Genetics Home Reference: factor XIII deficiency

MedlinePlus

... XIII deficiency tend to have heavy or prolonged menstrual bleeding (menorrhagia) and may experience recurrent pregnancy losses ( ... inheritance, which means that it results when both copies of either the F13A1 gene or the F13B ...

Characterization of carbonic anhydrase XIII in the erythrocytes of the Burmese python, Python molurus bivittatus.

PubMed

Esbaugh, A J; Secor, S M; Grosell, M

2015-09-01

Carbonic anhydrase (CA) is one of the most abundant proteins found in vertebrate erythrocytes with the majority of species expressing a low activity CA I and high activity CA II. However, several phylogenetic gaps remain in our understanding of the expansion of cytoplasmic CA in vertebrate erythrocytes. In particular, very little is known about isoforms from reptiles. The current study sought to characterize the erythrocyte isoforms from two squamate species, Python molurus and Nerodia rhombifer, which was combined with information from recent genome projects to address this important phylogenetic gap. Obtained sequences grouped closely with CA XIII in phylogenetic analyses. CA II mRNA transcripts were also found in erythrocytes, but found at less than half the levels of CA XIII. Structural analysis suggested similar biochemical activity as the respective mammalian isoforms, with CA XIII being a low activity isoform. Biochemical characterization verified that the majority of CA activity in the erythrocytes was due to a high activity CA II-like isoform; however, titration with copper supported the presence of two CA pools. The CA II-like pool accounted for 90 % of the total activity. To assess potential disparate roles of these isoforms a feeding stress was used to up-regulate CO2 excretion pathways. Significant up-regulation of CA II and the anion exchanger was observed; CA XIII was strongly down-regulated. While these results do not provide insight into the role of CA XIII in the erythrocytes, they do suggest that the presence of two isoforms is not simply a case of physiological redundancy. Copyright © 2015. Published by Elsevier Inc.

Traffic analysis toolbox volume XIII : integrated corridor management analysis, modeling, and simulation guide

DOT National Transportation Integrated Search

2017-02-01

As part of the Federal Highway Administration (FHWA) Traffic Analysis Toolbox (Volume XIII), this guide was designed to help corridor stakeholders implement the Integrated Corridor Management (ICM) Analysis, Modeling, and Simulation (AMS) methodology...

Traffic analysis toolbox volume XIII : integrated corridor management analysis, modeling, and simulation guide.

DOT National Transportation Integrated Search

2017-02-01

As part of the Federal Highway Administration (FHWA) Traffic Analysis Toolbox (Volume XIII), this guide was designed to help corridor stakeholders implement the Integrated Corridor Management (ICM) Analysis, Modeling, and Simulation (AMS) methodology...

Dirac R-matrix calculations of photoionization cross sections of Ni XII and atomic structure data of Ni XIII

NASA Astrophysics Data System (ADS)

Nazir, R. T.; Bari, M. A.; Bilal, M.; Sardar, S.; Nasim, M. H.; Salahuddin, M.

2017-02-01

We performed R-matrix calculations for photoionization cross sections of the two ground state configuration 3s23p5 (^2P^o3/2,1/2) levels and 12 excited states of Ni XII using relativistic Dirac Atomic R-matrix Codes (DARC) across the photon energy range between the ionizations thresholds of the corresponding states and well above the thresholds of the last level of the Ni XIII target ion. Generally, a good agreement is obtained between our results and the earlier theoretical photoionization cross sections. Moreover, we have used two independent fully relativistic GRASP and FAC codes to calculate fine-structure energy levels, wavelengths, oscillator strengths, transitions rates among the lowest 48 levels belonging to the configuration (3s23p4, 3s3p5, 3p6, 3s23p33d) in Ni XIII. Additionally, radiative lifetimes of all the excited states of Ni XIII are presented. Our results of the atomic structure of Ni XIII show good agreement with other theoretical and experimental results available in the literature. A good agreement is found between our calculated lifetimes and the experimental ones. Our present results are useful for plasma diagnostic of fusion and astrophysical plasmas.

76 FR 48563 - Medicare and Medicaid Programs; Quarterly Listing of Program Issuances-January Through March 2011...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-08

...-7205 Ventricular Assist Device (Destination Therapy) Facilities. XIII Medicare-Approved Lung JoAnna...-Approved Ventricular Assist Device (Destination Therapy) Facilities, Addendum XIII: Lung Volume Reduction...-Approved Ventricular Assist Device (Destination Therapy) Facilities (January Through March 2011) Addendum...

A specific colorimetric assay for measuring transglutaminase 1 and factor XIII activities.

PubMed

Hitomi, Kiyotaka; Kitamura, Miyako; Alea, Mileidys Perez; Ceylan, Ismail; Thomas, Vincent; El Alaoui, Saïd

2009-11-15

Transglutaminase (TGase) is an enzyme that catalyzes both isopeptide cross-linking and incorporation of primary amines into proteins. Eight TGases have been identified in humans, and each of these TGases has a unique tissue distribution and physiological significance. Although several assays for TGase enzymatic activity have been reported, it has been difficult to establish an assay for discriminating each of these different TGase activities. Using a random peptide library, we recently identified the preferred substrate sequences for three major TGases: TGase 1, TGase 2, and factor XIII. In this study, we use these substrates in specific tests for measuring the activities of TGase 1 and factor XIII.

Phylogenetic analysis of Newcastle disease viruses from Bangladesh suggests continuing evolution of genotype XIII.

PubMed

Barman, Lalita Rani; Nooruzzaman, Mohammed; Sarker, Rahul Deb; Rahman, Md Tazinur; Saife, Md Rajib Bin; Giasuddin, Mohammad; Das, Bidhan Chandra; Das, Priya Mohan; Chowdhury, Emdadul Haque; Islam, Mohammad Rafiqul

2017-10-01

A total of 23 Newcastle disease virus (NDV) isolates from Bangladesh taken between 2010 and 2012 were characterized on the basis of partial F gene sequences. All the isolates belonged to genotype XIII of class II NDV but segregated into three sub-clusters. One sub-cluster with 17 isolates aligned with sub-genotype XIIIc. The other two sub-clusters were phylogenetically distinct from the previously described sub-genotypes XIIIa, XIIIb and XIIIc and could be candidates of new sub-genotypes; however, that needs to be validated through full-length F gene sequence data. The results of the present study suggest that genotype XIII NDVs are under continuing evolution in Bangladesh.

25 CFR 36.40 - Standard XIII-Library/media program.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Standard XIII-Library/media program. 36.40 Section 36.40... § 36.40 Standard XIII—Library/media program. (a) Each school shall provide a library/media program... objectives have been met. (2) A written policy for the selection of materials and equipment shall be...

25 CFR 36.40 - Standard XIII-Library/media program.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Standard XIII-Library/media program. 36.40 Section 36.40... § 36.40 Standard XIII—Library/media program. (a) Each school shall provide a library/media program... developed by a library committee in collaboration with the librarian and be approved by the school board...

25 CFR 36.40 - Standard XIII-Library/media program.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Standard XIII-Library/media program. 36.40 Section 36.40... § 36.40 Standard XIII—Library/media program. (a) Each school shall provide a library/media program... developed by a library committee in collaboration with the librarian and be approved by the school board...

25 CFR 36.40 - Standard XIII-Library/media program.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Standard XIII-Library/media program. 36.40 Section 36.40... § 36.40 Standard XIII—Library/media program. (a) Each school shall provide a library/media program... developed by a library committee in collaboration with the librarian and be approved by the school board...

Development of Methodology and Technology for Identifying and Quantifying Emission Products from Open Burning and Open Detonation Thermal Treatment Methods. Bangbox Test Series. Volume 2. Test Development

DTIC Science & Technology

1992-01-01

Calculated by the Carbon Balance and by the C -V M ethod . ...................................... ... ... ... ... ... 6-8 x I I Table 6.3 EF for the...A-i APPENDIX B. SAMPLING AND DETERMINATION OF POLYCHLORINATED DIBENZODIOXINS AND DIBENZOFURANS ................. B-13 APPENDIX C . DISTRIBUTION... C -I I I I I I I I I I I I I I xiii I INTENTIONALLY BLANK xiv --I IACKNOWLEDGEMENTS I The following

[Factor XIII deficiency in burns].

PubMed

Burkhardt, H; Zellner, P R; Möller, I

1977-08-01

In 34 patients with severe burn injuries platelets, fibrinogen, prothrombin time, partial thromboplastin time, thrombin time and factor XIII were measured daily. Half of the patients were administered 15 000 IE of heparin per 24 hours. In the first 4 days there was a rapid fall of factor XIII to a value of approximately 30%. Values remained very low during the whole observation period of up to 20 days. However, in patients treated with heparin, values tended to be 10--15% higher. After an initial decline on the tenth day, the platelets had risen to the lowest normal level. Platelets were identical in both groups. The causes for the changes in these haemostasis parameters, their significance, and possible consequences of therapy are discussed.

Activation of tissue kallikrein-kininogen-kinin system in rabbit skin by a fraction isolated from Phoneutria nigriventer (armed spider) venom.

PubMed

Antunes, E; Marangoni, R A; Giglio, J R; Brain, S D; de Nucci, G

1993-11-01

Phoneutria nigriventer venom was fractionated by gel filtration followed by ion-exchange chromatography from which 16 fractions (I-XVI) were obtained and assayed in rabbit skin in order to identify those responsible for the increased vascular permeability observed with the whole venom. The fractions, and control mediators (tissue kallikrein, bradykinin and histamine) were intradermally injected in male New Zealand white rabbits. Local oedema formation was measured as the local accumulation of i.v. injected 125I-human serum albumin into skin sites. Fraction XIII was the only fraction assayed which significantly induced oedema formation. Fraction XIII-induced oedema was greatly reduced by either the protease inhibitor aprotinin or the bradykinin B2 receptor antagonist D-Arg,[Hyp3,Thi5,8D-Phe7]-Bk, whereas the plasma kallikrein inhibitor soybean trypsin inhibitor failed to significantly affect this oedematogenic response. The kininase II inhibitor captopril markedly potentiated fraction XIII-induced oedema. Our results indicate that the increased vascular permeability induced by fraction XIII is due to local generation of kinins in response to tissue (but not plasma) kallikrein-kinin system activation.

Evaluation of a Salmonella Strain Lacking the Secondary Messenger C-di-GMP and RpoS as a Live Oral Vaccine

PubMed Central

García, Begoña; Gil, Carmen; García-Ona, Enrique; Burgui, Saioa; Casares, Noelia; Hervás-Stubbs, Sandra; Lasarte, Juan José; Lasa, Iñigo

2016-01-01

Salmonellosis is one of the most important bacterial zoonotic diseases transmitted through the consumption of contaminated food, with chicken and pig related products being key reservoirs of infection. Although numerous studies on animal vaccination have been performed in order to reduce Salmonella prevalence, there is still a need for an ideal vaccine. Here, with the aim of constructing a novel live attenuated Salmonella vaccine candidate, we firstly analyzed the impact of the absence of cyclic-di-GMP (c-di-GMP) in Salmonella virulence. C-di-GMP is an intracellular second messenger that controls a wide range of bacterial processes, including biofilm formation and synthesis of virulence factors, and also modulates the host innate immune response. Our results showed that a Salmonella multiple mutant in the twelve genes encoding diguanylate cyclase proteins that, as a consequence, cannot synthesize c-di-GMP, presents a moderate attenuation in a systemic murine infection model. An additional mutation of the rpoS gene resulted in a synergic attenuating effect that led to a highly attenuated strain, referred to as ΔXIII, immunogenic enough to protect mice against a lethal oral challenge of a S. Typhimurium virulent strain. ΔXIII immunogenicity relied on activation of both antibody and cell mediated immune responses characterized by the production of opsonizing antibodies and the induction of significant levels of IFN-γ, TNF-α, IL-2, IL-17 and IL-10. ΔXIII was unable to form a biofilm and did not survive under desiccation conditions, indicating that it could be easily eliminated from the environment. Moreover, ΔXIII shows DIVA features that allow differentiation of infected and vaccinated animals. Altogether, these results show ΔXIII as a safe and effective live DIVA vaccine. PMID:27537839

Correlation between thyroidal and peripheral blood total T cells, CD8+ T cells, and CD8+ T- regulatory cells and T-cell reactivity to calsequestrin and collagen XIII in patients with Graves' ophthalmopathy.

PubMed

Al-Ansari, Farah; Lahooti, Hooshang; Stokes, Leanne; Edirimanne, Senarath; Wall, Jack

2018-05-22

Purpose/aim of the study: Graves' ophthalmopathy (GO) is closely related to the thyroid autoimmune disorder Graves' disease. Previous studies have suggested roles for thyroidal CD8 +  T cells and autoimmunity against calsequestrin-1 (CASQ)-1 in the link between thyroidal and orbital autoimmune reactions in GO. A role for autoimmunity against CollXIII has also been suggested. In this study, we aimed to investigate correlations between some thyroidal and peripheral blood T-cell subsets and thyroidal T-cell reactivity against CASQ1 and CollXIII in patients with GO. Fresh thyroid tissues were processed by enzyme digestion and density gradient to isolate mononuclear cells (MNCs). Peripheral blood MNCs were also isolated using density gradient. Flow-cytometric analysis was used to identify the various T-cell subsets. T -cell reactivity to CASQ1 and CollXIII was measured by a 5-day culture of the MNCs and BrdU uptake method. We found a positive correlation between thyroidal CD8 +  T cells and CD8 +  T-regulatory (T-reg) cells in patients with GO. Thyroidal T cells from two out of the three patients with GO tested (66.7%) showed a positive response to CASQ1, while thyroidal T cells from none of the six Graves' Disease patients without ophthalmopathy (GD) tested showed a positive response to this antigen. Thyroidal T cells from these patient groups however, showed no significant differences in their response to CollXIII. Our observations provide further evidence for a possible role of thyroidal CD8 +  T cells, CD8 +  T-reg cells and the autoantigen CASQ1 in the link between thyroidal and orbital autoimmune reactions of GO.

Proceedings of the XIII International Symposium on Biological Control of Weeds; September 11-16, 2011; Waikoloa, Hawaii, USA

Treesearch

Yun Wu; Tracy Johnson; Sharlene Sing; S. Raghu; Greg Wheeler; Paul Pratt; Keith Warner; Ted Center; John Goolsby; Richard Reardon

2013-01-01

A total of 208 participants from 78 organizations in 19 countries gathered at the Waikoloa Beach Marriott on the Big Island of Hawaii on September 11-16, 2011 for the XIII International Symposium on Biological Control of Weeds. Following a reception on the first evening, Symposium co-chairs Tracy Johnson and Pat Conant formally welcomed the attendees on the morning of...

Identification of a 'Candidatus Phytoplasma hispanicum'-related strain, associated with yellows-type diseases, in smoke-tree sharpshooter (Homalodisca liturata Ball).

PubMed

Servín-Villegas, Rosalía; Caamal-Chan, Maria Goretty; Chavez-Medina, Alicia; Loera-Muro, Abraham; Barraza, Aarón; Medina-Hernández, Diana; Holguín-Peña, Ramón Jaime

2018-04-11

The 16SrXIII group from phytoplasma bacteria were identified in salivary glands from Homalodisca liturata, which were collected in El Comitán on the Baja California peninsula in Mexico. We were able to positively identify 15 16S rRNA gene sequences with the corresponding signature sequence of 'CandidatusPhytoplasma' (CAAGAYBATKATGTKTAGCYGGDCT) and in silico restriction fragment length polymorphism (RFLP) profiles (F value estimations) coupled with a phylogenetic analysis to confirm their relatedness to 'CandidatusPhytoplasma hispanicum', which in turn belongs to the 16SrXIII group. A restriction analysis was carried out with AluI and EcoRI to confirm that the five sequences belongs to subgroup D. The rest of the sequences did not exhibit any known RFLP profile related to a subgroup reported in the 16SrXIII group.

Relative ion expansion velocity in laser-produced plasmas

NASA Technical Reports Server (NTRS)

Goldsmith, S.; Moreno, J. C.; Griem, H. R.; Cohen, Leonard; Richardson, M. C.

1988-01-01

The spectra of highly ionized titanium, Ti XIII through Ti XXI, and C VI Lyman lines were excited in laser-produced plasmas. The plasma was produced by uniformly irradiating spherical glass microballoons coated with thin layers of titanium and parylene. The 24-beam Omega laser system produced short, 0.6 ns, and high-intensity, 4 x 10 to the 14th W/sq cm, laser pulses at a wavelength of 351 nm. The measured wavelength for the 2p-3s Ti XIII resonance lines had an average shift of + 0.023 A relative to the C VI and Ti XX spectral lines. No shift was found between the C VI, Ti XIX, and Ti XX lines. The shift is attributed to a Doppler effect, resulting from a difference of (2.6 + or - 0.2) x 10 to the 7th cm/s in the expansion velocities of Ti XIX and Ti XX ions compared to Ti XIII ions.

Plasma deposition of antimicrobial coating on organic polymer

NASA Astrophysics Data System (ADS)

Rżanek-Boroch, Zenobia; Dziadczyk, Paulina; Czajkowska, Danuta; Krawczyk, Krzysztof; Fabianowski, Wojciech

2013-02-01

Organic materials used for packing food products prevent the access of microorganisms or gases, like oxygen or water vapor. To prolong the stability of products, preservatives such as sulfur dioxide, sulfites, benzoates, nitrites and many other chemical compounds are used. To eliminate or limit the amount of preservatives added to food, so-called active packaging is sought for, which would limit the development of microorganisms. Such packaging can be achieved, among others, by plasma modification of a material to deposit on its surface substances inhibiting the growth of bacteria. In this work plasma modification was carried out in barrier discharge under atmospheric pressure. Sulfur dioxide or/and sodium oxide were used as the coating precursors. As a result of bacteriological studies it was found that sulfur containing coatings show a 16% inhibition of Salmonella bacteria growth and 8% inhibition of Staphylococcus aureus bacteria growth. Sodium containing coatings show worse (by 10%) inhibiting properties. Moreover, films with plasma deposited coatings show good sealing properties against water vapor. Contribution to the Topical Issue "13th International Symposium on High Pressure Low Temperature Plasma Chemistry (Hakone XIII)", Edited by Nicolas Gherardi, Henryca Danuta Stryczewska and Yvan Ségui.

A comparison of the mechanical, kinetic, and biochemical properties of fibrin clots formed with two different fibrin sealants.

PubMed

Hickerson, William L; Nur, Israel; Meidler, Roberto

2011-01-01

The objective of the present study was to compare the mechanical, kinetic, and biochemical properties of fibrin clots produced using EVICEL Fibrin Sealant (Human) and TISSEEL Fibrin Sealant. The stiffness/elasticity and strength of fibrin clots formed with EVICEL and TISSEEL were assessed using applied mechanical force and thromboelastography (TEG). The factor XIII content of the fibrin clots was also evaluated. Mean Young modulus and tensile strength of the fibrin clots produced by EVICEL were significantly higher than those of clots produced by TISSEEL (P < 0.05 for both). The mean time to initial clot formation and mean time to the predefined level of clot formation were numerically shorter for EVICEL compared with TISSEEL. Furthermore, mean maximal amplitude of the clots formed with EVICEL was significantly greater than that for the clots formed with TISSEEL. Mean concentration of factor XIII for the EVICEL fibrinogen samples tested was 9 IU/ml compared with undetectable concentrations of factor XIII for the TISSEEL fibrinogen samples. Fibrin clots formed with EVICEL have a much higher resistance to stretching and tensile strength and are more capable of maintaining their structure against applied force than those formed with TISSEEL. EVICEL also allows more rapid development of fibrin clots than TISSEEL. This superior clot strength and resilience obtained with EVICEL relative to TISSEEL may be due in large part to the presence of factor XIII.

Feasibility Study for a Structurally Efficient, Multi-Modal Shelter Concept Utilizing Advanced Technology Production Techniques

DTIC Science & Technology

1974-02-01

II I~ x p:1 ns ion P roc cuurc Longitudin:-11 Section, Container Mod·c Configuration r Ex p :m s i on Pro c c d u r e Longitudinal Section...No . I II. I I I. IV. v. VI. VII. VIII. IX. X . XI. XII. XIII. XIV. XV . XVI. XVII . XVIII . XIX. XX. XXI. XXII . XXI II. XXIV...mat e rial s and examples from these categories . Glass Fibers Glass Mi c r os pheres As bestos Carbon Graphite Ce llulose Cotton Jute Rayo n

Raman spectroscopic study of hydrogen ordered ice XIII and of its reversible phase transition to disordered ice V.

PubMed

Salzmann, Christoph G; Hallbrucker, Andreas; Finney, John L; Mayer, Erwin

2006-07-14

Raman spectra of recovered ordered H(2)O (D(2)O) ice XIII doped with 0.01 M HCl (DCl) recorded in vacuo at 80 K are reported in the range 3600-200 cm(-1). The bands are assigned to the various types of modes on the basis of isotope ratios. On thermal cycling between 80 and 120 K, the reversible phase transition to disordered ice V is observed. The remarkable effect of HCl (DCl) on orientational ordering in ice V and its phase transition to ordered ice XIII, first reported in a powder neutron diffraction study of DCl doped D(2)O ice V (C. G. Salzmann, P. G. Radaelli, A. Hallbrucker, E. Mayer, J. L. Finney, Science, 2006, 311, 1758), is demonstrated by Raman spectroscopy and discussed. The dopants KOH and HF have only a minor effect on hydrogen ordering in ice V, as shown by the Raman spectra.

Tabulation of comet observations.

NASA Astrophysics Data System (ADS)

Concerning comets: 1962 VIII Humason, 1971 V Toba, 1975 XI Bradfield, 1979 X Bradfield, 1980 X P/Stephan-Oterma, 1980 XI P/Encke, 1980 XIII P/Tuttle, 1981 II Panther, 1982 VI Austin, 1982 VIII P/Churyumov-Gerasimenko, 1983 V Sugano-Saigusa-Fujikawa, 1983 VII IRAS-Araki-Alcock, 1983 XIII P/Kopff, 1984 III P/Hartley-IRAS, 1985 XIII P/Giacobini-Zinner, 1985 XVII Hartley-Good, 1985 XIX Thiele, 1986 III P/Halley, 1986h P/Schwassmann-Wachmann 2, 1986j P/Comas Solá, 1986k P/Kohoutek, 1986l Wilson, 1986m P/Grigg-Skjellerup, 1986n Sorrells, 1987h P/Howell, 1987l P/Reinmuth 2, 1987m P/Brooks 2, 1987n P/Harrington, 1987p P/Borrelly, 1987r P/Reinmuth 1, 1987s Bradfield, 1987u Rudenko, 1987y Levy, 1987z P/Shoemaker-Holt, 1987b1 McNaught, 1987d1 Ichimura, 1987f1 Furuyama, 1988a Liller, 1988b Shoemaker, 1988c Maury-Phinney, 1988e Levy, P/Schwassmann-Wachmann 1.

Diagnosis, clinical manifestations and management of rare bleeding disorders in Iran.

PubMed

Dorgalaleh, Akbar; Alavi, Sayed Ezatolla Rafiee; Tabibian, Shadi; Soori, Shahrzad; Moradi, Es'hagh; Bamedi, Taregh; Asadi, Mansour; Jalalvand, Masumeh; Shamsizadeh, Morteza

2017-05-01

Rare bleeding disorders (RBDs) are heterogeneous disorders, mostly inherited in an autosomal recessive pattern. Iran is a Mideast country with a high rate of consanguinity that has a high rate of RBDs. In this study, we present prevalence and clinical presentation as well as management and genetic defects of Iranian patients with RBDs. For this study, all relevant publications were searched in Medlin until 2015. Iran has the highest global incidence of factor XIII deficiency. Factor VII deficiency also is common in Iran, while factor II deficiency, with a prevalence of 1 per ∼3 million, is the rarest form of RBDs. Factor activity is available for all RBDs except for factor XIII deficiency, in which clot solubility remains as a diagnostic test. Molecular analysis of Iranian patients with RBDs revealed a few recurrent, common mutations only in patients with factor XIII deficiency, and considerable novel mutations in other RBDs. Clinical manifestations of these patients are variable and patients with factor XIII, factor X and factor VII more commonly presented severe life-threatening bleeding, while patients with combined factor V and factor VIII presented a milder phenotype. Plasma-derived products are the most common therapeutic choice in Iran, used prophylactically or on-demand for the management of these patients. Since Iran has a high rate of RBDs with life-threatening bleeding, molecular studies can be used for carrier detection and, therefore, prevention of the further expansion of these disorders and their fatal consequence.

Artesanias Mexico - Americanas. Programa Piloto de Entrenamiento Para El Asociado Bilingue y Bicultural En El Desarrollo del Nino: Guia XIII [Arts and Crafts of Mexico and the Americas. Pilot Program for the Training of Bilingual and Bicultural Teachers for the Cognitive Development of the Child: Guide XIII].

ERIC Educational Resources Information Center

de Celis, Margarita

This Child Development Associate (CDA) training module, the thirteenth in a series of 16, provides creative experiences with arts and crafts for young children. Designed for preschool teachers and paraprofessional trainees, the Spanish text offers a variety of craft activities. A list of materials necessary, step-by-step directions and…

Powertrain Test Procedure Development for EPA GHG Certification of Medium- and Heavy-Duty Engines and Vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chambon, Paul H.; Deter, Dean D.

2016-07-01

xiii ABSTRACT The goal of this project is to develop and evaluate powertrain test procedures that can accurately simulate real-world operating conditions, and to determine greenhouse gas (GHG) emissions of advanced medium- and heavy-duty engine and vehicle technologies. ORNL used their Vehicle System Integration Laboratory to evaluate test procedures on a stand-alone engine as well as two powertrains. Those components where subjected to various drive cycles and vehicle conditions to evaluate the validity of the results over a broad range of test conditions. Overall, more than 1000 tests were performed. The data are compiled and analyzed in this report.

Free factor XIII activation peptide (fAP-FXIII) is a regulator of factor XIII activity via factor XIII-B.

PubMed

Dodt, Johannes; Pasternack, Ralf; Seitz, Rainer; Volkers, Peter

2016-02-01

In a factor XIIIa (FXIIIa) generation assay with recombinant FXIII-A2 (rFXIII-A2 ) free FXIII activation peptide (fAP-FXII) prolonged the time to peak (TTP) but did not affect the area under the curve (AUC) or concentration at peak (CP). Addition of recombinant factorXIII-B2 (rFXIII-B2 ) restored the characteristics of the FXIIIa generation parameters (AUC, TTP and CP) to those observed for plasma FXIII (FXIII-A2 B2 ). FXIII-A2 B2 reconstituted from rFXIII-A2 and rFXIII-B2 showed a similar effect on AUC, TTP and CP in the presence of fAP-FXII as observed for plasma FXIII-A2 B2 , indicating a role for FXIII-B in this observation. An effect of fAP-FXIII on thrombin, the proteolytic activator of FXIII, was excluded by thrombin generation assays and clotting experiments. In a purified system, fAP-FXIII did not interfere with the FXIIIa activity development of thrombin-cleaved rFXIII-A2 (rFXIII-A2 ') also excluding direct inhibition of FXIIIa. However, FXIIIa activity development of FXIII-A2 'B2 was inhibited in a concentration-dependent manner by fAP-FXIII, indicating that an interaction between AP-FXIII and FXIII-B2 contributes to the overall stability of FXIII-A2 'B2 . In addition to its well-known role, FXIII-B also contributes to FXIII-A2 B2 stability or dissociation depending on fAP-FXIII and calcium concentrations. © 2015 John Wiley & Sons Ltd.

Modern and prospective technologies for weather modification activities: A look at integrating unmanned aircraft systems

NASA Astrophysics Data System (ADS)

Axisa, Duncan; DeFelice, Tom P.

2016-09-01

Present-day weather modification technologies are scientifically based and have made controlled technological advances since the late 1990s, early 2000s. The technological advances directly related to weather modification have primarily been in the decision support and evaluation based software and modeling areas. However, there have been some technological advances in other fields that might now be advanced enough to start considering their usefulness for improving weather modification operational efficiency and evaluation accuracy. We consider the programmatic aspects underlying the development of new technologies for use in weather modification activities, identifying their potential benefits and limitations. We provide context and initial guidance for operators that might integrate unmanned aircraft systems technology in future weather modification operations.

Energy Levels and Radiative Rates for Transitions in F-like Sc XIII and Ne-like Sc XII and Y XXX

NASA Astrophysics Data System (ADS)

Aggarwal, Kanti

2018-05-01

Energy levels, radiative rates and lifetimes are reported for F-like Sc~XIII and Ne-like Sc~XII and Y~XXX for which the general-purpose relativistic atomic structure package ({\\sc grasp}) has been adopted. For all three ions limited data exist in the literature but comparisons have been made wherever possible to assess the accuracy of the calculations. In the present work the lowest 102, 125 and 139 levels have been considered for the respective ions. Additionally, calculations have also been performed with the flexible atomic code ({\\sc fac}) to (particularly) confirm the accuracy of energy levels.

Aerodynamic Design of Axial-flow Compressors. Volume III

NASA Technical Reports Server (NTRS)

Johnson, Irving A; Bullock, Robert O; Graham, Robert W; Costilow, Eleanor L; Huppert, Merle C; Benser, William A; Herzig, Howard Z; Hansen, Arthur G; Jackson, Robert J; Yohner, Peggy L;

Newly-recognized roles of factor XIII in thrombosis

PubMed Central

Byrnes, James R.; Wolberg, Alisa S.

2017-01-01

Arterial and venous thrombosis are major contributors to coagulation-associated morbidity and mortality. Greater understanding of mechanisms leading to thrombus formation and stability is expected to lead to improved treatment strategies. Factor XIII (FXIII) is a transglutaminase found in plasma and platelets. During thrombosis, activated FXIII crosslinks fibrin and promotes thrombus stability. Recent studies have provided new information about FXIII activity during coagulation and its effects on clot composition and function. These findings reveal newly-recognized roles for FXIII in thrombosis. Herein, we review published literature on FXIII biology and effects on fibrin structure and stability, epidemiologic data associating FXIII with thrombosis, and evidence from animal models indicating FXIII has an essential role in determining thrombus stability, composition, and size. PMID:27056150

Local dynamics measured by hydrogen/deuterium exchange and mass spectrometry of creatine kinase digested by two proteases.

PubMed

Mazon, Hortense; Marcillat, Olivier; Forest, Eric; Vial, Christian

2005-12-01

Hydrogen/deuterium exchange coupled to mass spectrometry has been used to investigate the structure and dynamics of native dimeric cytosolic muscle creatine kinase. The protein was incubated in D2O for various time. After H/D exchange and rapid quenching of the reaction, the partially deuterated protein was cleaved in parallel by two different proteases (pepsin or type XIII protease from Aspergillus saitoi) to increase the sequence coverage and spatial resolution of deuterium incorporation. The resulting peptides were analyzed by liquid chromatography coupled to mass spectrometry. In comparison with the 3D structure of MM-CK, the analysis of the two independent proteolysis deuteration patterns allowed us to get new insights into CK local dynamics as compared to a previous study using pepsin [Mazon et al. Protein Science 13 (2004) 476-486]. In particular, we obtained more information on the kinetics and extent of deuterium exchange in the N- and C-terminal extremities represented by the 1-22 and 362-380 pepsin peptides. Indeed, we observed a very different behaviour of the 1-12 and 13-22 type XIII protease peptides, and similarly for the 362-373 and 374-380 peptides. Moreover, comparison of the deuteration patterns of type XIII protease segments of the large 90-126 pepsin peptide led us to identify a small relatively dynamic region (108-114).

Clot retraction is mediated by factor XIII-dependent fibrin-αIIbβ3-myosin axis in platelet sphingomyelin-rich membrane rafts.

PubMed

Kasahara, Kohji; Kaneda, Mizuho; Miki, Toshiaki; Iida, Kazuko; Sekino-Suzuki, Naoko; Kawashima, Ikuo; Suzuki, Hidenori; Shimonaka, Motoyuki; Arai, Morio; Ohno-Iwashita, Yoshiko; Kojima, Soichi; Abe, Mitsuhiro; Kobayashi, Toshihide; Okazaki, Toshiro; Souri, Masayoshi; Ichinose, Akitada; Yamamoto, Naomasa

2013-11-07

Membrane rafts are spatially and functionally heterogenous in the cell membrane. We observed that lysenin-positive sphingomyelin (SM)-rich rafts are identified histochemically in the central region of adhered platelets where fibrin and myosin are colocalized on activation by thrombin. The clot retraction of SM-depleted platelets from SM synthase knockout mouse was delayed significantly, suggesting that platelet SM-rich rafts are involved in clot retraction. We found that fibrin converted by thrombin translocated immediately in platelet detergent-resistant membrane (DRM) rafts but that from Glanzmann's thrombasthenic platelets failed. The fibrinogen γ-chain C-terminal (residues 144-411) fusion protein translocated to platelet DRM rafts on thrombin activation, but its mutant that was replaced by A398A399 at factor XIII crosslinking sites (Q398Q399) was inhibited. Furthermore, fibrin translocation to DRM rafts was impaired in factor XIII A subunit-deficient mouse platelets, which show impaired clot retraction. In the cytoplasm, myosin translocated concomitantly with fibrin translocation into the DRM raft of thrombin-stimulated platelets. Furthermore, the disruption of SM-rich rafts by methyl-β-cyclodextrin impaired myosin activation and clot retraction. Thus, we propose that clot retraction takes place in SM-rich rafts where a fibrin-αIIbβ3-myosin complex is formed as a primary axis to promote platelet contraction.

[Best time to administer coagulation factor XIII( Fibrogammin P) for postoperative intractable pancreatic fistula following gastrectomy for gastric cancer].

PubMed

Shoda, Katsutoshi; Komatsu, Shuhei; Ichikawa, Daisuke; Kubota, Takeshi; Okamoto, Kazuma; Arita, Tomohiro; Konishi, Hirotaka; Murayama, Yasutoshi; Shiozaki, Atsushi; Kuriu, Yoshiaki; Ikoma, Hisashi; Nakanishi, Masayoshi; Fujiwara, Hitoshi; Otsuji, Eigo

2013-11-01

Coagulation factor XIII( Fibrogammin P, F XIII) has been used to treat postoperative pancreatic fistulas following gastrectomy for gastric cancer in Japan. However, little is known about the best timing to start this treatment for early recovery. This study was designed to examine the appropriate time to start Fibrogammin P treatment for pancreatic fistulas, based on nutritional and inflammatory parameters. We retrospectively examined 27 consecutive patients with Grade B or C pancreatic fistulas as defined by the International Study Group of Pancreatic Fistula( ISGPF) classification who underwent gastrectomy at our institute between 1997 and 2011. We analyzed data on total protein( TP), albumin (Alb), C-reactive protein( CRP), and hemoglobin( Hb) concentrations and white blood cell( WBC) and lymphocyte counts. We used this information to determine laboratory cut-off values that indicate the most advantageous time to start the administration of Fibrogammin P in order to achieve early recovery within 2 weeks. When Fibrogammin P administration was based on more than 2 cut-off values such as Alb>2.6 g/dL and Hb>9.0 g/dL and WBC<9,000/μL (p= 0.1563), early cure of pancreatic fistulas was achieved. The use of nutritional and inflammatory parameter values to determine the best time to administer Fibrogammin P may shorten the treatment period.

FE-XIII Infrared / FE-XIV Green Line Ratio Diagnostics (P55)

NASA Astrophysics Data System (ADS)

Srivastava, A. K.; et al.

2006-11-01

aks.astro.itbhu@gmail.com We consider the first 27-level atomic model of Fe XIII (5.9 < log Te < 6.4 K) to estimate its ground level populations, taking account of electron as well as proton collisional excitations and de-excitations, radiative cascades, radiative excitations and de-excitations. Radiative cascade is important but the effect of dilution factor is negligible at higher electron densities. The 3 P1-3P0 and 3P2-3P1 transitions in the ground configuration 3s2 3p2 of Fe XIII result in two forbidden coronal emission lines in the infrared region, namely 10747 Å and 10798 Å., while the 5303 Å green line is formed in the 3s2 3p 2 2 ground configuration of Fe XIV as a result of P3 / 2 - P1 / 2 magnetic dipole transition. The line-widths of appropriate pair of forbidden coronal emission lines observed simultaneously can be useful diagnostic tool to deduce temperature and non-thermal velocity in the large scale coronal structures using intensity ratios of the lines as the temperature signature, instead of assuming ion temperature to be equal to the electron temperature. Since the line intensity ratios IG5303/IIR10747 and IG5303/IIR10798 have very week density dependence, they are ideal monitors of temperature mapping in the solar corona.

Genome Modification Technologies and Their Applications in Avian Species.

PubMed

Lee, Hong Jo; Kim, Young Min; Ono, Tamao; Han, Jae Yong

2017-10-26

The rapid development of genome modification technology has provided many great benefits in diverse areas of research and industry. Genome modification technologies have also been actively used in a variety of research areas and fields of industry in avian species. Transgenic technologies such as lentiviral systems and piggyBac transposition have been used to produce transgenic birds for diverse purposes. In recent years, newly developed programmable genome editing tools such as transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) have also been successfully adopted in avian systems with primordial germ cell (PGC)-mediated genome modification. These genome modification technologies are expected to be applied to practical uses beyond system development itself. The technologies could be used to enhance economic traits in poultry such as acquiring a disease resistance or producing functional proteins in eggs. Furthermore, novel avian models of human diseases or embryonic development could also be established for research purposes. In this review, we discuss diverse genome modification technologies used in avian species, and future applications of avian biotechnology.

Genome Modification Technologies and Their Applications in Avian Species

PubMed Central

Lee, Hong Jo; Kim, Young Min; Ono, Tamao

2017-01-01

The rapid development of genome modification technology has provided many great benefits in diverse areas of research and industry. Genome modification technologies have also been actively used in a variety of research areas and fields of industry in avian species. Transgenic technologies such as lentiviral systems and piggyBac transposition have been used to produce transgenic birds for diverse purposes. In recent years, newly developed programmable genome editing tools such as transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) have also been successfully adopted in avian systems with primordial germ cell (PGC)-mediated genome modification. These genome modification technologies are expected to be applied to practical uses beyond system development itself. The technologies could be used to enhance economic traits in poultry such as acquiring a disease resistance or producing functional proteins in eggs. Furthermore, novel avian models of human diseases or embryonic development could also be established for research purposes. In this review, we discuss diverse genome modification technologies used in avian species, and future applications of avian biotechnology. PMID:29072628

77 FR 68155 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

...-Quality Control Compliance/3rd Party CPA XII. National Foreclosure Mitigation Counseling (NFMC) Compliance Update XIII. OHTS Watch List and Overview of Organizational Assessment Review Process XIV. Adjournment...

32 CFR 865.114 - Decisional document.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Awards and decorations. (ix) Educational level. (x) Aptitude test scores. (xi) Incidents of punishment... punishment). (xii) Conviction by court-martial. (xiii) Prior military service and type of discharge received...

32 CFR 865.114 - Decisional document.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Awards and decorations. (ix) Educational level. (x) Aptitude test scores. (xi) Incidents of punishment... punishment). (xii) Conviction by court-martial. (xiii) Prior military service and type of discharge received...

32 CFR 865.114 - Decisional document.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Awards and decorations. (ix) Educational level. (x) Aptitude test scores. (xi) Incidents of punishment... punishment). (xii) Conviction by court-martial. (xiii) Prior military service and type of discharge received...

32 CFR 865.114 - Decisional document.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Awards and decorations. (ix) Educational level. (x) Aptitude test scores. (xi) Incidents of punishment... punishment). (xii) Conviction by court-martial. (xiii) Prior military service and type of discharge received...

Department of Transportation Agency Semiannual Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

... [The Regulatory Plan and Unified Agenda of Federal Regulatory and Deregulatory Actions] [Department of Transportation Agency Semiannual Regulatory Agenda ] Part XIII Department of Transportation Semiannual Regulatory Agenda [[Page 79812

A Nonparametric Approach to Segmentation of Ladar Images

DTIC Science & Technology

2012-12-01

82 5.3.4 Simulation ...91 6.2.1 Multi-Facet Board Simulation ...Pulse spreading effects are ignored. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 xiii Figure Page 5.4. Signal pulse energy with

Simulation of Aircraft Sortie Generation Under an Autonomic Logistics System

DTIC Science & Technology

2016-12-01

56 Design of Experiment...Figure 8. Pre -flight Operations ......................................................................................... 40 Figure 9. Sortie...Critical Factors and Their Associated Levels ................................................... 57 xiii Table 18. Design of Experiment

Accessing Synthetically-Challenging Isoindole-Based Materials for Assessment in Organic Photovoltaics via Chemical and Engineering Methodologies =

NASA Astrophysics Data System (ADS)

Dang, Jeremy

Isoindoles are a broad class of compounds that comprise a very small space within the domain of established photoactive materials for organic photovoltaics (OPVs). Given this scarcity, combined with the performance appeal of presently and well known isoindole-based compounds such as the phthalocyanines, it is a worthy undertaking to develop new materials in this domain. This thesis aims to bring to light the suitability of five novel, or underexplored, classes of isoindole-based materials for OPVs. These classes are the boron subphthalocyanine (BsubPc) polymers, oxygen-bridged dimers of BsubPcs (mu-oxo-(BsubPc) 2), boron subnaphthalocyanines (BsubNcs), group XIII metal complexes of 1,3-bis(2-pyridylimino)isodinoline (BPI), and the boron tribenzosubporphyrins (BsubPys). The synthesis of these materials was proven to be challenging as evident in their low isolated yields, lengthy synthetic and purification processes, and/or batch-to-batch variations. This outcome was not surprising given their undeveloped chemical nature. The photo- and electro-physical properties were characterized and shown to be desirable for all classes other than the group XIII metal complexes of BPI for OPVs. mu-Oxo-(BsubPc)2 and BsubNcs show promise in this application while BsubPc polymers and BsubPys will be subjects of future exploration. The results from the work herein aid to develop and strengthen the fundamental understanding of the structure-property relationships of isoindole derivatives. On a broader scale, the work demonstrates their versatility as functional materials for OPVs and their possible expansion to other organic electronic technologies like organic light emitting diodes and organic field effect transistors.

49 CFR 1572.103 - Disqualifying criminal offenses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... controlled substance. (viii) Arson. (ix) Kidnapping or hostage taking. (x) Rape or aggravated sexual abuse. (xi) Assault with intent to kill. (xii) Robbery. (xiii) Fraudulent entry into a seaport as described...

49 CFR 1572.103 - Disqualifying criminal offenses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... controlled substance. (viii) Arson. (ix) Kidnapping or hostage taking. (x) Rape or aggravated sexual abuse. (xi) Assault with intent to kill. (xii) Robbery. (xiii) Fraudulent entry into a seaport as described...

Book review: Rogue waves in the ocean

USGS Publications Warehouse

Geist, Eric L.

2011-01-01

Review info: Rogue Waves in the Ocean. Advances in Geophysical and Environmental Mechanics and Mathematics. By Christian Kharif, Efim Pelinovsky and Alexey Slunyaev, 2009. ISBN: 978-3540884187, xiii, 216 pp.

19 CFR 122.183 - Denial of access.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) Destruction of an aircraft or aircraft facility (18 U.S.C. 32); (xiii) Murder; (xiv) Assault with intent to murder; (xv) Espionage; (xvi) Sedition; (xvii) Kidnapping or hostage taking; (xviii) Treason; (xix) Rape...

19 CFR 122.183 - Denial of access.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) Destruction of an aircraft or aircraft facility (18 U.S.C. 32); (xiii) Murder; (xiv) Assault with intent to murder; (xv) Espionage; (xvi) Sedition; (xvii) Kidnapping or hostage taking; (xviii) Treason; (xix) Rape...

Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides.

PubMed

Supuran, Claudiu T

2008-01-01

The widely clinically used benzothiadiazines and high ceiling diuretics, such as hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide, contain SO(2)NH(2) moieties acting as an effective zinc-binding function in carbonic anhydrases (CAs, EC 4.2.1.1) inhibitors. These drugs were launched in a period when only isoform CA II was known and considered physiologically/pharmacologically relevant. Although acting as moderate-weak inhibitors of CA II, all these drugs considerably inhibit other CA isozymes known nowadays to be involved in critical physiologic processes, among the 16 CAs present in vertebrates. Some low nanomolar (or even subnanomolar) inhibitors against such isoforms were recently detected, such as metholazone against CA VII, XII and XIII, chlorthalidone against CA VB, VII, IX, XII and XIII, indapamide against CA VII, IX, XII and XIII, furosemide against CA I, II and XIV, and bumethanide against CA IX and XII. The X-ray crystal structure of the CA II-indapamide adduct was also reported recently, revealing interesting aspects useful for the drug design of CA inhibitors. It has also been proposed that the recently observed beneficial effect of indapamide for the treatment of patients with hypertension and type 2 diabetes might be due to its potent inhibition of CA isoforms present in kidneys and blood vessels, which would thus explain both the blood pressure lowering effects as well as organ-protective activity of the drug. Thus, these old drugs may be useful as leads for new applications.

