The Common Core's Promises and Pitfalls from the Perspectives of Policy Entrepreneurs and Ground-Level Actors

ERIC Educational Resources Information Center

Kornhaber, Mindy L.; Barkauskas, Nikolaus J.; Griffith, Kelly M.; Sausner, Erica; Mahfouz, Julia

2017-01-01

The Common Core State Standards Initiative (Common Core) was spearheaded by policy entrepreneurs, unveiled nationally in 2010, and initially received strong support from leaders in state and federal government, philanthropic foundations, the business sector, and teacher unions. However, the reform came into the crosshairs of an ideologically wide…

The BRAIN Initiative Provides a Unifying Context for Integrating Core STEM Competencies into a Neurobiology Course.

PubMed

Schaefer, Jennifer E

2016-01-01

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative introduced by the Obama Administration in 2013 presents a context for integrating many STEM competencies into undergraduate neuroscience coursework. The BRAIN Initiative core principles overlap with core STEM competencies identified by the AAAS Vision and Change report and other entities. This neurobiology course utilizes the BRAIN Initiative to serve as the unifying theme that facilitates a primary emphasis on student competencies such as scientific process, scientific communication, and societal relevance while teaching foundational neurobiological content such as brain anatomy, cellular neurophysiology, and activity modulation. Student feedback indicates that the BRAIN Initiative is an engaging and instructional context for this course. Course module organization, suitable BRAIN Initiative commentary literature, sample primary literature, and important assignments are presented.

76 FR 79703 - Notice of Submission of Proposed Information Collection to OMB; Emergency Comment Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

... Building Under the Transformation Initiative (OneCPD and Core Curricula) AGENCY: Office of the Chief... Transformation Initiative (OneCPD and Core Curricula). Description of Information Collection: The Narratives...

Efficiency of Core Biopsy for BI-RADS-5 Breast Lesions.

PubMed

Wolf, Ronald; Quan, Glenda; Calhoun, Kris; Soot, Laurel; Skokan, Laurie

2008-01-01

Stereotactic biopsy has proven more cost effective for biopsy of lesions associated with moderately suspicious mammograms. Data regarding selection of stereotactic biopsy (CORE) instead of excisional biopsy (EB) as the first diagnostic procedure in patients with nonpalpable breast lesions and highest suspicion breast imaging-reporting and data system (BI-RADS)-5 mammograms are sparse. Records from a regional health system radiology database were screened for mammograms associated with image-guided biopsy. A total of 182 nonpalpable BI-RADS-5 lesions were sampled in 178 patients over 5 years, using CORE or EB. Initial surgical margins, number of surgeries, time from initial procedure to last related surgical procedure, and hospital and professional charges for related admissions were compared using chi-squared, t-test, and Wilcoxon Mann-Whitney tests. A total of 108 CORE and 74 EB were performed as the first diagnostic procedure. Invasive or in situ carcinoma was diagnosed in 156 (86%) of all biopsies, 95 in CORE and 61 in EB groups. Negative margins of the first surgical procedure were more frequent in CORE (n = 70, 74%) versus EB (n = 17, 28%), p < 0.05. Use of CORE was associated with fewer total surgical procedures per lesion (1.29 +/- 0.05 versus 1.8 +/- 0.05, p < 0.05). Time of initial diagnostic procedure to final treatment did not vary significantly according to group (27 +/- 2 days versus 22 +/- 2 days, CORE versus EB). Mean charges including the diagnostic procedure and all subsequent surgeries were not different between CORE and EB groups ($10,500 +/- 300 versus $11,500 +/- 500, p = 0.08). Use of CORE as the first procedure in patients with highly suspicious mammograms is associated with improved pathologic margins and need for fewer surgical procedures than EB, and should be considered the preferred initial diagnostic approach.

Core to College Evaluation: Exploring the Use of Multiple Measures for Placement into College-Level Courses. Seeking Alternatives or Improvements to the Use of a Single Standardized Test

ERIC Educational Resources Information Center

Bracco, Kathy Reeves; Dadgar, Mina; Austin, Kim; Klarin, Becca; Broek, Marie; Finkelstein, Neal; Mundry, Susan; Bugler, Dan

2014-01-01

"Core to College: Preparing Students for College Readiness and Success" is a three-year initiative. The initiative's mission is to "facilitate greater coordination between K-12 and postsecondary education systems around implementation of the Common Core State Standards (CCSS) and aligned assessments." Its aim is to foster…

Prediction of core level binding energies in density functional theory: Rigorous definition of initial and final state contributions and implications on the physical meaning of Kohn-Sham energies.

PubMed

Pueyo Bellafont, Noèlia; Bagus, Paul S; Illas, Francesc

2015-06-07

A systematic study of the N(1s) core level binding energies (BE's) in a broad series of molecules is presented employing Hartree-Fock (HF) and the B3LYP, PBE0, and LC-BPBE density functional theory (DFT) based methods with a near HF basis set. The results show that all these methods give reasonably accurate BE's with B3LYP being slightly better than HF but with both PBE0 and LCBPBE being poorer than HF. A rigorous and general decomposition of core level binding energy values into initial and final state contributions to the BE's is proposed that can be used within either HF or DFT methods. The results show that Koopmans' theorem does not hold for the Kohn-Sham eigenvalues. Consequently, Kohn-Sham orbital energies of core orbitals do not provide estimates of the initial state contribution to core level BE's; hence, they cannot be used to decompose initial and final state contributions to BE's. However, when the initial state contribution to DFT BE's is properly defined, the decompositions of initial and final state contributions given by DFT, with several different functionals, are very similar to those obtained with HF. Furthermore, it is shown that the differences of Kohn-Sham orbital energies taken with respect to a common reference do follow the trend of the properly calculated initial state contributions. These conclusions are especially important for condensed phase systems where our results validate the use of band structure calculations to determine initial state contributions to BE shifts.

Effect of core cooling on the radius of sub-Neptune planets

NASA Astrophysics Data System (ADS)

Vazan, A.; Ormel, C. W.; Dominik, C.

2018-02-01

Sub-Neptune planets are very common in our Galaxy and show a large diversity in their mass-radius relation. In sub-Neptunes most of the planet mass is in the rocky part (hereafter, core), which is surrounded by a modest hydrogen-helium envelope. As a result, the total initial heat content of such a planet is dominated by that of the core. Nonetheless, most studies contend that the core cooling only has a minor effect on the radius evolution of the gaseous envelope because the cooling of the core is in sync with the envelope; that is most of the initial heat is released early on timescales of 10-100 Myr. In this Letter we examined the importance of the core cooling rate for the thermal evolution of the envelope. Thus, we relaxed the early core cooling assumption and present a model in which the core is characterized by two parameters: the initial temperature and the cooling time. We find that core cooling can significantly enhance the radius of the planet when it operates on a timescale similar to the observed age, i.e. Gyr. Consequently, the interpretation of the mass-radius observations of sub-Neptunes depends on the assumed core thermal properties and the uncertainty therein. The degeneracy of composition and core thermal properties can be reduced by obtaining better estimates of the planet ages (in addition to their radii and masses) as envisioned by future observations.

The Integration of Common Core and Response to Intervention: Supporting Vulnerable Readers in a Time of Sophisticated Standards

ERIC Educational Resources Information Center

Jaeger, Elizabeth L.; Pearson, P. David

2017-01-01

The Common Core State Standards and Response to Intervention are significant contemporary educational initiatives that have emerged largely in isolation from one another. We argue that an integration of these initiatives is beneficial. We trace the independent development of these two initiatives and offer suggestions for how they might fruitfully…

Weather Research and Forecasting Model Sensitivity Comparisons for Warm Season Convective Initiation

NASA Technical Reports Server (NTRS)

Watson, Leela R.

2007-01-01

This report describes the work done by the Applied Meteorology Unit (AMU) in assessing the success of different model configurations in predicting warm season convection over East-Central Florida. The Weather Research and Forecasting Environmental Modeling System (WRF EMS) software allows users to choose among two dynamical cores - the Advanced Research WRF (ARW) and the Non-hydrostatic Mesoscale Model (NMM). There are also data assimilation analysis packages available for the initialization of the WRF model - the Local Analysis and Prediction System (LAPS) and the Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS). Besides model core and initialization options, the WRF model can be run with one- or two-way nesting. Having a series of initialization options and WRF cores, as well as many options within each core, creates challenges for local forecasters, such as determining which configuration options are best to address specific forecast concerns. This project assessed three different model intializations available to determine which configuration best predicts warm season convective initiation in East-Central Florida. The project also examined the use of one- and two-way nesting in predicting warm season convection.

The Movement for National Academic Standards: A Comparison of the Common Core State Standards Initiative in the USA and the National Curriculum in Australia

ERIC Educational Resources Information Center

Watt, Michael

2009-01-01

The purpose of this study is to evaluate the nature of activities in the change process undertaken by two initiatives to produce national standards in academic disciplines, national assessments and accountability measures. The Common Core State Standards Initiative, a project coordinated by the National Governors Association and the Council of…

Minor Actinides-Loaded FBR Core Concept Suitable for the Introductory Period in Japan

NASA Astrophysics Data System (ADS)

Fujimura, Koji; Sasahira, Akira; Yamashita, Junichi; Fukasawa, Tetsuo; Hoshino, Kuniyoshi

According to the Japan's Framework for Nuclear Energy Policy(1), a basic scenario for fast breeder reactors (FBRs) is that they will be introduced on a commercial basis starting around 2050 replacing light water reactors (LWRs). During the FBR introduction period, the Pu from LWR spent fuel is used for FBR startup. Howerver, the FBR core loaded with this Pu has a larger burnup reactivity due to its larger isotopic content of Pu-241 than a core loaded with Pu from an FBR multi-recycling core. The increased burnup reactivity may reduce the cycle length of an FBR. We investigated, an FBR transitional core concept to confront the issues of the FBR introductory period in Japan. Core specifications are based on the compact-type sodium-cooled mixed oxide (MOX)-fueled core designed from the Japanese FBR cycle feasibility studies, because lower Pu inventory should be better for the FBR introductory period in view of its flexibility for the required reprocessing amount of LWR spent fuel to start up FBRs. The reference specifications were selected as follows. Output of 1500MWe and average discharge fuel burnup of about 150GWd/t. Minor Actinides (MAs) recovered from LWR spent fuels which provide Pu to startup FBRs are loaded to the initial loading fuels and exchanged fuels during few cycles until equilibrium. We made the MA content of the initial loading fuel four kinds like 0%, 3%, 4%, 5%. The average of the initial loading fuel is assumed to be 3%, and that of the exchange fuel is set as 5%. This 5% maximum of the MA content is based on the irradiation results of the experimental fast reactor Joyo. We evaluated the core performances including burnup characteristics and the reactivity coefficient and confirmed that transitional core from initial loading until equilibrium cycle with loaded Pu from LWR spent fuel performs similary to an FBR multi-recycling core.

Overview of the Common Core State Standard initiative and educational reform movement from the vantage of speech-language pathologists.

PubMed

Staskowski, Maureen

2012-05-01

Educational reform is sweeping the country. The adoption and the implementation of the Common Core State Standards in almost every state are meant to transform education. It is intended to update the way schools educate, the way students learn, and to ultimately prepare the nation's next generation for the global workplace. This article will describe the Common Core State Standard initiative and the underlying concerns about the quality of education in the United States as well as the opportunities this reform initiative affords speech-language pathologists. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The French initiative for scientific cores virtual curating : a user-oriented integrated approach

NASA Astrophysics Data System (ADS)

Pignol, Cécile; Godinho, Elodie; Galabertier, Bruno; Caillo, Arnaud; Bernardet, Karim; Augustin, Laurent; Crouzet, Christian; Billy, Isabelle; Teste, Gregory; Moreno, Eva; Tosello, Vanessa; Crosta, Xavier; Chappellaz, Jérome; Calzas, Michel; Rousseau, Denis-Didier; Arnaud, Fabien

2016-04-01

Managing scientific data is probably one the most challenging issue in modern science. The question is made even more sensitive with the need of preserving and managing high value fragile geological sam-ples: cores. Large international scientific programs, such as IODP or ICDP are leading an intense effort to solve this problem and propose detailed high standard work- and dataflows thorough core handling and curating. However most results derived from rather small-scale research programs in which data and sample management is generally managed only locally - when it is … The national excellence equipment program (Equipex) CLIMCOR aims at developing French facilities for coring and drilling investigations. It concerns indiscriminately ice, marine and continental samples. As part of this initiative, we initiated a reflexion about core curating and associated coring-data management. The aim of the project is to conserve all metadata from fieldwork in an integrated cyber-environment which will evolve toward laboratory-acquired data storage in a near future. In that aim, our demarche was conducted through an close relationship with field operators as well laboratory core curators in order to propose user-oriented solutions. The national core curating initiative currently proposes a single web portal in which all scientifics teams can store their field data. For legacy samples, this will requires the establishment of a dedicated core lists with associated metadata. For forthcoming samples, we propose a mobile application, under Android environment to capture technical and scientific metadata on the field. This application is linked with a unique coring tools library and is adapted to most coring devices (gravity, drilling, percussion, etc...) including multiple sections and holes coring operations. Those field data can be uploaded automatically to the national portal, but also referenced through international standards or persistent identifiers (IGSN, ORCID and INSPIRE) and displayed in international portals (currently, NOAA's IMLGS). In this paper, we present the architecture of the integrated system, future perspectives and the approach we adopted to reach our goals. We will also present in front of our poster, one of the three mobile applications, dedicated more particularly to the operations of continental drillings.

Neodymium-YAG laser core through urethrotomy in obliterative posttraumatic urethral strictures after failed initial urethroplasty.

PubMed

Dogra, P N; Nabi, G

2002-01-01

To assess the feasibility, problems and results of Nd-YAG laser core through urethrotomy in the management of failed urethroplasty for posttraumatic bulbomembranous urethral strictures. 61 patients with obliterative posttraumatic urethral strictures were treated by Nd-YAG laser core through urethrotomy between May 1997 to April 2000. Of these, 5 patients had failed end-to-end urethroplasty done as an initial procedure at various periods of time. The procedure was performed as day care and patients were discharged within 6 h of procedure. At 24-30 months of follow-up, all patients are voiding well and are continent. Auxiliary procedures were required in 2 cases. Nd-YAG laser core through urethrotomy is a feasible day care option for patients of obliterative urethral strictures following failed initial urethroplasty with successful outcome. Copyright 2002 S. Karger AG, Basel

Supernova 2007bi as a pair-instability explosion.

PubMed

Gal-Yam, A; Mazzali, P; Ofek, E O; Nugent, P E; Kulkarni, S R; Kasliwal, M M; Quimby, R M; Filippenko, A V; Cenko, S B; Chornock, R; Waldman, R; Kasen, D; Sullivan, M; Beshore, E C; Drake, A J; Thomas, R C; Bloom, J S; Poznanski, D; Miller, A A; Foley, R J; Silverman, J M; Arcavi, I; Ellis, R S; Deng, J

2009-12-03

Stars with initial masses such that 10M[symbol: see text] or= 140M[symbol: see text] (if such exist) develop oxygen cores with masses, M(core), that exceed 50M[symbol: see text], where high temperatures are reached at relatively low densities. Conversion of energetic, pressure-supporting photons into electron-positron pairs occurs before oxygen ignition and leads to a violent contraction which triggers a nuclear explosion that unbinds the star in a pair-instability supernova. Transitional objects with 100M[symbol: see text] < M(initial) < 140M[symbol: see text] may end up as iron-core-collapse supernovae following violent mass ejections, perhaps as a result of brief episodes of pair instability, and may already have been identified. Here we report observations of supernova SN 2007bi, a luminous, slowly evolving object located within a dwarf galaxy. We estimate the exploding core mass to be M(core) approximately 100M[symbol: see text], in which case theory unambiguously predicts a pair-instability supernova. We show that >3M[symbol: see text] of radioactive (56)Ni was synthesized during the explosion and that our observations are well fitted by models of pair-instability supernovae. This indicates that nearby dwarf galaxies probably host extremely massive stars, above the apparent Galactic stellar mass limit, which perhaps result from processes similar to those that created the first stars in the Universe.

Armor systems including coated core materials

DOEpatents

Chu, Henry S [Idaho Falls, ID; Lillo, Thomas M [Idaho Falls, ID; McHugh, Kevin M [Idaho Falls, ID

2012-07-31

An armor system and method involves providing a core material and a stream of atomized coating material that comprises a liquid fraction and a solid fraction. An initial layer is deposited on the core material by positioning the core material in the stream of atomized coating material wherein the solid fraction of the stream of atomized coating material is less than the liquid fraction of the stream of atomized coating material on a weight basis. An outer layer is then deposited on the initial layer by positioning the core material in the stream of atomized coating material wherein the solid fraction of the stream of atomized coating material is greater than the liquid fraction of the stream of atomized coating material on a weight basis.

Armor systems including coated core materials

DOEpatents

Chu, Henry S; Lillo, Thomas M; McHugh, Kevin M

2013-10-08

An armor system and method involves providing a core material and a stream of atomized coating material that comprises a liquid fraction and a solid fraction. An initial layer is deposited on the core material by positioning the core material in the stream of atomized coating material wherein the solid fraction of the stream of atomized coating material is less than the liquid fraction of the stream of atomized coating material on a weight basis. An outer layer is then deposited on the initial layer by positioning the core material in the stream of atomized coating material wherein the solid fraction of the stream of atomized coating material is greater than the liquid fraction of the stream of atomized coating material on a weight basis.

International Metadata Initiatives: Lessons in Bibliographic Control.

ERIC Educational Resources Information Center

Caplan, Priscilla

This paper looks at a subset of metadata schemes, including the Text Encoding Initiative (TEI) header, the Encoded Archival Description (EAD), the Dublin Core Metadata Element Set (DCMES), and the Visual Resources Association (VRA) Core Categories for visual resources. It examines why they developed as they did, major point of difference from…

The influence of the depth of k-core layers on the robustness of interdependent networks against cascading failures

NASA Astrophysics Data System (ADS)

Dong, Zhengcheng; Fang, Yanjun; Tian, Meng; Kong, Zhengmin

The hierarchical structure, k-core, is common in various complex networks, and the actual network always has successive layers from 1-core layer (the peripheral layer) to km-core layer (the core layer). The nodes within the core layer have been proved to be the most influential spreaders, but there is few work about how the depth of k-core layers (the value of km) can affect the robustness against cascading failures, rather than the interdependent networks. First, following the preferential attachment, a novel method is proposed to generate the scale-free network with successive k-core layers (KCBA network), and the KCBA network is validated more realistic than the traditional BA network. Then, with KCBA interdependent networks, the effect of the depth of k-core layers is investigated. Considering the load-based model, the loss of capacity on nodes is adopted to quantify the robustness instead of the number of functional nodes in the end. We conduct two attacking strategies, i.e. the RO-attack (Randomly remove only one node) and the RF-attack (Randomly remove a fraction of nodes). Results show that the robustness of KCBA networks not only depends on the depth of k-core layers, but also is slightly influenced by the initial load. With RO-attack, the networks with less k-core layers are more robust when the initial load is small. With RF-attack, the robustness improves with small km, but the improvement is getting weaker with the increment of the initial load. In a word, the lower the depth is, the more robust the networks will be.

Differentiated planetesimal impacts into a terrestrial magma ocean: Fate of the iron core

NASA Astrophysics Data System (ADS)

Kendall, Jordan D.; Melosh, H. J.

2016-08-01

The abundance of moderately siderophile elements (;iron-loving;; e.g. Co, Ni) in the Earth's mantle is 10 to 100 times larger than predicted by chemical equilibrium between silicate melt and iron at low pressure, but it does match expectation for equilibrium at high pressure and temperature. Recent studies of differentiated planetesimal impacts assume that planetesimal cores survive the impact intact as concentrated masses that passively settle from a zero initial velocity and undergo turbulent entrainment in a global magma ocean; under these conditions, cores greater than 10 km in diameter do not fully mix without a sufficiently deep magma ocean. We have performed hydrocode simulations that revise this assumption and yield a clearer picture of the impact process for differentiated planetesimals possessing iron cores with radius = 100 km that impact into magma oceans. The impact process strips away the silicate mantle of the planetesimal and then stretches the iron core, dispersing the liquid iron into a much larger volume of the underlying liquid silicate mantle. Lagrangian tracer particles track the initially intact iron core as the impact stretches and disperses the core. The final displacement distance of initially closest tracer pairs gives a metric of core stretching. The statistics of stretching imply mixing that separates the iron core into sheets, ligaments, and smaller fragments, on a scale of 10 km or less. The impact dispersed core fragments undergo further mixing through turbulent entrainment as the molten iron fragments rain through the magma ocean and settle deeper into the planet. Our results thus support the idea that iron in the cores of even large differentiated planetesimals can chemically equilibrate deep in a terrestrial magma ocean.

Navigating Ethics in the Digital Age: Introducing Connected and Open Research Ethics (CORE), a Tool for Researchers and Institutional Review Boards

PubMed Central

Torous, John

2017-01-01

Research studies that leverage emerging technologies, such as passive sensing devices and mobile apps, have demonstrated encouraging potential with respect to favorably influencing the human condition. As a result, the nascent fields of mHealth and digital medicine have gained traction over the past decade as demonstrated in the United States by increased federal funding for research that cuts across a broad spectrum of health conditions. The existence of mHealth and digital medicine also introduced new ethical and regulatory challenges that both institutional review boards (IRBs) and researchers are struggling to navigate. In response, the Connected and Open Research Ethics (CORE) initiative was launched. The CORE initiative has employed a participatory research approach, whereby researchers and IRB affiliates are involved in identifying the priorities and functionality of a shared resource. The overarching goal of CORE is to develop dynamic and relevant ethical practices to guide mHealth and digital medicine research. In this Viewpoint paper, we describe the CORE initiative and call for readers to join the CORE Network and contribute to the bigger conversation on ethics in the digital age. PMID:28179216

Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting.

PubMed

Schmitt, Jochen; Spuls, Phyllis; Boers, Maarten; Thomas, Kim; Chalmers, Joanne; Roekevisch, Evelien; Schram, Mandy; Allsopp, Richard; Aoki, Valeria; Apfelbacher, Christian; Bruijnzeel-Koomen, Carla; Bruin-Weller, Marjolein; Charman, Carolyn; Cohen, Arnon; Dohil, Magdalene; Flohr, Carsten; Furue, Masutaka; Gieler, Uwe; Hooft, Lotty; Humphreys, Rosemary; Ishii, Henrique Akira; Katayama, Ichiro; Kouwenhoven, Willem; Langan, Sinéad; Lewis-Jones, Sue; Merhand, Stephanie; Murota, Hiroyuki; Murrell, Dedee F; Nankervis, Helen; Ohya, Yukihiro; Oranje, Arnold; Otsuka, Hiromi; Paul, Carle; Rosenbluth, Yael; Saeki, Hidehisa; Schuttelaar, Marie-Louise; Stalder, Jean-Francois; Svensson, Ake; Takaoka, Roberto; Wahlgren, Carl-Fredrik; Weidinger, Stephan; Wollenberg, Andreas; Williams, Hywel

2012-09-01

The use of nonstandardized and inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising evidence-based dermatology. The Harmonising Outcome Measures for Eczema (HOME) initiative is an international multiprofessional group dedicated to atopic eczema outcomes research. In June 2011, the HOME initiative conducted a consensus study involving 43 individuals from 10 countries, representing different stakeholders (patients, clinicians, methodologists, pharmaceutical industry) to determine core outcome domains for atopic eczema trials, to define quality criteria for atopic eczema outcome measures and to prioritize topics for atopic eczema outcomes research. Delegates were given evidence-based information, followed by structured group discussion and anonymous consensus voting. Consensus was achieved to include clinical signs, symptoms, long-term control of flares and quality of life into the core set of outcome domains for atopic eczema trials. The HOME initiative strongly recommends including and reporting these core outcome domains as primary or secondary endpoints in all future atopic eczema trials. Measures of these core outcome domains need to be valid, sensitive to change and feasible. Prioritized topics of the HOME initiative are the identification/development of the most appropriate instruments for the four core outcome domains. HOME is open to anyone with an interest in atopic eczema outcomes research. © 2012 John Wiley & Sons A/S.

The Common Core Standards: A Teacher Board Member's Perspective

ERIC Educational Resources Information Center

Bumgarner, Kami Burns

2012-01-01

As the teacher representative on the Mississippi Board of Education, the author often has the opportunity to hear about many educational programs and initiatives during their early stages of development. One particular initiative presented to the state board in 2010 was the Common Core State Standards. After reading and studying the standards, the…

The Alzheimer’s Disease Neuroimaging Initiative Informatics Core: A Decade in Review

PubMed Central

Toga, Arthur W.; Crawford, Karen L.

2015-01-01

The Informatics Core of the Alzheimer’s Diseases Neuroimaging Initiative (ADNI) has coordinated data integration and dissemination for a continually growing and complex dataset in which both data contributors and recipients span institutions, scientific disciplines and geographic boundaries. This article provides an update on the accomplishments and future plans. PMID:26194316

Common Core State Standards: I Wonder?

ERIC Educational Resources Information Center

Tienken, Christopher H.

2010-01-01

On June 1, 2009, the National Governors Association Center for Best Practices (NGA Center) and the Council of Chief State School Officers (CCSSO) issued a press release stating that 49 states and territories had joined the Common Core State Standards Initiative (CCSS). That initiative proposed that all states voluntarily adopt the same set of…

Update on the Common Core State Standards Initiative

ERIC Educational Resources Information Center

Ritter, Bill, Jr.

2009-01-01

In this update the National Governors Association presents the testimony of Honorable Bill Ritter, Jr., as submitted to the U.S. House Education and Labor Committee. Ritter speaks about the Common Core State Standards Initiative, a joint project by the National Governors Association (NGA) and Council of Chief State School Officers (CCSSO) to…

Penetrator Coring Apparatus for Cometary Surfaces

NASA Technical Reports Server (NTRS)

Braun, David F.; Heinrich, Michael; Ai, Huirong Anita; Ahrens, Thomas J.

2004-01-01

Touch and go impact coring is an attractive technique for sampling cometary nuclei and asteroidal surface on account of the uncertain strength properties and low surface gravities of these objects. Initial coring experiments in low temperature (approx. 153K polycrystalline ice) and porous rock demonstrate that simultaneous with impact coring, measurements of both the penetration strength and constraints on the frictional properties of surface materials can be obtained upon core penetration and core sample extraction. The method of sampling an asteroid, to be deployed, on the now launched MUSES-C mission, employs a small gun device that fires into the asteroid and the resulted impact ejecta is collected for return to Earth. This technique is well suited for initial sampling in a very low gravity environment and deployment depends little on asteroid surface mechanical properties. Since both asteroids and comets are believed to have altered surface properties a simple sampling apparatus that preserves stratigraphic information, such as impact coring is an attractive alternate to impact ejecta collection.

Shape Sensing Using a Multi-Core Optical Fiber Having an Arbitrary Initial Shape in the Presence of Extrinsic Forces

NASA Technical Reports Server (NTRS)

Rogge, Matthew D. (Inventor); Moore, Jason P. (Inventor)

2014-01-01

Shape of a multi-core optical fiber is determined by positioning the fiber in an arbitrary initial shape and measuring strain over the fiber's length using strain sensors. A three-coordinate p-vector is defined for each core as a function of the distance of the corresponding cores from a center point of the fiber and a bending angle of the cores. The method includes calculating, via a controller, an applied strain value of the fiber using the p-vector and the measured strain for each core, and calculating strain due to bending as a function of the measured and the applied strain values. Additionally, an apparent local curvature vector is defined for each core as a function of the calculated strain due to bending. Curvature and bend direction are calculated using the apparent local curvature vector, and fiber shape is determined via the controller using the calculated curvature and bend direction.

Under Construction: Benchmark Assessments and Common Core Math Implementation in Grades K-8. Formative Evaluation Cycle Report for the Math in Common Initiative, Volume 1

ERIC Educational Resources Information Center

Flaherty, John, Jr.; Sobolew-Shubin, Alexandria; Heredia, Alberto; Chen-Gaddini, Min; Klarin, Becca; Finkelstein, Neal D.

2014-01-01

Math in Common® (MiC) is a five-year initiative that supports a formal network of 10 California school districts as they implement the Common Core State Standards in mathematics (CCSS-M) across grades K-8. As the MiC initiative moves into its second year, one of the central activities that each of the districts is undergoing to support CCSS…

Core to College Evaluation: Statewide Networks. Connecting Education Systems and Stakeholders to Support College Readiness

ERIC Educational Resources Information Center

Bracco, Kathy Reeves; Klarin, Becca; Broek, Marie; Austin, Kim; Finkelstein, Neal; Bugler, Daniel; Mundry, Susan

2014-01-01

The Core to College initiative aims to facilitate greater coordination between K-12 and postsecondary education systems around implementation of the Common Core State Standards and aligned assessments. Core to College grants have been awarded to teams in Colorado, Florida, Hawaii, Kentucky, Louisiana, Massachusetts, North Carolina, Oregon,…

Pore-water extraction from unsaturated tuff by triaxial and one-dimensional compression methods, Nevada Test Site, Nevada

USGS Publications Warehouse

Mower, Timothy E.; Higgins, Jerry D.; Yang, In C.; Peters, Charles A.

1994-01-01

Study of the hydrologic system at Yucca Mountain, Nevada, requires the extraction of pore-water samples from welded and nonwelded, unsaturated tuffs. Two compression methods (triaxial compression and one-dimensional compression) were examined to develop a repeatable extraction technique and to investigate the effects of the extraction method on the original pore-fluid composition. A commercially available triaxial cell was modified to collect pore water expelled from tuff cores. The triaxial cell applied a maximum axial stress of 193 MPa and a maximum confining stress of 68 MPa. Results obtained from triaxial compression testing indicated that pore-water samples could be obtained from nonwelded tuff cores that had initial moisture contents as small as 13 percent (by weight of dry soil). Injection of nitrogen gas while the test core was held at the maximum axial stress caused expulsion of additional pore water and reduced the required initial moisture content from 13 to 11 percent. Experimental calculations, together with experience gained from testing moderately welded tuff cores, indicated that the triaxial cell used in this study could not apply adequate axial or confining stress to expel pore water from cores of densely welded tuffs. This concern led to the design, fabrication, and testing of a one-dimensional compression cell. The one-dimensional compression cell used in this study was constructed from hardened 4340-alloy and nickel-alloy steels and could apply a maximum axial stress of 552 MPa. The major components of the device include a corpus ring and sample sleeve to confine the sample, a piston and base platen to apply axial load, and drainage plates to transmit expelled water from the test core out of the cell. One-dimensional compression extracted pore water from nonwelded tuff cores that had initial moisture contents as small as 7.6 percent; pore water was expelled from densely welded tuff cores that had initial moisture contents as small as 7.7 percent. Injection of nitrogen gas at the maximum axial stress did not produce additional pore water from nonwelded tuff cores, but was critical to recovery of pore water from densely welded tuff cores. Gas injection reduced the required initial moisture content in welded tuff cores from 7.7 to 6.5 percent. Based on the mechanical ability of a pore-water extraction method to remove water from welded and nonwelded tuff cores, one-dimensional compression is a more effective extraction method than triaxial compression. However, because the effects that one-dimensional compression has on pore-water chemistry are not completely understood, additional testing will be needed to verify that this method is suitable for pore-water extraction from Yucca Mountain tuffs.

Math in Common. Taking Stock of Common Core Math Implementation: Supporting Teachers to Shift Instruction. Insights from the Math in Common 2015 Baseline Survey of Teachers and Administrators. Formative Evaluation Cycle Report for the Math in Common Initiative: Volume 3

ERIC Educational Resources Information Center

Perry, Rebecca R.; Finkelstein, Neal D.; Seago, Nanette; Heredia, Alberto; Sobolew-Shubin, Sandy; Carroll, Cathy

2015-01-01

Math in Common® (MiC) is a five-year initiative that supports a formal network of 10 California school districts as they implement the Common Core State Standards in Mathematics (CCSS-M) across grades K-8. In spring 2015, WestEd administered surveys to understand the perspectives on Common Core State Standards-Mathematics (CCSS-M) implementation…

The CROWN Initiative: journal editors invite researchers to develop core outcomes in women's health.

PubMed

Leese, Henry

2014-09-01

Human Fertility is pleased to support the 'CROWN' initiative outlined below, whose aim is 'to develop core outcomes in women's health'. The editorial, which was unanimously adopted by our Editorial Board is being published by more than 50 gynaecology-obstetrics and related journals. We commend it to all our readers.

Networked Governance in Three Policy Areas with Implications for the Common Core State Standards Initiative

ERIC Educational Resources Information Center

Manna, Paul

2010-01-01

Policy makers and researchers now recognize that designing effective institutions to govern policy networks is a major challenge of the 21st Century. Presently, the Common Core State Standards Initiative resembles an emerging network of organizations united around the goal of developing clear and challenging academic expectations for students in…

New Bottles for Old Wine? California State University Initiates an Electronic Core Journals Collection.

ERIC Educational Resources Information Center

Healy, Leigh Watson

1999-01-01

The Journal Access Core Collection (JACC) initiative of the California State University (CSU) enables libraries to address the demand for print journals collections in a cooperative acquisitions project by offering their most heavily used journals to all CSU users on the Web. Implementation of the JACC, its key requirements and future…

Teaching under the Policy Cascades: Common Core, Learned Dependency, and Literacy Instruction

ERIC Educational Resources Information Center

Papola, Aimee L.

2012-01-01

Educational policies and initiatives continually influence the instruction in classrooms across the nation. At the time of this study, the Common Core State Standards Initiative was in its first full year of implementation in schools across the country. Using ethnographic methods (Foley, 1990; Heath, 1983; McLaren, 1986) and a critical theory…

How Will the Common Core Initiative Impact the Testing Industry?

ERIC Educational Resources Information Center

Toch, Thomas; Tyre, Peg

2010-01-01

The National Governors Association and the Council of Chief State School Officers have sponsored the development of common K-12 education standards in math and English/language arts--a project known as the Common Core State Standards Initiative (CCSSI)--in an effort to improve college readiness for the nation's students and replace the patchwork…

A Case Study of Common Core Implementation in a Linked Learning Environment

ERIC Educational Resources Information Center

Biolchino, Erin Broun

2016-01-01

California is in the midst of significant educational reform initiatives, especially at the secondary level. The Common Core State Standards (CCSS) were adopted in 2010, and these new standards contain significant changes in the areas of math, English, and literacy across all subjects. Many districts are also implementing new initiatives to engage…

Navigating Ethics in the Digital Age: Introducing Connected and Open Research Ethics (CORE), a Tool for Researchers and Institutional Review Boards.

PubMed

Torous, John; Nebeker, Camille

2017-02-08

Research studies that leverage emerging technologies, such as passive sensing devices and mobile apps, have demonstrated encouraging potential with respect to favorably influencing the human condition. As a result, the nascent fields of mHealth and digital medicine have gained traction over the past decade as demonstrated in the United States by increased federal funding for research that cuts across a broad spectrum of health conditions. The existence of mHealth and digital medicine also introduced new ethical and regulatory challenges that both institutional review boards (IRBs) and researchers are struggling to navigate. In response, the Connected and Open Research Ethics (CORE) initiative was launched. The CORE initiative has employed a participatory research approach, whereby researchers and IRB affiliates are involved in identifying the priorities and functionality of a shared resource. The overarching goal of CORE is to develop dynamic and relevant ethical practices to guide mHealth and digital medicine research. In this Viewpoint paper, we describe the CORE initiative and call for readers to join the CORE Network and contribute to the bigger conversation on ethics in the digital age. ©John Torous, Camille Nebeker. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 08.02.2017.

Upgrade of Irradiation Test Capability of the Experimental Fast Reactor Joyo

NASA Astrophysics Data System (ADS)

Sekine, Takashi; Aoyama, Takafumi; Suzuki, Soju; Yamashita, Yoshioki

2003-06-01

The JOYO MK-II core was operated from 1983 to 2000 as fast neutron irradiation bed. In order to meet various requirements for irradiation tests for development of FBRs, the JOYO upgrading project named MK-III program was initiated. The irradiation capability in the MK-III core will be about four times larger than that of the MK-II core. Advanced irradiation test subassemblies such as capsule type subassembly and on-line instrumentation rig are planned. As an innovative reactor safety system, the irradiation test of Self-Actuated Shutdown System (SASS) will be conducted. In order to improve the accuracy of neutron fluence, the core management code system was upgraded, and the Monte Carlo code and Helium Accumulation Fluence Monitor (HAFM) were applied. The MK-III core is planned to achieve initial criticality in July 2003.

17 CFR Appendix B to Part 38 - Guidance on, and Acceptable Practices in, Compliance With Core Principles

Code of Federal Regulations, 2010 CFR

2010-04-01

... Practices in, Compliance With Core Principles B Appendix B to Part 38 Commodity and Securities Exchanges...—Guidance on, and Acceptable Practices in, Compliance With Core Principles 1. This appendix provides guidance on complying with the core principles, both initially and on an ongoing basis, to maintain...

Three-dimensional discrete element method simulation of core disking

NASA Astrophysics Data System (ADS)

Wu, Shunchuan; Wu, Haoyan; Kemeny, John

2018-04-01

The phenomenon of core disking is commonly seen in deep drilling of highly stressed regions in the Earth's crust. Given its close relationship with the in situ stress state, the presence and features of core disking can be used to interpret the stresses when traditional in situ stress measuring techniques are not available. The core disking process was simulated in this paper using the three-dimensional discrete element method software PFC3D (particle flow code). In particular, PFC3D is used to examine the evolution of fracture initiation, propagation and coalescence associated with core disking under various stress states. In this paper, four unresolved problems concerning core disking are investigated with a series of numerical simulations. These simulations also provide some verification of existing results by other researchers: (1) Core disking occurs when the maximum principal stress is about 6.5 times the tensile strength. (2) For most stress situations, core disking occurs from the outer surface, except for the thrust faulting stress regime, where the fractures were found to initiate from the inner part. (3) The anisotropy of the two horizontal principal stresses has an effect on the core disking morphology. (4) The thickness of core disk has a positive relationship with radial stress and a negative relationship with axial stresses.

Deuterium fractionation and H2D+ evolution in turbulent and magnetized cloud cores

NASA Astrophysics Data System (ADS)

Körtgen, Bastian; Bovino, Stefano; Schleicher, Dominik R. G.; Giannetti, Andrea; Banerjee, Robi

2017-08-01

High-mass stars are expected to form from dense prestellar cores. Their precise formation conditions are widely discussed, including their virial condition, which results in slow collapse for supervirial cores with strong support by turbulence or magnetic fields, or fast collapse for subvirial sources. To disentangle their formation processes, measurements of the deuterium fractions are frequently employed to approximately estimate the ages of these cores and to obtain constraints on their dynamical evolution. We here present 3D magnetohydrodynamical simulations including for the first time an accurate non-equilibrium chemical network with 21 gas-phase species plus dust grains and 213 reactions. With this network we model the deuteration process in fully depleted prestellar cores in great detail and determine its response to variations in the initial conditions. We explore the dependence on the initial gas column density, the turbulent Mach number, the mass-to-magnetic flux ratio and the distribution of the magnetic field, as well as the initial ortho-to-para ratio (OPR) of H2. We find qualitatively good agreement with recent observations of deuterium fractions in quiescent sources. Our results show that deuteration is rather efficient, even when assuming a conservative OPR of 3 and highly subvirial initial conditions, leading to large deuterium fractions already within roughly a free-fall time. We discuss the implications of our results and give an outlook to relevant future investigations.

Hepatitis C Virus core+1/ARF Protein Modulates the Cyclin D1/pRb Pathway and Promotes Carcinogenesis.

PubMed

Moustafa, Savvina; Karakasiliotis, Ioannis; Mavromara, Penelope

2018-05-01

Viruses often encompass overlapping reading frames and unconventional translation mechanisms in order to maximize the output from a minimum genome and to orchestrate their timely gene expression. Hepatitis C virus (HCV) possesses such an unconventional open reading frame (ORF) within the core-coding region, encoding an additional protein, initially designated ARFP, F, or core+1. Two predominant isoforms of core+1/ARFP have been reported, core+1/L, initiating from codon 26, and core+1/S, initiating from codons 85/87 of the polyprotein coding region. The biological significance of core+1/ARFP expression remains elusive. The aim of the present study was to gain insight into the functional and pathological properties of core+1/ARFP through its interaction with the host cell, combining in vitro and in vivo approaches. Our data provide strong evidence that the core+1/ARFP of HCV-1a stimulates cell proliferation in Huh7-based cell lines expressing either core+1/S or core+1/L isoforms and in transgenic liver disease mouse models expressing core+1/S protein in a liver-specific manner. Both isoforms of core+1/ARFP increase the levels of cyclin D1 and phosphorylated Rb, thus promoting the cell cycle. In addition, core+1/S was found to enhance liver regeneration and oncogenesis in transgenic mice. The induction of the cell cycle together with increased mRNA levels of cell proliferation-related oncogenes in cells expressing the core+1/ARFP proteins argue for an oncogenic potential of these proteins and an important role in HCV-associated pathogenesis. IMPORTANCE This study sheds light on the biological importance of a unique HCV protein. We show here that core+1/ARFP of HCV-1a interacts with the host machinery, leading to acceleration of the cell cycle and enhancement of liver carcinogenesis. This pathological mechanism(s) may complement the action of other viral proteins with oncogenic properties, leading to the development of hepatocellular carcinoma. In addition, given that immunological responses to core+1/ARFP have been correlated with liver disease severity in chronic HCV patients, we expect that the present work will assist in clarifying the pathophysiological relevance of this protein as a biomarker of disease progression. Copyright © 2018 American Society for Microbiology.

Qualification of CASMO5 / SIMULATE-3K against the SPERT-III E-core cold start-up experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grandi, G.; Moberg, L.

SIMULATE-3K is a three-dimensional kinetic code applicable to LWR Reactivity Initiated Accidents. S3K has been used to calculate several international recognized benchmarks. However, the feedback models in the benchmark exercises are different from the feedback models that SIMULATE-3K uses for LWR reactors. For this reason, it is worth comparing the SIMULATE-3K capabilities for Reactivity Initiated Accidents against kinetic experiments. The Special Power Excursion Reactor Test III was a pressurized-water, nuclear-research facility constructed to analyze the reactor kinetic behavior under initial conditions similar to those of commercial LWRs. The SPERT III E-core resembles a PWR in terms of fuel type, moderator,more » coolant flow rate, and system pressure. The initial test conditions (power, core flow, system pressure, core inlet temperature) are representative of cold start-up, hot start-up, hot standby, and hot full power. The qualification of S3K against the SPERT III E-core measurements is an ongoing work at Studsvik. In this paper, the results for the 30 cold start-up tests are presented. The results show good agreement with the experiments for the reactivity initiated accident main parameters: peak power, energy release and compensated reactivity. Predicted and measured peak powers differ at most by 13%. Measured and predicted reactivity compensations at the time of the peak power differ less than 0.01 $. Predicted and measured energy release differ at most by 13%. All differences are within the experimental uncertainty. (authors)« less

Overview of the Common Core State Standards Initiatives for ELLs. TESOL Issue Brief

ERIC Educational Resources Information Center

TESOL International Association, 2013

2013-01-01

The purpose of this issue brief is to provide a comprehensive overview of the policies behind the Common Core State Standards (CCSS) and to outline some of the initiatives now in place to address the needs of English language learners (ELLs) in relation to the CCSS. This issue brief contains the appendices: (1) Assessment Consortia Time Lines; and…

Accelerator driven sub-critical core

DOEpatents

McIntyre, Peter M; Sattarov, Akhdiyor

2015-03-17

Systems and methods for operating an accelerator driven sub-critical core. In one embodiment, a fission power generator includes a sub-critical core and a plurality of proton beam generators. Each of the proton beam generators is configured to concurrently provide a proton beam into a different area of the sub-critical core. Each proton beam scatters neutrons within the sub-critical core. The plurality of proton beam generators provides aggregate power to the sub-critical core, via the proton beams, to scatter neutrons sufficient to initiate fission in the sub-critical core.

Coated armor system and process for making the same

DOEpatents

Chu, Henry S.; Lillo, Thomas M.; McHugh, Kevin M.

2010-11-23

An armor system and method involves providing a core material and a stream of atomized coating material that comprises a liquid fraction and a solid fraction. An initial layer is deposited on the core material by positioning the core material in the stream of atomized coating material wherein the solid fraction of the stream of atomized coating material is less than the liquid fraction of the stream of atomized coating material on a weight basis. An outer layer is then deposited on the initial layer by positioning the core material in the stream of atomized coating material wherein the solid fraction of the stream of atomized coating material is greater than the liquid fraction of the stream of atomized coating material on a weight basis.

One-pot synthesis of iniferter-bound polystyrene core nanoparticles for the controlled grafting of multilayer shells

NASA Astrophysics Data System (ADS)

Marchyk, Nataliya; Maximilien, Jacqueline; Beyazit, Selim; Haupt, Karsten; Sum Bui, Bernadette Tse

2014-02-01

A novel approach using one-pot synthesis for the production of uniform, iniferter-bound polystyrene core nanoparticles of size 30-40 nm is described. Conventional oil-in-water emulsion polymerisation of styrene and divinylbenzene, combining a hybrid initiation system (thermal and UV), triggered sequentially, was employed to form the surface-bound thiocarbamate iniferters in situ. The iniferter cores were then used as seeds for re-initiating further polymerisation by UV irradiation to produce water-compatible core-shell nanoparticles. Grafting of various shell-types is demonstrated: linear polymers of poly(N-isopropylacrylamide) brushes, crosslinked polymers bearing different surface charges and molecularly imprinted polymers. The shell thickness was readily tuned by varying the monomers' concentration and polymerisation time. Our method is straightforward and in addition, gives access to the preparation of fluorescent seeds and the possibility of grafting nanosized multiple shells. The core-shell nanoparticles were fully characterised by dynamic light scattering, transmission electron microscopy, Fourier transform infrared spectroscopy and microelemental analysis.A novel approach using one-pot synthesis for the production of uniform, iniferter-bound polystyrene core nanoparticles of size 30-40 nm is described. Conventional oil-in-water emulsion polymerisation of styrene and divinylbenzene, combining a hybrid initiation system (thermal and UV), triggered sequentially, was employed to form the surface-bound thiocarbamate iniferters in situ. The iniferter cores were then used as seeds for re-initiating further polymerisation by UV irradiation to produce water-compatible core-shell nanoparticles. Grafting of various shell-types is demonstrated: linear polymers of poly(N-isopropylacrylamide) brushes, crosslinked polymers bearing different surface charges and molecularly imprinted polymers. The shell thickness was readily tuned by varying the monomers' concentration and polymerisation time. Our method is straightforward and in addition, gives access to the preparation of fluorescent seeds and the possibility of grafting nanosized multiple shells. The core-shell nanoparticles were fully characterised by dynamic light scattering, transmission electron microscopy, Fourier transform infrared spectroscopy and microelemental analysis. Electronic supplementary information (ESI) available. See DOI: 10.1039/c3nr05295h

Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative.

PubMed

Kottner, J; Jacobi, L; Hahnel, E; Alam, M; Balzer, K; Beeckman, D; Busard, C; Chalmers, J; Deckert, S; Eleftheriadou, V; Furlan, K; Horbach, S E R; Kirkham, J; Nast, A; Spuls, P; Thiboutot, D; Thorlacius, L; Weller, K; Williams, H C; Schmitt, J

2018-04-01

Results of clinical trials are the most important information source for generating external clinical evidence. The use of different outcomes across trials, which investigate similar interventions for similar patient groups, significantly limits the interpretation, comparability and clinical application of trial results. Core outcome sets (COSs) aim to overcome this limitation. A COS is an agreed standardized collection of outcomes that should be measured and reported in all clinical trials for a specific clinical condition. The Core Outcome Set Initiative within the Cochrane Skin Group (CSG-COUSIN) supports the development of core outcomes in dermatology. In the second CSG-COUSIN meeting held in 2017, 11 COS development groups working on skin diseases presented their current work. The presentations and discussions identified the following overarching methodological challenges for COS development in dermatology: it is not always easy to define the disease focus of a COS; the optimal method for outcome domain identification and level of detail needed to specify such domains is challenging to many; decision rules within Delphi surveys need to be improved; appropriate ways of patient involvement are not always clear. In addition, there appear to be outcome domains that may be relevant as potential core outcome domains for the majority of skin diseases. The close collaboration between methodologists in the Core Outcome Set Initiative and the international Cochrane Skin Group has major advantages for trialists, systematic reviewers and COS developers. © 2018 British Association of Dermatologists.

Common Core State Standards Alignment: Advanced Placement[R]. Research Report 2011-8

ERIC Educational Resources Information Center

Hart, Beth; Carman, Elaine; Luisier, Danielle; Vasavada, Natasha

2011-01-01

The College Board has been a strong advocate for and played an active role in the development of the Common Core State Standards. As part of this collaboration, the College Board helped draft the standards and helped shape the initiative by providing executive guidance on the Common Core Advisory Committee. The goal of the Common Core State…

20 CFR 663.160 - Are there particular core services an individual must receive before receiving intensive services...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Are there particular core services an... Worker Services Through the One-Stop Delivery System § 663.160 Are there particular core services an... minimum, an individual must receive at least one core service, such as an initial assessment or job search...

20 CFR 663.160 - Are there particular core services an individual must receive before receiving intensive services...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Are there particular core services an... Worker Services Through the One-Stop Delivery System § 663.160 Are there particular core services an... minimum, an individual must receive at least one core service, such as an initial assessment or job search...

Comparing the Common Core State Standards in Mathematics and NCTM's "Curriculum Focal Points". Achieving the Common Core

ERIC Educational Resources Information Center

Achieve, Inc., 2010

2010-01-01

Through the Common Core State Standards (CCSS) Initiative, states and territories have collaborated in the development of a common core of standards in English Language Arts and mathematics for grades kindergarten through twelve that are now being adopted by states. Designed not only for the purpose of providing strong, shared expectations, the…

The core learning objectives education model: an approach to the teaching of core concepts in the clinical clerkship.

PubMed

Rapp, David E; Lyon, Mark B; Orvieto, Marcelo A; Zagaja, Gregory P

2005-10-01

The classical approach to the undergraduate medical clerkship has several limitations, including variability of clinical exposure and method of examination. As a result, the clerkship experience does not ensure exposure to and reinforcement of the fundamental concepts of a given specialty. This article reviews the classic approach to clerkship education within the undergraduate medical education. Specific attention is placed on clinical exposure and clerkship examination. We describe the introduction of the Core Learning Objective (CLO) educational model at the University of Chicago Section of Urology. This model is designed to provide an efficient exposure to and evaluation of core clerkship learning objectives. The CLO model has been successfully initiated, focusing on both technical and clinical skill sets. The proposed model has been introduced with positive initial results and should allow for an efficient approach to the teaching and evaluation of core objectives in clerkship education.

Performance potential of gas-core and fusion rockets - A mission applications survey.

NASA Technical Reports Server (NTRS)

Fishbach, L. H.; Willis, E. A., Jr.

1971-01-01

This paper reports an evaluation of the performance potential of five nuclear rocket engines for four mission classes. These engines are: the regeneratively cooled gas-core nuclear rocket; the light bulb gas-core nuclear rocket; the space-radiator cooled gas-core nuclear rocket; the fusion rocket; and an advanced solid-core nuclear rocket which is included for comparison. The missions considered are: earth-to-orbit launch; near-earth space missions; close interplanetary missions; and distant interplanetary missions. For each of these missions, the capabilities of each rocket engine type are compared in terms of payload ratio for the earth launch mission or by the initial vehicle mass in earth orbit for space missions (a measure of initial cost). Other factors which might determine the engine choice are discussed. It is shown that a 60 day manned round trip to Mars is conceivable.-

NFE Core Bibliographies.

ERIC Educational Resources Information Center

Michigan State Univ., East Lansing. Inst. for International Studies in Education.

This collection of core bibliographies, which expands on an initial bibliography published in 1979 of the core resources housed in the Non-Formal Education Information Center at Michigan State University, comprises a basic stock of materials on nonformal education and women in development that have been contributed by development planners,…

Evaluation of external hazards to nuclear power plants in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kimura, C.Y.; Budnitz, R.J.

1987-12-01

The Lawrence Livermore National Laboratory (LLNL) has performed a study of the risk of core damage to nuclear power plants in the United States due to externally initiated events. The broad objective has been to gain an understanding of whether or not each external initiator is among the major potential accident initiators that may pose a threat of severe reactor core damage or of large radioactive release to the environment from the reactor. Four external hazards were investigated in this report. These external hazards are internal fires, high winds/tornadoes, external floods, and transportation accidents. Analysis was based on two figures-of-merit,more » one based on core damage frequency and the other based on the frequency of large radioactive releases. Using these two figures-of-merit as evaluation criteria, it has been feasible to ascertain whether the risk from externally initiated accidents is, or is not, an important contributor to overall risk for the US nuclear power plants studied. This has been accomplished for each initiator separately. 208 refs., 17 figs., 45 tabs.« less

Managing Reform Efforts in Times of Uncertainty: Effects of Principal Support and Leadership on Teachers' Implementation Commitment to Common Core Reform Initiatives

ERIC Educational Resources Information Center

Smith, Lee W.

2016-01-01

The Common Core State Standards (CCSS) require a major shift in instructional practices among teachers. Such changes cause much uncertainty as teachers' roles and identities begin to change. Major school reform creates difficulty for school leaders who must develop teacher support and dedication to 'top-down' reform initiatives in their…

Implementing the Common Core State Standards: Year Three Progress Report from the Great City Schools. Results from 2013-14 School Year

ERIC Educational Resources Information Center

Palacios, Moses; Casserly, Michael; Corcoran, Amanda; Hart, Ray; Simon, Candace; Uzzell, Renata

2014-01-01

Three years ago, the "Council of the Great City Schools" embarked on a multi-year initiative to help its member school districts implement the Common Core State Standards (CCSS). Part of this initiative involves annual surveys of progress urban public school districts were making in implementing the CCSS. With the support of the Bill…

"CanCore": In Canada and around the World

ERIC Educational Resources Information Center

Friesen, Norm

2005-01-01

In this article, the author discusses "CanCore," a learning resource metadata initiative funded by Industry Canada and supported by Athabasca University, Alberta, and TeleUniversite du Quebec, and describes the increasing range of international uses of the "CanCore" metadata for the indexing of learning objects.…

The rotational shear in pre-collapse cores of massive stars

NASA Astrophysics Data System (ADS)

Zilberman, Noa; Gilkis, Avishai; Soker, Noam

2018-02-01

We evolve stellar models to study the rotational profiles of the pre-explosion cores of single massive stars that are progenitors of core collapse supernovae (CCSNe), and find large rotational shear above the iron core that might play an important role in the jet feedback explosion mechanism by amplifying magnetic fields before and after collapse. Initial masses of 15 and 30 M⊙ and various values of the initial rotation velocity are considered, as well as a reduced mass-loss rate along the evolution and the effect of core-envelope coupling through magnetic fields. We find that the rotation profiles just before core collapse differ between models, but share the following properties. (1) There are narrow zones of very large rotational shear adjacent to convective zones. (2) The rotation rate of the inner core is slower than required to form a Keplerian accretion disc. (3) The outer part of the core and the envelope have non-negligible specific angular momentum compared to the last stable orbit around a black hole (BH). Our results suggest the feasibility of magnetic field amplification which might aid a jet-driven explosion leaving behind a neutron star. Alternatively, if the inner core fails in exploding the star, an accretion disc from the outer parts of the core might form and lead to a jet-driven CCSN which leaves behind a BH.

Electron Capture Supernovae from Close Binary Systems

NASA Astrophysics Data System (ADS)

Poelarends, Arend J. T.; Wurtz, Scott; Tarka, James; Cole Adams, L.; Hills, Spencer T.

2017-12-01

We present the first detailed study of the Electron Capture Supernova Channel (ECSN Channel) for a primary star in a close binary star system. Progenitors of ECSN occupy the lower end of the mass spectrum of supernova progenitors and are thought to form the transition between white dwarf progenitors and core-collapse progenitors. The mass range for ECSN from close binary systems is thought to be wider than the range for single stars, because of the effects of mass transfer on the helium core. Using the MESA stellar evolution code, we explored the parameter space of initial primary masses between 8 and 17 {M}⊙ , using a large grid of models. We find that the initial primary mass and the mass transfer evolution are important factors in the final fate of stars in this mass range. Mass transfer due to Roche lobe overflow during and after carbon burning causes the core to cool down so that it avoids neon ignition, even in helium-free cores with masses up to 1.52 {M}⊙ , which in single stars would ignite neon. If the core is able to contract to high enough densities for electron captures to commence, we find that, for the adopted Ledoux convection criterion, the initial mass range for the primary to evolve into an ECSN is between 13.5 and 17.6 {M}⊙ . The mass ratio, initial period, and mass-loss efficiency only marginally affect the predicted ranges.

Industry self-regulation and TV advertising of foods to Australian children.

PubMed

Smithers, Lisa G; Lynch, John W; Merlin, Tracy

2014-05-01

The aim of this study is to examine the amount of non-core (unhealthy) food advertising currently on Australian television (i) during children's programmes and viewing times; (ii) since the introduction of food industry self-regulatory initiatives in 2009; and (iii) whether advertising differs according to signatory status to industry initiatives. We systematically searched PubMed, Embase.com and JSTOR (media/marketing) databases; grey literature; and reference lists of relevant articles for studies published since 2009 that reported on food advertising on Australian television. The title and abstract of 316 articles were screened, yielding 25 articles considered potentially eligible, of which eight met the pre-defined selection criteria. Meta-analysis was not possible because of temporal and methodological differences across studies. The advertising of non-core foods was found to be negligible during programmes with a C-(children's) classification but ranged from 1.5 to 6.5/h during children's peak viewing times. From 2006 to 2011, non-core food advertising decreased by 0.18 advertisements per hour every year, whereas fast food advertising increased by 0.09/h; however, these analyses are based on one study with only five time points. During children's viewing times, signatories to industry initiatives advertise non-core foods at higher rates than non-signatories. Although it is not possible to determine whether advertising has changed since the industry initiatives were introduced, signatories to the initiatives continue to advertise non-core foods at times when many children watch television. Future efforts to reduce children's exposure to food advertising should be focused on advertising during children's peak viewing times rather than by programme classifications. © 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

Architecture of human translation initiation factor 3

PubMed Central

Querol-Audi, Jordi; Sun, Chaomin; Vogan, Jacob M.; Smith, Duane; Gu, Yu; Cate, Jamie; Nogales, Eva

2013-01-01

SUMMARY Eukaryotic translation initiation factor 3 (eIF3) plays a central role in protein synthesis by organizing the formation of the 43S preinitiation complex. Using genetic tag visualization by electron microscopy, we reveal the molecular organization of ten human eIF3 subunits, including an octameric core. The structure of eIF3 bears a close resemblance to that of the proteasome lid, with a conserved spatial organization of eight core subunits containing PCI and MPN domains that coordinate functional interactions in both complexes. We further show that eIF3 subunits a and c interact with initiation factors eIF1 and eIF1A, which control the stringency of start codon selection. Finally, we find that subunit j, which modulates messenger RNA interactions with the small ribosomal subunit, makes multiple independent interactions with the eIF3 octameric core. These results highlight the conserved architecture of eIF3 and how it scaffolds key factors that control translation initiation in higher eukaryotes, including humans. PMID:23623729

Architecture of the RNA polymerase II-Mediator core initiation complex.

PubMed

Plaschka, C; Larivière, L; Wenzeck, L; Seizl, M; Hemann, M; Tegunov, D; Petrotchenko, E V; Borchers, C H; Baumeister, W; Herzog, F; Villa, E; Cramer, P

2015-02-19

The conserved co-activator complex Mediator enables regulated transcription initiation by RNA polymerase (Pol) II. Here we reconstitute an active 15-subunit core Mediator (cMed) comprising all essential Mediator subunits from Saccharomyces cerevisiae. The cryo-electron microscopic structure of cMed bound to a core initiation complex was determined at 9.7 Å resolution. cMed binds Pol II around the Rpb4-Rpb7 stalk near the carboxy-terminal domain (CTD). The Mediator head module binds the Pol II dock and the TFIIB ribbon and stabilizes the initiation complex. The Mediator middle module extends to the Pol II foot with a 'plank' that may influence polymerase conformation. The Mediator subunit Med14 forms a 'beam' between the head and middle modules and connects to the tail module that is predicted to bind transcription activators located on upstream DNA. The Mediator 'arm' and 'hook' domains contribute to a 'cradle' that may position the CTD and TFIIH kinase to stimulate Pol II phosphorylation.

Speech-language pathologists and the Common Core Standards initiative: an opportunity for leadership and organizational change.

