and flat in the other. The first strategy is aerogel baking. In the second strategy we propose a modification of the counter geometry by replacing the mirrors with a planar diffusing surface and by displacing in a different way the photomultipliers. Tests at CERN with a 5GeV/c multiparticle beam revealed that both the strategies are able to increase significantly the number of the detected Cherenkov photons and, therefore, the detector performance.

  7. 77 FR 64126 - Notice of Proposed Withdrawal of Public Land for the Buffalo Bill Dam and Reservoir Modification...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... Bureau of Land Management Notice of Proposed Withdrawal of Public Land for the Buffalo Bill Dam and... recreational facilities constructed in connection with the Buffalo Bill Dam and Reservoir Modification Project... recreation site in the Buffalo Bill Dam and Reservoir Modification Project area: Sixth Principal Meridian T...

  8. Proposed modifications to the Lower Mokelumne River Project, California: FERC Project No. 2916-004. Final environmental impact statement

    SciTech Connect

    Not Available

    1993-11-01

    This final environmental impact statement (FEIS) has been prepared for the Federal Energy Regulatory Commission (Commission) to consider modifications to the existing Lower Mokelumne River Project (LMRP) (FERC Project No. 2916-004) in California. Chinook salmon and steelhead trout populations in the lower Mokelumne River have experienced recent declines and fish kills associated, in part, with discharges from Camanche Dam. The California Department of Fish and Game and the California Sportfishing Protection Alliance have asked the Commission to investigate and correct these problems. A wide range of different mitigation actions has been proposed by parties participating in the scoping of this proceeding, and staff has evaluated these proposed actions in this assessment. The staff is recommending a combination of flow and non-flow modifications to the existing license, including new minimum flow and minimum pool elevation requirements at Camanche Reservoir, ramping rates on dam releases, interim attraction and out-migrant spike flows, instream habitat improvements, and a series of studies and monitoring to determine feasible means for solving off-site fish passage problems.

  9. Environmental Assessment for the proposed modification and continued operation of the DIII-D facility

    SciTech Connect

    1995-07-01

    The EA evaluates the proposed action of modifying the DIII-D fusion facility and conducting related research activities at the GA San Diego site over 1995-1999 under DOE contract number DE-ACO3-89ER51114. The proposed action is need to advance magnetic fusion research for future generation fusion devices such as ITER and TPX. It was determined that the proposed action is not a major action significantly affecting the quality of the human environment according to NEPA; therefore a finding of no significant impact is made and an environmental impact statement is not required.

  10. A Proposed RTN Officer Performance Evaluation System

    DTIC Science & Technology

    1989-12-01

    studiod at the Naval Postpraduate School and practical theories relating to personnel management and performance evaluation. 4 The research method includes...various systems are discussed as the researcher perceives them. The fact that there is probably no agreed upon, fool-proof method of evaluating an...Performance Evaluation System. The research methodology Includes the following three componen: (1) a study of pertinent performance evaluation

  11. 75 FR 73983 - Proposed Modification of the Salt Lake City, UT, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Salt Lake City, UT, Class B... information from airspace users and others concerning a proposal to revise the Class B airspace area at Salt... Terminal, 397 North 2370 West, Salt Lake City, UT 84116. (3) The meeting on Thursday, February 3,...

  12. 76 FR 37034 - Proposed Modification of the Las Vegas, NV, Class B Airspace Area; Public Meetings; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Las Vegas, NV, Class B... of June 17, 2011, concerning a proposal to modify Class B airspace at Las Vegas, NV. The document... Gough, Manager, Airspace and Procedures, and Bill Ruggiero, Support Manager Las Vegas, TRACON,...

  13. A Proposal: Modification for Instruments and Tools Used in the Science Laboratory Setting for Students with Disabilities

    ERIC Educational Resources Information Center

    Kogan, Denis

    2015-01-01

    The purpose of this action research proposal is to create a Modification of Instruments and Tools in Science (MITS) program to address the need for providing Students With Disabilities (SWDs) appropriate access to scientific tools and techniques of scientific inquiry. This proposal contains a review of literature on SWDs, differentiating…

  14. 48 CFR 315.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... acquisitions that do not require preparation of an AP, based on the complexity of the acquisition and the role... years before assuming their designated role. This training requirement applies to evaluators performing... evaluations. However, this training requirement does not apply to peer review panel members. (B) Role of the...

  15. 48 CFR 315.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... adequately reflect the written technical report comments. (D) Conflict of interest. (1) If a panel member has... requirement for a technical evaluation report in accordance with paragraph (a)(3)(vi) of this section. (5) The establishment of a date for receipt of the technical evaluation report. (iv) Convening the technical...

  16. Evaluation of polydimethylsiloxane modification methods for cell response.

    PubMed

    Pakstis, L M; Dunkers, J P; Zheng, A; Vorburger, T V; Quinn, T P; Cicerone, M T

    2010-02-01

    Many methods exist in the literature to modify surfaces with extracellular matrix (ECM) proteins prior to cell seeding. However, there are few studies that systematically characterize and compare surface properties and cell response results among modification methods that use different bonding mechanisms. In this work, we compare cell response and physical characterization results from fibronectin or laminin attached to polydimethylsiloxane (PDMS) elastomer surfaces by physical adsorption, chemisorption, and covalent attachment to determine the best method to modify a deformable surface. We evaluate modification methods based on completeness and uniformity of coverage, surface roughness, and hydrophilicity of attached ECM protein. Smooth muscle cell adhesion, proliferation, morphology, and phenotype were also evaluated. We found that chemisorption methods resulted in higher amounts of protein attachment than physical adsorption and covalent bonding of the ECM proteins. Cell response to protein-modified surfaces was similar with respect to cell adhesion, area, aspect ratio, and phenotype. When all the data are considered, the chemisorption methods, most notably silane_70, provide the best surface properties and highest cell proliferation. (c) 2009 Wiley Periodicals, Inc.

  17. A Proposal for Evaluating Cognition in Assertiveness

    ERIC Educational Resources Information Center

    Vagos, Paula; Pereira, Anabela

    2010-01-01

    This article presents the development process and initial psychometric features of an instrument for evaluating cognition in assertiveness. This is an essential social skill for adolescent development and seems to encompass emotional, behavioral, and cognitive aspects. The instrument was created by combining both empirical and theoretical methods…

  18. 48 CFR 252.236-7000 - Modification proposals-price breakdown.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-price breakdown. 252.236-7000 Section 252.236-7000 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.236-7000 Modification proposals—price breakdown. As prescribed in 236.570(a), use the following clause: Modification Proposals—Price Breakdown (DEC 1991) (a) The...

  19. A proposal for evaluating cognition in assertiveness.

    PubMed

    Vagos, Paula; Pereira, Anabela

    2010-09-01

    This article presents the development process and initial psychometric features of an instrument for evaluating cognition in assertiveness. This is an essential social skill for adolescent development and seems to encompass emotional, behavioral, and cognitive aspects. The instrument was created by combining both empirical and theoretical methods for item construction, aiming to evaluate the cognitive realm of assertiveness. A sample of 996 adolescent students was used to test for reliability and validity. Results indicate good psychometric properties. The instrument is composed of 4 subscales: Outer Emotional Support, Functional Personal Ability, Interpersonal Management, and Affective Personal Ability. The Assertive Interpersonal Schema Questionnaire may potentially be a useful tool in the diagnosis of, understanding of, and development of a treatment plan for individuals with persistent difficulties in social events.

  20. 78 FR 47010 - Proposed Safety Evaluation for Plant-Specific

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... COMMISSION Proposed Safety Evaluation for Plant-Specific Technical Specifications Task Force Traveler... requesting public comment on the proposed model safety evaluation (SE) for plant- specific adoption of... ADAMS Accession Number ML13053A075. The proposed model SE for plant-specific adoption of TSTF-523...

  1. A framework for evaluating proposals for scientific activities in wilderness

    Treesearch

    Peter Landres

    2000-01-01

    This paper presents a structured framework for evaluating proposals for scientific activities in wilderness. Wilderness managers receive proposals for scientific activities ranging from unobtrusive inventorying of plants and animals to the use of chainsaws and helicopters for collecting information. Currently, there is no consistent process for evaluating proposals,...

  2. 78 FR 5761 - Proposed Modification of Significant New Uses of Ethaneperoxoic Acid, 1,1-Dimethylpropyl Ester

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... AGENCY 40 CFR Part 721 RIN 2070-AB27 Proposed Modification of Significant New Uses of Ethaneperoxoic Acid... rule (SNUR) for the chemical substance identified as ethaneperoxoic acid, 1,1-dimethylpropyl ester..., process, or use the chemical substance identified as ethaneperoxoic acid, 1,1-dimethylpropyl ester (PMN P...

  3. 76 FR 40293 - Proposed Amendment of Class D and Modification of Class E Airspace; Grand Junction, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... submitted in triplicate to the Docket Management System (see ADDRESSES section for address and phone number... September 15, 2010, which is incorporated by reference in 14 CFR 71.1. The Class D and Class E airspace... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class D and Modification of Class...

  4. 76 FR 28242 - Notice of Lodging of Proposed Modification to Consent Decree Under the Resource Conservation and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-16

    ... of Lodging of Proposed Modification to Consent Decree Under the Resource Conservation and Recovery..., Environment and Natural Resources Division, and either e-mailed to pubcomment-ees.enrd@usdoj.gov or mailed to... Section Chief, Environmental Enforcement Section, Environment and Natural Resources Division. BILLING...

  5. 77 FR 53907 - Notice of Proposed Withdrawal Modification and Transfer of Administrative Jurisdiction; Montana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ...-0940. FOR FURTHER INFORMATION CONTACT: Pam Wall, BLM, Miles City Field Office, 111 Garryowen Road.... Water will not be needed to fulfill the purpose of the withdrawal modification and transfer...

  6. 78 FR 78303 - Proposed Modification of Area Navigation (RNAV) Route T-265, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ... be submitted in triplicate to the Docket Management Facility (see ADDRESSES section for address and... frequency changes between the two facilities. This modification would shorten T- 265 by almost two nautical...

  7. Effects of proposed highway embankment modifications on water-surface elevations in the lower Pearl River flood plain near Slidell, Louisiana

    USGS Publications Warehouse

    Gilbert, J.J.; Schuck-Kolben, R. E.

    1987-01-01

    Major flooding in the lower Pearl River basin in recent years has caused extensive damage to homes and highways in the area. In 1980 and 1983, Interstate Highway 10 and U.S. Highway 190 were overtopped. In 1983, the Interstate Highway 10 crossing was seriously damaged by the flood. The U.S. Geological Survey, in cooperation with the Louisiana Department of Transportation and Development, Office of Highways, used a two-dimensional finite-element surface-water flow model to evaluate the effects the proposed embankment modifications at Interstate Highway 10 and U.S. Highway 90 on the water-surface elevations in the lower Pearl River flood plain near Slidell, Louisiana. The proposed modifications that were considered for the 1983 flood are: (1) Removal of all highway embankments, the natural condition, (2) extension of the West Pearl River bridge by 1,000 feet at U.S. Highway 90, (3) construction of a new 250-foot bridge opening in the U.S. Highways 190 and 90, west of the intersection of the highways. The proposed highway bridge modifications also incorporated lowering of ground-surface elevations under the new bridges to sea level. The modification that provided the largest reduction in backwater, about 35 percent, was a new bridge in Interstate Highway 10. The modification of the West Pearl River bridge at U.S. Highway 90 and replacement of the bridge in U.S. Highway 190 provide about a 25% reduction in backwater each. For the other modification conditions that required structural modifications, maximum backwater computed on the west side of the flood plain ranges from 0.0 to 0.8 foot and on the east side from 0.0 to 0.6 foot. Results show that although backwater is greater on the west side of the flood plain than on the east side, upstream of highway embankments, backwater decreases more rapidly in the upstream direction on the west side of the flood plain than on the east side. Analysis of the proposed modifications indicates that backwater would still occur on

  8. Discovering Cooperative Relationships of Chromatin Modifications in Human T Cells Based on a Proposed Closeness Measure

    PubMed Central

    Liu, Hongbo; Wu, Xueting; Zhu, Jiang; Su, Jianzhong; Wang, Fang; Cui, Ying; Zhang, Yan

    2010-01-01

    Background Eukaryotic transcription is accompanied by combinatorial chromatin modifications that serve as functional epigenetic markers. Composition of chromatin modifications specifies histone codes that regulate the associated gene. Discovering novel chromatin regulatory relationships are of general interest. Methodology/Principal Findings Based on the premise that the interaction of chromatin modifications is hypothesized to influence CpG methylation, we present a closeness measure to characterize the regulatory interactions of epigenomic features. The closeness measure is applied to genome-wide CpG methylation and histone modification datasets in human CD4+T cells to select a subset of potential features. To uncover epigenomic and genomic patterns, CpG loci are clustered into nine modules associated with distinct chromatin and genomic signatures based on terms of biological function. We then performed Bayesian network inference to uncover inherent regulatory relationships from the feature selected closeness measure profile and all nine module-specific profiles respectively. The global and module-specific network exhibits topological proximity and modularity. We found that the regulatory patterns of chromatin modifications differ significantly across modules and that distinct patterns are related to specific transcriptional levels and biological function. DNA methylation and genomic features are found to have little regulatory function. The regulatory relationships were partly validated by literature reviews. We also used partial correlation analysis in other cells to verify novel regulatory relationships. Conclusions/Significance The interactions among chromatin modifications and genomic elements characterized by a closeness measure help elucidate cooperative patterns of chromatin modification in transcriptional regulation and help decipher complex histone codes. PMID:21151929

  9. Evaluation of milk powder quality by protein oxidative modifications.

    PubMed

    Scheidegger, Dana; Radici, Paola M; Vergara-Roig, Víctor A; Bosio, Noelia S; Pesce, Silvia F; Pecora, Rolando P; Romano, José C P; Kivatinitz, Silvia C

    2013-06-01

    The objective of the present research was to evaluate commercially available milk powders according to their protein oxidative modifications and antioxidant capacity, and to evaluate if these characteristics are related to physical quality parameters such as dispersibility or stability during storage. Fifteen commercially processed spray-dried milk powders were evaluated: 6 whole milk powders (WMP), 4 skim milk powders (SMP), and 5 infant formula powders (IFP). Protein oxidative status was measured as protein carbonyl (PC) content, dityrosine content, and extent of protein polymerization. The level of PC was slightly lower in SMP than in WMP, whereas IFP had more than twice as much PC as WMP (2.8 ± 0.4, 2.1 ± 0.2, and 6.5 ± 1.3 nmol/mg of protein for WMP, SMP, and IFP, respectively). No differences were detected in dityrosine accumulation. Although all the possible pairs of parameters were tested for correlations, we found that 4 parameters were linked: PC, whey content, protein aggregate level, and dispersibility. After 9 mo of storage at -20°C or room temperature, all milk samples were analyzed to evaluate changes in protein oxidative status (PC, dityrosine, and protein integrity) and related parameters. Compared with the initial condition, PC increased in all tested samples after 9 mo of storage at -20°C or at room temperature. Stored milk powders had increased PC and decreased dispersibility compared with prestorage levels. Our results highlight the importance of protein oxidative status in milk powder and its relationship to other related quality parameters, such as protein integrity and dispersibility. Our findings suggest that the understanding of such relationships could help in developing quality differentiation for different types of milk powders in the product market.

  10. Evaluation criteria for commercially oriented materials processing in space proposals

    NASA Technical Reports Server (NTRS)

    Moore, W. F.; Mcdowell, J. R.

    1979-01-01

    An approach and criteria for evaluating NASA funded experiments and demonstrations which have commercial potential were developed. Methods for insuring quick initial screening of commercial proposals are presented. Recommendations are given for modifying the current evaluation approach. New criteria for evaluating commercially orientated materials processing in space (MPS) proposals are introduced. The process for selection of qualified individuals to evaluate the phases of this approach and criteria is considered and guidelines are set for its implementation.

  11. 76 FR 59420 - Proposed Information Collection; Alaska Guide Service Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... Fish and Wildlife Service Proposed Information Collection; Alaska Guide Service Evaluation AGENCY: Fish... Service Evaluation) to help us evaluate commercial guide services on our national wildlife refuges in the... method for monitoring permitted commercial guide activities. A regular program of client evaluation helps...

  12. A Review of The Society for Assisted Reproductive Technology Embryo Grading System and Proposed Modification

    PubMed Central

    Hossain, Amjad; Phelps, John; Agarwal, Ashok; Sanz, Eduardo; Mahadevan, Maha

    2016-01-01

    The Society for Assisted Reproductive Technology (SART) method of embryo grad- ing is unique, simple, and widely practiced, and its use has been mandatory for SART membership programs since 2010. Developed by SART in 2006, the current embryo grading system categories, “good, fair, and poor,” are limited because they do not describe the best 1-2 embryos in the interest of keeping pace with the shift in clinical practice to be more selective and to transfer fewer embryos. This inspired us to conduct a review on the SART embryo grading system. In this retrospective study, the literature on evaluation of human embryo quality in gen- eral, and the SART method of evaluation in particular, were reviewed for the period of 2000 to 2014. A multifaceted search pertaining to methods of embryo grading and trans- fer using a combination of relevant terms [embryo, mammalian, embryo transfer, grade, grading, morphology, biomarkers, SART, and in vitro fertilization (IVF)] was performed. The inclusion and exclusion in this review were dictated by the aim and scope of the study. Two investigators independently assessed the studies and extracted information. A total of 61 articles were reviewed. Very few studies have evaluated the efficacy of the SART embryo grading method. The present study suggests the necessity for revision of the current SART grading system. The system, as it is now, lacks criteria for describing the cohort specific best embryo and thus is of limited use in single embryo transfer. The study foresees heightened descriptive efficiency of the SART system by implementing the proposed changes. Strengths and weaknesses of the SART embryo grading were identified. Ideas for selecting the best cohort-specific embryo have been discussed, which may trigger methodological improvement in SART and other embryo grading systems. PMID:27441045

  13. A framework to evaluate proposals for scientific activities in wilderness

    Treesearch

    Peter Landres

    2010-01-01

    Every year, the four Federal wilderness management agencies - U.S. DOI Bureau of Land Management, Fish and Wildlife Service, National Park Service, and the USDA Forest Service - receive hundreds of proposals to conduct scientific studies within wilderness. There is no consistent and comprehensive framework for evaluating such proposals that accounts for the unique...

  14. 48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Confidentiality of... Receipt of Proposals and Information 1415.207-71 Confidentiality of proposal evaluation. (a) The... unauthorized disclosure of information. At this meeting each member and advisor shall sign a Confidentiality...

  15. Evaluation of Proposed Cab Glass Coating for FAA Control Towers

    DTIC Science & Technology

    2013-12-01

    wear vision correction? None Contacts Glasses Both If required, which correction do you use: Monofocal Bifocal Trifocal Color perception results...i AFRL-RH-WP-TR-2013-0123 Evaluation of Proposed Cab Glass Coating for FAA Control Towers Eric E. Geiselman Alan R. Pinkus, Ph.D...COVERED (From - To) 30-12-2013 Final Jun 2012 – Jun 2013 4. TITLE AND SUBTITLE Evaluation of Proposed Cab Glass Coating for FAA Control

  16. 77 FR 5429 - Proposed Modification of the Atlanta Class B Airspace Area; GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... Proposed Rulemaking Distribution System, which describes the application procedure. Background The primary... tailored to fit the operational needs of the primary airport. Atlanta's airspace system could not be set up... proposed ``wings'' in the four quadrants ] should be retained because eliminating the wings exposes...

  17. 78 FR 33772 - Proposed Modification of Class E Airspace; Brigham City, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... action on the proposed rule. The proposal contained in this action may be changed in light of comments.../airports_airtraffic/air_traffic/publications/airspace_amendments/ . You may review the public docket... hours at the Northwest Mountain Regional Office of the Federal Aviation Administration, Air Traffic...

  18. 78 FR 76779 - Proposed Modification of the Philadelphia, PA, Class B Airspace Area

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...This action proposes to amend the description of Area G of the Philadelphia Class B airspace area to correct a design error that resulted in the Class B airspace being published 2.1 nautical miles (NM) larger on the southeast side of the area than intended. No other changes to the Philadelphia Class B airspace are being proposed.

  19. 77 FR 27149 - Proposed Modification of Class E Airspace; Unalakleet, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... aircraft using a new Area Navigation (RNAV) Global Positioning System (GPS) standard instrument approach... be submitted in triplicate to the Docket Management System (see ADDRESSES section for address and... Proposed Rulemaking Distribution System, which describes the application procedure. The Proposal The FAA...

  20. 75 FR 60352 - Proposed Modification of the Seattle, WA, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... triplicate, to: Clark Desing, Manager, Operations Support Group, AJV-W2, Western Service Center, Air Traffic... CONTACT: To obtain details including a graphic depiction regarding this proposal, please contact Everett...

  1. 77 FR 3415 - Proposed Modification, Revocation and Establishment of Air Traffic Service Routes; Windsor Locks...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... Advisory Circular No. 11-2A, Notice of Proposed Rulemaking Distribution System, which describes the... for taxiway expansion and cargo and industry development in the quadrant where the VORTAC is currently...

  2. 75 FR 13049 - Proposed Modification of Class B Airspace; Charlotte, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ... (NPRM); correction. SUMMARY: This action provides the graphic chart for the proposed rule published in... first column, add the attached graphic chart before the Issue Date line. ] TP18MR10.004 Issued in...

  3. 48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... committee appointed to evaluate proposals shall discuss or disclose any information on the number, identity... brief all members and advisors on the sensitivity of the evaluation process and the prohibition against unauthorized disclosure of information. At this meeting each member and advisor shall sign a Confidentiality...

  4. 48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... committee appointed to evaluate proposals shall discuss or disclose any information on the number, identity... brief all members and advisors on the sensitivity of the evaluation process and the prohibition against unauthorized disclosure of information. At this meeting each member and advisor shall sign a Confidentiality...

  5. 48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... committee appointed to evaluate proposals shall discuss or disclose any information on the number, identity... brief all members and advisors on the sensitivity of the evaluation process and the prohibition against unauthorized disclosure of information. At this meeting each member and advisor shall sign a Confidentiality...

  6. 48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... committee appointed to evaluate proposals shall discuss or disclose any information on the number, identity... brief all members and advisors on the sensitivity of the evaluation process and the prohibition against unauthorized disclosure of information. At this meeting each member and advisor shall sign a Confidentiality...

  7. Proposed modifications to AOAC 996.06, optimizing the determination of trans fatty acids: presentation of data.

    PubMed

    Rozema, Brent; Mitchell, Barbara; Winters, Doug; Kohn, Andrew; Sullivan, Darryl; Meinholz, Erin

    2008-01-01

    The increased focus on the accuracy of trans fatty acid data generated using current methodologies has resulted in research initiatives to optimize the quality of these assays. In this study, scientists combined the established methodology from AOAC 996.06 and the American Oil Chemists Society method Ce 1h-05, as well as other independent research. As a result, method modifications are proposed that could allow for a more accurate determination of trans fat than the current AOAC 996.06 method. Validation data from this study are presented. The authors encourage peer review and offer to facilitate a collaborative validation to update AOAC 996.06.

  8. 78 FR 5155 - Proposed Modification of Class E Airspace; Lakeview, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ..., Washington, on January 9, 2013. Rex MacLean, Acting Manager, Operations Support Group, Western Service Center... instrument approach procedures at Lakeview County Airport. The FAA is proposing this action to enhance the safety and management of aircraft operations at Lakeview County Airport. This would also correct the...

  9. 75 FR 41774 - Proposed Establishment and Modification of Class E Airspace; Deer Park, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ...; Deer Park, WA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking... airspace at Deer Park Airport, Deer Park, WA, to accommodate aircraft using the existing Area Navigation (RNAV) Global Positioning System (GPS) Standard Instrument Approach Procedures (SIAPs) at Deer...

  10. 76 FR 78180 - Proposed Modification of Class E Airspace; Douglas, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... Airspace Docket No. 11-AWP-17) and be submitted in triplicate to the Docket Management System (see... Advisory Circular No. 11-2A, Notice of Proposed Rulemaking Distribution System, which describes the... effective September 15, 2011, which is incorporated by reference in 14 CFR 71.1. The Class E...

  11. 78 FR 65241 - Proposed Modification of Class D and Class E Airspace; Kailua-Kona, HI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ... Airspace; Kailua- Kona, HI AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... Airport at Keahole, Kailua-Kona, HI. Controlled airspace is necessary to accommodate the Area Navigation... upward from 700 feet above the surface, at Kona International Airport at Keahole, Kailua-Kona, HI. The...

  12. 78 FR 76781 - Proposed Modification of Class B Airspace; Salt Lake City, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...; Salt Lake City, UT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... Lake City Class B airspace area by raising the floor of a small portion of Class B airspace between the Salt Lake City Class B surface area and the Hill Air Force Base (AFB) Class D airspace area. This...

  13. 76 FR 46678 - Tris carbamoyl triazine; Proposed Modification of Significant New Uses

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... that exceed 40 parts per billion (ppb) in surface waters. The proposed SNUR for this chemical substance... substance in surface waters. Based on the results of the submitted fish and daphnid tests, fish were... surface waters and determined that the new COC would not be exceeded under expected conditions...

  14. 77 FR 5733 - Proposed Modification of Area Navigation (RNAV) Route Q-62; Northeast United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-06

    ... Terminal Arrival Routes (STARs) serving the Chicago O'Hare International Airport, IL, terminal area with... terminal area airspace phase of flight. DATES: Comments must be received on or before March 22, 2012... area into the Chicago O'Hare International Airport, IL, terminal area. This proposed route...

  15. 76 FR 56356 - Proposed Modification of Class E Airspace; Driggs, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ...: This action proposes to modify Class E airspace at Driggs-Reed Memorial Airport, Driggs, ID. Controlled...) standard instrument approach procedures at Driggs-Reed Memorial Airport, Driggs, ID. This action also would...-Reed Memorial Airport, Driggs, ID. DATES: Comments must be received on or before October 28, 2011...

  16. Dopamine Surface Modification of Trititanate Nanotubes: Proposed In-Situ Structure Models.

    PubMed

    Liu, Ruochen; Fu, Xuejian; Wang, Congyi; Dawson, Graham

    2016-04-18

    Two models for self-assembled dopamine on the surface of trititanate nanotubes are proposed: individual monomer units linked by π-π stacking of the aromatic regions and mono-attached units interacting through hydrogen bonds. This was investigated with solid state NMR spectroscopy studies and powder X-ray diffraction.

  17. 75 FR 10818 - Proposed Modifications to the Harmonized Tariff Schedule of the United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... Harmonized Commodity Description and Coding System (Harmonized System), and the Protocol thereto, are recommended by ] the World Customs Organization (WCO) (formerly known as the Customs Cooperation Council) for... Harmonized System. The report will also include appropriate explanatory information on the proposed...

  18. 77 FR 24159 - Proposed Modification of Class E Airspace; Plentywood, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-23

    ...: This action proposes to modify Class E airspace at Plentywood Sher-Wood Airport, Plentywood, MT... System (GPS) standard instrument approach procedures at Plentywood Sher-Wood Airport. The FAA is... Plentywood Sher-Wood Airport, Plentywood, MT. Controlled airspace is necessary to accommodate aircraft...

  19. Evaluation of optimum profile modification curves of profile shifted spur gears based on vibration responses

    NASA Astrophysics Data System (ADS)

    Ma, Hui; Pang, Xu; Feng, Ranjiao; Wen, Bangchun

    2016-03-01

    In this paper, a mesh stiffness model is developed for profile shifted gears with addendum modifications and tooth profile modifications (TPMs). The time-varying mesh stiffness (TVMS), load sharing factor (LSF), loaded static transmission error (LSTE) and non-loaded static transmission error (NLSTE) of a profile shifted spur gear pair with TPMs are obtained by the analytical model. The optimum profile modification curve under different amounts of TPM is determined by analyzing the LSTE first. Then, considering the effect of NLSTE, finite element (FE) model of a geared rotor system is established. The system vibration responses under different TPM curves are analyzed and the optimum modification curve is further evaluated by amplitude frequency responses. The results show that the optimum modification curve is related to the amount of TPM and modification coefficients. The comparison of the optimum profile modification curves is evaluated by LSTE and vibration responses, which shows that the optimum modification curve should be determined by evaluating the vibration response of the geared rotor system in the low mesh frequency range.

  20. Assessment of facial form modifications in orthodontics: proposal of a modified computerized mesh diagram analysis.

    PubMed

    Ferrario, V F; Sforza, C; Dalloca, L L; DeFranco, D J

    1996-03-01

    A modified computerized mesh diagram analysis enables rapid, easy, and independent quantifications of facial size, shape, and head position. A lateral cephalometric radiograph is traced, positioned in natural head position (NHP) according to the NHP registered on a lateral photograph, and superimposed by the standard grid of rectangles determined by the patient's upper face height and face depth. The patient's tracing is compared with a reference tracing of a norm. The two tracings are registered at nasion in NHP, and the size difference of the patient's mesh rectangles from the norm is quantified by a size normalization. The shape discrepancies are evaluated by calculating relevant displacement vectors for each cephalometric landmark, and a global difference factor. This computerized method provides a rapid graphic evaluation of the patient's sagittal and vertical discrepancies and can also be applied to determine the effects of orthodontic therapy and/or growth on the skeletal and dental relationships in a single patient.

  1. [Proposal for the modification of metformin use in patients with chronic kidney disease].

    PubMed

    Balogh, Zoltán; Mátyus, János

    2012-09-30

    Metformin is the first-line, widely used oral antidiabetic agent for the management of type 2 diabetes. There is increasing evidence that metformin use results in a reduction in cardiovascular morbidity and mortality, and might have anticancer activity. An extremely rare, but potentially life-threatening adverse effect of metformin is lactic acidosis, therefore, its use is traditionally contraindicated if the glomerular filtrate rate is below 60 mL/min. However, lactic acidosis is always associated with acute events, such as hypovolemia, acute cardiorespiratory illness, severe sepsis and acute renal or hepatic failure. Furthermore, administration of insulins and conventional antihyperglycemic agents increases the risk of severe hypoglycemic events when renal function is reduced. Therefore, the magnitude of the benefit of metformin use would outweigh potential risk of lactic acidosis in moderate chronic renal disease. After reviewing the literature, the authors give a proposal for the administration of metformin, according to the calculated glomerular filtrate rate.

  2. The RFP Challenge: Evaluation of Responses to Requests for Proposals.

    ERIC Educational Resources Information Center

    LeDuc, A. L.

    1993-01-01

    When a college contracts for a product or service, the request for proposal (RFP) may be an appropriate tool. It must clearly define what is needed for fair evaluation. A rating or weighting system for costs and benefits is useful for isolating and quantifying important elements of the decision-making process. (MSE)

  3. Computer evaluation of existing and proposed fire lookouts

    Treesearch

    Romain M. Mees

    1976-01-01

    A computer simulation model has been developed for evaluating the fire detection capabilities of existing and proposed lookout stations. The model uses coordinate location of fires and lookouts, tower elevation, and topographic data to judge location of stations, and to determine where a fire can be seen. The model was tested by comparing it with manual detection on a...

  4. EPA and California Air Resources Board disapprove Volkswagen’s Proposed Emissions Modification for model year 2012 – 2014 manual transmission diesel Passat vehicles

    EPA Pesticide Factsheets

    EPA and CARB approve an emissions modification proposed by Volkswagen (VW) to reduce nitrogen oxides emissions from model year 2009-2014, generation 1, 2.0 liter diesel Jetta, Golf, Beetle, and Audi A3 vehicles.

  5. Validation and modification of a proposed substaging system for patients with intermediate hepatocellular carcinoma.

    PubMed

    Wang, Jing-Houng; Kee, Kwong-Ming; Lin, Chih-Yun; Hung, Chao-Hung; Chen, Chien-Hung; Lee, Chuan-Mo; Lu, Sheng-Nan

    2015-02-01

    Based on up-to-seven criteria and Child-Pugh score, four substages of Barcelona Clinic Liver Cancer (BCLC) intermediate hepatocellular carcinoma (HCC) were proposed. The purpose of this study was to validate and modify this proposal. Between January 2002 and February 2011, newly diagnosed intermediate HCC patients underwent transarterial embolization (TAE) were enrolled. Patients were stratified into four (B1-B4) substages and followed up until death or end of 2012. Patients' survivals and discriminatory ability of substaging systems were compared. Five-hundred and eighty patients were enrolled. There were 56.6%, 33.8%, 7.4%, and 2.2% in substage B1, B2, B3, and B4. The 5-year survival rate was 21.4%, 13.9%, 7.4%, and 7.7% with median survival time of 2.4, 1.3, 0.5, and 0.8 years (P < 0.001). In addition to substage B1-B4, α-fetoprotein (AFP) level was an independent factor associated with survival in multivariate analysis. According to AFP < or > 200 ng/mL, B1 was classified into B1a and B1b, and B2 into B2a and B2b. There were no differences in survivals between B1b and B2a (P = 0.174), and B2b and B3 (P = 0.785). Patients were re-classified into modified (m)B1 (B1a), mB2 (B1b + B2a), mB3 (B2b + B3). The modified substages (mB1-mB3) showed a more desirable substaging system. For BCLC intermediate HCC patients, substages B1-B4 were useful in predicting survival after TAE. However, modified substaging system provided better prognostic prediction. © 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

  6. Proposed modification to the inhalable aerosol convention applicable to realistic workplace wind speeds.

    PubMed

    Sleeth, Darrah K; Vincent, James H

    2011-06-01

    The current convention for sampling inhalable aerosols was based on several mannequin studies performed in wind tunnels at wind speeds between 0.5 and 4 m s(-1). In reality, as we now know, the wind speed in most modern indoor working environments is generally at or below ∼0.2 m s(-1). Inhalability studies performed in calm air aerosol chambers have shown that human aspiration efficiency at essentially zero wind speed is not consistent with the existing inhalable aerosol convention, calling into question the universal applicability of the current standard. More recently, experiments were carried out in a new hybrid wind tunnel-calm air chamber at more representative workplace wind speeds, between ∼0.1 and 0.5 m s(-1), to fill in this knowledge gap. Comparing these new data to both the existing inhalable aerosol convention and a recently proposed alternative for low wind movement suggests that, while the existing inhalable aerosol convention remains appropriate for wind speeds above ∼0.2 m s(-1), the modified version is more appropriate for the range below ∼0.2 m s(-1).

  7. UH-60 Black Hawk engineering simulation model validation and proposed modifications

    NASA Technical Reports Server (NTRS)

    Kaplita, Thaddeus T.

    1986-01-01

    The engineering simulation model of the UH-60A Black Hawk was validated using comparisons of model time histories with flight test data and updated to improve the fidelity of the model. The flight test data, acquired by the Army Aviation Engineering Flight Activity and consisting of 90 time histories of transient responses to step and pulse control inputs and 16 sets of steady flight data, were processed and compared to corresponding model time histories and trim data by Sikorsky. The current UH-60A model was judged to provide an acceptably accurate simulation for use as an analytical tool, certain unsatisfactory areas were identified and potential approaches to produce a more representative simulation were evaluated.

  8. Proposed Modifications to Engineering Design Guidelines Related to Resistivity Measurements and Spacecraft Charging

    NASA Technical Reports Server (NTRS)

    Dennison, J. R.; Swaminathan, Prasanna; Jost, Randy; Brunson, Jerilyn; Green, Nelson; Frederickson, A. Robb

    2005-01-01

    A key parameter in modeling differential spacecraft charging is the resistivity of insulating materials. This determines how charge will accumulate and redistribute across the spacecraft, as well as the time scale for charge transport and dissipation. Existing spacecraft charging guidelines recommend use of tests and imported resistivity data from handbooks that are based principally upon ASTM methods that are more applicable to classical ground conditions and designed for problems associated with power loss through the dielectric, than for how long charge can be stored on an insulator. These data have been found to underestimate charging effects by one to four orders of magnitude for spacecraft charging applications. A review is presented of methods to measure the resistive of highly insulating materials, including the electrometer-resistance method, the electrometer-constant voltage method, the voltage rate-of-change method and the charge storage method. This is based on joint experimental studies conducted at NASA Jet Propulsion Laboratory and Utah State University to investigate the charge storage method and its relation to spacecraft charging. The different methods are found to be appropriate for different resistivity ranges and for different charging circumstances. A simple physics-based model of these methods allows separation of the polarization current and dark current components from long duration measurements of resistivity over day- to month-long time scales. Model parameters are directly related to the magnitude of charge transfer and storage and the rate of charge transport. The model largely explains the observed differences in resistivity found using the different methods and provides a framework for recommendations for the appropriate test method for spacecraft materials with different resistivities and applications. The proposed changes to the existing engineering guidelines are intended to provide design engineers more appropriate methods for

  9. H Scan/AHP advanced technology proposal evaluation process

    SciTech Connect

    Mack, S.; Valladares, M.R.S. de

    1996-10-01

    It is anticipated that a family of high value/impact projects will be funded by the Hydrogen Program to field test hydrogen technologies that are at advanced stages of development. These projects will add substantial value to the Program in several ways, by: demonstrating successful integration of multiple advanced technologies, providing critical insight on issues of larger scale equipment design, construction and operations management, yielding cost and performance data for competitive analysis, refining and deploying enhanced safety measures. These projects will be selected through a competitive proposal evaluation process. Because of the significant scope and funding levels of projects at these development phases, Program management has indicated the need for an augmented proposal evaluation strategy to ensure that supported projects are implemented by capable investigative teams and that their successful completion will optimally advance programmatic objectives. These objectives comprise a complex set of both quantitative and qualitative factors, many of which can only be estimated using expert judgment and opinion. To meet the above need, the National Renewable Energy Laboratory (NREL) and Energetics Inc. have jointly developed a proposal evaluation methodology called H Scan/AHP. The H Scan component of the process was developed by NREL. It is a two-part survey instrument that substantially augments the type and scope of information collected in a traditional proposal package. The AHP (Analytic Hierarchy Process) component was developed by Energetics. The AHP is an established decision support methodology that allows the Program decision makers to evaluate proposals relatively based on a unique set of weighted criteria that they have determined.

  10. The (neuro)cognitive mechanisms behind attention bias modification in anxiety: proposals based on theoretical accounts of attentional bias.

    PubMed

    Heeren, Alexandre; De Raedt, Rudi; Koster, Ernst H W; Philippot, Pierre

    2013-01-01

    Recently, researchers have investigated the causal nature of attentional bias for threat (AB) in the maintenance of anxiety disorders by experimentally manipulating it. They found that training anxious individuals to attend to non-threat stimuli reduces AB, which, in turn, reduces anxiety. This effect supports the hypothesis that AB can causally impact the maintenance of anxiety. At a fundamental level, however, uncertainty still abounds regarding the nature of the processes that mediate this effect. In the present paper, we propose that two contrasting approaches may be derived from theoretical accounts of AB. According to a first class of models, called the "valence-specific bias" models, modifying AB requires the modification of valence-specific attentional selectivity. According to a second class of models, called the "attention control models," modifying AB requires the modification of attention control, driven by the recruitment of the dorsolateral prefrontal cortex. We formulate a series of specific predictions, to provide suggestions to trial these two approaches one against the other. This knowledge is critical for understanding the mechanisms of AB in anxiety disorders, which bares important clinical implications.

  11. Evaluation and modification of CFB units at Slough Trading Estate

    SciTech Connect

    Vincent, R.Q.; Ballantyne, J.G.