Order XIII. Pseudonocardineae ord.nov.

USDA-ARS?s Scientific Manuscript database

The formal description of the actinobacterial higher taxon, the suborder Pseudonocardineae, is presented. The differential morphological and chemotaxonomic characteristics and diagnostic signature nucleotides from the 16S rRNA gene for the families Actinosynnemataceae and Pseudonocardiaceae in the ...

77 FR 29648 - Medicare and Medicaid Programs; Quarterly Listing of Program Issuances-January Through March 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

... (Destination Therapy) Facilities. XIII Medicare-Approved Lung Volume Reduction Surgery JoAnna Baldwin, MS (410) 786-7205 Facilities. XIV Medicare-Approved Bariatric Surgery Facilities........ Kate Tillman, RN, MAS...

16 CFR 4.9 - The public record.

Code of Federal Regulations, 2010 CFR

2010-01-01

... to § 305.8 of this chapter; (xiii) Annual filings by professional boxing sanctioning organizations as required by the Muhammed Ali Boxing Reform Act, 15 U.S.C. 6301 note, 6307a-6307h; (xiv) Other documents...

An experimental approach to manufacturing technology of historical glass (XIII-XV centuries). Comparison with current glassmaking technology.

NASA Astrophysics Data System (ADS)

Tarrago, Mariona; Gimeno, Domingo; Bazzocchi, Flavia; Garcia-Valles, Maite; Martinez, Salvador

2015-04-01

One of the major and less explored issues in the characterization of historical glasses is the determination of their viscosity as a function of temperature in order to constrain technological aspects of glass production. Until now, assumptions on temperatures have been based on mathematical models based on chemical compositions. Hence, the topic of this work is to explore the technology of stained glass production related to the workability and melting process of the glass by experimental laboratory measurements. This work presents the analysis of viscosity of glasses from different historical sites and chemical compositions: four from Santes Creus (Tarragona, XIII century), two of classical medieval stained glass window from Santa Maria de Pedralbes (Barcelona, mid XIV century), and three of evolved late-medieval type from Santa Maria del Mar (Barcelona first half of XV century), and one sample of soda-lime industrial glass by means of Hot-Stage Microscopy and glass transformation temperature Tg by dilatometry. These data are then compared to the predictions on theoretical viscosity obtained from mathematical models based on chemical composition. These samples are classified according to their major modifier in: Na-rich (12-17% of Na2O, between 65-77% of SiO2 and less than 3 % of K2O); Ca-rich (29% of CaO, 54% of SiO2, 4% of K2O, and 4% of Na2O); K-Ca-rich (17 to 21% of K2O, more than 14% of CaO, 49-55% of SiO2and less than 2% of Na2O); Na-Ca-rich (12-14% of Na2O, 9-15% of CaO, 57-71% of SiO2 and < 6% of K2O). Glass transition temperature (Tg) is correlated to chemical composition: 464-492 °C for Na-rich, 645 °C for Ca-rich, 582-586 °C for K-Ca-rich and 497-542 °C for Na-Ca-rich glasses. Experimental viscosity-temperature curves are traced using Tg and fixed viscosity points measured by Hot-Stage microscopy (according to German standard 51730) in order to provide more accurate insight into the phases of glass production process (melting, working, conditioning and annealing ranges). These results are also compared to mathematical models of glass viscosity based on chemical composition. The annealing range (viscosity between 1013.5 and 1012 Pa-s) is reached at temperatures between 484-633°C (strain point) and 509-664°C (upper limit). The working point (viscosity of 103 Pa-s) has temperature values in the range between 958 and 1097°C.

Traditional and New Enhancing Human Cybernetic and Nanotechnological Body Modification Technologies: A Comparative Study of Roman Catholic and Transhumanist Ethical Approaches

NASA Astrophysics Data System (ADS)

Caligiuri, Michael J.

Advances in cybernetic and nanotechnological body modifications currently allow for enhancements to human physical and mental function which exceed human species-based norms. This thesis examines body modification and human enhancement from two perspectives---Roman Catholicism and Transhumanism--- in order to contribute to bioethical deliberations regarding enhancement technologies. Roman Catholicism has a longstanding tradition of bioethical discourse, informing the healthcare directives of Roman Catholic institutions. Transhumanism is more recent movement that endorses body modifications and human enhancements as a means of individual betterment and social evolution. The thesis first considers definitions of human enhancement and levels of normalcy in connection to cybernetic and nanotechnological bionic implants, and outlines a series of criteria to assess a technology's potential bioethical acceptability: implantability, permanency, power, and public interaction. The thesis then describes Roman Catholicism's response to non-enhancing decorative body modifications (cosmetic surgeries, common decorative modifications such as tattoos and piercings, and uncommon modifications such as scarifications and brandings) in order to establish a basis for possible Roman Catholic responses to enhancing cybernetic and nanotechnological modifications. This is followed by an analysis from a Roman Catholic perspective of the major social issues brought forward by enhancement technologies: commodification, eugenics, vulnerability, and distributive justice. Turning to Transhumanism, the thesis describes the origins and philosophy of the movement, and then discusses the bioethical principles it advances with regard to human enhancement. The thesis concludes by locating points of convergence between Transhumanism and Roman Catholicism that could be the basis of more widely accepted ethical guidelines regarding modification technologies.

Diagnosing the Magnetic Field Structure of a Coronal Cavity Observed during the 2017 Total Solar Eclipse

NASA Astrophysics Data System (ADS)

Chen, Yajie; Tian, Hui; Su, Yingna; Qu, Zhongquan; Deng, Linhua; Jibben, Patricia R.; Yang, Zihao; Zhang, Jingwen; Samanta, Tanmoy; He, Jiansen; Wang, Linghua; Zhu, Yingjie; Zhong, Yue; Liang, Yu

2018-03-01

We present an investigation of a coronal cavity observed above the western limb in the coronal red line Fe X 6374 Å using a telescope of Peking University and in the green line Fe XIV 5303 Å using a telescope of Yunnan Observatories, Chinese Academy of Sciences, during the total solar eclipse on 2017 August 21. A series of magnetic field models is constructed based on the magnetograms taken by the Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory (SDO) one week before the eclipse. The model field lines are then compared with coronal structures seen in images taken by the Atmospheric Imaging Assembly on board SDO and in our coronal red line images. The best-fit model consists of a flux rope with a twist angle of 3.1π, which is consistent with the most probable value of the total twist angle of interplanetary flux ropes observed at 1 au. Linear polarization of the Fe XIII 10747 Å line calculated from this model shows a “lagomorphic” signature that is also observed by the Coronal Multichannel Polarimeter of the High Altitude Observatory. We also find a ring-shaped structure in the line-of-sight velocity of Fe XIII 10747 Å, which implies hot plasma flows along a helical magnetic field structure, in the cavity. These results suggest that the magnetic structure of the cavity is a highly twisted flux rope, which may erupt eventually. The temperature structure of the cavity has also been investigated using the intensity ratio of Fe XIII 10747 Å and Fe X 6374 Å.

THERMAL STRUCTURE OF CORONAL LOOPS AS SEEN WITH NORIKURA CORONAGRAPH

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prasad, S. Krishna; Singh, Jagdev; Ichimoto, K., E-mail: krishna@iiap.res.in

2013-03-10

The thermal structure of a coronal loop, both along and across the loop, is vital in determining the exact plasma heating mechanism. High-resolution spectroscopic observations of the off-limb corona were made using the 25 cm Norikura coronagraph, located at Norikura, Japan. Observations on a number of days were made simultaneously in four forbidden iron emission lines, namely, the [Fe XI] 7892 A line, the [Fe XIII] 10747 A and 10798 A lines, and the [Fe XIV] 5303 A line and on some days made only in the [Fe XI] 7892 A and [Fe X] 6374 A lines. Using temperature sensitivemore » emission line ratios [Fe XIV] 5303 A/[Fe XIII] 10747 A and [Fe XI] 7892 A/[Fe X] 6374 A, we compute the electron temperatures along 18 different loop structures observed on different days. We find a significant negative temperature gradient in all of the structures observed in Fe XIV and Fe XIII and a positive temperature gradient in the structures observed in Fe XI and Fe X. Combining these results with the previous investigations by Singh and his collaborators, we infer that the loop tops, in general, appear hotter when observed in colder lines and colder when observed in relatively hotter lines as compared to their coronal foot points. We suggest that this contrasting trend observed in the temperature variation along the loop structures can be explained by a gradual interaction of different temperature plasma. The exact mechanism responsible for this interaction must be investigated further and has the potential to constrain loop heating models.« less

Design and Analysis of an Electron Gun/Booster and Free Electron Laser Optical Theory

DTIC Science & Technology

2010-09-01

42 23. Simplified cathode assembly model . . . . . . . . . . . . . . . . . . . . 45 24. Rossendorf and BNL RF chokes...225 123. Cross-correlation maps . . . . . . . . . . . . . . . . . . . . . . . . . . . 227 124. BNL SDL optical field...amplitude . . . . . . . . . . . . . . . . . . . . . 230 125. BNL SDL Gain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 230 xiii THIS

8 CFR 214.4 - Denial of certification, denial of recertification or withdrawal of SEVP certification.

Code of Federal Regulations, 2011 CFR

2011-01-01

...). (xii) Failure to operate as a bona fide institution of learning. (xiii) Failure to employ adequate...) Failure to maintain the physical plant, curriculum, and teaching staff in the manner represented in the...

77 FR 67368 - Medicare and Medicaid Programs; Quarterly Listing of Program Issuances-July through September 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-09

...) Facilities. XIII Medicare-Approved Lung JoAnna Baldwin, MS. (410) 786-7205 Volume Reduction Surgery Facilities. XIV Medicare-Approved Bariatric Kate Tillman, RN, (410) 786-9252 Surgery Facilities. MAS. XV...

Identifying and Analyzing Federal Government Market Opportunities for OpalSoft

DTIC Science & Technology

2004-09-01

OPPORTUNITIES, AND THREATS ( SWOT ) ANALYSIS......................................................................................13 1. Strengths...xiii LIST OF TABLES Table 1. SWOT Analysis...of industries to include Fortune 500 companies. Current key clients are Amkor, Symantec, Unisys Corporation, Apple Computers, Palm, Inc., and

26 CFR 1.897-5T - Corporate distributions (temporary).

Code of Federal Regulations, 2014 CFR

2014-04-01

... provided in section 897 and the regulations thereunder, except as provided by Articles XIII (9) and XXX (5... June 6, 1988. With regard to Article XXX (5) of the Income Tax Treaty with Canada, see, Rev. Rul. 85-76...

26 CFR 1.897-5T - Corporate distributions (temporary).

Code of Federal Regulations, 2011 CFR

2011-04-01

... provided in section 897 and the regulations thereunder, except as provided by Articles XIII (9) and XXX (5... June 6, 1988. With regard to Article XXX (5) of the Income Tax Treaty with Canada, see, Rev. Rul. 85-76...

26 CFR 1.897-5T - Corporate distributions (temporary).

Code of Federal Regulations, 2012 CFR

2012-04-01

... provided in section 897 and the regulations thereunder, except as provided by Articles XIII (9) and XXX (5... June 6, 1988. With regard to Article XXX (5) of the Income Tax Treaty with Canada, see, Rev. Rul. 85-76...

26 CFR 1.897-5T - Corporate distributions (temporary).

Code of Federal Regulations, 2013 CFR

2013-04-01

... provided in section 897 and the regulations thereunder, except as provided by Articles XIII (9) and XXX (5... June 6, 1988. With regard to Article XXX (5) of the Income Tax Treaty with Canada, see, Rev. Rul. 85-76...

42 CFR 88.1 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... sites in the respiratory system and intrathoracic organs. (xi) Mesothelioma. (xii) Malignant neoplasms of the peripheral nerves and autonomic nervous system, and other connective and soft tissue. (xiii... disorder means a chronic or recurrent disorder of the musculoskeletal system caused by heavy lifting or...

33 CFR 385.26 - Project Implementation Reports.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Implementation Report is a document that provides information on plan formulation and evaluation, engineering and..., environmental and/or economic benefits, engineering and design, costs, environmental impacts, real estate..., optimization and justification, cost-effectiveness, and engineering feasibility of the project; (xiii) Include...

26 CFR 1.897-5T - Corporate distributions (temporary).

Code of Federal Regulations, 2010 CFR

2010-04-01

... provided in section 897 and the regulations thereunder, except as provided by Articles XIII (9) and XXX (5... June 6, 1988. With regard to Article XXX (5) of the Income Tax Treaty with Canada, see, Rev. Rul. 85-76...

42 CFR 441.464 - State assurances.

Code of Federal Regulations, 2014 CFR

2014-10-01

... services, supports, and resources. (xii) Development of risk management agreements. (xiii) Development of... Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... protect the health and welfare of individuals furnished services under the program and to assure the...

42 CFR 441.464 - State assurances.

Code of Federal Regulations, 2012 CFR

2012-10-01

... services, supports, and resources. (xii) Development of risk management agreements. (xiii) Development of... Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... protect the health and welfare of individuals furnished services under the program and to assure the...

42 CFR 441.464 - State assurances.

Code of Federal Regulations, 2013 CFR

2013-10-01

... services, supports, and resources. (xii) Development of risk management agreements. (xiii) Development of... Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... protect the health and welfare of individuals furnished services under the program and to assure the...

Government and technological innovation - Weather modification as a case in point.

NASA Technical Reports Server (NTRS)

Lambright, W. H.

1972-01-01

The principal technology on which all forms of intentional, local weather modification ultimately rest is that of cloud seeding. There are three primary milestones in the evolution of such a new technology including invention, development, and introduction to society on an operational basis. It is shown that government has been deeply involved in each of the first two phases of weather modification's evolution. The agencies involved include the military agencies, the Weather Bureau, the National Science Foundation, and the Bureau of Reclamation. It is pointed out that weather modification will require some unusually flexible and open administrative devices if it is to advance in the public interest.

40 CFR 70.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

...: (i) Coal cleaning plants (with thermal dryers); (ii) Kraft pulp mills; (iii) Portland cement plants... plants; (xii) Phosphate rock processing plants; (xiii) Coke oven batteries; (xiv) Sulfur recovery plants...) totaling more than 250 million British thermal units per hour heat input; (xxii) Petroleum storage and...

40 CFR 71.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

...: (i) Coal cleaning plants (with thermal dryers); (ii) Kraft pulp mills; (iii) Portland cement plants... plants; (xii) Phosphate rock processing plants; (xiii) Coke oven batteries; (xiv) Sulfur recovery plants...) totaling more than 250 million British thermal units per hour heat input; (xxii) Petroleum storage and...

Agreement between factor XIII activity and antigen assays in measurement of factor XIII: A French multicenter study of 147 human plasma samples.

PubMed

Caron, C; Meley, R; Le Cam Duchez, V; Aillaud, M F; Lavenu-Bombled, C; Dutrillaux, F; Flaujac, C; Ryman, A; Ternisien, C; Lasne, D; Galinat, H; Pouplard, C

2017-06-01

Factor XIII (FXIII) deficiency is a rare hemorrhagic disorder whose early diagnosis is crucial for appropriate treatment and prophylactic supplementation in cases of severe deficiency. International guidelines recommend a quantitative FXIII activity assay as first-line screening test. FXIII antigen measurement may be performed to establish the subtype of FXIII deficiency (FXIIID) when activity is decreased. The aim of this multicenter study was to evaluate the analytical and diagnostic levels of performance of a new latex immunoassay, K-Assay ® FXIII reagent from Stago, for first-line measurement of FXIII antigen. Results were compared to those obtained with the Berichrom ® FXIII chromogenic assay for measurement of FXIII activity. Of the 147 patient plasma samples, 138 were selected for analysis. The accuracy was very good, with intercenter reproducibility close to 7%. Five groups were defined on FXIII activity level (<5% (n = 5), 5%-30% (n = 23), 30%-60% (n = 17), 60%-120% (n = 69), above 120% (n = 24)), without statistical differences between activity and antigen levels (P value >0.05). Correlation of the K-Assay ® with the Berichrom ® FXIII activity results was excellent (r = 0.919). Good agreement was established by the Bland and Altman method, with a bias of +9.4% on all samples, and of -1.4% for FXIII levels lower than 30%. One patient with afibrinogenemia showed low levels of Berichrom ® FXIII activity but normal antigen level and clot solubility as expected. The measurement of FXIII antigen using the K-Assay ® is a reliable first-line tool for detection of FXIII deficiency when an activity assay is not available. © 2017 John Wiley & Sons Ltd.

Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII

PubMed Central

Mattheij, Nadine J.A.; Swieringa, Frauke; Mastenbroek, Tom G.; Berny-Lang, Michelle A.; May, Frauke; Baaten, Constance C.F.M.J.; van der Meijden, Paola E.J.; Henskens, Yvonne M.C.; Beckers, Erik A.M.; Suylen, Dennis P.L.; Nolte, Marc W.; Hackeng, Tilman M.; McCarty, Owen J.T.; Heemskerk, Johan W.M.; Cosemans, Judith M.E.M.

2016-01-01

Coated platelets, formed by collagen and thrombin activation, have been characterized in different ways: i) by the formation of a protein coat of α-granular proteins; ii) by exposure of procoagulant phosphatidylserine; or iii) by high fibrinogen binding. Yet, their functional role has remained unclear. Here we used a novel transglutaminase probe, Rhod-A14, to identify a subpopulation of platelets with a cross-linked protein coat, and compared this with other platelet subpopulations using a panel of functional assays. Platelet stimulation with convulxin/thrombin resulted in initial integrin αIIbβ3 activation, the appearance of a platelet population with high fibrinogen binding, (independently of active integrins, but dependent on the presence of thrombin) followed by phosphatidylserine exposure and binding of coagulation factors Va and Xa. A subpopulation of phosphatidylserine-exposing platelets bound Rhod-A14 both in suspension and in thrombi generated on a collagen surface. In suspension, high fibrinogen and Rhod-A14 binding were antagonized by combined inhibition of transglutaminase activity and integrin αIIbβ3. Markedly, in thrombi from mice deficient in transglutaminase factor XIII, platelet-driven fibrin formation and Rhod-A14 binding were abolished by blockage of integrin αIIbβ3. Vice versa, star-like fibrin formation from platelets of a patient with deficiency in αIIbβ3 (Glanzmann thrombasthenia) was abolished upon blockage of transglutaminase activity. We conclude that coated platelets, with initial αIIbβ3 activation and high fibrinogen binding, form a subpopulation of phosphatidylserine-exposing platelets, and function in platelet-dependent star-like fibrin fiber formation via transglutaminase factor XIII and integrin αIIbβ3. PMID:26721892

Seven novel mutations in the factor XIII A-subunit gene causing hereditary factor XIII deficiency in 10 unrelated families.

PubMed

Vysokovsky, A; Saxena, R; Landau, M; Zivelin, A; Eskaraev, R; Rosenberg, N; Seligsohn, U; Inbal, A

2004-10-01

Hereditary factor (F)XIII deficiency is a rare bleeding disorder mostly due to mutations in FXIII A subunit. We studied the molecular basis of FXIII deficiency in patients from 10 unrelated families originating from Israel, India and Tunisia. Exons 2-15 of genomic DNA consisting of coding regions and intron/exon boundaries were amplified and sequenced. Structural analysis of the mutations was undertaken by computer modeling. Seven novel mutations were identified in the FXIIIA gene. The propositus from the Ethiopian-Jewish family was found to be a compound heterozygote for two novel mutations: a 10-bp deletion in exon 12 at nucleotides 1652-1661 (followed by 22 altered amino acids and termination codon) and Ala318Val mutation. The propositus of the Tunisian family was homozygous for C insertion after nucleotide 863 within a stretch of six cytosines of exon 7. This insertion results in generation of eight altered amino acids followed by a termination codon downstream. The propositus from Indian-Jewish origin was found to be homozygous for G to T substitution at IVS 11 [+1] resulting in skipping of exons 10 and 11. In addition to the Ala318Val mutation, three of the novel mutations identified are missense mutations: Arg260Leu, Thr398Asn and Gly210Arg each occurring in a homozygous state in an Israeli-Arab and two Indian families, respectively. Structure-function correlation analysis by computer modeling of the new missense mutations predicted that Gly210Arg will cause protein misfolding, Ala318Val and Thr398Asn will interfere with the catalytic process or protein stability, and Arg260Leu will impair dimerization.

Potential impact of HITECH security regulations on medical imaging.

PubMed

Prior, Fred; Ingeholm, Mary Lou; Levine, Betty A; Tarbox, Lawrence

2009-01-01

Title XIII of Division A and Title IV of Division B of the American Recovery and Reinvestment Act (ARRA) of 2009 [1] include a provision commonly referred to as the "Health Information Technology for Economic and Clinical Health Act" or "HITECH Act" that is intended to promote the electronic exchange of health information to improve the quality of health care. Subtitle D of the HITECH Act includes key amendments to strengthen the privacy and security regulations issued under the Health Insurance Portability and Accountability Act (HIPAA). The HITECH act also states that "the National Coordinator" must consult with the National Institute of Standards and Technology (NIST) in determining what standards are to be applied and enforced for compliance with HIPAA. This has led to speculation that NIST will recommend that the government impose the Federal Information Security Management Act (FISMA) [2], which was created by NIST for application within the federal government, as requirements to the public Electronic Health Records (EHR) community in the USA. In this paper we will describe potential impacts of FISMA on medical image sharing strategies such as teleradiology and outline how a strict application of FISMA or FISMA-based regulations could have significant negative impacts on information sharing between care providers.

Synergies between human space exploration and science in the asteroid redirect mission and the potential Italian participation in the asteroid redirect robotic mission phase⋆

NASA Astrophysics Data System (ADS)

Tantardini, Marco; Flamini, Enrico

2017-07-01

In 2010, the study proposal called Asteroid Retrieval Mission (ARM) was selected by the Keck Institute for Space Studies (KISS) at the California Institute of Technology (Caltech). ARM had, as its main goal, the ambition to give a feasible, and realistic from a budget standpoint, destination to NASA Human Space Exploration (HSE) after the International Space Station (ISS), fulfilling President Obama's goal to have astronaut reach and interact with an asteroid (NEO) by 2025. ARM was formulated exploiting synergies between HSE and science, and with benefits also for technology development and in-space validation. In 2013, ARM, renamed Asteroid Redirect Mission, became a NASA program with the support of the White House. The Italian Space Agency (ASI) expressed interest to participate in the robotic phase of ARM, called Asteroid Redirect Robotic Mission (ARRM). This presentation, given at the XIII National (Italian) Congress of Planetary Sciences, had the goal to introduce ARM to the Italian scientific community to gather proposals for the possible Italian participation in NASA ARRM, such as ASI payloads that could be possibly hosted on NASA ARRM.

46 CFR 199.180 - Training and drills.

Code of Federal Regulations, 2014 CFR

2014-10-01

... survival craft engine and accessories; (xiii) The recovery of survival craft and rescue boats, including... and operating the lifeboat engine; and (vii) Operating davits used for launching the liferafts. (2) Abandon-ship drills should also include conducting a mock search and rescue of passengers or special...

46 CFR 199.180 - Training and drills.

Code of Federal Regulations, 2012 CFR

2012-10-01

... survival craft engine and accessories; (xiii) The recovery of survival craft and rescue boats, including... and operating the lifeboat engine; and (vii) Operating davits used for launching the liferafts. (2) Abandon-ship drills should also include conducting a mock search and rescue of passengers or special...

46 CFR 199.180 - Training and drills.

Code of Federal Regulations, 2013 CFR

2013-10-01

... survival craft engine and accessories; (xiii) The recovery of survival craft and rescue boats, including... and operating the lifeboat engine; and (vii) Operating davits used for launching the liferafts. (2) Abandon-ship drills should also include conducting a mock search and rescue of passengers or special...

78 FR 16302 - Sunshine Act Meeting; Regular Board of Directors Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-14

..., Washington, DC 20005. STATUS: Open. CONTACT PERSON FOR MORE INFORMATION: Erica Hall, Assistant Corporate... Discussion IV. Financial Report V. DC Office Move VI. NCST Board VII. Homeownership Challenges..., NFMC & EHLP Reports XII. Executive Session XIII. Adjournment Erica Hall, Assistant Corporate Secretary...

The Business Case for Systems Engineering Study: Detailed Response Data

DTIC Science & Technology

2012-11-01

of Carnegie Mellon University. DM -0000794 CMU/SEI-2012-SR-011 | i Table of Contents Acknowledgments ix Executive Summary xi Abstract xiii...providing an SRD25 upfront with crisp requirements. Customer/acquirer consistently talks about SE but never practices SE. Customer practices SE

24 CFR 576.400 - Area-wide systems coordination requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

...): (8) Head Start (45 CFR chapter XIII, subchapter B); (9) Mental Health and Substance Abuse Block..., if any, on the homelessness prevention or rapid re-housing assistance that each program participant... HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES EMERGENCY SOLUTIONS GRANTS PROGRAM Program Requirements...

24 CFR 576.400 - Area-wide systems coordination requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

...): (8) Head Start (45 CFR chapter XIII, subchapter B); (9) Mental Health and Substance Abuse Block..., if any, on the homelessness prevention or rapid re-housing assistance that each program participant... HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES EMERGENCY SOLUTIONS GRANTS PROGRAM Program Requirements...

24 CFR 576.400 - Area-wide systems coordination requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

...): (8) Head Start (45 CFR chapter XIII, subchapter B); (9) Mental Health and Substance Abuse Block..., if any, on the homelessness prevention or rapid re-housing assistance that each program participant... HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES EMERGENCY SOLUTIONS GRANTS PROGRAM Program Requirements...

Highway Safety Information System guidebook for the Maine state data files. Volume 1 : SAS file formats

DOT National Transportation Integrated Search

2012-05-05

As part of the Federal Highway Administration (FHWA) Traffic Analysis Toolbox (Volume XIII), this guide was designed to help corridor stakeholders implement the ICM AMS methodology successfully and effectively. It provides a step-by-step approach to ...

40 CFR 60.53c - Operator training and qualification requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... and types of emissions; (ii) Basic combustion principles, including products of combustion; (iii) Operation of the type of incinerator to be used by the operator, including proper startup, waste charging... procedures; (xii) Pre-startup inspections; and (xiii) Recordkeeping requirements. (2) An examination designed...

40 CFR 60.53c - Operator training and qualification requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... and types of emissions; (ii) Basic combustion principles, including products of combustion; (iii) Operation of the type of incinerator to be used by the operator, including proper startup, waste charging... procedures; (xii) Pre-startup inspections; and (xiii) Recordkeeping requirements. (2) An examination designed...

46 CFR 199.180 - Training and drills.

Code of Federal Regulations, 2010 CFR

2010-10-01

... survival craft engine and accessories; (xiii) The recovery of survival craft and rescue boats, including... and operating the lifeboat engine; and (vii) Operating davits used for launching the liferafts. (2) Abandon-ship drills should also include conducting a mock search and rescue of passengers or special...

46 CFR 199.180 - Training and drills.

Code of Federal Regulations, 2011 CFR

2011-10-01

... survival craft engine and accessories; (xiii) The recovery of survival craft and rescue boats, including... and operating the lifeboat engine; and (vii) Operating davits used for launching the liferafts. (2) Abandon-ship drills should also include conducting a mock search and rescue of passengers or special...

Sylphellapuccoon gen. n., sp. n. and two additional new species of aquatic oligochaetes (Lumbriculidae, Clitellata) from poorly-known lotic habitats in North Carolina (USA).

PubMed

Rodriguez, Pilar; Fend, Steven V; Lenat, David R

2014-01-01

Three new species of Lumbriculidae were collected from floodplain seeps and small streams in southeastern North America. Some of these habitats are naturally acidic. Sylphellapuccoon gen. n., sp. n. has prosoporous male ducts in X-XI, and spermathecae in XII-XIII. Muscular, spherical atrial ampullae and acuminate penial sheaths distinguish this monotypic new genus from other lumbriculid genera having similar arrangements of reproductive organs. Cookidriluspocosinus sp. n. resembles its two subterranean, Palearctic congeners in the arrangement of reproductive organs, but is easily distinguished by the position of the spermathecal pores in front of the chaetae in X-XIII. Stylodriluscoreyi sp. n. differs from congeners having simple-pointed chaetae and elongate atria primarily by the structure of the male duct and the large clusters of prostate cells. Streams and wetlands of Southeastern USA have a remarkably high diversity of endemic lumbriculids, and these poorly-known invertebrates should be considered in conservation efforts.

Tabulation of comet observations.

NASA Astrophysics Data System (ADS)

1985-04-01

Concerning comets: 1961 VIII Seki, 1962 III Seki-Lines, 1963 I Ikeya, 1963 III Alcock, 1964 VIII Ikeya, 1965 VIII Ikeya-Seki, 1966 V Kilston, 1967 II Rudnicki, 1968 I Ikeya-Seki, 1968 VI Honda, 1969 IX Tago-Sato-Kosaka, 1970 II Bennett, 1971 V Toba, 1973 XII Kohoutek, 1974 II P/Schwassmann-Wachmann 1, 1974 III Bradfield, 1975 IX Kobayashi-Berger-Milon, 1975 X Suzuki-Saigusa-Mori, 1975 XII Mori-Sato-Fujikawa, 1976 VI West, 1976 XI P/d'Arrest, 1979 X Bradfield, 1980 XI P/Encke, 1980 XIII P/Tuttle, 1980 XV Bradfield, 1981 II Panther, 1982i P/Halley, 1983 XIII P/Kopff, 1983n P/Crommelin, 1983v P/Hartley-IRAS, 1983w P/Clark, 1984c P/Neujmin, 1984f Shoemaker, 1984g P/Wolf-Harrington, 1984h P/Faye, 1984i Austin, 1984j P/Takamizawa, 1984k P/Arend-Rigaux, 1984m P/Schaumasse, 1984p Tsuchinshan 1, 1984q P/Shoemaker 1, 1984s Shoemaker, 1984t Levy-Rudenko.

[A case of pancreatic and duodenal fistula after total gastrectomy successfully treated with coagulation factor XIII].

PubMed

Nishino, Hitoe; Kojima, Kazuhiro; Oshima, Hirokazu; Nakagawa, Koji; Fumura, Masao; Kikuchi, Norio

2013-11-01

Pancreatic fistula( PF) is a challenging postoperative complication. We report a case of PF following gastrectomy successfully treated using intravenous coagulation factor XIII( FXIII).A 78-year-old man with early gastric cancer underwent total gastrectomy with Roux-en-Y reconstruction. PF developed postoperatively, following which, leakage from the duodenal stump was observed. Percutaneous drainage and re-operative surgery were performed. A somatostatin analogue, antibiotic drugs, and gabexate mesilate were administrated along with nutritional support. The pancreatic and duodenal fistula had been producing duodenal juice for over 30 days since the re-operative surgery. As suspected, reduced FXIII activity was confirmed in the patient. After administering FXIII for 5 days, the amount of duodenal juice from the fistula markedly reduced, and the fistula closed immediately afterwards. The results of our study suggest that administration of FXIII could be a reasonable and effective treatment for patients with pancreatic or/and enterocutaneous fistula who are resistant to standard treatments.

Sylphella puccoon gen. n., sp. n. and two additional new species of aquatic oligochaetes (Lumbriculidae, Clitellata) from poorly-known lotic habitats in North Carolina (USA)

USGS Publications Warehouse

Rodriguez, Pilar; Fend, Steven V.; Lenat, David R.

2014-01-01

Three new species of Lumbriculidae were collected from floodplain seeps and small streams in southeastern North America. Some of these habitats are naturally acidic. Sylphella puccoon gen. n., sp. n. has prosoporous male ducts in X-XI, and spermathecae in XII-XIII. Muscular, spherical atrial ampullae and acuminate penial sheaths distinguish this monotypic new genus from other lumbriculid genera having similar arrangements of reproductive organs. Cookidrilus pocosinus sp. n. resembles its two subterranean, Palearctic congeners in the arrangement of reproductive organs, but is easily distinguished by the position of the spermathecal pores in front of the chaetae in X-XIII. Stylodrilus coreyi sp. n. differs from congeners having simple-pointed chaetae and elongate atria primarily by the structure of the male duct and the large clusters of prostate cells. Streams and wetlands of Southeastern USA have a remarkably high diversity of endemic lumbriculids, and these poorly-known invertebrates should be considered in conservation efforts.

Plasma-Assisted Synthesis and Surface Modification of Electrode Materials for Renewable Energy.

PubMed

Dou, Shuo; Tao, Li; Wang, Ruilun; El Hankari, Samir; Chen, Ru; Wang, Shuangyin

2018-05-01

Renewable energy technology has been considered as a "MUST" option to lower the use of fossil fuels for industry and daily life. Designing critical and sophisticated materials is of great importance in order to realize high-performance energy technology. Typically, efficient synthesis and soft surface modification of nanomaterials are important for energy technology. Therefore, there are increasing demands on the rational design of efficient electrocatalysts or electrode materials, which are the key for scalable and practical electrochemical energy devices. Nevertheless, the development of versatile and cheap strategies is one of the main challenges to achieve the aforementioned goals. Accordingly, plasma technology has recently appeared as an extremely promising alternative for the synthesis and surface modification of nanomaterials for electrochemical devices. Here, the recent progress on the development of nonthermal plasma technology is highlighted for the synthesis and surface modification of advanced electrode materials for renewable energy technology including electrocatalysts for fuel cells, water splitting, metal-air batteries, and electrode materials for batteries and supercapacitors, etc. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Friction Stir Processing of Particle Reinforced Composite Materials

PubMed Central

Gan, Yong X.; Solomon, Daniel; Reinbolt, Michael

2010-01-01

The objective of this article is to provide a review of friction stir processing (FSP) technology and its application for microstructure modification of particle reinforced composite materials. The main focus of FSP was on aluminum based alloys and composites. Recently, many researchers have investigated this technology for treating other alloys and materials including stainless steels, magnesium, titanium, and copper. It is shown that FSP technology is very effective in microstructure modification of reinforced metal matrix composite materials. FSP has also been used in the processing and structure modification of polymeric composite materials. Compared with other manufacturing processes, friction stir processing has the advantage of reducing distortion and defects in materials. The layout of this paper is as follows. The friction stir processing technology will be presented first. Then, the application of this technology in manufacturing and structure modification of particle reinforced composite materials will be introduced. Future application of friction stir processing in energy field, for example, for vanadium alloy and composites will be discussed. Finally, the challenges for improving friction stir processing technology will be mentioned.

Effect of surface modification on hydration kinetics of carbamazepine anhydrate using isothermal microcalorimetry.

PubMed

Otsuka, Makoto; Ishii, Mika; Matsuda, Yoshihisa

2003-01-01

The purpose of this research was to improve the stability of carbamazepine (CBZ) bulk powder under high humidity by surface modification. The surface-modified anhydrates of CBZ were obtained in a specially designed surface modification apparatus at 60 degrees C via the adsorption of n-butanol, and powder x-ray diffraction, Fourier-Transformed Infrared spectra, and differential scanning calorimetry were used to determine the crystalline characteristics of the samples. The hydration process of intact and surface-modified CBZ anhydrate at 97% relative humidity (RH) and 40 +/-C 1 degrees C was automatically monitored by using isothermal microcalorimetry (IMC). The dissolution test for surface-modified samples (20 mg) was performed in 900 mL of distilled water at 37 +/-C 0.5 degrees C with stirring by a paddle at 100 rpm as in the Japanese Pharmacopoeia XIII. The heat flow profiles of hydration of intact and surface-modified CBZ anhydrates at 97% RH by using IMC profiles showed a maximum peak at around 10 hours and 45 hours after 0 and 10 hours of induction, respectively. The result indicated that hydration of CBZ anhydrate was completely inhibited at the initial stage by surface modification of n-butanol and thereafter transformed into dihydrate. The hydration of surface-modified samples followed a 2-dimensional phase boundary process with an induction period (IP). The IP of intact and surface-modified samples decreased with increase of the reaction temperature, and the hydration rate constant (k) increased with increase of the temperature. The crystal growth rate constants of nuclei of the intact sample were significantly larger than the surface-modified sample's at each temperature. The activation energy (E) of nuclei formation and crystal growth process for hydration of surface-modified CBZ anhydrate were evaluated to be 20.1 and 32.5 kJ/mol, respectively, from Arrhenius plots, but the Es of intact anhydrate were 56.3 and 26.8 kJ/mol, respectively. The dissolution profiles showed that the surface-modified sample dissolved faster than the intact sample at the initial stage. The dissolution kinetics were analyzed based on the Hixon-Crowell equation, and the dissolution rate constants for intact and surface-modified anhydrates were found to be 0.0102 +/-C 0.008 mg(1/3) x min(-1) and 0.1442 +/-C 0.0482 mg(1/3) x min(-1). The surface-modified anhydrate powders were more stable than the nonmodified samples under high humidity and showed resistance against moisture. However, surface modification induced rapid dissolution in water compared to the control.

Ferrite Loaded Coils for Improved Wireless Power Transfer Efficiency

DTIC Science & Technology

2015-09-01

visible in yellow, from [4]. ..........................................................................................4  Figure 4.  The Odyssey AUV ...47  Figure 35.  System mockup of AUV in docking/charging station...42  xii THIS PAGE INTENTIONALLY LEFT BLANK xiii LIST OF ACRONYMS AND ABBREVIATIONS AUV Autonomous Underwater Vehicle CST

38 CFR 26.6 - Environmental documents.

Code of Federal Regulations, 2011 CFR

2011-07-01

... significant impact on, official local or regional zoning or comprehensive land use plans; and, (xiii...) Environmental Impact Statements. The head of each VA element shall include a detailed written statement “in... Regulations, 40 CFR part 1502. An environmental impact statement shall be prepared in accordance with the...

42 CFR 417.166 - Waiver of assurances.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) MEDICARE PROGRAM HEALTH MAINTENANCE ORGANIZATIONS, COMPETITIVE MEDICAL PLANS, AND HEALTH CARE... law; or (2) The HMO shows good cause, consistent with the purposes of title XIII of the PHS Act. (b... the reorganization can only be approved with the waiver of the assurances. (ii) State laws governing...

12 CFR 27.3 - Recordkeeping requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... employed by the current employer of the applicant(s). For self-employed persons, the number of continuous years self-employed. (xiii) Gross total monthly income of each applicant, comprising the sum of normal... or disability income and income from part-time employment. For self-employed persons, include the...

25 CFR 36.40 - Standard XIII-Library/media program.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION MINIMUM ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN AND NATIONAL CRITERIA FOR DORMITORY SITUATIONS Instructional Support... inclusive of materials located in the classrooms shall be maintained. This category includes some of each of...

27 CFR 9.108 - Ozark Mountain.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Creek; (xii) Then northeastward along Rock Creek to Petit Jean Creek; (xiii) Then generally northeastward and eastward along Petit Jean Creek until it becomes the Petit Jean River (on the Russellville map); (xiv) Then generally eastward along the Petit Jean River, flowing through Blue Mountain Lake, until the...

27 CFR 9.108 - Ozark Mountain.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Creek; (xii) Then northeastward along Rock Creek to Petit Jean Creek; (xiii) Then generally northeastward and eastward along Petit Jean Creek until it becomes the Petit Jean River (on the Russellville map); (xiv) Then generally eastward along the Petit Jean River, flowing through Blue Mountain Lake, until the...

27 CFR 9.108 - Ozark Mountain.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Creek; (xii) Then northeastward along Rock Creek to Petit Jean Creek; (xiii) Then generally northeastward and eastward along Petit Jean Creek until it becomes the Petit Jean River (on the Russellville map); (xiv) Then generally eastward along the Petit Jean River, flowing through Blue Mountain Lake, until the...

27 CFR 9.108 - Ozark Mountain.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Creek; (xii) Then northeastward along Rock Creek to Petit Jean Creek; (xiii) Then generally northeastward and eastward along Petit Jean Creek until it becomes the Petit Jean River (on the Russellville map); (xiv) Then generally eastward along the Petit Jean River, flowing through Blue Mountain Lake, until the...

Incentive Pay for Remotely Piloted Aircraft Career Fields

DTIC Science & Technology

2012-01-01

Fields C.1. Mathematical Symbols for Non-Stochastic Values and Shock Terms...78 C.2. Mathematical Symbols for Taste and Compensation . . . . . . . . . . . 79 xiii Summary Background and...manning requirement, even with the current incentive pays and reenlistment bonuses. 2 The mathematical foundations, data, and estimation methods for the

40 CFR 62.14595 - What are the operator training and qualification requirements?

Code of Federal Regulations, 2010 CFR

2010-07-01

... charging, and shutdown procedures. (iv) Combustion controls and monitoring. (v) Operation of air pollution... the incinerator and air pollution control devices. (vii) Actions to correct malfunctions or conditions... requirements. (xiii) Methods to continuously monitor CISWI unit and air pollution control device operating...

40 CFR 62.14595 - What are the operator training and qualification requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

... charging, and shutdown procedures. (iv) Combustion controls and monitoring. (v) Operation of air pollution... the incinerator and air pollution control devices. (vii) Actions to correct malfunctions or conditions... requirements. (xiii) Methods to continuously monitor CISWI unit and air pollution control device operating...

75 FR 42000 - Requirements for Fingerprint-Based Criminal History Records Checks for Individuals Seeking...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-20

... Compatibility VIII. Plain Language IX. Voluntary Consensus Standards X. Finding of No Significant Environmental Impact: Availability XI. Paperwork Reduction Act Statement XII. Regulatory Analysis: Availability XIII... received seven comment letters from interested parties: Four from RTR licensees, one from the Nuclear...

76 FR 6199 - Enhanced Weapons, Firearms Background Checks, and Security Event Notifications

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... XI. Voluntary Consensus Standards XII. Finding of No Significant Environmental Impact XIII. Paperwork... potential advantages to NRC licensees and certificate holders to enhance security. The first advantage is... advantage is that security personnel of certain licensees or certificate holders will be permitted to...

40 CFR Appendix Xiii to Part 266 - Mercury Bearing Wastes That May Be Processed in Exempt Mercury Recovery Units

Code of Federal Regulations, 2011 CFR

2011-07-01

... are exempt mercury-bearing materials with less than 500 ppm of 40 CFR Part 261, appendix VIII organic... tank sludge 13. Mercury cell process solids 14. Recoverable levels of mercury contained in soil [59 FR...

40 CFR Appendix Xiii to Part 266 - Mercury Bearing Wastes That May Be Processed in Exempt Mercury Recovery Units

Code of Federal Regulations, 2012 CFR

2012-07-01

... are exempt mercury-bearing materials with less than 500 ppm of 40 CFR Part 261, appendix VIII organic... tank sludge 13. Mercury cell process solids 14. Recoverable levels of mercury contained in soil [59 FR...

40 CFR Appendix Xiii to Part 266 - Mercury Bearing Wastes That May Be Processed in Exempt Mercury Recovery Units

Code of Federal Regulations, 2014 CFR

2014-07-01

... are exempt mercury-bearing materials with less than 500 ppm of 40 CFR Part 261, appendix VIII organic... tank sludge 13. Mercury cell process solids 14. Recoverable levels of mercury contained in soil [59 FR...

40 CFR Appendix Xiii to Part 266 - Mercury Bearing Wastes That May Be Processed in Exempt Mercury Recovery Units

Code of Federal Regulations, 2010 CFR

2010-07-01

... are exempt mercury-bearing materials with less than 500 ppm of 40 CFR Part 261, appendix VIII organic... tank sludge 13. Mercury cell process solids 14. Recoverable levels of mercury contained in soil [59 FR...

40 CFR Appendix Xiii to Part 266 - Mercury Bearing Wastes That May Be Processed in Exempt Mercury Recovery Units

Code of Federal Regulations, 2013 CFR

2013-07-01

... are exempt mercury-bearing materials with less than 500 ppm of 40 CFR Part 261, appendix VIII organic... tank sludge 13. Mercury cell process solids 14. Recoverable levels of mercury contained in soil [59 FR...

7. Photocopied December 1977, form F.B. Tower, Illustrations of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photocopied December 1977, form F.B. Tower, Illustrations of the Croton Aqueduct, New York: Wiley and Putnam, 1843. CROTON AQUEDUCT AT SING SING, PLATE XIII, PAGE 101. - Old Croton Aqueduct, Sing Sing Kill Bridge, Spanning Aqueduct Street & Broadway, Ossining, Westchester County, NY

Tabulation of comet observations.