PubMed

Dunkle, Jennifer; Flynn, Perry

2012-05-01

The Common Core State Standards initiative within public school education is designed to provide uniform guidelines for academic standards, including more explicit language targets. Speech-language pathologists (SLPs) are highly qualified language experts who may find new leadership roles within their clinical practice using the Common Core Standards. However, determining its usage by SLPs in clinical practice needs to be examined. This article seeks to discover the social context of organizations and organizational change in relation to clinical practice. Specifically, this article presents the diffusion of innovations theory to explain how initiatives move from ideas to institutionalization and the importance of social context in which these initiatives are introduced. Next, the values of both SLPs and organizations will be discussed. Finally, this article provides information on how to affect organizational change through the value of an affirmative, socially based theoretical perspective and methodology, appreciative inquiry. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

[Core muscle chains activation during core exercises determined by EMG-a systematic review].

PubMed

Rogan, Slavko; Riesen, Jan; Taeymans, Jan

2014-10-15

Good core muscles strength is essential for daily life and sports activities. However, the mechanism how core muscles may be effectively triggered by exercises is not yet precisely described in the literature. The aim of this systematic review was to evaluate the rate of activation as measured by electromyography of the ventral, lateral and dorsal core muscle chains during core (trunk) muscle exercises. A total of 16 studies were included. Exercises with a vertical starting position, such as the deadlift or squat activated significantly more core muscles than exercises in the horizontal initial position.

The Core Mass Growth and Stellar Lifetime of Thermally Pulsing Asymptotic Giant Branch Stars

NASA Astrophysics Data System (ADS)

Kalirai, Jason S.; Marigo, Paola; Tremblay, Pier-Emmanuel

2014-02-01

We establish new constraints on the intermediate-mass range of the initial-final mass relation, and apply the results to study the evolution of stars on the thermally pulsing asymptotic giant branch (TP-AGB). These constraints derive from newly discovered (bright) white dwarfs in the nearby Hyades and Praesepe star clusters, including a total of 18 high signal-to-noise ratio measurements with progenitor masses of M initial = 2.8-3.8 M ⊙. We also include a new analysis of existing white dwarfs in the older NGC 6819 and NGC 7789 star clusters, M initial = 1.6 and 2.0 M ⊙. Over this range of initial masses, stellar evolutionary models for metallicity Z initial = 0.02 predict the maximum growth of the core of TP-AGB stars. By comparing the newly measured remnant masses to the robust prediction of the core mass at the first thermal pulse on the AGB (i.e., from stellar interior models), we establish several findings. First, we show that the stellar core mass on the AGB grows rapidly from 10% to 30% for stars with M initial = 1.6 to 2.0 M ⊙. At larger masses, the core-mass growth decreases steadily to ~10% at M initial = 3.4 M ⊙, after which there is a small hint of a upturn out to M initial = 3.8 M ⊙. These observations are in excellent agreement with predictions from the latest TP-AGB evolutionary models in Marigo et al. We also compare to models with varying efficiencies of the third dredge-up and mass loss, and demonstrate that the process governing the growth of the core is largely the stellar wind, while the third dredge-up plays a secondary, but non-negligible role. Based on the new white dwarf measurements, we perform an exploratory calibration of the most popular mass-loss prescriptions in the literature, as well as of the third dredge-up efficiency as a function of the stellar mass. Finally, we estimate the lifetime and the integrated luminosity of stars on the TP-AGB to peak at t ~ 3 Myr and E = 1.2 × 1010 L ⊙ yr for M initial ~ 2 M ⊙ (t ~ 2 Myr for luminosities brighter than the red giant branch tip at log (L/L ⊙) > 3.4), decreasing to t = 0.4 Myr and E = 6.1 × 109 L ⊙ yr for stars with M initial ~ 3.5 M ⊙. The implications of these results are discussed, especially with respect to general studies aimed at characterizing the integrated light output of TP-AGB stars in population synthesis models.

CHAP-2 heat-transfer analysis of the Fort St. Vrain reactor core

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kotas, J.F.; Stroh, K.R.

1983-01-01

The Los Alamos National Laboratory is developing the Composite High-Temperature Gas-Cooled Reactor Analysis Program (CHAP) to provide advanced best-estimate predictions of postulated accidents in gas-cooled reactor plants. The CHAP-2 reactor-core model uses the finite-element method to initialize a two-dimensional temperature map of the Fort St. Vrain (FSV) core and its top and bottom reflectors. The code generates a finite-element mesh, initializes noding and boundary conditions, and solves the nonlinear Laplace heat equation using temperature-dependent thermal conductivities, variable coolant-channel-convection heat-transfer coefficients, and specified internal fuel and moderator heat-generation rates. This paper discusses this method and analyzes an FSV reactor-core accident thatmore » simulates a control-rod withdrawal at full power.« less

Methods of producing armor systems, and armor systems produced using such methods

DOEpatents

Chu, Henry S; Lillo, Thomas M; McHugh, Kevin M

2013-02-19

An armor system and method involves providing a core material and a stream of atomized coating material that comprises a liquid fraction and a solid fraction. An initial layer is deposited on the core material by positioning the core material in the stream of atomized coating material wherein the solid fraction of the stream of atomized coating material is less than the liquid fraction of the stream of atomized coating material on a weight basis. An outer layer is then deposited on the initial layer by positioning the core material in the stream of atomized coating material wherein the solid fraction of the stream of atomized coating material is greater than the liquid fraction of the stream of atomized coating material on a weight basis.

Evaluation of potential severe accidents during low power and shutdown operations at Surry, Unit 1. Volume 5: Analysis of core damage frequency from seismic events during mid-loop operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Budnitz, R.J.; Davis, P.R.; Ravindra, M.K.

1994-08-01

In 1989 the US Nuclear Regulatory Commission (NRC) initiated an extensive program to examine carefully the potential risks during low-power and shutdown operations. The program included two parallel projects, one at Brookhaven National Laboratory studying a pressurized water reactor (Surry Unit 1) and the other at Sandia National Laboratories studying a boiling water reactor (Grand Gulf). Both the Brookhaven and Sandia projects have examined only accidents initiated by internal plant faults--so-called ``internal initiators.`` This project, which has explored the likelihood of seismic-initiated core damage accidents during refueling shutdown conditions, is complementary to the internal-initiator analyses at Brookhaven and Sandia. Thismore » report covers the seismic analysis at Surry Unit 1. All of the many systems modeling assumptions, component non-seismic failure rates, and human error rates that were used in the internal-initiator study at Surry have been adopted here, so that the results of the two studies can be as comparable as possible. Both the Brookhaven study and this study examine only two shutdown plant operating states (POSs) during refueling outages at Surry, called POS 6 and POS 10, which represent mid-loop operation before and after refueling, respectively. This analysis has been limited to work analogous to a level-1 seismic PRA, in which estimates have been developed for the core-damage frequency from seismic events during POSs 6 and 10. The results of the analysis are that the core-damage frequency of earthquake-initiated accidents during refueling outages in POS 6 and POS 10 is found to be low in absolute terms, less than 10{sup {minus}6}/year.« less

Evaluation of potential severe accidents during low power and shutdown operations at Grand Gulf, Unit 1. Volume 5: Analysis of core damage frequency from seismic events for plant operational state 5 during a refueling outage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Budnitz, R.J.; Davis, P.R.; Ravindra, M.K.

In 1989 the US Nuclear Regulatory Commission (NRC) initiated an extensive program to examine carefully the potential risks during low-power and shutdown operations. The program included two parallel projects, one at Sandia National Laboratories studying a boiling water reactor (Grand Gulf), and the other at Brookhaven National Laboratory studying a pressurized water reactor (Surry Unit 1). Both the Sandia and Brookhaven projects have examined only accidents initiated by internal plant faults---so-called ``internal initiators.`` This project, which has explored the likelihood of seismic-initiated core damage accidents during refueling outage conditions, is complementary to the internal-initiator analyses at Brookhaven and Sandia. Thismore » report covers the seismic analysis at Grand Gulf. All of the many systems modeling assumptions, component non-seismic failure rates, and human effort rates that were used in the internal-initiator study at Grand Gulf have been adopted here, so that the results of the study can be as comparable as possible. Both the Sandia study and this study examine only one shutdown plant operating state (POS) at Grand Gulf, namely POS 5 representing cold shutdown during a refueling outage. This analysis has been limited to work analogous to a level-1 seismic PRA, in which estimates have been developed for the core-damage frequency from seismic events during POS 5. The results of the analysis are that the core-damage frequency for earthquake-initiated accidents during refueling outages in POS 5 is found to be quite low in absolute terms, less than 10{sup {minus}7}/year.« less

Precise Maps of RNA Polymerase Reveal How Promoters Direct Initiation and Pausing

PubMed Central

Kwak, Hojoong; Fuda, Nicholas J.; Core, Leighton J.; Lis, John T.

2014-01-01

Transcription regulation occurs frequently through promoter-associated pausing of RNA polymerase II (Pol II). We developed a Precision nuclear Run-On and sequencing assay (PRO-seq) to map the genome-wide distribution of transcriptionally-engaged Pol II at base-pair resolution. Pol II accumulates immediately downstream of promoters, at intron-exon junctions that are efficiently used for splicing, and over 3' poly-adenylation sites. Focused analyses of promoters reveal that pausing is not fixed relative to initiation sites nor is it specified directly by the position of a particular core promoter element or the first nucleosome. Core promoter elements function beyond initiation, and when optimally positioned they act collectively to dictate the position and strength of pausing. We test this ‘Complex Interaction’ model with insertional mutagenesis of the Drosophila Hsp70 core promoter. PMID:23430654

Isolation and functional characterization of TIF-IB, a factor that confers promoter specificity to mouse RNA polymerase I.

PubMed

Schnapp, A; Clos, J; Hädelt, W; Schreck, R; Cvekl, A; Grummt, I

1990-03-25

The murine ribosomal gene promoter contains two cis-acting control elements which operate in concert to promote efficient and accurate transcription initiation by RNA polymerase I. The start site proximal core element which is indispensable for promoter recognition by RNA polymerase I (pol I) encompasses sequences from position -39 to -1. An upstream control element (UCE) which is located between nucleotides -142 and -112 stimulates the efficiency of transcription initiation both in vivo and in vitro. Here we report the isolation and functional characterization of a specific rDNA binding protein, the transcription initiation factor TIF-IB, which specifically interacts with the core region of the mouse ribosomal RNA gene promoter. Highly purified TIF-IB complements transcriptional activity in the presence of two other essential initiation factors TIF-IA and TIF-IC. We demonstrate that the binding efficiency of purified TIF-IB to the core promoter is strongly enhanced by the presence in cis of the UCE. This positive effect of upstream sequences on TIF-IB binding is observed throughout the purification procedure suggesting that the synergistic action of the two distant promoter elements is not mediated by a protein different from TIF-IB. Increasing the distance between both control elements still facilitates stable factor binding but eliminates transcriptional activation. The results demonstrate that TIF-IB binding to the rDNA promoter is an essential early step in the assembly of a functional transcription initiation complex. The subsequent interaction of TIF-IB with other auxiliary transcription initiation factors, however, requires the correct spacing between the UCE and the core promoter element.

78 FR 76328 - Application for Renewal of Special Nuclear Material License SNM-2014 From Tennessee Valley...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-17

... SNM in the form of fully-assembled fuel assemblies that would later form the initial reactor core of WBN2. The SNM in the fuel assemblies is enriched up to 5% in the isotope U-235. The fresh fuel... received the initial core for WBN2. The NRC has not yet issued the OL for the Unit 2 reactor. The...

Core outcome sets in women's and newborn health: a systematic review.

PubMed

Duffy, Jmn; Rolph, R; Gale, C; Hirsch, M; Khan, K S; Ziebland, S; McManus, R J

2017-09-01

Variation in outcome collection and reporting is a serious hindrance to progress in our specialty; therefore, over 80 journals have come together to support the development, dissemination, and implementation of core outcome sets. This study systematically reviewed and characterised registered, progressing, or completed core outcome sets relevant to women's and newborn health. Systematic search using the Core Outcome Measures in Effectiveness Trial initiative and the Core Outcomes in Women's and Newborn Health initiative databases. Registry entries, protocols, systematic reviews, and core outcome sets. Descriptive statistics to describe characteristics and results. There were 49 core outcome sets registered in maternal and newborn health, with the majority registered in 2015 (n = 22; 48%) or 2016 (n = 16; 32%). Benign gynaecology (n = 8; 16%) and newborn health (n = 3; 6%) are currently under-represented. Twenty-four (52%) core outcome sets were funded by international (n = 1; <1%), national (n = 18; 38%), and regional (n = 4; 8%) bodies. Seven protocols were published. Twenty systematic reviews have characterised the inconsistency in outcome reporting across a broad range of relevant healthcare conditions. Four core outcome sets were completed: reconstructive breast surgery (11 outcomes), preterm birth (13 outcomes), epilepsy in pregnancy (29 outcomes), and maternity care (48 outcomes). The quantitative, qualitative, and consensus methods used to develop core outcome sets varied considerably. Core outcome sets are currently being developed across women's and newborn health, although coverage of topics is variable. Development of further infrastructure to develop, disseminate, and implement core outcome sets is urgently required. Forty-nine women's and newborn core outcome sets registered. 50% funded. 7 protocols, 20 systematic reviews, and 4 core outcome sets published. @coreoutcomes @jamesmnduffy. © 2017 Royal College of Obstetricians and Gynaecologists.

Coding, Constant Comparisons, and Core Categories: A Worked Example for Novice Constructivist Grounded Theorists.

PubMed

Giles, Tracey M; de Lacey, Sheryl; Muir-Cochrane, Eimear

2016-01-01

Grounded theory method has been described extensively in the literature. Yet, the varying processes portrayed can be confusing for novice grounded theorists. This article provides a worked example of the data analysis phase of a constructivist grounded theory study that examined family presence during resuscitation in acute health care settings. Core grounded theory methods are exemplified, including initial and focused coding, constant comparative analysis, memo writing, theoretical sampling, and theoretical saturation. The article traces the construction of the core category "Conditional Permission" from initial and focused codes, subcategories, and properties, through to its position in the final substantive grounded theory.

Progress on core outcome sets for critical care research.

PubMed

Blackwood, Bronagh; Marshall, John; Rose, Louise

2015-10-01

Appropriate selection and definition of outcome measures are essential for clinical trials to be maximally informative. Core outcome sets (an agreed, standardized collection of outcomes measured and reported in all trials for a specific clinical area) were developed due to established inconsistencies in trial outcome selection. This review discusses the rationale for, and methods of, core outcome set development, as well as current initiatives in critical care. Recent systematic reviews of reported outcomes and measurement instruments relevant to the critically ill highlight inconsistencies in outcome selection, definition, and measurement, thus establishing the need for core outcome sets. Current critical care initiatives include development of core outcome sets for trials aimed at reducing mechanical ventilation duration; rehabilitation following critical illness; long-term outcomes in acute respiratory failure; and epidemic and pandemic studies of severe acute respiratory infection. Development and utilization of core outcome sets for studies relevant to the critically ill is in its infancy compared to other specialties. Notwithstanding, core outcome set development frameworks and guidelines are available, several sets are in various stages of development, and there is strong support from international investigator-led collaborations including the International Forum for Acute Care Trialists.

Pre-conceptual Development and characterization of an extruded graphite composite fuel for the TREAT Reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luther, Erik; Rooyen, Isabella van; Leckie, Rafael

2015-03-01

In an effort to explore fuel systems that are more robust under accident scenarios, the DOE-NE has identified the need to resume transient testing. The Transient Reactor Test (TREAT) facility has been identified as the preferred option for the resumption of transient testing of nuclear fuel in the United States. In parallel, NNSA’s Global Threat Reduction Initiative (GTRI) Convert program is exploring the needs to replace the existing highly enriched uranium (HEU) core with low enriched uranium (LEU) core. In order to construct a new LEU core, materials and fabrication processes similar to those used in the initial core fabricationmore » must be identified, developed and characterized. In this research, graphite matrix fuel blocks were extruded and materials properties of were measured. Initially the extrusion process followed the historic route; however, the project was expanded to explore methods to increase the graphite content of the fuel blocks and explore modern resins. Materials properties relevant to fuel performance including density, heat capacity and thermal diffusivity were measured. The relationship between process defects and materials properties will be discussed.« less

Prediction and Optimization of Key Performance Indicators in the Production of Stator Core Using a GA-NN Approach

NASA Astrophysics Data System (ADS)

Rajora, M.; Zou, P.; Xu, W.; Jin, L.; Chen, W.; Liang, S. Y.

2017-12-01

With the rapidly changing demands of the manufacturing market, intelligent techniques are being used to solve engineering problems due to their ability to handle nonlinear complex problems. For example, in the conventional production of stator cores, it is relied upon experienced engineers to make an initial plan on the number of compensation sheets to be added to achieve uniform pressure distribution throughout the laminations. Additionally, these engineers must use their experience to revise the initial plans based upon the measurements made during the production of stator core. However, this method yields inconsistent results as humans are incapable of storing and analysing large amounts of data. In this article, first, a Neural Network (NN), trained using a hybrid Levenberg-Marquardt (LM) - Genetic Algorithm (GA), is developed to assist the engineers with the decision-making process. Next, the trained NN is used as a fitness function in an optimization algorithm to find the optimal values of the initial compensation sheet plan with the aim of minimizing the required revisions during the production of the stator core.

Structures of transcription pre-initiation complex with TFIIH and Mediator.

PubMed

Schilbach, S; Hantsche, M; Tegunov, D; Dienemann, C; Wigge, C; Urlaub, H; Cramer, P

2017-11-09

For the initiation of transcription, RNA polymerase II (Pol II) assembles with general transcription factors on promoter DNA to form the pre-initiation complex (PIC). Here we report cryo-electron microscopy structures of the Saccharomyces cerevisiae PIC and PIC-core Mediator complex at nominal resolutions of 4.7 Å and 5.8 Å, respectively. The structures reveal transcription factor IIH (TFIIH), and suggest how the core and kinase TFIIH modules function in the opening of promoter DNA and the phosphorylation of Pol II, respectively. The TFIIH core subunit Ssl2 (a homologue of human XPB) is positioned on downstream DNA by the 'E-bridge' helix in TFIIE, consistent with TFIIE-stimulated DNA opening. The TFIIH kinase module subunit Tfb3 (MAT1 in human) anchors the kinase Kin28 (CDK7), which is mobile in the PIC but preferentially located between the Mediator hook and shoulder in the PIC-core Mediator complex. Open spaces between the Mediator head and middle modules may allow access of the kinase to its substrate, the C-terminal domain of Pol II.

Enhancement of the Accretion of Jupiters Core by a Voluminous Low-Mass Envelope

NASA Technical Reports Server (NTRS)

Lissauer, Jack J.; D'angelo, Gennaro; Weidenschilling, Stuart John; Bodenheimer, Peter; Hubickyj, Olenka

2013-01-01

We present calculations of the early stages of the formation of Jupiter via core nucleated accretion and gas capture. The core begins as a seed body of about 350 kilometers in radius and orbits in a swarm of planetesimals whose initial radii range from 15 meters to 100 kilometers. We follow the evolution of the swarm by accounting for growth and fragmentation, viscous and gravitational stirring, and for drag-induced migration and velocity damping. Gas capture by the core substantially enhances the cross-section of the planet for accretion of small planetesimals. The dust opacity within the atmosphere surrounding the planetary core is computed self-consistently, accounting for coagulation and sedimentation of dust particles released in the envelope as passing planetesimals are ablated. The calculation is carried out at an orbital semi-major axis of 5.2 AU and an initial solids' surface density of 10/g/cm^2 at that distance. The results give a core mass of 7 Earth masses and an envelope mass of approximately 0.1 Earth mass after 500,000 years, at which point the envelope growth rate surpasses that of the core. The same calculation without the envelope gives a core mass of only 4 Earth masses.

Just the Facts: Common Core State Standards

ERIC Educational Resources Information Center

Williams, Cheryl Scott

2012-01-01

In this article, the author talks about the Common Core State Standards and what they mean to teachers and their students. The Common Core State Standards Initiative provides an opportunity for classroom practitioners across the nation to hone their skills, focus on student learning, and ensure that all the students they serve will be working…

Slicing and Dicing the ELA Common Core Standards

ERIC Educational Resources Information Center

Goatley, Virginia

2012-01-01

The English Language Arts Common Core State Standards (ELA CCSS) come at a time when many reading teachers, literacy coaches, and classroom teachers seek more extensive literacy practices than the policy mandates of No Child Left Behind and Reading First. These initiatives placed requirements for instruction in core aspects of reading at the…

Core Leadership: Teacher Leaders and Common Core Implementation in Tennessee

ERIC Educational Resources Information Center

Aspen Institute, 2014

2014-01-01

In the summer of 2012, thousands of teachers across the United States attended several days of professional development workshops. The workshops, which focused on the Common Core State Standards, were part of a Tennessee Department of Education initiative in teacher leadership. The department recruited and trained 200 highly-effective teachers to…

Response to Anthony J. Palmer, "A Philosophical View of the General Education Core"

ERIC Educational Resources Information Center

Schuler, Nico

2004-01-01

Anthony J. Palmer's paper continues an absolutely necessary discussion on the general education core curriculum for American undergraduate students. Initially, Palmer summarized the global conditions with which we are presently confronted. This discussion led him to the reexamination of the general education core at the undergraduate level. The…

Weakly and strongly coupled Belousov-Zhabotinsky patterns.

PubMed

Weiss, Stephan; Deegan, Robert D

2017-02-01

We investigate experimentally and numerically the synchronization of two-dimensional spiral wave patterns in the Belousov-Zhabotinsky reaction due to point-to-point coupling of two separate domains. Different synchronization modalities appear depending on the coupling strength and the initial patterns in each domain. The behavior as a function of the coupling strength falls into two qualitatively different regimes. The weakly coupled regime is characterized by inter-domain interactions that distorted but do not break wave fronts. Under weak coupling, spiral cores are pushed around by wave fronts in the other domain, resulting in an effective interaction between cores in opposite domains. In the case where each domain initially contains a single spiral, the cores form a bound pair and orbit each other at quantized distances. When the starting patterns consist of multiple randomly positioned spiral cores, the number of cores decreases with time until all that remains are a few cores that are synchronized with a partner in the other domain. The strongly coupled regime is characterized by interdomain interactions that break wave fronts. As a result, the wave patterns in both domains become identical.

Weakly and strongly coupled Belousov-Zhabotinsky patterns

NASA Astrophysics Data System (ADS)

Weiss, Stephan; Deegan, Robert D.

2017-02-01

We investigate experimentally and numerically the synchronization of two-dimensional spiral wave patterns in the Belousov-Zhabotinsky reaction due to point-to-point coupling of two separate domains. Different synchronization modalities appear depending on the coupling strength and the initial patterns in each domain. The behavior as a function of the coupling strength falls into two qualitatively different regimes. The weakly coupled regime is characterized by inter-domain interactions that distorted but do not break wave fronts. Under weak coupling, spiral cores are pushed around by wave fronts in the other domain, resulting in an effective interaction between cores in opposite domains. In the case where each domain initially contains a single spiral, the cores form a bound pair and orbit each other at quantized distances. When the starting patterns consist of multiple randomly positioned spiral cores, the number of cores decreases with time until all that remains are a few cores that are synchronized with a partner in the other domain. The strongly coupled regime is characterized by interdomain interactions that break wave fronts. As a result, the wave patterns in both domains become identical.

A Study of THT Cold Cores Population in the Star-Forming Region in Serpens

NASA Astrophysics Data System (ADS)

Fiorellino, Eleonora

2017-11-01

The purpose of this work is to produce the Core Mass Function (CMF) of the Serpens star-forming region and confront it with the Initial Mass Function (IMF), the statistical distribution of initial star mass. As Testi & Sergent (1998) discovered, the power-law index of the slope of the CMF is very close to the one of the Salpeter's IMF (Salpeter, 1955): dN/dM / M2.35. This strongly suggests that the stellar IMF results from the fragmentation process in turbulent cloud cores rather than from stellar accretion mechanisms and gives a huge contribute to undestanding the star formation. For this work, we started from the data delivered by the European satellite Herschel and produced the maps of the Serpens with Unimap code (Piazzo et al, 2015). Hence we obtained a core catalogue with two different softwares getsources (Men'shchikov et al, 2012) and CuTEx (Molinari et al, 2011) and we eliminated from it any source that is not a core. A full discussion of the cores physical propreties as well as the whole region is under preparation.

Core Promoter Functions in the Regulation of Gene Expression of Drosophila Dorsal Target Genes*

PubMed Central

Zehavi, Yonathan; Kuznetsov, Olga; Ovadia-Shochat, Avital; Juven-Gershon, Tamar

2014-01-01

Developmental processes are highly dependent on transcriptional regulation by RNA polymerase II. The RNA polymerase II core promoter is the ultimate target of a multitude of transcription factors that control transcription initiation. Core promoters consist of core promoter motifs, e.g. the initiator, TATA box, and the downstream core promoter element (DPE), which confer specific properties to the core promoter. Here, we explored the importance of core promoter functions in the dorsal-ventral developmental gene regulatory network. This network includes multiple genes that are activated by different nuclear concentrations of Dorsal, an NFκB homolog transcription factor, along the dorsal-ventral axis. We show that over two-thirds of Dorsal target genes contain DPE sequence motifs, which is significantly higher than the proportion of DPE-containing promoters in Drosophila genes. We demonstrate that multiple Dorsal target genes are evolutionarily conserved and functionally dependent on the DPE. Furthermore, we have analyzed the activation of key Dorsal target genes by Dorsal, as well as by another Rel family transcription factor, Relish, and the dependence of their activation on the DPE motif. Using hybrid enhancer-promoter constructs in Drosophila cells and embryo extracts, we have demonstrated that the core promoter composition is an important determinant of transcriptional activity of Dorsal target genes. Taken together, our results provide evidence for the importance of core promoter composition in the regulation of Dorsal target genes. PMID:24634215

Advertising to children initiatives have not reduced unhealthy food advertising on Australian television.

PubMed

Watson, Wendy L; Lau, Vivien; Wellard, Lyndal; Hughes, Clare; Chapman, Kathryn

2017-12-01

In response to rising childhood obesity rates, the Australian food industry implemented two initiatives in 2009 to reduce the marketing of unhealthy food to children. This study evaluated the efficacy of these initiatives on the rate of unhealthy food advertising to children on Australian television. The rates of food advertisements on three free-to-air commercial television channels and a youth-oriented digital channel in Sydney, Australia were analysed over 2 weekdays (16 h) and two weekend days (22 h). Advertisements were categorized according to the healthiness of foods advertised (non-core, core, miscellaneous) and signatory status to the food industry advertising initiatives. Total food advertising rates for the three channels increased from 5.5/h in 2011 to 7.3/h in 2015, due to an increase of 0.8/h for both core and miscellaneous foods. The rate of non-core food advertisements in 2015 (3.1/h) was similar to 2011 (3.0/h). The youth-oriented channel had fewer total food advertisements (3.7/h versus 7.3/h) but similar fast-food advertisement rates (1.3/h versus 1.3/h). There was no change in the rate of unhealthy food advertising since 2011, suggesting minimal impact of the current food industry initiatives on reducing children's exposure to unhealthy food advertising. © The Author 2017. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Observed Luminosity Spread in Young Clusters and FU Ori Stars: A Unified Picture

NASA Astrophysics Data System (ADS)

Baraffe, I.; Vorobyov, E.; Chabrier, G.

2012-09-01

The idea that non-steady accretion during the embedded phase of protostar evolution can produce the observed luminosity spread in the Herzsprung-Russell diagram (HRD) of young clusters has recently been called into question. Observations of FU Ori, for instance, suggest an expansion of the star during strong accretion events, whereas the luminosity spread implies a contraction of the accreting objects, decreasing their radiating surface. In this paper, we present a global scenario based on calculations coupling episodic accretion histories derived from numerical simulations of collapsing cloud prestellar cores of various masses and subsequent protostar evolution. Our calculations show that, assuming an initial protostar mass Mi ~ 1 M Jup, typical of the second Larson's core, both the luminosity spread in the HRD and the inferred properties of FU Ori events (mass, radius, accretion rate) can be explained by this scenario, providing two conditions. First, there must be some variation within the fraction of accretion energy absorbed by the protostar during the accretion process. Second, the range of this variation should increase with increasing accretion burst intensity and thus with the initial core mass and final star mass. The numerical hydrodynamics simulations of collapsing cloud prestellar cores indeed show that the intensity of the accretion bursts correlates with the mass and initial angular momentum of the prestellar core. Massive prestellar cores with high initial angular momentum are found to produce intense bursts characteristic of FU Ori-like events. Our results thus suggest a link between the burst intensities and the fraction of accretion energy absorbed by the protostar, with some threshold in the accretion rate, of the order of 10-5 M ⊙ yr-1, delimitating the transition from "cold" to "hot" accretion. Such a transition might reflect a change in the accretion geometry with increasing accretion rate, i.e., a transition from magnetospheric or thin-disk to thick-disk accretion, or in the magnetospheric interaction between the star and the disk. Conversely, the luminosity spread can also be explained by a variation of the initial protostar mass within the ~1-5 M Jup range, although it is unclear for now whether such a spread among the second Larson's core can be produced during the prestellar core second collapse. This unified picture confirms the idea that early accretion during protostar and proto-brown dwarf formation/evolution can explain the observed luminosity spread in young clusters without invoking any significant age spread, and that the concept of a well-defined birthline does not apply for low-mass objects. Finally, we examine the impact of accretion on the determination of the initial mass function in young clusters.

Stellar evolution of high mass based on the Ledoux criterion for convection

NASA Technical Reports Server (NTRS)

Stothers, R.; Chin, C.

1972-01-01

Theoretical evolutionary sequences of models for stars of 15 and 30 solar masses were computed from the zero-age main sequence to the end of core helium burning. During the earliest stages of core helium depletion, the envelope rapidly expands into the red-supergiant configuration. At 15 solar mass, a blue loop on the H-R diagram ensues if the initial metals abundance, initial helium abundance, or C-12 + alpha particle reaction rate is sufficiently large, or if the 3-alpha reaction rate is sufficiently small. These quantities affect the opacity of the base of the outer convection zone, the mass of the core, and the thermal properties of the core. The blue loop occurs abruptly and fully developed when the critical value of any of these quantities is exceeded, and the effective temperature range and fraction of the lifetime of core helium burning during the slow phase of the blue loop vary surprisingly little. At 30 solar mass no blue loop occurs for any reasonable set of input parameters.

Residues in the membrane-spanning domain core modulate conformation and fusogenicity of the HIV-1 envelope glycoprotein

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shang Liang; Hunter, Eric, E-mail: eric.hunter2@emory.ed

2010-09-01

The membrane-spanning domain (MSD) of human immunodeficiency virus type I (HIV-1) envelope glycoprotein (Env) is critical for its biological activity. Initial studies have defined an almost invariant 'core' structure in the MSD and demonstrated that it is crucial for anchoring Env in the membrane and virus entry. We show here that amino acid substitutions in the MSD 'core' do not influence specific virus-cell attachment, nor CD4 receptor and CXCR4 coreceptor recognition by Env. However, substitutions within the MSD 'core' delayed the kinetics and reduced the efficiency of cell-cell fusion mediated by Env. Although we observed no evidence that membrane fusionmore » mediated by the MSD core mutants was arrested at a hemifusion stage, impaired Env fusogenicity was correlated with minor conformational changes in the V2, C1, and C5 regions in gp120 and the immunodominant loop in gp41. These changes could delay initiation of the conformational changes required in the fusion process.« less

School Administrators' Leadership Challenges Implementing the Common Core State Standards Initiative in Schools with a Majority African American Student Population: A Narrative Inquiry

ERIC Educational Resources Information Center

Merkel, Kristy M.

2017-01-01

The Common Core State Standards Initiative (CCSSI) has been adopted by forty-two states, the District of Columbia, four territories, and the Department of defense Education Activity (DoDeA). The intent of the CCSSI is to ensure that all students graduate from high school with the skills and knowledge necessary to succeed in college, career, and…

Core-shell microparticles for protein sequestration and controlled release of a protein-laden core.

PubMed

Rinker, Torri E; Philbrick, Brandon D; Temenoff, Johnna S

2017-07-01

Development of multifunctional biomaterials that sequester, isolate, and redeliver cell-secreted proteins at a specific timepoint may be required to achieve the level of temporal control needed to more fully regulate tissue regeneration and repair. In response, we fabricated core-shell heparin-poly(ethylene-glycol) (PEG) microparticles (MPs) with a degradable PEG-based shell that can temporally control delivery of protein-laden heparin MPs. Core-shell MPs were fabricated via a re-emulsification technique and the number of heparin MPs per PEG-based shell could be tuned by varying the mass of heparin MPs in the precursor PEG phase. When heparin MPs were loaded with bone morphogenetic protein-2 (BMP-2) and then encapsulated into core-shell MPs, degradable core-shell MPs initiated similar C2C12 cell alkaline phosphatase (ALP) activity as the soluble control, while non-degradable core-shell MPs initiated a significantly lower response (85+19% vs. 9.0+4.8% of the soluble control, respectively). Similarly, when degradable core-shell MPs were formed and then loaded with BMP-2, they induced a ∼7-fold higher C2C12 ALP activity than the soluble control. As C2C12 ALP activity was enhanced by BMP-2, these studies indicated that degradable core-shell MPs were able to deliver a bioactive, BMP-2-laden heparin MP core. Overall, these dynamic core-shell MPs have the potential to sequester, isolate, and then redeliver proteins attached to a heparin core to initiate a cell response, which could be of great benefit to tissue regeneration applications requiring tight temporal control over protein presentation. Tissue repair requires temporally controlled presentation of potent proteins. Recently, biomaterial-mediated binding (sequestration) of cell-secreted proteins has emerged as a strategy to harness the regenerative potential of naturally produced proteins, but this strategy currently only allows immediate amplification and re-delivery of these signals. The multifunctional, dynamic core-shell heparin-PEG microparticles presented here overcome this limitation by sequestering proteins through a PEG-based shell onto a protein-protective heparin core, temporarily isolating bound proteins from the cellular microenvironment, and re-delivering proteins only after degradation of the PEG-based shell. Thus, these core-shell microparticles have potential to be a novel tool to harness and isolate proteins produced in the cellular environment and then control when proteins are re-introduced for the most effective tissue regeneration and repair. Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

The treatment of mixing in core helium-burning models - III. Suppressing core breathing pulses with a new constraint on overshoot

NASA Astrophysics Data System (ADS)

Constantino, Thomas; Campbell, Simon W.; Lattanzio, John C.

2017-12-01

Theoretical predictions for the core helium burning phase of stellar evolution are highly sensitive to the uncertain treatment of mixing at convective boundaries. In the last few years, interest in constraining the uncertain structure of their deep interiors has been renewed by insights from asteroseismology. Recently, Spruit proposed a limit for the rate of growth of helium-burning convective cores based on the higher buoyancy of material ingested from outside the convective core. In this paper we test the implications of such a limit for stellar models with a range of initial mass and metallicity. We find that the constraint on mixing beyond the Schwarzschild boundary has a significant effect on the evolution late in core helium burning, when core breathing pulses occur and the ingestion rate of helium is fastest. Ordinarily, core breathing pulses prolong the core helium burning lifetime to such an extent that models are at odds with observations of globular cluster populations. Across a wide range of initial stellar masses (0.83 ≤ M/M⊙ ≤ 5), applying the Spruit constraint reduces the core helium burning lifetime because core breathing pulses are either avoided or their number and severity reduced. The constraint suggested by Spruit therefore helps to resolve significant discrepancies between observations and theoretical predictions. Specifically, we find improved agreement for R2 (the observed ratio of asymptotic giant branch to horizontal branch stars in globular clusters), the luminosity difference between these two groups, and in asteroseismology, the mixed-mode period spacing detected in red clump stars in the Kepler field.

Improving Undergraduate Online Retention through Gated Advisement and Redundant Communication

ERIC Educational Resources Information Center

Clay, Melanie N.; Rowland, Stacey; Packard, Abbot

2009-01-01

The University of West Georgia implemented a successful research-based initiative, Project DEW (Developing eCore Winners) to improve retention in its eCore courses. eCore courses are those offered through a collaborative University System of Georgia program, and includes courses required to complete the first two years of an undergraduate degree.…

Pd-Ag chronometry of IVA iron meteorites and the crystallization and cooling of a protoplanetary core

DOE PAGES

Matthes, M.; Fischer-Godde, M.; Kruijer, T. S.; ...

2017-09-07

To constrain the timescales and processes involved in the crystallization and cooling of protoplanetary cores, we examined the Pd-Ag isotope systematics of the IVA iron meteorites Muonionalusta and Gibeon. A Pd-Ag isochron for Muonionalusta provides an initial 107Pd/ 108Pd = (2.57 ± 0.07) × 10 -5. The three metal samples analyzed from Gibeon plot below the Muonionalusta isochron, but these samples also show significant effects of cosmic ray-induced neutron capture reactions, as is evident from 196Pt excesses in the Gibeon samples. After correction for neutron capture effects on Ag isotopes, the Gibeon samples plot on the Muonionalusta isochron, indicating thatmore » these two IVA irons have indistinguishable initial 107Pd/ 108Pd. Collectively, the Pd-Ag data indicate cooling of the IVA core below Pd-Ag closure between 2.9 ± 0.4 Ma and 8.9 ± 0.6 Ma after CAI formation, where this age range reflects uncertainties in the initial 107Pd/ 108Pd ratios of the solar system, which in turn result from uncertainties in the Pb-Pb age of Muonionalusta. The Ag isotopic data indicate that the IVA core initially evolved with a modestly elevated Pd/Ag, but the low Ag concentrations measured for some metal samples indicate derivation from a source with much lower Ag contents and, hence, higher Pd/Ag. These contrasting observations can be reconciled if the IVA irons crystallized from an initially more Ag-rich core, followed by extraction of Fe-S melts during compaction of the nearly solidified core. Owing to its strong tendency to partition into Fe-S melts, Ag was removed from the IVA core during compaction, leading to the very low Ag concentration observed in metal samples of IVA irons. Alternatively, Ag was lost by evaporation from a still molten metallic body just prior to the onset of crystallization. The Pd-Ag isotopic data indicate that Muonionalusta cooled at >500 K/Ma through the Pd-Ag closure temperature of ~900 K, consistent with the rapid cooling inferred from metallographic cooling rates for IVA irons. Finally, combined, these observations are consistent with cooling of IVA irons in a metallic body with little or no silicate mantle.« less

Pd-Ag chronometry of IVA iron meteorites and the crystallization and cooling of a protoplanetary core

NASA Astrophysics Data System (ADS)

Matthes, M.; Fischer-Gödde, M.; Kruijer, T. S.; Kleine, T.

2018-01-01

To constrain the timescales and processes involved in the crystallization and cooling of protoplanetary cores, we examined the Pd-Ag isotope systematics of the IVA iron meteorites Muonionalusta and Gibeon. A Pd-Ag isochron for Muonionalusta provides an initial 107Pd/108Pd = (2.57 ± 0.07) × 10-5. The three metal samples analyzed from Gibeon plot below the Muonionalusta isochron, but these samples also show significant effects of cosmic ray-induced neutron capture reactions, as is evident from 196Pt excesses in the Gibeon samples. After correction for neutron capture effects on Ag isotopes, the Gibeon samples plot on the Muonionalusta isochron, indicating that these two IVA irons have indistinguishable initial 107Pd/108Pd. Collectively, the Pd-Ag data indicate cooling of the IVA core below Pd-Ag closure between 2.9 ± 0.4 Ma and 8.9 ± 0.6 Ma after CAI formation, where this age range reflects uncertainties in the initial 107Pd/108Pd ratios of the solar system, which in turn result from uncertainties in the Pb-Pb age of Muonionalusta. The Ag isotopic data indicate that the IVA core initially evolved with a modestly elevated Pd/Ag, but the low Ag concentrations measured for some metal samples indicate derivation from a source with much lower Ag contents and, hence, higher Pd/Ag. These contrasting observations can be reconciled if the IVA irons crystallized from an initially more Ag-rich core, followed by extraction of Fe-S melts during compaction of the nearly solidified core. Owing to its strong tendency to partition into Fe-S melts, Ag was removed from the IVA core during compaction, leading to the very low Ag concentration observed in metal samples of IVA irons. Alternatively, Ag was lost by evaporation from a still molten metallic body just prior to the onset of crystallization. The Pd-Ag isotopic data indicate that Muonionalusta cooled at >500 K/Ma through the Pd-Ag closure temperature of ∼900 K, consistent with the rapid cooling inferred from metallographic cooling rates for IVA irons. Combined, these observations are consistent with cooling of IVA irons in a metallic body with little or no silicate mantle.

Pd-Ag chronometry of IVA iron meteorites and the crystallization and cooling of a protoplanetary core

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matthes, M.; Fischer-Godde, M.; Kruijer, T. S.

To constrain the timescales and processes involved in the crystallization and cooling of protoplanetary cores, we examined the Pd-Ag isotope systematics of the IVA iron meteorites Muonionalusta and Gibeon. A Pd-Ag isochron for Muonionalusta provides an initial 107Pd/ 108Pd = (2.57 ± 0.07) × 10 -5. The three metal samples analyzed from Gibeon plot below the Muonionalusta isochron, but these samples also show significant effects of cosmic ray-induced neutron capture reactions, as is evident from 196Pt excesses in the Gibeon samples. After correction for neutron capture effects on Ag isotopes, the Gibeon samples plot on the Muonionalusta isochron, indicating thatmore » these two IVA irons have indistinguishable initial 107Pd/ 108Pd. Collectively, the Pd-Ag data indicate cooling of the IVA core below Pd-Ag closure between 2.9 ± 0.4 Ma and 8.9 ± 0.6 Ma after CAI formation, where this age range reflects uncertainties in the initial 107Pd/ 108Pd ratios of the solar system, which in turn result from uncertainties in the Pb-Pb age of Muonionalusta. The Ag isotopic data indicate that the IVA core initially evolved with a modestly elevated Pd/Ag, but the low Ag concentrations measured for some metal samples indicate derivation from a source with much lower Ag contents and, hence, higher Pd/Ag. These contrasting observations can be reconciled if the IVA irons crystallized from an initially more Ag-rich core, followed by extraction of Fe-S melts during compaction of the nearly solidified core. Owing to its strong tendency to partition into Fe-S melts, Ag was removed from the IVA core during compaction, leading to the very low Ag concentration observed in metal samples of IVA irons. Alternatively, Ag was lost by evaporation from a still molten metallic body just prior to the onset of crystallization. The Pd-Ag isotopic data indicate that Muonionalusta cooled at >500 K/Ma through the Pd-Ag closure temperature of ~900 K, consistent with the rapid cooling inferred from metallographic cooling rates for IVA irons. Finally, combined, these observations are consistent with cooling of IVA irons in a metallic body with little or no silicate mantle.« less

Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay

PubMed Central

2013-01-01

Background Uncoating of the HIV-1 core plays a critical role during early post-fusion stages of infection but is poorly understood. Microscopy-based assays are unable to easily distinguish between intact and partially uncoated viral cores. Results In this study, we used 5-ethynyl uridine (EU) to label viral-associated RNA during HIV production. At early time points after infection with EU-labeled virions, the viral-associated RNA was stained with an EU-specific dye and was detected by confocal microscopy together with viral proteins. We observed that detection of the viral-associated RNA was specific for EU-labeled virions, was detected only after viral fusion with target cells, and occurred after an initial opening of the core. In vitro staining of cores showed that the opening of the core allowed the small molecule dye, but not RNase A or antibodies, inside. Also, staining of the viral-associated RNA, which is co-localized with nucleocapsid, decays over time after viral infection. The decay rate of RNA staining is dependent on capsid (CA) stability, which was altered by CA mutations or a small molecule inducer of HIV-1 uncoating. While the staining of EU-labeled RNA was not affected by inhibition of reverse transcription, the kinetics of core opening of different CA mutants correlated with initiation of reverse transcription. Analysis of the E45A CA mutant suggests that initial core opening is independent of complete capsid disassembly. Conclusions Taken together, our results establish a novel RNA accessibility-based assay that detects an early event in HIV-1 uncoating and can be used to further define this process. PMID:23835323

Delay-time distribution of core-collapse supernovae with late events resulting from binary interaction

NASA Astrophysics Data System (ADS)

Zapartas, E.; de Mink, S. E.; Izzard, R. G.; Yoon, S.-C.; Badenes, C.; Götberg, Y.; de Koter, A.; Neijssel, C. J.; Renzo, M.; Schootemeijer, A.; Shrotriya, T. S.

2017-05-01

Most massive stars, the progenitors of core-collapse supernovae, are in close binary systems and may interact with their companion through mass transfer or merging. We undertake a population synthesis study to compute the delay-time distribution of core-collapse supernovae, that is, the supernova rate versus time following a starburst, taking into account binary interactions. We test the systematic robustness of our results by running various simulations to account for the uncertainties in our standard assumptions. We find that a significant fraction, %, of core-collapse supernovae are "late", that is, they occur 50-200 Myr after birth, when all massive single stars have already exploded. These late events originate predominantly from binary systems with at least one, or, in most cases, with both stars initially being of intermediate mass (4-8 M⊙). The main evolutionary channels that contribute often involve either the merging of the initially more massive primary star with its companion or the engulfment of the remaining core of the primary by the expanding secondary that has accreted mass at an earlier evolutionary stage. Also, the total number of core-collapse supernovae increases by % because of binarity for the same initial stellar mass. The high rate implies that we should have already observed such late core-collapse supernovae, but have not recognized them as such. We argue that φ Persei is a likely progenitor and that eccentric neutron star - white dwarf systems are likely descendants. Late events can help explain the discrepancy in the delay-time distributions derived from supernova remnants in the Magellanic Clouds and extragalactic type Ia events, lowering the contribution of prompt Ia events. We discuss ways to test these predictions and speculate on the implications for supernova feedback in simulations of galaxy evolution.

Earthquake Signatures in the Modern Sediment Record of Prince William Sound, Alaska

NASA Astrophysics Data System (ADS)

Marshall, N. R.; Kuehl, S. A.; Dellapenna, T. M.; Miller, E. J.

2016-02-01

Geochemical signatures of earthquake-generated sediment gravity flows are investigated using X-ray fluorescence core scanning on a suite of sediment cores from Prince William Sound, Alaska. This study focused on the development of geochemical proxies for earthquake deposits with an emphasis on interpreting deposits initiated from large subduction earthquakes. A north-south transect of sediment cores from Prince William Sound, between Hinchinbrook Island and the Columbia Glacier, was used to examine a record of earthquakes in this tectonically active region for the past century. The sediments in Prince William Sound are sourced from two geologically distinct regions: the metamorphosed turbidites of coastal Prince William Sound, and the Copper River Basin that contains a significant amount of volcanic rocks. Geochemical studies of sediment cores and end-member sediment samples using X-ray fluorescence and inductively coupled plasma mass spectrometry allowed for the development of geochemical proxies for sediment provenance during the past 100 years. Downcore peaks in Sr/Pb are indicative of Copper River Basin sediments, whereas peaks in K/Ca are indicative of inputs of Prince William Sound sediments. Large subduction earthquakes in northern Prince William Sound initiate gravity flows of Prince William Sound provenance into the deep channel. Particularly robust provenance signatures are seen in the northernmost cores in the core transect, which are closer to the earthquake epicenters and the Columbia Glacier source region. The ages of the deposits, from core-averaged 210Pb sediment accumulation rates, correspond to large earthquakes that occurred in 1912, 1964, and 1983. A similar deposit from 1895 in northern Prince William Sound, prior to historical earthquake records, may have also been initiated from a large earthquake in the 1890's.

Massive Infrared-Quiet Dense Cores: Unveiling the Initial Conditions of High-Mass Star Formation

NASA Astrophysics Data System (ADS)

Motte, F.; Bontemps, S.; Schneider, N.; Schilke, P.; Menten, K. M.

2008-05-01

As Th. Henning said at the conference, cold precursors of high-mass stars are now ``hot topics''. We here propose some observational criteria to identify massive infrared-quiet dense cores which can host the high-mass analogs of Class~0 protostars and pre-stellar condensations. We also show how far-infrared to millimeter imaging surveys of entire complexes forming OB stars are starting to unveil the initial conditions of high-mass star formation.

Structure, Dynamics, and Deuterium Fractionation of Massive Pre-stellar Cores

NASA Astrophysics Data System (ADS)

Goodson, Matthew D.; Kong, Shuo; Tan, Jonathan C.; Heitsch, Fabian; Caselli, Paola

2016-12-01

High levels of deuterium fraction in N2H+ are observed in some pre-stellar cores. Single-zone chemical models find that the timescale required to reach observed values ({D}{frac}{{{N}}2{{{H}}}+}\\equiv {{{N}}}2{{{D}}}+/{{{N}}}2{{{H}}}+≳ 0.1) is longer than the free-fall time, possibly 10 times longer. Here, we explore the deuteration of turbulent, magnetized cores with 3D magnetohydrodynamics simulations. We use an approximate chemical model to follow the growth in abundances of N2H+ and N2D+. We then examine the dynamics of the core using each tracer for comparison to observations. We find that the velocity dispersion of the core as traced by N2D+ appears slightly sub-virial compared to predictions of the Turbulent Core Model of McKee & Tan, except at late times just before the onset of protostar formation. By varying the initial mass surface density, the magnetic energy, the chemical age, and the ortho-to-para ratio of H2, we also determine the physical and temporal properties required for high deuteration. We find that low initial ortho-to-para ratios (≲ 0.01) and/or multiple free-fall times (≳ 3) of prior chemical evolution are necessary to reach the observed values of deuterium fraction in pre-stellar cores.

Locations and descriptions of gravity, box, and push cores collected in San Francisco Bay between January and February, 1990 and 1991

USGS Publications Warehouse

Anima, Roberto J.; Clifton, H. Edward; Reiss, Carol; Wong, Florence L.

2005-01-01

A project to study San Francisco Bay sediments collected over 300 sediment gravity cores; six push cores, and three box cores in San Francisco Bay during the years 1990-91. The purpose of the sampling effort is to establish a database on the Holocene sediment history of the bay. The samples described and mapped are the first effort to catalog and present the data collected. Thus far the cores have been utilized in various cooperative studies with state colleges and universities, and other USGS divisions. These cores serve as a base for ongoing multidisciplinary studies. The sediment studies project has initiated subsequent coring efforts within the bay using refined coring techniques to attain deeper cores.

Tuning the synthesis of platinum-copper nanoparticles with a hollow core and porous shell for the selective hydrogenation of furfural to furfuryl alcohol

NASA Astrophysics Data System (ADS)

Huang, Shuangshuang; Yang, Nating; Wang, Shibin; Sun, Yuhan; Zhu, Yan

2016-07-01

Pt-Cu nanoparticles constructed with a hollow core and porous shell have been synthesized in which Pt-Cu cages with multiporous outermost shells are formed at the initial stage and then the Pt and Cu atoms in solution continuously fed these hollow-core of cages by passing through the porous tunnels of the outermost shells, finally leading to the formation of hollow structures with different sizes. Furthermore, these hollow-core Pt-Cu nanoparticles are more effective than the solid-core Pt-Cu nanoparticles for the catalytic hydrogenation of furfural toward furfuryl alcohol. The former can achieve almost 100% conversion of furfural with 100% selectivity toward the alcohol.Pt-Cu nanoparticles constructed with a hollow core and porous shell have been synthesized in which Pt-Cu cages with multiporous outermost shells are formed at the initial stage and then the Pt and Cu atoms in solution continuously fed these hollow-core of cages by passing through the porous tunnels of the outermost shells, finally leading to the formation of hollow structures with different sizes. Furthermore, these hollow-core Pt-Cu nanoparticles are more effective than the solid-core Pt-Cu nanoparticles for the catalytic hydrogenation of furfural toward furfuryl alcohol. The former can achieve almost 100% conversion of furfural with 100% selectivity toward the alcohol. Electronic supplementary information (ESI) available. See DOI: 10.1039/c6nr03894h

Lessons Learned From a Community–Academic Initiative: The Development of a Core Competency–Based Training for Community–Academic Initiative Community Health Workers

PubMed Central

Matos, Sergio; Kapadia, Smiti; Islam, Nadia; Cusack, Arthur; Kwong, Sylvia; Trinh-Shevrin, Chau

2012-01-01

Objectives. Despite the importance of community health workers (CHWs) in strategies to reduce health disparities and the call to enhance their roles in research, little information exists on how to prepare CHWs involved in community–academic initiatives (CAIs). Therefore, the New York University Prevention Research Center piloted a CAI–CHW training program. Methods. We applied a core competency framework to an existing CHW curriculum and bolstered the curriculum to include research-specific sessions. We employed diverse training methods, guided by adult learning principles and popular education philosophy. Evaluation instruments assessed changes related to confidence, intention to use learned skills, usefulness of sessions, and satisfaction with the training. Results. Results demonstrated that a core competency–based training can successfully affect CHWs’ perceived confidence and intentions to apply learned content, and can provide a larger social justice context of their role and work. Conclusions. This program demonstrates that a core competency–based framework coupled with CAI-research–specific skill sessions (1) provides skills that CAI–CHWs intend to use, (2) builds confidence, and (3) provides participants with a more contextualized view of client needs and CHW roles. PMID:22594730

Lessons learned from a community-academic initiative: the development of a core competency-based training for community-academic initiative community health workers.

PubMed

Ruiz, Yumary; Matos, Sergio; Kapadia, Smiti; Islam, Nadia; Cusack, Arthur; Kwong, Sylvia; Trinh-Shevrin, Chau

2012-12-01

Despite the importance of community health workers (CHWs) in strategies to reduce health disparities and the call to enhance their roles in research, little information exists on how to prepare CHWs involved in community-academic initiatives (CAIs). Therefore, the New York University Prevention Research Center piloted a CAI-CHW training program. We applied a core competency framework to an existing CHW curriculum and bolstered the curriculum to include research-specific sessions. We employed diverse training methods, guided by adult learning principles and popular education philosophy. Evaluation instruments assessed changes related to confidence, intention to use learned skills, usefulness of sessions, and satisfaction with the training. Results demonstrated that a core competency-based training can successfully affect CHWs' perceived confidence and intentions to apply learned content, and can provide a larger social justice context of their role and work. This program demonstrates that a core competency-based framework coupled with CAI-research-specific skill sessions (1) provides skills that CAI-CHWs intend to use, (2) builds confidence, and (3) provides participants with a more contextualized view of client needs and CHW roles.

Report from the International Conference on Dublin Core and Metadata Applications, 2001.

ERIC Educational Resources Information Center

Sugimoto, Shigeo; Adachi, Jun; Baker, Thomas; Weibel, Stuart

This paper describes the International Conference on Dublin Core and Metadata Applications 2001 (DC-2001), the ninth major workshop of the Dublin Core Metadata Initiative (DCMI), which was held in Tokyo in October 2001. DC-2001 was a week-long event that included both a workshop and a conference. In the tradition of previous events, the workshop…

The CORE Community: Career and Technical Education Teachers' Perceptions of the Common Core State Standards after a Professional Development Training

ERIC Educational Resources Information Center

Stair, Kristin; Hock, Gaea; Warner, Wendy; Levy, Natalie; Conrad, Michelle

2017-01-01

Since the 1983 U.S Department of Education's report, "A Nation at Risk," various educational initiatives have been developed to support an increase in state standards and greater educational accountability (Liebtag, 2013). Despite opportunities to link Common Core State Standards (CCSS) and instructional curriculum, CTE teachers often…

77 FR 72827 - Corrosion-Resistant Carbon Steel Flat Products From Germany and the Republic of Korea: Final...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-06

... carbon steel flat products (``CORE'') from Germany and the Republic of Korea (``Korea'').\\1\\ We received... On January 3, 2012, the Department initiated the third sunset review of the AD orders on CORE from... respondent in either of the sunset reviews of the AD orders on CORE from Germany and Korea. As a result...

The punctilious RNA polymerase II core promoter

PubMed Central

Vo ngoc, Long; Wang, Yuan-Liang; Kassavetis, George A.; Kadonaga, James T.

2017-01-01

The signals that direct the initiation of transcription ultimately converge at the core promoter, which is the gateway to transcription. Here we provide an overview of the RNA polymerase II core promoter in bilateria (bilaterally symmetric animals). The core promoter is diverse in terms of its composition and function yet is also punctilious, as it acts with strict rules and precision. We additionally describe an expanded view of the core promoter that comprises the classical DNA sequence motifs, sequence-specific DNA-binding transcription factors, chromatin signals, and DNA structure. This model may eventually lead to a more unified conceptual understanding of the core promoter. PMID:28808065

Development of a core outcome set for clinical trials in facial aging: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey.

PubMed

Schlessinger, Daniel I; Iyengar, Sanjana; Yanes, Arianna F; Henley, Jill K; Ashchyan, Hovik J; Kurta, Anastasia O; Patel, Payal M; Sheikh, Umar A; Franklin, Matthew J; Hanna, Courtney C; Chen, Brian R; Chiren, Sarah G; Schmitt, Jochen; Deckert, Stefanie; Furlan, Karina C; Poon, Emily; Maher, Ian A; Cartee, Todd V; Sobanko, Joseph F; Alam, Murad

2017-08-01

Facial aging is a concern for many patients. Wrinkles, loss of volume, and discoloration are common physical manifestations of aging skin. Genetic heritage, prior ultraviolet light exposure, and Fitzpatrick skin type may be associated with the rate and type of facial aging. Although many clinical trials assess the correlates of skin aging, there is heterogeneity in the outcomes assessed, which limits the quality of evaluation and comparison of treatment modalities. To address the inconsistency in outcomes, in this project we will develop a core set of outcomes that are to be evaluated in all clinical trials relevant to facial aging. A long list of measureable outcomes will be created from four sources: (1) systematic medical literature review, (2) patient interviews, (3) other published sources, and (4) stakeholder involvement. Two rounds of Delphi processes with homogeneous groups of physicians and patients will be performed to prioritize and condense the list. At a consensus meeting attended by physicians, patients, and stakeholders, outcomes will be further condensed on the basis of participant scores. By the end of the meeting, members will vote and decide on a final recommended set of core outcomes. Subsequent to this, specific measures will be selected or created to assess these outcomes. The aim of this study is to develop a core outcome set and relevant measures for clinical trials relevant to facial aging. We hope to improve the reliability and consistency of outcome reporting of skin aging, thereby enabling improved evaluation of treatment efficacy and patient satisfaction. Core Outcome Measures in Effectiveness Trials (COMET) Initiative, accessible at http://www.comet-initiative.org/studies/details/737 . Core Outcomes Set Initiative, (CSG-COUSIN) accessible at https://www.uniklinikum-dresden.de/de/das-klinikum/universitaetscentren/zegv/cousin/meet-the-teams/project-groups/core-outcome-set-for-the-appearance-of-facial-aging . Protocol version date is 28 July 2016.

Lower Anogenital Tract Disease Therapy Outcomes, COMET, and CROWN: Call for Research Submissions.

PubMed

Andrews, Jeffrey

2015-10-01

There is a problem of inconsistent and inappropriate outcome selection for research studies. We can improve the relevance of research results for women and for their physicians and clinicians by encouraging researchers to critically evaluate outcome measures, and use valid, appropriate, standardized measures. To this purpose, and to facilitate synthesis of the evidence, outcomes reported by clinical studies should be standardized for different disease conditions through the development of core outcome sets (COS). There is an international effort for reaching consensus on outcome measures and establishing COS that represent agreed-upon standardized collections of outcome measures that will be reported in all studies within a clinical area. Across clinical specialties, the Core Outcome Measures in Effectiveness Trials (COMET) initiative launched in 2010. In 2014, the editors of women's health journals answered the challenge of COMET and formed the Core Outcomes in Women's Health initiative. The Journal of Lower Genital Tract Diseases is a participating member of the Core Outcomes in Women's Health consortium. There is broad inconsistency in outcome measures and reporting in the field of lower anogenital tract diseases. No core outcome sets currently exist. Suggested target conditions in anogenital disease are vulvar dermatoses, cervical intraepithelial neoplasia, and vulvodynia. Investigators are encouraged to conduct secondary systematic research to determine previously reported primary outcome measures and suggest domains for COS. Core Outcomes in Women's health initiative and COMET encourage the formation of consensus panels of stakeholders (researchers, health care providers, patients, and others) to recommend outcome domains and COS and then publish their report.

CONSIDER - Core Outcome Set in IAD Research: study protocol for establishing a core set of outcomes and measurements in incontinence-associated dermatitis research.

