Multiplexed fluorescence detector system for capillary electrophoresis

DOEpatents

Yeung, Edward S.; Taylor, John A.

1994-06-28

A fluorescence detection system for capillary electrophoresis is provided wherein the detection system can simultaneously excite fluorescence and substantially simultaneously monitor separations in multiple capillaries. This multiplexing approach involves laser irradiation of a sample in a plurality of capillaries through optical fibers that are coupled individually with the capillaries. The array is imaged orthogonally through a microscope onto a charge-coupled device camera for signal analysis.

Unobtrusive measurement of indoor energy expenditure using an infrared sensor-based activity monitoring system.

PubMed

Hwang, Bosun; Han, Jonghee; Choi, Jong Min; Park, Kwang Suk

2008-11-01

The purpose of this study was to develop an unobtrusive energy expenditure (EE) measurement system using an infrared (IR) sensor-based activity monitoring system to measure indoor activities and to estimate individual quantitative EE. IR-sensor activation counts were measured with a Bluetooth-based monitoring system and the standard EE was calculated using an established regression equation. Ten male subjects participated in the experiment and three different EE measurement systems (gas analyzer, accelerometer, IR sensor) were used simultaneously in order to determine the regression equation and evaluate the performance. As a standard measurement, oxygen consumption was simultaneously measured by a portable metabolic system (Metamax 3X, Cortex, Germany). A single room experiment was performed to develop a regression model of the standard EE measurement from the proposed IR sensor-based measurement system. In addition, correlation and regression analyses were done to compare the performance of the IR system with that of the Actigraph system. We determined that our proposed IR-based EE measurement system shows a similar correlation to the Actigraph system with the standard measurement system.

Display/control requirements for automated VTOL aircraft

NASA Technical Reports Server (NTRS)

Hoffman, W. C.; Kleinman, D. L.; Young, L. R.

1976-01-01

A systematic design methodology for pilot displays in advanced commercial VTOL aircraft was developed and refined. The analyst is provided with a step-by-step procedure for conducting conceptual display/control configurations evaluations for simultaneous monitoring and control pilot tasks. The approach consists of three phases: formulation of information requirements, configuration evaluation, and system selection. Both the monitoring and control performance models are based upon the optimal control model of the human operator. Extensions to the conventional optimal control model required in the display design methodology include explicit optimization of control/monitoring attention; simultaneous monitoring and control performance predictions; and indifference threshold effects. The methodology was applied to NASA's experimental CH-47 helicopter in support of the VALT program. The CH-47 application examined the system performance of six flight conditions. Four candidate configurations are suggested for evaluation in pilot-in-the-loop simulations and eventual flight tests.

End-Use Load and Conservation Assessment Program : Co-Instrumentation Test of Two Microcomputer-Based Energy Monitoring Systems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fishbaugher, M. J.

1985-05-01

The decreasing cost of microcomputers along with improvements in power metering circuitry have changed the way in which electrical energy use is monitored. Although utilities still rely on kilowatt-hour (kWh) meters for billing purposes, a microcomputer-based monitoring system is used when greater temporal and end-use resolution is desired. Because these types of monitoring systems will be used increasingly in large-scale conservation and end-use studies, it is important that their performance be analyzed to determine their accuracy. A co-instrumentation test was devised in which two such microcomputer-based monitoring systems made simultaneous measurements of electrical end-uses in two commercial buildings. The analysismore » of the co-instrumentation data aids in the evaluation of microcomputer-based monitoring systems used for end-use measurements. Separate and independent data loggers were used to measure the same loads simultaneously. In addition to these two systems, a utility billing meter measured the total energy use in each building during the co-instrumentation test. The utility's meters provided a relatively accurate standard by which the performance of both loggers could be judged. The comparison between the SCL and PNL microcomputer-based loggers has shown that power measurement techniques directly affect system performance. The co-instrumentation test has shown that there are certain standards that a monitoring system must meet if it is to perform well. First, it is essential to calibrate a microcomputer-based logger against a known standard load before the system is installed. Second, a microcomputer-based system must have some way of accounting for power factors. Recent advances in power metering circuitry have made it relatively easy to apply these power factors automatically in real time.« less

Prototype development of an electrical impedance based simultaneous respiratory and cardiac monitoring system for gated radiotherapy.

PubMed

Kohli, Kirpal; Liu, Jeff; Schellenberg, Devin; Karvat, Anand; Parameswaran, Ash; Grewal, Parvind; Thomas, Steven

2014-10-14

In radiotherapy, temporary translocations of the internal organs and tumor induced by respiratory and cardiac activities can undesirably lead to significantly lower radiation dose on the targeted tumor but more harmful radiation on surrounding healthy tissues. Respiratory and cardiac gated radiotherapy offers a potential solution for the treatment of tumors located in the upper thorax. The present study focuses on the design and development of simultaneous acquisition of respiratory and cardiac signal using electrical impedance technology for use in dual gated radiotherapy. An electronic circuitry was developed for monitoring the bio-impedance change due to respiratory and cardiac motions and extracting the cardiogenic ECG signal. The system was analyzed in terms of reliability of signal acquisition, time delay, and functionality in a high energy radiation environment. The resulting signal of the system developed was also compared with the output of the commercially available Real-time Position Management™ (RPM) system in both time and frequency domains. The results demonstrate that the bioimpedance-based method can potentially provide reliable tracking of respiratory and cardiac motion in humans, alternative to currently available methods. When compared with the RPM system, the impedance-based system developed in the present study shows similar output pattern but different sensitivities in monitoring different respiratory rates. The tracking of cardiac motion was more susceptible to interference from other sources than respiratory motion but also provided synchronous output compared with the ECG signal extracted. The proposed hardware-based implementation was observed to have a worst-case time delay of approximately 33 ms for respiratory monitoring and 45 ms for cardiac monitoring. No significant effect on the functionality of the system was observed when it was tested in a radiation environment with the electrode lead wires directly exposed to high-energy X-Rays. The developed system capable of rendering quality signals for tracking both respiratory and cardiac motions can potentially provide a solution for simultaneous dual-gated radiotherapy.

A Fully Redundant On-Line Mass Spectrometer System Used to Monitor Cryogenic Fuel Leaks on the Space Shuttle

NASA Technical Reports Server (NTRS)

Griffin, Timothy P.; Naylor, Guy R.; Haskell, William D.; Breznik, Greg S.; Mizell, Carolyn A.; Helms, William R.; Voska, N. (Technical Monitor)

2002-01-01

An on-line gas monitoring system was developed to replace the older systems used to monitor for cryogenic leaks on the Space Shuttles before launch. The system uses a mass spectrometer to monitor multiple locations in the process, which allows the system to monitor all gas constituents of interest in a nearly simultaneous manner. The system is fully redundant and meets all requirements for ground support equipment (GSE). This includes ruggedness to withstand launch on the Mobile Launcher Platform (MLP), ease of operation, and minimal operator intervention. The system can be fully automated so that an operator is notified when an unusual situation or fault is detected. User inputs are through personal computer using mouse and keyboard commands. The graphical user for detecting cryogenic leaks, many other gas constituents could be monitored using the Hazardous Gas Detection System (HGDS) 2000.

Simultaneous monitoring of multiple contrast agents using a hybrid MR-DOT system

NASA Astrophysics Data System (ADS)

Gulsen, Gultekin; Unlu, Mehmet Burcin; Birgul, Ozlem; Nalcioglu, Orhan

2007-02-01

Frequency domain diffuse optical tomography (DOT) is a recently emerging technique that uses arrays of sources and detectors to obtain spatially dependent optical parameters of tissue. Here, we describe the design of a hybrid MR-DOT system for dynamic imaging cancer. The combined system acquires both MR and optical data simultaneously. The performance of the system is tested with phantom and in-vivo studies. Gd-DTPA and ICG was used for this purpose and the enhancement kinetics of both agents are recorded using the hybrid system.

Droplet monitoring probe

NASA Technical Reports Server (NTRS)

Baughman, J. R.; Thys, P. C.

1973-01-01

A droplet monitoring system is disclosed for analysis of mixed-phase fluid flow in development of gas turbines. The system uses a probe comprising two electrical wires spaced a known distance apart and connected at one end to means for establishing a dc potential between the wires. A drop in the fluid stream momentarily contacting both wires simultaneously causes and electrical signal which is amplified, detected and counted.

[Implementation of Oncomelania hupensis monitoring system based on Baidu Map].

PubMed

Zhi-Hua, Chen; Yi-Sheng, Zhu; Zhi-Qiang, Xue; Xue-Bing, Li; Yi-Min, Ding; Li-Jun, Bi; Kai-Min, Gao; You, Zhang

2017-10-25

To construct the Oncomelania hupensis snail monitoring system based on the Baidu Map. The environmental basic information about historical snail environment and existing snail environment, etc. was collected with the monitoring data about different kinds of O. hupensis snails, and then the O. hupensis snail monitoring system was built. Geographic Information System (GIS) and the electronic fence technology and Application Program Interface (API) were applied to set up the electronic fence of the snail surveillance environments, and the electronic fence was connected to the database of the snail surveillance. The O. hupensis snail monitoring system based on the Baidu Map were built up, including three modules of O. hupensis Snail Monitoring Environmental Database, Dynamic Monitoring Platform and Electronic Map. The information about monitoring O. hupensis snails could be obtained through the computer and smartphone simultaneously. The O. hupensis snail monitoring system, which is based on Baidu Map, is a visible platform to follow the process of snailsearching and molluscaciding.

A Wearable EEG-HEG-HRV Multimodal System With Simultaneous Monitoring of tES for Mental Health Management.

PubMed

Ha, Unsoo; Lee, Yongsu; Kim, Hyunki; Roh, Taehwan; Bae, Joonsung; Kim, Changhyeon; Yoo, Hoi-Jun

2015-12-01

A multimodal mental management system in the shape of the wearable headband and earplugs is proposed to monitor electroencephalography (EEG), hemoencephalography (HEG) and heart rate variability (HRV) for accurate mental health monitoring. It enables simultaneous transcranial electrical stimulation (tES) together with real-time monitoring. The total weight of the proposed system is less than 200 g. The multi-loop low-noise amplifier (MLLNA) achieves over 130 dB CMRR for EEG sensing and the capacitive correlated-double sampling transimpedance amplifier (CCTIA) has low-noise characteristics for HEG and HRV sensing. Measured three-physiology domains such as neural, vascular and autonomic domain signals are combined with canonical correlation analysis (CCA) and temporal kernel canonical correlation analysis (tkCCA) algorithm to find the neural-vascular-autonomic coupling. It supports highly accurate classification with the 19% maximum improvement with multimodal monitoring. For the multi-channel stimulation functionality, after-effects maximization monitoring and sympathetic nerve disorder monitoring, the stimulator is designed as reconfigurable. The 3.37 × 2.25 mm(2) chip has 2-channel EEG sensor front-end, 2-channel NIRS sensor front-end, NIRS current driver to drive dual-wavelength VCSEL and 6-b DAC current source for tES mode. It dissipates 24 mW with 2 mA stimulation current and 5 mA NIRS driver current.

Fiber-Optic Based Compact Gas Leak Detection System

NASA Technical Reports Server (NTRS)

deGroot, Wim A.

1995-01-01

A propellant leak detection system based on Raman scattering principles is introduced. The proposed system is flexible and versatile as the result of the use of optical fibers. It is shown that multiple species can be monitored simultaneously. In this paper oxygen, nitrogen, carbon monoxide, and hydrogen are detected and monitored. The current detection sensitivity for both hydrogen and carbon monoxide is 1% partial pressure at ambient conditions. The sensitivity for oxygen and nitrogen is 0.5% partial pressure. The response time to changes in species concentration is three minutes. This system can be used to monitor multiple species at several locations.

Real-time monitoring implementation in a remote-pumped WDM PON

NASA Astrophysics Data System (ADS)

Liaw, S.-K.; Hong, K.-L.; Shei, Y.-S.

2008-08-01

We report on an improved configuration to monitor a passive optical network with high quality in service. This proposed system comprises fiber-Bragg gratings, a 1 × 4 optical switch, and an optical time-domain reflectometry to diagnose the broken point in real time. It could simultaneously detect multioptical network units in a WDM PON. The remote-pump integrated residual pumping reused function is implemented. Broken points in different optical paths can be detected simultaneously even when the distances to the central office are identical. The bit-error rate testing is verified with a small power penalty, making it an ideal solution for the real-time monitoring in a WDM PON.

Mobile patient monitoring based on impedance-loaded SAW-sensors.

PubMed

Karilainen, Anna; Finnberg, Thomas; Uelzen, Thorsten; Dembowski, Klaus; Müller, Jörg

2004-11-01

A remotely requestable, passive, short-range sensor network for measuring small voltages is presented. The sensor system is able to simultaneously monitor six small voltages in millivolt-range, and it can be used for Holter-electrocardiogram (ECG) and other biopotential monitoring, or in industrial applications. The sensors are based on a surface acoustic wave (SAW) delay line with voltage-dependent, impedance loading on a reflector interdigital transducer (IDT). The load circuit impedance is varied by the capacitance of the voltage-controlled varactor. High resolution is achieved by developing a MOS-capacitor with a thin oxide, low flat-band voltage, and zero-voltage capacitance in the space-charge region, as well as a high-Q-microcoil by thick metal electroplating. Simultaneous monitoring of multiple potentials is realized by time-division-multiplexing of different sensor signals.

Software design of a remote real-time ECG monitoring system

NASA Astrophysics Data System (ADS)

Yu, Chengbo; Tao, Hongyan

2005-12-01

Heart disease is one of the main diseases that threaten the health and lives of human beings. At present, the normal remote ECG monitoring system has the disadvantages of a short testing distance and limitation of monitoring lines. Because of accident and paroxysmal disease, ECG monitoring has extended from the hospital to the family. Therefore, remote ECG monitoring through the Internet has the actual value and significance. The principle and design method of software of the remote dynamic ECG monitor was presented and discussed. The monitoring software is programmed with Delphi software based on client-sever interactive mode. The application program of the system, which makes use of multithreading technology, is shown to perform in an excellent manner. The program includes remote link users and ECG processing, i.e. ECG data's receiving, real-time displaying, recording and replaying. The system can connect many clients simultaneously and perform real-time monitoring to patients.

Simultaneous probing of bulk liquid phase and catalytic gas-liquid-solid interface under working conditions using attenuated total reflection infrared spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meemken, Fabian; Müller, Philipp; Hungerbühler, Konrad

Design and performance of a reactor set-up for attenuated total reflection infrared (ATR-IR) spectroscopy suitable for simultaneous reaction monitoring of bulk liquid and catalytic solid-liquid-gas interfaces under working conditions are presented. As advancement of in situ spectroscopy an operando methodology for gas-liquid-solid reaction monitoring was developed that simultaneously combines catalytic activity and molecular level detection at the catalytically active site of the same sample. Semi-batch reactor conditions are achieved with the analytical set-up by implementing the ATR-IR flow-through cell in a recycle reactor system and integrating a specifically designed gas feeding system coupled with a bubble trap. By the usemore » of only one spectrometer the design of the new ATR-IR reactor cell allows for simultaneous detection of the bulk liquid and the catalytic interface during the working reaction. Holding two internal reflection elements (IRE) the sample compartments of the horizontally movable cell are consecutively flushed with reaction solution and pneumatically actuated, rapid switching of the cell (<1 s) enables to quasi simultaneously follow the heterogeneously catalysed reaction at the catalytic interface on a catalyst-coated IRE and in the bulk liquid on a blank IRE. For a complex heterogeneous reaction, the asymmetric hydrogenation of 2,2,2-trifluoroacetophenone on chirally modified Pt catalyst the elucidation of catalytic activity/enantioselectivity coupled with simultaneous monitoring of the catalytic solid-liquid-gas interface is shown. Both catalytic activity and enantioselectivity are strongly dependent on the experimental conditions. The opportunity to gain improved understanding by coupling measurements of catalytic performance and spectroscopic detection is presented. In addition, the applicability of modulation excitation spectroscopy and phase-sensitive detection are demonstrated.« less

Testing the Feasibility of a Passive and Active Case Ascertainment System for Multiple Rare Conditions Simultaneously: The Experience in Three US States

PubMed Central

McDermott, Suzanne; Ruttenber, Margaret; Mann, Joshua; Smith, Michael G; Royer, Julie; Valdez, Rodolfo

2016-01-01

Background Owing to their low prevalence, single rare conditions are difficult to monitor through current state passive and active case ascertainment systems. However, such monitoring is important because, as a group, rare conditions have great impact on the health of affected individuals and the well-being of their caregivers. A viable approach could be to conduct passive and active case ascertainment of several rare conditions simultaneously. This is a report about the feasibility of such an approach. Objective To test the feasibility of a case ascertainment system with passive and active components aimed at monitoring 3 rare conditions simultaneously in 3 states of the United States (Colorado, Kansas, and South Carolina). The 3 conditions are spina bifida, muscular dystrophy, and fragile X syndrome. Methods Teams from each state evaluated the possibility of using current or modified versions of their local passive and active case ascertainment systems and datasets to monitor the 3 conditions. Together, these teams established the case definitions and selected the variables and the abstraction tools for the active case ascertainment approach. After testing the ability of their local passive and active case ascertainment system to capture all 3 conditions, the next steps were to report the number of cases detected actively and passively for each condition, to list the local barriers against the combined passive and active case ascertainment system, and to describe the experiences in trying to overcome these barriers. Results During the test period, the team from South Carolina was able to collect data on all 3 conditions simultaneously for all ages. The Colorado team was also able to collect data on all 3 conditions but, because of age restrictions in its passive and active case ascertainment system, it was able to report few cases of fragile X syndrome. The team from Kansas was able to collect data only on spina bifida. For all states, the implementation of an active component of the ascertainment system was problematic. The passive component appears viable with minor modifications. Conclusions Despite evident barriers, the joint passive and active case ascertainment of rare disorders using modified existing surveillance systems and datasets seems feasible, especially for systems that rely on passive case ascertainment. PMID:27574026

Simulated microsurgery monitoring using intraoperative multimodal surgical microscopy

NASA Astrophysics Data System (ADS)

Lee, Donghyun; Lee, Changho; Kim, Sehui; Zhou, Qifa; Kim, Jeehyun; Kim, Chulhong

2016-03-01

We have developed an intraoperative multimodal surgical microscopy system that provides simultaneous real-time enlarged surface views and subsurface anatomic information during surgeries by integrating spectral domain optical coherence tomography (SD-OCT), optical-resolution photoacoustic microscopy (OR-PAM), and conventional surgical microscopy. By sharing the same optical path, both OCT and PAM images were simultaneously acquired. Additionally, the custom-made needle-type transducer received the generated PA signals enabling convenient surgical operation without using a water bath. Using a simple augmented device, the OCT and PAM images were projected on the view plane of the surgical microscope. To quantify the performance of our system, we measured spatial resolutions of our system. Then, three microsurgery simulation and analysis were processed: (1) ex vivo needle tracking and monitoring injection of carbon particles in biological tissues, (2) in vivo needle tracking and monitoring injection of carbon particles in tumor-bearing mice, and (3) in vivo guiding of melanoma removal in melanoma-bearing mice. The results indicate that this triple modal system is useful for intraoperative purposes, and can potentially be a vital tool in microsurgeries.

Preparation and measurement of FBG-based length, temperature, and vibration sensors

NASA Astrophysics Data System (ADS)

Mikel, Bretislav; Helan, Radek; Buchta, Zdenek; Jelinek, Michal; Cip, Ondrej

2016-12-01

We present system of structure health measurement by optical fiber sensors based on fiber Bragg gratings. Our system is focused to additionally install to existing buildings. We prepared first set-up of the system to monitoring of the nuclear power plant containment shape deformation. The presented system can measure up to several tens of sensors simultaneously. Each sensor contains optical fiber grating to measurement of change of length and the other independed fiber grating to monitor the temperature and the other ineligible effects.

Portable Runway Intersection Display and Monitoring System

NASA Technical Reports Server (NTRS)

Elrod, Susan Vinz (Inventor); Dabney, Richard W. (Inventor)

2011-01-01

Systems, methods and apparatus are provided through which an apparatus located on an airfield provides information to pilots in aircraft on the ground and simultaneously gathers information on the motion and position of the aircraft for controllers.

A fabric wrist patch sensor for continuous and comprehensive monitoring of the cardiovascular system.

PubMed

Kwonjoon Lee; Kiseok Song; Taehwan Roh; Hoi-Jun Yoo

2016-08-01

The wrist patch-type ECG/APW sensor system is proposed for continuous and comprehensive monitoring of the patient's cardiovascular system. The wrist patch-type ECG/APW sensor system is consists of ECG/APW sensor, ECG/APW electrodes, and base station for real-time monitoring of the patient's status. The ECG/APW sensor and electrodes are composed of wrist patch, bandage-type ECG electrode and fabric APW electrode, respectively so that the patient's cardiovascular system can be continuously monitored in daily life with free hand-movement. Since the proposed wrist patchtype ECG/APW sensor simultaneously measures ECG/APW, the cardiac indicators, such as HR and PAT, can be extracted for comprehensive and accurate monitoring of the patient's cardiovascular system. The proposed wrist patch-type ECG/APW sensor system is successfully verified using the commercial PPG sensor (RP520) and demonstrated with the customized Android application on the smart phone.

Ambulatory monitoring of activities and motor symptoms in Parkinson's disease.

PubMed

Zwartjes, Daphne G M; Heida, Tjitske; van Vugt, Jeroen P P; Geelen, Jan A G; Veltink, Peter H

2010-11-01

Ambulatory monitoring of motor symptoms in Parkinsons disease (PD) can improve our therapeutic strategies, especially in patients with motor fluctuations. Previously published monitors usually assess only one or a few basic aspects of the cardinal motor symptoms in a laboratory setting. We developed a novel ambulatory monitoring system that provides a complete motor assessment by simultaneously analyzing current motor activity of the patient (e.g. sitting, walking) and the severity of many aspects related to tremor, bradykinesia, and hypokinesia. The monitor consists of a set of four inertial sensors. Validity of our monitor was established in seven healthy controls and six PD patients treated with deep brain stimulation (DBS) of the subthalamic nucleus. Patients were tested at three different levels of DBS treatment. Subjects were monitored while performing different tasks, including motor tests of the Unified Parkinsons Disease Rating Scale (UPDRS). Output of the monitor was compared to simultaneously recorded videos. The monitor proved very accurate in discriminating between several motor activities. Monitor output correlated well with blinded UPDRS ratings during different DBS levels. The combined analysis of motor activity and symptom severity by our PD monitor brings true ambulatory monitoring of a wide variety of motor symptoms one step closer..

Selective pelvic autonomic nerve stimulation with simultaneous intraoperative monitoring of internal anal sphincter and bladder innervation.

PubMed

Kneist, W; Kauff, D W; Koch, K P; Schmidtmann, I; Heimann, A; Hoffmann, K P; Lang, H

2011-01-01

Pelvic autonomic nerve preservation avoids postoperative functional disturbances. The aim of this feasibility study was to develop a neuromonitoring system with simultaneous intraoperative verification of internal anal sphincter (IAS) activity and intravesical pressure. 14 pigs underwent low anterior rectal resection. During intermittent bipolar electric stimulation of the inferior hypogastric plexus (IHP) and the pelvic splanchnic nerves (PSN), electromyographic signals of the IAS and manometry of the urinary bladder were observed simultaneously. Stimulation of IHP and PSN as well as simultaneous intraoperative monitoring could be realized with an adapted neuromonitoring device. Neurostimulation resulted in either bladder or IAS activation or concerted activation of both. Intravesical pressure increase as well as amplitude increase of the IAS neuromonitoring signal did not differ significantly between stimulation of IHP and PSN [6.0 cm H(2)O (interquartile range [IQR] 3.5-9.0) vs. 6.0 cm H(2)O (IQR 3.0-10.0) and 12.1 μV (IQR 3.0-36.7) vs. 40.1 μV (IQR 9.0-64.3)] (p > 0.05). Pelvic autonomic nerve stimulation with simultaneous intraoperative monitoring of IAS and bladder innervation is feasible. The method may enable neuromonitoring with increasing selectivity for pelvic autonomic nerve preservation. Copyright © 2011 S. Karger AG, Basel.

Simultaneously multiparametric spectroscopic monitoring of tissue viability in the brain and small intestine

NASA Astrophysics Data System (ADS)

Tolmasov, Michael; Barbiro-Michaely, Efrat; Mayevsky, Avraham

2007-02-01

Under body O II imbalance, the Autonomic Nervous System is responsible for redistribution of blood flow with preference to the most vital organs (brain, heart), while the less vital organs (intestine, GI tract) are hypoperfused. The aim of this study was to develop and use an animal model for real time monitoring of tissue viability in the brain, and the small intestine, under various levels of oxygen and blood supply. Male Wistar rats were anesthetized, the brain cortex and intestinal serosa were exposed and connected by optical fibers to the Multi-Site Multi-Parametric (MSMP) monitoring system. Tissue blood flow (TBF) and mitochondrial NADH redox state were monitored simultaneously in the two organs. The rats were subjected to short anoxia, 20 minutes hypoxia or epinephrine (2& 8μg/kg I.V.). Under oxygen deficiency, cerebral blood flow (CBF) was elevated, whereas intestinal TBF was reduced. Mitochondrial NADH was significantly elevated in both organs. Systemic injection of Adrenaline showed a dose-depended increase in systemic blood pressure and CBF response whereas, intestinal TBF similarly decreased in both doses. In addition, NADH was elevated (reduced form) in the intestine whereas oxidation was observed in the brain. In conclusion, our preliminary results may imply the ability of using of the MSMP for monitoring non-vital organs in order to detect early changes in the balance between oxygen supply and demand in the body.

MARVEL: A knowledge-based productivity enhancement tool for real-time multi-mission and multi-subsystem spacecraft operations

NASA Astrophysics Data System (ADS)

Schwuttke, Ursula M.; Veregge, John, R.; Angelino, Robert; Childs, Cynthia L.

1990-10-01

The Monitor/Analyzer of Real-time Voyager Engineering Link (MARVEL) is described. It is the first automation tool to be used in an online mode for telemetry monitoring and analysis in mission operations. MARVEL combines standard automation techniques with embedded knowledge base systems to simultaneously provide real time monitoring of data from subsystems, near real time analysis of anomaly conditions, and both real time and non-real time user interface functions. MARVEL is currently capable of monitoring the Computer Command Subsystem (CCS), Flight Data Subsystem (FDS), and Attitude and Articulation Control Subsystem (AACS) for both Voyager spacecraft, simultaneously, on a single workstation. The goal of MARVEL is to provide cost savings and productivity enhancement in mission operations and to reduce the need for constant availability of subsystem expertise.

New developments in automated biosensing from remote water quality stations and satellite data retrieval for resources management

NASA Astrophysics Data System (ADS)

Morgan, E. L.; Eagleson, K. W.; Hermann, R.; McCollough, N. D.

1981-05-01

Maintaining adequate water quality in a multipurpose drainage system becomes increasingly important as demands on resources become greater. Real-time water quality monitoring plays a crucial role in meeting this objective. In addition to remote automated physical monitoring, developments at the end of the 1970's allow simultaneous real-time measurements of fish breathing response to water quality changes. These advantages complement complex in-stream surveys typically carried out to evaluate the environmental quality of a system. Automated biosensing units having remote capabilities are designed to aid in the evaluation of subtle water quality changes contributing to undesirable conditions in a drainage basin. Using microprocessor-based monitors to measure fish breathing rates, the biosensing units are interfaced to a U.S. National Aeronautics and Space Administration (N.A.S.A.) remote data collection platform for National Oceanic and Atmospheric Administration (N.O.A.A.) GOES satellite retrieval and transmission of data. Simultaneously, multiparameter physical information is collected from site-specific locations and recovered in a similar manner. Real-time biological and physical data received at a data processing center are readily available for interpretation by resource managers. Management schemes incorporating real-time monitoring networks into on-going programs to simultaneously retrieve biological and physical data by satellite, radio and telephone cable give added advantages in maintaining water quality for multipurpose needs.

Detection, Identification, Location, and Remote Sensing using SAW RFID Sensor Tags

NASA Technical Reports Server (NTRS)

Barton, Richard J.

2009-01-01

In this presentation, we will consider the problem of simultaneous detection, identification, location estimation, and remote sensing for multiple objects. In particular, we will describe the design and testing of a wireless system capable of simultaneously detecting the presence of multiple objects, identifying each object, and acquiring both a low-resolution estimate of location and a high-resolution estimate of temperature for each object based on wireless interrogation of passive surface acoustic wave (SAW) radiofrequency identification (RFID) sensor tags affixed to each object. The system is being studied for application on the lunar surface as well as for terrestrial remote sensing applications such as pre-launch monitoring and testing of spacecraft on the launch pad and monitoring of test facilities. The system utilizes a digitally beam-formed planar receiving antenna array to extend range and provide direction-of-arrival information coupled with an approximate maximum-likelihood signal processing algorithm to provide near-optimal estimation of both range and temperature. The system is capable of forming a large number of beams within the field of view and resolving the information from several tags within each beam. The combination of both spatial and waveform discrimination provides the capability to track and monitor telemetry from a large number of objects appearing simultaneously within the field of view of the receiving array. In the presentation, we will summarize the system design and illustrate several aspects of the operational characteristics and signal structure. We will examine the theoretical performance characteristics of the system and compare the theoretical results with results obtained from experiments in both controlled laboratory environments and in the field.

Simultaneous acoustic and dielectric real time curing monitoring of epoxy systems

NASA Astrophysics Data System (ADS)

Gkikas, G.; Saganas, Ch.; Grammatikos, S. A.; Aggelis, D. G.; Paipetis, A. S.

2012-04-01

The attainment of structural integrity of the reinforcing matrix in composite materials is of primary importance for the final properties of the composite structure. The detailed monitoring of the curing process on the other hand is paramount (i) in defining the optimal conditions for the impregnation of the reinforcement by the matrix (ii) in limiting the effects of the exotherm produced by the polymerization reaction which create unwanted thermal stresses and (iii) in securing optimal behavior in matrix controlled properties, such as off axis or shear properties and in general the durability of the composite. Dielectric curing monitoring is a well known technique for distinguishing between the different stages of the polymerization of a typical epoxy system. The technique successfully predicts the gelation and the vitrification of the epoxy and has been extended for the monitoring of prepregs. Recent work has shown that distinct changes in the properties of the propagated sound in the epoxy which undergoes polymerization is as well directly related to the gelation and vitrification of the resin, as well as to the attainment of the final properties of the resin system. In this work, a typical epoxy is simultaneously monitored using acoustic and dielectric methods. The system is isothermally cured in an oven to avoid effects from the polymerization exotherm. Typical broadband sensors are employed for the acoustic monitoring, while flat interdigital sensors are employed for the dielectric scans. All stages of the polymerization process were successfully monitored and the validity of both methods was cross checked and verified.

Multi-parameter monitoring of electrical machines using integrated fibre Bragg gratings

NASA Astrophysics Data System (ADS)

Fabian, Matthias; Hind, David; Gerada, Chris; Sun, Tong; Grattan, Kenneth T. V.

2017-04-01

In this paper a sensor system for multi-parameter electrical machine condition monitoring is reported. The proposed FBG-based system allows for the simultaneous monitoring of machine vibration, rotor speed and position, torque, spinning direction, temperature distribution along the stator windings and on the rotor surface as well as the stator wave frequency. This all-optical sensing solution reduces the component count of conventional sensor systems, i.e., all 48 sensing elements are contained within the machine operated by a single sensing interrogation unit. In this work, the sensing system has been successfully integrated into and tested on a permanent magnet motor prototype.

Simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in humans and other animal models using a single light source

NASA Astrophysics Data System (ADS)

Dent, Paul; Tun, Sai Han; Fillioe, Seth; Deng, Bin; Satalin, Josh; Nieman, Gary; Wilcox, Kailyn; Searles, Quinn; Narsipur, Sri; Peterson, Charles M.; Goodisman, Jerry; Mostrom, James; Steinmann, Richard; Chaiken, J.

2018-02-01

We previously reported a new algorithm "PV[O]H" for continuous, noninvasive, in vivo monitoring of hematocrit changes in blood and have since shown its utility for monitoring in humans during 1) hemodialysis, 2) orthostatic perturbations and 3) during blood loss and fluid replacement in a rat model. We now show that the algorithm is sensitive to changes in hemoglobin oxygen saturation. We document the phenomenology of the effect and explain the effect using new results obtained from humans and rat models. The oxygen sensitivity derives from the differential absorption of autofluorescence originating in the static tissues by oxy and deoxy hemoglobin. Using this approach we show how to perform simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in mammals using a single light source. We suspect that monitoring of changes in this suite of vital signs can be provided with improved time response, sensitivity and precision compared to existing methodologies. Initial results also offer a more detailed glimpse into the systemic oxygen transport in the circulatory system of humans.

Satellite (IRLS) tracking of elk

NASA Technical Reports Server (NTRS)

Buechner, H. K.

1972-01-01

The practicability of tracking free roaming animals in natural environments by satellite systems is reported. Satellite systems combine continuous tracking with simultaneous monitoring of physiological and environmental parameters through a combination of radio tracking and biotelemetric ground systems that lead to a better understanding of animal behavior and migration patterns.

Simultaneous measurements of bulk moduli and particle dynamics in a sheared colloidal glass

NASA Astrophysics Data System (ADS)

Massa, Michael V.; Eisenmann, Christoph; Kim, Chanjoong; Weitz, David A.

2007-03-01

We present a novel study of glassy colloidal systems, using a stress-controlled rheometer in conjunction with a confocal microscope. This experimental setup combines the measurement of bulk moduli, using conventional rheology, with the ability to track the motion of individual particles, through confocal microscopy techniques. We explore the response of the system to applied shear, by simultaneously monitoring the macroscopic relaxation and microscopic particle dynamics, under conditions from the quiescent glass to a shear-melted liquid.

Method and system for monitoring and displaying engine performance parameters

NASA Technical Reports Server (NTRS)

Abbott, Terence S. (Inventor); Person, Lee H., Jr. (Inventor)

1988-01-01

The invention is believed a major improvement that will have a broad application in governmental and commercial aviation. It provides a dynamic method and system for monitoring and simultaneously displaying in easily scanned form the available, predicted, and actual thrust of a jet aircraft engine under actual operating conditions. The available and predicted thrusts are based on the performance of a functional model of the aircraft engine under the same operating conditions. Other critical performance parameters of the aircraft engine and functional model are generated and compared, the differences in value being simultaneously displayed in conjunction with the displayed thrust values. Thus, the displayed information permits the pilot to make power adjustments directly while keeping him aware of total performance at a glance of a single display panel.

Simultaneous measurements of absorption spectrum and refractive index in a microfluidic system.

PubMed

Helseth, Lars Egil

2012-02-13

The characterization of dyes in various solvents requires determination of the absorption spectrum of the dye as well as the refractive index of the solvent. Typically, the refractive index of the solvent and the absorption spectrum of the solute are measured using separate experimental setups where significant liquid volumes are required. In this work the first optical measurement system that is able to do simultaneous measurements of the refractive index of the solvent and the spectral properties of the solute in a microscopic volume is presented. The laser dye Rhodamine 6G in glycerol is investigated, and the refractive index of the solution is monitored using the interference pattern of the light scattered off the channel, while its spectral properties is found by monitoring reflected light from the channel.

Flow cytometer jet monitor system

DOEpatents

Van den Engh, Ger

1997-01-01

A direct jet monitor illuminates the jet of a flow cytometer in a monitor wavelength band which is substantially separate from the substance wavelength band. When a laser is used to cause fluorescence of the substance, it may be appropriate to use an infrared source to illuminate the jet and thus optically monitor the conditions within the jet through a CCD camera or the like. This optical monitoring may be provided to some type of controller or feedback system which automatically changes either the horizontal location of the jet, the point at which droplet separation occurs, or some other condition within the jet in order to maintain optimum conditions. The direct jet monitor may be operated simultaneously with the substance property sensing and analysis system so that continuous monitoring may be achieved without interfering with the substance data gathering and may be configured so as to allow the front of the analysis or free fall area to be unobstructed during processing.

Integrated System of Structural Health Monitoring and Intelligent Management for a Cable-Stayed Bridge

PubMed Central

Chen, Bin; Wang, Xu; Sun, Dezhang; Xie, Xu

2014-01-01

It is essential to construct structural health monitoring systems for large important bridges. Zhijiang Bridge is a cable-stayed bridge that was built recently over the Hangzhou Qiantang River (the largest river in Zhejiang Province). The length of Zhijiang Bridge is 478 m, which comprises an arched twin-tower space and a twin-cable plane structure. As an example, the present study describes the integrated system of structural health monitoring and intelligent management for Zhijiang Bridge, which comprises an information acquisition system, data management system, evaluation and decision-making system, and application service system. The monitoring components include the working environment of the bridge and various factors that affect bridge safety, such as the stress and strain of the main bridge structure, vibration, cable force, temperature, and wind speed. In addition, the integrated system includes a forecasting and decision-making module for real-time online evaluation, which provides warnings and makes decisions based on the monitoring information. From this, the monitoring information, evaluation results, maintenance decisions, and warning information can be input simultaneously into the bridge monitoring center and traffic emergency center to share the monitoring data, thereby facilitating evaluations and decision making using the system. PMID:25140342

Integrated system of structural health monitoring and intelligent management for a cable-stayed bridge.

PubMed

Chen, Bin; Wang, Xu; Sun, Dezhang; Xie, Xu

2014-01-01

It is essential to construct structural health monitoring systems for large important bridges. Zhijiang Bridge is a cable-stayed bridge that was built recently over the Hangzhou Qiantang River (the largest river in Zhejiang Province). The length of Zhijiang Bridge is 478 m, which comprises an arched twin-tower space and a twin-cable plane structure. As an example, the present study describes the integrated system of structural health monitoring and intelligent management for Zhijiang Bridge, which comprises an information acquisition system, data management system, evaluation and decision-making system, and application service system. The monitoring components include the working environment of the bridge and various factors that affect bridge safety, such as the stress and strain of the main bridge structure, vibration, cable force, temperature, and wind speed. In addition, the integrated system includes a forecasting and decision-making module for real-time online evaluation, which provides warnings and makes decisions based on the monitoring information. From this, the monitoring information, evaluation results, maintenance decisions, and warning information can be input simultaneously into the bridge monitoring center and traffic emergency center to share the monitoring data, thereby facilitating evaluations and decision making using the system.

A simultaneous multimodal imaging system for tissue functional parameters

NASA Astrophysics Data System (ADS)

Ren, Wenqi; Zhang, Zhiwu; Wu, Qiang; Zhang, Shiwu; Xu, Ronald

2014-02-01

Simultaneous and quantitative assessment of skin functional characteristics in different modalities will facilitate diagnosis and therapy in many clinical applications such as wound healing. However, many existing clinical practices and multimodal imaging systems are subjective, qualitative, sequential for multimodal data collection, and need co-registration between different modalities. To overcome these limitations, we developed a multimodal imaging system for quantitative, non-invasive, and simultaneous imaging of cutaneous tissue oxygenation and blood perfusion parameters. The imaging system integrated multispectral and laser speckle imaging technologies into one experimental setup. A Labview interface was developed for equipment control, synchronization, and image acquisition. Advanced algorithms based on a wide gap second derivative reflectometry and laser speckle contrast analysis (LASCA) were developed for accurate reconstruction of tissue oxygenation and blood perfusion respectively. Quantitative calibration experiments and a new style of skinsimulating phantom were designed to verify the accuracy and reliability of the imaging system. The experimental results were compared with a Moor tissue oxygenation and perfusion monitor. For In vivo testing, a post-occlusion reactive hyperemia (PORH) procedure in human subject and an ongoing wound healing monitoring experiment using dorsal skinfold chamber models were conducted to validate the usability of our system for dynamic detection of oxygenation and perfusion parameters. In this study, we have not only setup an advanced multimodal imaging system for cutaneous tissue oxygenation and perfusion parameters but also elucidated its potential for wound healing assessment in clinical practice.

SIMULTANEOUS B'V'R' MONITORING OF BL LACERTAE OBJECT S5 0716+714 AND DETECTION OF INTER-BAND TIME DELAY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu Jianghua; He Xiangtao; Boettcher, Markus

We present the results of our optical monitoring of the BL Lac object S5 0716+714 over seven nights in 2006 December. The monitoring was carried out simultaneously at three optical wavelengths with a novel photometric system. The object did not show large-amplitude internight variations during this period. Intranight variations were observed on four nights and probably on one more. Strong bluer-when-brighter chromatism was detected on both intranight and internight timescales. The intranight variation amplitude decreases in the wavelength sequence of B', R', and V'. Cross-correlation analyses revealed that the variability at the B' and V' bands leads that at themore » R' band by about 30 minutes on one night.« less

Metabolic cytometry: capillary electrophoresis with two-color fluorescence detection for the simultaneous study of two glycosphingolipid metabolic pathways in single primary neurons.

PubMed

Essaka, David C; Prendergast, Jillian; Keithley, Richard B; Palcic, Monica M; Hindsgaul, Ole; Schnaar, Ronald L; Dovichi, Norman J

2012-03-20

Metabolic cytometry is a form of chemical cytometry wherein metabolic cascades are monitored in single cells. We report the first example of metabolic cytometry where two different metabolic pathways are simultaneously monitored. Glycolipid catabolism in primary rat cerebella neurons was probed by incubation with tetramethylrhodamine-labeled GM1 (GM1-TMR). Simultaneously, both catabolism and anabolism were probed by coincubation with BODIPY-FL labeled LacCer (LacCer-BODIPY-FL). In a metabolic cytometry experiment, single cells were incubated with substrate, washed, aspirated into a capillary, and lysed. The components were separated by capillary electrophoresis equipped with a two-spectral channel laser-induced fluorescence detector. One channel monitored fluorescence generated by the metabolic products produced from GM1-TMR and the other monitored the metabolic products produced from LacCer-BODIPY-FL. The metabolic products were identified by comparison with the mobility of a set of standards. The detection system produced at least 6 orders of magnitude dynamic range in each spectral channel with negligible spectral crosstalk. Detection limits were 1 zmol for BODIPY-FL and 500 ymol for tetramethylrhodamine standard solutions.

Wireless sensing system for bridge condition assessment and health monitoring

NASA Astrophysics Data System (ADS)

Gangone, Michael V.; Whelan, Matthew J.; Janoyan, Kerop D.

2009-03-01

Discussed in this paper is the deployment of a universal and low-cost dense wireless sensor system for structural monitoring, load rating and condition assessment of bridges. The wireless sensor system developed is designed specifically for diagnostic bridge monitoring, providing independent conditioning for both accelerometers and strain transducers in addition to high-rate wireless data transmission. The system was field deployed on a three span simply supported bridge superstructure, where strain and acceleration measurements were obtained simultaneously and in realtime at critical locations under several loading conditions, providing reliable quantitative information as to the actual performance level of the bridge. Monitoring was also conducted as the bridge was subjected to various controlled damage scenarios on the final day of testing. Select cases of detected damage using strain and modal based analysis are presented.

A Wearable System for Real-Time Continuous Monitoring of Physical Activity

PubMed Central

2018-01-01

Over the last decades, wearable systems have gained interest for monitoring of physiological variables, promoting health, and improving exercise adherence in different populations ranging from elite athletes to patients. In this paper, we present a wearable system for the continuous real-time monitoring of respiratory frequency (fR), heart rate (HR), and movement cadence during physical activity. The system has been experimentally tested in the laboratory (by simulating the breathing pattern with a mechanical ventilator) and by collecting data from one healthy volunteer. Results show the feasibility of the proposed device for real-time continuous monitoring of fR, HR, and movement cadence both in resting condition and during activity. Finally, different synchronization techniques have been investigated to enable simultaneous data collection from different wearable modules. PMID:29849993

Comparison of diagnostic value using a small, single channel, P-wave centric sternal ECG monitoring patch with a standard 3-lead Holter system over 24 hours.

PubMed

Smith, Warren M; Riddell, Fiona; Madon, Morag; Gleva, Marye J

2017-03-01

To compare simultaneous recordings from an external patch system specifically designed to ensure better P-wave recordings and standard Holter monitor to determine diagnostic efficacy. Holter monitors are a mainstay of clinical practice, but are cumbersome to access and wear and P-wave signal quality is frequently inadequate. This study compared the diagnostic efficacy of the P-wave centric electrocardiogram (ECG) patch (Carnation Ambulatory Monitor) to standard 3-channel (leads V1, II, and V5) Holter monitor (Northeast Monitoring, Maynard, MA). Patients were referred to a hospital Holter clinic for standard clinical indications. Each patient wore both devices simultaneously and served as their own control. Holter and Patch reports were read in a blinded fashion by experienced electrophysiologists unaware of the findings in the other corresponding ECG recording. All patients, technicians, and physicians completed a questionnaire on comfort and ease of use, and potential complications. In all 50 patients, the P-wave centric patch recording system identified rhythms in 23 patients (46%) that altered management, compared to 6 Holter patients (12%), P<.001. The patch ECG intervals PR, QRS and QT correlated well with the Holter ECG intervals having correlation coefficients of 0.93, 0.86, and 0.94, respectively. Finally, 48 patients (96%) preferred wearing the patch monitor. A single-channel ambulatory patch ECG monitor, designed specifically to ensure that the P-wave component of the ECG be visible, resulted in a significantly improved rhythm diagnosis and avoided inaccurate diagnoses made by the standard 3-channel Holter monitor. Copyright © 2016 Elsevier Inc. All rights reserved.

Simultaneous trilateral communication based on three mutually coupled chaotic semiconductor lasers with optical feedback.

PubMed

Li, Qiliang; Lu, Shanshan; Bao, Qi; Chen, Dewang; Hu, Miao; Zeng, Ran; Yang, Guowei; Li, Shuqin

2018-01-10

In this paper, we propose a chaos-based scheme allowing for trilateral communication among three mutually coupled chaotic semiconductor lasers. The coupling through a partially transparent optical mirror between two lasers induces the chaotic dynamics. We numerically solve the delay rate equations of three lasers and demonstrate that the dynamics is completely synchronous. Herein, each laser is not only a transmitter but a receiver; three different messages are encoded by simultaneously modulating bias current of the three lasers. By monitoring the synchronization error between transmitter and receiver, and comparing the error with the message of the local laser, we can decipher the message of the sender. The investigation indicates that these messages introduced on the two ends of each link among three lasers can be simultaneously transmitted and restored, so the system can realize simultaneous trilateral communication. In this scheme, an eavesdropper can monitor the synchronization error, but one has no way to obtain the bits that are being sent, so the trilateral communication is secure.

Novel diode-based laser system for combined transcutaneous monitoring and computer-controlled intermittent treatment of jaundiced neonates

NASA Astrophysics Data System (ADS)

Hamza, Mostafa; El-Ahl, Mohammad H. S.; Hamza, Ahmad M.

2001-06-01

The high efficacy of laser phototherapy combined with transcutaneous monitoring of serum bilirubin provides optimum safety for jaundiced infants from the risk of bilirubin encephalopathy. In this paper the authors introduce the design and operating principles of a new laser system that can provide simultaneous monitoring and treatment of several jaundiced babies at one time. The new system incorporates diode-based laser sources oscillating at selected wavelengths to achieve both transcutaneous differential absorption measurements of bilirubin concentration in addition to the computer controlled intermittent laser therapy through a network of optical fibers. The detailed description and operating characteristics of this system are presented.

Optimal Design of Multitype Groundwater Monitoring Networks Using Easily Accessible Tools.

PubMed

Wöhling, Thomas; Geiges, Andreas; Nowak, Wolfgang

2016-11-01

Monitoring networks are expensive to establish and to maintain. In this paper, we extend an existing data-worth estimation method from the suite of PEST utilities with a global optimization method for optimal sensor placement (called optimal design) in groundwater monitoring networks. Design optimization can include multiple simultaneous sensor locations and multiple sensor types. Both location and sensor type are treated simultaneously as decision variables. Our method combines linear uncertainty quantification and a modified genetic algorithm for discrete multilocation, multitype search. The efficiency of the global optimization is enhanced by an archive of past samples and parallel computing. We demonstrate our methodology for a groundwater monitoring network at the Steinlach experimental site, south-western Germany, which has been established to monitor river-groundwater exchange processes. The target of optimization is the best possible exploration for minimum variance in predicting the mean travel time of the hyporheic exchange. Our results demonstrate that the information gain of monitoring network designs can be explored efficiently and with easily accessible tools prior to taking new field measurements or installing additional measurement points. The proposed methods proved to be efficient and can be applied for model-based optimal design of any type of monitoring network in approximately linear systems. Our key contributions are (1) the use of easy-to-implement tools for an otherwise complex task and (2) yet to consider data-worth interdependencies in simultaneous optimization of multiple sensor locations and sensor types. © 2016, National Ground Water Association.

Digital Pitch-And-Roll Monitor

NASA Technical Reports Server (NTRS)

Finley, Tom D.; Brown, Jeff; Campbell, Ryland

1991-01-01

Highly accurate inclinometer developed. Monitors both pitch and roll simultaneously and provides printed output on demand. Includes three mutually perpendicular accelerometers and signal-conditioning circuitry converting outputs of sensors to digital values of pitch and roll. In addition to wind-tunnel applications, system useful in any application involving steady-state, precise sensing of angles, such as calibration of robotic devices and positioners.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, T; Kim, D; Kang, S

Purpose: Abdominal compression is known to be effective but, often makes external-marker-based monitoring of breathing motion not feasible. In this study, we developed and evaluated a system that enables both abdominal compression and monitoring of residual abdominal motion simultaneously. The system can also provide visual-biofeedback capability. Methods: The system developed consists of a compression belt, an abdominal motion monitoring sensor (gas pressure sensor) and a visual biofeedback device. The compression belt was designed to be able to compress the frontal side of the abdomen. The pressure level of the belt is controlled by air volume and monitored in real timemore » using the gas pressure sensor. The system displays not only the real-time monitoring curve but also a guiding respiration model (e.g., a breath hold or shallow breathing curve) simultaneously on the head mounted display to help patients keep their breathing pattern as consistent as possible. Three healthy volunteers were enrolled in this pilot study and respiratory signals (pressure variations) were obtained both with and without effective abdominal compression to investigate the feasibility of the developed system. Two guidance patterns, breath hold and shallow breathing, were tested. Results: All volunteers showed smaller abdominal motion with compression (about 40% amplitude reduction compared to without compression). However, the system was able to monitor residual abdominal motion for all volunteers. Even under abdominal compression, in addition, it was possible to make the subjects successfully follow the guide patterns using the visual biofeedback system. Conclusion: The developed abdominal compression & respiratory guiding system was feasible for residual abdominal motion management. It is considered that the system can be used for a respiratory motion involved radiation therapy while maintaining the merit of abdominal compression. This work was supported by the Radiation Technology R&D program (No. 2013M2A2A7043498) and the Mid-career Researcher Program (2014R1A2A1A10050270) through the National Research Foundation of Korea funded by the Ministry of Science, ICT&Future Planning.« less

Storing Data and Video on One Tape

NASA Technical Reports Server (NTRS)

Nixon, J. H.; Cater, J. P.

1985-01-01

Microprocessor-based system originally developed for anthropometric research merges digital data with video images for storage on video cassette recorder. Combined signals later retrieved and displayed simultaneously on television monitor. System also extracts digital portion of stored information and transfers it to solid-state memory.

A TDR-Based Soil Moisture Monitoring System with Simultaneous Measurement of Soil Temperature and Electrical Conductivity

PubMed Central

Skierucha, Wojciech; Wilczek, Andrzej; Szypłowska, Agnieszka; Sławiński, Cezary; Lamorski, Krzysztof

2012-01-01

Elements of design and a field application of a TDR-based soil moisture and electrical conductivity monitoring system are described with detailed presentation of the time delay units with a resolution of 10 ps. Other issues discussed include the temperature correction of the applied time delay units, battery supply characteristics and the measurement results from one of the installed ground measurement stations in the Polesie National Park in Poland. PMID:23202009

Integrating physically based simulators with Event Detection Systems: Multi-site detection approach.

PubMed

Housh, Mashor; Ohar, Ziv

2017-03-01

The Fault Detection (FD) Problem in control theory concerns of monitoring a system to identify when a fault has occurred. Two approaches can be distinguished for the FD: Signal processing based FD and Model-based FD. The former concerns of developing algorithms to directly infer faults from sensors' readings, while the latter uses a simulation model of the real-system to analyze the discrepancy between sensors' readings and expected values from the simulation model. Most contamination Event Detection Systems (EDSs) for water distribution systems have followed the signal processing based FD, which relies on analyzing the signals from monitoring stations independently of each other, rather than evaluating all stations simultaneously within an integrated network. In this study, we show that a model-based EDS which utilizes a physically based water quality and hydraulics simulation models, can outperform the signal processing based EDS. We also show that the model-based EDS can facilitate the development of a Multi-Site EDS (MSEDS), which analyzes the data from all the monitoring stations simultaneously within an integrated network. The advantage of the joint analysis in the MSEDS is expressed by increased detection accuracy (higher true positive alarms and fewer false alarms) and shorter detection time. Copyright © 2016 Elsevier Ltd. All rights reserved.

Simultaneous application of two independent EIT devices for real-time multi-plane imaging.

PubMed

Schullcke, B; Krueger-Ziolek, S; Gong, B; Mueller-Lisse, U; Moeller, K

2016-09-01

Diagnosis and treatment of many lung diseases like cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD) could benefit from 3D ventilation information. Applying two EIT systems concurrently is a simple approach without specialized hardware that allows monitoring of regional changes of ventilation distribution inside the thorax at different planes with the high temporal resolution much valued in common single plane EIT. Effects of two simultaneously operated EIT devices on one subject were investigated to monitor rapid processes inside the thorax with a multi-plane approach. Results obtained by simulations with a virtual phantom and measurements with a phantom tank reveal that the distance of electrode planes has an important influence on the signal quality. Band-pass filters adapted according to the distance of the planes, can be used to reduce the crosstalk of the concurrent EIT systems. Besides simulations and phantom tank experiments measurements were also taken from a lung healthy volunteer to demonstrate the operation under realistic conditions. Reconstructed images indicate that it is possible to simultaneously visualize regional ventilation at different planes if settings of the EIT devices are chosen appropriately.

Portable Positron Measurement System (PPMS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akers, Doug

Portable Positron Measurement System (PPMS) is an automated, non-destructive inspection system based on positron annihilation, which characterizes a material's in situatomic-level properties during the manufacturing processes of formation, solidification, and heat treatment. Simultaneous manufacturing and quality monitoring now are possible. Learn more about the lab's project on our facebook site http://www.facebook.com/idahonationallaboratory.

Portable Positron Measurement System (PPMS)

ScienceCinema

None

2017-12-09

Portable Positron Measurement System (PPMS) is an automated, non-destructive inspection system based on positron annihilation, which characterizes a material's in situatomic-level properties during the manufacturing processes of formation, solidification, and heat treatment. Simultaneous manufacturing and quality monitoring now are possible. Learn more about the lab's project on our facebook site http://www.facebook.com/idahonationallaboratory.

Soldier-Based Assessment of a Dual-Row Tactor Display during Simultaneous Navigational and Robot-Monitoring Tasks

DTIC Science & Technology

2015-08-01

Navigational and Robot -Monitoring Tasks by Gina Pomranky-Hartnett, Linda R Elliott, Bruce JP Mortimer, Greg R Mort, Rodger A Pettitt, and Gary A...Tactor Display during Simultaneous Navigational and Robot -Monitoring Tasks by Gina Pomranky-Hartnett, Linda R Elliott, and Rodger A Pettitt...2014–31 March 2015 4. TITLE AND SUBTITLE Soldier-Based Assessment of a Dual-Row Tactor Display during Simultaneous Navigational and Robot -Monitoring

Monitoring industrial facilities using principles of integration of fiber classifier and local sensor networks

NASA Astrophysics Data System (ADS)

Korotaev, Valery V.; Denisov, Victor M.; Rodrigues, Joel J. P. C.; Serikova, Mariya G.; Timofeev, Andrey V.

2015-05-01

The paper deals with the creation of integrated monitoring systems. They combine fiber-optic classifiers and local sensor networks. These systems allow for the monitoring of complex industrial objects. Together with adjacent natural objects, they form the so-called geotechnical systems. An integrated monitoring system may include one or more spatially continuous fiber-optic classifiers based on optic fiber and one or more arrays of discrete measurement sensors, which are usually combined in sensor networks. Fiber-optic classifiers are already widely used for the control of hazardous extended objects (oil and gas pipelines, railways, high-rise buildings, etc.). To monitor local objects, discrete measurement sensors are generally used (temperature, pressure, inclinometers, strain gauges, accelerometers, sensors measuring the composition of impurities in the air, and many others). However, monitoring complex geotechnical systems require a simultaneous use of continuous spatially distributed sensors based on fiber-optic cable and connected local discrete sensors networks. In fact, we are talking about integration of the two monitoring methods. This combination provides an additional way to create intelligent monitoring systems. Modes of operation of intelligent systems can automatically adapt to changing environmental conditions. For this purpose, context data received from one sensor (e.g., optical channel) may be used to change modes of work of other sensors within the same monitoring system. This work also presents experimental results of the prototype of the integrated monitoring system.

Wireless plataforms for the monitoring of biomedical variables

NASA Astrophysics Data System (ADS)

Bianco, Román; Laprovitta, Agustín; Misa, Alberto; Toselli, Eduardo; Castagnola, Juan Luis

2007-11-01

The present paper aims to analyze and to compare two wireless platforms for the monitoring of biomedical variables. They must obtain the vital signals of the patients, transmit them through a radio frequency bond and centralize them for their process, storage and monitoring in real time. The implementation of this system permit us to obtain two important benefits; The patient will enjoy greater comfort during the internment, and the doctors will be able to know the state of the biomedical variables of each patient, in simultaneous form. In order to achieve the objective of this work, two communication systems for wireless transmissions data were developed and implemented. The CC1000 transceiver was used in the first system and the Bluetooth module was used in the other system.

The automated counting of beating rates in individual cultured heart cells.

PubMed

Collins, G A; Dower, R; Walker, M J

1981-12-01

The effect of drugs on the beating rate of cultured heart cells can be monitored in a number of ways. The simultaneous automated measurement of beating rates of a number of cells allows drug effects to be rapidly quantified. A photoresistive detector placed on a television image of a cell, when coupled to operational amplifiers, gives binary signals that can be processed by a microprocessor. On this basis, we have devised a system that is capable of simultaneously monitoring the individual beating of six single cultured heart cells. A microprocessor automatically processes data obtained under different experimental conditions and records it in suitable descriptive formats such as dose-response curves and double reciprocal plots.

A System for Studying Facial Nerve Function in Rats through Simultaneous Bilateral Monitoring of Eyelid and Whisker Movements

PubMed Central

Heaton, James T.; Kowaleski, Jeffrey M.; Bermejo, Roberto; Zeigler, H. Philip; Ahlgren, David J.; Hadlock, Tessa A.

2008-01-01

The occurrence of inappropriate co-contraction of facially innervated muscles in humans (synkinesis) is a common sequela of facial nerve injury and recovery. We have developed a system for studying facial nerve function and synkinesis in restrained rats using non-contact opto-electronic techniques that enable simultaneous bilateral monitoring of eyelid and whisker movements. Whisking is monitored in high spatio-temporal resolution using laser micrometers, and eyelid movements are detected using infrared diode and phototransistor pairs that respond to the increased reflection when the eyelids cover the cornea. To validate the system, eight rats were tested with multiple five-minute sessions that included corneal air puffs to elicit blink and scented air flows to elicit robust whisking. Four rats then received unilateral facial nerve section and were tested at weeks 3–6. Whisking and eye blink behavior occurred both spontaneously and under stimulus control, with no detectable difference from published whisking data. Proximal facial nerve section caused an immediate ipsilateral loss of whisking and eye blink response, but some ocular closures emerged due to retractor bulbi muscle function. The independence observed between whisker and eyelid control indicates that this system may provide a powerful tool for identifying abnormal co-activation of facial zones resulting from aberrant axonal regeneration. PMID:18442856

Delivery of Cancer Therapeutics Using Nanotechnology

PubMed Central

Lim, Eun-Kyung; Jang, Eunji; Lee, Kwangyeol; Haam, Seungjoo; Huh, Yong-Min

2013-01-01

Nanoparticles have been investigated as drug carriers, because they provide a great opportunity due to their advantageous features: (i) various formulations using organic/inorganic materials, (ii) easy modification of targeting molecules, drugs or other molecules on them, (iii) effective delivery to target sites, resulting in high therapeutic efficacy and (iv) controlling drug release by external/internal stimuli. Because of these features, therapeutic efficacy can be improved and unwanted side effects can be reduced. Theranostic nanoparticles have been developed by incorporating imaging agents in drug carriers as all-in-one system, which makes it possible to diagnose and treat cancer by monitoring drug delivery behavior simultaneously. Recently, stimuli-responsive, activatable nanomaterials are being applied that are capable of producing chemical or physical changes by external stimuli. By using these nanoparticles, multiple tasks can be carried out simultaneously, e.g., early and accurate diagnosis, efficient cataloguing of patient groups of personalized therapy and real-time monitoring of disease progress. In this paper, we describe various types of nanoparticles for drug delivery systems, as well as theranostic systems. PMID:24300452

USMC UGS technology advancements

NASA Astrophysics Data System (ADS)

Hartup, David C.; Barr, Michael E.; Hirz, Philip M.; Kipp, Jason; Fishburn, Thomas A.; Waller, Ezra S.; Marks, Brian A.

2008-04-01

Technology advancements for the USMC UGS system are described. Integration of the ARL Blue Radio/CSR into the System Controller and Radio Repeater permit the TRSS system to operate seamlessly within the Family of UGS concept. In addition to the Blue Radio/CSR, the TRSS system provides VHF and SATCOM radio links. The TRSS system is compatible with a wide range of imagers, including those with both analog and digital interfaces. The TRSS System Controller permits simultaneous monitoring of 2 camera inputs. To complement enhanced compatibility and improved processing, the mechanical housing of the TRSS System Controller has been updated. The SDR-II, a system monitoring device, also incorporates four Blue Radio/CSRs along with other communication capabilities, making it an ideal choice for a monitoring station within the Family of UGS. Field testing of L-3 Nova's UGS system at YPG has shown flawless performance, capturing all 126 targets.

Water quality monitoring of Jialing-River in Chongqing using advanced ion chromatographic system.

PubMed

Tanaka, Kazuhiko; Shi, Chao-Hong; Nakagoshi, Nobukazu

2012-04-01

The water quality monitoring operation to evaluate the water quality of polluted river is an extremely important task for the river-watershed management/control based on the environmental policy. In this study, the novel, simple and convenient water quality monitoring of Jialing-River in Chongqing, China was carried out using an advanced ion chromatography (IC) consisting of ion-exclusion/cation-exchange chromatography (IEC/CEC) with conductivity detection for determining simultaneously the common anions such as SO4(2-), Cl(-), and NO3(-) and the cations such as Na+, NH4+, K+, Mg2+, and Ca2+, the ion-exclusion chromatography (IEC) with visible detection for determining simultaneously the nutrient components such as phosphate and silicate ions, and the IEC with the enhanced conductivity detection using a post column of K+-form cation-exchange resin for determining HCO3(-)-alkalinity as an inorganic-carbon source for biomass synthesis in biological reaction process under the aerobic conditions. According to the ionic balance theory between the total equivalent concentrations of anions and cations, the water quality evaluation of the Jialing-River waters taking at different sampling sites in Chongqing metropolitan area was carried out using the advanced IC system. As a result, the effectiveness of this novel water quality monitoring methodology using the IC system was demonstrated on the several practical applications to a typical biological sewage treatment plant on Jialing-River of Chongqing.

Implementation of in-line infrared monitor in full-scale anaerobic digestion process.

PubMed

Spanjers, H; Bouvier, J C; Steenweg, P; Bisschops, I; van Gils, W; Versprille, B

2006-01-01

During start up but also during normal operation, anaerobic reactor systems should be run and monitored carefully to secure trouble-free operation, because the process is vulnerable to disturbances such as temporary overloading, biomass wash out and influent toxicity. The present method of monitoring is usually by manual sampling and subsequent laboratory analysis. Data collection, processing and feedback to system operation is manual and ad hoc, and involves high-level operator skills and attention. As a result, systems tend to be designed at relatively conservative design loading rates resulting in significant over-sizing of reactors and thus increased systems cost. It is therefore desirable to have on-line and continuous access to performance data on influent and effluent quality. Relevant variables to indicate process performance include VFA, COD, alkalinity, sulphate, and, if aerobic post-treatment is considered, total nitrogen, ammonia and nitrate. Recently, mid-IR spectrometry was demonstrated on a pilot scale to be suitable for in-line simultaneous measurement of these variables. This paper describes a full-scale application of the technique to test its ability to monitor continuously and without human intervention the above variables simultaneously in two process streams. For VFA, COD, sulphate, ammonium and TKN good agreement was obtained between in-line and manual measurements. During a period of six months the in-line measurements had to be interrupted several times because of clogging. It appeared that the sample pre-treatment unit was not able to cope with high solids concentrations all the time.

Room air monitor for radioactive aerosols

DOEpatents

Balmer, D.K.; Tyree, W.H.

1987-03-23

A housing assembly for use with a room air monitor for simultaneous collection and counting of suspended particles includes a casing containing a combination detector-preamplifier system at one end, a filter system at the other end, and an air flow system consisting of an air inlet formed in the casing between the detector-preamplifier system and the filter system and an air passageway extending from the air inlet through the casing and out the end opposite the detector-preamplifier combination. The filter system collects suspended particles transported directly through the housing by means of the air flow system, and these particles are detected and examined for radioactivity by the detector-preamplifier combination. 2 figs.

ANITA Air Monitoring on the International Space Station: Results Compared to Other Measurements

NASA Technical Reports Server (NTRS)

Honne, A.; Schumann-Olsen, H.; Kaspersen, K.; Limero, T.; Macatangay, A.; Mosebach, H.; Kampf, D.; Mudgett, P. D.; James, J. T.; Tan, G.;

Remote Diagnosis of the International Space Station Utilizing Telemetry Data

NASA Technical Reports Server (NTRS)

Deb, Somnath; Ghoshal, Sudipto; Malepati, Venkat; Domagala, Chuck; Patterson-Hine, Ann; Alena, Richard; Norvig, Peter (Technical Monitor)

2000-01-01

Modern systems such as fly-by-wire aircraft, nuclear power plants, manufacturing facilities, battlefields, etc., are all examples of highly connected network enabled systems. Many of these systems are also mission critical and need to be monitored round the clock. Such systems typically consist of embedded sensors in networked subsystems that can transmit data to central (or remote) monitoring stations. Moreover, many legacy are safety systems were originally not designed for real-time onboard diagnosis, but a critical and would benefit from such a solution. Embedding additional software or hardware in such systems is often considered too intrusive and introduces flight safety and validation concerns. Such systems can be equipped to transmit the sensor data to a remote-processing center for continuous health monitoring. At Qualtech Systems, we are developing a Remote Diagnosis Server (RDS) that can support multiple simultaneous diagnostic sessions from a variety of remote subsystems.

Evaluating the performance of a 50 kilowatt grid-connected photovoltaic system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chowdhury, B.H.; Muknahallipatn, S.; Cupal, J.J.

A 50-kilowatt solar photovoltaic (PV) system was built at the University of Wyoming (UW) in 1996. The system comprises of three sub-systems. The first sub-system, a 10 kW roof-integrated system is located on the roof of the Engineering Building. The second sub-system is a 5 kW rack-mounted, ballasted PV system located on another part of the roof. The third sub-system is a 35 kW shade structure and is located adjacent to the university's football stadium. The three sub-systems differ in their design strategy since each is being used for research and education at the university. Each sub-system, being located atmore » some distance away from one another, supplies a different part of the campus grid. Efforts are continuing for setting up a central monitoring system, which will receive data remotely from all locations. A part of this monitoring system is complete. The system as configured provides a great deal of flexibility, which is in turn demanded by the variety of signal types measured at each installation. Each installation requires measurement of multiple dc and ac voltages and currents and one slowly varying voltage (proportional to solar insolation). The simultaneous sampling, fast sample rate, and lowpass signal conditioning allow for accurate measurement of power factor and total harmonic distortion of the inverter outputs. Panel and inverter efficiencies can be determined via simultaneous DC and AC measurements. These performance monitors provide the essential data for characterization of the PV effect at the grid input, and enable the use of intelligent power factor correction and harmonic filtering. Monitoring of the system shows that the total harmonic distortion present in the ac power output is at or below the acceptable limit as recommended by IEEE 519-1992. The harmonic distortion worsens when the ac power reaches more than 3.8 kW. A number of reliability problems with PV modules and inverters have delayed full functionality of the system.« less

Design for Run-Time Monitor on Cloud Computing

NASA Astrophysics Data System (ADS)

Kang, Mikyung; Kang, Dong-In; Yun, Mira; Park, Gyung-Leen; Lee, Junghoon

Cloud computing is a new information technology trend that moves computing and data away from desktops and portable PCs into large data centers. The basic principle of cloud computing is to deliver applications as services over the Internet as well as infrastructure. A cloud is the type of a parallel and distributed system consisting of a collection of inter-connected and virtualized computers that are dynamically provisioned and presented as one or more unified computing resources. The large-scale distributed applications on a cloud require adaptive service-based software, which has the capability of monitoring the system status change, analyzing the monitored information, and adapting its service configuration while considering tradeoffs among multiple QoS features simultaneously. In this paper, we design Run-Time Monitor (RTM) which is a system software to monitor the application behavior at run-time, analyze the collected information, and optimize resources on cloud computing. RTM monitors application software through library instrumentation as well as underlying hardware through performance counter optimizing its computing configuration based on the analyzed data.