NASA Astrophysics Data System (ADS)

1993-10-01

Concerning comets: 1955 III Mrkos, 1955 IV Bakharev-Macfarlane-Krienke, 1955 V Honda, 1956 III Mrkos, 1956 IV P/Olbers, 1957 III Arend-Roland, 1957 V Mrkos, 1958 III Burnham, 1959 VIII P/Giacobini-Zinner, 1960 II Burnham, 1973 XII Kohoutek, 1974 III Bradfield, 1975 IX Kobayashi-Berger-Milon, 1975 X Suzuki-Saigusa-Mori, 1975 XI Bradfield, 1975 XII Mori-Sato-Fujikawa, 1976 IV Bradfield, 1976 VI West, 1979 VII Bradfield, 1980 X P/Stephan-Oerma, 1980 XII Meier, 1980 XIII P/Tuttle, 1981 II Panther, 1981 IV P/Borrelly, 1981 XIX P/Swift-Gehrels, 1982 I Bowell, 1982 IV P/Grigg-Skjellerup, 1982 VI Austin, 1982 VII P/d'Arrest, 1982 VIII P/Churyumov-Gerasimenko, 1983 V Sugano-Saigusa-Fujikawa, 1983 VII IRAS-Araki-Alcock, 1983 X P/Tempel 2, 1983 XI P/Tempel 1, 1983 XIII P/Kopff, 1983 XIV P/IRAS, 1983 XV Shoemaker, 1984 III P/Hartley-IRAS, 1984 IV P/Crommelin, 1984 XI P/Faye, 1984 XIII Austin, 1984 XIV P/Wild 2, 1984 XVI P/Shoemaker 1, 1984 XXIII Levy-Rudenko, 1985 I P/Tsuchinshan 1, 1985 XIII P/Giacobini-Zinner, 1985 XV P/Giclas, 1985 XVI P/Ciffréo, 1985 XVII Hartley-Good, 1985 XVIII P/Shoemaker 3, 1985 XIX Thiele, 1986 I P/Boethin, 1986 III P/Halley, 1986 VIII P/Machholz, 1986 XVII Levy, 1986 XVIII Terasako, 1987 II Sorrells, 1987 VII Wilson, 1987 XIX P/Schwassmann-Wachmann 2, 1987 XXI Levy, 1987 XXIII Rudenko, 1987 XXIV P/Brooks 2, 1987 XXVII P/Kohoutek, 1987 XXIX Bradfield, 1988 IV Furuyama, 1988 XIV P/Tempel 2, 1989 III Shoemaker, 1989 XV P/Schwassmann-Wachmann 1, 1989 XIX Okazaki-Levy-Rudenko, 1990 V Austin, 1990 XVII Tsuchiya-Kiuchi, 1990 XX Levy, 1990 XXI P/Encke, 1990 XXVI Arai, 1991 I P/Metcalf-Brewington, 1991 XV P/Hartley 2, 1991 XVII P/Arend-Rigaux, 1991a1 Shoemaker-Levy, 1991g1 Zanotta-Brewington, 1992c P/Howell, 1992d Tanaka-Machholz, 1992e P/Singer Brewster, 1992f P/Shoemaker-Levy 8, 1992h Spacewatch, 1992j P/Ashbrook-Jackson, 1992t P/Swift-Tuttle, 1992u P/Väisälä 1, 1992w P/Slaughter-Burnham, 1992x P/Schaumasse, 1992y Shoemaker, 1993a Mueller, 1993d Mueller, 1993e P/Shoemaker-Levy 9, 1993f P/Forbes, 1993i P/Holmes, 1993j P/Neujmin 3, 1993k P/Shajn-Schaldach, 1993l P/Helin-Lawrence, 1993m P/Hartley 3, 1993n P/Whipple, 1993ο P/West-Kohoutek-Ikemura, 1993p Mueller, P/Smirnova-Chernykh.

Recent Advances in Attention Bias Modification for Substance Addictions

PubMed Central

Zhang, Melvyn Weibin; Ying, Jiang Bo; Song, Guo; Fung, Daniel S. S.; Smith, Helen E.

2018-01-01

Research on attentional bias modification has increased since 2014. A recent meta-analysis demonstrates evidence for bias modification for substance disorders, including alcohol and tobacco use disorders. Several pharmacological trials have shown that pharmacological agents can attenuate and modify such attentional bias. The pharmacological trials that have appeared to date have produced mixed results, which has clinical implications. Developments in Internet and mobile technologies have transformed how attention bias modification is currently being achieved. There remains great potential for further research that examines the efficacy of technology-aided attention bias interventions. PMID:29617325

Understanding RNA modifications: the promises and technological bottlenecks of the ‘epitranscriptome’

PubMed Central

Kapoor, Utkarsh

2017-01-01

The discovery of mechanisms that alter genetic information via RNA editing or introducing covalent RNA modifications points towards a complexity in gene expression that challenges long-standing concepts. Understanding the biology of RNA modifications represents one of the next frontiers in molecular biology. To this date, over 130 different RNA modifications have been identified, and improved mass spectrometry approaches are still adding to this list. However, only recently has it been possible to map selected RNA modifications at single-nucleotide resolution, which has created a number of exciting hypotheses about the biological function of RNA modifications, culminating in the proposition of the ‘epitranscriptome’. Here, we review some of the technological advances in this rapidly developing field, identify the conceptual challenges and discuss approaches that are needed to rigorously test the biological function of specific RNA modifications. PMID:28566301

7 CFR 1485.16 - Contribution rules.

Code of Federal Regulations, 2014 CFR

2014-01-01

... business cards that target a foreign audience; (viii) The cost of seasonal greeting cards; (ix) Fees for... conducted overseas; (xii) Credit card fees; (xiii) The cost of any independent evaluation or audit that is...) Membership fees in clubs and social organizations; and (xi) Any expenditure for an activity prior to CCC's...

7 CFR 1485.13 - Application process and strategic plan.

Code of Federal Regulations, 2012 CFR

2012-01-01

... business cards; (viii) The cost of seasonal greeting cards; (ix) Fees for office parking; (x) The cost of subscriptions to publications; (xi) The cost of activities conducted overseas; (xii) Credit card fees; (xiii... fees or similar sales expenditures; (x) Membership fees in clubs and social organizations; and (xi) Any...

7 CFR 1485.16 - Contribution rules.

Code of Federal Regulations, 2013 CFR

2013-01-01

... business cards that target a foreign audience; (viii) The cost of seasonal greeting cards; (ix) Fees for... conducted overseas; (xii) Credit card fees; (xiii) The cost of any independent evaluation or audit that is...) Membership fees in clubs and social organizations; and (xi) Any expenditure for an activity prior to CCC's...

[Bio-nanoscience and bio-nanotechnology: social and ethical aspects].

PubMed

Martín-Lomas, Manuel

2006-01-01

This article is an abstract of a conference with the same title presented at the XIII Jornadas sobre Derecho y Genoma Humano and is basically centred in a report for the Royal Society and the Royal Academy of Engineering entitled Nanoscience and Nanotechnology made publicly available July 2004.

46 CFR 56.01-10 - Plan approval.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ballast piping. (vii) Tank cleaning piping. (viii) Condenser circulating water piping. (ix) Vent, sound....) (xii) Cargo piping. (xiii) Hot water heating systems if the temperature is greater than 121 °C(250 °F... substantiate their compliance with the regulations of this subchapter; (3) A thermal stress analysis is not...

Higher Education: Handbook of Theory and Research. Volume XIII.

ERIC Educational Resources Information Center

Smart, John C., Ed.

The 10 papers in this handbook consider higher education theory and research. Following an opening essay, "Recollections and Reflections," by C. Robert Pace, which offers reflections on higher education as a field, on its evolution, and it future research needs, papers include: "Reflections on the Study of Effective College Teaching…

Single-cycle Optical Pulses and Isolated Attosecond Pulse Generation

DTIC Science & Technology

2012-02-29

picosecond green light from a frequency-doubled hybrid cryogenic Yb:YAG laser system,” 36 UFO /HFSW 2009 (Arcachon, France, Aug. 31-Sept. 4, 2009...High Fields Short Wavelength,” ( UFO VII – HFSW XIII), Arcachon, France, August 31 – September 4, 2009 (invited). 25) Kyung-Han Hong, Juliet Gopinath

45 CFR 307.11 - Functional requirements for computerized support enforcement systems in operation by October 1...

Code of Federal Regulations, 2011 CFR

2011-10-01

... violence or child abuse); (xi) Indication of an order; (xii) Locate request type (optional); (xiii) Locate... to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPUTERIZED SUPPORT...

45 CFR 307.11 - Functional requirements for computerized support enforcement systems in operation by October 1...

Code of Federal Regulations, 2013 CFR

2013-10-01

... violence or child abuse); (xi) Indication of an order; (xii) Locate request type (optional); (xiii) Locate... to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPUTERIZED SUPPORT...

45 CFR 307.11 - Functional requirements for computerized support enforcement systems in operation by October 1...

Code of Federal Regulations, 2012 CFR

2012-10-01

... violence or child abuse); (xi) Indication of an order; (xii) Locate request type (optional); (xiii) Locate... to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPUTERIZED SUPPORT...

32 CFR 505.7 - Disclosure of personal information to other agencies and third parties.

Code of Federal Regulations, 2010 CFR

2010-07-01

... for federal employment); (xii) Social Security Number (SSN); and (xiii) The information that would... released if their positions or duties require frequent interaction with the public. (3) Disclosure of.... (g) Social rosters. (1) Before including personal information such as a spouse's name, home addresses...

76 FR 17870 - Medicare and Medicaid Programs; Quarterly Listing of Program Issuances-October Through December 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-31

... Registry (NOPR) Sites. Addendum XIII: Medicare-approved Ventricular Assist Device (Destination Therapy... Therapy) Facilities (October Through December 2010) On October 1, 2003, we issued our decision memorandum on ventricular assist devices (VADs) for the clinical indication of destination therapy. We...

40 CFR 63.1207 - What are the performance testing requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

... incinerators, cement kilns, and lightweight aggregate kilns, you must commence the initial comprehensive... performance test operating conditions, as provided by paragraph (g)(1)(iii) of this section; (xiii) For cement... preheater or preheater/precalciner cement kilns with dual stacks, if you elect to use the emissions...

78 FR 70352 - Notice of Government in the Sunshine Regular Board of Directors Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-25

... NEIGHBORHOOD REINVESTMENT CORPORATION Notice of Government in the Sunshine Regular Board of.... Approval of Minutes III. Management Internal Operations Review IV. Non-Network Grant Policy V. MHA... Board XIII. Adjournment Jeffrey T. Bryson, General Counsel/Secretary. [FR Doc. 2013-28325 Filed 11-21-13...

38 CFR 3.815 - Monetary allowance under 38 U.S.C. chapter 18 for an individual with disability from covered...

Code of Federal Regulations, 2012 CFR

2012-07-01

..., the following: (i) Down syndrome and other Trisomies; (ii) Fragile X syndrome; (iii) Klinefelter's... atresia; (vi) Hallerman-Streiff syndrome; (vii) Hip dysplasia; (viii) Hirschprung's disease (congenital...) Neural tube defects (including spina bifida, encephalocele, and anencephaly); (xiii) Poland syndrome...

38 CFR 3.815 - Monetary allowance under 38 U.S.C. chapter 18 for an individual with disability from covered...

Code of Federal Regulations, 2013 CFR

2013-07-01

..., the following: (i) Down syndrome and other Trisomies; (ii) Fragile X syndrome; (iii) Klinefelter's... atresia; (vi) Hallerman-Streiff syndrome; (vii) Hip dysplasia; (viii) Hirschprung's disease (congenital...) Neural tube defects (including spina bifida, encephalocele, and anencephaly); (xiii) Poland syndrome...

38 CFR 3.815 - Monetary allowance under 38 U.S.C. chapter 18 for an individual with disability from covered...

Code of Federal Regulations, 2014 CFR

2014-07-01

..., the following: (i) Down syndrome and other Trisomies; (ii) Fragile X syndrome; (iii) Klinefelter's... atresia; (vi) Hallerman-Streiff syndrome; (vii) Hip dysplasia; (viii) Hirschprung's disease (congenital...) Neural tube defects (including spina bifida, encephalocele, and anencephaly); (xiii) Poland syndrome...

7 CFR 25.1 - Applicability and scope.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Reconciliation Act of 1993, title XIII, subchapter C, part I (Round I), the Taxpayer Relief Act of 1997, title IX, subtitle F (Round II), the Agriculture, Rural Development, Food and Drug Administration, and Related Agencies Appropriations Act, 1999 (Public Law 105-277) (Round IIS), and the Community Renewal Tax Relief...

7 CFR 25.1 - Applicability and scope.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Reconciliation Act of 1993, title XIII, subchapter C, part I (Round I), the Taxpayer Relief Act of 1997, title IX, subtitle F (Round II), the Agriculture, Rural Development, Food and Drug Administration, and Related Agencies Appropriations Act, 1999 (Public Law 105-277) (Round IIS), and the Community Renewal Tax Relief...

7 CFR 25.1 - Applicability and scope.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Reconciliation Act of 1993, title XIII, subchapter C, part I (Round I), the Taxpayer Relief Act of 1997, title IX, subtitle F (Round II), the Agriculture, Rural Development, Food and Drug Administration, and Related Agencies Appropriations Act, 1999 (Public Law 105-277) (Round IIS), and the Community Renewal Tax Relief...

32 CFR 865.114 - Decisional document.

Code of Federal Regulations, 2010 CFR

2010-07-01

... punishment). (xii) Conviction by court-martial. (xiii) Prior military service and type of discharge received. (3) A list of the type of documents submitted by or on behalf of the applicant (including a written... documentary evidence), if any. (4) A statement whether the applicant testified, and a list of the type of...

15 CFR 30.3 - Electronic Export Information filer requirements, parties to export transactions, and...

Code of Federal Regulations, 2013 CFR

2013-01-01

.../units of measure. (ix) Value. (x) Export Control Classification Number (ECCN) or sufficient technical information to determine the ECCN. (xi) All licensing information necessary to file the EEI for commodities... export. (xi) Foreign port of unloading. (xii) Shipping weight. (xiii) ECCN. (xiv) License or license...

15 CFR 30.3 - Electronic Export Information filer requirements, parties to export transactions, and...

Code of Federal Regulations, 2010 CFR

2010-01-01

.../units of measure. (ix) Value. (x) Export Control Classification Number (ECCN) or sufficient technical information to determine the ECCN. (xi) All licensing information necessary to file the EEI for commodities... export. (xi) Foreign port of unloading. (xii) Shipping weight. (xiii) ECCN. (xiv) License or license...

15 CFR 30.3 - Electronic Export Information filer requirements, parties to export transactions, and...

Code of Federal Regulations, 2012 CFR

2012-01-01

.../units of measure. (ix) Value. (x) Export Control Classification Number (ECCN) or sufficient technical information to determine the ECCN. (xi) All licensing information necessary to file the EEI for commodities... export. (xi) Foreign port of unloading. (xii) Shipping weight. (xiii) ECCN. (xiv) License or license...

15 CFR 30.3 - Electronic Export Information filer requirements, parties to export transactions, and...

Code of Federal Regulations, 2014 CFR

2014-01-01

.../units of measure. (ix) Value. (x) Export Control Classification Number (ECCN) or sufficient technical information to determine the ECCN. (xi) All licensing information necessary to file the EEI for commodities... export. (xi) Foreign port of unloading. (xii) Shipping weight. (xiii) ECCN. (xiv) License or license...

15 CFR 30.3 - Electronic Export Information filer requirements, parties to export transactions, and...

Code of Federal Regulations, 2011 CFR

2011-01-01

.../units of measure. (ix) Value. (x) Export Control Classification Number (ECCN) or sufficient technical information to determine the ECCN. (xi) All licensing information necessary to file the EEI for commodities... export. (xi) Foreign port of unloading. (xii) Shipping weight. (xiii) ECCN. (xiv) License or license...

Photogrammetric camera calibration

USGS Publications Warehouse

Tayman, W.P.; Ziemann, H.

1984-01-01

Section 2 (Calibration) of the document "Recommended Procedures for Calibrating Photogrammetric Cameras and Related Optical Tests" from the International Archives of Photogrammetry, Vol. XIII, Part 4, is reviewed in the light of recent practical work, and suggestions for changes are made. These suggestions are intended as a basis for a further discussion. ?? 1984.

38 CFR 17.81 - Contracts for residential treatment services for veterans with alcohol or drug dependence or...

Code of Federal Regulations, 2014 CFR

2014-07-01

... contract. (6) Demonstrate an existing capability to furnish the following: (i) A supervised alcohol and... social service. (x) Individual counseling as appropriate. (xi) Opportunities for learning/development of...-free life style). (xiii) Opportunities for learning, testing, and internalizing knowledge of illness...

38 CFR 17.81 - Contracts for residential treatment services for veterans with alcohol or drug dependence or...

Code of Federal Regulations, 2013 CFR

2013-07-01

... contract. (6) Demonstrate an existing capability to furnish the following: (i) A supervised alcohol and... social service. (x) Individual counseling as appropriate. (xi) Opportunities for learning/development of...-free life style). (xiii) Opportunities for learning, testing, and internalizing knowledge of illness...

75 FR 55274 - Change of Address for Region 5 State and Local Agencies; Technical Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-10

... Health District, Air Pollution Control, 33 Mill Street, Painesville, OH 44077. (xiv) Mahoning and...; Director, Canton City Health Department, Air Pollution Control Division, 420 Market Avenue North, Canton.... (xiii) Geauga and Lake Counties; Lake County General Health District, Air Pollution Control, 33 Mill...

Emergence of new sub-genotypes of virulent Newcastle disease virus with panzootic features

USDA-ARS?s Scientific Manuscript database

Newcastle disease virus (NDV) strains with epizootic characteristics from three new sub-genotypes of genotypes VII and XIII are rapidly spreading through Asia and the Middle East causing outbreaks of Newcastle disease (ND) that are producing significant illness and mortality in vaccinated poultry, s...

Retrovirus-based vectors for transient and permanent cell modification.

PubMed

Schott, Juliane W; Hoffmann, Dirk; Schambach, Axel

2015-10-01

Retroviral vectors are commonly employed for long-term transgene expression via integrating vector technology. However, three alternative retrovirus-based platforms are currently available that allow transient cell modification. Gene expression can be mediated from either episomal DNA or RNA templates, or selected proteins can be directly transferred through retroviral nanoparticles. The different technologies are functionally graded with respect to safety, expression magnitude and expression duration. Improvement of the initial technologies, including modification of vector designs, targeted increase in expression strength and duration as well as improved safety characteristics, has allowed maturation of retroviral systems into efficient and promising tools that meet the technological demands of a wide variety of potential application areas. Copyright © 2015 Elsevier Ltd. All rights reserved.

Investigation of surface halide modification of nitrile butadiene rubber

NASA Astrophysics Data System (ADS)

Sukhareva, K. V.; Mikhailov, I. A.; Andriasyan, Yu O.; Mastalygina, E. E.; Popov, A. A.

2017-12-01

The investigation is devoted to the novel technology of surface halide modification of rubber samples based on nitrile butadiene rubber (NBR). 1,1,2-trifluoro-1,2,2-trichlorethane was used as halide modifier. The developed technology is characterized by production stages reduction to one by means of treating the rubber compound with a halide modifier. The surface halide modification of compounds based on nitrile butadiene rubber (NBR) was determined to result in increase of resistance to thermal oxidation and aggressive media. The conducted research revealed the influence of modification time on chemical resistance and physical-mechanical properties of rubbers under investigation.

Controlling the potential hazards of government-sponsored technology. [such as weather modification and the supersonic transports

NASA Technical Reports Server (NTRS)

Wollan, M. J.

1975-01-01

The ability was examined of governmental agencies to adequately assess technological programs or projects to which they are committed. The hazards of government-sponsored activities are discussed; these include weather modification, supersonic transport noise, and the value conflicts involved in the fluoridation controversy. These three case studies indicate that the Federal vested interests in the continuation of its technological programs limit its ability to provide adequate technology assessment.

Thermal evolution of the metastable r8 and bc8 polymorphs of silicon

DOE PAGES

Haberl, Bianca; Guthrie, Malcolm; Sinogeikin, Stanislav V.; ...

2015-01-28

The kinetics of two metastable polymorphs of silicon under thermal annealing was investigated. These phases with body-centered cubic bc8 and rhombohedral r8 structures can be formed upon pressure release from metallic silicon.We study these metastable polymorphs were formed by two different methods, via point loading and in a diamond anvil cell (DAC). Upon thermal annealing different transition pathways were detected. In the point loading case, the previously reported Si-XIII formed and was confirmed as a new phase with an as-yet-unidentified structure. In the DAC case, bc8-Si transformed to the hexagonal-diamond structure at elevated pressure, consistent with previous studies at ambientmore » pressure. In contrast, r8-Si transformed directly to diamond-cubic Si at a temperature of 255⁰C. In conclusion, these data were used to construct diagrams of the metastability regimes of the polymorphs formed in a DAC and may prove useful for potential technological applications of these metastable polymorphs.« less

Thermal evolution of the metastable r8 and bc8 polymorphs of silicon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haberl, Bianca; Guthrie, Malcolm; Sinogeikin, Stanislav V.

The kinetics of two metastable polymorphs of silicon under thermal annealing was investigated. These phases with body-centered cubic bc8 and rhombohedral r8 structures can be formed upon pressure release from metallic silicon.We study these metastable polymorphs were formed by two different methods, via point loading and in a diamond anvil cell (DAC). Upon thermal annealing different transition pathways were detected. In the point loading case, the previously reported Si-XIII formed and was confirmed as a new phase with an as-yet-unidentified structure. In the DAC case, bc8-Si transformed to the hexagonal-diamond structure at elevated pressure, consistent with previous studies at ambientmore » pressure. In contrast, r8-Si transformed directly to diamond-cubic Si at a temperature of 255⁰C. In conclusion, these data were used to construct diagrams of the metastability regimes of the polymorphs formed in a DAC and may prove useful for potential technological applications of these metastable polymorphs.« less

30 CFR 18.81 - Field modification of approved (permissible) equipment; application for approval of modification...

Code of Federal Regulations, 2014 CFR

2014-07-01

... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES... and Certification Center, 765 Technology Drive, Triadelphia, WV 26059. (b) Proposed modifications...

Crystal structure of laser-induced subsurface modifications in Si

NASA Astrophysics Data System (ADS)

Verburg, P. C.; Smillie, L. A.; Römer, G. R. B. E.; Haberl, B.; Bradby, J. E.; Williams, J. S.; Huis in't Veld, A. J.

2015-08-01

Laser-induced subsurface modification of dielectric materials is a well-known technology. Applications include the production of optical components and selective etching. In addition to dielectric materials, the subsurface modification technology can be applied to silicon, by employing near to mid-infrared radiation. An application of subsurface modifications in silicon is laser-induced subsurface separation, which is a method to separate wafers into individual dies. Other applications for which proofs of concept exist are the formation of waveguides and resistivity tuning. However, limited knowledge is available about the crystal structure of subsurface modifications in silicon. In this work, we investigate the geometry and crystal structure of laser-induced subsurface modifications in monocrystalline silicon wafers. In addition to the generation of lattice defects, we found that transformations to amorphous silicon and Si -iii/Si -xii occur as a result of the laser irradiation.

Surface and interface modification science and technology.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, J.-H.

1999-07-19

Surface modification of solids is of scientific and technological interest due to its significant benefits in a wide variety of applications. Various coatings applications such as corrosion protection and electrical insulators and conductors are required for proper engineering design based on geometrical relationships between interfaces and on thermodynamic/kinetic considerations for the development of surface modifications. This paper will explore three basic examples: the proton conductor BaCeO{sub 3}, high-temperature protective coatings, and epitaxial relationships between interfaces.

MODIFICATIONS TO REDUCE DRAG OUT AT A PRINTED CIRCUIT BOARD MANUFACTURER

EPA Science Inventory

This MnTAP/EPA Waste Reduction Innovative Technology Evaluation project at Micom, Inc., demonstrated the waste reducing capability of two simple rinsing modifications on an etchant and an electroless copper process. he simple, tow (or no) cost, low technology changes that were ma...

Waiving a requirement of clause 6(a) of rule XIII with respect to consideration of certain resolutions reported from the Committee on Rules.

THOMAS, 111th Congress

Rep. Cardoza, Dennis A. [D-CA-18

2010-06-30

House - 07/14/2010 Pursuant to the provisions of H. Res. 1509, H. Res. 1496 is laid on the table. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

11 CFR 300.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 6, 2002, the receipt of such funds prior to November 6, 2002 shall have no bearing on determining... if we can count on you for $10,000.” (xiii) “Your contribution to this campaign would mean a great... entire Democratic ticket in November.” (vi) A Federal officeholder says: “Our Senator has done a great...

11 CFR 300.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 6, 2002, the receipt of such funds prior to November 6, 2002 shall have no bearing on determining... if we can count on you for $10,000.” (xiii) “Your contribution to this campaign would mean a great... entire Democratic ticket in November.” (vi) A Federal officeholder says: “Our Senator has done a great...

11 CFR 300.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 6, 2002, the receipt of such funds prior to November 6, 2002 shall have no bearing on determining... if we can count on you for $10,000.” (xiii) “Your contribution to this campaign would mean a great... entire Democratic ticket in November.” (vi) A Federal officeholder says: “Our Senator has done a great...

11 CFR 300.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 6, 2002, the receipt of such funds prior to November 6, 2002 shall have no bearing on determining... if we can count on you for $10,000.” (xiii) “Your contribution to this campaign would mean a great... entire Democratic ticket in November.” (vi) A Federal officeholder says: “Our Senator has done a great...

Testing of New Bridge Rail and Transition Designs Vol. XIII Appendix L 32-in (813-mm) Thrie-Beam Transition

DOT National Transportation Integrated Search

1997-06-01

This report presents the results of a State Planning and Research (SP&R) pooled-fund study to develop safer bridge rail and transition designsThis pooled-fund study was sponsored by the Federal Highway Administration, 23 States, and the District of C...

38 CFR 36.4340 - Underwriting standards, processing procedures, lender responsibility, and lender certification.

Code of Federal Regulations, 2013 CFR

2013-07-01

... equity in refinancing loans; (vii) Little or no increase in shelter expense; (viii) Military benefits...; (xii) Tax credits of a continuing nature, such as tax credits for child care; and (xiii) Tax benefits... supplied in the Consumer Expenditure Survey (CES) published by the Department of Labor's Bureau of Labor...

38 CFR 36.4340 - Underwriting standards, processing procedures, lender responsibility, and lender certification.

Code of Federal Regulations, 2014 CFR

2014-07-01

... streamlined refinance loan would not increase the principal balance outstanding on the prior existing... refinancing loans; (vii) Little or no increase in shelter expense; (viii) Military benefits; (ix) Satisfactory... continuing nature, such as tax credits for child care; and (xiii) Tax benefits of home ownership. (6) The...

38 CFR 36.4340 - Underwriting standards, processing procedures, lender responsibility, and lender certification.

Code of Federal Regulations, 2011 CFR

2011-07-01

... equity in refinancing loans; (vii) Little or no increase in shelter expense; (viii) Military benefits...; (xii) Tax credits of a continuing nature, such as tax credits for child care; and (xiii) Tax benefits... supplied in the Consumer Expenditure Survey (CES) published by the Department of Labor's Bureau of Labor...

38 CFR 36.4340 - Underwriting standards, processing procedures, lender responsibility, and lender certification.

Code of Federal Regulations, 2012 CFR

2012-07-01

... equity in refinancing loans; (vii) Little or no increase in shelter expense; (viii) Military benefits...; (xii) Tax credits of a continuing nature, such as tax credits for child care; and (xiii) Tax benefits... supplied in the Consumer Expenditure Survey (CES) published by the Department of Labor's Bureau of Labor...

Distance Learning Plan for the Defense Finance and Accounting Service (DFAS): A Study for the DBMU

DTIC Science & Technology

1994-09-01

according to the standard (H.261) motion video compression algorithm.24 n Schaphorst, Richard, notes presented at TELECON XIII, San Jose , California, 10...include automatic microphone mixing systems with one microphone for every two student seats, a large screen interactive computer display and the Socrates

Bangladesh v. India: A Positive Step Forward in Public Order of the Seas

DTIC Science & Technology

2017-09-05

between India and Bangladesh, “regarding the delimitation of the maritime boundary between them in the territorial sea, the exclusive economic zone...Diplomatic Relations ................................................................................................... 31 Political and Economic ...xiii Glossary CLCS Commission on the Limits of the Continental Shelf EEZ Exclusive Economic Zone ICJ International Court of

The History of Disability Services in Higher Education

ERIC Educational Resources Information Center

Madaus, Joseph W.

2011-01-01

In 2002, Brinckerhoff, McGuire, and Shaw observed that the field of postsecondary education and disability services had "moved through its adolescence and was embarking on adulthood" (xiii). Indeed, the field had undergone rapid expansion nationwide in the prior 30 years and grew into a full-fledged profession within higher education (Jarrow…

Chemical and Photographic Evaluation of Rigid Explosive Transfer Lines.

DTIC Science & Technology

1984-05-01

and Kaplan , L. A., J. Org. Chem., Vol. 31, 1966, p. 857. 4. Dacons, J. C., Adolph, H. G., and Kpmlet, M. J., Heat Resistant Explosives, XIII...Sand Canyon Road % Saugus, CA 91351 Jet Propulsion Laboratory Attn: W. Gin 125-124 1 Rockwell International 4800 Oak Grove Drive Attn: L. Corvin ( MA2

Love, Charity, & Pope Leo XIII: A Leadership Paradigm for Catholic Education

ERIC Educational Resources Information Center

Davis, Henry J.

2015-01-01

The treatment of workers is an ongoing social issue affecting society. No organization is immune to questionable employee practices, including Catholic educational institutions. For Catholic leadership to fully embody its intended justice-based role, it must first be aware of the social teachings put forth by the Roman Catholic Church. In this…

Air Quality Side Event Proposal November 2016 GEO XIII Plenary in St. Petersburg, Russia

EPA Science Inventory

The Group on Earth Observations (GEO), which EPA has participated in since 2003, has put out a call for Side Events for its thirteenth annual international Plenary Meeting which is in St. Petersburg, Russia this year during November, 2016. EPA has put on Side Events on Air Quali...

Military Review. Volume 80, Number 4, July-August 2000

DTIC Science & Technology

2000-08-01

Politics, Book 7, written in 350 B.C., trans. Benjamin Jowett, xiii, 1331 b24b39. 3.Stephen Covey, The 7 Habits of Highly Effective People : Restoring the...daily activities of subordinates. Stephen Covey, The 7 Habits of Highly Effective People : Restoring the Character Ethic, uses the notion of alignment to

75 FR 44144 - Washington: Final Authorization of State Hazardous Waste Management Program Revisions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-28

....19. 400(3)(c)(xiii)(A) Correction--the 265.300 Subpart word N--Landfills, carbonaceous related... recycling Subpart G exception from related; closure and 264.140, financial 265.140 Subpart responsibility H...) Correction--chang 264.143. e ``resource reclamation units'' to ``recycling units''. 620(4)(d)(iv...

The Mississippi River Campaign 1862-1863: The Impact of Climate and Pathogens on Operational Art at the Port Hudson Siege

DTIC Science & Technology

2017-04-13

48 1 Introduction Sun Tzu , for one, advised commanders to, “camp on hard ground, the army...51 Bibliography ...Society Papers Volume XIII January to December 1885 (Richmond, VA: The Society, 1891), 329; Bell, 31. 248 Bell, 30. 52 Bibliography Army Doctrine

Apollo XIII Spacecraft - Splashdown - South Pacific Ocean

NASA Image and Video Library

1970-04-17

S70-35652 (17 April 1970) --- The Apollo 13 spacecraft heads toward a splashdown in the South Pacific Ocean. The Apollo 13 Command Module splashed down in the South Pacific at 12:07:44 p.m., April 17, 1970. Note the capsule and its parachutes just visible against a gap in the dark clouds.

[Growth of the neurocranium].

PubMed

Hodacová, Z; Skalská, H

1998-01-01

The present study demonstrates the results of evaluation of growth changes of the neurocranium in a set of 98 human skulls of immature individuals aged 6-18/20/ years from the XIII.-XVIII. century. Craniometric values were matched with the corresponding values measured on the skulls of the same age groups from the IX. century and IX.-XII. centuries.

Development of an NPS Middle Ultraviolet Spectrograph (Mustang) Electronic Interface

DTIC Science & Technology

1991-12-01

connecting coaxial shield ................................ 140 xiii Figure 7-12 Encode Command Signal (top) and Video Data Signal (bottom) after connecting...coaxial shield ................................................ 142 Figure 7-13 Data Ready Signal (top) and Video Data Signal (bottom) after...connecting coaxial shield ....................................................... 142 Figure 7-14 Word Clock (top) and Gated Enable Signal Rising Edge (bottom

A novel Sarcocystis neurona genotype XIII is associated with severe encephalitis in an unexpectedly broad range of marine mammals from the northeastern Pacific Ocean.

PubMed

Barbosa, Lorraine; Johnson, Christine K; Lambourn, Dyanna M; Gibson, Amanda K; Haman, Katherine H; Huggins, Jessica L; Sweeny, Amy R; Sundar, Natarajan; Raverty, Stephen A; Grigg, Michael E

2015-08-01

Sarcocystis neurona is an important cause of protozoal encephalitis among marine mammals in the northeastern Pacific Ocean. To characterise the genetic type of S. neurona in this region, samples from 227 stranded marine mammals, most with clinical or pathological evidence of protozoal disease, were tested for the presence of coccidian parasites using a nested PCR assay. The frequency of S. neurona infection was 60% (136/227) among pinnipeds and cetaceans, including seven marine mammal species not previously known to be susceptible to infection by this parasite. Eight S. neurona fetal infections identified this coccidian parasite as capable of being transmitted transplacentally. Thirty-seven S. neurona-positive samples were multilocus sequence genotyped using three genetic markers: SnSAG1-5-6, SnSAG3 and SnSAG4. A novel genotype, referred to as Type XIII within the S. neurona population genetic structure, has emerged recently in the northeastern Pacific Ocean and is significantly associated with an increased severity of protozoal encephalitis and mortality among multiple stranded marine mammal species. Published by Elsevier Ltd.

Energy levels, lifetimes, and transition rates for the selenium isoelectronic sequence Pd XIII-Te XIX, Xe XXI-Nd XXVII, W XLI

NASA Astrophysics Data System (ADS)

Wang, K.; Yang, X.; Chen, Z. B.; Si, R.; Chen, C. Y.; Yan, J.; Zhao, X. H.; Dang, W.

2017-09-01

Energy levels, wavelengths, lifetimes, oscillator strengths, and electric dipole (E1), magnetic dipole (M1), electric quadrupole (E2), magnetic quadrupole (M2) transition rates among the 46 fine structure levels belonging to the ([ Ar ] 3d10) 4s2 4p4, ([ Ar ] 3d10) 4s2 4p3 4 d, and ([ Ar ] 3d10) 4 s 4p5 configurations for the selenium isoelectronic sequence Pd XIII-Te XIX, Xe XXI-Nd XXVII, W XLI are reported. These data are determined in the multi-configuration Dirac-Fock (MCDF) approach, in which relativistic effects, main electron correlations within the n = 7 complex, Breit interaction (BI), and quantum electrodynamic (QED) corrections are included. The many-body perturbation theory (MBPT) method is also employed as an independent calculation to confirm the present accuracy, taking W XLI as an example. Comparisons and analysis are made between the present results and available experimental and theoretical ones, and good agreements are obtained. These accurate data are expected to be useful in nuclear fusion research and astrophysical applications.

Intrinsic thermodynamics of ethoxzolamide inhibitor binding to human carbonic anhydrase XIII

PubMed Central

2012-01-01

Background Human carbonic anhydrases (CAs) play crucial role in various physiological processes including carbon dioxide and hydrocarbon transport, acid homeostasis, biosynthetic reactions, and various pathological processes, especially tumor progression. Therefore, CAs are interesting targets for pharmaceutical research. The structure-activity relationships (SAR) of designed inhibitors require detailed thermodynamic and structural characterization of the binding reaction. Unfortunately, most publications list only the observed thermodynamic parameters that are significantly different from the intrinsic parameters. However, only intrinsic parameters could be used in the rational design and SAR of the novel compounds. Results Intrinsic binding parameters for several inhibitors, including ethoxzolamide, trifluoromethanesulfonamide, and acetazolamide, binding to recombinant human CA XIII isozyme were determined. The parameters were the intrinsic Gibbs free energy, enthalpy, entropy, and the heat capacity. They were determined by titration calorimetry and thermal shift assay in a wide pH and temperature range to dissect all linked protonation reaction contributions. Conclusions Precise determination of the inhibitor binding thermodynamics enabled correct intrinsic affinity and enthalpy ranking of the compounds and provided the means for SAR analysis of other rationally designed CA inhibitors. PMID:22676044

In-situ AFM measurement of single fibrin fiber stiffness before and after addition of Factor XIII

NASA Astrophysics Data System (ADS)

Houser, John; O'Brien, E. Timothy; Lord, Susan T.; Superfine, Richard; Falvo, Michael R.

2008-10-01

Fibrin fibers are the main structural component of blood clots. Ligation of fibrin by native Factor XIII (FXIII) serves to fine tune the mechanical properties of the clot. Mechanical alteration is important because a clot must be stiff enough to resist forces from blood flow but compliant enough to prevent embolism (fracture). Cone and Plate measurements of fibrin gels, which represent the vast majority of mechanical measurements on fibrin, show that FXIII increases clot stiffness. More recently, measurements on individual fibrin fibers show that they exhibit remarkable extensibility, breaking at strains up to 300%. As of yet, the origin of this extensibility is not fully understood. The different responses of ligated and unligated fibrin fibers can give us clues as to it's mechanism of extension. We use a combined fluorescence/atomic force microscope to stretch individual, isolated, fibrin fibers and then compare force extension curves of the same fiber before and after addition of FXIII. We found up to a 3.5-fold increase in fiber stiffness after addition of FXIII. We also show stiffening of individual fibrin fibers after crosslinking by gluteraldehyde.

A novel Sarcocystis neurona genotype XIII is associated with severe encephalitis in an unexpectedly broad range of marine mammals from the northeastern Pacific Ocean

PubMed Central

Barbosa, Lorraine; Johnson, Christine K.; Lambourn, Dyanna M.; Gibson, Amanda K.; Haman, Katherine H.; Huggins, Jessica L.; Sweeny, Amy R.; Sundar, Natarajan; Raverty, Stephen A.; Grigg, Michael E.

2015-01-01

Sarcocystis neurona is an important cause of protozoal encephalitis among marine mammals in the northeastern Pacific Ocean. To characterize the genetic type of S. neurona in this region, samples from 227 stranded marine mammals, most with clinical or pathological evidence of protozoal disease, were tested for the presence of coccidian parasites using a nested PCR assay. The frequency of S. neurona infection was 60% (136/227) among pinnipeds and cetaceans, including seven marine mammal species not previously known to be susceptible to infection by this parasite. Eight S. neurona fetal infections identified this coccidian parasite as capable of being transmitted transplacentally. Thirty-seven S. neurona-positive samples were multilocus sequence genotyped using three genetic markers: SnSAG1-5-6, SnSAG3 and SnSAG4. A novel genotype, referred to as Type XIII within the S. neurona population genetic structure, has emerged recently in the northeastern Pacific Ocean and is significantly associated with an increased severity of protozoal encephalitis and mortality among multiple stranded marine mammal species. PMID:25997588

The Cryogenic Near Infrared Spectropolarimeter for the Daniel K. Inouye Solar Telescope

NASA Astrophysics Data System (ADS)

Fehlmann, Andre; Giebink, Cindy; Kuhn, Jeffrey Richard; Mickey, D. L.; Scholl, Isabelle

2017-08-01

The Cryogenic Near Infrared Spectropolarimeter is one of the first light instruments for the Daniel K. Inouye Solar Telescope. This dual-beam instrument, which is currently characterized at the University of Hawaii’s Institute for Astronomy, is designed to sensitively measure the solar spectrum at wavelengths from 1 to 5 μm. The high dynamic range of the spectrograph and its context imager will provide sensitive data of the solar disk in the CO bands; unique observations of the low corona and unprecedented measurements of the coronal magnetic field. Observations near the limb and in the corona will greatly benefit from DKIST’s limb occulting system. The initial suite of filters includes selecting filters for the spectrograph at He I / Fe XIII 1080 nm, Si X 1430 nm, Si IX 3934 nm and CO 4651 nm as well as narrow band filters for the context imager at Fe XIII 1074.7 nm, He I 1083.0, Si X 1430.0 nm and J band 1250 nm. In this paper we will present an update on the ongoing instrument characterization and CryoNIRSP’s capabilities.

Tabulation of comet observations.

NASA Astrophysics Data System (ADS)

1993-01-01

Concerning comets: 1973 XII Kohoutek, 1975 IX Kobayashi-Berger-Milon, 1976 VI West, 1976 XI P/d'Arrest, 1977 XIV Kohler, 1979 X Bradfield, 1980 X P/Stephan-Oterma, 1980 XV Bradfield, 1981 II Panther, 1982 VI Austin, 1983 V Sugano-Saigusa-Fujikawa, 1983 VII IRAS-Araki-Alcock, 1983 XIII P/Kopff, 1984 XIII Austin, 1984 XXIII Levy-Rudenko, 1985 XIII P/Giacobini-Zinner, 1985 XVII Hartley-Good, 1985 XIX Thiele, 1986 I P/Boethin, 1986 III P/Halley, 1986 XVIII Terasako, 1987 II Sorrells, 1987 III Nishikawa-Takamizawa-Tago, 1987 X P/Grigg-Skjellerup, 1987 XXIII Rudenko, 1987 XXIX Bradfield, 1987 XXXII McNaught, 1987 XXXIII P/Borrelly, 1988 IV Furuyama, 1988 V Liller, 1988 XIV P/Tempel 2, 1988 XV Machholz, 1988 XX Yanaka, 1988 XXIV Yanaka, 1989 X P/Brorsen-Metcalf, 1989 XV P/Schwassmann-Wachmann 1, 1989 XIX Okazaki-Levy-Rudenko, 1989 XXI Helin-Roman-Alu, 1989 XXII Aarseth-Brewington, 1990 III Černis-Kiuchi-Nakamura, 1990 VI Skorichenko-George, 1990 VIII P/Schwassmann-Wachmann 3, 1990 IX P/Peters-Hartley, 1990 X P/Wild 4, 1990 XIV P/Honda Mrkos-Pajdušáková, 1990 XVII Tsuchiya-Kiuchi, 1990 XXI P/Encke, 1990 XXVI Arai, 1991 XI P/Levy, 1991 XV P/Hartley 2, 1991 XVI P/Wirtanen, 1991 XVII P/Arend-Rigaux, 1991 XXI P/Faye, 1991 XXIII P/Shoemaker 1, 1991 XXIV Shoemaker-Levy, 1991l Helin-Lawrence, 1991ο P/Chernykh, 1991r Helin-Alu, 1991a1 Shoemaker-Levy, 1991g1 Zanotta-Brewington, 1991h1 Mueller, 1912d Tanaka-Machholz, 1992f P/Shoemaker-Levy 8, 1992k Machholz, 1992l P/Giclas, 1992p P/Brewington, 1992q Helin-Lawrence, 1992s P/Ciffréo, 1992t P/Swift-Tuttle, 1992u P/Väisälä, 1992x P/Schaumasse, 1992y Shoemaker, 1992a1 Ohshita, 1993a Mueller, P/Smirnova-Chernykh.

Crystal structure of laser-induced subsurface modifications in Si

DOE Office of Scientific and Technical Information (OSTI.GOV)

Verburg, P. C.; Smillie, L. A.; Römer, G. R. B. E.

2015-06-04

Laser-induced subsurface modification of dielectric materials is a well-known technology. Applications include the production of optical components and selective etching. In addition to dielectric materials, the subsurface modification technology can be applied to silicon, by employing near to mid-infrared radiation. An application of subsurface modifications in silicon is laser-induced subsurface separation, which is a method to separate wafers into individual dies. Other applications for which proofs of concept exist are the formation of waveguides and resistivity tuning. However, limited knowledge is available about the crystal structure of subsurface modifications in silicon. In this paper, we investigate the geometry and crystalmore » structure of laser-induced subsurface modifications in monocrystalline silicon wafers. Finally, in addition to the generation of lattice defects, we found that transformations to amorphous silicon and Si-iii/Si-xii occur as a result of the laser irradiation.« less

Activated Dual Specificity Lymphocytes and Their Methods of Use | NCI Technology Transfer Center | TTC

Cancer.gov

Researchers at the NCI have developed a method of using genetic modifications to generate leukocytes with multiple specificities. This technology represents a potential therapy for a wide variety of malignancies, and because of the genetic modification used, this therapy will be applicable to patients of any MHC type.

Educators' Percpetions of the Substitution, Augmentation, Modification, Redefinition Model for Technology Integration

ERIC Educational Resources Information Center

Savignano, Mark Angelo

2017-01-01

The Substitution, Augmentation, Modification, Redefinition (SAMR) model has been introduced (Puentedura, 2006) claims that use of technology could predict student outcomes. School districts and educational institutions have been adopting this model in hopes to enhance the educational experience and outcomes for their students (SAMR Model, n.d.).…

A novel modification of the Turing test for artificial intelligence and robotics in healthcare.