PubMed

Van den Bussche, Karen; De Meyer, Dorien; Van Damme, Nele; Kottner, Jan; Beeckman, Dimitri

2017-10-01

This study protocol describes the methodology for the development of a core set of outcomes and a core set of measurements for incontinence-associated dermatitis. Incontinence is a widespread disorder with an important impact on quality of life. One of the most common complications is incontinence-associated dermatitis, resulting from chemical and physical irritation of the skin barrier, triggering inflammation and skin damage. Managing incontinence-associated dermatitis is an important challenge for nurses. Several interventions have been assessed in clinical trials, but heterogeneity in study outcomes complicates the comparability and standardization. To overcome this challenge, the development of a core outcome set, a minimum set of outcomes and measurements to be assessed in clinical research, is needed. A project team, International Steering Committee and panelists will be involved to guide the development of the core outcome set. The framework of the Harmonizing Outcomes Measures for Eczema roadmap endorsed by Cochrane Skin Group Core Outcomes Set Initiative, is used to inform the project design. A systematic literature review, interviews to integrate the patients' perspective and a consensus study with healthcare researchers and providers using the Delphi procedure will be performed. The project was approved by the Ethics review Committee (April 2016). This is the first project that will identify a core outcome set of outcomes and measurements for incontinence-associated dermatitis research. A core outcome set will reduce possible reporting bias, allow results comparisons and statistical pooling across trials and strengthen evidence-based practice and decision-making. This project has been registered in the Core Outcome Measures in Effectiveness Trials (COMET) database and is part of the Cochrane Skin Group Core Outcomes Set Initiative (CSG-COUSIN). © 2016 John Wiley & Sons Ltd.

PhysDoc: A Distributed Network of Physics Institutions: Collecting, Indexing, and Searching High Quality Documents by Using Harvest; The Dublin Core Metadata Initiative: Mission, Current Activities, and Future Directions; Information Services for Higher Education: A New Competitive Space; Intellectual Property Conservancies.

ERIC Educational Resources Information Center

Severiens, Thomas; Hohlfeld, Michael; Zimmermann, Kerstin; Hilf, Eberhard R.; von Ossietzky, Carl; Weibel, Stuart L.; Koch, Traugott; Hughes, Carol Ann; Bearman, David

2000-01-01

Includes four articles that discuss a variety to topics, including a distributed network of physics institutions documents called PhysDocs which harvests information from the local Web-servers of professional physics institutions; the Dublin Core metadata initiative; information services for higher education in a competitive environment; and…

Trends in the Evolution of the Public Web, 1998-2002; The Fedora Project: An Open-source Digital Object Repository Management System; State of the Dublin Core Metadata Initiative, April 2003; Preservation Metadata; How Many People Search the ERIC Database Each Day?

ERIC Educational Resources Information Center

O'Neill, Edward T.; Lavoie, Brian F.; Bennett, Rick; Staples, Thornton; Wayland, Ross; Payette, Sandra; Dekkers, Makx; Weibel, Stuart; Searle, Sam; Thompson, Dave; Rudner, Lawrence M.

2003-01-01

Includes five articles that examine key trends in the development of the public Web: size and growth, internationalization, and metadata usage; Flexible Extensible Digital Object and Repository Architecture (Fedora) for use in digital libraries; developments in the Dublin Core Metadata Initiative (DCMI); the National Library of New Zealand Te Puna…

Utilization of a duckweed bioassay to evaluate leaching of heavy metals in smelter contaminated soils

DOE Office of Scientific and Technical Information (OSTI.GOV)

Youngman, A.L.; Lydy, M.J.; Williams, T.L.

1998-12-31

The purpose of this study was to determine whether a duckweed bioassay could be used to evaluate the downward migration of heavy metals in smelter soils. The duckweed bioassay was initially used to evaluate elutriates prepared from samples of smelter soils. These initial tests verified that the elutriates would elicit toxic responses. Elutriate testing was followed with an evaluation of leachate from untreated soil cores or soil cores that had been amended with organic matter either unplanted or planted to a grass-forb seed mixture. There was an inverse linear relationship between heavy-metal concentrations in leachate and NOEC and IC{sub 50}more » values expressed as percentages among all soil cores. Based on these preliminary duckweed bioassays, there were no differences between soil types or organic amended or non-amended soil, but leachate from vegetated soil cores were less toxic than were leachates from non-vegetated soil cores. Overall, the duckweed bioassays were useful in detecting heavy metal availability in elutriate and leachate samples from smelter soils.« less

The Alzheimer's Disease Neuroimaging Initiative 2 PET Core: 2015.

PubMed

Jagust, William J; Landau, Susan M; Koeppe, Robert A; Reiman, Eric M; Chen, Kewei; Mathis, Chester A; Price, Julie C; Foster, Norman L; Wang, Angela Y

2015-07-01

This article reviews the work done in the Alzheimer's Disease Neuroimaging Initiative positron emission tomography (ADNI PET) core over the past 5 years, largely concerning techniques, methods, and results related to amyloid imaging in ADNI. The PET Core has used [(18)F]florbetapir routinely on ADNI participants, with over 1600 scans available for download. Four different laboratories are involved in data analysis, and have examined factors such as longitudinal florbetapir analysis, use of [(18)F]fluorodeoxyglucose (FDG)-PET in clinical trials, and relationships between different biomarkers and cognition. Converging evidence from the PET Core has indicated that cross-sectional and longitudinal florbetapir analyses require different reference regions. Studies have also examined the relationship between florbetapir data obtained immediately after injection, which reflects perfusion, and FDG-PET results. Finally, standardization has included the translation of florbetapir PET data to a centiloid scale. The PET Core has demonstrated a variety of methods for the standardization of biomarkers such as florbetapir PET in a multicenter setting. Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

One Health Core Competency Domains.

PubMed

Frankson, Rebekah; Hueston, William; Christian, Kira; Olson, Debra; Lee, Mary; Valeri, Linda; Hyatt, Raymond; Annelli, Joseph; Rubin, Carol

2016-01-01

The emergence of complex global challenges at the convergence of human, animal, and environmental health has catalyzed a movement supporting "One Health" approaches. Despite recognition of the importance of One Health approaches to address these complex challenges, little effort has been directed at identifying the seminal knowledge, skills, and attitudes necessary for individuals to successfully contribute to One Health efforts. Between 2008 and 2011, three groups independently embarked on separate initiatives to identify core competencies for professionals involved with One Health approaches. Core competencies were considered critically important for guiding curriculum development and continuing professional education, as they describe the knowledge, skills, and attitudes required to be effective. A workshop was convened in 2012 to synthesize the various strands of work on One Health competencies. Despite having different mandates, participants, and approaches, all of these initiatives identified similar core competency domains: management; communication and informatics; values and ethics; leadership; teams and collaboration; roles and responsibilities; and systems thinking. These core competency domains have been used to develop new continuing professional education programs for One Health professionals and help university curricula prepare new graduates to be able to contribute more effectively to One Health approaches.

Response Surface Methodology for Design of Porous Hollow Sphere Thermal Insulator

NASA Astrophysics Data System (ADS)

Shohani, Nazanin; Pourmahdian, Saeed; Shirkavand Hadavand, Behzad

2017-11-01

In this study, response surface method is used for synthesizing polystyrene (PS) as sacrificial templates and optimizing the particle size. Three factors of initiator, stabilizer concentration and also stirring rate were selected as variable factors. Then, three different concentration of tetraethyl orthosilicate (TEOS) added to reaction media and core-shell structure with PS core and silica shell was developed. Finally, core-shell structure was changed to hollow silica sphere for using as thermal insulator. We observed that increased initiator concentration caused to larger PS particles, increase the stirring rate caused the smaller PS and also with increased the stabilizer concentration obtained that particle size decrease then after 2.5% began to increase. Also the optimum amount of TEOS was found.

Initial Testing of the Stainless Steel NaK-Cooled Circuit (SNaKC)

NASA Technical Reports Server (NTRS)

Garber, Anne; Godfroy, Thomas

2007-01-01

An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, is currently undergoing testing in the Early Flight Fission Test Facility (EFF-TF). Sodium potassium (NaK) was selected as the primary coolant. Basic circuit components include: simulated reactor core, NaK to gas heat exchanger, electromagnetic liquid metal pump, liquid metal flowmeter, load/drain reservoir, expansion reservoir, test section, and instrumentation. Operation of the circuit is based around the 37-pin partial-array core (pin and flow path dimensions are the same as those in a full core), designed to operate at 33 kWt. This presentation addresses the construction, fill and initial testing of the Stainless Steel NaK-Cooled Circuit (SNaKC).

77 FR 64148 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Regulatory...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-18

... Regulatory Guides (RG) RG 1.79, ````Preoperational Testing of Emergency Core Cooling Systems for Pressurized Water Reactors,'' Revision 2 and RG 1.79.1, ``Initial Test Program of Emergency Core Cooling Systems for...

Stars By Which to Navigate? Scanning National and International Education Standards in 2009. An Interim Report on Common Core, NAEP, TIMSS and PISA

ERIC Educational Resources Information Center

Carmichael, Sheila Byrd; Wilson, W. Stephen; Finn, Chester E., Jr.; Winkler, Amber M.; Palmieri, Stafford

2009-01-01

Subject-matter experts reviewed the content, rigor, and clarity of the first public drafts of the "Common Core" standards released in September 2009 by the Common Core State Standards Initiative (CCSSI) of the National Governors Association and Council of Chief State School Officers. Using the same criteria, the same experts also…

A core outcome set for clinical trials on non-specific low back pain: study protocol for the development of a core domain set.

PubMed

Chiarotto, Alessandro; Terwee, Caroline B; Deyo, Richard A; Boers, Maarten; Lin, Chung-Wei Christine; Buchbinder, Rachelle; Corbin, Terry P; Costa, Leonardo O P; Foster, Nadine E; Grotle, Margreth; Koes, Bart W; Kovacs, Francisco M; Maher, Chris G; Pearson, Adam M; Peul, Wilco C; Schoene, Mark L; Turk, Dennis C; van Tulder, Maurits W; Ostelo, Raymond W

2014-12-26

Low back pain (LBP) is one of the most disabling and costly disorders affecting modern society, and approximately 90% of patients are labelled as having non-specific LBP (NSLBP). Several interventions for patients with NSLBP have been assessed in clinical trials, but heterogeneous reporting of outcomes in these trials has hindered comparison of results and performance of meta-analyses. Moreover, there is a risk of selective outcome reporting bias. To address these issues, the development of a core outcome set (COS) that should be measured in all clinical trials for a specific health condition has been recommended. A standardized set of outcomes for LBP was proposed in 1998, however, with evolution in COS development methodology, new instruments, interventions, and understanding of measurement properties, it is appropriate to update that proposal. This protocol describes the methods used in the initial step in developing a COS for NSLBP, namely, establishing a core domain set that should be measured in all clinical trials. An International Steering Committee including researchers, clinicians, and patient representatives from four continents was formed to guide the development of this COS. The approach of initiatives like Core Outcome Measures in Effectiveness Trials (COMET) and Outcome Measures in Rheumatology (OMERACT) was followed. Participants were invited to participate in a Delphi study aimed at generating a consensus-based core domain set for NSLBP. A list of potential core domains was drafted and presented to the Delphi participants who were asked to judge which domains were core. Participant suggestions about overlap, aggregation, or addition of potential core domains were addressed during the study. The patients' responses were isolated to assess whether there was substantial disagreement with the rest of the Delphi panel. A priori thresholds for consensus were established before each Delphi round. All participants' responses were analysed from a quantitative and qualitative perspective to ascertain that no substantial discrepancies between the two approaches emerged. We present the initial step in developing a COS for NSLBP. The next step will be to determine which measurement instruments adequately cover the domains.

Pre-main sequence sun: a dynamic approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Newman, M.J.; Winkler, K.H.A.

1979-01-01

The classical pre-main sequence evolutionary behavior found by Hayashi and his coworkers for the Sun depends crucially on the choice of initial conditions. The Hayashi picture results from beginning the calculation with an already centrally condensed, highly Jeans unstable object not terribly far removed from the stellar state initially. The present calculation follows the work of Larson in investigating the hydrodynamic collapse and self-gravitational accretion of an initially uniform, just Jeans unstable interstellar gas-dust cloud. The resulting picture for the early history of the Sun is quite different from that found by Hayashi. A rather small (R approx. = 2more » R/sub sun/), low-luminosity (L greater than or equal to L/sub sun/) protostellar core develops. A fully convective stellar core, characteristic of Hayashi's work, is not found during the accretion process, and can only develop, if at all, in the subsequent pre-main sequence Kelvin-Helmholtz contraction of the core. 3 figures, 1 table.« less

Self-Healing Nanotextured Vascular-like Materials: Mode I Crack Propagation.

PubMed

Lee, Min Wook; Sett, Soumyadip; An, Seongpil; Yoon, Sam S; Yarin, Alexander L

2017-08-16

Here, we investigate crack propagation initiated from an initial notch in a self-healing material. The crack propagation in the core-shell nanofiber mats formed by coelectrospinning and the composites reinforced by them is in focus. All samples are observed from the crack initiation until complete failure. Due to the short-time experiments done on purpose, the resin and cure released from the cores of the core-shell nanofibers could not achieve a complete curing and stop crack growth, especially given the fact that no heating was used. The aim is to elucidate their effect on the rate of crack propagation. The crack propagation speed in polyacrylonitrile (PAN)-resin-cure nanofiber mats (with PAN being the polymer in the shell) was remarkably lower than that in the corresponding monolithic PAN nanofiber mat, down to 10%. The nanofiber mats were also encased in polydimethylsiloxane (PDMS) matrix to form composites. The crack shape and propagation in the composite samples were studied experimentally and analyzed theoretically, and the theoretical results revealed agreement with the experimental data.

Core Formation on Asteroid 4 Vesta: Iron Rain in a Silicate Magma Ocean

NASA Astrophysics Data System (ADS)

Kiefer, W. S.; Mittlefehldt, D. W.

2017-07-01

Initially small liquid metal drops must grow to about 10 cm in size before sinking through the convecting silicate magma ocean to form a core. The required magma temperature is consistent with moderately siderophile element abundances in eucrites.

Who Is Your Coach?

ERIC Educational Resources Information Center

Bowman, Richard F.

2017-01-01

Initial teacher licensing is intended to provide public assurance of core competence in classroom settings. Core competence's implicit vulnerability is mediocrity. In daily practice, many educators appear satisfied in reaching a merely acceptable level of performance, thus minimizing the period of effortful skill acquisition required to attain…

Utility and applicability of the "Childhood Obesity Risk Evaluation" (CORE)-index in predicting obesity in childhood and adolescence in Greece from early life: the "National Action Plan for Public Health".

PubMed

Manios, Yannis; Vlachopapadopoulou, Elpis; Moschonis, George; Karachaliou, Feneli; Psaltopoulou, Theodora; Koutsouki, Dimitra; Bogdanis, Gregory; Carayanni, Vilelmine; Hatzakis, Angelos; Michalacos, Stefanos

2016-12-01

Early identification of infants being at high risk to become obese at their later childhood or adolescence can be of vital importance in any obesity prevention initiative. The aim of the present study was to examine the utility and applicability of the "Childhood Obesity Risk Evaluation (CORE)" index as a screening tool for the early prediction of obesity in childhood and adolescence. Anthropometric, socio-demographic data were collected cross-sectionally and retrospectively from a representative sample of 5946 children, and adolescents and were combined for calculating the CORE-index score. Logistic regression analyses were performed to examine the associations of the CORE-index score with obesity by gender and age group, and cut-off point analysis was also applied to identify the optimal value of the CORE-index score that differentiates obese from non-obese children. Mean CORE-index score in the total sample was 3.06 (sd 1.92) units (range 0-11 units). Each unit increase in the CORE-index score was found to be associated with a 30 % (95 % C.I. 1.24-1.36) increased likelihood for obesity in childhood or adolescence, while the optimal cut-off value of the CORE-index score that predicted obesity with the highest possible sensitivity and specificity was found to be 3.5. The present study supports the utility and applicability of the CORE-index as a screening tool for the early identification of infants that are potentially at a higher risk for becoming obese at their childhood and adolescence. This tool could be routinely used by health professionals to identify infants at high risk and provide appropriate counselling to their parents and caregivers so as to maximize the effectiveness of early obesity prevention initiatives. What is known? • Childhood obesity has reached epidemic proportions worldwide. • Certain perinatal and socio-demographic indices that were previously identified as correlates of childhood obesity in children were combined to develop the CORE-index, a screening tool that estimates obesity risk in 9-13 year-old children. What is new? • The utility and applicability of the CORE-index as screening tool can be extended to the age range of 6-15 years. • The CORE-index is a cost-effective screening tool that can assist health professionals in initiating obesity preventive measures from early life.

A New Mass Criterium for Electron Capture Supernovae

NASA Astrophysics Data System (ADS)

Poelarends, Arend

2016-06-01

Electron capture supernovae (ECSN) are thought to populate the mass range between massive white dwarf progenitors and core collapse supernovae. It is generally believed that the initial stellar mass range for ECSN from single stars is about 0.5-1.0 M⊙ wide and centered around a value of 8.5 or 9 M⊙, depending on the specifics of the physics of convection and mass loss one applies. Since mass loss in a binary system is able to delay or cancel the second dredge-up, it is also believed that the initial mass range for ECSN in binary systems is wider than in single stars, but an initial mass range has not been defined yet.The last phase of stars in this particular mass range, however, is challenging to compute, either due to recurring Helium shell flashes, or due to convectively bound flames in the degenerate interior of the star. It would be helpful, nevertheless, to know before we enter these computationally intensive phases whether a star will explode as an ECSN or not. The mass of the helium core after helium core burning is one such criterium (Nomoto, 1984), which predicts that ECSN will occur if the helium core mass is between 2.0 M⊙ and 2.5 M⊙. However, since helium cores can be subject to erosion due to mass loss — even during helium core burning, this criterium will not yield accurate predictions for stars in binary systems.We present a dense grid of stellar evolution models that allow us to put constraints on the final fate of their cores, based on a combination of Carbon/Oxygen core mass, the mass of the surrounding Helium layer and C/O abundance. We find that CO cores with masses between 1.365 and 1.420 M⊙ at the end of Carbon burning will result in ECSN, with some minor adjustments of these ranges due to the mass of the Helium layer and the C/O ratio. While detailed models of stars within the ECSN mass range remain necessary to understand the details of pre-ECSN evolution, our research refines the Helium core criterion and provides a useful way to determine the final fate of stars in this complicated mass range early on.

Synthesis of highly monodisperse particles composed of a magnetic core and fluorescent shell.

PubMed

Nagao, Daisuke; Yokoyama, Mikio; Yamauchi, Noriko; Matsumoto, Hideki; Kobayashi, Yoshio; Konno, Mikio

2008-09-02

Highly monodisperse particles composed of a magnetic silica core and fluorescent polymer shell were synthesized with a combined technique of heterocoagulation and soap-free emulsion polymerization. Prior to heterocoagulation, monodisperse, submicrometer-sized silica particles were prepared with the Stober method, and magnetic nanoparticles were prepared with a modified Massart method in which a cationic silane coupling agent of N-trimethoxysilylpropyl- N, N, N-trimethylammonium chloride was added just after coprecipitation of Fe (2+) and Fe (3+). The silica particles with negative surface potential were heterocoagulated with the magnetic nanoparticles with positive surface potential. The magnetic silica particles obtained with the heterocoagulation were treated with sodium silicate to modify their surfaces with silica. In the formation of a fluorescent polymer shell onto the silica-coated magnetic silica cores, an amphoteric initiator of 2,2'-azobis[ N-(2-carboxyethyl)-2-2-methylpropionamidine] (VA-057) was used to control the colloidal stability of the magnetic cores during the polymer coating. The polymerization of St in the presence of a hydrophobic fluorophore of pyrene could coat the cores with fluorescent polymer shells, resulting in monodisperse particles with a magnetic silica core and fluorescent polymer shell. Measurements of zeta potential for the composite particles in different pH values indicated that the composite particles had an amphoteric property originating from VA-057 initiator.

3D numerical calculations and synthetic observations of magnetized massive dense core collapse and fragmentation.

NASA Astrophysics Data System (ADS)

Commerçon, B.; Hennebelle, P.; Levrier, F.; Launhardt, R.; Henning, Th.

2012-03-01

I will present radiation-magneto-hydrodynamics calculations of low-mass and massive dense core collapse, focusing on the first collapse and the first hydrostatic core (first Larson core) formation. The influence of magnetic field and initial mass on the fragmentation properties will be investigated. In the first part reporting low mass dense core collapse calculations, synthetic observations of spectral energy distributions will be derived, as well as classical observational quantities such as bolometric temperature and luminosity. I will show how the dust continuum can help to target first hydrostatic cores and to state about the nature of VeLLOs. Last, I will present synthetic ALMA observation predictions of first hydrostatic cores which may give an answer, if not definitive, to the fragmentation issue at the early Class 0 stage. In the second part, I will report the results of radiation-magneto-hydrodynamics calculations in the context of high mass star formation, using for the first time a self-consistent model for photon emission (i.e. via thermal emission and in radiative shocks) and with the high resolution necessary to resolve properly magnetic braking effects and radiative shocks on scales <100 AU (Commercon, Hennebelle & Henning ApJL 2011). In this study, we investigate the combined effects of magnetic field, turbulence, and radiative transfer on the early phases of the collapse and the fragmentation of massive dense cores (M=100 M_⊙). We identify a new mechanism that inhibits initial fragmentation of massive dense cores, where magnetic field and radiative transfer interplay. We show that this interplay becomes stronger as the magnetic field strength increases. We speculate that highly magnetized massive dense cores are good candidates for isolated massive star formation, while moderately magnetized massive dense cores are more appropriate to form OB associations or small star clusters. Finally we will also present synthetic observations of these collapsing massive dense cores.

Bringing Promise to Washington, DC. The DC Promise Neighborhood Initiative. Program on Neighborhoods and Youth Development

ERIC Educational Resources Information Center

Comey, Jennifer; Scott, Molly M.; Popkin, Susan J.; Falkenburger, Elsa

2012-01-01

The U.S. Department of Education's Promise Neighborhood Initiative (DCPNI) is one of the Obama administration's major antipoverty initiatives and a core strategy of the White House's Neighborhood Revitalization Initiative. It is intended to improve educational outcomes by creating a continuum of school readiness, academic services, and family and…

A qualitative study of the core functions of Smart Traffic Centers at the Virginia Department of Transportation.

DOT National Transportation Integrated Search

2006-01-01

The Virginia Department of Transportation's (VDOT) Smart Traffic Centers (STC) were established to address the growing problem of increased congestion caused by traffic demand exceeding roadway capacity. Initially, the core function of the STC was si...

Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2.

PubMed

Jack, Clifford R; Barnes, Josephine; Bernstein, Matt A; Borowski, Bret J; Brewer, James; Clegg, Shona; Dale, Anders M; Carmichael, Owen; Ching, Christopher; DeCarli, Charles; Desikan, Rahul S; Fennema-Notestine, Christine; Fjell, Anders M; Fletcher, Evan; Fox, Nick C; Gunter, Jeff; Gutman, Boris A; Holland, Dominic; Hua, Xue; Insel, Philip; Kantarci, Kejal; Killiany, Ron J; Krueger, Gunnar; Leung, Kelvin K; Mackin, Scott; Maillard, Pauline; Malone, Ian B; Mattsson, Niklas; McEvoy, Linda; Modat, Marc; Mueller, Susanne; Nosheny, Rachel; Ourselin, Sebastien; Schuff, Norbert; Senjem, Matthew L; Simonson, Alix; Thompson, Paul M; Rettmann, Dan; Vemuri, Prashanthi; Walhovd, Kristine; Zhao, Yansong; Zuk, Samantha; Weiner, Michael

2015-07-01

Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Development of a three-dimensional transient code for reactivity-initiated events of BWRs (boiling water reactors) - Models and code verifications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uematsu, Hitoshi; Yamamoto, Toru; Izutsu, Sadayuki

1990-06-01

A reactivity-initiated event is a design-basis accident for the safety analysis of boiling water reactors. It is defined as a rapid transient of reactor power caused by a reactivity insertion of over $1.0 due to a postulated drop or abnormal withdrawal of the control rod from the core. Strong space-dependent feedback effects are associated with the local power increase due to control rod movement. A realistic treatment of the core status in a transient by a code with a detailed core model is recommended in evaluating this event. A three-dimensional transient code, ARIES, has been developed to meet this need.more » The code simulates the event with three-dimensional neutronics, coupled with multichannel thermal hydraulics, based on a nonequilibrium separated flow model. The experimental data obtained in reactivity accident tests performed with the SPERT III-E core are used to verify the entire code, including thermal-hydraulic models.« less

Effect of the Grain Size of the Initial Structure of 1565chM Alloy on the Structure and Properties of the Joints Fabricated by Friction Stir Welding

NASA Astrophysics Data System (ADS)

Ovchinnikov, V. V.; Drits, A. M.; Gureeva, M. A.; Malov, D. V.

2017-12-01

The effect of the initial grain size in the structure of the aluminum 1565chM alloy on the mechanical properties of the welded joints formed by friction stir welding and on the grain size in the weld core is studied. It is shown that the design of tool and, especially, the parameters of a screw groove exert a great effect on the grain size in the weld core.

Digital Preservation and Deep Infrastructure; Dublin Core Metadata Initiative Progress Report and Workplan for 2002; Video Gaming, Education and Digital Learning Technologies: Relevance and Opportunities; Digital Collections of Real World Objects; The MusArt Music-Retrieval System: An Overview; eML: Taking Mississippi Libraries into the 21st Century.

ERIC Educational Resources Information Center

Granger, Stewart; Dekkers, Makx; Weibel, Stuart L.; Kirriemuir, John; Lensch, Hendrik P. A.; Goesele, Michael; Seidel, Hans-Peter; Birmingham, William; Pardo, Bryan; Meek, Colin; Shifrin, Jonah; Goodvin, Renee; Lippy, Brooke

2002-01-01

One opinion piece and five articles in this issue discuss: digital preservation infrastructure; accomplishments and changes in the Dublin Core Metadata Initiative in 2001 and plans for 2002; video gaming and how it relates to digital libraries and learning technologies; overview of a music retrieval system; and the online version of the…

U.S. National Institutes of Health core consolidation-investing in greater efficiency.

PubMed

Chang, Michael C; Birken, Steven; Grieder, Franziska; Anderson, James

2015-04-01

The U.S. National Institutes of Health (NIH) invests substantial resources in core research facilities (cores) that support research by providing advanced technologies and scientific and technical expertise as a shared resource. In 2010, the NIH issued an initiative to consolidate multiple core facilities into a single, more efficient core. Twenty-six institutions were awarded supplements to consolidate a number of similar core facilities. Although this approach may not work for all core settings, this effort resulted in consolidated cores that were more efficient and of greater benefit to investigators. The improvements in core operations resulted in both increased services and more core users through installation of advanced instrumentation, access to higher levels of management expertise; integration of information management and data systems; and consolidation of billing; purchasing, scheduling, and tracking services. Cost recovery to support core operations also benefitted from the consolidation effort, in some cases severalfold. In conclusion, this program of core consolidation resulted in improvements in the effective operation of core facilities, benefiting both investigators and their supporting institutions.

Status Report on the Illinois Articulation Initiative.

ERIC Educational Resources Information Center

Illinois Community Coll. Board, Springfield.

The Illinois Articulation Initiative is a comprehensive statewide effort among colleges and universities to enhance the transfer process for students among all sectors of higher education in Illinois. One of the main features of the initiative is the general education core curriculum and a list of statewide articulated general education courses…

Access to the Common Core for All

ERIC Educational Resources Information Center

McLaughlin, Margaret J.

2012-01-01

Too often under the various state-developed standards and assessments, accommodations for students with disabilities--a heterogeneous group with varied characteristics and needs--have not been adequately addressed or have been ignored. The Common Core State Standards (CCSS) initiative provides an historic opportunity to improve access to rigorous…

A 150 kyr-long hydroclimate record from Southern California using Searles Lake sediments: initial findings

NASA Astrophysics Data System (ADS)

Stroup, J. S.; Olson, K. J.; McGee, D.; Lowenstein, T. K.; Smoot, J. P.; Janick, J. J.; Lund, S.; Peaple, M.; Chen, C. Y.; Feakins, S. J.; Litwin, R.

2017-12-01

Over decadal to millennial scales, the southwestern U.S has experienced large shifts in hydroclimate ranging from pluvial conditions to extreme droughts. Direct observations, modeling and proxy data suggest precipitation amount and distribution are controlled by multiple factors including the position of the Hadley Cell, strength of the Aleutian Low and North Pacific High, ENSO and the path of winter storm tracks. Sediment records from closed basin lakes provide a means for assessing how hydrologic conditions have responded to past climate changes; however, long (>50 ka) paleoclimate records from lakes are rare and high-resolution age models are challenging to obtain. Searles Lake, in southeastern California, contains a sedimentary record that spans from the Holocene to the Pliocene at high resolution. Previous drill core studies from the basin used stratigraphy and sediment mineralogy to interpret paleoenvironmental changes and have demonstrated that the lake's sediments are able to be precisely dated. These results provide a strong foundation for new high-resolution investigations of the lake sediments. In January 2017, our group collected a new 80 m-long core with the aim of reconstructing hydrologic changes over the last 150 ka at millennial or better resolution. The core was split at the National Lacustrine Core Facility (LacCore) in June. The core contains alternating evaporite layers and finely laminated muds which likely indicate times of dryer and wetter conditions. Despite the challenge of alternating lithologies, core recovery and quality are extremely high. Here, we will present our initial chronological and stratigraphic findings. The core record will be dated using a combination of U/Th, 14C and magnetostratigraphy. We will compare our initial stratigraphic description to the existing Searles Lake literature as well as other records from the region, such as data from Devils Hole. These results provide the framework upon which we will develop detailed stratigraphic and crystallographic interpretations as well as a host of proxy records including leaf waxes, pollen and stable isotopes to advance our understanding of paleoenvironment and paleoclimate.

One Health Core Competency Domains

PubMed Central

Frankson, Rebekah; Hueston, William; Christian, Kira; Olson, Debra; Lee, Mary; Valeri, Linda; Hyatt, Raymond; Annelli, Joseph; Rubin, Carol

2016-01-01

The emergence of complex global challenges at the convergence of human, animal, and environmental health has catalyzed a movement supporting “One Health” approaches. Despite recognition of the importance of One Health approaches to address these complex challenges, little effort has been directed at identifying the seminal knowledge, skills, and attitudes necessary for individuals to successfully contribute to One Health efforts. Between 2008 and 2011, three groups independently embarked on separate initiatives to identify core competencies for professionals involved with One Health approaches. Core competencies were considered critically important for guiding curriculum development and continuing professional education, as they describe the knowledge, skills, and attitudes required to be effective. A workshop was convened in 2012 to synthesize the various strands of work on One Health competencies. Despite having different mandates, participants, and approaches, all of these initiatives identified similar core competency domains: management; communication and informatics; values and ethics; leadership; teams and collaboration; roles and responsibilities; and systems thinking. These core competency domains have been used to develop new continuing professional education programs for One Health professionals and help university curricula prepare new graduates to be able to contribute more effectively to One Health approaches. PMID:27679794

Methods of developing core collections based on the predicted genotypic value of rice ( Oryza sativa L.).

PubMed

Li, C T; Shi, C H; Wu, J G; Xu, H M; Zhang, H Z; Ren, Y L

2004-04-01

The selection of an appropriate sampling strategy and a clustering method is important in the construction of core collections based on predicted genotypic values in order to retain the greatest degree of genetic diversity of the initial collection. In this study, methods of developing rice core collections were evaluated based on the predicted genotypic values for 992 rice varieties with 13 quantitative traits. The genotypic values of the traits were predicted by the adjusted unbiased prediction (AUP) method. Based on the predicted genotypic values, Mahalanobis distances were calculated and employed to measure the genetic similarities among the rice varieties. Six hierarchical clustering methods, including the single linkage, median linkage, centroid, unweighted pair-group average, weighted pair-group average and flexible-beta methods, were combined with random, preferred and deviation sampling to develop 18 core collections of rice germplasm. The results show that the deviation sampling strategy in combination with the unweighted pair-group average method of hierarchical clustering retains the greatest degree of genetic diversities of the initial collection. The core collections sampled using predicted genotypic values had more genetic diversity than those based on phenotypic values.

Descriptions and preliminary interpretations of cores recovered from the Manson Impact Structure (Iowa)

NASA Technical Reports Server (NTRS)

Anderson, R. R.; Witzke, B. J.; Hartung, J. B.; Shoemaker, E. M.; Roddy, D. J.

1993-01-01

A core drilling program initiated by the Iowa Geological Survey Bureau and U.S. Geological Survey in 1991 and 1992 collected 12 cores totalling over 1200 m from the Manson Impact Structure, a probable K-T boundary structure located in north-central Iowa. Cores were recovered from each of the major structural terranes, with 2 cores (M-3 and M-4) from the Terrace Terrane, 4 cores (M-2, M-2A, M-6, and M-9) from the Crater Moat, and 6 cores (M-1, M-5, M-7, M-8, M-10, and M-11) from the Central Peak. These supplemented 2 central peak cores (1-A and 2-A) drilled in 1953. The cores penetrated five major impact lithologies: (1) sedimentary clast breccia; (2) impact ejecta; (3) central peak crystallite rocks; (4) crystalline clast breccia with sandy matrix; and (5) crystallite clast breccia with a melt matrix. Descriptions and preliminary interpretations of these cores are presented.

A grid of one-dimensional low-mass star formation collapse models

NASA Astrophysics Data System (ADS)

Vaytet, N.; Haugbølle, T.

2017-02-01

Context. Numerical simulations of star formation are becoming ever more sophisticated, incorporating new physical processes in increasingly realistic set-ups. These models are being compared to the latest observations through state-of-the-art synthetic renderings that trace the different chemical species present in the protostellar systems. The chemical evolution of the interstellar and protostellar matter is very topical, with more and more chemical databases and reaction solvers available online to the community. Aims: The current study was developed to provide a database of relatively simple numerical simulations of protostellar collapse as a template library for observations of cores and very young protostars, and for researchers who wish to test their chemical modelling under dynamic astrophysical conditions. It was also designed to identify statistical trends that may appear when running many models of the formation of low-mass stars by varying the initial conditions. Methods: A large set of 143 calculations of the gravitational collapse of an isolated sphere of gas with uniform temperature and a Bonnor-Ebert-like density profile was undertaken using a 1D fully implicit Lagrangian radiation hydrodynamics code. The parameter space covered initial masses from 0.2 to 8 M⊙, temperatures of 5-30 K, and radii 3000 ≤ R0 ≤ 30 000 AU. Results: A spread due to differing initial conditions and optical depths, was found in the thermal evolutionary tracks of the runs. Within less than an order of magnitude, all first and second Larson cores had masses and radii essentially independent of the initial conditions. Radial profiles of the gas density, velocity, and temperature were found to vary much more outside of the first core than inside. The time elapsed between the formation of the first and second cores was found to strongly depend on the first core mass accretion rate, and no first core in our grid of models lived for longer than 2000 years before the onset of the second collapse. Conclusions: The end product of a protostellar cloud collapse, the second Larson core, is at birth a canonical object with a mass and radius of about 3 MJ and 8 RJ, independent of its initial conditions. The evolution sequence which brings the gas to stellar densities can, however, proceed in a variety of scenarios, on different timescales or along different isentropes, but each story line can largely be predicted by the initial conditions. All the data from the simulations are publicly available. The figures and raw data for every simulation output can be found at this address: http://starformation.hpc.ku.dk/grid-of-protostars. Copies of the outputs, as well as Table C.1, are also available in the form of static electronic tables at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/598/A116

Recutting prostate needle core biopsies with high grade prostatic intraepithelial neoplasia increases detection of adenocarcinoma.

PubMed

Rapp, David E; Msezane, Lambda P; Reynolds, W Stuart; Lotan, Tamara L; Obara, Piotr; O'Connor, R Corey; Taxy, Jerome B; Gerber, Glenn S; Zagaja, Gregory P

2009-02-01

We sought to evaluate the ability of biopsy core recutting to increase cancer detection in patients with high grade prostatic intraepithelial neoplasia (HGPIN). This prospective study encompasses all patients undergoing 12 core TRUS guided prostate biopsy between February 2004 and January 2007. In patients with HGPIN on initial biopsy, the paraffin blocks were resampled for cancer by additional deeper levels per core. Additional analysis was performed in the patients with HGPIN in order to detect whether significant differences in prebiopsy variables were associated with patients subsequently found to have benign versus carcinoma on recutting. Last, the costs associated with this procedure were studied. Forty of 584 (6.8%) patients undergoing prostate biopsy were found to have HGPIN in the absence of prostatic adenocarcinoma on initial histopathology. Following recutting, 12.5% (5/40) of these patients were found to have prostatic adenocarcinoma not previously detected. Of the remaining 35 patients, 18 underwent repeat biopsy. Of these, five patients were found to have adenocarcinoma and three were found to have persistent HGPIN. The PSA, PSA density (PSAD), and PSA velocity (PSAV) prior to initial biopsy were not statistically different when comparing patients found to have benign tissue versus carcinoma on recutting. In patients with HGPIN, at our institution, recutting the biopsy would yield a cost savings of $436/patient as opposed to universal rebiopsy. Our data suggest that prostate biopsy recutting may increase cancer detection in patients initially found to have HGPIN. Additionally, a significant cost savings is associated with the recutting protocol.

Whole planet coupling between climate, mantle, and core: Implications for rocky planet evolution

NASA Astrophysics Data System (ADS)

Foley, Bradford J.; Driscoll, Peter E.

2016-05-01

Earth's climate, mantle, and core interact over geologic time scales. Climate influences whether plate tectonics can take place on a planet, with cool climates being favorable for plate tectonics because they enhance stresses in the lithosphere, suppress plate boundary annealing, and promote hydration and weakening of the lithosphere. Plate tectonics plays a vital role in the long-term carbon cycle, which helps to maintain a temperate climate. Plate tectonics provides long-term cooling of the core, which is vital for generating a magnetic field, and the magnetic field is capable of shielding atmospheric volatiles from the solar wind. Coupling between climate, mantle, and core can potentially explain the divergent evolution of Earth and Venus. As Venus lies too close to the sun for liquid water to exist, there is no long-term carbon cycle and thus an extremely hot climate. Therefore, plate tectonics cannot operate and a long-lived core dynamo cannot be sustained due to insufficient core cooling. On planets within the habitable zone where liquid water is possible, a wide range of evolutionary scenarios can take place depending on initial atmospheric composition, bulk volatile content, or the timing of when plate tectonics initiates, among other factors. Many of these evolutionary trajectories would render the planet uninhabitable. However, there is still significant uncertainty over the nature of the coupling between climate, mantle, and core. Future work is needed to constrain potential evolutionary scenarios and the likelihood of an Earth-like evolution.

Genome-wide computational prediction and analysis of core promoter elements across plant monocots and dicots

USDA-ARS?s Scientific Manuscript database

Transcription initiation, essential to gene expression regulation, involves recruitment of basal transcription factors to the core promoter elements (CPEs). The distribution of currently known CPEs across plant genomes is largely unknown. This is the first large scale genome-wide report on the compu...

Standards Draw Heat in States

ERIC Educational Resources Information Center

Ujifusa, Andrew

2013-01-01

Opponents of the Common Core State Standards are ramping up legislative pressure and public relations efforts aimed at getting states to scale back--or even abandon--the high-profile initiative, even as implementation proceeds and tests aligned with the standards loom. Critics of the common core have focused recent lobbying and media efforts on…

The University of Dayton Core Program.

ERIC Educational Resources Information Center

Lasley, Thomas J., II; Geiger, John; Palermo, Patrick

This paper describes how the University of Dayton, Ohio, has strengthened teacher education through the creation of two institutional general education initiatives that integrate general and professional education in a coherent learning experience. The first is a CORE program that is open to all students pursuing degree work in the elementary…

A Comprehensive Horticulture Curriculum Guide for New Jersey Schools.

ERIC Educational Resources Information Center

Rutgers, The State Univ., New Brunswick, NJ. Cook Coll.

A horticultural core curriculum and draft copies of three horticultural cluster curricula are provided. Materials related to the curriculum development project appear first. The core curriculum is designed to provide broad initial instruction in horticulture for students in the first year of a secondary-level vocational horticulture program. The…

Teaching under Policy Cascades: Common Core and Literacy Instruction

ERIC Educational Resources Information Center

Papola-Ellis, Aimee

2014-01-01

Educational policies and initiatives significantly influence instruction in classrooms across the nation. This article presents data from a larger critical ethnographic study in an urban school in the United States during the school's first year implementing the Common Core State Standards. In this article, the author shares data from three…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wagner, B.

A specially designed wire line retrievable continuous coring system cored its initial project wells to total depth in hard rock formations in less than half the time that would have been required by conventional coring rigs. The hybrid wire line coring systems have since been used on other wells in similar lithologies, with a total of 38,000 m (124,640 ft) of hole cored and with penetration rates averaging 2.27 m/hr (7.45 ft/hr). This paper reports that Parker Drilling Co. designed the hybrid rigs and has recently been contracted to wire line core several holes for oil and gas exploration inmore » the Congo. The first core hole has been completed to 1,490 m, and total depth was reached in 21 days. The rig is now being mobilized to a second hole in the Congo.« less

IN-SYNC. II. Virial Stars from Subvirial Cores—the Velocity Dispersion of Embedded Pre-main-sequence Stars in NGC 1333

NASA Astrophysics Data System (ADS)

Foster, Jonathan B.; Cottaar, Michiel; Covey, Kevin R.; Arce, Héctor G.; Meyer, Michael R.; Nidever, David L.; Stassun, Keivan G.; Tan, Jonathan C.; Chojnowski, S. Drew; da Rio, Nicola; Flaherty, Kevin M.; Rebull, Luisa; Frinchaboy, Peter M.; Majewski, Steven R.; Skrutskie, Michael; Wilson, John C.; Zasowski, Gail

2015-02-01

The initial velocity dispersion of newborn stars is a major unconstrained aspect of star formation theory. Using near-infrared spectra obtained with the APOGEE spectrograph, we show that the velocity dispersion of young (1-2 Myr) stars in NGC 1333 is 0.92 ± 0.12 km s-1 after correcting for measurement uncertainties and the effect of binaries. This velocity dispersion is consistent with the virial velocity of the region and the diffuse gas velocity dispersion, but significantly larger than the velocity dispersion of the dense, star-forming cores, which have a subvirial velocity dispersion of 0.5 km s-1. Since the NGC 1333 cluster is dynamically young and deeply embedded, this measurement provides a strong constraint on the initial velocity dispersion of newly formed stars. We propose that the difference in velocity dispersion between stars and dense cores may be due to the influence of a 70 μG magnetic field acting on the dense cores or be the signature of a cluster with initial substructure undergoing global collapse.

Descriptive Metadata: Emerging Standards.

ERIC Educational Resources Information Center

Ahronheim, Judith R.

1998-01-01

Discusses metadata, digital resources, cross-disciplinary activity, and standards. Highlights include Standard Generalized Markup Language (SGML); Extensible Markup Language (XML); Dublin Core; Resource Description Framework (RDF); Text Encoding Initiative (TEI); Encoded Archival Description (EAD); art and cultural-heritage metadata initiatives;…

Core competencies in the science and practice of knowledge translation: description of a Canadian strategic training initiative.

PubMed

Straus, Sharon E; Brouwers, Melissa; Johnson, David; Lavis, John N; Légaré, France; Majumdar, Sumit R; McKibbon, K Ann; Sales, Anne E; Stacey, Dawn; Klein, Gail; Grimshaw, Jeremy

2011-12-09

Globally, healthcare systems are attempting to optimize quality of care. This challenge has resulted in the development of implementation science or knowledge translation (KT) and the resulting need to build capacity in both the science and practice of KT. We are attempting to meet these challenges through the creation of a national training initiative in KT. We have identified core competencies in this field and have developed a series of educational courses and materials for three training streams. We report the outline for this approach and the progress to date. We have prepared a strategy to develop, implement, and evaluate a national training initiative to build capacity in the science and practice of KT. Ultimately through this initiative, we hope to meet the capacity demand for KT researchers and practitioners in Canada that will lead to improved care and a strengthened healthcare system.

Core competencies in the science and practice of knowledge translation: description of a Canadian strategic training initiative

PubMed Central

2011-01-01

Background Globally, healthcare systems are attempting to optimize quality of care. This challenge has resulted in the development of implementation science or knowledge translation (KT) and the resulting need to build capacity in both the science and practice of KT. Findings We are attempting to meet these challenges through the creation of a national training initiative in KT. We have identified core competencies in this field and have developed a series of educational courses and materials for three training streams. We report the outline for this approach and the progress to date. Conclusions We have prepared a strategy to develop, implement, and evaluate a national training initiative to build capacity in the science and practice of KT. Ultimately through this initiative, we hope to meet the capacity demand for KT researchers and practitioners in Canada that will lead to improved care and a strengthened healthcare system. PMID:22152223

Probing the solar core with low-degree p modes

NASA Astrophysics Data System (ADS)

Roxburgh, I. W.; Vorontsov, S. V.

2002-01-01

We address the question of what could be learned about the solar core structure if the seismic data were limited to low-degree modes only. The results of three different experiments are described. The first is the linearized structural inversion of the p-mode frequencies of a solar model modified slightly in the energy-generating core, using the original (unmodified) model as an initial guess. In the second experiment, we invert the solar p-mode frequencies measured in the 32-month subset of BiSON data (Chaplin et al. 1998), degraded with additional 0.1 μHz random errors, using a model of 2.6 Gyr age from the solar evolutionary sequence as an initial approximation. This second inversion is non-linear. In the third experiment, we compare the same set of BiSON frequencies with current reference solar model.

Passive containment cooling system

DOEpatents

Conway, Lawrence E.; Stewart, William A.

1991-01-01

A containment cooling system utilizes a naturally induced air flow and a gravity flow of water over the containment shell which encloses a reactor core to cool reactor core decay heat in two stages. When core decay heat is greatest, the water and air flow combine to provide adequate evaporative cooling as heat from within the containment is transferred to the water flowing over the same. The water is heated by heat transfer and then evaporated and removed by the air flow. After an initial period of about three to four days when core decay heat is greatest, air flow alone is sufficient to cool the containment.

A summary of sodium-cooled fast reactor development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aoto, Kazumi; Dufour, Philippe; Hongyi, Yang

Much of the basic technology for the Sodium-cooled fast Reactor (SFR) has been established through long term development experience with former fast reactor programs, and is being confirmed by the Phénix end-of-life tests in France, the restart of Monju in Japan, the lifetime extension of BN-600 in Russia, and the startup of the China Experimental Fast Reactor in China. Planned startup in 2014 for new SFRs: BN-800 in Russia and PFBR in India, will further enhance the confirmation of the SFR basic technology. Nowadays, the SFR development has advanced to aiming at establishment of the Generation-IV system which is dedicatedmore » to sustainable energy generation and actinide management, and several advanced SFR concepts are under development such as PRISM, JSFR, ASTRID, PGSFR, BN-1200, and CFR-600. Generation-IV International Forum is an international collaboration framework where various R&D activities are progressing on design of system and component, safety and operation, advanced fuel, and actinide cycle for the Generation-IV SFR development, and will play a beneficial role of promoting them thorough providing an opportunity to share the past experience and the latest data of design and R&D among countries developing SFR.« less

Siegel[JMMM 7,312(`78)] FIRST EXPERIMENTAL DISCOVERY of Giant-Magnetoresistance Decade Pre ``Fert'' and ``Gruenberg'' ['88 - `78] = 10-Years = One-Decade Sounds, for Nuclear-Power Naïve ``Panacea'' for Global-Warming/Climate-Chan

NASA Astrophysics Data System (ADS)

Hoffmann, Masterace; Siegel, Edward

Siegel[JMMM 7,312(`78); Monju (12/'95) LMFBR PREDICTION!!!] following: Wigner[JAP 17,857(`46)]-(Alvin)Weinberg(ANL/ORNL/ANS)-(Sidney)Siegel(ANL/ORNL/ANS)-Seitz-Overhauser-Rollnick-Pollard-Lofaro-Markey-Pringle[Nuclear-PowerFrom Physics to Politics(`79)] FIRST EXPERIMENTAL DISCOVERY [Siegel<<<''Fert''-''Gruenberg'':2007-Physics-Nobel/2006:-Wolf/Japan-prizes:[`88 -`78] =10-years =1-decade precedence!!!] of granular giant-magnetoresistance(GMR) [Google: ``EDWARD SIEGEL GIANT-MAGNETORESISTANCE ICMAO 1977 FLICKER''] [Google: ``Ana Mayo If LEAKS`Could' KILL''] in austenitic/FCC Ni/Fe-based (so MIScalled)''super''alloy-182/82 transition-welds GENERIC ENDEMIC EXTANT detrimental (SYNONYMS): Wigner's-disease/Ostwald-ripening/spinodal-decompositio/OVERageing-EMBRITTLEMENT/THERMAL-leading-to-mechanical (TLTM)-INstability/``sensitization'' in: nuclear-reactors/spent-fuel dry-casks/refineries/jet/missile/rocket-engines/...SOUNDS A DIRE WARNING FOR NAIVE Hansen-Sommerville-Holdren-DOE-NRC-OSTP-WNA-NEI-AIP-APS-...calls/media-hype/P.R./spin-doctoring for carbon-``free'' nuclear-power as a SUPPOSED ``panacea'' for climate-change/global-warming: ``TRUST BUT VERIFY!!!'' ; a VERY LOUD CAVEAT EMPTOR!!!

Calculation of natural convection test at Phenix using the NETFLOW++ code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mochizuki, H.; Kikuchi, N.; Li, S.

2012-07-01

The present paper describes modeling and analyses of a natural convection of the pool-type fast breeder reactor Phenix. The natural convection test was carried out as one of the End of Life Tests of the Phenix. Objective of the present study is to assess the applicability of the NETFLOW++ code which has been verified thus far using various water facilities and validated using the plant data of the loop-type FBR 'Monju' and the loop-type experimental fast reactor 'Joyo'. The Phenix primary heat transport system is modeled based on the benchmark documents available from IAEA. The calculational model consists of onlymore » the primary heat transport system with boundary conditions on the secondary-side of IHX. The coolant temperature at the primary pump inlet, the primary coolant temperature at the IHX inlet and outlet, the secondary coolant temperatures and other parameters are calculated by the code where the heat transfer between the hot and cold pools is explicitly taken into account. A model including the secondary and tertiary systems was prepared, and the calculated results also agree well with the measured data in general. (authors)« less

On the long-term memory of the Greenland Ice Sheet

NASA Astrophysics Data System (ADS)

Rogozhina, I.; Martinec, Z.; Hagedoorn, J. M.; Thomas, M.; Fleming, K.

2011-03-01

In this study, the memory of the Greenland Ice Sheet (GIS) with respect to its past states is analyzed. According to ice core reconstructions, the present-day GIS reflects former climatic conditions dating back to at least 250 thousand years before the present (kyr BP). This fact must be considered when initializing an ice sheet model. The common initialization techniques are paleoclimatic simulations driven by atmospheric forcing inferred from ice core records and steady state simulations driven by the present-day or past climatic conditions. When paleoclimatic simulations are used, the information about the past climatic conditions is partly reflected in the resulting present-day state of the GIS. However, there are several important questions that need to be clarified. First, for how long does the model remember its initial state? Second, it is generally acknowledged that, prior to 100 kyr BP, the longest Greenland ice core record (GRIP) is distorted by ice-flow irregularities. The question arises as to what extent do the uncertainties inherent in the GRIP-based forcing influence the resulting GIS? Finally, how is the modeled thermodynamic state affected by the choice of initialization technique (paleo or steady state)? To answer these questions, a series of paleoclimatic and steady state simulations is carried out. We conclude that (1) the choice of an ice-covered initial configuration shortens the initialization simulation time to 100 kyr, (2) the uncertainties in the GRIP-based forcing affect present-day modeled ice-surface topographies and temperatures only slightly, and (3) the GIS forced by present-day climatic conditions is overall warmer than that resulting from a paleoclimatic simulation.

Mission Operations and Information Management Area Spacecraft Monitoring and Control Working Group

NASA Technical Reports Server (NTRS)

Lokerson, Donald C. (Editor)

2005-01-01

Working group goals for this year are: Goal 1. Due to many review comments the green books will be updated and available for re-review by CCSDS. Submission of green books to CCSDS for approval. Goal 2.Initial set of 4 new drafts of the red books as following: SM&C protocol: update with received comments. SM&C common services: update with received comments and expand the service specification. SM&C core services: update with received comments and expand the service the information model. SM&C time services: (target objective): produce initial draft following template of core services.

Potential connected vehicle applications to enhance mobility, safety, and environmental security.

DOT National Transportation Integrated Search

2012-02-01

The connected vehicle research initiative is the core of the U.S. Department of Transportations intelligent : transportation system research program. The initiative is beginning to gain momentum in the research : community because of the developme...

Luminescence signal profiling: a new proxy for sedimentologically "invisible" marine Mass Transport Deposits (MTDs)

NASA Astrophysics Data System (ADS)

López, Gloria I.; Bialik, Or; Waldmann, Nicolas

2017-04-01

When dealing with fine-grained, organic-rich, colour-monotone, underwater marine sediment cores retrieved from the continental shelf or slope, the initial visual impression, upon split-opening the vessels, is often of a "disappointing" homogeneous, monotonous, continuous archive. Only after thorough, micro- to macro-scale, multi-parameter investigations the sediment reveals its treasures, initially by performing some measurements on the intact core itself, hence depicting for the first time its contents, and subsequently by carrying out the destructive, multi-proxy sample-based analyses. Usually, routine Multi-Sensor Core Logger (MSCL) measurements of petrophysical parameters (e.g. magnetic susceptibility, density, P-Wave velocity) on un-split sediment cores are the first undertaken while still on-board in the field or back at the laboratory. Less often done, but equally valuable, are continuous X-Ray and CT scan imaging of the same intact archives. Upon splitting, routine granulometry, micro- and macro-fossil and invertebrate identification, total organic / inorganic carbon content (TOC / TIC), amid other analyses take place. The geochronology component is also established usually by AMS 14C on selected organic-rich units, and less common is Optically Stimulated Luminescence (OSL) dating used on the coarser-grained, siliciclastic layers. A relatively new tool used in Luminescence, the Portable OSL Reader, employed to rapidly assess the luminescence signal of untreated poly-mineral samples to assist with targeted field sampling for full OSL dating, was used for the first time in marine sediment cores as a novel petrophysical characterization tool with astonishing results. In this study, two 2 m-long underwater piston sediment cores recovered from 200 m depths on the continental shelf off-southern Israel, were subjected to pulsed-photon stimulation (PPSL) obtaining favourable luminescence signals along their entire lengths. Astoundingly, luminescence signals were obtained on both, already split-opened cores. Both cores depicted the monotonous characteristics of homogeneousness down-core as per most of the results obtained from the non-destructive and destructive tests. One of the cores showed several small higher energy events, including a Mass Transport Deposit (MTD) within its first 10 cm, only fully visible on the CT scan imaging, the PPSL profile and particle size distribution plot. This initial investigation demonstrates the feasibility and usefulness of luminescence profiling as a new sedimentological and petrophysical proxy to better visualize homogeneous yet complex, fine-grained, underwater archives. Moreover, it helps to understand the continuity of the stratigraphy and linearity of deposition of the sediment, besides assisting on the estimation of relative ages provided that good OSL ages are obtained throughout the recovered archive.

The Dynamics of Massive Starless Cores with ALMA

NASA Astrophysics Data System (ADS)

Tan, Jonathan C.; Kong, Shuo; Butler, Michael J.; Caselli, Paola; Fontani, Francesco

2013-12-01

How do stars that are more massive than the Sun form, and thus how is the stellar initial mass function (IMF) established? Such intermediate- and high-mass stars may be born from relatively massive pre-stellar gas cores, which are more massive than the thermal Jeans mass. The turbulent core accretion model invokes such cores as being in approximate virial equilibrium and in approximate pressure equilibrium with their surrounding clump medium. Their internal pressure is provided by a combination of turbulence and magnetic fields. Alternatively, the competitive accretion model requires strongly sub-virial initial conditions that then lead to extensive fragmentation to the thermal Jeans scale, with intermediate- and high-mass stars later forming by competitive Bondi-Hoyle accretion. To test these models, we have identified four prime examples of massive (~100 M ⊙) clumps from mid-infrared extinction mapping of infrared dark clouds. Fontani et al. found high deuteration fractions of N2H+ in these objects, which are consistent with them being starless. Here we present ALMA observations of these four clumps that probe the N2D+ (3-2) line at 2.''3 resolution. We find six N2D+ cores and determine their dynamical state. Their observed velocity dispersions and sizes are broadly consistent with the predictions of the turbulent core model of self-gravitating, magnetized (with Alfvén Mach number mA ~ 1) and virialized cores that are bounded by the high pressures of their surrounding clumps. However, in the most massive cores, with masses up to ~60 M ⊙, our results suggest that moderately enhanced magnetic fields (so that mA ~= 0.3) may be needed for the structures to be in virial and pressure equilibrium. Magnetically regulated core formation may thus be important in controlling the formation of massive cores, inhibiting their fragmentation, and thus helping to establish the stellar IMF.

Comments on the feasibility of developing gas core nuclear reactors. [for manned interplanetary spacecraft propulsion

NASA Technical Reports Server (NTRS)

Rom, F. E.

1969-01-01

Recent developments in the fields of gas core hydrodynamics, heat transfer, and neutronics indicate that gas core nuclear rockets may be feasible from the point of view of basic principles. Based on performance predictions using these results, mission analyses indicate that gas core nuclear rockets may have the potential for reducing the initial weight in orbit of manned interplanetary vehicles by a factor of 5 when compared to the best chemical rocket systems. In addition, there is a potential for reducing total trip times from 450 to 500 days for chemical systems to 250 to 300 days for gas core systems. The possibility of demonstrating the feasibility of gas core nuclear rocket engines by means of a logical series of experiments of increasing difficulty that ends with ground tests of full scale gas core reactors is considered.

Entering the Historical Problem Space: Whole-Class Text-Based Discussion in History Class

ERIC Educational Resources Information Center

Reisman, Abby

2015-01-01

Background/Context: The Common Core State Standards Initiative reveals how little we understand about the components of effective discussion-based instruction in disciplinary history. Although the case for classroom discussion as a core method for subject matter learning stands on stable theoretical and empirical ground, to date, none of the…

Voter Perceptions: Common Core State Standards & Tests

ERIC Educational Resources Information Center

Achieve, Inc., 2014

2014-01-01

Since June 2010, 46 states and Washington DC have adopted the Common Core State Standards (CCSS)--K-12 standards in mathematics and English language arts/literacy developed through a multi-state initiative led by the National Governors Association and the Council of Chief State School Officers. Implementation of the standards is underway in all of…

Beyond the Core: Assessing Authentic 21st Century Skills

ERIC Educational Resources Information Center

Greenstein, Laura

2012-01-01

Principals' wheelbarrows are full of initiatives: closing learning gaps, preparing for the Common Core State Standards, differentiating instruction, and improving college and career readiness, to name a few. Meanwhile, principals have too few assets in their toolboxes to meet all the hefty demands. Taking the long view, it becomes clear that true…

Literacy at the Core of the Delaware World Language Immersion Programs

ERIC Educational Resources Information Center

Fulton-Archer, Lynn

2013-01-01

Certain aspects of the implementation of language immersion programs in Delaware are unique given the state's size, demographics, and role in national education initiatives including Race to the Top, Common Core, and Smarter Balance. The Delaware experience typifies what every state, district, or even school goes through as they try to provide…

Smart Money? Philanthropic and Federal Funding for the Common Core

ERIC Educational Resources Information Center

Kornhaber, Mindy L.; Barkauskas, Nikolaus J.; Griffith, Kelly M.

2016-01-01

The Common Core State Standards Initiative seeks to prepare all students to graduate high school without remedial needs, to improve transparency across states' accountability systems, and to foster efficiencies in the development and distribution of educational resources. The reform was adopted in more than 40 states and has been described as…

Social Media Is the New Player in the Politics of Education

ERIC Educational Resources Information Center

Supovitz, Jonathan

2017-01-01

Political debate about the Common Core State Standards (the first major education policy initiative in the social media age) ramped up quickly on social media, particularly on Twitter. However, while the increased and intense conversation influenced many states to disavow Common Core in name, those states ended up adopting standards that were…

Virginia Standards Predated the Common Core Initiative

ERIC Educational Resources Information Center

Knowledge Quest, 2014

2014-01-01

The Virginia Board of Education is committed to the Virginia Standards of Learning (SOL) program and opposed to adoption of the newly developed Common Core State Standards as a prerequisite for participation in federal competitive grant and entitlement programs. The Standards of Learning are clear and rigorous and have won the acceptance and trust…

Effects of Enhanced Anchored Instruction on Skills Aligned to Common Core Math Standards

ERIC Educational Resources Information Center

Bottge, Brian A.; Cho, Sun-Joo

2013-01-01

This study compared how students with learning difficulties in math (MLD) who were randomly assigned to two instructional conditions answered items on problem solving tests aligned to the Common Core State Standards Initiative for Mathematics. Posttest scores showed improvement in the math performance of students receiving Enhanced Anchored…

Common Core Standards: The Emperor Has No Clothes, or Evidence

ERIC Educational Resources Information Center

Tienken, Christopher H.