    1997-12-31

    Slough Heat and Power (SHP), located just west of London, operates two circulating fluidized bed (CFB) combustion boilers (identified as FB1 and FB2) which assist in providing both power and steam to some 450 tenants located on the Slough Trading Estate. CFB technology was selected principally for (1) its fuel flexibility, (2) its ability to comply with government requirements on emissions and (3) its ability to fit the desired capacity units (with their relatively small footprint) into the limited space at the existing plant site. Construction of these units, each sized at 207,000 lb/hr at 1,260 psia and 948 F, began in 1989 with operation beginning in the latter part of 1991. Contract boiler acceptance tests were successfully passed in 1992. The units were originally intended to be operated on coal with gas and oil as back up fuels, depending on the economics. Government initiatives, designed to stimulate the development of non-fossil fueled power generation in the UK, catalyzed the owner`s interest in alternate fuels after the plant was built. Subsequently, the units have been co-fired with a blend of coal and densified refuse derived fuel (RDF) at up to a 50/50 heat input ratio. Early operation of these units was plagued by mechanical problems which affected the reliability and performance of the units. An independent assessment was made of the CFB units by FBT engineering Services to identify causes of operating, performance, and design shortcomings and to identify modifications that could be made to improve these areas. These problems have been associated with such areas of refractory, erosion, tubes and supports, clinkering and fouling, air distribution, and generally unstable unit performance. Because of the problems, the units have been operating only intermittently since commissioning. Based on the assessment of these problems, recommendations were made and design/operating changes implemented to correct these concerns and improve unit performance

  12. Emergy evaluation perspectives of a multipurpose dam proposal in Korea.

    PubMed

    Kang, Daeseok; Park, Seok Soon

    2002-11-01

    The 'emergy' concept was used to evaluate the economy of Korea and the contributions of a multipurpose dam proposal to the real wealth of the Korean economy. Emergy is defined as the available energy of one kind previously used up directly and indirectly to make a product or service. The indices for Korea calculated from the emergy evaluation were close to those of developed countries. Even though its monetary balance of payments was negative in 1997, the economy of Korea showed positive balance in trade when exports and imports were expressed in emergy. The emergy evaluation showed that the Korean economy places a large stress on its environment. Water supply and generation of electricity were the most important contributions of the proposed dam in terms of emergy; 46.5 and 45.1% of the total benefit, respectively. Flood control contributed 8.4% of the total benefit. Major costs associated with the proposed dam were from sediments (33.2% of the total cost), construction services (22.8%), and social disruption of the region (21.6%). In terms of emergy, the ratio of benefits to costs of the proposed dam was 2.78 if sediments are not included, and 1.86 if sediments are included, which result in more benefits than costs in both cases. The benefit to cost ratio of the dam was larger than that of the current system (1.42) without the dam whether sediments are included in the total cost or not. The environmental stress of the proposed dam was considerably lower than that of the Korean economy, but the dam might increase stress on local environment.

  13. Evaluation of dredged material proposed for ocean disposal from MOTBY

    SciTech Connect

    Barrows, E.S.; Mayhew, H.L.; Word, J.Q.

    1996-09-01

    The National Park Service, US Department of the Interior requested U.S. Army Corps of Engineers/New York District (USACE-NYD) to evaluate sediments around the Military Ocean Terminal (MOTBY) in Bayonne, New Jersey for unconfined ocean disposal at the Mud Dump Site. Sediment samples were collected from MOTBY. Tests and analyses were conducted on MOTBY sediment core samples. The evaluation of proposed dredged material from MOTBY included grain size and total organic carbon (TOC) analyses and one acute toxicity test with the amphipod Ampelisca abdita. In addition to this benthic toxicity test, a bioaccumulation test (28-day exposure) was conducted.

  14. A Proposed Resident's Operative Case Tracking and Evaluation System.

    PubMed

    Sehli, Deema N; Esene, Ignatius N; Baeesa, Saleh S

    2016-03-01

    Neurosurgery program trainers are continuously searching for new methods to evaluate trainees' competency besides number of cases and training duration. Recently, efforts are made on the development of reliable methods to teach competency and valid methods to measure teaching efficacy. Herein, we propose the "Resident's Operative Case Tracking and Evaluation System" (ROCTES) for the assessment and monitoring of the resident's performance quality during each procedure. We developed a data-based website and smartphone application for neurosurgical attending physicians, residents, and resident review committees in our accredited neurosurgical institutions. ROCTES runs through five steps: Login (Resident), Case Entry, Login (Attending Physician), Case Approval and Evaluation, and Report. The Resident enters each case record under "Case Entry" field and can "save," "edit," or "submit" the case data to the Attending Physician. The latter from the attending physician login profile will be able to "approve and evaluate" the resident's "knowledge," "skills," and "attitude" ranking from 1 to 15 for that particular case; add his comments and then "save," "edit," or "submit" the data, which can be viewed by users as a "report." Program Directors can also "login" to monitor the resident's progress. The implementation of this communication tool should enable the filtering and retrieval of information needed for the better assessment and monitoring of residents' exposure to variety of cases in each training center. This proposed evaluation system will provide a transparent assessment for residency training programs and should convert trainees into competent neurosurgeons. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Evaluation of microscopic hematuria: a critical review and proposed algorithm.

    PubMed

    Niemi, Matthew A; Cohen, Robert A

    2015-07-01

    Microscopic hematuria (MH), often discovered incidentally, has many causes, including benign processes, kidney disease, and genitourinary malignancy. The clinician, therefore, must decide how intensively to investigate the source of MH and select which tests to order and referrals to make, aiming not to overlook serious conditions while simultaneously avoiding unnecessary tests. Existing professional guidelines for the evaluation of MH are largely based on expert opinion and have weak evidence bases. Existing data demonstrate associations between isolated MH and various diseases in certain populations, and these associations serve as the basis for our proposed approach to the evaluation of MH. Various areas of ongoing uncertainty regarding the appropriate evaluation should be the basis for ongoing research.

  16. Rendezvous radar modification and evaluation. [for space shuttles

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The purpose of this effort was to continue the implementation and evaluation of the changes necessary to add the non-cooperative mode capability with frequency diversity and a doppler filter bank to the Apollo Rendezvous Radar while retaining the cooperative mode capability.

  17. [Evaluation of new and emerging health technologies. Proposal for classification].

    PubMed

    Prados-Torres, J D; Vidal-España, F; Barnestein-Fonseca, P; Gallo-García, C; Irastorza-Aldasoro, A; Leiva-Fernández, F

    2011-01-01

    Review and develop a proposal for the classification of health technologies (HT) evaluated by the Health Technology Assessment Agencies (HTAA). Peer review of AETS of the previous proposed classification of HT. Analysis of their input and suggestions for amendments. Construction of a new classification. Pilot study with physicians. Andalusian Public Health System. Spanish HTAA. Experts from HTAA. Tutors of family medicine residents. HT Update classification previously made by the research team. Peer review by Spanish HTAA. Qualitative and quantitative analysis of responses. Construction of a new and pilot study based on 12 evaluation reports of the HTAA. We obtained 11 thematic categories that are classified into 6 major head groups: 1, prevention technology; 2, diagnostic technology; 3, therapeutic technologies; 4, diagnostic and therapeutic technologies; 5, organizational technology, and 6, knowledge management and quality of care. In the pilot there was a good concordance in the classification of 8 of the 12 reports reviewed by physicians. Experts agree on 11 thematic categories of HT. A new classification of HT with double entry (Nature and purpose of HT) is proposed. APPLICABILITY: According to experts, the classification of the work of the HTAA may represent a useful tool to transfer and manage knowledge. Moreover, an adequate classification of the HTAA reports would help clinicians and other potential users to locate them and this can facilitate their dissemination. Copyright © 2010 SECA. Published by Elsevier Espana. All rights reserved.

  18. PRELIMINARY FIELD EVALUATION OF MERCURY CONTROL USING COMBUSTION MODIFICATIONS

    SciTech Connect

    Vitali Lissianski; Antonio Marquez

    2004-02-19

    In this project General Electric Energy and Environmental Research Corporation conducts a preliminary field evaluation of a novel technology, referred to as Hg/NO{sub x}, that can reduce emissions of both mercury (Hg) and oxides of nitrogen (NO{sub x}) from coal-fired power plants. The evaluation takes place in Green Station Unit 2 operated by Western Kentucky Energy. Reduction of Hg and NO{sub x} emissions in Unit 2 is achieved using coal reburning. Activities during first project year (January 23, 2003--January 22, 2004) included measurements of baseline Hg emissions in Unit 2 and pilot-scale testing. Baseline testing of Hg emissions in Green Unit 2 has been completed. Two fuels were tested with OFA system operating at minimum air flow. Mercury emissions were measured at ESP inlet and outlet, and at the stack using Ontario Hydro revised method. Testing demonstrated that baseline Hg reductions at ESP outlet and stack were 30-45% and 70-80%, respectively. Pilot-scale testing demonstrated good agreement with baseline measurements in Unit 2. Testing showed that fuel composition had an effect on the efficiency of Hg absorption on fly ash. Maximum achieved Hg removal in reburning was close to 90%. Maximum achieved Hg reduction at air staging conditions was 60%. Testing also demonstrated that lowering ESP temperature improved efficiency of Hg removal.

  19. Preliminary Field Evaluation of Mercury Control Using Combustion Modifications

    SciTech Connect

    V. Lissianski; P. Maly; T. Marquez

    2005-01-22

    In this project EER conducted a preliminary field evaluation of the integrated approach for mercury (Hg) and NO{sub x} control. The approach enhanced the 'naturally occurring' Hg capture by fly ash through combustion optimization, increasing carbon in ash content, and lowering ESP temperature. The evaluation took place in Green Station Units 1 and 2 located near Henderson, Kentucky and operated by Western Kentucky Energy. Units 1 and 2 are equipped with cold-side ESPs and wet scrubbers. Green Station Units 1 and 2 typically fire two types of fuel: a bituminous coal and a blend of bituminous coals based on availability. Testing of Hg emissions in Unit 2 without reburning system in operation and at minimum OFA demonstrated that efficiencies of Hg reduction downstream of the ESP were 30-40%. Testing also demonstrated that OFA system operation at 22% air resulted in 10% incremental increase in Hg removal efficiency at the ESP outlet. About 80% of Hg in flue gas at ESP outlet was present in the oxidized form. Testing of Hg emissions under reburning conditions showed that Hg emissions decreased with LOI increase and ESP temperature decrease. Testing demonstrated that maximum Hg reduction downstream of ESP was 40-45% at ESP temperatures higher than 300 F and 60-80% at ESP temperatures lower than 300 F. The program objective to demonstrate 80% Hg removal at the ESP outlet has been met.

  20. Motivational interviewing in dental hygiene education: curriculum modification and evaluation.

    PubMed

    Bray, Kimberly Krust; Catley, Delwyn; Voelker, Marsha A; Liston, Robin; Williams, Karen B

    2013-12-01

    Motivational interviewing (MI) is a person-centered, goal-directed method of communication for eliciting and strengthening intrinsic motivation for behavior change. Originally developed in the field of addiction therapy, MI has been increasing applied in the health professions with a growing body of successful outcomes for tobacco cessation and diabetic control, which can significantly impact oral health. MI has shown preliminary value for impacting oral behaviors that reduce early childhood caries, plaque, and gingival inflammation. While the training in and use of MI by oral health providers is emerging, full integration into dental and dental hygiene curricula has yet to be explored. Therefore, the purpose of this project was to evaluate the full implementation of MI in the classroom and clinic of a dental hygiene curriculum.

  1. Quality framework proposal for Component Material Evaluation (CME) projects.

    SciTech Connect

    Christensen, Naomi G.; Arfman, John F.; Limary, Siviengxay

    2008-09-01

    This report proposes the first stage of a Quality Framework approach that can be used to evaluate and document Component Material Evaluation (CME) projects. The first stage of the Quality Framework defines two tools that will be used to evaluate a CME project. The first tool is used to decompose a CME project into its essential elements. These elements can then be evaluated for inherent quality by looking at the subelements that impact their level of quality maturity or rigor. Quality Readiness Levels (QRLs) are used to valuate project elements for inherent quality. The Framework provides guidance for the Principal Investigator (PI) and stakeholders for CME project prerequisites that help to ensure the proper level of confidence in the deliverable given its intended use. The Framework also Provides a roadmap that defined when and how the Framework tools should be applied. Use of these tools allow the Principal Investigator (PI) and stakeholders to understand what elements the project will use to execute the project, the inherent quality of the elements, which of those are critical to the project and why, and the risks associated to the project's elements.

  2. RBME coral temperature reconstruction: An evaluation, modifications, and recommendations

    NASA Astrophysics Data System (ADS)

    Sinclair, Daniel J.

    2015-04-01

    Rayleigh-Based Multi-Element (RBME) coral temperature reconstruction (Gaetani et al., 2011) is an important new method potentially allowing accurate ocean temperatures to be reconstructed from aragonitic corals without the need for in-situ calibration. RBME is based on a mathematical model which assumes that trace element uptake into coral skeleton is mediated by (1) temperature-dependent (inorganic) partition coefficients, and (2) a temperature-dependent change in the proportion of ions in a calcifying fluid that are precipitated as CaCO3. A time-series of Sr, Mg and Ba measurements can therefore be formulated as a set of simultaneous equations allowing temperatures and model fit-parameters to be solved numerically by least-squares minimization. Here, I critically review the RBME method, focusing on assumptions underlying the mathematical model, implementation of the numerical scheme, and the accuracy of temperature reconstruction. The equations in the RBME are highly nonlinear, and their number scales with the length of the time-series. These 'high-dimensional nonlinear optimization' problems are characterized by high computational cost, and the difficulty in finding the true 'global' minimum rather than false 'local' minima. Tests show that several of the RBME equations are highly sensitive to changing parameters thereby making it difficult for minimization algorithms to search broadly in parameter space. The method is therefore exceedingly slow and has a very strong tendency to find local optima that are close to the initial guess (which must be supplied by the user) making it very prone to 'operator bias'. Here a new formulation of the RBME system is proposed that allows much faster optimization, and a much broader search of parameter space. Testing of the RBME method reveals a number of problems. Firstly, RBME can produce many solutions to a given set of Sr, Mg and Ba data that are nearly identical in their minimization function (i.e., are equally good) but

  3. Evaluation of Proteomic Search Engines for the Analysis of Histone Modifications

    PubMed Central

    2015-01-01

    Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118. PMID:25167464

  4. Evaluation of proteomic search engines for the analysis of histone modifications.

    PubMed

    Yuan, Zuo-Fei; Lin, Shu; Molden, Rosalynn C; Garcia, Benjamin A

    2014-10-03

    Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118.

  5. Modification and performance evaluation of a mono-valve engine

    NASA Astrophysics Data System (ADS)

    Behrens, Justin W.

    A four-stroke engine utilizing one tappet valve for both the intake and exhaust gas exchange processes has been built and evaluated. The engine operates under its own power, but has a reduced power capacity than the conventional 2-valve engine. The reduction in power is traced to higher than expected amounts of exhaust gases flowing back into the intake system. Design changes to the cylinder head will fix the back flow problems, but the future capacity of mono-valve engine technology cannot be estimated. The back flow of exhaust gases increases the exhaust gas recirculation (EGR) rate and deteriorates combustion. Intake pressure data shows the mono-valve engine requires an advanced intake valve closing (IVC) time to prevent back flow of charge air. A single actuation camshaft with advanced IVC was tested in the mono-valve engine, and was found to improve exhaust scavenging at TDC and nearly eliminated all charge air back flow at IVC. The optimum IVC timing is shown to be approximately 30 crank angle degrees after BDC. The mono-valve cylinder head utilizes a rotary valve positioned above the tappet valve. The open spaces inside the rotary valveand between the rotary valve and tappet valve represent a common volume that needs to be reduced in order to reduce the base EGR rate. Multiple rotary valve configurations were tested, and the size of the common volume was found to have no effect on back flow but a direct effect on the EGR rate and engine performance. The position of the rotary valve with respect to crank angle has a direct effect on the scavenging process. Optimum scavenging occurs when the intake port is opened just after TDC.

  6. 30 CFR 18.81 - Field modification of approved (permissible) equipment; application for approval of modification...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES... and Certification Center, 765 Technology Drive, Triadelphia, WV 26059. (b) Proposed modifications...

  7. 30 CFR 18.81 - Field modification of approved (permissible) equipment; application for approval of modification...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES... and Certification Center, 765 Technology Drive, Triadelphia, WV 26059. (b) Proposed modifications...

  8. Evaluation of materials proposed for use in space flight

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1981-01-01

    The primary irritancy and allergenicity of flame resistant treated cotton knit shirts proposed for use in space flight were evaluated. The knitted shirts were supplied by NASA as follows: knitted shirts with collars were made of two-ply mercerized single-knit cotton jersey. The fabric was treated with tetrakis (hydroxymethyl) phosphonium hydroxide and subsequently cured with gaseous ammonia (THPOH/NH3). The final treatment comprised adding on diammonium phosphate (DAP)/urea. The treated fabric was process scoured to remove extraneous materials, top softened and mechanically or chemically finished as required for specific needs. Diammonium phosphate is a more efficient flame inhabitant than the phosphonium; thus, the combination treatment served to impart higher resistance to ignition and sustained combustion as required by NASA test standard.

  9. Forensic medical evaluations of child maltreatment: a proposed research agenda.

    PubMed

    Dubowitz, Howard; Christian, Cindy W; Hymel, Kent; Kellogg, Nancy D

    2014-11-01

    Physicians play an important role in the forensic evaluation of suspected child abuse and neglect. There has been considerable progress in the medical field, helping distinguish findings related to maltreatment from other conditions or circumstances. Nevertheless, important questions remain. This article covers several of these questions and proposes a research agenda concerning five main topics: sexual abuse, neglect, fractures, abusive head trauma, and physicians work in interdisciplinary settings. The suggestions are hardly inclusive, but offer suggestions the authors think are priorities, and ones that research could reasonably address. By providing some background to gaps in our knowledge, this paper should be of interest to a broader audience than just medical professionals. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Evaluating a Proposed 20% National Renewable Portfolio Standard

    SciTech Connect

    Logan, J.; Sullivan, P.; Short, W.; Bird, L.; James, T. L.; Shah, M. R.

    2009-02-01

    This paper provides a preliminary analysis of the impacts of a proposed 20% national renewable portfolio standard (RPS) by 2021, which has been advanced in the U.S. Congress by Senator Jeff Bingaman of New Mexico. The paper was prepared before the America Recovery and Reinvestment Act was signed into law by President Barack Obama on February 17, 2009, and thus does not consider important changes in renewable energy (RE) policy that need to be addressed in follow-on analysis. We use NREL's Regional Energy Deployment System (ReEDS) model to evaluate the impacts of the RPS requirements on the energy sector and consider design issues associated with renewable energy certificate (REC) trading markets.

  11. Evaluating a Proposed 20% National Renewable Portfolio Standard

    SciTech Connect

    Logan, Jeffrey; Sullivan, Patrick; Short, Walter; Bird, Lori; James, Ted L.; Shah, Monisha R.

    2009-02-01

    This paper provides a preliminary analysis of the impacts of a proposed 20% national renewable portfolio standard (RPS) by 2021, which has been advanced in the U.S. Congress by Senator Jeff Bingaman of New Mexico. The paper was prepared before the America Recovery and Reinvestment Act was signed into law by President Barack Obama on February 17, 2009, and thus does not consider important changes in renewable energy (RE) policy that need to be addressed in follow-on analysis. We use NREL's Regional Energy Deployment System (ReEDS) model to evaluate the impacts of the RPS requirements on the energy sector and consider design issues associated with renewable energy certificate (REC) trading markets.

  12. Science Base and Tools for Evaluating Stream Restoration Project Proposals.

    NASA Astrophysics Data System (ADS)

    Cluer, B.; Thorne, C.; Skidmore, P.; Castro, J.; Pess, G.; Beechie, T.; Shea, C.

    2008-12-01

    Stream restoration, stabilization, or enhancement projects typically employ site-specific designs and site- scale habitat improvement projects have become the default solution to many habitat problems and constraints. Such projects are often planned and implemented without thorough consideration of the broader scale problems that may be contributing to habitat degradation, attention to project resiliency to flood events, accounting for possible changes in climate or watershed land use, or ensuring the long term sustainability of the project. To address these issues, NOAA Fisheries and USFWS have collaboratively commissioned research to develop a science document and accompanying tools to support more consistent and comprehensive review of stream management and restoration projects proposals by Service staff responsible for permitting. The science document synthesizes the body of knowledge in fluvial geomorphology and presents it in a way that is accessible to the Services staff biologists, who are not trained experts in this field. Accompanying the science document are two electronic tools: a Project Information Checklist to assist in evaluating whether a proposal includes all the information necessary to allow critical and thorough project evaluation; and a Project Evaluation Tool (in flow chart format) that guides reviewers through the steps necessary to critically evaluate the quality of the information submitted, the goals and objectives of the project, project planning and development, project design, geomorphic-habitat-species relevance, and risks to listed species. Materials for training Services staff and others in the efficient use of the science document and tools have also been developed. The longer term goals of this effort include: enabling consistent and comprehensive reviews that are completed in a timely fashion by regulators; facilitating improved project planning and design by proponents; encouraging projects that are attuned to their watershed

  13. Fiberoptic endoscopic evaluation of swallowing (FEES): proposal for informed consent

    PubMed Central

    Nacci, A; Ursino, F; La Vela, R; Matteucci, F; Mallardi, V; Fattori, B

    2008-01-01

    Summary Fiberoptic endoscopic evaluation of swallowing (FEES) is now a first choice method for studying swallowing disorders on account of the various advantages it offers: easy to use, very well tolerated, allows bedside examination and is economic. Nevertheless, this diagnostic procedure is not without risks, the most probable consequences of which include discomfort, gagging and/or vomiting, vasovagal syncope, epistaxis, mucosal perforation, adverse reactions to topical anaesthetics and laryngospasm. The risks involved with FEES stress the importance of informing the patient of these; this is an important aspect in medicine that necessarily and immediately implies receiving the patient’s so-called “informed consent”. Informed consent should be obtained not only by means of specific printed forms but also after the patient has had an interview with the physician who will be performing the procedure and who will offer information according to the personal clinical, psychological, cultural and linguistic situation of the patient and in keeping with the type of procedure proposed. In the case of FEES, as with other invasive or non-invasive diagnostic procedures, therefore, routine written and signed consent, together with a patient/physician interview should fulfil what is known as “complete information”. In this report, a specific form for informed consent to FEES procedures, is proposed. PMID:18939710

  14. Evaluating the potential effectiveness of proposed environmental justice initiatives

    SciTech Connect

    Greenfield, N.L.; Namovicz, C.R.

    1994-12-31

    Congress directed the US Environmental Protection Agency (EPA) to create the Technical Assistance Grant (TAG) program to address the concerns of these citizens and, thereby improve community relations at Superfund sites. TAGs provide funding to allow affected residents to hire independent scientific and technical consultants to help them understand the issues at the site and better participate in remedy selection. This study will not directly assess the experience of Environmental Justice sites within the Superfund program. Rather, this study examines existing data on TAGs and the applicability of an expanded TAG program in addressing expressed Environmental Justice concerns. Specifically, the study compares the characteristics of sites with TAGs to a matched control group of sites/communities without TAGs. The study establishes a rigorous statistical baseline upon which it can evaluate the marginal contribution of outreach initiatives to the needs and concerns of minority and low income communities. The results of these analyses will serve as a foundation for evaluating proposed changes in the scope and emphasis of Superfund`s community relations and Environmental Justice outreach programs.

  15. Development and evaluation of modifications to the Sickness Impact Profile for head injury.

    PubMed

    Temkin, N; McLean, A; Dikmen, S; Gale, J; Bergner, M; Almes, M J

    1988-01-01

    Three modifications were made to the Sickness Impact Profile, a behavior-based measure of health status, to improve its sensitivity to the effects of head injury. (1) Additional items were included to capture head injury sequelae and behaviors typical of young adults, the age group to which head injury most frequently occurs. (2) Subjects individually excluded behaviors irrelevant to them, thus allowing the score to better reflect injury-related changes. (3) The different areas of functioning on the Sickness Impact Profile were reweighted to reflect global judgments of the construct's contribution to overall functioning rather than the sum of the item contributions. Only the first modification is head-injury specific. The others, are relevant to any disease or injury. The performance of the modifications was evaluated in a longitudinal study of 102 head injured and 102 comparison subjects tested at 1 and 12 months after injury. The evaluation of the modifications was based on their ability to distinguish head injury from comparison subjects and on the strength of their relationship with measures of brain dysfunction. Despite a few statistically significant improvements in discrimination, differences of a practical degree were not obtained. The standard Sickness Impact Profile performed well and is recommended for evaluation of day-to-day functioning in head injury studies.

  16. 43 CFR 404.22 - How will Reclamation evaluate my full proposal?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false How will Reclamation evaluate my full... Reclamation evaluate my full proposal? (a) Reclamation will evaluate the full proposal to conduct an appraisal... is complete, Reclamation will evaluate your proposal against all other proposals received, using a...

  17. 78 FR 15739 - Notice of Lodging of Proposed Third Modification to Consent Decree Under the Clean Air Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... modification upon written request and payment of reproduction costs. Please mail your request and payment to... in the amount of $7.50 (25 cents per page reproduction cost) payable to the United States...

  18. 76 FR 27380 - Proposed Information Collection (Report of Medical Examination for Disability Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... AFFAIRS Proposed Information Collection (Report of Medical Examination for Disability Evaluation); Comment... opportunity for public comment on the proposed collection of certain information by the agency. Under the... Register concerning each proposed collection of information, including each proposed extension of...

  19. Evaluation of replacement protocols and modifications to TCP to enhance ASC Wide Area Network performance.

    SciTech Connect

    Romero, Randy L. Jr.

    2004-09-01

    Historically, TCP/IP has been the protocol suite used to transfer data throughout the Advanced Simulation and Computing (ASC) community. However, TCP was developed many years ago for an environment very different from the ASC Wide Area Network (WAN) of today. There have been numerous publications that hint of better performance if modifications were made to the TCP algorithms or a different protocol was used to transfer data across a high bandwidth, high delay WAN. Since Sandia National Laboratories wants to maximize the ASC WAN performance to support the Thor's Hammer supercomputer, there is strong interest in evaluating modifications to the TCP protocol and in evaluating alternatives to TCP, such as SCTP, to determine if they provide improved performance. Therefore, the goal of this project is to test, evaluate, compare, and report protocol technologies that enhance the performance of the ASC WAN.

  20. Physical evaluation system to determine medical risk and indicated dental therapy modifications.

    PubMed

    McCarthy, F M; Malamed, S F

    1979-08-01

    The physical evaluation system allows the practitioner to rapidly classify each patient according to medical risk and thus to provide dental treatment comfortably and safely. The evaluation system serves as a guide to the level of dental therapy, deisions of management, and modification of treatment for the medically compromised patient. Extensive use of the ADA physical status classification system in dentistry would allow meaningful studies of morbidity and mortality that are related to various management protocols and could conceivably have an impact on insurance schedules associated with psychosedation modalities and general anethesia on an out patient basis. A physical evaluation system cannot substitute for knowledge and good judgment. Recommended categories of physical status and modification of treatment should not be considered as absolutes, but as guides. Wheras the guidelines may appear to be inflexible, they should not be considered as such. Deviation from recommendations is often justified and is expected.

  1. Technical evaluation of proposed Ukrainian Central Radioactive Waste Processing Facility

    SciTech Connect

    Gates, R.; Glukhov, A.; Markowski, F.

    1996-06-01

    This technical report is a comprehensive evaluation of the proposal by the Ukrainian State Committee on Nuclear Power Utilization to create a central facility for radioactive waste (not spent fuel) processing. The central facility is intended to process liquid and solid radioactive wastes generated from all of the Ukrainian nuclear power plants and the waste generated as a result of Chernobyl 1, 2 and 3 decommissioning efforts. In addition, this report provides general information on the quantity and total activity of radioactive waste in the 30-km Zone and the Sarcophagus from the Chernobyl accident. Processing options are described that may ultimately be used in the long-term disposal of selected 30-km Zone and Sarcophagus wastes. A detailed report on the issues concerning the construction of a Ukrainian Central Radioactive Waste Processing Facility (CRWPF) from the Ukrainian Scientific Research and Design institute for Industrial Technology was obtained and incorporated into this report. This report outlines various processing options, their associated costs and construction schedules, which can be applied to solving the operating and decommissioning radioactive waste management problems in Ukraine. The costs and schedules are best estimates based upon the most current US industry practice and vendor information. This report focuses primarily on the handling and processing of what is defined in the US as low-level radioactive wastes.

  2. A proposal of method for evaluating airborne MWCNT concentration.

    PubMed

    Ono-Ogasawara, Mariko; Myojo, Toshihiko

    2011-01-01

    As multi-wall carbon nanotubes (MWCNTs) come to be used in a wider range of products, increasing production is expected to result in greater exposure of workers to MWCNTs. In this research, we present a method for evaluating the concentration of MWCNT aerosols distinctively on the basis of the elemental carbon (EC) concentration. Respirable dust is sampled using a Sioutas cascade impactor (SCI) for a certain volume of workplace air. The SCI can collect size-segregated particles having aerodynamic diameters of 2.5 μm, 1.0 μm, 0.5 μm, 0.25 μm and <0.25 μm. MWCNTs in sampled particles are determined by carbon analysis. Based on the phenomenon that MWCNTs easily aggregate/agglomerate, the present procedure for distinguishing MWCNTs uses the EC in particles larger than 1 μm as an index of MWCNT; the EC is oxidized at a high temperature, 920°C, in carbon analysis. We propose a three-step procedure for distinguishing between MWCNT aerosol and atmospheric particulate matter, and for measuring MWCNT concentrations in workplace air on the basis of EC concentration.

  3. 15 CFR 400.26 - Criteria for evaluation of applications for expansions, subzones or other modifications of zones.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Criteria for evaluation of applications for expansions, subzones or other modifications of zones. 400.26 Section 400.26 Commerce and... Authority § 400.26 Criteria for evaluation of applications for expansions, subzones or other modifications...

  4. 15 CFR 400.26 - Criteria for evaluation of applications for expansions, subzones or other modifications of zones.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Criteria for evaluation of applications for expansions, subzones or other modifications of zones. 400.26 Section 400.26 Commerce and... Authority § 400.26 Criteria for evaluation of applications for expansions, subzones or other modifications...

  5. Sustainable urban housing in Kathmandu, Nepal: Proposals and evaluations

    NASA Astrophysics Data System (ADS)

    Shrestha, Vikas

    quantifies the embodied energy of basic building materials that are used in Nepal; proposes new types of locally-produced insulation; and develops a sustainable design evaluation system based on LEED. This integrated system of sustainable materials database, evaluation system, and vernacular-based housing prototypes developed in this dissertation lays out an example for other third world countries.

  6. 76 FR 62813 - Pilot Program To Evaluate Proposed Proprietary Name Submissions; Public Meeting on Pilot Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... HUMAN SERVICES Food and Drug Administration Pilot Program To Evaluate Proposed Proprietary Name... participating pharmaceutical firms to evaluate proposed proprietary names and submit the data generated from... pharmaceutical firms to evaluate proposed proprietary names and submit the data generated from those evaluations...

  7. Evaluating Federal Water Projects: A Critique of Proposed Standards

    ERIC Educational Resources Information Center

    Cicchetti, Charles J.; And Others

    1973-01-01

    Questions the feasibility of, and validity of the concepts behind, some of the new procedures proposed by the Water Resources Council. Concludes that the proposed procedures, if accepted in their present form, will bias water resource management in favor of development and against the preservation of the natural environment. (JR)

  8. Evaluating Federal Water Projects: A Critique of Proposed Standards

    ERIC Educational Resources Information Center

    Cicchetti, Charles J.; And Others

    1973-01-01

    Questions the feasibility of, and validity of the concepts behind, some of the new procedures proposed by the Water Resources Council. Concludes that the proposed procedures, if accepted in their present form, will bias water resource management in favor of development and against the preservation of the natural environment. (JR)

  9. 77 FR 42462 - Hawaii State Plan for Occupational Safety and Health; Proposed Modification of 18(e) Plan Approval

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-19

    ... Administration (OSHA), Department of Labor. ACTION: Notice of opportunity to request informal public hearing... Relations has requested a temporary modification of the state plan's approval status from final approval to... Assistant Secretary during this proceeding. Members of the public may also submit requests for an...

  10. Proposed 237U Evaluation for the next ENDL Release

    SciTech Connect

    Brown, D; Summers, N; Thompson, I; Younes, W

    2007-11-07

    We detail the new LLNL evaluation of {sup 237}U for inclusion in both the next release of the ENDL and ENDF/B-VII databases. This evaluation is based on a combination of TALYS calculations, data fits and the earlier JEFF-3.1 evaluation. Our evaluation is in excellent agreement with published surrogate (n, f) data [11, 12, 13, 14, 18] and the unpublished LLNL surrogate (n,2n) data [16].

  11. Safety evaluation of a new proposed standard laboratory coat

    SciTech Connect

    Pane, A.J.

    1984-07-01

    A proposed disposable laboratory coat was destructively tested and compared to the present coat. Tests included flame, acids, bases, solvents, exploding glass, allergic reactions, dust penetration, and tensile properties. (ACR)

  12. Evaluation of gene modification strategies for the development of low-alcohol-wine yeasts.

    PubMed

    Varela, C; Kutyna, D R; Solomon, M R; Black, C A; Borneman, A; Henschke, P A; Pretorius, I S; Chambers, P J

    2012-09-01

    Saccharomyces cerevisiae has evolved a highly efficient strategy for energy generation which maximizes ATP energy production from sugar. This adaptation enables efficient energy generation under anaerobic conditions and limits competition from other microorganisms by producing toxic metabolites, such as ethanol and CO(2). Yeast fermentative and flavor capacity forms the biotechnological basis of a wide range of alcohol-containing beverages. Largely as a result of consumer demand for improved flavor, the alcohol content of some beverages like wine has increased. However, a global trend has recently emerged toward lowering the ethanol content of alcoholic beverages. One option for decreasing ethanol concentration is to use yeast strains able to divert some carbon away from ethanol production. In the case of wine, we have generated and evaluated a large number of gene modifications that were predicted, or known, to impact ethanol formation. Using the same yeast genetic background, 41 modifications were assessed. Enhancing glycerol production by increasing expression of the glyceraldehyde-3-phosphate dehydrogenase gene, GPD1, was the most efficient strategy to lower ethanol concentration. However, additional modifications were needed to avoid negatively affecting wine quality. Two strains carrying several stable, chromosomally integrated modifications showed significantly lower ethanol production in fermenting grape juice. Strain AWRI2531 was able to decrease ethanol concentrations from 15.6% (vol/vol) to 13.2% (vol/vol), whereas AWRI2532 lowered ethanol content from 15.6% (vol/vol) to 12% (vol/vol) in both Chardonnay and Cabernet Sauvignon juices. Both strains, however, produced high concentrations of acetaldehyde and acetoin, which negatively affect wine flavor. Further modifications of these strains allowed reduction of these metabolites.

  13. Evaluation of Gene Modification Strategies for the Development of Low-Alcohol-Wine Yeasts

    PubMed Central

    Kutyna, D. R.; Solomon, M. R.; Black, C. A.; Borneman, A.; Henschke, P. A.; Pretorius, I. S.; Chambers, P. J.

    2012-01-01

    Saccharomyces cerevisiae has evolved a highly efficient strategy for energy generation which maximizes ATP energy production from sugar. This adaptation enables efficient energy generation under anaerobic conditions and limits competition from other microorganisms by producing toxic metabolites, such as ethanol and CO2. Yeast fermentative and flavor capacity forms the biotechnological basis of a wide range of alcohol-containing beverages. Largely as a result of consumer demand for improved flavor, the alcohol content of some beverages like wine has increased. However, a global trend has recently emerged toward lowering the ethanol content of alcoholic beverages. One option for decreasing ethanol concentration is to use yeast strains able to divert some carbon away from ethanol production. In the case of wine, we have generated and evaluated a large number of gene modifications that were predicted, or known, to impact ethanol formation. Using the same yeast genetic background, 41 modifications were assessed. Enhancing glycerol production by increasing expression of the glyceraldehyde-3-phosphate dehydrogenase gene, GPD1, was the most efficient strategy to lower ethanol concentration. However, additional modifications were needed to avoid negatively affecting wine quality. Two strains carrying several stable, chromosomally integrated modifications showed significantly lower ethanol production in fermenting grape juice. Strain AWRI2531 was able to decrease ethanol concentrations from 15.6% (vol/vol) to 13.2% (vol/vol), whereas AWRI2532 lowered ethanol content from 15.6% (vol/vol) to 12% (vol/vol) in both Chardonnay and Cabernet Sauvignon juices. Both strains, however, produced high concentrations of acetaldehyde and acetoin, which negatively affect wine flavor. Further modifications of these strains allowed reduction of these metabolites. PMID:22729542

  14. Proposed modifications to the RCRA post-closure permit for the Bear Creek Hydrogeologic Regime at the US Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to several conditions of the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Bear Creek Hydrogeologic Regime (BCHR). These permit conditions define the requirements for RCRA post-closure corrective action groundwater monitoring at the S-3 Ponds, the Oil Landfarm, and the Bear Creek Burial Grounds (units A, C-West, and Walk-in Pits). Modification of these PCP conditions is requested to: (1) clarify the planned integration of RCRA post-closure corrective action groundwater monitoring with the monitoring program to be established in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Record of Decision (ROD) for the Bear Creek Valley (BCV) Watershed, (2) revise several of the current technical requirements for groundwater monitoring based on implementation of the RCRA post-closure corrective action monitoring program during 1996, and (3) update applicable technical procedures with revised versions recently issued by the Y-12 Plant Groundwater Protection Program (GWPP). With these modifications, the Y-12 Plant will continue to meet the full intent of all regulatory obligations for post-closure care of these facilities. Section 2.0 provides the technical justification for each proposed permit modification. The proposed changes to permit language are provided in Section 3.0 (S-3 Ponds), Section 4.0 (Oil Landfarm), and Section 5.0 (Bear Creek Burial Grounds). Sections 6.0 and 7.0 reference updated and revised procedures for groundwater sampling, and monitoring well plugging and abandonment, respectively. Appendix A includes all proposed revisions to the PCP Attachments.

  15. Social and interpersonal relationship modifications after renal transplant. A statistic and epidemiologic evaluation.

    PubMed

    Famà, F; Micali, E; Linard, C; Venuti, M D; Costantino, G; Gioffrè-Florio, M

    2013-12-01

    Kidney and liver transplants are the most frequent transplantation procedures carried out in Italy. We report the result of an epidemiological study on kidney transplanted patients resident in the Province of Messina (Italy). Seventy-five patients were enrolled between June 2010 march 2011, interviewed and evaluated using an adapted Italian version short-form 36. Socio-economic characteristics, quality of life modifications and involvement in transplant-related charities were studied. The follow-up period was ranging between 52 and 356 months. All subjects gave written informed consent and all results were analysed by chi-square test. No statistically significant differences were found between sexes, social and interpersonal relationship modifications. The benefits obtained on quality of life after transplantation is the prerogative of a small percentage of patients and is related to medium and high socio-economic conditions. The possibility of avoiding the haemodialysis represents the primary benefit for the totality of patients.

  16. 48 CFR 52.214-23 - Late submissions, modifications, revisions, and withdrawals of technical proposals under two-step...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... reach the Government office designated in the request for technical proposals by the time specified in... such proposal received at the Government office designated in the request for technical proposals after... received at the initial point of entry to the Government infrastructure not later than 5:00 p.m. one...

  17. A Proposed Methodology for Contextualised Evaluation in Higher Education

    ERIC Educational Resources Information Center

    Nygaard, Claus; Belluigi, Dina Zoe

    2011-01-01

    This paper aims to inspire stakeholders working with quality of higher education (such as members of study boards, study programme directors, curriculum developers and teachers) to critically consider their evaluation methods in relation to a focus on student learning. We argue that many of the existing methods of evaluation in higher education…

  18. Flight evaluation of modifications to a digital electronic engine control system in an F-15 airplane

    NASA Technical Reports Server (NTRS)

    Burcham, F. W., Jr.; Myers, L. P.; Zeller, J. R.

    1983-01-01

    The third phase of a flight evaluation of a digital electronic engine control system in an F-15 has recently been completed. It was found that digital electronic engine control software logic changes and augmentor hardware improvements resulted in significant improvements in engine operation. For intermediate to maximum power throttle transients, an increase in altitude capability of up to 8000 ft was found, and for idle to maximum transients, an increase of up to 4000 ft was found. A nozzle instability noted in earlier flight testing was investigated on a test engine at NASA Lewis Research Center, a digital electronic engine control software logic change was developed and evaluated, and no instability occurred in the Phase 3 flight evaluation. The backup control airstart modification was evaluated, and gave an improvement of airstart capability by reducing the minimum airspeed for successful airstarts by 50 to 75 knots.