PubMed

Ashrafian, Hutan; Darzi, Ara; Athanasiou, Thanos

2015-03-01

The increasing demands of delivering higher quality global healthcare has resulted in a corresponding expansion in the development of computer-based and robotic healthcare tools that rely on artificially intelligent technologies. The Turing test was designed to assess artificial intelligence (AI) in computer technology. It remains an important qualitative tool for testing the next generation of medical diagnostics and medical robotics. Development of quantifiable diagnostic accuracy meta-analytical evaluative techniques for the Turing test paradigm. Modification of the Turing test to offer quantifiable diagnostic precision and statistical effect-size robustness in the assessment of AI for computer-based and robotic healthcare technologies. Modification of the Turing test to offer robust diagnostic scores for AI can contribute to enhancing and refining the next generation of digital diagnostic technologies and healthcare robotics. Copyright © 2014 John Wiley & Sons, Ltd.

77 FR 76871 - Approval and Promulgation of Implementation Plans; State of Colorado; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... nitrogen oxides. xiii. The initials NPS mean or refer to National Park Service. xiv. The initials PM 2.5..., nitrogen deposition, and mercury emissions and deposition. The State spent considerable time and conducted sequential and extended hearings to develop a plan which seeks to balance a number of variables beyond those...

Basic Needs and Education in Portugal. The Portugal Project. Document No. XIII.

ERIC Educational Resources Information Center

Erasmie, Thord

The aim of this study was to describe and compare the socio-economic factors that can be expected to influence the education system in Portugal, where urbanization has been very slow. The report examines basic needs in Portugal's 18 districts and makes recommendations about resource allocation to planners of adult education programs. Extensive…

The ELISE II Project: A Digital Image Library for Europe.

ERIC Educational Resources Information Center

Strunz, Bob; Waters, Mairead

This paper describes the progress made under the ELISE II electronic image library project from a technical standpoint. The ELISE II project is a European-wide initiative that aims to provide a comprehensive electronic image library service for Europe. It is funded under the European Commission, DG XIII-E, Telematics for Libraries Initiative. The…

Speckle Interferometry at the US Naval Observatory. XIII

DTIC Science & Technology

2007-10-01

18443+3940 ............................. STF 2382 AB 6.394 348.9 2.35 1 0.3 0.06 Mason et al. (2004a) 0.2 0.03 Novakovic & Todorovic (2005) 18443+3940...1952, Bull. Astron. Paris, 16, 263 Novakovic , B., & Todorovic, N. 2005, Circ. d’Inf. 157 Olevic, D. 2002, Circ. d’Inf. 147 Olevic, D., & Cvetkovic, Z

Russian Function Catalog and Rolebooks. Methods for Determining Language Objectives and Criteria, Volume XIII.

ERIC Educational Resources Information Center

Setzler, Hubert H., Jr.; And Others

A Russian Function Catalog and Instructor and Advisor Rolebooks for Russian are presented. The catalog and rolebooks are part of the communication/language objectives-based system (C/LOBS), which supports the front-end analysis efforts of the Defense Language Institute Foreign Language Center. The C/LOBS projects, which is described in 13 volumes…

AUTOMOTIVE DIESEL MAINTENANCE 2. UNIT XIII, BATTERY SERVICE AND TESTING PROCEDURES--PART II.

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 25-MODULE COURSE IS DESIGNED TO FAMILIARIZE THE TRAINEE WITH PROCEDURES FOR SERVICING LEAD-ACID STORAGE BATTERIES USED ON DIESEL POWERED EQUIPMENT. TOPICS ARE (1) ELECTROLYTE AND SPECIFIC GRAVITY, (2) BATTERY CHARGING, (3) STORAGE BATTERY TYPES AND DESIGN, (4) BATTERY CAPACITY RATINGS, (5) BATTERY INSTALLATION, SERVICING, AND…

Osteogenesis Imperfecta

PubMed Central

Sam, Justin Easow; Dharmalingam, Mala

2017-01-01

Osteogenesis imperfecta is a common heritable connective tissue disorder. Nearly ninety percent are due to Type I collagen mutations. Type I-IV are autosomal dominant, and Type VI–XIII are autosomal recessive. They are Graded 1-5 based on severity. Genomic testing is done by collagen analysis from fibroblasts. The mainstay of treatment is bisphosphonate therapy. The prognosis is variable. PMID:29285457

Energy Policy Act Transportation Rate Study: Final Report on Coal Transportation

EIA Publications

2000-01-01

This is the final in a series of reports prepared for the U.S. Congress by the Secretary of Energy on coal distribution and transportation rates as mandated by Title XIII, Section 1340, Establishment of Data Base and Study of Transportation Rates, of the Energy Policy Act of 1992 (P.L. 102-486).

Improving Soldier and Unit Effectiveness with the Stryker Brigade Combat Team Warfighters’ Forum

DTIC Science & Technology

2011-01-01

Figures S.1. Differences Attributable to the ICEA Handbook During a Training Rotation . . . . . . . . . . . xiii 2.1. Distribution of Respondents...of Differences Attributable to the Handbook During a Training Rotation ...in an SBCT that received the ICEA did significantly better on tactical tasks during combat training center rotations than platoons that did not

Public health. Gates Foundation on big funding spree.

PubMed

Hagmann, M

2000-08-11

The Bill and Melinda Gates Foundation dished up $200 million in grants for scientists in various fields late last month, including research into malaria and tuberculosis. The foundation kicked off its spending spree in mid-July at the XIII International AIDS Conference in Durban, South Africa, by announcing several AIDS/HIV-related grants totaling $90 million.

38 CFR 17.81 - Contracts for residential treatment services for veterans with alcohol or drug dependence or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... the Department of Veterans Affairs, Office of Regulations Management (02D), Room 1154, 810 Vermont... management must agree that all the other residents in any building housing veterans will also have such...) Support for the individual desire for sobriety (alcohol/drug abuse-free life style). (xiii) Opportunities...

Carrascolendas: Evaluation of a Spanish/English Educational Television Series Within Region XIII. Final Report. Evaluation Component.

ERIC Educational Resources Information Center

Van Wart, Geraldine

This fourth year evaluation reports the effects and usage of "Carrascolendas," a children's television series in Spanish and English. Research was conducted in Texas schools and encompassed three phases: a field experiment to measure learning effects; attitudinal surveys among teachers, parents, and children; and a process evaluation of…

7 CFR 2.22 - Under Secretary for Marketing and Regulatory Programs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Consultative Group to Eliminate the Use of Child Labor and Forced Labor in Imported Agricultural Products. (2..., control or eradicate foot-and-mouth disease and other foreign animal diseases (21 U.S.C. 113a); (xiii) The... States in control and eradication of plant and animal diseases and pests; (xv) The Federal Noxious Weed...

7 CFR 2.22 - Under Secretary for Marketing and Regulatory Programs.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Consultative Group to Eliminate the Use of Child Labor and Forced Labor in Imported Agricultural Products. (2..., control or eradicate foot-and-mouth disease and other foreign animal diseases (21 U.S.C. 113a); (xiii) The... States in control and eradication of plant and animal diseases and pests; (xv) The Federal Noxious Weed...

7 CFR 2.22 - Under Secretary for Marketing and Regulatory Programs.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Consultative Group to Eliminate the Use of Child Labor and Forced Labor in Imported Agricultural Products. (2..., control or eradicate foot-and-mouth disease and other foreign animal diseases (21 U.S.C. 113a); (xiii) The... States in control and eradication of plant and animal diseases and pests; (xv) The Federal Noxious Weed...

7 CFR 2.22 - Under Secretary for Marketing and Regulatory Programs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Consultative Group to Eliminate the Use of Child Labor and Forced Labor in Imported Agricultural Products. (2..., control or eradicate foot-and-mouth disease and other foreign animal diseases (21 U.S.C. 113a); (xiii) The... States in control and eradication of plant and animal diseases and pests; (xv) The Federal Noxious Weed...

78 FR 15988 - Self-Regulatory Organizations; the NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-13

.... ``dark venues'' or ``dark pools''). QCST orders, pursuant to Rule 4758(a)(1)(A)(xiii), check the System for available shares and simultaneously route to select dark venues and to certain low cost exchanges... Web site ( http://www.sec.gov/rules/sro.shtml ). Copies of the submission, all subsequent amendments...

Improving Operational Effectiveness of Tactical Long Endurance Unmanned Aerial Systems (TALEUAS) by Utilizing Solar Power

DTIC Science & Technology

2014-06-01

Speed xiii TEK Total Energy Compensated TSP traveling salesman problem UAV unmanned aerial vehicle UDP user datagram protocol UKF unscented...discretized map, and use the map to optimally solve the navigation task. The optimal navigation solution utilizes the well-known “ travelling salesman problem ...2 C. FORMULATION OF THE PROBLEM .................................................. 3 D

Plasma assisted surface coating/modification processes - An emerging technology

NASA Technical Reports Server (NTRS)

Spalvins, T.

1987-01-01

A broad understanding of the numerous ion or plasma assisted surface coating/modification processes is sought. An awareness of the principles of these processes is needed before discussing in detail the ion nitriding technology. On the basis of surface modifications arising from ion or plasma energizing and interactions, it can be broadly classified as deposition of distinct overlay coatings (sputtering-dc, radio frequency, magnetron, reactive; ion plating-diode, triode) and surface property modification without forming a discrete coating (ion implantation, ion beam mixing, laser beam irradiation, ion nitriding, ion carburizing, plasma oxidation. These techniques offer a great flexibility and are capable in tailoring desirable chemical and structural surface properties independent of the bulk properties.

Plasma assisted surface coating/modification processes: An emerging technology

NASA Technical Reports Server (NTRS)

Spalvins, T.

1986-01-01

A broad understanding of the numerous ion or plasma assisted surface coating/modification processes is sought. An awareness of the principles of these processes is needed before discussing in detail the ion nitriding technology. On the basis of surface modifications arising from ion or plasma energizing and interactions, it can be broadly classified as deposition of distinct overlay coatings (sputtering-dc, radio frequency, magnetron, reactive; ion plating-diode, triode) and surface property modification without forming a discrete coating (ion implantation, ion beam mixing, laser beam irradiation, ion nitriding, ion carburizing, plasma oxidation). These techniques offer a great flexibility and are capable in tailoring desirable chemical and structural surface properties independent of the bulk properties.

75 FR 30268 - Airworthiness Directives; AeroSpace Technologies of Australia Pty Ltd Models N22B, N22S, and N24A...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... FAA-approved repair scheme/modification and incorporate the repair scheme/ modification. Due to FAA policy, the repair scheme/modification for crack damage must include an immediate repair of the crack. The repair scheme cannot be by repetitive inspection only. The repair scheme/modification may...

75 FR 10694 - Airworthiness Directives; AeroSpace Technologies of Australia Pty Ltd Models N22B, N22S, and N24A...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-09

... FAA-approved repair scheme/modification and incorporate the repair scheme/ modification. Due to FAA policy, the repair scheme/modification for crack damage must include an immediate repair of the crack. The repair scheme cannot be by repetitive inspection only. The repair scheme/modification may...

Economic Effects of Precipitation Enhancement in the Corn Belt.

NASA Astrophysics Data System (ADS)

Gapcia, Philip; Changnon, Stanley; Pinar, Musa

1990-01-01

Policy formulation in weather modification requires an understanding of the economic effects from altered weather. The focus of this study is to provide insight into the beneficiaries of a functioning weather modification technology when applied at various spatial and temporal levels. An econometric model which links the corn/scybean production to U.S. cattle, hog and poultry sectors is used to determine the effects of precipitation enhancement in the U.S. Corn Belt, a humid climatic region. A regional supply formulation permits assessment of weather modification on production, prices, revenues to producers, and savings in consumers expenditures on meat. The results provide insight into the distribution of economic effects, emphasize the importance of careful planning in the use of weather modification technology, and provide useful information on the roles of local, state, and federal governments in the support of weather modification.

Embedding technology into inter-professional best practices in home safety evaluation.

PubMed

Burns, Suzanne Perea; Pickens, Noralyn Davel

2017-08-01

To explore inter-professional home evaluators' perspectives and needs for building useful and acceptable decision-support tools for the field of home modifications. Twenty semi-structured interviews were conducted with a range of home modification professionals from different regions of the United States. The interview transcripts were analyzed with a qualitative, descriptive, perspective approach. Technology supports current best practice and has potential to inform decision making through features that could enhance home evaluation processes, quality, efficiency and inter-professional communication. Technological advances with app design have created numerous opportunities for the field of home modifications. Integrating technology and inter-professional best practices will improve home safety evaluation and intervention development to meet client-centred and societal needs. Implications for rehabilitation Understanding home evaluators technology needs for home safety evaluations contributes to the development of app-based assessments. Integrating inter-professional perspectives of best practice and technological needs in an app for home assessments improves processes. Novice and expert home evaluators would benefit from decision support systems embedded in app-based assessments. Adoption of app-based assessment would improve efficiency while remaining client-centred.

Design definition study of NASA/Navy lift/cruise fan V/STOL aircraft

NASA Technical Reports Server (NTRS)

1975-01-01

Assessed are the risks associated with the lift/cruise fan technology V/STOL aircraft program. Three candidate concepts for the technology aircraft design approach are considered: the lowspeed only modification, the full performance modification, and the all new aircraft concepts. Survey results indicate that the lift/cruise fan technology aircraft program is feasible, from the standpoint of technical risk, with some evidence of uncertainty of meeting the planned schedule and relatively minor impact on estimated program costs.

A Keck/DEIMOS spectroscopic survey of the faint M31 satellites AndIX, AndXI, AndXII and AndXIII†

NASA Astrophysics Data System (ADS)

Collins, M. L. M.; Chapman, S. C.; Irwin, M. J.; Martin, N. F.; Ibata, R. A.; Zucker, D. B.; Blain, A.; Ferguson, A. M. N.; Lewis, G. F.; McConnachie, A. W.; Peñarrubia, J.

2010-10-01

We present the first spectroscopic analysis of the faint M31 satellite galaxies, AndXI and AndXIII, as well as a re-analysis of existing spectroscopic data for two further faint companions, AndIX (correcting for an error in earlier geometric modelling that caused a misclassification of member stars in previous work) and AndXII. By combining data obtained using the Deep Imaging Multi-Object Spectrograph (DEIMOS) mounted on the Keck II telescope with deep photometry from the Suprime-Cam instrument on Subaru, we have identified the most probable members for each of the satellites based on their radial velocities (precise to several down to i ~ 22), distance from the centre of the dwarf spheroidal galaxies (dSphs) and their photometric [Fe/H]. Using both the photometric and spectroscopic data, we have also calculated global properties for the dwarfs, such as systemic velocities, metallicities and half-light radii. We find each dwarf to be very metal poor ([Fe/H] ~ -2 both photometrically and spectroscopically, from their stacked spectrum), and as such, they continue to follow the luminosity-metallicity relationship established with brighter dwarfs. We are unable to resolve dispersion for AndXI due to small sample size and low signal-to-noise ratio, but we set a 1σ upper limit of σv < 4.5kms-1. For AndIX, AndXII and AndXIII we resolve velocity dispersions of σv = 4.5+3.6-3.4, 2.6+5.1-2.6 and 9.7+8.9-4.5kms-1, though we note that the dispersion for AndXIII is based on just three stars. We derive masses within the half-light radii for these galaxies of 6.2+5.3-5.1 × 106, 2.4+6.5-2.4 × 106 and 1.1+1.4-0.7 × 107Msolar, respectively. We discuss each satellite in the context of the Mateo relations for dSphs, and in reference to the universal halo profiles established for Milky Way dwarfs. Both AndIX and AndXII fall below the universal halo profiles of Walker et al., indicating that they are less massive than would be expected for objects of their half-light radius. When combined with the findings of McConnachie & Irwin, which reveal that the M31 satellites are twice as extended (in terms of both half-light and tidal radii) as their Milky Way counterparts, these results suggest that the satellite population of the Andromeda system could inhabit haloes that with regard to their central densities are significantly different from those of the Milky Way. The data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation. Based in part on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. ‡ E-mail: mlmc2@ast.cam.ac.uk

40 CFR Appendix Xiii to Part 86 - State Requirements Incorporated by Reference in Part 86 of the Code of Federal Regulations

Code of Federal Regulations, 2010 CFR

2010-07-01

... Specifications, adopted March 1, 1978, amended June 24, 1996, excluding paragraphs 2(b), 3.5, and 10. [62 FR... Vehicles, adopted November 24, 1981, amended June 24, 1996. (b) State of California; Air Resources Board... and Medium-Duty Vehicles, adopted June 24, 1996. (c) California Code of Regulations, Title 13...

Bridging Cultures and Traditions for Educational and International Development: Comparative Research, Dialogue and Difference

ERIC Educational Resources Information Center

Crossley, Michael

2008-01-01

Addressing the central theme of the XIII World Congress, the paper explores a number of contemporary theoretical, methodological and organisational developments in the field of comparative education. In doing so it draws upon the author's recent work and a selection of studies carried out in the South Pacific, the Caribbean and Africa. It is…

APOLLO XIII CREW - MISSION OPERATIONS CONTROL ROOM (MOCR) - APOLLO XII - LUNAR EXTRAVEHICULAR ACTIVITY (EVA) - MSC

NASA Image and Video Library

1969-11-21

S69-59525 (19 Nov. 1969) --- Overall view of activity in the Mission Operations Control Room (MOCR) in the Mission Control Center (MCC), Building 30, during the Apollo 12 lunar landing mission. When this picture was made the first Apollo 12 extravehicular activity (EVA) was being televised from the surface of the moon. Photo credit: NASA

Identification of Decision Support Concepts for the Planning of Air Force Immediate Contingencies Operations

DTIC Science & Technology

2010-03-01

that is becoming the norm in military operations, especial rapid response. Significance : The context of the work for this project focused on one...Time constraint variance ................................................................... 37 DRDC Valcartier CR 2010-353 xiii 3.5.8.1...employment activities that are normally recurring in nature and fall within the delegated authority of an appointed standing operational Commander

Employing Replay Connectors for SIEM Operator Education

DTIC Science & Technology

2013-09-01

BLANK xiii LIST OF ACRONYMS AND ABBREVIATIONS CORR Correlation Optimized Retention and Retrieval CII Critical Information Infrastructure GLBA...vast distances is now quicker and easier with the advancement in mobile computing devices and more ubiquitous connectivity and bandwidth. As a result...breakdown of the Critical Information Infrastructure (CII) is one of the core risks facing the international economy. The World Economic Forum

Wind-Tunnel Research Comparing Lateral Control Devices Particularly at High Angles of Attack XIII : Auxiliary Airfoils Used as External Ailerons

NASA Technical Reports Server (NTRS)

Weick, Fred E; Noyes, Richard W

1936-01-01

This is the thirteenth report on a series of systematic tests comparing lateral control devices with particular reference to their effectiveness at high angles of attack. The present wind tunnel tests were made to determine the most feasible locations for lateral control surfaces mounted externally to a rectangular Clark y wing.

Chippewa Indians: A Native American Curriculum Unit for the Third Grade. NATAM XIII.

ERIC Educational Resources Information Center

Kocur, Darlene

The document reports on an extension course taken in the spring of 1970 by public school teachers in the Columbia Heights Public School System via the University of Minnesota. The course, on American Indian education, included the usual on-campus requirements, as well as several lectures by guest Indians. Additionally, each teacher who enrolled in…

Water Quality Instructional Resources Information System (IRIS). A Compilation of Abstracts to Water Quality and Water Resources Materials. Supplement XIII.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus, OH. Information Reference Center for Science, Mathematics, and Environmental Education.

Compiled are abstracts and indexes to selected print and non-print materials related to wastewater treatment and water quality education and instruction, as well as materials related to pesticides, hazardous wastes, and public participation. Sources of abstracted/indexed materials include all levels of government, private concerns, and educational…

Waiving a requirement of clause 6(a) of rule XIII with respect to consideration of certain resolutions reported from the Committee on Rules, and providing for consideration of motions to suspend the rules.

THOMAS, 111th Congress

Rep. Hastings, Alcee L. [D-FL-23

2010-05-25

House - 05/28/2010 Pursuant to the provisions of H. Res. 1403, H. Res. 1392 is laid on the table. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Naval Arms Control: A Post-Cold War Reappraisal

DTIC Science & Technology

1991-06-01

94 A . BACKGRO UN D ......................................................................................... 94 B. WHY ...control, but that an appropriate time may come to exist in the future. For reasons why naval arms control may make more sense in the future, but not...34. Current Research on Peace And Violence. Tampere Peace Research Institute, Tampere Finland, Vol XIII, No. 2, 1990, pp. 65-86. For reasons why naval

Defining the Role and Responsibility of the Fire Service Within Homeland Security

DTIC Science & Technology

2010-03-01

Occupational Safety and Health NPS Naval Postgraduate School NRF National Response Framework OSHA Occupational Safety and Health Administration ...Kingdom USAR Urban Search and Rescue USFA United States Fire Administration USMA United States Military Academy xiii ACKNOWLEDGMENTS I want...Association (NFPA), the Occupational Safety and Health Administration (OSHA), the United States Fire Administration (USFA), and the National Institute for

40 CFR 721.5185 - Morpholine, 4-(1-oxo-2-propenyl)-.

Code of Federal Regulations, 2010 CFR

2010-07-01

...), (a)(5)(i), (a)(5)(ii), (a)(5)(iii), (a)(5)(xii), (a)(5)(xiii), (a)(5)(xiv), (a)(5)(xv), (a)(6)(v), (b) (concentration set at 0. 1 percent), and (c). The following material has been tested in accordance with the American Society for Testing Materials (ASTM) F739 method and found by EPA to satisfy the consent order's...

Influence of drying time and temperature on bond strength of contemporary adhesives to dentine.

PubMed

Garcia, Fernanda C P; Almeida, Júlio C F; Osorio, Raquel; Carvalho, Ricardo M; Toledano, Manuel

2009-04-01

To evaluate the bond strength (microTBS) of self-etching adhesives in different solvent evaporation conditions. Flat dentine surfaces from extracted human third molars were bonded with: (1) 2 two-steps self-etching adhesives (Clearfil SE Bond-CSEB); (Protect Bond-PB) and (2) 2 one-step self-etch systems (Adper Prompt L Pop-ADPLP); (Xeno III-XIII). Bonded dentine surfaces were air-dried for 5s, 20s, 30s or 40s at either 21 degrees C or 38 degrees C. Composite build-ups were constructed incrementally. After storage in water for 24h at 37 degrees C, the specimens were prepared for microtensile bond strength testing. Data were analyzed by two-way ANOVA and Student-Newman-Keuls at alpha=0.05. CSEB and PB performed better at warm temperature with only 20s of air-blowing. The bond strength increased when XIII was performed at warm temperature at 40s air-blowing. Extended air-blowing not affect the performance of ADPLP, except at 30s air-blowing time at warm temperature. The use of a warm air-dry stream seems to be a clinical tool to improve the bond strength to self-etching adhesives.

Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).

PubMed

Bialer, Meir; Johannessen, Svein I; Levy, René H; Perucca, Emilio; Tomson, Torbjörn; White, H Steve

2017-02-01

The Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII) took place in Madrid, Spain, on June 26-29, 2016, and was attended by >200 delegates from 31 countries. The present Progress Report provides an update on experimental and clinical results for drugs presented at the Conference. Compounds for which summary data are presented include an AED approved in 2016 (brivaracetam), 12 drugs in phase I-III clinical development (adenosine, allopregnanolone, bumetanide, cannabidiol, cannabidivarin, 2-deoxy-d-glucose, everolimus, fenfluramine, huperzine A, minocycline, SAGE-217, and valnoctamide) and 6 compounds or classes of compounds for which only preclinical data are available (bumetanide derivatives, sec-butylpropylacetamide, FV-082, 1OP-2198, NAX 810-2, and SAGE-689). Overall, the results presented at the Conference show that considerable efforts are ongoing into discovery and development of AEDs with potentially improved therapeutic profiles compared with existing agents. Many of the drugs discussed in this report show innovative mechanisms of action and many have shown promising results in patients with pharmacoresistant epilepsies, including previously neglected rare and severe epilepsy syndromes. Wiley Periodicals, Inc. © 2017 International League Against Epilepsy.

Germline Modification and Engineering in Avian Species

PubMed Central

Lee, Hong Jo; Lee, Hyung Chul; Han, Jae Yong

2015-01-01

Production of genome-edited animals using germline-competent cells and genetic modification tools has provided opportunities for investigation of biological mechanisms in various organisms. The recently reported programmed genome editing technology that can induce gene modification at a target locus in an efficient and precise manner facilitates establishment of animal models. In this regard, the demand for genome-edited avian species, which are some of the most suitable model animals due to their unique embryonic development, has also increased. Furthermore, germline chimera production through long-term culture of chicken primordial germ cells (PGCs) has facilitated research on production of genome-edited chickens. Thus, use of avian germline modification is promising for development of novel avian models for research of disease control and various biological mechanisms. Here, we discuss recent progress in genome modification technology in avian species and its applications and future strategies. PMID:26333275

Modifications of ORNL's computer programs MSF-21 and VTE-21 for the evaluation and rapid optimization of multistage flash and vertical tube evaporators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glueckstern, P.; Wilson, J.V.; Reed, S.A.

1976-06-01

Design and cost modifications were made to ORNL's Computer Programs MSF-21 and VTE-21 originally developed for the rapid calculation and design optimization of multistage flash (MSF) and multieffect vertical tube evaporator (VTE) desalination plants. The modifications include additional design options to make possible the evaluation of desalting plants based on current technology (the original programs were based on conceptual designs applying advanced and not yet proven technological developments and design features) and new materials and equipment costs updated to mid-1975.

Deceptive Tactics for Protecting Cities Against Vehicle Borne Improvised Explosive Devices

DTIC Science & Technology

2008-03-01

burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instruction, searching...INTENTIONALLY LEFT BLANK xiii LIST OF ABBREVIATIONS ABS Agent Based Simulation ANA Agent Network Attack DVF Detection Value Function GIS Geographic...any other behavior (than perceptive) may be advantageous to the attacker. - A communicative behavior proves particularly effective over time for the

Utopia, University and Architecture: A Journey that Changed the Design of Contemporary Universities

ERIC Educational Resources Information Center

Calvo-Sotelo, Pablo Campos

2006-01-01

In 1927, a group of advisors to King Alfonso XIII of Spain, led by the architect Modesto Lopez-Otero, set out for the United States and Canada. Previously, they had visited a number of European cities where they examined the medieval architectural form of some famous universities. Inspired by a Utopian vision, the journey to the New World studied…

The Federal Role in Improving Elementary and Secondary Education

DTIC Science & Technology

1993-05-01

programs of teacher educa- to consider the desirability and feasibility of S. ,,,,,,, ,,,,,, ,, .,. . , .,.. . SUMMARY Xiii national academic standards and...of a volun- ceived increased scrutiny during the 1980s be- tary system of assessments to measure the cause many people believed that the academic ...critics charging that they attain, as measured by standardized tests of have little empirical validity, that they may academic knowledge. These outcomes

Foundry Manual

DTIC Science & Technology

1958-01-01

ramming main part of mold or loose mold- ing sand used to support green cores while baking. Bail. Hoop or connection between the crane hook ...Crystallization 3 Heat Transfer 4 Gases in Metals 5 Summary 5 Chapter II. Designing a Casting 15 Strength Requirements 15 Stress Concentrations 15... Stress -Relief Anneal 180 Reasons for Heat Treatment 179 Aluminum 181 Iron and Steel 181 Monel 183 Summary 183 Chapter XIII. Composition of

Catholic Labor Education and the Association of Catholic Trade Unionists. Instructing Workers to Christianize the Workplace

ERIC Educational Resources Information Center

Lubienecki, Paul

2015-01-01

This article analyzes the effect of the American Catholic Church, through its program of specialized labor education, on the growth and development of organized labor in the twentieth century. With the proclamation of Pope Pius XI's encyclical Quadragesimo Anno (1931), he requested that the Church complete the work began by Pope Leo XIII in 1891…

Implementing and Evaluating an Innovative Approach to Simulation Training Acquisitions

DTIC Science & Technology

2006-01-01

busi- ness model, compares it with other approaches for buying simulations and simulation training, reviews economic theories relevant to the model, and...Points in Common with Other Approaches but Also Some Distinctive Characteristics ........................... 53 Contents vii CHAPTER FOUR The Economic ...Appropriate? .................... 65 4.3. Summary of Key Findings from Economic Theory .............. 72 xiii Summary In the wake of the failure of the Joint

Thermal Characterization of a Hall Effect Thruster

DTIC Science & Technology

2008-03-01

View Factor A = Area θ = Angle R = Distance xiii J = Radiosity q = Heat Transfer Rate W = Radiated Power U = Voltage C...summation rule. 1 1 N ij j F = =∑ (18) Radiosity (Ji) takes into account both radiation emitted and reflected from a surface. Analyzing radiation...exchanges between two surfaces is made easier with a few assumptions. Each surface is assumed isothermal and characterized by a uniform radiosity

Comparative Analysis of a High Bypass Turbofan Using a Pulsed Detonation Combustor

DTIC Science & Technology

2007-03-01

Thrust Specific Fuel Consumption . . . . . . . . . . . . . 67 xiii List of Abbreviations Abbreviation Page PDE Pulsed Detonation Engine...past ten years to develop pulsed det- onation engines ( PDE ) as a means of aircraft propulsion. Detonation combustion holds the promise of a more...aviation engine, and detonation creates more of it than previous aircraft engines. It is hoped that a marriage of the PDE with traditional

Tourism in Peru: The Missing Strategy for Economic and Social Development

DTIC Science & Technology

2006-06-01

Lima , 1970-1996.......................................12 xii THIS PAGE INTENTIONALLY LEFT BLANK xiii...time. Not two miles outside of Lima did things not only change, but they changed drastically. High rise buildings, upscale hotels, and very chic...natural resources. This is the case for Peru. Not only does the country hold a wealth of minerals, but it also possesses a plethora of beaches

Full-Authority Fault-Tolerant Electronic Engine Control System for Variable Cycle Engines.

DTIC Science & Technology

1982-04-01

single internally self-checked VLSI micro - processor . The selected configuration is an externally checked pair of com- mercially available...Electronic Engine Control FPMH Failures per Million Hours FTMP Fault Tolerant Multi- Processor FTSC Fault Tolerant Spaceborn Computer GRAMP Generalized...Removal * MTBR Mean Time Between Repair MTTF Mean Time to Failure xiii List of Abbreviations (continued) - NH High Pressure Rotor Speed O&S Operating

Understanding the Dynamic System of Terrorist-Government Interaction

DTIC Science & Technology

2003-03-01

organizations out of support or for services rendered (Department of State, 2002:65; Wallace, 2003:2). However, financial support does not have to be in...America’s critical infrastructure encompasses a large number of sectors[:]” agriculture, food, water, public health, emergency services , government...military, international law enforcement community, or the U.S. or international intelligence services (Department of State, 2002:vii-xiii). In fact

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (74th, Boston, Massachusetts, August 7-10, 1991). Part XIII: Studies on Television.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Studies on Television section of the proceedings contains the following 16 papers: "Television and the Cultivation of Perceptions about Racial Integration" (Paul Delva and others); "Breaking the News: The Ideology of Television News" (Paul Belgrade); "Whittle's Channel One and CNN's Newsroom: A Systematic Pilot Study…

Analysis of Selected Enhancements for Soil Vapor Extraction

DTIC Science & Technology

1997-09-01

Inches per second ACRONYMS AND ABBREVIATIONS (Continued) xiii ISB In situ bioremediation JFK John F. Kennedy Airport K Hydraulic conductivity KAI KAI...wells by an applied vacuum. RFH is effective for treating VOCs in low-permeability soil in the vadose zone. Electrical Resistance Heating : This... applied vacuum. However, application of steam injection/stripping systems is limited to medium- to high-permeability soils. ER heating is more

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (76th, Kansas City, Missouri, August 11-14, 1993). Part XIII: Miscellaneous Studies.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Miscellaneous Studies section of this collection of conference presentations contains the following 12 papers: "Revelatory Silences: A Critical Analysis of the Structuring Absences in Sydney Pollack's 'Out of Africa'" (Brenda Cooper and David Descutner); "The Cox Fight with the FCC: Gamesmanship, Hidden Agendas, and Personal…

Stereo photo series for quantifying natural fuels.Volume XIII: grasslands, shrublands, oak-bay woodlands, and eucalyptus forests in the East Bay of California.

Treesearch

Clinton S. Wright; Robert E. Vihnanek

2014-01-01

Four series of photographs display a range of natural conditions and fuel loadings for grassland, shrubland, oak-bay woodland, and eucalyptus forest ecosystems on the eastern slopes of the San Francisco Bay area of California. Each group of photos includes inventory information summarizing vegetation composition, structure, and loading; woody material loading and...

Design and Implementation of a Motor Incremental Shaft Encoder

DTIC Science & Technology

2008-09-01

SDC Student Design Center VHDL Verilog Hardware Description Language VSC Voltage Source Converters ZCE Zero Crossing Event xiii EXECUTIVE...student to make accurate predictions of voltage source converters ( VSC ) behavior via software simulation; these simulated results could also be... VSC ), and several other off-the-shelf components, a circuit board interface between FPGA and the power source, and a desktop computer [1]. Now, the

With Agriculture Knowledge and Wisdom (Me Ka Ike Ame Ka Na'auao). Proceedings of the Annual Western Region Agricultural Education Research Meeting (Honolulu, Hawaii, April 13-16, 1994). Volume XIII, Number 1.

ERIC Educational Resources Information Center

Cox, David E., Ed.; Walton, Frank C., Ed.

This proceedings includes the following papers: "Examining Learning Styles of Students in College of Agriculture" (Torres, Cano); "Developing a Scale to Research and Evaluate Youth Leadership Life Skills Development" (Seevers, Dormody, Clason); "Predicting Youth Leadership Life Skills Development among FFA (Future Farmers…

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (75th, Montreal, Quebec, Canada, August 5-8, 1992). Part XIII: Magazines.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Magazine section of these proceedings contains the following six papers: "An Analysis of 'Magazine Type': Toward an Empirically Based Typology of Magazines and Non-Newspaper Periodicals" (Marcia R. Prior-Miller); "'Redbook': Changes in Attitude and Advice 1965-1990" (Jennifer Harbour); "A Quantitative Analysis of U.S.…

AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT XIII, I--MAINTAINING THE FUEL SYSTEM (PART III), CUMMINS DIESEL ENGINES, II--RADIATOR SHUTTER SYSTEM.

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE CONSTRUCTION, OPERATION, AND MAINTENANCE OF THE DIESEL ENGINE FUEL AND RADIATOR SHUTTER SYSTEMS. TOPICS ARE (1) MORE ABOUT THE CUMMINS FUEL SYSTEM, (2) CALIBRATING THE PT FUEL PUMP, (3) CALIBRATING THE FUEL INJECTORS, (4) UNDERSTANDING THE SHUTTER SYSTEM, (5) THE…

Scaling Bulk Data Analysis with Mapreduce

DTIC Science & Technology

2017-09-01

Submitted in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE IN COMPUTER SCIENCE from the NAVAL POSTGRADUATE SCHOOL September...2017 Approved by: Michael McCarrin Thesis Co-Advisor Marcus S. Stefanou Thesis Co-Advisor Peter J. Denning Chair, Department of Computer Science iii...98 xiii THIS PAGE INTENTIONALLY LEFT BLANK xiv List of Acronyms and Abbreviations CART Computer Analysis and Response Team DELV Distributed Environment

Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models.

PubMed

Uno, Narumi; Abe, Satoshi; Oshimura, Mitsuo; Kazuki, Yasuhiro

2018-02-01

Chromosome transfer technology, including chromosome modification, enables the introduction of Mb-sized or multiple genes to desired cells or animals. This technology has allowed innovative developments to be made for models of human disease and humanized animals, including Down syndrome model mice and humanized transchromosomic (Tc) immunoglobulin mice. Genome editing techniques are developing rapidly, and permit modifications such as gene knockout and knockin to be performed in various cell lines and animals. This review summarizes chromosome transfer-related technologies and the combined technologies of chromosome transfer and genome editing mainly for the production of cell/animal models of human disease and humanized animal models. Specifically, these include: (1) chromosome modification with genome editing in Chinese hamster ovary cells and mouse A9 cells for efficient transfer to desired cell types; (2) single-nucleotide polymorphism modification in humanized Tc mice with genome editing; and (3) generation of a disease model of Down syndrome-associated hematopoiesis abnormalities by the transfer of human chromosome 21 to normal human embryonic stem cells and the induction of mutation(s) in the endogenous gene(s) with genome editing. These combinations of chromosome transfer and genome editing open up new avenues for drug development and therapy as well as for basic research.

Effects of ionospheric modification on system performance

NASA Astrophysics Data System (ADS)

Ganguly, Suman

1989-12-01

Controlled ionospheric modification can be used for disrupting as well as facilitating communication and radar systems. After briefly describing the results achieved with the present day ionospheric modification facilities, a scenario is presented for the generation of strong and significant ionospheric modification. A few schemes are presented for the development of modern high power facilities using the state of the art technology and then the impact of such facilities on the system performance is described.

A general strategy for the ultrafast surface modification of metals.

PubMed

Shen, Mingli; Zhu, Shenglong; Wang, Fuhui

2016-12-07

Surface modification is an essential step in engineering materials that can withstand the increasingly aggressive environments encountered in various modern energy-conversion systems and chemical processing industries. However, most traditional technologies exhibit disadvantages such as slow diffusion kinetics, processing difficulties or compatibility issues. Here, we present a general strategy for the ultrafast surface modification of metals inspired by electromigration, using aluminizing austenitic stainless steel as an example. Our strategy facilitates the rapid formation of a favourable ductile surface layer composed of FeCrAl or β-FeAl within only 10 min compared with several hours in conventional processes. This result indicates that electromigration can be used to achieve the ultrafast surface modification of metals and can overcome the limitations of traditional technologies. This strategy could be used to aluminize ultra-supercritical steam tubing to withstand aggressive oxidizing environments.

A multiplexed system for quantitative comparisons of chromatin landscapes

PubMed Central

van Galen, Peter; Viny, Aaron D.; Ram, Oren; Ryan, Russell J.H.; Cotton, Matthew J.; Donohue, Laura; Sievers, Cem; Drier, Yotam; Liau, Brian B.; Gillespie, Shawn M.; Carroll, Kaitlin M.; Cross, Michael B.; Levine, Ross L.; Bernstein, Bradley E.

2015-01-01

Genome-wide profiling of histone modifications can provide systematic insight into the regulatory elements and programs engaged in a given cell type. However, conventional chromatin immunoprecipitation and sequencing (ChIP-seq) does not capture quantitative information on histone modification levels, requires large amounts of starting material, and involves tedious processing of each individual sample. Here we address these limitations with a technology that leverages DNA barcoding to profile chromatin quantitatively and in multiplexed format. We concurrently map relative levels of multiple histone modifications across multiple samples, each comprising as few as a thousand cells. We demonstrate the technology by monitoring dynamic changes following inhibition of P300, EZH2 or KDM5, by linking altered epigenetic landscapes to chromatin regulator mutations, and by mapping active and repressive marks in purified human hematopoietic stem cells. Hence, this technology enables quantitative studies of chromatin state dynamics across rare cell types, genotypes, environmental conditions and drug treatments. PMID:26687680

Proteomic analyses of the environmental toxicity of carcinogenic chemicals

EPA Science Inventory

Protein expression and posttranslational modifications consistently change in response to the exposure to environmental chemicals. Recent technological advances in proteomics provide new tools for more efficient characterization of protein expression and posttranslational modific...

Computer Access. Tech Use Guide: Using Computer Technology.

ERIC Educational Resources Information Center

Council for Exceptional Children, Reston, VA. Center for Special Education Technology.

One of nine brief guides for special educators on using computer technology, this guide focuses on access including adaptations in input devices, output devices, and computer interfaces. Low technology devices include "no-technology" devices (usually modifications to existing devices), simple switches, and multiple switches. High technology input…

Improving yield and reliability of FIB modifications using electrical testing

NASA Astrophysics Data System (ADS)

Desplats, Romain; Benbrik, Jamel; Benteo, Bruno; Perdu, Philippe

1998-08-01

Focused Ion Beam technology has two main areas of application for ICs: modification and preparation for technological analysis. The most solicited area is modification. This involves physically modifying a circuit by cutting lines and creating new ones in order to change the electrical function of the circuit. IC planar technologies have an increasing number of metal interconnections making FIB modifications more complex and decreasing their changes of success. The yield of FIB operations on ICs reflects a downward trend that imposes a greater number of circuits to be modified in order to successfully correct a small number of them. This requires extended duration, which is not compatible with production line turn around times. To respond to this problem, two solutions can be defined: either, reducing the duration of each FIB operation or increasing the success rate of FIB modifications. Since reducing the time depends mainly on FIB operator experience, insuring a higher success rate represents a more crucial aspect as both experienced and novice operators could benefit from this improvement. In order to insure successful modifications, it is necessary to control each step of a FIB operation. To do this, we have developed a new method using in situ electrical testing which has a direct impact on the yield of FIB modifications. We will present this innovative development through a real case study of a CMOS ASIC for high-speed communications. Monitoring the electrical behavior at each step in a FIB operation makes it possible to reduce the number of circuits to be modified and consequently reduces system costs thanks to better yield control. Knowing the internal electrical behavior also gives us indications about the impact on reliability of FIB modified circuits. Finally, this approach can be applied to failure analysis and FIB operations on flip chip circuits.

77 FR 29633 - Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL12-68-000] Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC, Alta Wind XIII, LLC, Alta Wind XIV, LLC, Alta Wind XV, LLC, Alta Windpower Development, LLC, TGP Development Company, LLC...

Macroeconomic Consequences of Job Discrimination Against Women in Russia

DTIC Science & Technology

2010-06-01

operator engaged in hot dismantling of resistance furnaces in the production of abrasives 208. Caster of abrasive materials 209. Furnace bottom...are the first fired .125 Additionally, despite more education than their male counterparts, women stay unemployed twice as long as men.126 As a result...and networks (Nos. 204-205) XII. Production of abrasives (Nos. 206-210) XIII. Electrical-engineering production (Nos. 211-219) XIV. Radio

Analysis of Contract Source Selection Strategy

DTIC Science & Technology

2015-07-07

Logistic xiii ACKNOWLEDGMENTS We would like to express our gratitude to our advisors, Professor Rene Rendon and Professor Karen Landale, for their...like to dedicate this project to my beautiful and supportive wife, Amy, and my daughters, Peyton and Claire. Thank you for all your unconditional love...accomplish this milestone due to his unconditional love. I would like to thank my mom, Saraswati, and my dad, Khilendra, for their support and patience

Beyond Consolidation: U.S. Government International Broadcasting in the Post-Cold War Era

DTIC Science & Technology

1994-01-01

vii A c kowledgments .......................................... xiii 1. INTRODUCTION ....................................... 1 2. THE UNITED STATES IN...military power more generally, is diminishing in relevance, paced by the decline of U.S. economic preponderance. The difference between military and...economic power on the one hand, and political and moral authority on the other hand, has been made starkly clear at the beginning of the post-Cold War era

Rapid Training of Information Extraction with Local and Global Data Views

DTIC Science & Technology

2012-05-01

56 xiii 4.1 An example of words and their bit string representations. Bold ones are transliterated Arabic words...Natural Language Processing ( NLP ) community faces new tasks and new domains all the time. Without enough labeled data of a new task or a new domain to...conduct supervised learning, semi-supervised learning is particularly attractive to NLP researchers since it only requires a handful of labeled examples

An Approach to the Management of Hazardous Materials.

DTIC Science & Technology

1981-09-01

fluoride carbon disulfide carbon monoxide hydrochloric acid hydrogen sulfide acetone cyanohydrin phosgene Group XII: Poison B - Meeflaneous a) Gases...b) Liquids sulfur dioxide bromine chlorine boron trifluoride Group XIII: Poison C Group XIV: Poison D Liquid Gas tetraethyl lead fluorine Group XV...with a high and o Nitric acid leaks from a 5,000 gallon storage tank In a growing concentration of electronics industries. Over plant one night and

Application of the Sterility Principle for Tsetse Fly Eradication or Control. Revision.