2011-01-01

The Common Core State Standards (CCSS) initiative continues to gather strength. But the evidence presented by its developers--the National Governors Association (NGA) and the Council of Chief State School Officers (CCSSO)--seems lacking compared to the independent reviews and the available research on the topic that suggest otherwise. In this…

Almost There? The Road to Common Standards Reaches a Milestone

ERIC Educational Resources Information Center

Parker-Burgard, Don

2009-01-01

The Common Core State Standards Initiative is a collaborative effort between the Council of Chief State School Officers (CCSSO) and the National Governors Association (NGA) that is developing core K12 standards in English-language arts and math. The current patchwork of state standards makes it difficult, if not impossible, to evaluate student…

States' Progress and Challenges in Implementing Common Core State Standards

ERIC Educational Resources Information Center

Kober, Nancy; Rentmer, Diane Stark

2011-01-01

Most states are participating in the initiative led by the National Governors Association and the Council of Chief State School Officers to develop and adopt voluntary common core state standards that will outline what elementary and secondary school students are expected to learn in English language arts and mathematics. Implementing these…

The Common Core State Standards: The Emperor Is Still Looking for His Clothes

ERIC Educational Resources Information Center

Tienken, Christopher H.

2012-01-01

As of September 2012, only Alaska, Minnesota, Nebraska, Texas, and Virginia had not adopted the Common Core State Standards (CCSS). Yet empirical evidence that demonstrates the efficacy of the initiative remains elusive. The Emperor has no clothes (Tienken 2011a). This latest installment of standardization and centralization of curriculum and…

Now What? Imperatives & Options for "Common Core" Implementation & Governance

ERIC Educational Resources Information Center

Finn, Chester E., Jr.; Petrilli, Michael J.

2010-01-01

Over the past year, the nation's governors and state school chiefs have achieved laudable consensus around a set of math and English standards, developed voluntarily and without federal involvement through the Common Core State Standards Initiative (CCSSI). Most states have signed on to them. More recently, the states have again teamed up--this…

Writing Instruction in First Grade: An Observational Study

ERIC Educational Resources Information Center

Coker, David L., Jr.; Farley-Ripple, Elizabeth; Jackson, Allison F.; Wen, Huijing; MacArthur, Charles A.; Jennings, Austin S.

2016-01-01

As schools work to meet the ambitious Common Core State Standards in writing (Common Core State Standards Initiation, 2010), instructional approaches are likely to be examined. However, there is little research that describes the current state of instruction. This study was designed to expand the empirical base on writing instruction in first…

Translating the Common Core State Standards

ERIC Educational Resources Information Center

Tienken, Christopher H.; Orlich, Donald C.

2013-01-01

As the authors describe in Chapter 7 of their new book, "The School Reform Landscape: Fraud, Myth, and Lies," the Common Core State Standards (CCSS) initiative continues to ramble on, without evidence to support its efficacy. That is because education reform in the United States is being driven largely by ideology, rhetoric, and dogma instead of…

How ASCD Supports the Common Core

ERIC Educational Resources Information Center

Mercado, Efrain; Britt, Sherida

2013-01-01

As the Common Core State Standards Initiative moved from the development and adoption of the standards to their implementation, ASCD embarked on a multifaceted program to help educators understand and implement the new standards. With support from a $3 million grant from the Bill and Melinda Gates Foundation, ASCD has enacted a three-pronged…

Structure-Function Analysis of the Drosophila melanogaster Caudal Transcription Factor Provides Insights into Core Promoter-preferential Activation.

PubMed

Shir-Shapira, Hila; Sharabany, Julia; Filderman, Matan; Ideses, Diana; Ovadia-Shochat, Avital; Mannervik, Mattias; Juven-Gershon, Tamar

2015-07-10

Regulation of RNA polymerase II transcription is critical for the proper development, differentiation, and growth of an organism. The RNA polymerase II core promoter is the ultimate target of a multitude of transcription factors that control transcription initiation. Core promoters encompass the RNA start site and consist of functional elements such as the TATA box, initiator, and downstream core promoter element (DPE), which confer specific properties to the core promoter. We have previously discovered that Drosophila Caudal, which is a master regulator of genes involved in development and differentiation, is a DPE-specific transcriptional activator. Here, we show that the mouse Caudal-related homeobox (Cdx) proteins (mCdx1, mCdx2, and mCdx4) are also preferential core promoter transcriptional activators. To elucidate the mechanism that enables Caudal to preferentially activate DPE transcription, we performed structure-function analysis. Using a systematic series of deletion mutants (all containing the intact DNA-binding homeodomain) we discovered that the C-terminal region of Caudal contributes to the preferential activation of the fushi tarazu (ftz) Caudal target gene. Furthermore, the region containing both the homeodomain and the C terminus of Caudal was sufficient to confer core promoter-preferential activation to the heterologous GAL4 DNA-binding domain. Importantly, we discovered that Drosophila CREB-binding protein (dCBP) is a co-activator for Caudal-regulated activation of ftz. Strikingly, dCBP conferred the ability to preferentially activate the DPE-dependent ftz reporter to mini-Caudal proteins that were unable to preferentially activate ftz transcription themselves. Taken together, it is the unique combination of dCBP and Caudal that enables the co-activation of ftz in a core promoter-preferential manner. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative.

PubMed

Jack, Clifford R; Bernstein, Matt A; Borowski, Bret J; Gunter, Jeffrey L; Fox, Nick C; Thompson, Paul M; Schuff, Norbert; Krueger, Gunnar; Killiany, Ronald J; Decarli, Charles S; Dale, Anders M; Carmichael, Owen W; Tosun, Duygu; Weiner, Michael W

2010-05-01

Functions of the Alzheimer's Disease Neuroimaging Initiative (ADNI) magnetic resonance imaging (MRI) core fall into three categories: (1) those of the central MRI core laboratory at Mayo Clinic, Rochester, Minnesota, needed to generate high quality MRI data in all subjects at each time point; (2) those of the funded ADNI MRI core imaging analysis groups responsible for analyzing the MRI data; and (3) the joint function of the entire MRI core in designing and problem solving MR image acquisition, pre-processing, and analyses methods. The primary objective of ADNI was and continues to be improving methods for clinical trials in Alzheimer's disease. Our approach to the present ("ADNI-GO") and future ("ADNI-2," if funded) MRI protocol will be to maintain MRI methodological consistency in the previously enrolled "ADNI-1" subjects who are followed up longitudinally in ADNI-GO and ADNI-2. We will modernize and expand the MRI protocol for all newly enrolled ADNI-GO and ADNI-2 subjects. All newly enrolled subjects will be scanned at 3T with a core set of three sequence types: 3D T1-weighted volume, FLAIR, and a long TE gradient echo volumetric acquisition for micro hemorrhage detection. In addition to this core ADNI-GO and ADNI-2 protocol, we will perform vendor-specific pilot sub-studies of arterial spin-labeling perfusion, resting state functional connectivity, and diffusion tensor imaging. One of these sequences will be added to the core protocol on systems from each MRI vendor. These experimental sub-studies are designed to demonstrate the feasibility of acquiring useful data in a multicenter (but single vendor) setting for these three emerging MRI applications. Copyright 2010 The Alzheimer

Core competencies for emergency medicine clerkships: results of a Canadian consensus initiative.

PubMed

Penciner, Rick; Woods, Robert A; McEwen, Jill; Lee, Richard; Langhan, Trevor; Bandiera, Glen

2013-01-01

There is no consensus on what constitutes the core competencies for emergency medicine (EM) clerkship rotations in Canada. Existing EM curricula have been developed through informal consensus and often focus on EM content to be known at the end of training rather than what is an appropriate focus for a time-limited rotation in EM. We sought to define the core competencies for EM clerkship in Canada through consensus among an expert panel of Canadian EM educators. We used a modified Delphi method and the CanMEDS 2005 Physician Competency Framework to develop a consensus among expert EM educators from across Canada. Thirty experts from nine different medical schools across Canada participated on the panel. The initial list consisted of 152 competencies organized in the seven domains of the CanMEDS 2005 Physician Competency Framework. After the second round of the Delphi process, the list of competencies was reduced to 62 (59% reduction). A complete list of competencies is provided. This study established a national consensus defining the core competencies for EM clerkship in Canada.

Initial 60Fe Abundance in the Solar Nebula Constrained by Delayed Onset of a Planetesimal Dynamo

NASA Astrophysics Data System (ADS)

Wang, H.; Weiss, B. P.; Crowley, J.

2017-12-01

The paleomagnetism of meteorites provides evidence for advecting metallic core dynamos and large-scale differentiation on their parent planetesimals. Their small sizes relative to planets enable new opportunities to understand the physics of dynamo generation. Wang et al. [2017] studied the paleomagnetism of three volcanic angrites (D'Orbigny, 4563.37±0.12 Ma; Sahara 99555, 4563.54±0.14 Ma; Asuka 881371, 4562.4±1.6 Ma) and one plutonic angrite (Angra dos Reis, 4556.51±0.11 Ma). Their results show that the older volcanic angrites recorded no detectable paleomagnetic field, while the younger plutonic angrite recorded a paleomagnetic field of 17 µT interpreted as evidence of a core dynamo on the angrite parent body (APB). This indicates that the initiation of the APB dynamo was delayed until sometime between 4 and 11 My after the formation of calcium aluminum-rich inclusions (CAIs) at 4567.30 ± 0.16 Ma. This late timing is consistent with recent planetesimal thermal evolution models invoking shallow magma oceans [Neumann et al. 2014], which predict that planetesimal dynamos would not initiate until the core began to crystallize. It is also consistent with thermal evolution models invoking large-scale magma oceans that considered thermal blanketing of the core by 26Al decay in the mantle [Roberts et al. 2013, Sterenborg and Crowley 2013], which would delay thermal convection dynamos until several My after accretion (occurred <0.25 My after CAIs for the APB [Schiller et al. 2015]) and differentiation. Because the presence of even a small amount of 60Fe in the core could effectively remove the thermal blanketing effect of mantle 26Al, we can use the delay in timing of the dynamo to constrain the abundance of 60Fe on the APB. Our planetesimal thermal evolution models show that if the initial solar nebula 60Fe/56Fe ratio was greater than 5×10-9, the APB core dynamo would have to start earlier than 4 My after CAIs, in contradiction to the paleomagnetic constraints. Thus, we argue that 5×10-9 is an upper limit of the initial 60Fe/56Fe ratio in the solar nebula. This upper limit is consistent with independent isotopic measurements of the Sahara 99555 angrite, which found 60Fe/56Fe ratio of (6.96 ± 1.60)×10-9 [Tang and Dauphas, 2015].

Iron snow in the Martian Core?

NASA Astrophysics Data System (ADS)

Davies, C. J.; Pommier, A.

2017-12-01

The decline of Mars' global magnetic field some 3.8-4.1 billion years ago is thought to reflect the demise of the dynamo that operated in its liquid core. The termination of the dynamo is intimately tied to the thermochemical evolution of the core-mantle system and therefore to the present-day physical state of the Martian core. The standard model predicts that the Martian dynamo failed because thermal convection stopped and the core remained entirely liquid until the present. Here we consider an alternative hypothesis that the Martian core crystallized from the top down in the so-called iron snow regime. We derive energy-entropy equations describing the long-timescale thermal and magnetic evolution of the core that incorporate the self-consistent formation of a snow layer that freezes out pure iron and is assumed to be on the liquidus; the iron sinks and remelts in the deeper core, acting as a possible source for magnetic field generation. Compositions are in the FeS system, with a sulfur content up to 16 wt%. The values of the different parameters (core radius, density and CMB pressure) are varied within bounds set by recent internal structure models that satisfy existing geodetic constraints (planetary mass, moment of inertia and tidal Love number). The melting curve and adiabat, CMB heat flow and thermal conductivity were also varied, based on previous experimental and numerical works. We observe that the formation of snow zones occurs for a wide range of interior and thermal structure properties and depends critically on the initial sulfur concentration. Gravitational energy release and latent heat effects arising during growth of the snow zone do not generate sufficient entropy to restart the dynamo unless the snow zone occupies a significant fraction of the core. Our results suggest that snow zones can be 1.5-2 Gyrs old, though thermal stratification of the uppermost core, not included in our model, likely delays onset. Models that match the available magnetic and geodetic constraints have an initial S concentration of about 10wt.% and snow zones that occupy approximately the top 100 km of the present-day Martian core.

Cross talk analysis in multicore optical fibers by supermode theory.

PubMed

Szostkiewicz, Lukasz; Napierala, Marek; Ziolowicz, Anna; Pytel, Anna; Tenderenda, Tadeusz; Nasilowski, Tomasz

2016-08-15

We discuss the theoretical aspects of core-to-core power transfer in multicore fibers relying on supermode theory. Based on a dual core fiber model, we investigate the consequences of this approach, such as the influence of initial excitation conditions on cross talk. Supermode interpretation of power coupling proves to be intuitive and thus may lead to new concepts of multicore fiber-based devices. As a conclusion, we propose a definition of a uniform cross talk parameter that describes multicore fiber design.

Options for Parallelizing a Planning and Scheduling Algorithm

NASA Technical Reports Server (NTRS)

Clement, Bradley J.; Estlin, Tara A.; Bornstein, Benjamin D.

2011-01-01

Space missions have a growing interest in putting multi-core processors onboard spacecraft. For many missions processing power significantly slows operations. We investigate how continual planning and scheduling algorithms can exploit multi-core processing and outline different potential design decisions for a parallelized planning architecture. This organization of choices and challenges helps us with an initial design for parallelizing the CASPER planning system for a mesh multi-core processor. This work extends that presented at another workshop with some preliminary results.

Influence of Non-spherical Initial Stellar Structure on the Core-Collapse Supernova Mechanism

NASA Astrophysics Data System (ADS)

Couch, Sean M.

I review the state of investigation into the impact that nonspherical stellar progenitor structure has on the core-collapse supernova mechanism. Although modeling stellar evolution relies on 1D spherically symmetric calculations, massive stars are not truly spherical. In the stellar evolution codes, this fact is accounted for by "fixes" such as mixing length theory and attendant modifications. Of particular relevance to the supernova mechanism, the Si- and O-burning shells surrounding the iron core at the point of collapse can be violently convective, with convective speeds of hundreds of km s-1. It has recently been shown by a number of groups that the presence of nonspherical perturbations in the layers surrounding the collapsing iron core can have a favorable impact on the likelihood for shock revival and explosion via the neutrino heating mechanism. This is due in large part to the strengthening of turbulence behind the stalled shock due to the presence of finite amplitude seed perturbations to speed the growth of convection which drives the post-shock turbulence. Efforts are now underway to simulate the final minutes of stellar evolution to core-collapse in 3D with the aim to generate realistic multidimensional initial conditions for use in simulations of the supernova mechanism.

Centennial-scale records of total organic carbon in sediment cores from the South Yellow Sea, China

NASA Astrophysics Data System (ADS)

Zhu, Qing; Lin, Jia; Hong, Yuehui; Yuan, Lirong; Liu, Jinzhong; Xu, Xiaoming; Wang, Jianghai

2018-01-01

Global carbon cycling is a significant factor that controls climate change. The centennial-scale variations in total organic carbon (TOC) contents and its sources in marginal sea sediments may reflect the influence of human activities on global climate change. In this study, two fine-grained sediment cores from the Yellow Sea Cold Water Mass of the South Yellow Sea were used to systematically determine TOC contents and stable carbon isotope ratios. These results were combined with previous data of black carbon and 210Pb dating from which we reconstructed the centennial-scale initial sequences of TOC, terrigenous TOC (TOCter) and marine autogenous TOC (TOCmar) after selecting suitable models to correct the measured TOC (TOCcor). These sequences showed that the TOCter decreased with time in the both cores while the TOCmar increased, particularly the rapid growth in core H43 since the late 1960s. According to the correlation between the Huanghe (Yellow) River discharge and the TOCcor, TOCter, or TOCmar, we found that the TOCter in the two cores mainly derived from the Huanghe River and was transported by it, and that higher Huanghe River discharge could strengthen the decomposition of TOCmar. The newly obtained initial TOC sequences provide important insights into the interaction between human activities and natural processes.

Distortion of Magnetic Fields in a Starless Core II: 3D Magnetic Field Structure of FeSt 1-457

NASA Astrophysics Data System (ADS)

Kandori, Ryo; Tamura, Motohide; Tomisaka, Kohji; Nakajima, Yasushi; Kusakabe, Nobuhiko; Kwon, Jungmi; Nagayama, Takahiro; Nagata, Tetsuya; Tatematsu, Ken'ichi

2017-10-01

Three-dimensional (3D) magnetic field information on molecular clouds and cores is important for revealing their kinematical stability (magnetic support) against gravity, which is fundamental for studying the initial conditions of star formation. In the present study, the 3D magnetic field structure of the dense starless core FeSt 1-457 is determined based on the near-infrared polarimetric observations of the dichroic polarization of background stars and simple 3D modeling. With an obtained angle of line-of-sight magnetic inclination axis {θ }{inc} of 45^\\circ +/- 10^\\circ and previously determined plane-of-sky magnetic field strength {B}{pol} of 23.8 ± 12.1 μ {{G}}, the total magnetic field strength for FeSt 1-457 is derived to be 33.7 ± 18.0 μ {{G}}. The critical mass of FeSt 1-457, evaluated using both magnetic and thermal/turbulent support is {M}{cr}=3.70+/- 0.92 {M}⊙ , which is identical to the observed core mass, {M}{core}=3.55+/- 0.75 {M}⊙ . We thus conclude that the stability of FeSt 1-457 is in a condition close to the critical state. Without infalling gas motion and no associated young stars, the core is regarded to be in the earliest stage of star formation, I.e., the stage just before the onset of dynamical collapse following the attainment of a supercritical condition. These properties could make FeSt 1-457 one of the best starless cores for future studies of the initial conditions of star formation.

Brown adipose tissue thermogenesis does not explain the intra-administration hyperthermic sign-reversal induced by serial administrations of 60% nitrous oxide to rats.

PubMed

Al-Noori, Salwa; Ramsay, Douglas S; Cimpan, Andreas; Maltzer, Zoe; Zou, Jessie; Kaiyala, Karl J

2016-08-01

Initial administration of ≥60% nitrous oxide (N2O) to rats promotes hypothermia primarily by increasing whole-body heat loss. We hypothesized that the drug promotes heat loss via the tail and might initially inhibit thermogenesis via brown adipose tissue (BAT), major organs of thermoregulation in rodents. Following repeated administrations, N2O inhalation evokes hyperthermia underlain by increased whole-body heat production. We hypothesized that elevated BAT thermogenesis plays a role in this thermoregulatory sign reversal. Using dual probe telemetric temperature implants and infrared (IR) thermography, we assessed the effects of nine repeated 60% N2O administrations compared to control (con) administrations on core temperature, BAT temperature, lumbar back temperature and tail temperature. Telemetric core temperature, telemetric BAT temperature, and IR BAT temperature were reduced significantly during initial 60% N2O inhalation (p≤0.001 compared to con). IR thermography revealed that acute N2O administration unexpectedly reduced tail temperature (p=0.0001) and also inhibited IR lumbar temperature (p<0.0001). In the 9th session, N2O inhalation significantly increased telemetric core temperature (p=0.007) indicative of a hyperthermic sign reversal, yet compared to control administrations, telemetric BAT temperature (p=0.86), IR BAT temperature (p=0.85) and tail temperature (p=0.47) did not differ significantly. Thus, an initial administration of 60% N2O at 21°C may promote hypothermia via reduced BAT thermogenesis accompanied by tail vasoconstriction as a compensatory mechanism to limit body heat loss. Following repeated N2O administrations rats exhibit a hyperthermic core temperature but a normalized BAT temperature, suggesting induction of a hyperthermia-promoting thermogenic adaptation of unknown origin. Copyright © 2016 Elsevier Ltd. All rights reserved.

Helical vortices: Quasiequilibrium states and their time evolution

NASA Astrophysics Data System (ADS)

Selçuk, Can; Delbende, Ivan; Rossi, Maurice

2017-08-01

The time evolution of a viscous helical vortex is investigated by direct numerical simulations of the Navier-Stokes equations where helical symmetry is enforced. Using conservation laws in the framework of helical symmetry, we elaborate an initial condition consisting in a finite core vortex, the time evolution of which leads to a generic quasiequilibrium state independent of the initial core size. Numerical results at different helical pitch values provide an accurate characterization in time for such helical states, for which specific techniques have been introduced: helix radius, angular velocity, stream function-velocity-vorticity relationships, and core properties (size, self-similarity, and ellipticity). Viscosity is shown to be at the origin of a small helical velocity component, which we relate to the helical vorticity component. Finally, changes in time of the flow topology are studied using the helical stream function and three-dimensional Lagrangian orbits.

Compact pulse generators with soft ferromagnetic cores driven by gunpowder and explosive.

PubMed

Ben, Chi; He, Yong; Pan, Xuchao; Chen, Hong; He, Yuan

2015-12-01

Compact pulse generators which utilized soft ferromagnets as an initial energy carrier inside multi-turn coil and hard ferromagnets to provide the initial magnetic field outside the coil have been studied. Two methods of reducing the magnetic flux in the generators have been studied: (1) by igniting gunpowder to launch the core out of the generator, and (2) by detonating explosives that demagnetize the core. Several types of compact generators were explored to verify the feasibility. The generators with an 80-turn coil that utilize gunpowder were capable of producing pulses with amplitude 78.6 V and the full width at half maximum was 0.41 ms. The generators with a 37-turn coil that utilize explosive were capable of producing pulses with amplitude 1.41 kV and the full width at half maximum was 11.68 μs. These two methods were both successful, but produce voltage waveforms with significantly different characteristics.

Sodium Based Heat Pipe Modules for Space Reactor Concepts: Stainless Steel SAFE-100 Core

NASA Technical Reports Server (NTRS)

Martin, James J.; Reid, Robert S.

2004-01-01

A heat pipe cooled reactor is one of several candidate reactor cores being considered for advanced space power and propulsion systems to support future space exploration applications. Long life heat pipe modules, with designs verified through a combination of theoretical analysis and experimental lifetime evaluations, would be necessary to establish the viability of any of these candidates, including the heat pipe reactor option. A hardware-based program was initiated to establish the infrastructure necessary to build heat pipe modules. This effort, initiated by Los Alamos National Laboratory and referred to as the Safe Affordable Fission Engine (SAFE) project, set out to fabricate and perform non-nuclear testing on a modular heat pipe reactor prototype that can provide 100 kilowatt from the core to an energy conversion system at 700 C. Prototypic heat pipe hardware was designed, fabricated, filled, closed-out and acceptance tested.

Analysis of an Aircraft Honeycomb Sandwich Panel with Circular Face Sheet/Core Disbond Subjected to Ground-Air Pressurization

NASA Technical Reports Server (NTRS)

Rinker, Martin; Krueger, Ronald; Ratcliffe, James

2013-01-01

The ground-air pressurization of lightweight honeycomb sandwich structures caused by alternating pressure differences between the enclosed air within the honeycomb core and the ambient environment is a well-known and controllable loading condition of aerospace structures. However, initial face sheet/core disbonds intensify the face sheet peeling effect of the internal pressure load significantly and can decrease the reliability of the sandwich structure drastically. Within this paper, a numerical parameter study was carried out to investigate the criticality of initial disbonds in honeycomb sandwich structures under ground-air pressurization. A fracture mechanics approach was used to evaluate the loading at the disbond front. In this case, the strain energy release rate was computed via the Virtual Crack Closure Technique. Special attention was paid to the pressure-deformation coupling which can decrease the pressure load within the disbonded sandwich section significantly when the structure is highly deformed.

Tuning the synthesis of platinum-copper nanoparticles with a hollow core and porous shell for the selective hydrogenation of furfural to furfuryl alcohol.

PubMed

Huang, Shuangshuang; Yang, Nating; Wang, Shibin; Sun, Yuhan; Zhu, Yan

2016-08-07

Pt-Cu nanoparticles constructed with a hollow core and porous shell have been synthesized in which Pt-Cu cages with multiporous outermost shells are formed at the initial stage and then the Pt and Cu atoms in solution continuously fed these hollow-core of cages by passing through the porous tunnels of the outermost shells, finally leading to the formation of hollow structures with different sizes. Furthermore, these hollow-core Pt-Cu nanoparticles are more effective than the solid-core Pt-Cu nanoparticles for the catalytic hydrogenation of furfural toward furfuryl alcohol. The former can achieve almost 100% conversion of furfural with 100% selectivity toward the alcohol.

Nonlinear combining and compression in multicore fibers

DOE PAGES

Chekhovskoy, I. S.; Rubenchik, A. M.; Shtyrina, O. V.; ...

2016-10-25

In this paper, we demonstrate numerically light-pulse combining and pulse compression using wave-collapse (self-focusing) energy-localization dynamics in a continuous-discrete nonlinear system, as implemented in a multicore fiber (MCF) using one-dimensional (1D) and 2D core distribution designs. Large-scale numerical simulations were performed to determine the conditions of the most efficient coherent combining and compression of pulses injected into the considered MCFs. We demonstrate the possibility of combining in a single core 90% of the total energy of pulses initially injected into all cores of a 7-core MCF with a hexagonal lattice. Finally, a pulse compression factor of about 720 can bemore » obtained with a 19-core ring MCF.« less

Mass spectrometry of Escherichia coli RNA polymerase: interactions of the core enzyme with sigma70 and Rsd protein.

PubMed

Ilag, Leopold L; Westblade, Lars F; Deshayes, Caroline; Kolb, Annie; Busby, Stephen J W; Robinson, Carol V

2004-02-01

The E. coli RNA polymerase core enzyme is a multisubunit complex of 388,981 Da. To initiate transcription at promoters, the core enzyme associates with a sigma subunit to form holo RNA polymerase. Here we have used nanoflow electrospray mass spectrometry, coupled with tandem mass spectrometry, to probe the interaction of the RNA polymerase core enzyme with the most abundant sigma factor, sigma70. The results show remarkably well-resolved spectra for both the core and holo RNA polymerases. The regulator of sigma70, Rsd protein, has previously been identified as a protein that binds to free sigma70. We show that Rsd also interacts with core enzyme. In addition, by adding increasing amounts of Rsd, we show that sigma70 is displaced from holo RNA polymerase, resulting in complexes of Rsd with core and sigma70. The results argue for a model in which Rsd not only sequesters sigma70, but is also an effector of core RNA polymerase.

Numerical and analytical simulation of the production process of ZrO2 hollow particles

NASA Astrophysics Data System (ADS)

Safaei, Hadi; Emami, Mohsen Davazdah

2017-12-01

In this paper, the production process of hollow particles from the agglomerated particles is addressed analytically and numerically. The important parameters affecting this process, in particular, the initial porosity level of particles and the plasma gun types are investigated. The analytical model adopts a combination of quasi-steady thermal equilibrium and mechanical balance. In the analytical model, the possibility of a solid core existing in agglomerated particles is examined. In this model, a range of particle diameters (50μm ≤ D_{p0} ≤ 160 μ m) and various initial porosities ( 0.2 ≤ p ≤ 0.7) are considered. The numerical model employs the VOF technique for two-phase compressible flows. The production process of hollow particles from the agglomerated particles is simulated, considering an initial diameter of D_{p0} = 60 μm and initial porosity of p = 0.3, p = 0.5, and p = 0.7. Simulation results of the analytical model indicate that the solid core diameter is independent of the initial porosity, whereas the thickness of the particle shell strongly depends on the initial porosity. In both models, a hollow particle may hardly develop at small initial porosity values ( p < 0.3), while the particle disintegrates at high initial porosity values ( p > 0.6.

SPRUCE Peat Physical and Chemical Characteristics from Experimental Plot Cores, 2012

DOE Data Explorer

Iversen, C. M. [Oak Ridge National Laboratory, U.S. Department of Energy, Oak Ridge, Tennessee, U.S.A.; Hanson, P. J. [Oak Ridge National Laboratory, U.S. Department of Energy, Oak Ridge, Tennessee, U.S.A.; Brice, D. J. [Oak Ridge National Laboratory, U.S. Department of Energy, Oak Ridge, Tennessee, U.S.A.; Phillips, J. R. [Oak Ridge National Laboratory, U.S. Department of Energy, Oak Ridge, Tennessee, U.S.A.; McFarlane, K. J. [Oak Ridge National Laboratory, U.S. Department of Energy, Oak Ridge, Tennessee, U.S.A.; Hobbie, E. A. [Oak Ridge National Laboratory, U.S. Department of Energy, Oak Ridge, Tennessee, U.S.A.; Kolka, R. K. [Oak Ridge National Laboratory, U.S. Department of Energy, Oak Ridge, Tennessee, U.S.A.

2012-01-01

This data set reports the results of physical and chemical analyses of peat core samples from the SPRUCE experimental study plots located in the S1-Bog. On August 13-15, 2012, a team of SPRUCE investigators and collaborators collected core samples of peat in the SPRUCE experimental plots. The goal was to characterize the biological, physical, and chemical characteristics of peat, and how those characteristics changed throughout the depth profile of the bog, prior to the initialization of the SPRUCE experimental warming and CO2 treatments. Cores were collected from 16 experimental plots; samples were collected from the hummock and hollow surfaces to depths of 200-300 cm in defined increments. Three replicate cores were collected from both hummock and hollow locations in each plot. The coring locations within each plot were mapped

15N fractionation in infrared-dark cloud cores

NASA Astrophysics Data System (ADS)

Zeng, S.; Jiménez-Serra, I.; Cosentino, G.; Viti, S.; Barnes, A. T.; Henshaw, J. D.; Caselli, P.; Fontani, F.; Hily-Blant, P.

2017-07-01

Context. Nitrogen is one of the most abundant elements in the Universe and its 14N/15N isotopic ratio has the potential to provide information about the initial environment in which our Sun formed. Recent findings suggest that the solar system may have formed in a massive cluster since the presence of short-lived radioisotopes in meteorites can only be explained by the influence of a supernova. Aims: We seek to determine the 14N/15N ratio towards a sample of cold and dense cores at the initial stages in their evolution. Methods: We observed the J = 1 → 0 transitions of HCN, H13CN, HC15N, HN13C, and H15NC towards a sample of 22 cores in four infrared-dark clouds (IRDCs) which are believed to be the precursors of high-mass stars and star clusters. Assuming LTE and a temperature of 15 K, the column densities of HCN, H13CN, HC15N, HN13C, and H15NC are calculated and their 14N/15N ratio is determined for each core. Results: The 14N/15N ratios measured in our sample of IRDC cores range between 70 and ≥763 in HCN and between 161 and 541 in HNC. These ratios are consistent with the terrestrial atmosphere (TA) and protosolar nebula (PSN) values, and with the ratios measured in low-mass prestellar cores. However, the 14N/15N ratios measured in cores C1, C3, F1, F2, and G2 do not agree with the results from similar studies towards the same cores using nitrogen bearing molecules with nitrile functional group (-CN) and nitrogen hydrides (-NH) although the ratio spread covers a similar range. Conclusions: Relatively low 14N/15N ratios amongst the four-IRDCs were measured in IRDC G which are comparable to those measured in small cosmomaterials and protoplanetary disks. The low average gas density of this cloud suggests that the gas density, rather than the gas temperature, may be the dominant parameter influencing the initial nitrogen isotopic composition in young PSN. The reduced spectra (FITS files) are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/603/A22

Collapse and Fragmentation Models of Tidally Interacting Molecular Cloud Cores. IV. Initial Slow Rotation and Magnetic Field Support

NASA Astrophysics Data System (ADS)

Sigalotti, Leonardo Di G.; Klapp, Jaime

2000-03-01

Fragmentation has long been advocated as the primary mechanism for explaining the observed binary frequency among pre-main-sequence stars and, more recently, for explaining the emerging evidence for binary and multiple protostellar systems. The role of magnetic fields and ambipolar diffusion is essential to understand how dense cloud cores begin dynamic collapse and eventually fragment into protostars. Here we consider new numerical models of the gravitational collapse and fragmentation of slowly rotating molecular cloud cores, including the effects of magnetic support and ambipolar diffusion. The starting point of the evolution is provided by a magnetically stable (subcritical) condensation that results from adding a magnetic field pressure, B2/8π [with the field strength given by the scaling relation B=B0(ρ/ρ0)1/2], to a reference state consisting of a thermally supercritical (α~0.36), slowly rotating (β~0.037), Gaussian cloud core of prolate shape and central density ρ0. The effects of ambipolar diffusion are approximated by allowing the reference field strength B0 to gradually decrease over a timescale of 10 free-fall times. The models also include the effects of tidal interaction due to a gravitational encounter with another protostar, and so they may apply to low-mass star formation within a cluster-forming environment. The results indicate that the magnetic forces delay the onset of dynamic collapse, and hence of fragmentation, by an amount of time that depends on the initial central mass-to-flux ratio. Compared with previous magnetic collapse calculations of rapidly rotating (β=0.12) clouds, lower initial rotation (β~0.037) is seen to result in much shorter delay periods, thus anticipating binary fragmentation. In general, the results show that the models are still susceptible to fragment into binary systems. Intermediate magnetic support (η~0.285) and low tidal forces (τ<~0.201) may lead to final triple or quadruple protostellar systems, while increasing the size of η and τ always results in final binary protostellar cores. The formed binary systems have separations of ~200-350 AU, suggesting that the recently observed peaks around ~90 AU and 215 AU for T Tauri stars may be explained by the collapse and fragmentation of initially slowly rotating magnetic cloud cores with β<~0.04.

From Adoption to Practice: Teacher Perspectives on the Common Core. Findings from a National Survey

ERIC Educational Resources Information Center

Editorial Projects in Education, 2014

2014-01-01

The Common Core State Standards Initiative will enter a critical period during the 2014-15 school year. Several states have recently reversed course on adoption of the mathematics and English/language arts standards, as vocal opposition gains prominence elsewhere. Despite fraying of the two national consortia developing assessments tied to the new…

Changes in the Expertise of ESL Professionals: Knowledge and Action in an Era of New Standards

ERIC Educational Resources Information Center

Valdés, Guadalupe; Kibler, Amanda; Walqui, Aída

2014-01-01

This professional paper builds on the work of TESOL's issue briefs, "Implementing the Common Core State Standards for English Learners: The Changing Role of the ESL Teacher" (February 2013) and Overview of the Common Core State Standards Initiatives for ELLs (March, 2013). It discusses the shifting landscape surrounding the new Common…

Core Curriculum Revision at TCU: How Faculty Created and Are Maintaining the TCU Core Curriculum

ERIC Educational Resources Information Center

McNertney, Edward; Ferrandino, Blaise

2010-01-01

The initiative to revise Texas Christian University's (TCU) general education curriculum was one of the outcomes of an institutional strategic planning process in 2000, the Commission on the Future of TCU. Coincident with this planning process, TCU developed a new institutional mission statement that focused on preparing students for becoming…

Northwest Manufacturing Initiative

DTIC Science & Technology

2012-03-27

crack growth and threshold stress corrosion cracking evaluation. Threshold stress corrosion cracking was done using the rising step load method with...Group Technology methods to establish manufacturing cells for production efficiency, to develop internal Lean Champions, and to implement rapid... different levels, advisory, core, etc. VI. Core steering committee composed of members that have a significant vested interest. Action Item: Draft

Employee Participation in Non-Mandatory Professional Development--The Role of Core Proactive Motivation Processes

ERIC Educational Resources Information Center

Sankey, Kim S.; Machin, M. Anthony

2014-01-01

With a focus on the self-initiated efforts of employees, this study examined a model of core proactive motivation processes for participation in non-mandatory professional development (PD) within a proactive motivation framework using the Self-Determination Theory perspective. A multi-group SEM analysis conducted across 439 academic and general…

How Service and Learning Came Together to Promote "Cura Personalis"

ERIC Educational Resources Information Center

Wright, Ann; Calabrese, Nicki; Henry, Julie

2009-01-01

"Cura personalis" (care of the individual) represents one of the core ideals of all Jesuit colleges and universities. At one urban Jesuit college, faculty members of The School of Education and Human Services and The College of Arts and Sciences initiated a service-learning project in a freshman level pedagogical core course. One goal of the…

What Teachers Should Know about Common Core: A Guide for the Perplexed

ERIC Educational Resources Information Center

Shanahan, Timothy

2015-01-01

In 2010, more than 40 states adopted the Common Core State Standards. Initially, the standards were quickly and easily embraced, but over the past year the standards have become enmeshed in various controversies, raising many questions about how the standards were written and what they include. This article attempts to provide authoritative…

Slope across the Curriculum: Principles and Standards for School Mathematics and Common Core State Standards

ERIC Educational Resources Information Center

Nagle, Courtney; Moore-Russo, Deborah

2014-01-01

This article provides an initial comparison of the Principles and Standards for School Mathematics and the Common Core State Standards for Mathematics by examining the fundamental notion of slope. Each set of standards is analyzed using eleven previously identified conceptualizations of slope. Both sets of standards emphasize Functional Property,…

Common Core State Standards: An Example of Data-Less Decision Making

ERIC Educational Resources Information Center

Tienken, Christopher H., Ed.

2011-01-01

The Common Core State Standards (CCSS) initiative continues to move forward. As of October 2010, 37 states and territories made the CCSS the legal law of their land in terms of the mathematics and language arts curricula used in their public schools. Over 170 organizations, education-related and corporations alike, have pledged their support to…

Answering a Call to Action: Engaging University Faculty on the Common Core State Standards

ERIC Educational Resources Information Center

Alvarado-Santos, Angelita; Case, Jennifer M.; Thompson, Ashleigh; Chertoff, Natalie

2017-01-01

Using various strategies, the City University of New York--a large, public, urban university system--engaged hundreds of faculty across 15 colleges in integrating the Common Core state standards (CCSS) in college coursework. Against the backdrop of a dynamic political climate, this CCSS initiative is described along with findings from a…

Fire performances of foam core particleboards continuously produced in a one-step process

Treesearch

Ali Shalbafan; Mark A. Dietenberger; Johannes Welling

2013-01-01

For further progress of novel foam core particleboards, their fire performance was examined with cone calorimetry tests (ASTM E 1354-11a). Specimens with varying surface layer thicknesses, foam densities (polystyrene foam), and processing temperatures were tested. Using the initially recommended cone irradiance of 35 kW/m2, different flammability...

The Common Core State Standards Initiative: An Event History Analysis of State Adoption

ERIC Educational Resources Information Center

LaVenia, Mark; Cohen-Vogel, Lora; Lang, Laura B.

2015-01-01

Today, with states' near-universal adoption of the Common Core State Standards, the political system has achieved that which was not possible less than 2 decades ago. Just why this is so remains unanswered. Some observers have attributed states' embrace of the standards to the substantial financial incentives that the federal government embedded…

Using Teacher Evaluation Reform and Professional Development to Support Common Core Assessments

ERIC Educational Resources Information Center

Youngs, Peter

2013-01-01

The Common Core State Standards Initiative, in its aim to align diverse state curricula and improve educational outcomes, calls for K-12 teachers in the United States to engage all students in mathematical problem solving along with reading and writing complex text through the use of rigorous academic content. Until recently, most teacher…

The initiation and development of small peat-forming ecosystems adjacent to lakes in the north central Canadian low arctic during the Holocene

NASA Astrophysics Data System (ADS)

Camill, Philip; Umbanhowar, Charles E.; Geiss, Christoph; Edlund, Mark B.; Hobbs, Will O.; Dupont, Allison; Doyle-Capitman, Catherine; Ramos, Matthew

2017-07-01

Small peat-forming ecosystems in arctic landscapes may play a significant role in the regional biogeochemistry of high-latitude systems, yet they are understudied compared to arctic uplands and other major peat-forming regions of the North. We present a new data set of 25 radiocarbon-dated permafrost peat cores sampled around eight low arctic lake sites in northern Manitoba (Canada) to examine the timing of peat initiation and controls on peat accumulation throughout the Holocene. We used macrofossils and charcoal to characterize changes in the plant community and fire, and we explored potential impacts of these local factors, as well as regional climatic change, on rates of C accumulation and C stocks. Peat initiation was variable across and within sites, suggesting the influence of local topography, but 56% of the cores initiated after 3000 B.P. Most cores initiated and remained as drier bog hummock communities, with few vegetation transitions in this landscape. C accumulation was relatively slow and did not appear to be correlated with Holocene-scale climatic variability, but C stocks in this landscape were substantial (mean = 45.4 kg C m-2), potentially accounting for 13.2 Pg C in the Taiga Shield ecozone. To the extent that small peat-forming systems are underrepresented in peatland mapping, soil organic carbon (SOC) stocks may be underestimated in arctic regions. Mean fire severity appeared to be negatively correlated with C accumulation rates. Initiation and accumulation of soil C may respond to both regional and local factors, and substantial lowland soil C stocks have the potential for biogeochemical impacts on adjacent aquatic ecosystems.

Microstructures and performance of CaO-based ceramic cores with different particle size distributions for investment casting

NASA Astrophysics Data System (ADS)

Zhou, P. P.; Wu, G. Q.; Tao, Y.; Cheng, X.; Zhao, J. Q.; Nan, H.

2018-02-01

A series of calcium-based ceramic cores for casting titanium alloy were prepared by mixing different amounts of coarse and fine powders through injection molding. The effects of particle size on the microstructures and properties of the ceramic cores were investigated using quantitative and statistical analysis methods. It is found that the shrinkage and room-temperature strength of the ceramic cores were enhanced as increasing the contents of fine particles. Moreover, the creep resistance of the ceramic cores increased initially and then decreased. The increase in the fine particle content of the cores reduced the number and mean diameter of pores after sintering. The grain boundary density decreased firstly and then increased. The flexural strength of the ceramic cores at room temperature decreased with increasing porosity of ceramic cores, whereas the creep resistance increased with decreasing grain boundary density. A core exhibiting the optimal property was obtained when mixing 65 wt% of coarse powders (75-150 μm) and 35 wt% of fine powders (25-48 μm).

Posttest REALP4 analysis of LOFT experiment L1-3A

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, J.R.; Holmstrom, H.L.O.

This report presents selected results of posttest RELAP4 modeling of LOFT loss-of-coolant experiment L1-3A, a double-ended isothermal cold leg break with lower plenum emergency core coolant injection. Comparisons are presented between the pretest prediction, the posttest analysis, and the experimental data. It is concluded that pressurizer modeling is important for accurately predicting system behavior during the initial portion of saturated blowdown. Using measured initial conditions rather than nominal specified initial conditions did not influence the system model results significantly. Using finer nodalization in the reactor vessel improved the prediction of the system pressure history by minimizing steam condensation effects. Unequalmore » steam condensation between the downcomer and core volumes appear to cause the manometer oscillations observed in both the pretest and posttest RELAP4 analysis.« less

Re-refinement of the spliceosomal U4 snRNP core-domain structure

PubMed Central

Li, Jade; Leung, Adelaine K.; Kondo, Yasushi; Oubridge, Chris; Nagai, Kiyoshi

2016-01-01

The core domain of small nuclear ribonucleoprotein (snRNP), comprised of a ring of seven paralogous proteins bound around a single-stranded RNA sequence, functions as the assembly nucleus in the maturation of U1, U2, U4 and U5 spliceosomal snRNPs. The structure of the human U4 snRNP core domain was initially solved at 3.6 Å resolution by experimental phasing using data with tetartohedral twinning. Molecular replacement from this model followed by density modification using untwinned data recently led to a structure of the minimal U1 snRNP at 3.3 Å resolution. With the latter structure providing a search model for molecular replacement, the U4 core-domain structure has now been re-refined. The U4 Sm site-sequence AAUUUUU has been shown to bind to the seven Sm proteins SmF–SmE–SmG–SmD3–SmB–SmD1–SmD2 in an identical manner as the U1 Sm-site sequence AAUUUGU, except in SmD1 where the bound U replaces G. The progression from the initial to the re-refined structure exemplifies a tortuous route to accuracy: where well diffracting crystals of complex assemblies are initially unavailable, the early model errors are rectified by exploiting preliminary interpretations in further experiments involving homologous structures. New insights are obtained from the more accurate model. PMID:26894541

Characterizing Mobile/Less-Mobile Porosity and Solute Exchange in Dual-Domain Media Using Tracer Experiments and Electrical Measurements in a Hassler-Type Core Holder

NASA Astrophysics Data System (ADS)

Falzone, S.; Slater, L. D.; Day-Lewis, F. D.; Parker, B. L.; Keating, K.; Robinson, J.

2017-12-01

Mass transfer is the process by which solute is retained in less-mobile porosity domains, and later released into the mobile porosity domain. This process is often responsible for the slow arrival and gradual release of contaminants and solute tracers. Recent studies have outlined methods using dual-domain mass transfer (DDMT) models for characterizing this phenomenon. These models use the non-linear relationship of bulk (σb) and fluid (σf) conductivity, collected from electrical methods during tracer experiments, to characterize the less-mobile/mobile porosity ratio (β) and the mass-transfer rate coefficient (α). DDMT models use the hysteretic σb-σf relationship observed while solute tracers are injected and then flushed from a sample media. Due to limitations in observing the hysteretic σb-σf relationship, this method has not been used to characterize low permeability samples. We have developed an experimental method for testing porous rock cores that allows us to develop a fundamental understanding of contaminant storage and release in consolidated rock. We test the approach on cores from sedimentary rock sites where mass transfer is expected to occur between hydraulically connected fractures and the adjacent low permeability rock matrix. Our method uses a Hassler-type core holder, designed to apply confining pressure around the outside of a sample core, which hydraulically isolates the sample core, allowing water to be injected into it at increased pressures. The experimental apparatus was also designed to measure σb with spectral induced polarization (SIP) measurements, and σf from a sampling port located at the center of the core. Cores were initially saturated with a solution with high electrical conductivity ( 80000 μS/cm). DI water was then injected into the cores at elevated pressures (>60 psi) and the saturating solution was flushed from the cores, in order to generate flow rates fast enough to capture the non-linear σb-σf relationship expected when DDMT occurs. Our initial results demonstrate the existence of a non-linear σb-σf relationship indicative of DDMT for a tight sandstone core from a contaminated fractured rock site. Integrating the electrical results with known physical characteristics of the cores, we are able to quantify the mass transfer characteristics of the cores.

Operational Initiative in Theory and Doctrine

DTIC Science & Technology

2015-05-21

1984 Paret translation of On War uses the term initiative with far more frequency than the original German text ; given that Paret contextually...logical evolution of thought throughout doctrine, from core texts and dominant military theory prior to 1905 through the current catalogued system...Unfortunately, no such cohesive map currently exists; rather, military theorists have charted the terrain of initiative piecemeal. This section seeks to

Financial Literacy: Getting beyond the Markets

ERIC Educational Resources Information Center

Stanford, Jim

2010-01-01

Recently, several Canadian provinces have added financial literacy into core curriculum for high school students, and in his 2009 budget, federal Finance Minister Jim Flaherty announced the creation of a Task Force to evaluate current financial literacy initiatives. Typically, these initiatives focus on "individual responsibility",…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romero, Antonio; Oweis, Salah; Chagnon, Guy

An electrochemical cell having a spiral winding around a central core, wherein the central core is provided with longitudinal grooves on its outer surface to facilitate electrolyte filing and accommodate overpressure. The core itself improves dissipation of heat generated along the center of the cell, and the hollow core design allows the cell core to have a larger radius, permitting the "jelly roll" winding to begin at a larger radius and thereby facilitate the initial turns of the winding by decreasing the amount of bending required of the electrode laminate at the beginning of the winding operation. The hollow coremore » also provides mechanical support end-to-end. A pair of washers are used at each end of the cell to sandwich current collection tabs in a manner that improves electrical and thermal conductivity while also providing structural integrity.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, D. H.; Reigel, M. M.

A full-scale formed core sampler was designed and functionally tested for use in the Saltstone Disposal Facility (SDF). Savannah River National Laboratory (SRNL) was requested to compare properties of the formed core samples and core drilled samples taken from adjacent areas in the full-scale sampler. While several physical properties were evaluated, the primary property of interest was hydraulic conductivity. Differences in hydraulic conductivity between the samples from the formed core sampler and those representing the bulk material were noted with respect to the initial handling and storage of the samples. Due to testing conditions, the site port samples were exposedmore » to uncontrolled temperature and humidity conditions prior to testing whereas the formed core samples were kept in sealed containers with minimal exposure to an uncontrolled environment prior to testing. Based on the results of the testing, no significant differences in porosity or density were found between the formed core samples and those representing the bulk material in the test stand.« less

Deflection Measurements of a Thermally Simulated Nuclear Core Using a High-Resolution CCD-Camera

NASA Technical Reports Server (NTRS)

Stanojev, B. J.; Houts, M.

2004-01-01

Space fission systems under consideration for near-term missions all use compact. fast-spectrum reactor cores. Reactor dimensional change with increasing temperature, which affects neutron leakage. is the dominant source of reactivity feedback in these systems. Accurately measuring core dimensional changes during realistic non-nuclear testing is therefore necessary in predicting the system nuclear equivalent behavior. This paper discusses one key technique being evaluated for measuring such changes. The proposed technique is to use a Charged Couple Device (CCD) sensor to obtain deformation readings of electrically heated prototypic reactor core geometry. This paper introduces a technique by which a single high spatial resolution CCD camera is used to measure core deformation in Real-Time (RT). Initial system checkout results are presented along with a discussion on how additional cameras could be used to achieve a three- dimensional deformation profile of the core during test.

Core Vessel Insert Handling Robot for the Spallation Neutron Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graves, Van B; Dayton, Michael J

2011-01-01

The Spallation Neutron Source provides the world's most intense pulsed neutron beams for scientific research and industrial development. Its eighteen neutron beam lines will eventually support up to twenty-four simultaneous experiments. Each beam line consists of various optical components which guide the neutrons to a particular instrument. The optical components nearest the neutron moderators are the core vessel inserts. Located approximately 9 m below the high bay floor, these inserts are bolted to the core vessel chamber and are part of the vacuum boundary. They are in a highly radioactive environment and must periodically be replaced. During initial SNS construction,more » four of the beam lines received Core Vessel Insert plugs rather than functional inserts. Remote replacement of the first Core Vessel Insert plug was recently completed using several pieces of custom-designed tooling, including a highly complicated Core Vessel Insert Robot. The design of this tool are discussed.« less

Experiments pertaining to the formation and equilibration of planetary cores

NASA Technical Reports Server (NTRS)

Jeanloz, Raymond; Knittle, Elise; Williams, Quentin

1987-01-01

The phase diagram of FeO was experimentally determined to pressures of 155 GPa and temperatures of 4000 K using shock wave and diamond-cell techniques. Researchers discovered a metallic phase of FeO at pressures greater than 70 GPa and temperatures exceeding 1000 K. The metallization of FeO at high pressures implies that oxygen can be present as the light alloying element of the Earth's outer core, in accord with the geochemical predictions of Ringwood. The high pressures necessry for this metallization suggest that the core has acquired its composition well after the initial stages of the Earth's accretion. The core forming alloy can react chemically with oxides such as those forming the mantle. The core and mantle may never have reached complete chemical equilibrium, however. If this is the case, the core-mantle boundary is likely to be a zone of active chemical reactions.

Interrelating the breakage and composition of mined and drill core coal

NASA Astrophysics Data System (ADS)

Wilson, Terril Edward

Particle size distribution of coal is important if the coal is to be beneficiated, or if a coal sales contract includes particle size specifications. An exploration bore core sample of coal ought to be reduced from its original cylindrical form to a particle size distribution and particle composition that reflects, insofar as possible, a process stream of raw coal it represents. Often, coal cores are reduced with a laboratory crushing machine, the product of which does not match the raw coal size distribution. This study proceeds from work in coal bore core reduction by Australian investigators. In this study, as differentiated from the Australian work, drop-shatter impact breakage followed by dry batch tumbling in steel cylinder rotated about its transverse axis are employed to characterize the core material in terms of first-order and zeroth-order breakage rate constants, which are indices of the propensity of the coal to degrade during excavation and handling. Initial drop-shatter and dry tumbling calibrations were done with synthetic cores composed of controlled low-strength concrete incorporating fly ash (as a partial substitute for Portland cement) in order to reduce material variables and conserve difficult-to-obtain coal cores. Cores of three different coalbeds--Illinois No. 6, Upper Freeport, and Pocahontas No. 5 were subjected to drop-shatter and dry batch tumbling tests to determine breakage response. First-order breakage, characterized by a first-order breakage index for each coal, occurred in the drop-shatter tests. First- and zeroth-order breakage occurred in dry batch tumbling; disappearance of coarse particles and creation of fine particles occurred in a systematic way that could be represented mathematically. Certain of the coal cores available for testing were dry and friable. Comparison of coal preparation plant feed with a crushed bore core and a bore core prepared by drop-shatter and tumbling (all from the same Illinois No.6 coal mining property) indicated that the size distribution and size fraction composition of the drop-shattered/tumbled core more closely resembled the plant feed than the crushed core. An attempt to determine breakage parameters (to allow use of selection and breakage functions and population balance models in the description of bore core size reduction) was initiated. Rank determination of the three coal types was done, indicating that higher rank associates with higher breakage propensity. The two step procedure of drop-shatter and dry batch tumbling simulates the first-order (volume breakage) and zeroth-order (abrasion of particle surfaces) that occur in excavation and handling operations, and is appropriate for drill core reduction prior to laboratory analysis.

Numerical models of the Earth’s thermal history: Effects of inner-core solidification and core potassium

NASA Astrophysics Data System (ADS)

Butler, S. L.; Peltier, W. R.; Costin, S. O.

2005-09-01

Recently there has been renewed interest in the evolution of the inner core and in the possibility that radioactive potassium might be found in significant quantities in the core. The arguments for core potassium come from considerations of the age of the inner core and the energy required to sustain the geodynamo [Nimmo, F., Price, G.D., Brodholt, J., Gubbins, D., 2004. The influence of potassium on core and geodynamo evolution. Geophys. J. Int. 156, 363-376; Labrosse, S., Poirier, J.-P., Le Mouël, J.-L., 2001. The age of the inner core. Earth Planet Sci. Lett. 190, 111-123; Labrosse, S., 2003. Thermal and magnetic evolution of the Earth's core. Phys. Earth Planet Int. 140, 127-143; Buffett, B.A., 2003. The thermal state of Earth's core. Science 299, 1675-1677] and from new high pressure physics analyses [Lee, K., Jeanloz, R., 2003. High-pressure alloying of potassium and iron: radioactivity in the Earth's core? Geophys. Res. Lett. 30 (23); Murthy, V.M., van Westrenen, W., Fei, Y.W., 2003. Experimental evidence that potassium is a substantial radioactive heat source in planetary cores. Nature 423, 163-165; Gessmann, C.K., Wood, B.J., 2002. Potassium in the Earth's core? Earth Planet Sci. Lett. 200, 63-78]. The Earth's core is also located at the lower boundary of the convecting mantle and the presence of radioactive heat sources in the core will affect the flux of heat between these two regions and will, as a result, have a significant impact on the Earth's thermal history. In this paper, we present Earth thermal history simulations in which we calculate fluid flow in a spherical shell representing the mantle, coupled with a core of a given heat capacity with varying degrees of internal heating in the form of K40 and varying initial core temperatures. The mantle model includes the effects of the temperature dependence of viscosity, decaying radioactive heat sources, and mantle phase transitions. The core model includes the thermal effects of inner core solidification and we present models for which the final size of the inner core is the same that for the present-day Earth. We compare the results of simulations with and without the effects of inner core solidification and we compare the results of the numerical model with those of a parameterized model. Models with concentrations of potassium in the core of roughly 600 ppm best satisfy the present-day surface heat flow constraint; however, the core temperatures in these models are somewhat high. In addition, we find that models with lesser degrees of heating in the core can also satisfy the surface heat flow constraint provided that the mantle is in a particularly active state. Our models predict a relatively young inner core with the greatest age being 1756 Ma. We demonstrate that models with high core temperatures in the latter part of simulations result in high CMB heat flows which lead to predictions of young inner cores. For fixed initial core temperatures, this leads to a slight decrease in the predicted age of the inner core with increasing concentration of radioactive elements in the core.

Method of manufacturing positive nickel hydroxide electrodes

DOEpatents

Gutjahr, M.A.; Schmid, R.; Beccu, K.D.

1975-12-16

A method of manufacturing a positive nickel hydroxide electrode is discussed. A highly porous core structure of organic material having a fibrous or reticular texture is uniformly coated with nickel powder and then subjected to a thermal treatment which provides sintering of the powder coating and removal of the organic core material. A consolidated, porous nickel support structure is thus produced which has substantially the same texture and porosity as the initial core structure. To provide the positive electrode including the active mass, nickel hydroxide is deposited in the pores of the nickel support structure.

Statistical Constraints from Siderophile Elements on Earth's Accretion, Differentiation, and Initial Core Stratification

NASA Astrophysics Data System (ADS)

O'Rourke, J. G.; Stevenson, D. J.

2015-12-01

Abundances of siderophile elements in the primitive mantle constrain the conditions of Earth's core/mantle differentiation. Core growth occurred as Earth accreted from collisions between planetesimals and larger embryos of unknown original provenance, so geochemistry is directly related to the overall dynamics of Solar System formation. Recent studies claim that only certain conditions of equilibration (pressure, temperature, and oxygen fugacity) during core formation can reproduce the available data. Typical analyses, however, only consider the effects of varying a few out of tens of free parameters in continuous core formation models. Here we describe the Markov chain Monte Carlo method, which simultaneously incorporates the large uncertainties on Earth's composition and the parameterizations that describe elemental partitioning between metal and silicate. This Bayesian technique is vastly more computationally efficient than a simple grid search and is well suited to models of planetary accretion that involve a plethora of variables. In contrast to previous work, we find that analyses of siderophile elements alone cannot yield a unique scenario for Earth's accretion. Our models predict a wide range of possible light element contents for the core, encompassing all combinations permitted by seismology and mineral physics. Specifically, we are agnostic between silicon and oxygen as the dominant light element, and the addition of carbon or sulfur is also permissible but not well constrained. Redox conditions may have remained roughly constant during Earth's accretion or relatively oxygen-rich material could have been incorporated before reduced embryos. Pressures and temperatures of equilibration, likewise, may only increase slowly throughout accretion. Therefore, we do not necessarily expect a thick (>500 km), compositionally stratified layer that is stable against convection to develop at the top of the core of Earth (or, by analogy, Venus). A thinner stable layer might inhibit the initialization of the dynamo.

ACOUSTIC SIGNATURES OF THE HELIUM CORE FLASH

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bildsten, Lars; Paxton, Bill; Moore, Kevin

2012-01-15

All evolved stars with masses M {approx}< 2 M{sub Sun} undergo an initiating off-center helium core flash in their M{sub c} Almost-Equal-To 0.48 M{sub Sun} He core as they ascend the red giant branch (RGB). This off-center flash is the first of a few successive helium shell subflashes that remove the core electron degeneracy over 2 Myr, converting the object into a He-burning star. Though characterized by Thomas over 40 years ago, this core flash phase has yet to be observationally probed. Using the Modules for Experiments in Stellar Astrophysics (MESA) code, we show that red giant asteroseismology enabled bymore » space-based photometry (i.e., Kepler and CoRoT) can probe these stars during the flash. The rapid ({approx}< 10{sup 5} yr) contraction of the red giant envelope after the initiating flash dramatically improves the coupling of the p-modes to the core g-modes, making the detection of l = 1 mixed modes possible for these 2 Myr. This duration implies that 1 in 35 stars near the red clump in the H-R diagram will be in their core flash phase. During this time, the star has a g-mode period spacing of {Delta}P{sub g} Almost-Equal-To 70-100 s, lower than the {Delta}P{sub g} Almost-Equal-To 250 s of He-burning stars in the red clump, but higher than the RGB stars at the same luminosity. This places them in an underpopulated part of the large frequency spacing ({Delta}{nu}) versus {Delta}P{sub g} diagram that should ease their identification among the thousands of observed red giants.« less

Let History Not Repeat Itself: Overcoming Obstacles to the Common Core's Success. ES Select

ERIC Educational Resources Information Center

Chubb, John

2012-01-01

The Common Core State Standards project is the latest in a series of efforts to improve the academic success of American students. Forty-five states and the District of Columbia have endorsed new academic benchmarks that substantially raise the bar for achievement in English and mathematics. Aiming at a deeper form of learning, the initiative is a…

Growing Awareness, Growing Support: Teacher and Voter Understanding of the Common Core State Standards & Assessments

ERIC Educational Resources Information Center

Achieve, Inc., 2012

2012-01-01

Since June 2010, 46 states and Washington DC have chosen to adopt the Common Core State Standards (CCSS)--K-12 standards in mathematics and English language arts/literacy developed through a multi-state initiative led by the National Governors Association and the Council of Chief State School Officers. As implementation of the standards is…

77 FR 66436 - Hardwood and Decorative Plywood From the People's Republic of China: Initiation of Antidumping...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-05

... Investigation Hardwood and decorative plywood is a panel composed of an assembly of two or more layers or plies of wood veneer(s) in combination with a core. The several layers, along with the core, are glued or otherwise bonded together to form a finished product. A hardwood and decorative plywood panel can be...