Multilevel semantic analysis and problem-solving in the flight domain

NASA Technical Reports Server (NTRS)

Chien, R. T.; Chen, D. C.; Ho, W. P. C.; Pan, Y. C.

1982-01-01

A computer based cockpit system which is capable of assisting the pilot in such important tasks as monitoring, diagnosis, and trend analysis was developed. The system is properly organized and is endowed with a knowledge base so that it enhances the pilot's control over the aircraft while simultaneously reducing his workload.

Simultaneous and quantitative monitoring of co-cultured Pseudomonas aeruginosa and Staphylococcus aureus with antibiotics on a diffusometric platform

NASA Astrophysics Data System (ADS)

Chung, Chih-Yao; Wang, Jhih-Cheng; Chuang, Han-Sheng

2017-04-01

Successful treatments against bacterial infections depend on antimicrobial susceptibility testing (AST). However, conventional AST requires more than 24 h to obtain an outcome, thereby contributing to high patient mortality. An antibiotic therapy based on experiences is therefore necessary for saving lives and escalating the emergence of multidrug-resistant pathogens. Accordingly, a fast and effective drug screen is necessary for the appropriate administration of antibiotics. The mixed pathogenic nature of infectious diseases emphasizes the need to develop an assay system for polymicrobial infections. On this basis, we present a novel technique for simultaneous and quantitative monitoring of co-cultured microorganisms by coupling optical diffusometry with bead-based immunoassays. This simple integration simultaneously achieves a rapid AST analysis for two pathogens. Triple color particles were simultaneously recorded and subsequently analyzed by functionalizing different fluorescent color particles with dissimilar pathogen-specific antibodies. Results suggested that the effect of the antibiotic, gentamicin, on co-cultured Pseudomonas aeruginosa and Staphylococcus aureus was effectively distinguished by the proposed technique. This study revealed a multiplexed and time-saving (within 2 h) platform with a small sample volume (~0.5 μL) and a low initial bacterial count (50 CFU per droplet, ~105 CFU/mL) for continuously monitoring the growth of co-cultured microorganisms. This technique provides insights into timely therapies against polymicrobial diseases in the near future.

Errors Recruit both Cognitive and Emotional Monitoring Systems: Simultaneous Intracranial Recordings in the Dorsal Anterior Cingulate Gyrus and Amygdala Combined with fMRI

ERIC Educational Resources Information Center

Pourtois, Gilles; Vocat, Roland; N'Diaye, Karim; Spinelli, Laurent; Seeck, Margitta; Vuilleumier, Patrik

2010-01-01

We studied error monitoring in a human patient with unique implantation of depth electrodes in both the left dorsal cingulate gyrus and medial temporal lobe prior to surgery. The patient performed a speeded go/nogo task and made a substantial number of commission errors (false alarms). As predicted, intracranial Local Field Potentials (iLFPs) in…

Development of a New ICT-Based Multisensor Blood Pressure Monitoring System for Use in Hemodynamic Biomarker-Initiated Anticipation Medicine for Cardiovascular Disease: The National IMPACT Program Project.

PubMed

Kario, Kazuomi; Tomitani, Naoko; Kanegae, Hiroshi; Yasui, Nobuhiko; Nishizawa, Masafumi; Fujiwara, Takeshi; Shigezumi, Takeya; Nagai, Ryozo; Harada, Hiroshi

We have developed a multisensor home and ambulatory blood pressure (BP) monitoring system for monitoring 24-h central and brachial BP variability concurrent with physical activity (PA), temperature, and atmospheric pressure. The new BP monitoring system utilizes our recently developed biological and environmental signal monitoring Information Communication Technology/Internet of Things system, which can simultaneously monitor the environment (temperature, illumination, etc.) of different rooms in a house (entryway, bedroom, living room, bathing room, and toilet), and a wrist-type high-sensitivity actigraph for identifying the location of patients. By collecting both data on BP and environmental parameters, the system can assess the brachial and central hemodynamic BP reactivity profiles of patients, such as actisensitivity (BP change with PA), thermosensitivity (with temperature), and atmospheric sensitivity (with atmospheric pressure). We used this new system to monitor ambulatory BP variability in outpatients with one or more cardiovascular disease (CVD) risk factors both in summer and winter. Actisensitivity (the slope of the regression line of ambulatory BP against the log-physical activity) was higher in winter than summer. By multi-level analysis using the parameters monitored by this system, we estimated the ambulatory BPs under different conditions. The individual time-series big data collected by this system will contribute to anticipation medicine for CVD. Copyright © 2017 Elsevier Inc. All rights reserved.

Pseudotachometer for mobile metabolic analyzer

NASA Technical Reports Server (NTRS)

Currie, J. R.

1974-01-01

Metabolic analyzer determines a patient's walking or ambulation speed and simultaneously measures his metabolic parameters. Analyzer is designed to move at some preselected human ambulation speed. During test, patient is connected to system and follows analyzer closely while his metabolic data is being monitored.

Fiber optic system for deflection and damage detection in morphing wing structures

NASA Astrophysics Data System (ADS)

Scheerer, M.; Djinovic, Z.; Schüller, M.

2013-04-01

Within the EC Clean Sky - Smart Fixed Wing Aircraft initiative concepts for actuating morphing wing structures are under development. In order for developing a complete integrated system including the actuation, the structure to be actuated and the closed loop control unit a hybrid deflection and damage monitoring system is required. The aim of the project "FOS3D" is to develop and validate a fiber optic sensing system based on low-coherence interferometry for simultaneous deflection and damage monitoring. The proposed system uses several distributed and multiplexed fiber optic Michelson interferometers to monitor the strain distribution over the actuated part. In addition the same sensor principle will be used to acquire and locate the acoustic emission signals originated from the onset and growth of defects like impact damages, cracks and delamination's. Within this paper the authors present the concept, analyses and first experimental results of the mentioned system.

A Fully Redundant On-Line Mass Spectrometer System Used to Monitor Cryogenic Fuel Leaks on the Space Shuttle

NASA Technical Reports Server (NTRS)

Griffin, Timothy P.; Naylor, Guy R.; Haskell, William D.; Breznik, Greg S.; Mizell, Carolyn A.; Helms, William R.; Steinrock, T. (Technical Monitor)

2001-01-01

An on-line gas monitoring system was developed to replace the older systems used to monitor for cryogenic leaks on the Space Shuttles before launch. The system uses a mass spectrometer to monitor multiple locations in the process, which allows the system to monitor all gas constituents of interest in a nearly simultaneous manner. The system is fully redundant and meets all requirements for ground support equipment (GSE). This includes ruggedness to withstand launch on the Mobile Launcher Platform (MLP), ease of operation, and minimal operator intervention. The system can be fully automated so that an operator is notified when an unusual situation or fault is detected. User inputs are through personal computer using mouse and keyboard commands. The graphical user interface is very intuitive and easy to operate. The system has successfully supported four launches to date. It is currently being permanently installed as the primary system monitoring the Space Shuttles during ground processing and launch operations. Time and cost savings will be substantial over the current systems when it is fully implemented in the field. Tests were performed to demonstrate the performance of the system. Low limits-of-detection coupled with small drift make the system a major enhancement over the current systems. Though this system is currently optimized for detecting cryogenic leaks, many other gas constituents could be monitored using the Hazardous Gas Detection System (HGDS) 2000.

Health monitoring of prestressing tendons in post-tensioned concrete structures

NASA Astrophysics Data System (ADS)

Salamone, Salvatore; Bartoli, Ivan; Nucera, Claudio; Phillips, Robert; Lanza di Scalea, Francesco

2011-04-01

Currently 90% of bridges built in California are post-tensioned box-girder. In such structures the steel tendons are the main load-carrying components. The loss of prestress, as well as the presence of defects or the tendon breakage, can be catastrophic for the entire structure. Unfortunately, today there is no well-established method for the monitoring of prestressing (PS) tendons that can provide simultaneous information related to the presence of defects and the level of prestress in a continuous, real time manner. If such a monitoring system were available, considerable savings would be achieved in bridge maintenance since repairs would be implemented in a timely manner without traffic disruptions. This paper presents a health monitoring system for PS tendons in post-tensioned structures of interest to Caltrans. Such a system uses ultrasonic guided waves and embedded sensors to provide simultaneously and in real time, (a) measurements of the level of applied prestress, and (b) defect detection at early grow stages. The proposed PS measurement technique exploits the sensitivity of ultrasonic waves to the inter-wire contact developing in a multi-wire strand as a function of prestress level. In particular the nonlinear ultrasonic behavior of the tendon under changing levels of prestress is monitored by tracking higher-order harmonics at (nω) arising under a fundamental guided-wave excitation at (ω). Moreover this paper also present real-time damage detection and location in post-tensioned bridge joints using Acoustic Emission techniques. Experimental tests on large-scale single-tendon PT joint specimens, subjected to multiple load cycles, will be presented to validate the monitoring of PS loads (through nonlinear ultrasonic probing) and the monitoring of damage progression and location (through acoustic emission techniques). Issues and potential for the use of such techniques to monitor post-tensioned bridges in the field will be discussed.

[Personal computer-based computer monitoring system of the anesthesiologist (2-year experience in development and use)].

PubMed

Buniatian, A A; Sablin, I N; Flerov, E V; Mierbekov, E M; Broĭtman, O G; Shevchenko, V V; Shitikov, I I

1995-01-01

Creation of computer monitoring systems (CMS) for operating rooms is one of the most important spheres of personal computer employment in anesthesiology. The authors developed a PC RS/AT-based CMS and effectively used it for more than 2 years. This system permits comprehensive monitoring in cardiosurgical operations by real time processing the values of arterial and central venous pressure, pressure in the pulmonary artery, bioelectrical activity of the brain, and two temperature values. Use of this CMS helped appreciably improve patients' safety during surgery. The possibility to assess brain function by computer monitoring the EEF simultaneously with central hemodynamics and body temperature permit the anesthesiologist to objectively assess the depth of anesthesia and to diagnose cerebral hypoxia. Automated anesthesiological chart issued by the CMS after surgery reliably reflects the patient's status and the measures taken by the anesthesiologist.

A PC-based bus monitor program for use with the transport systems research vehicle RS-232 communication interfaces

NASA Technical Reports Server (NTRS)

Easley, Wesley C.

1991-01-01

Experiment critical use of RS-232 data busses in the Transport Systems Research Vehicle (TSRV) operated by the Advanced Transport Operating Systems Program Office at the NASA Langley Research Center has recently increased. Each application utilizes a number of nonidentical computer and peripheral configurations and requires task specific software development. To aid these development tasks, an IBM PC-based RS-232 bus monitoring system was produced. It can simultaneously monitor two communication ports of a PC or clone, including the nonstandard bus expansion of the TSRV Grid laptop computers. Display occurs in a separate window for each port's input with binary display being selectable. A number of other features including binary log files, screen capture to files, and a full range of communication parameters are provided.

INTERCOMPARISON OF PERIODIC FINE PARTICLE SULFUR AND SULFATE CONCENTRATION RESULTS

EPA Science Inventory

A one-week study was conducted in August 1979 to evaluate the comparative ability of representative aerosol sampling systems to monitor fine particulate sulfur and sulfate concentrations periodically in situ. Participants in the study operated their samplers simultaneously in the...

Validating the Equilibrium Stage Model for an Azeotropic System in a Laboratorial Distillation Column

ERIC Educational Resources Information Center

Duarte, B. P. M.; Coelho Pinheiro, M. N.; Silva, D. C. M.; Moura, M. J.

2006-01-01

The experiment described is an excellent opportunity to apply theoretical concepts of distillation, thermodynamics of mixtures and process simulation at laboratory scale, and simultaneously enhance the ability of students to operate, control and monitor complex units.

A head-mounted display-based personal integrated-image monitoring system for transurethral resection of the prostate.

PubMed

Yoshida, Soichiro; Kihara, Kazunori; Takeshita, Hideki; Fujii, Yasuhisa

2014-12-01

The head-mounted display (HMD) is a new image monitoring system. We developed the Personal Integrated-image Monitoring System (PIM System) using the HMD (HMZ-T2, Sony Corporation, Tokyo, Japan) in combination with video splitters and multiplexers as a surgical guide system for transurethral resection of the prostate (TURP). The imaging information obtained from the cystoscope, the transurethral ultrasonography (TRUS), the video camera attached to the HMD, and the patient's vital signs monitor were split and integrated by the PIM System and a composite image was displayed by the HMD using a four-split screen technique. Wearing the HMD, the lead surgeon and the assistant could simultaneously and continuously monitor the same information displayed by the HMD in an ergonomically efficient posture. Each participant could independently rearrange the images comprising the composite image depending on the engaging step. Two benign prostatic hyperplasia (BPH) patients underwent TURP performed by surgeons guided with this system. In both cases, the TURP procedure was successfully performed, and their postoperative clinical courses had no remarkable unfavorable events. During the procedure, none of the participants experienced any HMD-wear related adverse effects or reported any discomfort.

The GBT-SCA, a radiation tolerant ASIC for detector control and monitoring applications in HEP experiments

NASA Astrophysics Data System (ADS)

Caratelli, A.; Bonacini, S.; Kloukinas, K.; Marchioro, A.; Moreira, P.; De Oliveira, R.; Paillard, C.

2015-03-01

The future upgrades of the LHC experiments will increase the beam luminosity leading to a corresponding growth of the amounts of data to be treated by the data acquisition systems. To address these needs, the GBT (Giga-Bit Transceiver optical link [1,2]) architecture was developed to provide the simultaneous transfer of readout data, timing and trigger signals as well as slow control and monitoring data. The GBT-SCA ASIC, part of the GBT chip-set, has the purpose to distribute control and monitoring signals to the on-detector front-end electronics and perform monitoring operations of detector environmental parameters. In order to meet the requirements of different front-end ASICs used in the experiments, it provides various user-configurable interfaces capable to perform simultaneous operations. It is designed employing radiation tolerant design techniques to ensure robustness against SEUs and TID radiation effects and is implemented in a commercial 130 nm CMOS technology. This work presents the GBT-SCA architecture, the ASIC interfaces, the data transfer protocol, and its integration with the GBT optical link.

An inductively powered telemetry system for temperature, EKG, and activity monitoring

NASA Technical Reports Server (NTRS)

Fryer, T. B.; Lund, G. F.; Williams, B. A.

1978-01-01

An implant telemetry system for the simultaneous monitoring of temperature, activity, and EKG from small animals, such as rats, was designed with the feature that instead of a battery the system is energized by an inductive field. A 250 kHz resonant coil surrounds the cage (30 x 30 x 20 cm) and provides the approximately 100 microns of power required to operate the implant transmitter while allowing the animal unrestrained movement in the cage. The implant can also be battery operated if desired. RF transmission is in the 8-10 MHz band, which allows the use of a simple, essentially single IC chip, receiver.

An inductively powered telemetry system for temperature, EKG, and activity monitoring

NASA Technical Reports Server (NTRS)

Fryer, T. B.; Lund, G. F.; Williams, B. A.

1978-01-01

An implant telemetry system for the simultaneous monitoring of temperature, activity, and EKG from small animals, such as rats, has recently been designed with the novel feature that instead of a battery the system is energized by an inductive field. A 250 kHz resonant coil surrounds the cage (30 x 30 x 20 cm) and provides the approximately 100 microwatt of power required to operate the implant transmitter while allowing the animal unrestrained movement in the cage. The implant can also be battery operated if desired. RF transmission is in the 8-10 MHz band, which allows the use of a simple, essentially single IC chip, receiver.

Analytical validation applied to simultaneous determination of solvents dichloromethane (DCM), methyl isobutyl ketone (MIBK), tetrahydrofuran (THF) and toluene (TOL) in urine by headspace extraction and injection on chromatographic system with a flame ionization detector

NASA Astrophysics Data System (ADS)

Muna, E. D. M.; Pereira, R. P.

2016-07-01

The determination of the volatile organic solvents dichloromethane (DCM), methyl isobutyl ketone (MIBK), tetrahydrofuran (THF) and toluene (TOL) is applied on toxicological monitoring of employees in various industrial activities. The gas chromatography technique with flame ionization detector and headspace injection system has been applied. The analytical procedure developed allows the simultaneous determination of the above-mentioned solvents and the accuracy of the method was tested following the INMETRO guidelines through the DOQ-CGRE 008 Rev.04-July/2011.

R2U2: Monitoring and Diagnosis of Security Threats for Unmanned Aerial Systems

NASA Technical Reports Server (NTRS)

Schumann, Johann; Moosbruger, Patrick; Rozier, Kristin Y.

2015-01-01

We present R2U2, a novel framework for runtime monitoring of security properties and diagnosing of security threats on-board Unmanned Aerial Systems (UAS). R2U2, implemented in FPGA hardware, is a real-time, REALIZABLE, RESPONSIVE, UNOBTRUSIVE Unit for security threat detection. R2U2 is designed to continuously monitor inputs from the GPS and the ground control station, sensor readings, actuator outputs, and flight software status. By simultaneously monitoring and performing statistical reasoning, attack patterns and post-attack discrepancies in the UAS behavior can be detected. R2U2 uses runtime observer pairs for linear and metric temporal logics for property monitoring and Bayesian networks for diagnosis of security threats. We discuss the design and implementation that now enables R2U2 to handle security threats and present simulation results of several attack scenarios on the NASA DragonEye UAS.

A fully automated health-care monitoring at home without attachment of any biological sensors and its clinical evaluation.

PubMed

Motoi, Kosuke; Ogawa, Mitsuhiro; Ueno, Hiroshi; Kuwae, Yutaka; Ikarashi, Akira; Yuji, Tadahiko; Higashi, Yuji; Tanaka, Shinobu; Fujimoto, Toshiro; Asanoi, Hidetsugu; Yamakoshi, Ken-ichi

2009-01-01

Daily monitoring of health condition is important for an effective scheme for early diagnosis, treatment and prevention of lifestyle-related diseases such as adiposis, diabetes, cardiovascular diseases and other diseases. Commercially available devices for health care monitoring at home are cumbersome in terms of self-attachment of biological sensors and self-operation of the devices. From this viewpoint, we have been developing a non-conscious physiological monitor installed in a bath, a lavatory, and a bed for home health care and evaluated its measurement accuracy by simultaneous recordings of a biological sensors directly attached to the body surface. In order to investigate its applicability to health condition monitoring, we have further developed a new monitoring system which can automatically monitor and store the health condition data. In this study, by evaluation on 3 patients with cardiac infarct or sleep apnea syndrome, patients' health condition such as body and excretion weight in the toilet and apnea and hypopnea during sleeping were successfully monitored, indicating that the system appears useful for monitoring the health condition during daily living.

Design and Development of a Run-Time Monitor for Multi-Core Architectures in Cloud Computing

PubMed Central

Kang, Mikyung; Kang, Dong-In; Crago, Stephen P.; Park, Gyung-Leen; Lee, Junghoon

2011-01-01

Cloud computing is a new information technology trend that moves computing and data away from desktops and portable PCs into large data centers. The basic principle of cloud computing is to deliver applications as services over the Internet as well as infrastructure. A cloud is a type of parallel and distributed system consisting of a collection of inter-connected and virtualized computers that are dynamically provisioned and presented as one or more unified computing resources. The large-scale distributed applications on a cloud require adaptive service-based software, which has the capability of monitoring system status changes, analyzing the monitored information, and adapting its service configuration while considering tradeoffs among multiple QoS features simultaneously. In this paper, we design and develop a Run-Time Monitor (RTM) which is a system software to monitor the application behavior at run-time, analyze the collected information, and optimize cloud computing resources for multi-core architectures. RTM monitors application software through library instrumentation as well as underlying hardware through a performance counter optimizing its computing configuration based on the analyzed data. PMID:22163811

Design and development of a run-time monitor for multi-core architectures in cloud computing.

PubMed

Kang, Mikyung; Kang, Dong-In; Crago, Stephen P; Park, Gyung-Leen; Lee, Junghoon

2011-01-01

Cloud computing is a new information technology trend that moves computing and data away from desktops and portable PCs into large data centers. The basic principle of cloud computing is to deliver applications as services over the Internet as well as infrastructure. A cloud is a type of parallel and distributed system consisting of a collection of inter-connected and virtualized computers that are dynamically provisioned and presented as one or more unified computing resources. The large-scale distributed applications on a cloud require adaptive service-based software, which has the capability of monitoring system status changes, analyzing the monitored information, and adapting its service configuration while considering tradeoffs among multiple QoS features simultaneously. In this paper, we design and develop a Run-Time Monitor (RTM) which is a system software to monitor the application behavior at run-time, analyze the collected information, and optimize cloud computing resources for multi-core architectures. RTM monitors application software through library instrumentation as well as underlying hardware through a performance counter optimizing its computing configuration based on the analyzed data.

Smart healthcare textile sensor system for unhindered-pervasive health monitoring

NASA Astrophysics Data System (ADS)

Rai, Pratyush; Kumar, Prashanth S.; Oh, Sechang; Kwon, Hyeokjun; Mathur, Gyanesh N.; Varadan, Vijay K.; Agarwal, M. P.

2012-04-01

Simultaneous monitoring of physiological parameters- multi-lead Electrocardiograph (ECG), Heart rate variability, and blood pressure- is imperative to all forms of medical treatments. Using an array of signal recording devices imply that the patient will have to be confined to a bed. Textiles offer durable platform for embedded sensor and communication systems. The smart healthcare textile, presented here, is a mobile system for remote/wireless data recording and conditioning. The wireless textile system has been designed to monitor a patient in a non-obstructive way. It has a potential for facilitating point of care medicine and streamlining ambulatory medicine. The sensor systems were designed and fabricated with textile based components for easy integration on textile platform. An innovative plethysmographic blood pressure monitoring system was designed and tested as an alternative to inflatable blood pressure sphygmomanometer. Flexible dry electrodes technology was implemented for ECG. The sensor systems were tested and conditioned to daily activities of patients, which is not permissible with halter type systems. The signal quality was assessed for it applicability to medical diagnosis. The results were used to corroborate smart textile sensor system's ability to function as a point of care system that can provide quality healthcare.

Simultaneous excitation system for efficient guided wave structural health monitoring

NASA Astrophysics Data System (ADS)

Hua, Jiadong; Michaels, Jennifer E.; Chen, Xin; Lin, Jing

2017-10-01

Many structural health monitoring systems utilize guided wave transducer arrays for defect detection and localization. Signals are usually acquired using the ;pitch-catch; method whereby each transducer is excited in turn and the response is received by the remaining transducers. When extensive signal averaging is performed, the data acquisition process can be quite time-consuming, especially for metallic components that require a low repetition rate to allow signals to die out. Such a long data acquisition time is particularly problematic if environmental and operational conditions are changing while data are being acquired. To reduce the total data acquisition time, proposed here is a methodology whereby multiple transmitters are simultaneously triggered, and each transmitter is driven with a unique excitation. The simultaneously transmitted waves are captured by one or more receivers, and their responses are processed by dispersion-compensated filtering to extract the response from each individual transmitter. The excitation sequences are constructed by concatenating a series of chirps whose start and stop frequencies are randomly selected from a specified range. The process is optimized using a Monte-Carlo approach to select sequences with impulse-like autocorrelations and relatively flat cross-correlations. The efficacy of the proposed methodology is evaluated by several metrics and is experimentally demonstrated with sparse array imaging of simulated damage.

Application of thoron interference as a tool for simultaneous measurement of radon and thoron with a pulse ionisation chamber.

PubMed

Tripathi, R M; Sumesh, C G; Vinod Kumar, A; Puranik, V D

2013-07-01

Pulse ionisation chamber (PIC)-based monitors measuring radioactive gas radon ((222)Rn) without energy discrimination will have interference due to thoron ((220)Rn) present in the atmosphere. A technique has been developed to use this property of interference for simultaneous measurement of radon and thoron gas. These monitors work on the principle of counting of gross alphas emitted from radon and its progeny. A theoretical model has been developed for the variation of thoron sensitivity with respect to the flow rate of gas through the monitor. The thoron sensitivity of the monitor is found to vary with the flow rate of gas through the monitor. Using this sensitivity, the sampling procedure has been developed and verified for simultaneous measurement of radon and thoron. The PIC-measured radon and thoron concentration using this procedure agrees well with those measured by using standard radon and thoron discriminating monitor.

Simultaneous measurement of refractive index and temperature based on intensity demodulation using matching grating method.

PubMed

Qi, Liang; Zhao, Chun-Liu; Kang, Juan; Jin, Yongxing; Wang, Jianfeng; Ye, Manping; Jin, Shangzhong

2013-07-01

A solution refractive index (SRI) and temperature simultaneous measurement sensor with intensity-demodulation system based on matching grating method were demonstrated. Long period grating written in a photonic crystal fiber (LPG-PCF), provides temperature stable and wavelength dependent optical intensity transmission. The reflective peaks of two fiber Bragg gratings (FBGs), one of which is etched then sensitive to both SRI and temperature, another (FBG2) is only sensitive to temperature, were located in the same linear range of the LPG-PCF's transmission spectrum. An identical FBG with FBG2 was chosen as a matching FBG. When environments (SRI and temperature) change, the wavelength shifts of the FBGs are translated effectively to the reflection intensity changes. By monitoring output lights of unmatching and matching paths, the SRI and temperature were deduced by a signal processing unit. Experimental results show that the simultaneous refractive index and temperature measurement system work well. The proposed sensor system is compact and suitable for in situ applications at lower cost.

Fibre-optic distributed temperature sensing in combined sewer systems.

PubMed

Schilperoort, R P S; Clemens, F H L R

2009-01-01

This paper introduces the application of fibre-optic distributed temperature sensing (DTS) in combined sewer systems. The DTS-technique uses a fibre-optic cable that is inserted into a combined sewer system in combination with a laser instrument that performs measurements and logs the data. The DTS-technique allows monitoring in-sewer temperatures with dense spatial and temporal resolutions. The installation of a fibre-optic cable in a combined sewer system has proven feasible. The use of a single instrument in an easy accessible and safe location that can simultaneously monitor up to several hundreds of monitoring locations makes the DTS set-up easy in use and nearly free of maintenance. Temperature data from a one-week monitoring campaign in an 1,850 m combined sewer system shows the level of detail with which in-sewer processes that affect wastewater temperatures can be studied. Individual discharges from house-connections can be tracked in time and space. With a dedicated cable configuration the confluence of wastewater flows can be observed with a potential to derive the relative contributions of contributary flows to a total flow. Also, the inflow and in-sewer propagation of stormwater can be monitored.

Simultaneous measurement of multiple radiation-induced protein expression profiles using the Luminex(TM) system

NASA Technical Reports Server (NTRS)

Desai, N.; Wu, H.; George, K.; Gonda, S. R.; Cucinotta, F. A.; Cucniotta, F. A. (Principal Investigator)

2004-01-01

Space flight results in the exposure of astronauts to a mixed field of radiation composed of energetic particles of varying energies, and biological indicators of space radiation exposure provides a better understanding of the associated long-term health risks. Current methods of biodosimetry have employed the use of cytogenetic analysis for biodosimetry, and more recently the advent of technological progression has led to advanced research in the use of genomic and proteomic expression profiling to simultaneously assess biomarkers of radiation exposure. We describe here the technical advantages of the Luminex(TM) 100 system relative to traditional methods and its potential as a tool to simultaneously profile multiple proteins induced by ionizing radiation. The development of such a bioassay would provide more relevant post-translational dynamics of stress response and will impart important implications in the advancement of space and other radiation contact monitoring. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.

Electrochemical microsensor system for cancer research on photodynamic therapy in vitro

NASA Astrophysics Data System (ADS)

Marzioch, J.; Kieninger, J.; Sandvik, J. A.; Pettersen, E. O.; Peng, Q.; Urban, G.

2016-10-01

An electrochemical microsensor system to investigate photodynamic therapy of cancer cells in vitro was developed and applied to monitor the cellular respiration during and after photodynamic therapy. The redox activity and therefore influence of the photodynamic drug on the sensor performance was investigated by electrochemical characterization. It was shown, that appropriate operation conditions avoid cross-sensitivity of the sensors to the drug itself. The presented system features a cell culture chamber equipped with microsensors and a laser source to photodynamically treat the cells while simultaneous monitoring of metabolic parameter in situ. Additionally, the optical setup allows to read back fluorescence signals from the photosensitizer itself or other marker molecules parallel to the microsensor readings.

Tevatron beam position monitor upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolbers, Stephen; Banerjee, B.; Barker, B.

2005-05-01

The Tevatron Beam Position Monitor (BPM) readout electronics and software have been upgraded to improve measurement precision, functionality and reliability. The original system, designed and built in the early 1980's, became inadequate for current and future operations of the Tevatron. The upgraded system consists of 960 channels of new electronics to process analog signals from 240 BPMs, new front-end software, new online and controls software, and modified applications to take advantage of the improved measurements and support the new functionality. The new system reads signals from both ends of the existing directional stripline pickups to provide simultaneous proton and antiprotonmore » position measurements. Measurements using the new system are presented that demonstrate its improved resolution and overall performance.« less

Intense Terahertz Fields for Fast Energy Release

DTIC Science & Technology

2016-11-01

could allow us to monitor shock propagation in the sample and observe any effects of THz irradiation . In order to optimize the system, we moved a...the response and access for the THz light needed to simultaneously irradiate the sample. Preliminary measurements of sample responses to each of the

Simultaneous analysis of fourteen endogenous steroid hormones by liquid chromatography tandem mass spectrometry with atmospheric pressure photoionization

EPA Science Inventory

Product Description: To understand how some chemicals affect the endocrine system, controlled lab experiments often monitor how chemicals impact natural steroid hormones in fish. Current methods can target only one or two hormones in a single sample, limiting the information that...

A radar data processing and enhancement system

NASA Technical Reports Server (NTRS)

Anderson, K. F.; Wrin, J. W.; James, R.

1986-01-01

This report describes the space position data processing system of the NASA Western Aeronautical Test Range. The system is installed at the Dryden Flight Research Facility of NASA Ames Research Center. This operational radar data system (RADATS) provides simultaneous data processing for multiple data inputs and tracking and antenna pointing outputs while performing real-time monitoring, control, and data enhancement functions. Experience in support of the space shuttle and aeronautical flight research missions is described, as well as the automated calibration and configuration functions of the system.

Simultaneous Ultrasound Therapy and Monitoring of Microbubble-Seeded Acoustic Cavitation Using a Single-Element Transducer.

PubMed

Heymans, Sophie V; Martindale, Christine F; Suler, Andrej; Pouliopoulos, Antonios N; Dickinson, Robert J; Choi, James J

2017-08-01

Ultrasound-driven microbubble (MB) activity is used in therapeutic applications such as blood clot dissolution and targeted drug delivery. The safety and performance of these technologies are linked to the type and distribution of MB activities produced within the targeted area, but controlling and monitoring these activities in vivo and in real time has proven to be difficult. As therapeutic pulses are often milliseconds long, MB monitoring currently requires a separate transducer used in a passive reception mode. Here, we present a simple, inexpensive, integrated setup, in which a focused single-element transducer can perform ultrasound therapy and monitoring simultaneously. MBs were made to flow through a vessel-mimicking tube, placed within the transducer's focus, and were sonicated with therapeutic pulses (peak rarefactional pressure: 75-827 kPa, pulse lengths: [Formula: see text] and 20 ms). The MB-seeded acoustic emissions were captured using the same transducer. The received signals were separated from the therapeutic signal with a hybrid coupler and a high-pass filter. We discriminated the MB-generated cavitation signal from the primary acoustic field and characterized MB behavior in real time. The simplicity and versatility of our circuit could make existing single-element therapeutic transducers also act as cavitation detectors, allowing the production of compact therapeutic systems with real time monitoring capabilities.

Mobile CARS - IRS Instrument for Simultaneous Spectroscopic Measurement of Multiple Properties in Gaseous Flows

NASA Technical Reports Server (NTRS)

Bivolaru, Daniel; Lee, Joseph W.; Jones, Stephen B.; Tedder, Sarah A.; Danehy, Paul M.; Weikl, M. C.; Magnotti, G.; Cutler, Andrew D.

2007-01-01

This paper describes a measurement system based on the dual-pump coherent anti-Stokes Raman spectroscopy (CARS) and interferometric Rayleigh scattering (IRS) methods. The IRS measurement is performed simultaneously with the CARS measurement using a common green laser beam as a narrow-band light source. The mobile CARS-IRS instrument is designed for the use both in laboratories as well as in ground-based combustion test facilities. Furthermore, it is designed to be easily transported between laboratory and test facility. It performs single-point spatially and temporally resolved simultaneous measurements of temperature, species mole fraction of N2, O2, and H2, and two-components of velocity. A mobile laser system can be placed inside or outside the test facility, while a beam receiving and monitoring system is placed near the measurement location. Measurements in a laboratory small-scale Mach 1.6 H2-air combustion-heated supersonic jet were performed to test the capability of the system. Final setup and pretests of a larger scale reacting jet are ongoing at NASA Langley Research Center s Direct Connect Supersonic Combustor Test Facility (DCSCTF).

Novel application of simultaneous multi-image display during complex robotic abdominal procedures

PubMed Central

2014-01-01

Background The surgical robot offers the potential to integrate multiple views into the surgical console screen, and for the assistant’s monitors to provide real-time views of both fields of operation. This function has the potential to increase patient safety and surgical efficiency during an operation. Herein, we present a novel application of the multi-image display system for simultaneous visualization of endoscopic views during various complex robotic gastrointestinal operations. All operations were performed using the da Vinci Surgical System (Intuitive Surgical, Sunnyvale, CA, USA) with the assistance of Tilepro, multi-input display software, during employment of the intraoperative scopes. Three robotic operations, left hepatectomy with intraoperative common bile duct exploration, low anterior resection, and radical distal subtotal gastrectomy with intracorporeal gastrojejunostomy, were performed by three different surgeons at a tertiary academic medical center. Results The three complex robotic abdominal operations were successfully completed without difficulty or intraoperative complications. The use of the Tilepro to simultaneously visualize the images from the colonoscope, gastroscope, and choledochoscope made it possible to perform additional intraoperative endoscopic procedures without extra monitors or interference with the operations. Conclusion We present a novel use of the multi-input display program on the da Vinci Surgical System to facilitate the performance of intraoperative endoscopies during complex robotic operations. Our study offers another potentially beneficial application of the robotic surgery platform toward integration and simplification of combining additional procedures with complex minimally invasive operations. PMID:24628761

Simultaneous tracking of drug molecules and carriers using aptamer-functionalized fluorescent superstable gold nanorod-carbon nanocapsules during thermo-chemotherapy

NASA Astrophysics Data System (ADS)

Wang, Xue-Wei; Gao, Wei; Fan, Huanhuan; Ding, Ding; Lai, Xiao-Fang; Zou, Yu-Xiu; Chen, Long; Chen, Zhuo; Tan, Weihong

2016-04-01

Controlling and monitoring the drug delivery process is critical to its intended therapeutic function. Many nanocarrier systems for drug delivery have been successfully developed. However, biocompatibility, stability, and simultaneously tracing drugs and nanocarriers present significant limitations. Herein, we have fabricated a multifunctional nanocomposite by coating the gold nanorod (AuNR) with a biocompatible, superstable and fluorescent carbon layer, obtaining the AuNR@carbon core-shell nanocapsule. In this system, the carbon shell, originally obtained in aqueous glucose solutions and, therefore, biocompatible in physiological environments, could be simply loaded with cell-specific aptamers and therapeutic molecules through π-π interactions, a useful tool for cancer-targeted cellular imaging and therapy. Moreover, such a stable and intrinsic fluorescence effect of the AuNR@carbon enabled simultaneous tracking of released therapeutic molecules and nanocarriers under thermo-chemotherapy. The AuNR@carbons had high surface areas and stable shells, as well as unique optical and photothermal properties, making them promising nanostructures for biomedical applications.Controlling and monitoring the drug delivery process is critical to its intended therapeutic function. Many nanocarrier systems for drug delivery have been successfully developed. However, biocompatibility, stability, and simultaneously tracing drugs and nanocarriers present significant limitations. Herein, we have fabricated a multifunctional nanocomposite by coating the gold nanorod (AuNR) with a biocompatible, superstable and fluorescent carbon layer, obtaining the AuNR@carbon core-shell nanocapsule. In this system, the carbon shell, originally obtained in aqueous glucose solutions and, therefore, biocompatible in physiological environments, could be simply loaded with cell-specific aptamers and therapeutic molecules through π-π interactions, a useful tool for cancer-targeted cellular imaging and therapy. Moreover, such a stable and intrinsic fluorescence effect of the AuNR@carbon enabled simultaneous tracking of released therapeutic molecules and nanocarriers under thermo-chemotherapy. The AuNR@carbons had high surface areas and stable shells, as well as unique optical and photothermal properties, making them promising nanostructures for biomedical applications. Electronic supplementary information (ESI) available: Experimental details and characterization data for all new compounds. See DOI: 10.1039/c6nr00369a

A daily living activity remote monitoring system for solitary elderly people.

PubMed

Maki, Hiromichi; Ogawa, Hidekuni; Matsuoka, Shingo; Yonezawa, Yoshiharu; Caldwell, W Morton

2011-01-01

A daily living activity remote monitoring system has been developed for supporting solitary elderly people. The monitoring system consists of a tri-axis accelerometer, six low-power active filters, a low-power 8-bit microcontroller (MC), a 1GB SD memory card (SDMC) and a 2.4 GHz low transmitting power mobile phone (PHS). The tri-axis accelerometer attached to the subject's chest can simultaneously measure dynamic and static acceleration forces produced by heart sound, respiration, posture and behavior. The heart rate, respiration rate, activity, posture and behavior are detected from the dynamic and static acceleration forces. These data are stored in the SD. The MC sends the data to the server computer every hour. The server computer stores the data and makes a graphic chart from the data. When the caregiver calls from his/her mobile phone to the server computer, the server computer sends the graphical chart via the PHS. The caregiver's mobile phone displays the chart to the monitor graphically.

Dynamic fiber Bragg grating strain sensor interrogation with real-time measurement

NASA Astrophysics Data System (ADS)

Park, Jinwoo; Kwon, Yong Seok; Ko, Myeong Ock; Jeon, Min Yong

2017-11-01

We demonstrate a 1550 nm band resonance Fourier-domain mode-locked (FDML) fiber laser with fiber Bragg grating (FBG) array. Using the FDML fiber laser, we successfully demonstrate real-time monitoring of dynamic FBG strain sensor interrogation for structural health monitoring. The resonance FDML fiber laser consists of six multiplexed FBGs, which are arranged in series with delay fiber lengths. It is operated by driving the fiber Fabry-Perot tunable filter (FFP-TF) with a sinusoidal waveform at a frequency corresponding to the round-trip time of the laser cavity. Each FBG forms a laser cavity independently in the FDML fiber laser because the light travels different length for each FBG. The very closely positioned two FBGs in a pair are operated simultaneously with a frequency in the FDML fiber laser. The spatial positions of the sensing pair can be distinguished from the variation of the applied frequency to the FFP-TF. One of the FBGs in the pair is used as a reference signal and the other one is fixed on the piezoelectric transducer stack to apply the dynamic strain. We successfully achieve real-time measurement of the abrupt change of the frequencies applied to the FBG without any signal processing delay. The real-time monitoring system is displayed simultaneously on the monitor for the variation of the two peaks, the modulation interval of the two peaks, and their fast Fourier transform spectrum. The frequency resolution of the dynamic variation could reach up to 0.5 Hz for 2 s integration time. It depends on the integration time to measure the dynamic variation. We believe that the real-time monitoring system will have a potential application for structural health monitoring.

Room air monitor for radioactive aerosols

DOEpatents

Balmer, David K.; Tyree, William H.

1989-04-11

A housing assembly for use with a room air monitor for simultaneous collection and counting of suspended particles includes a casing containing a combination detector-preamplifier system at one end, a filter system at the other end, and an air flow system consisting of an air inlet formed in the casing between the detector-preamplifier system and the filter system and an air passageway extending from the air inlet through the casing and out the end opposite the detector-preamplifier combination. The filter system collects suspended particles transported directly through the housing by means of the air flow system, and these particles are detected and examined for radioactivity by the detector-pre The U.S. Government has rights in this invention pursuant to Contract No. DE-AC04-76DP03533 between the Department of Energy and Rockwell International Corporation.

Implant for in-vivo parameter monitoring, processing and transmitting

DOEpatents

Ericson, Milton N [Knoxville, TN; McKnight, Timothy E [Greenback, TN; Smith, Stephen F [London, TN; Hylton, James O [Clinton, TN

2009-11-24

The present invention relates to a completely implantable intracranial pressure monitor, which can couple to existing fluid shunting systems as well as other internal monitoring probes. The implant sensor produces an analog data signal which is then converted electronically to a digital pulse by generation of a spreading code signal and then transmitted to a location outside the patient by a radio-frequency transmitter to an external receiver. The implanted device can receive power from an internal source as well as an inductive external source. Remote control of the implant is also provided by a control receiver which passes commands from an external source to the implant system logic. Alarm parameters can be programmed into the device which are capable of producing an audible or visual alarm signal. The utility of the monitor can be greatly expanded by using multiple pressure sensors simultaneously or by combining sensors of various physiological types.

Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring

DOEpatents

Ericson, Milton N.; McKnight, Timothy E.; Smith, Stephen F.; Hylton, James O.

2003-01-01

The present invention relates to a completely implantable intracranial pressure monitor, which can couple to existing fluid shunting systems as well as other internal monitoring probes. The implant sensor produces an analog data signal which is then converted electronically to a digital pulse by generation of a spreading code signal and then transmitted to a location outside the patient by a radio-frequency transmitter to an external receiver. The implanted device can receive power from an internal source as well as an inductive external source. Remote control of the implant is also provided by a control receiver which passes commands from an external source to the implant system logic. Alarm parameters can be programmed into the device which are capable of producing an audible or visual alarm signal. The utility of the monitor can be greatly expanded by using multiple pressure sensors simultaneously or by combining sensors of various physiological types.

A WSN-based tool for urban and industrial fire-fighting.

PubMed

De San Bernabe Clemente, Alberto; Martínez-de Dios, José Ramiro; Ollero Baturone, Aníbal

2012-11-06

This paper describes a WSN tool to increase safety in urban and industrial fire-fighting activities. Unlike most approaches, we assume that there is no preexisting WSN in the building, which involves interesting advantages but imposes some constraints. The system integrates the following functionalities: fire monitoring, firefighter monitoring and dynamic escape path guiding. It also includes a robust localization method that employs RSSI-range models dynamically trained to cope with the peculiarities of the environment. The training and application stages of the method are applied simultaneously, resulting in significant adaptability. Besides simulations and laboratory tests, a prototype of the proposed system has been validated in close-to-operational conditions.

Method and apparatus for the simultaneous display and correlation of independently generated images

DOEpatents

Vaitekunas, Jeffrey J.; Roberts, Ronald A.

1991-01-01

An apparatus and method for location by location correlation of multiple images from Non-Destructive Evaluation (NDE) and other sources. Multiple images of a material specimen are displayed on one or more monitors of an interactive graphics system. Specimen landmarks are located in each image and mapping functions from a reference image to each other image are calcuated using the landmark locations. A location selected by positioning a cursor in the reference image is mapped to the other images and location identifiers are simultaneously displayed in those images. Movement of the cursor in the reference image causes simultaneous movement of the location identifiers in the other images to positions corresponding to the location of the reference image cursor.

Ambulatory diffuse optical tomography and multimodality physiological monitoring system for muscle and exercise applications

NASA Astrophysics Data System (ADS)

Hu, Gang; Zhang, Quan; Ivkovic, Vladimir; Strangman, Gary E.

2016-09-01

Ambulatory diffuse optical tomography (aDOT) is based on near-infrared spectroscopy (NIRS) and enables three-dimensional imaging of regional hemodynamics and oxygen consumption during a person's normal activities. Although NIRS has been previously used for muscle assessment, it has been notably limited in terms of the number of channels measured, the extent to which subjects can be ambulatory, and/or the ability to simultaneously acquire synchronized auxiliary data such as electromyography (EMG) or electrocardiography (ECG). We describe the development of a prototype aDOT system, called NINscan-M, capable of ambulatory tomographic imaging as well as simultaneous auxiliary multimodal physiological monitoring. Powered by four AA size batteries and weighing 577 g, the NINscan-M prototype can synchronously record 64-channel NIRS imaging data, eight channels of EMG, ECG, or other analog signals, plus force, acceleration, rotation, and temperature for 24+ h at up to 250 Hz. We describe the system's design, characterization, and performance characteristics. We also describe examples of isometric, cycle ergometer, and free-running ambulatory exercise to demonstrate tomographic imaging at 25 Hz. NINscan-M represents a multiuse tool for muscle physiology studies as well as clinical muscle assessment.

Modeling of flow systems for implementation under KATE

NASA Technical Reports Server (NTRS)

Whitlow, Jonathan E.

1990-01-01

The modeling of flow systems is a task currently being investigated at Kennedy Space Center in parallel with the development of the KATE artificial intelligence system used for monitoring diagnosis and control. Various aspects of the modeling issues are focussed on with particular emphasis on a water system scheduled for demonstration within the KATE environment in September of this year. LISP procedures were written to solve the continuity equations for three internal pressure nodes using Newton's method for simultaneous nonlinear equations.

Ecohydrological drought monitoring and prediction using a land data assimilation system

NASA Astrophysics Data System (ADS)

Sawada, Y.; Koike, T.

2017-12-01

Despite the importance of the ecological and agricultural aspects of severe droughts, few drought monitor and prediction systems can forecast the deficit of vegetation growth. To address this issue, we have developed a land data assimilation system (LDAS) which can simultaneously simulate soil moisture and vegetation dynamics. By assimilating satellite-observed passive microwave brightness temperature, which is sensitive to both surface soil moisture and vegetation water content, we can significantly improve the skill of a land surface model to simulate surface soil moisture, root zone soil moisture, and leaf area index (LAI). We run this LDAS to generate a global ecohydrological land surface reanalysis product. In this presentation, we will demonstrate how useful this new reanalysis product is to monitor and analyze the historical mega-droughts. In addition, using the analyses of soil moistures and LAI as initial conditions, we can forecast the ecological and hydrological conditions in the middle of droughts. We will present our recent effort to develop a near real time ecohydrological drought monitoring and prediction system in Africa by combining the LDAS and the atmospheric seasonal prediction.

A novel Multi-Fiber Optode sensor system (MuFO) for monitoring oxygen

NASA Astrophysics Data System (ADS)

Koop-Jakobsen, K.; Fischer, J.; Wenzhöfer, F.

2012-04-01

In the marine environment, dissolved oxygen concentrations often vary significantly spatially as well as temporally. Monitoring these variations is essential for our understanding of the biological and chemical processes controlling the oxygen dynamics in water columns and sediments. Such investigations require a high number of measuring points and a high temporal resolution. A Multi-Fiber Optode sensor system (MuFO) was designed to assess these requirements. The MuFO system simultaneously controls 100 fiber optodes enabling continuous monitoring of oxygen in 100 positions within a 5-10m radius. The measurements are based on quenching of an oxygen sensitive luminophore, which is immobilised at the end of each fiber optode. The optical oxygen measurements are based on lifetime-imaging, which are converted into oxygen concentrations using a multipoint calibration. At a constant temperature of 21C, the system overall had a mean accuracy of 1.3%, a precision of 0.2% air saturation, the average 90% response time was 16 seconds and the detection limit was 0.1% air saturation. The MuFO set-up was build into a waterproof titanium casing for marine field applications. The system is battery-powered and has a maximum operational capacity of 15 hours for continuous measurements. The MuFO system was recently used for various research tasks in the marine environment: Mounted on a lander, the in situ MuFO system was used for investigations of oxygen dynamics in marine water columns placing the fiber optodes in a vertical line on a 7m high pole. For studies of oxygen dynamics in marine wetland rhizospheres, the sensing ends of the fiber optodes were covered with a 50cm protective sleeve made from stainless steel tubing, and the sensors were manually pushed into the rhizosphere. For laboratory measurements of sediment oxygen demand, the MuFO system was used to simultaneously monitor the oxygen consumption in multiple sediment slurry incubations. The MuFO system proved to be a useful tool for field studies as well as in the laboratory and the system has multiple applications in marine research. This work was supported by the 7th framework EU-projects SENSEnet and HYPOX.

Simultaneous sequential monitoring of efficacy and safety led to masking of effects.

PubMed

van Eekelen, Rik; de Hoop, Esther; van der Tweel, Ingeborg

2016-08-01

Usually, sequential designs for clinical trials are applied on the primary (=efficacy) outcome. In practice, other outcomes (e.g., safety) will also be monitored and influence the decision whether to stop a trial early. Implications of simultaneous monitoring on trial decision making are yet unclear. This study examines what happens to the type I error, power, and required sample sizes when one efficacy outcome and one correlated safety outcome are monitored simultaneously using sequential designs. We conducted a simulation study in the framework of a two-arm parallel clinical trial. Interim analyses on two outcomes were performed independently and simultaneously on the same data sets using four sequential monitoring designs, including O'Brien-Fleming and Triangular Test boundaries. Simulations differed in values for correlations and true effect sizes. When an effect was present in both outcomes, competition was introduced, which decreased power (e.g., from 80% to 60%). Futility boundaries for the efficacy outcome reduced overall type I errors as well as power for the safety outcome. Monitoring two correlated outcomes, given that both are essential for early trial termination, leads to masking of true effects. Careful consideration of scenarios must be taken into account when designing sequential trials. Simulation results can help guide trial design. Copyright © 2016 Elsevier Inc. All rights reserved.

Simultaneous Measurement of Fluorescence, Conversion and Physical/mechanical Properties for Monitoring Bulk and Localized Photopolymerization Reactions in Heterogeneous Systems

PubMed Central

Medel, S.; Bosch, P.; Grabchev, I.; Shah, P. K.; Liu, J.; Aguirre-Soto, A.; Stansbury, J. W.

2016-01-01

An FT-NIR spectrometer, rheometer and fluorescence spectrophotometer were coupled for the real-time monitoring of polymerization reactions, allowing the simultaneous tracking of polymerization kinetics, storage modulus as well as fluorescence. In this study, a methacrylate functionalized dansyl chromophore (DANSMA) was synthesized and two different nanogels were made from urethane dimethacrylate and isobornyl methacrylate. Two series of resin formulations were prepared using the DANSMA probe, ethoxylated bisphenol A dimethacrylate as the matrix monomer, Irgacure® 651 as the initiator and the dispersed, monomer-swollen nanogels to give clear UV-curable resins. Placement of the fluorescent probe either throughout the resin or linked into the nanogel before its dispersion in the matrix provides a tool to study how the nanogel structure affects local network development by means of fluorescence from the DANSMA probe. We demonstrate the potential of this new technique using a composite as the two phase system (resin and polymerizable nanogel) including a dansyl derivative as a polymerizable probe to follow the reactions that are taking places in both phases. PMID:27213038

Force-Balance Dynamic Display

NASA Technical Reports Server (NTRS)

Ferris, Alice T.; White, William C.

1988-01-01

Balance dynamic display unit (BDDU) is compact system conditioning six dynamic analog signals so they are monitored simultaneously in real time on single-trace oscilloscope. Typical BDDU oscilloscope display in scan mode shows each channel occupying one-sixth of total trace. System features two display modes usable with conventional, single-channel oscilloscope: multiplexed six-channel "bar-graph" format and single-channel display. Two-stage visual and audible limit alarm provided for each channel.

Integration of silicon-based neural probes and micro-drive arrays for chronic recording of large populations of neurons in behaving animals

NASA Astrophysics Data System (ADS)

Michon, Frédéric; Aarts, Arno; Holzhammer, Tobias; Ruther, Patrick; Borghs, Gustaaf; McNaughton, Bruce; Kloosterman, Fabian

2016-08-01

Objective. Understanding how neuronal assemblies underlie cognitive function is a fundamental question in system neuroscience. It poses the technical challenge to monitor the activity of populations of neurons, potentially widely separated, in relation to behaviour. In this paper, we present a new system which aims at simultaneously recording from a large population of neurons from multiple separated brain regions in freely behaving animals. Approach. The concept of the new device is to combine the benefits of two existing electrophysiological techniques, i.e. the flexibility and modularity of micro-drive arrays and the high sampling ability of electrode-dense silicon probes. Main results. Newly engineered long bendable silicon probes were integrated into a micro-drive array. The resulting device can carry up to 16 independently movable silicon probes, each carrying 16 recording sites. Populations of neurons were recorded simultaneously in multiple cortical and/or hippocampal sites in two freely behaving implanted rats. Significance. Current approaches to monitor neuronal activity either allow to flexibly record from multiple widely separated brain regions (micro-drive arrays) but with a limited sampling density or to provide denser sampling at the expense of a flexible placement in multiple brain regions (neural probes). By combining these two approaches and their benefits, we present an alternative solution for flexible and simultaneous recordings from widely distributed populations of neurons in freely behaving rats.

Multichannel wearable system dedicated for simultaneous electroencephalography/near-infrared spectroscopy real-time data acquisitions

NASA Astrophysics Data System (ADS)

Lareau, Etienne; Lesage, Frederic; Pouliot, Philippe; Nguyen, Dang; Le Lan, Jerome; Sawan, Mohamad

2011-09-01

Functional neuroimaging is becoming a valuable tool in cognitive research and clinical applications. The clinical context brings specific constraints that include the requirement of a high channel count to cover the whole head, high sensitivity for single event detection, and portability for long-term bedside monitoring. For epilepsy and stroke monitoring, the combination of electroencephalography (EEG) and functional near-infrared spectroscopy (NIRS) is expected to provide useful clinical information, and efforts have been deployed to create prototypes able to simultaneously acquire both measurement modalities. However, to the best of our knowledge, existing systems lack portability, NIRS sensitivity, or have low channel count. We present a battery-powered, portable system with potentially up to 32 EEG channels, 32 NIRS light sources, and 32 detectors. Avalanche photodiodes allow for high NIRS sensitivity and the autonomy of the system is over 24 h. A reduced channel count prototype with 8 EEG channels, 8 sources, and 8 detectors was tested on phantoms. Further validation was done on five healthy adults using a visual stimulation protocol to detect local hemodynamic changes and visually evoked potentials. Results show good concordance with literature regarding functional activations and suggest sufficient performance for clinical use, provided some minor adjustments were made.

Simultaneous monitoring of insulin and islet amyloid polypeptide secretion from islets of Langerhans on a microfluidic device.

PubMed

Lomasney, Anna R; Yi, Lian; Roper, Michael G

2013-08-20

A method was developed that allowed simultaneous monitoring of the acute secretory dynamics of insulin and islet amyloid polypeptide (IAPP) from islets of Langerhans using a microfluidic system with two-color detection. A flow-switching feature enabled changes in the perfusion media within 5 s, allowing rapid exchange of the glucose concentrations delivered to groups of islets. The perfusate was continuously sampled by electroosmotic flow and mixed online with Cy5-labeled insulin, fluorescein isothiocyanate (FITC)-labeled IAPP, anti-insulin, and anti-IAPP antibodies in an 8.15 cm mixing channel maintained at 37 °C. The immunoassay mixture was injected for 0.3 s onto a 1.5 cm separation channel at 11.75 s intervals and immunoassay reagents detected using 488 and 635 nm lasers with two independent photomultiplier tubes for detection of the FITC and Cy5 signal. RSD of the bound-to-free immunoassay ratios ranged from 2 to 7% with LODs of 20 nM for insulin and 1 nM for IAPP. Simultaneous secretion profiles of the two peptides were monitored from groups of 4-10 islets during multiple step changes in glucose concentration. Insulin and IAPP were secreted in an approximately 10:1 ratio and displayed similar responses to step changes from 3 to 11 or 20 mM glucose. The ability to monitor the secretory dynamics of multiple peptides from islets of Langerhans in a highly automated fashion is expected to be a useful tool for investigating hormonal regulation of glucose homeostasis.

Nonintrusive biosignal measurement system in a vehicle.

PubMed

Lee, Haet Bit; Choi, Jong Min; Kim, Jung Soo; Kim, Yun Seong; Baek, Hyun Jae; Ryu, Myung Suk; Sohn, Ryang Hee; Park, Kwang Suk

2007-01-01

Measurement of driver's state is important in both daily healthcare and prevention of car accidents. Existing measurement methods, however, are too complex and uncomfortable to measure for everyday. A nonintrusive biosignal monitoring system is demanded for increasing the accessibility. In this paper, we proposed a nonintrusive measurement system integrated in a vehicle for recording electrocardiographic (ECG) signals and tested the performance of the system. The system consists of dry electrodes attached to the steering wheel and a wireless communication module using a Bluetooth device. ECG signals measured by our system were compared with those by a conventional system employing wet electrodes during real city road driving. Various parameters used for HRV analysis in time and frequency domain showed no significant differences between the two simultaneously measured ECG signals. The result implies the possibility that developed system could have a potential to monitor health information in a vehicle instead of commercial equipments.

Stretchable inorganic nanomembrane electronics for healthcare devices

NASA Astrophysics Data System (ADS)

Kim, Dae-Hyeong; Son, Donghee; Kim, Jaemin

2015-05-01

Flexible or stretchable electronic devices for healthcare technologies have attracted much attention in terms of usefulness to assist doctors in their operating rooms and to monitor patients' physical conditions for a long period of time. Each device to monitor the patients' physiological signals real-time, such as strain, pressure, temperature, and humidity, etc. has been reported recently. However, their limitations are found in acquisition of various physiological signals simultaneously because all the functions are not assembled in one skin-like electronic system. Here, we describe a skin-like, multi-functional healthcare system, which includes single crystalline silicon nanomembrane based sensors, nanoparticle-integrated non-volatile memory modules, electro-resistive thermal actuators, and drug delivery. Smart prosthetics coupled with therapeutic electronic system would provide new approaches to personalized healthcare.

Ultrasonic ranging and data telemetry system

DOEpatents

Brashear, Hugh R.; Blair, Michael S.; Phelps, James E.; Bauer, Martin L.; Nowlin, Charles H.

1990-01-01

An ultrasonic ranging and data telemetry system determines a surveyor's position and automatically links it with other simultaneously taken survey data. An ultrasonic and radio frequency (rf) transmitter are carried by the surveyor in a backpack. The surveyor's position is determined by calculations that use the measured transmission times of an airborne ultrasonic pulse transmitted from the backpack to two or more prepositioned ultrasonic transceivers. Once a second, rf communications are used both to synchronize the ultrasonic pulse transmission-time measurements and to transmit other simultaneously taken survey data. The rf communications are interpreted by a portable receiver and microcomputer which are brought to the property site. A video display attached to the computer provides real-time visual monitoring of the survey progress and site coverage.

DiAs Web Monitoring: A Real-Time Remote Monitoring System Designed for Artificial Pancreas Outpatient Trials

PubMed Central

Place, Jérôme; Robert, Antoine; Brahim, Najib Ben; Patrick, Keith-Hynes; Farret, Anne; Marie-Josée, Pelletier; Buckingham, Bruce; Breton, Marc; Kovatchev, Boris; Renard, Eric

2013-01-01

Background Developments in an artificial pancreas (AP) for patients with type 1 diabetes have allowed a move toward performing outpatient clinical trials. “Home-like” environment implies specific protocol and system adaptations among which the introduction of remote monitoring is meaningful. We present a novel tool allowing multiple patients to monitor AP use in home-like settings. Methods We investigated existing systems, performed interviews of experienced clinical teams, listed required features, and drew several mockups of the user interface. The resulting application was tested on the bench before it was used in three outpatient studies representing 3480 h of remote monitoring. Results Our tool, called DiAs Web Monitoring (DWM), is a web-based application that ensures reception, storage, and display of data sent by AP systems. Continuous glucose monitoring (CGM) and insulin delivery data are presented in a colored chart to facilitate reading and interpretation. Several subjects can be monitored simultaneously on the same screen, and alerts are triggered to help detect events such as hypoglycemia or CGM failures. In the third trial, DWM received approximately 460 data per subject per hour: 77% for log messages, 5% for CGM data. More than 97% of transmissions were achieved in less than 5 min. Conclusions Transition from a hospital setting to home-like conditions requires specific AP supervision to which remote monitoring systems can contribute valuably. DiAs Web Monitoring worked properly when tested in our outpatient studies. It could facilitate subject monitoring and even accelerate medical and technical assessment of the AP. It should now be adapted for long-term studies with an enhanced notification feature. J Diabetes Sci Technol 2013;7(6):1427–1435 PMID:24351169

DiAs web monitoring: a real-time remote monitoring system designed for artificial pancreas outpatient trials.

PubMed

Place, Jérôme; Robert, Antoine; Ben Brahim, Najib; Keith-Hynes, Patrick; Farret, Anne; Pelletier, Marie-Josée; Buckingham, Bruce; Breton, Marc; Kovatchev, Boris; Renard, Eric

2013-11-01

Developments in an artificial pancreas (AP) for patients with type 1 diabetes have allowed a move toward performing outpatient clinical trials. "Home-like" environment implies specific protocol and system adaptations among which the introduction of remote monitoring is meaningful. We present a novel tool allowing multiple patients to monitor AP use in home-like settings. We investigated existing systems, performed interviews of experienced clinical teams, listed required features, and drew several mockups of the user interface. The resulting application was tested on the bench before it was used in three outpatient studies representing 3480 h of remote monitoring. Our tool, called DiAs Web Monitoring (DWM), is a web-based application that ensures reception, storage, and display of data sent by AP systems. Continuous glucose monitoring (CGM) and insulin delivery data are presented in a colored chart to facilitate reading and interpretation. Several subjects can be monitored simultaneously on the same screen, and alerts are triggered to help detect events such as hypoglycemia or CGM failures. In the third trial, DWM received approximately 460 data per subject per hour: 77% for log messages, 5% for CGM data. More than 97% of transmissions were achieved in less than 5 min. Transition from a hospital setting to home-like conditions requires specific AP supervision to which remote monitoring systems can contribute valuably. DiAs Web Monitoring worked properly when tested in our outpatient studies. It could facilitate subject monitoring and even accelerate medical and technical assessment of the AP. It should now be adapted for long-term studies with an enhanced notification feature. © 2013 Diabetes Technology Society.

Utilizing the Cyberforest live sound system with social media to remotely conduct woodland bird censuses in Central Japan.

PubMed

Saito, Kaoru; Nakamura, Kazuhiko; Ueta, Mutsuyuki; Kurosawa, Reiko; Fujiwara, Akio; Kobayashi, Hill Hiroki; Nakayama, Masaya; Toko, Ayako; Nagahama, Kazuyo

2015-11-01

We have developed a system that streams and archives live sound from remote areas across Japan via an unmanned automatic camera. The system was used to carry out pilot bird censuses in woodland; this allowed us to examine the use of live sound transmission and the role of social media as a mediator in remote scientific monitoring. The system has been streaming sounds 8 h per day for more than five years. We demonstrated that: (1) the transmission of live sound from a remote woodland could be used effectively to monitor birds in a remote location; (2) the simultaneous involvement of several participants via Internet Relay Chat to listen to live sound transmissions could enhance the accuracy of census data collection; and (3) interactions through Twitter allowed members of the public to engage or help with the remote monitoring of birds and experience inaccessible nature through the use of novel technologies.

Remote online monitoring and measuring system for civil engineering structures

NASA Astrophysics Data System (ADS)

Kujawińska, Malgorzata; Sitnik, Robert; Dymny, Grzegorz; Karaszewski, Maciej; Michoński, Kuba; Krzesłowski, Jakub; Mularczyk, Krzysztof; Bolewicki, Paweł

2009-06-01

In this paper a distributed intelligent system for civil engineering structures on-line measurement, remote monitoring, and data archiving is presented. The system consists of a set of optical, full-field displacement sensors connected to a controlling server. The server conducts measurements according to a list of scheduled tasks and stores the primary data or initial results in a remote centralized database. Simultaneously the server performs checks, ordered by the operator, which may in turn result with an alert or a specific action. The structure of whole system is analyzed along with the discussion on possible fields of application and the ways to provide a relevant security during data transport. Finally, a working implementation consisting of a fringe projection, geometrical moiré, digital image correlation and grating interferometry sensors and Oracle XE database is presented. The results from database utilized for on-line monitoring of a threshold value of strain for an exemplary area of interest at the engineering structure are presented and discussed.

Remote monitoring and security alert based on motion detection using mobile

NASA Astrophysics Data System (ADS)

Suganya Devi, K.; Srinivasan, P.

2016-03-01

Background model does not have any robust solution and constitutes one of the main problems in surveillance systems. The aim of the paper is to provide a mobile based security to a remote monitoring system through a WAP using GSM modem. It is most designed to provide durability and versatility for a wide variety of indoor and outdoor applications. It is compatible with both narrow and band networks and provides simultaneous image detection. The communicator provides remote control, event driven recording, including pre-alarm and post-alarm and image motion detection. The web cam allowing them to be mounted either to a ceiling or wall without requiring bracket, with the use of web cam. We could continuously monitoring status in the client system through the web. If any intruder arrives in the client system, server will provide an alert to the mobile (what we are set in the message that message send to the authorized person) and the client can view the image using WAP.

Tracking Three-Dimensional Fish Behavior with a New Marine Acoustic Telemetry System

NASA Technical Reports Server (NTRS)

Brosnan, Ian G.; McGarry, Louise P.; Greene, Charles H.; Steig, Tracey W.; Johnston, Samuel V.; Ehrenberg, John E.

2015-01-01

The persistent monitoring capability provided by acoustic telemetry systems allows us to study behavior, movement, and resource selection of mobile marine animals. Current marine acoustic telemetry systems are challenged by localization errors and limits in the number of animals that can be tracked simultaneously. We designed a new system to provide detection ranges of up to 1 km, to reduce localization errors to less than 1 m, and to increase to 500 the number of unique tags simultaneously tracked. The design builds on HTIs experience of more than a decade developing acoustic telemetry systems for freshwater environments. A field trial of the prototype system was conducted at the University of Washingtons Friday Harbor Marine Laboratory (Friday Harbor, WA). Copper rockfish (Sebastes caurinus) were selected for field trials of this new system because their high site-fidelity and small home ranges provide ample opportunity to track individual fish behavior while testing our ability to characterize the movements of a species of interest to management authorities.

Better Physician's 'Black Bags'

NASA Technical Reports Server (NTRS)

1976-01-01

The "black bag" is outgrowth of astronaut monitoring technology from NASA's Johnson Space Center. Technically known as the portable medical status system, a highly advanced physician's "black bag" weighs less than 30 pounds, yet contains equipment for monitoring and recording vital signs, electrocardiograms, and electroencephalograms. Liquid crystal displays are used to present 15 digits of data simultaneously for long periods of time without excessive use of battery power. Single printed circuit card contains all circuitry required to measure and display vital signs such as heart and respiration rate, temperature, and blood pressure.

No moving parts safe & arm apparatus and method with monitoring and built-in-test for optical firing of explosive systems

DOEpatents

Hendrix, J.L.

1995-04-11

A laser initiated ordnance controller apparatus which provides a safe and arm scheme with no moving parts. The safe & arm apparatus provides isolation of firing energy to explosive devices using a combination of polarization isolation and control through acousto-optical deviation of laser energy pulses. The apparatus provides constant monitoring of the systems status and performs 100% built-in-test at any time prior to ordnance ignition without the risk of premature ignition or detonation. The apparatus has a computer controller, a solid state laser, an acousto-optic deflector and RF drive circuitry, built-in-test optics and electronics, and system monitoring capabilities. The optical system is completed from the laser beam power source to the pyrotechnic ordnance through fiber optic cabling, optical splitters and optical connectors. During operation of the apparatus, a command is provided by the computer controller and, simultaneous with laser flashlamp fire, the safe & arm device is opened for approximately 200 microseconds which allows the laser pulse to transmit through the device. The arm signal also energizes the laser power supply and activates the acousto-optical deflector. When the correct fire format command is received, the acousto-optic deflector moves to the selected event channel, and the channel is verified to ensure the system is pointing to the correct position. Laser energy is transmitted through the fiber where an ignitor or detonator designed to be sensitive to optical pulses is fired at the end of the fiber channel. Simultaneous event channels may also be utilized by optically splitting a single event channel. The built-in-test may be performed anytime prior to ordnance ignition. 6 figures.