DTIC Science & Technology

1981-08-14

1977. Digestive processes of haematophagous insects . XIII. Evidence for the digestive function of midgut proleinases in Glossina morsitans morsitans...FOOD AND AGRICULTURAL DEVELOPMENT ABSTRACT This review deals with the conditions required for the successful application of the sterile insect ...numbers of sterile male insects are released into a wild population so that they can disperse and compete with the fertile males of the natural population

Integrated Fusion, Performance Prediction, and Sensor Management for Automatic Target Exploitation

DTIC Science & Technology

2007-05-30

with large region of attraction about the true minimum. The physical optics models provide features for high confidence identification of stationary...the detection test are used to estimate 3D object scattering; multiple images can be noncoherently combined to reconstruct a more complete object...Proc. SPIE Algorithms for Synthetic Aper- ture Radar Imagery XIII, The International Society for Optical Engineering, April 2006. [40] K. Varshney, M. C

Revisiting the mechanism of coagulation factor XIII activation and regulation from a structure/functional perspective

PubMed Central

Gupta, Sneha; Biswas, Arijit; Akhter, Mohammad Suhail; Krettler, Christoph; Reinhart, Christoph; Dodt, Johannes; Reuter, Andreas; Philippou, Helen; Ivaskevicius, Vytautas; Oldenburg, Johannes

2016-01-01

The activation and regulation of coagulation Factor XIII (FXIII) protein has been the subject of active research for the past three decades. Although discrete evidence exists on various aspects of FXIII activation and regulation a combinatorial structure/functional view in this regard is lacking. In this study, we present results of a structure/function study of the functional chain of events for FXIII. Our study shows how subtle chronological submolecular changes within calcium binding sites can bring about the detailed transformation of the zymogenic FXIII to its activated form especially in the context of FXIIIA and FXIIIB subunit interactions. We demonstrate what aspects of FXIII are important for the stabilization (first calcium binding site) of its zymogenic form and the possible modes of deactivation (thrombin mediated secondary cleavage) of the activated form. Our study for the first time provides a structural outlook of the FXIIIA2B2 heterotetramer assembly, its association and dissociation. The FXIIIB subunits regulatory role in the overall process has also been elaborated upon. In summary, this study provides detailed structural insight into the mechanisms of FXIII activation and regulation that can be used as a template for the development of future highly specific therapeutic inhibitors targeting FXIII in pathological conditions like thrombosis. PMID:27453290

The predictive value of markers of fibrinolysis and endothelial dysfunction in the post thrombotic syndrome. A systematic review.

PubMed

Rabinovich, Anat; Cohen, Jacqueline M; Kahn, Susan R

2014-06-01

The post thrombotic syndrome (PTS) develops in 20-40% of deep venous thrombosis (DVT) patients. Risk factors for PTS have not been well elucidated. Identification of risk factors would facilitate individualised risk assessment for PTS. We conducted a systematic review to determine whether biomarkers of fibrinolysis or endothelial dysfunction can predict the risk for PTS among DVT patients. Studies were identified by searching the electronic databases PubMed, EMBASE, Scopus and Web of science. We included studies published between 1990 and 2013, measured biomarker levels in adult DVT patients, and reported rates of PTS development. Fourteen studies were included: 11 investigated the association between D-dimer and PTS; three examined fibrinogen; two measured von Willebrand factor; one measured plasminogen activator inhibitor-1; one assessed ADAMTS-13 (A Disintegrin and Metalloprotease with Thrombospondin type 1 repeats) and one measured factor XIII activity. Studies varied with regards to inclusion criteria, definition of PTS, time point and method of biomarker measurement. We were unable to meta-analyse results due to marked clinical heterogeneity. Descriptively, a significant association with PTS was found for D-dimer in four studies and factor XIII in one study. Further prospective research is needed to elucidate whether these markers might be useful to predict PTS development.

The 1986 Goddard Space Flight Center Battery Workshop

NASA Technical Reports Server (NTRS)

Morrow, George W. (Editor); Yi, Thomas Y. (Editor)

1987-01-01

The subjects covered include: lithium cell technology and safety improvements; nickel-cadmium separator and electrode technology along with associated modifications; flight experience and life testing of nickel-cadmium cell; and nickel-hydrogen applications and technology.

Lensing is low: cosmology, galaxy formation or new physics?

NASA Astrophysics Data System (ADS)

Leauthaud, Alexie; Saito, Shun; Hilbert, Stefan; Barreira, Alexandre; More, Surhud; White, Martin; Alam, Shadab; Behroozi, Peter; Bundy, Kevin; Coupon, Jean; Erben, Thomas; Heymans, Catherine; Hildebrandt, Hendrik; Mandelbaum, Rachel; Miller, Lance; Moraes, Bruno; Pereira, Maria E. S.; Rodríguez-Torres, Sergio A.; Schmidt, Fabian; Shan, Huan-Yuan; Viel, Matteo; Villaescusa-Navarro, Francisco

2017-05-01

We present high signal-to-noise galaxy-galaxy lensing measurements of the Baryon Oscillation Spectroscopic Survey constant mass (CMASS) sample using 250 deg2 of weak-lensing data from Canada-France-Hawaii Telescope Lensing Survey and Canada-France-Hawaii Telescope Stripe 82 Survey. We compare this signal with predictions from mock catalogues trained to match observables including the stellar mass function and the projected and two-dimensional clustering of CMASS. We show that the clustering of CMASS, together with standard models of the galaxy-halo connection, robustly predicts a lensing signal that is 20-40 per cent larger than observed. Detailed tests show that our results are robust to a variety of systematic effects. Lowering the value of S_8=σ _8 \\sqrt{Ω _m/0.3} compared to Planck Collaboration XIII reconciles the lensing with clustering. However, given the scale of our measurement (r < 10 h-1 Mpc), other effects may also be at play and need to be taken into consideration. We explore the impact of baryon physics, assembly bias, massive neutrinos and modifications to general relativity on ΔΣ and show that several of these effects may be non-negligible given the precision of our measurement. Disentangling cosmological effects from the details of the galaxy-halo connection, the effect of baryons, and massive neutrinos, is the next challenge facing joint lensing and clustering analyses. This is especially true in the context of large galaxy samples from Baryon Acoustic Oscillation surveys with precise measurements but complex selection functions.

A general strategy for the ultrafast surface modification of metals

PubMed Central

Shen, Mingli; Zhu, Shenglong; Wang, Fuhui

2016-01-01

Surface modification is an essential step in engineering materials that can withstand the increasingly aggressive environments encountered in various modern energy-conversion systems and chemical processing industries. However, most traditional technologies exhibit disadvantages such as slow diffusion kinetics, processing difficulties or compatibility issues. Here, we present a general strategy for the ultrafast surface modification of metals inspired by electromigration, using aluminizing austenitic stainless steel as an example. Our strategy facilitates the rapid formation of a favourable ductile surface layer composed of FeCrAl or β-FeAl within only 10 min compared with several hours in conventional processes. This result indicates that electromigration can be used to achieve the ultrafast surface modification of metals and can overcome the limitations of traditional technologies. This strategy could be used to aluminize ultra-supercritical steam tubing to withstand aggressive oxidizing environments. PMID:27924909

Tools for phospho- and glycoproteomics of plasma membranes.

PubMed

Wiśniewski, Jacek R

2011-07-01

Analysis of plasma membrane proteins and their posttranslational modifications is considered as important for identification of disease markers and targets for drug treatment. Due to their insolubility in water, studying of plasma membrane proteins using mass spectrometry has been difficult for a long time. Recent technological developments in sample preparation together with important improvements in mass spectrometric analysis have facilitated analysis of these proteins and their posttranslational modifications. Now, large scale proteomic analyses allow identification of thousands of membrane proteins from minute amounts of sample. Optimized protocols for affinity enrichment of phosphorylated and glycosylated peptides have set new dimensions in the depth of characterization of these posttranslational modifications of plasma membrane proteins. Here, I summarize recent advances in proteomic technology for the characterization of the cell surface proteins and their modifications. In the focus are approaches allowing large scale mapping rather than analytical methods suitable for studying individual proteins or non-complex mixtures.

Enzyme Technology of Peroxidases: Immobilization, Chemical and Genetic Modification

NASA Astrophysics Data System (ADS)

Longoria, Adriana; Tinoco, Raunel; Torres, Eduardo

An overview of enzyme technology applied to peroxidases is made. Immobilization on organic, inorganic, and hybrid supports; chemical modification of amino acids and heme group; and genetic modification by site-directed and random mutagenesis are included. Different strategies that were carried out to improve peroxidase performance in terms of stability, selectivity, and catalytic activity are analyzed. Immobilization of peroxidases on inorganic and organic materials enhances the tolerance of peroxidases toward the conditions normally found in many industrial processes, such as the presence of an organic solvent and high temperature. In addition, it is shown that immobilization helps to increase the Total Turnover Number at levels high enough to justify the use of a peroxidase-based biocatalyst in a synthesis process. Chemical modification of peroxidases produces modified enzymes with higher thermostability and wider substrate variability. Finally, through mutagenesis approaches, it is possible to produce modified peroxidases capable of oxidizing nonnatural substrates with high catalytic activity and affinity.

The ethics of molecular memory modification.

PubMed

Hui, Katrina; Fisher, Carl E

2015-07-01

Novel molecular interventions have recently shown the potential to erase, enhance and alter specific long-term memories. Unique features of this form of memory modification call for a close examination of its possible applications. While there have been discussions of the ethics of memory modification in the literature, molecular memory modification (MMM) can provide special insights. Previously raised ethical concerns regarding memory enhancement, such as safety issues, the 'duty to remember', selfhood and personal identity, require re-evaluation in light of MMM. As a technology that exploits the brain's updating processes, MMM helps correct the common misconception that memory is a static entity by demonstrating how memory is plastic and subject to revision even in the absence of external manipulation. Furthermore, while putatively safer than other speculative technologies because of its high specificity, MMM raises notable safety issues, including potential insidious effects on the agent's emotions and personal identity. Nonetheless, MMM possesses characteristics of a more permissible form of modification, not only because it is theoretically safer, but because its unique mechanism of action requires a heightened level of cooperation from the agent. Discussions of memory modification must consider the specific mechanisms of action, which can alter the weight and relevance of various ethical concerns. MMM also highlights the need for conceptual accuracy regarding the term 'enhancement'; this umbrella term will have to be differentiated as new technologies are applied to a widening array of purposes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

The technology for creating of decorative plywood with low formaldehyde emission

NASA Astrophysics Data System (ADS)

Safin, R. R.; Khasanshin, R. R.; Shaikhutdinova, A. R.; Ziatdinov, R. R.

2015-10-01

The development of new technologies of processing of industrial art products to improve their functional, ergonomic and aesthetic properties is one of the important directions of improvement of product design. The article presents the technology of preliminary contact thermal modification of sheets of veneer in the production of low-toxic decorative plywood and laminated products, which lets significantly improve their water resistance. It has been established that thermal modification of wood material causes a decrease in density with increasing temperature and duration of treatment. A mathematical model describing the process of heat treatment of wood veneer and allowing predicting the degree of thermal modification of wood material depending on the modes of modification has been developed. Several studies to determine the basic properties of plywood made on the basis of heat-treated veneer were conducted in the work. Studies have shown that the thermal effect on veneer in the manufacture of plywood provides improves water-repellent properties of it, while not increasing its toxicity. It has also been found that the alternating of layers of wood with varying degrees of heat treatment when creating laminated products greatly enhances the decorative features of the products.

Project CHECO Southeast Asia Report. Fixed Wing Gunships in SEA (Jul 69 - Jul 71)

DTIC Science & Technology

1971-11-30

charac- teristics and components.) AC -ll9Gs were deployed as needed to various bases including Phu Cat , 3mPhan Rang, Da Nang, and Tan Son Nhut, but...270815Z Feb 70 which I cites the performance of RLAF AC -47 crews is on CHECO microfilm reel S-364. Other documents are in the process of being microfilmed...xiii OVERVIEW...................................................... xiv CHAPTER I - AC -47 COMBAT OPERATION

LAUNCH - APOLLO XIII - LUNAR LANDING MISSION - KSC

NASA Image and Video Library

1970-04-11

S70-34855 (11 April 1970) --- The Apollo 13 (Spacecraft 109/Lunar Module 7/Saturn 508) space vehicle is launched from Pad A, Launch Complex 39, Kennedy Space Center (KSC), at 2:13 p.m. (EST), April 11, 1970. The crew of the National Aeronautics and Space Administration's (NASA) third lunar landing mission are astronauts James A., Lovell Jr., commander; John L. Swigert Jr., command module pilot; and Fred W. Haise Jr., lunar module pilot.

A Data-Driven Framework for Rapid Modeling of Wireless Communication Channels

DTIC Science & Technology

2013-12-01

Committee Chair Mathias Kolsch Joel Young Associate Professor of Computer Science Assistant Professor of Computer Science Timothy Chung John J . Leonard...74 xiii Figure 7.8 RSS measurements (relative to S2 buoy) partitioned into 4 groupings anno - tated by the red, green blue and magenta...distribution of this random variable. Suppose it was possible to take additional measurements at other locations (x j | x j 6= xi). In order to do

The Maoist Movement and Its Impact on the Democratic Transition of Nepal

DTIC Science & Technology

2015-03-01

314 Similarly, the Maoists’ popular ban on gambling and alcohol was another prominent campaign. According to Shah, the banning of alcohol garnered...and making our stay meaningful and joyous. xiii THIS PAGE INTENTIONALLY LEFT BLANK xiv I. INTRODUCTION The Maoist insurgency in Nepal had... relationship between “rulers and the ruled” must be smooth.2 So far, Nepalese politics has not achieved this state, even after its most recent transition

Special Operations Liaison Officer: Looking Back to See the Future

DTIC Science & Technology

2014-06-01

Officer GSN global SOF network HQ Headquarters HRC Human Resources Command HRM human resource management xiii IEP International...life away from a U.S. base in a foreign country In May 2013, the USSOCOM International Engagement Program ( IEP ) provided funding to the Naval...manages the USSOCOM IEP . The intent of this study was to produce a formal career path for SOLOs that would eliminate most, if not all, the current

Cyberwar: Are Civilians Back on the Battlefield

DTIC Science & Technology

2015-02-17

long before the Wright brothers finally achieved it in 1903. States, having experienced balloons and anticipating the advent of other forms of...flight, agreed in the 1899 Hague Convention to “prohibit, for a term of five years, the launching of projectiles and explosives from balloons , or by...Princeton, NJ: Princeton University Press, 1976), 87. 8Friedman, The Law of War, xiii. 9 Paul J. Springer, America’s Captives : Treatment of POWs

Military Free Fall Scheduling And Manifest Optimization Model

DTIC Science & Technology

2016-12-01

engines running waiting for the next student load. The annual blade hour cost, which consists of fuel, maintenance, and personnel, is $5.6M for FY-16...tarmac with engines running waiting for the next student load (J. Enke, personal communication, 2016). The annual blade hour cost, which consists of...33 Scenario 2 Nonstandard Run #1 C-27 Two Passes per Lift .......................34 Table 9. xii THIS PAGE INTENTIONALLY LEFT BLANK xiii

Report of the Admission of Women to the U.S. Military Academy (Project Athena III)

DTIC Science & Technology

1979-06-01

Attitudes Toward Women’s Roles. ..... 47 Summary ..... ............ . . . . 52 CHAPTER 2 CADET BASIC TRAINING ........ 54 Male and Female Performances...Sex for West Point Cadets .......... ... 46 17. Comparison of Attitude Toward Wbmen Scores WANS) for Men and Women at Several Institutions...gender. xiii S . . ... , , , , " .... i • :•: - :• Although attitudes toward womens’ roles in society and in the military are more traditional for men

A System Approach to Navy Medical Education and Training. Appendix 5. Neuropsychiatric Technician.

DTIC Science & Technology

1974-08-31

phrased behavioral statements. Through the use of special programs, task inventories are prepared, printouts for special purposes are created following ...the Response Guide (p. xiii) at the perforation, and use the correct side to respond to each task or instrument found on the following white pages...response data. They can be processed and manipulated only by high speed computer capability using rigorously designed specialty programs. In addition to

Countering Al-Shabaab: A Case to Minimize Transnational Terrorist Threats Against Uganda

DTIC Science & Technology

2011-12-01

Region. ...31 xii THIS PAGE INTENTIONALLY LEFT BLANK xiii LIST OF ACRONYMS AND ABBREVIATIONS AMISOM African Union Mission in Somalia ANC African...National Congress AQAP Al-Qaeda in the Arab Peninsula AQI Al-Qaeda in Iraq ARS Alliance for the Re-liberation of Somalia AU African Union COG...Bureau of Investigation GIMF Global Islamic Media Front HOA Horn of Africa ICU Islamic Courts Union ILDMH Ice Link Discotheque in Makindye House

Challenges to Military Operations in Support of U.S. Interests. Volume 2: Main Report

DTIC Science & Technology

2008-12-01

Challenges to Military Operations in Support of U.S. Interests U.S. conventional military capability remains unmatched by any state. As a result, nations...greater importance. PR EF AC E I xiii Preface U.S. conventional military capability remains unmatched by any state. U.S...scope of the study remained robust, presenting the challenge of how to approach the investigation into U.S. capabilities, capability gaps, and

Further Studies in Filmwise Condensation of Steam on Horizontal Finned Tubes

DTIC Science & Technology

1992-03-01

which to base their design of Ocean Thermal Energy Conversion ( OTEC ) heat exchangers . ANL used two shell-and-tube heat exchangers , with no inserts, for...throughout the duration of this study. xiii~q I. INTRODUCTON A. BACKGROUND A reduction in size and weight of all types of heat exchangers aboard Naval...vessels will allow more efficient use of space. The benefits might include greater equipment accessibility for maintenance or greater heat exchanger

Numerical Modeling and Combustion Studies of Scram Jet Simulation

DTIC Science & Technology

2014-12-01

and this work is dedicated to them. xiii Chapter 1 1 Introduction 1.1 Background and Overview Scramjet ( Supersonic Combustion Ramjet) is a type of...engine that op- erates under supersonic airflow conditions. The efficiency in its propulsion system over ramjet has made it a very active research...from the boundary layer of the wall [41]. Moreover, when the crossflow is supersonic , as is the case in the Scramjet configuration, some additional

Lessons From Bosnia: The IFOR Experience

DTIC Science & Technology

1998-01-01

OSD under the direc- tion of ASD (C3I). DoD Command and Control Research Program Assistant Secretary of Defense (C3I) Mr. Anthony Valletta (Acting...Anthony M. Valletta (Acting) Assistant Secretary of Defense C3I xiii Acknowledgments The Honorable Emmett Paige, Jr., Assistant Secretary of Defense... Valletta ; and the Di- rectors J6, the Joint Staff, Admiral Walt Cebrowski, USN, and LTG Doug Buchholz, USA, for their continued interest and support

Relativistic MR–MP Energy Levels for L-shell Ions of Silicon

DOE PAGES

Santana, Juan A.; Lopez-Dauphin, Nahyr A.; Beiersdorfer, Peter

2018-01-15

Level energies are reported for Si v, Si vi, Si vii, Si viii, Si ix, Si x, Si xi, and Si xii. The energies have been calculated with the relativistic Multi-Reference Møller–Plesset Perturbation Theory method and include valence and K-vacancy states with nl up to 5f. The accuracy of the calculated level energies is established by comparison with the recommended data listed in the National Institute of Standards and Technology (NIST) online database. The average deviation of valence level energies ranges from 0.20 eV in Si v to 0.04 eV in Si xii. For K-vacancy states, the available values recommendedmore » in the NIST database are limited to Si xii and Si xiii. The average energy deviation is below 0.3 eV for K-vacancy states. The extensive and accurate data set presented here greatly augments the amount of available reference level energies. Here, we expect our data to ease the line identification of L-shell ions of Si in celestial sources and laboratory-generated plasmas, and to serve as energy references in the absence of more accurate laboratory measurements.« less

Relativistic MR–MP Energy Levels for L-shell Ions of Silicon

NASA Astrophysics Data System (ADS)

Santana, Juan A.; Lopez-Dauphin, Nahyr A.; Beiersdorfer, Peter

2018-01-01

Level energies are reported for Si V, Si VI, Si VII, Si VIII, Si IX, Si X, Si XI, and Si XII. The energies have been calculated with the relativistic Multi-Reference Møller–Plesset Perturbation Theory method and include valence and K-vacancy states with nl up to 5f. The accuracy of the calculated level energies is established by comparison with the recommended data listed in the National Institute of Standards and Technology (NIST) online database. The average deviation of valence level energies ranges from 0.20 eV in Si V to 0.04 eV in Si XII. For K-vacancy states, the available values recommended in the NIST database are limited to Si XII and Si XIII. The average energy deviation is below 0.3 eV for K-vacancy states. The extensive and accurate data set presented here greatly augments the amount of available reference level energies. We expect our data to ease the line identification of L-shell ions of Si in celestial sources and laboratory-generated plasmas, and to serve as energy references in the absence of more accurate laboratory measurements.

VizieR Online Data Catalog: Relativistic MR-MP energy levels for Si (Santana+, 2018)

NASA Astrophysics Data System (ADS)

Santana, J. A.; Lopez-Dauphin, N. A.; Beiersdorfer, P.

2018-03-01

Level energies are reported for Si V, Si VI, Si VII, Si VIII, Si IX, Si X, Si XI, and Si XII. The energies have been calculated with the relativistic Multi- Reference Moller-Plesset Perturbation Theory method and include valence and K-vacancy states with nl up to 5f. The accuracy of the calculated level energies is established by comparison with the recommended data listed in the National Institute of Standards and Technology (NIST) online database. The average deviation of valence level energies ranges from 0.20eV in SiV to 0.04eV in SiXII. For K-vacancy states, the available values recommended in the NIST database are limited to Si XII and Si XIII. The average energy deviation is below 0.3eV for K-vacancy states. The extensive and accurate data set presented here greatly augments the amount of available reference level energies. We expect our data to ease the line identification of L-shell ions of Si in celestial sources and laboratory-generated plasmas, and to serve as energy references in the absence of more accurate laboratory measurements. (1 data file).

Relativistic MR–MP Energy Levels for L-shell Ions of Silicon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Santana, Juan A.; Lopez-Dauphin, Nahyr A.; Beiersdorfer, Peter

Level energies are reported for Si v, Si vi, Si vii, Si viii, Si ix, Si x, Si xi, and Si xii. The energies have been calculated with the relativistic Multi-Reference Møller–Plesset Perturbation Theory method and include valence and K-vacancy states with nl up to 5f. The accuracy of the calculated level energies is established by comparison with the recommended data listed in the National Institute of Standards and Technology (NIST) online database. The average deviation of valence level energies ranges from 0.20 eV in Si v to 0.04 eV in Si xii. For K-vacancy states, the available values recommendedmore » in the NIST database are limited to Si xii and Si xiii. The average energy deviation is below 0.3 eV for K-vacancy states. The extensive and accurate data set presented here greatly augments the amount of available reference level energies. Here, we expect our data to ease the line identification of L-shell ions of Si in celestial sources and laboratory-generated plasmas, and to serve as energy references in the absence of more accurate laboratory measurements.« less

Survey of Enabling Technologies for CAPS

NASA Technical Reports Server (NTRS)

Antol, Jeffrey; Mazanek, Daniel D.; Koons, Robert H.

2005-01-01

The enabling technologies required for the development of a viable Comet/Asteroid Protection System (CAPS) can be divided into two principal areas: detection and deflection/orbit modification. With the proper funding levels, many of the technologies needed to support a CAPS architecture could be achievable within the next 15 to 20 years. In fact, many advanced detection technologies are currently in development for future in-space telescope systems such as the James Webb Space Telescope (JWST), formerly known as the Next Generation Space Telescope. It is anticipated that many of the JWST technologies would be available for application for CAPS detection concepts. Deflection/orbit modification technologies are also currently being studied as part of advanced power and propulsion research. However, many of these technologies, such as extremely high-output power systems, advanced propulsion, heat rejection, and directed energy systems, would likely be farther term in availability than many of the detection technologies. Discussed subsequently is a preliminary examination of the main technologies that have been identified as being essential to providing the element functionality defined during the CAPS conceptual study. The detailed requirements for many of the technology areas are still unknown, and many additional technologies will be identified as future in-depth studies are conducted in this area.

Laser modification of macroscopic properties of metal surface layer

NASA Astrophysics Data System (ADS)

Kostrubiec, Franciszek

1995-03-01

Surface laser treatment of metals comprises a number of diversified technological operations out of which the following can be considered the most common: oxidation and rendering surfaces amorphous, surface hardening of steel, modification of selected physical properties of metal surface layers. In the paper basic results of laser treatment of a group of metals used as base materials for electric contacts have been presented. The aim of the study was to test the usability of laser treatment from the viewpoint of requirements imposed on materials for electric contacts. The results presented in the paper refer to two different surface treatment technologies: (1) modification of infusible metal surface layer: tungsten and molybdenum through laser fusing of their surface layer and its crystallization, and (2) modification of surface layer properties of other metals through laser doping of their surface layer with foreign elements. In the paper a number of results of experimental investigations obtained by the team under the author's supervision are presented.

Nanoscale Surface Modifications of Orthopaedic Implants: State of the Art and Perspectives

PubMed Central

Staruch, RMT; Griffin, MF; Butler, PEM

2016-01-01

Background: Orthopaedic implants such as the total hip or total knee replacement are examples of surgical interventions with postoperative success rates of over 90% at 10 years. Implant failure is associated with wear particles and pain that requires surgical revision. Improving the implant - bone surface interface is a key area for biomaterial research for future clinical applications. Current implants utilise mechanical, chemical or physical methods for surface modification. Methods: A review of all literature concerning the nanoscale surface modification of orthopaedic implant technology was conducted. Results: The techniques and fabrication methods of nanoscale surface modifications are discussed in detail, including benefits and potential pitfalls. Future directions for nanoscale surface technology are explored. Conclusion: Future understanding of the role of mechanical cues and protein adsorption will enable greater flexibility in surface control. The aim of this review is to investigate and summarise the current concepts and future directions for controlling the implant nanosurface to improve interactions. PMID:28217214

Relation of Astronomy to other Sciences, Culture and Society

NASA Astrophysics Data System (ADS)

Harutyunian, H. A.; Mickaelian, A. M.; Farmanyan, S. V.

2015-07-01

The book contains the Proceedings of XIII Annual Meeting of the Armenian Astronomical Society "Relation of Astronomy to other Sciences, Culture and Society". It consists of 9 main sections: "Introductory", "Astronomy and Philosophy", "Astrobiology", "Space-Earth Connections", "Astrostatistics and Astroinformatics", "Astronomy and Culture, Astrolinguistics", "Archaeoastronomy", "Scientific Tourism and Scientific Journalism", and "Armenian Astronomy". The book may be interesting to astronomers, philosophers, biologists, culturologists, linguists, historians, archaeologists and to other specialists, as well as to students.

Wellness at Air Command and Staff College: Impacting Total Force Readiness Through Tomorrow’s Leaders

DTIC Science & Technology

1998-04-01

Joseph P. Opatz, ed. [Association for Worksite Health Promotion], Economic Impact of Worksite Health Promotion (Champaign, IL: Human Kinetics Publishers...Employee Health Promotion Programs (Champaign, IL: Human Kinetics Publishers, 1992), viii. 23 Erfurt, et al., 272. 24 O’Donnell and Harris, xiii. 25 Ibid...Champaign, IL: Human Kinetics Publishers, 1992), viii-ix. 40 Glossary ACSC Air Command and Staff College AU Air University AWC Air War College AY Academic

The need for a regional framework for marine scientific research in the Black Sea and Mediterranean Sea.

PubMed

Oral, Nilufer

2014-10-01

One of the important contributions of the 1982 United Nations Law of the Sea Convention (UNCLOS) is Part XIII on Marine Scientific Research (MSR). UNCLOS recognizes the general rule that all states have the right to conduct MSR subject to rights and duties of other states under the convention and in addition, the obligation to promote and facilitate MSR. Copyright © 2014 Elsevier B.V. All rights reserved.

Department of Defense Small Business (SB) Program: A Knowledge-Level Analysis of How Customer Education Relates to Meeting SB Goals

DTIC Science & Technology

2014-12-01

xiii SB small business SBA Small Business Administration SBP small business program SBS small business specialist SDB small disadvantaged business...government contracts. 2. Small Disadvantaged Business The purpose of the Small Disadvantaged Business ( SDB ) program is to increase opportunities for...socially and economically disadvantaged businesses to compete for contract awards. A SDB is “a small business that is at least 51 percent owned by one

An Adaptive, Multi-Rate Linear Quadratic Regulator for a Shipboard MVDC Distribution System with Constant Power Loads

DTIC Science & Technology

2017-09-01

12. xii THIS PAGE INTENTIONALLY LEFT BLANK xiii LIST OF ACRONYMS AND ABBREVIATIONS AC alternating current ATG auxiliary turbine generator...invariant MTG main turbine generator MVDC medium voltage DC NAVSEA U.S. Naval Sea Systems Command PGM power generation module RC resistor-capacitor RL...arrangement because the gas turbines used for prime movers are more efficient when they are fully loaded. By amalgamating loads onto fewer machines

Basics of Physical Modeling in Coastal and Hydraulic Engineering

DTIC Science & Technology

2013-09-01

gravity (Fg), viscosity (Fv), surface tension (Fs), and elasticity (Fe) must have the same ratios. This requirement arises from Newton’s Second Law which...they are relatively small. Viscosity can be neglected in most free-surface models if the model is not too (a) (b) ERDC/CHL CHETN-XIII-3 September... viscosity is to ensure that the model flow is in the turbulent range, which occurs for Re above approximately 104. The Reynolds number (Re) is defined

Utilization of Concurrent Buffers to Facilitate Seamless Data Transition in Tactical Cellular Communications

DTIC Science & Technology

2015-09-01

INTENTIONALLY LEFT BLANK xiii LIST OF ACRONYMS AND ABBREVIATIONS 2G 2nd Generation 3G 3rd Generation 3GPP 3rd Generation Partnership Project 4G 4th...System (UMTS) is the standard that governs 3rd Generation ( 3G ) migration of Global Services for Mobile (GSM) networks. It defines packet-based...network may assist or mitigate. 14. SUBJECT TERMS IEEE, 802.21, Media Independent Handover, mobile , communications, cyber, tactical, buffer, cellular

Developing Evaluation Measures for the Second Stage Next Generation Engine on Evolved Expendable Launch Vehicles

DTIC Science & Technology

2012-03-01

xii THIS PAGE INTENTIONALLY LEFT BLANK xiii LIST OF ACRONYMS AND ABBREVIATIONS CDR Critical Design Review DCSS Delta Cryogenic Second Stage...seen below in Figure 5, include the Common Booster Core powered by a Pratt and Whitney Rocketdyne RS-68 engine, a Delta Cryogenic Second Stage (DCSS...do have one significant similarity. The Centaur of the Atlas V and Delta IV Cryogenic Second Stage, both use variants of the Pratt and Whitney

Biomimetic Delivery of Keratinocyte Growth Factor upon Cellular Demand for Accelerated Wound Healing in Vitro and in Vivo

PubMed Central

Geer, David J.; Swartz, Daniel D.; Andreadis, Stelios T.

2005-01-01

Exogenous keratinocyte growth factor (KGF) significantly enhances wound healing, but its use is hampered by a short biological half-life and lack of tissue selectivity. We used a biomimetic approach to achieve cell-controlled delivery of KGF by covalently attaching a fluorescent matrix-binding peptide that contained two domains: one recognized by factor XIII and the other by plasmin. Modified KGF was incorporated into the fibrin matrix at high concentration in a factor XIII-dependent manner. Cell-mediated activation of plasminogen to plasmin degraded the fibrin matrix and cleaved the peptides, releasing active KGF to the local microenvironment and enhancing epithelial cell proliferation and migration. To demonstrate in vivo effectiveness, we used a hybrid model of wound healing that involved transplanting human bioengineered skin onto athymic mice. At 6 weeks after grafting, the transplanted tissues underwent full thickness wounding and treatment with fibrin gels containing bound KGF. In contrast to topical KGF, fibrin-bound KGF persisted in the wounds for several days and was released gradually, resulting in significantly enhanced wound closure. A fibrinolytic inhibitor prevented this healing, indicating the requirement for cell-mediated fibrin degradation to release KGF. In conclusion, this biomimetic approach of localized, cell-controlled delivery of growth factors may accelerate healing of large full-thickness wounds and chronic wounds that are notoriously difficult to heal. PMID:16314471

The Non-catalytic B Subunit of Coagulation Factor XIII Accelerates Fibrin Cross-linking*

PubMed Central

Souri, Masayoshi; Osaki, Tsukasa; Ichinose, Akitada

2015-01-01

Covalent cross-linking of fibrin chains is required for stable blood clot formation, which is catalyzed by coagulation factor XIII (FXIII), a proenzyme of plasma transglutaminase consisting of catalytic A (FXIII-A) and non-catalytic B subunits (FXIII-B). Herein, we demonstrate that FXIII-B accelerates fibrin cross-linking. Depletion of FXIII-B from normal plasma supplemented with a physiological level of recombinant FXIII-A resulted in delayed fibrin cross-linking, reduced incorporation of FXIII-A into fibrin clots, and impaired activation peptide cleavage by thrombin; the addition of recombinant FXIII-B restored normal fibrin cross-linking, FXIII-A incorporation into fibrin clots, and activation peptide cleavage by thrombin. Immunoprecipitation with an anti-fibrinogen antibody revealed an interaction between the FXIII heterotetramer and fibrinogen mediated by FXIII-B and not FXIII-A. FXIII-B probably binds the γ-chain of fibrinogen with its D-domain, which is near the fibrin polymerization pockets, and dissociates from fibrin during or after cross-linking between γ-chains. Thus, FXIII-B plays important roles in the formation of a ternary complex between proenzyme FXIII, prosubstrate fibrinogen, and activator thrombin. Accordingly, congenital or acquired FXIII-B deficiency may result in increased bleeding tendency through impaired fibrin stabilization due to decreased FXIII-A activation by thrombin and secondary FXIII-A deficiency arising from enhanced circulatory clearance. PMID:25809477

Enhanced lysis and accelerated establishment of viscoelastic properties of fibrin clots are associated with pulmonary embolism.

PubMed

Martinez, Marissa R; Cuker, Adam; Mills, Angela M; Crichlow, Amanda; Lightfoot, Richard T; Chernysh, Irina N; Nagaswami, Chandrasekaran; Weisel, John W; Ischiropoulos, Harry

2014-03-01

The factors that contribute to pulmonary embolism (PE), a potentially fatal complication of deep vein thrombosis (DVT), remain poorly understood. Whereas fibrin clot structure and functional properties have been implicated in the pathology of venous thromboembolism and the risk for cardiovascular complications, their significance in PE remains uncertain. Therefore, we systematically compared and quantified clot formation and lysis time, plasminogen levels, viscoelastic properties, activated factor XIII cross-linking, and fibrin clot structure in isolated DVT and PE subjects. Clots made from plasma of PE subjects showed faster clot lysis times with no differences in lag time, rate of clot formation, or maximum absorbance of turbidity compared with DVT. Differences in lysis times were not due to alterations in plasminogen levels. Compared with DVT, clots derived from PE subjects showed accelerated establishment of viscoelastic properties, documented by a decrease in lag time and an increase in the rate of viscoelastic property formation. The rate and extent of fibrin cross-linking by activated factor XIII were similar between clots from DVT and PE subjects. Electron microscopy revealed that plasma fibrin clots from PE subjects exhibited lower fiber density compared with those from DVT subjects. These data suggest that clot structure and functional properties differ between DVT and PE subjects and provide insights into mechanisms that may regulate embolization.

Enhanced lysis and accelerated establishment of viscoelastic properties of fibrin clots are associated with pulmonary embolism

PubMed Central

Martinez, Marissa R.; Cuker, Adam; Mills, Angela M.; Crichlow, Amanda; Lightfoot, Richard T.; Chernysh, Irina N.; Nagaswami, Chandrasekaran; Weisel, John W.

2014-01-01

The factors that contribute to pulmonary embolism (PE), a potentially fatal complication of deep vein thrombosis (DVT), remain poorly understood. Whereas fibrin clot structure and functional properties have been implicated in the pathology of venous thromboembolism and the risk for cardiovascular complications, their significance in PE remains uncertain. Therefore, we systematically compared and quantified clot formation and lysis time, plasminogen levels, viscoelastic properties, activated factor XIII cross-linking, and fibrin clot structure in isolated DVT and PE subjects. Clots made from plasma of PE subjects showed faster clot lysis times with no differences in lag time, rate of clot formation, or maximum absorbance of turbidity compared with DVT. Differences in lysis times were not due to alterations in plasminogen levels. Compared with DVT, clots derived from PE subjects showed accelerated establishment of viscoelastic properties, documented by a decrease in lag time and an increase in the rate of viscoelastic property formation. The rate and extent of fibrin cross-linking by activated factor XIII were similar between clots from DVT and PE subjects. Electron microscopy revealed that plasma fibrin clots from PE subjects exhibited lower fiber density compared with those from DVT subjects. These data suggest that clot structure and functional properties differ between DVT and PE subjects and provide insights into mechanisms that may regulate embolization. PMID:24414255

Evaluating Factor XIII Specificity for Glutamine-Containing Substrates Using a MALDI-TOF Mass Spectrometry Assay

PubMed Central

Doiphode, Prakash G.; Malovichko, Marina V.; Mouapi, Kelly Njine; Maurer, Muriel C.

2014-01-01

Activated Factor XIII (FXIIIa) catalyzes the formation of γ-glutamyl-ε-lysyl cross-links within the fibrin blood clot network. Although several cross-linking targets have been identified, the characteristic features that define FXIIIa substrate specificity are not well understood. To learn more about how FXIIIa selects its targets, a matrix-assisted laser desorption ionization – time of flight mass spectrometry (MALDI-TOF MS) based assay was developed that could directly follow the consumption of a glutamine-containing substrate and the formation of a cross-linked product with glycine ethylester. This FXIIIa kinetics assay is no longer reliant on a secondary coupled reaction, on substrate labeling, or on detecting the final deacylation portion of the transglutaminase reaction. With the MALDI-TOF MS assay, glutamine-containing peptides derived from α2-antiplasmin, S. Aureus fibronectin binding protein A, and thrombin activatable fibrinolysis inhibitor were examined directly. Results suggest that the FXIIIa active site surface responds to changes in substrate residues following the reactive glutamine. The P-1 substrate position is sensitive to charge character and the P-2 and P-3 to the broad FXIIIa substrate specificity pockets. The more distant P-8 to P-11 region serves as a secondary substrate anchoring point. New knowledge on FXIIIa specificity may be used to design better substrates or inhibitors of this transglutaminase. PMID:24751466

Local activation of coagulation factor XIII reduces systemic complications and improves the survival of mice after Streptococcus pyogenes M1 skin infection.

PubMed

Deicke, Christin; Chakrakodi, Bhavya; Pils, Marina C; Dickneite, Gerhard; Johansson, Linda; Medina, Eva; Loof, Torsten G

2016-11-01

Coagulation is a mechanism for wound healing after injury. Several recent studies delineate an additional role of the intrinsic pathway of coagulation, also known as the contact system, in the early innate immune response against bacterial infections. In this study, we investigated the role of factor XIII (FXIII), which is activated upon coagulation induction, during Streptococcus pyogenes-mediated skin and soft tissue infections. FXIII has previously been shown to be responsible for the immobilization of bacteria within a fibrin network which may prevent systemic bacterial dissemination. In order to investigate if the FXIII-mediated entrapment of S. pyogenes also influences the disease outcome we used a murine S. pyogenes M1 skin and soft tissue infection model. Here, we demonstrate that a lack of FXIII leads to prolonged clotting times, increased signs of inflammation, and elevated bacterial dissemination. Moreover, FXIII-deficient mice show an impaired survival when compared with wildtype animals. Additionally, local reconstitution of FXIII-deficient mice with a human FXIII-concentrate (Fibrogammin ® P) could reduce the systemic complications, suggesting a protective role for FXIII during early S. pyogenes skin infection. FXIII therefore might be a possible therapeutically application to support the early innate immune response during skin infections caused by S. pyogenes. Copyright © 2016 Elsevier GmbH. All rights reserved.

Functional factor XIII-A is exposed on the stimulated platelet surface

PubMed Central

Mitchell, Joanne L.; Lionikiene, Ausra S.; Fraser, Steven R.; Whyte, Claire S.; Booth, Nuala A.

2014-01-01

Factor XIII (FXIII) stabilizes thrombi against fibrinolysis by cross-linking α2-antiplasmin (α2AP) to fibrin. Cellular FXIII (FXIII-A) is abundant in platelets, but the extracellular functions of this pool are unclear because it is not released by classical secretion mechanisms. We examined the function of platelet FXIII-A using Chandler model thrombi formed from FXIII-depleted plasma. Platelets stabilized FXIII-depleted thrombi in a transglutaminase-dependent manner. FXIII-A activity on activated platelets was unstable and was rapidly lost over 1 hour. Inhibiting platelet activation abrogated the ability of platelets to stabilize thrombi. Incorporating a neutralizing antibody to α2AP into FXIII-depleted thrombi revealed that the stabilizing effect of platelet FXIII-A on lysis was α2AP dependent. Platelet FXIII-A activity and antigen were associated with the cytoplasm and membrane fraction of unstimulated platelets, and these fractions were functional in stabilizing FXIII-depleted thrombi against lysis. Fluorescence confocal microscopy and flow cytometry revealed exposure of FXIII-A on activated membranes, with maximal signal detected with thrombin and collagen stimulation. FXIII-A was evident in protruding caps on the surface of phosphatidylserine-positive platelets. Our data show a functional role for platelet FXIII-A through exposure on the activated platelet membrane where it exerts antifibrinolytic function by cross-linking α2AP to fibrin. PMID:25331118

Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit.

PubMed

Lauer, Peter; Metzner, Hubert J; Zettlmeissl, Gerd; Li, Meng; Smith, Austin G; Lathe, Richard; Dickneite, Gerhard

2002-12-01

Blood coagulation factor XIII (FXIII) promotes cross-linking of fibrin during blood coagulation; impaired clot stabilization in human genetic deficiency is associated with marked pathologies of major clinical impact, including bleeding symptoms and deficient wound healing. To investigate the role of FXIII we employed homologous recombination to generate a targeted deletion of the inferred exon 7 of the FXIII-A gene. FXIII transglutaminase activity in plasma was reduced to about 50% in mice heterozygous for the mutant allele, and was abolished in homozygous null mice. Plasma fibrin gamma-dimerization was also indetectable in the homozygous deficient animals, confirming the absence of activatable FXIII. Homozygous mutant mice were fertile, although reproduction was impaired. Bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage in mutant mice were associated with reduced survival. Arrest of tail-tip bleeding in FXIII-A deficient mice was markedly and significantly delayed; replacement of mutant mice with human plasma FXIII (Fibrogammin P) restored bleeding time to within the normal range. Thrombelastography (TEG) experiments demonstrated impaired clot stabilization in FXIII-A mutant mice, replacement with human FXIII led to dose-dependent TEG normalization. The mutant mice thus reiterate some key features of the human genetic disorder: they will be valuable in assessing the role of FXIII in other associated pathologies and the development of new therapies.

Stability of Beriplast P fibrin sealant: storage and reconstitution.

PubMed

Eberhard, Ulrich; Broder, Martin; Witzke, Günther

2006-04-26

This study was performed to investigate the stability of Beriplast P fibrin sealant (FS) across a range of storage conditions, both pre- and post-reconstitution. Storage stability of the FS was evaluated during long-term refrigeration (24 months) with or without interim storage at elevated temperatures (40 degrees C for 1 week and 25 degrees C for 1 and 3 months). Stability of individual FS components was assessed by measuring: fibrinogen content, Factor XIII activity (FXIII), thrombin activity and aprotinin potency. The package integrity of each component was also checked (sterility testing, moisture content and pH). Storage stability was also evaluated by testing the reconstituted product for adhesion (tearing force testing after mixing the solutions) and sterility. Reconstitution stability was evaluated following 3-months' storage, for up to 50 h post-reconstitution using the same tests as for the storage stability investigations. Pre-defined specifications were met for fibrinogen content, Factor XIII activity, and thrombin activity, demonstrating storage stability. Package integrity and the functionality and sterility of the reconstituted product were confirmed throughout. Reconstitution stability was demonstrated for up to 50 h following reconstitution, in terms of both tearing force and sterility tests. In conclusion, the storage stability of Beriplast P was demonstrated over a range of 24-month storage schedules including interim exposure to elevated temperature, and the reconstituted product was stable for up to 50 h.

Fatigue characteristics of SAE52100 steel via ultrasonic nanocrystal surface modification technology.

PubMed

Pyun, Young Sik; Suh, Chang Min; Yamaguchi, Tokutaro; Im, Jong Soon; Kim, Jun Hyong; Amanov, Auezhan; Park, Jeong Hyeon

2012-07-01

Ultrasonic nanocrystal surface modification (UNSM) technology is a novel surface modification technology that can improve the mechanical and tribological properties of interacting surfaces in relative motion. UNSM treatment was utilized to improve the wear resistance fatigue strength of slim bearing rings made of SAE52100 bearing steel without damaging the raceway surfaces. In this study, wear and fatigue results that were subjected to different impact loads of the UNSM treatment were investigated and compared with those of the untreated specimen. The microhardness of the UNSM-treated specimens increased by about 20%, higher than that of the untreated specimens. The X-ray diffraction analysis showed that a compressive residual stress of more than 1,000 MPa was induced after the UNSM treatment. Also, electron backscatter diffraction analysis was used to study the surface structure and nanograin refinement. The results showed that the rolling contact fatigue life and the rotary bending fatigue strength of the UNSM-treated specimens increased by about 80% and 31%, respectively, compared to those of the untreated specimen. These results might be attributed to the increased microhardness, the induced compressive residual stress, and the nanocrystal structure modification after the UNSM treatment. In addition, the fracture surface analysis showed that the fish eye crack initiation phenomenon was observed after the UNSM treatment.