Structural and functional aspects of winged-helix domains at the core of transcription initiation complexes.

PubMed

Teichmann, Martin; Dumay-Odelot, Hélène; Fribourg, Sébastien

2012-01-01

The winged helix (WH) domain is found in core components of transcription systems in eukaryotes and prokaryotes. It represents a sub-class of the helix-turn-helix motif. The WH domain participates in establishing protein-DNA and protein-protein-interactions. Here, we discuss possible explanations for the enrichment of this motif in transcription systems.

Bioprinting Using Mechanically Robust Core-Shell Cell-Laden Hydrogel Strands.

PubMed

Mistry, Pritesh; Aied, Ahmed; Alexander, Morgan; Shakesheff, Kevin; Bennett, Andrew; Yang, Jing

2017-06-01

The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combination of optimal biological and mechanical properties in bioprinted constructs. Here, a novel bioprinting method that utilizes core-shell cell-laden strands with a mechanically robust shell and an extracellular matrix-like core has been developed. Cells encapsulated in the strands demonstrate high cell viability and tissue-like functions during cultivation. This process of bioprinting using core-shell strands with optimal biochemical and biomechanical properties represents a new strategy for fabricating functional human tissues and organs. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Development of a core competency model for the master of public health degree.

PubMed

Calhoun, Judith G; Ramiah, Kalpana; Weist, Elizabeth McGean; Shortell, Stephen M

2008-09-01

Core competencies have been used to redefine curricula across the major health professions in recent decades. In 2006, the Association of Schools of Public Health identified core competencies for the master of public health degree in graduate schools and programs of public health. We provide an overview of the model development process and a listing of 12 core domains and 119 competencies that can serve as a resource for faculty and students for enhancing the quality and accountability of graduate public health education and training. The primary vision for the initiative is the graduation of professionals who are more fully prepared for the many challenges and opportunities in public health in the forthcoming decade.

How do binary separations depend on cloud initial conditions?

NASA Astrophysics Data System (ADS)

Sterzik, M. F.; Durisen, R. H.; Zinnecker, H.

2003-11-01

We explore the consequences of a star formation scenario in which the isothermal collapse of a rotating, star-forming core is followed by prompt fragmentation into a cluster containing a small number (N <~ 10) of protostars and/or substellar objects. The subsequent evolution of the cluster is assumed to be dominated by dynamical interactions among cluster members, and this establishes the final properties of the binary and multiple systems. The characteristic scale of the fragmenting core is determined by the cloud initial conditions (such as temperature, angular momentum and mass), and we are able to relate the separation distributions of the final binary population to the properties of the star-forming core. Because the fragmentation scale immediately after the isothermal collapse is typically a factor of 3-10 too large, we conjecture that fragmentation into small clusters followed by dynamical evolution is required to account for the observed binary separation distributions. Differences in the environmental properties of the cores are expected to imprint differences on the characteristic dimensions of the binary systems they form. Recent observations of hierarchical systems, differences in binary characteristics among star forming regions and systematic variations in binary properties with primary mass can be interpreted in the context of this scenario.

The Alzheimer’s Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans

PubMed Central

Kang, Ju-Hee; Korecka, Magdalena; Figurski, Michal J.; Toledo, Jon B.; Blennow, Kaj; Zetterberg, Henrik; Waligorska, Teresa; Brylska, Magdalena; Fields, Leona; Shah, Nirali; Soares, Holly; Dean, Robert A.; Vanderstichele, Hugo; Petersen, Ronald C.; Aisen, Paul S.; Saykin, Andrew J.; Weiner, Michael W.; Trojanowski, John Q.; Shaw, Leslie M.

2016-01-01

Introduction We describe Alzheimer’s Disease Neuroimaging Initiative (ADNI) Biomarker Core progress including: the Biobank; cerebrospinal fluid (CSF) amyloid beta (Aβ1–42), t-tau, and p-tau181 analytical performance, definition of Alzheimer’s disease (AD) profile for plaque, and tangle burden detection and increased risk for progression to AD; AD disease heterogeneity; progress in standardization; and new studies using ADNI biofluids. Methods Review publications authored or coauthored by ADNI Biomarker core faculty and selected non-ADNI studies to deepen the understanding and interpretation of CSF Aβ1–42, t-tau, and p-tau181 data. Results CSFAD biomarker measurements with the qualified AlzBio3 immunoassay detects neuropathologic AD hallmarks in preclinical and prodromal disease stages, based on CSF studies in non-ADNI living subjects followed by the autopsy confirmation of AD. Collaboration across ADNI cores generated the temporal ordering model of AD biomarkers varying across individuals because of genetic/environmental factors that increase/decrease resilience to AD pathologies. Discussion Further studies will refine this model and enable the use of biomarkers studied in ADNI clinically and in disease-modifying therapeutic trials. PMID:26194312

A mixed helium-oxygen shell in some core-collapse supernova progenitors

NASA Astrophysics Data System (ADS)

Gofman, Roni Anna; Gilkis, Avishai; Soker, Noam

2018-04-01

We evolve models of rotating massive stars up to the stage of iron core collapse using the MESA code and find a shell with a mixed composition of primarily helium and oxygen in some cases. In the parameter space of initial masses of 13-40M⊙ and initial rotation velocities of 0-450 kms-1 that we investigate, we find a mixed helium-oxygen (He-O) shell with a significant total He-O mass and with a helium to oxygen mass ratio in the range of 0.5-2 only for a small fraction of the models. While the shell formation due to mixing is instigated by rotation, the pre-collapse rotation rate is not very high. The fraction of models with a shell of He-O composition required for an energetic collapse-induced thermonuclear explosion is small, as is the fraction of models with high specific angular momentum, which can aid the thermonuclear explosion by retarding the collapse. Our results suggest that the collapse-induced thermonuclear explosion mechanism that was revisited recently can account for at most a small fraction of core-collapse supernovae. The presence of such a mixed He-O shell still might have some implications for core-collapse supernovae, such as some nucleosynthesis processes when jets are present, or might result in peculiar sub-luminous core-collapse supernovae.

TMI-2 (Three Mile Island Unit 2) core region defueling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodabaugh, J.M.; Cowser, D.K.

1988-01-01

In July of 1982, a video camera was inserted into the Three Mile Island Unit 2 reactor vessel providing the first visual evidence of core damage. This inspection, and numerous subsequent data acquisition tasks, revealed a central void /approx/1.5 m (5 ft) deep. This void region was surrounded by partial length fuel assemblies and ringed on the periphery by /approx/40 full-length, but partial cross-section, fuel assemblies. All of the original 177 fuel assemblies exhibited signs of damage. The bottom of the void cavity was covered with a bed of granular rubble, fuel assembly upper end fittings, control rod spiders, fuelmore » rod fragments, and fuel pellets. It was obvious that the normal plant refueling system not suitable for removing the damaged core. A new system of defueling tools and equipment was necessary to perform this task. Design of the new system was started immediately, followed by >1 yr of fabrication. Delivery and checkout of the defueling system occurred in mid-1985. Actual defueling was initiated in late 1985 with removal of the debris bed at the bottom of the core void. Obstructions to the debris, such as end fittings and fuel rod fragments ere removed first; then /approx/23,000 kg (50,000lb) of granular debris was quickly loaded into canisters. Core region defueling was completed in late 1987, /approx/2 yr after it was initiated.« less

A mixed helium-oxygen shell in some core-collapse supernova progenitors

NASA Astrophysics Data System (ADS)

Gofman, Roni Anna; Gilkis, Avishai; Soker, Noam

2018-07-01

We evolve models of rotating massive stars up to the stage of iron core collapse using the MESA code and find a shell with a mixed composition of primarily helium and oxygen in some cases. In the parameter space of initial masses of 13-40 M⊙ and initial rotation velocities of 0-450 km s-1 that we investigate, we find a mixed helium-oxygen (He-O) shell with a significant total He-O mass and with a helium to oxygen mass ratio in the range of 0.5-2 only for a small fraction of the models. While the shell formation due to mixing is instigated by rotation, the pre-collapse rotation rate is not very high. The fraction of models with a shell of He-O composition required for an energetic collapse-induced thermonuclear explosion is small, as is the fraction of models with high specific angular momentum, which can aid the thermonuclear explosion by retarding the collapse. Our results suggest that the collapse-induced thermonuclear explosion mechanism that was revisited recently can account for at most a small fraction of core-collapse supernovae. The presence of such a mixed He-O shell still might have some implications for core-collapse supernovae, such as some nucleosynthesis processes when jets are present, or might result in peculiar sub-luminous core-collapse supernovae.

Initiation locations of lightning flashes relative to radar reflectivity in four small Florida thunderstorms

NASA Astrophysics Data System (ADS)

Karunarathna, Nadeeka; Marshall, Thomas C.; Karunarathne, Sumedhe; Stolzenburg, Maribeth

2017-06-01

This study examines initiation locations of intracloud (IC) and cloud-to-ground (CG) lightning near Kennedy Space Center, Florida, on 1 day. One unicellular and two multicellular thunderstorms occurred over land, and one multicellular storm was 30 km offshore. The storm over ocean was visible on radar 47-51 min before its first flash (of 17 total); first echoes in the storms over land were 23, 12, and 16 min prior to the first flashes (of 34, 16, and 9 total). Initiation points of 66 flashes were identified using the first initial breakdown (IB) pulse location from electric field change measurements or a VHF source coincident with the first IB pulse; 10 ICs occurred without enough data to similarly locate the initiation. All but 2 of 35 flashes that initiated as negative CGs began below 6.8 km altitude; two higher CG initiations (7.1-7.5 km) were the first CGs in two storms. Initiations of 21 normal ICs occurred above 7.9 km, 6 late stage ICs initiated at 5.5-7.5 km, and 4 hybrid IC-CG flashes initiated as ICs at 6.6-8.1 km. Initiation locations were tightly clustered in small regions of each cell. Over land, early and mature stage flashes initiated within 2 × 2 km in each cell, or about 10-25% of the midlevel reflectivity coverage. One cell over ocean had initiations within 6 × 5 km, less than 30% of its reflectivity area. The IC initiations generally occurred above reflectivity cores, in 15-35 dBZ, and CG initiations were in 30-45 dBZ beside or atop cores.

Rehabilitation, Replacement and Redesign of the Nation's Water and Wastewater Infrastructure as a Valuable Adaptation Opportunity

EPA Science Inventory

In support of the Agency's Sustainable Water Infrastructure Initiative, EPA's Office of Research and Develpment initiated the Aging Water Infrastructure Research Program in 2007. The program, with its core focus on the support of strategic asset management, is designed to facili...

Digital Initiatives and Metadata Use in Thailand

ERIC Educational Resources Information Center

SuKantarat, Wichada

2008-01-01

Purpose: This paper aims to provide information about various digital initiatives in libraries in Thailand and especially use of Dublin Core metadata in cataloguing digitized objects in academic and government digital databases. Design/methodology/approach: The author began researching metadata use in Thailand in 2003 and 2004 while on sabbatical…

Mapping the core mass function to the initial mass function

NASA Astrophysics Data System (ADS)

Guszejnov, Dávid; Hopkins, Philip F.

2015-07-01

It has been shown that fragmentation within self-gravitating, turbulent molecular clouds (`turbulent fragmentation') can naturally explain the observed properties of protostellar cores, including the core mass function (CMF). Here, we extend recently developed analytic models for turbulent fragmentation to follow the time-dependent hierarchical fragmentation of self-gravitating cores, until they reach effectively infinite density (and form stars). We show that turbulent fragmentation robustly predicts two key features of the initial mass function (IMF). First, a high-mass power-law scaling very close to the Salpeter slope, which is a generic consequence of the scale-free nature of turbulence and self-gravity. We predict the IMF slope (-2.3) is slightly steeper than the CMF slope (-2.1), owing to the slower collapse and easier fragmentation of large cores. Secondly, a turnover mass, which is set by a combination of the CMF turnover mass (a couple solar masses, determined by the `sonic scale' of galactic turbulence, and so weakly dependent on galaxy properties), and the equation of state (EOS). A `soft' EOS with polytropic index γ < 1.0 predicts that the IMF slope becomes `shallow' below the sonic scale, but fails to produce the full turnover observed. An EOS, which becomes `stiff' at sufficiently low surface densities Σgas ˜ 5000 M⊙ pc-2, and/or models, where each collapsing core is able to heat and effectively stiffen the EOS of a modest mass (˜0.02 M⊙) of surrounding gas, are able to reproduce the observed turnover. Such features are likely a consequence of more detailed chemistry and radiative feedback.

Initial results from geophysical surveys and shallow coring of the Northeast Greenland Ice Stream (NEGIS)

NASA Astrophysics Data System (ADS)

Vallelonga, P.; Christianson, K.; Alley, R. B.; Anandakrishnan, S.; Christian, J. E. M.; Dahl-Jensen, D.; Gkinis, V.; Holme, C.; Jacobel, R. W.; Karlsson, N. B.; Keisling, B. A.; Kipfstuhl, S.; Kjær, H. A.; Kristensen, M. E. L.; Muto, A.; Peters, L. E.; Popp, T.; Riverman, K. L.; Svensson, A. M.; Tibuleac, C.; Vinther, B. M.; Weng, Y.; Winstrup, M.

2014-07-01

The Northeast Greenland Ice Stream (NEGIS) is the sole interior Greenlandic ice stream. Fast flow initiates near the summit dome, and the ice stream terminates approximately 1000 km downstream in three large outlet glaciers that calve into the Greenland Sea. To better understand this important system, in the summer of 2012 we drilled a 67 m firn core and conducted ground-based radio-echo sounding (RES) and active-source seismic surveys at a site approximately 150 km downstream from the onset of streaming flow (NEGIS firn core, 75°37.61' N, 35°56.49' W). The site is representative of the upper part of the ice stream, while also being in a crevasse-free area for safe surface operations. Annual cycles were observed for insoluble dust, sodium and ammonium concentrations and for electrolytic conductivity, allowing a seasonally resolved chronology covering the past 400 yr. Annual layer thicknesses averaged 0.11 m ice equivalent (i.e.) for the period 1607-2011, although accumulation varied between 0.08 and 0.14 m i.e., likely due to flow-related changes in surface topography. Tracing of RES layers from the NGRIP (North Greenland Ice Core Project) ice core site shows that the ice at NEGIS preserves a climatic record of at least the past 51 kyr. We demonstrate that deep ice core drilling in this location can provide a reliable Holocene and late-glacial climate record, as well as helping to constrain the past dynamics and ice-lithosphere interactions of the Greenland Ice Sheet.

Extended Fenske-Hall LCAO MO calculations of core-level shifts in solid P compounds

NASA Astrophysics Data System (ADS)

Franke, R.; Chassé, T.; Reinhold, J.; Streubel, P.; Szargan, R.

1997-08-01

Extended Fenske-Hall LCAO-MO ΔSCF calculations on solids modelled as H-pseudoatom saturated clusters are reported. The computational results verify the experimentally obtained initial-state (effective atomic charges, Madelung potential) and relaxation-energy contributions to the XPS phosphorus core-level binding energy shifts measured in Na 3PO 3S, Na 3PO 4, Na 2PO 3F and NH 4PF 6 in reference to red phosphorus. It is shown that the different initial-state contributions observed in the studied phosphates are determined by local and nonlocal terms while the relaxation-energy contributions are mainly dependent on the nature of the nearest neighbors of the phosphorus atom.

Role of cleavage at the core-E1 junction of hepatitis C virus polyprotein in viral morphogenesis.

PubMed

Pène, Véronique; Lemasson, Matthieu; Harper, Francis; Pierron, Gérard; Rosenberg, Arielle R

2017-01-01

In hepatitis C virus (HCV) polyprotein sequence, core protein terminates with E1 envelope signal peptide. Cleavage by signal peptidase (SP) separates E1 from the complete form of core protein, anchored in the endoplasmic reticulum (ER) membrane by the signal peptide. Subsequent cleavage of the signal peptide by signal-peptide peptidase (SPP) releases the mature form of core protein, which preferentially relocates to lipid droplets. Both of these cleavages are required for the HCV infectious cycle, supporting the idea that HCV assembly begins at the surface of lipid droplets, yet SPP-catalyzed cleavage is dispensable for initiation of budding in the ER. Here we have addressed at what step(s) of the HCV infectious cycle SP-catalyzed cleavage at the core-E1 junction is required. Taking advantage of the sole system that has allowed visualization of HCV budding events in the ER lumen of mammalian cells, we showed that, unexpectedly, mutations abolishing this cleavage did not prevent but instead tended to promote the initiation of viral budding. Moreover, even though no viral particles were released from Huh-7 cells transfected with a full-length HCV genome bearing these mutations, intracellular viral particles containing core protein protected by a membrane envelope were formed. These were visualized by electron microscopy as capsid-containing particles with a diameter of about 70 nm and 40 nm before and after delipidation, respectively, comparable to intracellular wild-type particle precursors except that they were non-infectious. Thus, our results show that SP-catalyzed cleavage is dispensable for HCV budding per se, but is required for the viral particles to acquire their infectivity and secretion. These data support the idea that HCV assembly occurs in concert with budding at the ER membrane. Furthermore, capsid-containing particles did not accumulate in the absence of SP-catalyzed cleavage, suggesting the quality of newly formed viral particles is controlled before secretion.

Role of cleavage at the core-E1 junction of hepatitis C virus polyprotein in viral morphogenesis

PubMed Central

Pène, Véronique; Lemasson, Matthieu; Harper, Francis; Pierron, Gérard; Rosenberg, Arielle R.

2017-01-01

In hepatitis C virus (HCV) polyprotein sequence, core protein terminates with E1 envelope signal peptide. Cleavage by signal peptidase (SP) separates E1 from the complete form of core protein, anchored in the endoplasmic reticulum (ER) membrane by the signal peptide. Subsequent cleavage of the signal peptide by signal-peptide peptidase (SPP) releases the mature form of core protein, which preferentially relocates to lipid droplets. Both of these cleavages are required for the HCV infectious cycle, supporting the idea that HCV assembly begins at the surface of lipid droplets, yet SPP-catalyzed cleavage is dispensable for initiation of budding in the ER. Here we have addressed at what step(s) of the HCV infectious cycle SP-catalyzed cleavage at the core-E1 junction is required. Taking advantage of the sole system that has allowed visualization of HCV budding events in the ER lumen of mammalian cells, we showed that, unexpectedly, mutations abolishing this cleavage did not prevent but instead tended to promote the initiation of viral budding. Moreover, even though no viral particles were released from Huh-7 cells transfected with a full-length HCV genome bearing these mutations, intracellular viral particles containing core protein protected by a membrane envelope were formed. These were visualized by electron microscopy as capsid-containing particles with a diameter of about 70 nm and 40 nm before and after delipidation, respectively, comparable to intracellular wild-type particle precursors except that they were non-infectious. Thus, our results show that SP-catalyzed cleavage is dispensable for HCV budding per se, but is required for the viral particles to acquire their infectivity and secretion. These data support the idea that HCV assembly occurs in concert with budding at the ER membrane. Furthermore, capsid-containing particles did not accumulate in the absence of SP-catalyzed cleavage, suggesting the quality of newly formed viral particles is controlled before secretion. PMID:28437468

Enhanced electrochemical performance of sulfur/polyacrylonitrile composite by carbon coating for lithium/sulfur batteries

NASA Astrophysics Data System (ADS)

Peng, Huifen; Wang, Xiaoran; Zhao, Yan; Tan, Taizhe; Mentbayeva, Almagul; Bakenov, Zhumabay; Zhang, Yongguang

2017-10-01

A carbon-coated sulfur/polyacrylonitrile (C@S/PAN) core-shell structured composite is successfully prepared via a novel solution processing method. The sulfur/polyacrylonitrile (S/PAN) core particle has a diameter of 100 nm, whereas the carbon shell is about 2 nm thick. The as-prepared C@S/PAN composite shows outstanding electrochemical performance in lithium/sulfur (Li/S) batteries delivering a high initial discharge capacity of 1416 mAh g-1. Furthermore, it exhibits 89% retention of the initial reversible capacity over 200 cycles at a constant current rate of 0.1 C. The improved performance contributed by the unique composition and the core-shell structure, wherein carbon matrix can also withstand the volume change of sulfur during the process of charging and discharging as well as provide channels for electron transport. In addition, polyacrylonitrile (PAN) matrix suppresses the shuttle effect by the covalent bonding between sulfur (S) and carbon (C) in the PAN matrix. [Figure not available: see fulltext.

Weather Research and Forecasting Model Wind Sensitivity Study at Edwards Air Force Base, CA

NASA Technical Reports Server (NTRS)

Watson, Leela R.; Bauman, William H., III; Hoeth, Brian

2009-01-01

This abstract describes work that will be done by the Applied Meteorology Unit (AMU) in assessing the success of different model configurations in predicting "wind cycling" cases at Edwards Air Force Base, CA (EAFB), in which the wind speeds and directions oscillate among towers near the EAFB runway. The Weather Research and Forecasting (WRF) model allows users to choose among two dynamical cores - the Advanced Research WRF (ARW) and the Non-hydrostatic Mesoscale Model (NMM). There are also data assimilation analysis packages available for the initialization of the WRF model - the Local Analysis and Prediction System (LAPS) and the Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS). Having a series of initialization options and WRF cores, as well as many options within each core, creates challenges for local forecasters, such as determining which configuration options are best to address specific forecast concerns. The goal of this project is to assess the different configurations available and determine which configuration will best predict surface wind speed and direction at EAFB.

The CROWN initiative: journal editors invite researchers to develop core outcomes in women’s health

PubMed Central

2014-01-01

Clinical trials, systematic reviews and guidelines compare beneficial and non-beneficial outcomes following interventions. Often, however, various studies on a particular topic do not address the same outcomes, making it difficult to draw clinically useful conclusions when a group of studies is looked at as a whole. This problem was recently thrown into sharp focus by a systematic review of interventions for preterm birth prevention, which found that among 103 randomised trials, no fewer than 72 different outcomes were reported. There is a growing recognition among clinical researchers that this variability undermines consistent synthesis of the evidence, and that what is needed is an agreed standardised collection of outcomes - a "core outcomes set" - for all trials in a specific clinical area. Recognising that the current inconsistency is a serious hindrance to progress in our specialty, the editors of over 50 journals related to women's health have come together to support The CROWN (CoRe Outcomes in WomeN's health) Initiative. PMID:25048583

The CROWN initiative: journal editors invite researchers to develop core outcomes in women’s health

PubMed Central

2014-01-01

Clinical trials, systematic reviews and guidelines compare beneficial and non-beneficial outcomes following interventions. Often, however, various studies on a particular topic do not address the same outcomes, making it difficult to draw clinically useful conclusions when a group of studies is looked at as a whole. This problem was recently thrown into sharp focus by a systematic review of interventions for preterm birth prevention, which found that among 103 randomised trials, no fewer than 72 different outcomes were reported. There is a growing recognition among clinical researchers that this variability undermines consistent synthesis of the evidence, and that what is needed is an agreed standardised collection of outcomes - a “core outcomes set” - for all trials in a specific clinical area. Recognising that the current inconsistency is a serious hindrance to progress in our specialty, the editors of over 50 journals related to women’s health have come together to support The CROWN (CoRe Outcomes in WomeN’s health) Initiative. PMID:24957208

The CROWN Initiative: journal editors invite researchers to develop core outcomes in women’s health

PubMed Central

2014-01-01

Clinical trials, systematic reviews and guidelines compare beneficial and non-beneficial outcomes following interventions. Often, however, various studies on a particular topic do not address the same outcomes, making it difficult to draw clinically useful conclusions when a group of studies is looked at as a whole. This problem was recently thrown into sharp focus by a systematic review of interventions for preterm birth prevention, which found that among 103 randomised trials, no fewer than 72 different outcomes were reported. There is a growing recognition among clinical researchers that this variability undermines consistent synthesis of the evidence, and that what is needed is an agreed standardised collection of outcomes - a "core outcomes set" - for all trials in a specific clinical area. Recognising that the current inconsistency is a serious hindrance to progress in our specialty, the editors of over 50 journals related to women's health have come together to support The CROWN (CoRe Outcomes in WomeN's health) Initiative. PMID:25050130

The Impact of the Nuclear Equation of State in Core Collapse Supernovae

NASA Astrophysics Data System (ADS)

Baird, M. L.; Lentz, E. J.; Hix, W. R.; Mezzacappa, A.; Messer, O. E. B.; Liebendoerfer, M.; TeraScale Supernova Initiative Collaboration

2005-12-01

One of the key ingredients to the core collapse supernova mechanism is the physics of matter at or near nuclear density. Included in simulations as part of the Equation of State (EOS), nuclear repulsion experienced at high densities are responsible for the bounce shock, which initially causes the outer envelope of the supernova to expand, as well as determining the structure of the newly formed proto-neutron star. Recent years have seen renewed interest in this fundamental piece of supernova physics, resulting in several promising candidate EOS parameterizations. We will present the impact of these variations in the nuclear EOS using spherically symmetric, Newtonian and General Relativistic neutrino transport simulations of stellar core collapse and bounce. This work is supported in part by SciDAC grants to the TeraScale Supernovae Initiative from the DOE Office of Science High Energy, Nuclear, and Advanced Scientific Computing Research Programs. Oak Ridge National Laboratory is managed by UT-Battelle, LLC, for U.S. Department of Energy under contract DEAC05-00OR22725

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vinnikov, B.; NRC Kurchatov Inst.

According to Scientific and Technical Cooperation between the USA and Russia in the field of nuclear engineering the Idaho National Laboratory has transferred to the possession of the National Research Center ' Kurchatov Inst. ' the SAPHIRE software without any fee. With the help of the software Kurchatov Inst. developed a Pilot Living PSA- Model of Leningrad NPP Unit 1. Computations of core damage frequencies were carried out for additional Initiating Events. In the submitted paper such additional Initiating Events are fires in various compartments of the NPP. During the computations of each fire, structure of the PSA - Modelmore » was not changed, but Fault Trees for the appropriate systems, which are removed from service during the fire, were changed. It follows from the computations, that for ten fires Core Damaged Frequencies (CDF) are not changed. Other six fires will cause additional core damage. On the basis of the calculated results it is possible to determine a degree of importance of these fires and to establish sequence of performance of fire-prevention measures in various places of the NPP. (authors)« less

On the recovery of electric currents in the liquid core of the Earth

NASA Astrophysics Data System (ADS)

Kuslits, Lukács; Prácser, Ernő; Lemperger, István

2017-04-01

Inverse geodynamo modelling has become a standard method to get a more accurate image of the processes within the outer core. In this poster excerpts from the preliminary results of an other approach are presented. This comes around the possibility of recovering the currents within the liquid core directly, using Main Magnetic Field data. The approximation of different systems of the flow of charge is possible with various geometries. Based on previous geodynamo simulations, current coils can furnish a good initial geometry for such an estimation. The presentation introduces our preliminary test results and the study of reliability of the applied inversion algorithm for different numbers of coils, distributed in a grid simbolysing the domain between the inner-core and core-mantle boundaries. We shall also present inverted current structures using Main Field model data.

New Progress on Radiocarbon Geochronology in Southern Lake Tanganyika (East Africa)

NASA Astrophysics Data System (ADS)

McGlue, M. M.; Soreghan, M. J.

2017-12-01

Our limnogeological research in Lake Tanganyika focuses on elucidating the patterns of sediment accumulation on deepwater horsts, outer platforms, and littoral environments in the lake's southern basin ( 6-8°S latitude). Here, we present new radiocarbon (14C) dates from high-quality surface sediment cores, in order to make comparisons with previously published age models, to address the presence and spatiotemporal variability of a reservoir effect, and to constrain sedimentation rates and facies at sites that may be important targets for future scientific drilling. Plant macrofossils are rare in deepwater sediment cores, so charcoal and bulk organic matter have been the primary materials used for dating. On the Kavala Island Ridge (KIR) horst, initial core descriptions revealed variations in laminae presence, thickness, and chemistry. Sediment cores from the KIR at 172m water depth consist of thickly laminated diatom oozes. Charcoal from the bases of these cores returned median ages of 2.1-2.2 cal ka, suggesting linear accumulation rates on the order of 0.51 mm/yr. By contrast, a core from 420 m water depth on the KIR exhibited very thin laminations and diatom layers were much less prominent. Charcoal at the base of this core produced a median age of 8.1 cal ka, suggesting a linear accumulation rate of 0.11 mm/yr. These initial results suggest that sedimentation rates may vary considerably over sublacustrine horst blocks. We will test this initial discovery with additional sedimentation rate information from the Kalya and Nitiri horsts. In addition, we report new 14C dates made on both dead and live-collected shells of the endemic gastropod Neothauma tanganyicense. These shells form vast accumulations along shallow-water platforms of the lake and form an important substrate for a number of other endemic species. The discovery of living snails in southern Lake Tanganyika may allow for the development of a species-specific reservoir correction. A limited N. tanganyicense shell 14C dataset from the lake's northern basin exhibits time averaged over the past 1600 cal yrs; results from this project will begin to address spatial variability in time averaging, and therefore improve our understanding of shell bed formation and the extent to which anthropogenic sedimentation is impacting shell bed persistence.

Reference Architecture for MNE 5 Technical System

DTIC Science & Technology

2007-05-30

of being available in most experiments. Core Services A core set of applications whi directories, web portal and collaboration applications etc. A...classifications Messages (xml, JMS, content level…) Meta data filtering, who can initiate services Web browsing Collaboration & messaging Border...Exchange Ref Architecture for MNE5 Tech System.doc 9 of 21 audit logging Person and machine Data lev objects, web services, messages rification el

Enacting Common Core Instruction: How Intermediate Unit 13 Leveraged Its Position as an Educational Service Agency to Implement and Scale the LDC Initiative

ERIC Educational Resources Information Center

Research For Action, 2014

2014-01-01

Funded by The Bill & Melinda Gates Foundation, the Literacy Design Collaborative (LDC) and Math Design Collaborative (MDC) offer a set of instructional and formative assessment tools in literacy and math, which were developed to help educators better prepare all students to meet the Common Core State Standards (CCSS) and succeed beyond high…

Willing but Not Yet Ready: A Glimpse of California Teachers' Preparedness for the Common Core State Standards. CenterView

ERIC Educational Resources Information Center

Center for the Future of Teaching and Learning at WestEd, 2012

2012-01-01

California is on the precipice of implementing the Common Core State Standards (CCSS), which were developed through an initiative of the National Governors Association and the Council of Chief State School Officers to reflect the knowledge and skills needed for success in college and careers. In California, one of 45 adopting states, the standards…

Open up the Ceiling on the Common Core State Standards: Preparing Students for 21st-Century Literacy--Now

ERIC Educational Resources Information Center

Drew, Sally Valentino

2013-01-01

The Common Core State Standards Initiative is the latest effort to reform education through standards. This article examines how the Standards promise to prepare students for the changing world of the 21st century, yet do not consider the changing nature of literacy--especially the centrality of the Internet as a 21st century text, and online…

It's Not Education by Zip Code Anymore--But What is It? Conceptions of Equity under the Common Core

ERIC Educational Resources Information Center

Kornhaber, Mindy L.; Griffith, Kelly; Tyler, Alison

2014-01-01

The Common Core State Standards Initiative is a standards-based reform in which 45 U.S. states and the District of Columbia have agreed to participate. The reform seeks to anchor primary and secondary education across these states in one set of demanding, internationally benchmarked standards. Thereby, all students will be prepared for further…

Knockout beyond the dripline

NASA Astrophysics Data System (ADS)

Bonaccorso, A.; Charity, R. J.; Kumar, R.; Salvioni, G.

2015-02-01

In this contribution, we will describe neutron and proton removal from 9C and 7Be which are two particularly interesting nuclei entering the nucleo-synthesis pp-chain [1, 2]. Neutron and proton removal reactions have been used in the past twenty years to probe the single-particle structure of exotic nuclei. The core parallel-momentum distribution can give information on the angular momentum and spin of the nucleon initial state while the total removal cross section is sensitive to the asymptotic part of the initial wave function and also to the reaction mechanism. Because knockout is a peripheral reaction from which the Asymptotic Normalization Constant (ANC) of the single-particle wave function can be extracted, it has been used as an indirect method to obtain the rate of reactions like 8B ( p ,γ)9C or 7Be ( p ,γ)8B . Nucleon removal has recently been applied by the HiRA collaboration [3] to situations in which the remaining "core" is beyond the drip line, such as 8C and 6Be , unbound by one or more protons, and whose excitation-energy spectrum can be obtained by the invariant-mass method. By gating on the ground-state peak, "core" parallel-momentum distributions and total knockout cross sections have been obtained similar to previous studies with well-bound "cores". In addition for each projectile, knock out to final bound states has also been obtained in several cases. We will report on the theoretical description and comparison to this experimental data for a few cases for which advances in the accuracy of the transfer-to-the continuum model [4, 5] have been made [6]. These include the use, when available, of "ab-initio" overlaps for the initial state [7] and in particular their ANC values [8]. Also, the construction of a nucleus-target folding potential for the treatment of the core-target S-matrix [9] using for the cores "ab-initio" densities [10] and state-of-the-art n-9Be optical potentials [11]. Preliminary results and open problems will be discussed.

Osmium Isotope Compositions of Komatiite Sources Through Time

NASA Astrophysics Data System (ADS)

Walker, R. J.

2001-12-01

Extending Os isotopic measurements to ancient plume sources may help to constrain how and when the well-documented isotopic heterogeneities in modern systems were created. Komatiites and picrites associated with plume-related volcanism are valuable tracers of the Os isotopic composition of plumes because of their typically high Os concentrations and relatively low Re/Os. Re-Os data are now available for a variety of Phanerozoic, Proterozoic and Archean komatiites and picrites. As with modern plumes, the sources of Archean and Proterozoic komatiites exhibit a large range of initial 187Os/188Os ratios. Most komatiites are dominated by sources with chondritic Os isotopic compositions (e.g. Song La; Norseman-Wiluna; Pyke Hill; Alexo), though some (e.g. Gorgona) derive from heterogeneous sources. Of note, however, two ca. 2.7 Ga systems, Kostomuksha (Russia) and Belingwe (Zimbabwe), have initial ratios enriched by 2-3% relative to the contemporary convecting upper mantle. These results suggest that if the 187Os enrichment was due to the incorporation of minor amounts of recycled crust into the mantle source of the rocks, the crust formed very early in Earth history. Thus, the Os results could reflect derivation of melt from hybrid mantle whose composition was modified by the addition of mafic crustal material that would most likely have formed between 4.2 and 4.5 Ga. Alternately, the mantle sources of these komatiites may have derived a portion of their Os from the putative 187Os - and 186Os -enriched outer core. For this hypothesis to be applicable to Archean rocks, an inner core of sufficient mass would have to have crystallized sufficiently early in Earth history to generate an outer core with 187Os enriched by at least 3% relative to the chondritic average. Using the Pt-Re-Os partition coefficients espoused by our earlier work, and assuming linear growth of the inner core started at 4.5 Ga and continued to present, would yield an outer core at 2.7 Ga with a gamma Os value of only +1.2 and a 186Os/188Os enrichment relative to the contemporary upper mantle of only +13 ppm. Greater isotopic enrichments could have been achieved by 2.7 Ga if either the inner core comprised >2.8% of the mass of the core by 2.7 Ga, or if Re and Os solid metal-liquid metal D's for core crystallization were greater that those applied in the initial calculation.

Initiation of Coronal Mass Ejections by Tether-Cutting Reconnection

NASA Technical Reports Server (NTRS)

Moore, Ronald L.; Sterling, Alphonse C.; Falconer, David A.; Six, N. Frank (Technical Monitor)

2002-01-01

We present and interpret examples of the eruptive motion and flare brightening observed in the onset of magnetic explosions that produce coronal mass ejections. The observations are photospheric magnetograms and sequences of coronal and/or chromospheric images. In our examples, the explosion is apparently driven by the ejective eruption of a sigmoidal sheared-field flux rope from the core of an initially closed bipole. This eruption is initiated (triggered and unleashed) by reconnection located either (1) internally, low in the sheared core field, or (2) externally, at a magnetic null above the closed bipole. The internal reconnection is commonly called 'tether-cutting" reconnection, and the external reconnection is commonly called "break-out' reconnection. We point out that break-out reconnection amounts to external tether cutting. In one example, the eruptive motion of the sheared core field starts several minutes prior to any detectable brightening in the coronal images. We suggest that in this case the eruption is triggered by internal tether-cutting reconnection that at first is too slow and/or too localized to produce detectable heating in the coronal images. This work is supported by NASA's Office of Space Science through its Solar & Heliospheric Physics Supporting Research & Technology program and its Sun-Earth Connection Guest Investigator program.

[Response to and further development of the Choosing wisely initiative].

PubMed

Fölsch, U R; Hallek, M; Raupach, T; Hasenfuß, G

2017-06-01

The Choosing wisely initiative of the German Society of Internal Medicine ("Deutschen Gesellschaft für Innere Medizin," DGIM) and its 12 core focus area specialist societies were brought into being in 2014. The German initiative differs from the American campaign in that it not only considers overuse of diagnostic and therapeutic healthcare services, but also addresses procedures which are frequently not performed although they would bring benefits for patients. Furthermore, the recommendations were approved by an interdisciplinary consensus commission under consideration of all key internal medicine aspects. Since 2014, the initiative has received widespread attention. The 115 recommendations approved by the consensus commission have meanwhile been published in 20 articles. An array of measures were subsequently adopted to further promote the Choosing wisely recommendations ("Klug-entscheiden-Empfehlungen," KEE). These include the systematic incorporation of KEE symposia into DGIM annual congresses and the congresses of the core focus area specialist societies, as well as consideration of the KEE during establishment of future guidelines. Particular attention was paid to the importance of initiating and promoting a research project aimed at familiarizing medical students with the principles and content of the Choosing wisely initiative. The decision for or against specific diagnostic and therapeutic procedures represents an essential medical competence, which should therefore be trained prior to qualification.

Tunable plasmon resonance and enhanced second harmonic generation and upconverted fluorescence of hemispheric-like silver core/shell islands

NASA Astrophysics Data System (ADS)

Ding, Si-Jing; Nan, Fan; Yang, Da-Jie; Zhong, Yu-Ting; Hao, Zhong-Hua; Wang, Qu-Quan

2015-09-01

We investigate tunable plasmon resonance and enhanced second harmonic generation (SHG) and up-converted fluorescence (UCF) of the hemispheric-like silver core/shell islands. The Ag, Ag/Ag2O, and Ag/Ag2O/Ag island films are prepared by using a sputtering technique. The SHG and UCF of the Ag/Ag2O/Ag core/shell islands near the percolating regime is enhanced 2.34 and 3.94 times compared to the sum of two individual counterparts of Ag/Ag2O core/shell and Ag shell islands. The ratio of SHG intensity induced by p- and s-polarization is 0.86 for the initial Ag islands and increase to 1.61 for the Ag/Ag2O/Ag core/shell samples. The tunable intensity ratio of SHG to UCF of the Ag islands treated by thermal and laser annealing processes is also observed. The physical mechanism of the enhanced SHG and UCF in the Ag/Ag2O/Ag core/shell islands is discussed. Our observations provide a new approach to fabricate plasmon-enhanced optical nonlinear nanodevices with tunable SHG and UCF.We investigate tunable plasmon resonance and enhanced second harmonic generation (SHG) and up-converted fluorescence (UCF) of the hemispheric-like silver core/shell islands. The Ag, Ag/Ag2O, and Ag/Ag2O/Ag island films are prepared by using a sputtering technique. The SHG and UCF of the Ag/Ag2O/Ag core/shell islands near the percolating regime is enhanced 2.34 and 3.94 times compared to the sum of two individual counterparts of Ag/Ag2O core/shell and Ag shell islands. The ratio of SHG intensity induced by p- and s-polarization is 0.86 for the initial Ag islands and increase to 1.61 for the Ag/Ag2O/Ag core/shell samples. The tunable intensity ratio of SHG to UCF of the Ag islands treated by thermal and laser annealing processes is also observed. The physical mechanism of the enhanced SHG and UCF in the Ag/Ag2O/Ag core/shell islands is discussed. Our observations provide a new approach to fabricate plasmon-enhanced optical nonlinear nanodevices with tunable SHG and UCF. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr03627e

Plasma current start-up by the outer ohmic heating coils in the Saskatchewan TORus Modified (STOR-M) iron core tokamak

DOE PAGES

Mitarai, O.; Xiao, C.; McColl, D.; ...

2015-03-24

A plasma current up to 15 kA has been driven with outer ohmic heating (OH) coils in the STOR-M iron core tokamak. Even when the inner OH coil is disconnected, the outer OH coils alone can induce the plasma current as primary windings and initial breakdown are even easier in this coil layout. Our results suggest a possibility to use an iron core in a spherical tokamak to start up the plasma current without a central solenoid. Finally, the effect of the iron core saturation on the extension of the discharge pulse length has been estimated for further experiments inmore » the STOR-M tokamak.« less

Development of a Core Competency Model for the Master of Public Health Degree

PubMed Central

Calhoun, Judith G.; Ramiah, Kalpana; Weist, Elizabeth McGean; Shortell, Stephen M.

2008-01-01

Core competencies have been used to redefine curricula across the major health professions in recent decades. In 2006, the Association of Schools of Public Health identified core competencies for the master of public health degree in graduate schools and programs of public health. We provide an overview of the model development process and a listing of 12 core domains and 119 competencies that can serve as a resource for faculty and students for enhancing the quality and accountability of graduate public health education and training. The primary vision for the initiative is the graduation of professionals who are more fully prepared for the many challenges and opportunities in public health in the forthcoming decade. PMID:18633093

Plasma current start-up by the outer ohmic heating coils in the Saskatchewan TORus Modified (STOR-M) iron core tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitarai, O.; Xiao, C.; McColl, D.

A plasma current up to 15 kA has been driven with outer ohmic heating (OH) coils in the STOR-M iron core tokamak. Even when the inner OH coil is disconnected, the outer OH coils alone can induce the plasma current as primary windings and initial breakdown are even easier in this coil layout. Our results suggest a possibility to use an iron core in a spherical tokamak to start up the plasma current without a central solenoid. Finally, the effect of the iron core saturation on the extension of the discharge pulse length has been estimated for further experiments inmore » the STOR-M tokamak.« less

Building the Core Architecture of a Multiagent System Product Line: With an example from a future NASA Mission

NASA Technical Reports Server (NTRS)

Pena, Joaquin; Hinchey, Michael G.; Ruiz-Cortes, Antonio

2006-01-01

The field of Software Product Lines (SPL) emphasizes building a core architecture for a family of software products from which concrete products can be derived rapidly. This helps to reduce time-to-market, costs, etc., and can result in improved software quality and safety. Current AOSE methodologies are concerned with developing a single Multiagent System. We propose an initial approach to developing the core architecture of a Multiagent Systems Product Line (MAS-PL), exemplifying our approach with reference to a concept NASA mission based on multiagent technology.

Core Physics and Kinetics Calculations for the Fissioning Plasma Core Reactor

NASA Technical Reports Server (NTRS)

Butler, C.; Albright, D.

2007-01-01

Highly efficient, compact nuclear reactors would provide high specific impulse spacecraft propulsion. This analysis and numerical simulation effort has focused on the technical feasibility issues related to the nuclear design characteristics of a novel reactor design. The Fissioning Plasma Core Reactor (FPCR) is a shockwave-driven gaseous-core nuclear reactor, which uses Magneto Hydrodynamic effects to generate electric power to be used for propulsion. The nuclear design of the system depends on two major calculations: core physics calculations and kinetics calculations. Presently, core physics calculations have concentrated on the use of the MCNP4C code. However, initial results from other codes such as COMBINE/VENTURE and SCALE4a. are also shown. Several significant modifications were made to the ISR-developed QCALC1 kinetics analysis code. These modifications include testing the state of the core materials, an improvement to the calculation of the material properties of the core, the addition of an adiabatic core temperature model and improvement of the first order reactivity correction model. The accuracy of these modifications has been verified, and the accuracy of the point-core kinetics model used by the QCALC1 code has also been validated. Previously calculated kinetics results for the FPCR were described in the ISR report, "QCALC1: A code for FPCR Kinetics Model Feasibility Analysis" dated June 1, 2002.

Preliminary Physical Stratigraphy and Geophysical Data of the USGS Hope Plantation Core (BE-110), Bertie County, North Carolina

USGS Publications Warehouse

Weems, Robert E.; Seefelt, Ellen L.; Wrege, Beth M.; Self-Trail, Jean M.; Prowell, David C.; Durand, Colleen; Cobbs, Eugene F.; McKinney, Kevin C.

2007-01-01

Introduction In March and April, 2004, the U.S. Geological Survey (USGS), in cooperation with the North Carolina Geological Survey (NCGS) and the Raleigh Water Resources Discipline (WRD), drilled a stratigraphic test hole and well in Bertie County, North Carolina (fig. 1). The Hope Plantation test hole (BE-110-2004) was cored on the property of Hope Plantation near Windsor, North Carolina. The drill site is located on the Republican 7.5 minute quadradrangle at lat 36?01'58'N., long 78?01'09'W. (decimal degrees 36.0329 and 77.0192) (fig. 2). The altitude of the site is 48 ft above mean sea level as determined by Paulin Precise altimeter. This test hole was continuously cored by Eugene F. Cobbs, III and Kevin C. McKinney (USGS) to a total depth of 1094.5 ft. Later, a ground water observation well was installed with a screened interval between 315-329 feet below land surface (fig. 3). Upper Triassic, Lower Cretaceous, Upper Cretaceous, Tertiary, and Quaternary sediments were recovered from the site. The core is stored at the NCGS Coastal Plain core storage facility in Raleigh, North Carolina. In this report, we provide the initial lithostratigraphic summary recorded at the drill site along with site core photographs, data from the geophysical logger, calcareous nannofossil biostratigraphic correlations (Table 1) and initial hydrogeologic interpretations. The lithostratigraphy from this core can be compared to previous investigations of the Elizabethtown corehole, near Elizabethtown, North Carolina in Bladen County (Self-Trail, Wrege, and others, 2004), the Kure Beach corehole, near Wilmington, North Carolina in New Hanover County (Self-Trail, Prowell, and Christopher, 2004), the Esso #1, Esso #2, Mobil #1 and Mobil #2 cores in the Albermarle and Pamlico Sounds (Zarra, 1989), and the Cape Fear River outcrops in Bladen County (Farrell, 1998; Farrell and others, 2001). This core is the third in a series of planned benchmark coreholes that will be used to elucidate the physical stratigraphy, facies, thickness, and hydrogeology of the Tertiary and Cretaceous Coastal Plain sediments of North Carolina.

Why Do We Need Future Ready Librarians? That Kid.

ERIC Educational Resources Information Center

Ray, Mark

2018-01-01

In this article, the author examines the need of the Future Ready Librarians (FRL) initiative. The FRL Framework helps define how librarians might lead, teach, and support schools based on the core research-based components defined by Future Ready. The framework and initiative are intended to be ways to change the conversation about school…

Technology Transfer and Innovation Initiatives in Strategic Management: Generating an Alternative Perspective

ERIC Educational Resources Information Center

Major, E.

2003-01-01

This paper taps the strategic management discipline to inform our understanding of technology transfer and innovation (TTI) initiatives. With special focus on the UK Foresight programme it considers the impacts that the resource-based and core competence approaches to strategy can have on understanding the nature and effectiveness of TTI…

Schools Uniting Neighborhoods: The SUN Initiative in Portland, Oregon

ERIC Educational Resources Information Center

Iverson, Dianne

2005-01-01

The Schools Uniting Neighborhoods (SUN) Community Schools Initiative is a community-driven model that allows each school community to design the programs that fit neighborhood needs, while working toward core goals that stretch across all SUN Community Schools. In this article, the author describes the history of SUN Community Schools and its core…

Teacher Placement, Mobility, and Occupational Choices after Teaching

ERIC Educational Resources Information Center

Feng, Li

2014-01-01

Teachers' initial placement has important implications for student achievement and the distribution of teachers among schools. This paper combines data from a US Baccalaureate and Beyond longitudinal study with school and school district information from the Common Core of Data to study the effects of initial school placement on teacher mobility.…

World Community: Middlesex CC Infuses Global Initiatives into Core Curriculum and beyond

ERIC Educational Resources Information Center

Cowan, Carole A.

2006-01-01

Twenty years ago, Middlesex Community College (MCC) in Massachusetts decided to add a global focus to its programs. Since then, the college has garnered worldwide recognition for the range of international initiatives it has integrated into its curriculum across academic disciplines. Today, Middlesex offers unique opportunities for international…

Teaching Students Personal and Social Responsibility with Measurable Learning Outcomes

ERIC Educational Resources Information Center

Ardaiolo, Frank P.; Neilson, Steve; Daugherty, Timothy K.

2011-01-01

In 2005 the Association of American Colleges and Universities (AAC&U) launched a national initiative that championed the importance of a twenty-first century liberal education. What was unique about this initiative was the underlying assumption that educating for personal and social responsibility was "core" for an educated citizenry and should be…

Convection of Plasmaspheric Plasma into the Outer Magnetosphere and Boundary Layer Region: Initial Results

NASA Technical Reports Server (NTRS)

Ober, Daniel M.; Horwitz, J. L.

1998-01-01

We present initial results on the modeling of the circulation of plasmaspheric-origin plasma into the outer magnetosphere and low-latitude boundary layer (LLBL), using a dynamic global core plasma model (DGCPM). The DGCPM includes the influences of spatially and temporally varying convection and refilling processes to calculate the equatorial core plasma density distribution throughout the magnetosphere. We have developed an initial description of the electric and magnetic field structures in the outer magnetosphere region. The purpose of this paper is to examine both the losses of plasmaspheric-origin plasma into the magnetopause boundary layer and the convection of this plasma that remains trapped on closed magnetic field lines. For the LLBL electric and magnetic structures we have adopted here, the plasmaspheric plasma reaching the outer magnetosphere is diverted anti-sunward primarily along the dusk flank. These plasmas reach X= -15 R(sub E) in the LLBL approximately 3.2 hours after the initial enhancement of convection and continues to populate the LLBL for 12 hours as the convection electric field diminishes.

Hydrocode modeling of oblique impacts into terrestrial planets

NASA Astrophysics Data System (ADS)

Kendall, Jordan D.

The abundance of moderately siderophile elements ("iron-loving"; e.g., Co, Ni) in the Earth's mantle is 10 to 100 times larger than predicted by chemical equilibrium between silicate melt and iron at low pressure, but it does match expectation for equilibrium at high pressure and temperature. Recent studies of differentiated planetesimal impacts assume that planetesimal cores survive the impact intact as concentrated masses that passively settle from a zero initial velocity and undergo turbulent entrainment in a global magma ocean; under these conditions, cores greater than 10 km in diameter do not fully mix without a sufficiently deep magma ocean. I have performed hydrocode simulations that revise this assumption and yield a clearer picture of the impact process for differentiated planetesimals possessing iron cores with radius = 100 km that impact into magma oceans. The impact process strips away the silicate mantle of the planetesimal and then stretches the iron core, dispersing the liquid iron into a much larger volume of the underlying liquid silicate mantle. Lagrangian tracer particles track the initially intact iron core as the impact stretches and disperses the core. The final displacement distance of initially closest tracer pairs gives a metric of core stretching. The statistics of stretching imply mixing that separates the iron core into sheets, ligaments, and smaller fragments, on a scale of 10 km or less. The impact dispersed core fragments undergo further mixing through turbulent entrainment as the molten iron fragments sink through the magma ocean and settle deeper into the planet. My results thus support the idea that iron in the cores of even large differentiated planetesimals can chemically equilibrate deep in a terrestrial magma ocean. The largest known impact on the Moon formed the South Pole-Aitken (SP-A) basin and excavated material as deep as the mantle. Here I suggest that large impacts eject enough material to cover the farside of the Moon. During the impact process, ejecta leave the crater and travel well beyond the transient crater. Ejecta blankets depend on impactor size and angle. I use iSALE, an impact hydrocode, to determine the ejecta distribution, volume, and thickness. I calculate the trajectory of ejecta that leave the crater and return to the lunar surface. In these simulations, an ejecta blanket forms, with a thickness of kilometers, over the lunar farside. The ejecta blanket thicknesses are comparable to the difference between nearside and farside crustal thickness. Previous studies suggest other possible mechanisms for the lunar farside-nearside dichotomy. However, the impact that formed SP-A basin was large enough to eject material onto the farside. I also suggest a differentiated impactor's core would disperse downrange of the impact point underneath the basin. Doublet craters form within crater rays on terrestrial bodies. The near simultaneous impact of two projectiles results in overlapping craters. This process results in modified crater morphologies and ejecta morphologies. I modeled the impact of two identical projectiles and vary the angle, timing, and initial separation distance. In this work, I identified projectiles with a separation distance of four times their initial diameter will form distinct craters, but the ejecta from the uprange crater will overfill the downrange crater and result in a smaller crater depth. This result implies the direction of the impactor may be inferred from the crater depths. Also, I found impacts that form closer together result in elliptical or dumbbell craters depending upon the impact parameters. The ejecta curtains interact in each simulation and result in structures similar to the V-shaped ridges or "herringbone" patterns traversing clusters of secondary craters in observations. The ejecta that lands within the ridges comes from a depth that is 100 to 125 m for a 500 m impactor traveling at 1 km/s. This is less deep than the maximum excavation depth of 125 to 150 m, depending upon the impact angle. This work represents a first step towards a more comprehensive method for not only determining how doublet craters form and how aberrant craters form, such as Messier A on the Moon, but also determining how the regolith changes and the ejecta blanket forms for such impacts.

Core Formation and Evolution of Asteroid 4 Vesta

NASA Technical Reports Server (NTRS)

Kiefer, Walter S.; Mittlefehldt, David W.

2014-01-01

The howardites, eucrites, and diogenites (HEDs) are a suite of related meteorite types that formed by igneous and impact processes on the same parent body. Multiple lines of evidence, including infrared spectroscopy of the asteroid belt and the petrology and geochemistry of the HEDs, suggest that the asteroid 4 Vesta is the parent body for the HEDs. Observations by NASA's Dawn spacecraft mission strongly support the conclusion that the HEDs are from Vesta. The abundances of the moderately siderophile elements Ni, Co, Mo, W, and P in eucrites require that most or all of the metallic phase in Vesta segregated to form a core prior to eucrite solidification. These observations place important constraints on the mode and timescale of core formation on Vesta. Possible core formation mechanisms include porous flow, which potentially could occur prior to initiation of silicate melting, and metallic rain in a largely molten silicate magma ocean. Once the core forms, convection within the core could possible sustain a magnetic dynamo for a period of time. We consider each process in turn.

Planning and Execution of a Marine Methane Hydrate Pressure Coring Program for the Walker Ridge and Green Canyon Areas of the Gulf of Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Humphrey, Gary

The objective of this project (and report) is to produce a guide to developing scientific, operational, and logistical plans for a future methane hydrate-focused offshore pressure coring program. This report focuses primarily on a potential coring program in the Walker Ridge 313 and Green Canyon 955 blocks where previous investigations were undertaken as part of the 2009 Department of Energy JIP Leg II expedition, however, the approach to designing a pressure coring program that was utilized for this project may also serve as a useful model for planning pressure coring programs for hydrates in other areas. The initial portion ofmore » the report provides a brief overview of prior investigations related to gas hydrates in general and at the Walker Ridge 313 and Green Canyon 955 blocks in particular. The main content of the report provides guidance for various criteria that will come into play when designing a pressure coring program.« less

Investigating Anomalies in the Output Generated by the Weather Research and Forecasting (WRF) Model

NASA Astrophysics Data System (ADS)

Decicco, Nicholas; Trout, Joseph; Manson, J. Russell; Rios, Manny; King, David

2015-04-01

The Weather Research and Forecasting (WRF) model is an advanced mesoscale numerical weather prediction (NWP) model comprised of two numerical cores, the Numerical Mesoscale Modeling (NMM) core, and the Advanced Research WRF (ARW) core. An investigation was done to determine the source of erroneous output generated by the NMM core. In particular were the appearance of zero values at regularly spaced grid cells in output fields and the NMM core's evident (mis)use of static geographic information at a resolution lower than the nesting level for which the core is performing computation. A brief discussion of the high-level modular architecture of the model is presented as well as methods utilized to identify the cause of these problems. Presented here are the initial results from a research grant, ``A Pilot Project to Investigate Wake Vortex Patterns and Weather Patterns at the Atlantic City Airport by the Richard Stockton College of NJ and the FAA''.

High-pressure metallization of FeO and implications for the earth's core

NASA Technical Reports Server (NTRS)

Knittle, Elise; Jeanloz, Raymond

1986-01-01

The phase diagram of FeO has been experimentally determined to pressures of 155 GPa and temperatures of 4000 K using shock-wave and diamond-cell techniques. A metallic phase of FeO is observed at pressures greater than 70 GPa and temperatures exceeding 1000 K. The metallization of FeO at high pressures implies that oxygen can be present as the light alloying element of the earth's outer core, in accord with the geochemical predictions of Ringwood (1977 and 1979). The high pressures necessary for this metallization suggest that the core has acquired its composition well after the initial stages of the earth's accretion. Direct experimental observations at elevated pressures and temperatures indicate that core-forming alloy can react chemically with oxides such as those forming the mantle. The core and mantle may never have reached complete chemical equilibrium, however. If this is the case, the core-mantle boundary is likely to be a zone of active chemical reactions.

Vortex Core Size in the Rotor Near-Wake

NASA Technical Reports Server (NTRS)

Young, Larry A.

2003-01-01

Using a kinetic energy conservation approach, a number of simple analytic expressions are derived for estimating the core size of tip vortices in the near-wake of rotors in hover and axial-flow flight. The influence of thrust, induced power losses, advance ratio, and vortex structure on rotor vortex core size is assessed. Experimental data from the literature is compared to the analytical results derived in this paper. In general, three conclusions can be drawn from the work in this paper. First, the greater the rotor thrust, t h e larger the vortex core size in the rotor near-wake. Second, the more efficient a rotor is with respect to induced power losses, the smaller the resulting vortex core size. Third, and lastly, vortex core size initially decreases for low axial-flow advance ratios, but for large advance ratios core size asymptotically increases to a nominal upper limit. Insights gained from this work should enable improved modeling of rotary-wing aerodynamics, as well as provide a framework for improved experimental investigations of rotor a n d advanced propeller wakes.

Cool Core Disruption in Abell 1763

NASA Astrophysics Data System (ADS)

Douglass, Edmund; Blanton, Elizabeth L.; Clarke, Tracy E.; Randall, Scott W.; Edwards, Louise O. V.; Sabry, Ziad

2017-01-01

We present the analysis of a 20 ksec Chandra archival observation of the massive galaxy cluster Abell 1763. A model-subtracted image highlighting excess cluster emission reveals a large spiral structure winding outward from the core to a radius of ~950 kpc. We measure the gas of the inner spiral to have significantly lower entropy than non-spiral regions at the same radius. This is consistent with the structure resulting from merger-induced motion of the cluster’s cool core, a phenomenon seen in many systems. Atypical of spiral-hosting clusters, an intact cool core is not detected. Its absence suggests the system has experienced significant disruption since the initial dynamical encounter that set the sloshing core in motion. Along the major axis of the elongated ICM distribution we detect thermal features consistent with the merger event most likely responsible for cool core disruption. The merger-induced transition towards non-cool core status will be discussed. The interaction between the powerful (P1.4 ~ 1026 W Hz-1) cluster-center WAT radio source and its ICM environment will also be discussed.

Reactors as a Source of Antineutrinos: Effects of Fuel Loading and Burnup for Mixed-Oxide Fuels

NASA Astrophysics Data System (ADS)

Bernstein, Adam; Bowden, Nathaniel S.; Erickson, Anna S.

2018-01-01

In a conventional light-water reactor loaded with a range of uranium and plutonium-based fuel mixtures, the variation in antineutrino production over the cycle reflects both the initial core fissile inventory and its evolution. Under an assumption of constant thermal power, we calculate the rate at which antineutrinos are emitted from variously fueled cores, and the evolution of that rate as measured by a representative ton-scale antineutrino detector. We find that antineutrino flux decreases with burnup for low-enriched uranium cores, increases for full mixed-oxide (MOX) cores, and does not appreciably change for cores with a MOX fraction of approximately 75%. Accounting for uncertainties in the fission yields in the emitted antineutrino spectra and the detector response function, we show that the difference in corewide MOX fractions at least as small as 8% can be distinguished using a hypothesis test. The test compares the evolution of the antineutrino rate relative to an initial value over part or all of the cycle. The use of relative rates reduces the sensitivity of the test to an independent thermal power measurement, making the result more robust against possible countermeasures. This rate-only approach also offers the potential advantage of reducing the cost and complexity of the antineutrino detectors used to verify the diversion, compared to methods that depend on the use of the antineutrino spectrum. A possible application is the verification of the disposition of surplus plutonium in nuclear reactors.