No moving parts safe & arm apparatus and method with monitoring and built-in-test for optical firing of explosive systems

DOEpatents

Hendrix, James L.

1995-01-01

A laser initiated ordnance controller apparatus which provides a safe and m scheme with no moving parts. The safe & arm apparatus provides isolation of firing energy to explosive devices using a combination of polarization isolation and control through acousto-optical deviation of laser energy pulses. The apparatus provides constant monitoring of the systems status and performs 100% built-in-test at any time prior to ordnance ignition without the risk of premature ignition or detonation. The apparatus has a computer controller, a solid state laser, an acousto-optic deflector and RF drive circuitry, built-in-test optics and electronics, and system monitoring capabilities. The optical system is completed from the laser beam power source to the pyrotechnic ordnance through fiber optic cabling, optical splitters and optical connectors. During operation of the apparatus, a command is provided by the computer controller and, simultaneous with laser flashlamp fire, the safe & arm device is opened for approximately 200 microseconds which allows the laser pulse to transmit through the device. The arm signal also energizes the laser power supply and activates the acousto-optical deflector. When the correct fire format command is received, the acousto-optic deflector moves to the selected event channel, and the channel is verified to ensure the system is pointing to the correct position. Laser energy is transmitted through the fiber where an ignitor or detonator designed to be sensitive to optical pulses is fired at the end of the fiber channel. Simultaneous event channels may also be utilized by optically splitting a single event channel. The built-in-test may be performed anytime prior to ordnance ignition.

The Seasat SAR Wind and Ocean Wave Monitoring Capabilities: A case study for pass 1339m

NASA Technical Reports Server (NTRS)

Beal, R. C.

1980-01-01

A well organized low energy 11 sec. swell system off the East Coast of the U.S. was detected with the Seasat Synthetic Aperture Radar and successfully tracked from deep water, across the continental shelf, and into shallow water. In addition, a less organized 7 sec. system was tentatively identified in the imagery. Both systems were independently confirmed with simultaneous wave spectral measurements from a research pier, aircraft laser profilometer data, and Fleet Numerical Spectral Ocean Wave Models.

Eyeglasses based wireless electrolyte and metabolite sensor platform.

PubMed

Sempionatto, Juliane R; Nakagawa, Tatsuo; Pavinatto, Adriana; Mensah, Samantha T; Imani, Somayeh; Mercier, Patrick; Wang, Joseph

2017-05-16

The demand for wearable sensors has grown rapidly in recent years, with increasing attention being given to epidermal chemical sensing. Here, we present the first example of a fully integrated eyeglasses wireless multiplexed chemical sensing platform capable of real-time monitoring of sweat electrolytes and metabolites. The new concept has been realized by integrating an amperometric lactate biosensor and a potentiometric potassium ion-selective electrode into the two nose-bridge pads of the glasses and interfacing them with a wireless electronic backbone placed on the glasses' arms. Simultaneous real-time monitoring of sweat lactate and potassium levels with no apparent cross-talk is demonstrated along with wireless signal transduction. The electrochemical sensors were screen-printed on polyethylene terephthalate (PET) stickers and placed on each side of the glasses' nose pads in order to monitor sweat metabolites and electrolytes. The electronic backbone on the arms of the glasses' frame offers control of the amperometric and potentiometric transducers and enables Bluetooth wireless data transmission to the host device. The new eyeglasses system offers an interchangeable-sensor feature in connection with a variety of different nose-bridge amperometric and potentiometric sensor stickers. For example, the lactate bridge-pad sensor was replaced with a glucose one to offer convenient monitoring of sweat glucose. Such a fully integrated wireless "Lab-on-a-Glass" multiplexed biosensor platform can be readily expanded for the simultaneous monitoring of additional sweat electrolytes and metabolites.

A WSN-Based Tool for Urban and Industrial Fire-Fighting

PubMed Central

De San Bernabe Clemente, Alberto; Dios, José Ramiro Martínez-de; Baturone, Aníbal Ollero

2012-01-01

This paper describes a WSN tool to increase safety in urban and industrial fire-fighting activities. Unlike most approaches, we assume that there is no preexisting WSN in the building, which involves interesting advantages but imposes some constraints. The system integrates the following functionalities: fire monitoring, firefighter monitoring and dynamic escape path guiding. It also includes a robust localization method that employs RSSI-range models dynamically trained to cope with the peculiarities of the environment. The training and application stages of the method are applied simultaneously, resulting in significant adaptability. Besides simulations and laboratory tests, a prototype of the proposed system has been validated in close-to-operational conditions. PMID:23202198

Tracking the NOvA Detectors' Performance

NASA Astrophysics Data System (ADS)

Psihas, Fernanda; NOvA Collaboration

2016-03-01

The NOvA experiment measures long baseline νμ -->νe oscillations in Fermilab's NuMI beam. We employ two detectors equipped with over 10 thousand sets of data-taking electronics; avalanche photo diodes and front end boards which collect and process the scintillation signal from particle interactions within the detectors. These sets of electronics -as well as the systems which power and cool them- must be monitored and maintained at precise working conditions to ensure maximal data-taking uptime, good data quality and a lasting life for our detectors. This poster describes the automated systems used on NOvA to simultaneously monitor our data quality, diagnose hardware issues, track our performance and coordinate maintenance for the detectors.

A Review of Hybrid Fiber-Optic Distributed Simultaneous Vibration and Temperature Sensing Technology and Its Geophysical Applications

PubMed Central

2017-01-01

Distributed sensing systems can transform an optical fiber cable into an array of sensors, allowing users to detect and monitor multiple physical parameters such as temperature, vibration and strain with fine spatial and temporal resolution over a long distance. Fiber-optic distributed acoustic sensing (DAS) and distributed temperature sensing (DTS) systems have been developed for various applications with varied spatial resolution, and spectral and sensing range. Rayleigh scattering-based phase optical time domain reflectometry (OTDR) for vibration and Raman/Brillouin scattering-based OTDR for temperature and strain measurements have been developed over the past two decades. The key challenge has been to find a methodology that would enable the physical parameters to be determined at any point along the sensing fiber with high sensitivity and spatial resolution, yet within acceptable frequency range for dynamic vibration, and temperature detection. There are many applications, especially in geophysical and mining engineering where simultaneous measurements of vibration and temperature are essential. In this article, recent developments of different hybrid systems for simultaneous vibration, temperature and strain measurements are analyzed based on their operation principles and performance. Then, challenges and limitations of the systems are highlighted for geophysical applications. PMID:29104259

A biofilm microreactor system for simultaneous electrochemical and nuclear magnetic resonance techniques.

PubMed

Renslow, R S; Babauta, J T; Majors, P D; Mehta, H S; Ewing, R J; Ewing, T W; Mueller, K T; Beyenal, H

2014-01-01

Nuclear magnetic resonance (NMR) techniques are ideally suited for the study of biofilms and for probing their microenvironments because these techniques allow for noninvasive interrogation and in situ monitoring with high resolution. By combining NMR with simultaneous electrochemical techniques, it is possible to sustain and study live biofilms respiring on electrodes. Here, we describe a biofilm microreactor system, including a reusable and a disposable reactor, that allows for simultaneous electrochemical and NMR techniques (EC-NMR) at the microscale. Microreactors were designed with custom radio frequency resonator coils, which allowed for NMR measurements of biofilms growing on polarized gold electrodes. For an example application of this system we grew Geobacter sulfurreducens biofilms on electrodes. EC-NMR was used to investigate growth medium flow velocities and depth-resolved acetate concentration inside the biofilm. As a novel contribution we used Monte Carlo error analysis to estimate the standard deviations of the acetate concentration measurements. Overall, we found that the disposable EC-NMR microreactor provided a 9.7 times better signal-to-noise ratio over the reusable reactor. The EC-NMR biofilm microreactor system can ultimately be used to correlate extracellular electron transfer rates with metabolic reactions and explore extracellular electron transfer mechanisms.

A Review of Hybrid Fiber-Optic Distributed Simultaneous Vibration and Temperature Sensing Technology and Its Geophysical Applications.

PubMed

Miah, Khalid; Potter, David K

2017-11-01

Distributed sensing systems can transform an optical fiber cable into an array of sensors, allowing users to detect and monitor multiple physical parameters such as temperature, vibration and strain with fine spatial and temporal resolution over a long distance. Fiber-optic distributed acoustic sensing (DAS) and distributed temperature sensing (DTS) systems have been developed for various applications with varied spatial resolution, and spectral and sensing range. Rayleigh scattering-based phase optical time domain reflectometry (OTDR) for vibration and Raman/Brillouin scattering-based OTDR for temperature and strain measurements have been developed over the past two decades. The key challenge has been to find a methodology that would enable the physical parameters to be determined at any point along the sensing fiber with high sensitivity and spatial resolution, yet within acceptable frequency range for dynamic vibration, and temperature detection. There are many applications, especially in geophysical and mining engineering where simultaneous measurements of vibration and temperature are essential. In this article, recent developments of different hybrid systems for simultaneous vibration, temperature and strain measurements are analyzed based on their operation principles and performance. Then, challenges and limitations of the systems are highlighted for geophysical applications.

Monitoring the Collapse of pH-Sensitive Liposomal Nanocarriers and Environmental pH Simultaneously: A Fluorescence-Based Approach.

PubMed

Draffehn, Sören; Kumke, Michael U

2016-05-02

Nowadays, the encapsulation of therapeutic compounds in so-called carrier systems is a very smart method to achieve protection as well as an improvement of their temporal and spatial distribution. After the successful transport to the point of care, the delivery has to be released under controlled conditions. To monitor the triggered release from the carrier, we investigated different fluorescent probes regarding their response to the pH-induced collapse of pH-sensitive liposomes (pHSLip), which occurs when the environmental pH falls below a critical value. Depending on the probe, the fluorescence decay time as well as fluorescence anisotropy can be used equally as key parameters for monitoring the collapse. Especially the application of a fluorescein labeled fatty acid (fPA) enabled the monitoring of the pHSLips collapse and the pH of its microenvironment simultaneously without interference. Varying the pH in the range of 3 < pH < 9, anisotropy data revealed the critical pH value at which the collapse of the pHSLips occurs. Complementary methods, e.g., fluorescence correlation spectroscopy and dynamic light scattering, supported the analysis based on the decay time and anisotropy. Additional experiments with varying incubation times yielded information on the kinetics of the liposomal collapse.

PRECISE ANGLE MONITOR BASED ON THE CONCEPT OF PENCIL-BEAM INTERFEROMETRY

DOE Office of Scientific and Technical Information (OSTI.GOV)

QIAN,S.; TAKACS,P.

2000-07-30

The precise angle monitoring is a very important metrology task for research, development and industrial applications. Autocollimator is one of the most powerful and widely applied instruments for small angle monitoring, which is based on the principle of geometric optics. In this paper the authors introduce a new precise angle monitoring system, Pencil-beam Angle Monitor (PAM), base on pencil beam interferometry. Its principle of operation is a combination of physical and geometrical optics. The angle calculation method is similar to the autocollimator. However, the autocollimator creates a cross image but the precise pencil-beam angle monitoring system produces an interference fringemore » on the focal plane. The advantages of the PAM are: high angular sensitivity, long-term stability character making angle monitoring over long time periods possible, high measurement accuracy in the order of sub-microradian, simultaneous measurement ability in two perpendicular directions or on two different objects, dynamic measurement possibility, insensitive to the vibration and air turbulence, automatic display, storage and analysis by use of the computer, small beam diameter making the alignment extremely easy and longer test distance. Some test examples are presented.« less

Mobile health-monitoring system through visible light communication.

PubMed

Tan, Yee-Yong; Chung, Wan-Young

2014-01-01

Promising development in the light emitting diode (LED) technology has spurred the interest to adapt LED for both illumination and data transmission. This has fostered the growth of interest in visible light communication (VLC), with on-going research to utilize VLC in various applications. This paper presents a mobile-health monitoring system, where healthcare information such as biomedical signals and patient information are transmitted via the LED lighting. A small and portable receiver module is designed and developed to be attached to the mobile device, providing a seamless monitoring environment. Three different healthcare information including ECG, PPG signals and HL7 text information is transmitted simultaneously, using a single channel VLC. This allows for a more precise and accurate monitoring and diagnosis. The data packet size is carefully designed, to transmit information in a minimal packet error rate. A comprehensive monitoring application is designed and developed through the use of a tablet computer in our study. Monitoring and evaluation such as heart rate and arterial blood pressure measurement can be performed concurrently. Real-time monitoring is demonstrated through experiment, where non-hazardous transmission method can be implemented alongside a portable device for better and safer healthcare service.

A monitor for the laboratory evaluation of control integrity in digital control systems operating in harsh electromagnetic environments

NASA Technical Reports Server (NTRS)

Belcastro, Celeste M.; Fischl, Robert; Kam, Moshe

1992-01-01

This paper presents a strategy for dynamically monitoring digital controllers in the laboratory for susceptibility to electromagnetic disturbances that compromise control integrity. The integrity of digital control systems operating in harsh electromagnetic environments can be compromised by upsets caused by induced transient electrical signals. Digital system upset is a functional error mode that involves no component damage, can occur simultaneously in all channels of a redundant control computer, and is software dependent. The motivation for this work is the need to develop tools and techniques that can be used in the laboratory to validate and/or certify critical aircraft controllers operating in electromagnetically adverse environments that result from lightning, high-intensity radiated fields (HIRF), and nuclear electromagnetic pulses (NEMP). The detection strategy presented in this paper provides dynamic monitoring of a given control computer for degraded functional integrity resulting from redundancy management errors, control calculation errors, and control correctness/effectiveness errors. In particular, this paper discusses the use of Kalman filtering, data fusion, and statistical decision theory in monitoring a given digital controller for control calculation errors.

Real time monitoring of rat liver energy state during ischemia.

PubMed

Barbiro, E; Zurovsky, Y; Mayevsky, A

1998-11-01

Hepatic failure is one of the major problems developed during the posttransplantation period. A possible cause of hepatic failure is the prolonged ischemia induced during the implantation procedure. Hepatic ischemia leads to a reduction in oxygen supply, ATP level decline, liver metabolism impairment, and finally organ failure. The purpose of this study was to estimate the functional state of the liver by monitoring liver blood flow and the mitochondrial NADH redox state simultaneously and continuously during in situ liver ischemia followed by reperfusion. Measurements were performed using the multiprobe developed in our laboratory consisting of fibers for the measurement of relative liver blood flow (laser Doppler flowmetry) and mitochondrial redox state (NADH fluorescence). The experimental procedure included the temporary interruption of blood flow to the liver using three types of ischemia, hepatic artery occlusion, portal vein occlusion, and simultaneous occlusion of hepatic artery and portal vein, followed by a reperfusion period. These preliminary experiments showed a significant decrease in liver blood flow, following the three types of liver ischemia, and a significant increase in NADH levels. The probe used in this study incorporates the advantage of monitoring NADH and liver blood flow simultaneously and continuously from the same area on the surface of the liver. Since each of these two parameters is not calibrated in absolute units, the simultaneous monitoring decreases possible artifacts. Also, it will allow us to determine of the coupling between tissue blood flow and oxidative phosphorylation. It is believed that the measurements of respiratory chain dysfunction might predict organ viability in clinical organ transplantation situations. Using this probe may also help to decrease the variability in liver blood flow monitoring since liver blood flow monitoring is supported simultaneously with the mitochondrial redox state, which supplies the information on liver metabolic and functional state. Copyright 1998 Academic Press.

Observations of transient events with Mini-MegaTORTORA wide-field monitoring system with sub-second temporal resolution

NASA Astrophysics Data System (ADS)

Karpov, S.; Beskin, G.; Biryukov, A.; Bondar, S.; Ivanov, E.; Katkova, E.; Orekhova, N.; Perkov, A.; Sasyuk, V.

2017-07-01

Here we present the summary of first years of operation and the first results of a novel 9-channel wide-field optical monitoring system with sub-second temporal resolution, Mini-MegaTORTORA (MMT-9), which is in operation now at Special Astrophysical Observatory on Russian Caucasus. The system is able to observe the sky simultaneously in either wide (900 square degrees) or narrow (100 square degrees) fields of view, either in clear light or with any combination of color (Johnson-Cousins B, V or R) and polarimetric filters installed, with exposure times ranging from 0.1 s to hundreds of seconds.The real-time system data analysis pipeline performs automatic detection of rapid transient events, both near-Earth and extragalactic. The objects routinely detected by MMT also include faint meteors and artificial satellites.

Mini-MegaTORTORA Wide-Field Monitoring System with Subsecond Temporal Resolution: Observation of Transient Events

NASA Astrophysics Data System (ADS)

Karpov, S.; Beskin, G.; Biryukov, A.; Bondar, S.; Ivanov, E.; Katkova, E.; Orekhova, N.; Perkov, A.; Sasyuk, V.

2017-06-01

Here we present the summary of first years of operation and the first results of a novel 9-channel wide-field optical monitoring system with sub-second temporal resolution, Mini-MegaTORTORA (MMT-9), which is in operation now at Special Astrophysical Observatory on Russian Caucasus. The system is able to observe the sky simultaneously in either wide (˜900 square degrees) or narrow (˜100 square degrees) fields of view, either in clear light or with any combination of color (Johnson-Cousins B, V or R) and polarimetric filters installed, with exposure times ranging from 0.1 s to hundreds of seconds.The real-time system data analysis pipeline performs automatic detection of rapid transient events, both near-Earth and extragalactic. The objects routinely detected by MMT include faint meteors and artificial satellites.

AI mass spectrometers for space shuttle health monitoring

NASA Technical Reports Server (NTRS)

Adams, F. W.

1991-01-01

The facility Hazardous Gas Detection System (HGDS) at Kennedy Space Center (KSC) is a mass spectrometer based gas analyzer. Two instruments make up the HGDS, which is installed in a prime/backup arrangement, with the option of using both analyzers on the same sample line, or on two different lines simultaneously. It is used for monitoring the Shuttle during fuel loading, countdown, and drainback, if necessary. The use of complex instruments, operated over many shifts, has caused problems in tracking the status of the ground support equipment (GSE) and the vehicle. A requirement for overall system reliability has been a major force in the development of Shuttle GSE, and is the ultimate driver in the choice to pursue artificial intelligence (AI) techniques for Shuttle and Advanced Launch System (ALS) mass spectrometer systems. Shuttle applications of AI are detailed.

RT-MATRIX: Measuring Total Organic Carbon by Photocatalytic Oxidation of Volatile Organic Compounds

NASA Technical Reports Server (NTRS)

2008-01-01

Volatile organic compounds (VOCs) inevitably accumulate in enclosed habitats such as the International Space Station and the Crew Exploration Vehicle (CEV) as a result of human metabolism, material off-gassing, and leaking equipment. Some VOCs can negatively affect the quality of the crew's life, health, and performance; and consequently, the success of the mission. Air quality must be closely monitored to ensure a safe living and working environment. Currently, there is no reliable air quality monitoring system that meets NASA's stringent requirements for power, mass, volume, or performance. The ultimate objective of the project -- the development of a Real-Time, Miniaturized, Autonomous Total Risk Indicator System (RT.MATRIX).is to provide a portable, dual-function sensing system that simultaneously determines total organic carbon (TOC) and individual contaminants in air streams.

Prototype positron emission tomography insert with electro-optical signal transmission for simultaneous operation with MRI.

PubMed

Olcott, Peter; Kim, Ealgoo; Hong, Keyjo; Lee, Brian J; Grant, Alexander M; Chang, Chen-Ming; Glover, Gary; Levin, Craig S

2015-05-07

The simultaneous acquisition of PET and MRI data shows promise to provide powerful capabilities to study disease processes in human subjects, guide the development of novel treatments, and monitor therapy response and disease progression. A brain-size PET detector ring insert for an MRI system is being developed that, if successful, can be inserted into any existing MRI system to enable simultaneous PET and MRI images of the brain to be acquired without mutual interference. The PET insert uses electro-optical coupling to relay all the signals from the PET detectors out of the MRI system using analog modulated lasers coupled to fiber optics. Because the fibers use light instead of electrical signals, the PET detector can be electrically decoupled from the MRI making it partially transmissive to the RF field of the MRI. The SiPM devices and low power lasers were powered using non-magnetic MRI compatible batteries. Also, the number of laser-fiber channels in the system was reduced using techniques adapted from the field of compressed sensing. Using the fact that incoming PET data is sparse in time and space, electronic circuits implementing constant weight codes uniquely encode the detector signals in order to reduce the number of electro-optical readout channels by 8-fold. Two out of a total of sixteen electro-optical detector modules have been built and tested with the entire RF-shielded detector gantry for the PET ring insert. The two detectors have been tested outside and inside of a 3T MRI system to study mutual interference effects and simultaneous performance with MRI. Preliminary results show that the PET insert is feasible for high resolution simultaneous PET/MRI imaging for applications in the brain.

Prototype positron emission tomography insert with electro-optical signal transmission for simultaneous operation with MRI

NASA Astrophysics Data System (ADS)

Olcott, Peter; Kim, Ealgoo; Hong, Keyjo; Lee, Brian J.; Grant, Alexander M.; Chang, Chen-Ming; Glover, Gary; Levin, Craig S.

2015-05-01

The simultaneous acquisition of PET and MRI data shows promise to provide powerful capabilities to study disease processes in human subjects, guide the development of novel treatments, and monitor therapy response and disease progression. A brain-size PET detector ring insert for an MRI system is being developed that, if successful, can be inserted into any existing MRI system to enable simultaneous PET and MRI images of the brain to be acquired without mutual interference. The PET insert uses electro-optical coupling to relay all the signals from the PET detectors out of the MRI system using analog modulated lasers coupled to fiber optics. Because the fibers use light instead of electrical signals, the PET detector can be electrically decoupled from the MRI making it partially transmissive to the RF field of the MRI. The SiPM devices and low power lasers were powered using non-magnetic MRI compatible batteries. Also, the number of laser-fiber channels in the system was reduced using techniques adapted from the field of compressed sensing. Using the fact that incoming PET data is sparse in time and space, electronic circuits implementing constant weight codes uniquely encode the detector signals in order to reduce the number of electro-optical readout channels by 8-fold. Two out of a total of sixteen electro-optical detector modules have been built and tested with the entire RF-shielded detector gantry for the PET ring insert. The two detectors have been tested outside and inside of a 3T MRI system to study mutual interference effects and simultaneous performance with MRI. Preliminary results show that the PET insert is feasible for high resolution simultaneous PET/MRI imaging for applications in the brain.

Characterization of a novel bioreactor system for 3D cellular mechanobiology studies.

PubMed

Cook, Colin A; Huri, Pinar Y; Ginn, Brian P; Gilbert-Honick, Jordana; Somers, Sarah M; Temple, Joshua P; Mao, Hai-Quan; Grayson, Warren L

2016-08-01

In vitro engineering systems can be powerful tools for studying tissue development in response to biophysical stimuli as well as for evaluating the functionality of engineered tissue grafts. It has been challenging, however, to develop systems that adequately integrate the application of biomimetic mechanical strain to engineered tissue with the ability to assess functional outcomes in real time. The aim of this study was to design a bioreactor system capable of real-time conditioning (dynamic, uniaxial strain, and electrical stimulation) of centimeter-long 3D tissue engineered constructs simultaneously with the capacity to monitor local strains. The system addresses key limitations of uniform sample loading and real-time imaging capabilities. Our system features an electrospun fibrin scaffold, which exhibits physiologically relevant stiffness and uniaxial alignment that facilitates cell adhesion, alignment, and proliferation. We have demonstrated the capacity for directly incorporating human adipose-derived stromal/stem cells into the fibers during the electrospinning process and subsequent culture of the cell-seeded constructs in the bioreactor. The bioreactor facilitates accurate pre-straining of the 3D constructs as well as the application of dynamic and static uniaxial strains while monitoring bulk construct tensions. The incorporation of fluorescent nanoparticles throughout the scaffolds enables in situ monitoring of local strain fields using fluorescent digital image correlation techniques, since the bioreactor is imaging compatible, and allows the assessment of local sample stiffness and stresses when coupled with force sensor measurements. In addition, the system is capable of measuring the electromechanical coupling of skeletal muscle explants by applying an electrical stimulus and simultaneously measuring the force of contraction. The packaging of these technologies, biomaterials, and analytical methods into a single bioreactor system has produced a powerful tool that will enable improved engineering of functional 3D ligaments, tendons, and skeletal muscles. Biotechnol. Bioeng. 2016;113: 1825-1837. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

New Quality Control Algorithm Based on GNSS Sensing Data for a Bridge Health Monitoring System

PubMed Central

Lee, Jae Kang; Lee, Jae One; Kim, Jung Ok

2016-01-01

This research introduces an improvement plan for the reliability of Global Navigation Satellite System (GNSS) positioning solutions. It should be considered the most suitable methodology in terms of the adjustment and positioning of GNSS in order to maximize the utilization of GNSS applications. Though various studies have been conducted with regards to Bridge Health Monitoring System (BHMS) based on GNSS, the outliers which depend on the signal reception environment could not be considered until now. Since these outliers may be connected to GNSS data collected from major bridge members, which can reduce the reliability of a whole monitoring system through the delivery of false information, they should be detected and eliminated in the previous adjustment stage. In this investigation, the Detection, Identification, Adaptation (DIA) technique was applied and implemented through an algorithm. Moreover, it can be directly applied to GNSS data collected from long span cable stayed bridges and most of outliers were efficiently detected and eliminated simultaneously. By these effects, the reliability of GNSS should be enormously improved. Improvement on GNSS positioning accuracy is directly linked to the safety of bridges itself, and at the same time, the reliability of monitoring systems in terms of the system operation can also be increased. PMID:27240375

New Quality Control Algorithm Based on GNSS Sensing Data for a Bridge Health Monitoring System.

PubMed

Lee, Jae Kang; Lee, Jae One; Kim, Jung Ok

2016-05-27

This research introduces an improvement plan for the reliability of Global Navigation Satellite System (GNSS) positioning solutions. It should be considered the most suitable methodology in terms of the adjustment and positioning of GNSS in order to maximize the utilization of GNSS applications. Though various studies have been conducted with regards to Bridge Health Monitoring System (BHMS) based on GNSS, the outliers which depend on the signal reception environment could not be considered until now. Since these outliers may be connected to GNSS data collected from major bridge members, which can reduce the reliability of a whole monitoring system through the delivery of false information, they should be detected and eliminated in the previous adjustment stage. In this investigation, the Detection, Identification, Adaptation (DIA) technique was applied and implemented through an algorithm. Moreover, it can be directly applied to GNSS data collected from long span cable stayed bridges and most of outliers were efficiently detected and eliminated simultaneously. By these effects, the reliability of GNSS should be enormously improved. Improvement on GNSS positioning accuracy is directly linked to the safety of bridges itself, and at the same time, the reliability of monitoring systems in terms of the system operation can also be increased.

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis.

PubMed

Gao, Wei; Emaminejad, Sam; Nyein, Hnin Yin Yin; Challa, Samyuktha; Chen, Kevin; Peck, Austin; Fahad, Hossain M; Ota, Hiroki; Shiraki, Hiroshi; Kiriya, Daisuke; Lien, Der-Hsien; Brooks, George A; Davis, Ronald W; Javey, Ali

2016-01-28

Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis

NASA Astrophysics Data System (ADS)

Gao, Wei; Emaminejad, Sam; Nyein, Hnin Yin Yin; Challa, Samyuktha; Chen, Kevin; Peck, Austin; Fahad, Hossain M.; Ota, Hiroki; Shiraki, Hiroshi; Kiriya, Daisuke; Lien, Der-Hsien; Brooks, George A.; Davis, Ronald W.; Javey, Ali

2016-01-01

Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual’s state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.

High-Resolution, Non-Invasive Imaging of Upper Vocal Tract Articulators Compatible with Human Brain Recordings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bouchard, Kristofer E.; Conant, David F.; Anumanchipalli, Gopala K.

A complete neurobiological understanding of speech motor control requires determination of the relationship between simultaneously recorded neural activity and the kinematics of the lips, jaw, tongue, and larynx. Many speech articulators are internal to the vocal tract, and therefore simultaneously tracking the kinematics of all articulators is nontrivial-especially in the context of human electrophysiology recordings. Here, we describe a noninvasive, multi-modal imaging system to monitor vocal tract kinematics, demonstrate this system in six speakers during production of nine American English vowels, and provide new analysis of such data. Classification and regression analysis revealed considerable variability in the articulator-to-acoustic relationship acrossmore » speakers. Non-negative matrix factorization extracted basis sets capturing vocal tract shapes allowing for higher vowel classification accuracy than traditional methods. Statistical speech synthesis generated speech from vocal tract measurements, and we demonstrate perceptual identification. We demonstrate the capacity to predict lip kinematics from ventral sensorimotor cortical activity. These results demonstrate a multi-modal system to non-invasively monitor articulator kinematics during speech production, describe novel analytic methods for relating kinematic data to speech acoustics, and provide the first decoding of speech kinematics from electrocorticography. These advances will be critical for understanding the cortical basis of speech production and the creation of vocal prosthetics.« less

High-Resolution, Non-Invasive Imaging of Upper Vocal Tract Articulators Compatible with Human Brain Recordings

PubMed Central

Anumanchipalli, Gopala K.; Dichter, Benjamin; Chaisanguanthum, Kris S.; Johnson, Keith; Chang, Edward F.

2016-01-01

A complete neurobiological understanding of speech motor control requires determination of the relationship between simultaneously recorded neural activity and the kinematics of the lips, jaw, tongue, and larynx. Many speech articulators are internal to the vocal tract, and therefore simultaneously tracking the kinematics of all articulators is nontrivial—especially in the context of human electrophysiology recordings. Here, we describe a noninvasive, multi-modal imaging system to monitor vocal tract kinematics, demonstrate this system in six speakers during production of nine American English vowels, and provide new analysis of such data. Classification and regression analysis revealed considerable variability in the articulator-to-acoustic relationship across speakers. Non-negative matrix factorization extracted basis sets capturing vocal tract shapes allowing for higher vowel classification accuracy than traditional methods. Statistical speech synthesis generated speech from vocal tract measurements, and we demonstrate perceptual identification. We demonstrate the capacity to predict lip kinematics from ventral sensorimotor cortical activity. These results demonstrate a multi-modal system to non-invasively monitor articulator kinematics during speech production, describe novel analytic methods for relating kinematic data to speech acoustics, and provide the first decoding of speech kinematics from electrocorticography. These advances will be critical for understanding the cortical basis of speech production and the creation of vocal prosthetics. PMID:27019106

High-Resolution, Non-Invasive Imaging of Upper Vocal Tract Articulators Compatible with Human Brain Recordings

DOE PAGES

Bouchard, Kristofer E.; Conant, David F.; Anumanchipalli, Gopala K.; ...

2016-03-28

A complete neurobiological understanding of speech motor control requires determination of the relationship between simultaneously recorded neural activity and the kinematics of the lips, jaw, tongue, and larynx. Many speech articulators are internal to the vocal tract, and therefore simultaneously tracking the kinematics of all articulators is nontrivial-especially in the context of human electrophysiology recordings. Here, we describe a noninvasive, multi-modal imaging system to monitor vocal tract kinematics, demonstrate this system in six speakers during production of nine American English vowels, and provide new analysis of such data. Classification and regression analysis revealed considerable variability in the articulator-to-acoustic relationship acrossmore » speakers. Non-negative matrix factorization extracted basis sets capturing vocal tract shapes allowing for higher vowel classification accuracy than traditional methods. Statistical speech synthesis generated speech from vocal tract measurements, and we demonstrate perceptual identification. We demonstrate the capacity to predict lip kinematics from ventral sensorimotor cortical activity. These results demonstrate a multi-modal system to non-invasively monitor articulator kinematics during speech production, describe novel analytic methods for relating kinematic data to speech acoustics, and provide the first decoding of speech kinematics from electrocorticography. These advances will be critical for understanding the cortical basis of speech production and the creation of vocal prosthetics.« less

Simultaneous and independent optical impairments monitoring using singular spectrum analysis of asynchronously sampled signal amplitudes

NASA Astrophysics Data System (ADS)

Guesmi, Latifa; Menif, Mourad

2015-09-01

Optical performance monitoring (OPM) becomes an inviting topic in high speed optical communication networks. In this paper, a novel technique of OPM based on a new elaborated computation approach of singular spectrum analysis (SSA) for time series prediction is presented. Indeed, various optical impairments among chromatic dispersion (CD), polarization mode dispersion (PMD) and amplified spontaneous emission (ASE) noise are a major factors limiting quality of transmission data in the systems with data rates lager than 40 Gbit/s. This technique proposed an independent and simultaneous multi-impairments monitoring, where we used SSA of time series analysis and forecasting. It has proven their usefulness in the temporal analysis of short and noisy time series in several fields, that it is based on the singular value decomposition (SVD). Also, advanced optical modulation formats (100 Gbit/s non-return-to zero dual-polarization quadrature phase shift keying (NRZ-DP-QPSK) and 160 Gbit/s DP-16 quadrature amplitude modulation (DP-16QAM)) offering high spectral efficiencies have been successfully employed by analyzing their asynchronously sampled amplitude. The simulated results proved that our method is efficient on CD, first-order PMD, Q-factor and OSNR monitoring, which enabled large monitoring ranges, the CD in the range of 170-1700 ps/nm.Km and 170-1110 ps/nm.Km for 100 Gbit/s NRZ-DP-QPSK and 160 Gbit/s DP-16QAM respectively, and also the DGD up to 20 ps is monitored. We could accurately monitor the OSNR in the range of 10-40 dB with monitoring error remains less than 1 dB in the presence of large accumulated CD.

Remote diagnosis server

NASA Technical Reports Server (NTRS)

Deb, Somnath (Inventor); Ghoshal, Sudipto (Inventor); Malepati, Venkata N. (Inventor); Kleinman, David L. (Inventor); Cavanaugh, Kevin F. (Inventor)

2004-01-01

A network-based diagnosis server for monitoring and diagnosing a system, the server being remote from the system it is observing, comprises a sensor for generating signals indicative of a characteristic of a component of the system, a network-interfaced sensor agent coupled to the sensor for receiving signals therefrom, a broker module coupled to the network for sending signals to and receiving signals from the sensor agent, a handler application connected to the broker module for transmitting signals to and receiving signals therefrom, a reasoner application in communication with the handler application for processing, and responding to signals received from the handler application, wherein the sensor agent, broker module, handler application, and reasoner applications operate simultaneously relative to each other, such that the present invention diagnosis server performs continuous monitoring and diagnosing of said components of the system in real time. The diagnosis server is readily adaptable to various different systems.

A novel real-time health monitoring system for unmanned vehicles

NASA Astrophysics Data System (ADS)

Zhang, David C.; Ouyang, Lien; Qing, Peter; Li, Irene

2008-04-01

Real-time monitoring the status of in-service structures such as unmanned vehicles can provide invaluable information to detect the damages to the structures on time. The unmanned vehicles can be maintained and repaired in time if such damages are found. One typical cause of damages of unmanned vehicles is from impacts caused by bumping into some obstacles or being hit by some objects such as hostile fire. This paper introduces a novel impact event sensing system that can detect the location of the impact events and the force-time history of the impact events. The system consists of the Piezo-electric sensor network, the hardware platform and the analysis software. The new customized battery-powered impact event sensing system supports up to 64-channel parallel data acquisition. It features an innovative low-power hardware trigger circuit that monitors 64 channels simultaneously. The system is in the sleep mode most of the time. When an impact event happens, the system will wake up in micro-seconds and detect the impact location and corresponding force-time history. The system can be combined with the SMART sensing system to further evaluate the impact damage severity.

STATS: a unique high speed, multiple channel, real-time data acquisition system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ross, F.A.; O'Connell, L.; Trellue, R.

1980-01-01

A Stand Alone Test System, called STATS, was developd to acquire and analyze data from as many as 120 analog channels. STATS is used in testing weapon systems under simulated environments at a laboratory in Texas. Some analog channels are sampled every 10 microseconds, but most are digitized every 100 microseconds. STATS features hardware data compression and a first-in-first-out buffer for each channel. It has also provided a way for the test configuration to be controlled by the diskette files that contain the test specifications. The analysis specifications are also predefined in diskette files keyed to the particular test type.more » The techniques used are applicable when many channels must be monitored simultaneously, channel activity comes in spurts separated by long quiet periods, and more than a few channels experience nearly simultaneous bursts of activity.« less

Simultaneous and quasi-independent strain and temperature sensor based on microstructured optical fiber

NASA Astrophysics Data System (ADS)

Lopez-Aldaba, A.; Auguste, J.-L.; Jamier, R.; Roy, P.; Lopez-Amo, M.

2017-04-01

In this paper, a new sensor system for simultaneous and quasi-independent strain and temperature measurements is presented. The interrogation of the sensing head has been carried out by monitoring the FFT phase variations of two of the microstructured optical fiber (MOF) cavity interference frequencies. This method is independent of the signal amplitude and also avoids the need to track the wavelength evolution in the spectrum, which can be a handicap when there are multiple interference frequency components with different sensitivities. The sensor is operated within a range of temperature of 30°C-75°C, and 380μɛ of maximum strain were applied; being the sensitivities achieved of 127.5pm/°C and -19.1pm/μɛ respectively. Because the system uses an optical interrogator as unique active element, the system presents a cost-effective feature.

FTIR gas analysis with improved sensitivity and selectivity for CWA and TIC detection

NASA Astrophysics Data System (ADS)

Phillips, Charles M.; Tan, Huwei

2010-04-01

This presentation describes the use of an FTIR (Fourier Transform Infrared)-based spectrometer designed to continuously monitor ambient air for the presence of chemical warfare agents (CWAs) and toxic industrial chemicals (TICs). The necessity of a reliable system capable of quickly and accurately detecting very low levels of CWAs and TICs while simultaneously retaining a negligible false alarm rate will be explored. Technological advancements in FTIR sensing have reduced noise while increasing selectivity and speed of detection. These novel analyzer design characteristics are discussed in detail and descriptions are provided which show how optical throughput, gas cell form factor, and detector response are optimized. The hardware and algorithms described here will explain why this FTIR system is very effective for the simultaneous detection and speciation of a wide variety of toxic compounds at ppb concentrations. Analytical test data will be reviewed demonstrating the system's sensitivity to and selectivity for specific CWAs and TICs; this will include recent data acquired as part of the DHS ARFCAM (Autonomous Rapid Facility Chemical Agent Monitor) project. These results include analyses of the data from live agent testing for the determination of CWA detection limits, immunity to interferences, detection times, residual noise analysis and false alarm rates. Sensing systems such as this are critical for effective chemical hazard identification which is directly relevant to the CBRNE community.

A Waveform Archiving System for the GE Solar 8000i Bedside Monitor.

PubMed

Fanelli, Andrea; Jaishankar, Rohan; Filippidis, Aristotelis; Holsapple, James; Heldt, Thomas

2018-01-01

Our objective was to develop, deploy, and test a data-acquisition system for the reliable and robust archiving of high-resolution physiological waveform data from a variety of bedside monitoring devices, including the GE Solar 8000i patient monitor, and for the logging of ancillary clinical and demographic information. The data-acquisition system consists of a computer-based archiving unit and a GE Tram Rac 4A that connects to the GE Solar 8000i monitor. Standard physiological front-end sensors connect directly to the Tram Rac, which serves as a port replicator for the GE monitor and provides access to these waveform signals through an analog data interface. Together with the GE monitoring data streams, we simultaneously collect the cerebral blood flow velocity envelope from a transcranial Doppler ultrasound system and a non-invasive arterial blood pressure waveform along a common time axis. All waveform signals are digitized and archived through a LabView-controlled interface that also allows for the logging of relevant meta-data such as clinical and patient demographic information. The acquisition system was certified for hospital use by the clinical engineering team at Boston Medical Center, Boston, MA, USA. Over a 12-month period, we collected 57 datasets from 11 neuro-ICU patients. The system provided reliable and failure-free waveform archiving. We measured an average temporal drift between waveforms from different monitoring devices of 1 ms every 66 min of recorded data. The waveform acquisition system allows for robust real-time data acquisition, processing, and archiving of waveforms. The temporal drift between waveforms archived from different devices is entirely negligible, even for long-term recording.

Development of an autonomous, wireless pH and temperature sensing system for monitoring pig meat quality.

PubMed

Frisby, June; Raftery, Declan; Kerry, Joe P; Diamond, Dermot

2005-06-01

This paper focuses on the development of a unique wireless pH and temperature monitoring system to assess pig meat quality. Pale, soft and exudative (PSE) pig meat continues to be a major problem in the pig meat industry today. The PSE condition in pork is related to a number of factors including genetics, pre-slaughter stress and insufficient chilling of pig carcasses, which cause a rapid rate of glycolysis post-mortem (<1h). As a result the pH drops to low levels while the muscle temperature is still high. A wireless dual channel system that monitors pH and temperature simultaneously has been developed to provide pH and temperature data of the carcass during the first 24h after slaughter. We have demonstrated that this approach can distinguish in real time, pH and temperature profiles that are 'non-normal', and identify carcasses that are PSE positive quickly and easily.

Advantages and difficulties of implementation of flat-panel multimedia monitoring system in a surgical MRI suite

NASA Astrophysics Data System (ADS)

Deckard, Michael; Ratib, Osman M.; Rubino, Gregory

2002-05-01

Our project was to design and implement a ceiling-mounted multi monitor display unit for use in a high-field MRI surgical suite. The system is designed to simultaneously display images/data from four different digital and/or analog sources with: minimal interference from the adjacent high magnetic field, minimal signal-to-noise/artifact contribution to the MRI images and compliance with codes and regulations for the sterile neuro-surgical environment. Provisions were also made to accommodate the importing and exporting of video information via PACS and remote processing/display for clinical and education uses. Commercial fiber optic receivers/transmitters were implemented along with supporting video processing and distribution equipment to solve the video communication problem. A new generation of high-resolution color flat panel displays was selected for the project. A custom-made monitor mount and in-suite electronics enclosure was designed and constructed at UCLA. Difficulties with implementing an isolated AC power system are discussed and a work-around solution presented.

Instrumenting free-swimming dolphins echolocating in open water.

PubMed

Martin, Stephen W; Phillips, Michael; Bauer, Eric J; Moore, Patrick W; Houser, Dorian S

2005-04-01

Dolphins within the Navy Marine Mammal Program use echolocation to effectively locate underwater mines. They currently outperform manmade systems at similar tasks, particularly in cluttered environments and on buried targets. In hopes of improving manmade mine-hunting sonar systems, two instrumentation packages were developed to monitor free-swimming dolphin motion and echolocation during open-water target detection tasks. The biosonar measurement tool (BMT) is carried by a dolphin and monitors underwater position and attitude while simultaneously recording echolocation clicks and returning echoes through high-gain binaural receivers. The instrumented mine simulator (IMS) is a modified bottom target that monitors echolocation signals arriving at the target during ensonification. Dolphin subjects were trained to carry the BMT in open-bay bottom-object target searches in which the IMS could serve as a bottom object. The instrumentation provides detailed data that reveal hereto-unavailable information on the search strategies of free-swimming dolphins conducting open-water, bottom-object search tasks with echolocation.

3D Holographic Observatory for Long-term Monitoring of Complex Behaviors in Drosophila

NASA Astrophysics Data System (ADS)

Kumar, S. Santosh; Sun, Yaning; Zou, Sige; Hong, Jiarong

2016-09-01

Drosophila is an excellent model organism towards understanding the cognitive function, aging and neurodegeneration in humans. The effects of aging and other long-term dynamics on the behavior serve as important biomarkers in identifying such changes to the brain. In this regard, we are presenting a new imaging technique for lifetime monitoring of Drosophila in 3D at spatial and temporal resolutions capable of resolving the motion of limbs and wings using holographic principles. The developed system is capable of monitoring and extracting various behavioral parameters, such as ethograms and spatial distributions, from a group of flies simultaneously. This technique can image complicated leg and wing motions of flies at a resolution, which allows capturing specific landing responses from the same data set. Overall, this system provides a unique opportunity for high throughput screenings of behavioral changes in 3D over a long term in Drosophila.

Instrumenting free-swimming dolphins echolocating in open water

NASA Astrophysics Data System (ADS)

Martin, Stephen W.; Phillips, Michael; Bauer, Eric J.; Moore, Patrick W.; Houser, Dorian S.

2005-04-01

Dolphins within the Navy Marine Mammal Program use echolocation to effectively locate underwater mines. They currently outperform manmade systems at similar tasks, particularly in cluttered environments and on buried targets. In hopes of improving manmade mine-hunting sonar systems, two instrumentation packages were developed to monitor free-swimming dolphin motion and echolocation during open-water target detection tasks. The biosonar measurement tool (BMT) is carried by a dolphin and monitors underwater position and attitude while simultaneously recording echolocation clicks and returning echoes through high-gain binaural receivers. The instrumented mine simulator (IMS) is a modified bottom target that monitors echolocation signals arriving at the target during ensonification. Dolphin subjects were trained to carry the BMT in open-bay bottom-object target searches in which the IMS could serve as a bottom object. The instrumentation provides detailed data that reveal hereto-unavailable information on the search strategies of free-swimming dolphins conducting open-water, bottom-object search tasks with echolocation. .

Combined multi-distance frequency domain and diffuse correlation spectroscopy system with simultaneous data acquisition and real-time analysis.

PubMed

Carp, Stefan A; Farzam, Parisa; Redes, Norin; Hueber, Dennis M; Franceschini, Maria Angela

2017-09-01

Frequency domain near infrared spectroscopy (FD-NIRS) and diffuse correlation spectroscopy (DCS) have emerged as synergistic techniques for the non-invasive assessment of tissue health. Combining FD-NIRS oximetry with DCS measures of blood flow, the tissue oxygen metabolic rate can be quantified, a parameter more closely linked to underlying physiology and pathology than either NIRS or DCS estimates alone. Here we describe the first commercially available integrated instrument, called the "MetaOx", designed to enable simultaneous FD-NIRS and DCS measurements at rates of 10 + Hz, and offering real-time data evaluation. We show simultaneously acquired characterization data demonstrating performance equivalent to individual devices and sample in vivo measurements of pulsation resolved blood flow, forearm occlusion hemodynamic changes and muscle oxygen metabolic rate monitoring during stationary bike exercise.

Combined multi-distance frequency domain and diffuse correlation spectroscopy system with simultaneous data acquisition and real-time analysis

PubMed Central

Carp, Stefan A.; Farzam, Parisa; Redes, Norin; Hueber, Dennis M.; Franceschini, Maria Angela

2017-01-01

Frequency domain near infrared spectroscopy (FD-NIRS) and diffuse correlation spectroscopy (DCS) have emerged as synergistic techniques for the non-invasive assessment of tissue health. Combining FD-NIRS oximetry with DCS measures of blood flow, the tissue oxygen metabolic rate can be quantified, a parameter more closely linked to underlying physiology and pathology than either NIRS or DCS estimates alone. Here we describe the first commercially available integrated instrument, called the “MetaOx”, designed to enable simultaneous FD-NIRS and DCS measurements at rates of 10 + Hz, and offering real-time data evaluation. We show simultaneously acquired characterization data demonstrating performance equivalent to individual devices and sample in vivo measurements of pulsation resolved blood flow, forearm occlusion hemodynamic changes and muscle oxygen metabolic rate monitoring during stationary bike exercise. PMID:29026684

Model-Based, Noninvasive Monitoring of Intracranial Pressure

DTIC Science & Technology

2013-07-01

patients. A physiologically based model relates ICP to simultaneously measured waveforms of arterial blood pressure ( ABP ), obtained via radial... ABP and CBFV are currently measured as the clinical standard of care. The project’s major accomplishments include: assembling a suitable system for...synchronized arterial blood pressure ( ABP ) and cerebral blood flow velocity (CBFV) waveform measurements that can be obtained quite routinely. Our processing

Structural Monitoring of Metro Infrastructure during Shield Tunneling Construction

PubMed Central

Ran, L.; Ye, X. W.; Ming, G.; Dong, X. B.

2014-01-01

Shield tunneling construction of metro infrastructure will continuously disturb the soils. The ground surface will be subjected to uplift or subsidence due to the deep excavation and the extrusion and consolidation of the soils. Implementation of the simultaneous monitoring with the shield tunnel construction will provide an effective reference in controlling the shield driving, while how to design and implement a safe, economic, and effective structural monitoring system for metro infrastructure is of great importance and necessity. This paper presents the general architecture of the shield construction of metro tunnels as well as the procedure of the artificial ground freezing construction of the metro-tunnel cross-passages. The design principles for metro infrastructure monitoring of the shield tunnel intervals in the Hangzhou Metro Line 1 are introduced. The detailed monitoring items and the specified alarming indices for construction monitoring of the shield tunneling are addressed, and the measured settlement variations at different monitoring locations are also presented. PMID:25032238

A sensitive LC-MS/MS method for the simultaneous determination of amoxicillin and ambroxol in human plasma with segmental monitoring.

PubMed

Dong, Xin; Ding, Li; Cao, Xiaomei; Jiang, Liyuan; Zhong, Shuisheng

2013-04-01

Amoxicillin (AMO) degrades in plasma at room temperature and readily undergoes hydrolysis by the plasma amidase. In this paper, a novel, rapid and sensitive LC-MS/MS method operated in segmental and multiple reaction monitoring has been developed for the simultaneous determination of amoxicillin and ambroxol in human plasma. The degradation of amoxicillin in plasma was well prevented by immediate addition of 20 μL glacial acetic acid to 200 μL aliquot of freshly collected plasma samples before storage at -80°C. The sensitivity of the method was improved with segmental monitoring of the analytes, and lower limits of quantitation of 0.5 ng/mL for ambroxol and 5 ng/mL for amoxicillin were obtained. The sensitivity of our method was five times better than those of the existing methods. Furthermore, the mass response saturation problem with amoxicillin was avoided by diluting the deproteinized plasma samples with water before injection into the LC-MS/MS system. The method was successfully employed in a pharmacokinetic study of the compound amoxicillin and ambroxol hydrochloride tablets. Copyright © 2012 John Wiley & Sons, Ltd.

A pulse coding and decoding strategy to perform Lamb wave inspections using simultaneously multiple actuators

NASA Astrophysics Data System (ADS)

De Marchi, Luca; Marzani, Alessandro; Moll, Jochen; Kudela, Paweł; Radzieński, Maciej; Ostachowicz, Wiesław

2017-07-01

The performance of Lamb wave based monitoring systems, both in terms of diagnosis time and data complexity, can be enhanced by increasing the number of transducers used to actuate simultaneously the guided waves in the inspected medium. However, in case of multiple simultaneously-operated actuators the interference among the excited wave modes within the acquired signals has to be considered for the further processing. To this aim, in this work a code division strategy based on the Warped Frequency Transform is presented. At first, the proposed procedure encodes actuation pulses using Gold sequences. Next, for each considered actuator the acquired signals are compensated from dispersion by cross correlating the warped version of the actuated and received signals. Compensated signals form the base for a final wavenumber imaging meant at emphasizing defects and or anomalies by removing incident wavefield and edge reflections. The proposed strategy is tested numerically, and validated through an experiment in which guided waves are actuated in a plate by four piezoelectric transducers operating simultaneously.

Hyperspectral imaging to monitor simultaneously multiple protein subtypes and live track their spatial dynamics: a new platform to screen drugs for CNS diseases

NASA Astrophysics Data System (ADS)

Labrecque, S.; Sylvestre, J.-P.; Marcet, S.; Mangiarini, F.; Verhaegen, M.; De Koninck, P.; Blais-Ouellette, S.

2015-03-01

In the past decade, the efficacy of existing therapies and the discovery of innovative treatments for Central Nervous System (CNS) diseases have been limited by the lack of appropriate methods to investigate complex molecular processes at the synaptic level. In order to better understand the fundamental mechanisms that regulate diseases of the CNS, a fast fluorescence hyperspectral imaging platform was designed to track simultaneously various neurotransmitter receptors trafficking in and out of synapses. With this hyperspectral imaging platform, it was possible to image simultaneously five different synaptic proteins, including subtypes of glutamate receptors (mGluR, NMDAR, AMPAR), postsynaptic density proteins, and signaling proteins. This new imaging platform allows fast simultaneous acquisitions of at least five fluorescent markers in living neurons with a high spatial resolution. This technique provides an effective method to observe several synaptic proteins at the same time, thus study how drugs for CNS impact the spatial dynamics of these proteins.

Spacelab Life Sciences-1 electrical diagnostic expert system

NASA Technical Reports Server (NTRS)

Kao, C. Y.; Morris, W. S.

1989-01-01

The Spacelab Life Sciences-1 (SLS-1) Electrical Diagnostic (SLED) expert system is a continuous, real time knowledge-based system to monitor and diagnose electrical system problems in the Spacelab. After fault isolation, the SLED system provides corrective procedures and advice to the ground-based console operator. The SLED system updates its knowledge about the status of Spacelab every 3 seconds. The system supports multiprocessing of malfunctions and allows multiple failures to be handled simultaneously. Information which is readily available via a mouse click includes: general information about the system and each component, the electrical schematics, the recovery procedures of each malfunction, and an explanation of the diagnosis.

Gas Sensor for Volatile Anesthetic Agents Based on Raman Scattering

NASA Astrophysics Data System (ADS)

Schlüter, Sebastian; Popovska-Leipertz, Nadejda; Seeger, Thomas; Leipertz, Alfred

Continuous monitoring of respiratory and anesthetic gases during a surgery is of vital importance for the patient safety. Commonly the gas composition is determined by gas chromatography or a combination of IR-spectroscopy and electrochemical sensors. This study presents a concept for an optical sensor based on spontaneous Raman scattering which offers several advantages compared to established systems. All essential components can be detected simultaneously, no sample preparation is necessary and it provides fast response times. To reach the performance of a commonly used gas monitor signal gain has to be increased e.g. by using a multi pass setup.

A high-performance liquid chromatography micromethod for the simultaneous determination of vigabatrin and gabapentin in serum.

PubMed

Ratnaraj, N; Patsalos, P N

1998-08-01

A gradient high-performance liquid chromatography micromethod is described for the simultaneous quantitation of vigabatrin and gabapentin in human serum. Chromatography was performed using a 125- x 3-mm ID Hypersil BDS C-18 column with a 3-microm mini-bore, eluted with a gradient system comprised of phosphate buffer (pH 6.5)-acetonitrile-methanol-water at a flow rate of 0.45 ml/minute. The column eluent was monitored on a fluorescence detector using excitation and emission wavelengths of 340 and 440 nm, respectively. The lower limit of quantitation for vigabatrin and for gabapentin was 5 micromol/l, and the within-batch and between-batch coefficients of variation were <5%. No interference from commonly prescribed antiepileptic drugs (carbamazepine and its metabolite carbamazepine epoxide, oxcarbazepine and its metabolite 10-hydroxycarbazepine, ethosuximide, lamotrigine, phenobarbitone, phenytoin, primidone, and valproic acid) was observed; thus, the method can be used to monitor vigabatrin and gabapentin in patients on polytherapy antiepileptic drug regimens.

Integration of Diagnostics into Ground Equipment Study. Volume 1

DTIC Science & Technology

2004-07-30

Marine Corps V-22, CH-53E, MH-53E, SH- 60B, MH- 60S /R, AH-1Z and UH -1Y aircraft. In addition, 30 systems are in delivery to the US Army Aviation Applied...simultaneous) can be connected to the VMEP system, which is based on a PC-104 platform and a 233MHz processor. The AH-64 Apache and UH - 60 Blackhawk are outfitted...34A Model-Based Health and Usage Monitoring and Diagnostic System for the UH - 60 Helicopter," Proceedings of the American Helicopter Society 57th

Imaging System for Vaginal Surgery.

PubMed

Taylor, G Bernard; Myers, Erinn M

2015-12-01

The vaginal surgeon is challenged with performing complex procedures within a surgical field of limited light and exposure. The video telescopic operating microscope is an illumination and imaging system that provides visualization during open surgical procedures with a limited field of view. The imaging system is positioned within the surgical field and then secured to the operating room table with a maneuverable holding arm. A high-definition camera and Xenon light source allow transmission of the magnified image to a high-definition monitor in the operating room. The monitor screen is positioned above the patient for the surgeon and assistants to view real time throughout the operation. The video telescopic operating microscope system was used to provide surgical illumination and magnification during total vaginal hysterectomy and salpingectomy, midurethral sling, and release of vaginal scar procedures. All procedures were completed without complications. The video telescopic operating microscope provided illumination of the vaginal operative field and display of the magnified image onto high-definition monitors in the operating room for the surgeon and staff to simultaneously view the procedures. The video telescopic operating microscope provides high-definition display, magnification, and illumination during vaginal surgery.

Clinical applications of commercially available video recording and monitoring systems: inexpensive, high-quality video recording and monitoring systems for endoscopy and microsurgery.

PubMed

Tsunoda, Koichi; Tsunoda, Atsunobu; Ishimoto, ShinnIchi; Kimura, Satoko

2006-01-01

The exclusive charge-coupled device (CCD) camera system for the endoscope and electronic fiberscopes are in widespread use. However, both are usually stationary in an office or examination room, and a wheeled cart is needed for mobility. The total costs of the CCD camera system and electronic fiberscopy system are at least US Dollars 10,000 and US Dollars 30,000, respectively. Recently, the performance of audio and visual instruments has improved dramatically, with a concomitant reduction in their cost. Commercially available CCD video cameras with small monitors have become common. They provide excellent image quality and are much smaller and less expensive than previous models. The authors have developed adaptors for the popular mini-digital video (mini-DV) camera. The camera also provides video and acoustic output signals; therefore, the endoscopic images can be viewed on a large monitor simultaneously. The new system (a mini-DV video camera and an adaptor) costs only US Dollars 1,000. Therefore, the system is both cost-effective and useful for the outpatient clinic or casualty setting, or on house calls for the purpose of patient education. In the future, the authors plan to introduce the clinical application of a high-vision camera and an infrared camera as medical instruments for clinical and research situations.

Study on the weighing system based on optical fiber Bragg grating

NASA Astrophysics Data System (ADS)

Wang, Xiaona; Yu, Qingxu; Li, Yefang

2010-10-01

The optical fiber sensor based on wavelength demodulation such as fiber Bragg grating(FBG), with merits of immunity to electromagnetic interference, low drift and high precision, has been widely used in many areas, such as structural health monitoring and smart materials, and the wavelength demodulation system was also studied widely. In the paper, a weighing system based on FBG was studied. The optical source is broadband Erbium-doped fiber ring laser with a spectral range of 1500~1600nm and optical power of 2mW; A Fabry-Perot Etalon with orientation precision of 1pm was adopted as real-time wavelength calibration for the swept laser; and multichannel high resolution simultaneous sampling card was used in the system to acquire sensing signals simultaneously, thus high-resolution and real-time calibration of sweep-wavelength can be achieved. The FBG was adhered to a cantilever beam and the Bragg wavelength was demodulated with the system. The weighing system was done after calibrated with standard weight. Experimental results show that the resolution of the weighing system is 0.5 g with a full scale of 2Kg.

Mini-Mega-TORTORA wide-field monitoring system with sub-second temporal resolution: first year of operation

NASA Astrophysics Data System (ADS)

Karpov, S.; Beskin, G.; Biryukov, A.; Bondar, S.; Ivanov, E.; Katkova, E.; Perkov, A.; Sasyuk, V.

2016-12-01

Here we present the summary of first years of operation and the first results of a novel 9-channel wide-field optical monitoring system with sub-second temporal resolution, Mini-Mega-TORTORA (MMT-9), which is in operation now at Special Astrophysical Observatory on Russian Caucasus. The system is able to observe the sky simultaneously in either wide (˜900 square degrees) or narrow (˜100 square degrees) fields of view, either in clear light or with any combination of color (Johnson-Cousins B, V or R) and polarimetric filters installed, with exposure times ranging from 0.1 s to hundreds of seconds. The real-time system data analysis pipeline performs automatic detection of rapid transient events, both near-Earth and extragalactic. The objects routinely detected by MMT include faint meteors and artificial satellites. The pipeline for a longer time scales variability analysis is still in development.

Mini-MegaTORTORA wide-field monitoring system with sub-second temporal resolution: observation of transient events

NASA Astrophysics Data System (ADS)

Karpov, S.; Beskin, G.; Biryukov, A.; Bondar, S.; Ivanov, E.; Katkova, E.; Perkov, A.; Sasyuk, V.

2016-06-01

Here we present a summary of first years of operation and first results of a novel 9-channel wide-field optical monitoring system with sub-second temporal resolution, Mini-MegaTORTORA (MMT-9), which is in operation now at Special Astrophysical Observatory on Russian Caucasus. The system is able to observe the sky simultaneously in either wide (~900 square degrees) or narrow (~100 square degrees) fields of view, either in clear light or with any combination of color (Johnson-Cousins B, V or R) and polarimetric filters installed, with exposure times ranging from 0.1 s to hundreds of seconds. The real-time system data analysis pipeline performs automatic detection of rapid transient events, both near-Earth and extragalactic. The objects routinely detected by MMT include faint meteors and artificial satellites. The pipeline for a longer time scales variability analysis is still in development.

Optical transient monitor

NASA Astrophysics Data System (ADS)

Bernas, Martin; Páta, Petr; Hudec, René; Soldán, Jan; Rezek, Tomáš; Castro-Tirado, Alberto J.

1998-05-01

Although there are several optical GRB follow-up systems in operation and/or in development, some of them with a very short response time, they will never be able to provide true simultaneous (no delay) and pre-burst optical data for GRBs. We report on the development and tests of a monitoring experiment expected to be put into test operation in 1998. The system should detect Optical Transients down to mag 6-7 (few seconds duration assumed) over a wide field of view. The system is based on the double CCD wide-field cameras ST8. For the real time evaluation of the signal from both cameras, two TMS 320C40 processors are used. Using two channels differing in spectral sensitivity and processing of temporal sequence of images allows us to eliminate man-made objects and defects of the CCD electronics. The system is controlled by a standard PC computer.

Intelligent data management for real-time spacecraft monitoring

NASA Technical Reports Server (NTRS)

Schwuttke, Ursula M.; Gasser, Les; Abramson, Bruce

1992-01-01

Real-time AI systems have begun to address the challenge of restructuring problem solving to meet real-time constraints by making key trade-offs that pursue less than optimal strategies with minimal impact on system goals. Several approaches for adapting to dynamic changes in system operating conditions are known. However, simultaneously adapting system decision criteria in a principled way has been difficult. Towards this end, a general technique for dynamically making such trade-offs using a combination of decision theory and domain knowledge has been developed. Multi-attribute utility theory (MAUT), a decision theoretic approach for making one-time decisions is discussed and dynamic trade-off evaluation is described as a knowledge-based extension of MAUT that is suitable for highly dynamic real-time environments, and provides an example of dynamic trade-off evaluation applied to a specific data management trade-off in a real-world spacecraft monitoring application.

Development of a continuous radon concentration monitoring system in underground soil

NASA Astrophysics Data System (ADS)

Yamamoto, S.; Tarutani, K.; Yamasoto, K.; Iskandar, D.; Iida, T.

2001-06-01

A continuous radon (Rn-222) concentration monitoring system for use in underground soil was developed and tested. The system consists of a 19-mm-diameter, 1100-mm-long detector assembly and a microprocessor based data logger. A small volume chamber is installed at the tip of the detector assembly. A thin ZnS(Ag) scintillator film inside the chamber and a photomultiplier tube (PMT) detect alpha particles from radon and its daughters. When the system is in measurement, the detector part is buried into underground soil. An energy resolution of approximately 70% full width half maximum (FWHM) was obtained for 5.5 MeV alpha particles from Am-241. Both the rise time and fall time for the system were measured to be approximately 1-2 h. Temporal variations in underground radon concentration at different depths were investigated simultaneously using four sets of the developed system. The results confirmed that the developed system is useful for continuous measurement of radon concentration in underground soil.

Monitoring groundwater and river interaction along the Hanford reach of the Columbia River

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campbell, M.D.

1994-04-01

As an adjunct to efficient Hanford Site characterization and remediation of groundwater contamination, an automatic monitor network has been used to measure Columbia River and adjacent groundwater levels in several areas of the Hanford Site since 1991. Water levels, temperatures, and electrical conductivity measured by the automatic monitor network provided an initial database with which to calibrate models and from which to infer ground and river water interactions for site characterization and remediation activities. Measurements of the dynamic river/aquifer system have been simultaneous at 1-hr intervals, with a quality suitable for hydrologic modeling and for computer model calibration and testing.more » This report describes the equipment, procedures, and results from measurements done in 1993.« less

Adapting radio technology to LED feedback systems

NASA Astrophysics Data System (ADS)

Salsbury, Marc; Ashdown, Ian

2007-09-01

Superheterodyne techniques were originally developed for radio transmission and reception nearly a century ago. In this paper we explore the adaptation of this technology to the problem of simultaneously monitoring the intensities of multiple LED channels with a single photosensor. The use of superheterodyne techniques obviates the need for multiple photosensors filters and tristimulus color filters to monitor the relative intensities of red, green, and blue LEDs. In addition, they alleviate the problems of electrical and optical noise, as well as the influence of ambient illumination on the photosensors. They can also be used to advantage with phosphor-coated white light LEDs in solid state lighting systems. Taking a broader view, the use of such techniques demonstrates the value of looking outside the realm of conventional LED power and control technologies when designing solid state lighting systems.

Simultaneous measurement of skin potential and conductance in electrodermal response monitoring

NASA Astrophysics Data System (ADS)

Jabbari, A.; Johnsen, B.; Grimnes, S.; Martinsen, Ø. G.

2010-04-01

Measurement of electrodermal activity (EDA) has been an important tool in psychophysiological research. The emotional sweat activity is very sensitive to psychological stimuli or conditions. The changes are easily detected by means of electrical measurements and since the sweat ducts are predominantly resistive, a low-frequency conductance measurement is appropriate for measurement of skin conductance in electrodermal response. The main purpose of this study was to develop a measuring system where DC current was replaced by a small AC current in a system so the DC potential and AC conductance could be measured simultaneously at the same skin site. A small, battery operated, PDA based instrument has been developed. The preliminary results of this ongoing study show that there is additional information in the DC potential channel and that different stimuli seem to produce slightly different response patterns.

A biofilm microreactor system for simultaneous electrochemical and nuclear magnetic resonance techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Renslow, Ryan S.; Babauta, Jerome T.; Majors, Paul D.

2014-03-01

In order to fully understand electrochemically active biofilms and the limitations to their scale-up in industrial biofilm reactors, a complete picture of the microenvironments inside the biofilm is needed. Nuclear magnetic resonance (NMR) techniques are ideally suited for the study of biofilms and for probing their microenvironments because these techniques allow for non-invasive interrogation and in situ monitoring with high resolution. By combining NMR with simultaneous electrochemical techniques, it is possible to sustain and study live electrochemically active biofilms. Here, we introduce a novel biofilm microreactor system that allows for simultaneous electrochemical and NMR techniques (EC-NMR) at the microscale. Microreactorsmore » were designed with custom radiofrequency resonator coils, which allowed for NMR measurements of biofilms growing on polarized gold electrodes. For an example application of this system, we grew Geobacter sulfurreducens biofilms. NMR was used to investigate growth media flow velocities, which were compared to simulated laminar flow, and electron donor concentrations inside the biofilms. We use Monte Carlo error analysis to estimate standard deviations of the electron donor concentration measurements within the biofilm. The EC-NMR biofilm microreactor system can ultimately be used to correlate extracellular electron transfer rates with metabolic reactions and explore extracellular electron transfer mechanisms.« less

Detection, Identification, Location, and Remote Sensing Using SAW RFID Sensor Tags

NASA Technical Reports Server (NTRS)

Barton, Richard J.; Kennedy, Timothy F.; Williams, Robert M.; Fink, Patrick W.; Ngo, Phong H.