Enhancing the functional properties of thermophilic enzymes by chemical modification and immobilization.

PubMed

Cowan, Don A; Fernandez-Lafuente, Roberto

2011-09-10

The immobilization of proteins (mostly typically enzymes) onto solid supports is mature technology and has been used successfully to enhance biocatalytic processes in a wide range of industrial applications. However, continued developments in immobilization technology have led to more sophisticated and specialized applications of the process. A combination of targeted chemistries, for both the support and the protein, sometimes in combination with additional chemical and/or genetic engineering, has led to the development of methods for the modification of protein functional properties, for enhancing protein stability and for the recovery of specific proteins from complex mixtures. In particular, the development of effective methods for immobilizing large multi-subunit proteins with multiple covalent linkages (multi-point immobilization) has been effective in stabilizing proteins where subunit dissociation is the initial step in enzyme inactivation. In some instances, multiple benefits are achievable in a single process. Here we comprehensively review the literature pertaining to immobilization and chemical modification of different enzyme classes from thermophiles, with emphasis on the chemistries involved and their implications for modification of the enzyme functional properties. We also highlight the potential for synergies in the combined use of immobilization and other chemical modifications. Copyright © 2011 Elsevier Inc. All rights reserved.

[CRISPR-Cas9, a new chance for somatic gene therapy].

PubMed

Jordan, Bertrand

2015-11-01

Targeted modification of genes ("gene editing") is made much easier by the recently developed CRISPR-Cas9 system. This has raised alarm about possible uses of this technology for germline modification of the human genome; however this technology has less controversial applications, notably for somatic gene therapy with already some striking demonstrations in animal systems. Because of its precision and relative ease of use, CRISPR can be expected to drive a revolution in gene therapy and to turn it into a more mainstream approach. © 2015 médecine/sciences – Inserm.

Utilization of TALEN and CRISPR/Cas9 technologies for gene targeting and modification

PubMed Central

Pu, Jiali; Zhang, Baorong; Feng, Jian

2015-01-01

The capability to modify the genome precisely and efficiently offers an extremely useful tool for biomedical research. Recent developments in genome editing technologies such as transcription activator-like effector nuclease and the clustered regularly interspaced short palindromic repeats system have made genome modification available for a number of organisms with relative ease. Here, we introduce these genome editing techniques, compare and contrast each technical approach and discuss their potential to study the underlying mechanisms of human disease using patient-derived induced pluripotent stem cells. PMID:25956682

NREL Researchers Test Solar Thermal Technology

Science.gov Websites

and manufacturing modifications that could lead to significant cost reductions. The major modifications include a larger reflective area (170 square meters) and a low-cost mirror facet design in which this program. SAIC's low cost stretched-membrane heliostat represents a significant advancement in

36 CFR 294.27 - Corrections and modifications.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Corrections and modifications. 294.27 Section 294.27 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE..., or improvements in mapping technology. The Chief may issue administrative corrections after a 30-day...

Positive Inclusion Experiences.

ERIC Educational Resources Information Center

Ensign, Arselia, Ed.

1996-01-01

This guide focuses on the use of low-end technology to make education more inclusive for children and adolescents with disabilities. The definition of "assistive technology" is discussed, and low-end technology is defined as simple modification/adaptation of toys and games, design and construction of simple switching devices, and the…

40 CFR 430.24 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2012 CFR

2012-07-01

... new technology components or process modifications and identifying critical path relationships within... degree of effluent reduction attainable by the application of best available technology economically... effluent reduction attainable by the application of best available technology economically achievable (BAT...

KSC-05pd2530

NASA Image and Video Library

2005-11-30

KENNEDY SPACE CENTER, FLA. - In Orbiter Processing Facility Bay 2, the nose cap of space shuttle Endeavour is prepared for installation of thermal protection system blankets. Endeavour recently came out of a nearly two-year Orbiter Major Modification period which began in December 2003. Engineers and technicians spent 900,000 hours performing 124 modifications to the vehicle. These included all recommended return-to-flight safety modifications, bonding more than 1,000 thermal protection system tiles and inspecting more than 150 miles of wiring throughout the orbiter. Shuttle major modification periods are scheduled at regular intervals to enhance safety and performance, infuse new technology, and allow for thorough inspections of the airframe and wiring of the vehicles. This was the second of these modification periods performed entirely at Kennedy Space Center. Endeavour's previous modification was completed in March 1997.

Proposal of Modification Strategy of NC Program in the Virtual Manufacturing Environment

NASA Astrophysics Data System (ADS)

Narita, Hirohisa; Chen, Lian-Yi; Fujimoto, Hideo; Shirase, Keiichi; Arai, Eiji

Virtual manufacturing will be a key technology in process planning, because there are no evaluation tools for cutting conditions. Therefore, virtual machining simulator (VMSim), which can predict end milling processes, has been developed. The modification strategy of NC program using VMSim is proposed in this paper.

Examining the Teaching of Science, and Technology and Engineering Content and Practices: An Instrument Modification Study

ERIC Educational Resources Information Center

Love, Tyler S.; Wells, John G.; Parkes, Kelly A.

2017-01-01

A modified Reformed Teaching Observation Protocol (RTOP) (Piburn & Sawada, 2000) instrument was used to separately examine eight technology and engineering (T&E) educators' teaching of science, and T&E content and practices, as called for by the "Standards for Technological Literacy: Content for the Study of Technology"…

Balancing Work Responsibilities and Family Needs: The Federal Civil Service Response

DTIC Science & Technology

1991-11-01

Since better part-time benefits package than some other our analysis unco’ ered no substantive drawbacks employers . Federal part-timers are typically...Government can improve its status as a/model employer in the work and family benefits area. ( o/ I hope you will find this report useful as you develop plans...Xiii OVERVIEW "Cafeteria" Benefits : Conclusions: The Government does not offer a "cafeteria" As an employer , the Federal Government has a benefits

The Role of p53 Mutations in Metastasis of Prostate Cancer to Bone

DTIC Science & Technology

2004-12-01

described in Methods xiii. We have shown that the addition of ascorbic acid to MC3T3-El cultures results in increased matrix mineralization (Appendix...suggested that we inject the mice with calcein at 9 days and 2 days prior to euthanasia: as calcein fluoresces following binding to calcium in the bone... calcium deposits: silver lactate staining increases sensitivity and reduces background. Histochem. J., 25, 446-251 (1993) B. A. Scheven, J. S. Milne and

Fundamentals of Fatigue and Fracture Mechanics

DTIC Science & Technology

1988-10-01

1987). 5. R.V. Pieri and G.B. Sinclair, "On scaling and the Paris law for fatigue crack growth," Proceedings of SECTAM XIII, Columbia, South Carolina...Vol. 1, pp. 372-376 (1986). 6. G.B. Sinclair and R.V. Pieri , "On obtaining fatigue crack growth parameters from the literature," to be submitted to...theliterature: a fairly extensive recent bibliography[2] cites some 101 related references while more recent extensions to [2] by Pieri [3] provide a further 36

Proceedings of the Annual U.S. Army Operations Research Symposium (13th) , AORS XIII, Held at Fort Lee, Virginia on 29 October - 1 November 1974, Co- Hosted by Army Logistics Center, Fort Lee, Virginia and Army Quartermaster Center and Fort Lee, Virginia. Volume 2

DTIC Science & Technology

1974-11-01

Directorate, Rock Island, Illinois. 538 TITLE: Significant Difference Technique AUTHOR: Mr. Robert P. Lewis, Jr. US Army Logistics Management Center...was first used in a Decision Risk Analysis in August, 1971, at the Army Logistics Management Center, by John Cocker- ham and Harold Stafford. There is

[Secret drug tribulations and French legislation].

PubMed

Charlot, Colette

2002-01-01

From an official Montpellier prefecture paper of 18th century, we are interested in a secret drug from Provence origin: the Irroë powder. This purgative will pass from "secret" drug status to "patent" drug. It's notoriety will come from its arrival to Paris. The law of 21th germinal year XI, the decret of 25 prairial year XIII and this of 18th 1810 imposed to give the drug composition to an official status; that examined and permit it's sale. This secret will be produce for half century.

How Suspicion Grows: Effects of Population Size on Cooperation

DTIC Science & Technology

2014-09-01

suspicious tit-for-tat TFT tit-for-tat TF2T tit-for-two-tats xiii THIS PAGE INTENTIONALLY LEFT BLANK xiv Executive Summary People in a group typically...theoretic model mathematically tractable, we restrict each individual to four strategies: tit-for-two-tats (TF2T), tit-for-tat ( TFT ), suspicious-tit...stranger, TF2T will begin by cooperation twice, TFT by cooperating once, and STFT by defecting once. After the initial moves, in each encounter, the

The Military’s Role in Counterterrorism: Examples and Implications for Liberal Democracies (The Letort Papers)

DTIC Science & Technology

2011-05-01

or any other UK government agency, the U.S. Department of the Army, the U.S. Department of Defense, or the U.S. Government . Authors of Strategic...the post-2001 “War on Terror” and the criticisms expressed by foreign governments , mem- bers of Congress, human rights activists, journalists, and...by Sussex Academic Press in 2012. xiii SUMMARY In the aftermath of the September 11, 2001 (9/11) attacks, the U.S. Government was criticized for

Ground-based observations of the corona in the visible and NIR spectral ranges

NASA Technical Reports Server (NTRS)

Epple, Alexander; Schwenn, Rainer

1995-01-01

Since late 1993 we have been using a mirror coronagraph on Pic du Midi (PICO) to observe the solar emission corona in several spectral lines of (FE-X), (FE-XIII), and (FE-XIV). For good meteorological conditions the diffuse corona and coronal holes in between can be seen out to 1.2 solar mass for sun center. Active regions can be mapped to bond 1.5 solar mass in the green and infrared lines. Recent observations of PICO are presented.

Refrigeration Showcases

NASA Technical Reports Server (NTRS)

1997-01-01

Through the Technology Affiliates Program at the Jet Propulsion Laboratory (JPL), valuable modifications were made to refrigerator displays built by Displaymor Manufacturing Company, Inc. By working with JPL, Displaymor could address stiffer requirements that ensure the freshness of foods. The application of the space technology meant that the small business would be able to continue to market its cases without incurring expenses that could threaten the viability of the business, and the future of several dozen jobs. Research and development improvements in air flow distribution and refrigeration coil technology contributed greatly to certifying Displaymor's showcases given the new federal regulations. These modifications resulted in a refrigerator case that will keep foods cooler, longer. Such changes maintained the openness of the display, critical to customer visibility and accessibility, impulse buying, and cross-merchandising.

Air transportation energy efficiency - Alternatives and implications

NASA Technical Reports Server (NTRS)

Williams, L. J.

1976-01-01

Results from recent studies of air transportation energy efficiency alternatives are discussed, along with some of the implications of these alternatives. The fuel-saving alternatives considered include aircraft operation, aircraft modification, derivative aircraft, and new aircraft. In the near-term, energy efficiency improvements should be possible through small improvements in fuel-saving flight procedures, higher density seating, and higher load factors. Additional small near-term improvements could be obtained through aircraft modifications, such as the relatively inexpensive drag reduction modifications. Derivatives of existing aircraft could meet the requirements for new aircraft and provide energy improvements until advanced technology is available to justify the cost of a completely new design. In order to obtain significant improvements in energy efficiency, new aircraft must truly exploit advanced technology in such areas as aerodynamics, composite structures, active controls, and advanced propulsion.

LISA Technology Development at GSFC

NASA Technical Reports Server (NTRS)

Thorpe, James Ira; McWilliams, S.; Baker, J.

2008-01-01

The prime focus of LISA technology development efforts at NASA/GSFC has been in LISA interferometry, specifically in the area of laser frequency noise mitigation. Laser frequency noise is addressed through a combination of stabilization and common-mode rejection. Current plans call for two stages of stabilization, pre-stabilization to a local frequency reference and further stabilization using the constellation as a frequency reference. In order for these techniques to be used simultaneously, the pre-stabilization step must provide an adjustable frequency offset. Here, we report on a modification to the standard modulation/demodulation techniques used to stabilize to optical cavities that generates a frequency-tunable reference from a fixed-length cavity. This technique requires no modifications to the cavity itself and only minor modifications to the components. The measured noise performance and dynamic range of the laboratory prototype meets the LISA requirements.

Human germline genetic modification: scientific and bioethical perspectives.

PubMed

Smith, Kevin R; Chan, Sarah; Harris, John

2012-10-01

The latest mammalian genetic modification technology offers efficient and reliable targeting of genomic sequences, in the guise of designer genetic recombination tools. These and other improvements in genetic engineering technology suggest that human germline genetic modification (HGGM) will become a safe and effective prospect in the relatively near future. Several substantive ethical objections have been raised against HGGM including claims of unacceptably high levels of risk, damage to the status of future persons, and violations of justice and autonomy. This paper critically reviews the latest GM science and discusses the key ethical objections to HGGM. We conclude that major benefits are likely to accrue through the use of safe and effective HGGM and that it would thus be unethical to take a precautionary stance against HGGM. Copyright © 2012 IMSS. Published by Elsevier Inc. All rights reserved.

LISA Beyond Einstein: From the Big Bang to Black Holes. LISA Technology Development at GSFC

NASA Technical Reports Server (NTRS)

Thorpe, James Ira

2008-01-01

This viewgraph presentation reviews the work that has been ongoing at the Goddard Space Flight Center (GSFC) in the development of the technology to be used in the Laser Interferometer Space Antenna (LISA) spacecrafts. The prime focus of LISA technology development efforts at NASA/GSFC has been in LISA interferometry. Specifically efforts have been made in the area of laser frequency noise mitigation. Laser frequency noise is addressed through a combination of stabilization and common-mode rejection. Current plans call for two stages of stabilization, pre-stabilization to a local frequency reference and further stabilization using the constellation as a frequency reference. In order for these techniques to be used simultaneously, the pre-stabilization step must provide an adjustable frequency offset. This presentation reports on a modification to the standard modulation/demodulation technique used to stabilize to optical cavities that generates a frequency-tunable reference from a fixed length cavity. This technique requires no modifications to the cavity itself and only minor modifications to the components. The measured noise performance and dynamic range of the laboratory prototype meet the LISA requirements.

Hollywood's Conversion to Color: The Technological, Economic and Aesthetic Factors.

ERIC Educational Resources Information Center

Kindem, Forham A.

1979-01-01

Discusses the film industry's conversion to color cinematography in the period between the 1920s and 1960s. Cites economic considerations, technological modifications, and aesthetic preferences by audiences as factors in this development. (JMF)

Exploring Ways of Influencing Transport Behaviors by Using Telecommunications Technologies

DOT National Transportation Integrated Search

2004-06-01

Information technology can facilitate substitution and modification of transportation behaviors. Distance Learning (DL) can replace library work, meetings, and some traditional face-to-face class meetings. For off-campus full-time students, and for p...

Acceptance of genetically modified foods: the relation between technology and evaluation.

PubMed

Tenbült, Petra; De Vries, Nanne K; van Breukelen, Gerard; Dreezens, Ellen; Martijn, Carolien

2008-07-01

This study investigates why consumers accept different genetically modified food products to different extents. The study shows that whether food products are genetically modified or not and whether they are processed or not are the two important features that affect the acceptance of food products and their evaluation (in terms of perceived healthiness, naturalness, necessity and tastiness). The extent to which these evaluation attributes and acceptance of a product are affected by genetic modification or processing depends on whether the product is negatively affected by the other technology: Any technological change to a 'natural' product (when nonprocessed products are genetically modified or when non-genetically modified products are processed) affect evaluation and acceptance stronger than a change to an technologically adapted product (when processed products are also genetically modified or vice versa). Furthermore, evaluation attributes appear to mediate the effects of genetic modification and processing on acceptance.

Supercritical fluid technology: a promising approach in pharmaceutical research.

PubMed

Girotra, Priti; Singh, Shailendra Kumar; Nagpal, Kalpana

2013-02-01

Supercritical fluids possess the unique properties of behaving like liquids and gases, above their critical point. Supercritical fluid technology has recently emerged as a green and novel technique for various processes such as solubility enhancement of poorly soluble drugs, plasticization of polymers, surface modification, nanosizing and nanocrystal modification, and chromatographic extraction. Research interest in this area has been fuelled because of the numerous advantages that the technology offers over the conventional methods. This work aims to review the merits, demerits, and various processes such as rapid expansion of supercritical solutions (RESS), particles from gas saturated solutions (PGSS), gas antisolvent process (GAS), supercritical antisolvent process (SAS) and polymerization induced phase separation (PIPS), that have enabled this technology to considerably raise the interest of researchers over the past two decades. An insight has been given into the numerous applications of this technology in pharmaceutical industry and the future challenges which must be appropriately dealt with to make it effective on a commercial scale.

KSC-05pd2533

NASA Image and Video Library

2005-11-30

KENNEDY SPACE CENTER, FLA. - In Orbiter Processing Facility Bay 2, United Space Alliance technician Michael Vanwart installs thermal protection system blankets in the nose cap of space shuttle Endeavour. Endeavour recently came out of a nearly two-year Orbiter Major Modification period which began in December 2003. Engineers and technicians spent 900,000 hours performing 124 modifications to the vehicle. These included all recommended return-to-flight safety modifications, bonding more than 1,000 thermal protection system tiles and inspecting more than 150 miles of wiring throughout the orbiter. Shuttle major modification periods are scheduled at regular intervals to enhance safety and performance, infuse new technology, and allow for thorough inspections of the airframe and wiring of the vehicles. This was the second of these modification periods performed entirely at Kennedy Space Center. Endeavour's previous modification was completed in March 1997.

KSC-05pd2531

NASA Image and Video Library

2005-11-30

KENNEDY SPACE CENTER, FLA. - In Orbiter Processing Facility bay 2, United Space Alliance technician Michael Vanwart prepares to install thermal protection system blankets in the nose cap of space shuttle Endeavour. Endeavour recently came out of a nearly two-year Orbiter Major Modification period which began in December 2003. Engineers and technicians spent 900,000 hours performing 124 modifications to the vehicle. These included all recommended return-to-flight safety modifications, bonding more than 1,000 thermal protection system tiles and inspecting more than 150 miles of wiring throughout the orbiter. Shuttle major modification periods are scheduled at regular intervals to enhance safety and performance, infuse new technology, and allow for thorough inspections of the airframe and wiring of the vehicles. This was the second of these modification periods performed entirely at Kennedy Space Center. Endeavour's previous modification was completed in March 1997.

KSC-05pd2532

NASA Image and Video Library

2005-11-30

KENNEDY SPACE CENTER, FLA. - In Orbiter Processing Facility Bay 2, United Space Alliance technician Michael Vanwart installs thermal protection system blankets in the nose cap of space shuttle Endeavour. Endeavour recently came out of a nearly two-year Orbiter Major Modification period which began in December 2003. Engineers and technicians spent 900,000 hours performing 124 modifications to the vehicle. These included all recommended return-to-flight safety modifications, bonding more than 1,000 thermal protection system tiles and inspecting more than 150 miles of wiring throughout the orbiter. Shuttle major modification periods are scheduled at regular intervals to enhance safety and performance, infuse new technology, and allow for thorough inspections of the airframe and wiring of the vehicles. This was the second of these modification periods performed entirely at Kennedy Space Center. Endeavour's previous modification was completed in March 1997.

ARSENIC REMOVAL FROM DRINKING WATER BY PROCESS MODIFICATION TO COAGULATION/FILTRATION. USEPA DEMONSTRATION PROJECT AT LIDGERWOOD, ND. FINAL PERFORMANCE EVALUATION REPORT

EPA Science Inventory

This report documents the activities performed and the results obtained for the arsenic removal treatment technology demonstration project at the Lidgerwood, North Dakota site. The objectives of the project were to evaluate: (1) the effectiveness of process modifications to an e...

The Substitution Augmentation Modification Redefinition (SAMR) Model: A Critical Review and Suggestions for Its Use

ERIC Educational Resources Information Center

Hamilton, Erica R.; Rosenberg, Joshua M.; Akcaoglu, Mete

2016-01-01

The Substitution, Augmentation, Modification, and Redefinition (SAMR) model is a four-level, taxonomy-based approach for selecting, using, and evaluating technology in K-12 settings (Puentedura 2006). Despite its increasing popularity among practitioners, the SAMR model is not currently represented in the extant literature. To focus the ongoing…

Preparation of Mach-Zehnder interferometric photonic biosensors by inkjet printing technology

NASA Astrophysics Data System (ADS)

Strasser, Florian; Melnik, Eva; Muellner, Paul; Jiménez-Meneses, Pilar; Nechvile, Magdalena; Koppitsch, Guenther; Lieberzeit, Peter; Laemmerhofer, Michael; Heer, Rudolf; Hainberger, Rainer

2017-05-01

Inkjet printing is a versatile method to apply surface modification procedures in a spatially controlled, cost-effective and mass-fabrication compatible manner. Utilizing this technology, we investigate two different approaches for functionalizing label-free optical waveguide based biosensors: a) surface modification with amine-based functional polymers (biotin-modified polyethylenimine (PEI-B)) employing active ester chemistry and b) modification with dextran based hydrogel thin films employing photoactive benzophenone crosslinker moieties. Whereas the modification with PEI-B ensures high receptor density at the surface, the hydrogel films can serve both as a voluminous matrix binding matrix and as a semipermeable separation layer between the sensor surface and the sample. We use the two surface modification strategies both individually and in combination for binding studies towards the detection of the protein inflammation biomarker, C-reactive protein (CRP). For the specific detection of CRP, we compare two kinds of capture molecules, namely biotinylated antibodies and biotinylated CRP-specific DNA based aptamers. Both kinds of capture molecules were immobilized on the PEI-B by means of streptavidin-biotin affinity binding. As transducer, we use an integrated four-channel silicon nitride (Si3N4) waveguide based Mach-Zehnder interferometric (MZI) photonic sensing platform operating at a wavelength of 850nm (TM-mode).

Boards on the Move: Surfboards, Skateboards, Snowboards, and Kiteboards

ERIC Educational Resources Information Center

Moye, Johnny J.; Ritz, John M.

2009-01-01

Technological advances through mathematics and science have made possible the modification of boarding sports. This article discusses the development of sport technologies that use boards and also touches on the social and cultural effects of the new technologies. It identifies many new forms of sports equipment that were spawned from modifying…

Assistive technology and home modification for people with neurovisual deficits.

PubMed

Copolillo, Al; Ivanoff, Synneve Dahlin

2011-01-01

People with neurovisual deficits from acquired brain injuries and other neurological disabilities can benefit from the array of assistive technologies and home modifications available to the larger vision impairment population, especially when symptoms are mild and associated neurological conditions are few. Optics, proper lighting, and magnification to increase the perceived size of both objects and reading material and to improve contrast sensitivity have been shown to be beneficial. Innovative technologies, universally designed for safe independent living and community participation are gradually developing and show promise for addressing the needs of this population. This article highlights technologies that may be useful for people with neurovisual deficits and describes the evidence to support their training and use. The use of various types of eyewear to reduce falls; prisms and telescopic lenses to improve visual attention and minimize the impact of visual field deficits; and technologies to improve computer use, wayfinding, and home safety are discussed. While there remains substantial need for further research and development focusing on the needs of people with vision impairments from neurological conditions, practitioners can use technology with caution to improve functional outcomes.

Surface Modification of Intraocular Lenses

PubMed Central

Huang, Qi; Cheng, George Pak-Man; Chiu, Kin; Wang, Gui-Qin

2016-01-01

Objective: This paper aimed to review the current literature on the surface modification of intraocular lenses (IOLs). Data Sources: All articles about surface modification of IOLs published up to 2015 were identified through a literature search on both PubMed and ScienceDirect. Study Selection: The articles on the surface modification of IOLs were included, but those on design modification and surface coating were excluded. Results: Technology of surface modification included plasma, ion beam, layer-by-layer self-assembly, ultraviolet radiation, and ozone. The main molecules introduced into IOLs surface were poly (ethylene glycol), polyhedral oligomeric silsesquioxane, 2-methacryloyloxyethyl phosphorylcholine, TiO2, heparin, F-heparin, titanium, titanium nitride, vinyl pyrrolidone, and inhibitors of cytokines. The surface modification either resulted in a more hydrophobic lens, a more hydrophilic lens, or a lens with a hydrophilic anterior and hydrophobic posterior surface. Advances in research regarding surface modification of IOLs had led to a better biocompatibility in both in vitro and animal experiments. Conclusion: The surface modification is an efficient, convenient, economic and promising method to improve the biocompatibility of IOLs. PMID:26830993

Factor XIII deficiency in Iran: a comprehensive review of the literature.

PubMed

Dorgalaleh, Akbar; Naderi, Majid; Hosseini, Maryam Sadat; Alizadeh, Shaban; Hosseini, Soudabeh; Tabibian, Shadi; Eshghi, Peyman

2015-04-01

Factor XIII deficiency (FXIIID) is a rare bleeding disorder with an estimated prevalence of 1 in 2-million population worldwide. In Iran, a Middle Eastern country with a high rate of consanguineous marriages, there are approximately 473 patients afflicted with FXIIID. An approximately 12-fold higher prevalence of FXIIID is estimated in Iran in comparison with overall worldwide frequency. In this study, we have undertaken a comprehensive review on different aspects of FXIIID in the Iranian population. The distribution of this disease in different regions of Iran reveals that Sistan and Baluchestan Province has not only the highest number of patients with FXIIID in Iran but the highest global incidence of this condition. Among Iranian patients, umbilical cord bleeding, hematoma, and prolonged wound bleeding are the most frequent clinical manifestations. There are several disease causing mutations in Iranian patients with FXIIID, with Trp187Arg being the most common mutation in FXIIID in Iran. Traditionally, the management of FXIIID in Iran was only based on administration of fresh frozen plasma or cryoprecipitate, until 2009 when FXIII concentrate became available for patient management. Various studies have evaluated the efficacy and safety of prophylactic regimens in different situations with valuable findings. Although the focus of this study is on Iran, it offers considerable insight into FXIIID, which can be applied more extensively to improve the management and quality of life in all affected patients. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

A randomised study of perioperative esmolol infusion for haemodynamic stability during major vascular surgery; rationale and design of DECREASE-XIII.

PubMed

Bakker, E J; Ravensbergen, N J; Voute, M T; Hoeks, S E; Chonchol, M; Klimek, M; Poldermans, D

2011-09-01

This article describes the rationale and design of the DECREASE-XIII trial, which aims to evaluate the potential of esmolol infusion, an ultra-short-acting beta-blocker, during surgery as an add-on to chronic low-dose beta-blocker therapy to maintain perioperative haemodynamic stability during major vascular surgery. A double-blind, placebo-controlled, randomised trial. A total of 260 vascular surgery patients will be randomised to esmolol or placebo as an add-on to standard medical care, including chronic low-dose beta-blockers. Esmolol is titrated to maintain a heart rate within a target window of 60-80 beats per minute for 24 h from the induction of anaesthesia. Heart rate and ischaemia are assessed by continuous 12-lead electrocardiographic monitoring for 72 h, starting 1 day prior to surgery. The primary outcome measure is duration of heart rate outside the target window during infusion of the study drug. Secondary outcome measures will be the efficacy parameters of occurrence of cardiac ischaemia, troponin T release, myocardial infarction and cardiac death within 30 days after surgery and safety parameters such as the occurrence of stroke and hypotension. This study will provide data on the efficacy of esmolol titration in chronic beta-blocker users for tight heart-rate control and reduction of ischaemia in patients undergoing vascular surgery as well as data on safety parameters. Copyright © 2011 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

The Pic du Midi solar survey

NASA Astrophysics Data System (ADS)

Koechlin, L.

2015-12-01

We carry a long term survey of the solar activity with our coronagraphic system at Pic du Midi de Bigorre in the French Pyrenees (CLIMSO). It is a set of two solar telescopes and two coronagraphs, taking one frame per minute for each of the four channels : Solar disk in H-α (656.28 nm), prominences in H-α, disk in Ca II (393.3 nm), prominences in He I (1083 nm), all year long, weather permitting. Since 2015 we also take images of the FeXIII corona (1074.7 nm) at the rate of one every 10 minutes. These images cover a large field: 1.25 solar diameter, 2k*2K pixels, and are freely downloadable form a database. The improvements made since 2015 concern an autoguiding system for better centering of the solar disk behind the coronagraphic masks, and a new Fe XIII channel at λ=1074.7 nm. In the near future we plan to provide radial velocity maps of the disc and polarimetry maps of the disk and corona. This survey took its present form in 2007 and we plan to maintain image acquisition in the same or better experimental conditions for a long period: one or several solar cycles if possible. During the partial solar eclipse of March 20, 2015, the CLIMSO instruments and the staff at Pic du Midi operating it have provided several millions internet users with real time images of the Sun and Moon during all the phenomenon.

FOREWORD: The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) (Pine Mountain, Georgia, USA, 19-23 April 2009) The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) (Pine Mountain, Georgia, USA, 19-23 April 2009)

NASA Astrophysics Data System (ADS)

Orlando, Thomas M.; Diebold, Ulrike

2010-03-01

The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) took place from 19-23 April 2009 in Pine Mountain, Georgia, USA. This was the 12th conference in a strong and vibrant series, which dates back to the early 1980s. DIET XII continued the tradition of exceptional interdisciplinary science and focused on the study of desorption and dynamics induced by electronic excitations of surfaces and interfaces. The format involved invited lectures, contributed talks and a poster session on the most recent developments and advances in this area of surface physics. The Workshop International Steering Committee and attendees wish to dedicate DIET XII to the memory of the late Professor Theodore (Ted) Madey. Ted was one of the main pioneers of this field and was one of the primary individuals working to keep this area of science exciting and adventurous. His overall contributions to surface science were countless and his contributions to the DIET field and community were enormous. He is missed and remembered by many friends and colleagues throughout the world. The papers collected in this issue cover many of the highlights of DIET XII. Topics include ultrafast electron transfer at surfaces and interfaces, quantum and spatially resolved mapping of surface dynamics and desorption, photon-, electron- and ion-beam induced processes at complex interfaces, the role of non-thermal desorption in astrochemistry and astrophysics and laser-/ion-based methods of examining soft matter and biological media. Although the workshop attracted many scientists active in the general area of non-thermal surface processes, DIET XII also attracted many younger scientists (i.e., postdoctoral fellows, advanced graduate students, and a select number of advanced undergraduate students). This field has had an impact in a number of areas including nanoscience, device physics, astrophysics, and now biophysics. We believe that this special issue of Journal of Physics: Condensed Matter will help foster further progress in the study of DIET processes. Since the field remains vibrant and exciting, the workshop series will continue with DIET XIII. Professor Richard Palmer (University of Birmingham, UK) will chair DIET XIII in the UK in early summer 2012. We gratefully acknowledge financial support from SPECS, HIDEN Analytical, BRUKER, The United States National Science Foundation, Georgia Institute of Technology and The State University of New Jersey, Rutgers.

Update: Mechanisms underlying N6-methyladenosine modification of eukaryotic mRNA

PubMed Central

Wang, Yang; Zhao, Jing Crystal

2016-01-01

Summary Eukaryotic messenger RNA (mRNA) undergoes chemical modification both at the 5′cap [1, 2] and internally [3–14]. Among internal modifications, m6A, by far the most abundant, is present in all eukaryotes examined, including mammals [3–6], flies [15], plants [16, 17] and yeast [18, 19]. m6A modification plays an essential role in diverse biological processes. Over the past few years, our knowledge relevant to establishment and function of this modification has grown rapidly. This review focuses on technologies that have facilitated m6A detection in mRNAs, identification of m6A methylation enzymes and binding proteins, and potential functions of the modification at the molecular level. Regarding m6A function at cellular or organismal levels or in disease, please refer to other recent reviews [20–23]. PMID:27793360

40 CFR 57.102 - Eligibility.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., but not the cost of compliance). (i) Retrofit control technologies. (A) Sulfuric acid plant in conjunction with an adequately demonstrated replacement technology or process modification; (B) Magnesium... burning in conjunction with acid plant; (D) Electric Furnace; (E) Noranda process; (F) Fluid bed roaster...

Air Conditioning Modifications for the GMC RTSII Series 01 Coach (Model TH 8201)

DOT National Transportation Integrated Search

1982-10-01

As part of its bus and paratransit technology research and development efforts, the Urban Mass Transportation Administration is conducting the Bus Subsystems Technology Project to help the transit bus industry solve serious equipment problems. The pr...

40 CFR 57.102 - Eligibility.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., but not the cost of compliance). (i) Retrofit control technologies. (A) Sulfuric acid plant in conjunction with an adequately demonstrated replacement technology or process modification; (B) Magnesium... burning in conjunction with acid plant; (D) Electric Furnace; (E) Noranda process; (F) Fluid bed roaster...

40 CFR 57.102 - Eligibility.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., but not the cost of compliance). (i) Retrofit control technologies. (A) Sulfuric acid plant in conjunction with an adequately demonstrated replacement technology or process modification; (B) Magnesium... burning in conjunction with acid plant; (D) Electric Furnace; (E) Noranda process; (F) Fluid bed roaster...

40 CFR 57.102 - Eligibility.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., but not the cost of compliance). (i) Retrofit control technologies. (A) Sulfuric acid plant in conjunction with an adequately demonstrated replacement technology or process modification; (B) Magnesium... burning in conjunction with acid plant; (D) Electric Furnace; (E) Noranda process; (F) Fluid bed roaster...

40 CFR 57.102 - Eligibility.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., but not the cost of compliance). (i) Retrofit control technologies. (A) Sulfuric acid plant in conjunction with an adequately demonstrated replacement technology or process modification; (B) Magnesium... burning in conjunction with acid plant; (D) Electric Furnace; (E) Noranda process; (F) Fluid bed roaster...

40 CFR 60.14 - Modification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... physical change, or change in the method of operation, at an existing electric utility steam generating... projects that are awarded funding from the Department of Energy as permanent clean coal technology... installation, operation, cessation, or removal of a temporary clean coal technology demonstration project is...

Gene targeting in embryonic stem cells, II: conditional technologies

USDA-ARS?s Scientific Manuscript database

Genome modification via transgenesis has allowed researchers to link genotype and phenotype as an alternative approach to the characterization of random mutations through evolution. The synergy of technologies from the fields of embryonic stem (ES) cells, gene knockouts, and protein-mediated recombi...

On the predominance of the radial component of the magnetic field in the solar corona

NASA Technical Reports Server (NTRS)

Habbal, S. R.; Woo, R.; Arnaud, J.

2002-01-01

In this paper, the polarized intensity measurements of the Fe XIII 10747 A line described by Arnaud are placed, for the first time, in the context of the corresponding pB images from the HAO Mauna Loa MkIII K-Coronameter, which first became available in 1980. It is shown how the predominance of the radial direction of the coronal magnetic field at solar maximum is consistent with radially expanding magnetic field lines coexisting with the large-scale structures associated with streamers.

Nutritional Status Assessment of Marines before and after the Installation of the ’Multi-Restaurant’ Food Service System at the Twentynine Palms Marine Corps Base, California

DTIC Science & Technology

1984-12-01

Biochemical and Dietary Measurements 129 Table 40 - Correlations Between Biochemical and Dietary Measurements 130 Table 41 - Serum Vitamin A Levels of 29...Palms Personnel By Average Daily Vitamin A Consumption 131 Table 42 - Average Daily Vitamin A Intake of Marines By Serum Vitamin A Levels 132 xiii Z...vitamin A levels increased further to a high of 80% in the female personnel. The poor vitamin A nutritional status was reflected also in the low serum

Brittle Materials Design, High Temperature Gas Turbine

DTIC Science & Technology

1974-09-01

Fabrication 4.2 Rotor Blade Development 4.2.1 WISEC Rotor Blade Analysis Page No. i 11 ill i v v xiii 1 11 11 13 14 15 15 17 32 42 55...in Examples of commonly observed flaws *" ™tor t^ade g ^ ■7 ~,n „„i i ?i Rnth entrapped gas voids and siiii-iiNis^ v ^x rr...aluminas C11-’ has indicated that 40 or more samples are necessary to determine the Weibull material constants m and a . V Future spin testing

Descriptive Summaries of the Research, Development, Test and Evaluation, Army Appropriation FY 1982. Supporting Data FY 1982. Supporting Data FY 1982, Budget Estimate Submitted to Congress January 1981, Amended 30 March 1981. Volume III.

DTIC Science & Technology

1981-01-01

ACTIVITIES .......... ............................ 111-548 3/ de ~ &04A.... ~UNCLASSIFIED xiii 0- 4 UNCLASSIFIED FY 1932 ROTE CONGRESSIONAI. DESCRIPTIVE...Title: Comeunicatiois gnlineerin De -elo pmnt DOD Mission Area: i256 - Tactical Communications Sudget Activity: 04 - TactictI Programs Into the...tconditions ot heavy miiltary traffic, high speeds, and severe weather. Army Remote Sensors (REMS) were used to provide 4-cnrity of the Olympic Village complex

Rare coagulation disorders: fibrinogen, factor VII and factor XIII.

PubMed

de Moerloose, P; Schved, J-F; Nugent, D

2016-07-01

Rare coagulation disorders (RCDs) include the inherited deficiencies of fibrinogen, factor (F) II, FV, combined FV and VIII, FVII, FX, combined FVII and X, FXI, FXIII and combined congenital deficiency of vitamin K-dependent factors (VKCFDs). Despite their rarity, a deep comprehension of all these disorders is essential to really understand haemostasis. Indeed, even if they share some common features each RCD has some particularity which makes it unique. In this review, we focus on three disorders: fibrinogen, FVII and FXIII. © 2016 John Wiley & Sons Ltd.

SLB-STO-D ANALYSIS REPORT: MODELING AND SIMULATION ANALYSIS OF FUEL, WATER, AND WASTE REDUCTIONS IN BASE CAMPS: 50, 300, AND 1000 PERSONS

DTIC Science & Technology

2017-08-21

panels only produce power when the sun is out, turbines only produce power when there xiii is wind , etc. For these sources to be fully utilized...hybrid energy system mounted on a towable trailer consisting of an onboard diesel generator, solar panels, wind turbines , and an energy storage...limited to certain times of day—solar panels only produce power when the sun is out, turbines only produce power when there is wind , etc. For these

Analysis of DNA Sequences by an Optical Time-Integrating Correlator: Proof-of-Concept Experiments.

DTIC Science & Technology

1992-05-01

DNA ANALYSIS STRATEGY 4 2.1 Representation of DNA Bases 4 2.2 DNA Analysis Strategy 6 3.0 CUSTOM GENERATORS FOR DNA SEQUENCES 10 3.1 Hardware Design 10...of the DNA bases where each base is represented by a 7-bits long pseudorandom sequence. 5 Figure 4: Coarse analysis of a DNA sequence. 7 Figure 5: Fine...a 20-bases long database. 32 xiii LIST OF TABLES PAGE Table 1: Short representations of the DNA bases where each base is represented by 7-bits long

Nucleic acid binding drugs. Part XIII. Molecular motion in a drug-nucleic acid model system: thermal motion analysis of a proflavine-dinucleoside crystal structure.

PubMed Central

Aggarwal, A K; Neidle, S

1985-01-01

The high-resolution crystal structure of the intercalation complex between proflavine and cytidylyl-3',5'-guanosine (CpG) has been studied by thermalmotion analysis. This has provided information on the translational and librational motions of individual groups in the complex. Many of these motions are similar to, though of larger magnitude than in uncomplexed dinucleosides. Pronounced librational effects were observed along the base pairs and in the plane of the drug chromophore. PMID:4034394

Studi prospettici sulla fascia dell'eclittica dell'Atlante Farnese

NASA Astrophysics Data System (ADS)

Sigismondi, Costantino; Calore, Carlo

2017-05-01

We present a study, carried out on photographic images, of the ecliptic strip of the Atlas Farnese, a statue found before 1550 in Rome. This statue was supposedly carved according to the celestial catalogue compiled around 129 b. C. by Hypparchus but subsequently lost. The obliquity of the ecliptic is deduced as 24.1° ± 0.5° along with the width of the strip of 7.5°, in good agreement with Ptolemy's Almagest table of planetary inclinations (Book XIII.5).

The genetic control of contact sensitization to inorganic metal compounds in guinea-pigs

PubMed Central

Polák, L.; Barnes, J. M.; Turk, J. L.

1968-01-01

Only a proportion of outbred guinea-pigs can be sensitized to K2Cr2O7, BeF2 and HgCl2. Inbred Strain II can be sensitized to K2Cr2O7 and BeF2, but not to HgCl2. Inbred strain XIII can be sensitized to HgCl2 but not to K2Cr2O7 or BeF2. The ability to become sensitized appears to be transmitted as a dominant characteristic which is not sex linked. PMID:5656877

An Experimental Study of the Driving Mechanism and Control of the Unsteady Shock Induced Turbulent Separation in a Mach 5 Compression Corner Flow.

DTIC Science & Technology

1992-01-01

vili Table of Contents Section Page List of Tables xiii List of Figures xiv Nomenclature xxii 1 Introduction 1 1.1 Motivation 1 1.2 Objective of...Introduction 1.1 Motivation The mid-1980’s saw a renewed interest in hypersonic flight. Motivated by the achievements of the American Space Transportation... measuments made downstrem of the compreson corner. 4.2.2 VITA Technique Another approach to event detection was applied to the fluctuating pitot

Smart Materials for Army Structures

DTIC Science & Technology

1992-04-01

86. . 3 0.0 IMIA8 0 --’O IM S. B .88 . -I 30.0- 10.0 0 .0XI Fig. X4 Electrico o flte i ( eatv 2. andth It 0 / (A) 0-0 [90/0/90] 30.0 u...accomplished computationally, 137 i : D L (B) (C) --- Fig. X~III A demonstration of auto -rotation on a D-shaped blade of a Lancliester propellecr. 138 I...Conductive Polymers and Plastics, Chapman and Hall, 1989. Margolis, J.M., "Composites Challenge Metals for Aircraft/ Auto Panel Applications,’ Machine and

Recent findings and technological advances in phosphoproteomics for cells and tissues.

PubMed

von Stechow, Louise; Francavilla, Chiara; Olsen, Jesper V

2015-01-01

Site-specific phosphorylation is a fast and reversible covalent post-translational modification that is tightly regulated in cells. The cellular machinery of enzymes that write, erase and read these modifications (kinases, phosphatases and phospho-binding proteins) is frequently deregulated in different diseases, including cancer. Large-scale studies of phosphoproteins - termed phosphoproteomics - strongly rely on the use of high-performance mass spectrometric instrumentation. This powerful technology has been applied to study a great number of phosphorylation-based phenotypes. Nevertheless, many technical and biological challenges have to be overcome to identify biologically relevant phosphorylation sites in cells and tissues. This review describes different technological strategies to identify and quantify phosphorylation sites with high accuracy, without significant loss of analysis speed and reproducibility in tissues and cells. Moreover, computational tools for analysis, integration and biological interpretation of phosphorylation events are discussed.

Epigenomics in cancer management

PubMed Central

Costa, Fabricio F

2010-01-01

The identification of all epigenetic modifications implicated in gene expression is the next step for a better understanding of human biology in both normal and pathological states. This field is referred to as epigenomics, and it is defined as epigenetic changes (ie, DNA methylation, histone modifications and regulation by noncoding RNAs such as microRNAs) on a genomic scale rather than a single gene. Epigenetics modulate the structure of the chromatin, thereby affecting the transcription of genes in the genome. Different studies have already identified changes in epigenetic modifications in a few genes in specific pathways in cancers. Based on these epigenetic changes, drugs against different types of tumors were developed, which mainly target epimutations in the genome. Examples include DNA methylation inhibitors, histone modification inhibitors, and small molecules that target chromatin-remodeling proteins. However, these drugs are not specific, and side effects are a major problem; therefore, new DNA sequencing technologies combined with epigenomic tools have the potential to identify novel biomarkers and better molecular targets to treat cancers. The purpose of this review is to discuss current and emerging epigenomic tools and to address how these new technologies may impact the future of cancer management. PMID:21188117

Present and future trends of laser materials processing in Japan

NASA Astrophysics Data System (ADS)

Matsunawa, Akira

1991-10-01

Lasers quickly penetrated into Japanese industries in the mid-80s. The paper reviews the present situation of industrial lasers and their applications in Japanese industries for materials removal, joining, and some surface modification technologies as well as their economical evaluation compared with competitive technologies. Laser cutting of metallic and nonmetallic thin sheets is widely prevalent even in small scale industries as a flexible manufacturing tool. As for the laser welding is concerned, industrial applications are rather limited in mass production lines. This mainly comes from the fact that the present laser technologies have not employed the adaptive control because of the lack of sensors, monitoring, and control systems which can tolerate the high-precision and high-speed processing. In spite of this situation, laser welding is rapidly increasing in recent years in industries such as automotive, machinery, electric/electronic, steel, heavy industries, etc. Laser surface modification technologies have attracted significant interest from industrial people, but actual application is very limited today. However, the number of R&D papers is increasing year by year. The paper also reviews these new technology trends in Japan.