Investigations of protostellar outflow launching and gas entrainment: Hydrodynamic simulations and molecular emission

DOE Office of Scientific and Technical Information (OSTI.GOV)

Offner, Stella S. R.; Arce, Héctor G., E-mail: stella.offner@yale.edu

2014-03-20

We investigate protostellar outflow evolution, gas entrainment, and star formation efficiency using radiation-hydrodynamic simulations of isolated, turbulent low-mass cores. We adopt an X-wind launching model, in which the outflow rate is coupled to the instantaneous protostellar accretion rate and evolution. We vary the outflow collimation angle from θ = 0.01-0.1 and find that even well-collimated outflows effectively sweep up and entrain significant core mass. The Stage 0 lifetime ranges from 0.14-0.19 Myr, which is similar to the observed Class 0 lifetime. The star formation efficiency of the cores spans 0.41-0.51. In all cases, the outflows drive strong turbulence in themore » surrounding material. Although the initial core turbulence is purely solenoidal by construction, the simulations converge to approximate equipartition between solenoidal and compressive motions due to a combination of outflow driving and collapse. When compared to simulation of a cluster of protostars, which is not gravitationally centrally condensed, we find that the outflows drive motions that are mainly solenoidal. The final turbulent velocity dispersion is about twice the initial value of the cores, indicating that an individual outflow is easily able to replenish turbulent motions on sub-parsec scales. We post-process the simulations to produce synthetic molecular line emission maps of {sup 12}CO, {sup 13}CO, and C{sup 18}O and evaluate how well these tracers reproduce the underlying mass and velocity structure.« less

Low hydrogen contents in the cores of terrestrial planets.

PubMed

Clesi, Vincent; Bouhifd, Mohamed Ali; Bolfan-Casanova, Nathalie; Manthilake, Geeth; Schiavi, Federica; Raepsaet, Caroline; Bureau, Hélène; Khodja, Hicham; Andrault, Denis

2018-03-01

Hydrogen has been thought to be an important light element in Earth's core due to possible siderophile behavior during core-mantle segregation. We reproduced planetary differentiation conditions using hydrogen contents of 450 to 1500 parts per million (ppm) in the silicate phase, pressures of 5 to 20 GPa, oxygen fugacity varying within IW-3.7 and IW-0.2 (0.2 to 3.7 log units lower than iron-wüstite buffer), and Fe alloys typical of planetary cores. We report hydrogen metal-silicate partition coefficients of ~2 × 10 -1 , up to two orders of magnitude lower than reported previously, and indicative of lithophile behavior. Our results imply H contents of ~60 ppm in the Earth and Martian cores. A simple water budget suggests that 90% of the water initially present in planetary building blocks was lost during planetary accretion. The retained water segregated preferentially into planetary mantles.

THE BRIGHTEST CLUSTER GALAXY IN A85: THE LARGEST CORE KNOWN SO FAR

DOE Office of Scientific and Technical Information (OSTI.GOV)

López-Cruz, O.; Añorve, C.; Ibarra-Medel, H. J.

2014-11-10

We have found that the brightest cluster galaxy (BCG) in A85, Holm 15A, displays the largest core known so far. Its cusp radius, r {sub γ} = 4.57 ± 0.06 kpc (4.''26 ± 0.''06), is more than 18 times larger than the mean for BCGs and ≳ 1 kpc larger than A2261-BCG, hitherto the largest-cored BCG. Holm 15A hosts the luminous amorphous radio source 0039-095B and has the optical signature of a LINER. Scaling laws indicate that this core could host a supermassive black hole (SMBH) of mass M {sub •} ∼ (10{sup 9}-10{sup 11}) M {sub ☉}. We suggestmore » that cores this large represent a relatively short phase in the evolution of BCGs, whereas the masses of their associated SBMH might be set by initial conditions.« less

A vortex-filament and core model for wings with edge vortex separation

NASA Technical Reports Server (NTRS)

Pao, J. L.; Lan, C. E.

1982-01-01

A vortex filament-vortex core method for predicting aerodynamic characteristics of slender wings with edge vortex separation was developed. Semi-empirical but simple methods were used to determine the initial positions of the free sheet and vortex core. Comparison with available data indicates that: (1) the present method is generally accurate in predicting the lift and induced drag coefficients but the predicted pitching moment is too positive; (2) the spanwise lifting pressure distributions estimated by the one vortex core solution of the present method are significantly better than the results of Mehrotra's method relative to the pressure peak values for the flat delta; (3) the two vortex core system applied to the double delta and strake wings produce overall aerodynamic characteristics which have good agreement with data except for the pitching moment; and (4) the computer time for the present method is about two thirds of that of Mehrotra's method.

Initial Neutronics Analyses for HEU to LEU Fuel Conversion of the Transient Reactor Test Facility (TREAT) at the Idaho National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kontogeorgakos, D.; Derstine, K.; Wright, A.

2013-06-01

The purpose of the TREAT reactor is to generate large transient neutron pulses in test samples without over-heating the core to simulate fuel assembly accident conditions. The power transients in the present HEU core are inherently self-limiting such that the core prevents itself from overheating even in the event of a reactivity insertion accident. The objective of this study was to support the assessment of the feasibility of the TREAT core conversion based on the present reactor performance metrics and the technical specifications of the HEU core. The LEU fuel assembly studied had the same overall design, materials (UO 2more » particles finely dispersed in graphite) and impurities content as the HEU fuel assembly. The Monte Carlo N–Particle code (MCNP) and the point kinetics code TREKIN were used in the analyses.« less

Effects of Burn Injuries on Thermoregulatory and Cardiovascular Responses in Soldiers: Implications for the Standards of Medical Fitness

DTIC Science & Technology

2017-10-01

greater elevation in core temperature during exercise. In exercise-based rehabilitation or physically demanding occupational settings, activities...Military Health System Research 2 Symposium. We have initiated data collection for Aim 1B (assessment of the impact of large/small statue on...resulting in exacerbated elevations in core temperature and greater risk of heat illness during physical activities. Since the capacity for

Transcatheter Aortic Valve Implantation: Experience with the CoreValve Device.

PubMed

Asgar, Anita W; Bonan, Raoul

2012-01-01

The field of transcatheter aortic valve implantation has been rapidly evolving. The Medtronic CoreValve first emerged on the landscape in 2004 with initial first human studies, and it is currently being studied in the Pivotal US trial. This article details the current experience with the self-expanding aortic valve with a focus on clinical results and ongoing challenges. Copyright © 2012 Elsevier Inc. All rights reserved.

Acoustics and dynamics of coaxial interacting vortex rings

NASA Technical Reports Server (NTRS)

Shariff, Karim; Leonard, Anthony; Zabusky, Norman J.; Ferziger, Joel H.

1988-01-01

Using a contour dynamics method for inviscid axisymmetric flow we examine the effects of core deformation on the dynamics and acoustic signatures of coaxial interacting vortex rings. Both 'passage' and 'collision' (head-on) interactions are studied for initially identical vortices. Good correspondence with experiments is obtained. A simple model which retains only the elliptic degree of freedom in the core shape is used to explain some of the calculated features.

Spheromak reactor with poloidal flux-amplifying transformer

DOEpatents

Furth, Harold P.; Janos, Alan C.; Uyama, Tadao; Yamada, Masaaki

1987-01-01

An inductive transformer in the form of a solenoidal coils aligned along the major axis of a flux core induces poloidal flux along the flux core's axis. The current in the solenoidal coil is then reversed resulting in a poloidal flux swing and the conversion of a portion of the poloidal flux to a toroidal flux in generating a spheromak plasma wherein equilibrium approaches a force-free, minimum Taylor state during plasma formation, independent of the initial conditions or details of the formation. The spheromak plasma is sustained with the Taylor state maintained by oscillating the currents in the poloidal and toroidal field coils within the plasma-forming flux core. The poloidal flux transformer may be used either as an amplifier stage in a moving plasma reactor scenario for initial production of a spheromak plasma or as a method for sustaining a stationary plasma and further heating it. The solenoidal coil embodiment of the poloidal flux transformer can alternately be used in combination with a center conductive cylinder aligned along the length and outside of the solenoidal coil. This poloidal flux-amplifying inductive transformer approach allows for a relaxation of demanding current carrying requirements on the spheromak reactor's flux core, reduces plasma contamination arising from high voltage electrode discharge, and improves the efficiency of poloidal flux injection.

Recognition of the Xenopus ribosomal core promoter by the transcription factor xUBF involves multiple HMG box domains and leads to an xUBF interdomain interaction.

PubMed

Leblanc, B; Read, C; Moss, T

1993-02-01

The interaction of the ribosomal transcription factor xUBF with the RNA polymerase I core promoter of Xenopus laevis has been studied both at the DNA and protein levels. It is shown that a single xUBF-DNA complex forms over the 40S initiation site (+1) and involves at least the DNA sequences between -20 and +60 bp. DNA sequences upstream of +10 and downstream of +18 are each sufficient to direct complex formation independently. HMG box 1 of xUBF independently recognizes the sequences -20 to -1 and +1 to +22 and the addition of the N-terminal dimerization domain to HMG box 1 stabilizes its interaction with these sequences approximately 10-fold. HMG boxes 2/3 interact with the DNA downstream of +22 and can independently position xUBF across the initiation site. The C-terminal segment of xUBF, HMG boxes 4, 5 or the acidic domain, directly or indirectly interact with HMG box 1, making the core promoter sequences between -11 and -15 hypersensitive to DNase. This interaction also requires the DNA sequences between +17 and +32, i.e. the HMG box 2/3 binding site. The data suggest extensive folding of the core promoter within the xUBF complex.

SiN-assisted polarization-insensitive multicore fiber to silicon photonics interface

NASA Astrophysics Data System (ADS)

Poulopoulos, Giannis N.; Kalavrouziotis, Dimitrios; Mitchell, Paul; Macdonald, John R.; Bakopoulos, Paraskevas; Avramopoulos, Hercules

2015-06-01

We demonstrate a polarization-insensitive coupler interfacing multicore-fiber (MCF) to silicon waveguides. It comprises a 3D glass fanout transforming the circular MCF core-arrangement to linear and performing initial tapering, followed by a Spot-Size-Converter on the silicon chip. Glass waveguides are formed of multiple overlapped modification elements and appropriate offsetting thereof yields tapers with symmetric cross-section. The Spot-Size-Converter is an inverselytapered silicon waveguide with a tapered polymer overcladding where light is initially coupled, whereas phase-matching gradually shifts it towards the silicon core. Co-design of the glass fanout and Spot-Size-Converter obtains theoretical loss below 1dB for the overall Si-to-MCF transition in both polarizations.

Conformational changes accompany activation of reovirus RNA-dependent RNA transcription

PubMed Central

Mendez, Israel I.; Weiner, Scott G.; She, Yi-Min; Yeager, Mark; Coombs, Kevin M.

2009-01-01

Many critical biologic processes involve dynamic interactions between proteins and nucleic acids. Such dynamic processes are often difficult to delineate by conventional static methods. For example, while a variety of nucleic acid polymerase structures have been determined at atomic resolution, the details of how some multi-protein transcriptase complexes actively produce mRNA, as well as conformational changes associated with activation of such complexes, remain poorly understood. The mammalian reovirus innermost capsid (core) manifests all enzymatic activities necessary to produce mRNA from each of the 10 encased double-stranded RNA genes. We used rapid freezing and electron cryo-microscopy to trap and visualize transcriptionally active reovirus core particles and compared them to inactive core images. Rod-like density centered within actively transcribing core spike channels was attributed to exiting nascent mRNA. Comparative radial density plots of active and inactive core particles identified several structural changes in both internal and external regions of the icosahedral core capsid. Inactive and transcriptionally active cores were partially digested with trypsin and identities of initial tryptic peptides determined by mass spectrometry. Differentially-digested peptides, which also suggest transcription-associated conformational changes, were placed within the known 3-dimensional structures of major core proteins. PMID:18321727

Contaminant trends in reservoir sediment cores as records of influent stream quality

USGS Publications Warehouse

Van Metre, P.C.; Mahler, B.J.

2004-01-01

When reconstructing water-quality histories from lake and reservoir cores, it is sometimes assumed that the chemical signatures in the cores reflect historical water quality in the influent streams. To investigate this assumption, concentrations of metals, PAHs, and organochlorine compounds in sediment cores were compared to those associated with an influent-stream suspended sediment for three reservoirs in Fort Worth, TX, and two reservoirs in Boston, MA, U.S.A., and interpreted in light of land-use and regulation histories. In evaluating relations between suspended sediments and cores, three levels of preservation were indicated: (1) influent concentrations and historical trends are preserved in cores (metals at all sites; some organic contaminants at some sites); (2) some loss occurs during transport and initial deposition but relative historical trends are preserved in cores (some organic contaminants at some sites); and (3) neither stream concentrations nor relative historical trends are preserved (dieldrin and p,p???-DDT). The degree of preservation of influent concentration histories varied between lakes, particularly for PAHs. The results support the use of sediment cores to infer streamwater-quality histories for many contaminants but indicate that reservoir-bottom sediment samples might underestimate concentrations of organic contaminants in some streams.

Initialization, Prediction and Diagnosis of the Rapid Intensification of Tropical Cyclones using the Australian Community Climate and Earth System Simulator, ACCESS

DTIC Science & Technology

2012-10-12

structure on the evolving storm behaviour. 13 7. Large scale influences on Rapid Intensification and Extratropical Transition: RI and ET...assimilation techniques to better initialize and validate TC structures (including the intense inner core and storm asymmetries) consistent with the large...Without vortex specification, initial conditions usually contain a weak and misplaced circulation. Based on estimates of central pressure and storm size

Floral Development of Berberidopsis corallina: a Crucial Link in the Evolution of Flowers in the Core Eudicots

PubMed Central

RONSE DE CRAENE, LOUIS P.

2004-01-01

• Background and Aims On the basis of molecular evidence Berberidopsidaceae have been linked with Aextoxicaceae in an order Berberidopsidales at the base of the core Eudicots. The floral development of Berberidopsis is central to the understanding of the evolution of floral configurations at the transition of the basal Eudicots to the core Eudicots. It lies at the transition of trimerous or dimerous, simplified apetalous forms into pentamerous, petaliferous flowers. • Methods The floral ontogeny of Berberidopsis was studied with a scanning electron microscope. • Key Results Flowers are grouped in terminal racemes with variable development. The relationship between the number of tepals, stamens and carpels is more or less fixed and floral initiation follows a strict 2/5 phyllotaxis. Two bracteoles, 12 tepals, eight stamens and three carpels are initiated in a regular sequence. The number of stamens can be increased by a doubling of stamen positions. • Conclusions The floral ontogeny of Berberidopsis provides support for the shift in floral bauplan from the basal Eudicots to the core Eudicots as a transition of a spiral flower with a 2/5 phyllotaxis to pentamerous flowers with two perianth whorls, two stamen whorls and a single carpel whorl. The differentiation of sepals and petals from bracteotepals is discussed and a comparison is made with other Eudicots with a similar configuration and development. Depending on the resolution of the relationships among the basalmost core Eudicots it is suggested that Berberidopsis either represents a critical stage in the evolution of pentamerous flowers of major clades of Eudicots, or has a floral prototype that may be at the base of evolution of flowers of other core Eudicots. The distribution of a floral Bauplan in other clades of Eudicots similar to Berberidopsidales is discussed. PMID:15451722

Fast and Luminous Transients from the Explosions of Long-lived Massive White Dwarf Merger Remnants

NASA Astrophysics Data System (ADS)

Brooks, Jared; Schwab, Josiah; Bildsten, Lars; Quataert, Eliot; Paxton, Bill; Blinnikov, Sergei; Sorokina, Elena

2017-12-01

We study the evolution and final outcome of long-lived (≈ {10}5 years) remnants from the merger of an He white dwarf (WD) with a more massive C/O or O/Ne WD. Using Modules for Experiments in Stellar Astrophysics ({\\mathtt{MESA}}), we show that these remnants have a red giant configuration supported by steady helium burning, adding mass to the WD core until it reaches {M}{core}≈ 1.12{--}1.20 {M}⊙ . At that point, the base of the surface convection zone extends into the burning layer, mixing the helium-burning products (primarily carbon and magnesium) throughout the convective envelope. Further evolution depletes the convective envelope of helium and dramatically slows the mass increase of the underlying WD core. The WD core mass growth re-initiates after helium depletion, as then an uncoupled carbon-burning shell is ignited and proceeds to burn the fuel from the remaining metal-rich extended envelope. For large enough initial total merger masses, O/Ne WD cores would experience electron-capture triggered collapse to neutron stars (NSs) after growing to near Chandrasekhar mass ({M}{Ch}). Massive C/O WD cores could suffer the same fate after a carbon-burning flame converts them to ONe. The NS formation would release ≈ {10}50 erg into the remaining extended low mass envelope. Using the STELLA radiative transfer code, we predict the resulting optical light curves from these exploded envelopes. Reaching absolute magnitudes of {M}V≈ -17, these transients are bright for about one week and have many features of the class of luminous, rapidly evolving transients studied by Drout and collaborators.

Prospect of Using Numerical Dynamo Model for Prediction of Geomagnetic Secular Variation

NASA Technical Reports Server (NTRS)

Kuang, Weijia; Tangborn, Andrew

2003-01-01

Modeling of the Earth's core has reached a level of maturity to where the incorporation of observations into the simulations through data assimilation has become feasible. Data assimilation is a method by which observations of a system are combined with a model output (or forecast) to obtain a best guess of the state of the system, called the analysis. The analysis is then used as an initial condition for the next forecast. By doing assimilation, not only we shall be able to predict partially secular variation of the core field, we could also use observations to further our understanding of dynamical states in the Earth's core. One of the first steps in the development of an assimilation system is a comparison between the observations and the model solution. The highly turbulent nature of core dynamics, along with the absence of any regular external forcing and constraint (which occurs in atmospheric dynamics, for example) means that short time comparisons (approx. 1000 years) cannot be made between model and observations. In order to make sensible comparisons, a direct insertion assimilation method has been implemented. In this approach, magnetic field observations at the Earth's surface have been substituted into the numerical model, such that the ratio of the multiple components and the dipole component from observation is adjusted at the core-mantle boundary and extended to the interior of the core, while the total magnetic energy remains unchanged. This adjusted magnetic field is then used as the initial field for a new simulation. In this way, a time tugged simulation is created which can then be compared directly with observations. We present numerical solutions with and without data insertion and discuss their implications for the development of a more rigorous assimilation system.

Keeping Enceladus Warm

NASA Astrophysics Data System (ADS)

Travis, B. J.; Schubert, G.

2012-12-01

Despite its small size, Enceladus emits considerable heat, especially at its south pole, even long after simple thermal models predict it should be frozen. A number of energy mechanisms have been proposed as responsible for this heating, such as TDH (tidal dissipative heating), and convection and shearing in the ice shell, but why energy outflow is primarily at the south pole is still debated. It is not known if TDH has operated continuously at Enceladus. Crater relaxation simulations suggest considerable heat flow has occurred over long stretches of its history. One process missing from previous models is fluid flow, both in an ocean layer and in the silicate core. The simulations described here are part of a study to estimate the impact of hydrothermal flow and to explore under what conditions, and for how long, an ocean layer could persist on Enceladus, with or without TDH. Our model geometry is 2-D spherical (radius and latitude) for most simulations, with one 3-D spherical simulation. We assume a silicate core of about 160 km radius, overlain by an H2O layer out to 250 km radius. Ice shell thickness is initially 15 km. Flow in an ocean layer is represented by a simplified Navier-Stokes model, and porous flow occurs in the core. Surface temperature distribution follows observed values. Radiogenic heating produces about 0.3 GW in the model. A simple TDH model is active in some simulations. Salts and/or NH3 may be present in the interior of Enceladus, and would strongly depress freezing; our model uses a low eutectic salt as an analog. The ice shell's thickness is not required to remain fixed, but can change dynamically, in response to local thermodynamics. Initial core temperature and permeability are unknowns. Initial core temperature is varied over several hundred oC, and permeability is varied over 1-100 millidarcies. In our simulations, typically, a flow field develops characterized by sinking flow at the equator and rising plumes at the poles. A broad thickening of ice in the equatorial region occurs, so much so that flow is gradually restricted to the polar regions, with the south pole flow stronger than at the northern pole. A feedback develops; cooler, sinking flow at the equator results in thickening of the ice there which in turn tends to isolate flow to the deeper ocean plus core region at the poles. The rate at which this pattern develops depends on the presence or absence of TDH. Except at the surface, a nearly cylindrical region from north to south through the model remains fluid. The presence of salt and/or NH3 allows liquid conditions and flow even as the ocean temperature falls well below 0 oC. At higher initial core temperatures, boiling occurs deep in the core because of the low overburden pressure. An approximately 70 km thick difference in ice thickness can develop between equator and poles. However, due to the low gravity of Enceladus, this would give rise to a buoyant pressure difference of only about 5 bars, which is less than shear strength measurements in ice. The core slowly cools, and eventually the ocean may freeze completely without TDH, but that can take on the order of several hundred million years or more. If episodes of strong TDH occurred on that time scale or shorter, a polar ocean might then persist indefinitely.

Characterization of Transcription from TATA-Less Promoters: Identification of a New Core Promoter Element XCPE2 and Analysis of Factor Requirements

PubMed Central

Anish, Ramakrishnan; Hossain, Mohammad B.; Jacobson, Raymond H.; Takada, Shinako

2009-01-01

Background More than 80% of mammalian protein-coding genes are driven by TATA-less promoters which often show multiple transcriptional start sites (TSSs). However, little is known about the core promoter DNA sequences or mechanisms of transcriptional initiation for this class of promoters. Methodology/Principal Findings Here we identify a new core promoter element XCPE2 (X core promoter element 2) (consensus sequence: A/C/G-C-C/T-C-G/A-T-T-G/A-C-C/A+1-C/T) that can direct specific transcription from the second TSS of hepatitis B virus X gene mRNA. XCPE2 sequences can also be found in human promoter regions and typically appear to drive one of the start sites within multiple TSS-containing TATA-less promoters. To gain insight into mechanisms of transcriptional initiation from this class of promoters, we examined requirements of several general transcription factors by in vitro transcription experiments using immunodepleted nuclear extracts and purified factors. Our results show that XCPE2-driven transcription uses at least TFIIB, either TFIID or free TBP, RNA polymerase II (RNA pol II) and the MED26-containing mediator complex but not Gcn5. Therefore, XCPE2-driven transcription can be carried out by a mechanism which differs from previously described TAF-dependent mechanisms for initiator (Inr)- or downstream promoter element (DPE)-containing promoters, the TBP- and SAGA (Spt-Ada-Gcn5-acetyltransferase)-dependent mechanism for yeast TATA-containing promoters, or the TFTC (TBP-free-TAF-containing complex)-dependent mechanism for certain Inr-containing TATA-less promoters. EMSA assays using XCPE2 promoter and purified factors further suggest that XCPE2 promoter recognition requires a set of factors different from those for TATA box, Inr, or DPE promoter recognition. Conclusions/Significance We identified a new core promoter element XCPE2 that are found in multiple TSS-containing TATA-less promoters. Mechanisms of promoter recognition and transcriptional initiation for XCPE2-driven promoters appear different from previously shown mechanisms for classical promoters that show single “focused” TSSs. Our studies provide insight into novel mechanisms of RNA Pol II transcription from multiple TSS-containing TATA-less promoters. PMID:19337366

Research on removing reservoir core water sensitivity using the method of ultrasound-chemical agent for enhanced oil recovery.

PubMed

Wang, Zhenjun; Huang, Jiehao

2018-04-01

The phenomenon of water sensitivity often occurs in the oil reservoir core during the process of crude oil production, which seriously affects the efficiency of oil extraction. In recent years, near-well ultrasonic processing technology attaches more attention due to its safety and energy efficient. In this paper, the comparison of removing core water sensitivity by ultrasonic wave, chemical injection and ultrasound-chemical combination technique are investigated through experiments. Results show that: lower ultrasonic frequency and higher power can improve the efficiency of core water sensitivity removal; the effects of removing core water sensitivity under ultrasonic treatment get better with increase of core initial permeability; the effect of removing core water sensitivity using ultrasonic treatment won't get better over time. Ultrasonic treatment time should be controlled in a reasonable range; the effect of removing core water sensitivity using chemical agent alone is slightly better than that using ultrasonic treatment, however, chemical injection could be replaced by ultrasonic treatment for removing core water sensitivity from the viewpoint of oil reservoir protection and the sustainable development of oil field; ultrasound-chemical combination technique has the best effect for water sensitivity removal than using ultrasonic treatment or chemical injection alone. Copyright © 2017 Elsevier B.V. All rights reserved.

Beta blocker infusion decreases the magnitude of core hypothermia after anesthesia induction.

PubMed

Inoue, S; Abe, R; Kawaguchi, M; Kobayashi, H; Furuya, H

2010-12-01

Beta-1-receptor blockade reduces heart rate, cardiac output, and arterial pressure while increasing peripheral vascular resistance. It is possible that beta blockers not only inhibit the core-to-peripheral re-distribution of body heat and cutaneous heat loss due to vasodilation after anesthesia induction but also reduce the convective transfer of heat from the core to peripheral tissues by decreasing cardiac output. The authors investigated whether the co-administration of esmolol or landiolol, ultra-short-acting beta blockers, attenuates the magnitude of initial re-distribution hypothermia after anesthesia induction and tracheal intubation. Immediately prior to the induction of anesthesia, patients were randomly assigned to receive 0.2 mg kg-1 of landiolol (landiolol group; N=30), 1 mg kg-1 of esmolol (esmolol group; N=30), or 0.1 mL kg-1 of saline (control group; N=30). Heart rate, blood pressure, cardiac output, and tympanic, forearm, and digit temperatures were recorded. Forearm minus fingertip skin-surface temperature gradients (temperature gradient) were calculated. Tympanic membrane temperatures 15 to 60 min after the induction of anesthesia were significantly higher in the esmolol group than in the control group although the temperature gradient was similar among the three groups. Both esmolol and landiolol inhibited the increase in HR and MAP after the induction of anesthesia and tracheal intubation. The cardiac index in the esmolol group was significantly lower than in the control group. The degree of hemodynamic attenuation after induction by esmolol was larger than that of landiolol. The co-administration of esmolol, but not landiolol, attenuated the magnitude of initial re-distribution hypothermia after anesthesia induction and tracheal intubation. Esmolol likely prevented initial hypothermia because it attenuated the convective transfer of heat from the core to peripheral tissues by decreasing cardiac output.

Numerical Study of Sound Emission by 2D Regular and Chaotic Vortex Configurations

NASA Astrophysics Data System (ADS)

Knio, Omar M.; Collorec, Luc; Juvé, Daniel

1995-02-01

The far-field noise generated by a system of three Gaussian vortices lying over a flat boundary is numerically investigated using a two-dimensional vortex element method. The method is based on the discretization of the vorticity field into a finite number of smoothed vortex elements of spherical overlapping cores. The elements are convected in a Lagrangian reference along particle trajectories using the local velocity vector, given in terms of a desingularized Biot-Savart law. The initial structure of the vortex system is triangular; a one-dimensional family of initial configurations is constructed by keeping one side of the triangle fixed and vertical, and varying the abscissa of the centroid of the remaining vortex. The inviscid dynamics of this vortex configuration are first investigated using non-deformable vortices. Depending on the aspect ratio of the initial system, regular or chaotic motion occurs. Due to wall-related symmetries, the far-field sound always exhibits a time-independent quadrupolar directivity with maxima parallel end perpendicular to the wall. When regular motion prevails, the noise spectrum is dominated by discrete frequencies which correspond to the fundamental system frequency and its superharmonics. For chaotic motion, a broadband spectrum is obtained; computed soundlevels are substantially higher than in non-chaotic systems. A more sophisticated analysis is then performed which accounts for vortex core dynamics. Results show that the vortex cores are susceptible to inviscid instability which leads to violent vorticity reorganization within the core. This phenomenon has little effect on the large-scale features of the motion of the system or on low frequency sound emission. However, it leads to the generation of a high-frequency noise band in the acoustic pressure spectrum. The latter is observed in both regular and chaotic system simulations.

Level 1 Tornado PRA for the High Flux Beam Reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bozoki, G.E.; Conrad, C.S.

This report describes a risk analysis primarily directed at providing an estimate for the frequency of tornado induced damage to the core of the High Flux Beam Reactor (HFBR), and thus it constitutes a Level 1 Probabilistic Risk Assessment (PRA) covering tornado induced accident sequences. The basic methodology of the risk analysis was to develop a ``tornado specific`` plant logic model that integrates the internal random hardware failures with failures caused externally by the tornado strike and includes operator errors worsened by the tornado modified environment. The tornado hazard frequency, as well as earlier prepared structural and equipment fragility data,more » were used as input data to the model. To keep modeling/calculational complexity as simple as reasonable a ``bounding`` type, slightly conservative, approach was applied. By a thorough screening process a single dominant initiating event was selected as a representative initiator, defined as: ``Tornado Induced Loss of Offsite Power.`` The frequency of this initiator was determined to be 6.37E-5/year. The safety response of the HFBR facility resulted in a total Conditional Core Damage Probability of .621. Thus, the point estimate of the HFBR`s Tornado Induced Core Damage Frequency (CDF) was found to be: (CDF){sub Tornado} = 3.96E-5/year. This value represents only 7.8% of the internal CDF and thus is considered to be a small contribution to the overall facility risk expressed in terms of total Core Damage Frequency. In addition to providing the estimate of (CDF){sub Tornado}, the report documents, the relative importance of various tornado induced system, component, and operator failures that contribute most to (CDF){sub Tornado}.« less

Age model for a continuous, ca 250-ka Quaternary lacustrine record from Bear Lake, Utah-Idaho

USGS Publications Warehouse

Colman, Steven M.; Kaufman, D.S.; Bright, Jordon; Heil, C.; King, J.W.; Dean, W.E.; Rosenbaum, J.G.; Forester, R.M.; Bischoff, J.L.; Perkins, Marie; McGeehin, J.P.

2006-01-01

The Quaternary sediments sampled by continuous 120-m-long drill cores from Bear Lake (Utah-Idaho) comprise one of the longest lacustrine sequences recovered from an extant lake. The cores serve as a good case study for the construction of an age model for sequences that extend beyond the range of radiocarbon dating. From a variety of potential age indicators, we selected a combination of radiocarbon ages, one magnetic excursion (correlated to a standard sequence), and a single Uranium-series age to develop an initial data set. The reliability of the excursion and U-series data require consideration of their position with respect to sediments of inferred interglacial character, but not direct correlation with other paleoclimate records. Data omitted from the age model include amino acid age estimates, which have a large amount of scatter, and tephrochronology correlations, which have relatively large uncertainties. Because the initial data set was restricted to the upper half of the BL00-1 core, we inferred additional ages by direct correlation to the independently dated paleoclimate record from Devils Hole. We developed an age model for the entire core using statistical methods that consider both the uncertainties of the original data and that of the curve-fitting process, with a combination of our initial data set and the climate correlations as control points. This age model represents our best estimate of the chronology of deposition in Bear Lake. Because the age model contains assumptions about the correlation of Bear Lake to other climate records, the model cannot be used to address some paleoclimate questions, such as phase relationships with other areas.

Longitudinal residual stresses in boron fibers

NASA Technical Reports Server (NTRS)

Behrendt, D. R.

1976-01-01

A method of measuring the longitudinal residual stress distribution in boron fibers is presented. The residual stresses in commercial CVD boron on tungsten fibers of 102, 142, and 203 microns (4, 5.6, and 8 mil) diameters were determined. Results for the three sizes show a compressive stress at the surface 800 to -1400 MN/sq m 120 to -200 ksi), changing monotonically to a region of tensile stress within the boron. At approximately 25 percent of the original radius, the stress reaches a maximum tensile 600 to 1000 MN/sq m(90 to 150 ksi) and then decreases to compressive near the tungsten boride core. The core itself is under a compressive stress of approximately -1300 MN/sq m (-190 ksi). The effects of surface removal on core residual stress and core-initiated fracture are discussed.

Core formation in the Moon: The mystery of the excess depletion of Mo, W and P

NASA Technical Reports Server (NTRS)

Newsom, H. E.; Maehr, S. A.

1993-01-01

We have evaluated siderophile element depletion models for the Moon in light of our improved statistical treatment of siderophile element abundance data and new information on the physics of core formation. If core formation occurred in the Moon at the large degrees of partial melting necessary for metal segregation, according to recent estimates, then a significant inconsistency (not seen in the eucrite parent body) exists in the depletion of the incompatible siderophile elements Mo, W, and P, compared to other siderophile elements in the Moon. The siderophile data, with the exception of Mo, are most consistent with terrestrial initial siderophile abundances and segregation of a very small core in the Moon. Our improved abundance estimates and possible explanations for these discrepancies are discussed.

The top of the Olduvai subchron in a high-resolution magnetostratigraphy from the West Turkana core WTK13, Hominin Sites and Paleolakes Drilling Project (HSPDP)

NASA Astrophysics Data System (ADS)

Sier, Mark; Langereis, Cor; Dupont-Nivet, Guillaume; Feibel, Craig; Jordeens, Jose; van der Lubbe, Jeroen; Beck, Catherine; Olago, Daniel; Cohen, Andrew

2017-04-01

One of the major challenges in understanding the evolution of our own species is identifying the role climate change has played in the evolution of earlier hominin species. To clarify the influence of climate, we need long and continuous high-resolution paleoclimate records, preferably obtained from hominin-bearing sediments, that are well-dated by tephro- and magnetostratigraphy and other methods. This is hindered, however, by the fact that fossil-bearing sediments are often discontinuous, and subject to weathering, which may lead to oxidation and remagnetization. To obtain fresh, unweathered sediments, the Hominin Sites and Paleolakes Drilling Project (HSPDP) collected a 216- meter core (WTK13) in 2013 from deposits of Early Pleistocene paleolake Lorenyang in the western Turkana Basin (Kenya). Here, we present the magnetostratigraphy of the core. Rock magnetic analyses reveal the presence of iron sulphides carrying the remanent magnetizations. To recover polarity orientation from the near-equatorial WTK13 core drilled at 5°N, we developed and successfully applied two independent drill-core reorientation methods taking advantage of (1) the sedimentary fabric as expressed in the Anisotropy of Magnetic Susceptibility (AMS) and (2) the occurrence of a viscous component oriented in the present day field. The reoriented directions reveal a normal to reversed polarity reversal identified as the top of the Olduvai subchron. From this excellent record, we find no evidence for the 'Vrica subchron' previously reported in the area. We suggest that outcrop-based interpretations supporting the presence of the Vrica subchron have been affected by the oxidation of iron sulphides initially present in the sediments as evident in the core record, and by subsequent remagnetization. Based on our new high-resolution magnetostratigraphy and stratigraphic markers, we provide constraints for an initial age model of the WTK13 core. We discuss the implications of the observed geomagnetic record for human evolution studies.

Investments in Professional Learning Must Change: The Goals Are Ambitious, the Stakes Are High--And Resources Are the Key

ERIC Educational Resources Information Center

Killion, Joellen; Hirsh, Stephanie

2013-01-01

Adapted from the brief "Meet the Promise of Content Standards: Investing in Professional Learning," this article draws on the work of Learning Forward's initiative, Transforming Professional Learning to Prepare College- and Career-Ready Students: Implementing the Common Core. This multidimensional initiative is focused on developing…

Large Scale Flutter Data for Design of Rotating Blades Using Navier-Stokes Equations

NASA Technical Reports Server (NTRS)

Guruswamy, Guru P.

2012-01-01

A procedure to compute flutter boundaries of rotating blades is presented; a) Navier-Stokes equations. b) Frequency domain method compatible with industry practice. Procedure is initially validated: a) Unsteady loads with flapping wing experiment. b) Flutter boundary with fixed wing experiment. Large scale flutter computation is demonstrated for rotating blade: a) Single job submission script. b) Flutter boundary in 24 hour wall clock time with 100 cores. c) Linearly scalable with number of cores. Tested with 1000 cores that produced data in 25 hrs for 10 flutter boundaries. Further wall-clock speed-up is possible by performing parallel computations within each case.

Swirl effect on flow structure and mixing in a turbulent jet

NASA Astrophysics Data System (ADS)

Kravtsov, Z. D.; Sharaborin, D. K.; Dulin, V. M.

2018-03-01

The paper reports on experimental study of turbulent transport in the initial region of swirling turbulent jets. The particle image velocimetry and planar laser-induced fluorescence techniques are used to investigate the flow structure and passive scalar concentration, respectively, in free air jet with acetone vapor. Three flow cases are considered, viz., non-swirling jets and swirling jets with and without vortex breakdown and central recirculation zone. Without vortex breakdown, the swirl is shown to promote jet mixing with surrounding air and to decrease the jet core length. The vortex core breakdown further enhances mixing as the jet core disintegrates at the nozzle exit.

Measuring the Internal Structure and Physical Conditions in Star and Planet Forming Clouds Cores: Towards a Quantitative Description of Cloud Evolution

NASA Technical Reports Server (NTRS)

Lada, Charles J.

2004-01-01

This grant funds a research program to use infrared extinction measurements to probe the detailed structure of dark molecular cloud cores and investigate the physical conditions which give rise to star and planet formation. The goals of this program are to acquire, reduce and analyze deep infrared and molecular-line observations of a carefully selected sample of nearby dark clouds in order to determine the detailed initial conditions for star formation from quantitative measurements of the internal structure of starless cloud cores and to quantitatively investigate the evolution of such structure through the star and planet formation process.

Rocky core solubility in Jupiter and giant exoplanets.

PubMed

Wilson, Hugh F; Militzer, Burkhard

2012-03-16

Gas giants are believed to form by the accretion of hydrogen-helium gas around an initial protocore of rock and ice. The question of whether the rocky parts of the core dissolve into the fluid H-He layers following formation has significant implications for planetary structure and evolution. Here we use ab initio calculations to study rock solubility in fluid hydrogen, choosing MgO as a representative example of planetary rocky materials, and find MgO to be highly soluble in H for temperatures in excess of approximately 10,000 K, implying the potential for significant redistribution of rocky core material in Jupiter and larger exoplanets.

Reinterpretation of the Burmester core, Bonneville basin, Utah

USGS Publications Warehouse

Oviatt, Charles G.; Thompson, R.S.; Kaufman, D.S.; Bright, Jordon; Forester, R.M.

1999-01-01

Initial interpretation of the sediments from the Burmester core (Eardley et al. (1973). Geological Society of America Bulletin 84, 211-216) indicated that 17 deep-lake cycles, separated by shallow-lake and soil-forming intervals, occurred in the Bonneville basin during the Brunhes Chron (the last 780 x 103 yr). Our re-examination of the core, along with new sedimentological, geochronological, and paleontological data, indicate that only four deep-lake cycles occurred during this period, apparently correlative with marine oxygen-isotope stages 2, 6, 12, and 16. This interpretation suggests that large lakes formed in the Bonneville basin only during the most extensive of the Northern Hemisphere glaciations.

Quiet Clean Short-haul Experimental Engine (QCSEE) Under-The-Wing (UTW) boiler plate nacelle and core exhaust nozzle design report

NASA Technical Reports Server (NTRS)

1976-01-01

The mechanical design of the boiler plate nacelle and core exhaust nozzle for the QCSEE under the wing engine is presented. The nacelle, which features interchangeable hard-wall and acoustic panels, is to be utilized in the initial engine testing to establish acoustic requirements for the subsequent composite nacelle as well as in the QCSEE over the wing engine configuration.

Pacific Northwest National Laboratory institutional plan: FY 1996--2001

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-01-01

This report contains the operation and direction plan for the Pacific Northwest National Laboratory of the US Department of Energy. The topics of the plan include the laboratory mission and core competencies, the laboratory strategic plan; the laboratory initiatives in molecular sciences, microbial biotechnology, global environmental change, complex modeling of physical systems, advanced processing technology, energy technology development, and medical technologies and systems; core business areas, critical success factors, and resource projections.

Soliton-plasma nonlinear dynamics in mid-IR gas-filled hollow-core fibers.

PubMed

Selim Habib, Md; Markos, Christos; Bang, Ole; Bache, Morten

2017-06-01

We investigate numerically soliton-plasma interaction in a noble-gas-filled silica hollow-core anti-resonant fiber pumped in the mid-IR at 3.0 μm. We observe multiple soliton self-compression stages due to distinct stages where either the self-focusing or the self-defocusing nonlinearity dominates. Specifically, the parameters may be tuned so the competing plasma self-defocusing nonlinearity only dominates over the Kerr self-focusing nonlinearity around the soliton self-compression stage, where the increasing peak intensity on the leading pulse edge initiates a competing self-defocusing plasma nonlinearity acting nonlocally on the trailing edge, effectively preventing soliton formation there. As the plasma switches off after the self-compression stage, self-focusing dominates again, initiating another soliton self-compression stage in the trailing edge. This process is accompanied by supercontinuum generation spanning 1-4 μm. We find that the spectral coherence drops as the secondary compression stage is initiated.

Out-of-core Evaluations of Uranium Nitride-fueled Converters

NASA Technical Reports Server (NTRS)

Shimada, K.

1972-01-01

Two uranium nitride fueled converters were tested parametrically for their initial characterization and are currently being life-tested out of core. Test method being employed for the parametric and the diagnostic measurements during the life tests, and test results are presented. One converter with a rhenium emitter had an initial output power density of 6.9 W/ sq cm at the black body emitter temperature of 1900 K. The power density remained unchanged for the first 1000 hr of life test but degraded nearly 50% percent during the following 1000 hr. Electrode work function measurements indicated that the uranium fuel was diffusing out of the emitter clad of 0.635 mm. The other converter with a tungsten emitter had an initial output power density of 2.2 W/ sq cm at 1900 K with a power density of 3.9 W/sq cm at 4300 h. The power density suddenly degraded within 20 hr to practically zero output at 4735 hr.

ROLE OF MAGNETIC FIELD STRENGTH AND NUMERICAL RESOLUTION IN SIMULATIONS OF THE HEAT-FLUX-DRIVEN BUOYANCY INSTABILITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Avara, Mark J.; Reynolds, Christopher S.; Bogdanovic, Tamara, E-mail: mavara@astro.umd.edu, E-mail: chris@astro.umd.edu, E-mail: tamarab@gatech.edu

2013-08-20

The role played by magnetic fields in the intracluster medium (ICM) of galaxy clusters is complex. The weakly collisional nature of the ICM leads to thermal conduction that is channeled along field lines. This anisotropic heat conduction profoundly changes the instabilities of the ICM atmosphere, with convective stabilities being driven by temperature gradients of either sign. Here, we employ the Athena magnetohydrodynamic code to investigate the local non-linear behavior of the heat-flux-driven buoyancy instability (HBI) relevant in the cores of cooling-core clusters where the temperature increases with radius. We study a grid of two-dimensional simulations that span a large rangemore » of initial magnetic field strengths and numerical resolutions. For very weak initial fields, we recover the previously known result that the HBI wraps the field in the horizontal direction, thereby shutting off the heat flux. However, we find that simulations that begin with intermediate initial field strengths have a qualitatively different behavior, forming HBI-stable filaments that resist field-line wrapping and enable sustained vertical conductive heat flux at a level of 10%-25% of the Spitzer value. While astrophysical conclusions regarding the role of conduction in cooling cores require detailed global models, our local study proves that systems dominated by the HBI do not necessarily quench the conductive heat flux.« less

Examination of core samples from the Mount Elbert Gas Hydrate Stratigraphic Test Well, Alaska North Slope: Effects of retrieval and preservation

USGS Publications Warehouse

Kneafsey, T.J.; Lu, H.; Winters, W.; Boswell, R.; Hunter, R.; Collett, T.S.

2011-01-01

Collecting and preserving undamaged core samples containing gas hydrates from depth is difficult because of the pressure and temperature changes encountered upon retrieval. Hydrate-bearing core samples were collected at the BPXA-DOE-USGS Mount Elbert Gas Hydrate Stratigraphic Test Well in February 2007. Coring was performed while using a custom oil-based drilling mud, and the cores were retrieved by a wireline. The samples were characterized and subsampled at the surface under ambient winter arctic conditions. Samples thought to be hydrate bearing were preserved either by immersion in liquid nitrogen (LN), or by storage under methane pressure at ambient arctic conditions, and later depressurized and immersed in LN. Eleven core samples from hydrate-bearing zones were scanned using x-ray computed tomography to examine core structure and homogeneity. Features observed include radial fractures, spalling-type fractures, and reduced density near the periphery. These features were induced during sample collection, handling, and preservation. Isotopic analysis of the methane from hydrate in an initially LN-preserved core and a pressure-preserved core indicate that secondary hydrate formation occurred throughout the pressurized core, whereas none occurred in the LN-preserved core, however no hydrate was found near the periphery of the LN-preserved core. To replicate some aspects of the preservation methods, natural and laboratory-made saturated porous media samples were frozen in a variety of ways, with radial fractures observed in some LN-frozen sands, and needle-like ice crystals forming in slowly frozen clay-rich sediments. Suggestions for hydrate-bearing core preservation are presented.

Core/shell silicon/polyaniline particles via in-flight plasma-induced polymerization

NASA Astrophysics Data System (ADS)

Yasar-Inceoglu, Ozgul; Zhong, Lanlan; Mangolini, Lorenzo

2015-08-01

Although silicon nanoparticles have potential applications in many relevant fields, there is often the need for post-processing steps to tune the property of the nanomaterial and to optimize it for targeted applications. In particular surface modification is generally necessary to both tune dispersibility of the particles in desired solvents to achieve optimal coating conditions, and to interface the particles with other materials to realize functional heterostructures. In this contribution we discuss the realization of core/shell silicon/polymer nanoparticles realized using a plasma-initiated in-flight polymerization process. Silicon particles are produced in a non-thermal plasma reactor using silane as a precursor. After synthesis they are aerodynamically injected into a second plasma reactor into which aniline vapor is introduced. The second plasma initiates the polymerization reactor leading to the formation of a 3-4 nm thick polymer shell surrounding the silicon core. The role of processing conditions on the properties of the polymeric shell is discussed. Preliminary results on the testing of this material as an anode for lithium ion batteries are presented.

Radiative shocks produced from spherical cryogenic implosions at the National Ignition Facility

DOE PAGES

Pak, A.; Divol, L.; Gregori, G.; ...

2013-05-20

Spherically expanding radiative shock waves have been observed from inertially confined implosion experiments at the National Ignition Facility. In these experiments, a spherical fusion target, initially 2 mm in diameter, is compressed via the pressure induced from the ablation of the outer target surface. At the peak compression of the capsule, x-ray and nuclear diagnostics indicate the formation of a central core, with a radius and ion temperature of ~20 μm and ~ 2 keV, respectively. This central core is surrounded by a cooler compressed shell of deuterium-tritium fuel that has an outer radius of ~40 μm and a densitymore » of >500 g/cm 3. Using inputs from multiple diagnostics, the peak pressure of the compressed core has been inferred to be of order 100 Gbar for the implosions discussed here. Furthermore, the shock front, initially located at the interface between the high pressure compressed fuel shell and surrounding in-falling low pressure ablator plasma, begins to propagate outwards after peak compression has been reached.« less

Heterogeneous Delivery of Silicate and Metal to the Earth via Large Planetesimals

NASA Astrophysics Data System (ADS)

Marchi, S.; Canup, R. M.; Walker, R. J.

2017-12-01

Earth's mantle abundances of at least some highly siderophile elements, (HSE; Re, Os, Ir, Ru, Pt, Rh, Pd, and Au), are much higher than would result from metal-silicate equilibration during terrestrial core formation, and can be better explained as a result of late accretion of a minimum of 0.5% Earth's masses after core formation was complete. Traditional models assume that HSEs delivered by late projectiles completely mixed and chemically equilibrated with the Earth's mantle. This appears likely for undifferentiated, well-mixed projectiles, or for relatively small, differentiated projectiles. However several arguments suggest that late projectiles may have been large (> 1500 km in diameter) and differentiated, and in this case, portions of the projectile's core may merge with the Earth's core, rather than being mixed into the Earth's mantle. We investigate projectile mixing with a suite of SPH simulations of differentiated planetesimal colliding with the Earth. A range of outcomes emerge from our simulations suggesting that for large impactors (>1500 km), the delivery of HSE to the Earth's mantle may be disproportionate with the overall delivery of mass. For impacts with impact angles < 45° , between ˜ 20% to 80% of the impactor's core may merge directly with the Earth's core; while for impact angle > 60°, most of the impactor core escapes for moderate impact speeds. An implication is that the late accreted mass inferred from terrestrial HSE abundances may be a substantial underestimate, by a factor 2-5. In addition, partial mixing of projectiles result in an enrichment in mantle vs core material delivered to the bulk silicate Earth, implying substantial compositional variations in the accreted mass. Such variations could produce initially localized domains in Earth's mantle with distinct, mass independent isotopic signatures, given the isotopic variability resulting from nucleosynthetic heterogeneities among genetically diverse meteorites. In general we find that larger, low angle collisions would be more likely to produce initial mantle domains of anomalous composition material. We discuss the implications of these findings in the light of isotopic anomalies (e.g. W) in ancient terrestrial rocks.

Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature

PubMed Central

Yılmaz, Hasan; Yavuz, Ufuk; Üstüner, Murat; Çiftçi, Seyfettin; Yaşar, Hikmet; Müezzinoğlu, Bahar; Uslubaş, Ali Kemal; Dillioğlugil, Özdal

2017-01-01

Objective Only a few papers in the literature aimed to evaluate biopsy core lengths. Additionally, studies evaluated the core length with different approaches. We aimed to determine whether prostate cancer (PCa) detection is affected from core lengths according to three different approaches in a large standard cohort and compare our cut-off values with the published cut-offs. Material and methods We retrospectively analyzed 1,523 initial consecutive transrectal ultrasound-guided 12-core prostate biopsies. Biopsies were evaluated with respect to total core length (total length of each patients’ core) average core length (total core length divided by total number of cores in each patient), and mean core length (mean length of all cores pooled), and compared our cut-off values with the published cut-offs. The prostate volumes were categorized into four groups (<30, 30–59.99, 60–119.99, ≥120 cm3) and PCa detection rates in these categories were examined. Results PCa was found in 41.5% patients. There was no difference between benign and malignant mean core lengths of the pooled cores (p>0.05). Total core length and average core length were not significantly associated with PCa in multivariate logistic regression analyses (p>0.05). The core lengths (mean, average and total core lengths) increased (p<0.001) and PCa rates decreased (p<0.001) steadily with increasing prostate volume categories. PCa percentages decreased in all categories above the utilized cut-offs for mean (p>0.05), average (p<0.05), and total core lengths (p>0.05). Conclusion There was no difference between mean core lengths of benign and malignant cores. Total core length and average core length were not significantly associated with PCa. Contrary to the cut-offs used for mean and average core lengths in the published studies, PCa rates decrease as these core lengths increase. Larger studies are necessary for the determination and acceptance of accurate cut-offs. PMID:28861301

Top-down freezing in a Fe-FeS core and Ganymede's present-day magnetic field

NASA Astrophysics Data System (ADS)

Rückriemen, Tina; Breuer, Doris; Spohn, Tilman

2018-06-01

Ganymede's core most likely possesses an active dynamo today, which produces a magnetic field at the surface of ∼ 719 nT. Thermochemical convection triggered by cooling of the core is a feasible power source for the dynamo. Experiments of different research groups indicate low pressure gradients of the melting temperatures for Fe-FeS core alloys at pressures prevailing in Ganymede's core ( < 10 GPa). This may entail that the core crystallizes from the top instead of from the bottom as is expected for Earth's core. Depending on the core sulfur concentration being more iron- or more sulfur-rich than the eutectic concentration either snowing iron crystals or a solid FeS layer can form at the top of the core. We investigate whether these two core crystallization scenarios are capable of explaining Ganymede's present magnetic activity. To do so, we set up a parametrized one-dimensional thermal evolution model. We explore a wide range of parameters by running a large set of Monte Carlo simulations. Both freezing scenarios can explain Ganymede's present-day magnetic field. Dynamos of iron snow models are rather young ( < 1 Gyr), whereas dynamos below the FeS layer can be both young and much older ( ∼ 3.8 Gyr). Successful models preferably contain less radiogenic heat sources in the mantle than the chondritic abundance and show a correlation between the reference viscosity in the mantle and the initial core sulfur concentration.

The Interplay between Proto--Neutron Star Convection and Neutrino Transport in Core-Collapse Supernovae

NASA Astrophysics Data System (ADS)

Mezzacappa, A.; Calder, A. C.; Bruenn, S. W.; Blondin, J. M.; Guidry, M. W.; Strayer, M. R.; Umar, A. S.

1998-01-01

We couple two-dimensional hydrodynamics to realistic one-dimensional multigroup flux-limited diffusion neutrino transport to investigate proto-neutron star convection in core-collapse supernovae, and more specifically, the interplay between its development and neutrino transport. Our initial conditions, time-dependent boundary conditions, and neutrino distributions for computing neutrino heating, cooling, and deleptonization rates are obtained from one-dimensional simulations that implement multigroup flux-limited diffusion and one-dimensional hydrodynamics. The development and evolution of proto-neutron star convection are investigated for both 15 and 25 M⊙ models, representative of the two classes of stars with compact and extended iron cores, respectively. For both models, in the absence of neutrino transport, the angle-averaged radial and angular convection velocities in the initial Ledoux unstable region below the shock after bounce achieve their peak values in ~20 ms, after which they decrease as the convection in this region dissipates. The dissipation occurs as the gradients are smoothed out by convection. This initial proto-neutron star convection episode seeds additional convectively unstable regions farther out beneath the shock. The additional proto-neutron star convection is driven by successive negative entropy gradients that develop as the shock, in propagating out after core bounce, is successively strengthened and weakened by the oscillating inner core. The convection beneath the shock distorts its sphericity, but on the average the shock radius is not boosted significantly relative to its radius in our corresponding one-dimensional models. In the presence of neutrino transport, proto-neutron star convection velocities are too small relative to bulk inflow velocities to result in any significant convective transport of entropy and leptons. This is evident in our two-dimensional entropy snapshots, which in this case appear spherically symmetric. The peak angle-averaged radial and angular convection velocities are orders of magnitude smaller than they are in the corresponding ``hydrodynamics-only'' models. A simple analytical model supports our numerical results, indicating that the inclusion of neutrino transport reduces the entropy-driven (lepton-driven) convection growth rates and asymptotic velocities by a factor ~3 (50) at the neutrinosphere and a factor ~250 (1000) at ρ = 1012 g cm-3, for both our 15 and 25 M⊙ models. Moreover, when transport is included, the initial postbounce entropy gradient is smoothed out by neutrino diffusion, whereas the initial lepton gradient is maintained by electron capture and neutrino escape near the neutrinosphere. Despite the maintenance of the lepton gradient, proto-neutron star convection does not develop over the 100 ms duration typical of all our simulations, except in the instance where ``low-test'' intial conditions are used, which are generated by core-collapse and bounce simulations that neglect neutrino-electron scattering and ion-ion screening corrections to neutrino-nucleus elastic scattering. Models favoring the development of proto-neutron star convection either by starting with more favorable, albeit artificial (low-test), initial conditions or by including transport corrections that were ignored in our ``fiducial'' models were considered. Our conclusions nonetheless remained the same. Evidence of proto-neutron star convection in our two-dimensional entropy snapshots was minimal, and, as in our fiducial models, the angle-averaged convective velocities when neutrino transport was included remained orders of magnitude smaller than their counterparts in the corresponding hydrodynamics-only models.

DART Core/Combustor-Noise Initial Test Results

NASA Technical Reports Server (NTRS)

Boyle, Devin K.; Henderson, Brenda S.; Hultgren, Lennart S.

2017-01-01

Contributions from the combustor to the overall propulsion noise of civilian transport aircraft are starting to become important due to turbofan design trends and advances in mitigation of other noise sources. Future propulsion systems for ultra-efficient commercial air vehicles are projected to be of increasingly higher bypass ratio from larger fans combined with much smaller cores, with ultra-clean burning fuel-flexible combustors. Unless effective noise-reduction strategies are developed, combustor noise is likely to become a prominent contributor to overall airport community noise in the future. The new NASA DGEN Aero0propulsion Research Turbofan (DART) is a cost-efficient testbed for the study of core-noise physics and mitigation. This presentation gives a brief description of the recently completed DART core combustor-noise baseline test in the NASA GRC Aero-Acoustic Propulsion Laboratory (AAPL). Acoustic data was simultaneously acquired using the AAPL overhead microphone array in the engine aft quadrant far field, a single midfield microphone, and two semi-infinite-tube unsteady pressure sensors at the core-nozzle exit. An initial assessment shows that the data is of high quality and compares well with results from a quick 2014 feasibility test. Combustor noise components of measured total-noise signatures were educed using a two-signal source-separation method an dare found to occur in the expected frequency range. The research described herein is aligned with the NASA Ultra-Efficient Commercial Transport strategic thrust and is supported by the NASA Advanced Air Vehicle Program, Advanced Air Transport Technology Project, under the Aircraft Noise Reduction Subproject.

Initial results from geophysical surveys and shallow coring of the Northeast Greenland Ice Stream (NEGIS)

NASA Astrophysics Data System (ADS)

Vallelonga, P.; Christianson, K.; Alley, R. B.; Anandakrishnan, S.; Christian, J. E. M.; Dahl-Jensen, D.; Gkinis, V.; Holme, C.; Jacobel, R. W.; Karlsson, N.; Keisling, B. A.; Kipfstuhl, S.; Kjær, H. A.; Kristensen, M. E. L.; Muto, A.; Peters, L. E.; Popp, T.; Riverman, K. L.; Svensson, A. M.; Tibuleac, C.; Vinther, B. M.; Weng, Y.; Winstrup, M.

2014-01-01

The Northeast Greenland Ice Stream (NEGIS) is the sole interior Greenlandic ice stream. Fast flow initiates near the summit dome, and the ice stream terminates approximately 1000 km downstream in three large outlet glaciers that calve into the Greenland Sea. To better understand this important system, in the summer of 2012 we drilled a 67 m firn core and conducted ground-based radio-echo sounding (RES) and active-source seismic surveys at a site approximately 150 km downstream from the onset of streaming flow (NEGIS firn core, 75° 37.61' N, 35°56.49' W). The site is representative of the upper part of the ice stream, while also being in a crevasse-free area for safe surface operations. Annual cycles were observed for insoluble dust, sodium and ammonium concentrations and for electrolytic conductivity, allowing a seasonally resolved chronology covering the past 400 yr. Annual layer thicknesses averaged 0.11 m ice equivalent (i.e.) for the period 1607-2011, although accumulation varied between 0.08 and 0.14 m i.e., likely due to flow-related changes in surface topography. Tracing of RES layers from the NGRIP ice core site shows that the ice at NEGIS preserves a climatic record of at least the past 51 kyr. We demonstrate that a deep ice core drilling in this location can provide a reliable Holocene and late-glacial climate record, as well as helping to constrain the past dynamics and ice-lithosphere interactions of the Greenland Ice Sheet.

The Driving Magnetic Field and Reconnection in CME/Flare Eruptions and Coronal Jets

NASA Technical Reports Server (NTRS)

Moore, Ronald L.

2010-01-01

Signatures of reconnection in major CME (coronal mass ejection)/flare eruptions and in coronal X-ray jets are illustrated and interpreted. The signatures are magnetic field lines and their feet that brighten in flare emission. CME/flare eruptions are magnetic explosions in which: 1. The field that erupts is initially a closed arcade. 2. At eruption onset, most of the free magnetic energy to be released is not stored in field bracketing a current sheet, but in sheared field in the core of the arcade. 3. The sheared core field erupts by a process that from its start or soon after involves fast "tether-cutting" reconnection at an initially small current sheet low in the sheared core field. If the arcade has oppositely-directed field over it, the eruption process from its start or soon after also involves fast "breakout" reconnection at an initially small current sheet between the arcade and the overarching field. These aspects are shown by the small area of the bright field lines and foot-point flare ribbons in the onset of the eruption. 4. At either small current sheet, the fast reconnection progressively unleashes the erupting core field to erupt with progressively greater force. In turn, the erupting core field drives the current sheet to become progressively larger and to undergo progressively greater fast reconnection in the explosive phase of the eruption, and the flare arcade and ribbons grow to become comparable to the pre-eruption arcade in lateral extent. In coronal X-ray jets: 1. The magnetic energy released in the jet is built up by the emergence of a magnetic arcade into surrounding unipolar "open" field. 2. A simple jet is produced when a burst of reconnection occurs at the current sheet between the arcade and the open field. This produces a bright reconnection jet and a bright reconnection arcade that are both much smaller in diameter that the driving arcade. 3. A more complex jet is produced when the arcade has a sheared core field and undergoes an ejective eruption in the manner of a miniature CME/flare eruption. The jet is then a combination of a miniature CME and the products of more widely distributed reconnection of the erupting arcade with the open field than in simple jets.

Arthroscopic-assisted core decompression of the humeral head.