2009-01-01

The Electromagnetic Systems Branch (EV4) of the Avionic Systems Division at NASA Johnson Space Center in Houston, TX is studying the utility of surface acoustic wave (SAW) radiofrequency identification (RFID) tags for multiple wireless applications including detection, identification, tracking, and remote sensing of objects on the lunar surface, monitoring of environmental test facilities, structural shape and health monitoring, and nondestructive test and evaluation of assets. For all of these applications, it is anticipated that the system utilized to interrogate the SAW RFID tags may need to operate at fairly long range and in the presence of considerable multipath and multiple-access interference. Towards that end, EV4 is developing a prototype SAW RFID wireless interrogation system for use in such environments called the Passive Adaptive RFID Sensor Equipment (PARSED) system. The system utilizes a digitally beam-formed planar receiving antenna array to extend range and provide direction-of-arrival information coupled with an approximate maximum-likelihood signal processing algorithm to provide near-optimal estimation of both range and temperature. The system is capable of forming a large number of beams within the field of view and resolving the information from several tags within each beam. The combination of both spatial and waveform discrimination provides the capability to track and monitor telemetry from a large number of objects appearing simultaneously within the field of view of the receiving array. In this paper, we will consider the application of the PARSEQ system to the problem of simultaneous detection, identification, localization, and temperature estimation for multiple objects. We will summarize the overall design of the PARSEQ system and present a detailed description of the design and performance of the signal detection and estimation algorithms incorporated in the system. The system is currently configured only to measure temperature (jointly with range and tag ID), but future versions will be revised to measure parameters other than temperature as SAW tags capable of interfacing with external sensors become available. It is anticipated that the estimation of arbitrary parameters measured using SAW-based sensors will be based on techniques very similar to the joint range and temperature estimation techniques described in this paper.

Oxygen sensing PLIM together with FLIM of intrinsic cellular fluorophores for metabolic mapping

NASA Astrophysics Data System (ADS)

Kalinina, Sviatlana; Schaefer, Patrick; Breymayer, Jasmin; Bisinger, Dominik; Chakrabortty, Sabyasachi; Rueck, Angelika

2018-02-01

Otical imaging techniques based on time correlated single photon counting (TCSPC) has found wide applications in medicine and biology. Non-invasive and information-rich fluorescence lifetime imaging microscopy (FLIM) is successfully used for monitoring fluorescent intrinsic metabolic coenzymes as NAD(P)H (nicotinamide adenine dinucleotide (phosphate)) and FAD+ (flavin adenine dinucleotide) in living cells and tissues. The ratio between proteinbound and free coenzymes gives an information about the balance between oxidative phosphorylation and glycolysis in the cells. The changes of the ratio reflects major cellular disorders. A correlation exists between metabolic activity, redox ratio and fluorescence lifetime during stem cell differentiation, neurodegenerative diseases, and carcinogenesis. A multichannel FLIM detection system was designed for monitoring the redox state of NAD(P)H and FAD+ and other intrinsic fluorophores as protoporphyrin IX. In addition, the unique upgrade is useful to perform FLIM and PLIM (phosphorescence lifetime imaging microscopy) simultaneously. PLIM is a promising method to investigate oxygen sensing in biomedical samples. In detail, the oxygen-dependent quenching of phosphorescence of some compounds as transition metal complexes enables measuring of oxygen partial pressure (pO2). Using a two-channel FLIM/PLIM system we monitored intrinsic pO2 by PLIM simultaneously with NAD(P)H by FLIM providing complex metabolic and redox imaging of living cells. Physico-chemical properties of oxygen sensitive probes define certain parameters including their localisation. We present results of some ruthenium based complexes including those specifically bound to mitochondria.

Development of an On-animal Separation-based Sensor for Monitoring Drug Metabolism in Freely Roaming Sheep

PubMed Central

Scott, David E.; Willis, Sean D.; Gabbert, Seth; Johnson, Dave A.; Naylor, Erik; Janle, Elsa M.; Krichevsky, Janice E.; Lunte, Craig E.; Lunte, Susan M.

2015-01-01

The development of an on-animal separation-based sensor that can be employed for monitoring drug metabolism in a freely roaming sheep is described. The system consists of microdialysis sampling coupled directly to microchip electrophoresis with electrochemical detection (MD-ME-EC). Separations were accomplished using an all-glass chip with integrated platinum working and reference electrodes. Discrete samples from the microdialysis flow were introduced into the electrophoresis chip using a flow-gated injection approach. Electrochemical detection was accomplished in-channel using a two-electrode isolated potentiostat. Nitrite was separated by microchip electrophoresis using reverse polarity and a run buffer consisting of 50 mM phosphate at pH 7.4. The entire system was under telemetry control. The system was first tested with rats to monitor the production of nitrite following introduction of nitroglycerin into the subdermal tissue using a linear probe. The data acquired using the on-line MD-ME-EC system was compared to that obtained off-line analysis by liquid chromatography with electrochemical detection (LC-EC), using a second microdialysis probe implanted parallel to the first probe in the same animal. The MD-ME-EC device was then used on-animal to monitor the subdermal metabolism of nitroglycerin in sheep. The ultimate goal is to use this device to simultaneously monitor drug metabolism and behavior in a freely roaming animal. PMID:25697221

New Organ Allocation System for Combined Liver-Kidney Transplants and the Availability of Kidneys for Transplant to Patients with Stage 4-5 CKD.

PubMed

Asch, William S; Bia, Margaret J

2017-05-08

A new proposal has been created for establishing medical criteria for organ allocation in recipients receiving simultaneous liver-kidney transplants. In this article, we describe the new policy, elaborate on the points of greatest controversy, and offer a perspective on the policy going forward. Although we applaud the fact that simultaneous liver-kidney transplant activity will now be monitored and appreciate the creation of medical criteria for allocation in simultaneous liver-kidney transplants, we argue that some of the criteria proposed, especially those for allocating a kidney to a liver recipient with AKI, are too liberal. We call on the nephrology community to follow the consequences of this new policy and push for a re-examination of the longstanding policy of allocating kidneys to multiorgan transplant recipients before all other candidates. The charge to protect our system of equitable organ allocation is very challenging, but it is a challenge that we must embrace. Copyright © 2017 by the American Society of Nephrology.

Simultaneous atmospheric nitrous oxide, methane and water vapor detection with a single continuous wave quantum cascade laser.

PubMed

Cao, Yingchun; Sanchez, Nancy P; Jiang, Wenzhe; Griffin, Robert J; Xie, Feng; Hughes, Lawrence C; Zah, Chung-en; Tittel, Frank K

2015-02-09

A continuous wave (CW) quantum cascade laser (QCL) based absorption sensor system was demonstrated and developed for simultaneous detection of atmospheric nitrous oxide (N(2)O), methane (CH(4)), and water vapor (H(2)O). A 7.73-µm CW QCL with its wavelength scanned over a spectral range of 1296.9-1297.6 cm(-1) was used to simultaneously target three neighboring strong absorption lines, N(2)O at 1297.05 cm(-1), CH(4) at 1297.486 cm(-1), and H(2)O at 1297.184 cm(-1). An astigmatic multipass Herriott cell with a 76-m path length was utilized for laser based gas absorption spectroscopy at an optimum pressure of 100 Torr. Wavelength modulation and second harmonic detection was employed for data processing. Minimum detection limits (MDLs) of 1.7 ppb for N(2)O, 8.5 ppb for CH(4), and 11 ppm for H(2)O were achieved with a 2-s integration time for individual gas detection. This single QCL based multi-gas detection system possesses applications in environmental monitoring and breath analysis.

Armored Combat Vehicles Science and Technology Plan

DTIC Science & Technology

1982-11-01

APPLICATION OF SENSORS Investigate the seismic, acoustic, and electromagnetic signatures of military and intruder -type targets and the theoretical aspects...a prototype sampling system which has the capability to monitor ambieut air both outside and inside vehicles and provide an early warning to the crew...and through various processing modules provide automated functions for simultaneous tracking of targets and automitic recognition, 74 f’," SENSING

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis

PubMed Central

Nyein, Hnin Yin Yin; Challa, Samyuktha; Chen, Kevin; Peck, Austin; Fahad, Hossain M.; Ota, Hiroki; Shiraki, Hiroshi; Kiriya, Daisuke; Lien, Der-Hsien; Brooks, George A.; Davis, Ronald W.; Javey, Ali

2016-01-01

Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health1–12. Sampling human sweat, which is rich in physiological information13, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state14–18. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications. PMID:26819044

Patient Monitoring

NASA Technical Reports Server (NTRS)

1978-01-01

In photo above, the electrocardiogram of a hospitalized patient is being transmitted by telemetry. Widely employed in space operations, telemetry is a process wherein instrument data is converted to electrical signals and sent to a receiver where the signals are reconverted to usable information. In this instance, heart readings are picked up by the electrode attached to the patient's body and delivered by wire to the small box shown, which is a telemetry transmitter. The signals are relayed wirelessly to the console in the background, which converts them to EKG data. The data is displayed visually and recorded on a printout; at the same time, it is transmitted to a central control station (upper photo) where a nurse can monitor the condition of several patients simultaneously. The Patient Monitoring System was developed by SCI Systems, Inc., Huntsville, Alabama, in conjunction with Abbott Medical Electronics, Houston, Texas. In developing the system, SCI drew upon its extensive experience as a NASA contractor. The company applied telemetry technology developed for the Saturn launch vehicle and the Apollo spacecraft; instrumentation technology developed for heart, blood pressure and sleep monitoring of astronauts aboard NASA's Skylab long duration space station; and communications technology developed for the Space Shuttle.

Single-well monitoring of protein-protein interaction and phosphorylation-dephosphorylation events.

PubMed

Arcand, Mathieu; Roby, Philippe; Bossé, Roger; Lipari, Francesco; Padrós, Jaime; Beaudet, Lucille; Marcil, Alexandre; Dahan, Sophie

2010-04-20

We combined oxygen channeling assays with two distinct chemiluminescent beads to detect simultaneously protein phosphorylation and interaction events that are usually monitored separately. This novel method was tested in the ERK1/2 MAP kinase pathway. It was first used to directly monitor dissociation of MAP kinase ERK2 from MEK1 upon phosphorylation and to evaluate MAP kinase phosphatase (MKP) selectivity and mechanism of action. In addition, MEK1 and ERK2 were probed with an ATP competitor and an allosteric MEK1 inhibitor, which generated distinct phosphorylation-interaction patterns. Simultaneous monitoring of protein-protein interactions and substrate phosphorylation can provide significant mechanistic insight into enzyme activity and small molecule action.

Multi-channel electrical impedance tomography for regional tissue hydration monitoring.

PubMed

Chen, Xiaohui; Kao, Tzu-Jen; Ashe, Jeffrey M; Boverman, Gregory; Sabatini, James E; Davenport, David M

2014-06-01

Poor assessment of hydration status during hemodialysis can lead to under- or over-hydration in patients with consequences of increased morbidity and mortality. In current practice, fluid management is largely based on clinical assessments to estimate dry weight (normal hydration body weight). However, hemodialysis patients usually have co-morbidities that can make the signs of fluid status ambiguous. Therefore, achieving normal hydration status remains a major challenge for hemodialysis therapy. Electrical impedance technology has emerged as a promising method for hydration monitoring due to its non-invasive nature, low cost and ease-of-use. Conventional electrical impedance-based hydration monitoring systems employ single-channel current excitation (either 2-electrode or 4-electrode methods) to perturb and extract averaged impedance from bulk tissue and use generalized models from large populations to derive hydration estimates. In the present study, a prototype, single-frequency electrical impedance tomography (EIT) system with simultaneous multi-channel current excitation was used to enable regional hydration change detection. We demonstrated the capability to detect a difference in daily impedance change between left leg and right leg in healthy human subjects, who wore a compression sock only on one leg to reduce daily gravitational fluid accumulation. The impedance difference corresponded well with the difference of lower leg volume change between left leg and right leg measured by volumetry, which on average is ~35 ml, accounting for 0.7% of the lower leg volume. We have demonstrated the feasibility of using multi-channel EIT to extract hydration information in different tissue layers with minimal skin interference. Our simultaneous, multi-channel current excitation approach provides an effective method to separate electrode contact impedance and skin condition artifacts from hydration signals. The prototype system has the potential to be used in clinical settings for helping optimize patient fluid management during hemodialysis as well as for home monitoring of patients with congestive heart failure, chronic kidney disease, diabetes and other diseases with peripheral edema symptoms.

Initial Evaluation of Signal-Based Bayesian Monitoring

NASA Astrophysics Data System (ADS)

Moore, D.; Russell, S.

2016-12-01

We present SIGVISA (Signal-based Vertically Integrated Seismic Analysis), a next-generation system for global seismic monitoring through Bayesian inference on seismic signals. Traditional seismic monitoring systems rely on discrete detections produced by station processing software, discarding significant information present in the original recorded signal. By modeling signals directly, our forward model is able to incorporate a rich representation of the physics underlying the signal generation process, including source mechanisms, wave propagation, and station response. This allows inference in the model to recover the qualitative behavior of geophysical methods including waveform matching and double-differencing, all as part of a unified Bayesian monitoring system that simultaneously detects and locates events from a network of stations. We report results from an evaluation of SIGVISA monitoring the western United States for a two-week period following the magnitude 6.0 event in Wells, NV in February 2008. During this period, SIGVISA detects more than twice as many events as NETVISA, and three times as many as SEL3, while operating at the same precision; at lower precisions it detects up to five times as many events as SEL3. At the same time, signal-based monitoring reduces mean location errors by a factor of four relative to detection-based systems. We provide evidence that, given only IMS data, SIGVISA detects events that are missed by regional monitoring networks, indicating that our evaluations may even underestimate its performance. Finally, SIGVISA matches or exceeds the detection rates of existing systems for de novo events - events with no nearby historical seismicity - and detects through automated processing a number of such events missed even by the human analysts generating the LEB.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurley, D.F.; Whitehouse, J.M.

A dedicated low-flow groundwater sample collection system was designed for implementation in a post-closure ACL monitoring program at the Yaworski Lagoon NPL site in Canterbury, Connecticut. The system includes dedicated bladder pumps with intake ports located in the screened interval of the monitoring wells. This sampling technique was implemented in the spring of 1993. The system was designed to simultaneously obtain samples directly from the screened interval of nested wells in three distinct water bearing zones. Sample collection is begun upon stabilization of field parameters. Other than line volume, no prior purging of the well is required. It was foundmore » that dedicated low-flow sampling from the screened interval provides a method of representative sample collection without the bias of suspended solids introduced by traditional techniques of pumping and bailing. Analytical data indicate that measured chemical constituents are representative of groundwater migrating through the screened interval. Upon implementation of the low-flow monitoring system, analytical results exhibited a decrease in concentrations of some organic compounds and metals. The system has also proven to be a cost effective alternative to pumping and bailing which generate large volumes of purge water requiring containment and disposal.« less

Monitoring pulmonary function with superimposed pulmonary gas exchange curves from standard analyzers.

PubMed

Zar, Harvey A; Noe, Frances E; Szalados, James E; Goodrich, Michael D; Busby, Michael G

2002-01-01

A repetitive graphic display of the single breath pulmonary function can indicate changes in cardiac and pulmonary physiology brought on by clinical events. Parallel advances in computer technology and monitoring make real-time, single breath pulmonary function clinically practicable. We describe a system built from a commercially available airway gas monitor and off the shelf computer and data-acquisition hardware. Analog data for gas flow rate, O2, and CO2 concentrations are introduced into a computer through an analog-to-digital conversion board. Oxygen uptake (VO2) and carbon dioxide output (VCO2) are calculated for each breath. Inspired minus expired concentrations for O2 and CO2 are displayed simultaneously with the expired gas flow rate curve for each breath. Dead-space and alveolar ventilation are calculated for each breath and readily appreciated from the display. Graphs illustrating the function of the system are presented for the following clinical scenarios; upper airway obstruction, bronchospasm, bronchopleural fistula, pulmonary perfusion changes and inadequate oxygen delivery. This paper describes a real-time, single breath pulmonary monitoring system that displays three parameters graphed against time: expired flow rate, oxygen uptake and carbon dioxide production. This system allows for early and rapid recognition of treatable conditions that may lead to adverse events without any additional patient measurements or invasive procedures. Monitoring systems similar to the one described in this paper may lead to a higher level of patient safety without any additional patient risk.

A comparison of two ambulatory blood pressure monitors worn at the same time.

PubMed

Kallem, Radhakrishna R; Meyers, Kevin E C; Sawinski, Deirdre L; Townsend, Raymond R

2013-05-01

There are limited data in the literature comparing two simultaneously worn ambulatory blood pressure (BP) monitoring (ABPM) devices. The authors compared BPs from two monitors (Mobil-O-Graph [I.E.M., Stolberg, Germany] and Spacelabs 90207 [Spacelabs Medical, Issequah, WA]). In the nonrandomized component of the study, simultaneous 8-hour BP and heart rate data were measured by Mobil-O-Graph, consistently applied to the nondominant arm, and Spacelabs to the dominant arm on 12 untreated adults. Simultaneous 8-hour BP and heart data were obtained by the same monitors randomly assigned to a dominant or nondominant arm on 12 other untreated adults. Oscillometric BP profiles were obtained in the dominant and nondominant arms of the above 24 patients using an Accutorr (Datascope, Mahwah, NJ) device. The Spacelabs monitor recorded a 10.2-mm Hg higher systolic pressure in the nonrandomized (P=.0016) and a 7.9-mm Hg higher systolic pressure in the randomized studies (P=.00008) compared with the Mobil-O-Graph. The mean arterial pressures were 1 mm Hg to 2 mm Hg different between monitors in the two studies, and heart rates were nearly identical. Our observations, if confirmed in larger cohorts, support the concern that ABPM device manufacturers consider developing normative databases for their devices. ©2013 Wiley Periodicals, Inc.

Air Pollution Monitoring and Use of Nanotechnology Based Solid State Gas Sensors in Greater Cairo Area, Egypt

NASA Astrophysics Data System (ADS)

Ramadan, A. B. A.

Air pollution is a serious problem in thickly populated and industrialized areas in Egypt, especially in greater Cairo area. Economic growth and industrialization are proceeding at a rapid pace, accompanied by increasing emissions of air polluting sources. Furthermore, though the variety and quantities of polluting sources have increased dramatically, the development of a suitable method for monitoring the pollution causing sources has not followed at the same pace. Environmental impacts of air pollutants have impact on public health, vegetation, material deterioration etc. To prevent or minimize the damage caused by atmospheric pollution, suitable monitoring systems are urgently needed that can rapidly and reliably detect and quantify polluting sources for monitoring by regulating authorities in order to prevent further deterioration of the current pollution levels. Consequently, it is important that the current real-time air quality monitoring system, controlled by the Egyptian Environmental Affairs Agency (EEAA), should be adapted or extended to aid in alleviating this problem. Nanotechnology has been applied to several industrial and domestic fields, for example, applications for gas monitoring systems, gas leak detectors in factories, fire and toxic gas detectors, ventilation control, breath alcohol detectors, and the like. Here we report an application example of studying air quality monitoring based on nanotechnology `solid state gas sensors'. So as to carry out air pollution monitoring over an extensive area, a combination of ground measurements through inexpensive sensors and wireless GIS will be used for this purpose. This portable device, comprising solid state gas sensors integrated to a Personal Digital Assistant (PDA) linked through Bluetooth communication tools and Global Positioning System (GPS), will allow rapid dissemination of information on pollution levels at multiple sites simultaneously.

Deformation Monitoring of Waste-Rock-Backfilled Mining Gob for Ground Control

PubMed Central

Zhao, Tongbin; Zhang, Yubao; Zhang, Zhenyu; Li, Zhanhai; Ma, Shuqi

2017-01-01

Backfill mining is an effective option to mitigate ground subsidence, especially for mining under surface infrastructure, such as buildings, dams, rivers and railways. To evaluate its performance, continual long-term field monitoring of the deformation of backfilled gob is important to satisfy strict public scrutiny. Based on industrial Ethernet, a real-time monitoring system was established to monitor the deformation of waste-rock-backfilled gob at −700 m depth in the Tangshan coal mine, Hebei Province, China. The designed deformation sensors, based on a resistance transducer mechanism, were placed vertically between the roof and floor. Stress sensors were installed above square steel plates that were anchored to the floor strata. Meanwhile, data cables were protected by steel tubes in case of damage. The developed system continually harvested field data for three months. The results show that industrial Ethernet technology can be reliably used for long-term data transmission in complicated underground mining conditions. The monitoring reveals that the roof subsidence of the backfilled gob area can be categorized into four phases. The bearing load of the backfill developed gradually and simultaneously with the deformation of the roof strata, and started to be almost invariable when the mining face passed 97 m. PMID:28475168

Deformation Monitoring of Waste-Rock-Backfilled Mining Gob for Ground Control.

PubMed

Zhao, Tongbin; Zhang, Yubao; Zhang, Zhenyu; Li, Zhanhai; Ma, Shuqi

2017-05-05

Backfill mining is an effective option to mitigate ground subsidence, especially for mining under surface infrastructure, such as buildings, dams, rivers and railways. To evaluate its performance, continual long-term field monitoring of the deformation of backfilled gob is important to satisfy strict public scrutiny. Based on industrial Ethernet, a real-time monitoring system was established to monitor the deformation of waste-rock-backfilled gob at -700 m depth in the Tangshan coal mine, Hebei Province, China. The designed deformation sensors, based on a resistance transducer mechanism, were placed vertically between the roof and floor. Stress sensors were installed above square steel plates that were anchored to the floor strata. Meanwhile, data cables were protected by steel tubes in case of damage. The developed system continually harvested field data for three months. The results show that industrial Ethernet technology can be reliably used for long-term data transmission in complicated underground mining conditions. The monitoring reveals that the roof subsidence of the backfilled gob area can be categorized into four phases. The bearing load of the backfill developed gradually and simultaneously with the deformation of the roof strata, and started to be almost invariable when the mining face passed 97 m.

Method for simultaneously making a plurality of acoustic signal sensor elements

NASA Technical Reports Server (NTRS)

Bryant, Timothy D. (Inventor); Wynkoop, Mark W. (Inventor); Holloway, Nancy M. H. (Inventor); Zuckerwar, Allan J. (Inventor)

2005-01-01

A fetal heart monitoring system preferably comprising a backing plate having a generally concave front surface and a generally convex back surface, and at least one sensor element attached to the concave front surface for acquiring acoustic fetal heart signals produced by a fetus within a body. The sensor element has a shape that conforms to the generally concave back surface of the backing plate. In one embodiment, the at least one sensor element comprises an inner sensor, and a plurality of outer sensors surrounding the inner sensor. The fetal heart monitoring system can further comprise a web belt, and a web belt guide movably attached to the web belt. The web belt guide being is to the convex back surface of the backing plate.

Method for Simultaneously Making a Plurality of Acoustic Signal Sensor Elements

NASA Technical Reports Server (NTRS)

Bryant, Timothy D.; Wynkoop, Mark W.; Holloway, Nancy M. H.; Zuckerwar, Allan J.

2005-01-01

A fetal heart monitoring system preferably comprising a backing plate having a generally concave front surface and a generally convex back surface, and at least one sensor element attached to the concave front surface for acquiring acoustic fetal heart signals produced by a fetus within a body. The sensor element has a shape that conforms to the generally concave back surface of the backing plate. In one embodiment, the at least one sensor element comprises an inner sensor, and a plurality of outer sensors surrounding the inner sensor. The fetal heart monitoring system can further comprise a web belt, and a web belt guide movably attached to the web belt. The web belt guide being is to the convex back surface of the backing plate.

A device for real-time live-cell microscopy during dynamic dual-modal mechanostimulation

NASA Astrophysics Data System (ADS)

Lorusso, D.; Nikolov, H. N.; Chmiel, T.; Beach, R. J.; Sims, S. M.; Dixon, S. J.; Holdsworth, D. W.

2017-03-01

Mechanotransduction - the process by which cells sense and respond to mechanical stimuli - is essential for several physiological processes including skeletal homeostasis. Mammalian cells are thought to be sensitive to different modes of mechanical stimuli, including vibration and fluid shear. To better understand the mechanisms underlying the early stages of mechanotransduction, we describe the development of devices for mechanostimulation (by vibration and fluid shear) of live cells that can be integrated with real-time optical microscopy. The integrated system can deliver up to 3 Pa of fluid shear simultaneous with high-frequency sinusoidal vibrations up to 1 g. Stimuli can be applied simultaneously or independently to cells during real-time microscopic imaging. A custom microfluidic chamber was prepared from polydimethylsiloxane on a glass-bottom cell culture dish. Fluid flow was applied with a syringe pump to induce shear stress. This device is compatible with a custom-designed motion control vibration system. A voice coil actuates the system that is suspended on linear air bushings. Accelerations produced by the system were monitored with an on-board accelerometer. Displacement was validated optically using particle tracking digital high-speed imaging (1200 frames per second). During operation at nominally 45 Hz and 0.3 g, displacements were observed to be within 3.56% of the expected value. MC3T3-E1 osteoblast like cells were seeded into the microfluidic device and loaded with the calcium sensitive fluorescent probe fura-2, then mounted onto the dual-modal mechanostimulation platform. Cells were then imaged and monitored for fluorescence emission. In summary, we have developed a system to deliver physiologically relevant vibrations and fluid shear to live cells during real-time imaging and photometry. Monitoring the behavior of live cells loaded with appropriate fluorescent probes will enable characterization of the signals activated during the initial stages of mechanotransduction.

Comparative analysis of radioecological monitoring dosimeters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sobolev, A.I.; Pol`skii, O.G.; Shanin, O.B.

1995-03-01

This paper describes comparative estimates of radiation doses measured by two types of thermoluminescence dosimeters and two types of background radiation radiometers. The dosimetry systems were tested by simultaneously recording background radiation and standard radiation sources at a radioactive waste storage facility. Statistical analysis of the measurement results is summarized. The maximum recorded exposure dose rate for the experiment was 19 microrads per hour. The DTK-2 dosimeter overestimated dose rates by 6 to 43% and the DTU-2 dosimeter underestimated dose rates by 7 to 21%. Both devices are recommended for radioecological monitoring in populated areas. 4 refs., 3 figs., 5more » tabs.« less

Application of MODIS-Derived Active Fire Radiative Energy to Fire Disaster and Smoke Pollution Monitoring

NASA Technical Reports Server (NTRS)

Ichoku, Charles; Kaufman, Yoram J.; Hao, Wei Min; Habib, Shahid

2004-01-01

The radiative energy emitted by large fires and the corresponding smoke aerosol loading are simultaneously measured from the MODIS sensor from both the Terra and Aqua satellites. Quantitative relationships between the rates of emission of fire radiative energy and smoke are being developed for different fire-prone regions of the globe. Preliminary results are presented. When fully developed, the system will enable the use of MODIS direct broadcast fire data for near real-time monitoring of fire strength and smoke emission as well as forecasting of fire progression and smoke dispersion, several hours to a few days in advance.

Acoustical Detection Of Leakage In A Combustor

NASA Technical Reports Server (NTRS)

Puster, Richard L.; Petty, Jeffrey L.

1993-01-01

Abnormal combustion excites characteristic standing wave. Acoustical leak-detection system gives early warning of failure, enabling operating personnel to stop combustion process and repair spray bar before leak grows large enough to cause damage. Applicable to engines, gas turbines, furnaces, and other machines in which acoustic emissions at known frequencies signify onset of damage. Bearings in rotating machines monitored for emergence of characteristic frequencies shown in previous tests associated with incipient failure. Also possible to monitor for signs of trouble at multiple frequencies by feeding output of transducer simultaneously to multiple band-pass filters and associated circuitry, including separate trigger circuit set to appropriate level for each frequency.

CONTROL SYSTEM FOR ISOTOPE SEPARATING APPARATUS

DOEpatents

Barnes, S.W.

1960-01-26

A method is described for controlling the position of the ion beams in a calutron used for isotope separation. The U/sup 238/ beams is centered over the U/sup 235/ receiving pocket, the operator monitoring the beam until a maximum reading is achieved on the meter connected to that pocket. Then both beams are simultaneously shifted by a preselected amount to move the U/sup 235/ beam over the U/sup 235/ pocket. A slotted door is placed over the entrance to that pocket during the U/sup 238/ beam centering to reduce the contamination to the pocket, while allowing enough beam to pass for monitoring purposes.

Developing the human-computer interface for Space Station Freedom

NASA Technical Reports Server (NTRS)

Holden, Kritina L.

1991-01-01

For the past two years, the Human-Computer Interaction Laboratory (HCIL) at the Johnson Space Center has been involved in prototyping and prototype reviews of in support of the definition phase of the Space Station Freedom program. On the Space Station, crew members will be interacting with multi-monitor workstations where interaction with several displays at one time will be common. The HCIL has conducted several experiments to begin to address design issues for this complex system. Experiments have dealt with design of ON/OFF indicators, the movement of the cursor across multiple monitors, and the importance of various windowing capabilities for users performing multiple tasks simultaneously.

Live single cell functional phenotyping in droplet nano-liter reactors

NASA Astrophysics Data System (ADS)

Konry, Tania; Golberg, Alexander; Yarmush, Martin

2013-11-01

While single cell heterogeneity is present in all biological systems, most studies cannot address it due to technical limitations. Here we describe a nano-liter droplet microfluidic-based approach for stimulation and monitoring of surfaceand secreted markers of live single immune dendritic cells (DCs) as well as monitoring the live T cell/DC interaction. This nano-liter in vivo simulating microenvironment allows delivering various stimuli reagents to each cell and appropriate gas exchanges which are necessary to ensure functionality and viability of encapsulated cells. Labeling bioassay and microsphere sensors were integrated into nano-liter reaction volume of the droplet to monitor live single cell surface markers and secretion analysis in the time-dependent fashion. Thus live cell stimulation, secretion and surface monitoring can be obtained simultaneously in distinct microenvironment, which previously was possible using complicated and multi-step in vitro and in vivo live-cell microscopy, together with immunological studies of the outcome secretion of cellular function.

Long-term synchronized electrophysiological and behavioral wireless monitoring of freely moving animals

PubMed Central

Grand, Laszlo; Ftomov, Sergiu; Timofeev, Igor

2012-01-01

Parallel electrophysiological recording and behavioral monitoring of freely moving animals is essential for a better understanding of the neural mechanisms underlying behavior. In this paper we describe a novel wireless recording technique, which is capable of synchronously recording in vivo multichannel electrophysiological (LFP, MUA, EOG, EMG) and activity data (accelerometer, video) from freely moving cats. The method is based on the integration of commercially available components into a simple monitoring system and is complete with accelerometers and the needed signal processing tools. LFP activities of freely moving group-housed cats were recorded from multiple intracortical areas and from the hippocampus. EMG, EOG, accelerometer and video were simultaneously acquired with LFP activities 24-h a day for 3 months. These recordings confirm the possibility of using our wireless method for 24-h long-term monitoring of neurophysiological and behavioral data of freely moving experimental animals such as cats, ferrets, rabbits and other large animals. PMID:23099345

Monitoring thioredoxin redox with a genetically encoded red fluorescent biosensor.

PubMed

Fan, Yichong; Makar, Merna; Wang, Michael X; Ai, Hui-Wang

2017-09-01

Thioredoxin (Trx) is one of the two major thiol antioxidants, playing essential roles in redox homeostasis and signaling. Despite its importance, there is a lack of methods for monitoring Trx redox dynamics in live cells, hindering a better understanding of physiological and pathological roles of the Trx redox system. In this work, we developed the first genetically encoded fluorescent biosensor for Trx redox by engineering a redox relay between the active-site cysteines of human Trx1 and rxRFP1, a redox-sensitive red fluorescent protein. We used the resultant biosensor-TrxRFP1-to selectively monitor perturbations of Trx redox in various mammalian cell lines. We subcellularly localized TrxRFP1 to image compartmentalized Trx redox changes. We further combined TrxRFP1 with a green fluorescent Grx1-roGFP2 biosensor to simultaneously monitor Trx and glutathione redox dynamics in live cells in response to chemical and physiologically relevant stimuli.

Implementation of a real-time multi-channel gateway server in ubiquitous integrated biotelemetry system for emergency care (UIBSEC).

PubMed

Cheon, Gyeongwoo; Shin, Il Hyung; Jung, Min Yang; Kim, Hee Chan

2009-01-01

We developed a gateway server to support various types of bio-signal monitoring devices for ubiquitous emergency healthcare in a reliable, effective, and scalable way. The server provides multiple channels supporting real-time N-to-N client connections. We applied our system to four types of health monitoring devices including a 12-channel electrocardiograph (ECG), oxygen saturation (SpO(2)), and medical imaging devices (a ultrasonograph and a digital skin microscope). Different types of telecommunication networks were tested: WIBRO, CDMA, wireless LAN, and wired internet. We measured the performance of our system in terms of the transmission rate and the number of simultaneous connections. The results show that the proposed network communication strategy can be successfully applied to the ubiquitous emergency healthcare service by providing a fast rate enough for real-time video transmission and multiple connections among patients and medical personnel.

Simultaneous Time, Wavelength and Intensity Measurement of Optical Memory Subsystems

DTIC Science & Technology

1998-07-01

SIMULTANEOUS TIME, WAVELENGTH AND INTENSITY MEASUREMENT PE - 61102F OF OPTICAL MEMORY SUBSYSTEMS PR - 2300 6. AUTHOR( S ) TA - 06 WU -03 Joseph Osman and...Rebecca Bussjager 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER AFRL/SNDP25 letnic AFRL-SN-RS-TR- 1998...12025 Electronic Pky Rome, NY 13441-4515 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSORING/MONITORING AGENCY REPORT NUMBER

Development of an advanced radioactive airborne particle monitoring system for use in early warning networks.

PubMed

Baeza, A; Corbacho, J A; Caballero, J M; Ontalba, M A; Vasco, J; Valencia, D

2017-09-25

Automatic real-time warning networks are essential for the almost immediate detection of anomalous levels of radioactivity in the environment. In the case of Extremadura region (SW Spain), a radiological network (RARE) has been operational in the vicinity of the Almaraz nuclear power plant and in other areas farther away since 1992. There are ten air monitoring stations equipped with Geiger-Müller counters in order to evaluate the external ambient gamma dose rate. Four of these stations have a commercial system that provides estimates of the total artificial alpha and beta activity concentrations in aerosols, and of the 131 I activity (gaseous fraction). Despite experience having demonstrated the benefits and robustness of these commercial systems, important improvements have been made to one of these air monitoring systems. In this paper, the analytical and maintenance shortcomings of the original commercial air monitoring system are described first; the new custom-designed advanced air monitoring system is then presented. This system is based mainly on the incorporation of gamma spectrometry using two scintillation detectors, one of NaI:Tl and the other of LaBr 3 :Ce, and compact multichannel analysers. Next, a comparison made of the results provided by the two systems operating simultaneously at the same location for three months shows the advantages of the new advanced air monitoring system. As a result, the gamma spectrometry analysis allows passing from global alpha and beta activity determinations due to artificial radionuclides in aerosols, and the inaccurate measurement of the gaseous 131 I activity concentration, to the possibility of identifying a large number of radionuclides and quantifying each of their activity concentrations. Moreover, the new station's dual capacity is designed to work in early warning monitoring mode and surveillance monitoring mode. This is based on custom developed software that includes an intelligent system to issue the necessary warnings when radiological anomalies or technical problems are identified. Implicitly, for the construction of the advanced station, substantial mechanical and electronic developments have been required. They have essentially consisted of integrating a new replacement device, whose operation has reduced the maintenance tasks.

Simultaneous laser-induced fluorescence and scattering detection of individual particles separated by capillary electrophoresis.

PubMed

Andreyev, Dmitry; Arriaga, Edgar A

2007-07-15

This technical note describes a detector capable of simultaneously monitoring scattering and fluorescence signals of individual particles separated by capillary electrophoresis. Due to its nonselective nature, scattering alone is not sufficient to identify analyte particles. However, when the analyte particles are fluorescent, the detector described here is able to identify simultaneously occurring scattering and fluorescent signals, even when contaminating particles (i.e., nonfluorescent) are present. Both fluorescent polystyrene particles and 10-nonyl acridine orange (NAO)-labeled mitochondria were used as models. Fluorescence versus scattering (FVS) plots made it possible to identify two types of particles and a contaminant in a mixture of polystyrene particles. We also analyzed NAO-labeled mitochondria before and after cryogenic storage; the mitochondria FVS plots changed with storage, which suggests that the detector reported here is suitable for monitoring subtle changes in mitochondrial morphology that would not be revealed by monitoring only fluorescence or scattering signals.

Wireless recording systems: from noninvasive EEG-NIRS to invasive EEG devices.

PubMed

Sawan, Mohamad; Salam, Muhammad T; Le Lan, Jérôme; Kassab, Amal; Gelinas, Sébastien; Vannasing, Phetsamone; Lesage, Frédéric; Lassonde, Maryse; Nguyen, Dang K

2013-04-01

In this paper, we present the design and implementation of a wireless wearable electronic system dedicated to remote data recording for brain monitoring. The reported wireless recording system is used for a) simultaneous near-infrared spectrometry (NIRS) and scalp electro-encephalography (EEG) for noninvasive monitoring and b) intracerebral EEG (icEEG) for invasive monitoring. Bluetooth and dual radio links were introduced for these recordings. The Bluetooth-based device was embedded in a noninvasive multichannel EEG-NIRS system for easy portability and long-term monitoring. On the other hand, the 32-channel implantable recording device offers 24-bit resolution, tunable features, and a sampling frequency up to 2 kHz per channel. The analog front-end preamplifier presents low input-referred noise of 5 μ VRMS and a signal-to-noise ratio of 112 dB. The communication link is implemented using a dual-band radio frequency transceiver offering a half-duplex 800 kb/s data rate, 16.5 mW power consumption and less than 10(-10) post-correction Bit-Error Rate (BER). The designed system can be accessed and controlled by a computer with a user-friendly graphical interface. The proposed wireless implantable recording device was tested in vitro using real icEEG signals from two patients with refractory epilepsy. The wirelessly recorded signals were compared to the original signals recorded using wired-connection, and measured normalized root-mean square deviation was under 2%.

D-Shaped Polarization Maintaining Fiber Sensor for Strain and Temperature Monitoring.

PubMed

Qazi, Hummad Habib; Mohammad, Abu Bakar; Ahmad, Harith; Zulkifli, Mohd Zamani

2016-09-15

A D-shaped polarization-maintaining fiber (PMF) as fiber optic sensor for the simultaneous monitoring of strain and the surrounding temperature is presented. A mechanical end and edge polishing system with aluminum oxide polishing film is utilized to perform sequential polishing on one side (lengthwise) of the PMF in order to fabricate a D-shaped cross-section. Experimental results show that the proposed sensor has high sensitivity of 46 pm/µε and 130 pm/°C for strain and temperature, respectively, which is significantly higher than other recently reported work (mainly from 2013) related to fiber optic sensors. The easy fabrication method, high sensitivity, and good linearity make this sensing device applicable in various applications such as health monitoring and spatial analysis of engineering structures.

D-Shaped Polarization Maintaining Fiber Sensor for Strain and Temperature Monitoring

PubMed Central

Qazi, Hummad Habib; Mohammad, Abu Bakar; Ahmad, Harith; Zulkifli, Mohd Zamani

2016-01-01

A D-shaped polarization-maintaining fiber (PMF) as fiber optic sensor for the simultaneous monitoring of strain and the surrounding temperature is presented. A mechanical end and edge polishing system with aluminum oxide polishing film is utilized to perform sequential polishing on one side (lengthwise) of the PMF in order to fabricate a D-shaped cross-section. Experimental results show that the proposed sensor has high sensitivity of 46 pm/µε and 130 pm/°C for strain and temperature, respectively, which is significantly higher than other recently reported work (mainly from 2013) related to fiber optic sensors. The easy fabrication method, high sensitivity, and good linearity make this sensing device applicable in various applications such as health monitoring and spatial analysis of engineering structures. PMID:27649195

Get smart, go optical: example uses of optical fibre sensing technology for production optimisation and subsea asset monitoring

NASA Astrophysics Data System (ADS)

Staveley, Chris

2014-06-01

With the growth in deep-water oil and gas production, condition monitoring of high-value subsea assets to give early warning of developing problems is vital. Offshore operators can then transport and deploy spare parts before a failure occurs, so minimizing equipment down-time, and the significant costs associated with unscheduled maintenance. Results are presented from a suite of tests in which multiple elements of a subsea twin-screw pump and associated electric motor were monitored using a fibre optic sensing system based on fibre Bragg gratings (FBG) that simultaneously measured dynamic strain on the main rotor bearings, pressure and temperature of the lubricating oil, distributed temperature through the motor stator windings and vibration of the pump and motor housings.

FRAM telescope - monitoring of atmospheric extinction and variable star photometry

NASA Astrophysics Data System (ADS)

Jurysek, J.; Honkova, K.; Masek, M.

2015-02-01

The FRAM (F/(Ph)otometric Robotic Atmospheric Monitor) telescope is a part of the Pierre Auger Observatory (PAO) located near town Malargüe in Argentina. The main task of the FRAM telescope is the continuous night - time monitoring of the atmospheric extinction and its wavelength dependence. The current methodology of the measurement of a atmospheric extinction and for instrumentation properties also allows simultaneous observation of other interesting astronomical targets. The current observations of the FRAM telescope are focused on the photometry of eclipsing binaries, positional refinement of minor bodies of the Solar system and observations of optical counterparts of gamma ray bursts. In this contribution, we briefly describe the main purpose of the FRAM telescope for the PAO and we also present its current astrono mical observing program.

Usefulness of simultaneous and sequential monitoring of glucose level and electrocardiogram in monkeys treated with gatifloxacin under conscious and nonrestricted conditions.

PubMed

Yoshimatsu, Yu; Ishizaka, Tomomichi; Chiba, Katsuyoshi; Mori, Kazuhiko

2018-05-10

Drug-induced cardiac electrophysiological abnormalities accompanied by hypoglycemia or hyperglycemia increase the risk for life-threatening arrhythmia. To assess the drug-induced cardiotoxic potential associated with extraordinary blood glucose (GLU) levels, the effect of gatifloxacin (GFLX) which was frequently associated with GLU abnormality and QT/QTc prolongations in the clinic on blood GLU and electrocardiogram (ECG) parameters was investigated in cynomolgus monkeys (n=4) given GFLX orally in an ascending dose regimen (10, 30, 60 and 100 mg/kg). Simultaneous and sequential GLU and ECG monitoring with a continuous GLU monitoring system and Holter ECG, respectively, were conducted for 24 h under free-moving conditions. Consequently, GFLX at 30 and 60 mg/kg dose-dependently induced a transient decrease in GLU without any ECG abnormality 2-4 h postdose. Highest dose of 100 mg/kg caused severe hypoglycemia with a mean GLU of <30 mg/dL, accompanied by remarkable QT/QTc prolongations by 20-30% in all animals. In contrast, hyperglycemia without QT/QTc prolongations was noted 24 h after dosing in one animal. A close correlation between GLU and QTc values was observed in animals treated with 100 mg/kg, suggesting that GFLX-induced hypoglycemia enhanced QT/QTc prolongations. Furthermore, the 24-h sequential GLU monitoring data clearly distinguished between GFLX-induced GLU abnormality and physiological GLU changes influenced by feeding throughout the day. In conclusion, the combined assessment of continuous GLU and ECG monitoring is valuable in predicting the drug-induced cardio-electrophysiological risk associated with both GLU and ECG abnormalities.

Early Detection of Infection in Pigs through an Online Monitoring System.

PubMed

Martínez-Avilés, M; Fernández-Carrión, E; López García-Baones, J M; Sánchez-Vizcaíno, J M

2017-04-01

Late detection of emergency diseases causes significant economic losses for pig producers and governments. As the first signs of animal infection are usually fever and reduced motion that lead to reduced consumption of water and feed, we developed a novel smart system to monitor body temperature and motion in real time, facilitating the early detection of infectious diseases. In this study, carried out within the framework of the European Union research project Rapidia Field, we tested the smart system on 10 pigs experimentally infected with two doses of an attenuated strain of African swine fever. Biosensors and an accelerometer embedded in an eartag captured data before and after infection, and video cameras were used to monitor the animals 24 h per day. The results showed that in 8 of 9 cases, the monitoring system detected infection onset as an increase in body temperature and decrease in movement before or simultaneously with fever detection based on rectal temperature measurement, observation of clinical signs, the decrease in water consumption or positive qPCR detection of virus. In addition, this decrease in movement was reliably detected using automatic analysis of video images therefore providing an inexpensive alternative to direct motion measurement. The system can be set up to alert staff when high fever, reduced motion or both are detected in one or more animals. This system may be useful for monitoring sentinel herds in real time, considerably reducing the financial and logistical costs of periodic sampling and increasing the chances of early detection of infection. © 2015 Blackwell Verlag GmbH.

Calcium neuroimaging in behaving zebrafish larvae using a turn-key light field camera

NASA Astrophysics Data System (ADS)

Cruz Perez, Carlos; Lauri, Antonella; Symvoulidis, Panagiotis; Cappetta, Michele; Erdmann, Arne; Westmeyer, Gil Gregor

2015-09-01

Reconstructing a three-dimensional scene from multiple simultaneously acquired perspectives (the light field) is an elegant scanless imaging concept that can exceed the temporal resolution of currently available scanning-based imaging methods for capturing fast cellular processes. We tested the performance of commercially available light field cameras on a fluorescent microscopy setup for monitoring calcium activity in the brain of awake and behaving reporter zebrafish larvae. The plenoptic imaging system could volumetrically resolve diverse neuronal response profiles throughout the zebrafish brain upon stimulation with an aversive odorant. Behavioral responses of the reporter fish could be captured simultaneously together with depth-resolved neuronal activity. Overall, our assessment showed that with some optimizations for fluorescence microscopy applications, commercial light field cameras have the potential of becoming an attractive alternative to custom-built systems to accelerate molecular imaging research on cellular dynamics.

Calcium neuroimaging in behaving zebrafish larvae using a turn-key light field camera.

PubMed

Perez, Carlos Cruz; Lauri, Antonella; Symvoulidis, Panagiotis; Cappetta, Michele; Erdmann, Arne; Westmeyer, Gil Gregor

2015-09-01

Reconstructing a three-dimensional scene from multiple simultaneously acquired perspectives (the light field) is an elegant scanless imaging concept that can exceed the temporal resolution of currently available scanning-based imaging methods for capturing fast cellular processes. We tested the performance of commercially available light field cameras on a fluorescent microscopy setup for monitoring calcium activity in the brain of awake and behaving reporter zebrafish larvae. The plenoptic imaging system could volumetrically resolve diverse neuronal response profiles throughout the zebrafish brain upon stimulation with an aversive odorant. Behavioral responses of the reporter fish could be captured simultaneously together with depth-resolved neuronal activity. Overall, our assessment showed that with some optimizations for fluorescence microscopy applications, commercial light field cameras have the potential of becoming an attractive alternative to custom-built systems to accelerate molecular imaging research on cellular dynamics.

A low-cost biomedical signal transceiver based on a Bluetooth wireless system.

PubMed

Fazel-Rezai, Reza; Pauls, Mark; Slawinski, David

2007-01-01

Most current wireless biomedical signal transceivers use range-limiting communication. This work presents a low-cost biomedical signal transceiver that uses Bluetooth wireless technology. The design is implemented in a modular form to be adaptable to different types of biomedical signals. The signal front end obtains and processes incoming signals, which are then transmitted via a microcontroller and wireless module. Near real-time receive software in LabVIEW was developed to demonstrate the system capability. The completed transmitter prototype successfully transmits ECG signals, and is able to simultaneously send multiple signals. The sampling rate of the transmitter is fast enough to send up to thirteen ECG signals simultaneously, with an error rate below 0.1% for transmission exceeding 65 meters. A low-cost wireless biomedical transceiver has many applications, such as real-time monitoring of patients with a known condition in non-clinical settings.

An Architecture for On-Line Measurement of the Tip Clearance and Time of Arrival of a Bladed Disk of an Aircraft Engine

PubMed Central

Solís, Alejandro; Aranguren, Gerardo; Zubia, Joseba

2017-01-01

Safety and performance of the turbo-engine in an aircraft is directly affected by the health of its blades. In recent years, several improvements to the sensors have taken place to monitor the blades in a non-intrusive way. The parameters that are usually measured are the distance between the blade tip and the casing, and the passing time at a given point. Simultaneously, several techniques have been developed that allow for the inference—from those parameters and under certain conditions—of the amplitude and frequency of the blade vibration. These measurements are carried out on engines set on a rig, before being installed in an airplane. In order to incorporate these methods during the regular operation of the engine, signal processing that allows for the monitoring of those parameters at all times should be developed. This article introduces an architecture, based on a trifurcated optic sensor and a hardware processor, that fulfills this need. The proposed architecture is scalable and allows several sensors to be simultaneously monitored at different points around a bladed disk. Furthermore, the results obtained by the electronic system will be compared with the results obtained by the validation of the optic sensor. PMID:28934105

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis

DOE PAGES

Gao, Wei; Emaminejad, Sam; Nyein, Hnin Yin Yin; ...

2016-01-27

We report that wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual’s state of health. Sampling human sweat, which is rich in physiological information13, could enable non-invasive monitoring. Previously reported sweat-based and other noninvasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state14–18. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanicallymore » flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Lastly, our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plasticbased sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.« less

An Architecture for On-Line Measurement of the Tip Clearance and Time of Arrival of a Bladed Disk of an Aircraft Engine.

PubMed

Gil-García, José Miguel; Solís, Alejandro; Aranguren, Gerardo; Zubia, Joseba

2017-09-21

Safety and performance of the turbo-engine in an aircraft is directly affected by the health of its blades. In recent years, several improvements to the sensors have taken place to monitor the blades in a non-intrusive way. The parameters that are usually measured are the distance between the blade tip and the casing, and the passing time at a given point. Simultaneously, several techniques have been developed that allow for the inference-from those parameters and under certain conditions-of the amplitude and frequency of the blade vibration. These measurements are carried out on engines set on a rig, before being installed in an airplane. In order to incorporate these methods during the regular operation of the engine, signal processing that allows for the monitoring of those parameters at all times should be developed. This article introduces an architecture, based on a trifurcated optic sensor and a hardware processor, that fulfills this need. The proposed architecture is scalable and allows several sensors to be simultaneously monitored at different points around a bladed disk. Furthermore, the results obtained by the electronic system will be compared with the results obtained by the validation of the optic sensor.

Simultaneous and accurate real-time monitoring of glucose and ethanol in alcoholic drinks, must, and biomass by a dual-amperometric biosensor.

PubMed

Mentana, Annalisa; Palermo, Carmen; Nardiello, Donatella; Quinto, Maurizio; Centonze, Diego

2013-01-09

In this work the optimization and application of a dual-amperometric biosensor for simultaneous monitoring of glucose and ethanol content, as quality markers in drinks and alcoholic fermentation media, are described. The biosensor is based on glucose oxidase (GOD) and alcohol oxidase (AOD) immobilized by co-cross-linking with bovine serum albumin (BSA) and glutaraldehyde (GLU) both onto a dual gold electrode, modified with a permselective overoxidized polypyrrole film (PPYox). Response, rejection of interferents, and stability of the dual biosensor were optimized in terms of PPYox thickness, BSA, and enzyme loading. The biosensor was integrated in a flow injection system coupled with an at-line microdialysis fiber as a sampling tool. Flow rates inside and outside the fiber were optimized in terms of linear responses (0.01-1 and 0.01-1.5 M) and sensitivities (27.6 ± 0.4 and 31.0 ± 0.6 μA·M(-1)·cm(-2)) for glucose and ethanol. Excellent anti-interference characteristics, the total absence of "cross-talk", and good response stability under operational conditions allowed application of the dual biosensor in accurate real-time monitoring (at least 15 samples/h) of alcoholic drinks, white grape must, and woody biomass.

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, Wei; Emaminejad, Sam; Nyein, Hnin Yin Yin

We report that wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual’s state of health. Sampling human sweat, which is rich in physiological information13, could enable non-invasive monitoring. Previously reported sweat-based and other noninvasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state14–18. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanicallymore » flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Lastly, our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plasticbased sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.« less

Sensing and Timekeeping Using A Light Trapping

DTIC Science & Technology

2017-06-01

bioassays, condensed matter physics, mate- rial science, biothermometry, bulk magnetometry for surveying, and hyper -polarized media for NMR. 1.3.2...obtained under continuous-wave (CW) microwave field excitation when a 3 mm diameter loop of 200 µm-diameter wire is placed 5 mm above the LTDW. An...frequency-locking technique was also developed to monitor both resonances simultaneously. A closed- loop system that locks to the center frequency of

JOVIAL/Ada Microprocessor Study.

DTIC Science & Technology

1982-04-01

Study Final Technical Report interesting feature of the nodes is that they provide multiple virtual terminals, so it is possible to monitor several...Terminal Interface Tasking Except ion Handling A more elaborate system could allow such features as spooling, background jobs or multiple users. To a large...Another editor feature is the buffer. Buffers may hold small amounts of text or entire text objects. They allow multiple files to be edited simultaneously

Estimating spatio-temporal dynamics of stream total phosphate concentration by soft computing techniques.

PubMed

Chang, Fi-John; Chen, Pin-An; Chang, Li-Chiu; Tsai, Yu-Hsuan

2016-08-15

This study attempts to model the spatio-temporal dynamics of total phosphate (TP) concentrations along a river for effective hydro-environmental management. We propose a systematical modeling scheme (SMS), which is an ingenious modeling process equipped with a dynamic neural network and three refined statistical methods, for reliably predicting the TP concentrations along a river simultaneously. Two different types of artificial neural network (BPNN-static neural network; NARX network-dynamic neural network) are constructed in modeling the dynamic system. The Dahan River in Taiwan is used as a study case, where ten-year seasonal water quality data collected at seven monitoring stations along the river are used for model training and validation. Results demonstrate that the NARX network can suitably capture the important dynamic features and remarkably outperforms the BPNN model, and the SMS can effectively identify key input factors, suitably overcome data scarcity, significantly increase model reliability, satisfactorily estimate site-specific TP concentration at seven monitoring stations simultaneously, and adequately reconstruct seasonal TP data into a monthly scale. The proposed SMS can reliably model the dynamic spatio-temporal water pollution variation in a river system for missing, hazardous or costly data of interest. Copyright © 2016 Elsevier B.V. All rights reserved.

Measurement accuracy of a stressed contact lens during its relaxation period

NASA Astrophysics Data System (ADS)

Compertore, David C.; Ignatovich, Filipp V.

2018-02-01

We examine the dioptric power and transmitted wavefront of a contact lens as it releases its handling stresses. Handling stresses are introduced as part of the contact lens loading process and are common across all contact lens measurement procedures and systems. The latest advances in vision correction require tighter quality control during the manufacturing of the contact lenses. The optical power of contact lenses is one of the critical characteristics for users. Power measurements are conducted in the hydrated state, where the lens is resting inside a solution-filled glass cuvette. In a typical approach, the contact lens must be subject to long settling times prior to any measurements. Alternatively, multiple measurements must be averaged. Apart from potential operator dependency of such approach, it is extremely time-consuming, and therefore it precludes higher rates of testing. Comprehensive knowledge about the settling process can be obtained by monitoring multiple parameters of the lens simultaneously. We have developed a system that combines co-aligned a Shack-Hartmann transmitted wavefront sensor and a time-domain low coherence interferometer to measure several optical and physical parameters (power, cylinder power, aberrations, center thickness, sagittal depth, and diameter) simultaneously. We monitor these parameters during the stress relaxation period and show correlations that can be used by manufacturers to devise methods for improved quality control procedures.

Monitoring the bending and twist of morphing structures

NASA Astrophysics Data System (ADS)

Smoker, J.; Baz, A.

2008-03-01

This paper presents the development of the theoretical basis for the design of sensor networks for determining the 2-dimensioal shape of morphing structures by monitoring simultaneously the bending and twist deflections. The proposed development is based on the non-linear theory of finite elements to extract the transverse linear and angular deflections of a plate-like structure. The sensors outputs are wirelessly transmitted to the command unit to simultaneously compute maps of the linear and angular deflections and maps of the strain distribution of the entire structure. The deflection and shape information are required to ascertain that the structure is properly deployed and that its surfaces are operating wrinkle-free. The strain map ensures that the structure is not loaded excessively to adversely affect its service life. The developed theoretical model is validated experimentally using a prototype of a variable cambered span morphing structure provided with a network of distributed sensors. The structure/sensor network system is tested under various static conditions to determine the response characteristics of the proposed sensor network as compared to other conventional sensor systems. The presented theoretical and experimental techniques can have a great impact on the safe deployment and effective operation of a wide variety of morphing and inflatable structures such as morphing aircraft, solar sails, inflatable wings, and large antennas.

Simultaneous measurements of ozone outside and inside cabins of two B-747 airliners and a Gates Learjet business jet

NASA Technical Reports Server (NTRS)

Perkins, P. J.; Briel, D.

1978-01-01

The average amount of ozone measured in the cabins of two B-747 airliners varied from 40 percent to 80 percent of the atmospheric concentrations without special ozone destruction systems. A charcoal filter in the cabin air inlet system of one B-747 reduced the ozone to about 5 percent of the atmospheric concentration. A Learjet 23 was also instrumented with monitors to measure simultaneously the atmospheric and ozone concentrations. Results indicate that a significant portion of the atmospheric ozone is not destroyed in the pressurization system and remains in the aircraft cabin of the Learjet. For the two cabin configurations tested, the ozone retentions were 63 and 41 percent of the atmospheric ozone concentrations. Ozone concentrations measured in the cabin near the conditioned-air outlets were reduced only slightly from atmospheric ozone concentrations. It is concluded that a constant difference between ozone concentrations inside and outside the cabin does not exist.

In vivo continuous and simultaneous monitoring of brain energy substrates with a multiplex amperometric enzyme-based biosensor device.

PubMed

Cordeiro, C A; de Vries, M G; Ngabi, W; Oomen, P E; Cremers, T I F H; Westerink, B H C

2015-05-15

Enzyme-based amperometric biosensors are widely used for monitoring key biomarkers. In experimental neuroscience there is a growing interest in in vivo continuous and simultaneous monitoring of metabolism-related biomarkers, like glucose, lactate and pyruvate. The use of multiplex biosensors will provide better understanding of brain energy metabolism and its role in neuropathologies such as diabetes, ischemia, and epilepsy. We have developed and characterized an implantable multiplex microbiosensor device (MBD) for simultaneous and continuous in vivo monitoring of glucose, lactate, and pyruvate. First, we developed and characterized amperometric microbiosensors for monitoring lactate and pyruvate. In vitro evaluation allowed us to choose the most suitable biosensors for incorporation into the MBD, along with glucose and background biosensors. Fully assembled MBDs were characterized in vitro. The calculated performance parameters (LOD, LR, LRS, IMAX and appKM) showed that the multiplex MBD was highly selective and sensitive (LRS≥100 nA/mM) for each analyte and within an adequate range for in vivo application. Finally, MBDs were implanted in the mPFC of anesthetized adult male Wistar rats for in vivo evaluation. Following an equilibration period, baseline brain levels of glucose (1.3±0.2 mM), lactate (1.5±0.4 mM) and pyruvate (0.3±0.1 mM) were established. Subsequently, the MBDs recorded the responses of the animals when submitted to hyperglycemic (40% glucose i.v.) and hypoglycemic (5 U/kg insulin i.v.) challenges. Afterwards, MBDs were recalibrated to convert electrochemical readings into accurate substrate concentrations and to assess biofouling. The presented MBD can monitor simultaneously multiple biomarkers in vivo. Copyright © 2014 Elsevier B.V. All rights reserved.

Vibration monitoring via nano-composite piezoelectric foam bushings

NASA Astrophysics Data System (ADS)

Bird, Evan T.; Merrell, A. Jake; Anderson, Brady K.; Newton, Cory N.; Rosquist, Parker G.; Fullwood, David T.; Bowden, Anton E.; Seeley, Matthew K.

2016-11-01

Most mechanical systems produce vibrations as an inherent side effect of operation. Though some vibrations are acceptable in operation, others can cause damage or signal a machine’s imminent failure. These vibrations would optimally be monitored in real-time, without human supervision to prevent failure and excessive wear in machinery. This paper explores a new alternative to currently-used machine-monitoring equipment, namely a piezoelectric foam sensor system. These sensors are made of a silicone-based foam embedded with nano- and micro-scale conductive particles. Upon impact, they emit an electric response that is directly correlated with impact energy, with no electrical power input. In the present work, we investigated their utility as self-sensing bushings on machinery. These sensors were found to accurately detect both the amplitude and frequency of typical machine vibrations. The bushings could potentially save time and money over other vibration sensing mechanisms, while simultaneously providing a potential control input that could be utilized for correcting vibrational imbalance.

Continuous ECG Monitoring in Patients With Acute Coronary Syndrome or Heart Failure: EASI Versus Gold Standard.

PubMed

Lancia, Loreto; Toccaceli, Andrea; Petrucci, Cristina; Romano, Silvio; Penco, Maria

2018-05-01

The purpose of the study was to compare the EASI system with the standard 12-lead surface electrocardiogram (ECG) for the accuracy in detecting the main electrocardiographic parameters (J point, PR, QT, and QRS) commonly monitored in patients with acute coronary syndromes or heart failure. In this observational comparative study, 253 patients who were consecutively admitted to the coronary care unit with acute coronary syndrome or heart failure were evaluated. In all patients, two complete 12-lead ECGs were acquired simultaneously. A total of 6,072 electrocardiographic leads were compared (3,036 standard and 3,036 EASI). No significant differences were found between the investigate parameters of the two measurement methods, either in patients with acute coronary syndrome or in those with heart failure. This study confirmed the accuracy of the EASI system in monitoring the main ECG parameters in patients admitted to the coronary care unit with acute coronary syndrome or heart failure.

Clinical evaluation of a simultaneous closed-loop anaesthesia control system for depth of anaesthesia and neuromuscular blockade*.

PubMed

Janda, M; Simanski, O; Bajorat, J; Pohl, B; Noeldge-Schomburg, G F E; Hofmockel, R

2011-12-01

We developed a closed-loop system to control the depth of anaesthesia and neuromuscular blockade using the bispectral index and the electromyogram simultaneously and evaluated the clinical performance of this combined system for general anaesthesia. Twenty-two adult patients were included in this study. Anaesthesia was induced by a continuous infusion of remifentanil at 0.4 μg.kg(-1) .min(-1) (induction dose) and then 0.25 μg.kg(-1) .min(-1) (maintenance dose) and propofol at 2 mg.kg(-1) 3 min later. The combined automatic control was started 2 min after tracheal intubation. The depth of anaesthesia was recorded using bispectral index monitoring using a target value of 40. The target value of neuromuscular blockade, using mivacurium, was a T1/T1(0) twitch height of 10%. The precision of the system was calculated using internationally defined performance parameters. Twenty patients were included in the data analysis. The mean (SD) duration of simultaneous control was 129 (69) min. No human intervention was necessary during the computer-controlled administration of propofol and mivacurium. All patients assessed the quality of anaesthesia as 'good' to 'very good'; there were no episodes of awareness. The mean (SD) median performance error, median absolute performance error and wobble for the control of depth of anaesthesia and for neuromuscular blockade were -0.31 (1.78), 6.76 (3.45), 6.32 (2.93) and -0.38 (1.68), 3.75 (4.83), 3.63 (4.69), respectively. The simultaneous closed-loop system using propofol and mivacurium was able to maintain the target values with a high level of precision in a clinical setting. © 2011 The Authors. Anaesthesia © 2011 The Association of Anaesthetists of Great Britain and Ireland.

A risk-adjusted O-E CUSUM with monitoring bands for monitoring medical outcomes.

PubMed

Sun, Rena Jie; Kalbfleisch, John D

2013-03-01

In order to monitor a medical center's survival outcomes using simple plots, we introduce a risk-adjusted Observed-Expected (O-E) Cumulative SUM (CUSUM) along with monitoring bands as decision criterion.The proposed monitoring bands can be used in place of a more traditional but complicated V-shaped mask or the simultaneous use of two one-sided CUSUMs. The resulting plot is designed to simultaneously monitor for failure time outcomes that are "worse than expected" or "better than expected." The slopes of the O-E CUSUM provide direct estimates of the relative risk (as compared to a standard or expected failure rate) for the data being monitored. Appropriate rejection regions are obtained by controlling the false alarm rate (type I error) over a period of given length. Simulation studies are conducted to illustrate the performance of the proposed method. A case study is carried out for 58 liver transplant centers. The use of CUSUM methods for quality improvement is stressed. Copyright © 2013, The International Biometric Society.

Assessing the Impact of Observations on Numerical Weather Forecasts Using the Adjoint Method

NASA Technical Reports Server (NTRS)

Gelaro, Ronald

2012-01-01

The adjoint of a data assimilation system provides a flexible and efficient tool for estimating observation impacts on short-range weather forecasts. The impacts of any or all observations can be estimated simultaneously based on a single execution of the adjoint system. The results can be easily aggregated according to data type, location, channel, etc., making this technique especially attractive for examining the impacts of new hyper-spectral satellite instruments and for conducting regular, even near-real time, monitoring of the entire observing system. This talk provides a general overview of the adjoint method, including the theoretical basis and practical implementation of the technique. Results are presented from the adjoint-based observation impact monitoring tool in NASA's GEOS-5 global atmospheric data assimilation and forecast system. When performed in conjunction with standard observing system experiments (OSEs), the adjoint results reveal both redundancies and dependencies between observing system impacts as observations are added or removed from the assimilation system. Understanding these dependencies may be important for optimizing the use of the current observational network and defining requirements for future observing systems

Inductive passive sensor for intraparenchymal and intraventricular monitoring of intracranial pressure.

PubMed

Behfar, Mohammad H; Abada, Emily; Sydanheimo, Lauri; Goldman, Ken; Fleischman, Aaron J; Gupta, Nalin; Ukkonen, Leena; Roy, Shuvo

2016-08-01

Accurate measurement of intracranial hypertension is crucial for the management of elevated intracranial pressure (ICP). Catheter-based intraventricular ICP measurement is regarded as the gold standard for accurate ICP monitoring. However, this method is invasive, time-limited, and associated with complications. In this paper, we propose an implantable passive sensor that could be used for continuous intraparenchymal and intraventricular ICP monitoring. Moreover, the sensor can be placed simultaneously along with a cerebrospinal fluid shunt system in order to monitor its function. The sensor consists of a flexible coil which is connected to a miniature pressure sensor via an 8-cm long, ultra-thin coaxial cable. An external orthogonal-coil RF probe communicates with the sensor to detect pressure variation. The performance of the sensor was evaluated in an in vitro model for intraparenchymal and intraventricular ICP monitoring. The findings from this study demonstrate proof-of-concept of intraparenchymal and intraventricular ICP measurement using inductive passive pressure sensors.

A robust quantitative near infrared modeling approach for blend monitoring.

PubMed

Mohan, Shikhar; Momose, Wataru; Katz, Jeffrey M; Hossain, Md Nayeem; Velez, Natasha; Drennen, James K; Anderson, Carl A

2018-01-30

This study demonstrates a material sparing Near-Infrared modeling approach for powder blend monitoring. In this new approach, gram scale powder mixtures are subjected to compression loads to simulate the effect of scale using an Instron universal testing system. Models prepared by the new method development approach (small-scale method) and by a traditional method development (blender-scale method) were compared by simultaneously monitoring a 1kg batch size blend run. Both models demonstrated similar model performance. The small-scale method strategy significantly reduces the total resources expended to develop Near-Infrared calibration models for on-line blend monitoring. Further, this development approach does not require the actual equipment (i.e., blender) to which the method will be applied, only a similar optical interface. Thus, a robust on-line blend monitoring method can be fully developed before any large-scale blending experiment is viable, allowing the blend method to be used during scale-up and blend development trials. Copyright © 2017. Published by Elsevier B.V.

Fiber Bragg grating sensors for real-time monitoring of evacuation process

NASA Astrophysics Data System (ADS)

Guru Prasad, A. S.; Hegde, Gopalkrishna M.; Asokan, S.

2010-03-01

Fiber bragg grating (FBG) sensors have been widely used for number of sensing applications like temperature, pressure, acousto-ultrasonic, static and dynamic strain, refractive index change measurements and so on. Present work demonstrates the use of FBG sensors in in-situ measurement of vacuum process with simultaneous leak detection capability. Experiments were conducted in a bell jar vacuum chamber facilitated with conventional Pirani gauge for vacuum measurement. Three different experiments have been conducted to validate the performance of FBG sensor in monitoring vacuum creating process and air bleeding. The preliminary results of FBG sensors in vacuum monitoring have been compared with that of commercial Pirani gauge sensor. This novel technique offers a simple alternative to conventional method for real time monitoring of evacuation process. Proposed FBG based vacuum sensor has potential applications in vacuum systems involving hazardous environment such as chemical and gas plants, automobile industries, aeronautical establishments and leak monitoring in process industries, where the electrical or MEMS based sensors are prone to explosion and corrosion.