EVALUATION OF WILDER CONSTRUCTION COMPANY'S MATCON ™ COVER TECHNOLOGY - INNOVATIVE TECHNOLOGY EVALUATION REPORT

EPA Science Inventory

MatCon is a polymer modified asphalt material designed specifically for waste containment applications. The modifications to the material differentiate it from conventional paving asphalt by minimizing the damaging effects of environmental exposure that could detract from the de...

The Hidden Cost of Saying No!

ERIC Educational Resources Information Center

Dyson, Freeman J.

1975-01-01

Four problems of the regulation of technological development are reviewed: Djerassi's study of the regulation of chemical birth control agents; the downfall of the American supersonic airliner; climate modification; and genetic engineering. The author examines technology and the nature of bureaucratic institutions with respect to the political…

Physical characteristics of genetically-altered wheat related to technological protein separation

USDA-ARS?s Scientific Manuscript database

Wheat protein is a technologically challenging substrate for food and non-food applications because of its compositional diversity and susceptibility to denaturation. Genetic modification could be used to create cultivars capable of producing more uniform or focused and novel protein compositions t...

75 FR 59674 - Make Inoperative Exemptions; Vehicle Modifications To Accommodate People With Disabilities, Side...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-28

... that many vehicles will depend on side impact air bag technology to meet all of the injury criteria of... ``lead to the installation of new technologies, such as side curtain air bags and torso side air bags... is side air bag technology incorporated in the vehicle's roof rail (side air bag curtain), door, and...

Technology Access from the FS-X Radar Program. Lessons for Technology Transfer and U.S. Acquisition Policy

DTIC Science & Technology

1994-01-01

and subsequent bilateral negotiations entitle the United States to the "free and automatic flowback " of all Japanese "derived technology," defined as...White Paper, US. Departments of Commerce, Defense, and Air Force, May 1991. 3Pree and automatic flowback of derived technology has precedent in licensed...By receiving indigenous Japanese FS-X technology, US. firms may be obligating themselves to provide free flowback to Japan of any modifications they

BENCH-SCALE STUDIES TO IDENTIFY PROCESS PARAMETERS CONTROLLING REBURNING WITH PULVERIZED COAL

EPA Science Inventory

The report addresses the evaluation of a technology which is a combination of two technologies used to control the atmospheric emission of NOx by stationary sources: (1) combustion modification (controls flame temperature and maximizes fuel-rich residence time to minimize NOx for...

Spray drift reduction evaluations of spray nozzles using a standardized testing protocol

USDA-ARS?s Scientific Manuscript database

The development and testing of drift reduction technologies has come to the forefront of application research in the past few years in the United States. Drift reduction technologies (DRTs) can be spray nozzles, sprayer modifications, spray delivery assistance, spray property modifiers (adjuvants),...

Are High School Students Prepared for a Brave New World?

ERIC Educational Resources Information Center

Blake, Deborah

1984-01-01

Describes Notre Dame High School's (California) integrated bioethics course, which contains units on basic concepts of goals, rights, and duty ethics; reproductive technologies; genetic technologies; death and dying; behavior modification; and experiments with human subjects. Provides a bibliography of student and teacher materials. (DMM)

Curricular Implications of Virtual World Technology: A Review of Business Applications

ERIC Educational Resources Information Center

Cyphert, Dale; Wurtz, M. Susan; Duclos, Leslie K.

2013-01-01

As business organizations grow increasingly virtual, traditional principles of organizational communication require examination and modification. This article considers the curricular implications of the growing business uses of virtual world technology through three different lenses--students as employee-users, students as strategic designers and…

Using Technology to Support Teachers' Lesson Modifications during Lesson Study

ERIC Educational Resources Information Center

Skultety, Lisa; Gonzalez, Gloriana; Vargas, Gabriela

2017-01-01

Lesson study is a professional development activity that increases teachers' attention to student thinking. However, coordinating teachers' live observations of a lesson can be challenging. Using the framework of "distributed cognition," we investigate whether technology supports teachers' examination of student thinking and aids the…

The Search for Extraterrestrial Intelligence.

ERIC Educational Resources Information Center

Jones, Barrie W.

2003-01-01

Traces the efforts of Searching for Extraterrestrial Technological Intelligence (SETI) since 1960 when a radio-telescope was used to see if any messages were being sent from the vicinity of two nearby stars. Describes attempts to detect microwave/optical signals and technological modification of the cosmic environment. (Author/KHR)

Thrombin-dependent Incorporation of von Willebrand Factor into a Fibrin Network*

PubMed Central

Miszta, Adam; Pelkmans, Leonie; Lindhout, Theo; Krishnamoorthy, Ganeshram; de Groot, Philip G.; Hemker, Coenraad H.; Heemskerk, Johan W. M.; Kelchtermans, Hilde; de Laat, Bas

2014-01-01

Attachment of platelets from the circulation onto a growing thrombus is a process involving multiple platelet receptors, endothelial matrix components, and coagulation factors. It has been indicated previously that during a transglutaminase reaction activated factor XIII (FXIIIa) covalently cross-links von Willebrand factor (VWF) to polymerizing fibrin. Bound VWF further recruits and activates platelets via interactions with the platelet receptor complex glycoprotein Ib (GPIb). In the present study we found proof for binding of VWF to a fibrin monomer layer during the process of fibrinogen-to-fibrin conversion in the presence of thrombin, arvin, or a snake venom from Crotalus atrox. Using a domain deletion mutant we demonstrated the involvement of the C domains of VWF in this binding. Substantial binding of VWF to fibrin monomers persisted in the presence of the FXIIIa inhibitor K9-DON, illustrating that cross-linking via factor XIII is not essential for this phenomenon and suggesting the identification of a second mechanism through which VWF multimers incorporate into a fibrin network. Under high shear conditions, platelets were shown to adhere to fibrin only if VWF had been incorporated. In conclusion, our experiments show that the C domains of VWF and the E domain of fibrin monomers are involved in the incorporation of VWF during the polymerization of fibrin and that this incorporation fosters binding and activation of platelets. Fibrin thus is not an inert end product but partakes in further thrombus growth. Our findings help to elucidate the mechanism of thrombus growth and platelet adhesion under conditions of arterial shear rate. PMID:25381443

[Aldose reductase gene polymorphism and rate of appearance of retinopathy in non insulin dependent diabetics].

PubMed

Olmos, P; Acosta, A M; Schiaffino, R; Díaz, R; Alvarado, D; O'Brien, A; Muñoz, X; Arriagada, P; Claro, J C; Vega, R; Vollrath, V; Velasco, S; Emmerich, M; Maiz, A

1999-04-01

Recent studies suggest that polymorphisms associated to the aldose reductase gene could be related to early retinopathy in noninsulin dependent diabetics (NIDDM). There is also new interest on the genetic modulation of coagulation factors in relation to this complication. To look for a possible relationship between the rate of appearance of retinopathy and the genotype of (AC)n polymorphic marker associated to aldose reductase gene. A random sample of 27 NIDDM, aged 68.1 +/- 10.6 years, with a mean diabetes duration of 20.7 +/- 4.8 years and a mean glycosilated hemoglobin of 10.6 +/- 1.6%, was studied. The genotype of the (AC)n, polymorphic marker associated to the 5' end of the aldose reductase (ALR2) gene was determined by 32P-PCR plus sequenciation. Mutations of the factor XIII-A gene were studied by single stranded conformational polymorphism, sequenciation and restriction fragment length polymorphism. Four patients lacked the (AC)24 and had a higher rate of appearance of retinopathy than patients with the (AC)24 allele (0.0167 and 0.0907 score points per year respectively, p = 0.047). Both groups had similar glycosilated hemoglobin (11.7 +/- 0.2 and 10.5 +/- 1.6% respectively). Factor XIII gene mutations were not related to the rate of appearance of retinopathy. Our data suggest that the absence of the (AC)24 allele of the (AC)n polymorphic marker associated to the 5' end of the aldose reductase gene, is associated to a five fold reduction of retinopathy appearance rate.

Safety of recombinant human factor XIII in a cynomolgus monkey model of extracorporeal blood circulation.

PubMed

Ponce, R; Armstrong, K; Andrews, K; Hensler, J; Waggie, K; Heffernan, J; Reynolds, T; Rogge, M

2005-01-01

Factor XIII (FXIII) is a thrombin-activated plasma coagulation factor critical for blood clot stabilization and longevity. Administration of exogenous FXIII to replenish depleted stores after major surgery, including cardiopulmonary bypass, may reduce bleeding complications and transfusion requirements. Thus, a model of extracorporeal circulation (ECC) was developed in adult male cynomolgus monkeys (Macaca fascicularis) to evaluate the nonclinical safety of recombinant human FXIII (rFXIII). The hematological and coagulation profile in study animals during and after 2 h of ECC was similar to that reported for humans during and after cardiopulmonary bypass, including observations of anemia, thrombocytopenia, and activation of coagulation and platelets. Intravenous slow bolus injection of 300 U/kg (2.1 mg/kg) or 1000 U/kg (7 mg/kg) rFXIII after 2 h of ECC was well tolerated in study animals, and was associated with a dose-dependent increase in FXIII activity. No clinically significant effects in respiration, ECG, heart rate, blood pressure, body temperature, clinical chemistry, hematology (including platelet counts), or indicators of thrombosis (thrombin:anti-thrombin complex and D-Dimer) or platelet activation (platelet factor 4 and beta-thromboglobulin) were related to rFXIII administration. Specific examination of brain, heart, lung, liver, and kidney from rFXIII-treated animals provided no evidence of histopathological alterations suggestive of subclinical hemorrhage or thrombosis. Taken as a whole, the results demonstrate the ECC model suitably replicated the clinical presentation reported for humans during and after cardiopulmonary bypass surgery, and do not suggest significant concerns regarding use of rFXIII in replacement therapy after extracorporeal circulation.

Extreme Ultraviolet Emission Lines of Iron Fe XI-XIII

NASA Astrophysics Data System (ADS)

Lepson, Jaan; Beiersdorfer, P.; Brown, G. V.; Liedahl, D. A.; Brickhouse, N. S.; Dupree, A. K.

2013-04-01

The extreme ultraviolet (EUV) spectral region (ca. 20--300 Å) is rich in emission lines from low- to mid-Z ions, particularly from the middle charge states of iron. Many of these emission lines are important diagnostics for astrophysical plasmas, providing information on properties such as elemental abundance, temperature, density, and even magnetic field strength. In recent years, strides have been made to understand the complexity of the atomic levels of the ions that emit the lines that contribute to the richness of the EUV region. Laboratory measurements have been made to verify and benchmark the lines. Here, we present laboratory measurements of Fe XI, Fe XII, and Fe XIII between 40-140 Å. The measurements were made at the Lawrence Livermore electron beam ion trap (EBIT) facility, which has been optimized for laboratory astrophysics, and which allows us to select specific charge states of iron to help line identification. We also present new calculations by the Hebrew University - Lawrence Livermore Atomic Code (HULLAC), which we also utilized for line identification. We found that HULLAC does a creditable job of reproducing the forest of lines we observed in the EBIT spectra, although line positions are in need of adjustment, and line intensities often differed from those observed. We identify or confirm a number of new lines for these charge states. This work was supported by the NASA Solar and Heliospheric Program under Contract NNH10AN31I and the DOE General Plasma Science program. Work was performed in part under the auspices of the Department of Energy by Lawrence Livermore National Laboratory under Contract DEAC52-07NA27344.

Factor XIII stiffens fibrin clots by causing fiber compaction.

PubMed

Kurniawan, N A; Grimbergen, J; Koopman, J; Koenderink, G H

2014-10-01

Factor XIII-induced cross-linking has long been associated with the ability of fibrin blood clots to resist mechanical deformation, but how FXIII can directly modulate clot stiffness is unknown. We hypothesized that FXIII affects the self-assembly of fibrin fibers by altering the lateral association between protofibrils. To test this hypothesis, we studied the cross-linking kinetics and the structural evolution of the fibers and clots during the formation of plasma-derived and recombinant fibrins by using light scattering, and the response of the clots to mechanical stresses by using rheology. We show that the lateral aggregation of fibrin protofibrils initially results in the formation of floppy fibril bundles, which then compact to form tight and more rigid fibers. The first stage is reflected in a fast (10 min) increase in clot stiffness, whereas the compaction phase is characterized by a slow (hours) development of clot stiffness. Inhibition of FXIII completely abrogates the slow compaction. FXIII strongly increases the linear elastic modulus of the clots, but does not affect the non-linear response at large deformations. We propose a multiscale structural model whereby FXIII-mediated cross-linking tightens the coupling between the protofibrils within a fibrin fiber, thus making the fiber stiffer and less porous. At small strains, fiber stiffening enhances clot stiffness, because the clot response is governed by the entropic elasticity of the fibers, but once the clot is sufficiently stressed, the modulus is independent of protofibril coupling, because clot stiffness is governed by individual protofibril stretching. © 2014 International Society on Thrombosis and Haemostasis.

Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice

PubMed Central

Martin, Sara M.; Holle, Lori A.; Cooley, Brian C.; Flick, Matthew J.

2018-01-01

The transglutaminase factor XIII (FXIII) stabilizes clots against mechanical and biochemical disruption and is essential for hemostasis. In vitro and in vivo models of venous thrombosis demonstrate that FXIII mediates clot size by promoting red blood cell (RBC) retention. However, the key source of FXIII and whether FXIII activity can be reduced to suppress thrombosis without imposing deleterious hemostatic consequences are 2 critical unresolved questions. FXIII is present in multiple compartments, including plasma (FXIIIplasma) as a heterotetramer of A2 and B2 subunits and platelets (FXIIIplt) as an A2 homodimer. We determined the role of the FXIII compartment and level in clot contraction, composition, and size in vitro and using in vivo models of hemostasis and venous thrombosis. Reducing overall FXIII levels decreased whole blood clot weight but did not alter thrombin generation or contraction of platelet-rich plasma clots. In reconstituted platelet-rich plasma and whole blood clot contraction assays, FXIIIplasma, but not FXIIIplt, produced high-molecular-weight fibrin crosslinks, promoted RBC retention, and increased clot weights. Genetically imposed reduction of FXIII delayed FXIII activation and fibrin crosslinking, suggesting FXIII levels mediate the kinetics of FXIII activation and activity and that the timing of these processes is a critical determinant of RBC retention during clot formation and contraction. A 50% reduction in FXIIIplasma produced significantly smaller venous thrombi but did not increase bleeding in tail transection or saphenous vein puncture models in vivo. Collectively, these findings suggest that partial FXIII reduction may be a therapeutic strategy for reducing venous thrombosis. PMID:29344582

Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice.

PubMed

Kattula, Sravya; Byrnes, James R; Martin, Sara M; Holle, Lori A; Cooley, Brian C; Flick, Matthew J; Wolberg, Alisa S

2018-01-09

The transglutaminase factor XIII (FXIII) stabilizes clots against mechanical and biochemical disruption and is essential for hemostasis. In vitro and in vivo models of venous thrombosis demonstrate that FXIII mediates clot size by promoting red blood cell (RBC) retention. However, the key source of FXIII and whether FXIII activity can be reduced to suppress thrombosis without imposing deleterious hemostatic consequences are 2 critical unresolved questions. FXIII is present in multiple compartments, including plasma (FXIII plasma ) as a heterotetramer of A 2 and B 2 subunits and platelets (FXIII plt ) as an A 2 homodimer. We determined the role of the FXIII compartment and level in clot contraction, composition, and size in vitro and using in vivo models of hemostasis and venous thrombosis. Reducing overall FXIII levels decreased whole blood clot weight but did not alter thrombin generation or contraction of platelet-rich plasma clots. In reconstituted platelet-rich plasma and whole blood clot contraction assays, FXIII plasma , but not FXIII plt , produced high-molecular-weight fibrin crosslinks, promoted RBC retention, and increased clot weights. Genetically imposed reduction of FXIII delayed FXIII activation and fibrin crosslinking, suggesting FXIII levels mediate the kinetics of FXIII activation and activity and that the timing of these processes is a critical determinant of RBC retention during clot formation and contraction. A 50% reduction in FXIII plasma produced significantly smaller venous thrombi but did not increase bleeding in tail transection or saphenous vein puncture models in vivo. Collectively, these findings suggest that partial FXIII reduction may be a therapeutic strategy for reducing venous thrombosis.

Relative effects of plasma, fibrinogen concentrate, and factor XIII on ROTEM coagulation profiles in an in vitro model of massive transfusion in trauma.

PubMed

Schmidt, David E; Halmin, Märit; Wikman, Agneta; Östlund, Anders; Ågren, Anna

2017-10-01

Massive traumatic haemorrhage is aggravated through the development of trauma-induced coagulopathy, which is managed by plasma transfusion and/or fibrinogen concentrate administration. It is yet unclear whether these treatments are equally potent in ensuring adequate haemostasis, and whether additional factor XIII (FXIII) administration provides further benefits. In this study, we compared ROTEM whole blood coagulation profiles after experimental massive transfusion with different transfusion regimens in an in vitro model of dilution- and transfusion-related coagulopathy. Healthy donor blood was mixed 1 + 1 with six different transfusion regimens. Each regimen contained RBC, platelet concentrate, and either fresh frozen plasma (FFP) or Ringer's acetate (RA). The regimens were further augmented through addition of a low- or medium-dose fibrinogen concentrate and FXIII. Transfusion with FFP alone was insufficient to maintain tissue-factor activated clot strength, coincidental with a deficiency in fibrin-based clot strength. Fibrinogen concentrate conserved, but did not improve coagulation kinetics and overall clot strength. Only combination therapy with FFP and low-dose fibrinogen concentrate improved both coagulation kinetics and fibrin-based clot strength. Administration of FXIII did not result in an improvement of clot strength. In conclusion, combination therapy with both FFP and low-dose fibrinogen concentrate improved clotting time and produced firm clots, representing a possible preferred first-line regimen to manage trauma-induced coagulopathy when RBC and platelets are also transfused. Further research is required to identify optimal first-line transfusion fluids for massive traumatic haemorrhage.

Recombinant Factor XIII Mitigates Hemorrhagic Shock-Induced Organ Dysfunction

PubMed Central

Zaets, Sergey B.; Xu, Da-Zhong; Lu, Qi; Feketova, Eleonora; Berezina, Tamara L.; Malinina, Inga V.; Deitch, Edwin A.; Olsen, Eva H.

2012-01-01

Background Plasma factor XIII (FXIII) is responsible for stabilization of fibrin clot at the final stage of blood coagulation. Since FXIII has also been shown to modulate inflammation, endothelial permeability, as well as diminish multiple organ dysfunction (MOD) after gut ischemia-reperfusion injury, we hypothesized that FXIII would reduce MOD caused by trauma-hemorrhagic shock (THS). Materials and methods Rats were subjected to a 90 min THS or trauma sham shock (TSS) and treated with either recombinant human FXIII A2 subunit (rFXIII) or placebo immediately after resuscitation with shed blood or at the end of the TSS period. Lung permeability, lung and gut myeloperoxidase (MPO) activity, gut histology, neutrophil respiratory burst, microvascular blood flow in the liver and muscles, and cytokine levels were measured 3 h after the THS or TSS. FXIII levels were measured before THS or TSS and after the 3-h post-shock period. Results THS-induced lung permeability as well as lung and gut MPO activity was significantly lower in rFXIII-treated than in placebo-treated animals. Similarly, rFXIII-treated rats had lower neutrophil respiratory burst activity and less ileal mucosal injury. rFXIII-treated rats also had a higher liver microvascular blood flow compared with the placebo group. Cytokine response was more favorable in rFXIII-treated animals. Trauma-hemorrhagic shock did not cause a drop in FXIII activity during the study period. Conclusions Administration of rFXIII diminishes THS-induced MOD in rats, presumably by preservation of the gut barrier function, limitation of polymorphonuclear leukocyte (PMN) activation, and modulation of the cytokine response. PMID:21276979

RECOMBINANT FACTOR XIII DIMINISHES MULTIPLE ORGAN DYSFUNCTION IN RATS CAUSED BY GUT ISCHEMIA-REPERFUSION INJURY

PubMed Central

Zaets, Sergey B.; Xu, Da-Zhong; Lu, Qi; Feketova, Eleonora; Berezina, Tamara L.; Gruda, Maryann; Malinina, Inga V.; Deitch, Edwin A.; Olsen, Eva H. N.

2010-01-01

Plasma factor XIII (FXIII) is responsible for stabilization of fibrin clot at the final stage of blood coagulation. Because FXIII has also been shown to modulate inflammation and endothelial permeability, we hypothesized that FXIII diminishes multiple organ dysfunction caused by gut I/R injury. A model of superior mesenteric artery occlusion (SMAO) was used to induce gut I/R injury. Rats were subjected to 45-min SMAO or sham SMAO and treated with recombinant human FXIII A2 subunit (rFXIII) or placebo at the beginning of the reperfusion period. Lung permeability, lung and gut myeloperoxidase activity, gut histology, neutrophil respiratory burst, and microvascular blood flow in the liver and muscles were measured after a 3-h reperfusion period. The effect of activated rFXIII on transendothelial resistance of human umbilical vein endothelial cells was tested in vitro. Superior mesenteric artery occlusion–induced lung permeability as well as lung and gut myeloperoxidase activity was significantly lower in rFXIII-treated versus untreated animals. Similarly, rFXIII-treated rats had lower neutrophil respiratory burst activity and ileal mucosal injury. Rats treated with rFXIII also had higher liver microvascular blood flow compared with the placebo group. Superior mesenteric artery occlusion did not cause FXIII consumption during the study period. In vitro, activated rFXIII caused a dose-dependent increase in human umbilical vein endothelial cell monolayer resistance to thrombin-induced injury. Thus, administration of rFXIII diminishes SMAO-induced multiple organ dysfunction in rats, presumably by preservation of endothelial barrier function and the limitation of polymorphonuclear leukocyte activation. PMID:18948851

Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.

PubMed

Temperini, Claudia; Cecchi, Alessandro; Scozzafava, Andrea; Supuran, Claudiu T

2009-02-01

Thiazide and high ceiling diuretics were recently shown to inhibit all mammalian isoforms of carbonic anhydrase (CA, EC 4.2.1.1) with a very different profile as compared to classical inhibitors, such as acetazolamide, methazolamide, and ethoxzolamide. Some of these structurally related compounds have a very different behavior against the widespread isozyme CA II, with chlorthalidone, trichloromethiazide, and furosemide being efficient inhibitors against CA II (K(I)s of 65-138 nM), whereas indapamide is a much weaker one (K(I) of 2520 nM). Furthermore, some of these diuretics are quite efficient (low nanomolar) inhibitors of other isoforms, for example, chlorthalidone against hCA VB, VII, IX, and XIII; indapamide against CA VII, IX, XII, and XIII, trichloromethiazide against CA VII and IX, and furosemide against CA I and XIV. Examining the four X-ray crystal structures of their CA II adducts, we observed several (2-3) active site water molecules interacting with the chlorthalidone, trichloromethiazide, and furosemide scaffolds which may be responsible for this important difference of activity. Indeed, indapamide bound to CA II has no interactions with active site water molecules. Chlorthalidone bound within the CA II active site is in an enolic (lactimic) tautomeric form, with the enolic OH also participating in two strong hydrogen bonds with Asn67 and a water molecule. The newly evidenced binding modes of these diuretics may be exploited for designing better CA II inhibitors as well as compounds with selectivity/affinity for various isoforms with medicinal chemistry applications.

Factor XIII Val34Leu polymorphism and the risk of myocardial infarction under the age of 36 years.

PubMed

Rallidis, Loukianos S; Politou, Marianna; Komporozos, Christoforos; Panagiotakos, Demosthenes B; Belessi, Chrisoula I; Travlou, Anthi; Lekakis, John; Kremastinos, Dimitrios T

2008-06-01

There are limited and controversial data regarding the impact of factor XIII (FXIII) Val34Leu polymorphism in the pathogenesis of premature myocardial infarction (MI). We examined whether FXIII Val34Leu polymorphism is associated with the development of early MI. We recruited 159 consecutive patients who had survived their first acute MI under the age of 36 years (mean age = 32.1 +/- 3.6 years, 138 were men). The control group consisted of 121 healthy individuals matched with cases for age and sex, without a family history of premature coronary heart disease (CHD). FXIII Val34Leu polymorphism was tested with polymerase chain reaction and reverse hybridization. There was a lower prevalence of carriers of the Leu34 allele in patients than in controls (30.2 vs. 47.1%, p = 0.006). FXIII Val34Leu polymorphism was associated with lower risk for acute MI after adjusting for major cardiovascular risk factors (odds ratio [OR] = 0.51, 95% confidence interval [CI] 0.27-0.95, p = 0.03). Subgroup analysis according to angiographic findings ("normal" coronary arteries [n = 29] or significant CHD [n = 130]) showed that only patients with MI and significant CHD had lower prevalence of carriers of the Leu34 allele compared to controls after adjusting for major cardiovascular risk factors (OR = 0.42, 95% CI 0.22-0.83, p = 0.01). Our data indicate that FXIII Val34Leu polymorphism has a protective effect against the development of MI under the age of 36 years, particularly in the setting of significant CHD.

Modifications to the NIST reference measurement procedure (RMP) for the determination of serum glucose by isotope dilution gas chromatography/mass spectrometry.

PubMed

Prendergast, Jocelyn L; Sniegoski, Lorna T; Welch, Michael J; Phinney, Karen W

2010-07-01

The definitive method (DM), now known as the reference measurement procedure (RMP), for the analysis of glucose in serum was originally published in 1982 by the National Institute of Standards and Technology (NIST). Over the years the method has been subject to a number of modifications to adapt to newer technologies and simplify sample preparation. We discuss here an adaptation of the method associated with serum glucose measurements using a modified isotope dilution gas chromatography/mass spectrometry (ID-GC/MS) method. NIST has used this modified method to certify the concentrations of glucose in SRM 965b, Glucose in Frozen Human Serum, and SRM 1950, Metabolites in Human Plasma. Comparison of results from the revised method with certified values for existing Standard Reference Materials (SRMs) demonstrated that these modifications have not affected the quality of the measurements, giving both good precision and accuracy, while reducing the sample preparation time by a day and a half.

Assessment of SEPS solar array technology for orbital service module application

NASA Technical Reports Server (NTRS)

1978-01-01

Work performed in the following assessment areas on the SEPS solar array is reported: (1) requirements definition, (2) electrical design evaluation, (3) mechanical design evaluation, and (4) design modification analysis. General overall assessment conclusions are summarized. There are no known serious design limitations involved in the implementation of the recommended design modifications. A section of orbiter and array engineering drawings is included.

Genome-scale engineering for systems and synthetic biology

PubMed Central

Esvelt, Kevin M; Wang, Harris H

2013-01-01

Genome-modification technologies enable the rational engineering and perturbation of biological systems. Historically, these methods have been limited to gene insertions or mutations at random or at a few pre-defined locations across the genome. The handful of methods capable of targeted gene editing suffered from low efficiencies, significant labor costs, or both. Recent advances have dramatically expanded our ability to engineer cells in a directed and combinatorial manner. Here, we review current technologies and methodologies for genome-scale engineering, discuss the prospects for extending efficient genome modification to new hosts, and explore the implications of continued advances toward the development of flexibly programmable chasses, novel biochemistries, and safer organismal and ecological engineering. PMID:23340847

Development of a Flow Field for Testing a Boundary-Layer-Ingesting Propulsor

NASA Technical Reports Server (NTRS)

Hirt, Stefanie M.; Arend, David J.; Wolter, John D.; Johnson, Aaron

2017-01-01

In order to test embedded-propulsor technology, modifications were required of the 8x6 Supersonic Wind tunnel at NASA Glenn Research Center. The extent of the modifications required that a new tunnel calibration be completed to generate a new calibration dataset and operational procedures for the tunnel, as well as to map the boundary layer on the raised floor. This report describes the propulsor inflow that was to be simulated, documents the tunnel modifications that were required, and conveys the results of the calibration test that was completed to measure the resulting flow properties.

Research pressure instrumentation for NASA Space Shuttle main engine, modification no. 5

NASA Technical Reports Server (NTRS)

Anderson, P. J.; Nussbaum, P.; Gustafson, G.

1984-01-01

The purpose of Modification No. 5 of this contract is to expand the scope of work (Task C) of this research study effort to develop pressure instrumentation for the SSME. The objective of this contract (Task C) is to direct Honeywell's Solid State Electronics Division's (SSED) extensive experience and expertise in solid state sensor technology to develop prototype pressure transducers which are targeted to meet the SSME performance design goals and to fabricate, test and deliver a total of 10 prototype units. SSED's basic approach is to effectively utilize the many advantages of silicon piezoresistive strain sensing technology to achieve the objectives of advanced state-of-the-art pressure sensors in terms of reliability, accuracy and ease of manufacture. More specifically, integration of multiple functions on a single chip is the key attribute of this technology which will be exploited during this research study.

A Review of Ultrafiltration and Forward Osmosis:application and modification

NASA Astrophysics Data System (ADS)

Chao, Gong; Shuili, Yu; Yufei, Shangguan; Zhengyang, Gu; Wangzhen, Yang; Liumo, Ren

2018-03-01

As a new treatment, membrane filtration is playing a more prominent role in treating many kinds of wastewater. Among all the membrane technologies, ultrafiltration(UF) and forward osmosis(FO) technology has been widely utilized and developed in oil field and refinery produced water. However, the reports about the differences between the two kinds of membrane technology used in oily wastewater are not yet available. In this review, at first we introduce the advantages, shortcomings and applications of UF and FO membranes. Among these, we mainly illustrate the membrane fouling, which now is a big problem because it increases costs and decreases membrane life to limit the industrialization of the membrane, and the different modification methods of membranes are discussed to figure out how these ways can ease the membrane fouling. Next we make a comparison of the two membranes. Finally we illustrate the future research topics.

Fingerprinting of music scores

NASA Astrophysics Data System (ADS)

Irons, Jonathan; Schmucker, Martin

2004-06-01

Publishers of sheet music are generally reluctant in distributing their content via the Internet. Although online sheet music distribution's advantages are numerous the potential risk of Intellectual Property Rights (IPR) infringement, e.g. illegal online distributions, disables any innovation propensity. While active protection techniques only deter external risk factors, additional technology is necessary to adequately treat further risk factors. For several media types including music scores watermarking technology has been developed, which ebeds information in data by suitable data modifications. Furthermore, fingerprinting or perceptual hasing methods have been developed and are being applied especially for audio. These methods allow the identification of content without prior modifications. In this article we motivate the development of watermarking and fingerprinting technologies for sheet music. Outgoing from potential limitations of watermarking methods we explain why fingerprinting methods are important for sheet music and address potential applications. Finally we introduce a condept for fingerprinting of sheet music.

Emerging technologies for studying DNA methylation for the molecular diagnosis of cancer

PubMed Central

Marzese, Diego M.; Hoon, Dave S.B.

2015-01-01

DNA methylation is an epigenetic mechanism that plays a key role in regulating gene expression and other functions. Although this modification is seen in different sequence contexts, the most frequently detected DNA methylation in mammals involves cytosine-guanine dinucleotides. Pathological alterations in DNA methylation patterns are described in a variety of human diseases, including cancer. Unlike genetic changes, DNA methylation is heavily influenced by subtle modifications in the cellular microenvironment. In all cancers, aberrant DNA methylation is involved in the alteration of a large number of oncological pathways with relevant theranostic utility. Several technologies for DNA methylation mapping were recently developed and successfully applied in cancer studies. The scope of these technologies varies from assessing a single cytosine-guanine locus to genome-wide distribution of DNA methylation. Here, we review the strengths and weaknesses of these approaches in the context of clinical utility for the molecular diagnosis of human cancers. PMID:25797072

Reform in Undergraduate Science, Technology, Engineering, and Mathematics: The Classroom Context

ERIC Educational Resources Information Center

Stage, Frances K.; Kinzie, Jillian

2009-01-01

This article reports the results of a series of site visits examining modifications to science, technology, engineering, and mathematics (STEM) teaching and learning based on reform on three differing campuses. Innovations in stem classrooms included collaborative approaches to learning; incorporation of active learning, authentic contexts, peer…

Getting Results: Small Changes, Big Cohorts and Technology

ERIC Educational Resources Information Center

Kenney, Jacqueline L.

2012-01-01

This paper presents an example of constructive alignment in practice. Integrated technology supports were deployed to increase the consistency between learning objectives, activities and assessment and to foster student-centred, higher-order learning processes in the unit. Modifications took place over nine iterations of a second-year Marketing…

Decoding ClassDojo: Psycho-Policy, Social-Emotional Learning and Persuasive Educational Technologies

ERIC Educational Resources Information Center

Williamson, Ben

2017-01-01

ClassDojo is one of the world's most successful educational technologies, currently used by over 3 million teachers and 35 million children globally. It reinforces and enacts emerging governmental "psycho-policies" around the measurement and modification of children's social and emotional learning in schools. This article focuses…

New or Novice Teacher Integration of Mobile Learning Instruction

ERIC Educational Resources Information Center

Beisel, Carolyn Anne

2017-01-01

The substitution, augmentation, modification, and redefinition (SAMR) model is designed to help teachers integrate technology in the classroom. In a district with 1:1 mobile technology, teachers expressed frustration and inconsistency about the use the SAMR model for effective teaching and learning. In this project study, the SAMR model…

77 FR 23753 - Certain Ink Cartridges and Components Thereof; Modification of Remedial Orders and Termination of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-20

... cartridges. On December 13, 2010, two respondents in the underlying investigation, Ninestar Technology Co., Ltd. and Ninestar Technology Company, Ltd. (``Ninestar U.S.'') (collectively, ``Ninestar''), filed a... order and cease and desist orders. The Commission named as respondents 24 companies located in China...

Modification of Instructional Delivery and Student Learning with the Use of Educational Technologies

ERIC Educational Resources Information Center

Rogers, Jeffrey Ray

2012-01-01

The purpose of this study was to determine if educational technologies, including LCD projectors, interactive whiteboards, tablets, document cameras, and student response systems, modify instructional delivery and student learning. This case study was researched in four classrooms, including an English, math, science and social studies classroom…

76 FR 46678 - Tris carbamoyl triazine; Proposed Modification of Significant New Uses

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-03

.... During the initial review of the PMN, EPA's preliminary Ecological Structural Activity Relationship (Eco... Executive Order 12866. I. National Technology Transfer and Advancement Act In addition, since this action does not involve any technical standards, section 12(d) of the National Technology Transfer and...

TOPICAL REVIEW: Surface modification and characterization for dispersion stability of inorganic nanometer-scaled particles in liquid media

NASA Astrophysics Data System (ADS)

Kamiya, Hidehiro; Iijima, Motoyuki

2010-08-01

Inorganic nanoparticles are indispensable for science and technology as materials, pigments and cosmetics products. Improving the dispersion stability of nanoparticles in various liquids is essential for those applications. In this review, we discuss why it is difficult to control the stability of nanoparticles in liquids. We also overview the role of surface interaction between nanoparticles in their dispersion and characterization, e.g. by colloid probe atomic force microscopy (CP-AFM). Two types of surface modification concepts, post-synthesis and in situ modification, were investigated in many previous studies. Here, we focus on post-synthesis modification using adsorption of various kinds of polymer dispersants and surfactants on the particle surface, as well as surface chemical reactions of silane coupling agents. We discuss CP-AFM as a technique to analyze the surface interaction between nanoparticles and the effect of surface modification on the nanoparticle dispersion in liquids.

[Genome editing of industrial microorganism].

PubMed

Zhu, Linjiang; Li, Qi

2015-03-01

Genome editing is defined as highly-effective and precise modification of cellular genome in a large scale. In recent years, such genome-editing methods have been rapidly developed in the field of industrial strain improvement. The quickly-updating methods thoroughly change the old mode of inefficient genetic modification, which is "one modification, one selection marker, and one target site". Highly-effective modification mode in genome editing have been developed including simultaneous modification of multiplex genes, highly-effective insertion, replacement, and deletion of target genes in the genome scale, cut-paste of a large DNA fragment. These new tools for microbial genome editing will certainly be applied widely, and increase the efficiency of industrial strain improvement, and promote the revolution of traditional fermentation industry and rapid development of novel industrial biotechnology like production of biofuel and biomaterial. The technological principle of these genome-editing methods and their applications were summarized in this review, which can benefit engineering and construction of industrial microorganism.

Migraine and genetic polymorphisms: an overview.

PubMed

Pizza, Vincenzo; Agresta, Anella; Agresta, Antonio; Lamaida, Eros; Lamaida, Norman; Infante, Francesco; Capasso, Anna

2012-01-01

The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in vascular diseases related to migraine. The present review analyzes both the incidence of the above genetic vascular mutations in migraineurs and the most re-cent developments related to genetic polymorphisms and migraine.

Migraine and Genetic Polymorphisms: An Overview

PubMed Central

Pizza, Vincenzo; Agresta, Anella; Agresta, Antonio; Lamaida, Eros; Lamaida, Norman; Infante, Francesco; Capasso, Anna

2012-01-01

The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in vascular diseases related to migraine. The present review analyzes both the incidence of the above genetic vascular mutations in migraineurs and the most re-cent developments related to genetic polymorphisms and migraine. PMID:22962564

Providing for consideration of the joint resolution (H.J. Res. 75) making continuing appropriations for the Special Supplemental Nutrition Program for Women, Infants, and Children for fiscal year 2014, and for other purposes; providing for consideration of motions to suspend the rules; waiving a requirement of clause 6(a) of rule XIII with respect to consideration of certain resolutions reported from the Committee on Rules; and for other purposes.

THOMAS, 113th Congress

Rep. Cole, Tom [R-OK-4

2013-10-03

House - 10/04/2013 On agreeing to the Cole amendment (A001) Agreed to without objection. (All Actions) Tracker: This bill has the status Agreed to in HouseHere are the steps for Status of Legislation:

Properties of II-VI Semiconductors: Bulk Crystals, Epitaxial Films, Quantum Well Structures, and Dilute Magnetic Systems. Materials Research Society Symposium Proceedings. Volume 161

DTIC Science & Technology

1990-11-21

1989, ISBN 1-55899-063-1 Volume 176-Scientific Basis for Nuclear Waste Management XIII, V.M. Oversby, P.W. Brown, 1989, ISBN 1-55899-064-X Volume 177...J.M. PePUYDT, H. CHENG, M.A. HAASE AND J.E. POTTS 3M Company, 201-1N-35 / 3M Center, St. Paul , MN 55144. Recently, with the advent of thermal...their small business innovative research program. The authors wish to thank Larry Knight, director of the Center for X-ray Imaging at Brigham Young

Toward a Theory of Hybrid Warfare: The Russian Conduct of War During Peace

DTIC Science & Technology

2015-12-01

PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME(S) AND ADDRESS(ES) N /A 10. SPONSORING / MONITORING AGENCY REPORT...See also: Edward N . Luttwak, “Notes on Low-Intensity Warfare,” Parameters XIII, no.4 (Carlisle Barracks, PA; U.S. Army War College, 1983...the Russian interview titled: И.Стрелков Vs Н.Стариков “ЦЕНТРСИЛЫ / СИЛАЦЕНТРА” [I. Strelkov vs. N . Starikov “CENTRSILY/ SILACENTRA”], aired

Studies of Brazilian meteorites. XIII - Mineralogy, petrology, and chemistry of the Putinga, Rio Grande do Sul, chondrite

NASA Technical Reports Server (NTRS)

Keil, K.; Lange, D.; Ulbrich, M. N. C.; Gomes, C. B.; Jarosewich, E.; Roisenberg, A.; Souza, M. J.

1978-01-01

The Putinga, Rio Grande do Sul chondrite is described and classified as an L6. The mineral composition and some significant ratios of elements are reported, and the reasons for assignment to the L group and to petrologic type 6 are explained. The analysis suggests that maskelynite of oligoclase composition was formed by solid-state shock transformation of previously existing well-crystallized plagioclase at estimated shock pressures of about 250-350 kbar. This finding indicates that recrystallization (formation of well-crystallized oligoclase) preceded shock transformation formation of the maskelynite.

Medical Entomology Studies - XIII. The Myzomyia Series of Anopheles (Cellia) in Thailand, with Emphasis on Intra-Interspecific Variations (Diptera: Culicidae) (Contributions of the American Entomological Institute. Volume 17, Number 4, 1980)

DTIC Science & Technology

1980-01-01

pinpoint the collection site as Fang District, Chiang Mai Province in June 1952. However, no specimens confirming the record have been found in the...members of the Myzomyia Series in Thailand were in Barnes (1923a, b), who recorded aconitus from Bangkok and Chiang Mai , culicifacies from Chiang Mai , fluviatilis...as funestus Giles, = listoni Liston) from Bangkok and Chiang Mai and minimus from Bangkok. Barnes (1923b) also contained a key to the

Two radiation-induced chromosomal inversions in mice (Mus musculus).

PubMed

Roderick, T H; Hawes, N L

1970-10-01

Whole-body x-irradiation of male mice has produced presumptive paracentric inversions in 15 animals, as evidenced by high frequencies of first meiotic anaphase bridges. Two of the highest frequencies observed have been propagated through several generations and found to behave as dominant genes. Acentric fragments were observed associated with about 10% of the bridges. The first inversion, in linkage group XIII, has been designated In(13)1Rk, and the second, in linkage group XVII, In(17)2Rk. For In(13)1Rk, recombination was reduced between loci inside and outside the inverted segment.

The VELA Program. A Twenty-Five Year Review of Basic Research

DTIC Science & Technology

1985-01-01

Z7 - db -gP W- -~ g F 7 f. -t-4? - Un~imue h 9 * so :;-. 6 do. 0AAA3LO C Best Available Copy I@ The VELA Program A Twenty-Five Vear Review of Basic...Modeling in the Inelastic Region of Underground Nuclear Explosions L.I. Burdick, I.S. Barker, D. V. Helmbewr, and D. G . Harkridff 130 Spall Contribution to...Contas Xiii In-Situ Strain Paths and Stress Bounds with Application to Desert Alit iviutm. JG. Truio 344 Model ",- g L. Codas of P-SV and SH by Vertical

Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3.

PubMed

Schmid, Evi; Yan, Jing; Nurbaeva, Meerim K; Russo, Antonella; Yang, Wenting; Faggio, Caterina; Shumilina, Ekaterina; Lang, Florian

2014-01-01

Dendritic cells (DCs), key players of immunity, are regulated by glycogen synthase kinase GSK3. GSK3 activity is suppressed by PKB/Akt and SGK isoforms, which are in turn stimulated by the PI3K pathway. Exposure to bacterial lipopolysaccharides increases cytosolic Ca(2+)-concentration ([Ca(2+)]i), an effect augmented in DCs isolated from mutant mice expressing PKB/SGK-resistant GSK3α,β (gsk3(KI) ). Factors affecting [Ca(2+)]i include Ca(2+)-release from intracellular stores (CRIS), store-operated Ca(2+)-entry (SOCE) through STIM1/STIM2-regulated Orai1, K(+)-dependent Na(+)/Ca(2+)-exchangers (NCKX), K(+)-independent Na(+)/Ca(2+)-exchangers (NCX) and calbindin-D28k. The present study explored whether PKB/SGK-dependent GSK3α, β-activity impacts on CRIS, SOCE, NCKX, NCX or calbindin. DCs were isolated from gsk3(KI) mice and respective wild-type mice (gsk3(WT) ), [Ca(2+)]i estimated from Fura2 fluorescence, Orai1, STIM1, STIM2 as well as calbindin-D28k protein abundance determined by Western blotting and mRNA levels quantified by real time PCR. As a result, thapsigargin-induced CRIS and SOCE were significantly blunted by GSK3-inhibitors SB216763 (1-10 µM, 30 min) or GSK-XIII (10 µM, 30 min) but were significantly lower in gsk3(WT) than in gsk3(KI) DCs. Orai1, STIM1 and STIM2 protein abundance was significantly lower and calbindin-D28k abundance significantly higher in gsk3(KI) than in gsk3(WT) DCs. Activity of NCKX and NCX was significantly higher in gsk3(KI) than in gsk3(WT) DCs and was significantly increased by SB216763 (1 µM, 30 min) or GSK-XIII (10 µM, 30 min). Treatment of gsk3(WT) DCs with SB216763 (1 µM, 4-24 h) or GSK-XIII (10 µM, 4-24 h) did not significantly modify the protein abundance of Orai1, STIM1 and STIM2. The present observations point to a dual role of GSK3 in the regulation of Ca(2+) in DCs. Acute inhibition of GSK3 blunted the increase of [Ca(2+)]i following CRIS and SOCE and stimulated NCKX/NCX activity. However, expression of PKB/SGK-resistant GSK3α, β downregulated the increase of [Ca(2+)]i following CRIS and SOCE, an effect at least partially due to downregulation of Orai1, STIM1 and STIM2 expression as well as upregulation of Na(+)/Ca(2+)-exchanger activity and calbindin D28k expression.