PubMed

Dines, Joshua S; Strauss, Eric J; Fealy, Stephen; Craig, Edward V

2007-01-01

Humeral head osteonecrosis is a progressive disease that requires prompt diagnosis and treatment. Core decompression is a viable treatment option for early-stage cases. Most surgeons perform core decompression by arthroscopically visualizing the necrotic area of bone and using a cannulated drill to take a core. Several attempts are frequently needed to reach the proper location. In the hip multiple passes are associated with complications. We describe the use of an anterior cruciate ligament (ACL) tibial drill guide to precisely localize the area of necrotic bone. Diagnostic arthroscopy is performed to assess the areas of osteonecrosis. Core decompression is performed by use of an ACL tibial guide, brought in through the anterior or posterior portal to precisely localize the necrotic area in preparation for drilling. Under image intensification, Steinmann pins are advanced into the area of osteonecrosis. Once positioned, several 4-mm cores are made. We treated 3 patients with this technique, and all had immediate pain relief. The use of the ACL guide allows precise localization of the area of humeral head involvement and avoids multiple drillings into unaffected areas. Initial indications are that arthroscopic-assisted core decompression with an ACL guide is an effective alternative to previously used methods.

Best estimate plus uncertainty analysis of departure from nucleate boiling limiting case with CASL core simulator VERA-CS in response to PWR main steam line break event

DOE PAGES

Brown, Cameron S.; Zhang, Hongbin; Kucukboyaci, Vefa; ...

2016-09-07

VERA-CS (Virtual Environment for Reactor Applications, Core Simulator) is a coupled neutron transport and thermal-hydraulics subchannel code under development by the Consortium for Advanced Simulation of Light Water Reactors (CASL). VERA-CS was used to simulate a typical pressurized water reactor (PWR) full core response with 17x17 fuel assemblies for a main steam line break (MSLB) accident scenario with the most reactive rod cluster control assembly stuck out of the core. The accident scenario was initiated at the hot zero power (HZP) at the end of the first fuel cycle with return to power state points that were determined by amore » system analysis code and the most limiting state point was chosen for core analysis. The best estimate plus uncertainty (BEPU) analysis method was applied using Wilks’ nonparametric statistical approach. In this way, 59 full core simulations were performed to provide the minimum departure from nucleate boiling ratio (MDNBR) at the 95/95 (95% probability with 95% confidence level) tolerance limit. The results show that this typical PWR core remains within MDNBR safety limits for the MSLB accident.« less

Best estimate plus uncertainty analysis of departure from nucleate boiling limiting case with CASL core simulator VERA-CS in response to PWR main steam line break event

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Cameron S.; Zhang, Hongbin; Kucukboyaci, Vefa

VERA-CS (Virtual Environment for Reactor Applications, Core Simulator) is a coupled neutron transport and thermal-hydraulics subchannel code under development by the Consortium for Advanced Simulation of Light Water Reactors (CASL). VERA-CS was used to simulate a typical pressurized water reactor (PWR) full core response with 17x17 fuel assemblies for a main steam line break (MSLB) accident scenario with the most reactive rod cluster control assembly stuck out of the core. The accident scenario was initiated at the hot zero power (HZP) at the end of the first fuel cycle with return to power state points that were determined by amore » system analysis code and the most limiting state point was chosen for core analysis. The best estimate plus uncertainty (BEPU) analysis method was applied using Wilks’ nonparametric statistical approach. In this way, 59 full core simulations were performed to provide the minimum departure from nucleate boiling ratio (MDNBR) at the 95/95 (95% probability with 95% confidence level) tolerance limit. The results show that this typical PWR core remains within MDNBR safety limits for the MSLB accident.« less

Constraints on core-collapse supernova progenitors from explosion site integral field spectroscopy

NASA Astrophysics Data System (ADS)

Kuncarayakti, H.; Anderson, J. P.; Galbany, L.; Maeda, K.; Hamuy, M.; Aldering, G.; Arimoto, N.; Doi, M.; Morokuma, T.; Usuda, T.

2018-05-01

Context. Observationally, supernovae (SNe) are divided into subclasses according to their distinct characteristics. This diversity naturally reflects the diversity in the progenitor stars. It is not entirely clear, however, how different evolutionary paths leading massive stars to become an SN are governed by fundamental parameters such as progenitor initial mass and metallicity. Aims: This paper places constraints on progenitor initial mass and metallicity in distinct core-collapse SN subclasses through a study of the parent stellar populations at the explosion sites. Methods: Integral field spectroscopy (IFS) of 83 nearby SN explosion sites with a median distance of 18 Mpc has been collected and analysed, enabling detection and spectral extraction of the parent stellar population of SN progenitors. From the parent stellar population spectrum, the initial mass and metallicity of the coeval progenitor are derived by means of comparison to simple stellar population models and strong-line methods. Additionally, near-infrared IFS was employed to characterise the star formation history at the explosion sites. Results: No significant metallicity differences are observed among distinct SN types. The typical progenitor mass is found to be highest for SN type Ic, followed by type Ib, then types IIb and II. Type IIn is the least associated with young stellar populations and thus massive progenitors. However, statistically significant differences in progenitor initial mass are observed only when comparing SNe IIn with other subclasses. Stripped-envelope SN progenitors with initial mass estimates lower than 25 M⊙ are found; they are thought to be the result of binary progenitors. Confirming previous studies, these results support the notion that core-collapse SN progenitors cannot arise from single-star channels only, and both single and binary channels are at play in the production of core-collapse SNe. Near-infrared IFS suggests that multiple stellar populations with different ages may be present in some of the SN sites. As a consequence, there could be a non-negligible amount of contamination from old populations, and therefore the individual age estimates are effectively lower limits. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programmes 089.D-0367, 091.D-0482, 093.D-0318, 094.D-0290, and 095.D-0172

Crystallization of a compositionally stratified basal magma ocean

NASA Astrophysics Data System (ADS)

Laneuville, Matthieu; Hernlund, John; Labrosse, Stéphane; Guttenberg, Nicholas

2018-03-01

Earth's ∼3.45 billion year old magnetic field is regenerated by dynamo action in its convecting liquid metal outer core. However, convection induces an isentropic thermal gradient which, coupled with a high core thermal conductivity, results in rapid conducted heat loss. In the absence of implausibly high radioactivity or alternate sources of motion to drive the geodynamo, the Earth's early core had to be significantly hotter than the melting point of the lower mantle. While the existence of a dense convecting basal magma ocean (BMO) has been proposed to account for high early core temperatures, the requisite physical and chemical properties for a BMO remain controversial. Here we relax the assumption of a well-mixed convecting BMO and instead consider a BMO that is initially gravitationally stratified owing to processes such as mixing between metals and silicates at high temperatures in the core-mantle boundary region during Earth's accretion. Using coupled models of crystallization and heat transfer through a stratified BMO, we show that very high temperatures could have been trapped inside the early core, sequestering enough heat energy to run an ancient geodynamo on cooling power alone.

Controlled Synthesis of Pd/Pt Core Shell Nanoparticles Using Area-selective Atomic Layer Deposition

PubMed Central

Cao, Kun; Zhu, Qianqian; Shan, Bin; Chen, Rong

2015-01-01

We report an atomic scale controllable synthesis of Pd/Pt core shell nanoparticles (NPs) via area-selective atomic layer deposition (ALD) on a modified surface. The method involves utilizing octadecyltrichlorosilane (ODTS) self-assembled monolayers (SAMs) to modify the surface. Take the usage of pinholes on SAMs as active sites for the initial core nucleation, and subsequent selective deposition of the second metal as the shell layer. Since new nucleation sites can be effectively blocked by surface ODTS SAMs in the second deposition stage, we demonstrate the successful growth of Pd/Pt and Pt/Pd NPs with uniform core shell structures and narrow size distribution. The size, shell thickness and composition of the NPs can be controlled precisely by varying the ALD cycles. Such core shell structures can be realized by using regular ALD recipes without special adjustment. This SAMs assisted area-selective ALD method of core shell structure fabrication greatly expands the applicability of ALD in fabricating novel structures and can be readily applied to the growth of NPs with other compositions. PMID:25683469

A Numerical Study on the Edgewise Compression Strength of Sandwich Structures with Facesheet-Core Disbonds

NASA Technical Reports Server (NTRS)

Bergan, Andrew C.

2017-01-01

Damage tolerant design approaches require determination of critical damage modes and flaw sizes in order to establish nondestructive evaluation detection requirements. A finite element model is developed to assess the effect of circular facesheet-core disbonds on the strength of sandwich specimens subjected to edgewise compressive loads for the purpose of predicting the critical flaw size for a variety of design parameters. Postbuckling analyses are conducted in which an initial imperfection is seeded using results from a linear buckling analysis. Both the virtual crack closure technique (VCCT) and cohesive elements are considered for modeling disbond growth. Predictions from analyses using the VCCT and analyses using cohesive elements are in good correlation. A series of parametric analyses are conducted to investigate the effect of core thickness and material, facesheet layup, facesheet-core interface properties, and curvature on the criticality of facesheet-core disbonds of various sizes. The results from these analyses provide a basis for determining the critical flaw size for facesheet-core disbonds subjected to edgewise compression loads and, therefore, nondestructive evaluation flaw detection requirements for this configuration.

The Aquila prestellar core population revealed by Herschel

NASA Astrophysics Data System (ADS)

Könyves, V.; André, Ph.; Men'shchikov, A.; Schneider, N.; Arzoumanian, D.; Bontemps, S.; Attard, M.; Motte, F.; Didelon, P.; Maury, A.; Abergel, A.; Ali, B.; Baluteau, J.-P.; Bernard, J.-Ph.; Cambrésy, L.; Cox, P.; di Francesco, J.; di Giorgio, A. M.; Griffin, M. J.; Hargrave, P.; Huang, M.; Kirk, J.; Li, J. Z.; Martin, P.; Minier, V.; Molinari, S.; Olofsson, G.; Pezzuto, S.; Russeil, D.; Roussel, H.; Saraceno, P.; Sauvage, M.; Sibthorpe, B.; Spinoglio, L.; Testi, L.; Ward-Thompson, D.; White, G.; Wilson, C. D.; Woodcraft, A.; Zavagno, A.

2010-07-01

The origin and possible universality of the stellar initial mass function (IMF) is a major issue in astrophysics. One of the main objectives of the Herschel Gould Belt Survey is to clarify the link between the prestellar core mass function (CMF) and the IMF. We present and discuss the core mass function derived from Herschel data for the large population of prestellar cores discovered with SPIRE and PACS in the Aquila rift cloud complex at d ~ 260 pc. We detect a total of 541 starless cores in the entire ~11 deg2 area of the field imaged at 70-500 μm with SPIRE/PACS. Most of these cores appear to be gravitationally bound, and thus prestellar in nature. Our Herschel results confirm that the shape of the prestellar CMF resembles the stellar IMF, with much higher quality statistics than earlier submillimeter continuum ground-based surveys. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from ASA.Figures 3-6 are only available in electronic format at http://www.aanda.org

Transformation of Au144(SCH2CH2Ph)60 to Au133(SPh-tBu)52 Nanomolecules: Theoretical and Experimental Study.

PubMed

Nimmala, Praneeth Reddy; Theivendran, Shevanuja; Barcaro, Giovanni; Sementa, Luca; Kumara, Chanaka; Jupally, Vijay Reddy; Apra, Edoardo; Stener, Mauro; Fortunelli, Alessandro; Dass, Amala

2015-06-04

Ultrastable gold nanomolecule Au144(SCH2CH2Ph)60 upon etching with excess tert-butylbenzenethiol undergoes a core-size conversion and compositional change to form an entirely new core of Au133(SPh-tBu)52. This conversion was studied using high-resolution electrospray mass spectrometry which shows that the core size conversion is initiated after 22 ligand exchanges, suggesting a relatively high stability of the Au144(SCH2CH2Ph)38(SPh-tBu)22 intermediate. The Au144 → Au133 core size conversion is surprisingly different from the Au144 → Au99 core conversion reported in the case of thiophenol, -SPh. Theoretical analysis and ab initio molecular dynamics simulations show that rigid p-tBu groups play a crucial role by reducing the cluster structural freedom, and protecting the cluster from adsorption of exogenous and reactive species, thus rationalizing the kinetic factors that stabilize the Au133 core size. This 144-atom to 133-atom nanomolecule's compositional change is reflected in optical spectroscopy and electrochemistry.

Restricted Closed Shell Hartree Fock Roothaan Matrix Method Applied to Helium Atom Using Mathematica

ERIC Educational Resources Information Center

Acosta, César R.; Tapia, J. Alejandro; Cab, César

2014-01-01

Slater type orbitals were used to construct the overlap and the Hamiltonian core matrices; we also found the values of the bi-electron repulsion integrals. The Hartree Fock Roothaan approximation process starts with setting an initial guess value for the elements of the density matrix; with these matrices we constructed the initial Fock matrix.…

Environmental Fate and Biological Consequences of Chemicals Related to Air Force Activities

DTIC Science & Technology

1982-09-01

milliliters of a 10% solution over a 78.5-square centimeter surface. Sample treated cores were tested under laboratory conditions and in field studies and using...natural weather conditions for comparative tests. No Sig- nificant differences were noted between field and laboratory conditions . Biological...JP-4- and JP-5-dosed cores initially show a stressed condition as indicated by an increased rate in CO2 produc- tion followed by a rate of CO2

Evaluating ethics competence in medical education.

PubMed Central

Savulescu, J; Crisp, R; Fulford, K W; Hope, T

1999-01-01

We critically evaluate the ways in which competence in medical ethics has been evaluated. We report the initial stage in the development of a relevant, reliable and valid instrument to evaluate core critical thinking skills in medical ethics. This instrument can be used to evaluate the impact of medical ethics education programmes and to assess whether medical students have achieved a satisfactory level of performance of core skills and knowledge in medical ethics, within and across institutions. PMID:10536759

Theoretical Developments in Understanding Massive Star Formation

NASA Technical Reports Server (NTRS)

Yorke, Harold W.; Bodenheimer, Peter

2007-01-01

Except under special circumstances massive stars in galactic disks will form through accretion. The gravitational collapse of a molecular cloud core will initially produce one or more low mass quasi-hydrostatic objects of a few Jupiter masses. Through subsequent accretion the masses of these cores grow as they simultaneously evolve toward hydrogen burning central densities and temperatures. We review the evolution of accreting (proto-)stars, including new results calculated with a publicly available stellar evolution code written by the authors.

Etching-dependent fluorescence quenching of Ag-dielectric-Au three-layered nanoshells: The effect of inner Ag nanosphere

NASA Astrophysics Data System (ADS)

Zhu, Jian; Xu, Zai-jie; Weng, Guo-jun; Zhao, Jing; Li, Jian-jun; Zhao, Jun-wu

2018-07-01

In this report, Ag-dielectric-Au three-layered nanoshells with controlled inner core size were synthesized. The fluorescence emission of the rhodamine 6G (R6G) could be quenched by the three-layered nanoshells distinctly. What's more, the fluorescence quenching efficiency could be further improved by tuning the etching of inner Ag nanosphere. The maximum fluorescence quenching efficiency is obtained when the separate layer just appears between the inner Ag core and the outer Au shell. Whereas the fluorescence quenching efficiency is weakened when no gaps take place around the inner Ag core or the separate layer is too thick and greater than 13 nm. The fluorescence quenching properties of the Ag-dielectric-Au three-layered nanoshells with different initial sizes of the Ag nanoparticles are also studied. The maximum fluorescence quenching efficiency is obtained when the three-layered nanoshells are synthesized based on the Ag nanoparticles with 60 nm, which is better than others two sizes (42 and 79 nm). Thus we believe that the size of initial Ag nanospheres also greatly affects the optimized fluorescence quenching efficiency. These results about fluorescence quenching properties of Ag-dielectric-Au three-layered nanoshells present a potential for design and fabrication of fluorescence nanosensors based on tuning the geometry of the inner core and the separate layer.

Evaluation of HFIR LEU Fuel Using the COMSOL Multiphysics Platform

DOE Office of Scientific and Technical Information (OSTI.GOV)

Primm, Trent; Ruggles, Arthur; Freels, James D

2009-03-01

A finite element computational approach to simulation of the High Flux Isotope Reactor (HFIR) Core Thermal-Fluid behavior is developed. These models were developed to facilitate design of a low enriched core for the HFIR, which will have different axial and radial flux profiles from the current HEU core and thus will require fuel and poison load optimization. This report outlines a stepwise implementation of this modeling approach using the commercial finite element code, COMSOL, with initial assessment of fuel, poison and clad conduction modeling capability, followed by assessment of mating of the fuel conduction models to a one dimensional fluidmore » model typical of legacy simulation techniques for the HFIR core. The model is then extended to fully couple 2-dimensional conduction in the fuel to a 2-dimensional thermo-fluid model of the coolant for a HFIR core cooling sub-channel with additional assessment of simulation outcomes. Finally, 3-dimensional simulations of a fuel plate and cooling channel are presented.« less

The synthesis of four-layer gold-silver-polymer-silver core-shell nanomushroom with inbuilt Raman molecule for surface-enhanced Raman scattering

NASA Astrophysics Data System (ADS)

Jiang, Tao; Wang, Xiaolong; Zhou, Jun

2017-12-01

A facial two-step reduction method was proposed to synthesize four-layer gold-silver-polymer-silver (Au@Ag@PSPAA@Ag) core-shell nanomushrooms (NMs) with inbuilt Raman molecule. The surface-enhanced Raman scattering (SERS) intensity of 4MBA adhered on the surface of Au core gradually increased with the modification of middle Ag shell and then Ag mushroom cap due to the formation of two kinds of ultra-small interior nanogap. Compared with the initial Au nanoparticles, the SERS enhancement ratio of the Au@Ag@PSPAA@Ag NMs approached to nearly 40. The novel core-shell NMs also exhibited homogeneous SERS signals for only one sample and reproducible signals for 10 different samples, certified by the low relative standard deviation values of less than 10% and 15% for the character peaks of 4-mercaptobenzoic acid, respectively. Such a novel four-layer core-shell nanostructure with reliable SERS performance has great potential application in quantitative SERS-based immunoassay.

Hydrodynamical simulations of the stream-core interaction in the slow merger of massive stars

NASA Astrophysics Data System (ADS)

Ivanova, N.; Podsiadlowski, Ph.; Spruit, H.

2002-08-01

We present detailed simulations of the interaction of a stream emanating from a mass-losing secondary with the core of a massive supergiant in the slow merger of two stars inside a common envelope. The dynamics of the stream can be divided into a ballistic phase, starting at the L1 point, and a hydrodynamical phase, where the stream interacts strongly with the core. Considering the merger of a 1- and 5-Msolar star with a 20-Msolar evolved supergiant, we present two-dimensional hydrodynamical simulations using the PROMETHEUS code to demonstrate how the penetration depth and post-impact conditions depend on the initial properties of the stream material (e.g. entropy, angular momentum, stream width) and the properties of the core (e.g. density structure and rotation rate). Using these results, we present a fitting formula for the entropy generated in the stream-core interaction and a recipe for the determination of the penetration depth based on a modified Bernoulli integral.

Neutronics calculation of RTP core

NASA Astrophysics Data System (ADS)

Rabir, Mohamad Hairie B.; Zin, Muhammad Rawi B. Mohamed; Karim, Julia Bt. Abdul; Bayar, Abi Muttaqin B. Jalal; Usang, Mark Dennis Anak; Mustafa, Muhammad Khairul Ariff B.; Hamzah, Na'im Syauqi B.; Said, Norfarizan Bt. Mohd; Jalil, Muhammad Husamuddin B.

2017-01-01

Reactor calculation and simulation are significantly important to ensure safety and better utilization of a research reactor. The Malaysian's PUSPATI TRIGA Reactor (RTP) achieved initial criticality on June 28, 1982. The reactor is designed to effectively implement the various fields of basic nuclear research, manpower training, and production of radioisotopes. Since early 90s, neutronics modelling were used as part of its routine in-core fuel management activities. The are several computer codes have been used in RTP since then, based on 1D neutron diffusion, 2D neutron diffusion and 3D Monte Carlo neutron transport method. This paper describes current progress and overview on neutronics modelling development in RTP. Several important parameters were analysed such as keff, reactivity, neutron flux, power distribution and fission product build-up for the latest core configuration. The developed core neutronics model was validated by means of comparison with experimental and measurement data. Along with the RTP core model, the calculation procedure also developed to establish better prediction capability of RTP's behaviour.

Synonymous Mutations in the Core Gene Are Linked to Unusual Serological Profile in Hepatitis C Virus Infection

PubMed Central

Budkowska, Agata; Kakkanas, Athanassios; Nerrienet, Eric; Kalinina, Olga; Maillard, Patrick; Horm, Srey Viseth; Dalagiorgou, Geena; Vassilaki, Niki; Georgopoulou, Urania; Martinot, Michelle; Sall, Amadou Alpha; Mavromara, Penelope

2011-01-01

The biological role of the protein encoded by the alternative open reading frame (core+1/ARF) of the Hepatitis C virus (HCV) genome remains elusive, as does the significance of the production of corresponding antibodies in HCV infection. We investigated the prevalence of anti-core and anti-core+1/ARFP antibodies in HCV-positive blood donors from Cambodia, using peptide and recombinant protein-based ELISAs. We detected unusual serological profiles in 3 out of 58 HCV positive plasma of genotype 1a. These patients were negative for anti-core antibodies by commercial and peptide-based assays using C-terminal fragments of core but reacted by Western Blot with full-length core protein. All three patients had high levels of anti-core+1/ARFP antibodies. Cloning of the cDNA that corresponds to the core-coding region from these sera resulted in the expression of both core and core+1/ARFP in mammalian cells. The core protein exhibited high amino-acid homology with a consensus HCV1a sequence. However, 10 identical synonymous mutations were found, and 7 were located in the aa(99–124) region of core. All mutations concerned the third base of a codon, and 5/10 represented a T>C mutation. Prediction analyses of the RNA secondary structure revealed conformational changes within the stem-loop region that contains the core+1/ARFP internal AUG initiator at position 85/87. Using the luciferase tagging approach, we showed that core+1/ARFP expression is more efficient from such a sequence than from the prototype HCV1a RNA. We provide additional evidence of the existence of core+1/ARFP in vivo and new data concerning expression of HCV core protein. We show that HCV patients who do not produce normal anti-core antibodies have unusually high levels of antit-core+1/ARFP and harbour several identical synonymous mutations in the core and core+1/ARFP coding region that result in major changes in predicted RNA structure. Such HCV variants may favour core+1/ARFP production during HCV infection. PMID:21283512

Delayed Geodynamo in Hadean

NASA Astrophysics Data System (ADS)

Arkani-Hamed, J.

2014-12-01

Paleointensity measurements of Archean rocks reveal a strong geodynamo at ~3.45 Ga, while excess nitrogen content of lunar soil samples implies no geodynamo at ~3.9 Ga. Here I propose that initiation of a strong geodynamo is delayed due to accretion style of Earth, involving collision and merging of a few dozen Moon to Mars size planetary embryos. Two accretion scenarios consisting of 25 and 50 embryos are investigated. The collision of an embryo heats the proto-Earth's core differentially and the rotating low-viscosity core stably stratifies, creating a spherically symmetric and radially increasing temperature distribution. Convection starts in the outer core after each impact but is destroyed by the next impact. The iron core of an impacting embryo descends in the mantle and merges to the proto-Earth's core. Both adiabatic and non-adiabatic merging cases are studied. A major part of the gravitational energy released due to core merging is used to lift up the upper portion of the core to emplace the impactor core material at the neutrally buoyant level in the proto-Earth's core. The remaining energy is converted to heat. In the adiabatic case the merging embryo's core retains all of the remaining energy, while in the non-adiabatic merging 50% of the remaining energy is shared with the outer part of the proto-Earth's core where the embryo's core descends. The two merging models result in significantly different temperature distributions in the core at the end of accretion. After the accretion, the convecting shell in the outer core grows monotonically and generates geodynamo gradually. It takes about 50-100 Myr for the convecting shell to generate a strong dipole field at the surface, 50,000 to 100,000 nT, in the presence of a large stably stratified liquid inner core when the convecting outer core thickness exceeds about one half the radius of the Earth's core.

Paleomagnetic results from IODP Expedition 344 Site U1381 and implications for the initial subduction of the Cocos Ridge

NASA Astrophysics Data System (ADS)

Li, Yong-Xiang; Zhao, Xixi; Jovane, Luigi; Petronotis, Katerina; Gong, Zheng; Xie, Siyi

2016-04-01

Understanding the processes that govern the strength, nature, and distribution of slip along subduction zones is a fundamental and societally relevant goal of modern earth science. The Costa Rica Seismogenesis Project (CRISP) is specially designed to understand the processes that control nucleation and seismic rupture of large earthquakes at erosional subduction zones. Drilling directly on the Cocos Ridge (CR) during International Ocean Drilling Program (IODP) Expedition 344 discovered a sedimentary hiatus in Site U1381 cores. In this study, we conducted a magnetostratigraphic and rock magnetic study on the Cenozoic sedimentary sequences of site U1381. Anisotropy of magnetic susceptibility data from sediments above and below the hiatus show oblate fabrcis, but the Kmin axes of the AMS data from sediments below the hiatus are more dispersed than those from sediments above the hiatus, implying that formation of hiatus may have affected AMS. Paleomagnetic results of the U1381 core, together with available Ar-Ar dates of ash layers from sediments below the hiatus, allow us to establish a geomagnetic polarity timescale that brackets the hiatus between ca. 9.61 and 1.52 Ma. Analyses of sedimentary records from ODP/IODP cores in the vicinity reveal that the hiatus appears to be regional, spanning the northeastern end of the CR. Also, the hiatus appears to occur only at certain locations. Its regional occurrence at unique locations implies a link to the initial shallow subduction of the Cocos Ridge. The hiatus was probably produced by either bottom current erosion or the CR buckling upon its initial collision with the Middle American trench (MAT). Thus, the initial subduction of the CR must have taken place on or before 1.52 Ma.

Experimental Study of the Richtmyer-Meshkov Instability of Incompressible Fluids

NASA Technical Reports Server (NTRS)

Niederhaus, Charles; Jacobs, Jeffrey W.

2002-01-01

The Richtmyer-Meshkov instability of a low Atwood number, miscible, two-liquid system is investigated experimentally. The initially stratified fluids are contained within a rectangular tank mounted to a sled that rides on a vertical set of rails. The instability is generated by dropping the sled onto a coil spring, producing a nearly impulsive upward acceleration. The subsequent freefall that occurs as the container travels upward and then downward on the rails allows the instability to evolve in the absence of gravity. The interface separating the two liquids initially has a well-defined, sinusoidal perturbation that quickly inverts and then grows in amplitude after undergoing the impulsive acceleration. Disturbance amplitudes are measured and compared to theoretical predictions. Linear stability theory gives excellent agreement with the measured initial growth rate, a(sub 0), for single-mode perturbations with the predicted amplitudes differing by less than 10% from experimental measurements up to a nondimensional time ka(sub 0)t = 0.7, where k is the wavenumber. Linear stability theory also provides excellent agreement for the individual mode amplitudes of multi-mode initial perturbations up until the interface becomes multi-valued. Comparison with previously published weakly nonlinear single-mode models shows good agreement up to ka(sub 0)t = 3, while published nonlinear single-mode models provide good agreement up to ka(sub 0)t = 30. The effects of Reynolds number on the vortex core evolution and overall growth rate of the interface are also investigated. Measurements of the overall amplitude are found to be unaffected by the Reynolds number for the range of values studied here. However, experiments carried out at lower values of Reynolds numbers were found to have decreased vortex core rotation rates. In addition, an instability in the vortex cores is observed.

Direct Heating of a Laser-Imploded Core by Ultraintense Laser-Driven Ions

NASA Astrophysics Data System (ADS)

Kitagawa, Y.; Mori, Y.; Komeda, O.; Ishii, K.; Hanayama, R.; Fujita, K.; Okihara, S.; Sekine, T.; Satoh, N.; Kurita, T.; Takagi, M.; Watari, T.; Kawashima, T.; Kan, H.; Nishimura, Y.; Sunahara, A.; Sentoku, Y.; Nakamura, N.; Kondo, T.; Fujine, M.; Azuma, H.; Motohiro, T.; Hioki, T.; Kakeno, M.; Miura, E.; Arikawa, Y.; Nagai, T.; Abe, Y.; Ozaki, S.; Noda, A.

2015-05-01

A novel direct core heating fusion process is introduced, in which a preimploded core is predominantly heated by energetic ions driven by LFEX, an extremely energetic ultrashort pulse laser. Consequently, we have observed the D (d ,n )He 3 -reacted neutrons (DD beam-fusion neutrons) with the yield of 5 ×108 n /4 π sr . Examination of the beam-fusion neutrons verified that the ions directly collide with the core plasma. While the hot electrons heat the whole core volume, the energetic ions deposit their energies locally in the core, forming hot spots for fuel ignition. As evidenced in the spectrum, the process simultaneously excited thermal neutrons with the yield of 6 ×107 n /4 π sr , raising the local core temperature from 0.8 to 1.8 keV. A one-dimensional hydrocode STAR 1D explains the shell implosion dynamics including the beam fusion and thermal fusion initiated by fast deuterons and carbon ions. A two-dimensional collisional particle-in-cell code predicts the core heating due to resistive processes driven by hot electrons, and also the generation of fast ions, which could be an additional heating source when they reach the core. Since the core density is limited to 2 g /cm3 in the current experiment, neither hot electrons nor fast ions can efficiently deposit their energy and the neutron yield remains low. In future work, we will achieve the higher core density (>10 g /cm3 ); then hot electrons could contribute more to the core heating via drag heating. Together with hot electrons, the ion contribution to fast ignition is indispensable for realizing high-gain fusion. By virtue of its core heating and ignition, the proposed scheme can potentially achieve high gain fusion.

Direct heating of a laser-imploded core by ultraintense laser-driven ions.

PubMed

Kitagawa, Y; Mori, Y; Komeda, O; Ishii, K; Hanayama, R; Fujita, K; Okihara, S; Sekine, T; Satoh, N; Kurita, T; Takagi, M; Watari, T; Kawashima, T; Kan, H; Nishimura, Y; Sunahara, A; Sentoku, Y; Nakamura, N; Kondo, T; Fujine, M; Azuma, H; Motohiro, T; Hioki, T; Kakeno, M; Miura, E; Arikawa, Y; Nagai, T; Abe, Y; Ozaki, S; Noda, A

2015-05-15

A novel direct core heating fusion process is introduced, in which a preimploded core is predominantly heated by energetic ions driven by LFEX, an extremely energetic ultrashort pulse laser. Consequently, we have observed the D(d,n)^{3}He-reacted neutrons (DD beam-fusion neutrons) with the yield of 5×10^{8} n/4π sr. Examination of the beam-fusion neutrons verified that the ions directly collide with the core plasma. While the hot electrons heat the whole core volume, the energetic ions deposit their energies locally in the core, forming hot spots for fuel ignition. As evidenced in the spectrum, the process simultaneously excited thermal neutrons with the yield of 6×10^{7} n/4π sr, raising the local core temperature from 0.8 to 1.8 keV. A one-dimensional hydrocode STAR 1D explains the shell implosion dynamics including the beam fusion and thermal fusion initiated by fast deuterons and carbon ions. A two-dimensional collisional particle-in-cell code predicts the core heating due to resistive processes driven by hot electrons, and also the generation of fast ions, which could be an additional heating source when they reach the core. Since the core density is limited to 2 g/cm^{3} in the current experiment, neither hot electrons nor fast ions can efficiently deposit their energy and the neutron yield remains low. In future work, we will achieve the higher core density (>10 g/cm^{3}); then hot electrons could contribute more to the core heating via drag heating. Together with hot electrons, the ion contribution to fast ignition is indispensable for realizing high-gain fusion. By virtue of its core heating and ignition, the proposed scheme can potentially achieve high gain fusion.

Core principles of evolutionary medicine

PubMed Central

Grunspan, Daniel Z; Nesse, Randolph M; Barnes, M Elizabeth; Brownell, Sara E

2018-01-01

Abstract Background and objectives Evolutionary medicine is a rapidly growing field that uses the principles of evolutionary biology to better understand, prevent and treat disease, and that uses studies of disease to advance basic knowledge in evolutionary biology. Over-arching principles of evolutionary medicine have been described in publications, but our study is the first to systematically elicit core principles from a diverse panel of experts in evolutionary medicine. These principles should be useful to advance recent recommendations made by The Association of American Medical Colleges and the Howard Hughes Medical Institute to make evolutionary thinking a core competency for pre-medical education. Methodology The Delphi method was used to elicit and validate a list of core principles for evolutionary medicine. The study included four surveys administered in sequence to 56 expert panelists. The initial open-ended survey created a list of possible core principles; the three subsequent surveys winnowed the list and assessed the accuracy and importance of each principle. Results Fourteen core principles elicited at least 80% of the panelists to agree or strongly agree that they were important core principles for evolutionary medicine. These principles over-lapped with concepts discussed in other articles discussing key concepts in evolutionary medicine. Conclusions and implications This set of core principles will be helpful for researchers and instructors in evolutionary medicine. We recommend that evolutionary medicine instructors use the list of core principles to construct learning goals. Evolutionary medicine is a young field, so this list of core principles will likely change as the field develops further. PMID:29493660

Core principles of evolutionary medicine: A Delphi study.

PubMed

Grunspan, Daniel Z; Nesse, Randolph M; Barnes, M Elizabeth; Brownell, Sara E

2018-01-01

Evolutionary medicine is a rapidly growing field that uses the principles of evolutionary biology to better understand, prevent and treat disease, and that uses studies of disease to advance basic knowledge in evolutionary biology. Over-arching principles of evolutionary medicine have been described in publications, but our study is the first to systematically elicit core principles from a diverse panel of experts in evolutionary medicine. These principles should be useful to advance recent recommendations made by The Association of American Medical Colleges and the Howard Hughes Medical Institute to make evolutionary thinking a core competency for pre-medical education. The Delphi method was used to elicit and validate a list of core principles for evolutionary medicine. The study included four surveys administered in sequence to 56 expert panelists. The initial open-ended survey created a list of possible core principles; the three subsequent surveys winnowed the list and assessed the accuracy and importance of each principle. Fourteen core principles elicited at least 80% of the panelists to agree or strongly agree that they were important core principles for evolutionary medicine. These principles over-lapped with concepts discussed in other articles discussing key concepts in evolutionary medicine. This set of core principles will be helpful for researchers and instructors in evolutionary medicine. We recommend that evolutionary medicine instructors use the list of core principles to construct learning goals. Evolutionary medicine is a young field, so this list of core principles will likely change as the field develops further.

Sediment mineralogy based on visible and near-infrared reflectance spectroscopy

USGS Publications Warehouse

Jarrard, R.D.; Vanden Berg, M.D.; ,

2006-01-01

Visible and near-infrared spectroscopy (VNIS) can be used to measure reflectance spectra (wavelength 350-2500 nm) for sediment cores and samples. A local ground-truth calibration of spectral features to mineral percentages is calculated by measuring reflectance spectra for a suite of samples of known mineralogy. This approach has been tested on powders, core plugs and split cores, and we conclude that it works well on all three, unless pore water is present. Initial VNIS studies have concentrated on determination of relative proportions of carbonate, opal, smectite and illite in equatorial Pacific sediments. Shipboard VNIS-based determination of these four components was demonstrated on Ocean Drilling Program Leg 199. ?? The Geological Society of London 2006.

Coannular supersonic ejector nozzles

NASA Technical Reports Server (NTRS)

Bishop, A. R.

1979-01-01

The nozzles described exhibit a flow field which is supersonic except for the initial flow region, and the secondary mass flow is typically about five percent of the primary core flow. The features to improve the accuracy of the performance calculations are discussed. A special calculation is made to get as realistic a sonic line as possible for this geometry, using an analysis developed by Brown. The mixing between the secondary and core flows is treated to account for entrainment of the secondary flow into core. Both of these phenomena directly affect the pressure distribution on the shroud and therefore, the thrust that the nozzle produces. The importance of using a realistic sonic line and a mixing analysis is stressed.

The 3D Death of a Massive Star

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2015-07-01

What happens at the very end of a massive star's life, just before its core's collapse? A group led by Sean Couch (California Institute of Technology and Michigan State University) claim to have carried out the first three-dimensional simulations of these final few minutes — revealing new clues about the factors that can lead a massive star to explode in a catastrophic supernova at the end of its life. A Giant Collapses In dying massive stars, in-falling matter bounces off the of collapsed core, creating a shock wave. If the shock wave loses too much energy as it expands into the star, it can stall out — but further energy input can revive it and result in a successful explosion of the star as a core-collapse supernova. In simulations of this process, however, theorists have trouble getting the stars to consistently explode: the shocks often stall out and fail to revive. Couch and his group suggest that one reason might be that these simulations usually start at core collapse assuming spherical symmetry of the progenitor star. Adding Turbulence Couch and his collaborators suspect that the key is in the final minutes just before the star collapses. Models that assume a spherically-symmetric star can't include the effects of convection as the final shell of silicon is burned around the core — and those effects might have a significant impact! To test this hypothesis, the group ran fully 3D simulations of the final three minutes of the life of a 15 solar-mass star, ending with core collapse, bounce, and shock-revival. The outcome was striking: the 3D modeling introduced powerful turbulent convection (with speeds of several hundred km/s!) in the last few minutes of silicon-shell burning. As a result, the initial structure and motions in the star just before core collapse were very different from those in core-collapse simulations that use spherically-symmetric initial conditions. The turbulence was then further amplified during collapse and formation of the shock, generating pressure that aided the shock expansion — which should ultimately help the star explode! The group cautions that their simulations are still very idealized, but these results clearly indicate that the 3D structure of massive stellar cores has an important impact on the core-collapse supernova mechanism. Citation Sean M. Couch et al. 2015 ApJ 808 L21 doi:10.1088/2041-8205/808/1/L21

What Should We Grow in Our School Garden to Sell at the Farmers' Market? Initiating Statistical Literacy through Science and Mathematics Integration

ERIC Educational Resources Information Center

Selmer, Sarah J.; Rye, James A.; Malone, Elizabeth; Fernandez, Danielle; Trebino, Kathryn

2014-01-01

Statistical literacy is essential to scientific literacy, and the quest for such is best initiated in the elementary grades. The "Next Generation Science Standards and the Common Core State Standards for Mathematics" set forth practices (e.g., asking questions, using tools strategically to analyze and interpret data) and content (e.g.,…

Issues in NASA Program and Project Management. Special Report: 1997 Conference. Project Management Now and in the New Millennium

NASA Technical Reports Server (NTRS)

Hoffman, Edward J. (Editor); Lawbaugh, William M. (Editor)

1997-01-01

Topics Considered Include: NASA's Shared Experiences Program; Core Issues for the Future of the Agency; National Space Policy Strategic Management; ISO 9000 and NASA; New Acquisition Initiatives; Full Cost Initiative; PM Career Development; PM Project Database; NASA Fast Track Studies; Fast Track Projects; Earned Value Concept; Value-Added Metrics; Saturn Corporation Lessons Learned; Project Manager Credibility.

The climate adaptation programs and activities of the Yellowstone to Yukon Conservation Initiative

Treesearch

Wendy L. Francis

2011-01-01

The Yellowstone to Yukon Conservation Initiative (Y2Y) is an innovative transboundary effort to protect biodiversity and facilitate climate adaptation by linking large protected core areas through compatible land uses on matrix lands. The Y2Y organization acts as the keeper of the Y2Y vision and implements two interconnected programs - Science and Action, and Vision...

CCC7-119 Reactive Molecular Dynamics Simulations of Hot Spot Growth in Shocked Energetic Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, Aidan P.

2015-03-01

The purpose of this work is to understand how defects control initiation in energetic materials used in stockpile components; Sequoia gives us the core-count to run very large-scale simulations of up to 10 million atoms and; Using an OpenMP threaded implementation of the ReaxFF package in LAMMPS, we have been able to get good parallel efficiency running on 16k nodes of Sequoia, with 1 hardware thread per core.

Image analysis of the AXAF VETA-I x ray mirror

NASA Technical Reports Server (NTRS)

Freeman, Mark D.; Hughes, John P; Vanspeybroeck, L.; Weisskopf, M.; Bilbro, J.

1992-01-01

Initial core scan data of the VETA-I x-ray mirror proved disappointing, showing considerable unpredicted image structure and poor measured FWHM. 2-D core scans were performed, providing important insight into the nature of the distortion. Image deconvolutions using a ray traced model PSF was performed successfully to reinforce our conclusion regarding the origin of the astigmatism. A mechanical correction was made to the optical structure, and the mirror was tested successfully (FWHM 0.22 arcsec) as a result.

Engineering and Physics Optimization of Breed and Burn Fast Reactor Systems; NUCLEAR ENERGY RESEARCH INITIATIVE (NERI) QUARTERLY PROGRESS REPORT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pavel Hejzlar, Peter Yarsky, Mike Driscoll, Dan Wachs, Kevan Weaver, Ken Czerwinski, Mike Pope, James Parry, Theron D. Marshall, Cliff B. Davis, Dustin Crawford, Thomas Hartmann, Pradip Saha; Hejzlar, Pavel; Yarsky, Peter

2005-01-31

This project is organized under four major tasks (each of which has two or more subtasks) with contributions among the three collaborating organizations (MIT, INEEL and ANL-West): Task A: Core Physics and Fuel Cycle; Task B: Core Thermal Hydraulics; Task C: Plant Design; Task D: Fuel Design The lead PI, Michael J. Driscoll, has consolidated and summarized the technical progress submissions provided by the contributing investigators from all sites, under the above principal task headings.

Topics in Optical Materials and Device Research - II. Volume II.

DTIC Science & Technology

1982-01-01

FILE AND STORE IT IN CORE ACCA /IF NO FILE, ASSUME IT IS ALREADY IN CORE (NIC) JMS @ZERTAB /ZERO THE COMMAND TABLE TABLA /INITIALIZE THE CAMERA TABLE TO...BEFORE CALLING. WILL FIND THE FIRST AVAILABLE SPACE. *2420 OPENW, 0 JMS DIRFIN MONM @DISOLV JMS 0DIRFUN 1 2 NOFIL /POINTS TO A VALUE OF 0 ACCA JMS...ACCM FILNM MPOM CLOSE MEMA @CLOSE ACCM FILNM+I MPOM CLOSE JMS DIRFIN JMS @DIRFUN 1 1 FILNM ACCA JMS DIROUT JMP @CLOSE / // SUBROUTINE WRITE(IT,SIZE

A High-Mass Cold Core in the Auriga-California Giant Molecular Cloud

NASA Astrophysics Data System (ADS)

Magnus McGehee, Peregrine; Paladini, Roberta; Pelkonen, Veli-Matti; Toth, Viktor; Sayers, Jack

2015-08-01

The Auriga-California Giant Molecular Cloud is noted for its relatively low star formation rate, especially at the high-mass end of the Initial Mass Function. We combine maps acquired by the Caltech Submillimeter Observatory's Multiwavelength Submillimeter Inductance Camera [MUSIC] in the wavelength range 0.86 to 2.00 millimeters with Planck and publicly-available Herschel PACS and SPIRE data in order to characterize the mass, dust properties, and environment of the bright core PGCC G163.32-8.41.

Managing the clinical setting for best nursing practice: a brief overview of contemporary initiatives.

PubMed

Henderson, Amanda; Winch, Sarah

2008-01-01

Leadership strategies are important in facilitating the nursing profession to reach their optimum standards in the practice environment. To compare and contrast the central tenets of contemporary quality initiatives that are commensurate with enabling the environment so that best practice can occur. Democratic leadership, accessible and relevant education and professional development, the incorporation of evidence into practice and the ability of facilities to be responsive to change are core considerations for the successful maintenance of practice standards that are consistent with best nursing practice. While different concerns of management drive the adoption of contemporary approaches, there are many similarities in the how these approaches are translated into action in the clinical setting. Managers should focus on core principles of professional nursing that add value to practice rather than business processes.

Convection- and SASI-driven flows in parametrized models of core-collapse supernova explosions

DOE PAGES

Endeve, E.; Cardall, C. Y.; Budiardja, R. D.; ...

2016-01-21

We present initial results from three-dimensional simulations of parametrized core-collapse supernova (CCSN) explosions obtained with our astrophysical simulation code General Astrophysical Simulation System (GenASIS). We are interested in nonlinear flows resulting from neutrino-driven convection and the standing accretion shock instability (SASI) in the CCSN environment prior to and during the explosion. By varying parameters in our model that control neutrino heating and shock dissociation, our simulations result in convection-dominated and SASI-dominated evolution. We describe this initial set of simulation results in some detail. To characterize the turbulent flows in the simulations, we compute and compare velocity power spectra from convection-dominatedmore » and SASI-dominated (both non-exploding and exploding) models. When compared to SASI-dominated models, convection-dominated models exhibit significantly more power on small spatial scales.« less

Evaluation of potential severe accidents during low power and shutdown operations at Surry, Unit 1: Analysis of core damage frequency from internal events during mid-loop operations, Appendices E (Sections E.1--E.8). Volume 2, Part 3A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chu, T.L.; Musicki, Z.; Kohut, P.

1994-06-01

During 1989, the Nuclear Regulatory Commission (NRC) initiated an extensive program to carefully examine the potential risks during low power and shutdown operations. The program includes two parallel projects being performed by Brookhaven National Laboratory (BNL) and Sandia National Laboratories (SNL). Two plants, Surry (pressurized water reactor) and Grand Gulf (boiling water reactor), were selected as the plants to be studied. The objectives of the program are to assess the risks of severe accidents initiated during plant operational states other than full power operation and to compare the estimated core damage frequencies, important accident sequences and other qualitative and quantitativemore » results with those accidents initiated during full power operation as assessed in NUREG-1150. The objective of this report is to document the approach utilized in the Surry plant and discuss the results obtained. A parallel report for the Grand Gulf plant is prepared by SNL. This study shows that the core-damage frequency during mid-loop operation at the Surry plant is comparable to that of power operation. The authors recognize that there is very large uncertainty in the human error probabilities in this study. This study identified that only a few procedures are available for mitigating accidents that may occur during shutdown. Procedures written specifically for shutdown accidents would be useful.« less

Design of epoxy-functionalized Fe3O4@MCM-41 core-shell nanoparticles for enzyme immobilization.

PubMed

Ulu, Ahmet; Ozcan, Imren; Koytepe, Suleyman; Ates, Burhan

2018-05-01

The scope of our research was to prepare the organosilane-modified Fe 3 O 4 @MCM-41 core-shell magnetic nanoparticles, used for L-ASNase immobilization and explored screening of immobilization conditions such as pH, temperature, thermal stability, kinetic parameters, reusability and storage stability. In this content, Fe 3 O 4 core-shell magnetic nanoparticles were prepared via co-precipitation method and coated with MCM-41. Then, Fe 3 O 4 @MCM-41 magnetic nanoparticles were functionalized by (3-glycidyloxypropyl) trimethoxysilane (GPTMS) as an organosilane compound. Subsequently, L-ASNase was covalently immobilized on epoxy-functionalized Fe 3 O 4 @MCM-41 magnetic nanoparticles. The immobilized L-ASNase had greater activity at high pH and temperature values. It also maintained >92% of the initial activity after incubation at 55 °C for 3 h. Regarding kinetic values, immobilized L-ASNase showed a higher Vmax and lower Km compared to native L-ASNase. In addition, it displayed excellent reusability for 12 successive cycles. After 30 days of storage at 4 °C and 25 °C, immobilized L-ASNase retained 54% and 26% of its initial activities while native L-ASNase lost about 68% and 84% of its initial activity, respectively. As a result, the immobilization of L-ASNase onto magnetic nanoparticles may provide an advantage in terms of removal of L-ASNase from reaction media. Copyright © 2018. Published by Elsevier B.V.

Experiments and modeling of variably permeable carbonate reservoir samples in contact with CO₂-acidified brines

DOE PAGES

Smith, Megan M.; Hao, Yue; Mason, Harris E.; ...

2014-12-31

Reactive experiments were performed to expose sample cores from the Arbuckle carbonate reservoir to CO₂-acidified brine under reservoir temperature and pressure conditions. The samples consisted of dolomite with varying quantities of calcite and silica/chert. The timescales of monitored pressure decline across each sample in response to CO₂ exposure, as well as the amount of and nature of dissolution features, varied widely among these three experiments. For all samples cores, the experimentally measured initial permeability was at least one order of magnitude or more lower than the values estimated from downhole methods. Nondestructive X-ray computed tomography (XRCT) imaging revealed dissolution featuresmore » including “wormholes,” removal of fracture-filling crystals, and widening of pre-existing pore spaces. In the injection zone sample, multiple fractures may have contributed to the high initial permeability of this core and restricted the distribution of CO₂-induced mineral dissolution. In contrast, the pre-existing porosity of the baffle zone sample was much lower and less connected, leading to a lower initial permeability and contributing to the development of a single dissolution channel. While calcite may make up only a small percentage of the overall sample composition, its location and the effects of its dissolution have an outsized effect on permeability responses to CO₂ exposure. The XRCT data presented here are informative for building the model domain for numerical simulations of these experiments but require calibration by higher resolution means to confidently evaluate different porosity-permeability relationships.« less

Advanced Test Reactor Core Modeling Update Project Annual Report for Fiscal Year 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

David W. Nigg, Principal Investigator; Kevin A. Steuhm, Project Manager

Legacy computational reactor physics software tools and protocols currently used for support of Advanced Test Reactor (ATR) core fuel management and safety assurance, and to some extent, experiment management, are inconsistent with the state of modern nuclear engineering practice, and are difficult, if not impossible, to properly verify and validate (V&V) according to modern standards. Furthermore, the legacy staff knowledge required for application of these tools and protocols from the 1960s and 1970s is rapidly being lost due to staff turnover and retirements. In late 2009, the Idaho National Laboratory (INL) initiated a focused effort, the ATR Core Modeling Updatemore » Project, to address this situation through the introduction of modern high-fidelity computational software and protocols. This aggressive computational and experimental campaign will have a broad strategic impact on the operation of the ATR, both in terms of improved computational efficiency and accuracy for support of ongoing DOE programs as well as in terms of national and international recognition of the ATR National Scientific User Facility (NSUF). The ATR Core Modeling Update Project, targeted for full implementation in phase with the next anticipated ATR Core Internals Changeout (CIC) in the 2014-2015 time frame, began during the last quarter of Fiscal Year 2009, and has just completed its third full year. Key accomplishments so far have encompassed both computational as well as experimental work. A new suite of stochastic and deterministic transport theory based reactor physics codes and their supporting nuclear data libraries (HELIOS, KENO6/SCALE, NEWT/SCALE, ATTILA, and an extended implementation of MCNP5) has been installed at the INL under various licensing arrangements. Corresponding models of the ATR and ATRC are now operational with all five codes, demonstrating the basic feasibility of the new code packages for their intended purpose. Of particular importance, a set of as-run core depletion HELIOS calculations for all ATR cycles since August 2009, Cycle 145A through Cycle 151B, was successfully completed during 2012. This major effort supported a decision late in the year to proceed with the phased incorporation of the HELIOS methodology into the ATR Core Safety Analysis Package (CSAP) preparation process, in parallel with the established PDQ-based methodology, beginning late in Fiscal Year 2012. Acquisition of the advanced SERPENT (VTT-Finland) and MC21 (DOE-NR) Monte Carlo stochastic neutronics simulation codes was also initiated during the year and some initial applications of SERPENT to ATRC experiment analysis were demonstrated. These two new codes will offer significant additional capability, including the possibility of full-3D Monte Carlo fuel management support capabilities for the ATR at some point in the future. Finally, a capability for rigorous sensitivity analysis and uncertainty quantification based on the TSUNAMI system has been implemented and initial computational results have been obtained. This capability will have many applications as a tool for understanding the margins of uncertainty in the new models as well as for validation experiment design and interpretation.« less

Sensitivities of Earth's core and mantle compositions to accretion and differentiation processes

NASA Astrophysics Data System (ADS)

Fischer, Rebecca A.; Campbell, Andrew J.; Ciesla, Fred J.

2017-01-01

The Earth and other terrestrial planets formed through the accretion of smaller bodies, with their core and mantle compositions primarily set by metal-silicate interactions during accretion. The conditions of these interactions are poorly understood, but could provide insight into the mechanisms of planetary core formation and the composition of Earth's core. Here we present modeling of Earth's core formation, combining results of 100 N-body accretion simulations with high pressure-temperature metal-silicate partitioning experiments. We explored how various aspects of accretion and core formation influence the resulting core and mantle chemistry: depth of equilibration, amounts of metal and silicate that equilibrate, initial distribution of oxidation states in the disk, temperature distribution in the planet, and target:impactor ratio of equilibrating silicate. Virtually all sets of model parameters that are able to reproduce the Earth's mantle composition result in at least several weight percent of both silicon and oxygen in the core, with more silicon than oxygen. This implies that the core's light element budget may be dominated by these elements, and is consistent with ≤1-2 wt% of other light elements. Reproducing geochemical and geophysical constraints requires that Earth formed from reduced materials that equilibrated at temperatures near or slightly above the mantle liquidus during accretion. The results indicate a strong tradeoff between the compositional effects of the depth of equilibration and the amounts of metal and silicate that equilibrate, so these aspects should be targeted in future studies aiming to better understand core formation conditions. Over the range of allowed parameter space, core and mantle compositions are most sensitive to these factors as well as stochastic variations in what the planet accreted as a function of time, so tighter constraints on these parameters will lead to an improved understanding of Earth's core composition.

Non-Destructive Current Sensing for Energy Efficiency Monitoring in Buildings with Environmental Certification

PubMed Central

Mota, Lia Toledo Moreira; Mota, Alexandre de Assis; Coiado, Lorenzo Campos

2015-01-01

Nowadays, buildings environmental certifications encourage the implementation of initiatives aiming to increase energy efficiency in buildings. In these certification systems, increased energy efficiency arising from such initiatives must be demonstrated. Thus, a challenge to be faced is how to check the increase in energy efficiency related to each of the employed initiatives without a considerable building retrofit. In this context, this work presents a non-destructive method for electric current sensing to assess implemented initiatives to increase energy efficiency in buildings with environmental certification. This method proposes the use of a sensor that can be installed directly in the low voltage electrical circuit conductors that are powering the initiative under evaluation, without the need for reforms that result in significant costs, repair, and maintenance. The proposed sensor consists of three elements: an air-core transformer current sensor, an amplifying/filtering stage, and a microprocessor. A prototype of the proposed sensor was developed and tests were performed to validate this sensor. Based on laboratory tests, it was possible to characterize the proposed current sensor with respect to the number of turns and cross-sectional area of the primary and secondary coils. Furthermore, using the Least Squares Method, it was possible to determine the efficiency of the air core transformer current sensor (the best efficiency found, considering different test conditions, was 2%), which leads to a linear output response. PMID:26184208

Non-Destructive Current Sensing for Energy Efficiency Monitoring in Buildings with Environmental Certification.

PubMed

Mota, Lia Toledo Moreira; Mota, Alexandre de Assis; Coiado, Lorenzo Campos

2015-07-10

Nowadays, buildings environmental certifications encourage the implementation of initiatives aiming to increase energy efficiency in buildings. In these certification systems, increased energy efficiency arising from such initiatives must be demonstrated. Thus, a challenge to be faced is how to check the increase in energy efficiency related to each of the employed initiatives without a considerable building retrofit. In this context, this work presents a non-destructive method for electric current sensing to assess implemented initiatives to increase energy efficiency in buildings with environmental certification. This method proposes the use of a sensor that can be installed directly in the low voltage electrical circuit conductors that are powering the initiative under evaluation, without the need for reforms that result in significant costs, repair, and maintenance. The proposed sensor consists of three elements: an air-core transformer current sensor, an amplifying/filtering stage, and a microprocessor. A prototype of the proposed sensor was developed and tests were performed to validate this sensor. Based on laboratory tests, it was possible to characterize the proposed current sensor with respect to the number of turns and cross-sectional area of the primary and secondary coils. Furthermore, using the Least Squares Method, it was possible to determine the efficiency of the air core transformer current sensor (the best efficiency found, considering different test conditions, was 2%), which leads to a linear output response.

The Synthesis and Characterization of Gold-Core/LDH-Shell Nanoparticles

NASA Astrophysics Data System (ADS)

Rearick, Colton

In recent years, the field of nanomedicine has progressed at an astonishing rate, particularly with respect to applications in cancer treatment and molecular imaging. Although organic systems have been the frontrunners, inorganic systems have also begun to show promise, especially those based upon silica and magnetic nanoparticles (NPs). Many of these systems are being designed for simultaneous therapeutic and diagnostic capabilities, thus coining the term, theranostics. A unique class of inorganic systems that shows great promise as theranostics is that of layered double hydroxides (LDH). By synthesis of a core/shell structures, e.g. a gold nanoparticle (NP) core and LDH shell, the multifunctional theranostic may be developed without a drastic increase in the structural complexity. To demonstrate initial proof-of-concept of a potential (inorganic) theranostic platform, a Au-core/LDH-shell nanovector has been synthesized and characterized. The LDH shell was heterogeneously nucleated and grown on the surface of silica coated gold NPs via a coprecipitation method. Polyethylene glycol (PEG) was introduced in the initial synthesis steps to improve crystallinity and colloidal stability. Additionally, during synthesis, fluorescein isothiocyanate (FITC) was intercalated into the interlayer spacing of the LDH. In contrast to the PEG stabilization, a post synthesis citric acid treatment was used as a method to control the size and short-term stability. The heterogeneous core-shell system was characterized with scanning electron microscopy (SEM), energy dispersive x-ray spectroscopy (EDX), dynamic light scattering (DLS), and powder x-ray diffraction (PXRD). A preliminary in vitro study carried out with the assistance of Dr. Kaushal Rege's group at Arizona State University was to demonstrate the endocytosis capability of homogeneously-grown LDH NPs. The DLS measurements of the core-shell NPs indicated an average particle size of 212nm. The PXRD analysis showed that PEG greatly improved the crystallinity of the system while simultaneously preventing aggregation of the NPs. The preliminary in vitro fluorescence microscopy revealed a moderate uptake of homogeneous LDH NPs into the cells.

Plastic damage induced fracture behaviors of dental ceramic layer structures subjected to monotonic load.

PubMed

Wang, Raorao; Lu, Chenglin; Arola, Dwayne; Zhang, Dongsheng

2013-08-01

The aim of this study was to compare failure modes and fracture strength of ceramic structures using a combination of experimental and numerical methods. Twelve specimens with flat layer structures were fabricated from two types of ceramic systems (IPS e.max ceram/e.max press-CP and Vita VM9/Lava zirconia-VZ) and subjected to monotonic load to fracture with a tungsten carbide sphere. Digital image correlation (DIC) and fractography technology were used to analyze fracture behaviors of specimens. Numerical simulation was also applied to analyze the stress distribution in these two types of dental ceramics. Quasi-plastic damage occurred beneath the indenter in porcelain in all cases. In general, the fracture strength of VZ specimens was greater than that of CP specimens. The crack initiation loads of VZ and CP were determined as 958 ± 50 N and 724 ± 36 N, respectively. Cracks were induced by plastic damage and were subsequently driven by tensile stress at the elastic/plastic boundary and extended downward toward to the veneer/core interface from the observation of DIC at the specimen surface. Cracks penetrated into e.max press core, which led to a serious bulk fracture in CP crowns, while in VZ specimens, cracks were deflected and extended along the porcelain/zirconia core interface without penetration into the zirconia core. The rupture loads for VZ and CP ceramics were determined as 1150 ± 170 N and 857 ± 66 N, respectively. Quasi-plastic deformation (damage) is responsible for crack initiation within porcelain in both types of crowns. Due to the intrinsic mechanical properties, the fracture behaviors of these two types of ceramics are different. The zirconia core with high strength and high elastic modulus has better resistance to fracture than the e.max core. © 2013 by the American College of Prosthodontists.

Gas-phase study on uridine: Conformation and X-ray photofragmentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Itälä, Eero, E-mail: ersita@utu.fi; Kooser, Kuno; Levola, Helena

2015-05-21

Fragmentation of RNA nucleoside uridine, induced by carbon 1s core ionization, has been studied. The measurements by combined electron and ion spectroscopy have been performed in gas phase utilizing synchrotron radiation. As uridine is a combination of d-ribose and uracil, which have been studied earlier with the same method, this study also considers the effect of chemical environment and the relevant functional groups. Furthermore, since in core ionization the initial core hole is always highly localized, charge migration prior to fragmentation has been studied here. This study also demonstrates the destructive nature of core ionization as in most cases themore » C 1s ionization of uridine leads to concerted explosions producing only small fragments with masses ≤43 amu. In addition to fragmentation patterns, we found out that upon evaporation the sugar part of the uridine molecule attains hexagonal form.« less

Enhanced flexibility and electron-beam-controlled shape recovery in alumina-coated Au and Ag core-shell nanowires

NASA Astrophysics Data System (ADS)

Vlassov, Sergei; Polyakov, Boris; Vahtrus, Mikk; Mets, Magnus; Antsov, Mikk; Oras, Sven; Tarre, Aivar; Arroval, Tõnis; Lõhmus, Rünno; Aarik, Jaan

2017-12-01

The proper choice of coating materials and methods in core-shell nanowire (NW) engineering is crucial to assuring improved characteristics or even new functionalities of the resulting composite structures. In this paper, we have reported electron-beam-induced reversible elastic-to-plastic transition in Ag/Al2O3 and Au/Al2O3 NWs prepared by the coating of Ag and Au NWs with Al2O3 by low-temperature atomic layer deposition. The observed phenomenon enabled freezing the bent core-shell NW at any arbitrary curvature below the yield strength of the materials and later restoring its initially straight profile by irradiating the NW with electrons. In addition, we demonstrated that the coating efficiently protects the core material from fracture and plastic yield, allowing it to withstand significantly higher deformations and stresses in comparison to uncoated NW.