  19. Flight evaluation of modifications to a digital electronic engine control system in an F-15 airplane

    NASA Technical Reports Server (NTRS)

    Burcham, F. W., Jr.; Myers, L. P.; Zeller, J. R.

    1983-01-01

    The third phase of a flight evaluation of a digital electronic engine control system in an F-15 has recently been completed. It was found that digital electronic engine control software logic changes and augmentor hardware improvements resulted in significant improvements in engine operation. For intermediate to maximum power throttle transients, an increase in altitude capability of up to 8000 ft was found, and for idle to maximum transients, an increase of up to 4000 ft was found. A nozzle instability noted in earlier flight testing was investigated on a test engine at NASA Lewis Research Center, a digital electronic engine control software logic change was developed and evaluated, and no instability occurred in the Phase 3 flight evaluation. The backup control airstart modification was evaluated, and gave an improvement of airstart capability by reducing the minimum airspeed for successful airstarts by 50 to 75 knots.

  20. CRITERIA FOR EVALUATION OF PROPOSED PROTOZOAN DETECTION METHODS

    EPA Science Inventory

    There has been a proliferation of techniques and methods reported for analysis of water samples to determine the presence of the protozoan pathogens Cryptosporidium parvum and Giardia lamblia. Many of the proposed methods are presented as complete procedures, which include sampli...

  1. CRITERIA FOR EVALUATION OF PROPOSED PROTOZOAN DETECTION METHODS

    EPA Science Inventory

    There has been a proliferation of techniques and methods reported for analysis of water samples to determine the presence of the protozoan pathogens Cryptosporidium parvum and Giardia lamblia. Many of the proposed methods are presented as complete procedures, which include sampli...

  2. CRITERIA FOR EVALUATION OF PROPOSED PROTOZOAN DETECTION METHODS.

    EPA Science Inventory

    There has been a proliferation of techniques and methods reported for analysis of water samples to determine the presence of the protozoan pathogens Cryptosporidium parvum and Giardia lamblia. Many of the proposed methods are presented as complete procedures, which include sampli...

  3. 7 CFR 3406.20 - Evaluation criteria for research proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... new to the entire field of study? 10 points. (4) Products and results—Are the expected products and... ongoing related research? If the proposed project is a continuation of a current line of study or... previous stage of study? Are the procedures scientifically and managerially sound? Are potential pitfalls...

  4. 7 CFR 3406.20 - Evaluation criteria for research proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... new to the entire field of study? 10 points. (4) Products and results—Are the expected products and... ongoing related research? If the proposed project is a continuation of a current line of study or... previous stage of study? Are the procedures scientifically and managerially sound? Are potential pitfalls...

  5. CRITERIA FOR EVALUATION OF PROPOSED PROTOZOAN DETECTION METHODS.

    EPA Science Inventory

    There has been a proliferation of techniques and methods reported for analysis of water samples to determine the presence of the protozoan pathogens Cryptosporidium parvum and Giardia lamblia. Many of the proposed methods are presented as complete procedures, which include sampli...

  6. Evaluation of Lower Umatilla River Channel Modifications Below Three Mile Dam, 1984 Annual Progress Report.

    SciTech Connect

    Nigro, Anthony A.; Ward, David L.

    1985-05-01

    This report summarizes results of the first year of a study initiated in September 1984 to evaluate the adequacy of channel modifications made in the lower Umatilla River to improve adult anadromous salmonid passage to Three Mile Dam (RKm 5.6), determine if fish passage or delay problems exist at Three Mile Dam and recommend site specific corrective measures if needed. Movements of steelhead (Salmo gairdneri) were monitored using mark and recapture and radio telemetry techniques. Thirty-four steelhead were marked with T-anchor tags and released in the lower river. Fifteen of those marked were also fitted with radio transmitters. Three radiotagged steelhead migrated through channel modifications to Three Mile Dam. Two of these fish migrated to the dam in less than 26 hours, but held just below the dam for 7 and 10 days before entering the ladders. The third steelhead delayed for 30 days and entered the west ladder within 24 hours of arrival at the dam. Two other radiotagged steelhead moved upstream through some of the channel modifications but did not migrate to the dam. Only one of 19 marked steelhead not fitted with transmitters was recovered at Three Mile Dam. 14 refs., 18 figs., 3 tabs.

  7. Evaluation of textiles proposed for spacecraft crew apparel

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1976-01-01

    Textiles proposed for spacecraft wearing apparel were tested for possible primary irritancy and allergenicity using guinea pigs and human subjects. The materials submitted for testing were: (1) blue, loosely knit fabric of a copolymer of chlorotrifluoroethylene and ethylene (CTFE), (2) a white fabric, 100% cotton double knit, treated with fire retardant Tetrakis (hydroxymethyl) phosphonium hydroxide/ammonia, and (3) a gold colored polyimide fabric. There were no adverse reactions to any of the fabrics.

  8. Technical evaluation of the CG-47201 6V-92 detroit diesel electronic control (DDEC) propulsion modification. Final report

    SciTech Connect

    Latas, R.M.

    1995-03-01

    This report describes the testing and evaluation (TE) of the CG-47201 6V-92 DDEC Propulsion Modification that was conducted at Coast Guard Station Cape May, New Jersey, during the period 8-12 November 1994.

  9. Evaluation of cloud shading effects on the generation and modification of mesoscale circulations

    NASA Technical Reports Server (NTRS)

    Segal, M.; Song, J. L.; Pielke, R. A.; Purdom, J. F. W.; Mahrer, Y.

    1986-01-01

    This study presents scale analysis and numerical model evaluations of the impact of cloud shading on (1) the development of sea breeze and thermally induced upslope flows and (2) the generation of mesoscale circulations between cloudy areas adjacent to clear areas. Based on the assumption of modifications of solar and longwave radiation which are typical for some overcast conditions, it was found that the reduction in the first type of circulation is significant and most noticeable in the vertical velocities. In the second case, thermally induced circulations in favorable conditions appear to approach the typical intensity of the sea breeze.

  10. 48 CFR 1515.305-71 - Documentation of proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... evaluation documentation shall include: (a) Score sheets prepared by each individual team member must be made... specifically developed for the solicitation; and (b) A statement that the respective team members are free from actual or potential personal conflicts of interest, and are in compliance with the Office of...

  11. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL.... (a) In making a decision whether to provide financial support, NIST shall review and evaluate all... NIST research results and expertise in the technical areas noted in these procedures? (3) Technology...

  12. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL.... (a) In making a decision whether to provide financial support, NIST shall review and evaluate all... NIST research results and expertise in the technical areas noted in these procedures? (3) Technology...

  13. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL.... (a) In making a decision whether to provide financial support, NIST shall review and evaluate all... NIST research results and expertise in the technical areas noted in these procedures? (3) Technology...

  14. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL.... (a) In making a decision whether to provide financial support, NIST shall review and evaluate all... NIST research results and expertise in the technical areas noted in these procedures? (3) Technology...

  15. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL.... (a) In making a decision whether to provide financial support, NIST shall review and evaluate all... NIST research results and expertise in the technical areas noted in these procedures? (3) Technology...

  16. 76 FR 33395 - 30-Day Notice of Proposed Information Collections: ECA Sports & Culture Evaluation Surveys

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... Notice of Proposed Information Collections: ECA Sports & Culture Evaluation Surveys ACTION: Notice of... Information Collection: Sports & Culture Evaluation, Between the Lines (BTL) Survey. OMB Control Number: None... Respond: Voluntary. Title of Information Collection: Sports & Culture Evaluation, Sports Envoys Survey...

  17. 77 FR 6168 - 60-Day Notice of Proposed Information Collection: English Language Evaluation Surveys, OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Notice of Proposed Information Collection: English Language Evaluation Surveys, OMB Control Number 1405... Information Collection: English Language Evaluation: Fulbright English Teaching Assistantship (ETA) Program...: Voluntary. Title of Information Collection: English Language Evaluation: English Language Specialist...

  18. Reduced thrombogenicity of nitinol stents--in vitro evaluation of different surface modifications and coatings.

    PubMed

    Tepe, Gunnar; Schmehl, Joerg; Wendel, Hans P; Schaffner, Sivio; Heller, Stephan; Gianotti, Marc; Claussen, Claus D; Duda, Stephan H

    2006-02-01

    The material and the surface patterns of intravascular stents play a pivotal role in activating platelets and triggering adherence of inflammatory cells that consecutively leads to renarrowing caused by neointimal hyperplasia. To improve these features, besides mechanical and chemical modifications, ways of masking the stent by covering have been developed. In addition, polymer-coated stents are used as vehicle for local drug delivery. But as substances used for this application are described to possess an inflammatory potential, this aspect has to be evaluated. In the present study we compared different approaches to surface alterations applied to a nitinol stent design. Besides commonly used techniques like passivation and electropolishing, we evaluated coatings with heparin, aluminium and a polyurethane polymer regarding their thrombogenic and inflammatory characteristics. By weaving thin elastomer fibres a graft was generated. The previously described Chandler loop was used to simulate arterial flow conditions ex vivo using rotating PVC tubings filled with human blood. All stents received 120 min of blood contact. To determine thrombocyte activation and inflammatory reaction, the platelet count and levels of beta-TG, TAT and PMN-elastase were assessed. Scanning electron microscopy was used to visualize the reactions. Mechanical polishing and passivation did not improve the stent surface characteristics while sandblasting, electropolishing and aluminium covering decreased activation of the coagulation cascade. In terms of thrombogenicity, the heparin coating had no beneficial effect. The lowest thrombogenic potential was found in the Polyurethane-coated stent group. All stents showed similar levels of polymorph nuclear granulocyte elastase except for the membrane design. While mechanical and chemical modifications are able to reduce thrombogenicity, coating with this particular polyurethane polymer seems to be superior to these approaches regarding the

  19. Ecological evaluation of proposed dredged material from Richmond Harbor

    SciTech Connect

    Pinza, M.R.; Ward, J.A.; Mayhew, H.L.; Word, J.Q.; Niyogi, D.K.; Kohn, N.P.

    1992-10-01

    During the summer of 1991, Battelle/Marine Sciences Laboratory (MSL) was contracted to conduct sampling and testing of sediments proposed for dredging of Richmond Harbor, California. The MSL collected sediment cores to a depth of {minus}40 ft MLLW ({minus}38 ft + 2 ft overdepth) from 28 (12-in. core) and 30 (4-in. core) stations. The sediment cores were allocated to six composite samples referred to as sediment treatments, which were then subjected to physical, chemical, toxicological, and bioaccumulation testing. Physical and chemical parameters included grain size, total organic carbon (TOC), total volatile solids (TVS), oil and grease, total petroleum hydrocarbons (TPH), polynuclear aromatic hydrocarbons (PAH), chlorinated pesticides, polychlorinated biphenyis (PCBs), priority pollutant metals, and butyltins. The results from the test treatments were compared to results from five reference treatments representative of potential in-bay and offshore disposal sites.

  20. Ecological evaluation of proposed dredged material from Richmond Harbor

    SciTech Connect

    Pinza, M R; Ward, J A; Mayhew, H L; Word, J Q; Niyogi, D K; Kohn, N P

    1992-10-01

    During the summer of 1991, Battelle/Marine Sciences Laboratory (MSL) was contracted to conduct sampling and testing of sediments proposed for dredging of Richmond Harbor, California. The MSL collected sediment cores to a depth of [minus]40 ft MLLW ([minus]38 ft + 2 ft overdepth) from 28 (12-in. core) and 30 (4-in. core) stations. The sediment cores were allocated to six composite samples referred to as sediment treatments, which were then subjected to physical, chemical, toxicological, and bioaccumulation testing. Physical and chemical parameters included grain size, total organic carbon (TOC), total volatile solids (TVS), oil and grease, total petroleum hydrocarbons (TPH), polynuclear aromatic hydrocarbons (PAH), chlorinated pesticides, polychlorinated biphenyis (PCBs), priority pollutant metals, and butyltins. The results from the test treatments were compared to results from five reference treatments representative of potential in-bay and offshore disposal sites.

  1. Two-Dimensional Hydrodynamic Modeling and Analysis of the Proposed Channel Modifications and Grade Control Structure on the Blue River near Byram's Ford Industrial Park, Kansas City, Missouri

    USGS Publications Warehouse

    Huizinga, Richard J.

    2007-01-01

    The Blue River Channel Modification project being implemented by the U.S. Army Corps of Engineers (USACE) is intended to provide flood protection within the Blue River valley in the Kansas City, Mo., metropolitan area. In the latest phase of the project, concerns have arisen about preserving the Civil War historic area of Byram's Ford and the associated Big Blue Battlefield while providing flood protection for the Byram's Ford Industrial Park. In 1996, the USACE used a physical model built at the Waterways Experiment Station (WES) in Vicksburg, Miss., to examine the feasibility of a proposed grade control structure (GCS) that would be placed downstream from the historic river crossing of Byram's Ford to provide a subtle transition of flow from the natural channel to the modified channel. The U.S. Geological Survey (USGS), in cooperation with the USACE, modified an existing two-dimensional finite element surface-water model of the river between 63d Street and Blue Parkway (the 'original model'), used the modified model to simulate the existing (as of 2006) unimproved channel and the proposed channel modifications and GCS, and analyzed the results from the simulations and those from the WES physical model. Modifications were made to the original model to create a model that represents existing (2006) conditions between the north end of Swope Park immediately upstream from 63d Street and the upstream limit of channel improvement on the Blue River (the 'model of existing conditions'). The model of existing conditions was calibrated to two measured floods. The model of existing conditions also was modified to create a model that represents conditions along the same reach of the Blue River with proposed channel modifications and the proposed GCS (the 'model of proposed conditions'). The models of existing conditions and proposed conditions were used to simulate the 30-, 50-, and 100-year recurrence floods. The discharge from the calibration flood of May 15, 1990, also

  2. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: Evaluation of applications and proposals. 219.123 Section 219.123 National Defense Department of Defense....123 Early termination of research support: Evaluation of applications and proposals. (a) The... decisions about supporting or approving applications or proposals covered by this policy the department or...

  3. 15 CFR 27.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... terms of this policy. (b) In making decisions about supporting or approving applications or proposals...: Evaluation of applications and proposals. 27.123 Section 27.123 Commerce and Foreign Trade Office of the...: Evaluation of applications and proposals. (a) The department or agency head may require that department or...

  4. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... evaluate proposals and select the best one? 51.16 Section 51.16 Parks, Forests, and Public Property... Procedures § 51.16 How will the Director evaluate proposals and select the best one? (a) The Director will apply the selection factors set forth in § 51.17 by assessing each timely proposal under each of the...

  5. Evaluation of Lower Umatilla River Channel Modifications Below Three Mile Dam, 1985 : Final Report.

    SciTech Connect

    Nigro, Anthony A.; Ward, David L.

    1986-02-01

    The second year of a study to evaluate passage of adult anadromous salmonids through channel modifications made in the lower Umatilla River below Three Mile Dam was terminated due to inadequate returns of upriver bright fall chinook salmon (Oncorhynchus tshawytscha). Sampling of returning adults was discontinued on November 15, when it became apparent that insufficient numbers of fall chinook salmon were returning to the river to allow the evaluation. Stream flows were monitored through December 31 to document flow conditions present during the period when returns of fall chinook salmon were anticipated. This report summarizes results prior to termination of the study. Arrival of upriver bright fall chinook salmon at the mouth of the Umatilla River was monitored by boat electrofishing below river kilometer (RKm) 1. Attempts to examine passage of salmon through channel modifications were made using marked and radiotagged fish. Forty-eight jack and six adult salmon were marked and released above a weir placed at RKm 2. Five of the adults were also fitted with radiotransmitters. Thirty fall chinook were collected while boat electrofishing at the mouth of the Umatilla River. Fifteen of those collected were captured between October 14 and October 18, after flows had reached 150 cfs. No salmon were captured at the weir or at Three Mile Dam until flows reached 150 cfs. One radiotagged salmon migrated to the dam at flows of 245 cfs. Only one marked jack salmon was recovered at Three Mile Dam.

  6. School violence: evaluation and proposal of teaching staff.

    PubMed

    Domínguez Alonso, José; López-Castedo, Antonio; Pino Juste, Margarita

    2009-10-01

    The aim of this work was to evaluate the frequency of violent behaviors in educational centers, according to self-report of the teaching staff. To that end, a questionnaire about school violence was administered to a sample of 616 teachers working in primary and secondary schools in Galicia, Spain. Disruptive and antisocial behaviors in the student population were reported to affect the teaching effort negatively. The compiled data indicate verbal aggression is the most common form of violence used by the student population and reveal the dissatisfaction of teaching staff not prepared for this challenge. Teachers felt the need to devise new effective responses to promote concord in educational communities.

  7. Evaluation of proposed Skylab and SSP soap products.

    NASA Technical Reports Server (NTRS)

    Durfee, R. L.; Spurlock, J. M.; Whitmore, F. C.

    1973-01-01

    Four candidate cleansing agents evaluated in terms of potential hazards to crew members included two soaps (Neutrogena bar soap and Olive Leaf Liquid), one nonfoaming surfactant (Miranol JEM), and one laundry detergent (sodium dodecylbenzene sulfonate). None of the four exhibited adverse dermatological effects from skin patch tests or supported growth of potentially pathogenic microorganisms. Aqueous solutions of Neutrogena did support a mold species. Neutrogena and Miranol JEM were used in a simulated Skylab personal hygiene regimen with no adverse effects on skin or skin microflora. Based on our results, each of these agents appear to be a promising candidate material for the use intended.

  8. Evaluation of proposed Skylab and SSP soap products.

    NASA Technical Reports Server (NTRS)

    Durfee, R. L.; Spurlock, J. M.; Whitmore, F. C.

    1973-01-01

    Four candidate cleansing agents evaluated in terms of potential hazards to crew members included two soaps (Neutrogena bar soap and Olive Leaf Liquid), one nonfoaming surfactant (Miranol JEM), and one laundry detergent (sodium dodecylbenzene sulfonate). None of the four exhibited adverse dermatological effects from skin patch tests or supported growth of potentially pathogenic microorganisms. Aqueous solutions of Neutrogena did support a mold species. Neutrogena and Miranol JEM were used in a simulated Skylab personal hygiene regimen with no adverse effects on skin or skin microflora. Based on our results, each of these agents appear to be a promising candidate material for the use intended.

  9. Preliminary evaluation of a proposed injection site in Mellones

    SciTech Connect

    Ortiz, N.V.; Rada, H.M.

    1996-08-01

    A hydrogeological evaluation was carried out in the Melones area to determine the feasibility of disposing brackish water and brines associated with oil production activities. The region is located towards north-central Hamaca, in the Anzoategui state, and covers an area of approximately 454 km{sup 2}. The study was based on the examination and interpretation of available stratigraphic and structural maps, well logs and formation water analysis. Engineering properties were estimated from 42 wells, selected from a total of 575 wells, where complete sets of well logs were available. The most suitable injection interval, integrated by the 02/3, D1-D2-D3-D4 and E1-E2 sands from the upper part of the Oficina Formation, was selected by addressing certain technical requirements for suitable potential disposal sites and injection intervals. A two-dimensional finite difference flow model was used to simulate the long-term hydraulic head buildup under projected operating conditions. After examination of the important characteristics considered in the evaluation process, it appears that the Melones area favorably meets most criteria.

  10. Hazardous-waste nightmare. [Evaluation of legislative proposals

    SciTech Connect

    Alexander, T.

    1980-04-21

    Mr. Alexander points out that, even in the absence of Federal regulation, hazardous wastes would be a major problem for companies. Many have been driven to desperate measures even to find someplace to put the 125 billion pounds of such wastes that are produced each year - but that nobody wants nearby. EPA recently began promulgating final regulations implementing the Resource Conservation and Recovery Act passed by Congress in 1976; these regulations will mandate technical standards for all future waste sites as well as a cradle to grave system for tracking major hazardous wastes to their ultimate disposition. But much of Washington's new interest seems to be a response to the charge that government too long overlooked the menace in old wastes; so, they are now turning to unusually primitive measures aimed at industry's past practice. The Justice Department has mobilized a fourteen-lawyer section to track down and prosecute companies for transgressions. Several bills are making their way through committees and, if enacted, could confront even very large industries with the choice of finding some new way of dealing with old wastes or going out of business. In discussing these proposals and touching briefly on the technical side of how wastes reach the aquifers, Mr. Alexander says that little is known about the extent of trace-chemical contamination - and, although it's time Washington ended its neglect of the problem, the extremely punitive measures are probably not called for.

  11. Evaluation of materials proposed for use in space flight

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1981-01-01

    The cutaneous primary irritancy and allergenicity potential of cotton shirts/fabrics treated with flame retardants were evaluated in order to establish their suitability for spacecraft crew use. Twenty-five volunteer human subjects were patch tested on the back utilizing standard methodology, with both treated and untreated cotton fabric. The fabric was treated with tetrakis (hydroxymethyl) phosphonium hydroxide and subsequently cured with gaseous ammonia. The final treatment comprised adding on dicyandiamine phosphoric acid. None of the individuals experienced primary irritant or allergic reactions attributable to the fabric during induction or challenge patch testing. Likewise, there were no reactions to treated or untreated fabric patches placed on ten subjects of the usage panel at the conclusion of the study.

  12. Evaluation of proposed Skylab and SSP soap products

    NASA Technical Reports Server (NTRS)

    Whitmore, F. C.; Durfee, R. L.; Spurlock, J. M.

    1973-01-01

    Three personal hygiene cleansing agents and one laundry detergent (sodium dodecyl benzene sulfonate), which are all candidates for use on long-duration space missions, were evaluated in terms of dermatological effects on human subjects and effects on microbiological species. None of the four materials exhibited adverse dermatological effects from either skin patch tests of two weeks duration or a simulated Skylab personal hygiene regimen of up to four weeks duration. No significant alterations in skin microflora during the use regimen were found. None of the four materials were found to serve as microbiological support media for the species tested, but a species of air-borne mold was observed to grow rapidly in a neutralized aqueous solution. None of the candidate agents was found to be strongly biocidal.

  13. Validation of a proposal for evaluating hospital infection control programs.

    PubMed

    Silva, Cristiane Pavanello Rodrigues; Lacerda, Rúbia Aparecida

    2011-02-01

    To validate the construct and discriminant properties of a hospital infection prevention and control program. The program consisted of four indicators: technical-operational structure; operational prevention and control guidelines; epidemiological surveillance system; and prevention and control activities. These indicators, with previously validated content, were applied to 50 healthcare institutions in the city of São Paulo, Southeastern Brazil, in 2009. Descriptive statistics were used to characterize the hospitals and indicator scores, and Cronbach's α coefficient was used to evaluate the internal consistency. The discriminant validity was analyzed by comparing indicator scores between groups of hospitals: with versus without quality certification. The construct validity analysis was based on exploratory factor analysis with a tetrachoric correlation matrix. The indicators for the technical-operational structure and epidemiological surveillance presented almost 100% conformity in the whole sample. The indicators for the operational prevention and control guidelines and the prevention and control activities presented internal consistency ranging from 0.67 to 0.80. The discriminant validity of these indicators indicated higher and statistically significant mean conformity scores among the group of institutions with healthcare certification or accreditation processes. In the construct validation, two dimensions were identified for the operational prevention and control guidelines: recommendations for preventing hospital infection and recommendations for standardizing prophylaxis procedures, with good correlation between the analysis units that formed the guidelines. The same was found for the prevention and control activities: interfaces with treatment units and support units were identified. Validation of the measurement properties of the hospital infection prevention and control program indicators made it possible to develop a tool for evaluating these programs

  14. Evaluation of exercise-respiratory system modifications and integration schemes for physiological systems

    NASA Technical Reports Server (NTRS)

    Gallagher, R. R.

    1974-01-01

    Exercise subroutine modifications are implemented in an exercise-respiratory system model yielding improvement of system response to exercise forcings. A more physiologically desirable respiratory ventilation rate in addition to an improved regulation of arterial gas tensions and cerebral blood flow is observed. A respiratory frequency expression is proposed which would be appropriate as an interfacing element of the respiratory-pulsatile cardiovascular system. Presentation of a circulatory-respiratory system integration scheme along with its computer program listing is given. The integrated system responds to exercise stimulation for both nonstressed and stressed physiological states. Other integration possibilities are discussed with respect to the respiratory, pulsatile cardiovascular, thermoregulatory, and the long-term circulatory systems.

  15. 43 CFR 404.22 - How will Reclamation evaluate my full proposal?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false How will Reclamation evaluate my full... RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Overview § 404.22 How will Reclamation evaluate my full proposal? (a) Reclamation will evaluate the full proposal to conduct an appraisal...

  16. 43 CFR 404.22 - How will Reclamation evaluate my full proposal?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false How will Reclamation evaluate my full... RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Overview § 404.22 How will Reclamation evaluate my full proposal? (a) Reclamation will evaluate the full proposal to conduct an appraisal...

  17. 43 CFR 404.22 - How will Reclamation evaluate my full proposal?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true How will Reclamation evaluate my full... RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Overview § 404.22 How will Reclamation evaluate my full proposal? (a) Reclamation will evaluate the full proposal to conduct an appraisal...

  18. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How will the Secretary evaluate a proposed gaming establishment? 292.21 Section 292.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ECONOMIC... Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed gaming...

  19. 36 CFR 1206.62 - Who reviews and evaluates grant proposals?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Who reviews and evaluates... NHPRC Grants § 1206.62 Who reviews and evaluates grant proposals? (a) State boards. State historical records advisory boards may evaluate your proposal according to Commission grant opportunity announcements...

  20. 36 CFR 1206.62 - Who reviews and evaluates grant proposals?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Who reviews and evaluates... NHPRC Grants § 1206.62 Who reviews and evaluates grant proposals? (a) State boards. State historical records advisory boards may evaluate your proposal according to Commission grant opportunity announcements...

  1. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the Secretary evaluate a proposed gaming establishment? 292.21 Section 292.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ECONOMIC... Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed gaming...

  2. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed...

  3. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed...

  4. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed...

  5. 7 CFR 1487.6 - What are the criteria for evaluating proposals?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... potential trade impact of the proposed project on market retention, market access, and market expansion... evaluate each proposal against the factors described in paragraph (a) of this section. The purpose of...

  6. 7 CFR 1487.6 - What are the criteria for evaluating proposals?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... barrier; (2) The potential trade impact of the proposed project on market retention, market access, and... completeness and will evaluate each proposal against the factors described in paragraph (a) of this...

  7. 77 FR 31584 - Proposed Information Collection; Comment Request; Generic Clearance for Program Evaluation Data...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... National Institute of Standards and Technology Proposed Information Collection; Comment Request; Generic Clearance for Program Evaluation Data Collection AGENCY: National Institute of Standards and Technology... take this opportunity to comment on proposed and/or continuing information collections, as required...

  8. [Profile Orifice Shapers. A valid instrument also for the root canal preparation of short teeth: proposal for a series modification].

    PubMed

    Marsico, E M; Rao Genovese, F

    2002-10-01

    The several endodontic instruments, currently used for the canal preparation with the crown-down technique, simplified only in part root canal therapy, but increased the costs. The authors examined the Profile Orefice Shapers Series, planned only for the preparation of the coronal third, and carried out a comparative analysis with other endodontic instruments currently available. Eighty-seven teeth with a 19 mm work lenght were selected for this study. Endodontic treatment was performed using exclusively Profile Orefice Shapers under constant irrigation with 2.5% sodium hypoclorite to clean and shape the canal and System B and Obtura II to obturate the root canal system. Postoperative films show an adequate root canal shaping and a complete apical seal. Endodontic therapy was simplified (only 5 instruments to obtain a good canal shaping); clinical time and costs were decreased. The authors obtained a good shaping and apical seal using the Profile Orefice Shapers in short teeth. The quality of the root canal therapy obtainable with these instruments is confirmed by radiographs. Some modifications are suggested: increase of instruments working length, introduction of 3 extra intermediate instruments and restriction of working part diameter (1 mm) and operative procedures that lead to obtain an excellent and complete use of these instruments.

  9. Two case reports of perineal hernia after laparoscopic abdominoperineal resection with a proposed modification to the operative technique

    PubMed Central

    Ewan, LC; Charleston, PJ

    2014-01-01

    Perineal hernia is a rare complication following laparoscopic abdominoperineal resection (APR) for rectal cancer. We present two case reports of perineal hernia following laparoscopic APR and discuss their management. We suggest that they developed because the pelvic peritoneum was left open during laparoscopic APR and propose that closure of the pelvic peritoneum should be routine in this operation. PMID:24780656

  10. Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations.

    PubMed Central

    Rodwell, J D; Alvarez, V L; Lee, C; Lopes, A D; Goers, J W; King, H D; Powsner, H J; McKearn, T J

    1986-01-01

    A strategy for covalent modification of monoclonal antibodies utilizing the oxidized oligosaccharide moieties on the molecule was evaluated and compared to more conventional methods. As judged by quantitative in vitro measurements, a monoclonal antibody conjugate prepared via the oligosaccharides retained the homogeneous antigen binding property and affinity of the unmodified antibody. In contrast, conjugates of the same antibody, modified to the same degree on either lysines or aspartic and glutamic acid side chains, were heterogeneous in their antigen binding and had lowered affinity. In vivo biodistribution and nuclear-imaging experiments were also performed with a second monoclonal antibody and a tumor xenograft model. Antibodies modified on the oligosaccharides with either a peptide labeled with iodine-125 or a diethylenetriaminepentaacetic acid chelate with indium-111 localize into target tumors more efficiently than the same antibody radiolabeled on either tyrosines or lysines. These in vivo results, when compared to those reported in the literature for conventionally modified antibodies, suggest that oligosaccharide modification of monoclonal antibodies is a preferred method of preparing conjugates. Images PMID:3458222

  11. Evaluation of the test method activated sludge, respiration inhibition test proposed by the OECD

    SciTech Connect

    Yoshioka, Y.; Nagase, H.; Ose, Y.; Sato, T.

    1986-12-01

    The test method of activated sludge, respiration inhibition test proposed by the OECD was critically carried out and compared with other test methods. Investigation of test conditions showed that the moderate deviation from the test conditions defined by the OECD Test Guidelines did not have much effect on the result, and some modifications were proposed to improve the method. This method had a poor detection limit compared with the LC50 test with Oryzias latipes and EC50 of the growth inhibition test with Tetrahymena pyriformis. The susceptivity of the method was particularly poor for the chemicals which were highly toxic in the other two tests.

  12. 75 FR 9279 - Proposed Information Collection (Survey of Satisfaction With the Disability Evaluation System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF VETERANS AFFAIRS Proposed Information Collection (Survey of Satisfaction With the Disability Evaluation System (DES... of Satisfaction with the Disability Evaluation System (DES). OMB Control Number: 2900-New (DES)....

  13. 76 FR 57767 - Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for... NRC Generic Letter 2011- XX: Seismic Risk Evaluations for Operating Reactors. This action is...

  14. 77 FR 12322 - Notice of Submission of Proposed Information Collection to OMB; Evaluation of the Veterans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... Veterans Homelessness Prevention Demonstration AGENCY: Office of the Chief Information Officer, HUD. ACTION... information required to evaluate the Veterans Homelessness Prevention Demonstration (VHPD). The Department... following information: Title of Proposal: Evaluation of the Veterans Homelessness Prevention...

  15. Modifications and evaluation of smell and taste functions in total laryngectomy: systematic review.

    PubMed

    Caldas, Ada Salvetti Cavalcanti; Facundes, Vera Lúcia Dutra; Melo, Thais Myriam Aragão; Dourado Filho, Mário Genuíno; Pinheiro Júnior, Paulo Fernando; Silva, Hilton Justino da

    2011-03-01

    The aim of this study was to systematically review the alterations in smell and taste functions in individuals who underwent total laryngectomy, as well as to identify in the literature some aspects involved in the evaluation of these functions in this population. We performed a systematic review on the databases Medline, LILACS and SciELO, and this data search occurred in October/2010. The search used keywords and free terms, and retrieved 84 articles, 79 from Medline, via Pubmed, and five form LILACS and SciELO. Sixteen of these articles were selected. Most studies in this review attested decline in sensory of smell and taste functions in individuals who underwent total laryngectomy and, although there is consensus regarding the damage caused to these functions by the nasal airflow interruption, it is not yet possible to evidence details in the mechanisms and structures involved, especially regarding the modifications in the olfactory mucous.

  16. Modification and evaluation of a Barnes-type objective analysis scheme for surface meteorological data

    NASA Technical Reports Server (NTRS)

    Smith, D. R.

    1982-01-01

    The Purdue Regional Objective Analysis of the Mesoscale (PROAM) is a Barness-type scheme for the analysis of surface meteorological data. Modifications are introduced to the original version in order to increase its flexibility and to permit greater ease of usage. The code was rewritten for an interactive computer environment. Furthermore, a multiple iteration technique suggested by Barnes was implemented for greater accuracy. PROAM was subjected to a series of experiments in order to evaluate its performance under a variety of analysis conditions. The tests include use of a known analytic temperature distribution in order to quantify error bounds for the scheme. Similar experiments were conducted using actual atmospheric data. Results indicate that the multiple iteration technique increases the accuracy of the analysis. Furthermore, the tests verify appropriate values for the analysis parameters in resolving meso-beta scale phenomena.

  17. Evaluation of an interprofessional team-based learning nutrition and lifestyle modification course.

    PubMed

    Pogge, Elizabeth

    2016-01-01

    An interprofessional, team-based learning elective was developed, implemented, and evaluated to determine the knowledge gained, attitude changes towards interprofessional education, and overall satisfaction with the course. Thirty participants, 14 osteopathic medicine students and 16 pharmacy students, completed the course. The majority of students (88-96%) responded favourably to the team-based learning aspects of the course. Knowledge about nutrition and lifestyle modification was significantly improved by taking the course. Overall, students' readiness for and perception of interprofessional learning improved by taking the course, although not all improvements were statistically significant. In conclusion, the benefits of team-based learning, such as enhancing communication and teamwork skills, can enhance interprofessional education.

  18. Modification and evaluation of a Barnes-type objective analysis scheme for surface meteorological data

    NASA Technical Reports Server (NTRS)

    Smith, D. R.

    1982-01-01

    The Purdue Regional Objective Analysis of the Mesoscale (PROAM) is a Barness-type scheme for the analysis of surface meteorological data. Modifications are introduced to the original version in order to increase its flexibility and to permit greater ease of usage. The code was rewritten for an interactive computer environment. Furthermore, a multiple iteration technique suggested by Barnes was implemented for greater accuracy. PROAM was subjected to a series of experiments in order to evaluate its performance under a variety of analysis conditions. The tests include use of a known analytic temperature distribution in order to quantify error bounds for the scheme. Similar experiments were conducted using actual atmospheric data. Results indicate that the multiple iteration technique increases the accuracy of the analysis. Furthermore, the tests verify appropriate values for the analysis parameters in resolving meso-beta scale phenomena.

  19. Synthesis and evaluation of bioorthogonal pantetheine analogues for in vivo protein modification.

    PubMed

    Meier, Jordan L; Mercer, Andrew C; Rivera, Heriberto; Burkart, Michael D

    2006-09-20

    In vivo carrier protein tagging has recently become an attractive target for the site-specific modification of fusion systems and new approaches to natural product proteomics. A detailed study of pantetheine analogues was performed in order to identify suitable partners for covalent protein labeling inside living cells. A rapid synthesis of pantothenamide analogues was developed and used to produce a panel which was evaluated for in vitro and in vivo protein labeling. Kinetic comparisons allowed the construction of a structure-activity relationship to pinpoint the linker, dye, and bioorthogonal reporter of choice for carrier protein labeling. Finally bioorthogonal pantetheine analogues were shown to target carrier proteins with high specificity in vivo and undergo chemoselective ligation to reporters in crude cell lysate. The methods demonstrated here allow carrier proteins to be visualized and isolated for the first time without the need for antibody techniques and set the stage for the future use of carrier protein fusions in chemical biology.

  20. Evaluation of Grid Modification Methods for On- and Off-Track Sonic Boom Analysis

    NASA Technical Reports Server (NTRS)

    Nayani, Sudheer N.; Campbell, Richard L.

    2013-01-01

    Grid modification methods have been under development at NASA to enable better predictions of low boom pressure signatures from supersonic aircraft. As part of this effort, two new codes, Stretched and Sheared Grid - Modified (SSG) and Boom Grid (BG), have been developed in the past year. The CFD results from these codes have been compared with ones from the earlier grid modification codes Stretched and Sheared Grid (SSGRID) and Mach Cone Aligned Prism (MCAP) and also with the available experimental results. NASA's unstructured grid suite of software TetrUSS and the automatic sourcing code AUTOSRC were used for base grid generation and flow solutions. The BG method has been evaluated on three wind tunnel models. Pressure signatures have been obtained up to two body lengths below a Gulfstream aircraft wind tunnel model. Good agreement with the wind tunnel results have been obtained for both on-track and off-track (up to 53 degrees) cases. On-track pressure signatures up to ten body lengths below a Straight Line Segmented Leading Edge (SLSLE) wind tunnel model have been extracted. Good agreement with the wind tunnel results have been obtained. Pressure signatures have been obtained at 1.5 body lengths below a Lockheed Martin aircraft wind tunnel model. Good agreement with the wind tunnel results have been obtained for both on-track and off-track (up to 40 degrees) cases. Grid sensitivity studies have been carried out to investigate any grid size related issues. Methods have been evaluated for fully turbulent, mixed laminar/turbulent and fully laminar flow conditions.

  1. 77 FR 43899 - 60-Day Notice of Proposed Information Collection: Humphrey Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... Notice of Proposed Information Collection: Humphrey Evaluation Survey ACTION: Notice of request for... accordance with the Paperwork Reduction Act of 1995. Title of Information Collection: Humphrey Evaluation.... Originating Office: Bureau of Educational and Cultural Affairs, Office of Policy and Evaluation, Evaluation...

  2. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Evaluating proposals of foreign iron, steel... Evaluating proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured...

  3. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Evaluating proposals of foreign iron, steel... American Recovery and Reinvestment Act of 2009 § 176.110 Evaluating proposals of foreign iron, steel, and... cost of certain domestic iron, steel, and/or manufactured goods being unreasonable, in accordance with...

  4. 38 CFR 16.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... research support: Evaluation of applications and proposals. 16.123 Section 16.123 Pensions, Bonuses, and... research support: Evaluation of applications and proposals. (a) The department or agency head may require... materially failed to comply with the terms of this policy. (b) In making decisions about supporting or...

  5. 40 CFR 26.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of this policy. (b) In making decisions about supporting or approving applications or proposals...: Evaluation of applications and proposals. 26.123 Section 26.123 Protection of Environment ENVIRONMENTAL... Research Conducted or Supported by EPA § 26.123 Early termination of research support: Evaluation of...

  6. 28 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of this policy. (b) In making decisions about supporting or approving applications or proposals...: Evaluation of applications and proposals. 46.123 Section 46.123 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROTECTION OF HUMAN SUBJECTS § 46.123 Early termination of research support: Evaluation of...

  7. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... making decisions about supporting or approving applications or proposals covered by this policy the... 45 Public Welfare 1 2010-10-01 2010-10-01 false Early termination of research support: Evaluation... Research Subjects § 46.123 Early termination of research support: Evaluation of applications and proposals...

  8. 23 CFR 636.301 - How should proposal evaluation factors be selected?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false How should proposal evaluation factors be selected? 636.301 Section 636.301 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal Evaluation Factors § 636.301 How...

  9. 23 CFR 636.301 - How should proposal evaluation factors be selected?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false How should proposal evaluation factors be selected? 636.301 Section 636.301 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal Evaluation Factors § 636.301 How...