Competitive Reporter Monitored Amplification (CMA) - Quantification of Molecular Targets by Real Time Monitoring of Competitive Reporter Hybridization

PubMed Central

Ullrich, Thomas; Ermantraut, Eugen; Schulz, Torsten; Steinmetzer, Katrin

2012-01-01

Background State of the art molecular diagnostic tests are based on the sensitive detection and quantification of nucleic acids. However, currently established diagnostic tests are characterized by elaborate and expensive technical solutions hindering the development of simple, affordable and compact point-of-care molecular tests. Methodology and Principal Findings The described competitive reporter monitored amplification allows the simultaneous amplification and quantification of multiple nucleic acid targets by polymerase chain reaction. Target quantification is accomplished by real-time detection of amplified nucleic acids utilizing a capture probe array and specific reporter probes. The reporter probes are fluorescently labeled oligonucleotides that are complementary to the respective capture probes on the array and to the respective sites of the target nucleic acids in solution. Capture probes and amplified target compete for reporter probes. Increasing amplicon concentration leads to decreased fluorescence signal at the respective capture probe position on the array which is measured after each cycle of amplification. In order to observe reporter probe hybridization in real-time without any additional washing steps, we have developed a mechanical fluorescence background displacement technique. Conclusions and Significance The system presented in this paper enables simultaneous detection and quantification of multiple targets. Moreover, the presented fluorescence background displacement technique provides a generic solution for real time monitoring of binding events of fluorescently labelled ligands to surface immobilized probes. With the model assay for the detection of human immunodeficiency virus type 1 and 2 (HIV 1/2), we have been able to observe the amplification kinetics of five targets simultaneously and accommodate two additional hybridization controls with a simple instrument set-up. The ability to accommodate multiple controls and targets into a single assay and to perform the assay on simple and robust instrumentation is a prerequisite for the development of novel molecular point of care tests. PMID:22539973

Variable Temperature Nuclear Magnetic Resonance and Magnetic Resonance Imaging System as a Novel Technique for In Situ Monitoring of Food Phase Transition.

PubMed

Song, Yukun; Cheng, Shasha; Wang, Huihui; Zhu, Bei-Wei; Zhou, Dayong; Yang, Peiqiang; Tan, Mingqian

2018-01-24

A nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) system with a 45 mm variable temperature (VT) sample probe (VT-NMR-MRI) was developed as an innovative technique for in situ monitoring of food phase transition. The system was designed to allow for dual deployment in either a freezing (-37 °C) or high temperature (150 °C) environment. The major breakthrough of the developed VT-NMR-MRI system is that it is able to measure the water states simultaneously in situ during food processing. The performance of the VT-NMR-MRI system was evaluated by measuring the phase transition for salmon flesh and hen egg samples. The NMR relaxometry results demonstrated that the freezing point of salmon flesh was -8.08 °C, and the salmon flesh denaturation temperature was 42.16 °C. The protein denaturation of egg was 70.61 °C, and the protein denaturation occurred at 24.12 min. Meanwhile, the use of MRI in phase transition of food was also investigated to gain internal structural information. All these results showed that the VT-NMR-MRI system provided an effective means for in situ monitoring of phase transition in food processing.

USE OF CITIZEN BIRD POPULATION MONITORING DATA FOR ECOLOGICAL RISK ASSESSMENT

EPA Science Inventory

Birds are among the most conspicuous and easily monitored indicators of environmental health and change. Although volunteer avian monitoring ('citizen science') programs provide unique opportunities to gather data at fine and broad geographic scales simultaneously, and over long...

DNA Probe Design for Preflight and Inflight Microbial Monitoring

NASA Technical Reports Server (NTRS)

Fox, George E.

1999-01-01

Crew health is a dominant issue in manned space flight. Microbiological concerns, in particular, have repeatedly emerged as determinants of flight readiness. For example, in at least one case, suspected contamination of the potable water supply nearly forced a launch delay. In another instance, a crew member's urinary tract infection nearly led to early termination of the mission, in part due to the difficulty of accurately diagnosing the nature of the infection in-flight. Microbial problems are an increasing concern with the trend towards longer-duration missions. It is essential to the success of such missions that systems that deliver acceptable quality of air and water during the anticipated lifetime of the spacecraft be available. As mission duration and resupply intervals increase, it will be necessary to rely on advanced life support systems which incorporate both biological and physical-chemical recycling methods for air and water as well as provide food for the crew. It therefore is necessary to develop real-time, robust, in-flight monitoring procedures that are sensitive enough to detect less than 100 CFU (colony forming units) of bacteria per 100 milliliters of water. It would be desirable if the monitoring system could be readily "reprogrammed" to identify specific pathogens if an in-flight incident were to occur. Thus, the monitoring technology must simultaneously detect many organisms of interest, be subject to miniaturization and be highly automated The long range goal of project is to develop such monitoring systems.

Chirped fiber Bragg grating written in highly birefringent fiber in simultaneous strain and temperature monitoring.

PubMed

Bieda, Marcin S; Sobotka, Piotr; Woliński, Tomasz R

2017-02-20

A new sensor configuration is proposed for simultaneous strain and temperature monitoring in a composite material that is based on a chirped fiber Bragg grating (CFBG) written in a highly birefringent (HB) polarization-maintaining fiber. The sensor is designed in the reflective configuration in which the CFBG acts both as a reflector and a sensing element. Since CFBG and HB fiber induce changes in the state of polarization (SOP), interference between polarization modes in the reflected spectrum is observed and analyzed. We used a simple readout setup to enable fast, linear operation of strain sensing as well simultaneous strain and temperature measurements in the composite.

A mainstream monitoring system for respiratory CO2 concentration and gasflow.

PubMed

Yang, Jiachen; Chen, Bobo; Burk, Kyle; Wang, Haitao; Zhou, Jianxiong

2016-08-01

Continuous respiratory gas monitoring is an important tool for clinical monitoring. In particular, measurement of respiratory [Formula: see text] concentration and gasflow can reflect the status of a patient by providing parameters such as volume of carbon dioxide, end-tidal [Formula: see text] respiratory rate and alveolar deadspace. However, in the majority of previous work, [Formula: see text] concentration and gasflow have been studied separately. This study focuses on a mainstream system which simultaneously measures respiratory [Formula: see text] concentration and gasflow at the same location, allowing for volumetric capnography to be implemented. A non-dispersive infrared monitor is used to measure [Formula: see text] concentration and a differential pressure sensor is used to measure gasflow. In developing this new device, we designed a custom airway adapter which can be placed in line with the breathing circuit and accurately monitor relevant respiratory parameters. Because the airway adapter is used both for capnography and gasflow, our system reduces mechanical deadspace. The finite element method was used to design the airway adapter which can provide a strong differential pressure while reducing airway resistance. Statistical analysis using the coefficient of variation was performed to find the optimal driving voltage of the pressure transducer. Calibration between variations and flows was used to avoid pressure signal drift. We carried out targeted experiments using the proposed device and confirmed that the device can produce stable signals.

Heterogeneous recurrence monitoring and control of nonlinear stochastic processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Hui, E-mail: huiyang@usf.edu; Chen, Yun

Recurrence is one of the most common phenomena in natural and engineering systems. Process monitoring of dynamic transitions in nonlinear and nonstationary systems is more concerned with aperiodic recurrences and recurrence variations. However, little has been done to investigate the heterogeneous recurrence variations and link with the objectives of process monitoring and anomaly detection. Notably, nonlinear recurrence methodologies are based on homogeneous recurrences, which treat all recurrence states in the same way as black dots, and non-recurrence is white in recurrence plots. Heterogeneous recurrences are more concerned about the variations of recurrence states in terms of state properties (e.g., valuesmore » and relative locations) and the evolving dynamics (e.g., sequential state transitions). This paper presents a novel approach of heterogeneous recurrence analysis that utilizes a new fractal representation to delineate heterogeneous recurrence states in multiple scales, including the recurrences of both single states and multi-state sequences. Further, we developed a new set of heterogeneous recurrence quantifiers that are extracted from fractal representation in the transformed space. To that end, we integrated multivariate statistical control charts with heterogeneous recurrence analysis to simultaneously monitor two or more related quantifiers. Experimental results on nonlinear stochastic processes show that the proposed approach not only captures heterogeneous recurrence patterns in the fractal representation but also effectively monitors the changes in the dynamics of a complex system.« less

Twenty-Four-Hour Real-Time Continuous Monitoring of Cerebral Edema in Rabbits Based on a Noninvasive and Noncontact System of Magnetic Induction

PubMed Central

Li, Gen; Ma, Ke; Sun, Jian; Jin, Gui; Qin, Mingxin; Feng, Hua

2017-01-01

Cerebral edema is a common disease, secondary to craniocerebral injury, and real-time continuous monitoring of cerebral edema is crucial for treating patients after traumatic brain injury. This work established a noninvasive and noncontact system by monitoring the magnetic induction phase shift (MIPS) which is associated with brain tissue conductivity. Sixteen rabbits (experimental group n = 10, control group, n = 6) were used to perform a 24 h MIPS and intracranial pressure (ICP) simultaneously monitored experimental study. For the experimental group, after the establishment of epidural freeze-induced cerebral edema models, the MIPS presented a downward trend within 24 h, with a change magnitude of −13.1121 ± 2.3953°; the ICP presented an upward trend within 24 h, with a change magnitude of 12–41 mmHg. The ICP was negatively correlated with the MIPS. In the control group, the MIPS change amplitude was −0.87795 ± 1.5146 without obvious changes; the ICP fluctuated only slightly at the initial value of 12 mmHg. MIPS had a more sensitive performance than ICP in the early stage of cerebral edema. These results showed that this system is basically capable of monitoring gradual increases in the cerebral edema solution volume. To some extent, the MIPS has the potential to reflect the ICP changes. PMID:28282851

Simultaneous detection of perchlorate and bromate using rapid high-performance ion exchange chromatography-tandem mass spectrometry and perchlorate removal in drinking water.

PubMed

West, Danielle M; Mu, Ruipu; Gamagedara, Sanjeewa; Ma, Yinfa; Adams, Craig; Eichholz, Todd; Burken, Joel G; Shi, Honglan

2015-06-01

Perchlorate and bromate occurrence in drinking water causes health concerns due to their effects on thyroid function and carcinogenicity, respectively. The purpose of this study was threefold: (1) to advance a sensitive method for simultaneous rapid detection of perchlorate and bromate in drinking water system, (2) to systematically study the occurrence of these two contaminants in Missouri drinking water treatment systems, and (3) to examine effective sorbents for minimizing perchlorate in drinking water. A rapid high-performance ion exchange chromatography-tandem mass spectrometry (HPIC-MS/MS) method was advanced for simultaneous detection of perchlorate and bromate in drinking water. The HPIC-MS/MS method was rapid, required no preconcentration of the water samples, and had detection limits for perchlorate and bromate of 0.04 and 0.01 μg/L, respectively. The method was applied to determine perchlorate and bromate concentrations in total of 23 selected Missouri drinking water treatment systems during differing seasons. The water systems selected include different source waters: groundwater, lake water, river water, and groundwater influenced by surface water. The concentrations of perchlorate and bromate were lower than or near to method detection limits in most of the drinking water samples monitored. The removal of perchlorate by various adsorbents was studied. A cationic organoclay (TC-99) exhibited effective removal of perchlorate from drinking water matrices.

Combining Optical Coherence Tomography with Fluorescence Molecular Imaging: Towards Simultaneous Morphology and Molecular Imaging

PubMed Central

Yuan, Shuai; Roney, Celeste A.; Wierwille, Jerry; Chen, Chao-Wei; Xu, Biying; Jiang, James; Ma, Hongzhou; Cable, Alex; Summers, Ronald M.; Chen, Yu

2010-01-01

Optical coherence tomography (OCT) provides high-resolution, cross-sectional imaging of tissue microstructure in situ and in real-time, while fluorescence molecular imaging (FMI) enables the visualization of basic molecular processes. There are great interests in combining these two modalities so that the tissue's structural and molecular information can be obtained simultaneously. This could greatly benefit biomedical applications such as detecting early diseases and monitoring therapeutic interventions. In this research, an optical system that combines OCT and FMI was developed. The system demonstrated that it could co-register en face OCT and FMI images with a 2.4 × 2.4 mm field of view. The transverse resolutions of OCT and FMI of the system are both ~10 μm. Capillary tubes filled with fluorescent dye Cy 5.5 in different concentrations under a scattering medium are used as the phantom. En face OCT images of the phantoms were obtained and successfully co-registered with FMI images that were acquired simultaneously. A linear relationship between FMI intensity and dye concentration was observed. The relationship between FMI intensity and target fluorescence tube depth measured by OCT images was also observed and compared with theoretical modeling. This relationship could help in correcting reconstructed dye concentration. Imaging of colon polyps of APCmin mouse model is presented as an example of biological applications of this co-registered OCT/FMI system. PMID:20009192

Simultaneous assimilation of ozone profiles from multiple UV-VIS satellite instruments

NASA Astrophysics Data System (ADS)

van Peet, Jacob C. A.; van der A, Ronald J.; Kelder, Hennie M.; Levelt, Pieternel F.

2018-02-01

A three-dimensional global ozone distribution has been derived from assimilation of ozone profiles that were observed by satellites. By simultaneous assimilation of ozone profiles retrieved from the nadir looking satellite instruments Global Ozone Monitoring Experiment 2 (GOME-2) and Ozone Monitoring Instrument (OMI), which measure the atmosphere at different times of the day, the quality of the derived atmospheric ozone field has been improved. The assimilation is using an extended Kalman filter in which chemical transport model TM5 has been used for the forecast. The combined assimilation of both GOME-2 and OMI improves upon the assimilation results of a single sensor. The new assimilation system has been demonstrated by processing 4 years of data from 2008 to 2011. Validation of the assimilation output by comparison with sondes shows that biases vary between -5 and +10 % between the surface and 100 hPa. The biases for the combined assimilation vary between -3 and +3 % in the region between 100 and 10 hPa where GOME-2 and OMI are most sensitive. This is a strong improvement compared to direct retrievals of ozone profiles from satellite observations.

Bayesian Inference for Signal-Based Seismic Monitoring

NASA Astrophysics Data System (ADS)

Moore, D.

2015-12-01

Traditional seismic monitoring systems rely on discrete detections produced by station processing software, discarding significant information present in the original recorded signal. SIG-VISA (Signal-based Vertically Integrated Seismic Analysis) is a system for global seismic monitoring through Bayesian inference on seismic signals. By modeling signals directly, our forward model is able to incorporate a rich representation of the physics underlying the signal generation process, including source mechanisms, wave propagation, and station response. This allows inference in the model to recover the qualitative behavior of recent geophysical methods including waveform matching and double-differencing, all as part of a unified Bayesian monitoring system that simultaneously detects and locates events from a global network of stations. We demonstrate recent progress in scaling up SIG-VISA to efficiently process the data stream of global signals recorded by the International Monitoring System (IMS), including comparisons against existing processing methods that show increased sensitivity from our signal-based model and in particular the ability to locate events (including aftershock sequences that can tax analyst processing) precisely from waveform correlation effects. We also provide a Bayesian analysis of an alleged low-magnitude event near the DPRK test site in May 2010 [1] [2], investigating whether such an event could plausibly be detected through automated processing in a signal-based monitoring system. [1] Zhang, Miao and Wen, Lianxing. "Seismological Evidence for a Low-Yield Nuclear Test on 12 May 2010 in North Korea". Seismological Research Letters, January/February 2015. [2] Richards, Paul. "A Seismic Event in North Korea on 12 May 2010". CTBTO SnT 2015 oral presentation, video at https://video-archive.ctbto.org/index.php/kmc/preview/partner_id/103/uiconf_id/4421629/entry_id/0_ymmtpps0/delivery/http

Quantification of methionine and selenomethionine in biological samples using multiple reaction monitoring high performance liquid chromatography tandem mass spectrometry (MRM-HPLC-MS/MS).

PubMed

Vu, Dai Long; Ranglová, Karolína; Hájek, Jan; Hrouzek, Pavel

2018-05-01

Quantification of selenated amino-acids currently relies on methods employing inductively coupled plasma mass spectrometry (ICP-MS). Although very accurate, these methods do not allow the simultaneous determination of standard amino-acids, hampering the comparison of the content of selenated versus non-selenated species such as methionine (Met) and selenomethionine (SeMet). This paper reports two approaches for the simultaneous quantification of Met and SeMet. In the first approach, standard enzymatic hydrolysis employing Protease XIV was applied for the preparation of samples. The second approach utilized methanesulfonic acid (MA) for the hydrolysis of samples, either in a reflux system or in a microwave oven, followed by derivatization with diethyl ethoxymethylenemalonate. The prepared samples were then analyzed by multiple reaction monitoring high performance liquid chromatography tandem mass spectrometry (MRM-HPLC-MS/MS). Both approaches provided platforms for the accurate determination of selenium/sulfur substitution rate in Met. Moreover the second approach also provided accurate simultaneous quantification of Met and SeMet with a low limit of detection, low limit of quantification and wide linearity range, comparable to the commonly used gas chromatography mass spectrometry (GC-MS) method or ICP-MS. The novel method was validated using certified reference material in conjunction with the GC-MS reference method. Copyright © 2018. Published by Elsevier B.V.

An approach to improve the spatial resolution of a force mapping sensing system

NASA Astrophysics Data System (ADS)

Negri, Lucas Hermann; Manfron Schiefer, Elberth; Sade Paterno, Aleksander; Muller, Marcia; Luís Fabris, José

2016-02-01

This paper proposes a smart sensor system capable of detecting sparse forces applied to different positions of a metal plate. The sensing is performed with strain transducers based on fiber Bragg gratings (FBG) distributed under the plate. Forces actuating in nine squared regions of the plate, resulting from up to three different loads applied simultaneously to the plate, were monitored with seven transducers. The system determines the magnitude of the force/pressure applied on each specific area, even in the absence of a dedicated transducer for that area. The set of strain transducers with coupled responses and a compressive sensing algorithm are employed to solve the underdetermined inverse problem which emerges from mapping the force. In this configuration, experimental results have shown that the system is capable of recovering the value of the load distributed on the plate with a signal-to-noise ratio better than 12 dB, when the plate is submitted to three simultaneous test loads. The proposed method is a practical illustration of compressive sensing algorithms for the reduction of the number of FBG-based transducers used in a quasi-distributed configuration.

GNSS-based multi-sensor system for structural monitoring applications

NASA Astrophysics Data System (ADS)

Bogusz, Janusz; Figurski, Mariusz; Nykiel, Grzegorz; Szolucha, Marcin; Wrona, Maciej

2012-03-01

In 2007 the Centre of Applied Geomatics of the Military University of Technology started measurements aimed at the monitoring of the dynamic state of the engineering structures using GNSS. The complexity of the problem forced us to apply an integrated system architecture. This concept is based on simultaneous measuring some selected elements of the structure using various types of sensors. Measurement information from numerous instruments is numerically integrated for determining the investigated parameter, e.g., the displacement vector. The CAG team performed the tests using such a system on the two permanent 500-meters long bridges, the temporary bridge crossing for military purposes and the 300-meters high chimney of the CHP station. The information about displacement vector together with the characteristic frequencies of the structure were determined using different techniques for increasing of its reliability. This paper presents the results of such tests, gives description of the integrated system designed in the CAG and brings forward with the plans for the future.

Audio distribution and Monitoring Circuit

NASA Technical Reports Server (NTRS)

Kirkland, J. M.

1983-01-01

Versatile circuit accepts and distributes TV audio signals. Three-meter audio distribution and monitoring circuit provides flexibility in monitoring, mixing, and distributing audio inputs and outputs at various signal and impedance levels. Program material is simultaneously monitored on three channels, or single-channel version built to monitor transmitted or received signal levels, drive speakers, interface to building communications, and drive long-line circuits.

Analysis of oxidative stress biomarkers using a simultaneous competitive/non-competitive micromosaic immunoassay.

PubMed

Murphy, Brian M; Dandy, David S; Henry, Charles S

2009-04-27

Immunoassays represent a core workhorse methodology for many applications ranging from clinical diagnostics to environmental monitoring. In traditional formats such as the enzyme linked immunosorbent assay (ELISA), analytes are measured singly or in small sets. As more biomarkers are identified for disease states, there is a need to develop methods that can measure multiple markers simultaneously. Immunoaffinity arrays are one such chemistry that can achieve multi-marker screening. Most arrays are performed in either competitive or non-competitive formats, where the former are used predominantly for small molecules and the later for macromolecules. To date, ELISA and immunoaffinity array methods have relied exclusively on one of these formats and not the other. Here an immunoaffinity array method capable of performing simultaneous competitive and non-competitive analysis generated using micromosaic immunoassay techniques is introduced for the analysis of metabolites and proteins. In this report, three markers of oxidative stress were used as a model system. The method described here demonstrates the simultaneous analysis of 3-nitrotyrosine, by indirect competitive immunoassay while the enzymes catalase and superoxide dismutase are analyzed by non-competitive sandwich immunoassay. The method requires less than 1 microL sample and 45 min for completion. Logistic curve fits and LOD (limits of detection) statistical analysis of the binding results are presented and show good agreement with published data for these antibody-antigen systems.

The Effects of Active Learning Programs in Multigrade Schools on Girls' Persistence in and Completion of Primary School in Developing Countries. Girls' Education Monitoring System (GEMS).

ERIC Educational Resources Information Center

Juarez and Associates, Inc., Los Angeles, CA.

Multigrade schooling is a strategy to increase the educational opportunities of children in situations where it is impractical to have one primary school teacher per grade because of the limited size of the student population. In a multigrade school, teachers manage two or more classes simultaneously. A single teacher may be responsible for all…

Intelligent monitoring of critical pathological events during anesthesia.

PubMed

Gohil, Bhupendra; Gholamhhosseini, Hamid; Harrison, Michael J; Lowe, Andrew; Al-Jumaily, Ahmed

2007-01-01

Expert algorithms in the field of intelligent patient monitoring have rapidly revolutionized patient care thereby improving patient safety. Patient monitoring during anesthesia requires cautious attention by anesthetists who are monitoring many modalities, diagnosing clinically critical events and performing patient management tasks simultaneously. The mishaps that occur during day-to-day anesthesia causing disastrous errors in anesthesia administration were classified and studied by Reason [1]. Human errors in anesthesia account for 82% of the preventable mishaps [2]. The aim of this paper is to develop a clinically useful diagnostic alarm system for detecting critical events during anesthesia administration. The development of an expert diagnostic alarm system called ;RT-SAAM' for detecting critical pathological events in the operating theatre is presented. This system provides decision support to the anesthetist by presenting the diagnostic results on an integrative, ergonomic display and thus enhancing patient safety. The performance of the system was validated through a series of offline and real-time testing in the operation theatre. When detecting absolute hypovolaemia (AHV), moderate level of agreement was observed between RT-SAAM and the human expert (anesthetist) during surgical procedures. RT-SAAM is a clinically useful diagnostic tool which can be easily modified for diagnosing additional critical pathological events like relative hypovolaemia, fall in cardiac output, sympathetic response and malignant hyperpyrexia during surgical procedures. RT-SAAM is currently being tested at the Auckland City Hospital with ethical approval from the local ethics committees.

In-line assay monitor for uranium hexafluoride

DOEpatents

Wallace, Steven A.

1981-01-01

An in-line assay monitor for determining the content of uranium-235 in a uranium hexafluoride gas isotopic separation system is provided which removes the necessity of complete access to the operating parameters of the system for determining the uranium-235 content. The monitor is intended for uses such as safeguard applications to assure that weapons grade uranium is not being produced in an enrichment cascade. The method and monitor for carrying out the method involve cooling of a radiation pervious chamber connected in fluid communication with the selected point in the system to withdraw a specimen and solidify the specimen in the chamber. The specimen is irradiated by means of an ionizing radiation source of energy different from that of the 185 keV gamma emissions from the uranium-235 present in the specimen. Simultaneously, the gamma emissions from the uranium-235 of the specimen and the source emissions transmitted through the sample are counted and stored in a multiple channel analyzer. The uranium-235 content of the specimen is determined from the comparison of the accumulated 185 keV energy counts and the reference energy counts. The latter is used to measure the total uranium isotopic content of the specimen. The process eliminates the necessity of knowing the system operating conditions and yet obtains the necessary data without need for large scintillation crystals and sophisticated mechanical designs.

A real-time diagnostic and performance monitor for UNIX. M.S. Thesis

NASA Technical Reports Server (NTRS)

Dong, Hongchao

1992-01-01

There are now over one million UNIX sites and the pace at which new installations are added is steadily increasing. Along with this increase, comes a need to develop simple efficient, effective and adaptable ways of simultaneously collecting real-time diagnostic and performance data. This need exists because distributed systems can give rise to complex failure situations that are often un-identifiable with single-machine diagnostic software. The simultaneous collection of error and performance data is also important for research in failure prediction and error/performance studies. This paper introduces a portable method to concurrently collect real-time diagnostic and performance data on a distributed UNIX system. The combined diagnostic/performance data collection is implemented on a distributed multi-computer system using SUN4's as servers. The approach uses existing UNIX system facilities to gather system dependability information such as error and crash reports. In addition, performance data such as CPU utilization, disk usage, I/O transfer rate and network contention is also collected. In the future, the collected data will be used to identify dependability bottlenecks and to analyze the impact of failures on system performance.

Ground-based atmospheric water vapor monitoring system with spectroscopy of radiation in 20-30 GHz and 50-60 GHz bands

NASA Astrophysics Data System (ADS)

Nagasaki, Takeo; Tajima, Osamu; Araki, Kentaro; Ishimoto, Hiroshi

2016-07-01

We propose a novel ground-based meteorological monitoring system. In the 20{30 GHz band, our system simultaneously measures a broad absorption peak of water vapor and cloud liquid water. Additional observation in the 50{60 GHz band obtains the radiation of oxygen. Spectral results contain vertical profiles of the physical temperature of atmospheric molecules. We designed a simple method for placing the system atop high buildings and mountains and on decks of ships. There is a simple optical system in front of horn antennas for each frequency band. A focused signal from a reflector is separated into two polarized optical paths by a wire grid. Each signal received by the horn antenna is amplified by low-noise amplifiers. Spectra of each signal are measured as a function of frequency using two analyzers. A blackbody calibration source is maintained at 50 K in a cryostat. The calibration signal is led to each receiver via the wire grid. The input path of the signal is selected by rotation of the wire grid by 90°, because the polarization axis of the reflected path and axis of the transparent path are orthogonal. We developed a prototype receiver and demonstrated its performance using monitoring at the zenith.

Design of a Novel Flexible Capacitive Sensing Mattress for Monitoring Sleeping Respiratory

PubMed Central

Chang, Wen-Ying; Huang, Chien-Chun; Chen, Chi-Chun; Chang, Chih-Cheng; Yang, Chin-Lung

2014-01-01

In this paper, an algorithm to extract respiration signals using a flexible projected capacitive sensing mattress (FPCSM) designed for personal health assessment is proposed. Unlike the interfaces of conventional measurement systems for poly-somnography (PSG) and other alternative contemporary systems, the proposed FPCSM uses projected capacitive sensing capability that is not worn or attached to the body. The FPCSM is composed of a multi-electrode sensor array that can not only observe gestures and motion behaviors, but also enables the FPCSM to function as a respiration monitor during sleep using the proposed approach. To improve long-term monitoring when body movement is possible, the FPCSM enables the selection of data from the sensing array, and the FPCSM methodology selects the electrodes with the optimal signals after the application of a channel reduction algorithm that counts the reversals in the capacitive sensing signals as a quality indicator. The simple algorithm is implemented in the time domain. The FPCSM system is used in experimental tests and is simultaneously compared with a commercial PSG system for verification. Multiple synchronous measurements are performed from different locations of body contact, and parallel data sets are collected. The experimental comparison yields a correlation coefficient of 0.88 between FPCSM and PSG, demonstrating the feasibility of the system design. PMID:25420152

Optical detection of blade flutter. [in YF-100 turbofan engine

NASA Technical Reports Server (NTRS)

Nieberding, W. C.; Pollack, J. L.

1977-01-01

The paper examines the capabilities of photoelectric scanning (PES) and stroboscopic imagery (SI) as optical monitoring tools for detection of the onset of flutter in the fan blades of an aircraft gas turbine engine. Both optical techniques give visual data in real time as well as video-tape records. PES is shown to be an ideal flutter monitor, since a single cathode ray tube displays the behavior of all the blades in a stage simultaneously. Operation of the SI system continuously while searching for a flutter condition imposes severe demands on the flash tube and affects its reliability, thus limiting its use as a flutter monitor. A better method of operation is to search for flutter with the PES and limit the use of SI to those times when the PES indicates interesting blade activity.

Real-Time Processing System for the JET Hard X-Ray and Gamma-Ray Profile Monitor Enhancement

NASA Astrophysics Data System (ADS)

Fernandes, Ana M.; Pereira, Rita C.; Neto, André; Valcárcel, Daniel F.; Alves, Diogo; Sousa, Jorge; Carvalho, Bernardo B.; Kiptily, Vasily; Syme, Brian; Blanchard, Patrick; Murari, Andrea; Correia, Carlos M. B. A.; Varandas, Carlos A. F.; Gonçalves, Bruno

2014-06-01

The Joint European Torus (JET) is currently undertaking an enhancement program which includes tests of relevant diagnostics with real-time processing capabilities for the International Thermonuclear Experimental Reactor (ITER). Accordingly, a new real-time processing system was developed and installed at JET for the gamma-ray and hard X-ray profile monitor diagnostic. The new system is connected to 19 CsI(Tl) photodiodes in order to obtain the line-integrated profiles of the gamma-ray and hard X-ray emissions. Moreover, it was designed to overcome the former data acquisition (DAQ) limitations while exploiting the required real-time features. The new DAQ hardware, based on the Advanced Telecommunication Computer Architecture (ATCA) standard, includes reconfigurable digitizer modules with embedded field-programmable gate array (FPGA) devices capable of acquiring and simultaneously processing data in real-time from the 19 detectors. A suitable algorithm was developed and implemented in the FPGAs, which are able to deliver the corresponding energy of the acquired pulses. The processed data is sent periodically, during the discharge, through the JET real-time network and stored in the JET scientific databases at the end of the pulse. The interface between the ATCA digitizers, the JET control and data acquisition system (CODAS), and the JET real-time network is provided by the Multithreaded Application Real-Time executor (MARTe). The work developed allowed attaining two of the major milestones required by next fusion devices: the ability to process and simultaneously supply high volume data rates in real-time.

Comprehensive study of solid pharmaceutical tablets in visible, near infrared (NIR), and longwave infrared (LWIR) spectral regions using a rapid simultaneous ultraviolet/visible/NIR (UVN) + LWIR laser-induced breakdown spectroscopy linear arrays detection system and a fast acousto-optic tunable filter NIR spectrometer.

PubMed

Yang, Clayton S C; Jin, Feng; Swaminathan, Siva R; Patel, Sita; Ramer, Evan D; Trivedi, Sudhir B; Brown, Ei E; Hommerich, Uwe; Samuels, Alan C

2017-10-30

This is the first report of a simultaneous ultraviolet/visible/NIR and longwave infrared laser-induced breakdown spectroscopy (UVN + LWIR LIBS) measurement. In our attempt to study the feasibility of combining the newly developed rapid LWIR LIBS linear array detection system to existing rapid analytical techniques for a wide range of chemical analysis applications, two different solid pharmaceutical tablets, Tylenol arthritis pain and Bufferin, were studied using both a recently designed simultaneous UVN + LWIR LIBS detection system and a fast AOTF NIR (1200 to 2200 nm) spectrometer. Every simultaneous UVN + LWIR LIBS emission spectrum in this work was initiated by one single laser pulse-induced micro-plasma in the ambient air atmosphere. Distinct atomic and molecular LIBS emission signatures of the target compounds measured simultaneously in UVN (200 to 1100 nm) and LWIR (5.6 to 10 µm) spectral regions are readily detected and identified without the need to employ complex data processing. In depth profiling studies of these two pharmaceutical tablets without any sample preparation, one can easily monitor the transition of the dominant LWIR emission signatures from coating ingredients gradually to the pharmaceutical ingredients underneath the coating. The observed LWIR LIBS emission signatures provide complementary molecular information to the UVN LIBS signatures, thus adding robustness to identification procedures. LIBS techniques are more surface specific while NIR spectroscopy has the capability to probe more bulk materials with its greater penetration depth. Both UVN + LWIR LIBS and NIR absorption spectroscopy have shown the capabilities of acquiring useful target analyte spectral signatures in comparable short time scales. The addition of a rapid LWIR spectroscopic probe to these widely used optical analytical methods, such as NIR spectroscopy and UVN LIBS, may greatly enhance the capability and accuracy of the combined system for a comprehensive analysis.

Experimental application of OMA solutions on the model of industrial structure

NASA Astrophysics Data System (ADS)

Mironov, A.; Mironovs, D.

2017-10-01

It is very important and sometimes even vital to maintain reliability of industrial structures. High quality control during production and structural health monitoring (SHM) in exploitation provides reliable functioning of large, massive and remote structures, like wind generators, pipelines, power line posts, etc. This paper introduces a complex of technological and methodical solutions for SHM and diagnostics of industrial structures, including those that are actuated by periodic forces. Solutions were verified on a wind generator scaled model with integrated system of piezo-film deformation sensors. Simultaneous and multi-patch Operational Modal Analysis (OMA) approaches were implemented as methodical means for structural diagnostics and monitoring. Specially designed data processing algorithms provide objective evaluation of structural state modification.

Changes to CMS Reimbursement Rules for Intraoperative Neurophysiological Monitoring: Implications for Telemedicine

PubMed Central

2013-01-01

Abstract Intraoperative neurophysiological monitoring (IONM) is used as an adjunct for surgeries that pose risk to nervous system structures. IONM is performed by a technologist in the operating room and is overseen by a highly trained fellowship-trained physician clinical neurophysiologist. Telemedicine has allowed the professional oversight component to be done remotely, with reimbursement for multiple simultaneous cases. Recent changes to Current Procedure Terminology coding and Medicare reimbursement policies provide options only for exclusive 1:1 technologist:oversight physician billing. This policy change may create profound repercussions in the practice of telemedicine by actively discouraging the leveraging of highly specialized and scarce expertise through on-site physician extenders. PMID:23952785

A low-power multi-modal body sensor network with application to epileptic seizure monitoring.

PubMed

Altini, Marco; Del Din, Silvia; Patel, Shyamal; Schachter, Steven; Penders, Julien; Bonato, Paolo

2011-01-01

Monitoring patients' physiological signals during their daily activities in the home environment is one of the challenge of the health care. New ultra-low-power wireless technologies could help to achieve this goal. In this paper we present a low-power, multi-modal, wearable sensor platform for the simultaneous recording of activity and physiological data. First we provide a description of the wearable sensor platform, and its characteristics with respect to power consumption. Second we present the preliminary results of the comparison between our sensors and a reference system, on healthy subjects, to test the reliability of the detected physiological (electrocardiogram and respiration) and electromyography signals.

IEEE 802.15.4 Frame Aggregation Enhancement to Provide High Performance in Life-Critical Patient Monitoring Systems

PubMed Central

Akbar, Muhammad Sajjad; Yu, Hongnian; Cang, Shuang

2017-01-01

In wireless body area sensor networks (WBASNs), Quality of Service (QoS) provision for patient monitoring systems in terms of time-critical deadlines, high throughput and energy efficiency is a challenging task. The periodic data from these systems generates a large number of small packets in a short time period which needs an efficient channel access mechanism. The IEEE 802.15.4 standard is recommended for low power devices and widely used for many wireless sensor networks applications. It provides a hybrid channel access mechanism at the Media Access Control (MAC) layer which plays a key role in overall successful transmission in WBASNs. There are many WBASN’s MAC protocols that use this hybrid channel access mechanism in variety of sensor applications. However, these protocols are less efficient for patient monitoring systems where life critical data requires limited delay, high throughput and energy efficient communication simultaneously. To address these issues, this paper proposes a frame aggregation scheme by using the aggregated-MAC protocol data unit (A-MPDU) which works with the IEEE 802.15.4 MAC layer. To implement the scheme accurately, we develop a traffic patterns analysis mechanism to understand the requirements of the sensor nodes in patient monitoring systems, then model the channel access to find the performance gap on the basis of obtained requirements, finally propose the design based on the needs of patient monitoring systems. The mechanism is initially verified using numerical modelling and then simulation is conducted using NS2.29, Castalia 3.2 and OMNeT++. The proposed scheme provides the optimal performance considering the required QoS. PMID:28134853

IEEE 802.15.4 Frame Aggregation Enhancement to Provide High Performance in Life-Critical Patient Monitoring Systems.

PubMed

Akbar, Muhammad Sajjad; Yu, Hongnian; Cang, Shuang

2017-01-28

In wireless body area sensor networks (WBASNs), Quality of Service (QoS) provision for patient monitoring systems in terms of time-critical deadlines, high throughput and energy efficiency is a challenging task. The periodic data from these systems generates a large number of small packets in a short time period which needs an efficient channel access mechanism. The IEEE 802.15.4 standard is recommended for low power devices and widely used for many wireless sensor networks applications. It provides a hybrid channel access mechanism at the Media Access Control (MAC) layer which plays a key role in overall successful transmission in WBASNs. There are many WBASN's MAC protocols that use this hybrid channel access mechanism in variety of sensor applications. However, these protocols are less efficient for patient monitoring systems where life critical data requires limited delay, high throughput and energy efficient communication simultaneously. To address these issues, this paper proposes a frame aggregation scheme by using the aggregated-MAC protocol data unit (A-MPDU) which works with the IEEE 802.15.4 MAC layer. To implement the scheme accurately, we develop a traffic patterns analysis mechanism to understand the requirements of the sensor nodes in patient monitoring systems, then model the channel access to find the performance gap on the basis of obtained requirements, finally propose the design based on the needs of patient monitoring systems. The mechanism is initially verified using numerical modelling and then simulation is conducted using NS2.29, Castalia 3.2 and OMNeT++. The proposed scheme provides the optimal performance considering the required QoS.

Validation of Contact-Free Sleep Monitoring Device with Comparison to Polysomnography.

PubMed

Tal, Asher; Shinar, Zvika; Shaki, David; Codish, Shlomi; Goldbart, Aviv

2017-03-15

To validate a contact-free system designed to achieve maximal comfort during long-term sleep monitoring, together with high monitoring accuracy. We used a contact-free monitoring system (EarlySense, Ltd., Israel), comprising an under-the-mattress piezoelectric sensor and a smartphone application, to collect vital signs and analyze sleep. Heart rate (HR), respiratory rate (RR), body movement, and calculated sleep-related parameters from the EarlySense (ES) sensor were compared to data simultaneously generated by the gold standard, polysomnography (PSG). Subjects in the sleep laboratory underwent overnight technician-attended full PSG, whereas subjects at home were recorded for 1 to 3 nights with portable partial PSG devices. Data were compared epoch by epoch. A total of 63 subjects (85 nights) were recorded under a variety of sleep conditions. Compared to PSG, the contact-free system showed similar values for average total sleep time (TST), % wake, % rapid eye movement, and % non-rapid eye movement sleep, with 96.1% and 93.3% accuracy of continuous measurement of HR and RR, respectively. We found a linear correlation between TST measured by the sensor and TST determined by PSG, with a coefficient of 0.98 (R = 0.87). Epoch-by-epoch comparison with PSG in the sleep laboratory setting revealed that the system showed sleep detection sensitivity, specificity, and accuracy of 92.5%, 80.4%, and 90.5%, respectively. TST estimates with the contact-free sleep monitoring system were closely correlated with the gold-standard reference. This system shows good sleep staging capability with improved performance over accelerometer-based apps, and collects additional physiological information on heart rate and respiratory rate. © 2017 American Academy of Sleep Medicine

Simultaneous Estimation of Electromechanical Modes and Forced Oscillations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Follum, Jim; Pierre, John W.; Martin, Russell

Over the past several years, great strides have been made in the effort to monitor the small-signal stability of power systems. These efforts focus on estimating electromechanical modes, which are a property of the system that dictate how generators in different parts of the system exchange energy. Though the algorithms designed for this task are powerful and important for reliable operation of the power system, they are susceptible to severe bias when forced oscillations are present in the system. Forced oscillations are fundamentally different from electromechanical oscillations in that they are the result of a rogue input to the system,more » rather than a property of the system itself. To address the presence of forced oscillations, the frequently used AutoRegressive Moving Average (ARMA) model is adapted to include sinusoidal inputs, resulting in the AutoRegressive Moving Average plus Sinusoid (ARMA+S) model. From this model, a new Two-Stage Least Squares algorithm is derived to incorporate the forced oscillations, thereby enabling the simultaneous estimation of the electromechanical modes and the amplitude and phase of the forced oscillations. The method is validated using simulated power system data as well as data obtained from the western North American power system (wNAPS) and Eastern Interconnection (EI).« less

Technical note: Simultaneous fully dynamic characterization of multiple input–output relationships in climate models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kravitz, Ben; MacMartin, Douglas G.; Rasch, Philip J.

We introduce system identification techniques to climate science wherein multiple dynamic input–output relationships can be simultaneously characterized in a single simulation. This method, involving multiple small perturbations (in space and time) of an input field while monitoring output fields to quantify responses, allows for identification of different timescales of climate response to forcing without substantially pushing the climate far away from a steady state. We use this technique to determine the steady-state responses of low cloud fraction and latent heat flux to heating perturbations over 22 regions spanning Earth's oceans. We show that the response characteristics are similar to thosemore » of step-change simulations, but in this new method the responses for 22 regions can be characterized simultaneously. Moreover, we can estimate the timescale over which the steady-state response emerges. The proposed methodology could be useful for a wide variety of purposes in climate science, including characterization of teleconnections and uncertainty quantification to identify the effects of climate model tuning parameters.« less

Technical note: Simultaneous fully dynamic characterization of multiple input–output relationships in climate models

DOE PAGES

Kravitz, Ben; MacMartin, Douglas G.; Rasch, Philip J.; ...

2017-02-17

We introduce system identification techniques to climate science wherein multiple dynamic input–output relationships can be simultaneously characterized in a single simulation. This method, involving multiple small perturbations (in space and time) of an input field while monitoring output fields to quantify responses, allows for identification of different timescales of climate response to forcing without substantially pushing the climate far away from a steady state. We use this technique to determine the steady-state responses of low cloud fraction and latent heat flux to heating perturbations over 22 regions spanning Earth's oceans. We show that the response characteristics are similar to thosemore » of step-change simulations, but in this new method the responses for 22 regions can be characterized simultaneously. Moreover, we can estimate the timescale over which the steady-state response emerges. The proposed methodology could be useful for a wide variety of purposes in climate science, including characterization of teleconnections and uncertainty quantification to identify the effects of climate model tuning parameters.« less

Spalax™ new generation: A sensitive and selective noble gas system for nuclear explosion monitoring.

PubMed

Le Petit, G; Cagniant, A; Gross, P; Douysset, G; Topin, S; Fontaine, J P; Taffary, T; Moulin, C

2015-09-01

In the context of the verification regime of the Comprehensive nuclear Test ban Treaty (CTBT), CEA is developing a new generation (NG) of SPALAX™ system for atmospheric radioxenon monitoring. These systems are able to extract more than 6cm(3) of pure xenon from air samples each 12h and to measure the four relevant xenon radioactive isotopes using a high resolution detection system operating in electron-photon coincidence mode. This paper presents the performances of the SPALAX™ NG prototype in operation at Bruyères-le-Châtel CEA centre, integrating the most recent CEA developments. It especially focuses on an innovative detection system made up of a gas cell equipped with two face-to-face silicon detectors associated to one or two germanium detectors. Minimum Detectable activity Concentrations (MDCs) of environmental samples were calculated to be approximately 0.1 mBq/m(3) for the isotopes (131m)Xe, (133m)Xe, (133)Xe and 0.4 mBq/m(3) for (135)Xe (single germanium configuration). The detection system might be used to simultaneously measure particulate and noble gas samples from the CTBT International Monitoring System (IMS). That possibility could lead to new capacities for particulate measurements by allowing electron-photon coincidence detection of certain fission products. Copyright © 2015 Elsevier Ltd. All rights reserved.

40 CFR 63.2161 - What performance tests and other procedures must I use if I monitor brew ethanol?

Code of Federal Regulations, 2013 CFR

2013-07-01

... procedures must I use if I monitor brew ethanol? 63.2161 Section 63.2161 Protection of Environment... performance tests and other procedures must I use if I monitor brew ethanol? (a) You must conduct each... performance test simultaneously with brew ethanol monitoring to establish a brew-to-exhaust correlation...

40 CFR 63.2161 - What performance tests and other procedures must I use if I monitor brew ethanol?

Code of Federal Regulations, 2012 CFR

2012-07-01

... procedures must I use if I monitor brew ethanol? 63.2161 Section 63.2161 Protection of Environment... performance tests and other procedures must I use if I monitor brew ethanol? (a) You must conduct each... performance test simultaneously with brew ethanol monitoring to establish a brew-to-exhaust correlation...

40 CFR 63.2161 - What performance tests and other procedures must I use if I monitor brew ethanol?

Code of Federal Regulations, 2014 CFR

2014-07-01

... procedures must I use if I monitor brew ethanol? 63.2161 Section 63.2161 Protection of Environment... performance tests and other procedures must I use if I monitor brew ethanol? (a) You must conduct each... performance test simultaneously with brew ethanol monitoring to establish a brew-to-exhaust correlation...

Gas monitoring onboard ISS using FTIR spectroscopy

NASA Astrophysics Data System (ADS)

Gisi, Michael; Stettner, Armin; Seurig, Roland; Honne, Atle; Witt, Johannes; Rebeyre, Pierre

2017-06-01

In the confined, enclosed environment of a spacecraft, the air quality must be monitored continuously in order to safeguard the crew's health. For this reason, OHB builds the ANITA2 (Analysing Interferometer for Ambient Air) technology demonstrator for trace gas monitoring onboard the International Space Station (ISS). The measurement principle of ANITA2 is based on the Fourier Transform Infrared (FTIR) technology with dedicated gas analysis software from the Norwegian partner SINTEF. This combination proved to provide high sensitivity, accuracy and precision for parallel measurements of 33 trace gases simultaneously onboard ISS by the precursor instrument ANITA1. The paper gives a technical overview about the opto-mechanical components of ANITA2, such as the interferometer, the reference Laser, the infrared source and the gas cell design and a quick overview about the gas analysis. ANITA2 is very well suited for measuring gas concentrations specifically but not limited to usage onboard spacecraft, as no consumables are required and measurements are performed autonomously. ANITA2 is a programme under the contract of the European Space Agency, and the air quality monitoring system is a stepping stone into the future, as a precursor system for manned exploration missions.

Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps

NASA Astrophysics Data System (ADS)

Lee, Seung Yup; Pakela, Julia M.; Helton, Michael C.; Vishwanath, Karthik; Chung, Yooree G.; Kolodziejski, Noah J.; Stapels, Christopher J.; McAdams, Daniel R.; Fernandez, Daniel E.; Christian, James F.; O'Reilly, Jameson; Farkas, Dana; Ward, Brent B.; Feinberg, Stephen E.; Mycek, Mary-Ann

2017-12-01

In reconstructive surgery, the ability to detect blood flow interruptions to grafted tissue represents a critical step in preventing postsurgical complications. We have developed and pilot tested a compact, fiber-based device that combines two complimentary modalities-diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy-to quantitatively monitor blood perfusion. We present a proof-of-concept study on an in vivo porcine model (n=8). With a controllable arterial blood flow supply, occlusion studies (n=4) were performed on surgically isolated free flaps while the device simultaneously monitored blood flow through the supplying artery as well as flap perfusion from three orientations: the distal side of the flap and two transdermal channels. Further studies featuring long-term monitoring, arterial failure simulations, and venous failure simulations were performed on flaps that had undergone an anastomosis procedure (n=4). Additionally, benchtop verification of the DCS system was performed on liquid flow phantoms. Data revealed relationships between diffuse optical measures and state of occlusion as well as the ability to detect arterial and venous compromise. The compact construction of the device, along with its noninvasive and quantitative nature, would make this technology suitable for clinical translation.

A new look at deep-sea video

USGS Publications Warehouse

Chezar, H.; Lee, J.

1985-01-01

A deep-towed photographic system with completely self-contained recording instrumentation and power can obtain color-video and still-photographic transects along rough terrane without need for a long electrically conducting cable. Both the video- and still-camera systems utilize relatively inexpensive and proven off-the-shelf hardware adapted for deep-water environments. The small instrument frame makes the towed sled an ideal photographic tool for use on ship or small-boat operations. The system includes a temperature probe and altimeter that relay data acoustically from the sled to the surface ship. This relay enables the operator to monitor simultaneously water temperature and the precise height off the bottom. ?? 1985.

Enhanced Raman Monitor Project

NASA Technical Reports Server (NTRS)

Westenskow, Dwayne

1996-01-01

Monitoring of gaseous contaminants stems from the need to ensure a healthy and safe environment. NASA/Ames needs sensors that are able to monitor common atmospheric gas concentrations as well as trace amounts of contaminant gases. To provide an accurate assessment of air quality, a monitoring system would need to be continuous and on-line with full spectrum capabilities, allowing simultaneous detection of all gas components in a sample, including both combustible and non-combustible gases. The system demands a high degree of sensitivity to detect low gas concentrations in the low-ppm and sub-ppm regions. For clean and healthy air ('good' category), criteria established by the EPA requires that contaminant concentrations not exceed 4 ppm of carbon monoxide (CO) in an 8 hour period, 60 ppb of ozone(O3) in a one hour period and 30 ppb of sulfur dioxide (SO2) in a 24 hour period. One step below this is the National Ambient Air Quality Standard ('moderate' category) which requires that contaminant concentrations not exceed 9 ppm of carbon monoxide (CO), 120 ppb of ozone (O3) and 140 ppb of sulfur dioxide (SO2) for their respective time periods. Ideally a monitor should be able to detect the concentrations specified in the 'good' category. To benchmark current abilities of Raman technology in gas phase analysis, laboratory experiments were performed to evaluate the RASCAL II anesthetic gas monitor.

Simultaneous determination of phentermine and topiramate in human plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study.

PubMed

Ni, Yang; Zhou, Ying; Xu, Mingzhen; He, Xiaomeng; Li, Huqun; Haseeb, Satter; Chen, Hui; Li, Weiyong

2015-03-25

A new method for simultaneous determination of phentermine and topiramate by liquid chromatography/electrospray tandem mass spectrometry (LC/MS/MS) operated in positive and negative ionization switching modes was developed and validated. Protein precipitation with acetonitrile was selected for sample preparation. Analyses were performed on a liquid chromatography system employing a Kromasil 60-5CN column (2.1 mm × 100 mm, 5 μm) and an isocratic elution with mixed solution of acetonitrile-20mM ammonium formate containing 0.3% formic acid (40:60, v/v), at a flow rate of 0.35 mL/min. Doxazosin mesylate and pioglitazone were used as the internal standard (IS) respectively for quantification. The determination was carried out on an API 4000 triple-quadrupole mass spectrometer operated in multiple reaction monitoring (MRM) mode using the following transitions monitored simultaneously: positive m/z 150.0/91.0 for phentermine, m/z 452.1/344.3 for doxazosin, and negative m/z 338.3/77.9 for topiramate, m/z 355.0/41.9 for pioglitazone. The method was validated to be linear over the concentration range of 1-800 ng mL(-1) for phentermine, 1-1000 ng mL(-1) for topiramate. Within- and between-day accuracy and precision of the validated method at three different concentration levels were within the acceptable limits of <15% at all concentrations. Blood samples were collected into heparinized tubes before and after administration. The simple and robust LC/MS/MS method was successfully applied for the simultaneous determination of phentermine and topiramate in a pharmacokinetic study in healthy male Chinese volunteers. Copyright © 2015 Elsevier B.V. All rights reserved.

Multiple volatile organic compound vapor chamber testing with a frequency-agile CO2 DIAL system: field-test results

NASA Astrophysics Data System (ADS)

Carr, Lewis W.; Warren, Russell E.; Carlisle, Clinton B.; Carlisle, Sylvie A.; Cooper, David E.; Fletcher, Leland; Gotoff, Steven W.; Reyes, Felix

1995-02-01

Many of the 189 hazardous air pollutants (HAPs) listed in the Environmental Protection Agency regulations can be monitored by frequency agile CO2 DIAL (FACD) systems. These systems can be used to survey industrial and military installations and toxic waste repositories at ranges of a few kilometers from emission sources. FACD systems may become a valuable tool for detection and estimation of a wide array of HAPs. However, in most cases, several of the listed HAPs will be present simultaneously and discrimination of one HAP from another based on differences in spectral characteristics can be challenging for FACD systems. While FACD hardware is mature and is capable of addressing these discrimination issues, multiple-contaminate separation algorithms need to be developed. A one week field test was conducted at Los Banos, California, to gather multiple HAP data that will be used for future algorithm development. A vapor chamber was used to control disseminated concentrations of each HAP and reduce effects of atmospheric turbulence and wind direction and speed. Data was collected for several chemicals injected into the vapor chamber simultaneously. The data and results from the field test are presented and calibration issues are discussed.

Vital Sign Monitoring Through the Back Using an UWB Impulse Radar With Body Coupled Antennas.

PubMed

Schires, Elliott; Georgiou, Pantelis; Lande, Tor Sverre

2018-04-01

Radar devices can be used in nonintrusive situations to monitor vital sign, through clothes or behind walls. By detecting and extracting body motion linked to physiological activity, accurate simultaneous estimations of both heart rate (HR) and respiration rate (RR) is possible. However, most research to date has focused on front monitoring of superficial motion of the chest. In this paper, body penetration of electromagnetic (EM) wave is investigated to perform back monitoring of human subjects. Using body-coupled antennas and an ultra-wideband (UWB) pulsed radar, in-body monitoring of lungs and heart motion was achieved. An optimised location of measurement in the back of a subject is presented, to enhance signal-to-noise ratio and limit attenuation of reflected radar signals. Phase-based detection techniques are then investigated for back measurements of vital sign, in conjunction with frequency estimation methods that reduce the impact of parasite signals. Finally, an algorithm combining these techniques is presented to allow robust and real-time estimation of both HR and RR. Static and dynamic tests were conducted, and demonstrated the possibility of using this sensor in future health monitoring systems, especially in the form of a smart car seat for driver monitoring.

Sparse matrix beamforming and image reconstruction for 2-D HIFU monitoring using harmonic motion imaging for focused ultrasound (HMIFU) with in vitro validation.

PubMed

Hou, Gary Y; Provost, Jean; Grondin, Julien; Wang, Shutao; Marquet, Fabrice; Bunting, Ethan; Konofagou, Elisa E

2014-11-01

Harmonic motion imaging for focused ultrasound (HMIFU) utilizes an amplitude-modulated HIFU beam to induce a localized focal oscillatory motion simultaneously estimated. The objective of this study is to develop and show the feasibility of a novel fast beamforming algorithm for image reconstruction using GPU-based sparse-matrix operation with real-time feedback. In this study, the algorithm was implemented onto a fully integrated, clinically relevant HMIFU system. A single divergent transmit beam was used while fast beamforming was implemented using a GPU-based delay-and-sum method and a sparse-matrix operation. Axial HMI displacements were then estimated from the RF signals using a 1-D normalized cross-correlation method and streamed to a graphic user interface with frame rates up to 15 Hz, a 100-fold increase compared to conventional CPU-based processing. The real-time feedback rate does not require interrupting the HIFU treatment. Results in phantom experiments showed reproducible HMI images and monitoring of 22 in vitro HIFU treatments using the new 2-D system demonstrated reproducible displacement imaging, and monitoring of 22 in vitro HIFU treatments using the new 2-D system showed a consistent average focal displacement decrease of 46.7 ±14.6% during lesion formation. Complementary focal temperature monitoring also indicated an average rate of displacement increase and decrease with focal temperature at 0.84±1.15%/(°)C, and 2.03±0.93%/(°)C , respectively. These results reinforce the HMIFU capability of estimating and monitoring stiffness related changes in real time. Current ongoing studies include clinical translation of the presented system for monitoring of HIFU treatment for breast and pancreatic tumor applications.

Tracking the eye non-invasively: simultaneous comparison of the scleral search coil and optical tracking techniques in the macaque monkey

PubMed Central

Kimmel, Daniel L.; Mammo, Dagem; Newsome, William T.

2012-01-01

From human perception to primate neurophysiology, monitoring eye position is critical to the study of vision, attention, oculomotor control, and behavior. Two principal techniques for the precise measurement of eye position—the long-standing sclera-embedded search coil and more recent optical tracking techniques—are in use in various laboratories, but no published study compares the performance of the two methods simultaneously in the same primates. Here we compare two popular systems—a sclera-embedded search coil from C-N-C Engineering and the EyeLink 1000 optical system from SR Research—by recording simultaneously from the same eye in the macaque monkey while the animal performed a simple oculomotor task. We found broad agreement between the two systems, particularly in positional accuracy during fixation, measurement of saccade amplitude, detection of fixational saccades, and sensitivity to subtle changes in eye position from trial to trial. Nonetheless, certain discrepancies persist, particularly elevated saccade peak velocities, post-saccadic ringing, influence of luminance change on reported position, and greater sample-to-sample variation in the optical system. Our study shows that optical performance now rivals that of the search coil, rendering optical systems appropriate for many if not most applications. This finding is consequential, especially for animal subjects, because the optical systems do not require invasive surgery for implantation and repair of search coils around the eye. Our data also allow laboratories using the optical system in human subjects to assess the strengths and limitations of the technique for their own applications. PMID:22912608

Dual-channel (green and red) fluorescence microendoscope with subcellular resolution

NASA Astrophysics Data System (ADS)

de Paula D'Almeida, Camila; Fortunato, Thereza Cury; Teixeira Rosa, Ramon Gabriel; Romano, Renan Arnon; Moriyama, Lilian Tan; Pratavieira, Sebastião.

2018-02-01

Usually, tissue images at cellular level need biopsies to be done. Considering this, diagnostic devices, such as microendoscopes, have been developed with the purpose of do not be invasive. This study goal is the development of a dual-channel microendoscope, using two fluorescent labels: proflavine and protoporphyrin IX (PpIX), both approved by Food and Drug Administration. This system, with the potential to perform a microscopic diagnosis and to monitor a photodynamic therapy (PDT) session, uses a halogen lamp and an image fiber bundle to perform subcellular image. Proflavine fluorescence indicates the nuclei of the cell, which is the reference for PpIX localization on image tissue. Preliminary results indicate the efficacy of this optical technique to detect abnormal tissues and to improve the PDT dosimetry. This was the first time, up to our knowledge, that PpIX fluorescence was microscopically observed in vivo, in real time, combined to other fluorescent marker (Proflavine), which allowed to simultaneously observe the spatial localization of the PpIX in the mucosal tissue. We believe this system is very promising tool to monitor PDT in mucosa as it happens. Further experiments have to be performed in order to validate the system for PDT monitoring.

Formulation of a strategy for monitoring control integrity in critical digital control systems

NASA Technical Reports Server (NTRS)

Belcastro, Celeste M.; Fischl, Robert; Kam, Moshe

1991-01-01

Advanced aircraft will require flight critical computer systems for stability augmentation as well as guidance and control that must perform reliably in adverse, as well as nominal, operating environments. Digital system upset is a functional error mode that can occur in electromagnetically harsh environments, involves no component damage, can occur simultaneously in all channels of a redundant control computer, and is software dependent. A strategy is presented for dynamic upset detection to be used in the evaluation of critical digital controllers during the design and/or validation phases of development. Critical controllers must be able to be used in adverse environments that result from disturbances caused by an electromagnetic source such as lightning, high intensity radiated field (HIRF), and nuclear electromagnetic pulses (NEMP). The upset detection strategy presented provides dynamic monitoring of a given control computer for degraded functional integrity that can result from redundancy management errors and control command calculation error that could occur in an electromagnetically harsh operating environment. The use is discussed of Kalman filtering, data fusion, and decision theory in monitoring a given digital controller for control calculation errors, redundancy management errors, and control effectiveness.

Real time in situ ellipsometric and gravimetric monitoring for electrochemistry experiments.

PubMed

Broch, Laurent; Johann, Luc; Stein, Nicolas; Zimmer, Alexandre; Beck, Raphaël

2007-06-01

This work describes a new system using real time spectroscopic ellipsometer with simultaneous electrochemical and electrochemical quartz crystal microbalance (EQCM) measurements. This method is particularly adapted to characterize electrolyte/electrode interfaces during electrochemical and chemical processes in liquid medium. The ellipsometer, based on a rotating compensator Horiba Jobin-Yvon ellipsometer, has been adapted to acquire Psi-Delta spectra every 25 ms on a spectral range fixed from 400 to 800 nm. Measurements with short sampling times are only achievable with a fixed analyzer position (A=45 degrees ). Therefore the ellipsometer calibration is extremely important for high precision measurements and we propose a spectroscopic calibration (i.e., determination of the azimuth of elements according to the wavelength) on the whole spectral range. A homemade EQCM was developed to detect mass variations attached to the electrode. This additional instrument provides further information useful for ellipsometric data modeling of complex electrochemical systems. The EQCM measures frequency variations of piezoelectric quartz crystal oscillator working at 5 MHz. These frequency variations are linked to mass variations of electrode surface with a precision of 20 ng cm(-2) every 160 ms. Data acquisition has been developed in order to simultaneously record spectroscopic ellipsometry, EQCM, and electrochemical measurements by a single computer. Finally the electrodeposition of bismuth telluride film was monitored by this new in situ experimental setup and the density of electroplated layers was extracted from the optical thickness and EQCM mass.

Monitoring TASCC Injections Using A Field-Ready Wet Chemistry Nutrient Autoanalyzer

NASA Astrophysics Data System (ADS)

Snyder, L. E.; Herstand, M. R.; Bowden, W. B.

2011-12-01

Quantification of nutrient cycling and transport (spiraling) in stream systems is a fundamental component of stream ecology. Additions of isotopic tracer and bulk inorganic nutrient to streams have been frequently used to evaluate nutrient transfer between ecosystem compartments and nutrient uptake estimation, respectively. The Tracer Addition for Spiraling Curve Characterization (TASCC) methodology of Covino et al. (2010) instantaneously and simultaneously adds conservative and biologically active tracers to a stream system to quantify nutrient uptake metrics. In this method, comparing the ratio of mass of nutrient and conservative solute recovered in each sample throughout a breakthrough curve to that of the injectate, a distribution of spiraling metrics is calculated across a range of nutrient concentrations. This distribution across concentrations allows for both a robust estimation of ambient spiraling parameters by regression techniques, and comparison with uptake kinetic models. We tested a unique sampling strategy for TASCC injections in which samples were taken manually throughout the nutrient breakthrough curves while, simultaneously, continuously monitoring with a field-ready wet chemistry autoanalyzer. The autoanalyzer was programmed to measure concentrations of nitrate, phosphate and ammonium at the rate of one measurement per second throughout each experiment. Utilization of an autoanalyzer in the field during the experiment results in the return of several thousand additional nutrient data points when compared with manual sampling. This technique, then, allows for a deeper understanding and more statistically robust estimation of stream nutrient spiraling parameters.

The simultaneous quantitation of ten amino acids in soil extracts by mass fragmentography

NASA Technical Reports Server (NTRS)

Pereira, W. E.; Hoyano, Y.; Reynolds, W. E.; Summons, R. E.; Duffield, A. M.

1972-01-01

A specific and sensitive method for the identification and simultaneous quantitation by mass fragmentography of ten of the amino acids present in soil was developed. The technique uses a computer driven quadrupole mass spectrometer and a commercial preparation of deuterated amino acids is used as internal standards for purposes of quantitation. The results obtained are comparable with those from an amino acid analyzer. In the quadrupole mass spectrometer-computer system up to 25 pre-selected ions may be monitored sequentially. This allows a maximum of 12 different amino acids (one specific ion in each of the undeuterated and deuterated amino acid spectra) to be quantitated. The method is relatively rapid (analysis time of approximately one hour) and is capable of the quantitation of nanogram quantities of amino acids.

Fiber optic chemical sensors: The evolution of high- density fiber-optic DNA microarrays

NASA Astrophysics Data System (ADS)

Ferguson, Jane A.

2001-06-01

Sensors were developed for multianalyte monitoring, fermentation monitoring, lactate analysis, remote oxygen detection for use in bioremediation monitoring and in a fuel spill clean-up project, heavy metal analysis, and high density DNA microarrays. The major focus of this thesis involved creating and improving high-density DNA gene arrays. Fiber optic sensors are created using fluorescent indicators, polymeric supports, and optical fiber substrates. The fluorescent indicator is entrapped in a polymer layer and attached to the tip of the optical fiber. The tip of the fiber bearing the sensing layer (the distal end) is placed in the sample of interest while the other end of the fiber (the proximal end) is connected to an analysis system. Any length of fiber can be used without compromising the integrity or sensitivity of the system. A fiber optic oxygen sensor was designed incorporating an oxygen sensitive fluorescent dye and a gas permeable polymer attached to an optical fiber. The construction simplicity and ruggedness of the sensor enabled its deployment for in situ chemical oxidation and bioremediation studies. Optical fibers were also used as the substrate to detect biomolecules in solution. To monitor bioprocesses, the production of the analyte of interest must be coupled with a species that is optically measurable. For example, oxygen is consumed in many metabolic functions. The fiber optic oxygen sensor is equipped with an additional sensing layer. Upon contact with a specific biochemical in the sample, a reaction occurs in the additional sensing layer that either consumes or produces oxygen. This dual layer system was used to monitor the presence of lactate, an important metabolite for clinical and bioprocess analysis. In many biological and environmental systems, the generation of one species occurs coincidentally with the generation or consumption of another species. A multianalyte sensor was prepared that can monitor the simultaneous activity of pH, CO2 and O2. This sensor is useful for monitoring bioprocesses such as (beer) fermentation and for clinical situations such as blood gas analysis. DNA sensors were created by attaching short single strands of DNA (probes) to the fiber tip. A matching single strand (target) forms a strong interacting pair with the probe upon contact. The target strands in a sample are labeled with a fluorescent dye. When a probe-target pair is formed and excitation light is sent down the fiber, the fiber bearing the pair emits light that is captured and detected. A high density DNA array was created by isolating thousands of discrete DNA sensors on the tip of an imaging optical fiber. This array was made possible by the formation of microwells on the imaging fiber tip. Microspheres functionalized with DNA were placed in the wells of the fiber and each microsphere was independently and simultaneously monitored. (Abstract shortened by UMI.)

Verification and compensation of respiratory motion using an ultrasound imaging system.

PubMed

Chuang, Ho-Chiao; Hsu, Hsiao-Yu; Chiu, Wei-Hung; Tien, Der-Chi; Wu, Ren-Hong; Hsu, Chung-Hsien

2015-03-01

The purpose of this study was to determine if it is feasible to use ultrasound imaging as an aid for moving the treatment couch during diagnosis and treatment procedures associated with radiation therapy, in order to offset organ displacement caused by respiratory motion. A noninvasive ultrasound system was used to replace the C-arm device during diagnosis and treatment with the aims of reducing the x-ray radiation dose on the human body while simultaneously being able to monitor organ displacements. This study used a proposed respiratory compensating system combined with an ultrasound imaging system to monitor the compensation effect of respiratory motion. The accuracy of the compensation effect was verified by fluoroscopy, which means that fluoroscopy could be replaced so as to reduce unnecessary radiation dose on patients. A respiratory simulation system was used to simulate the respiratory motion of the human abdomen and a strain gauge (respiratory signal acquisition device) was used to capture the simulated respiratory signals. The target displacements could be detected by an ultrasound probe and used as a reference for adjusting the gain value of the respiratory signal used by the respiratory compensating system. This ensured that the amplitude of the respiratory compensation signal was a faithful representation of the target displacement. The results show that performing respiratory compensation with the assistance of the ultrasound images reduced the compensation error of the respiratory compensating system to 0.81-2.92 mm, both for sine-wave input signals with amplitudes of 5, 10, and 15 mm, and human respiratory signals; this represented compensation of the respiratory motion by up to 92.48%. In addition, the respiratory signals of 10 patients were captured in clinical trials, while their diaphragm displacements were observed simultaneously using ultrasound. Using the respiratory compensating system to offset, the diaphragm displacement resulted in compensation rates of 60%-84.4%. This study has shown that a respiratory compensating system combined with noninvasive ultrasound can provide real-time compensation of the respiratory motion of patients.

An integrated probe design for measuring food quality in a microwave environment

NASA Astrophysics Data System (ADS)

O'Farrell, M.; Sheridan, C.; Lewis, E.; Zhao, W. Z.; Sun, T.; Grattan, K. T. V.

2007-07-01

The work presented describes the development of a novel integrated optical sensor system for the simultaneous and online measurement of the colour and temperature of food as it cooks in a large-scale microwave and hybrid oven systems. The integrated probe contains two different sensor concepts, one to monitor temperature and based on Fibre Bragg Grating (FBG) technology and a second for meat quality, based on reflection spectroscopy in the visible wavelength range. The combination of the two sensors into a single probe requires a careful configuration of the sensor approaches in the creation of an integrated probe design.

Live single cell functional phenotyping in droplet nano-liter reactors.