Decreased Store Operated Ca2+ Entry in Dendritic Cells Isolated from Mice Expressing PKB/SGK-Resistant GSK3

PubMed Central

Nurbaeva, Meerim K.; Russo, Antonella; Yang, Wenting; Faggio, Caterina; Shumilina, Ekaterina; Lang, Florian

2014-01-01

Dendritic cells (DCs), key players of immunity, are regulated by glycogen synthase kinase GSK3. GSK3 activity is suppressed by PKB/Akt and SGK isoforms, which are in turn stimulated by the PI3K pathway. Exposure to bacterial lipopolysaccharides increases cytosolic Ca2+-concentration ([Ca2+]i), an effect augmented in DCs isolated from mutant mice expressing PKB/SGK-resistant GSK3α,β (gsk3KI). Factors affecting [Ca2+]i include Ca2+-release from intracellular stores (CRIS), store-operated Ca2+-entry (SOCE) through STIM1/STIM2-regulated Orai1, K+-dependent Na+/Ca2+-exchangers (NCKX), K+-independent Na+/Ca2+-exchangers (NCX) and calbindin-D28k. The present study explored whether PKB/SGK-dependent GSK3α, β-activity impacts on CRIS, SOCE, NCKX, NCX or calbindin. DCs were isolated from gsk3KI mice and respective wild-type mice (gsk3WT), [Ca2+]i estimated from Fura2 fluorescence, Orai1, STIM1, STIM2 as well as calbindin-D28k protein abundance determined by Western blotting and mRNA levels quantified by real time PCR. As a result, thapsigargin-induced CRIS and SOCE were significantly blunted by GSK3-inhibitors SB216763 (1–10 µM, 30 min) or GSK-XIII (10 µM, 30 min) but were significantly lower in gsk3WT than in gsk3KIDCs. Orai1, STIM1 and STIM2 protein abundance was significantly lower and calbindin-D28k abundance significantly higher in gsk3KI than in gsk3WTDCs. Activity of NCKX and NCX was significantly higher in gsk3KI than in gsk3WTDCs and was significantly increased by SB216763 (1 µM, 30 min) or GSK-XIII (10 µM, 30 min). Treatment of gsk3WT DCs with SB216763 (1 µM, 4–24 h) or GSK-XIII (10 µM, 4–24 h) did not significantly modify the protein abundance of Orai1, STIM1 and STIM2. The present observations point to a dual role of GSK3 in the regulation of Ca2+ in DCs. Acute inhibition of GSK3 blunted the increase of [Ca2+]i following CRIS and SOCE and stimulated NCKX/NCX activity. However, expression of PKB/SGK-resistant GSK3α, β downregulated the increase of [Ca2+]i following CRIS and SOCE, an effect at least partially due to downregulation of Orai1, STIM1 and STIM2 expression as well as upregulation of Na+/Ca2+-exchanger activity and calbindin D28k expression. PMID:24523925

Chromospheric evaporation flows and density changes deduced from Hinode/EIS during an M1.6 flare

NASA Astrophysics Data System (ADS)

Gömöry, P.; Veronig, A. M.; Su, Y.; Temmer, M.; Thalmann, J. K.

2016-04-01

Aims: We study the response of the solar atmosphere during a GOES M1.6 flare using spectroscopic and imaging observations. In particular, we examine the evolution of the mass flows and electron density together with the energy input derived from hard X-ray (HXR) in the context of chromospheric evaporation. Methods: We analyzed high-cadence sit-and-stare observations acquired with the Hinode/EIS spectrometer in the Fe xiii 202.044 Å (log T = 6.2) and Fe xvi 262.980 Å (log T = 6.4) spectral lines to derive temporal variations of the line intensity, Doppler shifts, and electron density during the flare. We combined these data with HXR measurements acquired with RHESSI to derive the energy input to the lower atmosphere by flare-accelerated electrons. Results: During the flare impulsive phase, we observe no significant flows in the cooler Fe xiii line but strong upflows, up to 80-150 km s-1, in the hotter Fe xvi line. The largest Doppler shifts observed in the Fe xvi line were co-temporal with the sharp intensity peak. The electron density obtained from a Fe xiii line pair ratio exhibited fast increase (within two minutes) from the pre-flare level of 5.01 × 109 cm-3 to 3.16 × 1010 cm-3 during the flare peak. The nonthermal energy flux density deposited from the coronal acceleration site to the lower atmospheric layers during the flare peak was found to be 1.34 × 1010 erg s-1 cm-2 for a low-energy cut-off that was estimated to be 16 keV. During the decline flare phase, we found a secondary intensity and density peak of lower amplitude that was preceded by upflows of ~15 km s-1 that were detected in both lines. The flare was also accompanied by a filament eruption that was partly captured by the EIS observations. We derived Doppler velocities of 250-300 km s-1 for the upflowing filament material. Conclusions: The spectroscopic results for the flare peak are consistent with the scenario of explosive chromospheric evaporation, although a comparatively low value of the nonthermal energy flux density was determined for this phase of the flare. This outcome is discussed in the context of recent hydrodynamic simulations. It provides observational evidence that the response of the atmospheric plasma strongly depends on the properties of the electron beams responsible for the heating, in particular the steepness of the energy distribution. The secondary peak of line intensity and electron density detected during the decline phase is interpreted as a signature of flare loops being filled by expanding hot material that is due to chromospheric evaporation. A movie is available at http://www.aanda.org

Emissions control for ground power gas turbines

NASA Technical Reports Server (NTRS)

Rudney, R. A.; Priem, R. J.; Juhasz, A. J.; Anderson, D. N.; Mroz, T. S.; Mularz, E. J.

1977-01-01

The similarities and differences of emissions reduction technology for aircraft and ground power gas turbines is described. The capability of this technology to reduce ground power emissions to meet existing and proposed emissions standards is presented and discussed. Those areas where the developing aircraft gas turbine technology may have direct application to ground power and those areas where the needed technology may be unique to the ground power mission are pointed out. Emissions reduction technology varying from simple combustor modifications to the use of advanced combustor concepts, such as catalysis, is described and discussed.

An MRM-based workflow for absolute quantitation of lysine-acetylated metabolic enzymes in mouse liver.

PubMed

Xu, Leilei; Wang, Fang; Xu, Ying; Wang, Yi; Zhang, Cuiping; Qin, Xue; Yu, Hongxiu; Yang, Pengyuan

2015-12-07

As a key post-translational modification mechanism, protein acetylation plays critical roles in regulating and/or coordinating cell metabolism. Acetylation is a prevalent modification process in enzymes. Protein acetylation modification occurs in sub-stoichiometric amounts; therefore extracting biologically meaningful information from these acetylation sites requires an adaptable, sensitive, specific, and robust method for their quantification. In this work, we combine immunoassays and multiple reaction monitoring-mass spectrometry (MRM-MS) technology to develop an absolute quantification for acetylation modification. With this hybrid method, we quantified the acetylation level of metabolic enzymes, which could demonstrate the regulatory mechanisms of the studied enzymes. The development of this quantitative workflow is a pivotal step for advancing our knowledge and understanding of the regulatory effects of protein acetylation in physiology and pathophysiology.

Armaments Coproduction at a Crossroads. U.S. Policy Options After the Cold War.

DTIC Science & Technology

1993-04-01

Copro: $200 million ($132 million R&D; $68 million production) P Technology flowback : - -12 ECPs from NATO, I adopted by U.S. (rotary pump for...and future competition in the global defense marketplace. 0 Standard provisions for royalty-free technology flowback of all design changes...modifications, and improvements. -Some benefits in technology flowback reported by General Dynamics in learning Swiss digital system checkout techniques with

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bates, Robert; McConnell, Elizabeth

Machining methods across many industries generally require multiple operations to machine and process advanced materials, features with micron precision, and complex shapes. The resulting multiple machining platforms can significantly affect manufacturing cycle time and the precision of the final parts, with a resultant increase in cost and energy consumption. Ultrafast lasers represent a transformative and disruptive technology that removes material with micron precision and in a single step manufacturing process. Such precision results from athermal ablation without modification or damage to the remaining material which is the key differentiator between ultrafast laser technologies and traditional laser technologies or mechanical processes.more » Athermal ablation without modification or damage to the material eliminates post-processing or multiple manufacturing steps. Combined with the appropriate technology to control the motion of the work piece, ultrafast lasers are excellent candidates to provide breakthrough machining capability for difficult-to-machine materials. At the project onset in early 2012, the project team recognized that substantial effort was necessary to improve the application of ultrafast laser and precise motion control technologies (for micromachining difficult-to-machine materials) to further the aggregate throughput and yield improvements over conventional machining methods. The project described in this report advanced these leading-edge technologies thru the development and verification of two platforms: a hybrid enhanced laser chassis and a multi-application testbed.« less

Using Fly-By-Wire Technology in Future Models of the UH-60 and Other Rotary Wing Aircraft

NASA Technical Reports Server (NTRS)

Solem, Courtney K.

2011-01-01

Several fixed-winged airplanes have successfully used fly-by-wire (FBW) technology for the last 40 years. This technology is now beginning to be incorporated into rotary wing aircraft. By using FBW technology, manufacturers are expecting to improve upon the weight, maintenance time and costs, handling and reliability of the aircraft. Before mass production of this new system begins in new models such as the UH-60MU, testing must be conducted to insure the safety of this technology as well as to reassure others it will be worth the time and money to make such a dramatic change to a perfectly functional machine. The RASCAL JUH-60A has been modified for these purposes. This Black Hawk helicopter has already been equipped with the FBW technology and can be configured as a near perfect representation of the UH-60MU. Because both machines have very similar qualities, the data collected from the RASCAL can be used to make future decisions about the UH-60MU. The U.S. Army AFDD Flight Project Office oversees all the design modifications for every hardware system used in the RASCAL aircraft. This project deals with specific designs and analyses of unique RASCAL aircraft subsystems and their modifications to conduct flight mechanics research.

The 1987 Goddard Space Flight Center Battery Workshop

NASA Technical Reports Server (NTRS)

Morrow, George (Editor); Yi, Thomas Y. (Editor)

1993-01-01

This document contains the proceedings of the 20th annual Battery Workshop held at Goddard Space Flight Center, Greenbelt, Maryland on November 4-5, 1987. The workshop attendees included manufacturers, users, and government representatives interested in the latest developments in battery technology as they relate to high reliability operations and aerospace use. The subjects covered included lithium cell technology and safety improvements, nickel-cadmium electrode technology along with associated modifications, flight experience and life testing of nickel-cadmium cells, and nickel-hydrogen applications and technology.

77 FR 35870 - Approval of Air Quality Implementation Plans; Wisconsin; Partial Disapproval of “Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... alignment of the State and Federal definition for ``major modification'' occurs as expeditiously as possible... disapproves a state rule implementing a Federal Standard. National Technology Transfer Advancement Act In..., the requirements of section 12(d) of the National Technology Transfer and Advancement Act of 1995 (15...

Gathering Requirements for Teacher Tools: Strategies for Empowering Teachers through Co-Design

ERIC Educational Resources Information Center

Matuk, Camillia; Gerard, Libby; Lim-Breitbart, Jonathan; Linn, Marcia

2016-01-01

Technology can enhance teachers' practice in multiple ways. It can help them better understand patterns in their students' thinking, manage class progress at individual and group levels, and obtain evidence to inform modifications to curriculum and instruction. Such technology is most effective when it is aligned with teachers' goals and…

The Promise of Technology. Proceedings of the Annual Conference on Rehabilitation Engineering (6th, San Diego, California, June 12-16, 1983). Volume 3.

ERIC Educational Resources Information Center

Bowman, Bruce R., Ed.

These proceedings contain abstracts of 164 papers in the area of interdisciplinary rehabilitation research, focusing on the theme of "The Promise of Technology." The abstracts are organized into the following sections: "Home and Worksite Modification,""Computers and Microprocessor Systems,""Neuromuscular…

76 FR 31425 - HIPAA Privacy Rule Accounting of Disclosures Under the Health Information Technology for Economic...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-31

... 164 HIPAA Privacy Rule Accounting of Disclosures Under the Health Information Technology for Economic... accounting of disclosures of protected health information. The purpose of these modifications is, in part, to...) provides that an accounting must include all disclosures of protected health information, except for...

Consumer-Directed Goal Planning in the Delivery of Assistive Technology Services for People Who Are Ageing with Intellectual Disabilities

ERIC Educational Resources Information Center

Mirza, Mansha; Hammel, Joy

2009-01-01

Background: A consumer-directed service-delivery approach to assistive technology and environmental modification intervention was examined with people who were ageing with intellectual disabilities. Material and Methods: The intervention was based on a collaborative approach involving consumers, their social supports and service deliverers. Thirty…

Effects of Assistive Technology on Functional Decline in People Aging with a Disability

ERIC Educational Resources Information Center

Wilson, Dorothy J.; Mitchell, Judith M.; Kemp, Bryan J.; Adkins, Rodney H.; Mann, William

2009-01-01

This study used a randomized control group design to investigate the impact of an assistive technology and home modification intervention on function for individuals who are aging with a disability. There were 91 participants with polio, rheumatoid arthritis, cerebral palsy, spinal cord injury, stroke, and other impairments. Outcome data were…

Using of material-technological modelling for designing production of closed die forgings

NASA Astrophysics Data System (ADS)

Ibrahim, K.; Vorel, I.; Jeníček, Š.; Káňa, J.; Aišman, D.; Kotěšovec, V.

2017-02-01

Production of forgings is a complex and demanding process which consists of a number of forging operations and, in many cases, includes post-forge heat treatment. An optimized manufacturing line is a prerequisite for obtaining prime-quality products which in turn are essential to profitable operation of a forging company. Problems may, however, arise from modifications to the manufacturing route due to changing customer needs. As a result, the production may have to be suspended temporarily to enable changeover and optimization. Using material-technological modelling, the required modifications can be tested and optimized under laboratory conditions outside the plant without disrupting the production. Thanks to material-technological modelling, the process parameters can be varied rapidly in response to changes in market requirements. Outcomes of the modelling runs include optimum parameters for the forging part’s manufacturing route, values of mechanical properties, and results of microstructure analysis. This article describes the use of material-technological modelling for exploring the impact of the amount of deformation and the rate of cooling of a particular forged part from the finish-forging temperature on its microstructure and related mechanical properties.

Genome scale engineering techniques for metabolic engineering.

PubMed

Liu, Rongming; Bassalo, Marcelo C; Zeitoun, Ramsey I; Gill, Ryan T

2015-11-01

Metabolic engineering has expanded from a focus on designs requiring a small number of genetic modifications to increasingly complex designs driven by advances in genome-scale engineering technologies. Metabolic engineering has been generally defined by the use of iterative cycles of rational genome modifications, strain analysis and characterization, and a synthesis step that fuels additional hypothesis generation. This cycle mirrors the Design-Build-Test-Learn cycle followed throughout various engineering fields that has recently become a defining aspect of synthetic biology. This review will attempt to summarize recent genome-scale design, build, test, and learn technologies and relate their use to a range of metabolic engineering applications. Copyright © 2015 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

Research trends in biomimetic medical materials for tissue engineering: 3D bioprinting, surface modification, nano/micro-technology and clinical aspects in tissue engineering of cartilage and bone.

PubMed

Chen, Cen; Bang, Sumi; Cho, Younghak; Lee, Sahnghoon; Lee, Inseop; Zhang, ShengMin; Noh, Insup

2016-01-01

This review discusses about biomimetic medical materials for tissue engineering of bone and cartilage, after previous scientific commentary of the invitation-based, Korea-China joint symposium on biomimetic medical materials, which was held in Seoul, Korea, from October 22 to 26, 2015. The contents of this review were evolved from the presentations of that symposium. Four topics of biomimetic medical materials were discussed from different research groups here: 1) 3D bioprinting medical materials, 2) nano/micro-technology, 3) surface modification of biomaterials for their interactions with cells and 4) clinical aspects of biomaterials for cartilage focusing on cells, scaffolds and cytokines.

Enabling technologies and green processes in cyclodextrin chemistry.

PubMed

Cravotto, Giancarlo; Caporaso, Marina; Jicsinszky, Laszlo; Martina, Katia

2016-01-01

The design of efficient synthetic green strategies for the selective modification of cyclodextrins (CDs) is still a challenging task. Outstanding results have been achieved in recent years by means of so-called enabling technologies, such as microwaves, ultrasound and ball mills, that have become irreplaceable tools in the synthesis of CD derivatives. Several examples of sonochemical selective modification of native α-, β- and γ-CDs have been reported including heterogeneous phase Pd- and Cu-catalysed hydrogenations and couplings. Microwave irradiation has emerged as the technique of choice for the production of highly substituted CD derivatives, CD grafted materials and polymers. Mechanochemical methods have successfully furnished greener, solvent-free syntheses and efficient complexation, while flow microreactors may well improve the repeatability and optimization of critical synthetic protocols.

An airborne remote sensing platform of the Helsinki University of Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nikulainen, M.; Hallikainen, M.; Kemppinen, M.

1996-10-01

In 1994 Helsinki University of Technology acquired a Short SC7 Skyvan turboprop aircraft to be modified to carry remote sensing instruments. As the aircraft is originally designed to carry heavy and space consuming cargo, a modification program was implemented to make the aircraft feasible for remote sensing operations. The twelve-month long modification program had three design objectives: flexibility, accessibility and cost efficiency. The aircraft interior and electrical system were modified. Furthermore, the aircraft is equipped with DGPS-navigation system, multi-channel radiometer system and side looking airborne radar. Future projects include installation of local area network, attitude GPS system, imaging spectrometer andmore » 1.4 GHz radiometer. 6 refs., 5 figs., 1 tab.« less

Air Quality Side Event Proposal November 2016 GEO XIII ...

EPA Pesticide Factsheets

The Group on Earth Observations (GEO), which EPA has participated in since 2003, has put out a call for Side Events for its thirteenth annual international Plenary Meeting which is in St. Petersburg, Russia this year during November, 2016. EPA has put on Side Events on Air Quality and Health observational systems at eight of the previous Plenaries. This document is a Side Event proposal regarding air quality, health and next generation monitoring and observations techniques. It is submitted to the GEO Secretariat for consideration. If accepted, there will likely be presentations by EPA and NASA, other GEO Member Countries and UNEP and other GEO Participating Organizations at the Side Event. It is an opportunity to share scientific and technological advances in this area and build partnerships and collaboration. The Group on Earth Observations (GEO), which EPA has participated in since 2003, has put out a call for Side Events for its thirteenth annual international Plenary Meeting which is in St. Petersburg, Russia this year during November, 2016. EPA has put on Side Events on Air Quality and Health observational systems at eight of the previous Plenaries. This document is a Side Event proposal regarding air quality, health and next generation monitoring and observations techniques.  It is submitted to the GEO Secretariat for consideration. If accepted, there will likely be presentations by EPA and NASA, other GEO Member Countries and UNEP and other GEO P

Heat insulation performance, mechanics and hydrophobic modification of cellulose-SiO2 composite aerogels.

PubMed

Shi, Jianjun; Lu, Lingbin; Guo, Wantao; Zhang, Jingying; Cao, Yang

2013-10-15

Cellulose-SiO2 composite hydrogel was prepared by combining the NaOH/thiourea/H2O solvent system and the immersion method with controlling the hydrolysis-fasculation rate of tetraethyl orthosilicate (TEOS). The hydrophobic composite aerogels were obtained through the freeze-drying technology and the cold plasma modification technology. Composite SiO2 could obviously reduce the thermal conductivity of cellulose aerogel. The thermal conductivity could be as low as 0.026 W/(mK). The thermal insulation mechanism of the aerogel material was discussed. Composite SiO2 reduced hydrophilicity of cellulose aerogel, but environmental humidity had a significant influence on heat insulation performance. After hydrophobic modification using CCl4 as plasma was conducted, the surface of composite aerogel was changed from hydrophilic to hydrophobic and water contact angle was as high as 132°. The modified composite aerogel still kept good heat insulation performance. This work provided a foundation for the possibility of applying cellulose-SiO2 composite aerogel in the insulating material field. Copyright © 2013 Elsevier Ltd. All rights reserved.

Modifications to the HIPAA Privacy, Security, Enforcement, and Breach Notification rules under the Health Information Technology for Economic and Clinical Health Act and the Genetic Information Nondiscrimination Act; other modifications to the HIPAA rules.

PubMed

2013-01-25

The Department of Health and Human Services (HHS or ``the Department'') is issuing this final rule to: Modify the Health Insurance Portability and Accountability Act (HIPAA) Privacy, Security, and Enforcement Rules to implement statutory amendments under the Health Information Technology for Economic and Clinical Health Act (``the HITECH Act'' or ``the Act'') to strengthen the privacy and security protection for individuals' health information; modify the rule for Breach Notification for Unsecured Protected Health Information (Breach Notification Rule) under the HITECH Act to address public comment received on the interim final rule; modify the HIPAA Privacy Rule to strengthen the privacy protections for genetic information by implementing section 105 of Title I of the Genetic Information Nondiscrimination Act of 2008 (GINA); and make certain other modifications to the HIPAA Privacy, Security, Breach Notification, and Enforcement Rules (the HIPAA Rules) to improve their workability and effectiveness and to increase flexibility for and decrease burden on the regulated entities.

Analysis of pre-service physics teacher skills designing simple physics experiments based technology

NASA Astrophysics Data System (ADS)

Susilawati; Huda, C.; Kurniawan, W.; Masturi; Khoiri, N.

2018-03-01

Pre-service physics teacher skill in designing simple experiment set is very important in adding understanding of student concept and practicing scientific skill in laboratory. This study describes the skills of physics students in designing simple experiments based technologicall. The experimental design stages include simple tool design and sensor modification. The research method used is descriptive method with the number of research samples 25 students and 5 variations of simple physics experimental design. Based on the results of interviews and observations obtained the results of pre-service physics teacher skill analysis in designing simple experimental physics charged technology is good. Based on observation result, pre-service physics teacher skill in designing simple experiment is good while modification and sensor application are still not good. This suggests that pre-service physics teacher still need a lot of practice and do experiments in designing physics experiments using sensor modifications. Based on the interview result, it is found that students have high enough motivation to perform laboratory activities actively and students have high curiosity to be skilled at making simple practicum tool for physics experiment.

Congenital Myasthenic Syndrome Type 19 Is Caused by Mutations in COL13A1, Encoding the Atypical Non-fibrillar Collagen Type XIII α1 Chain.

PubMed

Logan, Clare V; Cossins, Judith; Rodríguez Cruz, Pedro M; Parry, David A; Maxwell, Susan; Martínez-Martínez, Pilar; Riepsaame, Joey; Abdelhamed, Zakia A; Lake, Alice V R; Moran, Maria; Robb, Stephanie; Chow, Gabriel; Sewry, Caroline; Hopkins, Philip M; Sheridan, Eamonn; Jayawant, Sandeep; Palace, Jacqueline; Johnson, Colin A; Beeson, David

2015-12-03

The neuromuscular junction (NMJ) consists of a tripartite synapse with a presynaptic nerve terminal, Schwann cells that ensheathe the terminal bouton, and a highly specialized postsynaptic membrane. Synaptic structural integrity is crucial for efficient signal transmission. Congenital myasthenic syndromes (CMSs) are a heterogeneous group of inherited disorders that result from impaired neuromuscular transmission, caused by mutations in genes encoding proteins that are involved in synaptic transmission and in forming and maintaining the structural integrity of NMJs. To identify further causes of CMSs, we performed whole-exome sequencing (WES) in families without an identified mutation in known CMS-associated genes. In two families affected by a previously undefined CMS, we identified homozygous loss-of-function mutations in COL13A1, which encodes the alpha chain of an atypical non-fibrillar collagen with a single transmembrane domain. COL13A1 localized to the human muscle motor endplate. Using CRISPR-Cas9 genome editing, modeling of the COL13A1 c.1171delG (p.Leu392Sfs(∗)71) frameshift mutation in the C2C12 cell line reduced acetylcholine receptor (AChR) clustering during myotube differentiation. This highlights the crucial role of collagen XIII in the formation and maintenance of the NMJ. Our results therefore delineate a myasthenic disorder that is caused by loss-of-function mutations in COL13A1, encoding a protein involved in organization of the NMJ, and emphasize the importance of appropriate symptomatic treatment for these individuals. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Clotting of mammalian fibrinogens by papain: a re-examination.

PubMed

Doolittle, Russell F

2014-10-28

Papain has long been known to cause the gelation of mammalian fibrinogens. It has also been reported that papain-fibrin is insoluble in dispersing solvents like strong urea or sodium bromide solutions, similar to what is observed with thrombin-generated clots in the presence of factor XIIIa and calcium. In those old studies, both the gelation and subsequent clot stabilization were attributed to papain, although the possibility that the second step might be due to contaminating factor XIII in fibrinogen preparations was considered. I have revisited this problem in light of knowledge acquired over the past half-century about thiol proteases like papain, which mostly cleave peptide bonds, and transglutaminases like factor XIIIa that catalyze the formation of ε-lysyl-γ-glutamyl cross-links. Recombinant fibrinogen, inherently free of factor XIII and other plasma proteins, formed a stable gel when treated with papain alone. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed that the intermolecular cross-linking in papain-fibrin leads to γ-chain dimers, trimers, and tetramers, just as is the case with thrombin-factor XIIIa-stabilized fibrin. Mass spectrometry of bands excised from gels showed that the cross-linked material is quite different from what occurs with factor XIIIa, however. With papain, the cross-linking occurs between γ chains in neighboring protofibrils becoming covalently linked in a "head-to-tail" fashion by a transpeptidation reaction involving the α-amino group of γ-Tyr1 and a papain cleavage site at γ-Gly403 near the carboxy terminus, rather than by the (reciprocal) "tail-to-tail" manner that occurs with factor XIIIa and that depends on cross-links between γ-Lys406 and γ-Gln398.

The in vivo effect of fibrinogen and factor XIII on clot formation and fibrinolysis in Glanzmann's thrombasthenia.

PubMed

Shenkman, Boris; Livnat, Tami; Misgav, Mudi; Budnik, Ivan; Einav, Yulia; Martinowitz, Uriel

2012-01-01

Glanzmann's thrombasthenia (GT) is characterized by increased bleeding risk. The treatment options in GT are limited. The aim of this study was to test the effect of GT blood supplementation with fibrinogen and factor XIII on thrombin generation, blood clotting, and fibrinolysis. Whole blood samples of GT patients and normal donors treated with eptifibatide (GT model) were subjected to clotting by CaCl(2) and tissue factor. Thrombin generation was measured in platelet-rich plasma. Clot formation and tPA-induced fibrinolysis were evaluated in whole blood by rotation thromboelastometry (ROTEM). Blood was supplemented with fibrinogen (3 g/L) and/or FXIII (2 IU/mL). Thrombin generation analysis of blood derived from GT model and GT patients revealed decreased endogenous thrombin potential and peak height and extended lag time compared to control. However, this method was not sensitive to blood spiking with fibrinogen and FXIII. ROTEM revealed lower maximum clot firmness (MCF) and area under curve (AUC) in the blood of GT model and GT patients. In the absence of exogenous tPA, blood spiking with fibrinogen markedly enhanced clot quality while FXIII had no effect. Combination of fibrinogen and FXIII did not add to the effect of fibrinogen. In contrast, by the addition of tPA, both fibrinogen and FXIII separately and, to more extent, in combination enhanced clot quality as well as resistance against tPA-induced fibrinolysis (increasing MCF, AUC, and lysis onset time). In conclusion, fibrinogen and FXIII exerted stimulation of blood clotting and inhibition of fibrinolysis. Treating normal blood with eptifibatide mimics the changes of coagulopathy in GT blood.

Evaluation of Factor V G1691A, prothrombin G20210A, Factor XIII V34L, MTHFR A1298C, MTHFR C677T and PAI-1 4G/5G genotype frequencies of patients subjected to cardiovascular disease (CVD) panel in south-east region of Turkey.

PubMed

Oztuzcu, Serdar; Ergun, Sercan; Ulaşlı, Mustafa; Nacarkahya, Gülper; Iğci, Yusuf Ziya; Iğci, Mehri; Bayraktar, Recep; Tamer, Ali; Çakmak, Ecir Ali; Arslan, Ahmet

2014-06-01

Cardiovascular disease (CVD) risk factors, such as arterial hypertension, obesity, dyslipidemia or diabetes mellitus, as well as CVDs, including myocardial infarction, coronary artery disease or stroke, are the most prevalent diseases and account for the major causes of death worldwide. In the present study, 4,709 unrelated patients subjected to CVD panel in south-east part of Turkey between the years 2010 and 2013 were enrolled and DNA was isolated from the blood samples of these patients. Mutation analyses were conducted using the real-time polymerase chain reaction method to screen six common mutations (Factor V G1691A, PT G20210A, Factor XIII V34L, MTHFR A1298C and C677T and PAI-1 -675 4G/5G) found in CVD panel. The prevalence of these mutations were 0.57, 0.25, 2.61, 13.78, 9.34 and 24.27 % in homozygous form, respectively. Similarly, the mutation percent of them in heterozygous form were 7.43, 3.44, 24.91, 44.94, 41.09 and 45.66%, respectively. No mutation was detected in 92 (1.95%) patients in total. Because of the fact that this is the first study to screen six common mutations in CVD panel in south-east region of Turkey, it has a considerable value on the diagnosis and treatment of these diseases. Upon the results of the present and previous studied a careful examination for these genetic variants should be carried out in thrombophilia screening programs, particularly in Turkish population.

ORANGE: a Monte Carlo dose engine for radiotherapy.

PubMed

van der Zee, W; Hogenbirk, A; van der Marck, S C

2005-02-21

This study presents data for the verification of ORANGE, a fast MCNP-based dose engine for radiotherapy treatment planning. In order to verify the new algorithm, it has been benchmarked against DOSXYZ and against measurements. For the benchmarking, first calculations have been done using the ICCR-XIII benchmark. Next, calculations have been done with DOSXYZ and ORANGE in five different phantoms (one homogeneous, two with bone equivalent inserts and two with lung equivalent inserts). The calculations have been done with two mono-energetic photon beams (2 MeV and 6 MeV) and two mono-energetic electron beams (10 MeV and 20 MeV). Comparison of the calculated data (from DOSXYZ and ORANGE) against measurements was possible for a realistic 10 MV photon beam and a realistic 15 MeV electron beam in a homogeneous phantom only. For the comparison of the calculated dose distributions and dose distributions against measurements, the concept of the confidence limit (CL) has been used. This concept reduces the difference between two data sets to a single number, which gives the deviation for 90% of the dose distributions. Using this concept, it was found that ORANGE was always within the statistical bandwidth with DOSXYZ and the measurements. The ICCR-XIII benchmark showed that ORANGE is seven times faster than DOSXYZ, a result comparable with other accelerated Monte Carlo dose systems when no variance reduction is used. As shown for XVMC, using variance reduction techniques has the potential for further acceleration. Using modern computer hardware, this brings the total calculation time for a dose distribution with 1.5% (statistical) accuracy within the clinical range (less then 10 min). This means that ORANGE can be a candidate for a dose engine in radiotherapy treatment planning.

77 FR 29564 - Revisions to the Export Administration Regulations: Auxiliary and Miscellaneous Items That No...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

...The Bureau of Industry and Security (BIS) publishes this action to propose how auxiliary and miscellaneous military equipment and related articles the President determines no longer warrant control under Category XIII (Auxiliary Military Equipment) of the United States Munitions List (USML) would be controlled under the Commerce Control List (CCL) in new Export Control Classification Numbers (ECCNs) 0A617, 0B617, 0C617, 0D617, and 0E617 as part of the proposed new ``600 series'' of ECCNs. This rule proposes also to integrate into those five new ECCNs items within the scope of Wassenaar Arrangement Munitions List (WAML) Category 17 that would be removed from the USML, or that are not specifically identified on the USML or CCL but that are currently subject to USML jurisdiction. Finally, this rule proposes to control some items now classified under ECCNs 0A018, 0A918 and 0E018 under new ECCNs 0A617 and 0E617. This action would consolidate the above- mentioned auxiliary and miscellaneous military equipment and related articles on the CCL in the proposed new ``600 series.'' This rule is one of a planned series proposing how various types of articles that the President determines, as part of the Administration's Export Control Reform Initiative, no longer warrant control on the USML under the International Traffic in Arms Regulations (ITAR), would be controlled on the CCL in accordance with the requirements of the Export Administration Regulations (EAR). This proposed rule is being published in conjunction with a proposed rule from the Department of State, Directorate of Defense Trade Controls, which would amend the list of articles controlled by USML Category XIII.

Establishment of a prenatal diagnosis schedule as part of a prophylaxis program of factor XIII deficiency in the southeast of Iran.

PubMed

Naderi, Majid; Reykande, Samira Esmaeili; Dorgalaleh, Akbar; Alizadeh, Shaban; Tabibian, Shadi; Einollahi, Nahid; Moghaddam, Ebrahim Miri

2016-01-01

Factor XIII deficiency (FXIIID) is an extremely rare bleeding disorder with a prevalence of 1 in 3 million in the general population. Compared to its global incidence, it has the greatest prevalence in Sistan and Baluchistan Province in the southeast of Iran. The high incidence of FXIIID in this region causes a high rate of morbidity and mortality among the affected individuals because of life-threatening episodes such as central nervous system (CNS) bleeding, umbilical cord bleeding, as well as miscarriage. CNS bleeding leads to a considerable number of neurological and behavioral complications. Therefore, we have designed an established prenatal diagnosis (PND) program to prevent the increasing incidence of life-threatening bleeding episodes and related complications among neonates with congenital FXIIID. This study was conducted from September 2013 to August 2014. A consent form was signed by the parents. Fetal sampling was done via abdominal chorionic villus sampling passage under local anesthesia and ultrasonic guidance within the first trimester of pregnancy. Fetal DNA was extracted, and PCR-restriction fragment length polymorphism was performed for the only reported mutation of FXIII (Trp187Arg) in the southeast of Iran. During the period of study, PND was performed on eight fetuses. Six fetuses were offspring of parental consanguineous marriages, and all of them had a positive family history of FXIIID. Seven out of the eight fetuses had a family member with CNS bleeding due to FXIIID. Four fetuses had a FXIIID-related death. One of the fetuses bore homozygous Trp187Arg mutation, whereas six were heterozygous, and one of the mothers gave birth to an unaffected fetus. To the best of our knowledge, PND is a possible solution to control high incidence of life-threatening episodes of FXIIID in southeast Iran.

Advances in the surface modification techniques of bone-related implants for last 10 years

PubMed Central

Qiu, Zhi-Ye; Chen, Cen; Wang, Xiu-Mei; Lee, In-Seop

2014-01-01

At the time of implanting bone-related implants into human body, a variety of biological responses to the material surface occur with respect to surface chemistry and physical state. The commonly used biomaterials (e.g. titanium and its alloy, Co–Cr alloy, stainless steel, polyetheretherketone, ultra-high molecular weight polyethylene and various calcium phosphates) have many drawbacks such as lack of biocompatibility and improper mechanical properties. As surface modification is very promising technology to overcome such problems, a variety of surface modification techniques have been being investigated. This review paper covers recent advances in surface modification techniques of bone-related materials including physicochemical coating, radiation grafting, plasma surface engineering, ion beam processing and surface patterning techniques. The contents are organized with different types of techniques to applicable materials, and typical examples are also described. PMID:26816626

Heritability of targeted gene modifications induced by plant-optimized CRISPR systems.

PubMed

Mao, Yanfei; Botella, Jose Ramon; Zhu, Jian-Kang

2017-03-01

The Streptococcus-derived CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas9 (CRISPR-associated protein 9) system has emerged as a very powerful tool for targeted gene modifications in many living organisms including plants. Since the first application of this system for plant gene modification in 2013, this RNA-guided DNA endonuclease system has been extensively engineered to meet the requirements of functional genomics and crop trait improvement in a number of plant species. Given its short history, the emphasis of many studies has been the optimization of the technology to improve its reliability and efficiency to generate heritable gene modifications in plants. Here we review and analyze the features of customized CRISPR/Cas9 systems developed for plant genetic studies and crop breeding. We focus on two essential aspects: the heritability of gene modifications induced by CRISPR/Cas9 and the factors affecting its efficiency, and we provide strategies for future design of systems with improved activity and heritability in plants.

Utilizing Technology to Examine the Impacts of Academic Program Plans on Faculty Staffing Levels. AIR 1984 Annual Forum Paper.

ERIC Educational Resources Information Center

Spiro, Louis M.; Campbell, Jill F.

The development and use of a campus-based computerized faculty staffing model is described. In addition to considering market demands for current and proposed programs, decisionmakers need to consider how program development, modification, and elimination affect the total college faculty resource base. The application of computer technology,…

IMPACTT5A model : enhancements and modifications since December 1994 with special reference to the effect of tripled-fuel-economy vehicles on fuel-cycle energy and emissions

DOT National Transportation Integrated Search

1998-09-01

Version 5A of the Integrated Market Penetration and Anticipated Cost of Transportation Technologies (IMPACIT5A) model is a spreadsheet-based set of algorithms that calculates the effects of advanced-technology vehicles on baseline fuel use and emi...

Environmental Law Deskbook

DTIC Science & Technology

1991-10-01

Agency FFA Federal Facilities Agreement FFCA Federal Facilities Compliance Agreement FGD Flue Gas Desulfurization FIFRA Federal Insecticide, Fungicide...carrying out response. If none, state why. EXAMPLE: Gas barriers used to control and contain vapor emissions. Runoff contained by excavating ditch...NPDES PERMITS 20-2 2006 WATER QUALITY STANDARDS 20-2 2007 POLLUTION CONTROL TECHNOLOGY 20-3 2008 TECHNOLOGY VARIANCE AND MODIFICATIONS 20-4 2009

Field Operations and Enforcement Manual for Air Pollution Control. Volume II: Control Technology and General Source Inspection.

ERIC Educational Resources Information Center

Weisburd, Melvin I.

The Field Operations and Enforcement Manual for Air Pollution Control, Volume II, explains in detail the following: technology of source control, modification of operations, particulate control equipment, sulfur dioxide removal systems for power plants, and control equipment for gases and vapors; inspection procedures for general sources, fuel…

Oak Seedlings: Quality Improved Available Now Genetically Improved Available Soon

Treesearch

S.E. Schlarbaum; Paul P. Kormanik; T. Tibbs; L.R. Barber

1997-01-01

Technology for obtaining natural oak regeneration on low quality upland sites, e.g. site indices of 60-65 or less, was developed in the Central Statesregion and has been successfully applied throughout the eastern United States (Sanderand Graney 1993, Clark 1993, Sander 1972). Modification of this technology for use on high quality mesic sites, productive coves and...

Nanoparticles for Site Specific Genome Editing

NASA Astrophysics Data System (ADS)

McNeer, Nicole Ali

Triplex-forming peptide nucleic acids (PNAs) can be used to coordinate the recombination of short 50-60 by "donor DNA" fragments into genomic DNA, resulting in site-specific correction of genetic mutations or the introduction of advantageous genetic modifications. Site-specific gene editing in hematopoietic stem and progenitor cells (HSPCs) could result in treatment or cure of inherited disorders of the blood such as beta-thalassemia. Gene editing in HSPCs and differentiated T cells could help combat HIV/AIDs by modifying receptors, such as CCR5, necessary for R5-tropic HIV entry. However, translation of genome modification technologies to clinical practice is limited by challenges in intracellular delivery, especially in difficult-to-transfect hematolymphoid cells. In vivo gene editing could also provide novel treatment for systemic monogenic disorders such as cystic fibrosis, an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor. Here, we have engineered biodegradable nanoparticles to deliver oligonucleotides for site-specific genome editing of disease-relevant genes in human cells, with high efficiency, low toxicity, and editing of clinically relevant cell types. We designed nanoparticles to edit the human beta-globin and CCR5 genes in hematopoietic cells. We show that poly(lactic-co-glycolic acid) (PLGA) nanoparticles can delivery PNA and donor DNA for site-specific gene modification in human hematopoietic cells in vitro and in vivo in NOD-scid IL2rgammanull mice. Nanoparticles delivered by tail vein localized to hematopoietic compartments in the spleen and bone marrow of humanized mice, resulting in modification of the beta-globin and CCR5 genes. Modification frequencies ranged from 0.005 to 20% of cells depending on the organ and cell type, without detectable toxicity. This project developed highly versatile methods for delivery of therapeutics to hematolymphoid cells and hematopoietic stem cells, and will help to translate gene therapies for diseases of the blood and immune system to clinical practice. In addition, we have expanded the use of this technology to an additional nonhematopoietic model system: correction of the human cystic fibrosis transmembrane receptor gene in human bronchial epithelial cells. The work presented here represents (1) the first use of biodegradable nanoparticles for PNA delivery, (2) the first direct in vivo site-specific genome modification in human cells, and (3) the first use of triplex-PNA technology for site-specific genome editing in cystic fibrosis.

Orbital Atherectomy in the Renal Artery: A New Frontier for an Emerging Technology?

PubMed

Valle, Javier A; Armstrong, Ehrin J; Waldo, Stephen W

2017-01-01

Orbital atherectomy has been developed as a method to modify calcified plaque in the peripheral vasculature, with extensive experience and data supporting its use in infrainguinal peripheral arterial disease. However, calcific atherosclerotic disease occurs in other vascular beds and may benefit from the application of this technology. In this case report, we describe the first reported use of orbital atherectomy in a renal artery. A 55-year-old male with severe drug-refractory hypertension was found to have renal artery stenosis, with severe calcification of the right renal artery. Orbital atherectomy was utilized for initial plaque modification, and he underwent stenting of the renal artery lesion with an excellent angiographic and clinical result at follow-up. In conclusion, orbital atherectomy is a safe and effective means of plaque modification for severely calcified lesions. The safe and effective use of orbital atherectomy in the renal vasculature suggests an opportunity for ongoing evaluation into expanded roles for this technology beyond the coronary and lower-extremity arterial beds.

Induced mutation and epigenetics modification in plants for crop improvement by targeting CRISPR/Cas9 technology.

PubMed

Khan, Muhammad Hafeez Ullah; Khan, Shahid U; Muhammad, Ali; Hu, Limin; Yang, Yang; Fan, Chuchuan

2018-06-01

Clustered regularly interspaced palindromic repeats associated protein Cas9 (CRISPR-Cas9), originally an adaptive immunity system of prokaryotes, is revolutionizing genome editing technologies with minimal off-targets in the present era. The CRISPR/Cas9 is now highly emergent, advanced, and highly specific tool for genome engineering. The technology is widely used to animal and plant genomes to achieve desirable results. The present review will encompass how CRISPR-Cas9 is revealing its beneficial role in characterizing plant genetic functions, genomic rearrangement, how it advances the site-specific mutagenesis, and epigenetics modification in plants to improve the yield of field crops with minimal side-effects. The possible pitfalls of using and designing CRISPR-Cas9 for plant genome editing are also discussed for its more appropriate applications in plant biology. Therefore, CRISPR/Cas9 system has multiple benefits that mostly scientists select for genome editing in several biological systems. © 2017 Wiley Periodicals, Inc.

Status of Technological Advancements for Reducing Aircraft Gas Turbine Engine Pollutant Emissions

NASA Technical Reports Server (NTRS)

Rudey, R. A.

1975-01-01

Combustor test rig results indicate that substantial reductions from current emission levels of carbon monoxide (CO), total unburned hydrocarbons (THC), oxides of nitrogen (NOx), and smoke are achievable by employing varying degrees of technological advancements in combustion systems. Minor to moderate modifications to existing conventional combustors produced significant reductions in CO and THC emissions at engine low power (idle/taxi) operating conditions but did not effectively reduce NOx at engine full power (takeoff) operating conditions. Staged combusiton techniques were needed to simultaneously reduce the levels of all the emissions over the entire engine operating range (from idle to takeoff). Emission levels that approached or were below the requirements of the 1979 EPA standards were achieved with the staged combustion systems and in some cases with the minor to moderate modifications to existing conventional combustion systems. Results from research programs indicate that an entire new generation of combustor technology with extremely low emission levels may be possible in the future.

Virus-Derived Gene Expression and RNA Interference Vector for Grapevine

PubMed Central

Kurth, Elizabeth G.; Peremyslov, Valera V.; Prokhnevsky, Alexey I.; Kasschau, Kristin D.; Miller, Marilyn; Carrington, James C.

2012-01-01

The improvement of the agricultural and wine-making qualities of the grapevine (Vitis vinifera) is hampered by adherence to traditional varieties, the recalcitrance of this plant to genetic modifications, and public resistance to genetically modified organism (GMO) technologies. To address these challenges, we developed an RNA virus-based vector for the introduction of desired traits into grapevine without heritable modifications to the genome. This vector expresses recombinant proteins in the phloem tissue that is involved in sugar transport throughout the plant, from leaves to roots to berries. Furthermore, the vector provides a powerful RNA interference (RNAi) capability of regulating the expression of endogenous genes via virus-induced gene-silencing (VIGS) technology. Additional advantages of this vector include superb genetic capacity and stability, as well as the swiftness of technology implementation. The most significant applications of the viral vector include functional genomics of the grapevine and disease control via RNAi-enabled vaccination against pathogens or invertebrate pests. PMID:22438553