  10. 77 FR 69539 - 30-Day Notice of Proposed Information Collection: Humphrey Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... Notice of Proposed Information Collection: Humphrey Evaluation Survey ACTION: Notice of request for public comment and submission to OMB of proposed collection of information. SUMMARY: The Department of... Information Collection: Humphrey Evaluation Survey. OMB Control Number: None. Type of Request: New...

  11. Proposed Rule for Modification of Federal On Board Diagnostic Regulations for: Light Duty Vehicles, Light Duty Trucks, Medium Duty Passenger Vehicles, Complete Heavy Duty Vehicles and Engines Intended for Use in Heavy Duty Vehicles Weighing 14,000 Pounds

    EPA Pesticide Factsheets

    Following is information for the proposed rule for the Modification of Federal On Board Diagnostic Regulations for Light-Duty Vehicles, Light-Duty Trucks, etc. Includes links to Federal Register and final rule.

  12. Regulatory ecotoxicity testing of nanomaterials - proposed modifications of OECD test guidelines based on laboratory experience with silver and titanium dioxide nanoparticles.

    PubMed

    Hund-Rinke, Kerstin; Baun, Anders; Cupi, Denisa; Fernandes, Teresa F; Handy, Richard; Kinross, John H; Navas, José M; Peijnenburg, Willie; Schlich, Karsten; Shaw, Benjamin J; Scott-Fordsmand, Janeck J

    2016-12-01

    Regulatory ecotoxicity testing of chemicals is of societal importance and a large effort is undertaken at the OECD to ensure that OECD test guidelines (TGs) for nanomaterials (NMs) are available. Significant progress to support the adaptation of selected TGs to NMs was achieved in the context of the project MARINA ( http://www.marina-fp7.eu/ ) funded within the 7th European Framework Program. Eight OECD TGs were adapted based on the testing of at least one ion-releasing NM (Ag) and two inert NMs (TiO2). With the materials applied, two main variants of NMs (ion releasing vs. inert NMs) were addressed. As the modifications of the test guidelines refer to general test topics (e.g. test duration or measuring principle), we assume that the described approaches and modifications will be suitable for the testing of further NMs with other chemical compositions. Firm proposals for modification of protocols with scientific justification(s) are presented for the following tests: growth inhibition using the green algae Raphidocelis subcapitata (formerly: Pseudokirchneriella subcapitata; TG 201), acute toxicity with the crustacean Daphnia magna (TG 202), development toxicity with the fish Danio rerio (TG 210), reproduction of the sediment-living worm Lumbriculus variegatus (TG 225), activity of soil microflora (TGs 216, 217), and reproduction of the invertebrates (Enchytraeus crypticus, Eisenia fetida, TGs 220, 222). Additionally, test descriptions for two further test systems (root elongation of plants in hydroponic culture; test on fish cells) are presented. Ecotoxicological data obtained with the modified test guidelines for TiO2 NMs and Ag NM and detailed method descriptions are available.

  13. An open trial evaluating an attention bias modification program for overweight adults who binge eat.

    PubMed

    Boutelle, Kerri N; Monreal, Teresa; Strong, David R; Amir, Nader

    2016-09-01

    Binge eating is prevalent and is associated with significant psychiatric and medical comorbidities. To date, the most effective psychological treatments for individuals who binge eat are not effective for all patients and they do not result in significant weight loss. Dual process theories suggest that implicit factors, such as attention bias, may influence behavior, even when the behavior is in opposition to long-term goals. Attention bias modification programs have been tested in other areas of psychopathology, and could be utilized to improve outcomes for people who binge eat. Thus, the aim of this open trial was to conduct a preliminary evaluation of an attention bias modification program (ABM-Food) designed to train attention away from food cues. Adults who binge eat and were overweight or obese enrolled in an 8-week ABM-Food program, which consisted of one session in the lab each week and two training sessions at home. Nine participants completed the ABM-Food training program and the post-treatment assessment, and 8 completed the 3-month post-treatment assessment. Results showed that the ABM-Food program is a feasible and acceptable treatment for adults who binge eat. Initial effectiveness data showed decreases in weight, eating disorder symptoms, binge eating, loss of control and responsivity to food in the environment, as well as changes in attention bias. The majority of these effects remained at the 3-month follow-up time point. This study is limited by the single-group open label trial, and the small sample size. This open trial provides initial evidence for the feasibility, acceptability and effectiveness of ABM-Food for individuals who binge eat and are overweight or obese. Copyright © 2016. Published by Elsevier Ltd.

  14. Proposed modifications to the RCRA post-closure permit for the Upper East Fork Poplar Creek Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Upper East Fork Poplar Creek Hydrogeologic Regime (permit number TNHW-088, EPA ID No. TN3 89 009 0001). The modifications are proposed to: (1) revise the current text for two of the Permit Conditions included in Permit Section II - General Facility Conditions, and (2) update the PCP with revised versions of the Y-12 Plant Groundwater Protection Program (GWPP) technical field procedures included in several of the Permit Attachments. The updated field procedures and editorial revisions are Class 1 permit modifications, as specified in Title 40, Code of Federal Regulations (CFR) {section}270.42; Appendix I - Classification of Permit Modifications. These modifications are summarized below.

  15. Proposed modification to avoidance test with Eisenia fetida to assess metal toxicity in agricultural soils affected by mining activities.

    PubMed

    Delgadillo, Víctor; Verdejo, José; Mondaca, Pedro; Verdugo, Gabriela; Gaete, Hernán; Hodson, Mark E; Neaman, Alexander

    2017-06-01

    Use of avoidance tests is a quick and cost-effective method of assessing contaminants in soils. One option for assessing earthworm avoidance behavior is a two-section test, which consists of earthworms being given the choice to move between a test soil and a control substrate. For ecological relevance, tested soils should be field-contaminated soils. For practical reasons, artificial soils are commonly used as the control substrate. Interpretation of the test results compromised when the test soil and the artificial substrate differ in their physico-chemical properties other than just contaminants. In this study we identified the physico-chemical properties that influence avoidance response and evaluated the usefulness of adjusting these in the control substrate in order to isolate metal-driven avoidance of field soils by earthworms. A standardized two-section avoidance test with Eisenia fetida was performed on 52 uncontaminated and contaminated (Cu >155mgkg(-1), As >19mgkg(-1)) agricultural soils from the Aconcagua River basin and the Puchuncaví Valley in Chile. Regression analysis indicated that the avoidance response was determined by soil organic matter (OM), electrical conductivity (EC) and total soil Cu. Organic matter content of the artificial substrate was altered by peat additions and EC by NaCl so that these properties matched those of the field soils. The resultant EC80 for avoidance (indicative of soils of "limited habitat") was 433mg Cu kg(-1) (339 - 528mgkg(-1) 95% confidence intervals). The earthworm avoidance test can be used to assess metal toxicity in field-contaminated soils by adjusting physico-chemical properties (OM and EC) of the artificial control substrate in order to mimic those of the field-collected soil. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. A Review of the Proposed KIsi Offset-Secant Method for Size-Insensitive Linear-Elastic Fracture Toughness Evaluation

    NASA Technical Reports Server (NTRS)

    James, Mark; Wells, Doug; Allen, Phillip; Wallin, Kim

    2017-01-01

    Recently proposed modifications to ASTM E399 would provide a new size-insensitive approach to analyzing the force-displacement test record. The proposed size-insensitive linear-elastic fracture toughness, KIsi, targets a consistent 0.5mm crack extension for all specimen sizes by using an offset secant that is a function of the specimen ligament length. The KIsi evaluation also removes the Pmax/PQ criterion and increases the allowable specimen deformation. These latter two changes allow more plasticity at the crack tip, prompting the review undertaken in this work to ensure the validity of this new interpretation of the force-displacement curve. This paper provides a brief review of the proposed KIsi methodology and summarizes a finite element study into the effects of increased crack tip plasticity on the method given the allowance for additional specimen deformation. The study has two primary points of investigation: the effect of crack tip plasticity on compliance change in the force-displacement record and the continued validity of linear-elastic fracture mechanics to describe the crack front conditions. The analytical study illustrates that linear-elastic fracture mechanics assumptions remain valid at the increased deformation limit; however, the influence of plasticity on the compliance change in the test record is problematic. A proposed revision to the validity criteria for the KIsi test method is briefly discussed.

  17. 76 FR 69294 - Proposed Generic Communication Draft Generic Letter on Seismic Risk Evaluations for Operating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ... COMMISSION Proposed Generic Communication Draft Generic Letter on Seismic Risk Evaluations for Operating... public comment Draft Generic Letter 2011-XX: Seismic Risk Evaluations for Operating Reactors. The public... for public comment Draft Generic Letter 2011-XX: Seismic Risk Evaluations for Operating Reactors...

  18. 77 FR 18848 - Notice of Submission of Proposed Information Collection to OMB; Choice Neighborhoods Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... Evaluation, Phase I AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice. SUMMARY: The... grants and establishing a baseline for long-term evaluation of program outcomes. The information... lists the following information: Title of Proposal: Choice Neighborhoods Evaluation, Phase I....

  19. Evaluation of exercise-respiratory system modifications and preliminary respiratory-circulatory system integration scheme

    NASA Technical Reports Server (NTRS)

    Gallagher, R. R.

    1974-01-01

    The respiratory control system, functioning as an independent system, is presented with modifications of the exercise subroutine. These modifications illustrate an improved control of ventilation rates and arterial and compartmental gas tensions. A very elementary approach to describing the interactions of the respiratory and circulatory system is presented.

  20. Modification of integrated partial payload lifting assembly

    NASA Technical Reports Server (NTRS)

    Groah, Melodie; Haddock, Michael; Woodworth, Warren

    1986-01-01

    The Integrated Partial Payload Lifting Assembly (IPPLA) is currently used to transport and load experimental payloads into the cargo bay of the Space Shuttle. It is unable to carry the astronaut/passenger tunnel without a structural modification. The purpose of this design is to create a removalbe modification that will allow the IPPLA to lift and carry the passenger tunnel. Modifications evaluated were full-length insert beams which would extend through the existing strongback arms. These beam proposals were eliminated because of high cost and weight. Other proposals evaluated were attachments of cantilever beams to the existing strongback areas. The cantilever proposals reduced cost and weight compared to the full-length modifications. A third method evaluated was to simply make modifications to one side of the IPPLA therefore reducing the materials of the cantilever proposals by 40 percent. The design of the modification selected was completed with two channel beams jointly welded to a centered steel plate. The extension arm modification is inserted into the existing strongback channel beams and bolted into place. Two extension arms are added to one side of the IPPLA to provide the extra length needed to accommodate the passenger tunnel. The center counterbalance will then be offset about 20 inches to center gravity and therefore maintain horizontal status. The extension arm modification was selected because of minimum cost, low weight, and minimal installation time.

  1. Modification of integrated partial payload lifting assembly

    NASA Astrophysics Data System (ADS)

    Groah, Melodie; Haddock, Michael; Woodworth, Warren

    The Integrated Partial Payload Lifting Assembly (IPPLA) is currently used to transport and load experimental payloads into the cargo bay of the Space Shuttle. It is unable to carry the astronaut/passenger tunnel without a structural modification. The purpose of this design is to create a removalbe modification that will allow the IPPLA to lift and carry the passenger tunnel. Modifications evaluated were full-length insert beams which would extend through the existing strongback arms. These beam proposals were eliminated because of high cost and weight. Other proposals evaluated were attachments of cantilever beams to the existing strongback areas. The cantilever proposals reduced cost and weight compared to the full-length modifications. A third method evaluated was to simply make modifications to one side of the IPPLA therefore reducing the materials of the cantilever proposals by 40 percent. The design of the modification selected was completed with two channel beams jointly welded to a centered steel plate. The extension arm modification is inserted into the existing strongback channel beams and bolted into place. Two extension arms are added to one side of the IPPLA to provide the extra length needed to accommodate the passenger tunnel. The center counterbalance will then be offset about 20 inches to center gravity and therefore maintain horizontal status. The extension arm modification was selected because of minimum cost, low weight, and minimal installation time.

  2. Evaluation and modification of N-trimethyl chitosan chloride nanoparticles as protein carriers.

    PubMed

    Chen, Fu; Zhang, Zhi-Rong; Huang, Yuan

    2007-05-04

    N-Trimethyl chitosan chloride (TMC) nanoparticles were prepared by ionic crosslinking of TMC with tripolyphosphate (TPP). Two model proteins with different pI values, bovine serum albumin (BSA, pI=4.8) and bovine hemoglobin (BHb, pI=6.8), were used to investigate the loading and release features of the TMC nanoparticles. TMC samples with different degrees of quaternization were synthesized to evaluate its influence on the physicochemical properties and release profiles of the nanoparticles. Sodium alginate was used to modify the TMC nanoparticles to reduce burst release. The results indicated that the TMC nanoparticles had a high loading efficiency (95%) for BSA but a low one (30%) for BHb. The particle size and zeta potential were significantly affected by the BSA concentration but not by the BHb concentration. Nanoparticles of TMC with a lower degree of quaternization showed an increase in particle size, a decrease in zeta potential and a slower drug-release profile. As for the alginate-modified nanoparticles, a smaller size and lower zeta potential were observed and the burst release of BSA was reduced. These studies demonstrated that TMC nanoparticles are potential protein carriers, and that their physicochemical properties and release profile could be optimized by means of various modifications.

  3. Clinical evaluation of multimodal environmental modification (MEMO) in the management of cats with idiopathic cystitis.

    PubMed

    Buffington, C A Tony; Westropp, Jodi L; Chew, Dennis J; Bolus, Roger R

    2006-08-01

    This prospective observational study evaluated client-reported recurrence of lower urinary tract signs (LUTS) and other signs of abnormalities in cats with idiopathic cystitis after institution of multimodal environmental modification (MEMO). Forty-six client-owned indoor-housed cats with idiopathic cystitis, diagnosed based on a history of recurrent LUTS and evidence of absence of urolithiasis or bacterial urinary tract infection were studied. In addition to their usual care, clients were offered recommendations for MEMO based on a detailed environmental history. Cases were followed for 10 months by client contact to determine the effect of MEMO on LUTS and other signs. Significant (P<0.05) reductions in LUTS, fearfulness, nervousness, signs referable to the respiratory tract, and a trend (P<0.1) toward reduced aggressive behavior and signs referable to the lower intestinal tract were identified. These results suggest that MEMO is a promising adjunctive therapy for indoor-housed cats with LUTS, and should be followed up with prospective controlled clinical trials.

  4. Enzymatic modification of palmarosa essential oil: chemical analysis and olfactory evaluation of acylated products.

    PubMed

    Ramilijaona, Jade; Raynaud, Elsa; Bouhlel, Charfeddine; Sarrazin, Elise; Fernandez, Xavier; Antoniotti, Sylvain

    2013-12-01

    We have developed an enzymatic protocol to modify the composition of palmarosa essential oil by acylation of its alcohol components by three different acyl donors at various rates. The resulting modified products were characterized by qualitative and quantitative analyses by gas chromatography, and their olfactory properties were evaluated by professional perfumers. We showed that our protocol resulted in two types of modifications of the olfactory properties. The first and most obvious effect observed was the decrease of the alcohol content, with the concomitant increase of the corresponding esters, along with their fruity notes (pear, most notably). The second and less obvious effect was the expression of notes from minor components ((E)-β-ocimene, linalool, β-caryophyllene, and farnesene), originally masked by the sweet-floral-rose odor of geraniol, present in 70% in the palmarosa essential oil used, and emergence of citrus, green, spicy and clove characters in the modified products. This methodology might be considered in the future as a sustainable route to new natural ingredients for the perfumer.

  5. 77 FR 35408 - Proposed Collection; Comment Request: Process Evaluation of the Early Independence Award (EIA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request: Process Evaluation of..., and Strategic Initiatives (DPCPSI), National Institutes of Health (NIH), will publish periodic...

  6. 40 CFR 35.937-4 - Solicitation and evaluation of proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... relative importance attached to each criterion (a numerical weighted formula need not be utilized). (c) All... subpart. The grantee shall also evaluate the candidate's proposed method to accomplish the work...

  7. 40 CFR 35.937-4 - Solicitation and evaluation of proposals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Water Act § 35.937-4 Solicitation and evaluation of proposals. (a) Requests for professional services... relative importance attached to each criterion (a numerical weighted formula need not be utilized). (c) All...

  8. 40 CFR 35.937-4 - Solicitation and evaluation of proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Water Act § 35.937-4 Solicitation and evaluation of proposals. (a) Requests for professional services... relative importance attached to each criterion (a numerical weighted formula need not be utilized). (c) All...

  9. 40 CFR 35.937-4 - Solicitation and evaluation of proposals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Water Act § 35.937-4 Solicitation and evaluation of proposals. (a) Requests for professional services... relative importance attached to each criterion (a numerical weighted formula need not be utilized). (c) All...

  10. 75 FR 70949 - Proposed Information Collection for the Evaluation of the Aging Worker Initiative; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ... Employment and Training Administration Proposed Information Collection for the Evaluation of the Aging Worker Initiative; Comment Request AGENCY: Employment and Training Administration, Labor. ACTION: Notice. SUMMARY... burden conducts a preclearance consultation program to provide the general public and federal...

  11. Proposed Framework for Presenting Injury Data Using the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) Diagnosis Codes.

    PubMed

    Hedegaard, Holly; Johnson, Renee L; Warner, Margaret; Chen, Li-Hui; Annest, J Lee

    2016-01-22

    Frameworks based on the International Classification of Diseases (ICD) provide injury researchers and epidemiologists with standard approaches for presenting and analyzing injury-related mortality and morbidity data. Injury diagnosis frameworks, such as the Barell Matrix for the ICD Ninth Revision, Clinical Modification (ICD-9-CM) and the Injury Mortality Diagnosis Matrix for the ICD Tenth Revision (ICD-10), categorize ICD codes into major body region (e.g., head, chest, abdomen, or extremity) by nature-of-injury (e.g., fracture, laceration, organ injury, or vascular injury) categories. In the United States, morbidity coding transitioned from ICD-9- CM to ICD-10-CM on October 1, 2015. In preparation for the use of ICD-10-CMcoded morbidity data for injury surveillance and data analysis, the National Center for Health Statistics and the National Center for Injury Prevention and Control propose an ICD-10-CM Injury Diagnosis Matrix to provide a standard approach for categorizing injuries by body region and nature of injury. This report provides a brief description of the differences between ICD-9-CM and ICD-10-CM injury diagnosis codes, introduces the proposed framework and the methods used to create it, and provides a list of additional considerations for review and comment by researchers and subjectmatter experts in injury data and surveillance.

  12. 78 FR 48879 - Proposed Collection; 60-day Comment Request: Outcomes Evaluation of the National Cancer Institute...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ... opportunity for public comment on proposed data collection projects, National Cancer Institute (NCI), the National Institutes of Health (NIH) will publish periodic summaries of proposed projects to be submitted to... Evaluation of the National Cancer Institute (NCI) Cancer Prevention Fellowship Program (CPFP) SUMMARY: In...

  13. 78 FR 35942 - Proposed Collection; Comment Request: Palliative Care: Conversations Matter Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... publish periodic summaries of proposed projects to be submitted to the Office of Management and Budget... writing, or request more information on the proposed project, contact Ms. Adrienne Burroughs, Health...: Conversations Matter Evaluation SUMMARY: In compliance with the requirement of Section 3506(c)(2)(A) of the...

  14. 76 FR 10906 - Proposed Substances To Be Evaluated for Set 25 Toxicological Profiles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND...), Department of Health and Human Services (HHS). ACTION: Request for comments on the proposed substances to be... Environmental Medicine is soliciting public nominations from the list of proposed substances to be evaluated for...

  15. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Evaluating proposals of foreign iron, steel... proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods being...

  16. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Evaluating proposals of foreign iron, steel... proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods being...

  17. Economic evaluation: Concepts, selected studies, system costs, and a proposed program

    NASA Technical Reports Server (NTRS)

    Osterhoudt, F. H. (Principal Investigator)

    1979-01-01

    The more usual approaches to valuing crop information are reviewed and an integrated approach is recommended. Problems associated with implementation are examined. What has already been accomplished in the economic evaluation of LACIE-type information is reported including various studies of benefits. The costs of the existing and proposed systems are considered. A method and approach is proposed for further studies.

  18. A Proposal for a New Teacher Evaluation Process for the Delsea Regional School District

    ERIC Educational Resources Information Center

    Gravenor, Piera N.

    2011-01-01

    This executive position paper proposes recommendations for changes to the teacher evaluation policy and practice in the Delsea Regional School District. These recommendations are based upon best practices and evolving federal and state mandates in this area. A summarization of the current practice is provided along with proposed alternatives and…

  19. [The evaluation of oxidative modification of proteins in patients with chronic disseminated dermatosis].

    PubMed

    Kopitova, T V; Panteleyeva, G A; Dmitriyeva, O N; Kotkova, E V

    2014-02-01

    The analysis was made concerning oxidative modification of proteins of blood serum and erythrocytes in patients with chronic disseminated dermatosis. The high degree of total oxidative modification of proteins was established in patients with psoriasis and atopic dermatitis. The increase of level of oxidized derivatives of apoproteins in compound of lipoproteins of low density under psoriasis, atopic dermatitis and pemphigus was detected The increase of amount of carbonyl derivative of oligopeptids under psoriasis was revealed. In patients with resistance to applied therapy the statistically significant decrease of total oxidative modification of proteins of blood serum and erythrocytes was detected. This occurrence is possibly related to derangement of process of proteolytic destruction of proteins.

  20. Distribution of pathogens in central line-associated bloodstream infections among patients with and without neutropenia following chemotherapy: evidence for a proposed modification to the current surveillance definition.

    PubMed

    Steinberg, James P; Robichaux, Chad; Tejedor, Sheri Chernetsky; Reyes, Mary Dent; Jacob, Jesse T

    2013-02-01

    Many bloodstream infections (BSIs) occurring in patients with febrile neutropenia following cytotoxic chemotherapy are due to translocation of intestinal microbiota. However, these infections meet the National Healthcare Safety Network (NHSN) definition of central line-associated BSIs (CLABSIs). We sought to determine the differences in the microbiology of NHSN-defined CLABSIs in patients with and without neutropenia and, using these data, to propose a modification of the CLABSI definition. Retrospective review. Two large university hospitals over 18 months. All hospital-acquired BSIs occurring in patients with central venous catheters in place were classified using the NHSN CLABSI definition. Patients with postchemotherapy neutropenia (500 neutrophils/mm(3) or lower) at the time of blood culture were considered neutropenic. Pathogens overrepresented in the neutropenic group were identified to inform development of a modified CLABSI definition. Organisms that were more commonly observed in the neutropenic group compared with the nonneutropenic group included Escherichia coli (22.7% vs 2.5%; P < .001) but not other Enterobacteriaceae, Enterococcus faecium (18.2% vs 6.1%; P = .002), and streptococci (18.2% vs 0%; P < .001). Application of a modified CLABSI definition (removing BSI with enterococci, streptococci, or E. coli) excluded 33 of 66 neutropenic CLABSIs and decreased the CLABSI rate in one study hospital with large transplant and oncology populations from 2.12 to 1.79 cases per 1,000 line-days. Common gastrointestinal organisms were more common in the neutropenia group, suggesting that many BSIs meeting the NHSN criteria for CLABSI in the setting of neutropenia may represent translocation of gut organisms. These findings support modification of the NHSN CLABSI definition.

  1. A proposed framework for evaluation of support courses in a nursing curriculum.

    PubMed

    Smillie, C; Wong, J; Arklie, M

    1984-09-01

    Evaluation of nursing educational programmes has received increased attention since the early 1970s. Many evaluation models have been proposed; they are intended for evaluation of the total educational programme, but provide little evidence on the relevancy of the support courses to nursing practice. This paper describes one nursing school's experience in evaluation of a support course. The nature and sources of problems and difficulties encountered during the evaluation process are also discussed. The authors propose a framework for evaluation of support courses in a nursing curriculum. This framework is an application of the Glaser, Stufflebeam and Stake models of programme evaluation. It is designed to assist nurse educators to strive for sound curriculum decisions.

  2. Infrared thermographic evaluation of temperature modifications induced during implant site preparation with cylindrical versus conical drills.

    PubMed

    Scarano, Antonio; Piattelli, Adriano; Assenza, Bartolomeo; Carinci, Francesco; Di Donato, Luigi; Romani, Gian Luca; Merla, Arcangelo

    2011-12-01

    A few studies have investigated the influence of drilling on bone healing. Many factors have been reported to influence temperature rise during surgical preparation for implant placement: drill geometry, drilling depth, sharpness of the cutting tool, drilling speed, pressure applied to the drill, use of graduated versus one-step drilling, intermittent versus continuous drilling, and use or not of irrigation. The objective of this study was to quantify the temperature changes in cortical bone and at the apical portion of the drills during implant site preparation with a cylindrical implant drill versus a conical implant drill. Two implant drill systems were evaluated in vitro using bovine femoral cortical bone. The two implant drill systems evaluated in this study were system A (a cylindrical drill with triple twist drills) (Bone System, Milano, Italy) and system B (a conical drill with quadruple twist drills) (Bone System). Site preparation began, and the temperature of the cortical bone and at the apical portion of the drill was measured by the infrared thermography. The mean temperature produced in the cortical bone during implant preparation was 31.2 ± 0.5°C for the cylindrical drills and 29.1 ± 0.6°C for the conical drill. The mean temperature produced in the apical portion of the drill during implant site preparation was 32.1 ± 0.7°C for the cylindrical drill system and 29.6 ± 0.6°C for the conical drill. Statistically significant differences were found in the temperature measurements in the cortical bone in the two groups (p < .05). A statistically significant difference was observed for the temperature measurements in the apical portion of the drill in the two groups (p < .005). The model system used in this work was able to evaluate the temperature in the cortical bone and in the apical portion of the drills; the temperature modifications in the apical portion of the drill seemed to be correlated to the drill geometry. The results of the present

  3. NASA RECON: Course development, administration, and evaluation. A research and development proposal

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Roquemore, Leroy

    1984-01-01

    This proposal addresses the development, administration, and evaluation of a set of transportable, college-level courses to educate science and engineering students in the effective use of automated scientific and technical information storage and retrieval systems, and, in particular, in the use of the NASA RECON system. Chapter 1 presents a brief introduction. Chapter 2 identifies general and specific objectives, i.e., needs analysis, course development, course administration, and course evaluation. Chapter 3 proposes the methodology to be used in successfully accomplishing these objectives. Chapter 4 highlights expected results and product deliverables, and Chapter 5 presents the project evaluation plan to be followed. Chapter 6 is a brief overview of the institutional resources available at the proposing institutions, i.e., at the University of Southwestern Louisiana and at Southern University to support the project. Chapter 7 proposes a budget, time schedule, and management plan. Chapter 8 is a summary of the foregoing.

  4. Improving Evaluation in Nonprofit Organizations: A Study of How Evaluation Requests for Proposals Are Developed, Responded to, and Fulfilled

    ERIC Educational Resources Information Center

    Matthews, Nakia S.

    2015-01-01

    It is often necessary for nonprofit organizations (NPOs) to formulate a Request for Proposal (RFP) to procure essential contracted services. This is most common when seeking the services of an external evaluator. Since most NPOs do not have internal evaluation staff, developing an appropriate RFP can be quite challenging. With limited literature…

  5. Improving Evaluation in Nonprofit Organizations: A Study of How Evaluation Requests for Proposals Are Developed, Responded to, and Fulfilled

    ERIC Educational Resources Information Center

    Matthews, Nakia S.

    2015-01-01

    It is often necessary for nonprofit organizations (NPOs) to formulate a Request for Proposal (RFP) to procure essential contracted services. This is most common when seeking the services of an external evaluator. Since most NPOs do not have internal evaluation staff, developing an appropriate RFP can be quite challenging. With limited literature…

  6. 7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... (b) In making decisions about supporting or approving applications or proposals covered by this... 7 Agriculture 1 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of... OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications and...

  7. 75 FR 382 - Proposed Collection; Comment Request; Process Evaluation of the NIH's Roadmap Interdisciplinary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ...; Comment Request; Process Evaluation of the NIH's Roadmap Interdisciplinary Research Work Group Initiatives... be submitted to the Office of Management and Budget (OMB) for review and approval. Proposed... requests a three-year clearance for the ``Process Evaluation of the NIH Roadmap Interdisciplinary...

  8. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Early termination of research support: Evaluation... SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.123 Early termination of research support: Evaluation of applications and proposals...

  9. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Early termination of research support: Evaluation... Services GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.123 Early termination of research support: Evaluation of applications and proposals...

  10. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Early termination of research support: Evaluation... SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.123 Early termination of research support: Evaluation of applications and proposals...

  11. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Early termination of research support: Evaluation... SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.123 Early termination of research support: Evaluation of applications and proposals...

  12. Attentional Bias Modification With Serious Game Elements: Evaluating the Shots Game

    PubMed Central

    Sanchez Maceiras, Soraya; Boffo, Marilisa; Wiers, Reinout W

    2016-01-01

    Background Young adults often experiment with heavy use of alcohol, which poses severe health risks and increases the chance of developing addiction problems. In clinical patients, cognitive retraining of automatic appetitive processes, such as selective attention toward alcohol (known as “cognitive bias modification of attention,” or CBM-A), has been shown to be a promising add-on to treatment, helping to prevent relapse. Objective To prevent escalation of regular use into problematic use in youth, motivation appears to play a pivotal role. As CBM-A is often viewed as long and boring, this paper presents this training with the addition of serious game elements as a novel approach aimed at enhancing motivation to train. Methods A total of 96 heavy drinking undergraduate students carried out a regular CBM-A training, a gamified version (called “Shots”), or a placebo training version over 4 training sessions. Measures of motivation to change their behavior, motivation to train, drinking behavior, and attentional bias for alcohol were included before and after training. Results Alcohol attentional bias was reduced after training only in the regular training condition. Self-reported drinking behavior was not affected, but motivation to train decreased in all conditions, suggesting that the motivational features of the Shots game were not enough to fully counteract the tiresome nature of the training. Moreover, some of the motivational aspects decreased slightly more in the game condition, which may indicate potential detrimental effects of disappointing gamification. Conclusions Gamification is not without its risks. When the motivational value of a training task with serious game elements is less than expected by the adolescent, effects detrimental to their motivation may occur. We therefore advise caution when using gamification, as well as underscore the importance of careful scientific evaluation. PMID:27923780

  13. Attentional Bias Modification With Serious Game Elements: Evaluating the Shots Game.

    PubMed

    Boendermaker, Wouter J; Sanchez Maceiras, Soraya; Boffo, Marilisa; Wiers, Reinout W

    2016-12-06

    Young adults often experiment with heavy use of alcohol, which poses severe health risks and increases the chance of developing addiction problems. In clinical patients, cognitive retraining of automatic appetitive processes, such as selective attention toward alcohol (known as "cognitive bias modification of attention," or CBM-A), has been shown to be a promising add-on to treatment, helping to prevent relapse. To prevent escalation of regular use into problematic use in youth, motivation appears to play a pivotal role. As CBM-A is often viewed as long and boring, this paper presents this training with the addition of serious game elements as a novel approach aimed at enhancing motivation to train. A total of 96 heavy drinking undergraduate students carried out a regular CBM-A training, a gamified version (called "Shots"), or a placebo training version over 4 training sessions. Measures of motivation to change their behavior, motivation to train, drinking behavior, and attentional bias for alcohol were included before and after training. Alcohol attentional bias was reduced after training only in the regular training condition. Self-reported drinking behavior was not affected, but motivation to train decreased in all conditions, suggesting that the motivational features of the Shots game were not enough to fully counteract the tiresome nature of the training. Moreover, some of the motivational aspects decreased slightly more in the game condition, which may indicate potential detrimental effects of disappointing gamification. Gamification is not without its risks. When the motivational value of a training task with serious game elements is less than expected by the adolescent, effects detrimental to their motivation may occur. We therefore advise caution when using gamification, as well as underscore the importance of careful scientific evaluation.

  14. Towards an automated tool to evaluate the impact of the nuclear modification of the gluon density on quarkonium, D and B meson production in proton-nucleus collisions

    NASA Astrophysics Data System (ADS)

    Lansberg, Jean-Philippe; Shao, Hua-Sheng

    2017-01-01

    We propose a simple and model-independent procedure to account for the impact of the nuclear modification of the gluon density as encoded in nuclear collinear PDF sets on two-to-two partonic hard processes in proton-nucleus collisions. This applies to a good approximation to quarkonium, D and B meson production, generically referred to H. Our procedure consists in parametrising the square of the parton scattering amplitude, A_{gg → HX} and constraining it from the proton-proton data. Doing so, we have been able to compute the corresponding nuclear modification factors for J/ψ , Υ and D^0 as a function of y and P_T at √{s_NN}=5 and 8 TeV in the kinematics of the various LHC experiments in a model independent way. It is of course justified since the most important ingredient in such evaluations is the probability of each kinematical configuration. Our computations for D mesons can also be extended to B meson production. To further illustrate the potentiality of the tool, we provide - for the first time - predictions for the nuclear modification factor for η _c production in pPb collisions at the LHC.

  15. Calendar year 1994 groundwater quality report for the Bear Creek hydrogeologic regime, Y-12 Plant, Oak Ridge, Tennessee. 1994 Groundwater quality data interpretations and proposed program modifications

    SciTech Connect

    1995-10-01

    This groundwater quality report (GWQR) contains an evaluation of the groundwater quality data obtained during the 1994 calendar year (CY) at several hazardous and non-hazardous waste management facilities at the US Department of Energy (DOE) Y-12 Plant. These sites lie in Bear Creek Valley (BCV) west of the Y-12 Plant within the boundaries of the Bear Creek Hydrogeologic Regime which is one of three hydrogeologic regimes defined for the purposes of groundwater quality monitoring. The Environmental Management Department manages the groundwater monitoring activities under the auspices of the Y-12 Plant Groundwater Protection Program (GWPP). The purpose of the GWPP is to characterize the hydrogeology and to monitor groundwater quality at the Y-12 Plant and surrounding area to protect local groundwater resources. The annual GWQR for the Bear Creek Regime is completed in two parts. Part 1 consists primarily of data appendices and serves as a reference for the groundwater quality data obtained each CY. Part 2 (this report) contains an evaluation of the data with respect to regime-wide groundwater quality, summarizes the status and findings of ongoing hydrogeologic studies, describes changes in monitoring priorities, and presents planned modifications to the groundwater sampling and analysis activities.

  16. Evaluation in Cross-Cultural Contexts: Proposing a Framework for International Education and Training Project Evaluations.

    ERIC Educational Resources Information Center

    bin Yahya, Ismail; And Others

    This paper focuses on the need for increased sensitivity and responsiveness in international education and training project evaluations, particularly those in Third World countries. A conceptual-theoretical framework for designing and developing models appropriate for evaluating education and training projects in non-Western cultures is presented.…

  17. Heparin sodium compliance to the new proposed USP monograph: elucidation of a minor structural modification responsible for a process dependent 2.10 ppm NMR signal.

    PubMed

    Mourier, Pierre A J; Guichard, Olivier Y; Herman, Fréderic; Viskov, Christian

    2011-01-25

    Heparin is a highly sulfated hetero polysaccharide mixture found and extracted from mammalian tissues. It has been widely used as an anticoagulant drug during the past decades. In the new proposed USP heparin monograph, the ¹H NMR acceptance criteria to prevent contamination by over sulfated chondroitin sulfate (OSCS), or other persulfated glycosaminoglycans, specifies that no unidentified signals greater than 4% of the mean of signal height of 1 and 2 should be present in the following ranges: 0.10-2.00, 2.10-3.20, and 5.70-8.00 ppm. However, those criteria do not take into account the impact of potential structural modifications generated by the heparin manufacturing processes. In fact, starting from pig mucosa, heparin purification involves oxidizing reagents such as sodium peroxide, potassium permanganate and peracetic acid. In the present work, we demonstrate that potassium permanganate treated heparins show a small but characteristic extra signal at 2.10 ppm. Controlled heparinase I depolymerisation is used to target and excise the oligosaccharide responsible for this extra signal from the polysaccharide backbone. By using orthogonal chromatographic techniques, the fingerprint oligosaccharide was isolated and its structure elucidated. Without the identification of this structural moiety, such purified heparins may have been considered as non-compliant drug substance and not suitable for pharmaceutical use. Copyright © 2010 Elsevier B.V. All rights reserved.

  18. A prototype decision aid for evaluating and selecting R&D proposals

    SciTech Connect

    Al-Ayat, R.A.; Lamont, A.; Sicherman, A.

    1992-05-01

    This report describes a prototype decision aid which has been developed to assist the Institutional Research and Development (IR&D) Committee in selecting proposals for funding. This tool was requested to help address the following concerns about the IR&D proposal selection process: Some good proposals might be overlooked simply because no one on the Committee advocates them forcefully. The process takes a lot of time. The final portfolio of proposals selected may not maximize the long-run benefits to the Laboratory. These concerns stem from the observation that there is no formal framework for making distinctions between proposals, or weighing and comparing those distinctions. It was felt that the process could be improved by a framework that: Provides explicit descriptors that Committee members can use to evaluate and compare different features of proposals. Encourages the Committee to use a uniform, systematic scheme for evaluating the proposals. Helps the Committee focus more quickly on the issues that are truly relevant for distinguishing between proposals.

  19. Evaluation of the structural modifications induced by mitomycin C on nucleic acids.

    PubMed

    Jolles, B; Laigle, A; Liquier, J; Chinsky, L

    1993-04-01

    The interaction of poly(dG-dC).poly(dG-dC) with mitomycin C, an antitumor antibiotic, has been studied by various spectroscopic methods: circular dichroism, Fourier transform infrared resonance Raman scattering and using fluorescence emission of terbium bound to unpaired guanines as local conformation probe. The results allowed us to confirm the lack of long range modification of the DNA secondary structure upon binding. They also brought first information concerning the modification of the local structure of the nucleic acid at the level of mono- or bifunctional adducts.

  20. Calendar year 1993 groundwater quality report for the Chestnut Ridge Hydrogeologic Regime Y-12 Plant, Oak Ridge, Tennessee. 1993 Groundwater quality data interpretations and proposed program modifications

    SciTech Connect

    1994-09-01

    This groundwater quality report (GWQR) contains an evaluation of the groundwater quality data obtained during the 1993 calendar year (CY) at several hazardous and non-hazardous waste management facilities associated with the US DOE Y-12 Plant located on the DOE Oak Ridge Reservation (ORR) southeast of Oak Ridge, Tennessee. The groundwater quality data are presented in Part 1 of the GWQR submitted by Martin Marietta Energy Systems, Inc. to the Tennessee Department of Environment and Conservation (TDEC) in February 1994. Groundwater quality data evaluated in this report were obtained at several hazardous and non-hazardous waste management sites located within the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime). The Chestnut Ridge Regime encompasses a section of Chestnut Ridge south of the Y-12 Plant and is one of three hydrogeologic regimes defined for the purposes of groundwater quality monitoring at the plant. The Environmental Management Department of the Y-12 Plant Health, Safety, Environment, and Accountability Organization manages the groundwater monitoring activities in each regime as part of the Y-12 Plant Groundwater Protection Program (GWPP). The annual GWQR for the Chestnut Ridge Regime is completed in two parts. Part 1 consists primarily of data appendices and serves as a reference for the groundwater quality data obtained each CY under the lead of the Y-12 Plant GWPP. Because it contains information needed to comply with Resource Conservation and Recovery Act (RCRA) interim status assessment monitoring and reporting requirements, the Part 1 GWQR is submitted to the TDEC by the RCRA reporting deadline (March 1 of the following CY). Part 2 (this report) contains an evaluation of the data with respect to regime-wide groundwater quality, presents the findings and status of ongoing hydrogeologic studies, describes changes in monitoring priorities, and presents planned modifications to the groundwater sampling and analysis activities.