PubMed

Konry, Tania; Golberg, Alexander; Yarmush, Martin

2013-11-11

While single cell heterogeneity is present in all biological systems, most studies cannot address it due to technical limitations. Here we describe a nano-liter droplet microfluidic-based approach for stimulation and monitoring of surface and secreted markers of live single immune dendritic cells (DCs) as well as monitoring the live T cell/DC interaction. This nano-liter in vivo simulating microenvironment allows delivering various stimuli reagents to each cell and appropriate gas exchanges which are necessary to ensure functionality and viability of encapsulated cells. Labeling bioassay and microsphere sensors were integrated into nano-liter reaction volume of the droplet to monitor live single cell surface markers and secretion analysis in the time-dependent fashion. Thus live cell stimulation, secretion and surface monitoring can be obtained simultaneously in distinct microenvironment, which previously was possible using complicated and multi-step in vitro and in vivo live-cell microscopy, together with immunological studies of the outcome secretion of cellular function.

The design of the m-health service application using a Nintendo DS game console.

PubMed

Lee, Sangjoon; Kim, Jungkuk; Lee, Myoungho

2011-03-01

In this article, we developed an m-health monitoring system using a Nintendo DS game console to demonstrate its utility. The proposed system consists of a biosignal acquisition device, wireless sensor network, base-station for signal reception from the sensor network and signal conversion according to Internet protocol, personal computer display program, and the Nintendo DS game console. The system collects three-channel electrocardiogram (ECG) signals for cardiac abnormality detection and three-axis accelerometer signals for fall detection of a person. The collected signals are then transmitted to the base-station through the wireless sensor network, where they are transformed according to the transmission control protocol/Internet protocol (TCP/IP) and sent to the destination IP through Internet network. To test the developed system, the collected signals were displayed on a computer located in different building through wired Internet network and also simultaneously displayed on the Nintendo DS game console connected to Internet network wirelessly. The system was able to collect and transmit signals for more than 24 h without any interruptions or malfunctions, showing the possibility of integrating healthcare monitoring functions into a small handheld-type electronic device developed for different purposes without significant complications. It is expected that the system can be used in an ambulance, nursing home, or general hospital where efficient patient monitoring from long distance is necessary.

Development of a Field-Deployable Psychomotor Vigilance Test to Monitor Helicopter Pilot Performance.

PubMed

McMahon, Terry W; Newman, David G

2016-04-01

Flying a helicopter is a complex psychomotor skill. Fatigue is a serious threat to operational safety, particularly for sustained helicopter operations involving high levels of cognitive information processing and sustained time on task. As part of ongoing research into this issue, the object of this study was to develop a field-deployable helicopter-specific psychomotor vigilance test (PVT) for the purpose of daily performance monitoring of pilots. The PVT consists of a laptop computer, a hand-operated joystick, and a set of rudder pedals. Screen-based compensatory tracking task software includes a tracking ball (operated by the joystick) which moves randomly in all directions, and a second tracking ball which moves horizontally (operated by the rudder pedals). The 5-min test requires the pilot to keep both tracking balls centered. This helicopter-specific PVT's portability and integrated data acquisition and storage system enables daily field monitoring of the performance of individual helicopter pilots. The inclusion of a simultaneous foot-operated tracking task ensures divided attention for helicopter pilots as the movement of both tracking balls requires simultaneous inputs. This PVT is quick, economical, easy to use, and specific to the operational flying task. It can be used for performance monitoring purposes, and as a general research tool for investigating the psychomotor demands of helicopter operations. While reliability and validity testing is warranted, data acquired from this test could help further our understanding of the effect of various factors (such as fatigue) on helicopter pilot performance, with the potential of contributing to helicopter operational safety.

CMS Centres Worldwide - a New Collaborative Infrastructure

NASA Astrophysics Data System (ADS)

Taylor, Lucas

2011-12-01

The CMS Experiment at the LHC has established a network of more than fifty inter-connected "CMS Centres" at CERN and in institutes in the Americas, Asia, Australasia, and Europe. These facilities are used by people doing CMS detector and computing grid operations, remote shifts, data quality monitoring and analysis, as well as education and outreach. We present the computing, software, and collaborative tools and videoconferencing systems. These include permanently running "telepresence" video links (hardware-based H.323, EVO and Vidyo), Webcasts, and generic Web tools such as CMS-TV for broadcasting live monitoring and outreach information. Being Web-based and experiment-independent, these systems could easily be extended to other organizations. We describe the experiences of using CMS Centres Worldwide in the CMS data-taking operations as well as for major media events with several hundred TV channels, radio stations, and many more press journalists simultaneously around the world.

Multimodal imaging of cutaneous wound tissue

NASA Astrophysics Data System (ADS)

Zhang, Shiwu; Gnyawali, Surya; Huang, Jiwei; Ren, Wenqi; Gordillo, Gayle; Sen, Chandan K.; Xu, Ronald

2015-01-01

Quantitative assessment of wound tissue ischemia, perfusion, and inflammation provides critical information for appropriate detection, staging, and treatment of chronic wounds. However, few methods are available for simultaneous assessment of these tissue parameters in a noninvasive and quantitative fashion. We integrated hyperspectral, laser speckle, and thermographic imaging modalities in a single-experimental setup for multimodal assessment of tissue oxygenation, perfusion, and inflammation characteristics. Algorithms were developed for appropriate coregistration between wound images acquired by different imaging modalities at different times. The multimodal wound imaging system was validated in an occlusion experiment, where oxygenation and perfusion maps of a healthy subject's upper extremity were continuously monitored during a postocclusive reactive hyperemia procedure and compared with standard measurements. The system was also tested in a clinical trial where a wound of three millimeters in diameter was introduced on a healthy subject's lower extremity and the healing process was continuously monitored. Our in vivo experiments demonstrated the clinical feasibility of multimodal cutaneous wound imaging.

Simultaneous detection of three lily viruses using Triplex IC-RT-PCR.

PubMed

Zhang, Yubao; Wang, Yajun; Xie, Zhongkui; Yang, Guo; Guo, Zhihong; Wang, Le

2017-11-01

Viruses commonly infecting lily (Lilium spp.) include: Lily symptomless virus (LSV), Cucumber mosaic virus (CMV) and Lily mottle virus (LMoV). These viruses usually co-infect lilies causing severe economic losses in terms of quantity and quality of flower and bulb production around the world. Reliable and precise detection systems need to be developed for virus identification. We describe the development of a triplex immunocapture (IC) reverse transcription (RT) polymerase chain reaction (PCR) assay for the simultaneous detection of LSV, CMV and LMoV. The triplex IC-RT-PCR was compared with a quadruplex RT-PCR assay. Relative to the quadruplex RT-PCR, the specificity of the triplex IC-RT-PCR system for LSV, CMV and LMoV was 100% for field samples. The sensitivity of the triplex IC-RT-PCR system was 99.4%, 81.4% and 98.7% for LSV, CMV and LMoV, respectively. Agreement (κ) between the results obtained from the two tests was 0.968, 0.844 and 0.984 for LSV, CMV and LMoV, respectively. This is the first report of the simultaneous detection of LSV, CMV and LMoV in a triplex IC-RT-PCR assay. In particular we believe this convenient and reliable triplex IC-RT-PCR method could be used routinely for large-scale field surveys or crop health monitoring of lily. Copyright © 2017. Published by Elsevier B.V.

Speciated Monitoring of Gas-Phase Organic Peroxy Radicals by Chemical Ionization Mass Spectrometry: Cross-Reactions between CH3O2, CH3(CO)O2, (CH3)3CO2, and c-C6H11O2.

PubMed

Nozière, Barbara; Hanson, David R

2017-11-09

Organic peroxy radicals ("RO 2 ", with R organic) are key intermediates in most oxygen-rich systems, where organic compounds are oxidized (natural environment, flames, combustion engines, living organisms, etc). But, until recently, techniques able to monitor simultaneously and distinguish between RO 2 species ("speciated" detection) have been scarce, which has limited the understanding of complex systems containing these radicals. Mass spectrometry using proton transfer ionization has been shown previously to detect individual gas-phase RO 2 separately. In this work, we illustrate its ability to speciate and monitor several RO 2 simultaneously by investigating reactions involving CH 3 O 2 , CH 3 C(O)O 2 , c-C 6 H 11 O 2 , and (CH 3 ) 3 CO 2 . The detection sensitivity of each of these radicals was estimated by titration with NO to between 50 and 1000 Hz/ppb, with a factor from 3 to 5 of uncertainties, mostly due to the uncertainties in knowing the amounts of added NO. With this, the RO 2 concentration in the reactor was estimated between 1 × 10 10 and 1 × 10 12 molecules cm -3 . When adding a second radical species to the reactor, the kinetics of the cross-reaction could be studied directly from the decay of the first radical. The time-evolution of two and sometimes three different RO 2 was followed simultaneously, as the CH 3 O 2 produced in further reaction steps was also detected in some systems. The rate coefficients obtained are (in molecule -1 cm 3 s -1 ): k CH3O2+CH3C(O)O2 = 1.2 × 10 -11 , k CH3O2+t-butylO2 = 3.0 × 10 -15 , k c-hexylO2+CH3O2 = 1.2 × 10 -13 , k t-butylO2+CH3C(O)O2 = 3.7 × 10 -14 , and k c-hexylO2+t-butylO2 = 1.5 × 10 -15 . In spite of their good comparison with the literature and good reproducibility, large uncertainties (×5/5) are recommended on these results because of those in the detection sensitivities. This work is a first illustration of the potential applications of this technique for the investigation of organic radicals in laboratory and in more complex systems.

Simultaneous neural and movement recording in large-scale immersive virtual environments.

PubMed

Snider, Joseph; Plank, Markus; Lee, Dongpyo; Poizner, Howard

2013-10-01

Virtual reality (VR) allows precise control and manipulation of rich, dynamic stimuli that, when coupled with on-line motion capture and neural monitoring, can provide a powerful means both of understanding brain behavioral relations in the high dimensional world and of assessing and treating a variety of neural disorders. Here we present a system that combines state-of-the-art, fully immersive, 3D, multi-modal VR with temporally aligned electroencephalographic (EEG) recordings. The VR system is dynamic and interactive across visual, auditory, and haptic interactions, providing sight, sound, touch, and force. Crucially, it does so with simultaneous EEG recordings while subjects actively move about a 20 × 20 ft² space. The overall end-to-end latency between real movement and its simulated movement in the VR is approximately 40 ms. Spatial precision of the various devices is on the order of millimeters. The temporal alignment with the neural recordings is accurate to within approximately 1 ms. This powerful combination of systems opens up a new window into brain-behavioral relations and a new means of assessment and rehabilitation of individuals with motor and other disorders.

Method and apparatus for simultaneously measuring temperature and pressure

DOEpatents

Hirschfeld, Tomas B.; Haugen, Gilbert R.

1988-01-01

Method and apparatus are provided for simultaneously measuring temperature and pressure in a class of crystalline materials having anisotropic thermal coefficients and having a coefficient of linear compression along the crystalline c-axis substantially the same as those perpendicular thereto. Temperature is determined by monitoring the fluorescence half life of a probe of such crystalline material, e.g., ruby. Pressure is determined by monitoring at least one other fluorescent property of the probe that depends on pressure and/or temperature, e.g., absolute fluorescent intensity or frequency shifts of fluorescent emission lines.

Validation of Contact-Free Sleep Monitoring Device with Comparison to Polysomnography

PubMed Central

Tal, Asher; Shinar, Zvika; Shaki, David; Codish, Shlomi; Goldbart, Aviv

2017-01-01

Study Objectives: To validate a contact-free system designed to achieve maximal comfort during long-term sleep monitoring, together with high monitoring accuracy. Methods: We used a contact-free monitoring system (EarlySense, Ltd., Israel), comprising an under-the-mattress piezoelectric sensor and a smartphone application, to collect vital signs and analyze sleep. Heart rate (HR), respiratory rate (RR), body movement, and calculated sleep-related parameters from the EarlySense (ES) sensor were compared to data simultaneously generated by the gold standard, polysomnography (PSG). Subjects in the sleep laboratory underwent overnight technician-attended full PSG, whereas subjects at home were recorded for 1 to 3 nights with portable partial PSG devices. Data were compared epoch by epoch. Results: A total of 63 subjects (85 nights) were recorded under a variety of sleep conditions. Compared to PSG, the contact-free system showed similar values for average total sleep time (TST), % wake, % rapid eye movement, and % non-rapid eye movement sleep, with 96.1% and 93.3% accuracy of continuous measurement of HR and RR, respectively. We found a linear correlation between TST measured by the sensor and TST determined by PSG, with a coefficient of 0.98 (R = 0.87). Epoch-by-epoch comparison with PSG in the sleep laboratory setting revealed that the system showed sleep detection sensitivity, specificity, and accuracy of 92.5%, 80.4%, and 90.5%, respectively. Conclusions: TST estimates with the contact-free sleep monitoring system were closely correlated with the gold-standard reference. This system shows good sleep staging capability with improved performance over accelerometer-based apps, and collects additional physiological information on heart rate and respiratory rate. Citation: Tal A, Shinar Z, Shaki D, Codish S, Goldbart A. Validation of contact-free sleep monitoring device with comparison to polysomnography. J Clin Sleep Med. 2017;13(3):517–522. PMID:27998378

In-situ monitoring of H2O2 degradation by live cells using voltammetric detection in a lab-on-valve system.

PubMed

Lähdesmäki, Ilkka; Park, Young K; Carroll, Andrea D; Decuir, Michael; Ruzicka, Jaromir

2007-08-01

This paper describes a method for monitoring the degradation of hydrogen peroxide by cells immobilized on a beaded support. The detection is based on the voltammetric reduction of hydrogen peroxide on a mercury film working electrode, whilst combining the concept of sequential injection (SI) with the lab-on-valve (LOV) manifold allows the measurements to be carried out in real time and automatically, in well-defined conditions. The method is shown to be capable of simultaneously monitoring hydrogen peroxide in the 10-1000 microM range and oxygen in the 160-616 microM range. A correction algorithm has been used to ensure reliable H2O2 results in the presence of varying oxygen levels. The method has been successfully applied to monitoring the degradation of H2O2 by wild-type cells and by catalase-overexpressing mouse embryonic fibroblasts. Since the technique allows the monitoring of the initial response rate, it provides data not accessible by current methods that are end-point-based measurements.

Effective monitoring of agriculture: a response.

PubMed

Sachs, Jeffrey D; Remans, Roseline; Smukler, Sean M; Winowiecki, Leigh; Andelman, Sandy J; Cassman, Kenneth G; Castle, David; DeFries, Ruth; Denning, Glenn; Fanzo, Jessica; Jackson, Louise E; Leemans, Rik; Lehmann, Johannes; Milder, Jeffrey C; Naeem, Shahid; Nziguheba, Generose; Palm, Cheryl A; Pingali, Prabhu L; Reganold, John P; Richter, Daniel D; Scherr, Sara J; Sircely, Jason; Sullivan, Clare; Tomich, Thomas P; Sanchez, Pedro A

2012-03-01

The development of effective agricultural monitoring networks is essential to track, anticipate and manage changes in the social, economic and environmental aspects of agriculture. We welcome the perspective of Lindenmayer and Likens (J. Environ. Monit., 2011, 13, 1559) as published in the Journal of Environmental Monitoring on our earlier paper, "Monitoring the World's Agriculture" (Sachs et al., Nature, 2010, 466, 558-560). In this response, we address their three main critiques labeled as 'the passive approach', 'the problem with uniform metrics' and 'the problem with composite metrics'. We expand on specific research questions at the core of the network design, on the distinction between key universal and site-specific metrics to detect change over time and across scales, and on the need for composite metrics in decision-making. We believe that simultaneously measuring indicators of the three pillars of sustainability (environmentally sound, social responsible and economically viable) in an effectively integrated monitoring system will ultimately allow scientists and land managers alike to find solutions to the most pressing problems facing global food security. This journal is © The Royal Society of Chemistry 2012

Residual gas analysis for long-pulse, advanced tokamak operation.

PubMed

Klepper, C C; Hillis, D L; Bucalossi, J; Douai, D; Oddon, P; Vartanian, S; Colas, L; Manenc, L; Pégourié, B

2010-10-01

A shielded residual gas analyzer (RGA) system on Tore Supra can function during plasma operation and is set up to monitor the composition of the neutral gas in one of the pumping ducts of the toroidal pumped limited. This "diagnostic RGA" has been used in long-pulse (up to 6 min) discharges for continuous monitoring of up to 15 masses simultaneously. Comparison of the RGA-measured evolution of the H(2)/D(2) isotopic ratio in the exhaust gas to that measured by an energetic neutral particle analyzer in the plasma core provides a way to monitor the evolution of particle balance. RGA monitoring of corrective H(2) injection to maintain proper minority heating is providing a database for improved ion cyclotron resonance heating, potentially with RGA-base feedback control. In very long pulses (>4 min) absence of significant changes in the RGA-monitored, hydrocarbon particle pressures is an indication of proper operation of the actively cooled, carbon-based plasma facing components. Also H(2) could increase due to thermodesorption of overheated plasma facing components.

Monitoring tumor metastases and osteolytic lesions with bioluminescence and micro CT imaging.

PubMed

Lim, Ed; Modi, Kshitij; Christensen, Anna; Meganck, Jeff; Oldfield, Stephen; Zhang, Ning

2011-04-14

Following intracardiac delivery of MDA-MB-231-luc-D3H2LN cells to Nu/Nu mice, systemic metastases developed in the injected animals. Bioluminescence imaging using IVIS Spectrum was employed to monitor the distribution and development of the tumor cells following the delivery procedure including DLIT reconstruction to measure the tumor signal and its location. Development of metastatic lesions to the bone tissues triggers osteolytic activity and lesions to tibia and femur were evaluated longitudinally using micro CT. Imaging was performed using a Quantum FX micro CT system with fast imaging and low X-ray dose. The low radiation dose allows multiple imaging sessions to be performed with a cumulative X-ray dosage far below LD50. A mouse imaging shuttle device was used to sequentially image the mice with both IVIS Spectrum and Quantum FX achieving accurate animal positioning in both the bioluminescence and CT images. The optical and CT data sets were co-registered in 3-dimentions using the Living Image 4.1 software. This multi-mode approach allows close monitoring of tumor growth and development simultaneously with osteolytic activity.

Web-based video monitoring of CT and MRI procedures

NASA Astrophysics Data System (ADS)

Ratib, Osman M.; Dahlbom, Magdalena; Kho, Hwa T.; Valentino, Daniel J.; McCoy, J. Michael

2000-05-01

A web-based video transmission of images from CT and MRI consoles was implemented in an Intranet environment for real- time monitoring of ongoing procedures. Images captured from the consoles are compressed to video resolution and broadcasted through a web server. When called upon, the attending radiologists can view these live images on any computer within the secured Intranet network. With adequate compression, these images can be displayed simultaneously in different locations at a rate of 2 to 5 images/sec through standard LAN. The quality of the images being insufficient for diagnostic purposes, our users survey showed that they were suitable for supervising a procedure, positioning the imaging slices and for routine quality checking before completion of a study. The system was implemented at UCLA to monitor 9 CTs and 6 MRIs distributed in 4 buildings. This system significantly improved the radiologists productivity by saving precious time spent in trips between reading rooms and examination rooms. It also improved patient throughput by reducing the waiting time for the radiologists to come to check a study before moving the patient from the scanner.

Hyperglycemia is associated with simultaneous alterations in electrical brain activity in youths with type 1 diabetes mellitus.

PubMed

Rachmiel, M; Cohen, M; Heymen, E; Lezinger, M; Inbar, D; Gilat, S; Bistritzer, T; Leshem, G; Kan-Dror, E; Lahat, E; Ekstein, D

2016-02-01

To assess the association between hyperglycemia and electrical brain activity in type 1 diabetes mellitus (T1DM). Nine youths with T1DM were monitored simultaneously and continuously by EEG and continuous glucose monitor system, for 40 h. EEG powers of 0.5-80 Hz frequency bands in all the different brain regions were analyzed according to interstitial glucose concentration (IGC) ranges of 4-11 mmol/l, 11-15.5 mmol/l and >15.5 mmol/l. Analysis of variance was used to examine the differences in EEG power of each frequency band between the subgroups of IGC. Analysis was performed separately during wakefulness and sleep, controlling for age, gender and HbA1c. Mean IGC was 11.49 ± 5.26 mmol/l in 1253 combined measurements. IGC>15.5 mmol/l compared to 4-11 mmol/l was associated during wakefulness with increased EEG power of low frequencies and with decreased EEG power of high frequencies. During sleep, it was associated with increased EEG power of low frequencies in all brain areas and of high frequencies in frontal and central areas. Asymptomatic transient hyperglycemia in youth with T1DM is associated with simultaneous alterations in electrical brain activity during wakefulness and sleep. The clinical implications of immediate electrical brain alterations under hyperglycemia need to be studied and may lead to adaptations of management. Copyright © 2015. Published by Elsevier Ireland Ltd.

A User-Configurable Headstage for Multimodality Neuromonitoring in Freely Moving Rats

PubMed Central

Limnuson, Kanokwan; Narayan, Raj K.; Chiluwal, Amrit; Golanov, Eugene V.; Bouton, Chad E.; Li, Chunyan

2016-01-01

Multimodal monitoring of brain activity, physiology, and neurochemistry is an important approach to gain insight into brain function, modulation, and pathology. With recent progress in micro- and nanotechnology, micro-nano-implants have become important catalysts in advancing brain research. However, to date, only a limited number of brain parameters have been measured simultaneously in awake animals in spite of significant recent progress in sensor technology. Here we have provided a cost and time effective approach to designing a headstage to conduct a multimodality brain monitoring in freely moving animals. To demonstrate this method, we have designed a user-configurable headstage for our micromachined multimodal neural probe. The headstage can reliably record direct-current electrocorticography (DC-ECoG), brain oxygen tension (PbrO2), cortical temperature, and regional cerebral blood flow (rCBF) simultaneously without significant signal crosstalk or movement artifacts for 72 h. Even in a noisy environment, it can record low-level neural signals with high quality. Moreover, it can easily interface with signal conditioning circuits that have high power consumption and are difficult to miniaturize. To the best of our knowledge, this is the first time where multiple physiological, biochemical, and electrophysiological cerebral variables have been simultaneously recorded from freely moving rats. We anticipate that the developed system will aid in gaining further insight into not only normal cerebral functioning but also pathophysiology of conditions such as epilepsy, stroke, and traumatic brain injury. PMID:27594826

Assessing the sensitivity of diffusion MRI to detect neuronal activity directly.

PubMed

Bai, Ruiliang; Stewart, Craig V; Plenz, Dietmar; Basser, Peter J

2016-03-22

Functional MRI (fMRI) is widely used to study brain function in the neurosciences. Unfortunately, conventional fMRI only indirectly assesses neuronal activity via hemodynamic coupling. Diffusion fMRI was proposed as a more direct and accurate fMRI method to detect neuronal activity, yet confirmative findings have proven difficult to obtain. Given that the underlying relation between tissue water diffusion changes and neuronal activity remains unclear, the rationale for using diffusion MRI to monitor neuronal activity has yet to be clearly established. Here, we studied the correlation between water diffusion and neuronal activity in vitro by simultaneous calcium fluorescence imaging and diffusion MR acquisition. We used organotypic cortical cultures from rat brains as a biological model system, in which spontaneous neuronal activity robustly emerges free of hemodynamic and other artifacts. Simultaneous fluorescent calcium images of neuronal activity are then directly correlated with diffusion MR signals now free of confounds typically encountered in vivo. Although a simultaneous increase of diffusion-weighted MR signals was observed together with the prolonged depolarization of neurons induced by pharmacological manipulations (in which cell swelling was demonstrated to play an important role), no evidence was found that diffusion MR signals directly correlate with normal spontaneous neuronal activity. These results suggest that, whereas current diffusion MR methods could monitor pathological conditions such as hyperexcitability, e.g., those seen in epilepsy, they do not appear to be sensitive or specific enough to detect or follow normal neuronal activity.

Assessing the sensitivity of diffusion MRI to detect neuronal activity directly

PubMed Central

Bai, Ruiliang; Stewart, Craig V.; Plenz, Dietmar; Basser, Peter J.

2016-01-01

Functional MRI (fMRI) is widely used to study brain function in the neurosciences. Unfortunately, conventional fMRI only indirectly assesses neuronal activity via hemodynamic coupling. Diffusion fMRI was proposed as a more direct and accurate fMRI method to detect neuronal activity, yet confirmative findings have proven difficult to obtain. Given that the underlying relation between tissue water diffusion changes and neuronal activity remains unclear, the rationale for using diffusion MRI to monitor neuronal activity has yet to be clearly established. Here, we studied the correlation between water diffusion and neuronal activity in vitro by simultaneous calcium fluorescence imaging and diffusion MR acquisition. We used organotypic cortical cultures from rat brains as a biological model system, in which spontaneous neuronal activity robustly emerges free of hemodynamic and other artifacts. Simultaneous fluorescent calcium images of neuronal activity are then directly correlated with diffusion MR signals now free of confounds typically encountered in vivo. Although a simultaneous increase of diffusion-weighted MR signals was observed together with the prolonged depolarization of neurons induced by pharmacological manipulations (in which cell swelling was demonstrated to play an important role), no evidence was found that diffusion MR signals directly correlate with normal spontaneous neuronal activity. These results suggest that, whereas current diffusion MR methods could monitor pathological conditions such as hyperexcitability, e.g., those seen in epilepsy, they do not appear to be sensitive or specific enough to detect or follow normal neuronal activity. PMID:26941239

A vision-based system for measuring the displacements of large structures: Simultaneous adaptive calibration and full motion estimation

NASA Astrophysics Data System (ADS)

Santos, C. Almeida; Costa, C. Oliveira; Batista, J.

2016-05-01

The paper describes a kinematic model-based solution to estimate simultaneously the calibration parameters of the vision system and the full-motion (6-DOF) of large civil engineering structures, namely of long deck suspension bridges, from a sequence of stereo images captured by digital cameras. Using an arbitrary number of images and assuming a smooth structure motion, an Iterated Extended Kalman Filter is used to recursively estimate the projection matrices of the cameras and the structure full-motion (displacement and rotation) over time, helping to meet the structure health monitoring fulfilment. Results related to the performance evaluation, obtained by numerical simulation and with real experiments, are reported. The real experiments were carried out in indoor and outdoor environment using a reduced structure model to impose controlled motions. In both cases, the results obtained with a minimum setup comprising only two cameras and four non-coplanar tracking points, showed a high accuracy results for on-line camera calibration and structure full motion estimation.

Simultaneous determination of five systemic azoles in plasma by high-performance liquid chromatography with ultraviolet detection.

PubMed

Gordien, Jean-Baptiste; Pigneux, Arnaud; Vigouroux, Stephane; Tabrizi, Reza; Accoceberry, Isabelle; Bernadou, Jean-Marc; Rouault, Audrey; Saux, Marie-Claude; Breilh, Dominique

2009-12-05

A simple, specific and automatable HPLC assay was developed for a simultaneous determination of systemic azoles (fluconazole, posaconazole, voriconazole, itraconazole and its metabolite hydroxyl-itraconazole, and ketoconazole) in plasma. The major advantage of this assay was sample preparation by a fully automatable solid phase extraction with Varian Plexa cartridges. C6-phenyl column was used for chromatographic separation, and UV detection was set at a wavelength of 260 nm. Linezolid was used as an internal standard. The assay was specific and linear over the concentration range of 0.05 to 40 microg/ml excepted for fluconazole which was between 0.05 and 100 microg/ml, and itraconazole between 0.1 and 40 microg/ml. Validation data for accuracy and precision for intra- and inter-day were good and satisfied FDA's guidance: CV between 0.24% and 11.66% and accuracy between 93.8% and 108.7% for all molecules. This assay was applied to therapeutic drug monitoring on patients hospitalized in intensive care and onco-hematologic units.

Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics

PubMed Central

Kim, Joohee; Kim, Minji; Lee, Mi-Sun; Kim, Kukjoo; Ji, Sangyoon; Kim, Yun-Tae; Park, Jihun; Na, Kyungmin; Bae, Kwi-Hyun; Kyun Kim, Hong; Bien, Franklin; Young Lee, Chang; Park, Jang-Ung

2017-01-01

Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses. PMID:28447604

Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics.

PubMed

Kim, Joohee; Kim, Minji; Lee, Mi-Sun; Kim, Kukjoo; Ji, Sangyoon; Kim, Yun-Tae; Park, Jihun; Na, Kyungmin; Bae, Kwi-Hyun; Kyun Kim, Hong; Bien, Franklin; Young Lee, Chang; Park, Jang-Ung

2017-04-27

Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses.

Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics

NASA Astrophysics Data System (ADS)

Kim, Joohee; Kim, Minji; Lee, Mi-Sun; Kim, Kukjoo; Ji, Sangyoon; Kim, Yun-Tae; Park, Jihun; Na, Kyungmin; Bae, Kwi-Hyun; Kyun Kim, Hong; Bien, Franklin; Young Lee, Chang; Park, Jang-Ung

2017-04-01

Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses.

In-line monitoring of Li-ion battery electrode porosity and areal loading using active thermal scanning - modeling and initial experiment

DOE PAGES

Rupnowski, Przemyslaw; Ulsh, Michael J.; Sopori, Bhushan; ...

2017-08-18

This work focuses on a new technique called active thermal scanning for in-line monitoring of porosity and areal loading of Li-ion battery electrodes. In this technique a moving battery electrode is subjected to thermal excitation and the induced temperature rise is monitored using an infra-red camera. Static and dynamic experiments with speeds up to 1.5 m min -1 are performed on both cathodes and anodes and a combined micro- and macro-scale finite element thermal model of the system is developed. It is shown experimentally and through simulations that during thermal scanning the temperature profile generated in an electrode depends onmore » both coating porosity (or area loading) and thickness. Here, it is concluded that by inverting this relation the porosity (or areal loading) can be determined, if thermal response and thickness are simultaneously measured.« less

In-line monitoring of Li-ion battery electrode porosity and areal loading using active thermal scanning - modeling and initial experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rupnowski, Przemyslaw; Ulsh, Michael J.; Sopori, Bhushan

This work focuses on a new technique called active thermal scanning for in-line monitoring of porosity and areal loading of Li-ion battery electrodes. In this technique a moving battery electrode is subjected to thermal excitation and the induced temperature rise is monitored using an infra-red camera. Static and dynamic experiments with speeds up to 1.5 m min -1 are performed on both cathodes and anodes and a combined micro- and macro-scale finite element thermal model of the system is developed. It is shown experimentally and through simulations that during thermal scanning the temperature profile generated in an electrode depends onmore » both coating porosity (or area loading) and thickness. Here, it is concluded that by inverting this relation the porosity (or areal loading) can be determined, if thermal response and thickness are simultaneously measured.« less

In-line monitoring of Li-ion battery electrode porosity and areal loading using active thermal scanning - modeling and initial experiment

NASA Astrophysics Data System (ADS)

Rupnowski, Przemyslaw; Ulsh, Michael; Sopori, Bhushan; Green, Brian G.; Wood, David L.; Li, Jianlin; Sheng, Yangping

2018-01-01

This work focuses on a new technique called active thermal scanning for in-line monitoring of porosity and areal loading of Li-ion battery electrodes. In this technique a moving battery electrode is subjected to thermal excitation and the induced temperature rise is monitored using an infra-red camera. Static and dynamic experiments with speeds up to 1.5 m min-1 are performed on both cathodes and anodes and a combined micro- and macro-scale finite element thermal model of the system is developed. It is shown experimentally and through simulations that during thermal scanning the temperature profile generated in an electrode depends on both coating porosity (or area loading) and thickness. It is concluded that by inverting this relation the porosity (or areal loading) can be determined, if thermal response and thickness are simultaneously measured.

Simultaneous monitoring the real and imaginary parts of the analyte refractive index using liquid-core photonic bandgap Bragg fibers.

PubMed

Li, Jingwen; Qu, Hang; Skorobogatiy, Maksim

2015-09-07

We demonstrate simultaneous monitoring of the real and imaginary parts of the liquid analyte refractive index by using a hollow-core Bragg fiber. We apply this two-channel fiber sensor to monitor concentrations of various commercial cooling oils. The sensor operates using spectral monitoring of the fiber bandgap center wavelength, as well as monitoring of the fiber transmission amplitude at mid-bandgap position. The sensitivity of the fiber sensor to changes in the real part of the core refractive index is found to be 1460nm/Refractive index unit (RIU). By using spectral modality and effective medium theory, we determine the concentrations of the two commercial fluids from the measured refractive indices with an accuracy of ~0.57% for both low- and high-loss oils. Moreover, using an amplitude-based detection modality allows determination of the oil concentration with accuracy of ~1.64% for low-loss oils and ~2.81% for the high-loss oils.

Development and Integration of a Solar Powered Unmanned Aerial Vehicle and a Wireless Sensor Network to Monitor Greenhouse Gases

PubMed Central

Malaver, Alexander; Motta, Nunzio; Corke, Peter; Gonzalez, Felipe

2015-01-01

Measuring gases for environmental monitoring is a demanding task that requires long periods of observation and large numbers of sensors. Wireless Sensor Networks (WSNs) and Unmanned Aerial Vehicles (UAVs) currently represent the best alternative to monitor large, remote, and difficult access areas, as these technologies have the possibility of carrying specialized gas sensing systems. This paper presents the development and integration of a WSN and an UAV powered by solar energy in order to enhance their functionality and broader their applications. A gas sensing system implementing nanostructured metal oxide (MOX) and non-dispersive infrared sensors was developed to measure concentrations of CH4 and CO2. Laboratory, bench and field testing results demonstrate the capability of UAV to capture, analyze and geo-locate a gas sample during flight operations. The field testing integrated ground sensor nodes and the UAV to measure CO2 concentration at ground and low aerial altitudes, simultaneously. Data collected during the mission was transmitted in real time to a central node for analysis and 3D mapping of the target gas. The results highlights the accomplishment of the first flight mission of a solar powered UAV equipped with a CO2 sensing system integrated with a WSN. The system provides an effective 3D monitoring and can be used in a wide range of environmental applications such as agriculture, bushfires, mining studies, zoology and botanical studies using a ubiquitous low cost technology. PMID:25679312

Development and integration of a solar powered unmanned aerial vehicle and a wireless sensor network to monitor greenhouse gases.

PubMed

Malaver, Alexander; Motta, Nunzio; Corke, Peter; Gonzalez, Felipe

2015-02-11

Measuring gases for environmental monitoring is a demanding task that requires long periods of observation and large numbers of sensors. Wireless Sensor Networks (WSNs) and Unmanned Aerial Vehicles (UAVs) currently represent the best alternative to monitor large, remote, and difficult access areas, as these technologies have the possibility of carrying specialized gas sensing systems. This paper presents the development and integration of a WSN and an UAV powered by solar energy in order to enhance their functionality and broader their applications. A gas sensing system implementing nanostructured metal oxide (MOX) and non-dispersive infrared sensors was developed to measure concentrations of CH4 and CO2. Laboratory, bench and field testing results demonstrate the capability of UAV to capture, analyze and geo-locate a gas sample during flight operations. The field testing integrated ground sensor nodes and the UAV to measure CO2 concentration at ground and low aerial altitudes, simultaneously. Data collected during the mission was transmitted in real time to a central node for analysis and 3D mapping of the target gas. The results highlights the accomplishment of the first flight mission of a solar powered UAV equipped with a CO2 sensing system integrated with a WSN. The system provides an effective 3D monitoring and can be used in a wide range of environmental applications such as agriculture, bushfires, mining studies, zoology and botanical studies using a ubiquitous low cost technology.

Field monitoring versus individual miner dosimetry of radon daughter products in mines.

PubMed

Domański, T; Kluszczyński, D; Olszewski, J; Chruscielewski, W

1989-01-01

The paper presents the results realised simultaneously by two different and independent systems of measurement of an assessment of miners' exposure to radon daughter products which naturally occur in the air of mines. The first one, called the Air Sampling System (ASS), was based on the field monitoring of radon progeny in air, the second one, called the Individual Dosimetry System (IDS), was based on the individual dosimeters worn by miners. Experimental comparison of these two systems has been conducted for six years in eleven Polish underground metal-ore mines. This study reveals that no correlation exists between the concentration and annual miners' exposures evaluated by the ASS and IDS. The ratio ASS/IDS for mine population varies from 11.0 to 0.14 in respect of annual concentration means, and in respect to annual exposures, this ratio varies from 4.5 to 0.14. The conclusion to be drawn from six years' observation and comparison of both systems is that correct and true evaluation of miners' exposure to radon progeny can be made only by the use of the Individual Dosimetry System, since the Air Sampling System is too sensitive and too dependent on the Strategy of sampling and its radiation.

Noise-Robust Monitoring of Lombard Speech Using a Wireless Neck-surface Accelerometer and Microphone

DTIC Science & Technology

2017-08-20

rechargeable, lithium - ion polymer battery that can be charged through a micro-USB input on the circuit. The micro-USB input also allows for communication to...protection, an on/off switch for the battery , status LEDs, and a logic switch that enables the `Bluetooth module to be fully functional when...simultaneously powered via USB and battery . The system contains a small receiver that is equipped with the same Bluetooth module as the transmitter (BC127

Automated mass spectrometer analysis system

NASA Technical Reports Server (NTRS)

Giffin, Charles E. (Inventor); Kuppermann, Aron (Inventor); Dreyer, William J. (Inventor); Boettger, Heinz G. (Inventor)

1982-01-01

An automated mass spectrometer analysis system is disclosed, in which samples are automatically processed in a sample processor and converted into volatilizable samples, or their characteristic volatilizable derivatives. Each volatilizable sample is sequentially volatilized and analyzed in a double focusing mass spectrometer, whose output is in the form of separate ion beams all of which are simultaneously focused in a focal plane. Each ion beam is indicative of a different sample component or different fragments of one or more sample components and the beam intensity is related to the relative abundance of the sample component. The system includes an electro-optical ion detector which automatically and simultaneously converts the ion beams, first into electron beams which in turn produce a related image which is transferred to the target of a vilicon unit. The latter converts the images into electrical signals which are supplied to a data processor, whose output is a list of the components of the analyzed sample and their abundances. The system is under the control of a master control unit, which in addition to monitoring and controlling various power sources, controls the automatic operation of the system under expected and some unexpected conditions and further protects various critical parts of the system from damage due to particularly abnormal conditions.

Automated mass spectrometer analysis system

NASA Technical Reports Server (NTRS)

Boettger, Heinz G. (Inventor); Giffin, Charles E. (Inventor); Dreyer, William J. (Inventor); Kuppermann, Aron (Inventor)

1978-01-01

An automated mass spectrometer analysis system is disclosed, in which samples are automatically processed in a sample processor and converted into volatilizable samples, or their characteristic volatilizable derivatives. Each volatizable sample is sequentially volatilized and analyzed in a double focusing mass spectrometer, whose output is in the form of separate ion beams all of which are simultaneously focused in a focal plane. Each ion beam is indicative of a different sample component or different fragments of one or more sample components and the beam intensity is related to the relative abundance of the sample component. The system includes an electro-optical ion detector which automatically and simultaneously converts the ion beams, first into electron beams which in turn produce a related image which is transferred to the target of a vidicon unit. The latter converts the images into electrical signals which are supplied to a data processor, whose output is a list of the components of the analyzed sample and their abundances. The system is under the control of a master control unit, which in addition to monitoring and controlling various power sources, controls the automatic operation of the system under expected and some unexpected conditions and further protects various critical parts of the system from damage due to particularly abnormal conditions.

Design of Dual-Road Transportable Portal Monitoring System for Visible Light and Gamma-Ray Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karnowski, Thomas Paul; Cunningham, Mark F; Goddard Jr, James Samuel

2010-01-01

The use of radiation sensors as portal monitors is increasing due to heightened concerns over the smuggling of fissile material. Transportable systems that can detect significant quantities of fissile material that might be present in vehicular traffic are of particular interest, especially if they can be rapidly deployed to different locations. To serve this application, we have constructed a rapid-deployment portal monitor that uses visible-light and gamma-ray imaging to allow simultaneous monitoring of multiple lanes of traffic from the side of a roadway. The system operation uses machine vision methods on the visible-light images to detect vehicles as they entermore » and exit the field of view and to measure their position in each frame. The visible-light and gamma-ray cameras are synchronized which allows the gamma-ray imager to harvest gamma-ray data specific to each vehicle, integrating its radiation signature for the entire time that it is in the field of view. Thus our system creates vehicle-specific radiation signatures and avoids source confusion problems that plague non-imaging approaches to the same problem. Our current prototype instrument was designed for measurement of upto five lanes of freeway traffic with a pair of instruments, one on either side of the roadway. Stereoscopic cameras are used with a third alignment camera for motion compensation and are mounted on a 50 deployable mast. In this paper we discuss the design considerations for the machine-vision system, the algorithms used for vehicle detection and position estimates, and the overall architecture of the system. We also discuss system calibration for rapid deployment. We conclude with notes on preliminary performance and deployment.« less

Design of dual-road transportable portal monitoring system for visible light and gamma-ray imaging

NASA Astrophysics Data System (ADS)

Karnowski, Thomas P.; Cunningham, Mark F.; Goddard, James S.; Cheriyadat, Anil M.; Hornback, Donald E.; Fabris, Lorenzo; Kerekes, Ryan A.; Ziock, Klaus-Peter; Bradley, E. Craig; Chesser, J.; Marchant, W.

2010-04-01

The use of radiation sensors as portal monitors is increasing due to heightened concerns over the smuggling of fissile material. Transportable systems that can detect significant quantities of fissile material that might be present in vehicular traffic are of particular interest, especially if they can be rapidly deployed to different locations. To serve this application, we have constructed a rapid-deployment portal monitor that uses visible-light and gamma-ray imaging to allow simultaneous monitoring of multiple lanes of traffic from the side of a roadway. The system operation uses machine vision methods on the visible-light images to detect vehicles as they enter and exit the field of view and to measure their position in each frame. The visible-light and gamma-ray cameras are synchronized which allows the gamma-ray imager to harvest gamma-ray data specific to each vehicle, integrating its radiation signature for the entire time that it is in the field of view. Thus our system creates vehicle-specific radiation signatures and avoids source confusion problems that plague non-imaging approaches to the same problem. Our current prototype instrument was designed for measurement of upto five lanes of freeway traffic with a pair of instruments, one on either side of the roadway. Stereoscopic cameras are used with a third "alignment" camera for motion compensation and are mounted on a 50' deployable mast. In this paper we discuss the design considerations for the machine-vision system, the algorithms used for vehicle detection and position estimates, and the overall architecture of the system. We also discuss system calibration for rapid deployment. We conclude with notes on preliminary performance and deployment.

An improved flexible telemetry system to autonomously monitor sub-bandage pressure and wound moisture.

PubMed

Mehmood, Nasir; Hariz, Alex; Templeton, Sue; Voelcker, Nicolas H

2014-11-18

This paper presents the development of an improved mobile-based telemetric dual mode sensing system to monitor pressure and moisture levels in compression bandages and dressings used for chronic wound management. The system is fabricated on a 0.2 mm thick flexible printed circuit material, and is capable of sensing pressure and moisture at two locations simultaneously within a compression bandage and wound dressing. The sensors are calibrated to sense both parameters accurately, and the data are then transmitted wirelessly to a receiver connected to a mobile device. An error-correction algorithm is developed to compensate the degradation in measurement quality due to battery power drop over time. An Android application is also implemented to automatically receive, process, and display the sensed wound parameters. The performance of the sensing system is first validated on a mannequin limb using a compression bandage and wound dressings, and then tested on a healthy volunteer to acquire real-time performance parameters. The results obtained here suggest that this dual mode sensor can perform reliably when placed on a human limb.

An Improved Flexible Telemetry System to Autonomously Monitor Sub-Bandage Pressure and Wound Moisture

PubMed Central

Mehmood, Nasir; Hariz, Alex; Templeton, Sue; Voelcker, Nicolas H.

2014-01-01

This paper presents the development of an improved mobile-based telemetric dual mode sensing system to monitor pressure and moisture levels in compression bandages and dressings used for chronic wound management. The system is fabricated on a 0.2 mm thick flexible printed circuit material, and is capable of sensing pressure and moisture at two locations simultaneously within a compression bandage and wound dressing. The sensors are calibrated to sense both parameters accurately, and the data are then transmitted wirelessly to a receiver connected to a mobile device. An error-correction algorithm is developed to compensate the degradation in measurement quality due to battery power drop over time. An Android application is also implemented to automatically receive, process, and display the sensed wound parameters. The performance of the sensing system is first validated on a mannequin limb using a compression bandage and wound dressings, and then tested on a healthy volunteer to acquire real-time performance parameters. The results obtained here suggest that this dual mode sensor can perform reliably when placed on a human limb. PMID:25412216

Using SFOC to fly the Magellan Venus mapping mission

NASA Technical Reports Server (NTRS)

Bucher, Allen W.; Leonard, Robert E., Jr.; Short, Owen G.

1993-01-01

Traditionally, spacecraft flight operations at the Jet Propulsion Laboratory (JPL) have been performed by teams of spacecraft experts utilizing ground software designed specifically for the current mission. The Jet Propulsion Laboratory set out to reduce the cost of spacecraft mission operations by designing ground data processing software that could be used by multiple spacecraft missions, either sequentially or concurrently. The Space Flight Operations Center (SFOC) System was developed to provide the ground data system capabilities needed to monitor several spacecraft simultaneously and provide enough flexibility to meet the specific needs of individual projects. The Magellan Spacecraft Team utilizes the SFOC hardware and software designed for engineering telemetry analysis, both real-time and non-real-time. The flexibility of the SFOC System has allowed the spacecraft team to integrate their own tools with SFOC tools to perform the tasks required to operate a spacecraft mission. This paper describes how the Magellan Spacecraft Team is utilizing the SFOC System in conjunction with their own software tools to perform the required tasks of spacecraft event monitoring as well as engineering data analysis and trending.

Multisensor Capacitance Probes for Simultaneously Monitoring Rice Field Soil-Water- Crop-Ambient Conditions.

PubMed

Brinkhoff, James; Hornbuckle, John; Dowling, Thomas

2017-12-26

Multisensor capacitance probes (MCPs) have traditionally been used for soil moisture monitoring and irrigation scheduling. This paper presents a new application of these probes, namely the simultaneous monitoring of ponded water level, soil moisture, and temperature profile, conditions which are particularly important for rice crops in temperate growing regions and for rice grown with prolonged periods of drying. WiFi-based loggers are used to concurrently collect the data from the MCPs and ultrasonic distance sensors (giving an independent reading of water depth). Models are fit to MCP water depth vs volumetric water content (VWC) characteristics from laboratory measurements, variability from probe-to-probe is assessed, and the methodology is verified using measurements from a rice field throughout a growing season. The root-mean-squared error of the water depth calculated from MCP VWC over the rice growing season was 6.6 mm. MCPs are used to simultaneously monitor ponded water depth, soil moisture content when ponded water is drained, and temperatures in root, water, crop and ambient zones. The insulation effect of ponded water against cold-temperature effects is demonstrated with low and high water levels. The developed approach offers advantages in gaining the full soil-plant-atmosphere continuum in a single robust sensor.

Simultaneous life extension and crack monitoring of fatigue-damaged steel members using multifunctional carbon nanotube based composites

NASA Astrophysics Data System (ADS)

Ahmed, Shafique; Schumacher, Thomas; Thostenson, Erik T.; McConnell, Jennifer

2017-04-01

Steel structures including bridges are susceptible to cracking, particularly due to fatigue-sensitive details found in older designs. Therefore, one of the major challenges to keep those steel bridges in service is to rehabilitate existing and potential fatigue damage. There are several conventional approaches to extend the fatigue-life of damaged steel members, e.g., drilling a crack stop-hole to reduce the stress concentration at the crack tip as well as welding and bolting of steel plates or adhesive-bonding of fiber-reinforced polymers (FRP) to reduce the overall stresses. Improvement in material properties of FRP and adhesives make them a viable candidate to apply for extending the fatigue-life of steel members. However, drawbacks include the potential for debonding of the adhesive layer and/or interfaces between adhesive and adherents as well as difficulty in monitoring fatigue crack growth after rehabilitation. In this research, a holistic approach is proposed and evaluated for simultaneous extension of fatigue-life and monitoring by integrating a carbon nanotube (CNT)-based sensing layer with an adhesively-bonded FRP reinforcement. CNT-based sensing layers have a nerve-like electric resistance network, which enables distributed sensing capabilities to monitor stress levels, crack growth, and damage progression. Using laboratory-scale experiments, the simultaneous fatigue-life extension and crack monitoring capability of multifunctional CNT-based composites was evaluated. This paper introduces the fundamental concept of integrated fatigue-rehabilitation and monitoring of steel members, presents a laboratory-scale experiment to demonstrate the feasibility and effectiveness, and discusses challenges for implementation in real structures.

Quantitative monitoring of two simultaneously binding species using Label-Enhanced surface plasmon resonance.

PubMed

Eng, Lars; Garcia, Brandon L; Geisbrecht, Brian V; Hanning, Anders

2018-02-26

Surface plasmon resonance (SPR) is a well-established method for biomolecular interaction studies. SPR monitors the binding of molecules to a solid surface, embodied as refractive index changes close to the surface. One limitation of conventional SPR is the universal nature of the detection that results in an inability to qualitatively discriminate between different binding species. Furthermore, it is impossible to directly discriminate two species simultaneously binding to different sites on a protein, which limits the utility of SPR, for example, in the study of allosteric binders or bi-specific molecules. It is also impossible in principle to discriminate protein conformation changes from actual binding events. Here we demonstrate how Label-Enhanced SPR can be utilized to discriminate and quantitatively monitor the simultaneous binding of two different species - one dye-labeled and one unlabeled - on a standard, single-wavelength SPR instrument. This new technique increases the versatility of SPR technology by opening up application areas where the usefulness of the approach has previously been limited. Copyright © 2018 Elsevier Inc. All rights reserved.

Surveying the Sky at Low Frequencies with the Commensal VLITE System

NASA Astrophysics Data System (ADS)

Clarke, Tracy; Kassim, Namir E.; Richards, Emily; Peters, Wendy; Polisensky, Emil

2017-05-01

We present details of a new commensal observing program on NRAO's Karl G. Jansky Very Large Array (VLA). The VLA Low-band Ionosphere and Transient Experiment (VLITE) provides a simultaneous sub-GHz data stream during all Cassegrain (1-50 GHz) observations. This unique low frequency opportunity opens up over 6000 hours per year of VLA observing time to the low frequency community. In the first 2 1/4 years of operation, VLITE processed images cover regions containing 2,322 unique exoplanets in 62,000 individual scans. VLITE observations provide a large database to observe samples of nearby stellar systems, enabling a powerful means of monitoring these systems for stellar activity as well as emission from exoplanets.

Titration of Alanine Monitored by NMR Spectroscopy: A Biochemistry Laboratory Experiment

ERIC Educational Resources Information Center

Waller, Francis J.; And Others

1977-01-01

The experiment described here involves simultaneous monitoring of pH and NMR chemical shifts during an aqueous titration of alpha- and beta-alanine. This experiment is designed for use in an undergraduate biochemistry course. (MR)

Hybrid System for Ex Vivo Hemorheological and Hemodynamic Analysis: A Feasibility Study

PubMed Central

Yeom, Eunseop; Jun Kang, Yang; Joon Lee, Sang

2015-01-01

Precise measurement of biophysical properties is important to understand the relation between these properties and the outbreak of cardiovascular diseases (CVDs). However, a systematic measurement for these biophysical parameters under in vivo conditions is nearly impossible because of complex vessel shape and limited practicality. In vitro measurements can provide more biophysical information, but in vitro exposure changes hemorheological properties. In this study, a hybrid system composed of an ultrasound system and microfluidic device is proposed for monitoring hemorheological and hemodynamic properties under more reasonable experimental conditions. Biophysical properties including RBC aggregation, viscosity, velocity, and pressure of blood flows are simultaneously measured under various conditions to demonstrate the feasibility and performance of this measurement system. The proposed technique is applied to a rat extracorporeal loop which connects the aorta and jugular vein directly. As a result, the proposed system is found to measure biophysical parameters reasonably without blood collection from the rat and provided more detailed information. This hybrid system, combining ultrasound imaging and microfluidic techniques to ex vivo animal models, would be useful for monitoring the variations of biophysical properties induced by chemical agents. It can be used to understand the relation between biophysical parameters and CVDs. PMID:26090816

Imaging a photodynamic therapy photosensitizer in vivo with a time-gated fluorescence tomography system

NASA Astrophysics Data System (ADS)

Mo, Weirong; Rohrbach, Daniel; Sunar, Ulas

2012-07-01

We report the tomographic imaging of a photodynamic therapy (PDT) photosensitizer, 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) in vivo with time-domain fluorescence diffuse optical tomography (TD-FDOT). Simultaneous reconstruction of fluorescence yield and lifetime of HPPH was performed before and after PDT. The methodology was validated in phantom experiments, and depth-resolved in vivo imaging was achieved through simultaneous three-dimensional (3-D) mappings of fluorescence yield and lifetime contrasts. The tomographic images of a human head-and-neck xenograft in a mouse confirmed the preferential uptake and retention of HPPH by the tumor 24-h post-injection. HPPH-mediated PDT induced significant changes in fluorescence yield and lifetime. This pilot study demonstrates that TD-FDOT may be a good imaging modality for assessing photosensitizer distributions in deep tissue during PDT monitoring.

Spectrally Resolved Fiber Photometry for Multi-component Analysis of Brain Circuits.

PubMed

Meng, Chengbo; Zhou, Jingheng; Papaneri, Amy; Peddada, Teja; Xu, Karen; Cui, Guohong

2018-04-25

To achieve simultaneous measurement of multiple cellular events in molecularly defined groups of neurons in vivo, we designed a spectrometer-based fiber photometry system that allows for spectral unmixing of multiple fluorescence signals recorded from deep brain structures in behaving animals. Using green and red Ca 2+ indicators differentially expressed in striatal direct- and indirect-pathway neurons, we were able to simultaneously monitor the neural activity in these two pathways in freely moving animals. We found that the activities were highly synchronized between the direct and indirect pathways within one hemisphere and were desynchronized between the two hemispheres. We further analyzed the relationship between the movement patterns and the magnitude of activation in direct- and indirect-pathway neurons and found that the striatal direct and indirect pathways coordinately control the dynamics and fate of movement. Published by Elsevier Inc.

Simultaneous Monitoring of Ballistocardiogram and Photoplethysmogram Using Camera

PubMed Central

Shao, Dangdang; Tsow, Francis; Liu, Chenbin; Yang, Yuting; Tao, Nongjian

2017-01-01

We present a noncontact method to measure Ballistocardiogram (BCG) and Photoplethysmogram (PPG) simultaneously using a single camera. The method tracks the motion of facial features to determine displacement BCG, and extracts the corresponding velocity and acceleration BCGs by taking first and second temporal derivatives from the displacement BCG, respectively. The measured BCG waveforms are consistent with those reported in literature and also with those recorded with an accelerometer-based reference method. The method also tracks PPG based on the reflected light from the same facial region, which makes it possible to track both BCG and PPG with the same optics. We verify the robustness and reproducibility of the noncontact method with a small pilot study with 23 subjects. The presented method is the first demonstration of simultaneous BCG and PPG monitoring without wearing any extra equipment or marker by the subject. PMID:27362754

Design of laser monitoring and sound localization system

NASA Astrophysics Data System (ADS)

Liu, Yu-long; Xu, Xi-ping; Dai, Yu-ming; Qiao, Yang

2013-08-01

In this paper, a novel design of laser monitoring and sound localization system is proposed. It utilizes laser to monitor and locate the position of the indoor conversation. In China most of the laser monitors no matter used in labor in an instrument uses photodiode or phototransistor as a detector at present. At the laser receivers of those facilities, light beams are adjusted to ensure that only part of the window in photodiodes or phototransistors received the beams. The reflection would deviate from its original path because of the vibration of the detected window, which would cause the changing of imaging spots in photodiode or phototransistor. However, such method is limited not only because it could bring in much stray light in receivers but also merely single output of photocurrent could be obtained. Therefore a new method based on quadrant detector is proposed. It utilizes the relation of the optical integral among quadrants to locate the position of imaging spots. This method could eliminate background disturbance and acquired two-dimensional spots vibrating data pacifically. The principle of this whole system could be described as follows. Collimated laser beams are reflected from vibrate-window caused by the vibration of sound source. Therefore reflected beams are modulated by vibration source. Such optical signals are collected by quadrant detectors and then are processed by photoelectric converters and corresponding circuits. Speech signals are eventually reconstructed. In addition, sound source localization is implemented by the means of detecting three different reflected light sources simultaneously. Indoor mathematical models based on the principle of Time Difference Of Arrival (TDOA) are established to calculate the twodimensional coordinate of sound source. Experiments showed that this system is able to monitor the indoor sound source beyond 15 meters with a high quality of speech reconstruction and to locate the sound source position accurately.

Simultaneous chromatic dispersion monitoring and optical modulation format identification utilizing four wave mixing

NASA Astrophysics Data System (ADS)

Cui, Sheng; Qiu, Chen; Ke, Changjian; He, Sheng; Liu, Deming

2015-11-01

This paper presents a method which is able to monitor the chromatic dispersion (CD) and identify the modulation format (MF) of optical signals simultaneously. This method utilizes the features of the output curve of the highly sensitive all-optical CD monitor based on four wave mixing (FWM). From the symmetric center of the curve CD can be estimated blindly and independently, while from the profile and convergence region of the curve ten commonly used modulation formats can be recognized with simple algorithm based on maximum correlation classifier. This technique does not need any high speed optoelectronics and has no limitation on signal rate. Furthermore it can tolerate large CD distortions and is robust to polarization mode dispersion (PMD) and amplified spontaneous emission (ASE) noise.

Simultaneous long-term monitoring of LS I +61°303 by OVRO and Fermi-LAT

NASA Astrophysics Data System (ADS)

Jaron, Frédéric; Massi, Maria; Kiehlmann, Sebastian; Hovatta, Talvikki

2018-07-01

Previous long-term monitorings of the γ-ray-loud X-ray binary LS I +61°303 have revealed the presence of a long-term modulation of ˜4.5 yr. After 9 yr of simultaneous monitoring of LS I +61°303 by the Owens Valley Radio Observatory and the Fermi-LAT, two cycles of the long-term period are now available. Here we perform timing analysis on the radio and the γ-ray light curves. We confirm the presence of previously detected periodicities at both radio and GeV γ-ray wavelengths. Moreover, we discover an offset of the long-term modulation between radio and γ-ray data which could imply different locations of the radio (15 GHz) and GeV emission along the precessing jet.

Brain physiological state evaluated by real-time multiparametric tissue spectroscopy in vivo

NASA Astrophysics Data System (ADS)

Mayevsky, Avraham; Barbiro-Michaely, Efrat; Kutai-Asis, Hofit; Deutsch, Assaf; Jaronkin, Alex

2004-07-01

The significance of normal mitochondrial function in cellular energy homeostasis as well as its involvement in acute and chronic neurodegenerative disease was reviewed recently (Nicholls & Budd. Physiol Rev. 80: 315-360, 2000). Nevertheless, monitoring of mitochondrial function in vivo and real time mode was not used by many investigators and is very rare in clinical practice. The main principle tool available for the evaluation of mitochondrial function is the monitoring of NADH fluorescence. In order to interpret correctly the changes in NADH redox state in vivo, it is necessary to correlate this signal to other parameters, reflecting O2 supply to the brain. Therefore, we have developed and applied a multiparametric optical monitoring system, by which microcirculatory blood flow and hemoglobin oxygenation is measured, together with mitochondrial NADH fluorescence. Since the calibration of these signals is not in absolute units, the simultaneous monitoring provide a practical tool for the interpretation of brain functional state under various pathophysiological conditions. The monitoring system combines a time-sharing fluorometer-reflectometer for the measurement of NADH fluorescence and hemoglobin oxygenation as well as a laser Doppler flowmeter for the recording of microcirculatory blood flow. A combined fiber optic probe was located on the surface of the brain using a skull cemented cannula. Rats and gerbils were exposed to anoxia, ischemia and spreading depression and the functional state of the brain was evaluated. The results showed a clear correlation between O2 supply/demand as well as, energy balance under the various pathophysiological conditions. This monitoring approach could be adapted to clinical monitoring of tissue vitality.

Analyzing near infrared scattering from human skin to monitor changes in hematocrit

NASA Astrophysics Data System (ADS)

Chaiken, Joseph; Deng, Bin; Goodisman, Jerry; Shaheen, George; Bussjager, R. J.

2012-01-01

The leading preventable cause of death, world-wide, civilian or military, for all people between the ages of 18-45 is undetected internal hemorrhage. Autonomic compensation mechanisms mask changes such as e.g. hematocrit fluctuations that could give early warning if only they could be monitored continuously with reasonable degrees of precision and relative accuracy. Probing tissue with near infrared radiation (NIR) simultaneously produces remitted fluorescence and Raman scattering (IE) plus Rayleigh/Mie light scattering (EE) that noninvasively give chemical and physical information about the materials and objects within. We model tissue as a three-phase system: plasma and red blood cell (RBC) phases that are mobile and a static tissue phase. In vivo, any volume of tissue naturally experiences spatial and temporal fluctuations of blood plasma and RBC content. Plasma and RBC fractions may be discriminated from each other on the basis of their physical, chemical and optical properties. Thus IE and EE from NIR probing yield information about these fractions. Assuming there is no void volume in viable tissue, or that void volume is constant, changes in plasma and RBC volume fractions may be calculated from simultaneous measurements of the two observables, EE and IE. In a previously published analysis we showed the underlying phenomenology but did not provide an algorithm for calculating volume fractions from experimental data. Here we present a simple analysis that allows continuous monitoring of fluid fraction and hematocrit (Hct) changes by measuring IE and EE, and apply it to some experimental in vivo measurements.

Spectral-decomposition techniques for the identification of radon anomalies temporally associated with earthquakes occurring in the UK in 2002 and 2008.

NASA Astrophysics Data System (ADS)

Crockett, R. G. M.; Gillmore, G. K.

2009-04-01

During the second half of 2002, the University of Northampton Radon Research Group operated two continuous hourly-sampling radon detectors 2.25 km apart in Northampton, in the (English) East Midlands. This period included the Dudley earthquake (22/09/2002) which was widely noticed by members of the public in the Northampton area. Also, at various periods during 2008 the Group has operated another pair of continuous hourly-sampling radon detectors similar distances apart in Northampton. One such period included the Market Rasen earthquake (27/02/2008) which was also widely noticed by members of the public in the Northampton area. During each period of monitoring, two time-series of radon readings were obtained, one from each detector. These have been analysed for evidence of simultaneous similar anomalies: the premise being that big disturbances occurring at big distances (in relation to the detector separation) should produce simultaneous similar anomalies but that simultaneous anomalies occurring by chance will be dissimilar. As previously reported, cross-correlating the two 2002 time-series over periods of 1-30 days duration, rolled forwards through the time-series at one-hour intervals produced two periods of significant correlation, i.e. two periods of simultaneous similar behaviour in the radon concentrations. One of these periods corresponded in time to the Dudley earthquake, the other corresponded in time to a smaller earthquake which occurred in the English Channel (26/08/2002). We here report subsequent investigation of the 2002 time-series and the 2008 time-series using spectral-decomposition techniques. These techniques have revealed additional simultaneous similar behaviour in the two radon concentrations, not revealed by the rolling correlation on the raw data. These correspond in time to the Manchester earthquake swarm of October 2002 and the Market Rasen earthquake of February 2008. The spectral-decomposition techniques effectively ‘de-noise' the data, and also remove lower-frequency variations (e.g. tidal variations), revealing the simultaneous similarities. Whilst this is very much work in progress, there is the potential that such techniques enhance the possibility that simultaneous real-time monitoring of radon levels - for short-term simultaneous anomalies - at several locations in earthquake areas might provide the core of an earthquake prediction method. Keywords: Radon; earthquakes; time series; cross-correlation; spectral-decomposition; real-time simultaneous monitoring.

[A skin cell segregating control system based on PC].

PubMed

Liu, Wen-zhong; Zhou, Ming; Zhang, Hong-bing

2005-11-01

A skin cell segregating control system based on PC (personal computer) is presented in this paper. Its front controller is a single-chip microcomputer which enables the manipulation for 6 patients simultaneously, and thus provides a great convenience for clinical treatments for vitiligo. With the use of serial port communication technology, it's possible to monitor and control the front controller in a PC terminal. And the application of computer image acquisition technology realizes the synchronous acquisition of pathologic shin cell images pre/after the operation and a case history. Clinical tests prove its conformity with national standards and the pre-set technological requirements.

Parallel separations using capillary electrophoresis on a multilane microchip with multiplexed laser-induced fluorescence detection.

PubMed

Nikcevic, Irena; Piruska, Aigars; Wehmeyer, Kenneth R; Seliskar, Carl J; Limbach, Patrick A; Heineman, William R

2010-08-01

Parallel separations using CE on a multilane microchip with multiplexed LIF detection is demonstrated. The detection system was developed to simultaneously record data on all channels using an expanded laser beam for excitation, a camera lens to capture emission, and a CCD camera for detection. The detection system enables monitoring of each channel continuously and distinguishing individual lanes without significant crosstalk between adjacent lanes. Multiple analytes can be determined in parallel lanes within a single microchip in a single run, leading to increased sample throughput. The pK(a) determination of small molecule analytes is demonstrated with the multilane microchip.

Parallel separations using capillary electrophoresis on a multilane microchip with multiplexed laser induced fluorescence detection

PubMed Central

Nikcevic, Irena; Piruska, Aigars; Wehmeyer, Kenneth R.; Seliskar, Carl J.; Limbach, Patrick A.; Heineman, William R.

2010-01-01

Parallel separations using capillary electrophoresis on a multilane microchip with multiplexed laser induced fluorescence detection is demonstrated. The detection system was developed to simultaneously record data on all channels using an expanded laser beam for excitation, a camera lens to capture emission, and a CCD camera for detection. The detection system enables monitoring of each channel continuously and distinguishing individual lanes without significant crosstalk between adjacent lanes. Multiple analytes can be analyzed on parallel lanes within a single microchip in a single run, leading to increased sample throughput. The pKa determination of small molecule analytes is demonstrated with the multilane microchip. PMID:20737446

A dual modality optical fiber sensor

NASA Astrophysics Data System (ADS)

Herrera-Piad, Luis A.; Haus, Joseph W.; Jauregui-Vazquez, Daniel; Lopez-Dieguez, Yanelis; Estudillo-Ayala, Julian M.; Sierra-Hernandez, Juan M.; Hernandez-Garcia, Juan C.; Rojas-Laguna, Roberto

2018-02-01

We propose and demonstrate a fibre optic system based on bi-tapered silica fibre that can simultaneously measure strain and fibre curvature. Both modalities on the signal can be extracted with no measurable crosstalk between them. The experimental signal has a pure phase modulation when strain is applied to the tapered fibre optic section of the sensor and the signal shows only intensity modulation when an un-tapered fibre section is bent. High sensitivity is achieved from the experimental results for strain and bending losses and the estimation of measurement errors is 0.2 and 0.1%, respectively. This system offers low-cost, compactness and it can be adapted for structural health monitoring.

[Efficiency of medical and economic activities of a sanatorium-and-spa facility in the active phase of the public health system reform under macroeconomic instability].

PubMed

Poliakov, B A; Kizeev, M V

2010-01-01

Results of a comprehensive study have demonstrated that the reform of the public health system currently underway in this country provides conditions for the extension of medical care based at sanatorium-and-spa facilities with simultaneous rise in relevant expenses. Bearing in mind the unstable macroeconomic situation, this requires thorough monitoring medical and economic activities of health resorts for the purpose of enhancing cost efficiency. The goal of optimization can be achieved by increasing competitive capacity based on strict control of expenditures and income redistribution for financing the most promising projects.

Bioelectric Signal Measuring System

NASA Astrophysics Data System (ADS)

Guadarrama-Santana, A.; Pólo-Parada, L.; García-Valenzuela, A.

2015-01-01

We describe a low noise measuring system based on interdigitated electrodes for sensing bioelectrical signals. The system registers differential voltage measurements in order of microvolts. The base noise during measurements was in nanovolts and thus, the sensing signals presented a very good signal to noise ratio. An excitation voltage of 1Vrms with 10 KHz frequency was applied to an interdigitated capacitive sensor without a material under test and to a mirror device simultaneously. The output signals of both devices was then subtracted in order to obtain an initial reference value near cero volts and reduce parasitic capacitances due to the electronics, wiring and system hardware as well. The response of the measuring system was characterized by monitoring temporal bioelectrical signals in real time of biological materials such as embryo chicken heart cells and bovine suprarenal gland cells.