  1. Further Evaluation of the Proposed Interim Consolidation of the Nuclear Regulatory Commission.

    DTIC Science & Technology

    1981-06-24

    34 EMD-80-118, September 11, 1980. B-20352 said the relative importance of the cost advantage diminishes somewhat over time if budget constraints or...to the extent possible, the potential impacts of the proposed plan on all of the affected Federal agencies; and --evaluating the importance of NRC’s...permanent consolidation, makes the cost differential between the two options less important in selecting one of them. On the other hand, the proposed

  2. Managing proposals and evaluations of updates to medical knowledge: theory and applications.

    PubMed

    Anselma, Luca; Bottrighi, Alessio; Montani, Stefania; Terenziani, Paolo

    2013-04-01

    The process of keeping up-to-date the medical knowledge stored in relational databases is of paramount importance. Since quality and reliability of medical knowledge are essential, in many cases physicians' proposals of updates must undergo experts' evaluation before possibly becoming effective. However, until now no theoretical framework has been provided in order to cope with this phenomenon in a principled and non-ad hoc way. Indeed, such a framework is important not only in the medical domain, but in all Wikipedia-like contexts in which evaluation of update proposals is required. In this paper we propose GPVM (General Proposal Vetting Model), a general model to cope with update proposal⧹evaluation in relational databases. GPVM extends the current theory of temporal relational databases and, in particular, BCDM - Bitemporal Conceptual Data Model - "consensus" model, providing a new data model, new operations to propose and accept⧹reject updates, and new algebraic operators to query proposals. The properties of GPVM are also studied. In particular, GPVM is a consistent extension of BCDM and it is reducible to it. These properties ensure consistency with most relational temporal database frameworks, facilitating implementation on top of current frameworks and interoperability with previous approaches.

  3. Evaluation of dredged material proposed for ocean disposal from Buttermilk Channel, New York

    SciTech Connect

    Gardiner, W.W.; Barrows, E.S.; Antrim, L.D; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-08-01

    Buttermilk Channel was one of seven waterways that was sampled and evaluated for dredging and sediment disposal. Sediment samples were collected and analyses were conducted on sediment core samples. The evaluation of proposed dredged material from the channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples were analyzed for grain size, moisture content, and total organic carbon. A composite sediment samples, representing the entire area proposed for dredging, was analyzed for bulk density, polynuclear aromatic hydrocarbons, and 1,4-dichlorobenzene. Site water and elutriate were analyzed for metals, pesticides, and PCBs.

  4. Evaluation of a Cooperative Extension Curriculum in Florida: Food Modification for Special Needs

    ERIC Educational Resources Information Center

    Dahl, Wendy J.; Ford, Amanda L.; Radford, Allyson; Gal, Nancy J.

    2016-01-01

    State and national surveys of adult family care homes identified a strong need for education on texture-modified food preparation and the nutritional needs of older adults. An Extension curriculum, Food Modification for Special Needs, was developed to provide an overview of chewing and swallowing problems, food texture, pureed food preparation,…

  5. Formative Evaluation of Project "TEAM" (Teens Making Environment and Activity Modifications)

    ERIC Educational Resources Information Center

    Kramer, Jessica M.; Roemer, Kristin; Liljenquist, Kendra; Shin, Julia; Hart, Stacy

    2014-01-01

    Research documents the negative impact of physical and social environmental barriers on engagement in school, work, and the community for youth with intellectual and /or developmental disabilities (IDD). Project "TEAM" (Teens making Environment and Activity Modifications) was designed to teach youth to systematically identify…

  6. Formative Evaluation of Project "TEAM" (Teens Making Environment and Activity Modifications)

    ERIC Educational Resources Information Center

    Kramer, Jessica M.; Roemer, Kristin; Liljenquist, Kendra; Shin, Julia; Hart, Stacy

    2014-01-01

    Research documents the negative impact of physical and social environmental barriers on engagement in school, work, and the community for youth with intellectual and /or developmental disabilities (IDD). Project "TEAM" (Teens making Environment and Activity Modifications) was designed to teach youth to systematically identify…

  7. Evaluation of a Cooperative Extension Curriculum in Florida: Food Modification for Special Needs

    ERIC Educational Resources Information Center

    Dahl, Wendy J.; Ford, Amanda L.; Radford, Allyson; Gal, Nancy J.

    2016-01-01

    State and national surveys of adult family care homes identified a strong need for education on texture-modified food preparation and the nutritional needs of older adults. An Extension curriculum, Food Modification for Special Needs, was developed to provide an overview of chewing and swallowing problems, food texture, pureed food preparation,…

  8. Evaluation of surface sensible heat flux effects on the generation and modification of mesoscale circulations

    NASA Technical Reports Server (NTRS)

    Segal, M.; Pielke, R. A.; Mahrer, Y.

    1984-01-01

    Mesoscale thermal-induced circulations generated by horizontal gradients in surface characteristics as well as significant perturbations on land and sea breezes and mountain-valley winds due to substantial modifications in the thermal forcing are introduced. It is suggested that these types of mesoscale situations are generally ignored in forecasting but that they may have important implications in very short range predictions.

  9. Evaluation of heterogeneous metal-organic framework organocatalysts prepared by postsynthetic modification.

    PubMed

    Garibay, Sergio J; Wang, Zhenqiang; Cohen, Seth M

    2010-09-06

    A metal-organic framework (MOF) containing 2-amino-1,4-benzenedicarboxylate (NH(2)-BDC) as a building block is shown to undergo chemical modification with a set of cyclic anhydrides. The modification of the aluminum-based MOF known as MIL-53(Al)-NH(2) (MIL = Material Institut Lavoisier) by these reagents is demonstrated by using a variety of methods, including NMR and electrospray ionization mass spectrometry (ESI-MS), and the structural integrity of the modified MOFs has been confirmed by thermal gravimetric analysis (TGA) and powder X-ray diffraction (PXRD). Reaction with these cyclic anhydrides produces MOFs that display carboxylic acid functional groups within their pores. Furthermore, it is shown that maleic acid functionalized MIL-53(Al)-AMMal can act as a Brønsted acid catalyst and facilitate the methanolysis of several small epoxides. Experiments show that MIL-53(Al)-AMMal acts in a heterogeneous manner and is recyclable with consistent activity over at least three catalytic cycles. The findings presented here demonstrate several important features of covalent postsynthetic modification (PSM) on MOFs, including (1) facile introduction of catalytic functionality using simple organic reagents (e.g., anhydrides); (2) the ability to utilize and recycle organocatalytic MOFs; (3) control of catalytic activity through choice of functional group. The findings clearly illustrate that covalent postsynthetic modification represents a powerful means to access new MOF compounds that serve as organocatalytic materials.

  10. Evaluation of Heterogeneous Metal-Organic Framework Organocatalysts Prepared by Postsynthetic Modification

    PubMed Central

    Garibay, Sergio J.; Wang, Zhenqiang; Cohen, Seth M.

    2010-01-01

    A metal-organic framework (MOF) containing 2-amino-1,4-benzenedicarboxylate (NH2-BDC) as a building block is shown to undergo chemical modification with a set of cyclic anhydrides. The modification of the aluminum-based MOF known as MIL-53(Al)-NH2 (MIL = Matérial Institut Lavoisier) by these reagents is demonstrated by using a variety of methods, including NMR and ESI-MS, and the structural integrity of the modified MOFs has been confirmed by TGA, PXRD, and gas sorption analysis. Reaction with these cyclic anhydrides produces MOFs that display carboxylic acid functional groups within their pores. Furthermore, it is shown that maleic acid functionalized MIL-53(Al)-AMMal can act as a Brønsted acid catalyst and facilitate the methanolysis of several small epoxides. Experiments show that MIL-53(Al)-AMMal acts in a heterogeneous manner and is recyclable with consistent activity over at least three catalytic cycles. The findings presented here demonstrate several important features of covalent postsynthetic modification (PSM) on MOFs, including: 1) facile introduction of catalytic functionality using simple organic reagents (e.g. anhydrides); 2) the ability to utilize and recycle organocatalytic MOFs; 3) control of catalytic activity through choice of functional group. The findings clearly illustrate that covalent postsynthetic modification represents a powerful means to access new MOF compounds that serve as organocatalytic materials. PMID:20698561

  11. Proposal and Evaluation of Management Method for College Mechatronics Education Applying the Project Management

    NASA Astrophysics Data System (ADS)

    Ando, Yoshinobu; Eguchi, Yuya; Mizukawa, Makoto

    In this research, we proposed and evaluated a management method of college mechatronics education. We applied the project management to college mechatronics education. We practiced our management method to the seminar “Microcomputer Seminar” for 3rd grade students who belong to Department of Electrical Engineering, Shibaura Institute of Technology. We succeeded in management of Microcomputer Seminar in 2006. We obtained the good evaluation for our management method by means of questionnaire.

  12. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Evaluating proposals of foreign iron, steel... iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods being unreasonable, in...

  13. 75 FR 54295 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of SNAP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ...; ] DEPARTMENT OF AGRICULTURE Food and Nutrition Service Agency Information Collection Activities: Proposed Collection; Comment Request--Evaluation of SNAP Nutrition Education Practices Study AGENCY: Food and Nutrition Service (FNS), USDA. ACTION: Notice. SUMMARY: In accordance with the Paperwork Reduction Act of...

  14. Use of Computer Simulation in Designing and Evaluating a Proposed Rough Mill for Furniture Interior Parts

    Treesearch

    Philip A. Araman

    1977-01-01

    The design of a rough mill for the production of interior furniture parts is used to illustrate a simulation technique for analyzing and evaluating established and proposed sequential production systems. Distributions representing the real-world random characteristics of lumber, equipment feed speeds and delay times are programmed into the simulation. An example is...

  15. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Early termination of research support: Evaluation of applications and proposals. 97.123 Section 97.123 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy...

  16. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Early termination of research support: Evaluation of applications and proposals. 97.123 Section 97.123 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy...

  17. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 97.123 Section 97.123 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy...

  18. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Early termination of research support: Evaluation of applications and proposals. 97.123 Section 97.123 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy...

  19. Evaluating a Proposed Learning Experience in Terms of Eight Learning Theories.

    ERIC Educational Resources Information Center

    Abram, Marie J.

    The work of eight learning theorists was used to evaluate a proposed adult education/learning experience in an effort to operationalize a system for locating strengths and weaknesses in an instructional system prior to its implementation. Thirty-five implications for adult education were extrapolated from work representing the Behaviorist (B.F.…

  20. 77 FR 27253 - Proposed Collection, Laura Bush 21st Century Librarian Grant Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... From the Federal Register Online via the Government Publishing Office THE NATIONAL FOUNDATION FOR THE ARTS AND THE HUMANITIES Proposed Collection, Laura Bush 21st Century Librarian Grant Program Evaluation AGENCY: Institute of Museum and Library Services, National Foundation for the Arts and the...

  1. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS... directed the scientific and technical aspects of an activity has have, in the judgment of the department...

  2. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS... directed the scientific and technical aspects of an activity has have, in the judgment of the department...

  3. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS... directed the scientific and technical aspects of an activity has have, in the judgment of the department...

  4. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS... directed the scientific and technical aspects of an activity has have, in the judgment of the department...

  5. Evaluating a Proposed Learning Experience in Terms of Eight Learning Theories.

    ERIC Educational Resources Information Center

    Abram, Marie J.

    The work of eight learning theorists was used to evaluate a proposed adult education/learning experience in an effort to operationalize a system for locating strengths and weaknesses in an instructional system prior to its implementation. Thirty-five implications for adult education were extrapolated from work representing the Behaviorist (B.F.…

  6. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... shall be applied to any reproduction or abstract thereof. Any authorized restrictive notices which the... reproduction or abstract thereof and its provisions strictly complied with. Upon completion of the evaluation, it is agreed all copies of the proposal and abstracts, if any, shall be returned to the DOE office...

  7. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  8. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  9. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  10. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  11. 75 FR 16153 - Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); and November 7, 2003 (68 FR 63098), December 7, 2005 (70 FR 72840). ] Proposed Substances To Be Evaluated for Set 24... BROMODICHLOROETHANE 000683-53-4 3 1,2,3-TRICHLOROBENZ 000087-61-6 ENE. 4 POLONIUM-210....... 013981-52-7 5 LEAD-210...

  12. 43 CFR 404.22 - How will Reclamation evaluate my full proposal?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false How will Reclamation evaluate my full proposal? 404.22 Section 404.22 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Overview § 404.22 How will...

  13. Summary of the electromagnetic compatibility evaluation of the proposed satellite power system

    NASA Technical Reports Server (NTRS)

    Morrison, E. L., Jr.; Grant, W. B.; Davis, K. C.

    1980-01-01

    The effects of the proposed solar power satellite (SPS) operations on electronic equipment and systems by fundamental, harmonic, and intermodulation component emissions from the orbital station; and the fundamental, harmonic, and structural intermodulation emissions from the rectenna site were evaluated. The coupling and affects interactions affecting a wide spectrum of electronic equipment are considered. The primary EMC tasking areas are each discussed separately.

  14. 16 CFR 1028.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the protection of the rights and welfare of human subjects (whether or not the research was subject to...: Evaluation of applications and proposals. 1028.123 Section 1028.123 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL PROTECTION OF HUMAN SUBJECTS § 1028.123 Early termination of research support...

  15. 76 FR 31683 - Proposed Information Collection (NCA PreNeed Burial Evaluation) Activity: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF VETERANS AFFAIRS Proposed Information Collection (NCA PreNeed Burial Evaluation) Activity: Comment Request AGENCY... techniques or the use of other forms of information technology. Title: NCA PreNeed Burial...

  16. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  17. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  18. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  19. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  20. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  1. 77 FR 75251 - 60-Day Notice of Proposed Information Collection: Gilman Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... Notice of Proposed Information Collection: Gilman Evaluation Survey ACTION: Notice of request for public... the information collection described below. In accordance with the Paperwork Reduction Act of 1995, we...), information collection title, and the OMB control number in any correspondence. FOR FURTHER...

  2. 77 FR 66951 - Proposed Information Collection; Comment Request; BIS Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ... Bureau of Industry and Security Proposed Information Collection; Comment Request; BIS Program Evaluation... information collections, as required by the Paperwork Reduction Act of 1995. DATES: Written comments must be...., Washington, DC 20230 (or via the Internet at JJessup@doc.gov ). FOR FURTHER INFORMATION CONTACT: Requests...

  3. Proposed Amendment to Presidential Permit PP-63 and Associated Modifications to 500-kV International Transmission Line: Forbes, Minnesota to Manitoba, Canada, Northern States Power Company. Addendum to the final Environmental Assessment

    SciTech Connect

    Not Available

    1992-10-01

    This Addendum to the Final Environmental Assessment for the Proposed Amendment to Presidential Permit PP-63 and Associated Modifications to 500 kV International Transmission Line: Forbes, Minnesota to Manitoba, Canada (DOE/EA-587) addresses Northern States Power Company`s (NSP) proposed expansion of the Forbes Substation. The applicant has requested that the expansion take place on the west side of the substation, within the existing property line, instead of on the north side as originally proposed. All of the proposed construction would take place on property already owned by NSP. DOE has reviewed the environmental impacts associated with this minor modification and has determined that the conclusions reached in the environmental assessment and Finding of No Significant Impact prepared in connection with NSP`s original amendment request remain valid.

  4. Evaluation of chemically-induced pore surface modifications on rock cores.

    PubMed

    Maddinelli, G; Vitali, R

    1998-01-01

    Chemical modification of pore surface properties due to active components of crude oils could significantly affect production processes. Specific chemical treatments can prevent surface alteration, protecting pores from deposition of heavy oils components. Both relaxation times analysis and nuclear magnetic resonance (NMR) imaging technique are a valuable method for nondestructive monitoring of solid/liquid interface alteration especially if applied to heterogeneous rock cores, which are impossible to study using conventional methods (e.g., Amott tests and dynamic angle contact). In our work, we examined carbonate core plugs subjected to aging treatments in crude oil. Relaxation times measurement, revealing modifications of fluid/surface interactions and imaging, was applied in characterise heterogeneous systems and reveal fluid distribution changes. Nuclear magnetic resonance results were compared with a special microscopy technique (Cryo-SEM) that allows observation of fluids at the pore level, providing a better understanding of the processes involved.

  5. Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity

    PubMed Central

    Subba Rao, G. S. R.; Kondaiah, Paturu; Singh, Sanjay K.; Ravanan, Palaniyandi; Sporn, Michael B.

    2008-01-01

    Synthetic analogues of naturally occurring triterpenoids; glycyrrhetinic acid, arjunolic acid and boswellic acids, by modification of A-ring with a cyano- and enone- functionalities, have been reported. A novel method of synthesis of α-cyanoenones from isoxazoles is reported. Bio-assays using primary mouse macrophages and tumor cell lines indicate potent anti-inflammatory and cytotoxic activities associated with cyanoenones of boswellic acid and glycyrrhetinic acid. PMID:20622928

  6. Evaluation of protein modification during anti-viral heat bioprocessing by electrospray ionization mass spectrometry.

    PubMed

    Smales, C M; Pepper, D S; James, D C

    2001-01-01

    During the preparation of therapeutic plasma and recombinant protein biopharmaceuticals heat-treatment is routinely applied as a means of viral inactivation. However, as most proteins denature and aggregate under heat stress, it is necessary to add thermostabilizing excipients to protein formulations destined for anti-viral heat-treatment in order to prevent protein damage. Anti-viral heat-treatment bioprocessing therefore requires that a balance be found between the bioprocessing conditions, virus kill and protein integrity. In this study we have utilized a simple model protein, beta-lactoglobulin, to investigate the relationship between virucidal heat-treatment conditions (protein formulation and temperature) and the type and extent of protein modification in the liquid state. A variety of industrially relevant heat-treatments were undertaken, using formulations that included sucrose as a thermostabilizing excipient. Using liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) we show here that protein modifications do occur with increasingly harsh heat-treatment. The predominant modification under these conditions was protein glycation by either glucose or fructose derived from hydrolyzed sucrose. Advanced glycation end products and additional unidentified products were also present in beta-lactoglobulin protein samples subjected to extended heat-treatment. These findings have implications for the improvement of anti-viral heat-treatment bioprocesses to ensure the safety and efficacy of protein biopharmaceuticals. CopyrightCopyright 2001 John Wiley & Sons, Ltd.

  7. Evaluation of surface modification techniques for PWR steam generator channel heads. Final report

    SciTech Connect

    Spalaris, C.N.

    1986-06-01

    Surface modification which were developed under a previous EPRI program and then applied to Boiling Water Reactor replacement piping, were modified for treating PWR steam generator channel head surfaces. Surface modifications have been shown to reduce out-of-core activity build up in BWR and thought to be equally effective in PWR circuits as well. Prototypical surface test specimens were used to develop techniques appropriate to PWR alloy substrates which were then applied to treat the surfaces of a spare, full size PWR channel head in a field demonstration. Modified surfaces cut from test specimens and pieces removed from the field demonstration were submitted to metallurgical investigations. No damage to the substrate alloys was detected as a result of the surface modification processes. Combination of mechanical and electropolishing action improved the as fabricated finish by at least a factor of 3 for the Inconel plate and factors of 20 for the stainless weld overlay. Field demonstration yielded a factor of 10 improvement in the weld overlay and 30 to 40% in the divider plate. Because these surfaces are known to be responsible for 57% of the area radioactivity in PWR steam generators in service, prepolishing is expected to reduce radiation fields substantially. 31 figs.

  8. Proposed Framework for the Evaluation of Standalone Corpora Processing Systems: An Application to Arabic Corpora

    PubMed Central

    Al-Thubaity, Abdulmohsen; Alqifari, Reem

    2014-01-01

    Despite the accessibility of numerous online corpora, students and researchers engaged in the fields of Natural Language Processing (NLP), corpus linguistics, and language learning and teaching may encounter situations in which they need to develop their own corpora. Several commercial and free standalone corpora processing systems are available to process such corpora. In this study, we first propose a framework for the evaluation of standalone corpora processing systems and then use it to evaluate seven freely available systems. The proposed framework considers the usability, functionality, and performance of the evaluated systems while taking into consideration their suitability for Arabic corpora. While the results show that most of the evaluated systems exhibited comparable usability scores, the scores for functionality and performance were substantially different with respect to support for the Arabic language and N-grams profile generation. The results of our evaluation will help potential users of the evaluated systems to choose the system that best meets their needs. More importantly, the results will help the developers of the evaluated systems to enhance their systems and developers of new corpora processing systems by providing them with a reference framework. PMID:25610910

  9. Using a fuzzy comprehensive evaluation method to determine product usability: A proposed theoretical framework

    PubMed Central

    Zhou, Ronggang; Chan, Alan H. S.

    2016-01-01

    BACKGROUND: In order to compare existing usability data to ideal goals or to that for other products, usability practitioners have tried to develop a framework for deriving an integrated metric. However, most current usability methods with this aim rely heavily on human judgment about the various attributes of a product, but often fail to take into account of the inherent uncertainties in these judgments in the evaluation process. OBJECTIVE: This paper presents a universal method of usability evaluation by combining the analytic hierarchical process (AHP) and the fuzzy evaluation method. By integrating multiple sources of uncertain information during product usability evaluation, the method proposed here aims to derive an index that is structured hierarchically in terms of the three usability components of effectiveness, efficiency, and user satisfaction of a product. METHODS: With consideration of the theoretical basis of fuzzy evaluation, a two-layer comprehensive evaluation index was first constructed. After the membership functions were determined by an expert panel, the evaluation appraisals were computed by using the fuzzy comprehensive evaluation technique model to characterize fuzzy human judgments. Then with the use of AHP, the weights of usability components were elicited from these experts. RESULTS AND CONCLUSIONS: Compared to traditional usability evaluation methods, the major strength of the fuzzy method is that it captures the fuzziness and uncertainties in human judgments and provides an integrated framework that combines the vague judgments from multiple stages of a product evaluation process. PMID:28035943

  10. Using a fuzzy comprehensive evaluation method to determine product usability: A proposed theoretical framework.

    PubMed

    Zhou, Ronggang; Chan, Alan H S

    2017-01-01

    In order to compare existing usability data to ideal goals or to that for other products, usability practitioners have tried to develop a framework for deriving an integrated metric. However, most current usability methods with this aim rely heavily on human judgment about the various attributes of a product, but often fail to take into account of the inherent uncertainties in these judgments in the evaluation process. This paper presents a universal method of usability evaluation by combining the analytic hierarchical process (AHP) and the fuzzy evaluation method. By integrating multiple sources of uncertain information during product usability evaluation, the method proposed here aims to derive an index that is structured hierarchically in terms of the three usability components of effectiveness, efficiency, and user satisfaction of a product. With consideration of the theoretical basis of fuzzy evaluation, a two-layer comprehensive evaluation index was first constructed. After the membership functions were determined by an expert panel, the evaluation appraisals were computed by using the fuzzy comprehensive evaluation technique model to characterize fuzzy human judgments. Then with the use of AHP, the weights of usability components were elicited from these experts. Compared to traditional usability evaluation methods, the major strength of the fuzzy method is that it captures the fuzziness and uncertainties in human judgments and provides an integrated framework that combines the vague judgments from multiple stages of a product evaluation process.

  11. [Evaluation of management capacity in social organizations: an in-process methodological proposal].

    PubMed

    Guimarães, Maria do Carmo Lessa; Santos, Sandra Maria Chaves dos; Melo, Cristina; Sanches Filho, Alvino

    2004-01-01

    A bill for Public Sector Administrative Reform in Brazil introduces administrative strategies based on broad delegation of authority and "a posteriori" demands for results, thereby highlighting the issue of evaluation in public organizations. This article presents a methodological proposal to evaluate management capability in so-called social organizations, a kind of non-government public entity created within this Reform. Drafting of the bill included the definition of an underlying management concept and its dimensions, which oriented the construction of variables, indicators, parameters, and an analytical plan for evaluation. The final remarks include the argument that the conceptual choices and procedural decisions aim to produce an evaluation design that would guarantee the results' reliability and their sensitivity for approaching the phenomenon under evaluation, as well as the methodology's applicability and reproducibility in different contexts.

  12. [Proposal of a model for the evaluation of public oral health care for children].

    PubMed

    Martins, Luiz Gustavo Teixeira; de Lacerda, Josimari Telino; Nickel, Daniela Alba; Traebert, Jefferson

    2016-03-01

    This article proposes a model for quality evaluation of oral health care in children. The conceptual framework for the evaluation matrix consisted of evaluation studies on oral health care services in Brazil and other countries and a survey and review of prevailing public policies for children's health in Brazil. Two dimensions, Management and Provision, were evaluated in the quality of municipal management of pediatric oral health care. Management included two component dimensions, articulation and resources, while Provision included two more, "promotion and prevention" and "diagnosis and treatment". The evaluation matrix consisted of nine indicators in the Management dimension and nine in the Provision dimension. The indicators were elaborated in workshops with specialists. The model proved appropriate for application in municipalities with different population sizes and allows identifying the areas where managers should improve their actions.

  13. 50 CFR 218.178 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.178 Modifications to Letters of...

  14. 50 CFR 218.178 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.178 Modifications to Letters of...

  15. 50 CFR 218.178 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.178 Modifications to Letters of...

  16. 50 CFR 218.178 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.178 Modifications to Letters of...

  17. Evaluation of a proposed expert system development methodology: Two case studies

    NASA Technical Reports Server (NTRS)

    Gilstrap, Lewey

    1990-01-01

    Two expert system development projects were studied to evaluate a proposed Expert Systems Development Methodology (ESDM). The ESDM was developed to provide guidance to managers and technical personnel and serve as a standard in the development of expert systems. It was agreed that the proposed ESDM must be evaluated before it could be adopted; therefore a study was planned for its evaluation. This detailed study is now underway. Before the study began, however, two ongoing projects were selected for a retrospective evaluation. They were the Ranging Equipment Diagnostic Expert System (REDEX) and the Backup Control Mode Analysis and Utility System (BCAUS). Both projects were approximately 1 year into development. Interviews of project personnel were conducted, and the resulting data was used to prepare the retrospective evaluation. Decision models of the two projects were constructed and used to evaluate the completeness and accuracy of key provisions of ESDM. A major conclusion reached from these case studies is that suitability and risk analysis should be required for all AI projects, large and small. Further, the objectives of each stage of development during a project should be selected to reduce the next largest area of risk or uncertainty on the project.

  18. Numerical performance evaluation of design modifications on a centrifugal pump impeller running in reverse mode

    NASA Astrophysics Data System (ADS)

    Kassanos, Ioannis; Chrysovergis, Marios; Anagnostopoulos, John; Papantonis, Dimitris; Charalampopoulos, George

    2016-06-01

    In this paper the effect of impeller design variations on the performance of a centrifugal pump running as turbine is presented. Numerical simulations were performed after introducing various modifications in the design for various operating conditions. Specifically, the effects of the inlet edge shape, the meridional channel width, the number of blades and the addition of splitter blades on impeller performance was investigated. The results showed that, an increase in efficiency can be achieved by increasing the number of blades and by introducing splitter blades.

  19. Modification and Adaptation of the Program Evaluation Standards in Saudi Arabia

    ERIC Educational Resources Information Center

    Alyami, Mohammed

    2013-01-01

    The Joint Committee on Standards for Educational Evaluation's Program Evaluation Standards is probably the most recognized and applied set of evaluation standards globally. The most recent edition of The Program Evaluation Standards includes five categories and 30 standards. The five categories are Utility, Feasibility, Propriety, Accuracy, and…

  20. Modification and Adaptation of the Program Evaluation Standards in Saudi Arabia

    ERIC Educational Resources Information Center

    Alyami, Mohammed

    2013-01-01

    The Joint Committee on Standards for Educational Evaluation's Program Evaluation Standards is probably the most recognized and applied set of evaluation standards globally. The most recent edition of The Program Evaluation Standards includes five categories and 30 standards. The five categories are Utility, Feasibility, Propriety, Accuracy, and…

  1. Viscosity-Modification to Improve Remediation Efficiencies within Heterogeneous Contaminated Groundwater Aquifers: Laboratory and Field-Scale Evaluation

    NASA Astrophysics Data System (ADS)

    Silva, J. A.; Crimi, M.

    2013-12-01

    A key challenge in in situ groundwater remediation practice is achieving efficient contact between the injected remedial fluid and the target contamination in the presence of subsurface permeability heterogeneities. Even apparently small permeability contrasts can affect the delivery and subsurface distribution of injected remedial fluids, as a result of preferential flows, and reduce treatment effectiveness as a result of bypassing of contaminated media of lower permeability. Viscosity-modification is a technique that can be used to mitigate the effects of permeability heterogeneity and improve the delivery and distribution of remediation fluids during subsurface injection. Viscosity-modification involves increasing the viscosity of the injected fluid, and modifying the fluids rheological character in some cases. The increased viscosity provides a reduced fluid mobility condition within higher permeability media that, in turn, enhances the penetration of fluids into adjacent lower permeability media, improving the overall sweep efficiency within heterogeneous geomedia. Herein, we present the results of laboratory (two-dimensional flow tank) and numerical experiments that were designed to critically evaluate the utility of viscosity-modification for groundwater remediation application. Specifically, we will address the benefits and limitations of the approach and highlight the effect of system variables on the degree sweep efficiency improvement achievable. We also present the results of a recently completed Environmental Security Technology Certification Program (ESTCP) technology validation project in which viscosity-modification was applied to permanganate in situ chemical oxidation. Site selection criteria, implementation design considerations, and the long-term effects of viscosity-modified fluid treatments will be discussed.

  2. The Fear of Positive Evaluation Scale: assessing a proposed cognitive component of social anxiety.

    PubMed

    Weeks, Justin W; Heimberg, Richard G; Rodebaugh, Thomas L

    2008-01-01

    Cognitive-behavioral models propose that fear of negative evaluation is the core feature of social anxiety disorder. However, it may be that fear of evaluation in general is important in social anxiety, including fears of positive as well as negative evaluation. To test this hypothesis, we developed the Fear of Positive Evaluation Scale (FPES) and conducted analyses to examine the psychometric properties of the FPES, as well as test hypotheses regarding the construct of fear of positive evaluation (FPE). Responses from a large (n = 1711) undergraduate sample were utilized. The reliability, construct validity, and factorial validity of the FPES were examined; the distinction of FPE from fear of negative evaluation was evaluated utilizing confirmatory factor analysis; and the ability of FPE to predict social interaction anxiety above and beyond fear of negative evaluation was assessed. Results provide preliminary support for the psychometric properties of the FPES and the validity of the construct of FPE. The implications of FPE with respect to the study and treatment of social anxiety disorder are discussed.

  3. Biomechanical Evaluation of Flexor Tendon Graft With Different Repair Techniques and Graft Surface Modification

    PubMed Central

    Wu, Jingheng; Thoreson, Andrew R.; Reisdorf, Ramona L.; An, Kai-Nan; Moran, Steven L.; Amadio, Peter C.; Zhao, Chunfeng

    2016-01-01

    The purpose of this study was to investigate the biomechanical properties of modified repair techniques for flexor tendon reconstruction and the effects of surface modification using carbodiimide-derivatized synovial fluid plus gelatin (cd-SF-G), compared to the traditional repair techniques. The second and fifth digits from 16 canine forepaws were randomly divided into 4 groups: (1) traditional graft repairs (TGR group) including distal Bunnell repair and proximal Pulvertaft weave repair; (2) modified graft repairs (MGR group) including distal graft bony attachment repair and proximal step-cut repair; (3) group TGR coated with cd-SF-G (TGR-C group); and (4) group MGR coated with cd-SF-G (MGR-C group). Digit normalized work of flexion (nWOF), ultimate failure strength, and stiffness were measured. The nWOF in MGR group was significantly less than TGR group (p < 0.05). The nWOF in groups treated with cd-SF-G was significantly less than their untreated counterparts (p < 0.05). Ultimate load to failure of the MGR-C group was significantly greater than the TGR-C group (p < 0.05), but no significant difference in stiffness was found between these two groups. The modified techniques cannot only improve tendon gliding abilities but can also improve breaking strength. Additionally, surface modification with cd-SF-G significantly decreased the work of flexion. PMID:25665071

  4. Evaluation of models proposed for the 1991 revision of the International Geomagnetic Reference Field

    USGS Publications Warehouse

    Peddie, N.W.

    1992-01-01

    The 1991 revision of the International Geomagnetic Reference Field (IGRF) comprises a definitive main-field model for 1985.0, a main-field model for 1990.0, and a forecast secular-variation model for the period 1990-1995. The five 1985.0 main-field models and five 1990.0 main-field models that were proposed have been evaluated by comparing them with one another, with magnetic observatory data, and with Project MAGNET aerial survey data. The comparisons indicate that the main-field models proposed by IZMIRAN, and the secular-variation model proposed jointly by the British Geological Survey and the US Naval Oceanographic Office, should be assigned relatively lower weight in the derivation of the new IGRF models. -Author

  5. Final technical evaluation report for the proposed revised reclamation plan for the Atlas Corporation Moab Mill

    SciTech Connect

    1997-03-01

    This final Technical Evaluation Report (TER) summarizes the US Nuclear Regulatory Commission staff`s review of Atlas Corporation`s proposed reclamation plan for its uranium mill tailings pile near Moab, Utah. The proposed reclamation would allow Atlas to (1) reclaim the tailings pile for permanent disposal and long-term custodial care by a government agency in its current location on the Moab site, (2) prepare the site for closure, and (3) relinquish responsibility of the site after having its NRC license terminated. The NRC staff concludes that, subject to license conditions identified in the TER, the proposed reclamation plan meets the requirements identified in NRC regulations, which appear primarily in 10 CFR Part 40. 112 refs., 6 figs., 16 tabs.

  6. Assessment of home-based behavior modification programs for autistic children: reliability and validity of the behavioral summarized evaluation.

    PubMed

    Oneal, Brent J; Reeb, Roger N; Korte, John R; Butter, Eliot J

    2006-01-01

    Since the publication of Lovaas' (1987) impressive findings, there has been a proliferation of home-based behavior modification programs for autistic children. Parents and other paraprofessionals often play key roles in the implementation and monitoring of these programs. The Behavioral Summarized Evaluation (BSE) was developed for professionals and paraprofessionals to use in assessing the severity of autistic symptoms over the course of treatment. This paper examined the psychometric properties of the BSE (inter-item consistency, factorial composition, convergent validity, and sensitivity to parents' perceptions of symptom change over time) when used by parents of autistic youngsters undergoing home-based intervention. Recommendations for future research are presented.

  7. Proposed modifications to the RCRA post-closure permit for the Chestnut Ridge Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to several conditions of the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Chestnut Ridge Hydrogeologic Regime (CRHR) (permit number TNHW-088, EPA ID No. TN3 89 009 0001). These permit conditions define the requirements for RCRA post-closure detection groundwater monitoring at the Chestnut Ridge Sediment Disposal Basin (CRSDB) and Kerr Hollow Quarry (KHQ), and RCRA post-closure corrective action groundwater monitoring at the Chestnut Ridge Security Pits (CRSPs). Modification of these PCP conditions is requested to: (1) clarify the planned integration of RCRA post-closure corrective action groundwater monitoring at the CRSPs with the monitoring program to be established in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) record of decision (ROD), (2) revise several of the current technical requirements for groundwater monitoring based on implementation of the RCRA monitoring programs during 1996, (3) replace several of the technical procedures included in the PCP with updated versions recently issued by the Y-12 Plant Groundwater Protection Program (GWPP), and (4) correct inaccurate regulatory citations and references to permit conditions and permit attachments. With these modifications, the Y- 12 Plant will continue to meet the full intent of all regulatory obligations for post-closure care of these facilities. Section 2 provides the technical justification for each proposed permit modification. Section 3.0 contains proposed changes to Section II of the PCP. Modifications to site-specific permit conditions are presented in Section 4.0 (CRSDB), Section 5.0 (CRSPs), and Section 6.0 (KHQ). Sections 7.0 and 8.0 reference updated and revised procedures for groundwater sampling, and monitoring well plugging and abandonment, respectively. Appendix A includes all proposed revisions to the permit attachments.

  8. Evaluation of dredged material proposed for ocean disposal from Shark River Project area

    SciTech Connect

    Antrim, L.D.; Gardiner, W.W.; Barrows, E.S.; Borde, A.B.

    1996-09-01

    The objective of the Shark River Project was to evaluate proposed dredged material to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Tests and analyses were conducted on the Shark River sediments. The evaluation of proposed dredged material consisted of bulk sediment chemical and physical analysis, chemical analyses of dredging site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation tests. Individual sediment core samples collected from the Shark River were analyzed for grain size, moisture content, and total organic carbon (TOC). One sediment composite was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4- dichlorobenzene. Dredging site water and elutriate, prepared from suspended-particulate phase (SPP) of the Shark River sediment composite, were analyzed for metals, pesticides, and PCBs. Benthic acute toxicity tests and bioaccumulation tests were performed.

  9. CCRS proposal for evaluating LANDSAT-D MSS and TM data

    NASA Technical Reports Server (NTRS)

    Strome, W. M.; Cihlar, J.; Goodenough, D. G.; Guertin, F. E. (Principal Investigator); Collins, A. B.

    1983-01-01

    Accomplishments in the evaluation of LANDSAT 4 data are reported. The objectives of the Canadian proposal are: (1) to quantify the LANDSAT-4 sensors and system performance for the purpose of updating the radiometric and geometric correction algorithms for MSS and for developing and evaluating new correction algorithms to be used for TM data processing; (2) to compare and access the degree to which LANDSAT-4 MSS data can be integrated with MSS imagery acquired from earlier LANDSAT missions; and (3) to apply image analysis and information extraction techniques for specific user applications such as forestry or agriculture.

  10. Model experiments to evaluate vortex dissipation devices proposed for installation on or near aircraft runways

    NASA Technical Reports Server (NTRS)

    Kohl, R. E.

    1973-01-01

    The effectiveness of various vortex dissipation devices proposed for installation on or near aircraft runways is evaluated on basis of results of experiments conducted with a 0.03-scale model of a Boeing 747 transport aircraft in conjunction with a simulated runway. The test variables included type of vortex dissipation device, mode of operation of the powered devices, and altitude, lift coefficient and speed of the generating aircraft. A total of fifteen devices was investigated. The evaluation is based on time sequence photographs taken in the vertical and horizontal planes during each run.

  11. Waste package performance evaluations for the proposed high-level nuclear waste repository at Yucca Mountain.

    PubMed

    Mon, Kevin G; Bullard, Bryan E; Mehta, Sunil; Lee, Joon H

    2004-04-01

    The evaluation studies of the proposed repository for long-term storage of spent nuclear fuel and high-level nuclear waste at Yucca Mountain, Nevada, are underway. Fulfillment of the requirements for limiting dose to the public, which includes containment of the radioactive waste emplaced in the proposed repository and subsequent slow release of radionuclides from the Engineered Barrier System (EBS) into the geosphere, will rely on a robust waste container design, among other EBS components. Part of the evaluation process involves sensitivity studies aimed at elucidating which model parameters contribute most to the waste package and overlying drip shield degradation characteristics. The model parameters identified for this study include (1) general corrosion rate parameters and (2) stress corrosion cracking (SCC) parameters. Temperature dependence and parameter uncertainty are evaluated for the general corrosion rate model parameters while for the SCC model parameters, uncertainty treatment of stress intensity factor, crack initiation threshold, and manufacturing flaw orientations are evaluated. Based on these evaluations new uncertainty distributions are generated and recommended for future analyses. Also, early waste package failures due to improper heat treatment were added to the waste package degradation model. The results of these investigations indicate that the waste package failure profiles are governed by the manufacturing flaw orientation model parameters.

  12. A proposed systems approach to the evaluation of integrated palliative care

    PubMed Central

    2010-01-01

    Background There is increasing global interest in regional palliative care networks (PCN) to integrate care, creating systems that are more cost-effective and responsive in multi-agency settings. Networks are particularly relevant where different professional skill sets are required to serve the broad spectrum of end-of-life needs. We propose a comprehensive framework for evaluating PCNs, focusing on the nature and extent of inter-professional collaboration, community readiness, and client-centred care. Methods In the absence of an overarching structure for examining PCNs, a framework was developed based on previous models of health system evaluation, explicit theory, and the research literature relevant to PCN functioning. This research evidence was used to substantiate the choice of model factors. Results The proposed framework takes a systems approach with system structure, process of care, and patient outcomes levels of consideration. Each factor represented makes an independent contribution to the description and assessment of the network. Conclusions Realizing palliative patients' needs for complex packages of treatment and social support, in a seamless, cost-effective manner, are major drivers of the impetus for network-integrated care. The framework proposed is a first step to guide evaluation to inform the development of appropriate strategies to further promote collaboration within the PCN and, ultimately, optimal palliative care that meets patients' needs and expectations. PMID:20459734

  13. Design requirements for SRB production control system. Volume 3: Package evaluation, modification and hardware

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The software package evaluation was designed to analyze commercially available, field-proven, production control or manufacturing resource planning management technology and software package. The analysis was conducted by comparing SRB production control software requirements and conceptual system design to software package capabilities. The methodology of evaluation and the findings at each stage of evaluation are described. Topics covered include: vendor listing; request for information (RFI) document; RFI response rate and quality; RFI evaluation process; and capabilities versus requirements.

  14. Modifications to CTVS TV cameras for space shuttle compatibility and evaluation

    NASA Technical Reports Server (NTRS)

    Hoagland, K.

    1981-01-01

    Five all solid state cockpit television system (CTVS) cameras, built to USAF requirements for high performance type F-16 aircraft, were modified and tested for possible use in the closed circuit television system on the space shuttle orbiter. The 400 HZ power supply in the electronics unit assembly was replaced with two DC/DC converters to enable operation from 28VDC spacecraft-type power sources. Nonessential circuit functions were deleted to minimize input power requirements. The normal 31 mm focal length lense assemblies were replaced with wider field-of-view 19 mm focal length lenses. Base plates for and housings were redesigned to facilitate mounting and heat-sinking of the camera in the space environment and short length (14") adapter cables were designed, fabricated, and tested to meet requirements for cameras configured to mount on the astronauts helmet/visor assembly. Technical requirements, design implementation, environmental tests, Modifications prodedures, and reliability/quality efforts are discussed. Schematics are included.

  15. Comparative Proteomics for the Evaluation of Protein Expression and Modifications in Neurodegenerative Diseases.

    PubMed

    Conti, Antonio; Alessio, Massimo

    2015-01-01

    Together with hypothesis-driven approaches, high-throughput differential proteomic analysis performed primarily not only in human cerebrospinal fluid and serum but also on protein content of other tissues (blood cells, muscles, peripheral nerves, etc.) has been used in the last years to investigate neurodegenerative diseases. Even if the goal for these analyses was mainly the discovery of neurodegenerative disorders biomarkers, the characterization of specific posttranslational modifications (PTMs) and the differential protein expression resulted in being very informative to better define the pathological mechanisms. In this chapter are presented and discussed the positive aspects and challenges of the outcomes of some of our investigations on neurological and neurodegenerative disease, in order to highlight the important role of protein PTMs studies in proteomics-based approaches.

  16. Evaluation of dredged material proposed for ocean Disposal from Shoal Harbor/Compton Creek Project Area

    SciTech Connect

    Gardiner, W.W.; Borde, A.B.; Nieukirk, S.L.; Barrows, E.S.; Gruendell, B.D.; Word, J.Q.

    1996-10-01

    The objective of the Shoal Harbor/Compton Creek Project was to evaluate proposed dredged material from the Shoal harbor/Compton Creek Project Area in Belford and Monmouth, New Jersey to determine its suitability for unconfined ocean disposal at the Mud Dump Site. This was one of five waterways that the US Army Corps of Engineers- New York District requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in May 1995. The evaluation of proposed dredged material from the Shoal Harbor/Compton Creek Project area consisted of bulk chemical analyses, chemical analyses of dredging site water and elutriate, benthic and water-column acute toxicity tests and bioaccumulation studies. Eleven core samples were analyzed or grain size, moisture content, and total organic carbon. Other sediments were evaluated for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Dredging site water and elutriate water were analyzed for metals, pesticides, and PCBs.

  17. Engineering evaluation of the proposed boiler addition for Minnegasco Energy Center, Minneapolis, Minnesota. Final draft report

    SciTech Connect

    Abendroth, H.R.; Poon, A.

    1981-03-16

    The results are reported of a technical evaluation of alternate fuels for the proposed oil and natural gas fired No. 3 boiler at the Minnegasco Energy Center (MEC) located in Minneapolis, Minnesota. This report has been prepared for the Department of Energy, Office of Fuels Conversion for their use in considering an alternate fuel exemption petition submitted by MEC. The fuels considered for the proposed boiler include oil, natural gas, bituminous coal, petroleum coke/coal mixture, refuse-derived fuel (RDF), coal-oil mixtures, and coal/oil dual fuel fired. The purchase of steam from the Northern States Power Company (NSPCo) was also considered as an alternative to construction of another boiler at MEC. Evaluation of each fuel included review of the overall plant design, estimates of capital and O and M costs, salvage value, useful life, and quantities of solid waste produced. The MEC supplies steam and chilled water to the downtown Minneapolis area for building heating and cooling using two presently owned and operated 200,000 lb/h oil/natural gas fired boilers. If the proposed boiler is permitted to burn oil and natural gas, it will be identical in design to the existing boilers. The evaluation showed that the use of oil, natural gas, coal, petroleum coke-coal mixtures, coal-oil mixtures, and coal/oil dual fuel firing appear technically feasible as fuel choices for the proposed boiler. The purchase of steam from the NSPCo appears feasible as an alternative to the installation of a new boiler at the MEC. Offsite storage space would be required for receiving and storing coal, petroleum coke, or RDF Offsite fuel preparation facilities are required for preparing petroleum coke-coal mixtures and RDF.

  18. 10 CFR 501.102 - OFE evaluation of the record, decision and order for modification or rescission of a rule or order.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false OFE evaluation of the record, decision and order for... Order § 501.102 OFE evaluation of the record, decision and order for modification or rescission of a rule or order. (a) OFE will consider the entire administrative record in its evaluation of the decision...

  19. Ecological evaluation of proposed dredged material from the Point Frazer Bend Reach, Winyah Bay, South Carolina

    SciTech Connect

    Gardiner, W.W.; Ward, J.A.; Word, J.Q.

    1995-02-01

    The port of Georgetown, South Carolina, is served by navigational channels within Winyah Bay and the lower Sampit River. Dredging is required to maintain these waterways and to facilitate normal shipping traffic. Prior to dredging, ecological evaluations must be conducted to determine the suitability of the proposed dredged material for open-ocean disposal. These evaluations are to be performed under Section 103 of the Marine Protection, Research, and, Sanctuaries Act of 1972 (MPRSA), following the testing protocols presented in Evaluation of Dredged Material Proposed for Ocean Disposal Testing Manual, hereafter referred to as the 1991 Implementation Manual. The Charleston Intensive Project is a reevaluation of sediments collected from two stations (IH-2 and IH-3) in the Frazier Point Bend reach of the Winyah Bay channel. Reference sediment was also collected from site IH-R2, just south of Hare Island. The results of physical/chemical analyses indicated that some contaminants of concern were present in test treatments representing dredged material when compared with the reference treatment IH-R2. The results of this study indicate that, based on the acute toxicity and chemical analyses, dredged material represented by these test treatments is suitable for open-ocean disposal.

  20. Evaluation of indoor air quality using the decibel concept. Part I--proposal of new units.

    PubMed

    Jokl, M V

    1997-03-01

    Weber-Fechner's law concerning the perception of sound by man with time expressed as a logarithmic function can also be used for the odour constituent used in the evaluation of indoor air quality in buildings. A new unit dB (odour) based on the concentration of Total Volatile Organic Compounds (TVOC) is proposed as it is currently the basis for determining the air change rate. On the Psycho-Physical Scale according to Yaglou, the weakest odour that can be detected by the human small sensors is equal to one and corresponds to the lower limit of percentage dissatisfaction (PD) of 5.8% and a threshold concentration (TVOC) of 50 micrograms/m3-0 dB (odour). The upper limit is determined by the initial value of toxicity TVOC-25,000 micrograms/m3-135 dB (odour). Optimal values corresponding to PD = 20% (according to EUR 14449 EN) and admissible values corresponding to PD = 30% (see Table 3) are proposed, therefore the same values used to evaluate noise can be used to evaluate air quality and additionally the contribution of individual constituents (at present acoustic and odour) to the overall quality of the environment can be ascertained. The determination of the required volume of fresh air for ventilation and air-conditioning systems according to the new principles is the subject of the Part II of this paper.

  1. Evaluation of dredged material proposed for ocean disposal from Westchester Creek project area, New York

    SciTech Connect

    Pinza, M.R.; Gardiner, W.W.; Barrows, E.S.; Borde, A.B.

    1996-11-01

    The objective of the Westchester Creek project was to evaluate proposed dredged material from this area to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Westchester Creek was one of five waterways that the US Army Corps of Engineers- New York District (USACE-NYD) requested the Battelle/Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in May 1995. The evaluation of proposed dredged material from the Westchester Creek project area consisted of bulk sediment chemical analyses, chemical analyses of dredging site water and elutriate, benthic acute and water-column toxicity tests, and bioaccumulation studies. Thirteen individual sediment core samples were collected from this area and analyzed for grain size, moisture content, and total organic carbon (TOC). One composite sediment sample representing the Westchester Creek area to be dredged, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4-dichlorobenzene. Dredging site water and elutriate water, which is prepared from the suspended- particulate phase (SPP) of the Westchester Creek sediment composite, was analyzed for metals, pesticides, and PCBS.

  2. Evaluation of dredged material proposed for ocean disposal from South Brother Island Channel, New York

    SciTech Connect

    Barrows, E.S.; Gardiner, W.W.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-09-01

    South Brother Island Channel was one of seven waterways that the US Army Crops of Engineers-New York District requested the Battelle/Marine Sciences Laboratory to sample and evaluate for dredging and disposal. Tests and analyses were conducted on South Brother Island Channel sediment core samples and evaluations were performed. The evaluation of proposed dredged material from South Brother Island Channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Souther Brother Island Channel were analyzed for grain size, moisture content, and total organic carbon. a composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Site water and elutriate water, prepared from the suspended-particle phase of South Brother Island Channel sediment, were analyzed for metals, pesticides, and PCBs.

  3. A method proposal for cumulative environmental impact assessment based on the landscape vulnerability evaluation

    SciTech Connect

    Pavlickova, Katarina; Vyskupova, Monika

    2015-01-15

    Cumulative environmental impact assessment deals with the occasional use in practical application of environmental impact assessment process. The main reasons are the difficulty of cumulative impact identification caused by lack of data, inability to measure the intensity and spatial effect of all types of impacts and the uncertainty of their future evolution. This work presents a method proposal to predict cumulative impacts on the basis of landscape vulnerability evaluation. For this purpose, qualitative assessment of landscape ecological stability is conducted and major vulnerability indicators of environmental and socio-economic receptors are specified and valuated. Potential cumulative impacts and the overall impact significance are predicted quantitatively in modified Argonne multiple matrixes while considering the vulnerability of affected landscape receptors and the significance of impacts identified individually. The method was employed in the concrete environmental impact assessment process conducted in Slovakia. The results obtained in this case study reflect that this methodology is simple to apply, valid for all types of impacts and projects, inexpensive and not time-consuming. The objectivity of the partial methods used in this procedure is improved by quantitative landscape ecological stability evaluation, assignment of weights to vulnerability indicators based on the detailed characteristics of affected factors, and grading impact significance. - Highlights: • This paper suggests a method proposal for cumulative impact prediction. • The method includes landscape vulnerability evaluation. • The vulnerability of affected receptors is determined by their sensitivity. • This method can increase the objectivity of impact prediction in the EIA process.

  4. A proposed coast-wide reference monitoring system for evaluating Wetland restoration trajectories in Louisiana

    USGS Publications Warehouse

    Steyer, G.D.; Sasser, C.E.; Visser, J.M.; Swenson, E.M.; Nyman, J.A.; Raynie, R.C.

    2003-01-01

    Wetland restoration efforts conducted in Louisiana under the Coastal Wetlands Planning, Protection and Restoration Act require monitoring the effectiveness of individual projects as well as monitoring the cumulative effects of all projects in restoring, creating, enhancing, and protecting the coastal landscape. The effectiveness of the traditional paired-reference monitoring approach in Louisiana has been limited because of difficulty in finding comparable reference sites. A multiple reference approach is proposed that uses aspects of hydrogeomorphic functional assessments and probabilistic sampling. This approach includes a suite of sites that encompass the range of ecological condition for each stratum, with projects placed on a continuum of conditions found for that stratum. Trajectories in reference sites through time are then compared with project trajectories through time. Plant community zonation complicated selection of indicators, strata, and sample size. The approach proposed could serve as a model for evaluating wetland ecosystems.

  5. Evaluation of albumin structural modifications through cobalt-albumin binding (CAB) assay.

    PubMed

    Lee, Eunyoung; Eom, Ji-Eun; Jeon, Kyung-Hwa; Kim, Tae Hee; Kim, Eunnam; Jhon, Gil-Ja; Kwon, Youngjoo

    2014-03-01

    Human serum albumin (HSA) is the most abundant protein in the human body. HSA injections prepared by fractionating human blood have mainly covered the demand for albumin to treat hypoalbuminemia, the state of low concentration of albumin in blood. HSA in solution may exist in various forms such as monomers, oligomers, polymers, or as mixtures, and its conformational change and/or aggregation may occur easily. Considering these characteristics, there is a great chance of modification and polymer formation during the preparation processes of albumin products, especially injections. The albumin cobalt binding (ACB) test reported by Bar-Or et al. was originally designed to detect ischemia modified albumin (IMA), which contains the modified HSA N-terminal sequence by cleavage of the last two amino acids. In this study, we developed a cobalt albumin binding (CAB) assay to correct the flaws of the ACB test with improving the sensitivity and precision. The newly developed CAB assay easily detects albumin configuration alterations and may be able to be used in developing a quality control method for albumin and its pharmaceutical formulations including albumin injections.

  6. Evaluation of dredged material proposed for ocean disposal from Arthur Kill Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Barrows, E.S.; Borde, A.B.

    1997-01-01

    The objective of the bioassay reevaluation of Arthur Kill Federal Project was to reperform toxicity testing on proposed dredged material following current ammonia reduction protocols. Arthur Kill was one of four waterways sampled and evaluated for dredging and disposal in April 1993. Sediment samples were recollected from the Arthur Kill Project areas in August 1995. Tests and analyses were conducted according to the manual developed by the USACE and the U.S. Environmental Protection Agency (EPA), Evaluation of Dredged Material Proposed for Ocean Disposal (Testing Manual), commonly referred to as the {open_quotes}Green Book,{close_quotes} and the regional manual developed by the USACE-NYD and EPA Region II, Guidance for Performing Tests on Dredged Material to be Disposed of in Ocean Waters. The reevaluation of proposed dredged material from the Arthur Kill project areas consisted of benthic acute toxicity tests. Thirty-three individual sediment core samples were collected from the Arthur Kill project area. Three composite sediments, representing each reach of the area proposed for dredging, was used in benthic acute toxicity testing. Benthic acute toxicity tests were performed with the amphipod Ampelisca abdita and the mysid Mysidopsis bahia. The amphipod and mysid benthic toxicity test procedures followed EPA guidance for reduction of total ammonia concentrations in test systems prior to test initiation. Statistically significant acute toxicity was found in all Arthur Kill composites in the static renewal tests with A. abdita, but not in the static tests with M. bahia. Statistically significant acute toxicity and a greater than 20% increase in mortality over the reference sediment was found in the static renewal tests with A. abdita. M. bahia did not show statistically significant acute toxicity or a greater than 10% increase in mortality over reference sediment in static tests. 5 refs., 2 figs., 2 tabs.

  7. Evaluation of dredged material proposed for ocean disposal from Hackensack River Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Barrows, E.S.; Borde, A.B.

    1997-01-01

    The objective of the bioassay reevaluation of the Hackensack River Federal Project was to reperform toxicity testing on proposed dredged material with current ammonia reduction protocols. Hackensack River was one of four waterways sampled and evaluated for dredging and disposal in April 1993. Sediment samples were re-collected from the Hackensack River Project area in August 1995. Tests and analyses were conducted according to the manual developed by the USACE and the U.S. Environmental Protection Agency (EPA), Evaluation of Dredged Material Proposed for Ocean Disposal (Testing Manual), commonly referred to as the {open_quotes}Green Book,{close_quotes} and the regional manual developed by the USACE-NYD and EPA Region II, Guidance for Performing Tests on Dredged Material to be Disposed of in Ocean Waters. The reevaluation of proposed dredged material from the Hackensack River project area consisted of benthic acute toxicity tests. Thirty-three individual sediment core samples were collected from the Hackensack River project area. Three composite sediments, representing each reach of the area proposed for dredging, were used in benthic acute toxicity testing. Benthic acute toxicity tests were performed with the amphipod Ampelisca abdita and the mysid Mysidopsis bahia. The amphipod and mysid benthic toxicity test procedures followed EPA guidance for reduction of total ammonia concentrations in test systems prior to test initiation. Statistically significant acute toxicity was found in all three Hackensack River composites in the static renewal tests with A. abdita, but not in the static tests with M. bahia. Statistically significant acute toxicity and a greater than 20% increase in mortality over the reference sediment was found in the static renewal tests with A. abdita. Statistically significant mortality 10% over reference sediment was observed in the M. bahia static tests. 5 refs., 2 figs., 2 tabs.

  8. Hyperthermic tissue sealing devices: a proposed histopathologic protocol for standardizing the evaluation of thermally sealed vessels

    NASA Astrophysics Data System (ADS)

    Livengood, Ryan H.; Vos, Jeffrey A.; Coad, James E.

    2011-03-01

    Hyperthermic tissue sealing devices are advancing modern laparoscopy and other minimally invasive surgical approaches. Histopathologic evaluation of thermally sealed vessels can provide important information on their associated tissue effects and reactions. However, a standardized systematic approach has not been historically used in the literature. This paper proposes a histologic approach for the analysis of thermally sealed vessels and their basis of hemostasis, including thermal tissue changes, healing, and thrombosis. Histologic evaluation during the first week (Days 3-7) can assess the seal's primary tissue properties. These parameters include the thermal seal's length, architecture, tissue layers involved, adventitial collagen denaturation length, entrapped vapor or blood pockets, tissue homogenization and thermal tissue injury zones. While the architectural features can be assessed in Day 0-3 specimens, the latter thermal injury zones are essentially not assessable in Day 0-3 specimens. Day 14 specimens can provide information on the early healing response to the sealed vessel. Day 30 and longer specimens can be used to evaluate the seal's healing reactions. Assessment of the healing response should include seal site inflammation, granulation tissue, necrosis resorption, fibroproliferative scar healing, and thrombus organization. In order to accurately evaluate these parameters, careful specimen orientation, embedding and multiple histologic sections across the entire seal width are required. When appropriate in vivo post-treatment times are used, thermal vessel seals can be evaluated with routine light microscopy and common histologic staining methods.

  9. Evaluating Academic Scientists Collaborating in Team-Based Research: A Proposed Framework.

    PubMed

    Mazumdar, Madhu; Messinger, Shari; Finkelstein, Dianne M; Goldberg, Judith D; Lindsell, Christopher J; Morton, Sally C; Pollock, Brad H; Rahbar, Mohammad H; Welty, Leah J; Parker, Robert A

    2015-10-01

    Criteria for evaluating faculty are traditionally based on a triad of scholarship, teaching, and service. Research scholarship is often measured by first or senior authorship on peer-reviewed scientific publications and being principal investigator on extramural grants. Yet scientific innovation increasingly requires collective rather than individual creativity, which traditional measures of achievement were not designed to capture and, thus, devalue. The authors propose a simple, flexible framework for evaluating team scientists that includes both quantitative and qualitative assessments. An approach for documenting contributions of team scientists in team-based scholarship, nontraditional education, and specialized service activities is also outlined. Although biostatisticians are used for illustration, the approach is generalizable to team scientists in other disciplines.The authors offer three key recommendations to members of institutional promotion committees, department chairs, and others evaluating team scientists. First, contributions to team-based scholarship and specialized contributions to education and service need to be assessed and given appropriate and substantial weight. Second, evaluations must be founded on well-articulated criteria for assessing the stature and accomplishments of team scientists. Finally, mechanisms for collecting evaluative data must be developed and implemented at the institutional level. Without these three essentials, contributions of team scientists will continue to be undervalued in the academic environment.

  10. A pilot study evaluating a one-session attention modification training to decrease overeating in obese children

    PubMed Central

    Boutelle, Kerri N.; Kuckertz, Jennie M.; Carlson, Jordan; Amir, Nader

    2014-01-01

    There are a number of neurocognitive and behavioral mechanisms that contribute to overeating and obesity, including an attentional bias to food cues. Attention modification programs, which implicitly train attention away from specific cues, have been used in anxiety and substance abuse, and could logically be applied to food cues. The purpose of this study was to evaluate the initial efficacy of a single session attention modification training for food cues (AMP) on overeating in overweight and obese children. Twenty–four obese children who eat in the absence of hunger participated in two visits and were assigned to an attention modification program (AMP) or attentional control program (ACC). The AMP program trained attention away 100% of the time from food words to neutral words. The ACC program trained attention 50% of the time to neutral and 50% of the time to food. Outcome measures included the eating in the absence of hunger free access session, and measures of craving, liking and salivation. Results revealed significant treatment effects for EAH percent and EAH kcal (group by time interactions p < .05). Children in the ACC condition showed a significant increase over time in the number of calories consumed in the free access session (within group t=3.09, p=.009) as well as the percent of daily caloric needs consumed in free access (within group t=3.37, p=.006), whereas children in the AMP group demonstrated slight decreases in these variables (within group t=−0.75 and −0.63). There was a trend suggesting a beneficial effect of AMP as compared to ACC for attentional bias (group by time interaction p=.073). Changes in craving, liking and saliva were not significantly different between groups (ps=.178 to .527). This is the first study to demonstrate that an AMP program can influence eating in obese children. Larger studies are needed to replicate and extend these results. PMID:24512975

  11. Evaluation of AUSDRISK as a screening tool for lifestyle modification programs: international implications for policy and cost-effectiveness

    PubMed Central

    Malo, Jonathan A; Versace, Vincent L; Janus, Edward D; Laatikainen, Tiina; Peltonen, Markku; Vartiainen, Erkki; Coates, Michael J; Dunbar, James A

    2015-01-01

    Objective To evaluate the current use of Australian Type 2 Diabetes Risk Assessment Tool (AUSDRISK) as a screening tool to identify individuals at high risk of developing type 2 diabetes for entry into lifestyle modification programs. Research Design and Methods AUSDRISK scores were calculated from participants aged 40–74 years in the Greater Green Triangle Risk Factor Study, a cross-sectional population survey in 3 regions of Southwest Victoria, Australia, 2004–2006. Biomedical profiles of AUSDRISK risk categories were determined along with estimates of the Victorian population included at various cut-off scores. Sensitivity, specificity, positive predictive value (PPV), negative predictive value, and receiver operating characteristics were calculated for AUSDRISK in determining fasting plasma glucose (FPG) ≥6.1 mmol/L. Results Increasing AUSDRISK scores were associated with an increase in weight, body mass index, FPG, and metabolic syndrome. Increasing the minimum cut-off score also increased the proportion of individuals who were obese and centrally obese, had impaired fasting glucose (IFG) and metabolic syndrome. An AUSDRISK score of ≥12 was estimated to include 39.5% of the Victorian population aged 40–74 (916 000), while a score of ≥20 would include only 5.2% of the same population (120 000). At AUSDRISK≥20, the PPV for detecting FPG≥6.1 mmol/L was 28.4%. Conclusions AUSDRISK is powered to predict those with IFG and undiagnosed type 2 diabetes, but its effectiveness as the sole determinant for entry into a lifestyle modification program is questionable given the large proportion of the population screened-in using the current minimum cut-off of ≥12. AUSDRISK should be used in conjunction with oral glucose tolerance testing, fasting glucose, or glycated hemoglobin to identify those individuals at highest risk of progression to type 2 diabetes, who should be the primary targets for lifestyle modification. PMID:26468399

  12. A pilot study evaluating a one-session attention modification training to decrease overeating in obese children.

    PubMed

    Boutelle, Kerri N; Kuckertz, Jennie M; Carlson, Jordan; Amir, Nader

    2014-05-01

    There are a number of neurocognitive and behavioral mechanisms that contribute to overeating and obesity, including an attentional bias to food cues. Attention modification programs, which implicitly train attention away from specific cues, have been used in anxiety and substance abuse, and could logically be applied to food cues. The purpose of this study was to evaluate the initial efficacy of a single session attention modification training for food cues (AMP) on overeating in overweight and obese children. Twenty-four obese children who eat in the absence of hunger participated in two visits and were assigned to an attention modification program (AMP) or attentional control program (ACC). The AMP program trained attention away 100% of the time from food words to neutral words. The ACC program trained attention 50% of the time to neutral and 50% of the time to food. Outcome measures included the eating in the absence of hunger free access session, and measures of craving, liking and salivation. Results revealed significant treatment effects for EAH percent and EAH kcal (group by time interactions p<.05). Children in the ACC condition showed a significant increase over time in the number of calories consumed in the free access session (within group t=3.09, p=.009) as well as the percent of daily caloric needs consumed in free access (within group t=3.37, p=.006), whereas children in the AMP group demonstrated slight decreases in these variables (within group t=-0.75 and -0.63, respectively). There was a trend suggesting a beneficial effect of AMP as compared to ACC for attentional bias (group by time interaction p=.073). Changes in craving, liking and saliva were not significantly different between groups (ps=.178-.527). This is the first study to demonstrate that an AMP program can influence eating in obese children. Larger studies are needed to replicate and extend these results.

  13. Evaluation of dredged material proposed for ocean disposal from Eastchester Project Area, New York

    SciTech Connect

    Antrim, L.D.; Pinza, M.R.; Barrows, E.S.; Gardiner, W.W.; Tokos, J.J.S.; Gruendell, B.D.; Word, J.Q.

    1996-07-01

    The objective of the Eastchester project (Federal Project [FP] No. 6) was to evaluate proposed dredged material from the Eastchester project area in the Hutchinson River to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Eastchester was one of seven waterways that the U. S. Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle/Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in March 1994. The evaluation of proposed dredged material from the Eastchester project area consisted of bulk sediment chemical analyses, chemical analyses of dredging site water and elutriate, water- column and benthic acute toxicity tests, and bioaccumulation studies. Eighteen individual sediment core samples collected from the Eastchester project area were analyzed for grain size, moisture content, and total organic carbon (TOC). Two composite sediment samples, representing the upstream and lower reaches of the area proposed for dredging, were analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4- dichlorobenzene. Dredging site water and elutriate water, which is prepared from the suspended-particulate phase (SPP) of the two Eastchester sediment composites, were analyzed for metals, pesticides, and PCBS. An additional 1 1 composite samples were created for the USACE-New England Division (USACE-NED) using the same 18 Eastchester core samples but combined into different composites. These composites were analyzed for metals, chlorinated pesticides, PCB congeners, PAHS, and 1,4-dichlorobenzene. Water-column or SPP toxicity tests were performed along with bioaccumulation tests.

  14. Evaluation of the proposed pilot groundwater pump and treat demonstration for the Paducah Gaseous Diffusion Plant

    SciTech Connect

    Bodenstein, G.W.; Bonczek, R.R.; Early, T.O.; Hale, T.B.; Huff, D.D.; Nickelson, M.D.; Rightmire, C.T.

    1992-11-01

    This report contains the evaluation and recommendations of a Groundwater Corrective Actions Review Team. The primary goal is to evaluate the technical merit of and the need to implement a proposed groundwater pump-and-treat demonstration project for the Northwest contaminant plume at Paducah, Kentucky. A key distinction recognized by the review team is that the proposed project is intended to be a full-scale hydraulic containment of contaminants migrating from the sources of the plume, not plume remediation. The key questions incorporated into this plan are whether (1) dense, nonaqueous-phase liquids (DNAPLS) are present in the Regional Gravel Aquifer (RGA) at the source of the plume and (2) [sup 99]Tc removal must be included as part of any groundwater treatment process. The first question cannot be answered until the contaminant sources are better defined; the second question requires further risk assessment and/or a policy decision by DOE. Technical evaluation by the review team suggests that the recommended course of action be to modify the proposed work plan to include accurate identification of the sources of contaminants and vertical distribution of contaminants within the Northwest plume before a decision is made on the preferred source-control option. If DNAPLs are not present in the RGA, removal or containment of the sources is recommended. If DNAPLs are present, then hydraulic containment will be required. Finally, the review team recognizes that it is necessary to initiate a more comprehensive analysis of sitewide remediation needs to create links between action taken for the Northwest plume and action taken for other contamination sites at PGPD.

  15. 71 FR 55515 - Safety Evaluation Report for the Proposed American Centrifuge Plant in Piketon, OH, NUREG-1851...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2006-09-22

    ..., nuclear criticality safety, chemical process safety, fire safety, emergency management, environmental... COMMISSION Safety Evaluation Report for the Proposed American CentrifugePlant in Piketon, OH, NUREG-1851... Availability of Safety Evaluation Report. SUMMARY: Notice is hereby given that the Nuclear...

  16. A proposal for the curriculum and evaluation for training rural family physicians in enhanced surgical skills

    PubMed Central

    Caron, Nadine; Iglesias, Stuart; Friesen, Randall; Berjat, Vanessa; Humber, Nancy; Falk, Ryan; Prins, Mark; Haines, Victoria Vogt; Geller, Brian; Janke, Fred; Woollard, Robert; Batchelor, Bret; Van Bussel, Jared

    2015-01-01

    Summary Rural western Canada relies heavily on family physicians with enhanced surgical skills (ESS) for surgical services. The recent decision by the College of Family Physicians of Canada (CFPC) to recognize ESS as a “community of practice” section offers a potential home akin to family practice anesthesia and emergency medicine. To our knowledge, however, a skill set for ESS in Canada has never been described formally. In this paper the Curriculum Committee of the National ESS Working Group proposes a generic curriculum for the training and evaluation of the ESS skill set. PMID:26574835

  17. A Quick Method for Evaluating the Merits of a Proposed Low Sonic Boom Concept

    NASA Technical Reports Server (NTRS)

    Mack, Robert J.

    2003-01-01

    The characteristics of a proposed low-boom aircraft concept cannot be adequately assessed unless it is given an extensive, time-consuming, mission-performance, and sonic-boom analyses. So, it would be useful to have a method for performing a quick first-order sonic-boom and mission-range analysis. The evaluation method outlined in this report has the attributes of being both fast and reasonably accurate. It can also be used as a design tool to estimate the sonic-boom ground overpressures, mission range, and beginning-cruise weight of a new low-boom concept during the first stages of preliminary design.

  18. Ecological evaluation of proposed dredged material from Winyah Bay, South Carolina

    SciTech Connect

    Ward, J.A.; Gardiner, W.W.; Pinza, M.R.; Word, J.Q.

    1993-10-01

    The navigational channels of Winyah Bay, Georgetown Harbor, South Carolina require dredging to enable normal shipping traffic to use these areas. Before dredging, environmental assessments must be conducted to determine the suitability of this dredged sediment for unconfined, open-water disposal. The Charleston, South Carolina District Office of the US Army Corps of Engineers (USACE) requested that the Battelle/Marine Science Laboratory (MSL) collect sediment samples and conduct the required physical/chemical, toxicological, and bioaccumulation evaluations as required in the 1991 Implementation Manual. This report is intended to provide information required to address potential ecological effects of the Entrance Channel and Inner Harbor sediments proposed disposal in the ocean.

  19. Evaluation and Analysis of the ANSI X3T9.5 (FDDI) PMD and Proposed SMF-PMD as Influenced by Various Fiber Link Characteristics

    NASA Technical Reports Server (NTRS)

    Wernicki, M. Chris

    1991-01-01

    The purpose of this project is to evaluate the operational parameters of the Kennedy Space Center (KSC) fiber optic cable plant. The evaluation is based on the Fiber Distributed Data Interface (FDDI) Physical Medium Dependent (PMD) and Single Mode Fiber (SMF) PMD standards. From the KSC fiber profile, it would be necessary to develop the modifications needed in existing FDDI PMD and proposed SMF-PMD standards to provide for FDDI implementation and operation at KSC. This analysis should examine the major factors that influence the operating conditions of the KSC fiber plant. These factors would include, but are not limited to the number and type of connectors, attenuation and dispersion characteristics of the fiber, non-standard fiber sizes, modal bandwidth, and many other relevant or significant fiber plant characteristics that effect FDDI characteristics. This analysis is needed to gain a better understanding of overall impact that each of these factors have on FDDI performance at KSC.

  20. Evaluating Academic Scientists Collaborating in Team-Based Research: A Proposed Framework

    PubMed Central

    Mazumdar, Madhu; Messinger, Shari; Finkelstein, Dianne M.; Goldberg, Judith D.; Lindsell, Christopher J.; Morton, Sally C.; Pollock, Brad H.; Rahbar, Mohammad H.; Welty, Leah J.; Parker, Robert A.

    2015-01-01

    Criteria for evaluating faculty are traditionally based on a triad of scholarship, teaching, and service. Research scholarship is often measured by first or senior authorship on peer-reviewed scientific publications and being principal investigator on extramural grants. Yet scientific innovation increasingly requires collective rather than individual creativity, which traditional measures of achievement were not designed to capture and, thus, devalue. The authors propose a simple, flexible framework for evaluating team scientists that includes both quantitative and qualitative assessments. An approach for documenting contributions of team scientists in team-based scholarship, non-traditional education, and specialized service activities is also outlined. While biostatisticians are used for illustration, the approach is generalizable to team scientists in other disciplines. PMID:25993282

  1. [Implementation of multi-strategy programs: a proposal for an evaluation matrix].

    PubMed

    Magalhães, Rosana

    2014-07-01

    The programs that seek to achieve comprehensive changes involve the relationship between different public policies, understanding the diversity of social demands in each context and enhancing a participative dynamic. Due to the complexity of these experiences, it is important to review the traditional perspectives and discuss alternatives. Based on the analytical framework of the so-called theory-driven evaluation, the core focus of which is the analysis of the validity of the concepts that link processes and results and the exploratory case study of the qualitative character of the federal Bolsa Familia cash transfer program, the paper proposes a methodological matrix as its main result to support the evaluation of interventions related to health promotion, food security and poverty reduction.

  2. Evaluation of enamel surface modification using PS-OCT after laser treatment to increase resistance to demineralization

    NASA Astrophysics Data System (ADS)

    Kim, Jin Wan; Chan, Kenneth H.; Fried, Daniel

    2016-02-01

    At laser intensities below ablation, carbonated hydroxyapatite in enamel is converted into a purer phase hydroxyapatite with increased acid resistance. Previous studies suggested the possibility of achieving the conversion without surface modification. This study attempts to evaluate the thresholds for the modification without additional changes in physical and optical properties of the enamel. Bovine specimens were irradiated using an RF-excited CO2 laser operating at 9.4-μm with a pulse duration of 26- μs, pulse repetition rates of 100-1000 Hz, with a Gaussian spatial beam profile - 1.4 mm in diameter. After laser treatment, the samples were subjected to acid demineralization for 48 hours to simulate acidic intraoral conditions of a caries attack. The resulting demineralization and erosion were assessed using polarization sensitive OCT (PS-OCT) and 3D digital microscopy. The images from digital microscopy demonstrated a clear delineation between laser protected zones without visual changes and zones with higher levels of demineralization and erosion. Distinct changes in the surface morphology were found within the laser treated area in accordance with the Gaussian spatial beam profile. There was significant protection from the laser in areas that were not visually altered.

  3. Evaluation of enamel surface modification using PS-OCT after laser treatment to increase resistance to demineralization

    PubMed Central

    Kim, Jin Wan; Chan, Kenneth H.; Fried, Daniel

    2016-01-01

    At laser intensities below ablation, carbonated hydroxyapatite in enamel is converted into a purer phase hydroxyapatite with increased acid resistance. Previous studies suggested the possibility of achieving the conversion without surface modification. This study attempts to evaluate the thresholds for the modification without additional changes in physical and optical properties of the enamel. Bovine specimens were irradiated using an RF-excited CO2 laser operating at 9.4-µm with a pulse duration of 26-µs, pulse repetition rates of 100–1000 Hz, with a Gaussian spatial beam profile - 1.4 mm in diameter. After laser treatment, the samples were subjected to acid demineralization for 48 hours to simulate acidic intraoral conditions of a caries attack. The resulting demineralization and erosion were assessed using polarization sensitive OCT (PS-OCT) and 3D digital microscopy. The images from digital microscopy demonstrated a clear delineation between laser protected zones without visual changes and zones with higher levels of demineralization and erosion. Distinct changes in the surface morphology were found within the laser treated area in accordance with the Gaussian spatial beam profile. There was significant protection from the laser in areas that were not visually altered. PMID:27006523

  4. SDS-PAGE and IR spectroscopy to evaluate modifications in the viral protein profile induced by a cationic porphyrinic photosensitizer.

    PubMed

    Costa, Liliana; Esteves, Ana Cristina; Correia, António; Moreirinha, Catarina; Delgadillo, Ivonne; Cunha, Ângela; Neves, Maria G P S; Faustino, Maria A F; Almeida, Adelaide

    2014-12-01

    Reactive oxygen species can be responsible for microbial photodynamic inactivation due to its toxic effects, which include severe damage to proteins, lipids and nucleic acids. In this study, the photo-oxidative modifications of the proteins of a non-enveloped T4-like bacteriophage, induced by the cationic porphyrin 5,10,15-tris(1-methylpyridinium-4-yl)-20-(pentafluorophenyl)porphyrin tri-iodide were evaluated. Two methods were used: sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and infrared spectroscopy. SDS-PAGE analysis showed that the phage protein profile was considerably altered after photodynamic treatment. Seven protein bands putatively corresponding to capsid and tail tube proteins were attenuated and two other were enhanced. Infrared spectroscopy confirmed the time-dependent alteration on the phage protein profile detected by SDS-PAGE, indicative of a response to oxidative damage. Infrared analysis showed to be a promising and rapid screening approach for the analysis of the modifications induced on viral proteins by photosensitization. In fact, one single infrared spectrum can highlight the changes induced to all viral molecular structures, overcoming the delays and complex protocols of the conventional methods, in a much simple and cost effective way.

  5. Steps toward improving ethical evaluation in health technology assessment: a proposed framework.

    PubMed

    Assasi, Nazila; Tarride, Jean-Eric; O'Reilly, Daria; Schwartz, Lisa

    2016-06-06

    While evaluation of ethical aspects in health technology assessment (HTA) has gained much attention during the past years, the integration of ethics in HTA practice still presents many challenges. In response to the increasing demand for expansion of health technology assessment (HTA) methodology to include ethical issues more systematically, this article reports on a multi-stage study that aimed at construction of a framework for improving the integration of ethics in HTA. The framework was developed through the following phases: 1) a systematic review and content analysis of guidance documents for ethics in HTA; 2) identification of factors influencing the integration of ethical considerations in HTA; 3) preparation of an action-oriented framework based on the key elements of the existing guidance documents and identified barriers to and facilitators of their implementation; and 4) expert consultation and revision of the framework. The proposed framework consists of three main components: an algorithmic flowchart, which exhibits the different steps of an ethical inquiry throughout the HTA process, including: defining the objectives and scope of the evaluation, stakeholder analysis, assessing organizational capacity, framing ethical evaluation questions, ethical analysis, deliberation, and knowledge translation; a stepwise guide, which focuses on the task objectives and potential questions that are required to be addressed at each step; and a list of some commonly recommended or used tools to help facilitate the evaluation process. The proposed framework can be used to support and promote good practice in integration of ethics into HTA. However, further validation of the framework through case studies and expert consultation is required to establish its utility for HTA practice.

  6. 75 FR 65700 - 60-Day Notice of Proposed Information Collection: R/PPR Evaluation and Measurement Unit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... Notice of Proposed Information Collection: R/PPR Evaluation and Measurement Unit, Evaluation Survey... of Information Collection: R/PPR Evaluation and Measurement Unit Survey Question Bank. OMB Control... Public Diplomacy and Public Affairs' Office of Policy, Planning and Resources Evaluation and...