Evaluation of an airborne triple-pulsed 2 μm IPDA lidar for simultaneous and independent atmospheric water vapor and carbon dioxide measurements.

PubMed

Refaat, Tamer F; Singh, Upendra N; Yu, Jirong; Petros, Mulugeta; Ismail, Syed; Kavaya, Michael J; Davis, Kenneth J

2015-02-20

Water vapor and carbon dioxide are the most dominant greenhouse gases directly contributing to the Earth's radiation budget and global warming. A performance evaluation of an airborne triple-pulsed integrated path differential absorption (IPDA) lidar system for simultaneous and independent monitoring of atmospheric water vapor and carbon dioxide column amounts is presented. This system leverages a state-of-the-art Ho:Tm:YLF triple-pulse laser transmitter operating at 2.05 μm wavelength. The transmitter provides wavelength tuning and locking capabilities for each pulse. The IPDA lidar system leverages a low risk and technologically mature receiver system based on InGaAs pin detectors. Measurement methodology and wavelength setting are discussed. The IPDA lidar return signals and error budget are analyzed for airborne operation on-board the NASA B-200. Results indicate that the IPDA lidar system is capable of measuring water vapor and carbon dioxide differential optical depth with 0.5% and 0.2% accuracy, respectively, from an altitude of 8 km to the surface and with 10 s averaging. Provided availability of meteorological data, in terms of temperature, pressure, and relative humidity vertical profiles, the differential optical depth conversion into weighted-average column dry-air volume-mixing ratio is also presented.

Cerebral venous blood oxygenation monitoring during hyperventilation in healthy volunteers with a novel optoacoustic system

NASA Astrophysics Data System (ADS)

Petrov, Andrey; Prough, Donald S.; Petrov, Irene Y.; Petrov, Yuriy; Deyo, Donald J.; Henkel, Sheryl N.; Seeton, Roger; Esenaliev, Rinat O.

2013-03-01

Monitoring of cerebral venous oxygenation is useful to facilitate management of patients with severe or moderate traumatic brain injury (TBI). Prompt recognition of low cerebral venous oxygenation is a key to avoiding secondary brain injury associated with brain hypoxia. In specialized clinical research centers, jugular venous bulb catheters have been used for cerebral venous oxygenation monitoring and have demonstrated that oxygen saturation < 50% (normal range is 55-75%) correlates with poor clinical outcome. We developed an optoacoustic technique for noninvasive monitoring of cerebral venous oxygenation. Recently, we designed and built a novel, medical grade optoacoustic system operating in the near-infrared spectral range for continuous, real-time oxygenation monitoring in the superior sagittal sinus (SSS), a large central cerebral vein. In this work, we designed and built a novel SSS optoacoustic probe and developed a new algorithm for SSS oxygenation measurement. The SSS signals were measured in healthy volunteers during voluntary hyperventilation, which induced changes in SSS oxygenation. Simultaneously, we measured exhaled carbon dioxide concentration (EtCO2) using capnography. Good temporal correlation between decreases in optoacoustically measured SSS oxygenation and decreases in EtCO2 was obtained. Decreases in EtCO2 from normal values (35-45 mmHg) to 20-25 mmHg resulted in SSS oxygenation decreases by 3-10%. Intersubject variability of the responses may relate to nonspecific brain activation associated with voluntary hyperventilation. The obtained data demonstrate the capability of the optoacoustic system to detect in real time minor changes in the SSS blood oxygenation.

Small diameter, deep bore optical inspection system

DOEpatents

Lord, David E.; Petrini, Richard R.; Carter, Gary W.

1981-01-01

An improved rod optic system for inspecting small diameter, deep bores. The system consists of a rod optic system utilizing a curved mirror at the end of the rod lens such that the optical path through the system is bent 90.degree. to minimize optical distortion in examining the sides of a curved bore. The system is particularly useful in the examination of small bores for corrosion, and is capable of examining 1/16 inch diameter and up to 4 inch deep drill holes, for example. The positioning of the curved mirror allows simultaneous viewing from shallow and right angle points of observation of the same artifact (such as corrosion) in the bore hole. The improved rod optic system may be used for direct eye sighting, or in combination with a still camera or a low-light television monitor; particularly low-light color television.

Multi-detector system approach for unattended uranium enrichment monitoring at gas centrifuge enrichment plants

NASA Astrophysics Data System (ADS)

Favalli, A.; Lombardi, M.; MacArthur, D. W.; McCluskey, C.; Moss, C. E.; Paffett, M. T.; Ianakiev, K. D.

2018-01-01

Improving the quality of safeguards measurements at Gas Centrifuge Enrichment Plants while reducing the inspection effort is an important objective given the number of existing and new plants that need to be safeguarded. A useful tool in many safeguards approaches is the on-line monitoring of enrichment in process pipes. One requirement of such a monitor is a simple, reliable and precise passive measurement of the 186-keV line from 235U. The other information required is the amount of gas in the pipe, which can be obtained by a transmission or pressure measurement. We describe our research to develop such a passive measurement system. Unfortunately, a complication arises in the interpretation of the gamma measurements, from the contribution of uranium deposits on the wall of the pipe to the 186-keV peak. A multi-detector approach to address this complication is presented where two measurements, one with signal primarily from gas and one with signal primarily from deposits, are performed simultaneously with different detectors and geometries. This allows a correction to be made to the 186-keV peak for the contribution from the deposit. We present the design of the multi-detector system and the results of the experimental calibration of the proof-of-principle prototype built at LANL.

Application of Terrestrial Microwave Remote Sensing to Agricultural Drought Monitoring

NASA Astrophysics Data System (ADS)

Crow, W. T.; Bolten, J. D.

2014-12-01

Root-zone soil moisture information is a valuable diagnostic for detecting the onset and severity of agricultural drought. Current attempts to globally monitor root-zone soil moisture are generally based on the application of soil water balance models driven by observed meteorological variables. Such systems, however, are prone to random error associated with: incorrect process model physics, poor parameter choices and noisy meteorological inputs. The presentation will describe attempts to remediate these sources of error via the assimilation of remotely-sensed surface soil moisture retrievals from satellite-based passive microwave sensors into a global soil water balance model. Results demonstrate the ability of satellite-based soil moisture retrieval products to significantly improve the global characterization of root-zone soil moisture - particularly in data-poor regions lacking adequate ground-based rain gage instrumentation. This success has lead to an on-going effort to implement an operational land data assimilation system at the United States Department of Agriculture's Foreign Agricultural Service (USDA FAS) to globally monitor variations in root-zone soil moisture availability via the integration of satellite-based precipitation and soil moisture information. Prospects for improving the performance of the USDA FAS system via the simultaneous assimilation of both passive and active-based soil moisture retrievals derived from the upcoming NASA Soil Moisture Active/Passive mission will also be discussed.

SU-D-17A-07: Development and Evaluation of a Prototype Ultrasonography Respiratory Monitoring System for 4DCT Reconstruction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan, P; Cheng, S; Chao, C

Purpose: Respiratory motion artifacts are commonly seen in the abdominal and thoracic CT images. A Real-time Position Management (RPM) system is integrated with CT simulator using abdominal surface as a surrogate for tracking the patient respiratory motion. The respiratory-correlated four-dimensional computed tomography (4DCT) is then reconstructed by GE advantage software. However, there are still artifacts due to inaccurate respiratory motion detecting and sorting methods. We developed an Ultrasonography Respiration Monitoring (URM) system which can directly monitor diaphragm motion to detect respiratory cycles. We also developed a new 4DCT sorting and motion estimation method to reduce the respiratory motion artifacts. Themore » new 4DCT system was compared with RPM and the GE 4DCT system. Methods: Imaging from a GE CT scanner was simultaneously correlated with both the RPM and URM to detect respiratory motion. A radiation detector, Blackcat GM-10, recorded the X-ray on/off and synchronized with URM. The diaphragm images were acquired with Ultrasonix RP system. The respiratory wave was derived from diaphragm images and synchronized with CT scanner. A more precise peaks and valleys detection tool was developed and compared with RPM. The motion is estimated for the slices which are not in the predefined respiratory phases by using block matching and optical flow method. The CT slices were then sorted into different phases and reconstructed, compared with the images reconstructed from GE Advantage software using respiratory wave produced from RPM system. Results: The 4DCT images were reconstructed for eight patients. The discontinuity at the diaphragm level due to an inaccurate identification of phases by the RPM was significantly improved by URM system. Conclusion: Our URM 4DCT system was evaluated and compared with RPM and GE 4DCT system. The new system is user friendly and able to reduce motion artifacts. It also has the potential to monitor organ motion during therapy.« less

Optical monitoring of spinal cord hemodynamics, a feasibility study

NASA Astrophysics Data System (ADS)

Shadgan, Babak; Kwon, Brian K.; Streijger, Femke; Manouchehri, Neda; So, Kitty; Shortt, Katelyn; Cripton, Peter A.; Macnab, Andrew

2017-02-01

Background: After an acute traumatic spinal cord injury (SCI), the spinal cord is subjected to ischemia, hypoxia, and increased hydrostatic pressure which exacerbate further secondary damage and neuronal deficit. The purpose of this pilot study was to explore the use of near infrared spectroscopy (NIRS) for non-invasive and real-time monitoring of these changes within the injured spinal cord in an animal model. NIRS is a non-invasive optical technique that utilizes light in the near infrared spectrum to monitor changes in the concentration of tissue chromophores from which alterations in tissues oxygenation and perfusion can be inferred in real time. Methods: A custom-made miniaturized NIRS sensor was developed to monitor spinal cord hemodynamics and oxygenation noninvasively and in real time simultaneously with invasive, intraparenchymal monitoring in a pig model of SCI. The spinal cord around the T10 injury site was instrumented with intraparenchymal probes inserted directly into the spinal cord to measure oxygen pressure, blood flow, and hydrostatic pressure, and the same region of the spinal cord was monitored with the custom-designed extradural NIRS probe. We investigated how well the extradural NIRS probe detected intraparenchymal changes adjacent to the injury site after alterations in systemic blood pressure, global hypoxia, and traumatic injury generated by a weight-drop contusion. Results: The NIRS sensor successfully identified periods of systemic hypoxia, re-ventilation and changes in spinal cord perfusion and oxygenation during alterations of mean arterial pressure and following spinal cord injury. Conclusion: This pilot study indicates that extradural NIRS monitoring of the spinal cord is feasible as a non-invasive optical method to identify changes in spinal cord hemodynamics and oxygenation in real time. Further development of this technique would allow clinicians to monitor real-time physiologic changes within the injured spinal cord during the acute post-injury period.

Noncontact simultaneous dual wavelength photoplethysmography: A further step toward noncontact pulse oximetry

NASA Astrophysics Data System (ADS)

Humphreys, Kenneth; Ward, Tomas; Markham, Charles

2007-04-01

We present a camera-based device capable of capturing two photoplethysmographic (PPG) signals at two different wavelengths simultaneously, in a remote noncontact manner. The system comprises a complementary metal-oxide semiconductor camera and dual wavelength array of light emitting diodes (760 and 880nm). By alternately illuminating a region of tissue with each wavelength of light, and detecting the backscattered photons with the camera at a rate of 16frames/wavelengths, two multiplexed PPG wave forms are simultaneously captured. This process is the basis of pulse oximetry, and we describe how, with the inclusion of a calibration procedure, this system could be used as a noncontact pulse oximeter to measure arterial oxygen saturation (SpO2) remotely. Results from an experiment on ten subjects, exhibiting normal SpO2 readings, that demonstrate the instrument's ability to capture signals from a range of subjects under realistic lighting and environmental conditions are presented. We compare the signals captured by the noncontact system to a conventional PPG signal captured concurrently from a finger, and show by means of a J. Bland and D. Altman [Lancet 327, 307 (1986); Statistician 32, 307 (1983)] test, the noncontact device to be comparable to a contact device as a monitor of heart rate. We highlight some considerations that should be made when using camera-based "integrative" sampling methods and demonstrate through simulation, the suitability of the captured PPG signals for application of existing pulse oximetry calibration procedures.

Simultaneous NIRS and kinematics study of planning and execution of motor skill task: towards cerebral palsy rehabilitation

NASA Astrophysics Data System (ADS)

Chaudhary, Ujwal; Thompson, Bryant; Gonzalez, Jean; Jung, Young-Jin; Davis, Jennifer; Gonzalez, Patricia; Rice, Kyle; Bloyer, Martha; Elbaum, Leonard; Godavarty, Anuradha

2013-03-01

Cerebral palsy (CP) is a term that describes a group of motor impairment syndromes secondary to genetic and/or acquired disorders of the developing brain. In the current study, NIRS and motion capture were used simultaneously to correlate the brain's planning and execution activity during and with arm movement in healthy individual. The prefrontal region of the brain is non-invasively imaged using a custom built continuous-wave based near infrared spectroscopy (NIRS) system. The kinematics of the arm movement during the studies is recorded using an infrared based motion capture system, Qualisys. During the study, the subjects (over 18 years) performed 30 sec of arm movement followed by 30 sec rest for 5 times, both with their dominant and non-dominant arm. The optical signal acquired from NIRS system was processed to elucidate the activation and lateralization in the prefrontal region of participants. The preliminary results show difference, in terms of change in optical response, between task and rest in healthy adults. Currently simultaneous NIRS imaging and kinematics data are acquired in healthy individual and individual with CP in order to correlate brain activity to arm movement in real-time. The study has significant implication in elucidating the evolution in the functional activity of the brain as the physical movement of the arm evolves using NIRS. Hence the study has potential in augmenting the designing of training and hence rehabilitation regime for individuals with CP via kinematic monitoring and imaging brain activity.

Monitoring intracellular oxidative events using dynamic spectral unmixing microscopy

EPA Science Inventory

There is increasing interest in using live-cell imaging to monitor not just individual intracellular endpoints, but to investigate the interplay between multiple molecular events as they unfold in real time within the cell. A major impediment to simultaneous acquisition of multip...

Multiwavelength active-optics Shack-Hartmann sensor for monitoring seeing and turbulence outer scale

NASA Astrophysics Data System (ADS)

Martinez, P.

2014-12-01

Context. Real-time seeing and outer-scale estimation at the location of the focus of a telescope is fundamental for predicting the adaptive-optics system's dimensioning and performance, as well as for the operational aspects of instruments. Aims: This study attempts to take advantage of multiwavelength long-exposure images to instantaneously and simultaneously derive the turbulence outer scale and seeing from the full width at half maximum (FWHM) of seeing-limited images taken at the focus of a telescope. These atmospheric parameters are commonly measured in most observatories by different methods located away from the telescope platform, thus differing from the effective estimates at the focus of a telescope, mainly because of differences in pointing orientation, height above the ground, or local seeing bias (dome contribution). Methods: Long-exposure images can either be provided directly by any multiwavelength scientific imager or spectrograph or, alternatively from a modified active-optics Shack-Hartmann sensor (AOSH). From measuring the AOSH sensor spot point spread function FWHMs simultaneously at different wavelengths, one can estimate the instantaneous outer scale in addition to seeing. Results: Multiwavelength long-exposure images provide access to accurate estimates of r0 and L0 by adequate means as long as precise FWHMs can be obtained. Although AOSH sensors are specified to measure not spot sizes but slopes, real-time r0, and L0 measurements from spot FWHMs can be obtained at the critical location where they are needed with major advantages over scientific instrument images: insensitivity to the telescope field stabilization, and continuous availability. Conclusions: Assuming an alternative optical design that allows simultaneous multiwavelength images, the AOSH sensor benefits from all the advantages of real-time seeing and outer scale monitoring. With the substantial interest in the design of extremely large telescopes, such a system could be of considerable importance.

Predicting US Drought Monitor (USDM) states using precipitation, soil moisture, and evapotranspiration anomalies, Part I: Development of a non-discrete USDM index

USDA-ARS?s Scientific Manuscript database

The U.S. Drought Monitor (USDM) classifies drought into five discrete dryness/drought categories based on expert synthesis of numerous data sources. In this study, an empirical methodology is presented for creating a non-discrete U.S. Drought Monitor (USDM) index that simultaneously 1) represents th...

Layered acoustofluidic resonators for the simultaneous optical and acoustic characterisation of cavitation dynamics, microstreaming, and biological effects.

PubMed

Pereno, V; Aron, M; Vince, O; Mannaris, C; Seth, A; de Saint Victor, M; Lajoinie, G; Versluis, M; Coussios, C; Carugo, D; Stride, E

2018-05-01

The study of the effects of ultrasound-induced acoustic cavitation on biological structures is an active field in biomedical research. Of particular interest for therapeutic applications is the ability of oscillating microbubbles to promote both cellular and tissue membrane permeabilisation and to improve the distribution of therapeutic agents in tissue through extravasation and convective transport. The mechanisms that underpin the interaction between cavitating agents and tissues are, however, still poorly understood. One challenge is the practical difficulty involved in performing optical microscopy and acoustic emissions monitoring simultaneously in a biologically compatible environment. Here we present and characterise a microfluidic layered acoustic resonator ( μ LAR) developed for simultaneous ultrasound exposure, acoustic emissions monitoring, and microscopy of biological samples. The μ LAR facilitates in vitro ultrasound experiments in which measurements of microbubble dynamics, microstreaming velocity fields, acoustic emissions, and cell-microbubble interactions can be performed simultaneously. The device and analyses presented provide a means of performing mechanistic in vitro studies that may benefit the design of predictable and effective cavitation-based ultrasound treatments.

Process monitored spectrophotometric titration coupled with chemometrics for simultaneous determination of mixtures of weak acids.

PubMed

Liao, Lifu; Yang, Jing; Yuan, Jintao

2007-05-15

A new spectrophotometric titration method coupled with chemometrics for the simultaneous determination of mixtures of weak acids has been developed. In this method, the titrant is a mixture of sodium hydroxide and an acid-base indicator, and the indicator is used to monitor the titration process. In a process of titration, both the added volume of titrant and the solution acidity at each titration point can be obtained simultaneously from an absorption spectrum by least square algorithm, and then the concentration of each component in the mixture can be obtained from the titration curves by principal component regression. The method only needs the information of absorbance spectra to obtain the analytical results, and is free of volumetric measurements. The analyses are independent of titration end point and do not need the accurate values of dissociation constants of the indicator and the acids. The method has been applied to the simultaneous determination of the mixtures of benzoic acid and salicylic acid, and the mixtures of phenol, o-chlorophenol and p-chlorophenol with satisfactory results.

Development of an alpha/beta/gamma detector for radiation monitoring

NASA Astrophysics Data System (ADS)

Yamamoto, Seiichi; Hatazawa, Jun

2011-11-01

For radiation monitoring at the site of nuclear power plant accidents such as Fukushima Daiichi, radiation detectors not only for gamma photons but also for alpha and beta particles are needed because some nuclear fission products emit beta particles and gamma photons and some nuclear fuels contain plutonium that emits alpha particles. We developed a radiation detector that can simultaneously monitor alpha and beta particles and gamma photons for radiation monitoring. The detector consists of three-layered scintillators optically coupled to each other and coupled to a photomultiplier tube. The first layer, which is made of a thin plastic scintillator (decay time: 2.4 ns), detects alpha particles. The second layer, which is made of a thin Gd2SiO5 (GSO) scintillator with 1.5 mol.% Ce (decay time: 35 ns), detects beta particles. The third layer made of a thin GSO scintillator with 0.4 mol.% Ce (decay time: 70 ns) detects gamma photons. By using pulse shape discrimination, the count rates of these layers can be separated. With individual irradiation of alpha and beta particles and gamma photons, the count rate of the first layer represented the alpha particles, the second layer represented the beta particles, and the third layer represented the gamma photons. Even with simultaneous irradiation of the alpha and beta particles and the gamma photons, these three types of radiation can be individually monitored using correction for the gamma detection efficiency of the second and third layers. Our developed alpha, beta, and gamma detector is simple and will be useful for radiation monitoring, especially at nuclear power plant accident sites or other applications where the simultaneous measurements of alpha and beta particles and gamma photons are required.

Development of an alpha/beta/gamma detector for radiation monitoring.

PubMed

Yamamoto, Seiichi; Hatazawa, Jun

2011-11-01

For radiation monitoring at the site of nuclear power plant accidents such as Fukushima Daiichi, radiation detectors not only for gamma photons but also for alpha and beta particles are needed because some nuclear fission products emit beta particles and gamma photons and some nuclear fuels contain plutonium that emits alpha particles. We developed a radiation detector that can simultaneously monitor alpha and beta particles and gamma photons for radiation monitoring. The detector consists of three-layered scintillators optically coupled to each other and coupled to a photomultiplier tube. The first layer, which is made of a thin plastic scintillator (decay time: 2.4 ns), detects alpha particles. The second layer, which is made of a thin Gd(2)SiO(5) (GSO) scintillator with 1.5 mol.% Ce (decay time: 35 ns), detects beta particles. The third layer made of a thin GSO scintillator with 0.4 mol.% Ce (decay time: 70 ns) detects gamma photons. By using pulse shape discrimination, the count rates of these layers can be separated. With individual irradiation of alpha and beta particles and gamma photons, the count rate of the first layer represented the alpha particles, the second layer represented the beta particles, and the third layer represented the gamma photons. Even with simultaneous irradiation of the alpha and beta particles and the gamma photons, these three types of radiation can be individually monitored using correction for the gamma detection efficiency of the second and third layers. Our developed alpha, beta, and gamma detector is simple and will be useful for radiation monitoring, especially at nuclear power plant accident sites or other applications where the simultaneous measurements of alpha and beta particles and gamma photons are required. © 2011 American Institute of Physics

Distributed observing facility for remote access to multiple telescopes

NASA Astrophysics Data System (ADS)

Callegari, Massimo; Panciatici, Antonio; Pasian, Fabio; Pucillo, Mauro; Santin, Paolo; Aro, Simo; Linde, Peter; Duran, Maria A.; Rodriguez, Jose A.; Genova, Francoise; Ochsenbein, Francois; Ponz, J. D.; Talavera, Antonio

2000-06-01

The REMOT (Remote Experiment Monitoring and conTrol) project was financed by 1996 by the European Community in order to investigate the possibility of generalizing the remote access to scientific instruments. After the feasibility of this idea was demonstrated, the DYNACORE (DYNAmically, COnfigurable Remote Experiment monitoring and control) project was initiated as a REMOT follow-up. Its purpose is to develop software technology to support scientists in two different domains, astronomy and plasma physics. The resulting system allows (1) simultaneous multiple user access to different experimental facilities, (2) dynamic adaptability to different kinds of real instruments, (3) exploitation of the communication infrastructures features, (4) ease of use through intuitive graphical interfaces, and (5) additional inter-user communication using off-the-shelf projects such as video-conference tools, chat programs and shared blackboards.

Beam position monitor gate functionality implementation and applications

DOE PAGES

Cheng, Weixing; Ha, Kiman; Li, Yongjun; ...

2018-06-14

We introduce a novel technique to implement gate functionality for the beam position monitors (BPM) at the National Synchrotron Light Source II (NSLS-II). The functionality, now implemented in FPGA, allows us to acquire two separated bunch-trains’ synchronized turn-by-turn (TBT) data simultaneously with the NSLS-II in-house developed BPM system. The gated position resolution is improved about 3 times by narrowing the sampling width. Experimentally we demonstrated that the machine lattice could be transparently characterized with the gated TBT data of a short diagnostic bunch-train Cheng et al., 2017; Li et al., 2017. Other applications, for example, precisely characterizing storage ring impedance/wake-fieldmore » through recording the beam positions of two separated bunch trains has been experimentally demonstrated.« less

Beam position monitor gate functionality implementation and applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheng, Weixing; Ha, Kiman; Li, Yongjun

We introduce a novel technique to implement gate functionality for the beam position monitors (BPM) at the National Synchrotron Light Source II (NSLS-II). The functionality, now implemented in FPGA, allows us to acquire two separated bunch-trains’ synchronized turn-by-turn (TBT) data simultaneously with the NSLS-II in-house developed BPM system. The gated position resolution is improved about 3 times by narrowing the sampling width. Experimentally we demonstrated that the machine lattice could be transparently characterized with the gated TBT data of a short diagnostic bunch-train Cheng et al., 2017; Li et al., 2017. Other applications, for example, precisely characterizing storage ring impedance/wake-fieldmore » through recording the beam positions of two separated bunch trains has been experimentally demonstrated.« less

Optical quasi-distributed simultaneous vibration and temperature sensing in stator bars of a 370-MVA electric generator

NASA Astrophysics Data System (ADS)

Dreyer, Uilian José; Vagner da Silva, Erlon; Martelli, Cicero; Cardozo da Silva, Jean Carlos

2017-08-01

In this paper, we propose a new multiparametric optical fiber transducer applied to an electric generator of 370 MVA. The optical transducer has three multiplexed FBGs in the same optical fiber as the sensing element. The FBG sensors can simultaneously measure both the temperature and vibration independently of the other multiplexed FBGs. The installation in the power plant was performed using six transducers and it was obtained 23 hours of simultaneous vibration and temperature measurement. All the FBGs used to monitor generator vibration were able to monitor the frequency of mechanical and electromagnetic vibrations, which were measured at 2 Hz and 120 Hz, respectively. During the measurement, the machine was turned off due to a failure and all the FBGs sensed temperature changes, as well as frequency vibration changes. The largest temperature difference measured between the FBGs during the test is approximately 2°C.

Bird biodiversity assessments in temperate forest: the value of point count versus acoustic monitoring protocols.

PubMed

Klingbeil, Brian T; Willig, Michael R

2015-01-01

Effective monitoring programs for biodiversity are needed to assess trends in biodiversity and evaluate the consequences of management. This is particularly true for birds and faunas that occupy interior forest and other areas of low human population density, as these are frequently under-sampled compared to other habitats. For birds, Autonomous Recording Units (ARUs) have been proposed as a supplement or alternative to point counts made by human observers to enhance monitoring efforts. We employed two strategies (i.e., simultaneous-collection and same-season) to compare point count and ARU methods for quantifying species richness and composition of birds in temperate interior forests. The simultaneous-collection strategy compares surveys by ARUs and point counts, with methods matched in time, location, and survey duration such that the person and machine simultaneously collect data. The same-season strategy compares surveys from ARUs and point counts conducted at the same locations throughout the breeding season, but methods differ in the number, duration, and frequency of surveys. This second strategy more closely follows the ways in which monitoring programs are likely to be implemented. Site-specific estimates of richness (but not species composition) differed between methods; however, the nature of the relationship was dependent on the assessment strategy. Estimates of richness from point counts were greater than estimates from ARUs in the simultaneous-collection strategy. Woodpeckers in particular, were less frequently identified from ARUs than point counts with this strategy. Conversely, estimates of richness were lower from point counts than ARUs in the same-season strategy. Moreover, in the same-season strategy, ARUs detected the occurrence of passerines at a higher frequency than did point counts. Differences between ARU and point count methods were only detected in site-level comparisons. Importantly, both methods provide similar estimates of species richness and composition for the region. Consequently, if single visits to sites or short-term monitoring are the goal, point counts will likely perform better than ARUs, especially if species are rare or vocalize infrequently. However, if seasonal or annual monitoring of sites is the goal, ARUs offer a viable alternative to standard point-count methods, especially in the context of large-scale or long-term monitoring of temperate forest birds.

Personal carbon monoxide exposures of preschool children in Helsinki, Finland—comparison to ambient air concentrations

NASA Astrophysics Data System (ADS)

Alm, S.; Mukala, K.; Tiittanen, P.; Jantunen, M. J.

The associations of personal carbon monoxide (CO) exposures with ambient air CO concentrations measured at fixed monitoring sites, were studied among 194 children aged 3-6 yr in four downtown and four suburban day-care centers in Helsinki, Finland. Each child carried a personal CO exposure monitor between 1 and 4 times for a time period of between 20 and 24 h. CO concentrations at two fixed monitoring sites were measured simultaneously. The CO concentrations measured at the fixed monitoring sites were usually lower (mean maximum 8-h concentration: 0.9 and 2.6 mg m -3) than the personal CO exposure concentrations (mean maximum 8-h concentration: 3.3 mg m -3). The fixed site CO concentrations were poor predictors of the personal CO exposure concentrations. However, the correlations between the personal CO exposure and the fixed monitoring site CO concentrations increased (-0.03--0.12 to 0.13-0.16) with increasing averaging times from 1 to 8 h. Also, the fixed monitoring site CO concentrations explained the mean daily or weekly personal CO exposures of a group of simultaneously measured children better than individual exposure CO concentrations. This study suggests that the short-term CO personal exposure of children cannot be meaningfully assessed using fixed monitoring sites.

US EPA Base Study Standard Operating Procedure for Continuous Monitoring of Outdoor Air

EPA Pesticide Factsheets

The procedure described is intended for monitoring continuously and simultaneously outdoor air quality parameters that are most commonly associated with indoor air quality: the concentrations of carbon dioxide (CO2) and carbon monoxide (CO), temperature, nd relative humidity (RH).

"Internet of Things" Real-Time Free Flap Monitoring.

PubMed

Kim, Sang Hun; Shin, Ho Seong; Lee, Sang Hwan

2018-01-01

Free flaps are a common treatment option for head and neck reconstruction in plastic reconstructive surgery, and monitoring of the free flap is the most important factor for flap survival. In this study, the authors performed real-time free flap monitoring based on an implanted Doppler system and "internet of things" (IoT)/wireless Wi-Fi, which is a convenient, accurate, and efficient approach for surgeons to monitor a free flap. Implanted Doppler signals were checked continuously until the patient was discharged by the surgeon and residents using their own cellular phone or personal computer. If the surgeon decided that a revision procedure or exploration was required, the authors checked the consumed time (positive signal-to-operating room time) from the first notification when the flap's status was questioned to the determination for revision surgery according to a chart review. To compare the efficacy of real-time monitoring, the authors paired the same number of free flaps performed by the same surgeon and monitored the flaps using conventional methods such as a physical examination. The total survival rate was greater in the real-time monitoring group (94.7% versus 89.5%). The average time for the real-time monitoring group was shorter than that for the conventional group (65 minutes versus 86 minutes). Based on this study, real-time free flap monitoring using IoT technology is a method that surgeon and reconstruction team can monitor simultaneously at any time in any situation.

Simultaneous dielectric monitoring of microfluidic channels at microwaves utilizing a metamaterial transmission line structure.

PubMed

Schüßler, M; Puentes, M; Dubuc, D; Grenier, K; Jakoby, R

2012-01-01

The paper presents a technique that allows the simultaneous monitoring of the dielectric properties of liquids in microfluidic channels at microwave frequencies. It is capable of being integrated within the lab-on-a-chip concept and uses a composite right/left-handed transmission line resonator which is detuned by the dielectric loading of the liquids in the channels. By monitoring the change in the resonance spectrum of the resonator the loading profile can be derived with the multi-resonant perturbation method. From the value of the dielectric constant inference on the substances like cells or chemicals in the channels can be drawn. The paper presents concept, design, fabrication and characterization of prototype sensors. The sensors have been designed to operate between 20 and 30 GHz and were tested with water and water ethanol mixtures.

Tracer-monitored flow titrations.

PubMed

Sasaki, Milton K; Rocha, Diogo L; Rocha, Fábio R P; Zagatto, Elias A G

2016-01-01

The feasibility of implementing tracer-monitored titrations in a flow system is demonstrated. A dye tracer is used to estimate the instant sample and titrant volumetric fractions without the need for volume, mass or peak width measurements. The approach was applied to spectrophotometric flow titrations involving variations of sample and titrant flow-rates (i.e. triangle programmed technique) or concentration gradients established along the sample zone (i.e. flow injection system). Both strategies required simultaneous monitoring of two absorbing species, namely the titration indicator and the dye tracer. Mixing conditions were improved by placing a chamber with mechanical stirring in the analytical path aiming at to minimize diffusional effects. Unlike most of flow-based titrations, the innovation is considered as a true titration, as it does not require a calibration curve thus complying with IUPAC definition. As an application, acidity evaluation in vinegars involving titration with sodium hydroxide was selected. Phenolphthalein and brilliant blue FCF were used as indicator and dye tracer, respectively. Effects of sample volume, titrand/titrant concentrations and flow rates were investigated aiming at improved accuracy and precision. Results were reliable and in agreement with those obtained by a reference titration procedure. Copyright © 2015 Elsevier B.V. All rights reserved.

Continuous glucose monitors: current status and future developments.

PubMed

Lane, Jennifer E; Shivers, Joseph P; Zisser, Howard

2013-04-01

Advances in diabetes technologies allow patients to manage their diabetes with greater precision and flexibility. Many recent studies show that continuous glucose monitors (CGMs) can be used to tighten glycemic control safely and to ease certain burdens of diabetes self-management. The following summary reflects the most recent findings in CGM and provides an overall review of who would most benefit from CGM use. Benefits of CGM may vary based on age, type of diabetes, pregnancy, health, sleep, or heart rate. Accuracy and reliability are critical in current uses of CGM and especially for new and future systems that automate insulin partially (e.g., low glucose suspend) or entirely (e.g., 'fully closed-loop' artificial pancreas). Clinicians are simultaneously testing available products in new patient groups such as the critically ill and type 2 diabetes patients not using mealtime insulin. In a widening set of circumstances, use of CGM has been shown to promote safer and more effective glycemic control than self-monitoring of blood glucose. Imperfections remain in certain scenarios such as hypoglycemia and in certain populations such as young children. Ongoing research on sensors and calibration software should translate to better systems.

Ground-based Space Weather Monitoring with LOFAR

NASA Astrophysics Data System (ADS)

Wise, Michael; van Haarlem, Michiel; Lawrence, Gareth; Reid, Simon; Bos, Andre; Rawlings, Steve; Salvini, Stef; Mitchell, Cathryn; Soleimani, Manuch; Amado, Sergio; Teresa, Vital

As one of the first of a new generation of radio instruments, the International LOFAR Telescope (ILT) will provide a number of unique and novel capabilities for the astronomical community. These include remote configuration and operation, dynamic real-time processing and system response, and the ability to provide multiple simultaneous streams of data to a community whose scientific interests run the gamut from lighting in the atmospheres of distant planets to the origins of the universe itself. The LOFAR (LOw Frequency ARray) system is optimized for a frequency range from 30-240 MHz and consists of multiple antenna fields spread across Europe. In the Netherlands, a total 36 LOFAR stations are nearing completion with an initial 8 international stations currently being deployed in Germany, France, Sweden, and the UK. Digital beam-forming techniques make the LOFAR system agile and allow for rapid repointing of the telescope as well as the potential for multiple simultaneous observations. With its dense core array and long interferometric baselines, LOFAR has the potential to achieve unparalleled sensitivity and spatial resolution in the low frequency radio regime. LOFAR will also be one of the first radio observatories to feature automated processing pipelines to deliver fully calibrated science products to its user community. As we discuss in this presentation, the same capabilities that make LOFAR a powerful tool for radio astronomy also provide an excellent platform upon which to build a ground-based monitoring system for space weather events. For example, the ability to monitor Solar activity in near real-time is one of the key scientific capabilities being developed for LOFAR. With only a fraction of its total observing capacity, LOFAR will be able to provide continuous monitoring of the Solar spectrum over the entire 10-240 MHz band down to microsecond timescales. Autonomous routines will scan these incoming spectral data for evidence of Solar flares and be capable of generating various responses including alerting external observatories or reallocating internal observing capacity to create short cadence (1-10 sec) images of the Sun. More uniquely, the core development, already invested by LOFAR to produce astronomical images of the sky, makes an excellent framework on which to build a near real-time ionospheric monitor and thereby study the effects of space weather events on our atmosphere. One of the key technical challenges to producing high quality scientific images in the low frequency radio regime are the effects of the active ionosphere over the detector array on signal propagation through the earth's atmosphere. To correct for these effects, the current LOFAR system includes an adaptive calibration employing both single and multi-layer phase screen models for the ionosphere. The output of this calibration automatically produces continuous ionospheric measurements with a data cadence in seconds. Although limited to the sky over the array, the resulting TEC maps can have vertical and horizontal resolutions down to 2m and relative accuracies of 0.001 TECU. The intent is to publish both Solar and ionospheric data-streams to the space weather community providing an excellent complement to existing space-based monitoring assets. In this presentation, we will describe the current and planned capabilities of the LOFAR system as well as show some first examples of the potential data products taken during the ongoing commissioning phase. We will also discuss plans to build upon the current LOFAR infrastructure and provide a source of near real-time monitoring data to the space weather community.

3D Blade Vibration Measurements on an 80 m Diameter Wind Turbine by Using Non-contact Remote Measurement Systems

NASA Astrophysics Data System (ADS)

Ozbek, Muammer; Rixen, Daniel J.

Non-contact optical measurement systems photogrammetry and laser interferometry are introduced as cost efficient alternatives to the conventional wind turbine/farm monitoring systems that are currently in use. The proposed techniques are proven to provide an accurate measurement of the dynamic behavior of a 2.5 MW—80 m diameter—wind turbine. Several measurements are taken on the test turbine by using 4 CCD cameras and 1 laser vibrometer and the response of the turbine is monitored from a distance of 220 m. The results of the infield tests and the corresponding analyses show that photogrammetry (also can be called as videogrammetry or computer vision technique) enable the 3D deformations of the rotor to be measured at 33 different points simultaneously with an average accuracy of ±25 mm, while the turbine is rotating. Several important turbine modes can also be extracted from the recorded data. Similarly, laser interferometry (used for the parked turbine only) provides very valuable information on the dynamic properties of the turbine structure. Twelve different turbine modes can be identified from the obtained response data.

Noncontact blood perfusion mapping in clinical applications

NASA Astrophysics Data System (ADS)

Iakovlev, Dmitry; Dwyer, Vincent; Hu, Sijung; Silberschmidt, Vadim

2016-04-01

Non-contact imaging photoplethysmography (iPPG) to detect pulsatile blood microcirculation in tissue has been selected as a successor to low spatial resolution and slow scanning blood perfusion techniques currently employed by clinicians. The proposed iPPG system employs a novel illumination source constructed of multiple high power LEDs with narrow spectral emission, which are temporally modulated and synchronised with a high performance sCMOS sensor. To ensure spectrum stability and prevent thermal wavelength drift due to junction temperature variations, each LED features a custom-designed thermal management system to effectively dissipate generated heat and auto-adjust current flow. The use of a multi-wavelength approach has resulted in simultaneous microvascular perfusion monitoring at various tissue depths, which is an added benefit for specific clinical applications. A synchronous detection algorithm to extract weak photoplethysmographic pulse-waveforms demonstrated robustness and high efficiency when applied to even small regions of 5 mm2. The experimental results showed evidences that the proposed system could achieve noticeable accuracy in blood perfusion monitoring by creating complex amplitude and phase maps for the tissue under examination.

Integrating remote sensing, geographic information systems and global positioning system techniques with hydrological modeling

NASA Astrophysics Data System (ADS)

Thakur, Jay Krishna; Singh, Sudhir Kumar; Ekanthalu, Vicky Shettigondahalli

2017-07-01

Integration of remote sensing (RS), geographic information systems (GIS) and global positioning system (GPS) are emerging research areas in the field of groundwater hydrology, resource management, environmental monitoring and during emergency response. Recent advancements in the fields of RS, GIS, GPS and higher level of computation will help in providing and handling a range of data simultaneously in a time- and cost-efficient manner. This review paper deals with hydrological modeling, uses of remote sensing and GIS in hydrological modeling, models of integrations and their need and in last the conclusion. After dealing with these issues conceptually and technically, we can develop better methods and novel approaches to handle large data sets and in a better way to communicate information related with rapidly decreasing societal resources, i.e. groundwater.

On the use of volumetric strain meters to infer additional characteristics of short-period seismic radiation

USGS Publications Warehouse

Borcherdt, R.D.; Johnston, M.J.S.; Glassmoyer, G.

1989-01-01

Volumetric strain meters (Sacks-Evertson design) are installed at 15 sites along the San Andreas fault system, to monitor long-term strain changes for earthquake prediction. Deployment of portable broadband, high-resolution digital recorders (GEOS) at several of the sites extends the detection band for volumetric strain to periods shorter than 5 ?? 10-2 sec and permits the simultaneous observation of seismic radiation fields using conventional short-period pendulum seismometers. Recordings of local and regional earthquakes indicate that dilatometers respond to P energy but not direct shear energy and that straingrams can be used to resolve superimposed reflect P and S waves for inference of wave characteristics not permitted by either sensor alone. Simultaneous measurements of incident P- and S-wave amplitudes are used to introduce a technique for single-station estimates of wave field inhomogeneity, free-surface reflection coefficients and local material P velocity. -from Authors

Non-contact and through-clothing measurement of the heart rate using ultrasound vibrocardiography.

PubMed

Jeger-Madiot, Nathan; Gateau, Jérôme; Fink, Mathias; Ing, Ros-Kiri

2017-12-01

We present a novel non-contact system for monitoring the heart rate on human subjects with clothes. Our approach is based on vibrocardiography, and measures locally skin displacements. Vibrocardiography with a laser Doppler vibrometer already allows monitoring of this vital sign, but can only be used on bare skin and requires an expensive piece of equipment. We propose here to use an airborne pulse-Doppler ultrasound system operating in the 20-60 kHz range, and comprised of an emitter focusing the ultrasound pulses on skin and a microphone recording the reflected waves. Our implementation was validated in vitro and on two healthy human subjects, using simultaneously laser vibrocardiography and electrocardiography as references. Accurate measurements of the heart rate on clothed skin suggest that our non-contact ultrasonic method could be implemented both inside and outside the clinical environment, and therefore benefit both medical and safety applications. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

Monitoring of Water Spectral Pattern Reveals Differences in Probiotics Growth When Used for Rapid Bacteria Selection.

PubMed

Slavchev, Aleksandar; Kovacs, Zoltan; Koshiba, Haruki; Nagai, Airi; Bázár, György; Krastanov, Albert; Kubota, Yousuke; Tsenkova, Roumiana

2015-01-01

Development of efficient screening method coupled with cell functionality evaluation is highly needed in contemporary microbiology. The presented novel concept and fast non-destructive method brings in to play the water spectral pattern of the solution as a molecular fingerprint of the cell culture system. To elucidate the concept, NIR spectroscopy with Aquaphotomics were applied to monitor the growth of sixteen Lactobacillus bulgaricus one Lactobacillus pentosus and one Lactobacillus gasseri bacteria strains. Their growth rate, maximal optical density, low pH and bile tolerances were measured and further used as a reference data for analysis of the simultaneously acquired spectral data. The acquired spectral data in the region of 1100-1850nm was subjected to various multivariate data analyses - PCA, OPLS-DA, PLSR. The results showed high accuracy of bacteria strains classification according to their probiotic strength. Most informative spectral fingerprints covered the first overtone of water, emphasizing the relation of water molecular system to cell functionality.

An object-oriented approach to data display and storage: 3 years experience, 25,000 cases.

PubMed

Sainsbury, D A

1993-11-01

Object-oriented programming techniques were used to develop computer based data display and storage systems. These have been operating in the 8 anaesthetising areas of the Adelaide Children's Hospital for 3 years. The analogue and serial outputs from an array of patient monitors are connected to IBM compatible PC-XT computers. The information is displayed on a colour screen as wave-form and trend graphs and digital format in 'real time'. The trend data is printed simultaneously on a dot matrix printer. This data is also stored for 24 hours on 'hard' disk. The major benefit has been the provision of a single visual focus for all monitored variables. The automatic logging of data has been invaluable in the analysis of critical incidents. The systems were made possible by recent, rapid improvements in computer hardware and software. This paper traces the development of the program and demonstrates the advantages of object-oriented programming techniques.

CCD Camera Lens Interface for Real-Time Theodolite Alignment

NASA Technical Reports Server (NTRS)

Wake, Shane; Scott, V. Stanley, III

2012-01-01

Theodolites are a common instrument in the testing, alignment, and building of various systems ranging from a single optical component to an entire instrument. They provide a precise way to measure horizontal and vertical angles. They can be used to align multiple objects in a desired way at specific angles. They can also be used to reference a specific location or orientation of an object that has moved. Some systems may require a small margin of error in position of components. A theodolite can assist with accurately measuring and/or minimizing that error. The technology is an adapter for a CCD camera with lens to attach to a Leica Wild T3000 Theodolite eyepiece that enables viewing on a connected monitor, and thus can be utilized with multiple theodolites simultaneously. This technology removes a substantial part of human error by relying on the CCD camera and monitors. It also allows image recording of the alignment, and therefore provides a quantitative means to measure such error.

Biparametric potentiometric analytical microsystem for nitrate and potassium monitoring in water recycling processes for manned space missions.

PubMed

Calvo-López, Antonio; Arasa-Puig, Eva; Puyol, Mar; Casalta, Joan Manel; Alonso-Chamarro, Julián

2013-12-04

The construction and evaluation of a Low Temperature Co-fired Ceramics (LTCC)-based continuous flow potentiometric microanalyzer prototype to simultaneously monitor the presence of two ions (potassium and nitrate) in samples from the water recycling process for future manned space missions is presented. The microsystem integrates microfluidics and the detection system in a single substrate and it is smaller than a credit card. The detection system is based on two ion-selective electrodes (ISEs), which are built using all-solid state nitrate and potassium polymeric membranes, and a screen-printed Ag/AgCl reference electrode. The obtained analytical features after the optimization of the microfluidic design and hydrodynamics are a linear range from 10 to 1000 mg L(-1) and from 1.9 to 155 mg L(-1) and a detection limit of 9.56 mg L(-1) and 0.81 mg L(-1) for nitrate and potassium ions respectively. Copyright © 2013 Elsevier B.V. All rights reserved.

Software for Remote Monitoring of Space-Station Payloads

NASA Technical Reports Server (NTRS)

Schneider, Michelle; Lippincott, Jeff; Chubb, Steve; Whitaker, Jimmy; Gillis, Robert; Sellers, Donna; Sims, Chris; Rice, James

2003-01-01

Telescience Resource Kit (TReK) is a suite of application programs that enable geographically dispersed users to monitor scientific payloads aboard the International Space Station (ISS). TReK provides local ground support services that can simultaneously receive, process, record, playback, and display data from multiple sources. TReK also provides interfaces to use the remote services provided by the Payload Operations Integration Center which manages all ISS payloads. An application programming interface (API) allows for payload users to gain access to all data processed by TReK and allows payload-specific tools and programs to be built or integrated with TReK. Used in conjunction with other ISS-provided tools, TReK provides the ability to integrate payloads with the operational ground system early in the lifecycle. This reduces the potential for operational problems and provides "cradle-to-grave" end-to-end operations. TReK contains user guides and self-paced tutorials along with training applications to allow the user to become familiar with the system.

High-speed and high-fidelity system and method for collecting network traffic

DOEpatents

Weigle, Eric H [Los Alamos, NM

2010-08-24

A system is provided for the high-speed and high-fidelity collection of network traffic. The system can collect traffic at gigabit-per-second (Gbps) speeds, scale to terabit-per-second (Tbps) speeds, and support additional functions such as real-time network intrusion detection. The present system uses a dedicated operating system for traffic collection to maximize efficiency, scalability, and performance. A scalable infrastructure and apparatus for the present system is provided by splitting the work performed on one host onto multiple hosts. The present system simultaneously addresses the issues of scalability, performance, cost, and adaptability with respect to network monitoring, collection, and other network tasks. In addition to high-speed and high-fidelity network collection, the present system provides a flexible infrastructure to perform virtually any function at high speeds such as real-time network intrusion detection and wide-area network emulation for research purposes.

Feasibility of measuring temperature and density fluctuations in air using laser-induced O2 fluorescence

NASA Technical Reports Server (NTRS)

Massey, G. A.; Lemon, C. J.

1984-01-01

A tunable line-narrowed ArF laser can selectively excite several rotation al lines of the Schumann-Runge band system of O2 in air. The resulting ultraviolet fluorescence can be monitored at 90 deg to the laser beam axis, permitting space and time resolved observation of density and temperature fluctuations in turbulence. Experiments and calculations show that + or - 1 K, + or - 1 percent density, 1 cu mm spatial, and 1 microsecond temporal resolution can be achieved simultaneously under some conditions.

Material-specific detection and classification of single nanoparticles

PubMed Central

Person, Steven; Deutsch, Bradley; Mitra, Anirban; Novotny, Lukas

2010-01-01

Detection and classification of nanoparticles is important for environmental monitoring, contamination mitigation, biological label tracking, and bio-defense. Detection techniques involve a trade-off between sensitivity, discrimination, and speed. This paper presents a material-specific dual-color common-path interferometric detection system. Two wavelengths are simultaneously used to discriminate between 60 nm silver and 80 nm diameter gold particles in solution with a detection time of τ ≈ 1 ms. The detection technique is applicable to situations where both particle size and material are of interest. PMID:21142033

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, Ching-Yen; Shepelev, Aleksey; Qiu, Charlie

With an increased number of Electric Vehicles (EVs) on the roads, charging infrastructure is gaining an ever-more important role in simultaneously meeting the needs of the local distribution grid and of EV users. This paper proposes a mesh network RFID system for user identification and charging authorization as part of a smart charging infrastructure providing charge monitoring and control. The Zigbee-based mesh network RFID provides a cost-efficient solution to identify and authorize vehicles for charging and would allow EV charging to be conducted effectively while observing grid constraints and meeting the needs of EV drivers

Global positioning system network analysis with phase ambiguity resolution applied to crustal deformation studies in California

NASA Technical Reports Server (NTRS)

Dong, Da-Nan; Bock, Yehuda

1989-01-01

An efficient algorithm is developed for multisession adjustment of GPS data with simultaneous orbit determination and ambiguity resolution. Application of the algorithm to the analysis of data from a five-year campaign in progress in southern and central California to monitor tectonic motions using observations by GPS satellites, demonstrates improvements in estimates of station position and satellite orbits when the phase ambiguities are resolved. Most of the phase ambiguities in the GPS network were resolved, particularly for all the baselines of geophysical interest in California.

Self-assembly of marine exudate particles and their impact on the CCN properties of nascent marine aerosol

NASA Astrophysics Data System (ADS)

Schill, S.; Zimmermann, K.; Ryder, O. S.; Campbell, N.; Collins, D. B.; Gianneschi, N.; Bertram, T. H.

2013-12-01

Spontaneous self-assembly of marine exudate particles has previously been observed in filtered seawater samples. The chemicophysical properties of these particles may alter the chemical composition and CCN properties of nascent marine aerosol, yet to date simultaneous measurement of seawater exudate particle formation rates and number distributions, with aerosol particle formation rates and CCN activity are lacking. Here, we use a novel Marine Aerosol Reference Tank (MART) system to experimentally mimic a phytoplankton bloom via sequential addition of biological surrogates, including sterol, galactose, lipopolysaccharide, BSA protein, and dipalmitoylphosphatidylcholine. Nascent sea-spray aerosol are generated in the MART system via a continuous plunging waterfall. Exudate particle assembly in the water is monitored via dynamic light scattering (DLS) and transmission electron microscopy (TEM) to obtain both the assembly kinetics of the particles as well as particle number distributions Simultaneous characterization of both particle production rates and super-saturated particle hygroscopicity are also discussed. This study permits analysis of the controlling role of the molecular composition of dissolved organic carbon in setting the production rates of colloidal material in the surface oceans.

Combining optical trapping in a microfluidic channel with simultaneous micro-Raman spectroscopy and motion detection

NASA Astrophysics Data System (ADS)

Lawton, Penelope F.; Saunter, Christopher D.; Girkin, John M.

2014-03-01

Since their invention by Ashkin optical tweezers have demonstrated their ability and versatility as a non-invasive tool for micromanipulation. One of the most useful additions to the basic optical tweezers system is micro-Raman spectroscopy, which permits highly sensitive analysis of single cells or particles. We report on the development of a dual laser system combining two spatial light modulators to holographically manipulate multiple traps (at 1064nm) whilst undertaking Raman spectroscopy using a 532nm laser. We can thus simultaneously trap multiple particles and record their Raman spectra, without perturbing the trapping system. The dual beam system is built around micro-fluidic channels where crystallisation of calcium carbonate occurs on polymethylmethacrylate (PMMA) beads. The setup is designed to simulate at a microscopic level the reactions that occur on items in a dishwasher, where permanent filming of calcium carbonate on drinking glasses is a problem. Our system allows us to monitor crystal growth on trapped particles in which the Raman spectrum and changes in movement of the bead are recorded. Due to the expected low level of crystallisation on the bead surfaces this allows us to obtain results quickly and with high sensitivity. The long term goal is to study the development of filming on samples in-situ with the microfl.uidic system acting as a model dishwasher.

Diagnostics Adapted for Heat-Treating Furnace Environment

NASA Technical Reports Server (NTRS)

2005-01-01

Diagnostics developed for the in situ monitoring of rocket combustion environments were adapted for use in heat-treating furnaces. Simultaneous, in situ monitoring of the carbon monoxide, carbon dioxide, methane, water, and hydrogen concentrations in the endothermic gas of a heat-treating furnace were demonstrated under a Space Act Agreement between the NASA Lewis Research Center, the Heat Treating Network, and Akron Steel Treating Company. This endothermic gas, or "endogas," is produced in a catalytic process, where natural gas is "cracked" in the presence of air. Variations in the composition of the natural gas supplied lead to variations in the composition of the endothermic gas. These variations could lead to an unacceptable quality of steel products that are hardened through the carborization process that uses this gas. Conventional methods of monitoring the endogas include measuring the dew point of the gas and the oxygen concentration. From these data, the carbon monoxide content of the gas can be calculated. This carbon monoxide concentration creates the carbon potential needed for carburization. Several weak links are present in this approach. The oxygen monitor deteriorates over time, and the measurement might be inaccurate by 50 percent. Also, the chemistry equations, which are based on several assumptions, such as secondary species concentrations, provide only an approximate estimate of the carbon monoxide concentration. To address these weaknesses, we investigated a new method based on ordinary Raman spectroscopy, in which the carbon monoxide concentration is measured directly and in situ. This method measures the laser light scattered from the molecules. Each species interacts with the light and scatters the light at a different frequency. Spectral monitoring of the scattered light intensity at each molecular frequency of interest provides the species concentrations. One advantage over the conventional method is that several species can be monitored simultaneously. A second advantage is that the measurement is direct; there is no need to make assumptions, to filter the gas, or to calibrate the instrument. An instrument was designed consisting of a laser and a detection system within an enclosure, connected to an optical probe by fibers. For determining carbon monoxide concentration, the probe is mounted on the endothermic gas line, close to the generator. Optical fibers with a length of 150 ft have been used to transmit laser light from the instrument to the probe. There, the light is focused into the gas, and the scattered light is collected and transmitted back to the instrument where it is analyzed with a photomultiplier and lock-in amplifier. Laboratory tests have shown that with the current system the concentration of carbon monoxide, water, nitrogen, oxygen, and hydrogen in the air can be monitored with an accuracy of 1 percent. The concentration of carbon dioxide in the air can be monitored with an accuracy of 0.5 percent, and the concentration of methane with an accuracy of 0.2 percent. This instrument was taken to the Akron Steel Treating Plant, where field tests are in progress to verify the system capabilities. Planned developments are improving the accuracy, monitoring multiple locations, and reducing instrument size and cost.

Verification and compensation of respiratory motion using an ultrasound imaging system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chuang, Ho-Chiao, E-mail: hchuang@mail.ntut.edu.tw; Hsu, Hsiao-Yu; Chiu, Wei-Hung

Purpose: The purpose of this study was to determine if it is feasible to use ultrasound imaging as an aid for moving the treatment couch during diagnosis and treatment procedures associated with radiation therapy, in order to offset organ displacement caused by respiratory motion. A noninvasive ultrasound system was used to replace the C-arm device during diagnosis and treatment with the aims of reducing the x-ray radiation dose on the human body while simultaneously being able to monitor organ displacements. Methods: This study used a proposed respiratory compensating system combined with an ultrasound imaging system to monitor the compensation effectmore » of respiratory motion. The accuracy of the compensation effect was verified by fluoroscopy, which means that fluoroscopy could be replaced so as to reduce unnecessary radiation dose on patients. A respiratory simulation system was used to simulate the respiratory motion of the human abdomen and a strain gauge (respiratory signal acquisition device) was used to capture the simulated respiratory signals. The target displacements could be detected by an ultrasound probe and used as a reference for adjusting the gain value of the respiratory signal used by the respiratory compensating system. This ensured that the amplitude of the respiratory compensation signal was a faithful representation of the target displacement. Results: The results show that performing respiratory compensation with the assistance of the ultrasound images reduced the compensation error of the respiratory compensating system to 0.81–2.92 mm, both for sine-wave input signals with amplitudes of 5, 10, and 15 mm, and human respiratory signals; this represented compensation of the respiratory motion by up to 92.48%. In addition, the respiratory signals of 10 patients were captured in clinical trials, while their diaphragm displacements were observed simultaneously using ultrasound. Using the respiratory compensating system to offset, the diaphragm displacement resulted in compensation rates of 60%–84.4%. Conclusions: This study has shown that a respiratory compensating system combined with noninvasive ultrasound can provide real-time compensation of the respiratory motion of patients.« less

Multi-agent planning and scheduling, execution monitoring and incremental rescheduling: Application to motorway traffic

NASA Technical Reports Server (NTRS)

Mourou, Pascal; Fade, Bernard

1992-01-01

This article describes a planning method applicable to agents with great perception and decision-making capabilities and the ability to communicate with other agents. Each agent has a task to fulfill allowing for the actions of other agents in its vicinity. Certain simultaneous actions may cause conflicts because they require the same resource. The agent plans each of its actions and simultaneously transmits these to its neighbors. In a similar way, it receives plans from the other agents and must take account of these plans. The planning method allows us to build a distributed scheduling system. Here, these agents are robot vehicles on a highway communicating by radio. In this environment, conflicts between agents concern the allocation of space in time and are connected with the inertia of the vehicles. Each vehicle made a temporal, spatial, and situated reasoning in order to drive without collision. The flexibility and reactivity of the method presented here allows the agent to generate its plan based on assumptions concerning the other agents and then check these assumptions progressively as plans are received from the other agents. A multi-agent execution monitoring of these plans can be done, using data generated during planning and the multi-agent decision-making algorithm described here. A selective backtrack allows us to perform incremental rescheduling.

Relative skills of soil moisture and vegetation optical depth retrievals for agricultural drought monitoring

USDA-ARS?s Scientific Manuscript database

Soil moisture condition is an important indicator for agricultural drought monitoring. Through the Land Parameter Retrieval Model (LPRM), vegetation optical depth (VOD) as well as surface soil moisture (SM) can be retrieved simultaneously from brightness temperature observations from the Advanced Mi...

Markerless Knee Joint Position Measurement Using Depth Data during Stair Walking

PubMed Central

Mita, Akira; Yorozu, Ayanori; Takahashi, Masaki

2017-01-01

Climbing and descending stairs are demanding daily activities, and the monitoring of them may reveal the presence of musculoskeletal diseases at an early stage. A markerless system is needed to monitor such stair walking activity without mentally or physically disturbing the subject. Microsoft Kinect v2 has been used for gait monitoring, as it provides a markerless skeleton tracking function. However, few studies have used this device for stair walking monitoring, and the accuracy of its skeleton tracking function during stair walking has not been evaluated. Moreover, skeleton tracking is not likely to be suitable for estimating body joints during stair walking, as the form of the body is different from what it is when it walks on level surfaces. In this study, a new method of estimating the 3D position of the knee joint was devised that uses the depth data of Kinect v2. The accuracy of this method was compared with that of the skeleton tracking function of Kinect v2 by simultaneously measuring subjects with a 3D motion capture system. The depth data method was found to be more accurate than skeleton tracking. The mean error of the 3D Euclidian distance of the depth data method was 43.2 ± 27.5 mm, while that of the skeleton tracking was 50.4 ± 23.9 mm. This method indicates the possibility of stair walking monitoring for the early discovery of musculoskeletal diseases. PMID:29165396

Metrology for AGP - Astrometric Gravitation Probe

NASA Astrophysics Data System (ADS)

Gai, Mario; et al.

2015-08-01

The Astrometric Gravitation Probe (AGP) is a concept of space mission aimed at tests of Fundamental Physics in the Solar system, using Fizeau interferometry and coronagraphy techniques to implement differential astrometry among superposed stellar fields. The main goal is verification of the General Relativity (GR) and competing gravitation theories in the weak field of the Solar System by high precision measurement of the light deflection in the vicinity of the Sun at < 10-7 and of the main and minor planet dynamics at the microarcsec/year level. The AGP payload concept is based on a single main telescope (1.15 m diameter) implementing a multi-aperture Fizeau interferometer, for simultaneous observation of four regions close to the Solar limb and in opposition; coronagraphic techniques are applied on the elementary sub-apertures. The star displacement due to light deflection is derived by differential astrometry on images taken in different deflection conditions (e.g. ON and OFF). The instrument design is focused on systematic error control through multiple field simultaneous observation and calibration. The metrology system requirements related to the science goals are discussed, and the technical aspects of possible implementations are investigated. The potential benefit of auto-collimation and cophasing techniques derives from monitoring comparably large sections of the optical system common to the stellar beams. The performance at microarcsec level is verified by simulation.

Effect of time spacing on the perceived color

NASA Astrophysics Data System (ADS)

Roch, Sylvain; Hardeberg, Jon Y.; Nussbaum, Peter

2007-01-01

One of latest developments for pre-press applications is the concept of soft proofing, which aims to provide an accurate preview on a monitor of how the final document will appear once it is printed. At the core of this concept is the problem of identifying, for any printed color, the most similar color the monitor can display. This problem is made difficult by such factors as varying viewing conditions, color gamut limitations, or the less studied time spacing. Color matching experiments are usually done by examining samples viewed simultaneously. However, in soft proofing applications, the proof and the print are not always viewed together. This paper attempts to shed more light on the difference between simultaneous and time-spaced color matching, in order to contribute to improving the accuracy of soft proofs. A color matching experiment setup has been established in which observers were asked to match a color patch displayed on a LCD monitor, by adjusting its RGB values, to another color patch printed out on paper. In the first part of the experiment the two colors were viewed simultaneously. In the second part, the observers were asked to produce the match according to a previously memorized color. According to the obtained results, the color appearance attributes lightness and chroma were the most difficult components for the observers to remember, generating huge differences with the simultaneous match, whereas hue was the component which varied the least. This indicates that for soft proofing, getting the hues right is of primordial importance.

Adaptive noise cancelling and time-frequency techniques for rail surface defect detection

NASA Astrophysics Data System (ADS)

Liang, B.; Iwnicki, S.; Ball, A.; Young, A. E.

2015-03-01

Adaptive noise cancelling (ANC) is a technique which is very effective to remove additive noises from the contaminated signals. It has been widely used in the fields of telecommunication, radar and sonar signal processing. However it was seldom used for the surveillance and diagnosis of mechanical systems before late of 1990s. As a promising technique it has gradually been exploited for the purpose of condition monitoring and fault diagnosis. Time-frequency analysis is another useful tool for condition monitoring and fault diagnosis purpose as time-frequency analysis can keep both time and frequency information simultaneously. This paper presents an ANC and time-frequency application for railway wheel flat and rail surface defect detection. The experimental results from a scaled roller test rig show that this approach can significantly reduce unwanted interferences and extract the weak signals from strong background noises. The combination of ANC and time-frequency analysis may provide us one of useful tools for condition monitoring and fault diagnosis of railway vehicles.

The Use of Gamma-Ray Imaging to Improve Portal Monitor Performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ziock, Klaus-Peter; Collins, Jeff; Fabris, Lorenzo

2008-01-01

We have constructed a prototype, rapid-deployment portal monitor that uses visible-light and gamma-ray imaging to allow simultaneous monitoring of multiple lanes of traffic from the side of a roadway. Our Roadside Tracker uses automated target acquisition and tracking (TAT) software to identify and track vehicles in visible light images. The field of view of the visible camera overlaps with and is calibrated to that of a one-dimensional gamma-ray imager. The TAT code passes information on when vehicles enter and exit the system field of view and when they cross gamma-ray pixel boundaries. Based on this in-formation, the gamma-ray imager "harvests"more » the gamma-ray data specific to each vehicle, integrating its radiation signature for the entire time that it is in the field of view. In this fashion we are able to generate vehicle-specific radiation signatures and avoid source confusion problems that plague nonimaging approaches to the same problem.« less

Monitoring of the tidal dynamics of the Dutch Waddensea by SIR-B

NASA Technical Reports Server (NTRS)

Koopmans, B. N.; Vanderzee, D.; Verstappen, A. T.; Woldai, T.; Hoschititzky, H.

1984-01-01

The potential of LANDSAT data, covering the entire tidal flats at a certain, known, tidal situation, was assessed. It was discovered that the data cannot be used for systematic survey because of the long interval between subsequent passes, weather conditions often interfere with recording, and of the lack of correlation between passes and the tidal situation. The objective is to overcome the problems by using: (1) the synoptic view obtained by SIR-B, which has the potential of surveying large areas of the flats simultaneously; (2) the all-weather capability of the microwave system; (3) the recording during consecutive days, which results in a straightforeward correlation with the tidal cycle and the picturing of different tidal stages; and (4) the multiangle incidence of SIR-B to analyze the bottom configuration of submerged parts of the flats. The use of a weather independent monitoring device, such as radar, an improvement in the monitoring technique of tidal coastal areas.

Simultaneous determination of 13 fluoroquinolone and 22 sulfonamide residues in milk by a dual-colorimetric enzyme-linked immunosorbent assay

USDA-ARS?s Scientific Manuscript database

Enzyme-linked immunosorbent assays (ELISAs) usually focus on the detection of a single analyte or a single group of analytes, e.g., fluoroquinolones or sulfonamides. However, it is often necessary to simultaneously monitor the two classes of antimicrobial residues in different food matrices. In th...

CT and Ultrasound Guided Stereotactic High Intensity Focused Ultrasound (HIFU)

NASA Astrophysics Data System (ADS)

Wood, Bradford J.; Yanof, J.; Frenkel, V.; Viswanathan, A.; Dromi, S.; Oh, K.; Kruecker, J.; Bauer, C.; Seip, R.; Kam, A.; Li, K. C. P.

2006-05-01

To demonstrate the feasibility of CT and B-mode Ultrasound (US) targeted HIFU, a prototype coaxial focused ultrasound transducer was registered and integrated to a CT scanner. CT and diagnostic ultrasound were used for HIFU targeting and monitoring, with the goals of both thermal ablation and non-thermal enhanced drug delivery. A 1 megahertz coaxial ultrasound transducer was custom fabricated and attached to a passive position-sensing arm and an active six degree-of-freedom robotic arm via a CT stereotactic frame. The outer therapeutic transducer with a 10 cm fixed focal zone was coaxially mounted to an inner diagnostic US transducer (2-4 megahertz, Philips Medical Systems). This coaxial US transducer was connected to a modified commercial focused ultrasound generator (Focus Surgery, Indianapolis, IN) with a maximum total acoustic power of 100 watts. This pre-clinical paradigm was tested for ability to heat tissue in phantoms with monitoring and navigation from CT and live US. The feasibility of navigation via image fusion of CT with other modalities such as PET and MRI was demonstrated. Heated water phantoms were tested for correlation between CT numbers and temperature (for ablation monitoring). The prototype transducer and integrated CT/US imaging system enabled simultaneous multimodality imaging and therapy. Pre-clinical phantom models validated the treatment paradigm and demonstrated integrated multimodality guidance and treatment monitoring. Temperature changes during phantom cooling corresponded to CT number changes. Contrast enhanced or non-enhanced CT numbers may potentially be used to monitor thermal ablation with HIFU. Integrated CT, diagnostic US, and therapeutic focused ultrasound bridges a gap between diagnosis and therapy. Preliminary results show that the multimodality system may represent a relatively inexpensive, accessible, and simple method of both targeting and monitoring HIFU effects. Small animal pre-clinical models may be translated to large animals and humans for HIFU-induced ablation and drug delivery. Integrated CT-guided focused ultrasound holds promise for tissue ablation, enhancing local drug delivery, and CT thermometry for monitoring ablation in near real-time.

Hyperacute Simultaneous Cardiocerebral Infarction: Rescuing the Brain or the Heart First?

PubMed

Kijpaisalratana, Naruchorn; Chutinet, Aurauma; Suwanwela, Nijasri C

2017-01-01

Concurrent acute ischemic stroke and acute myocardial infarction is an uncommon medical emergency condition. The challenge for the physicians regarding the management of this situation is paramount since early management of one condition will inevitably delay the other. We present two illustrative cases of "hyperacute simultaneous cardiocerebral infarction" who presented with simultaneous cardiocerebral infarction and arrived at the hospital within the thrombolytic therapeutic window for acute ischemic stroke of 4.5 h. We propose an algorithm for managing the patient with hyperacute simultaneous cardiocerebral infarction based on hemodynamic status and suggest close cardiac monitoring based on the site of cerebral infarction.

Small diameter, deep bore optical inspection system

DOEpatents

Lord, D.E.; Petrini, R.R.; Carter, G.W.