  7. Evaluation of dredged material proposed for ocean disposal from Bronx River Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Gardiner, W.W.; Antrim, L.D.; Pinza, M.R.; Barrows, E.S.; Borde, A.B.

    1996-12-01

    The objective of the Bronx River project was to evaluate proposed dredged material from the Bronx River project area in Bronx, New York, to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Bronx River was one of five waterways that the US Army Corps of Engineers-New York District (USAGE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and to evaluate for dredging and disposal. Sediment samples were submitted for physical and chemical analyses, chemical analyses of dredging site water and elutriate, benthic and water-column acute toxicity tests, and bioaccumulation studies. Fifteen individual sediment core samples collected from the Bronx River project area were analyzed for grain size, moisture content, and total organic carbon (TOC). One composite sediment sample, representing the entire reach of the area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4- dichlorobenzene. Dredging site water and elutriate water, which was prepared from the suspended-particulate phase (SPP) of the Bronx River sediment composite, were analyzed for metals, pesticides, and PCBS.

  8. Evaluation of dredged material proposed for ocean disposal from Hudson River, New York

    SciTech Connect

    Gardiner, W.W.; Barrows, E.S.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-09-01

    The Hudson River (Federal Project No. 41) was one of seven waterways that the U.S. Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in March 1994. Sediment samples were collected from the Hudson River. Tests and analyses were conducted on Hudson River sediment core samples. The evaluation of proposed dredged material from the Hudson River included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Hudson River were analyzed for grain size, moisture content, and total organic carbon (TOC). A composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4-dichlorobenzene. Site water and elutriate water, prepared from the suspended-particulate phase (SPP) of Hudson River sediment, were analyzed for metals, pesticides, and PCBS. Water-column or SPP toxicity tests were performed with three species. Benthic acute toxicity tests were performed. Bioaccumulation tests were also conducted.

  9. Evaluating Cloud Computing in the Proposed NASA DESDynI Ground Data System

    NASA Technical Reports Server (NTRS)

    Tran, John J.; Cinquini, Luca; Mattmann, Chris A.; Zimdars, Paul A.; Cuddy, David T.; Leung, Kon S.; Kwoun, Oh-Ig; Crichton, Dan; Freeborn, Dana

    2011-01-01

    The proposed NASA Deformation, Ecosystem Structure and Dynamics of Ice (DESDynI) mission would be a first-of-breed endeavor that would fundamentally change the paradigm by which Earth Science data systems at NASA are built. DESDynI is evaluating a distributed architecture where expert science nodes around the country all engage in some form of mission processing and data archiving. This is compared to the traditional NASA Earth Science missions where the science processing is typically centralized. What's more, DESDynI is poised to profoundly increase the amount of data collection and processing well into the 5 terabyte/day and tens of thousands of job range, both of which comprise a tremendous challenge to DESDynI's proposed distributed data system architecture. In this paper, we report on a set of architectural trade studies and benchmarks meant to inform the DESDynI mission and the broader community of the impacts of these unprecedented requirements. In particular, we evaluate the benefits of cloud computing and its integration with our existing NASA ground data system software called Apache Object Oriented Data Technology (OODT). The preliminary conclusions of our study suggest that the use of the cloud and OODT together synergistically form an effective, efficient and extensible combination that could meet the challenges of NASA science missions requiring DESDynI-like data collection and processing volumes at reduced costs.

  10. Evaluating Cloud Computing in the Proposed NASA DESDynI Ground Data System

    NASA Technical Reports Server (NTRS)

    Tran, John J.; Cinquini, Luca; Mattmann, Chris A.; Zimdars, Paul A.; Cuddy, David T.; Leung, Kon S.; Kwoun, Oh-Ig; Crichton, Dan; Freeborn, Dana

    2011-01-01

    The proposed NASA Deformation, Ecosystem Structure and Dynamics of Ice (DESDynI) mission would be a first-of-breed endeavor that would fundamentally change the paradigm by which Earth Science data systems at NASA are built. DESDynI is evaluating a distributed architecture where expert science nodes around the country all engage in some form of mission processing and data archiving. This is compared to the traditional NASA Earth Science missions where the science processing is typically centralized. What's more, DESDynI is poised to profoundly increase the amount of data collection and processing well into the 5 terabyte/day and tens of thousands of job range, both of which comprise a tremendous challenge to DESDynI's proposed distributed data system architecture. In this paper, we report on a set of architectural trade studies and benchmarks meant to inform the DESDynI mission and the broader community of the impacts of these unprecedented requirements. In particular, we evaluate the benefits of cloud computing and its integration with our existing NASA ground data system software called Apache Object Oriented Data Technology (OODT). The preliminary conclusions of our study suggest that the use of the cloud and OODT together synergistically form an effective, efficient and extensible combination that could meet the challenges of NASA science missions requiring DESDynI-like data collection and processing volumes at reduced costs.

  11. Modeling evaluation of integrated strategies to meet proposed dissolved oxygen standards for the Chicago waterway system.

    PubMed

    Melching, Charles S; Ao, Yaping; Alp, Emre

    2013-02-15

    The Chicago Waterway System (CWS) is a 113.8 km branching network of navigable waterways controlled by hydraulic structures in which the majority of flow is treated sewage effluent and there are periods of substantial combined sewer overflow. The Illinois Pollution Control Board (IPCB) designated the majority of the CWS as Secondary Contact and Indigenous Aquatic Life Use waters in the 1970s and made small alterations to these designations in 1988. Between 1988 and 2002 substantial improvements in the pollution control and water-quality management facilities were made in the Chicago area. The results of a Use Attainability Analysis led the Illinois Environmental Protection Agency (IEPA) to propose the division of the CWS into two new aquatic life use classes with appropriate dissolved oxygen (DO) standards. To aid the IPCB in their deliberations regarding the appropriate water use classifications and DO standards for the CWS, the DUFLOW model that is capable of simulating hydraulics and water-quality processes under unsteady-flow conditions was used to evaluate integrated strategies of water-quality improvement facilities that could meet the proposed DO standards during representative wet (2001) and dry (2003) years. A total of 28 new supplementary aeration stations with a maximum DO load of 80 or 100 g/s and aerated flow transfers at three locations in the CWS would be needed to achieve the IEPA proposed DO standards 100% of the time for both years. A much simpler and less costly (≈one tenth of the cost) system of facilities would be needed to meet the IEPA proposed DO standards 90% of the time. In theory, the combinations of flow augmentation and new supplemental aeration stations can achieve 100% compliance with the IEPA proposed DO standards, however, 100% compliance will be hard to achieve in practice because of-(1) difficulties in determining when to turn on the aeration stations and (2) localized heavy loads of pollutants during storms that may yield

  12. Evaluation of vegetation effects on the generation and modification of mesoscale circulations

    NASA Technical Reports Server (NTRS)

    Segal, M.; Avissar, R.; Pielke, R. A.; Mccumber, M. C.

    1988-01-01

    The effects of the presence of vegetation cover on modifying sea breeze and thermally induced upslope flows during daytime were investigated, and the possibility of the generation of mesoscale circulations due to nonuniform vegetation cover was evaluated. Scale analysis and numerical model simulations were used to provide quantitative evaluations of the circulations involved in the two vagetation effects, using several illustrative cases. The cases considered demonstrate that the impact of vegetated surfaces is highly dependent on the environmental conditions as well as vegetation characteristics.

  13. Permit application modifications

    SciTech Connect

    1995-11-01

    This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils.

  14. Design and Evaluation of Modifications to the NASA Langley Flow Impedance Tube

    NASA Technical Reports Server (NTRS)

    Jones, Michael G.; Watson, Willie R.; Parrott, Tony L.; Smith, Charles D.

    2004-01-01

    The need to minimize fan noise radiation from commercial aircraft engine nacelles continues to provide an impetus for developing new acoustic liner concepts. If the full value of such concepts is to be attained, an understanding of grazing flow effects is crucial. Because of this need for improved understanding of grazing flow effects, the NASA Langley Research Center Liner Physics Group has invested a large effort over the past decade into the development of a 2-D finite element method that characterizes wave propagation through a lined duct. The original test section in the Langley Grazing IncidenceTube was used to acquire data needed for implementation of this finite element method. This test section employed a stepper motor-driven axial-traversing bar, embedded in the wall opposite the test liner, to position a flush-mounted microphone at pre-selected locations. Complex acoustic pressure data acquired with this traversing microphone were used to educe the acoustic impedance of test liners using this 2-D finite element method and a local optimization technique. Results acquired in this facility have been extensively reported, and were compared with corresponding results from various U.S. aeroacoustics laboratories in the late 1990 s. Impedance data comparisons acquired from this multi-laboratory study suggested that it would be valuable to incorporate more realistic 3-D aeroacoustic effects into the impedance eduction methodology. This paper provides a description of modifications that have been implemented to facilitate studies of 3-D effects. The two key features of the modified test section are (1) the replacement of the traversing bar and its flush-mounted microphone with an array of 95 fixed-location microphones that are flush-mounted in all four walls of the duct, and (2) the inclusion of a suction device to modify the boundary layer upstream of the lined portion of the duct. The initial results achieved with the modified test section are provided in this

  15. 34 CFR 413.22 - What selection criteria does the Secretary use to evaluate an application proposing dissemination...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... evaluate an application proposing dissemination and training activities? 413.22 Section 413.22 Education... proposing dissemination and training activities? The Secretary uses the following selection criteria in evaluating each dissemination and training application: (a) Program factors. (20 points) The Secretary...

  16. Behavior Modification for Obesity: The Evaluation of Exercise, Contingency Management, and Program Adherence.

    ERIC Educational Resources Information Center

    And Others; Stalonas, Peter M., Jr.

    1978-01-01

    Investigated behavioral programs for obesity. Exercise and self-managed contingency components were compared using obese subjects who were evaluated after treatment and follow-up. Significant weight loss was observed at termination. The influence of exercise at follow-up was noticeable. Subjects engaged in behaviors, yet behaviors were not related…

  17. Fertility Modification Thesaurus with Focus on Evaluation of Family Planning Programs.

    ERIC Educational Resources Information Center

    Speert, Kathryn H.; Wishik, Samuel M.

    The Division of Social and Administrative Sciences of the International Institute for the Study of Human Reproduction at Columbia University has compiled this list of terms used in indexing the literature for family planning program evaluation. This thesaurus should prove of direct use to the indexer of documents describing family planning program…

  18. Synthetic Modification of 9α- and 9β-Hydroxyparthenolide by Heck or Acylation Reactions and Evaluation of Cytotoxic Activities.

    PubMed

    El Bouakher, Abderrahman; Jismy, Badr; Allouchi, Hassan; Duverger, Eric; Barkaoui, Latifa; El Hakmaoui, Ahmed; Daniellou, Richard; Guillaumet, Gérald; Akssira, Mohamed

    2016-12-05

    Motivated by the widely reported anticancer activity of parthenolides and their derivatives, a series of new substituted parthenolides was efficiently synthesized. Structural modifications were performed at the C-9 and C-13 positions of 9α- and 9β-hydroxyparthenolide, which were isolated from the aerial parts of Anvillea radiata. Twenty-one derivatives were synthesized and evaluated for their in vitro cytotoxic activity against HS-683, SK-MEL-28, A549, and MCF-7 human cancer cell lines using the MTT colorimetric assay. Among the derivatives, seven exhibited excellent activity compared to 5-fluorouracil and etoposide against the four cell lines tested, with IC50 values ranging from 1.1 to 9.4 µM.

  19. Clinical evaluation of dietary modification for treatment of spontaneous chronic kidney disease in cats.

    PubMed

    Ross, Sheri J; Osborne, Carl A; Kirk, Claudia A; Lowry, Stephen R; Koehler, Lori A; Polzin, David J

    2006-09-15

    Objective-To determine whether a renal diet modified in protein, phosphorus, sodium, and lipid content was superior to an adult maintenance diet in minimizing uremic episodes and mortality rate in cats with stage 2 or 3 chronic kidney disease (CKD). Design-Double-masked, randomized, controlled clinical trial. Animals-45 client-owned cats with spontaneous stage 2 or 3 CKD. Procedures-Cats were randomly assigned to an adult maintenance diet (n = 23 cats) or a renal diet (22) and evaluated trimonthly for up to 24 months. Efficacy of the renal diet, compared with the maintenance diet, in minimizing uremia, renal-related deaths, and all causes of death was evaluated. Results-Serum urea nitrogen concentrations were significantly lower and blood bicarbonate concentrations were significantly higher in the renal diet group at baseline and during the 12- and 24-month intervals. Significant differences were not detected in body weight; Hct; urine protein-to-creatinine ratio; and serum creatinine, potassium, calcium, and parathyroid hormone concentrations. A significantly greater percentage of cats fed the maintenance diet had uremic episodes (26%), compared with cats fed the renal diet (0%). A significant reduction in renal-related deaths but not all causes of death was detected in cats fed the renal diet. Conclusions and Clinical Relevance-The renal diet evaluated in this study was superior to an adult maintenance diet in minimizing uremic episodes and renalrelated deaths in cats with spontaneous stage 2 or 3 CKD.

  20. [Empirical standard costs for health economic evaluation in Germany -- a proposal by the working group methods in health economic evaluation].

    PubMed

    Krauth, C; Hessel, F; Hansmeier, T; Wasem, J; Seitz, R; Schweikert, B

    2005-10-01

    Measurement of health care costs is a crucial task in health economic evaluation. Various guidelines with different amount of details have been set up for costing methods in economic evaluation which, however, do not precisely stipulate how to value resource consumption. In this article we present a proposal for the standardisation of the monetary valuation of health care utilisation occurring in the follow up period after the actual intervention to be evaluated. From a societal perspective the primary direct and indirect cost components are considered, such as outpatient medical care, pharmaceuticals, non-physician health services, inpatient care, days of sick leave and early retirement due to sickness. The standard costs are based on administrative charges and rates or on official statistics. They are based on the most current data sources which are mainly from 2002 and 2003. This system of standard costs aims at an average valuation of resource consumption. This makes for the comparability of different health economic studies. Most standard costs are not based on market prices but on administratively specified charges and rates. This implies that institutional changes which are quite common in the health care system, may also affect the valuation rates, for example the introduction of DRGs. This should be taken into account when updating the system of standard costs.

  1. Supplemental Environmental Baseline Survey for Proposed Land Use Permit Modification for Expansion of the Dynamic Explosive Test Site (DETS) 9940 Main Complex Parking Lot

    SciTech Connect

    Peek, Dennis W.

    2016-10-01

    The “subject property” is comprised of a parcel of land within the Kirtland Military Reservation, Bernalillo County, New Mexico, as shown on the map in Appendix B of this document. The land requirement for the parking lot addition to the 9940 Main Complex is approximately 2.7 acres. The scope of this Supplemental Environmental Baseline Survey (SEBS) is for the parking lot addition land transfer only. For details on the original 9940 Main Complex see Environmental Baseline Survey, Land Use Permit Request for the 9940 Complex PERM/0-KI-00-0001, August 21, 2003, and for details on the 9940 Complex Expansion see Environmental Baseline Survey, Proposed Land Use Permit Expansion for 9940 DETS Complex, June 24, 2009. The 2.7-acre parcel of land for the new parking lot, which is the subject of this EBS (also referred to as the “subject property”), is adjacent to the southwest boundary of the original 12.3- acre 9940 Main Complex. No testing is known to have taken place on the subject property site. The only activity known to have taken place was the burial of overhead utility lines in 2014. Adjacent to the subject property, the 9940 Main Complex was originally a 12.3-acre site used by the Department of Energy (DOE) under a land use permit from the United States Air Force (USAF). Historical use of the site, dating from 1964, included arming, fusing, and firing of explosives and testing of explosives systems components. In the late 1970s and early 1980s experiments at the 9940 Main Complex shifted toward reactor safety issues. From 1983 to 1988, fuel coolant interaction (FCI) experiments were conducted, as were experiments with conventional high explosives (HE). Today, the land is used for training of the Nuclear Emergency Response community and for research on energetic materials. In 2009, the original complex was expanded to include four additional 20-acre areas: 9940 Training South, 9940 Training East, T-Range 6, and Training West Landing Zone. The proposed use of

  2. Mortality differentials by lifetime earnings decile: implications for evaluations of proposed Social Security law changes.

    PubMed

    Waldron, Hilary

    2013-01-01

    To evaluate the distributional effects of some proposed Social Security law changes, such as an increase in Social Security's early entitlement age, retirement policy analysts typically tabulate the number of workers who fall below a predetermined threshold of hardship. Analysts using this technique often implicitly assume that the insured population falls neatly into a low-earnings poor health group and a remaining good health group. If the hardship threshold assumption is correct, there should be no difference in mortality risk between lifetime earnings deciles above a hardship threshold. This study finds that the hardship threshold model is overwhelmingly rejected in US Social Security data, a result consistent with similar studies conducted in Canada, Germany, and England. The bottom 80-95 percent of the male lifetime earnings distribution exhibits an inverse correlation with regard to mortality risk (the higher the earnings, the lower the mortality risk) at ages 63-71.

  3. Proposal for a trigonometric method to evaluate the abduction angle of the lower limbs in neonates.

    PubMed

    Lima, Thaís; Alves, Cyntia; Funayama, Carolina A R

    2008-12-01

    It is difficult to precisely measure articular arc movement in newborns using a goniometer. This article proposes an objective method based on trigonometry for the evaluation of lower limb abduction. With the newborn aligned in the dorsal decubitus position, 2 points are marked at the level of the medial malleolus, one on the sagittal line and the other at the end of the abduction. Using the right-sided line between these 2 points and a line from the medial malleolus to the reference point at the anterior superior iliac spine or umbilical scar, an isosceles triangle is drawn, and half of the inferential abduction angle is obtained by calculating the sine. Twenty healthy full-term newborns comprise the study cohort. Intersubject and intrasubject variability among the abduction angle values (mean [SD], 37 degrees [4] degrees) is low. This method is advantageous because the measurement is precise and because the sine can be used without approximation.

  4. Visual Privacy by Context: Proposal and Evaluation of a Level-Based Visualisation Scheme

    PubMed Central

    Padilla-López, José Ramón; Chaaraoui, Alexandros Andre; Gu, Feng; Flórez-Revuelta, Francisco

    2015-01-01

    Privacy in image and video data has become an important subject since cameras are being installed in an increasing number of public and private spaces. Specifically, in assisted living, intelligent monitoring based on computer vision can allow one to provide risk detection and support services that increase people's autonomy at home. In the present work, a level-based visualisation scheme is proposed to provide visual privacy when human intervention is necessary, such as at telerehabilitation and safety assessment applications. Visualisation levels are dynamically selected based on the previously modelled context. In this way, different levels of protection can be provided, maintaining the necessary intelligibility required for the applications. Furthermore, a case study of a living room, where a top-view camera is installed, is presented. Finally, the performed survey-based evaluation indicates the degree of protection provided by the different visualisation models, as well as the personal privacy preferences and valuations of the users. PMID:26053746

  5. Visual privacy by context: proposal and evaluation of a level-based visualisation scheme.

    PubMed

    Padilla-López, José Ramón; Chaaraoui, Alexandros Andre; Gu, Feng; Flórez-Revuelta, Francisco

    2015-06-04

    Privacy in image and video data has become an important subject since cameras are being installed in an increasing number of public and private spaces. Specifically, in assisted living, intelligent monitoring based on computer vision can allow one to provide risk detection and support services that increase people's autonomy at home. In the present work, a level-based visualisation scheme is proposed to provide visual privacy when human intervention is necessary, such as at telerehabilitation and safety assessment applications. Visualisation levels are dynamically selected based on the previously modelled context. In this way, different levels of protection can be provided, maintaining the necessary intelligibility required for the applications. Furthermore, a case study of a living room, where a top-view camera is installed, is presented. Finally, the performed survey-based evaluation indicates the degree of protection provided by the different visualisation models, as well as the personal privacy preferences and valuations of the users.

  6. A proposal to evaluate mechanistic efficacy of hallucinogens in addiction treatment.

    PubMed

    Burdick, Brittany Vasae; Adinoff, Bryon

    2013-09-01

    Current treatments for addiction are frequently ineffective. Hallucinogenic therapy has been indicated as helpful for a range of substance use disorders, yet this approach remains understudied and publicly unavailable. It is nonetheless a promising treatment, which has significant, long-term beneficial effects with single doses and a profile characterized by general safety, low toxicity, and non-addictiveness. However, pharmacological interventions, such as hallucinogens, should not be offered if the same effects (e.g. psychological insights/mystical experiences) and outcomes (e.g. decreased drug use) could be achieved absent pharmacological intervention. To date, there have been no clinical comparisons of drug-induced altered states with non-drug-induced states for addiction treatment. We propose and then outline a clinical trial to address this gap in knowledge. The proposed design would evaluate abstinence outcomes in a population of prescription opioid abusers after exposure to one of three conditions: a drug-induced altered state using psilocybin, a non-drug-induced altered state via hyperventilation (Holotropic Breathwork), and an active placebo with niacin. The outcomes of such a study would reveal important differences in therapeutic potential by discriminating hallucinogen-dependent effects from those psychological effects resulting from altered states.

  7. 78 FR 77122 - Proposed Modification of a General NPDES Permit for Small Suction Dredging-Permit Number IDG-37-0000

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ..., the language of the GP contained a discrepancy with the total maximum daily load (TMDL) that was... open for public comment at this time. DATES: Interested persons may submit comments on the proposed...

  8. TATB (triaminotrinitrobenzene) purification and particle size modification: An evaluation of processing options

    SciTech Connect

    Firsich, D.W.; Thorpe, R.; Cox, L.A.

    1990-03-15

    Triaminotrinitrobenzene (TATB) is an insensitive high explosive with desirable safety characteristics. Mound is currently interested in developing a high purity, high surface area form of this compound to increase its potential applications. This paper describes recent development efforts. After setting purification and surface area goals, a number of processing procedures were tested to determine their practicality and effectiveness. The purification procedures included sulfuric acid recrystallization, dimethylsulfoxide/NaOH recrystallization, Soxhlet extraction, thermal gradient sublimation, and high-temperature recrystallization. Techniques identified for increasing surface area included crash precipitation of TATB and processing TATB in a fluid energy mill. An evaluation of the data suggested that a two- or three-step process will be necessary to produce the desired results. A sulfuric acid recrystallization used in conjunction with a high-temperature recrystallization is recommended to achieve the necessary purity. This should be followed by a crash precipitation or milling step to meet surface area requirements. 5 refs., 5 figs., 1 tab.

  9. Evaluation of several modifications of an ecometric technique for assessment of media performance.

    PubMed

    Kornacki, Jeffrey L; Gurtler, Joshua B; Yan, Zhinong; Cooper, Chad M

    2003-09-01

    Recovery of Listeria monocytogenes 101M, Jonesia denitrificans, salmonellae, and Pediococcus sp. NRRL B-2354 across nine media was evaluated with three modified versions of an ecometric method. Two approaches involved the use of broth cultures (10(8) to 10(9) CFU/ml) of individual strains and either large (10-microl) or small (1-microl) presterilized plastic loops. The third approach involved precultured slants and the inoculation of media with presterilized plastic inoculating needles (10(4) CFU per needle). Absolute growth indices (AGIs) were compared. No significant differences (P < 0.05) between methods were found when tryptic soy agar supplemented with 0.6% yeast extract (TSAYE) was used for the recovery of L. monocytogenes, J. denitrificans, Pediococcus sp. NRRL B-2354, and Salmonella spp. However, the small loop-broth technique recovered significantly fewer Salmonella enterica Typhimurium DT104 and Salmonella Senftenberg 775W cells than the other two techniques did. The performance of each individual bacterial strain on each of nine media was assayed. The recovery of L. monocytogenes was excellent (AGI > 4.8) with TSAYE, PALCAM, modified Oxford medium (MOX), and Baird-Parker agar and slight with modified PRAB (AGI = 0.4) and deMan Rogosa Sharpe (MRS) agar (< 0.1), and the organism was not recovered with the remaining media (modified lysine iron agar [MLIA], xylose lysine desoxycholate [XLD] agar, and xylose lysine tergitol 4 [XLT4] agar). The recovery of J. denitrificans with TSAYE and MOX was excellent, significantly better than that achieved with PALCAM (AGI = 3.0), but the organism was not recovered with Baird-Parker agar or with the other media tested. The recovery of Pediococcus sp. NRRL B-2354 was excellent with TSAYE and modified PRAB medium > Baird-Parker agar > acidified MRS agar, but the organism was not recovered with any of the other media tested. The best recovery of S. enterica Typhimurium DT104 was achieved with TSAYE > MLIA > or = XLD agar

  10. Parent and family impact of autism spectrum disorders: a review and proposed model for intervention evaluation.

    PubMed

    Karst, Jeffrey S; Van Hecke, Amy Vaughan

    2012-09-01

    Raising a child with an autism spectrum disorder (ASD) can be an overwhelming experience for parents and families. The pervasive and severe deficits often present in children with ASD are associated with a plethora of difficulties in caregivers, including decreased parenting efficacy, increased parenting stress, and an increase in mental and physical health problems compared with parents of both typically developing children and children with other developmental disorders. In addition to significant financial strain and time pressures, high rates of divorce and lower overall family well-being highlight the burden that having a child with an ASD can place on families. These parent and family effects reciprocally and negatively impact the diagnosed child and can even serve to diminish the positive effects of intervention. However, most interventions for ASD are evaluated only in terms of child outcomes, ignoring parent and family factors that may have an influence on both the immediate and long-term effects of therapy. It cannot be assumed that even significant improvements in the diagnosed child will ameliorate the parent and family distress already present, especially as the time and expense of intervention can add further family disruption. Thus, a new model of intervention evaluation is proposed, which incorporates these factors and better captures the transactional nature of these relationships.

  11. Pre-participation gynecological evaluation of female athletes: a new proposal

    PubMed Central

    Parmigiano, Tathiana Rebizzi; Zucchi, Eliana Viana Monteiro; de Araujo, Maíta Poli; Guindalini, Camila Santa Cruz; Castro, Rodrigo de Aquino; Bella, Zsuzsanna Ilona Katalin de Jármy Di; Girão, Manoel João Batista Castello; Cohen, Moisés; Sartori, Marair Gracio Ferreira

    2014-01-01

    Objective To propose the inclusion of a gynecological investigation during the evaluation of athletes before competitions, using a specific instrument called the Pre-participation Gynecological Examination (PPGE). Methods The study assessed 148 athletes, mean age of 15.4±2.0 years, who engaged in eight different sports modalities, and who responded to a questionnaire named Pre-Participation Gynecological Examination (PPGE), to the International Consultation on Incontinence Questionnaire - Short Form (for urinary loss), and to the Eating Attitudes Test (for eating disorders). Results Fifty percent of the participants reported irregular menstrual intervals, 23.0% did not know about sexually transmitted diseases, and 72.4% denied having, at least, an annual gynecological appointment. The study identified 18.2% who had urinary loss, and 15% presented with an increased risk of eating disorders. Moreover, 89.9% were not familiar with the occurrence of urinary incontinence in athletes and did not know that they were susceptible to the female athlete triad. A total of 87.1% of them stated that would not mention these issues to their coaches even if this would improve their health or performance. Conclusion The Pre-Participation Gynecological Examination can be considered an easy-to-apply instrument that allowed the diagnosis of alterations often underestimated by the athletes themselves. After its application, the alterations were identified, and determined the athletes’ referral to appropriate evaluation and treatment. PMID:25628197

  12. Proposal of a Nutritional Quality Index (NQI) to Evaluate the Nutritional Supplementation of Sportspeople.

    PubMed

    Palacin-Arce, Alba; Monteagudo, Celia; Beas-Jimenez, Juan de Dios; Olea-Serrano, Fatima; Mariscal-Arcas, Miguel

    2015-01-01

    Numerous supplements are used by sportspeople. They are not always appropriate for the individual or the sports activity and may do more harm than good. Vitamin and mineral supplements are unnecessary if the energy intake is sufficient to maintain body weight and derives from a diet with an adequate variety of foods. The study objectives were to evaluate the main nutrients used as supplements in sports and to propose a nutritional quality index (NQI) that enables sportspeople to optimize their use of supplements and detect and remedy possible nutritional deficits. A nutritional study was performed in 485 sportspeople recruited from Centros Andaluces de Medicina del Deporte, (CAMD). All completed socio-demographic, food frequency, and lifestyle questionnaires. The nutritional quality of their diet and need for supplementation were evaluated by scoring their dietary intake with and without supplementation, yielding two NQI scores (scales of 0-21 points) for each participant. A superior mean NQI score was obtained when the supplements taken by participants were not included (16. 28 (SD of 3.52)) than when they were included (15.47 (SD: 3.08)), attributable to an excessive intake of some nutrients through supplementation. These results indicate that sportspeople with a varied and balanced diet do not need supplements, which appear to offer no performance benefits and may pose a health risk.

  13. Proposal of a Nutritional Quality Index (NQI) to Evaluate the Nutritional Supplementation of Sportspeople

    PubMed Central

    Palacin-Arce, Alba; Monteagudo, Celia; Beas-Jimenez, Juan de Dios; Olea-Serrano, Fatima; Mariscal-Arcas, Miguel

    2015-01-01

    Background Numerous supplements are used by sportspeople. They are not always appropriate for the individual or the sports activity and may do more harm than good. Vitamin and mineral supplements are unnecessary if the energy intake is sufficient to maintain body weight and derives from a diet with an adequate variety of foods. The study objectives were to evaluate the main nutrients used as supplements in sports and to propose a nutritional quality index (NQI) that enables sportspeople to optimize their use of supplements and detect and remedy possible nutritional deficits. Material and Methods A nutritional study was performed in 485 sportspeople recruited from Centros Andaluces de Medicina del Deporte, (CAMD). All completed socio-demographic, food frequency, and lifestyle questionnaires. The nutritional quality of their diet and need for supplementation were evaluated by scoring their dietary intake with and without supplementation, yielding two NQI scores (scales of 0-21 points) for each participant. Results A superior mean NQI score was obtained when the supplements taken by participants were not included (16. 28 (SD of 3.52)) than when they were included (15.47 (SD: 3.08)), attributable to an excessive intake of some nutrients through supplementation. Conclusions These results indicate that sportspeople with a varied and balanced diet do not need supplements, which appear to offer no performance benefits and may pose a health risk. PMID:25938239

  14. Evaluation of a proposed therapeutic protocol in 12 dogs with tentative degenerative myelopathy.

    PubMed

    Polizopoulou, Zoe S; Koutinas, Alexander F; Patsikas, Michael N; Soubasis, Nektarios

    2008-09-01

    The objective of this work was to evaluate the long-term efficacy of a proposed therapeutic protocol in 12 dogs with a tentative diagnosis of degenerative myelopathy, followed-up for a 6-month period. Twelve dogs fulfilling the antemortem inclusion criteria (breed, age, adequate vaccination, history of progressive posterior ataxia and/or paraparesis, no radiographic and myelographic abnormalities in the spinal cord and vertebral column) were allocated. All these dogs presented signs of thoracolumbar syndrome (T3-L3), scored as grade I (mild to moderate ataxia and paraparesis) in 10 and grade II (severe ataxia and ambulatory paraparesis) in 2 cases. Treatment included the use of epsilon-aminocaproic acid and N-acetylcysteine, supplemented with vitamins B, C and E. Prednisolone was given for the first two weeks and upon worsening of neurological signs. Daily exercise, performed as walking or swimming, was strongly recommended. Clinicopathological evaluation was normal in all 12 dogs, and survey radiographs and myelograms did not show spinal cord compression. Magnetic resonance imaging (MRI), performed only in 4 dogs, did not disclose compressive disorders or intramedullary lesions. Neurological signs were progressively worsening in all 12 animals, eventually resulting in severe paraparesis (grade III) or paraplegia (grade IV). The applied medications do not appear to be an attractive alternative to conservative management (physiotherapy) or euthanasia in canine degenerative myelopathy, irrespective of its chronicity.

  15. Modifications of in vitro skin penetration under solar irradiation: evaluation on flow-through diffusion cells.

    PubMed

    Gélis, Christelle; Mavon, Alain; Delverdier, Maxence; Paillous, Nicole; Vicendo, Patricia

    2002-06-01

    The effect of solar irradiation on ex vivo dermatomed hairless rat skin samples maintained in culture on flow-through diffusion cells for at least 24 h was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and by histological observations. Transepidermal water loss (TEWL) measurements and kinetic analysis of the permeation of both tritiated water and 14C caffeine through the skin were performed after full-spectrum solar exposure involving the use of a xenon arc solar simulator. After a UV exposure of less than 420 mJ/cm2, skin integrity and permeation of both water and caffeine did not change significantly. In contrast, after a 420 mJ/cm2 UV exposure, the epidermis appeared more contracted, associated with an increase of 55% of TEWL and 220% of the skin permeation of tritiated water after 6 h. The data suggested a dramatic alteration of the skin barrier integrity. Moreover, the flux of 14C caffeine increased rapidly by 338% of the absorption of water 12 h after irradiation. These results reveal the presence of a threshold UV exposure that would not modify skin penetration.

  16. Evaluation and quantification of reprocessing modification in single-use devices in interventional cardiology

    NASA Astrophysics Data System (ADS)

    Tessarolo, Francesco; Ferrari, Paolo; Silvia, Bortoluzzi; Motta, Antonella; Migliaresi, Claudio; Zennaro, Lucio; Rigo, Adelio; Guarrera, Giovanni Maria; Nollo, Giandomenico

    2004-11-01

    The increasing demand in interventional cardiology urges for reprocessing of single-use-labelled medical devices. To fulfil this aim, accurate and validated regeneration protocols are mandatory to guarantee sterility, functionality and safeness. The reprocessing protocol was realized by decontamination with chloro-donors, cleaning with enzymatic solutions and hydrogen peroxide gas plasma sterilization. Reprocessing effects on ablation and electrophysiology catheters were evaluated by assessing physical-chemical changes on surfaces and bulks, as a function of the reprocessing cycles number. Conventional optical microscopy and environmental scanning electron microscopy (ESEM) underlined the presence of micro-scratches on the polyurethane shaft surface. A clear correlation was found between surface damages and number of reprocessing cycles. Atomic force microscopy (AFM) confirmed the occurrence of physical-chemical etching of the polyurethane shaft caused by the hydrogen peroxide plasma sterilization, with increasing of nano-roughness at increasing number of the reprocessing cycles. UV-Vis spectra performed on the incubation solution of polymeric shaft sample, showed an absorbance increase at about 208 nm. This fact could be attributed to the water elution from the polymer of low molecular weight oligomers. The presence of hydrolysis products of the polymeric shaft after incubation demands both the characterization of the products released in the solution and the chemical characterization of the water exposed surface.

  17. Comparative evaluation of the emulsifying properties of phosphatidylcholine after enzymatic acyl modification.

    PubMed

    Vikbjerg, Anders F; Rusig, Jean-Yves; Jonsson, Gunnar; Mu, Huiling; Xu, Xuebing

    2006-05-03

    The ability of enzymatically synthesized structured phosphatidylcholine (PC) containing caprylic acid to form and stabilize oil-in-water emulsions prepared with different triglycerides [medium chain triglycerides (MCT), soybean oil, and enzymatically synthesized structured lipids] was examined and compared with natural soybean PC and deoiled lecithin. Emulsions were prepared with varying oil and emulsifier concentrations. The particle size distribution, creaming stability, and viscosity were measured for the evaluation of the emulsifying properties. With an increase in the oil concentration, there was an increase in particle size, viscosity, and creaming layer. With an increase in the phospholipid (PL) concentration, there was usually a decrease in particle size and an increase in viscosity, where the emulsion stability was increased. General emulsions prepared with structured lipids resulted in smaller particle sizes as compared to MCT and soybean oil. Deoiled lecithin was able to increase the viscosity more significantly and give smaller particle sizes as compared to the other emulsifiers, thus producing more stable emulsions. However, in certain cases, structured PC was superior to deoiled lecithin and soybean PC. This observation was made for emulsions prepared with soybean oil or structured lipid at an oil/water ratio of 10:90. At an oil/water ratio of 30:70, the deoiled lecithin performed better as compared to the other PLs with all oil types. However, structured PC produced more stable emulsions as compared to natural soybean PC in MCT and soybean oil.

  18. Particle image velocimetry (PIV) evaluation of flow modification in aneurysm phantoms using asymmetric stents.

    PubMed

    Ionita, Ciprian N; Hoi, Y; Meng, H; Rudin, S

    2004-01-01

    Asymmetric stents are promising new devices for endovascular treatment of cerebrovascular aneurysms. For in vitro experiment a patch made of stainless steel mesh is directly attached onto a standard stent and deployed so that the patch is placed over the aneurysm orifice. Thus we modify substantially the flow into the aneurysm and decrease the shear stress on the aneurysm walls. We used mesh-patches having different permeabilities and evaluated the flow using Particle Image Velocimetry. PIV provides instantaneous velocity vector measurements in a cross-section of flow containing reflective micro-particles. A pulsed-laser light sheet illuminates the flow in the target area and images are acquired using a CCD camera. By registering the position of the particles in two successive images the fluid velocity vectors components are calculated. From the 2D velocity field a best polynomial fit is made to obtain a smooth function of each velocity with respect to the coordinates. Using the fit, we derived the values of quantities of interest in the plane of acquisition such as: tangent shear stress, vorticity and inflow. We used four meshes of different permeabilities. We found out that by using lower permeability meshes we create better conditions for the embolization of the aneurysm.

  19. Evaluation of Surface Modification as a Lunar Dust Mitigation Strategy for Thermal Control Surfaces

    NASA Technical Reports Server (NTRS)

    Gaier, James R.; Waters, Deborah L.; Misconin, Robert M.; Banks, Bruce A.; Crowder, Mark

    2011-01-01

    Three surface treatments were evaluated for their ability to lower the adhesion between lunar simulant dust and AZ93, AlFEP, and AgFEP thermal control surfaces under simulated lunar conditions. Samples were dusted in situ and exposed to a standardized puff of nitrogen gas. Thermal performance before dusting, after dusting, and after part of the dust was removed by the puff of gas, were compared to perform the assessment. None of the surface treatments was found to significantly affect the adhesion of lunar simulants to AZ93 thermal control paint. Oxygen ion beam texturing also did not lower the adhesion of lunar simulant dust to AlFEP or AgFEP. But a workfunction matching coating and a proprietary Ball Aerospace surface treatment were both found to significantly lower the adhesion of lunar simulants to AlFEP and AgFEP. Based on these results, it is recommended that all these two techniques be further explored as dust mitigation coatings for AlFEP and AgFEP thermal control surfaces.

  20. Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation.

    PubMed

    Suksamrarn, Apichart; Ponglikitmongkol, Mathurose; Wongkrajang, Kanjana; Chindaduang, Anon; Kittidanairak, Suthadta; Jankam, Aroon; Yingyongnarongkul, Boon-ek; Kittipanumat, Narin; Chokchaisiri, Ratchanaporn; Khetkam, Pichit; Piyachaturawat, Pawinee

    2008-07-15

    Three new diarylheptanoids, a 1:2 mixture of (3S)- and (3R)-1-(4-methoxyphenyl)-7-phenyl-(6E)-6-hepten-3-ol (13a and 13b) and 1-(4-hydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-one (15), together with two synthetically known diarylheptanoids 1,7-diphenyl-(1E,3E,5E)-1,3,5-triene (9) and 1-(4-hydroxyphenyl)-7-phenyl-(4E,6E)-4,6-heptadien-3-one (16), and nine known diarylheptanoids, 2, 8, 10-12, 14, a 3:1 mixture of 17a and 17b, and 18, were isolated from the rhizomes of Curcuma comosa Roxb. The absolute stereochemistry of the isolated compounds has also been determined using the modified Mosher's method. The isolated compounds and the chemically modified analogues were evaluated for their estrogenic-like transcriptional activity using RT-PCR in HeLa cell line. Some of the isolated diarylheptanoids and their modified analogues exhibited estrogenic activity comparable to or higher than that of the phytoestrogen genistein. Based on the transcriptional activation of both estrogenic targets, Bcl-xL and ERbeta gene expression, the structural features for a diarylheptanoid to exhibit high estrogenic activity are the presence of an olefinic function conjugated with the aromatic ring at the 7-position, a keto group at the 3-position, and a phenolic hydroxyl group at the p-position of the aromatic ring attached to the 1-position of the heptyl chain.

  1. Synthesis, Modification, and Characterization of Spherical SBA-15 Ordered Mesoporous Silica and Evaluation in High Performance Liquid Chromatography

    NASA Astrophysics Data System (ADS)

    Giaquinto, Alexander Paul

    SBA-15 mesoporous silica is characterized by hexagonally ordered non-intersecting parallel pores. In stark contrast, silica gel, commonly utilized in high performance liquid chromatography as a stationary phase, consists of many interconnected channels created by the spaces between primary particles. There has been much research regarding the importance of the geometry and characteristics of porous silica in chromatography, however, since the advent of ordered materials in the early 1990's, most of the investigations into use of ordered material have failed to extensively study the effects of the highly ordered porous structure on retention mechanisms. In this study, we attempt to evaluate the effect of the characteristic parallel non-intersecting pores of SBA-15 on the thermodynamics and kinetics aspects of retention. To achieve our goal, it was necessary to transform the native rope-like morphology of SBA-15 into the more commonly used and efficient sphere. The effects of temperature and synthesis time were evaluated. Following modification, characterization by low temperature nitrogen adsorption, thermogravimetric analysis and optical microscopy were utilized to evaluate pore structure, bonded layer characteristics and morphology. Suitable spherical SBA-15 packed into stainless steel columns were fully characterized for void volume and interparticle volume. Based on the results produced by kinetic studies, the evidence of column obstruction showed a reduced value for the diffusion of benzene as compared to commercial silicas, while surface specific retention studies resulted in the evaluation of reduced accessible surfaces. The obstruction of the pore volume, thus limiting the surface area, is most likely attributed to a combined effect of long narrow pores, which in the spherical particles, tend to bend or twist, and to which an uneven modified layer creates instances of pore blockage of the mobile phase.

  2. Evaluation of materials proposed for the construction of the Plasma Electrode Pockels Cell (PEPC) on beamlet

    NASA Astrophysics Data System (ADS)

    Roberts, D.; Robb, C.; Deyoreo, J.; Atherton, J.

    1992-11-01

    The proposed upgrade of the NOVA laser system at Lawrence Livermore National Laboratory employs a multipass architecture that requires an optical switch to emit the laser light at the appropriate fluence. This Pockels cell-based optical switch does not use traditional ring or thin-film electrodes because of the large aperture and high fluence of the laser system. Rather, it uses a plasma electrode Pockels cell with a KD*P crystal as the electro-optical medium. A discharge plasma is formed on each side of the electro-optic crystal and high voltage is applied across the crystal through the plasma electrode to initiate optical switching. In October 1991 we began evaluating materials suggested for the large aperture plasma electrode optical switch. Previous experiments suggested that switching performance could be significantly affected by the deterioration of cell materials. The final prototype switch tested used polyethylene for the switch body, Mykroy for the mid-plane and a silicone vulcanite to encapsulate the KD*P crystal. The encapsulant easily compensated for the effect of assembling the optical switch and no strain-induced birefringence in the crystal after encapsulation was measured. Oxygen was eventually added to the plasma to react with the sputtered carbon from the cathode and produce a gaseous effluent. As an added benefit, the production of ozone absorbed most of the ultraviolet radiation affecting the encapsulant. All the materials tested decomposed and produced volatiles, although no change in the damage threshold of exposed optical surfaces tested to date was seen. An evaluation of the recommended materials for major cell components using published manufacturers data, experimental results from our Material Evaluation Apparatus, and outgassing performance and sputtering data produced at the Laboratory's Vacuum Process Lab is presented.

  3. Tier 1 ecological evaluation of proposed discharge of dredged material from Oakland Harbor into ocean waters

    SciTech Connect

    Shreffler, D.K.; Thorn, R.M.; Walls, B.E.; Word, J.Q.

    1994-01-01

    The Water Resources Development Act of 1986 (Public Law 99--662) authorized the U.S. Army Corps of Engineers (USACE) -- San Francisco District, to accommodate larger, deeper draft vessels in Oakland inner and Outer Harbors by deepening and widening the existing navigation channel, and providing turning basins and maneuvering areas in Oakland inner Harbor. The suitability of the resulting dredged material for disposal into ocean waters was subject to the procedures of the 1991 Testing Manual, Evaluation of Dredged Material Proposed for Ocean Disposal, known as the ``Green Book``. The Green Book provides a tiered approach for testing the suitability of dredged materials through chemical, physical, and biological evaluations. The first level of investigation, or Tier 1 evaluation, is used to determine whether a decision on LPC compliance can be made on the basis of readily available information. The Tier 1 report primarily summarizes existing information on sediment contamination and toxicity potential, identifies contaminants of concern, and determines the need for further testing. To assist the USACE in determining the suitability of dredged material from Oakland inner and Outer Harbors for ocean disposal, Battelle/Marine Sciences Laboratory prepared this Tier 1 report based upon information and data provided by USACE. Because this Tier 1 report originated well after an LPC determination was made to require testing of project sediments in Tier 3, the primary purpose of this report was to identify contaminants of concern (if any) in that particular dredged material. In addition, this Tier 1 report summarizes available information on chemical, physical, and biological characterization of the sediments in Oakland inner and Outer Harbors.

  4. Standardized patients in audiology: a proposal for a new method of evaluating clinical competence.

    PubMed

    Dinsmore, Brooke Freeman; Bohnert, Carrie; Preminger, Jill E

    2013-05-01

    While accrediting organizations require AuD programs to provide evidence that their students are able to demonstrate knowledge and competencies in specific content areas, there are no generally accepted mechanisms for the assessment and the measurement of these proficiencies. We propose that AuD programs consider developing standardized patient (SP) cases in order to develop consistent summative assessment programs within and across universities. The purpose of this article is to provide a framework for establishing SP programs to evaluate competencies in AuD students by detailing the history of SP cases and their use, developing a rationale for this method of assessment, and outlining the steps for writing and implementing SP cases. Literature review. SPs have been used to assess clinical competence in medical students for over 50 yr. The prevalence of SP assessment in allied health professions (e.g., dentistry, psychology, pharmacy) has increased over the last two decades but has only gained a limited following in audiology. SP assessment has been implemented in medical education using the Objective Structured Clinical Examination, a multistation, timed exam that uses fictional cases to assess students' clinical abilities. To date, only one published report has been completed that evaluates the use of SPs to assess clinical abilities in audiology students. This article expands upon the work of English et al (2007) and their efforts to use SPs to evaluate counseling abilities. To this end, we describe the steps necessary to write a case, procedures to determine performance requirements, and the need to develop remediation plans. As an example, we include a case that we have developed in order to evaluate vestibular assessment and patient communication skills. Utilizing SP assessment in audiology education would provide useful means to evaluate competence in a uniform way. Future research is necessary to develop reliable and valid cases that may be implemented

  5. Proposed Facility Modifications to Support Propulsion Systems Testing Under Simulated Space Conditions at Plum Brook Station's Spacecraft Propulsion Research Facility (B-2)

    NASA Technical Reports Server (NTRS)

    Edwards, Daryl A.

    2007-01-01

    Preparing NASA's Plum Brook Station's Spacecraft Propulsion Research Facility (B-2) to support NASA's new generation of launch vehicles has raised many challenges for B-2 s support staff. The facility provides a unique capability to test chemical propulsion systems/vehicles while simulating space thermal and vacuum environments. Designed and constructed 4 decades ago to support upper stage cryogenic engine/vehicle system development, the Plum Brook Station B-2 facility will require modifications to support the larger, more powerful, and more advanced engine systems for the next generation of vehicles leaving earth's orbit. Engine design improvements over the years have included large area expansion ratio nozzles, greater combustion chamber pressures, and advanced materials. Consequently, it has become necessary to determine what facility changes are required and how the facility can be adapted to support varying customers and their specific test needs. Instrumental in this task is understanding the present facility capabilities and identifying what reasonable changes can be implemented. A variety of approaches and analytical tools are being employed to gain this understanding. This paper discusses some of the challenges in applying these tools to this project and expected facility configuration to support the varying customer needs.

  6. Proposed Facility Modifications to Support Propulsion Systems Testing Under Simulated Space Conditions at Plum Brook Station's Spacecraft Propulsion Research Facility (B-2)

    NASA Technical Reports Server (NTRS)

    Edwards, Daryl A.

    2008-01-01

    Preparing NASA's Plum Brook Station's Spacecraft Propulsion Research Facility (B-2) to support NASA's new generation of launch vehicles has raised many challenges for B-2's support staff. The facility provides a unique capability to test chemical propulsion systems/vehicles while simulating space thermal and vacuum environments. Designed and constructed in the early 1960s to support upper stage cryogenic engine/vehicle system development, the Plum Brook Station B-2 facility will require modifications to support the larger, more powerful, and more advanced engine systems for the next generation of vehicles leaving earth's orbit. Engine design improvements over the years have included large area expansion ratio nozzles, greater combustion chamber pressures, and advanced materials. Consequently, it has become necessary to determine what facility changes are required and how the facility can be adapted to support varying customers and their specific test needs. Exhaust system performance, including understanding the present facility capabilities, is the primary focus of this work. A variety of approaches and analytical tools are being employed to gain this understanding. This presentation discusses some of the challenges in applying these tools to this project and expected facility configuration to support the varying customer needs.

  7. 77 FR 9876 - Proposed Modification of VOR Federal Airways V-10, V-12, and V-508 in the Vicinity of Olathe, KS

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... proposing this action to adjust the airway route structure due to the planned decommissioning of the Johnson County VOR/ DME navigation aid located on Johnson County Executive Airport, Olathe, KS. DATES: Comments... The Kansas City Air Route Traffic Control Center requested the decommissioning of the Johnson County...

  8. Evaluation and modification of ASPEN fixed-bed gasifier models for inclusion in an integrated gasification combined-cycle power plant simulation

    SciTech Connect

    Stefano, J.M.

    1985-05-01

    Several Advanced System for Process Engineering (ASPEN) fixed-bed gasifier models have been evaluated to determine which is the most suitable model for use in an integrated gasification combined-cycle (IGCC) power plant simulation. Four existing ASPEN models were considered: RGAS, a dry ash gasifier model developed by Halcon/Scientific Design Company; USRWEN, the WEN II dry ash gasifier model originally developed by C.Y. Wen at West Virginia University; the slagging gasifier model developed by Massachusetts Institute of Technology (MIT) and based on Continental Oil Company's (CONOCO) design study for the proposed Pipeline Demonstration Plant; and the ORNL dry ash gasifier model developed by Oak Ridge National Laboratory for the simulation of the Tri-States Indirect Liquefaction Process. Because none of the models studied were suitable in their present form for inclusion in an IGCC power plant simulation, the SLAGGER model was developed by making significant modifications to the MIT model. The major problems with the existing ASPEN models were most often inaccurate material and energy balances, limitations of coal type, or long run times. The SLAGGER model includes simplifications and improvements over the MIT model, runs quickly (less than 30 seconds of computer time on a VAX-11/780), and gives more accurate mass and energy balances.

  9. Notification: Preliminary Research to Evaluate Proposed Superfund Sites on the U.S. EPA's National Priorities List

    EPA Pesticide Factsheets

    Project #OPE-FY13-0018, April 4, 2013. The Office of Inspector General plans to begin preliminary research to evaluate proposed Superfund sites on the U.S. Environmental Protection Agency’s National Priorities List.

  10. 45 CFR 690.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... proposals for research to be conducted or supported by a Federal department or agency. 690.120 Section 690.120 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.120 Evaluation and disposition of applications and proposals for research...

  11. 23 CFR 636.303 - May pre-qualification standards be used as proposal evaluation criteria in the RFP?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false May pre-qualification standards be used as proposal evaluation criteria in the RFP? 636.303 Section 636.303 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal...

  12. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120...

  13. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120...

  14. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120...

  15. 40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.120 Evaluation and disposition of applications and proposals for research to be conducted or supported... applications and proposals for research to be conducted or supported by a Federal Department or Agency. 26.120...

  16. 40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.120 Evaluation and disposition of applications and proposals for research to be conducted or supported... applications and proposals for research to be conducted or supported by a Federal Department or Agency. 26.120...

  17. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120...

  18. 40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.120 Evaluation and disposition of applications and proposals for research to be conducted or supported... applications and proposals for research to be conducted or supported by a Federal Department or Agency. 26.120...

  19. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120...

  20. 34 CFR 97.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a... proposals for research to be conducted or supported by a Federal Department or Agency. 97.120 Section 97.120...

  1. 40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26.120 Evaluation and disposition of applications and proposals for research to be conducted or supported... applications and proposals for research to be conducted or supported by a Federal Department or Agency. 26.120...

  2. 23 CFR 636.303 - May pre-qualification standards be used as proposal evaluation criteria in the RFP?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false May pre-qualification standards be used as proposal evaluation criteria in the RFP? 636.303 Section 636.303 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal...

  3. 45 CFR 690.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... proposals for research to be conducted or supported by a Federal department or agency. 690.120 Section 690.120 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.120 Evaluation and disposition of applications and proposals for research...

  4. 78 FR 44579 - 30-Day Notice of Proposed Information Collection: Fellowship Placement Pilot Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... URBAN DEVELOPMENT 30-Day Notice of Proposed Information Collection: Fellowship Placement Pilot Program.... A. Overview of Information Collection Title of Information Collection: Fellowship Placement Pilot.... Description of the need for the information and proposed use: The Fellowship Placement Program places...

  5. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... proposal under the applicable selection factor and in comparison to the other proposals received, if any... selection factors may not exceed a total of three. (b) The Director will then assign a cumulative...

  6. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... proposal under the applicable selection factor and in comparison to the other proposals received, if any... selection factors may not exceed a total of three. (b) The Director will then assign a cumulative...

  7. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... proposal under the applicable selection factor and in comparison to the other proposals received, if any... selection factors may not exceed a total of three. (b) The Director will then assign a cumulative...

  8. ARSENIC REMOVAL FROM DRINKING WATER BY PROCESS MODIFICATION TO COAGULATION/FILTRATION. USEPA DEMONSTRATION PROJECT AT LIDGERWOOD, ND. FINAL PERFORMANCE EVALUATION REPORT

    EPA Science Inventory

    This report documents the activities performed and the results obtained for the arsenic removal treatment technology demonstration project at the Lidgerwood, North Dakota site. The objectives of the project were to evaluate: (1) the effectiveness of process modifications to an e...

  9. ARSENIC REMOVAL FROM DRINKING WATER BY PROCESS MODIFICATION TO COAGULATION/FILTRATION. USEPA DEMONSTRATION PROJECT AT LIDGERWOOD, ND. FINAL PERFORMANCE EVALUATION REPORT

    EPA Science Inventory

    This report documents the activities performed and the results obtained for the arsenic removal treatment technology demonstration project at the Lidgerwood, North Dakota site. The objectives of the project were to evaluate: (1) the effectiveness of process modifications to an e...

  10. Evaluation of proposed sediment quality criteria for metals in marine and freshwater surficial sediments

    SciTech Connect

    Hoke, R.; Leonard, E.; Ankley, G.

    1995-12-31

    A proposed approach to sediment quality criteria (SQC) for five metals (copper, cadmium, zinc, nickel, and lead) was evaluated with surficial sediments collected from Lake Michigan and the Virginian Province of the east coast of the US Environmental Monitoring and Assessment Program of the US Environmental Protection Agency. Concentrations of acid volatile sulfide (AVS), simultaneously extracted metals (SEM), total metals, and total organic carbon were measured in the sediments. Interstitial (pore) water concentrations of the five metals also were measured in the freshwater sediment samples. Overall, > 90% and 59% of surficial marine and freshwater sediments contained detectable AVS, respectively. Approximately 90% of the marine sediments contained greater concentrations of AVS that total SEM (molar sum of copper, cadmium, zinc, nickel, and lead); suggesting minimal bioavailability of the five metals. A smaller proportion of the freshwater samples (30%) contained greater concentrations of AVS than total SEM. However, pore water concentrations of the five metals were uniformly low and never exceeded approximately 0.3 toxic units using an additive toxicity model based on Final Chronic Values from EPA Water Quality Criteria.

  11. Ergonomic evaluation of interior design of Shoka vehicle and proposing recommendations for improvement.

    PubMed

    Mazloumi, Adel; Mohammadreze, Fallah

    2012-01-01

    One of the applications of ergonomics disciplinary is designing driver workstation compatible to users' characteristics. The aim of this study was evaluation of interior design of Shoka vehicle with respect to the accommodation for Iranian population and proposing suggestions for customizing design of this vehicle. This study was a descriptive-analytical study conducted among thirty men from Iranian drivers population in 5, 50, 95 percentiles of the stature variable. Objective variables related to the occupant packaging and vehicle visual aspects including anthropometric variables, frontal, lateral, and side view and so on were investigated first. Then, subjective variables related to the driver mental workload and body comfort discomfort were studied using BMDMW and comfort questionnaires during 2-hour driving trial sessions. Occupant packaging variables and hand-arm angle showed the least accommodation percent (%53). Seating angles showed low accommodation as well (%73). Among three percentile groups there were no significant differences between the mean values of mental workload during two hours driving task. And, the mean value related to the comfort discomfort was 3.9 during driving sessions. Considering the findings in this study, it can be conclude that seating angles need correction and optimization. Taking mental workload results into account, it can be concluded that the interior design of the studied car had no influence on drivers' mental workload. From the aspect of comfort discomfort, Shoka vehicle showed neutral state among drivers. Optimizing seating angles, decreasing vibration, correcting stiffness of seating pan are suggested for customization of the ergonomics aspect of this vehicle.

  12. Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in Humans.

    PubMed

    Momper, Jeremiah D; Tsunoda, Shirley M; Ma, Joseph D

    2016-07-01

    Drug transporters are present in various tissues and have a significant role in drug absorption, distribution, and elimination. The International Transporter Consortium has identified 7 transporters of increasing importance from evidence of clinically significant transporter-mediated drug-drug interactions. The transporters are P-glycoprotein, breast cancer resistance protein, organic anion transporting polypeptide (OATP) 1B1, OATP1B3, organic cation transporter 2, organic anion transporters (OAT) 1, and OAT3. Decision trees were created based on in vitro experiments to determine whether an in vivo transporter-mediated drug-drug interaction study is needed. Phenotyping is a methodology that evaluates real-time in vivo transporter activity, whereby changes in a probe substrate or probe inhibitor reflect alternations in the activity of the specified transporter. In vivo probe substrates and/or probe inhibitors have been proposed for each aforementioned transporter. In vitro findings and animal models provide the strongest evidence regarding probe specificity. However, such findings have not conclusively correlated with human phenotyping studies. Furthermore, the extent of contribution from multiple transporters in probe disposition complicates the ability to discern if study findings are the result of a specific transporter and thus provide a recommendation for a preferred probe for a drug transporter. © 2016, The American College of Clinical Pharmacology.

  13. The Cotingo Dam as a Test of Brazil's System for Evaluating Proposed Developments in Amazonia

    PubMed

    Fearnside; Barbosa

    1996-09-01

    The proposed Cotingo Dam in Brazil's far northern state of Roraima is examined with the objective of drawing lessons for Brazil's system of evaluating environmental, social, and financial consequences of development decisions. The Cotingo Dam illustrates the difficulty of translating into practice the principles of economic and environmental assessment. Examination of the financial arguments for the Cotingo Dam indicates that justifications in this sphere are insufficient to explain why the project is favored over other alternatives and points to political factors as the best explanation of the project's high priority. Strong pressure from political and entrepreneurial interest groups almost invariably dominates decision making in Amazonia. The analysis indicates the inherent tendency of the present system to produce decisions in favor of large construction projects at the expense of the environment and local peoples. The requirements intended to assure proper weight for these concerns, such as the report on environmental impacts (RIMA) and the public hearing, fail to serve this role. Cotingo also provides a test case for constitutional protections restricting construction of dams in indigenous lands.KEY WORDS: Hydroelectric dams; Amazonia; Indigenous peoples; Brazil; Roraima

  14. Outcome Evaluation of a Policy-Mandated Lifestyle and Environmental Modification Program in a National Job Training Center.

    PubMed

    Jimenez, Elizabeth Yakes; Harris, Amanda; Luna, Donald; Velasquez, Daniel; Slovik, Jonathan; Kong, Alberta

    2016-10-18

    Excess weight gain is common when adolescents become young adults, but there are no obesity prevention or weight management interventions that have been tested for emerging adults who follow non-traditional post-secondary paths, such as enrolling in job training programs. We evaluated Healthy Eating & Active Lifestyles (HEALs), a policy-mandated lifestyle education/environmental modification program, at a job training center for low-income 16-24 year olds. We examined average change in body mass index (BMI) z-score from baseline to 6 months for emerging adults (aged 16-24 years) in pre-HEALs implementation (n = 125) and post-HEALs implementation (n = 126) cohorts living at the job training center, by baseline weight status. In both cohorts, average BMI z-score significantly increased from baseline to 6 months for students with BMI < 25. Average BMI z-score significantly decreased for the overweight (BMI 25 to <30; -0.11, p = .03) and obese (BMI ≥ 30; -0.11, p = .001) students only within the post-HEALs cohort; changes within the pre-HEALs cohort and between cohorts were not significant. HEALs may promote positive weight-related trends for overweight/obese students, but prevention efforts for non-overweight/obese students need to be improved.

  15. Surface modification of PdlLGA microspheres with gelatine methacrylate: Evaluation of adsorption, entrapment, and oxygen plasma treatment approaches.

    PubMed

    Baki, Abdulrahman; Rahman, Cheryl V; White, Lisa J; Scurr, David J; Qutachi, Omar; Shakesheff, Kevin M

    2017-01-16

    Injectable poly (dl-lactic-co-glycolic acid) (PdlLGA) microspheres are promising candidates as biodegradable controlled release carriers for drug and cell delivery applications; however, they have limited functional groups on the surface to enable dense grafting of tissue specific biocompatible molecules. In this study we have evaluated surface adsorption, entrapment and oxygen plasma treatment as three approaches to modify the surfaces of PdlLGA microspheres with gelatine methacrylate (gel-MA) as a biocompatible and photo cross-linkable macromolecule. Time of flight secondary ion mass spectroscopy (TOF SIMS) and X-ray photoelectron spectroscopy (XPS) were used to detect and quantify gel-MA on the surfaces. Fluorescent and scanning electron microscopies (SEM) were used to image the topographical changes. Human mesenchymal stem cells (hMSCs) of immortalised cell line were cultured on the surface of gel-MA modified PdlLGA microspheres and Presto-Blue assay was used to study the effect of different surface modifications on cell proliferation. Data analysis showed that the oxygen plasma treatment approach resulted in the highest density of gel-MA deposition. This study supports oxygen plasma treatment as a facile approach to modify the surface of injectable PdlLGA microspheres with macromolecules such as gel-MA to enhance proliferation rate of injected cells and potentially enable further grafting of tissue specific molecules.

  16. 78 FR 19723 - Proposed Collection; 60-Day Comment Request; Evaluation of the Brain Disorders in the Developing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... HUMAN SERVICES National Institutes of Health Proposed Collection; 60-Day Comment Request; Evaluation of the Brain Disorders in the Developing World Program of the John E. Fogarty International Center...: Evaluation of the Brain Disorders in the Developing World Program of the John E. Fogarty International...

  17. STEMs: A Proposal for Calibrated Classroom Assessments That Increase Student Motivation and Provide Authentic Evaluation of Student Learning

    ERIC Educational Resources Information Center

    Murrieta, Hector; Amerson, Gordon

    2011-01-01

    The purpose of this study was to validate the development and proposal of what the authors call STEMs (Standards Tests to Evaluate Mastery) and have defined them as calibrated classroom assessments that increase student motivation and provide authentic evaluation of student learning. Theoretical and empirical research on classroom assessment and…

  18. 34 CFR 413.22 - What selection criteria does the Secretary use to evaluate an application proposing dissemination...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What selection criteria does the Secretary use to evaluate an application proposing dissemination and training activities? 413.22 Section 413.22 Education... Secretary Make an Award? § 413.22 What selection criteria does the Secretary use to evaluate an application...

  19. 78 FR 31999 - 30-Day Notice of Proposed Information Collection: Young Turkey/Young America Evaluation (YTYA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE 30-Day Notice of Proposed Information Collection: Young Turkey/ Young America Evaluation (YTYA) Survey ACTION... Collection: Young Turkey/Young America Evaluation (YTYA) Survey. OMB Control Number: None. Type of Request...

  20. [Physical activity patterns of school adolescents: Validity, reliability and percentiles proposal for their evaluation].

    PubMed

    Cossío Bolaños, Marco; Méndez Cornejo, Jorge; Luarte Rocha, Cristian; Vargas Vitoria, Rodrigo; Canqui Flores, Bernabé; Gomez Campos, Rossana

    2016-08-16

    Regular physical activity (PA) during childhood and adolescence is important for the prevention of non-communicable diseases and their risk factors. To validate a questionnaire for measuring patterns of PA, verify the reliability, comparing the levels of PA aligned with chronological and biological age, and to develop percentile curves to assess PA levels depending on biological maturation. Descriptive cross-sectional study was performed on a sample non-probabilistic quota of 3,176 Chilean adolescents (1685 males and 1491 females), with a mean age range from 10.0 to 18.9 years. An analysis was performed on, weight, standing and sitting height. The biological age through the years of peak growth rate and chronological age in years was determined. Body Mass Index was calculated and a survey of PA was applied. The LMS method was used to develop percentiles. The values for the confirmatory analysis showed saturations between 0.517 and 0.653. The value of adequacy of Kaiser-Meyer-Olkin (KMO) was 0.879 and with 70.8% of the variance explained. The Cronbach alpha values ranged from 0.81 to 0.86. There were differences between the genders when aligned chronological age. There were no differences when aligned by biological age. Percentiles are proposed to classify the PA of adolescents of both genders according to biological age and sex. The questionnaire used was valid and reliable, plus the PA should be evaluated by biological age. These findings led to the development of percentiles to assess PA according to biological age and gender. Copyright © 2016 Sociedad Chilena de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

  1. [Physical activity patterns of school adolescents: Validity, reliability and percentiles proposal for their evaluation].

    PubMed

    Cossío Bolaños, Marco; Méndez Cornejo, Jorge; Luarte Rocha, Cristian; Vargas Vitoria, Rodrigo; Canqui Flores, Bernabé; Gomez Campos, Rossana

    2017-02-01

    Regular physical activity (PA) during childhood and adolescence is important for the prevention of non-communicable diseases and their risk factors. To validate a questionnaire for measuring patterns of PA, verify the reliability, comparing the levels of PA aligned with chronological and biological age, and to develop percentile curves to assess PA levels depending on biological maturation. Descriptive cross-sectional study was performed on a sample non-probabilistic quota of 3,176 Chilean adolescents (1685 males and 1491 females), with a mean age range from 10.0 to 18.9 years. An analysis was performed on, weight, standing and sitting height. The biological age through the years of peak growth rate and chronological age in years was determined. Body Mass Index was calculated and a survey of PA was applied. The LMS method was used to develop percentiles. The values for the confirmatory analysis showed saturations between 0.517 and 0.653. The value of adequacy of Kaiser-Meyer-Olkin (KMO) was 0.879 and with 70.8% of the variance explained. The Cronbach alpha values ranged from 0.81 to 0.86. There were differences between the genders when aligned chronological age. There were no differences when aligned by biological age. Percentiles are proposed to classify the PA of adolescents of both genders according to biological age and sex. The questionnaire used was valid and reliable, plus the PA should be evaluated by biological age. These findings led to the development of percentiles to assess PA according to biological age and gender.

  2. Evaluation of a proposed molecular methodology for the serotyping of Avibacterium paragallinarum.

    PubMed

    Wang, Hongjun; Sun, Huiling; Blackall, Patrick J; Zhang, Zhenhua; Zhou, Hongzhuan; Xu, Fuzhou; Chen, Xiaoling

    2016-09-01

    A multiplex (m)PCR and a PCR followed by restriction fragment length polymorphism (RFLP) analysis of Avibacterium paragallinarum have been proposed as alternatives to conventional serotyping by the Page scheme. We evaluated both methods, and also sequenced the PCR-RFLP target fragment to reexamine the capacity of molecular serotyping. Eleven reference strains and 27 field isolates were used. Many reference strains and isolates were misidentified as Page serogroup B. The sequence analysis revealed 6 profiles based on the matching rates of the target sequence with the 3 reverse primers of the mPCR. The reference strains and field isolates in profiles 1 and 4 were correctly identified as serogroup A or C by the mPCR. The strains and/or isolates in profiles 2, 3, 5, and 6 could be misidentified as serogroup B or as nontypeable by the mPCR. The homology comparison of the sequences showed that the target sequence of the mPCR, called region 2, was not Page serogroup specific, although some Kume serovars, such as A-1 and C-2, were correctly serotyped. In addition, there was a 9 nucleotide deletion in the sequences of profiles 1, 3, and 5, but not of profiles 2, 4, and 6. Overall, we confirmed that the mPCR and PCR-RFLP molecular assays are not suitable for identifying the serogroups of A. paragallinarum isolates. With further study, analysis of region 2 sequences may have potential as a means of recognizing the Kume serovars of A. paragallinarum isolates.

  3. Evaluation of a Proposed Biodegradable 188Re Source for Brachytherapy Application

    PubMed Central

    Khorshidi, Abdollah; Ahmadinejad, Marjan; Hamed Hosseini, S.

    2015-01-01

    Abstract This study aimed to evaluate dosimetric characteristics based on Monte Carlo (MC) simulations for a proposed beta emitter bioglass 188Re seed for internal radiotherapy applications. The bioactive glass seed has been developed using the sol-gel technique. The simulations were performed for the seed using MC radiation transport code to investigate the dosimetric factors recommended by the AAPM Task Group 60 (TG-60). Dose distributions due to the beta and photon radiation were predicted at different radial distances surrounding the source. The dose rate in water at the reference point was calculated to be 7.43 ± 0.5 cGy/h/μCi. The dosimetric factors consisting of the reference point dose rate, D(r0,θ0), the radial dose function, g(r), the 2-dimensional anisotropy function, F(r,θ), the 1-dimensional anisotropy function, φan(r), and the R90 quantity were estimated and compared with several available beta-emitting sources. The element 188Re incorporated in bioactive glasses produced by the sol-gel technique provides a suitable solution for producing new materials for seed implants applied to brachytherapy applications in prostate and liver cancers treatment. Dose distribution of 188Re seed was greater isotropic than other commercially attainable encapsulated seeds, since it has no end weld to attenuate radiation. The beta radiation-emitting 188Re source provides high doses of local radiation to the tumor tissue and the short range of the beta particles limit damage to the adjacent normal tissue. PMID:26181543

  4. 48 CFR 215.203-70 - Requests for proposals-tiered evaluation of offers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 215.203-70 Requests for...

  5. Behavior modification.

    PubMed

    Pelham, W E; Fabiano, G A

    2000-07-01

    Attention deficit/hyperactivity disorder (ADHD) is a chronic and substantially impairing disorder. This means that treatment must also be chronic and substantial. Behavior Modification, and in many cases, the combination of behavior modification and stimulant medication, is a valid, useful treatment for reducing the pervasive impairment experienced by children with ADHD. Based on the research evidence reviewed, behavior modification should be the first line of treatment for children with ADHD.

  6. 76 FR 77260 - Proposed Information Collection Request (ICR) for the Evaluation of the Unemployment Compensation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... Policy Research and its subcontractor, Urban Institute, to conduct this evaluation. The evaluation will... Information Collection Request (ICR) for the Evaluation of the Unemployment Compensation Provisions of the... comments to Jonathan Simonetta, U.S. Department of Labor, Office of the Chief Evaluation Officer, 200...

  7. Environmental Baseline Survey for Proposed Land Use Permit Modification for Expansion of the Dynamic Explosive Test Site (DETS) 9940 Main Complex Parking Lot.

    SciTech Connect

    Peek, Dennis W.

    2016-02-01

    The approach was to perform a document search, supplemented by a visual site inspection, to identify potential environmental contamination associated with the property. Factors evaluated included hazardous substances; petroleum products and derivatives; environmental restoration sites; areas of concern; storage tanks; oil/water separators; grease traps; wash racks; waste tanks; pesticides; military munitions/ordnance; medical or bio-hazardous waste; radioactive waste; solid/municipal waste; indoor air quality; groundwater; wastewater treatment, collection, and disposal/discharge; drinking water quality; utilities; asbestos; polychlorinated biphenyls (PCBs); radon; lead-based paint; cultural resources; floodplains; and natural/biological resources.

  8. 77 FR 30050 - VASRD Status Summit: A Public Overview of Proposed Disability Evaluation Criteria

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... following nine body systems: (1) The Hemic and Lymphatic Systems (38 CFR 4.117), (2) The Endocrine System... Summit is to capture public comments on working drafts of proposed regulations for nine body ] systems... their input, prior to the drafting of proposed regulations for the body systems. VA plans to use...

  9. Evaluation of reagentless pH modification for in situ ocean analysis: determination of dissolved inorganic carbon using mass spectrometry.

    PubMed

    Cardenas-Valencia, Andres M; Adornato, Lori R; Bell, Ryan J; Byrne, Robert H; Short, R Timothy

    2013-03-15

    In situ analytical techniques that require the storage and delivery of reagents (e.g., acidic or basic solutions) have inherent durability limitations. The reagentless electrolytic technique for pH modification presented here was developed primarily to ease and to extend the longevity of dissolved inorganic carbon (DIC) determinations in seawater, but can also be used for other analytical methods. DIC, a primary carbon dioxide (CO(2)) system variable along with alkalinity, controls seawater pH, carbonate saturation state, and CO(2) fugacity. Determinations of these parameters are central to an understanding of ocean acidification and global climate change. Electrodes fabricated with electroactive materials, including manganese(III) oxide (Mn(2)O(3)) and palladium (Pd), were examined for potential use in electrolytic acidification. In-line acidification techniques were evaluated using a bench-top membrane introduction mass spectrometry (MIMS) setup to determine the DIC content of artificial seawater. Linear least-squares (LLSQ) calibrations for DIC concentration determinations over a range between 1650 and 2400 µmol kg(-1) were obtained, using both the novel electrolytic and conventional acid addition techniques. At sample rates of 4.5 mL min(-1), electrodes clad with Mn(2)O(3) and Pd were able to change seawater pH from 7.6 to 2.8 with a power consumption of less than 3 W. Although calibration curves were influenced by sampling rates at a flow of 4.5 mL min(-1), the 1σ measurement precision for DIC was of the order of ±20 µmol kg(-1). Calibrations obtained with the novel reagentless technique and the in-line addition of strong acid showed similar capabilities for DIC quantification. However, calculations of power savings for the reagentless technique relative to the mechanical delivery of stored acid demonstrated substantial advantages of the electrolytic technique for long-term deployments (>1 year). Copyright © 2013 John Wiley & Sons, Ltd.

  10. 76 FR 25723 - Proposed Information Collection for Growing America Through Entrepreneurship (GATE) II Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... Entrepreneurship (GATE) II Evaluation; Comment Request AGENCY: Employment and Training Administration, Labor... that investigated the impact of providing entrepreneurship training services to individuals interested..., K., & Kahvecioglu, D. ``Growing America Through Entrepreneurship: Findings from the Evaluation of...

  11. 78 FR 11652 - Agency Information Collection Activities; Proposed Collection; Comment Request; Evaluation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... Collection; Comment Request; Evaluation of the Program for Enhanced Review Transparency and Communication for... the Program for Enhanced Review Transparency and Communication (``the Program'') during fiscal years... of information technology. Evaluation of the Program for Enhanced Review Transparency and...

  12. Evaluation and proposal of novel resectability criteria for pancreatic cancer established by the Japan Pancreas Society.

    PubMed

    Yamada, Suguru; Fujii, Tsutomu; Takami, Hideki; Hayashi, Masamichi; Iwata, Naoki; Kanda, Mitsuro; Tanaka, Chie; Sugimoto, Hiroyuki; Nakayama, Goro; Koike, Masahiko; Fujiwara, Michitaka; Kodera, Yasuhiro

    2017-10-01

    The guidelines for the classification of the resectability of pancreatic cancer established by the National Comprehensive Cancer Network can be difficult to utilize in clinical practice. We evaluated novel criteria proposed by the Japan Pancreas Society. We analyzed 382 patients with pancreatic cancer between 2001 and 2015 for survival differences among subgroups classified according to the Japan Pancreas Society classification. Overall survival and disease-free survival were expressed as median values and compared with data based on the National Comprehensive Cancer Network classification, and differences in initial patterns of recurrence were analyzed. Overall survival times according to the Japan Pancreas Society criteria were 34.2, 29.7, 17.3, 14.3, and 15.8 months for the groups defined as resectable, resectable with portal vein invasion, borderline resectable with portal vein invasion, borderline resectable with arterial invasion, and unresectable by locally advanced disease respectively. The overall survival of the resectable group was better than those of the borderline resectable with portal vein invasion or borderline resectable with arterial invasion groups (P < .0001); however, the borderline resectable with portal vein invasion, borderline resectable with arterial invasion, and unresectable by locally advanced groups showed no differences in overall survival. The resectable group showed a tendency toward better survival than the resectable with portal vein invasion group (P = .058). The median overall survival times according to the classic 2012 National Comprehensive Cancer Network criteria were 30.5, 20.5, 15.8, and 13.8 months for the resectable, portal invasion, common hepatic artery and superior mesenteric artery invasion groups, respectively. Each survival curve was clearly separate. The borderline resectable with arterial invasion and unresectable by locally advanced groups exhibited high local recurrence rates (42.0% and 44

  13. 76 FR 9607 - Notice of Proposed Information Collection for Technical Evaluation Surveys

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... Technical Evaluation Surveys AGENCY: Office of Surface Mining Reclamation and Enforcement, Interior. ACTION... request for its Technical Evaluation customer surveys has been forwarded to the Office of Management and... its approval of the collection of information contained in a series of technical evaluation customer...

  14. 77 FR 62518 - Proposed Collection; Comment Request: Recipient Epidemiology and Donor Evaluation Study-III (REDS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... Epidemiology and Donor Evaluation Study-III (REDS-III) Request for Generic Clearance SUMMARY: In compliance...: Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Type of Information Collection Request... Evaluation ] Study-III (REDS-III) program is to ensure safe and effective blood banking and transfusion...

  15. The modification and evaluation of an ELISA test for the surveillance of Mycobacterium avium subsp. paratuberculosis infection in wild ruminants

    PubMed Central

    2013-01-01

    developed. In order to generate reliable test results, it is essential to evaluate the test and perform modifications if deemed necessary. Despite the challenges inherent to wildlife diagnostics, we have shown that several methods can be used to improve confidence in test results. PMID:23302439

  16. 76 FR 63924 - Agency Information Collection Activities; Proposed Collection; Comment Request; the Evaluation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... opportunity for public comment on the proposed collection of certain information by the agency. Under the... analysis of the effect of the ADRC program on heath care utilization and nursing home diversion. The...

  17. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... commodity to the project. Applications that demonstrate high likelihood of success in these areas will... Medium-sized farm or ranch that is structured as a Family Farm, Mid Tier Value Chain proposals,...

  18. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... commodity to the project. Applications that demonstrate high likelihood of success in these areas will... Medium-sized farm or ranch that is structured as a Family Farm, Mid Tier Value Chain proposals,...

  19. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... commodity to the project. Applications that demonstrate high likelihood of success in these areas will... Medium-sized farm or ranch that is structured as a Family Farm, Mid Tier Value Chain proposals,...

  20. 78 FR 43214 - Proposed Collection; 60-day Comment Request Evaluation of a Kidney Disease Education and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... publish periodic summaries of proposed projects to be submitted to the Office of Management and Budget... estimated annualized burden hours are 101 (see table below). Table A.12.A--Estimate Annualized Burden...