An improved rod optic system for inspecting small diameter, deep bores is described. The system consists of a rod optic system utilizing a curved mirror at the end of the rod lens such that the optical path through the system is bent 90/sup 0/ to minimize optical distortion in examing the sides of a curved bore. The system is particularly useful in the examination of small bores for corrosion, and is capable if examing 1/16 inch diameter and up to 4-inch deep drill holes, for example. The positioning of the curved mirror allows simultaneous viewing from shallow and righ angle points of observation of the same artifact (such as corrosion) in the bore hole. The improved rod optic system may be used for direct eye sighting, or in combination with a still camera or a low-light television monitor; particularly low-light color television.

US EPA Base Study Standard Operating Procedure for Continuous Monitoring of Indoor Air

EPA Pesticide Factsheets

The procedure described is intended for monitoring continuously and simultaneously, at selected work sites, parameters that are most commonly associated with the quality of indoor environments: the concentrations of carbon dioxide (CO2), carbon monoxide (CO), temperature, relative humidity (RH), illumination, and noise.

Laboratory evaluation of dual-frequency multisensor capacitance probes to monitor soil water and salinity

USDA-ARS?s Scientific Manuscript database

Real-time information on salinity levels and transport of fertilizers are generally missing from soil profile knowledge bases. A dual-frequency multisensor capacitance probe (MCP) is now commercially available for sandy soils that simultaneously monitor volumetric soil water content (VWC, ') and sa...

Improving streamflow prediction using remotely-sensed soil moisture and snow depth

USDA-ARS?s Scientific Manuscript database

The monitoring of both cold and warm season hydrologic processes in headwater watersheds is critical for accurate water resource monitoring in many alpine regions. This work presents a new method that explores the simultaneous use of remotely sensed surface soil moisture (SM) and snow depth (SD) ret...

Parallel excitation-emission multiplexed fluorescence lifetime confocal microscopy for live cell imaging.

PubMed

Zhao, Ming; Li, Yu; Peng, Leilei

2014-05-05

We present a novel excitation-emission multiplexed fluorescence lifetime microscopy (FLIM) method that surpasses current FLIM techniques in multiplexing capability. The method employs Fourier multiplexing to simultaneously acquire confocal fluorescence lifetime images of multiple excitation wavelength and emission color combinations at 44,000 pixels/sec. The system is built with low-cost CW laser sources and standard PMTs with versatile spectral configuration, which can be implemented as an add-on to commercial confocal microscopes. The Fourier lifetime confocal method allows fast multiplexed FLIM imaging, which makes it possible to monitor multiple biological processes in live cells. The low cost and compatibility with commercial systems could also make multiplexed FLIM more accessible to biological research community.

Ag@4ATP-coated liposomes: SERS traceable delivery vehicles for living cells.

PubMed

Zhu, Dan; Wang, Zhuyuan; Zong, Shenfei; Chen, Hui; Wu, Xin; Pei, Yuwei; Chen, Peng; Ma, Xueqin; Cui, Yiping

2014-07-21

A liposome-Ag nanohybrid has been demonstrated as a SERS traceable intracellular drug nanocarrier. Liposomes have been introduced for their special qualities in drug delivery systems. In essence, 4-aminothiophenol (4ATP) tagged Ag nanoparticles (Ag@4ATP) were adsorbed onto the surfaces of liposomes via electrostatic interactions, in which 4ATP was used as a SERS reporter. In such a nanohybrid, the locations of the carrier can be tracked by SERS signals while those of the drugs can be monitored through their fluorescence, allowing the simultaneous investigation of the intracellular distribution of both the carriers and the drugs. Our experimental results suggest that the reported liposomal system has substantial potential for intracellular drug delivery.

High power microwave components for space communications satellite

NASA Technical Reports Server (NTRS)

Jankowski, H.; Geia, A.

1972-01-01

Analyzed, developed, and tested were high power microwave components for communications satellites systems. Included were waveguide and flange configurations with venting, a harmonic filter, forward and reverse power monitors, electrical fault sensors, and a diplexer for two channel simultaneous transmission. The assembly of 8.36 GHz components was bench tested, and then operated for 60 hours at 3.5 kW CW in a high vacuum. The diplexer was omitted from this test pending a modification of its end irises. An RF leakage test showed only that care is required at flange junctions; all other components were RF tight. Designs were extrapolated for 12 GHz and 2.64 GHz high power satellite systems.

Monitoring Streambed Scour/Deposition Under Nonideal Temperature Signal and Flood Conditions

NASA Astrophysics Data System (ADS)

DeWeese, Timothy; Tonina, Daniele; Luce, Charles

2017-12-01

Streambed erosion and deposition are fundamental geomorphic processes in riverbeds, and monitoring their evolution is important for ecological system management and in-stream infrastructure stability. Previous research showed proof of concept that analysis of paired temperature signals of stream and pore waters can simultaneously provide monitoring scour and deposition, stream sediment thermal regime, and seepage velocity information. However, it did not address challenges often associated with natural systems, including nonideal temperature variations (low-amplitude, nonsinusoidal signal, and vertical thermal gradients) and natural flooding conditions on monitoring scour and deposition processes over time. Here we addressed this knowledge gap by testing the proposed thermal scour-deposition chain (TSDC) methodology, with laboratory experiments to test the impact of nonideal temperature signals under a range of seepage velocities and with a field application during a pulse flood. Both analyses showed excellent match between surveyed and temperature-derived bed elevation changes even under very low temperature signal amplitudes (less than 1°C), nonideal signal shape (sawtooth shape), and strong and changing vertical thermal gradients (4°C/m). Root-mean-square errors on predicting the change in streambed elevations were comparable with the median grain size of the streambed sediment. Future research should focus on improved techniques for temperature signal phase and amplitude extractions, as well as TSDC applications over long periods spanning entire hydrographs.

Automated plasma control with optical emission spectroscopy

NASA Astrophysics Data System (ADS)

Ward, P. P.

Plasma etching and desmear processes for printed wiring board (PWB) manufacture are difficult to predict and control. Non-uniformity of most plasma processes and sensitivity to environmental changes make it difficult to maintain process stability from day to day. To assure plasma process performance, weight loss coupons or post-plasma destructive testing must be used. These techniques are not real-time methods however, and do not allow for immediate diagnosis and process correction. These tests often require scrapping some fraction of a batch to insure the integrity of the rest. Since these tests verify a successful cycle with post-plasma diagnostics, poor test results often determine that a batch is substandard and the resulting parts unusable. These tests are a costly part of the overall fabrication cost. A more efficient method of testing would allow for constant monitoring of plasma conditions and process control. Process anomalies should be detected and corrected before the parts being treated are damaged. Real time monitoring would allow for instantaneous corrections. Multiple site monitoring would allow for process mapping within one system or simultaneous monitoring of multiple systems. Optical emission spectroscopy conducted external to the plasma apparatus would allow for this sort of multifunctional analysis without perturbing the glow discharge. In this paper, optical emission spectroscopy for non-intrusive, in situ process control will be explored along with applications of this technique to for process control, failure analysis and endpoint determination in PWB manufacture.

A clinical evaluation of a remote mobility monitoring system based on SMS messaging.

PubMed

Dalton, Anthony F; Ní Scanaill, Cliodhna; Carew, Sheila; Lyons, Declan; OLaighin, Gearóid

2007-01-01

The objective of this work was to evaluate the accuracy and viability of a mobility telemonitoring system, based on the short message service (SMS), to monitor the functional mobility of elderly subjects in an unsupervised environment. A clinical trial was conducted consisting of 6 elderly subjects; 3 male, 3 female (mean: 81.7, SD: 5.09). Mobility was monitored using an accelerometer based portable unit worn by each monitored subject for eleven hours. Every 15 minutes the mobility of the subject was summarized and transmitted as an SMS message from the portable unit to a remote server for long term analysis. The activPAL Trio Professional physical activity logger was simultaneously used for comparison with the portable unit. On conclusion of the trial each subject completed a questionnaire detailing their satisfaction with the portable unit and any recommendations for improvements. Overall a percentage difference of 2.31% was found between the activPAL Trio and the portable unit for the detection of sitting. For the combined postures of standing and walking the percentage difference was calculated as 2.9%. A bivariate correlation and regression analysis was performed on the entire data set of one subject. Strong positive correlation's were found for the detection of sitting (r = 0.996) and for the combined postures of standing and walking (r = 0.994). Subjects suggested that a lighter, smaller and wireless unit would be more effective.

Lab-on-Skin: A Review of Flexible and Stretchable Electronics for Wearable Health Monitoring.

PubMed

Liu, Yuhao; Pharr, Matt; Salvatore, Giovanni Antonio

2017-10-24

Skin is the largest organ of the human body, and it offers a diagnostic interface rich with vital biological signals from the inner organs, blood vessels, muscles, and dermis/epidermis. Soft, flexible, and stretchable electronic devices provide a novel platform to interface with soft tissues for robotic feedback and control, regenerative medicine, and continuous health monitoring. Here, we introduce the term "lab-on-skin" to describe a set of electronic devices that have physical properties, such as thickness, thermal mass, elastic modulus, and water-vapor permeability, which resemble those of the skin. These devices can conformally laminate on the epidermis to mitigate motion artifacts and mismatches in mechanical properties created by conventional, rigid electronics while simultaneously providing accurate, non-invasive, long-term, and continuous health monitoring. Recent progress in the design and fabrication of soft sensors with more advanced capabilities and enhanced reliability suggest an impending translation of these devices from the research lab to clinical environments. Regarding these advances, the first part of this manuscript reviews materials, design strategies, and powering systems used in soft electronics. Next, the paper provides an overview of applications of these devices in cardiology, dermatology, electrophysiology, and sweat diagnostics, with an emphasis on how these systems may replace conventional clinical tools. The review concludes with an outlook on current challenges and opportunities for future research directions in wearable health monitoring.

Sequential en-face optical coherence tomography imaging and monitoring of Drosophila Melanogaster larval heart

NASA Astrophysics Data System (ADS)

Bradu, A.; Ma, Lisha; Bloor, J.; Podoleanu, A. GH.

2009-02-01

This article demonstrates two modalities to acquire information on cardiac function in larval Drosophila Melanogaster: in-vivo imaging and heartbeat monitoring. To achieve these goals a dedicated imaging instrument able to provide simultaneous en-face Optical Coherence Tomography (OCT) and Laser Scanning Confocal Microscopy (LSCM) images has been developed. With this dual imaging system, the heart can easily be located and visualised within the specimen and the change of the heart shape in a cardiac cycle monitored. The system can easily be switched to a stethoscopic regime, simply by interrupting the scanning of the light beam across the sample, after selecting the point of interest in the imaging regime. Here we have used targeted gene expression to knockdown the myospheroid (mys) gene in the larval heart using a specific RNAi construct. By knocking down a β integrin subunit encoded by mys we have recorded an enlarged heart chamber in both diastolic and systolic states. Also, the fraction of reduction of the chamber diameter was smaller in the knockdown heart. These phenotypic differences indicate that impaired cardiac contractility occurs in the heart where the integrin gene express level is reduced. As far as we are aware, this is for the first time when it is shown in Drosophila that integrins have a direct relationship to a dilated heart defect, and conseqThis article demonstrates two modalities to acquire information on cardiac function in larval Drosophila Melanogaster: in-vivo imaging and heartbeat monitoring. To achieve these goals a dedicated imaging instrument able to provide simultaneous en-face Optical Coherence Tomography (OCT) and Laser Scanning Confocal Microscopy (LSCM) images has been developed. With this dual imaging system, the heart can easily be located and visualised within the specimen and the change of the heart shape in a cardiac cycle monitored. The system can easily be switched to a stethoscopic regime, simply by interrupting the scanning of the light beam across the sample, after selecting the point of interest in the imaging regime. Here we have used targeted gene expression to knockdown the myospheroid (mys) gene in the larval heart using a specific RNAi construct. By knocking down a β integrin subunit encoded by mys we have recorded an enlarged heart chamber in both diastolic and systolic states. Also, the fraction of reduction of the chamber diameter was smaller in the knockdown heart. These phenotypic differences indicate that impaired cardiac contractility occurs in the heart where the integrin gene express level is reduced. As far as we are aware, this is for the first time when it is shown in Drosophila that integrins have a direct relationship to a dilated heart defect, and consequently we demonstrate the utility of Drosophila as model for the study of vertebrate heart disease. By monitoring the heartbeat we also demonstrated a reduction of the heart rate in Tropomyosin mutant compared to the wild type larva.uently we demonstrate the utility of Drosophila as model for the study of vertebrate heart disease. By monitoring the heartbeat we also demonstrated a reduction of the heart rate in Tropomyosin mutant compared to the wild type larva.

Simultaneous multi-patch-clamp and extracellular-array recordings: Single neuron reflects network activity

NASA Astrophysics Data System (ADS)

Vardi, Roni; Goldental, Amir; Sardi, Shira; Sheinin, Anton; Kanter, Ido

2016-11-01

The increasing number of recording electrodes enhances the capability of capturing the network’s cooperative activity, however, using too many monitors might alter the properties of the measured neural network and induce noise. Using a technique that merges simultaneous multi-patch-clamp and multi-electrode array recordings of neural networks in-vitro, we show that the membrane potential of a single neuron is a reliable and super-sensitive probe for monitoring such cooperative activities and their detailed rhythms. Specifically, the membrane potential and the spiking activity of a single neuron are either highly correlated or highly anti-correlated with the time-dependent macroscopic activity of the entire network. This surprising observation also sheds light on the cooperative origin of neuronal burst in cultured networks. Our findings present an alternative flexible approach to the technique based on a massive tiling of networks by large-scale arrays of electrodes to monitor their activity.

Simultaneous multi-patch-clamp and extracellular-array recordings: Single neuron reflects network activity.

PubMed

Vardi, Roni; Goldental, Amir; Sardi, Shira; Sheinin, Anton; Kanter, Ido

2016-11-08

The increasing number of recording electrodes enhances the capability of capturing the network's cooperative activity, however, using too many monitors might alter the properties of the measured neural network and induce noise. Using a technique that merges simultaneous multi-patch-clamp and multi-electrode array recordings of neural networks in-vitro, we show that the membrane potential of a single neuron is a reliable and super-sensitive probe for monitoring such cooperative activities and their detailed rhythms. Specifically, the membrane potential and the spiking activity of a single neuron are either highly correlated or highly anti-correlated with the time-dependent macroscopic activity of the entire network. This surprising observation also sheds light on the cooperative origin of neuronal burst in cultured networks. Our findings present an alternative flexible approach to the technique based on a massive tiling of networks by large-scale arrays of electrodes to monitor their activity.

Simultaneous multi-patch-clamp and extracellular-array recordings: Single neuron reflects network activity

PubMed Central

Vardi, Roni; Goldental, Amir; Sardi, Shira; Sheinin, Anton; Kanter, Ido

2016-01-01

The increasing number of recording electrodes enhances the capability of capturing the network’s cooperative activity, however, using too many monitors might alter the properties of the measured neural network and induce noise. Using a technique that merges simultaneous multi-patch-clamp and multi-electrode array recordings of neural networks in-vitro, we show that the membrane potential of a single neuron is a reliable and super-sensitive probe for monitoring such cooperative activities and their detailed rhythms. Specifically, the membrane potential and the spiking activity of a single neuron are either highly correlated or highly anti-correlated with the time-dependent macroscopic activity of the entire network. This surprising observation also sheds light on the cooperative origin of neuronal burst in cultured networks. Our findings present an alternative flexible approach to the technique based on a massive tiling of networks by large-scale arrays of electrodes to monitor their activity. PMID:27824075

Hybrid Microscopic-Endoscopic Surgery for Craniopharyngioma in Neurosurgical Suite: Technical Notes.

PubMed

Ichikawa, Tomotsugu; Otani, Yoshihiro; Ishida, Joji; Fujii, Kentaro; Kurozumi, Kazuhiko; Ono, Shigeki; Date, Isao

2016-01-01

The best chance of curing craniopharyngioma is achieved by microsurgical total resection; however, its location adjacent to critical structures hinders complete resection without neurologic deterioration. Unrecognized residual tumor within microscopic blind spots might result in tumor recurrences. To improve outcomes, new techniques are necessary to visualize tissue within these blind spots. We examined the success of hybrid microscopic-endoscopic neurosurgery for craniopharyngioma in a neurosurgical suite. Four children with craniopharyngiomas underwent microscopic resection. When the neurosurgeon was confident that most of the visible tumor was removed but was suspicious of residual tumor within the blind spot, he or she used an integrated endoscope-holder system to inspect and remove any residual tumor. Two ceiling monitors were mounted side by side in front of the surgeon to display both microscopic and endoscopic views and to view both monitors simultaneously. Surgery was performed in all patients via the frontobasal interhemispheric approach. Residual tumors were observed in the sella (2 patients), on the ventral surface of the chiasm and optic nerve (1 patient), and in the third ventricle (1 patient) and were resected to achieve total resection. Postoperatively, visual function was improved in 2 patients and none exhibited deterioration related to the surgery. Simultaneous microscopic and endoscopic observation with the use of dual monitors in a neurosurgical suite was ergonomically optimal for the surgeon to perform microsurgical procedures and to avoid traumatizing surrounding vessels or neural tissues. Hybrid microscopic-endoscopic neurosurgery may contribute to safe, less-invasive, and maximal resection to achieve better prognosis in children with craniopharyngioma. Copyright © 2016 Elsevier Inc. All rights reserved.

A Sensitive Dilute-and-Shoot Approach for the Simultaneous Screening of 71 Stimulants and 7 Metabolites in Human Urine by LC-MS-MS with Dynamic MRM.

PubMed

Dong, Ying; Yan, Kuan; Ma, Yanhua; Wang, Shan; He, Genye; Deng, Jing; Yang, Zhiyong

2015-10-01

A novel, reliable and sensitive liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed with dynamic multiple reaction monitoring (dMRM) mode for the simultaneous screening of 71 stimulants and 7 metabolites in human urine using unsophisticated MS instruments (Agilent triple-quadruple 6410 B mass spectrometer). With a known retention time of an analyte, dMRM algorithm monitors each MRM transition only around its expected retention time. Therefore, dMRM enables the maximization of dwell times and provides much higher sensitivity and reproducibility than the conventional multiple reaction monitoring mode (cMRM). After precipitation of protein, the urine sample was injected into LC-MS-MS system directly without sample pre-concentration. For comparison, cMRM and dMRM acquisitions were performed under the same chromatographic conditions. The result showed that the signal response and quality of the chromatograms for each stimulant improved significantly with dMRM over cMRM. The method has been fully validated giving limits of detection (0.1-25 ng/mL) satisfactory for its application to anti-doping analysis. The repeatability of the concentrations and the retention times are good both for intra- and for inter-day experiments (%CV of concentrations always <20 and %CV of retention times <0.5). The method also afforded satisfactory results in terms of accuracy, matrix effect and specificity. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Simultaneous Video-EEG-ECG Monitoring to Identify Neurocardiac Dysfunction in Mouse Models of Epilepsy.

PubMed

Mishra, Vikas; Gautier, Nicole M; Glasscock, Edward

2018-01-29

In epilepsy, seizures can evoke cardiac rhythm disturbances such as heart rate changes, conduction blocks, asystoles, and arrhythmias, which can potentially increase risk of sudden unexpected death in epilepsy (SUDEP). Electroencephalography (EEG) and electrocardiography (ECG) are widely used clinical diagnostic tools to monitor for abnormal brain and cardiac rhythms in patients. Here, a technique to simultaneously record video, EEG, and ECG in mice to measure behavior, brain, and cardiac activities, respectively, is described. The technique described herein utilizes a tethered (i.e., wired) recording configuration in which the implanted electrode on the head of the mouse is hard-wired to the recording equipment. Compared to wireless telemetry recording systems, the tethered arrangement possesses several technical advantages such as a greater possible number of channels for recording EEG or other biopotentials; lower electrode costs; and greater frequency bandwidth (i.e., sampling rate) of recordings. The basics of this technique can also be easily modified to accommodate recording other biosignals, such as electromyography (EMG) or plethysmography for assessment of muscle and respiratory activity, respectively. In addition to describing how to perform the EEG-ECG recordings, we also detail methods to quantify the resulting data for seizures, EEG spectral power, cardiac function, and heart rate variability, which we demonstrate in an example experiment using a mouse with epilepsy due to Kcna1 gene deletion. Video-EEG-ECG monitoring in mouse models of epilepsy or other neurological disease provides a powerful tool to identify dysfunction at the level of the brain, heart, or brain-heart interactions.

SPECTROSCOPIC ONLINE MONITORING FOR PROCESS CONTROL AND SAFEGUARDING OF RADIOCHEMICAL STREAMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bryan, Samuel A.; Levitskaia, Tatiana G.

2013-09-29

There is a renewed interest worldwide to promote the use of nuclear power and close the nuclear fuel cycle. The long term successful use of nuclear power is critically dependent upon adequate and safe processing and disposition of the used nuclear fuel. Liquid-liquid extraction is a separation technique commonly employed for the processing of the dissolved used nuclear fuel. The instrumentation used to monitor these processes must be robust, require little or no maintenance, and be able to withstand harsh environments such as high radiation fields and aggressive chemical matrices. This paper summarizes application of the absorption and vibrational spectroscopicmore » techniques supplemented by physicochemical measurements for radiochemical process monitoring. In this context, our team experimentally assessed the potential of Raman and spectrophotometric techniques for online real-time monitoring of the U(VI)/nitrate ion/nitric acid and Pu(IV)/Np(V)/Nd(III), respectively, in solutions relevant to spent fuel reprocessing. These techniques demonstrate robust performance in the repetitive batch measurements of each analyte in a wide concentration range using simulant and commercial dissolved spent fuel solutions. Spectroscopic measurements served as training sets for the multivariate data analysis to obtain partial least squares predictive models, which were validated using on-line centrifugal contactor extraction tests. Satisfactory prediction of the analytes concentrations in these preliminary experiments warrants further development of the spectroscopy-based methods for radiochemical process control and safeguarding. Additionally, the ability to identify material intentionally diverted from a liquid-liquid extraction contactor system was successfully tested using on-line process monitoring as a means to detect the amount of material diverted. A chemical diversion and detection from a liquid-liquid extraction scheme was demonstrated using a centrifugal contactor system operating with the simulant PUREX extraction system of Nd(NO3)3/nitric acid aqueous phase and TBP/n-dodecane organic phase. During a continuous extraction experiment, a portion of the feed from a counter-current extraction system was diverted while the spectroscopic on-line process monitoring system was simultaneously measuring the feed, raffinate and organic products streams. The amount observed to be diverted by on-line spectroscopic process monitoring was in excellent agreement with values based from the known mass of sample directly taken (diverted) from system feed solution.« less

Simultaneous measurement of liposome extravasation and content release in tumors.

PubMed

Wu, N Z; Braun, R D; Gaber, M H; Lin, G M; Ong, E T; Shan, S; Papahadjopoulos, D; Dewhirst, M W

1997-03-01

The success of liposome-based drug delivery systems for tumor targeting relies on maximum extravasation of liposomes into tumor interstitium, as well as optimal release of contents from the liposomes once within the tumor Liposome extravasation and content release are two separate processes that can be individually or jointly manipulated so a method is needed to monitor these two processes independently and simultaneously. In this report, we describe a method to measure liposome extravasation and content release in tumor tissues growing in a rat skinfold window chamber preparation. Mixtures of liposomes containing either doxorubicin or calcein, both of which are fluorescent, and liposomes surface-labeled with rhodamine were injected intravenously. Fluorescent, light intensities in a tumor region in two fluorescent channels were measured using an image-processing system. Light intensities of plasma from blood samples were also measured using this system. These measurements were used to calculate the amounts of liposomes and released contents in both plasma and tumor interstitium. The calculations were based on the fact that the liposome surface labels and contents emit fluorescent light at different wavelengths and when encapsulated, the contents fluorescence is self-quenched. The model included equations to account for fluorescent light "cross-contamination" by the two fluorochromes as well as equations relating the measured fluorescent light intensities to the amounts of liposomes and released contents. This method was applied to three situations in which liposome extravasation and content release were manipulated in different, predictable ways. Our results indicate that this method can perform simultaneous independent and quantitative measurements of liposome extravasation and content release. This method can potentially be used to study drug delivery of other carrier systems in vivo.

Simultaneous Alcoholic and Malolactic Fermentations by Saccharomyces cerevisiae and Oenococcus oeni Cells Co-immobilized in Alginate Beads

PubMed Central

Bleve, Gianluca; Tufariello, Maria; Vetrano, Cosimo; Mita, Giovanni; Grieco, Francesco

2016-01-01

Malolactic fermentation (MLF) usually takes place after the end of alcoholic fermentation (AF). However, the inoculation of lactic acid bacteria together with yeast starter cultures is a promising system to enhance the quality and safety of wine. In recent years, the use of immobilized cell systems has been investigated, with interesting results, for the production of different fermented foods and beverages. In this study we have carried out the simultaneous immobilization of Saccharomyces cerevisiae and Oenococcus oeni in alginate beads and used them in microvinifications tests to produce Negroamaro wine. The process was monitored by chemical and sensorial analyses and dominance of starters and cell leaking from beads were also checked. Co-immobilization of S. cerevisiae and O. oeni allowed to perform an efficient fermentation process, producing low volatile acidity levels and ethanol and glycerol concentrations comparable with those obtained by cell sequential inoculum and co-inoculum of yeast and bacteria cells in free form. More importantly, co-immobilization strategy produced a significant decrease of the time requested to complete AF and MLF. The immobilized cells could be efficiently reused for the wine fermentation at least three times without any apparent loss of cell metabolic activities. This integrated biocatalytic system is able to perform simultaneously AF and MLF, producing wines similar in organoleptic traits in comparison with wines fermented following traditional sequential AF and MLF with free cell starters. The immobilized-cell system, that we here describe for the first time in our knowledge, offers many advantages over conventional free cell fermentations, including: (i) elimination of non-productive cell growth phases; (ii) feasibility of continuous processing; (iii) re-use of the biocatalyst. PMID:27379072

Time and number of displays impact critical signal detection in fetal heart rate tracings.

PubMed

Anderson, Brittany L; Scerbo, Mark W; Belfore, Lee A; Abuhamad, Alfred Z

2011-06-01

Interest in centralized monitoring in labor and delivery units is growing because it affords the opportunity to monitor multiple patients simultaneously. However, a long history of research on sustained attention reveals these types of monitoring tasks can be problematic. The goal of the present experiment was to examine the ability of individuals to detect critical signals in fetal heart rate (FHR) tracings in one or more displays over an extended period of time. Seventy-two participants monitored one, two, or four computer-simulated FHR tracings on a computer display for the appearance of late decelerations over a 48-minute vigil. Measures of subjective stress and workload were also obtained before and after the vigil. The results showed that detection accuracy decreased over time and also declined as the number of displays increased. The subjective reports indicated that participants found the task to be stressful and mentally demanding, effortful, and frustrating. The results suggest that centralized monitoring that allows many patients to be monitored simultaneously may impose a detrimental attentional burden on the observer. Furthermore, this seemingly benign task may impose an additional source of stress and mental workload above what is commonly found in labor and delivery units. © Thieme Medical Publishers.

A smart health monitoring chair for nonintrusive measurement of biological signals.

PubMed

Baek, Hyun Jae; Chung, Gih Sung; Kim, Ko Keun; Park, Kwang Suk

2012-01-01

We developed nonintrusive methods for simultaneous electrocardiogram, photoplethysmogram, and ballistocardiogram measurements that do not require direct contact between instruments and bare skin. These methods were applied to the design of a diagnostic chair for unconstrained heart rate and blood pressure monitoring purposes. Our methods were operationalized through capacitively coupled electrodes installed in the chair back that include high-input impedance amplifiers, and conductive textiles installed in the seat for capacitive driven-right-leg circuit configuration that is capable of recording electrocardiogram information through clothing. Photoplethysmograms were measured through clothing using seat mounted sensors with specially designed amplifier circuits that vary in light intensity according to clothing type. Ballistocardiograms were recorded using a film type transducer material, polyvinylidenefluoride (PVDF), which was installed beneath the seat cover. By simultaneously measuring signals, beat-to-beat heart rates could be monitored even when electrocardiograms were not recorded due to movement artifacts. Beat-to-beat blood pressure was also monitored using unconstrained measurements of pulse arrival time and other physiological parameters, and our experimental results indicated that the estimated blood pressure tended to coincide with actual blood pressure measurements. This study demonstrates the feasibility of our method and device for biological signal monitoring through clothing for unconstrained long-term daily health monitoring that does not require user awareness and is not limited by physical activity.

Development of a custom on-line ultrasonic vapour analyzer and flow meter for the ATLAS inner detector, with application to Cherenkov and gaseous charged particle detectors

NASA Astrophysics Data System (ADS)

Alhroob, M.; Bates, R.; Battistin, M.; Berry, S.; Bitadze, A.; Bonneau, P.; Bousson, N.; Boyd, G.; Bozza, G.; Crespo-Lopez, O.; Degeorge, C.; Deterre, C.; DiGirolamo, B.; Doubek, M.; Favre, G.; Godlewski, J.; Hallewell, G.; Hasib, A.; Katunin, S.; Langevin, N.; Lombard, D.; Mathieu, M.; McMahon, S.; Nagai, K.; O'Rourke, A.; Pearson, B.; Robinson, D.; Rossi, C.; Rozanov, A.; Strauss, M.; Vacek, V.; Zwalinski, L.

2015-03-01

Precision sound velocity measurements can simultaneously determine binary gas composition and flow. We have developed an analyzer with custom microcontroller-based electronics, currently used in the ATLAS Detector Control System, with numerous potential applications. Three instruments monitor C3F8 and CO2 coolant leak rates into the nitrogen envelopes of the ATLAS silicon microstrip and Pixel detectors. Two further instruments will aid operation of the new thermosiphon coolant recirculator: one of these will monitor air leaks into the low pressure condenser while the other will measure return vapour flow along with C3F8/C2F6 blend composition, should blend operation be necessary to protect the ATLAS silicon tracker under increasing LHC luminosity. We describe these instruments and their electronics.

Simultaneous recording of EEG and electromyographic polygraphy increases the diagnostic yield of video-EEG monitoring.

PubMed

Hill, Aron T; Briggs, Belinda A; Seneviratne, Udaya

2014-06-01

To investigate the usefulness of adjunctive electromyographic (EMG) polygraphy in the diagnosis of clinical events captured during long-term video-EEG monitoring. A total of 40 patients (21 women, 19 men) aged between 19 and 72 years (mean 43) investigated using video-EEG monitoring were studied. Electromyographic activity was simultaneously recorded with EEG in four patients selected on clinical grounds. In these patients, surface EMG electrodes were placed over muscles suspected to be activated during a typical clinical event. Of the 40 patients investigated, 24 (60%) were given a diagnosis, whereas 16 (40%) remained undiagnosed. All four patients receiving adjunctive EMG polygraphy obtained a diagnosis, with three of these diagnoses being exclusively reliant on the EMG recordings. Specifically, one patient was diagnosed with propriospinal myoclonus, another patient was diagnosed with facio-mandibular myoclonus, and a third patient was found to have bruxism and periodic leg movements of sleep. The information obtained from surface EMG recordings aided the diagnosis of clinical events captured during video-EEG monitoring in 7.5% of the total cohort. This study suggests that EEG-EMG polygraphy may be used as a technique of improving the diagnostic yield of video-EEG monitoring in selected cases.

The validity of activity monitors for measuring sleep in elite athletes.

PubMed

Sargent, Charli; Lastella, Michele; Halson, Shona L; Roach, Gregory D

2016-10-01

There is a growing interest in monitoring the sleep of elite athletes. Polysomnography is considered the gold standard for measuring sleep, however this technique is impractical if the aim is to collect data simultaneously with multiple athletes over consecutive nights. Activity monitors may be a suitable alternative for monitoring sleep, but these devices have not been validated against polysomnography in a population of elite athletes. Participants (n=16) were endurance-trained cyclists participating in a 6-week training camp. A total of 122 nights of sleep were recorded with polysomnography and activity monitors simultaneously. Agreement, sensitivity, and specificity were calculated from epoch-for-epoch comparisons of polysomnography and activity monitor data. Sleep variables derived from polysomnography and activity monitors were compared using paired t-tests. Activity monitor data were analysed using low, medium, and high sleep-wake thresholds. Epoch-for-epoch comparisons showed good agreement between activity monitors and polysomnography for each sleep-wake threshold (81-90%). Activity monitors were sensitive to sleep (81-92%), but specificity differed depending on the threshold applied (67-82%). Activity monitors underestimated sleep duration (18-90min) and overestimated wake duration (4-77min) depending on the threshold applied. Applying the correct sleep-wake threshold is important when using activity monitors to measure the sleep of elite athletes. For example, the default sleep-wake threshold (>40 activity counts=wake) underestimates sleep duration by ∼50min and overestimates wake duration by ∼40min. In contrast, sleep-wake thresholds that have a high sensitivity to sleep (>80 activity counts=wake) yield the best combination of agreement, sensitivity, and specificity. Copyright © 2015 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Ultra-performance liquid chromatography tandem mass-spectrometry (uplc-ms/ms) for the rapid, simultaneous analysis of thiamin, riboflavin, flavin adenine dinucleotide, nicotinamide and pyridoxal in human milk

USDA-ARS?s Scientific Manuscript database

A novel, rapid and sensitive Ultra Performance Liquid-Chromatography tandem Mass-Spectrometry (UPLC-MS/MS) method for the simultaneous determination of several B-vitamins in human milk was developed. Resolution by retention time or multiple reaction monitoring (MRM) for thiamin, riboflavin, flavin a...

A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Xi; Huang, Xiaobiao

2016-05-13

Here, we propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. The fitting results are used for lattice correction. Finally, the method has been successfully demonstrated on the NSLS-II storage ring.

A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Xi; Huang, Xiaobiao

2016-08-01

We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. Furthermore, the fitting results are used for lattice correction. Our method has been successfully demonstrated on the NSLS-II storage ring.

A method for simultaneous linear optics and coupling correction for storage rings with turn-by-turn beam position monitor data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Xi; Huang, Xiaobiao

2016-08-01

We propose a method to simultaneously correct linear optics errors and linear coupling for storage rings using turn-by-turn (TbT) beam position monitor (BPM) data. The independent component analysis (ICA) method is used to isolate the betatron normal modes from the measured TbT BPM data. The betatron amplitudes and phase advances of the projections of the normal modes on the horizontal and vertical planes are then extracted, which, combined with dispersion measurement, are used to fit the lattice model. The fitting results are used for lattice correction. The method has been successfully demonstrated on the NSLS-II storage ring.

A-TEEMTM, a new molecular fingerprinting technique: simultaneous absorbance-transmission and fluorescence excitation-emission matrix method

NASA Astrophysics Data System (ADS)

Quatela, Alessia; Gilmore, Adam M.; Steege Gall, Karen E.; Sandros, Marinella; Csatorday, Karoly; Siemiarczuk, Alex; (Ben Yang, Boqian; Camenen, Loïc

2018-04-01

We investigate the new simultaneous absorbance-transmission and fluorescence excitation-emission matrix method for rapid and effective characterization of the varying components from a mixture. The absorbance-transmission and fluorescence excitation-emission matrix method uniquely facilitates correction of fluorescence inner-filter effects to yield quantitative fluorescence spectral information that is largely independent of component concentration. This is significant because it allows one to effectively monitor quantitative component changes using multivariate methods and to generate and evaluate spectral libraries. We present the use of this novel instrument in different fields: i.e. tracking changes in complex mixtures including natural water, wine as well as monitoring stability and aggregation of hormones for biotherapeutics.

Towards real-time regional earthquake simulation I: real-time moment tensor monitoring (RMT) for regional events in Taiwan

NASA Astrophysics Data System (ADS)

Lee, Shiann-Jong; Liang, Wen-Tzong; Cheng, Hui-Wen; Tu, Feng-Shan; Ma, Kuo-Fong; Tsuruoka, Hiroshi; Kawakatsu, Hitoshi; Huang, Bor-Shouh; Liu, Chun-Chi

2014-01-01

We have developed a real-time moment tensor monitoring system (RMT) which takes advantage of a grid-based moment tensor inversion technique and real-time broad-band seismic recordings to automatically monitor earthquake activities in the vicinity of Taiwan. The centroid moment tensor (CMT) inversion technique and a grid search scheme are applied to obtain the information of earthquake source parameters, including the event origin time, hypocentral location, moment magnitude and focal mechanism. All of these source parameters can be determined simultaneously within 117 s after the occurrence of an earthquake. The monitoring area involves the entire Taiwan Island and the offshore region, which covers the area of 119.3°E to 123.0°E and 21.0°N to 26.0°N, with a depth from 6 to 136 km. A 3-D grid system is implemented in the monitoring area with a uniform horizontal interval of 0.1° and a vertical interval of 10 km. The inversion procedure is based on a 1-D Green's function database calculated by the frequency-wavenumber (fk) method. We compare our results with the Central Weather Bureau (CWB) catalogue data for earthquakes occurred between 2010 and 2012. The average differences between event origin time and hypocentral location are less than 2 s and 10 km, respectively. The focal mechanisms determined by RMT are also comparable with the Broadband Array in Taiwan for Seismology (BATS) CMT solutions. These results indicate that the RMT system is realizable and efficient to monitor local seismic activities. In addition, the time needed to obtain all the point source parameters is reduced substantially compared to routine earthquake reports. By connecting RMT with a real-time online earthquake simulation (ROS) system, all the source parameters will be forwarded to the ROS to make the real-time earthquake simulation feasible. The RMT has operated offline (2010-2011) and online (since January 2012 to present) at the Institute of Earth Sciences (IES), Academia Sinica (http://rmt.earth.sinica.edu.tw). The long-term goal of this system is to provide real-time source information for rapid seismic hazard assessment during large earthquakes.

Multi-detector system approach for unattended uranium enrichment monitoring at gas centrifuge enrichment plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Favalli, A.; Lombardi, M.; MacArthur, D. W.

Improving the quality of safeguards measurements at Gas Centrifuge Enrichment Plants while reducing the inspection effort is an important objective given the number of existing and new plants that need to be safeguarded. A useful tool in many safeguards approaches is the on-line monitoring of enrichment in process pipes. One requirement of such a monitor is a simple, reliable and precise passive measurement of the 186-keV line from 235U. The other information required is the amount of gas in the pipe, which can be obtained by a transmission or pressure measurement. Here, we describe our research to develop such amore » passive measurement system. Unfortunately, a complication arises in the interpretation of the gamma measurements, from the contribution of uranium deposits on the wall of the pipe to the 186-keV peak. A multi-detector approach to address this complication is presented where two measurements, one with signal primarily from gas and one with signal primarily from deposits, are performed simultaneously with different detectors and geometries. This allows a correction to be made to the 186-keV peak for the contribution from the deposit. Finally, we present the design of the multi-detector system and the results of the experimental calibration of the proof-of-principle prototype built at LANL.« less

Near-real-time combustion monitoring for PCDD/PCDF indicators by GC-REMPI-TOFMS.

PubMed

Gullett, Brian K; Oudejans, Lukas; Tabor, Dennis; Touati, Abderrahmane; Ryan, Shawn

2012-01-17

The boiler exit flue gas of a municipal waste combustor was sampled to evaluate an online monitoring system for chlorobenzene congeners as indicators of polychlorinated dibenzodioxin and dibenzofuran (PCDD/PCDF) concentrations. Continuous measurements of chlorobenzene congeners using gas chromatography coupled to a resonance-enhanced multiphoton ionization - time-of-flight mass spectrometry (GC-REMPI-TOFMS) system were compared over 5-min periods with conventional sampling methods for PCDD/PCDF. Three pairs of values were taken every hour over a period of three days to characterize the combustor's response to transient operating conditions (shutdowns and startups). Isolation of specific chlorobenzene congeners from other same-mass compounds was accomplished by using a GC column separator ahead of the REMPI-TOFMS. The 50-fold variation of PCDD/PCDF concentration was paralleled by similar changes in monitored compounds of 1,4-dichlorobenzene, 1,2,4-trichlorobenzene, 1,2,3-trichlorobenzene, and 1,2,4,5-tetrachlorobenzene. A correlation of R = 0.85 and 0.89 was established between 40 pairs of simultaneous 5-min GC-REMPI-TOFMS measurements of 1,2,4-trichlorobenzene and 5 min conventional sampling and analysis for the TEQ and Total measures of PCDD/PCDF, respectively. The GC-REMPI-TOFMS system can be used to provide frequent measures of correlative PCDD/PCDF concentration thereby allowing for an understanding of measures to minimize PCDD/PCDF formation and develop operational feedback to limit emissions.

Real-time three-dimensional digital image correlation for biomedical applications

NASA Astrophysics Data System (ADS)

Wu, Rong; Wu, Hua; Arola, Dwayne; Zhang, Dongsheng

2016-10-01

Digital image correlation (DIC) has been successfully applied for evaluating the mechanical behavior of biological tissues. A three-dimensional (3-D) DIC system has been developed and applied to examining the motion of bones in the human foot. To achieve accurate, real-time displacement measurements, an algorithm including matching between sequential images and image pairs has been developed. The system was used to monitor the movement of markers which were attached to a precisely motorized stage. The accuracy of the proposed technique for in-plane and out-of-plane measurements was found to be -0.25% and 1.17%, respectively. Two biomedical applications were presented. In the experiment involving the foot arch, a human cadaver lower leg and foot specimen were subjected to vertical compressive loads up to 700 N at a rate of 10 N/s and the 3-D motions of bones in the foot were monitored in real time. In the experiment involving distal tibio fibular syndesmosis, a human cadaver lower leg and foot specimen were subjected to a monotonic rotational torque up to 5 Nm at a speed of 5 deg per min and the relative displacements of the tibia and fibula were monitored in real time. Results showed that the system could reach a frequency of up to 16 Hz with 6 points measured simultaneously. This technique sheds new lights on measuring 3-D motion of bones in biomechanical studies.

Multi-detector system approach for unattended uranium enrichment monitoring at gas centrifuge enrichment plants

DOE PAGES

Favalli, A.; Lombardi, M.; MacArthur, D. W.; ...

2017-09-14

Improving the quality of safeguards measurements at Gas Centrifuge Enrichment Plants while reducing the inspection effort is an important objective given the number of existing and new plants that need to be safeguarded. A useful tool in many safeguards approaches is the on-line monitoring of enrichment in process pipes. One requirement of such a monitor is a simple, reliable and precise passive measurement of the 186-keV line from 235U. The other information required is the amount of gas in the pipe, which can be obtained by a transmission or pressure measurement. Here, we describe our research to develop such amore » passive measurement system. Unfortunately, a complication arises in the interpretation of the gamma measurements, from the contribution of uranium deposits on the wall of the pipe to the 186-keV peak. A multi-detector approach to address this complication is presented where two measurements, one with signal primarily from gas and one with signal primarily from deposits, are performed simultaneously with different detectors and geometries. This allows a correction to be made to the 186-keV peak for the contribution from the deposit. Finally, we present the design of the multi-detector system and the results of the experimental calibration of the proof-of-principle prototype built at LANL.« less

Occupancy models for monitoring marine fish: a bayesian hierarchical approach to model imperfect detection with a novel gear combination.

PubMed

Coggins, Lewis G; Bacheler, Nathan M; Gwinn, Daniel C

2014-01-01

Occupancy models using incidence data collected repeatedly at sites across the range of a population are increasingly employed to infer patterns and processes influencing population distribution and dynamics. While such work is common in terrestrial systems, fewer examples exist in marine applications. This disparity likely exists because the replicate samples required by these models to account for imperfect detection are often impractical to obtain when surveying aquatic organisms, particularly fishes. We employ simultaneous sampling using fish traps and novel underwater camera observations to generate the requisite replicate samples for occupancy models of red snapper, a reef fish species. Since the replicate samples are collected simultaneously by multiple sampling devices, many typical problems encountered when obtaining replicate observations are avoided. Our results suggest that augmenting traditional fish trap sampling with camera observations not only doubled the probability of detecting red snapper in reef habitats off the Southeast coast of the United States, but supplied the necessary observations to infer factors influencing population distribution and abundance while accounting for imperfect detection. We found that detection probabilities tended to be higher for camera traps than traditional fish traps. Furthermore, camera trap detections were influenced by the current direction and turbidity of the water, indicating that collecting data on these variables is important for future monitoring. These models indicate that the distribution and abundance of this species is more heavily influenced by latitude and depth than by micro-scale reef characteristics lending credence to previous characterizations of red snapper as a reef habitat generalist. This study demonstrates the utility of simultaneous sampling devices, including camera traps, in aquatic environments to inform occupancy models and account for imperfect detection when describing factors influencing fish population distribution and dynamics.

Occupancy Models for Monitoring Marine Fish: A Bayesian Hierarchical Approach to Model Imperfect Detection with a Novel Gear Combination

PubMed Central

Coggins, Lewis G.; Bacheler, Nathan M.; Gwinn, Daniel C.

2014-01-01

Occupancy models using incidence data collected repeatedly at sites across the range of a population are increasingly employed to infer patterns and processes influencing population distribution and dynamics. While such work is common in terrestrial systems, fewer examples exist in marine applications. This disparity likely exists because the replicate samples required by these models to account for imperfect detection are often impractical to obtain when surveying aquatic organisms, particularly fishes. We employ simultaneous sampling using fish traps and novel underwater camera observations to generate the requisite replicate samples for occupancy models of red snapper, a reef fish species. Since the replicate samples are collected simultaneously by multiple sampling devices, many typical problems encountered when obtaining replicate observations are avoided. Our results suggest that augmenting traditional fish trap sampling with camera observations not only doubled the probability of detecting red snapper in reef habitats off the Southeast coast of the United States, but supplied the necessary observations to infer factors influencing population distribution and abundance while accounting for imperfect detection. We found that detection probabilities tended to be higher for camera traps than traditional fish traps. Furthermore, camera trap detections were influenced by the current direction and turbidity of the water, indicating that collecting data on these variables is important for future monitoring. These models indicate that the distribution and abundance of this species is more heavily influenced by latitude and depth than by micro-scale reef characteristics lending credence to previous characterizations of red snapper as a reef habitat generalist. This study demonstrates the utility of simultaneous sampling devices, including camera traps, in aquatic environments to inform occupancy models and account for imperfect detection when describing factors influencing fish population distribution and dynamics. PMID:25255325

Hyperspectral techniques in analysis of oral dosage forms.

PubMed

Hamilton, Sara J; Lowell, Amanda E; Lodder, Robert A

2002-10-01

Pharmaceutical oral dosage forms are used in this paper to test the sensitivity and spatial resolution of hyperspectral imaging instruments. The first experiment tested the hypothesis that a near-infrared (IR) tunable diode-based remote sensing system is capable of monitoring degradation of hard gelatin capsules at a relatively long distance (0.5 km). Spectra from the capsules were used to differentiate among capsules exposed to an atmosphere containing 150 ppb formaldehyde for 0, 2, 4, and 8 h. Robust median-based principal component regression with Bayesian inference was employed for outlier detection. The second experiment tested the hypothesis that near-IR imaging spectrometry of tablets permits the identification and composition of multiple individual tablets to be determined simultaneously. A near-IR camera was used to collect thousands of spectra simultaneously from a field of blister-packaged tablets. The number of tablets that a typical near-IR camera can currently analyze simultaneously was estimated to be approximately 1300. The bootstrap error-adjusted single-sample technique chemometric-imaging algorithm was used to draw probability-density contour plots that revealed tablet composition. The single-capsule analysis provides an indication of how far apart the sample and instrumentation can be and still maintain adequate signal-to-noise ratio (S/N), while the multiple-tablet imaging experiment gives an indication of how many samples can be analyzed simultaneously while maintaining an adequate S/N and pixel coverage on each sample.

Simultaneous Application of Fibrous Piezoresistive Sensors for Compression and Traction Detection in Glass Laminate Composites

PubMed Central

Nauman, Saad; Cristian, Irina; Koncar, Vladan

2011-01-01

This article describes further development of a novel Non Destructive Evaluation (NDE) approach described in one of our previous papers. Here these sensors have been used for the first time as a Piecewise Continuous System (PCS), which means that they are not only capable of following the deformation pattern but can also detect distinctive fracture events. In order to characterize the simultaneous compression and traction response of these sensors, multilayer glass laminate composite samples were prepared for 3-point bending tests. The laminate sample consisted of five layers of plain woven glass fabrics placed one over another. The sensors were placed at two strategic locations during the lay-up process so as to follow traction and compression separately. The reinforcements were then impregnated in epoxy resin and later subjected to 3-point bending tests. An appropriate data treatment and recording device has also been developed and used for simultaneous data acquisition from the two sensors. The results obtained, under standard testing conditions have shown that our textile fibrous sensors can not only be used for simultaneous detection of compression and traction in composite parts for on-line structural health monitoring but their sensitivity and carefully chosen location inside the composite ensures that each fracture event is indicated in real time by the output signal of the sensor. PMID:22163707

Simultaneous application of fibrous piezoresistive sensors for compression and traction detection in glass laminate composites.

PubMed

Nauman, Saad; Cristian, Irina; Koncar, Vladan

2011-01-01

This article describes further development of a novel Non Destructive Evaluation (NDE) approach described in one of our previous papers. Here these sensors have been used for the first time as a Piecewise Continuous System (PCS), which means that they are not only capable of following the deformation pattern but can also detect distinctive fracture events. In order to characterize the simultaneous compression and traction response of these sensors, multilayer glass laminate composite samples were prepared for 3-point bending tests. The laminate sample consisted of five layers of plain woven glass fabrics placed one over another. The sensors were placed at two strategic locations during the lay-up process so as to follow traction and compression separately. The reinforcements were then impregnated in epoxy resin and later subjected to 3-point bending tests. An appropriate data treatment and recording device has also been developed and used for simultaneous data acquisition from the two sensors. The results obtained, under standard testing conditions have shown that our textile fibrous sensors can not only be used for simultaneous detection of compression and traction in composite parts for on-line structural health monitoring but their sensitivity and carefully chosen location inside the composite ensures that each fracture event is indicated in real time by the output signal of the sensor.

Evaluation of a minimally invasive system for measuring glucose area under the curve during oral glucose tolerance tests: usefulness of sweat monitoring for precise measurement.

PubMed

Sakaguchi, Kazuhiko; Hirota, Yushi; Hashimoto, Naoko; Ogawa, Wataru; Hamaguchi, Tomoya; Matsuo, Toshihiro; Miyagawa, Jun-ichiro; Namba, Mitsuyoshi; Sato, Toshiyuki; Okada, Seiki; Tomita, Koji; Matsuhisa, Munehide; Kaneto, Hideaki; Kosugi, Keisuke; Maegawa, Hiroshi; Nakajima, Hiromu; Kashiwagi, Atsunori

2013-05-01

We developed a system for measuring glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET). Sweat contamination during interstitial fluid glucose (IG) extraction affects the accuracy of glucose AUC measurement, because this technology uses extracted sodium ion levels as an internal standard. Therefore, we developed a sweat monitoring patch to reduce this effect and investigated its efficacy in volunteers undergoing oral glucose tolerance tests (OGTTs). Fifty diabetes mellitus inpatients and 10 healthy subjects undergoing the 75 g OGTT were included. Two sites on the forearm were pretreated with microneedle arrays, then hydrogels for interstitial fluid extraction were placed on the treated sites. Simultaneously, hydrogels for sweat monitoring were placed on untreated sites near the treated sites. Plasma glucose (PG) levels were measured every 30 min for 2 h to calculate reference AUC values. Using MIET, IG AUC was calculated from extracted glucose and sodium ion levels after attachment of the hydrogel for 2 h. Good correlation between IG AUC measurements using MIET and reference AUCs measured using PG levels was confirmed over a wide AUC range (202-610 mg/h/dl) after correction for the sweat-induced error detected by the hydrogel patches on the nonpretreated skin. Strong correlation between IG AUC and peak glucose levels indicates that glucose spikes can be easily detected by this system. We confirmed the effectiveness of a sweat monitoring patch for precise AUC measurement using MIET. This novel, easy-to-use system has potential for glucose excursion evaluation in daily clinical practice. © 2013 Diabetes Technology Society.

Evaluation of a Minimally Invasive System for Measuring Glucose Area under the Curve during Oral Glucose Tolerance Tests: Usefulness of Sweat Monitoring for Precise Measurement

PubMed Central

Sakaguchi, Kazuhiko; Hirota, Yushi; Hashimoto, Naoko; Ogawa, Wataru; Hamaguchi, Tomoya; Toshihiro, Matsuo; Miyagawa, Jun-ichiro; Namba, Mitsuyoshi; Sato, Toshiyuki; Okada, Seiki; Tomita, Koji; Matsuhisa, Munehide; Kaneto, Hideaki; Kosugi, Keisuke; Maegawa, Hiroshi; Nakajima, Hiromu; Kashiwagi, Atsunori

2013-01-01

Aims: We developed a system for measuring glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET). Sweat contamination during interstitial fluid glucose (IG) extraction affects the accuracy of glucose AUC measurement, because this technology uses extracted sodium ion levels as an internal standard. Therefore, we developed a sweat monitoring patch to reduce this effect and investigated its efficacy in volunteers undergoing oral glucose tolerance tests (OGTTs). Materials and Methods: Fifty diabetes mellitus inpatients and 10 healthy subjects undergoing the 75 g OGTT were included. Two sites on the forearm were pretreated with microneedle arrays, then hydrogels for interstitial fluid extraction were placed on the treated sites. Simultaneously, hydrogels for sweat monitoring were placed on untreated sites near the treated sites. Plasma glucose (PG) levels were measured every 30 min for 2 h to calculate reference AUC values. Using MIET, IG AUC was calculated from extracted glucose and sodium ion levels after attachment of the hydrogel for 2 h. Results: Good correlation between IG AUC measurements using MIET and reference AUCs measured using PG levels was confirmed over a wide AUC range (202–610 mg/h/dl) after correction for the sweat-induced error detected by the hydrogel patches on the nonpretreated skin. Strong correlation between IG AUC and peak glucose levels indicates that glucose spikes can be easily detected by this system. Conclusion: We confirmed the effectiveness of a sweat monitoring patch for precise AUC measurement using MIET. This novel, easy-to-use system has potential for glucose excursion evaluation in daily clinical practice. PMID:23759401

Multi-level Simulation of a Real Time Vibration Monitoring System Component

NASA Technical Reports Server (NTRS)

Robertson, Bryan A.; Wilkerson, Delisa

2005-01-01

This paper describes the development of a custom built Digital Signal Processing (DSP) printed circuit board designed to implement the Advanced Real Time Vibration Monitoring Subsystem proposed by Marshall Space Flight Center (MSFC) Transportation Directorate in 2000 for the Space Shuttle Main Engine Advanced Health Management System (AHMS). This Real Time Vibration Monitoring System (RTVMS) is being developed for ground use as part of the AHMS Health Management Computer-Integrated Rack Assembly (HMC-IRA). The HMC-IRA RTVMS design contains five DSPs which are highly interconnected through individual communication ports, shared memory, and a unique communication router that allows all the DSPs to receive digitized data fiom two multi-channel analog boards simultaneously. This paper will briefly cover the overall board design but will focus primarily on the state-of-the-art simulation environment within which this board was developed. This 16-layer board with over 1800 components and an additional mezzanine card has been an extremely challenging design. Utilization of a Mentor Graphics simulation environment provided the unique board and system level simulation capability to ascertain any timing or functional concerns before production. By combining VHDL, Synopsys Software and Hardware Models, and the Mentor Design Capture Environment, multiple simulations were developed to verify the RTVMS design. This multi-level simulation allowed the designers to achieve complete operability without error the first time the RTVMS printed circuit board was powered. The HMC-IRA design has completed all engineering and deliverable unit testing. P

Monitoring the ionosphere during the earthquake on GPS data

NASA Astrophysics Data System (ADS)

Smirnov, V. M.; Smirnova, E. V.

The problem of stability estimation of physical state of an atmosphere attracts a rapt attention of the world community but it is still far from being solved A lot of global atmospheric processes which have direct influence upon all forms of the earth life have been detected The comprehension of cause effect relations stipulating their origin and development is possible only on the basis of long-term sequences of observations data of time-space variations of the atmosphere characteristics which should be received on a global scale and in the interval of altitudes as brand as possible Such data can be obtained only with application satellite systems The latest researches have shown that the satellite systems can be successfully used for global and continuous monitoring ionosphere of the Earth In turn the ionosphere can serve a reliable indicator of different kinds of effects on an environment both of natural and anthropogenic origin Nowadays the problem of the short-term forecast of earthquakes has achieved a new level of understanding There have been revealed indisputable factors which show that the ionosphere anomalies observed during the preparation of seismic events contain the information allowing to detect and to interpret them as earthquake precursors The partial decision of the forecast problem of earthquakes on ionospheric variations requires the processing data received simultaneously from extensive territories Such requirements can be met only on the basis of ground-space system of ionosphere monitoring The navigating systems

Multi-level Simulation of a Real Time Vibration Monitoring System Component

NASA Technical Reports Server (NTRS)

Roberston, Bryan; Wilkerson, DeLisa

2004-01-01

This paper describes the development of a custom built Digital Signal Processing (DSP) printed circuit board designed to implement the Advanced Real Time Vibration Monitoring Subsystem proposed by MSFC Transportation Directorate in 2000 for the Space Shuttle Main Engine Advanced Health Management System (AHMS). This Real Time Vibration Monitoring System (RTVMS) is being developed for ground use as part of the AHMS Health Management Computer-Integrated Rack Assembly (HMC-IRA). The HMC-IRA RTVMS design contains five DSPs which are highly interconnected through individual communication ports, shared memory, and a unique communication router that allows all the DSPs to receive digitized data from two multi-channel analog boards simultaneously. This paper will briefly cover the overall board design but will focus primarily on the state-of-the-art simulation environment within which this board was developed. This 16-layer board with over 1800 components and an additional mezzanine card has been an extremely challenging design. Utilization of a Mentor Graphics simulation environment provided the unique board and system level simulation capability to ascertain any timing or functional concerns before production. By combining VHDL, Synopsys Software and Hardware Models, and the Mentor Design Capture Environment, multiple simulations were developed to verify the RTVMS design. This multi-level simulation allowed the designers to achieve complete operability without error the first time the RTVMS printed circuit board was powered. The HMCIRA design has completed all engineering unit testing and the deliverable unit is currently under development.

Real-time Cure Monitoring of Composites Using a Guided wave-based System with High Temperature Piezoelectric Transducers, Fiber Bragg Gratings, and Phase-shifted Fiber Bragg Gratings

NASA Astrophysics Data System (ADS)

Hudson, Tyler Blake

An in-process, in-situ cure monitoring technique utilizing a guided wave-based concept for carbon fiber reinforced polymer (CFRP) composites was investigated. Two automated cure monitoring systems using guided-wave ultrasonics were developed for characterizing the state of the cure. In the first system, surface mounted high-temperature piezoelectric transducer arrays were employed for actuation and sensing. The second system motivated by the success of the first system includes a single piezoelectric disc, bonded onto the surface of the composite for excitation; fiber Bragg gratings (FBGs) and/or phase-shifted fiber Bragg gratings (PSFBGs) were embedded in the composite for distributed cure sensing. Composite material properties (viscosity and degree of cure) evolved during cure of the panels fabricated from HexcelRTM IM7/8552 prepreg correlated well to the amplitude, time of arrival, and group velocity of the guided wave-based measurements during the cure cycle. In addition, key phase transitions (gelation and vitrification) were clearly identified from the experimental data during the same cure cycle. The material properties and phase transitions were validated using cure process modeling software (e.g., RAVENRTM). The high-temperature piezoelectric transducer array system demonstrated the feasibility of a guided wave-based, in-process, cure monitoring and provided the framework for defect detection during cure. Ultimately, this system could provide a traceable data stream for non-compliance investigations during serial production and perform closed-loop process control to maximize composite panel quality and consistency. In addition, this system could be deployed as a "smart" caul/tool plate to existing production lines without changing the design of the aircraft/structure. With the second system, strain in low frequency (quasi-static) and the guided wavebased signals in several hundred kilohertz range were measured almost simultaneously using the same FBG or PS-FBG throughout the cure cycle. Also, the residual strain can be readily determined at the end of the cure. This system demonstrated a real-time, in-situ, cure monitoring system using embedded multiplexed FBG/PS-FBG sensors to record both guided wave-based signals and strain. The distinct advantages of a fiber optic-based system include multiplexing, small size, embedding, utilization in harsh environments, electrically passive operation, and electromagnetic interference (EMI) immunity. The embedded multiplexed FBG/PS-FBG fiber optic sensor can monitor the entire life-cycle of the composite structure from curing, post-cure/assembly, and in-service for creating "smart structures".

Development of a 300°C 3C Fiber Optic Downhole Seismic Receiver Array for Surveying and Monitoring of Geothermal Reservoirs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paulsson, Bjorn N.P.

2016-06-29

To address the critical site characterization and monitoring needs for Enhance Geothermal Systems (EGS) programs, US Department of Energy (DOE) awarded Paulsson, Inc. in 2011 a contract to design, build and test a high temperature fiber optic based ultra-large bandwidth clamped borehole seismic vector array capable of deploying a large number of 3C sensor pods suitable for deployment into high temperature and high pressure boreholes. Paulsson, Inc. has completed a design or a unique borehole seismic system consisting of a novel drill pipe based deployment system that includes a hydraulic clamping mechanism for the sensor pods, a new sensor podmore » design and most important – a unique fiber optic seismic vector sensor with technical specifications and capabilities that far exceed the state of the art seismic sensor technologies. These novel technologies were all applied to the new borehole seismic system. In combination these technologies will allow for the deployment of up to 1,000 3C sensor pods in vertical, deviated or horizontal wells. Laboratory tests of the fiber optic seismic vector sensors developed during this project have shown that the new borehole seismic sensor technology is capable of generating outstanding high vector fidelity data with extremely large bandwidth: 0.01 – 6,000 Hz. Field tests have shown that the system can record events at magnitudes much smaller than M-4.0 at frequencies over 2,000 Hz. The sensors have also proved to be about 100 times more sensitive than the regular coil geophones that are used in borehole seismic systems today. The fiber optic seismic sensors have furthermore been qualified to operate at temperatures over 300°C (572°F). The data telemetry fibers used for the seismic vector sensors in the system are also used to simultaneously record Distributed Temperature Sensor (DTS) and Distributed Acoustic Sensor (DAS) data allowing additional value added data to be recorded simultaneously with the seismic vector sensor data.« less

Minimally invasive evacuation of parenchymal and ventricular hemorrhage using the Apollo system with simultaneous neuronavigation, neuroendoscopy and active monitoring with cone beam CT.

PubMed

Fiorella, David; Gutman, Fredrick; Woo, Henry; Arthur, Adam; Aranguren, Ricardo; Davis, Raphael

2015-10-01

The Apollo system is a low profile irrigation-aspiration system which can be used for the evacuation of intracranial hemorrhage. We demonstrate the feasibility of using Apollo to evacuate intracranial hemorrhage in a series of three patients with combined neuronavigation, neuroendoscopy, and cone beam CT (CB-CT). Access to the hematoma was planned using neuronavigation software. Parietal (n=2) or frontal (1) burr holes were created and a 19 F endoscopic sheath was placed under neuronavigation guidance into the distal aspect of the hematoma along its longest accessible axis. The 2.6 mm Apollo wand was then directed through the working channel of a neuroendoscope and used to aspirate the blood products under direct visualization, working from distal to proximal. After a pass through the hematoma, the sheath, neuroendoscope, and Apollo system were removed. CB-CT was then used to evaluate for residual hematoma. When required, the CB-CT data could then be directly uploaded into the neuronavigation system and a new trajectory planned to approach the residual hematoma. Three patients with parenchymal (n=2) and mixed parenchymal-intraventricular (n=1) hematomas underwent minimally invasive evacuation with the Apollo system. The isolated parenchymal hematomas measured 93.4 and 15.6 mL and were reduced to 11.2 (two passes) and 0.9 mL (single pass), respectively. The entire parenchymal component of the mixed hemorrhage was evacuated, as was the intraventricular component within the right frontal horn (single pass). No complications were experienced. All patients showed clinical improvement after the procedure. The average presenting National Institutes of Health Stroke Scale was 19.0, which had improved to 5.7 within an average of 4.7 days after the procedure. The Apollo system can be used within the neuroangiography suite for the minimally invasive evacuation of intracranial hemorrhage using simultaneous neuronavigation for planning and intraprocedural guidance, direct visualization with neuroendoscopy, and real time monitoring of progress with CB-CT. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

NOTE: Impedance magnetocardiogram

NASA Astrophysics Data System (ADS)

Kandori, Akihiko; Miyashita, Tsuyoshi; Suzuki, Daisuke; Yokosawa, Koichi; Tsukada, Keiji

2001-02-01

We have developed an impedance magnetocardiogram (IMCG) system to detect the change of magnetic field corresponding to changes in blood volume in the heart. A low magnetic field from the electrical activity of the human heart - the so-called magnetocardiogram (MCG) - can be simultaneously detected by using this system. Because the mechanical and electrical functions in the heart can be monitored by non-invasive and non-contact measurements, it is easy to observe the cardiovascular functions from an accurate sensor position. This system uses a technique to demodulate induced current in a subject. A flux-locked circuit of a superconducting quantum interference device has a wide frequency range (above 1 MHz) because a constant current (40 kHz) is fed through the subject. It is shown for the first time that the system could measure IMCG signals at the same time as MCG signals.

Influence of space weather on human organism at different geo-latitudes: telecommunication helio-medical monitoring "Geliomed" 2003-2010

NASA Astrophysics Data System (ADS)

Ragulskaya, Maria; Obridko, Vladimir; Samsonov, Sergey; Vitaliy, Vishnevskey; Grigoryev, Pavel; Valeriy, Pipin; Khabarova, Olga

We discuss the results of the long-term telecommunicative biogeophysical monitoring "Geliomed" (2003-2010). The purpose is to explore the effects of spatial and temporal variations in space weather and climatic factors on the human health state. The monitoring is carried out simultaneously at the different geographical areas that covers the different latitudes. The project developed in the joint collaboration the Ukrainian National Academy of Science and the Russian Academy of Science. The experiment carried out simultaneously in Moscow, Yakutsk, Kiev and Simferopol. The principal components of the experiment can be summarized as follows: 1. Equipments and data gathering methods are the same for all the scientific cen-ters which are involved in experiment. Research centers working with the same equipment and using the same protocols with on-line registration of current data on same portal server (http//geliomed.immsp.kiev.ua) 2. The groups of patients involved in the program are kept the same for the whole observational period of time. 3. The daily registered parameters in-clude: psycho-emotional tests and 1-st lead ECG (contain 25 000 measurements for the whole period), arterial pressure (100 000 measurements), variability cardiac contraction (25000 mea-surements), electric conduction of bioactive points on skin (more than 500 000 measurements for the whole period ). 4. The every patient in the monitoring group is examined at the 4 functional states. Registration is done at rest, after standard psychology test, Roufiet test, and after 10 min relax. 5. The data of the ECG measurements are analyzed in the phase space constructed from the signal and its derivative. 6. The results time series were compared with daily values of space weather and geomagnetic parameters. Results. In the all monitoring centers all the patients involved in the monitoring show the same type of changes in the cardiac activity parameters during an isolated magnetic storm. Such a change of the ECG parameters occurs nearly simultaneously for all the centers. The higher latitude, the greater amplitude of the ECG parameters change. The properties of the detected phenomena can be summarized as follows: -The dynamics of adaptation programs changes during the storm. The maximum amplitude of change is observed for the healthy patients. -The number of none-typical ECG beats increase; -There are no clear evidences for variations of RR intervals during geomagnetic storms. -Man are more sensitive to magnetic storms, while endogenous rhythms predominate for females; Additionally, we find, that the embedding of ECG time series in 3D phase space can be considered as a mix of a few states. At the rest, the occurrence of the basic ECG state compare to additional ones is about 8:2. The occurrence of the basic state increases after the stress. Thus, the external stress may change the relative disorder of the system. To understand the origin of the standard cardio-cycle changes we reconstruct of the dynamical model of the individual cardiac beat. The reconstruction reveals that the typical evolution of the cardiac rhythm includes the drift of attractor in the embedding space and the sudden change between a few basic patterns of attractor. However one of pattern is always dominating. These several pattern of ECG beat attractor can be ascribed to a several states of the system. Qualitatively, the nonlinear ECG dynamics is defined by the stationary points, which are inside into Q and T waves. Conclusions: many-year telecommunication heliomedical monitoring in different lat-itudes showed, that space and geophysical factor act as a training factor for the adaptation-resistant member of the population. It serve as a channel for rejection of nonviable members of the population, synchronize the total populations rhythms, create conditions for generation of new information in the process of evolution adaptation of biological systems in general.