Strategic bombers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-07-01

This paper reports on the questions: should Congress provide more funds for the Air Force's current plan---the CORE program---to upgrade the B-1B defense avionics system In GAO's view, more testing of the system is not necessary to determine whether to implement the CORE program. Flight testing has shown that the CORE modifications would provide similar operational capabilities to, and offer some survivability improvements over, the existing defense avionics system. The only reason for additional testing would be to prove that some problems with the maintenance diagnostic system has been resolved. Initial testing revealed that while some improvements were achieved, usermore » requirements were not met for such things as low false alarm rates and cannot duplicate rates. Even if the maintenance diagnostic capabilities were fully demonstrated, however, the CORE system should not be implemented until it is known whether the defense avionics system design can support the B-1B's new role as a conventional bomber.« less

Ranking of sabotage/tampering avoidance technology alternatives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andrews, W.B.; Tabatabai, A.S.; Powers, T.B.

1986-01-01

Pacific Northwest Laboratory conducted a study to evaluate alternatives to the design and operation of nuclear power plants, emphasizing a reduction of their vulnerability to sabotage. Estimates of core melt accident frequency during normal operations and from sabotage/tampering events were used to rank the alternatives. Core melt frequency for normal operations was estimated using sensitivity analysis of results of probabilistic risk assessments. Core melt frequency for sabotage/tampering was estimated by developing a model based on probabilistic risk analyses, historic data, engineering judgment, and safeguards analyses of plant locations where core melt events could be initiated. Results indicate the most effectivemore » alternatives focus on large areas of the plant, increase safety system redundancy, and reduce reliance on single locations for mitigation of transients. Less effective options focus on specific areas of the plant, reduce reliance on some plant areas for safe shutdown, and focus on less vulnerable targets.« less

New core-pyrene π structure organophotocatalysts usable as highly efficient photoinitiators

PubMed Central

Telitel, Sofia; Dumur, Frédéric; Faury, Thomas; Graff, Bernadette; Tehfe, Mohamad-Ali; Fouassier, Jean-Pierre

2013-01-01

Summary Eleven di- and trifunctional compounds based on a core-pyrene π structure (Co_Py) were synthesized and investigated for the formation of free radicals. The application of two- and three-component photoinitiating systems (different Co_Pys with the addition of iodonium or sulfonium salts, alkyl halide or amine) was investigated in detail for cationic and radical photopolymerization reactions under near-UV–vis light. The proposed compounds can behave as new photocatalysts. Successful results in terms of rates of polymerization and final conversions were obtained. The strong MO coupling between the six different cores and the pyrene moiety was studied by DFT calculations. The different chemical intermediates are characterized by ESR and laser flash photolysis experiments. The mechanisms involved in the initiation step are discussed, and relationships between the core structure, the Co_Py absorption property, and the polymerization ability are tentatively proposed. PMID:23766803

A vortex-filament and core model for wings with edge vortex separation

NASA Technical Reports Server (NTRS)

Pao, J. L.; Lan, C. E.

1981-01-01

A method for predicting aerodynamic characteristics of slender wings with edge vortex separation was developed. Semiempirical but simple methods were used to determine the initial positions of the free sheet and vortex core. Comparison with available data indicates that: the present method is generally accurate in predicting the lift and induced drag coefficients but the predicted pitching moment is too positive; the spanwise lifting pressure distributions estimated by the one vortex core solution of the present method are significantly better than the results of Mehrotra's method relative to the pressure peak values for the flat delta; the two vortex core system applied to the double delta and strake wing produce overall aerodynamic characteristics which have good agreement with data except for the pitching moment; and the computer time for the present method is about two thirds of that of Mehrotra's method.

The end of the iron-core age.

NASA Technical Reports Server (NTRS)

Lyttleton, R. A.

1973-01-01

The terrestrial planets aggregated essentially from small particles, to begin as solid cool bodies with the same general compositions, and there is no possibility of an iron-core developing within any of them at any stage. Their differing internal and surface properties receive ready explanation from their different masses which determine whether the pressures within are sufficient to bring about phase-changes. The claim that the terrestrial core can be identified by means of shock-wave data as nickel-iron is based on theoretical misconception, whereas the actual seismic data establish an uncompressed-density value much lower than any such mixture could have. The onset of the Ramsey phase-change in the earth takes the form of a rapid initial collapse to produce a large core in metallic state which thereafter continues to grow secularly as a result of radioactive heating and leads to reduction of surface-area at long last adequate to account for folded and thrusted mountain-building.

Individual Differences in Initial Sensitivity and Acute Tolerance Predict Patterns of Chronic Drug Tolerance to Nitrous-Oxide-Induced Hypothermia in Rats

PubMed Central

Ramsay, Douglas S.; Kaiyala, Karl J.; Leroux, Brian G.; Woods, Stephen C.

2006-01-01

Rationale: A preventive strategy for drug addiction would benefit from being able to identify vulnerable individuals. Understanding how an individual responds during an initial drug exposure may be useful for predicting how that individual will respond to repeated drug administrations. Objectives: This study investigated whether individual differences in initial drug sensitivity and acute tolerance can predict how chronic tolerance develops. Methods: During an initial 3-h administration of 60% nitrous oxide (N2O), male Long-Evans rats were screened for N2O’s hypothermic effect into subsets based on being initially insensitive (II), sensitive with acute tolerance (AT), or sensitive with no intrasessional recovery (NR). Animals in each individual difference category were randomly assigned to receive six 90-min exposures of either 60% N2O or placebo gas. Core temperature was measured telemetrically. Results: Rats that exhibited a comparable degree of hypothermia during an initial N2O exposure, but differed in acute tolerance development, developed different patterns of chronic tolerance. Specifically, the NR group did not become fully tolerant over repeated N2O exposures while the AT group developed an initial hyperthermia followed by a return of core temperature to control levels indicative of full tolerance development. By the second N2O exposure, the II group breathing N2O became hyperthermic relative to the placebo control group and this hyperthermia persisted throughout the multiple N2O exposures. Conclusions: Individual differences in initial drug sensitivity and acute tolerance development predict different patterns of chronic tolerance. The hypothesis is suggested that individual differences in opponent adaptive responses may mediate this relationship. PMID:15778887

Triggering collapse of the presolar dense cloud core and injecting short-lived radioisotopes with a shock wave. III. Rotating three-dimensional cloud cores

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boss, Alan P.; Keiser, Sandra A., E-mail: boss@dtm.ciw.edu

2014-06-10

A key test of the supernova triggering and injection hypothesis for the origin of the solar system's short-lived radioisotopes is to reproduce the inferred initial abundances of these isotopes. We present here the most detailed models to date of the shock wave triggering and injection process, where shock waves with varied properties strike fully three-dimensional, rotating, dense cloud cores. The models are calculated with the FLASH adaptive mesh hydrodynamics code. Three different outcomes can result: triggered collapse leading to fragmentation into a multiple protostar system; triggered collapse leading to a single protostar embedded in a protostellar disk; or failure tomore » undergo dynamic collapse. Shock wave material is injected into the collapsing clouds through Rayleigh-Taylor fingers, resulting in initially inhomogeneous distributions in the protostars and protostellar disks. Cloud rotation about an axis aligned with the shock propagation direction does not increase the injection efficiency appreciably, as the shock parameters were chosen to be optimal for injection even in the absence of rotation. For a shock wave from a core-collapse supernova, the dilution factors for supernova material are in the range of ∼10{sup –4} to ∼3 × 10{sup –4}, in agreement with recent laboratory estimates of the required amount of dilution for {sup 60}Fe and {sup 26}Al. We conclude that a type II supernova remains as a promising candidate for synthesizing the solar system's short-lived radioisotopes shortly before their injection into the presolar cloud core by the supernova's remnant shock wave.« less

DIFFERENT DYNAMICAL AGES FOR THE TWO YOUNG AND COEVAL LMC STAR CLUSTERS, NGC 1805 AND NGC 1818, IMPRINTED ON THEIR BINARY POPULATIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geller, Aaron M.; Grijs, Richard de; Li, Chengyuan

2015-05-20

The two Large Magellanic Cloud star clusters, NGC 1805 and NGC 1818, are approximately the same chronological age (∼30 Myr), but show different radial trends in binary frequency. The F-type stars (1.3–2.2 M{sub ⊙}) in NGC 1818 have a binary frequency that decreases toward the core, while the binary frequency for stars of similar mass in NGC 1805 is flat with radius, or perhaps bimodal (with a peak in the core). We show here, through detailed N-body modeling, that both clusters could have formed with the same primordial binary frequency and with binary orbital elements and masses drawn from themore » same distributions (defined from observations of open clusters and the field of our Galaxy). The observed radial trends in binary frequency for both clusters are best matched with models that have initial substructure. Furthermore, both clusters may be evolving along a very similar dynamical sequence, with the key difference that NGC 1805 is dynamically older than NGC 1818. The F-type binaries in NGC 1818 still show evidence of an initial period of rapid dynamical disruptions (which occur preferentially in the core), while NGC 1805 has already begun to recover a higher core binary frequency, owing to mass segregation (which will eventually produce a distribution in binary frequency that rises only toward the core, as is observed in old Milky Way star clusters). This recovery rate increases for higher-mass binaries, and therefore even at one age in one cluster, we predict a similar dynamical sequence in the radial distribution of the binary frequency as a function of binary primary mass.« less

Purification and DNA-binding properties of RNA polymerase from Bacillus subtilis.

PubMed

Giacomoni, P U

1980-05-01

Four RNA-polymerizing activities having different subunit composition can be purified from uninfected and from SPO1-infected Bacillus subtilis. Lysozyme and sodium deoxycholate are used for lysing the cells. Polymin P is used for precipitating nucleic acids and DEAE-cellulose chromatography allows separation of enzymatic activity from the residual Polymin P. After these common steps, one can purify core + sigma + delta by chromatography on single-stranded DNA-agarose followed by gel filtration while pure core + sigma can be obtained by chromatography on double-stranded DNA cellulose. Core + delta is obtained by high-salt sucrose/glycerol gradient centrifugation. The host enzyme modified by the product of gene 28 of phage SPO1 can be purified from SPO1 infected cells by chromatography on DNA cellulose (or CNA agarose) followed by chromatography on phosphocellulose. The pH and salt dependance of the initial rate of RNA synthesis of core + sigma has been investigated using SPO1 and SPP1 DNA as templates. The optimum pH for the initial rate of transcription is 8.2 at 30 degrees C in 50 mM N,N-bis(2-hydroxyethyl)glycine buffer, and the optimum Na+ concentration is between 0.1 and 0.15 M. The kinetics of formation and of dissociation of non-filterable complexes between SPP1 DNA and core + sigma have been analyzed at different cationic concentrations. The value of the rate constant of dissociation in 0.1 M NaCl at 30 degrees C is kd = 2.16 x 10(-4) S-1. The value of the rate constant of association, under the same conditions, is ka = 5.5 x 10(8) M-1 S-1; this value is compatible with a diffusion-controlled reaction for promoter selection.

Efficient computation of the phylogenetic likelihood function on multi-gene alignments and multi-core architectures.

PubMed

Stamatakis, Alexandros; Ott, Michael

2008-12-27

The continuous accumulation of sequence data, for example, due to novel wet-laboratory techniques such as pyrosequencing, coupled with the increasing popularity of multi-gene phylogenies and emerging multi-core processor architectures that face problems of cache congestion, poses new challenges with respect to the efficient computation of the phylogenetic maximum-likelihood (ML) function. Here, we propose two approaches that can significantly speed up likelihood computations that typically represent over 95 per cent of the computational effort conducted by current ML or Bayesian inference programs. Initially, we present a method and an appropriate data structure to efficiently compute the likelihood score on 'gappy' multi-gene alignments. By 'gappy' we denote sampling-induced gaps owing to missing sequences in individual genes (partitions), i.e. not real alignment gaps. A first proof-of-concept implementation in RAXML indicates that this approach can accelerate inferences on large and gappy alignments by approximately one order of magnitude. Moreover, we present insights and initial performance results on multi-core architectures obtained during the transition from an OpenMP-based to a Pthreads-based fine-grained parallelization of the ML function.

Deepwater Gulf of Mexico turbidites -- Compaction effects on porosity and permeability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ostermeier, R.M.

1995-06-01

The deepwater Gulf of Mexico is now a major area of activity for the US oil industry. Compaction causes particular concern because most prospective deepwater reservoirs are highly geo-pressured and many have limited aquifer support; water injection may also be problematic. To address some of the issues associated with compaction, the authors initiated a special core-analysis program to study compaction effects on turbidite sand porosity and permeability specifically. This program also addressed a number of subsidiary but no less important issues, such as sample characterization and quality, sample preparation, and test procedures. These issues are particularly pertinent, because Gulf ofmore » Mexico turbidites are generally unconsolidated, loose sands, and are thus susceptible to a whole array of potentially serious core-disturbing processes. One key result of the special core analysis program is that turbidite compressibilities exhibit large variations in both magnitude and stress dependence. These variations correlate with creep response in the laboratory measurements. The effects of compaction on permeability are significant. To eliminate complicating effects caused by fines movement, the authors made oil flow measurements at initial water saturation. The measurements indicate compaction reduces permeability four to five times more than porosity on a relative basis.« less

Fundamental approaches for analysis thermal hydraulic parameter for Puspati Research Reactor

NASA Astrophysics Data System (ADS)

Hashim, Zaredah; Lanyau, Tonny Anak; Farid, Mohamad Fairus Abdul; Kassim, Mohammad Suhaimi; Azhar, Noraishah Syahirah

2016-01-01

The 1-MW PUSPATI Research Reactor (RTP) is the one and only nuclear pool type research reactor developed by General Atomic (GA) in Malaysia. It was installed at Malaysian Nuclear Agency and has reached the first criticality on 8 June 1982. Based on the initial core which comprised of 80 standard TRIGA fuel elements, the very fundamental thermal hydraulic model was investigated during steady state operation using the PARET-code. The main objective of this paper is to determine the variation of temperature profiles and Departure of Nucleate Boiling Ratio (DNBR) of RTP at full power operation. The second objective is to confirm that the values obtained from PARET-code are in agreement with Safety Analysis Report (SAR) for RTP. The code was employed for the hot and average channels in the core in order to calculate of fuel's center and surface, cladding, coolant temperatures as well as DNBR's values. In this study, it was found that the results obtained from the PARET-code showed that the thermal hydraulic parameters related to safety for initial core which was cooled by natural convection was in agreement with the designed values and safety limit in SAR.

Macrophages influence a competition of contact guidance and chemotaxis for fibroblast alignment in a fibrin gel coculture assay.

PubMed

Bromberek, B A; Enever, P A J; Shreiber, D I; Caldwell, M D; Tranquillo, R T

2002-05-01

Rat dermal fibroblasts were dispersed initially in the outer shell of a fibrin gel sphere, while the inner core either was devoid of cells or contained peritoneal exudate cells (primarily macrophages), thereby mimicking the inflammatory phase of wound healing. The fibroblasts compacted floating fibrin microspheres over time. In the absence of macrophages, the initial distribution of fibroblasts (only in the shell) induced circumferential alignment of fibrin fibrils via compaction of the shell relative to the core. The aligned fibrils created a contact guidance field, which was manifested by strong circumferential alignment of the fibroblasts. However, in the presence of macrophages, the fibroblasts exhibited more radial alignment despite the simultaneous contact guidance field in the circumferential direction associated with compaction. This was attributed to a chemotactic gradient emanating from the core due to a putative factor(s) released by the macrophages. The presence of a radial chemotactic stimulus was supported by the finding of even greater radial alignment when fibrin microspheres were embedded in an agarose-fibrin gel that abolished compaction and consequently the contact guidance field. Our assay permits the simulation of tissue morphogenetic processes that involve cell guidance phenomena and tractional restructuring of the extracellular matrix.

The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates.

PubMed

Jones, Grant D; Williams, Ernest P; Place, Allen R; Jagus, Rosemary; Bachvaroff, Tsvetan R

2015-02-10

Dinoflagellates are eukaryotes with unusual cell biology and appear to rely on translational rather than transcriptional control of gene expression. The eukaryotic translation initiation factor 4E (eIF4E) plays an important role in regulating gene expression because eIF4E binding to the mRNA cap is a control point for translation. eIF4E is part of an extended, eukaryote-specific family with different members having specific functions, based on studies of model organisms. Dinoflagellate eIF4E diversity could provide a mechanism for dinoflagellates to regulate gene expression in a post-transcriptional manner. Accordingly, eIF4E family members from eleven core dinoflagellate transcriptomes were surveyed to determine the diversity and phylogeny of the eIF4E family in dinoflagellates and related lineages including apicomplexans, ciliates and heterokonts. The survey uncovered eight to fifteen (on average eleven) different eIF4E family members in each core dinoflagellate species. The eIF4E family members from heterokonts and dinoflagellates segregated into three clades, suggesting at least three eIF4E cognates were present in their common ancestor. However, these three clades are distinct from the three previously described eIF4E classes, reflecting diverse approaches to a central eukaryotic function. Heterokonts contain four clades, ciliates two and apicomplexans only a single recognizable eIF4E clade. In the core dinoflagellates, the three clades were further divided into nine sub-clades based on the phylogenetic analysis and species representation. Six of the sub-clades included at least one member from all eleven core dinoflagellate species, suggesting duplication in their shared ancestor. Conservation within sub-clades varied, suggesting different selection pressures. Phylogenetic analysis of eIF4E in core dinoflagellates revealed complex layering of duplication and conservation when compared to other eukaryotes. Our results suggest that the diverse eIF4E family in core dinoflagellates may provide a toolkit to enable selective translation as a strategy for controlling gene expression in these enigmatic eukaryotes.

Chicxulub Impact Crater and Yucatan Carbonate Platform - Stratigraphy and Petrography of PEMEX Borehole Cores

NASA Astrophysics Data System (ADS)

Gutierrez-Cirlos, A. G.; Perez-Drago, G.; Perez-Cruz, L.; Urrutia-Fucugauchi, J.

2008-12-01

Chicxulub impact crater is the best preserved of the three large multi-ring structures documented in the terrestrial record. Chicxulub, formed 65 Ma ago, is associated with the Cretaceous/Tertiary (K/T) boundary layer and the impact related to the organism extinctions and events marking the boundary. The crater is buried under Tertiary sediments in the Yucatan carbonate platform in the southern Gulf of Mexico. The structure was initially recognized from gravity and magnetic anomalies in the PEMEX exploration surveys of the northwestern Yucatan peninsula. The exploration program included eight deep boreholes completed from 1952 through the 1970s. The investigations showing Chicxulub as a large complex impact crater formed at the K/T boundary have relayed on the PEMEX decades-long exploration program. However, despite frequent use of PEMEX information and core samples, significant parts of the database and cores remain to be evaluated, analyzed and incorporated with results from recent efforts. Access to PEMEX Core Repository has permitted to study the cores and collect new samples from some of the boreholes. We analyzed cores from Yucatan-6, Chicxulub-1, Sacapuc-1, Ticul-1, Yucatan-1 and Yucatan-4 boreholes to make new detailed stratigraphic correlations and petrographic characterization, using information from PEMEX database and the recent studies. In C-1 cores, breccias show 4-8 cm clasts of fine grained altered melt dispersed in a medium to coarse grained matrix composed of pyroxene and feldspar with little macroscopic alteration. Clasts contain 0.2 to 0.1 cm fragments of silicate material (basement) that show variable degrees of digestion. Melt samples from C-1 N10 comes from interval 1,393-1,394 m, and show a fine-to-medium grained coherent microcrystalline groundmass. Melt and breccias in Y-6 extend from about 1,100 m to more than 1,400 m. Sequence is well sorted, with an apparent gradation in both the lithic and melt clasts. In this presentation we report on initial results from this new joint project for the carbonate sequences and impact lithologies.

Initial Results on the Meteoritic Component of new Sediment Cores Containing Deposits of the Eltanin Impact Event

NASA Technical Reports Server (NTRS)

Kyte, Frank T.; Gersonde, Rainer; Kuhn, Gerhard

2002-01-01

The late Pliocene impact of the Eltanin asteroid is the only known asteroid impact in a deep- ocean (-5 km) basin . This was first discovered in 1981 as an Ir anomaly in sediment cores collected by the USNS Eltanin in 1965. In 1995, Polarstern expedition ANT XII/4 made the first geological survey of the suspected impact region. Three sediment cores sampled around the San Martin seamounts (approx. 57.5 S, 91 W) contained well-preserved impact deposits that include disturbed ocean sediments and meteoritic impact ejecta. The latter is composed of shock-melted asteroidal materials and unmelted meteorites. In 2001, the FS Polarstern returned to the impact area during expedition ANT XVIIU5a. At least 16 cores were recovered that contain ejecta deposits. These cores and geophysical data from the expedition can be used to map the effects of the impact over a region of about 80,000 square km. To date we have measured Ir concentrations in sediments from seven of the new cores and preliminary data should be available for a few more by the time of the meeting. Our initial interpretation of these data is that there is a region in the vicinity of the San Martin Seamounts comprising at least 20,000 square km in which the average amount of meteoritic material deposited was more than 1 g per square cm. This alone is enough material to support a 500 m asteroid. Beyond this is a region of about 60,000 square km, mostly to the north and west, where the amount of ejecta probably averages about 0.2 g per square cm. Another 400 km to the east, USNS Eltanin core E10-2 has about 0.05 g per square cm, so we know that ejecta probably occurs across more than a million square km of ocean floor. A key to future exploration of this impact is to find evidence of the ejecta at more sites distant from the seamounts. We currently have almost no data from regions to the west or south of the San Martin seamounts.

Modeling Radicalization Phenomena in Heterogeneous Populations.

PubMed

Galam, Serge; Javarone, Marco Alberto

2016-01-01

The phenomenon of radicalization is investigated within a mixed population composed of core and sensitive subpopulations. The latest includes first to third generation immigrants. Respective ways of life may be partially incompatible. In case of a conflict core agents behave as inflexible about the issue. In contrast, sensitive agents can decide either to live peacefully adjusting their way of life to the core one, or to oppose it with eventually joining violent activities. The interplay dynamics between peaceful and opponent sensitive agents is driven by pairwise interactions. These interactions occur both within the sensitive population and by mixing with core agents. The update process is monitored using a Lotka-Volterra-like Ordinary Differential Equation. Given an initial tiny minority of opponents that coexist with both inflexible and peaceful agents, we investigate implications on the emergence of radicalization. Opponents try to turn peaceful agents to opponents driving radicalization. However, inflexible core agents may step in to bring back opponents to a peaceful choice thus weakening the phenomenon. The required minimum individual core involvement to actually curb radicalization is calculated. It is found to be a function of both the majority or minority status of the sensitive subpopulation with respect to the core subpopulation and the degree of activeness of opponents. The results highlight the instrumental role core agents can have to hinder radicalization within the sensitive subpopulation. Some hints are outlined to favor novel public policies towards social integration.

MIMI: multimodality, multiresource, information integration environment for biomedical core facilities.

PubMed

Szymanski, Jacek; Wilson, David L; Zhang, Guo-Qiang

2009-10-01

The rapid expansion of biomedical research has brought substantial scientific and administrative data management challenges to modern core facilities. Scientifically, a core facility must be able to manage experimental workflow and the corresponding set of large and complex scientific data. It must also disseminate experimental data to relevant researchers in a secure and expedient manner that facilitates collaboration and provides support for data interpretation and analysis. Administratively, a core facility must be able to manage the scheduling of its equipment and to maintain a flexible and effective billing system to track material, resource, and personnel costs and charge for services to sustain its operation. It must also have the ability to regularly monitor the usage and performance of its equipment and to provide summary statistics on resources spent on different categories of research. To address these informatics challenges, we introduce a comprehensive system called MIMI (multimodality, multiresource, information integration environment) that integrates the administrative and scientific support of a core facility into a single web-based environment. We report the design, development, and deployment experience of a baseline MIMI system at an imaging core facility and discuss the general applicability of such a system in other types of core facilities. These initial results suggest that MIMI will be a unique, cost-effective approach to addressing the informatics infrastructure needs of core facilities and similar research laboratories.

Confocal fluorescence microscopy for rapid evaluation of invasive tumor cellularity of inflammatory breast carcinoma core needle biopsies.

PubMed

Dobbs, Jessica; Krishnamurthy, Savitri; Kyrish, Matthew; Benveniste, Ana Paula; Yang, Wei; Richards-Kortum, Rebecca

2015-01-01

Tissue sampling is a problematic issue for inflammatory breast carcinoma, and immediate evaluation following core needle biopsy is needed to evaluate specimen adequacy. We sought to determine if confocal fluorescence microscopy provides sufficient resolution to evaluate specimen adequacy by comparing invasive tumor cellularity estimated from standard histologic images to invasive tumor cellularity estimated from confocal images of breast core needle biopsy specimens. Grayscale confocal fluorescence images of breast core needle biopsy specimens were acquired following proflavine application. A breast-dedicated pathologist evaluated invasive tumor cellularity in histologic images with hematoxylin and eosin staining and in grayscale and false-colored confocal images of cores. Agreement between cellularity estimates was quantified using a kappa coefficient. 23 cores from 23 patients with suspected inflammatory breast carcinoma were imaged. Confocal images were acquired in an average of less than 2 min per core. Invasive tumor cellularity estimated from histologic and grayscale confocal images showed moderate agreement by kappa coefficient: κ = 0.48 ± 0.09 (p < 0.001). Grayscale confocal images require less than 2 min for acquisition and allow for evaluation of invasive tumor cellularity in breast core needle biopsy specimens with moderate agreement to histologic images. We show that confocal fluorescence microscopy can be performed immediately following specimen acquisition and could indicate the need for additional biopsies at the initial visit.

Modeling Radicalization Phenomena in Heterogeneous Populations

PubMed Central

2016-01-01

The phenomenon of radicalization is investigated within a mixed population composed of core and sensitive subpopulations. The latest includes first to third generation immigrants. Respective ways of life may be partially incompatible. In case of a conflict core agents behave as inflexible about the issue. In contrast, sensitive agents can decide either to live peacefully adjusting their way of life to the core one, or to oppose it with eventually joining violent activities. The interplay dynamics between peaceful and opponent sensitive agents is driven by pairwise interactions. These interactions occur both within the sensitive population and by mixing with core agents. The update process is monitored using a Lotka-Volterra-like Ordinary Differential Equation. Given an initial tiny minority of opponents that coexist with both inflexible and peaceful agents, we investigate implications on the emergence of radicalization. Opponents try to turn peaceful agents to opponents driving radicalization. However, inflexible core agents may step in to bring back opponents to a peaceful choice thus weakening the phenomenon. The required minimum individual core involvement to actually curb radicalization is calculated. It is found to be a function of both the majority or minority status of the sensitive subpopulation with respect to the core subpopulation and the degree of activeness of opponents. The results highlight the instrumental role core agents can have to hinder radicalization within the sensitive subpopulation. Some hints are outlined to favor novel public policies towards social integration. PMID:27166677

Preliminary engineering design of sodium-cooled CANDLE core

NASA Astrophysics Data System (ADS)

Takaki, Naoyuki; Namekawa, Azuma; Yoda, Tomoyuki; Mizutani, Akihiko; Sekimoto, Hiroshi

2012-06-01

The CANDLE burning process is characterized by the autonomous shifting of burning region with constant reactivity and constant spacial power distribution. Evaluations of such critical burning process by using widely used neutron diffusion and burning codes under some realistic engineering constraints are valuable to confirm the technical feasibility of the CANDLE concept and to put the idea into concrete core design. In the first part of this paper, it is discussed that whether the sustainable and stable CANDLE burning process can be reproduced even by using conventional core analysis tools such as SLAROM and CITATION-FBR. As a result, it is certainly possible to demonstrate it if the proper core configuration and initial fuel composition required as CANDLE core are applied to the analysis. In the latter part, an example of a concrete image of sodium cooled, metal fuel, 2000MWt rating CANDLE core has been presented by assuming an emerging inevitable technology of recladding. The core satisfies engineering design criteria including cladding temperature, pressure drop, linear heat rate, and cumulative damage fraction (CDF) of cladding, fast neutron fluence and sodium void reactivity which are defined in the Japanese FBR design project. It can be concluded that it is feasible to design CADLE core by using conventional codes while satisfying some realistic engineering design constraints assuming that recladding at certain time interval is technically feasible.

Comparison of Histologic Core Portions Acquired from a Core Biopsy Needle and a Conventional Needle in Solid Mass Lesions: A Prospective Randomized Trial.

PubMed

Lee, Ban Seok; Cho, Chang-Min; Jung, Min Kyu; Jang, Jung Sik; Bae, Han Ik

2017-07-15

The superiority of endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) over EUS-guided fine needle aspiration (EUS-FNA) remains controversial. Given the lack of studies analyzing histologic specimens acquired from EUS-FNB or EUS-FNA, we compared the proportion of the histologic core obtained from both techniques. A total of 58 consecutive patients with solid mass lesions were enrolled and randomly assigned to the EUS-FNA or EUS-FNB groups. The opposite needle was used after the failure of core tissue acquisition using the initial needle with up to three passes. Using computerized analyses of the scanned histologic slide, the overall area and the area of the histologic core portion in specimens obtained by the two techniques were compared. No significant differences were identified between the two groups with respect to demographic and clinical characteristics. Fewer needle passes were required to obtain core specimens in the FNB group (p<0.001). There were no differences in the proportion of histologic core (11.8%±19.5% vs 8.0%±11.1%, p=0.376) or in the diagnostic accuracy (80.6% vs 81.5%, p=0.935) between two groups. The proportion of histologic core and the diagnostic accuracy were comparable between the FNB and FNA groups. However, fewer needle passes were required to establish an accurate diagnosis in EUS-FNB.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, William R.; Lee, John C.; baxter, Alan

Information and measured data from the intial Fort St. Vrain (FSV) high temperature gas reactor core is used to develop a benchmark configuration to validate computational methods for analysis of a full-core, commercial HTR configuration. Large uncertainties in the geometry and composition data for the FSV fuel and core are identified, including: (1) the relative numbers of fuel particles for the four particle types, (2) the distribution of fuel kernel diameters for the four particle types, (3) the Th:U ratio in the initial FSV core, (4) and the buffer thickness for the fissile and fertile particles. Sensitivity studies were performedmore » to assess each of these uncertainties. A number of methods were developed to assist in these studies, including: (1) the automation of MCNP5 input files for FSV using Python scripts, (2) a simple method to verify isotopic loadings in MCNP5 input files, (3) an automated procedure to conduct a coupled MCNP5-RELAP5 analysis for a full-core FSV configuration with thermal-hydraulic feedback, and (4) a methodology for sampling kernel diameters from arbitrary power law and Gaussian PDFs that preserved fuel loading and packing factor constraints. A reference FSV fuel configuration was developed based on having a single diameter kernel for each of the four particle types, preserving known uranium and thorium loadings and packing factor (58%). Three fuel models were developed, based on representing the fuel as a mixture of kernels with two diameters, four diameters, or a continuous range of diameters. The fuel particles were put into a fuel compact using either a lattice-bsed approach or a stochastic packing methodology from RPI, and simulated with MCNP5. The results of the sensitivity studies indicated that the uncertainties in the relative numbers and sizes of fissile and fertile kernels were not important nor were the distributions of kernel diameters within their diameter ranges. The uncertainty in the Th:U ratio in the intial FSV core was found to be important with a crude study. The uncertainty in the TRISO buffer thickness was estimated to be unimportant but the study was not conclusive. FSV fuel compacts and a regular FSV fuel element were analyzed with MCNP5 and compared with predictions using a modified version of HELIOS that is capable of analyzing TRISO fuel configurations. The HELIOS analyses were performed by SSP. The eigenvalue discrepancies between HELIOS and MCNP5 are currently on the order of 1% but these are still being evaluated. Full-core FSV configurations were developed for two initial critical configurations - a cold, clean critical loading and a critical configuration at 70% power. MCNP5 predictions are compared to experimental data and the results are mixed. Analyses were also done for the pulsed neutron experiments that were conducted by GA for the initial FSV core. MCNP5 was used to model these experiments and reasonable agreement with measured results has been observed.« less

Alzheimer’s Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans

PubMed Central

Saykin, Andrew J.; Shen, Li; Foroud, Tatiana M.; Potkin, Steven G.; Swaminathan, Shanker; Kim, Sungeun; Risacher, Shannon L.; Nho, Kwangsik; Huentelman, Matthew J.; Craig, David W.; Thompson, Paul M.; Stein, Jason L.; Moore, Jason H.; Farrer, Lindsay A.; Green, Robert C.; Bertram, Lars; Jack, Clifford R.; Weiner, Michael W.

2010-01-01

The role of the Alzheimer’s Disease Neuroimaging Initiative Genetics Core is to facilitate the investigation of genetic influences on disease onset and trajectory as reflected in structural, functional, and molecular imaging changes; fluid biomarkers; and cognitive status. Major goals include (1) blood sample processing, genotyping, and dissemination, (2) genome-wide association studies (GWAS) of longitudinal phenotypic data, and (3) providing a central resource, point of contact and planning group for genetics within Alzheimer’s Disease Neuroimaging Initiative. Genome-wide array data have been publicly released and updated, and several neuroimaging GWAS have recently been reported examining baseline magnetic resonance imaging measures as quantitative phenotypes. Other preliminary investigations include copy number variation in mild cognitive impairment and Alzheimer’s disease and GWAS of baseline cerebrospinal fluid biomarkers and longitudinal changes on magnetic resonance imaging. Blood collection for RNA studies is a new direction. Genetic studies of longitudinal phenotypes hold promise for elucidating disease mechanisms and risk, development of therapeutic strategies, and refining selection criteria for clinical trials. PMID:20451875

When can I start pointe work? Guidelines for initiating pointe training.

PubMed

Weiss, David S; Rist, Rachel Anne; Grossman, Gayanne

2009-01-01

The initiation of pointe training for dance students should be determined after careful evaluation of a number of factors. These include: the dance student's stage of physical development; the quality of her (or his) trunk, abdominal and pelvic control ("core" stability); the alignment of her legs (hip-knee-ankle-foot); the strength and flexibility of her feet and ankles; and the duration and frequency of her dance training. For students who meet the requirements related to all of these factors, began ballet training at age eight or later, and who are taking ballet class at least twice per week, pointe work should be initiated in the fourth year of training. Students with poor core stability or hypermobility of the feet and ankles may require additional strengthening to allow them to safely begin pointe training. For those who are only taking ballet classes once per week, or who are not truly pre-professional, pointe training should be discouraged. No student with insufficient ankle and foot plantar flexion range of motion or with poor lower extremity alignment should be allowed to do pointe work.

A Comparative Study between a Failed and a Successful Eruption Initiated from the Same Polarity Inversion Line in AR 11387

NASA Astrophysics Data System (ADS)

Liu, Lijuan; Wang, Yuming; Zhou, Zhenjun; Dissauer, Karin; Temmer, Manuela; Cui, Jun

2018-05-01

In this paper, we analyzed a failed and a successful eruption that initiated from the same polarity inversion line within NOAA AR 11387 on 2011 December 25. They both started from a reconnection between sheared arcades, with distinct pre-eruption conditions and eruption details: before the failed one, the magnetic fields of the core region had a weaker non-potentiality; the external fields had a similar critical height for torus instability, and a similar local torus-stable region, but a larger magnetic flux ratio (of low corona and near-surface region) compared to the successful one. During the failed eruption, a smaller Lorentz force impulse was exerted on the outward ejecta; the ejecta had a much slower rising speed. Factors that might lead to the initiation of the failed eruption are identified: (1) a weaker non-potentiality of the core region, and a smaller Lorentz force impulse gave the ejecta a small momentum; (2) the large flux ratio, and the local torus-stable region in the corona provided strong confinements that made the erupting structure regain an equilibrium state.

Tensile property improvement of TWIP-cored three-layer steel sheets fabricated by hot-roll-bonding with low-carbon steel or interstitial-free steel

PubMed Central

Park, Jaeyeong; Kim, Jung-Su; Kang, Minju; Sohn, Seok Su; Cho, Won Tae; Kim, Hyoung Seop; Lee, Sunghak

2017-01-01

TWIP-cored three-layer steel sheets were newly fabricated by hot rolling of TWIP steel sheet surrounded by low-carbon (LC) or interstitial-free (IF) steel sheets. TWIP/LC or TWIP/IF interfaces were well bonded without pores or voids, while a few pearlites were thinly formed along the interfaces. The strengths and elongation of the TWIP-cored sheets increased as the volume fraction of TWIP-cored region increased, and were also well matched with the ones calculated by a rule of mixtures based on volume fraction or force fraction. According to digital image correlation and electron back-scatter diffraction analyses, very high strain hardening effect in the initial deformation stage and active twin formation in the interfacial region beneficially affected the overall homogeneous deformation in the TWIP-cored sheets without any yield point phenomenon occurring in the LC sheet and serrations occurring in the TWIP sheet, respectively. These TWIP-cored sheets can cover a wide range of yield strength, tensile strength, and ductility levels, e.g., 320~498 MPa, 545~878 MPa, and 48~54%, respectively, by controlling the volume fraction of TWIP-cored region, and thus present new applications to multi-functional automotive steel sheets requiring excellent properties. PMID:28067318

Tensile property improvement of TWIP-cored three-layer steel sheets fabricated by hot-roll-bonding with low-carbon steel or interstitial-free steel

NASA Astrophysics Data System (ADS)

Park, Jaeyeong; Kim, Jung-Su; Kang, Minju; Sohn, Seok Su; Cho, Won Tae; Kim, Hyoung Seop; Lee, Sunghak

2017-01-01

TWIP-cored three-layer steel sheets were newly fabricated by hot rolling of TWIP steel sheet surrounded by low-carbon (LC) or interstitial-free (IF) steel sheets. TWIP/LC or TWIP/IF interfaces were well bonded without pores or voids, while a few pearlites were thinly formed along the interfaces. The strengths and elongation of the TWIP-cored sheets increased as the volume fraction of TWIP-cored region increased, and were also well matched with the ones calculated by a rule of mixtures based on volume fraction or force fraction. According to digital image correlation and electron back-scatter diffraction analyses, very high strain hardening effect in the initial deformation stage and active twin formation in the interfacial region beneficially affected the overall homogeneous deformation in the TWIP-cored sheets without any yield point phenomenon occurring in the LC sheet and serrations occurring in the TWIP sheet, respectively. These TWIP-cored sheets can cover a wide range of yield strength, tensile strength, and ductility levels, e.g., 320~498 MPa, 545~878 MPa, and 48~54%, respectively, by controlling the volume fraction of TWIP-cored region, and thus present new applications to multi-functional automotive steel sheets requiring excellent properties.

Tensile property improvement of TWIP-cored three-layer steel sheets fabricated by hot-roll-bonding with low-carbon steel or interstitial-free steel.

PubMed

Park, Jaeyeong; Kim, Jung-Su; Kang, Minju; Sohn, Seok Su; Cho, Won Tae; Kim, Hyoung Seop; Lee, Sunghak

2017-01-09

TWIP-cored three-layer steel sheets were newly fabricated by hot rolling of TWIP steel sheet surrounded by low-carbon (LC) or interstitial-free (IF) steel sheets. TWIP/LC or TWIP/IF interfaces were well bonded without pores or voids, while a few pearlites were thinly formed along the interfaces. The strengths and elongation of the TWIP-cored sheets increased as the volume fraction of TWIP-cored region increased, and were also well matched with the ones calculated by a rule of mixtures based on volume fraction or force fraction. According to digital image correlation and electron back-scatter diffraction analyses, very high strain hardening effect in the initial deformation stage and active twin formation in the interfacial region beneficially affected the overall homogeneous deformation in the TWIP-cored sheets without any yield point phenomenon occurring in the LC sheet and serrations occurring in the TWIP sheet, respectively. These TWIP-cored sheets can cover a wide range of yield strength, tensile strength, and ductility levels, e.g., 320~498 MPa, 545~878 MPa, and 48~54%, respectively, by controlling the volume fraction of TWIP-cored region, and thus present new applications to multi-functional automotive steel sheets requiring excellent properties.

A rural, community-based suicide awareness and intervention program.

PubMed

Jones, Sharon; Walker, Coralanne; Miles, Alison C J; De Silva, Eve; Zimitat, Craig

2015-01-01

Suicide is a prominent public health issue in rural Australia and specifically in Tasmania, which has one of the highest suicide rates in the country. The Community Response to Eliminating Suicide (CORES) program was developed in rural Tasmania in response to a significant number of suicides over a short period of time. CORES is unique in that it is both a community-based and gatekeeper education model. CORES aims to build and empower communities to take ownership of suicide prevention strategies. It also aims to increase the individual community member's interpersonal skills and awareness of suicide risks, while building peer support and awareness of suicide prevention support services within the community itself. Pre- and post-test surveys after the CORES 1-day suicide awareness and intervention program (SAIP) showed significant increases in levels of comfort and confidence in discussing suicide with those who may be contemplating that action. CORES builds community capital through establishing new connections within communities. Establishment of local executive groups, funding and SAIP are key activities of successful CORES programs in communities around Australia. Over half of the initial leaders are still actively involved after a decade, which reflects positively on the quality and outcomes of the program. This study supports CORES as a beneficial and feasible community-based suicide intervention program for rural communities.

A Cul-3-BTB ubiquitylation pathway regulates junctional levels and asymmetry of core planar polarity proteins

PubMed Central

Strutt, Helen; Searle, Elizabeth; Thomas-MacArthur, Victoria; Brookfield, Rosalind; Strutt, David

2013-01-01

The asymmetric localisation of core planar polarity proteins at apicolateral junctions is required to specify cell polarity in the plane of epithelia. This asymmetric distribution of the core proteins is proposed to require amplification of an initial asymmetry by feedback loops. In addition, generation of asymmetry appears to require the regulation of core protein levels, but the importance of such regulation and the underlying mechanisms is unknown. Here we show that ubiquitylation acts through more than one mechanism to control core protein levels in Drosophila, and that without this regulation cellular asymmetry is compromised. Levels of Dishevelled at junctions are regulated by a Cullin-3-Diablo/Kelch ubiquitin ligase complex, the activity of which is most likely controlled by neddylation. Furthermore, activity of the deubiquitylating enzyme Fat facets is required to maintain Flamingo levels at junctions. Notably, ubiquitylation does not alter the total cellular levels of Dishevelled or Flamingo, but only that of the junctional population. When junctional core protein levels are either increased or decreased by disruption of the ubiquitylation machinery, their asymmetric localisation is reduced and this leads to disruption of planar polarity at the tissue level. Loss of asymmetry by altered core protein levels can be explained by reference to feedback models for amplification of asymmetry. PMID:23487316

The Earliest Phases of Star Formation (EPoS): a Herschel key project. The thermal structure of low-mass molecular cloud cores

NASA Astrophysics Data System (ADS)

Launhardt, R.; Stutz, A. M.; Schmiedeke, A.; Henning, Th.; Krause, O.; Balog, Z.; Beuther, H.; Birkmann, S.; Hennemann, M.; Kainulainen, J.; Khanzadyan, T.; Linz, H.; Lippok, N.; Nielbock, M.; Pitann, J.; Ragan, S.; Risacher, C.; Schmalzl, M.; Shirley, Y. L.; Stecklum, B.; Steinacker, J.; Tackenberg, J.

2013-03-01

Context. The temperature and density structure of molecular cloud cores are the most important physical quantities that determine the course of the protostellar collapse and the properties of the stars they form. Nevertheless, density profiles often rely either on the simplifying assumption of isothermality or on observationally poorly constrained model temperature profiles. The instruments of the Herschel satellite provide us for the first time with both the spectral coverage and the spatial resolution that is needed to directly measure the dust temperature structure of nearby molecular cloud cores. Aims: With the aim of better constraining the initial physical conditions in molecular cloud cores at the onset of protostellar collapse, in particular of measuring their temperature structure, we initiated the guaranteed time key project (GTKP) "The Earliest Phases of Star Formation" (EPoS) with the Herschel satellite. This paper gives an overview of the low-mass sources in the EPoS project, the Herschel and complementary ground-based observations, our analysis method, and the initial results of the survey. Methods: We study the thermal dust emission of 12 previously well-characterized, isolated, nearby globules using FIR and submm continuum maps at up to eight wavelengths between 100 μm and 1.2 mm. Our sample contains both globules with starless cores and embedded protostars at different early evolutionary stages. The dust emission maps are used to extract spatially resolved SEDs, which are then fit independently with modified blackbody curves to obtain line-of-sight-averaged dust temperature and column density maps. Results: We find that the thermal structure of all globules (mean mass 7 M⊙) is dominated by external heating from the interstellar radiation field and moderate shielding by thin extended halos. All globules have warm outer envelopes (14-20 K) and colder dense interiors (8-12 K) with column densities of a few 1022 cm-2. The protostars embedded in some of the globules raise the local temperature of the dense cores only within radii out to about 5000 AU, but do not significantly affect the overall thermal balance of the globules. Five out of the six starless cores in the sample are gravitationally bound and approximately thermally stabilized. The starless core in CB 244 is found to be supercritical and is speculated to be on the verge of collapse. For the first time, we can now also include externally heated starless cores in the Lsmm/Lbol vs. Tbol diagram and find that Tbol < 25 K seems to be a robust criterion to distinguish starless from protostellar cores, including those that only have an embedded very low-luminosity object. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Partially based on observations carried out with the IRAM 30 m Telescope, with the Atacama Pathfinder Experiment (APEX), and with the James Clerk Maxwell Telescope (JCMT). IRAM is supported by INSU/CNRS (France), MPG (Germany) and IGN (Spain). APEX is a collaboration between Max Planck Institut für Radioastronomie (MPIfR), Onsala Space Observatory (OSO), and the European Southern Observatory (ESO). The JCMT is operated by the Joint Astronomy Centre on behalf of the Particle Physics and Astronomy Research Council of the United Kingdom, the Netherlands Association for Scientific Research, and the National Research Council of Canada.Appendices A, B and C are available in electronic form at http://www.aanda.org

Pre-cometary ice composition from hot core chemistry.

PubMed

Tornow, Carmen; Kührt, Ekkehard; Motschmann, Uwe

2005-10-01

Pre-cometary ice located around star-forming regions contains molecules that are pre-biotic compounds or pre-biotic precursors. Molecular line surveys of hot cores provide information on the composition of the ice since it sublimates near these sites. We have combined a hydrostatic hot core model with a complex network of chemical reactions to calculate the time-dependent abundances of molecules, ions, and radicals. The model considers the interaction between the ice and gas phase. It is applied to the Orion hot core where high-mass star formation occurs, and to the solar-mass binary protostar system IRAS 16293-2422. Our calculations show that at the end of the hot core phase both star-forming sites produce the same prebiotic CN-bearing molecules. However, in the Orion hot core these molecules are formed in larger abundances. A comparison of the calculated values with the abundances derived from the observed line data requires a chemically unprocessed molecular cloud as the initial state of hot core evolution. Thus, it appears that these objects are formed at a much younger cloud stage than previously thought. This implies that the ice phase of the young clouds does not contain CN-bearing molecules in large abundances before the hot core has been formed. The pre-biotic molecules synthesized in hot cores cause a chemical enrichment in the gas phase and in the pre-cometary ice. This enrichment is thought to be an important extraterrestrial aspect of the formation of life on Earth and elsewhere.

Developing core elements and checklist items for global hospital antimicrobial stewardship programmes: a consensus approach.

PubMed

Pulcini, C; Binda, F; Lamkang, A S; Trett, A; Charani, E; Goff, D A; Harbarth, S; Hinrichsen, S L; Levy-Hara, G; Mendelson, M; Nathwani, D; Gunturu, R; Singh, S; Srinivasan, A; Thamlikitkul, V; Thursky, K; Vlieghe, E; Wertheim, H; Zeng, M; Gandra, S; Laxminarayan, R

2018-04-03

With increasing global interest in hospital antimicrobial stewardship (AMS) programmes, there is a strong demand for core elements of AMS to be clearly defined on the basis of principles of effectiveness and affordability. To date, efforts to identify such core elements have been limited to Europe, Australia, and North America. The aim of this study was to develop a set of core elements and their related checklist items for AMS programmes that should be present in all hospitals worldwide, regardless of resource availability. A literature review was performed by searching Medline and relevant websites to retrieve a list of core elements and items that could have global relevance. These core elements and items were evaluated by an international group of AMS experts using a structured modified Delphi consensus procedure, using two-phased online in-depth questionnaires. The literature review identified seven core elements and their related 29 checklist items from 48 references. Fifteen experts from 13 countries in six continents participated in the consensus procedure. Ultimately, all seven core elements were retained, as well as 28 of the initial checklist items plus one that was newly suggested, all with ≥80% agreement; 20 elements and items were rephrased. This consensus on core elements for hospital AMS programmes is relevant to both high- and low-to-middle-income countries and could facilitate the development of national AMS stewardship guidelines and adoption by healthcare settings worldwide. Copyright © 2018 European Society of Clinical Microbiology and Infectious Diseases. All rights reserved.

NaF-loaded core-shell PAN-PMMA nanofibers as reinforcements for Bis-GMA/TEGDMA restorative resins.

PubMed

Cheng, Liyuan; Zhou, Xuegang; Zhong, Hong; Deng, Xuliang; Cai, Qing; Yang, Xiaoping

2014-01-01

A kind of core-shell nanofibers containing sodium fluoride (NaF) was produced and used as reinforcing materials for dimethacrylate-based dental restorative resins in this study. The core-shell nanofibers were prepared by coaxial-electrospinning with polyacrylonitrile (PAN) and poly(methyl methacrylate) (PMMA) solutions as core and shell fluids, respectively. The produced PAN-PMMA nanofibers varied in fiber diameter and the thickness of PMMA shell depending on electrospinning parameters. NaF-loaded nanofibers were obtained by incorporating NaF nanocrystals into the core fluid at two loadings (0.8 or 1.0wt.%). Embedment of NaF nanocrystals into the PAN core did not damage the core-shell structure. The addition of PAN-PMMA nanofibers into Bis-GMA/TEGDMA clearly showed the reinforcement due to the good interfacial adhesion between fibers and resin. The flexural strength (Fs) and flexural modulus (Ey) of the composites decreased slightly as the thickness of PMMA shell increasing. Sustained fluoride releases with minor initial burst release were achieved from NaF-loaded core-shell nanofibers and the corresponding composites, which was quite different from the case of embedding NaF nanocrystals into the dental resin directly. The study demonstrated that NaF-loaded PAN-PMMA core-shell nanofibers were not only able to improve the mechanical properties of restorative resin, but also able to provide sustained fluoride release to help in preventing secondary caries. © 2013.

Glycosyltransferase Function in Core 2-Type Protein O Glycosylation▿

PubMed Central

Stone, Erica L.; Ismail, Mohd Nazri; Lee, Seung Ho; Luu, Ying; Ramirez, Kevin; Haslam, Stuart M.; Ho, Samuel B.; Dell, Anne; Fukuda, Minoru; Marth, Jamey D.

2009-01-01

Three glycosyltransferases have been identified in mammals that can initiate core 2 protein O glycosylation. Core 2 O-glycans are abundant among glycoproteins but, to date, few functions for these structures have been identified. To investigate the biological roles of core 2 O-glycans, we produced and characterized mice deficient in one or more of the three known glycosyltransferases that generate core 2 O-glycans (C2GnT1, C2GnT2, and C2GnT3). A role for C2GnT1 in selectin ligand formation has been described. We now report that C2GnT2 deficiency impaired the mucosal barrier and increased susceptibility to colitis. C2GnT2 deficiency also reduced immunoglobulin abundance and resulted in the loss of all core 4 O-glycan biosynthetic activity. In contrast, the absence of C2GnT3 altered behavior linked to reduced thyroxine levels in circulation. Remarkably, elimination of all three C2GnTs was permissive of viability and fertility. Core 2 O-glycan structures were reduced among tissues from individual C2GnT deficiencies and completely absent from triply deficient mice. C2GnT deficiency also induced alterations in I-branching, core 1 O-glycan formation, and O mannosylation. Although the absence of C2GnT and C4GnT activities is tolerable in vivo, core 2 O glycosylation exerts a significant influence on O-glycan biosynthesis and is important in multiple physiological processes. PMID:19349303

Simulating an Exploding Fission-Bomb Core

NASA Astrophysics Data System (ADS)

Reed, Cameron

2016-03-01

A time-dependent desktop-computer simulation of the core of an exploding fission bomb (nuclear weapon) has been developed. The simulation models a core comprising a mixture of two isotopes: a fissile one (such as U-235) and an inert one (such as U-238) that captures neutrons and removes them from circulation. The user sets the enrichment percentage and scattering and fission cross-sections of the fissile isotope, the capture cross-section of the inert isotope, the number of neutrons liberated per fission, the number of ``initiator'' neutrons, the radius of the core, and the neutron-reflection efficiency of a surrounding tamper. The simulation, which is predicated on ordinary kinematics, follows the three-dimensional motions and fates of neutrons as they travel through the core. Limitations of time and computer memory render it impossible to model a real-life core, but results of numerous runs clearly demonstrate the existence of a critical mass for a given set of parameters and the dramatic effects of enrichment and tamper efficiency on the growth (or decay) of the neutron population. The logic of the simulation will be described and results of typical runs will be presented and discussed.

Impact Vaporization of Planetesimal Cores

NASA Astrophysics Data System (ADS)

Kraus, R. G.; Root, S.; Lemke, R. W.; Stewart, S. T.; Jacobsen, S. B.; Mattsson, T. R.

2013-12-01

The degree of mixing and chemical equilibration between the iron cores of planetesimals and the mantle of the growing Earth has important consequences for understanding the end stages of Earth's formation and planet formation in general. At the Sandia Z machine, we developed a new shock-and-release technique to determine the density on the liquid-vapor dome of iron, the entropy on the iron shock Hugoniot, and the criteria for shock-induced vaporization of iron. We find that the critical shock pressure to vaporize iron is 507(+65,-85) GPa and show that decompression from a 15 km/s impact will initiate vaporization of iron cores, which is a velocity that is readily achieved at the end stages of planet formation. Vaporization of the iron cores increases dispersal of planetesimal cores, enables more complete chemical equilibration of the planetesimal cores with Earth's mantle, and reduces the highly siderophile element abundance on the Moon relative to Earth due to the expanding iron vapor exceeding the Moon's escape velocity. Sandia National Laboratories is a multiprogram laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Securities Administration under Contract No. DE-AC04-94AL85000.

Core-level photoemission investigation of atomic-fluorine adsorption on GaAs(110)

NASA Astrophysics Data System (ADS)

McLean, A. B.; Terminello, L. J.; McFeely, F. R.

1989-12-01

The adsorption of atomic F on the cleaved GaAs(110) surface has been studied with use of high-resolution core-level photoelectron spectroscopy by exposing the GaAs(110) surfaces to XeF2, which adsorbs dissociatively, leaving atomic F behind. This surface reaction produces two chemically shifted components in the Ga 3d core-level emission which are attributed to an interfacial monofluoride and a stable trifluoride reaction product, respectively. The As 3d core level develops only one chemically shifted component and from its exposure-dependent behavior it is attributed to an interfacial monofluoride. Least-squares analysis of the core-level line shapes revealed that (i) the F bonds to both the anion and the cation , (ii) the GaF3 component (characteristic of strong interfacial reaction) and the surface core-level shifted component (characteristic of a well ordered, atomically clean surface) are present together over a relatively large range of XeF2 exposures, and (iii) it is the initial disruption of the GaAs(110) surface that is the rate-limiting step in this surface reaction. These results are compared with similar studies of Cl and O adsorption on GaAs(110).

Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement.

PubMed

Spuls, P I; Gerbens, L A A; Simpson, E; Apfelbacher, C J; Chalmers, J R; Thomas, K S; Prinsen, C A C; von Kobyletzki, L B; Singh, J A; Williams, H C; Schmitt, J

2017-04-01

The Harmonising Outcome Measures for Eczema (HOME) initiative has defined four core outcome domains for a core outcome set (COS) to be measured in all atopic eczema (AE) trials to ensure cross-trial comparison: clinical signs, symptoms, quality of life and long-term control. The aim of this paper is to report on the consensus process that was used to select the core instrument to consistently assess symptoms in all future AE trials. Following the HOME roadmap, two systematic reviews were performed which identified three instruments that had sufficient evidence of validity, reliability and feasibility to be considered for the final COS. At the fourth international HOME meeting, there was broad consensus among all stakeholders that the Patient-Oriented Eczema Measure (POEM) should be used as the core instrument (87·5% agreed, 9·4% unsure, 3·1% disagreed). All relevant stakeholders are encouraged to use POEM as the chosen instrument to measure the core domain of symptoms in all future AE clinical trials. Other instruments of interest can be used in addition to POEM. © 2016 British Association of Dermatologists.

A wet, heterogeneous lunar interior: Lower mantle and core dynamo evolution

NASA Astrophysics Data System (ADS)

Evans, A. J.; Zuber, M. T.; Weiss, B. P.; Tikoo, S. M.

2014-05-01

While recent analyses of lunar samples indicate the Moon had a core dynamo from at least 4.2-3.56 Ga, mantle convection models of the Moon yield inadequate heat flux at the core-mantle boundary to sustain thermal core convection for such a long time. Past investigations of lunar dynamos have focused on a generally homogeneous, relatively dry Moon, while an initial compositionally stratified mantle is the expected consequence of a postaccretionary lunar magma ocean. Furthermore, recent re-examination of Apollo samples and geophysical data suggests that the Moon contains at least some regions with high water content. Using a finite element model, we investigate the possible consequences of a heterogeneously wet, compositionally stratified interior for the evolution of the Moon. We find that a postoverturn model of mantle cumulates could result in a core heat flux sufficiently high to sustain a dynamo through 2.5 Ga and a maximum surface, dipolar magnetic field strength of less than 1 μT for a 350-km core and near ˜2 μT for a 450-km core. We find that if water was transported or retained preferentially in the deep interior, it would have played a significant role in transporting heat out of the deep interior and reducing the lower mantle temperature. Thus, water, if enriched in the lower mantle, could have influenced core dynamo timing by over 1.0 Gyr and enhanced the vigor of a lunar core dynamo. Our results demonstrate the plausibility of a convective lunar core dynamo even beyond the period currently indicated by the Apollo samples.

Developing core outcome measurement sets for clinical trials: OMERACT filter 2.0.

PubMed

Boers, Maarten; Kirwan, John R; Wells, George; Beaton, Dorcas; Gossec, Laure; d'Agostino, Maria-Antonietta; Conaghan, Philip G; Bingham, Clifton O; Brooks, Peter; Landewé, Robert; March, Lyn; Simon, Lee S; Singh, Jasvinder A; Strand, Vibeke; Tugwell, Peter

2014-07-01

Lack of standardization of outcome measures limits the usefulness of clinical trial evidence to inform health care decisions. This can be addressed by agreeing on a minimum core set of outcome measures per health condition, containing measures relevant to patients and decision makers. Since 1992, the Outcome Measures in Rheumatology (OMERACT) consensus initiative has successfully developed core sets for many rheumatologic conditions, actively involving patients since 2002. Its expanding scope required an explicit formulation of its underlying conceptual framework and process. Literature searches and iterative consensus process (surveys and group meetings) of stakeholders including patients, health professionals, and methodologists within and outside rheumatology. To comprehensively sample patient-centered and intervention-specific outcomes, a framework emerged that comprises three core "Areas," namely Death, Life Impact, and Pathophysiological Manifestations; and one strongly recommended Resource Use. Through literature review and consensus process, core set development for any specific health condition starts by identifying at least one core "Domain" within each of the Areas to formulate the "Core Domain Set." Next, at least one applicable measurement instrument for each core Domain is identified to formulate a "Core Outcome Measurement Set." Each instrument must prove to be truthful (valid), discriminative, and feasible. In 2012, 96% of the voting participants (n=125) at the OMERACT 11 consensus conference endorsed this model and process. The OMERACT Filter 2.0 explicitly describes a comprehensive conceptual framework and a recommended process to develop core outcome measurement sets for rheumatology likely to be useful as a template in other areas of health care. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Unipedal postural stability in nonathletes with core instability after intensive abdominal drawing-in maneuver.

PubMed

Lee, Nam G; You, Joshua Sung H; Kim, Tae H; Choi, Bong S

2015-02-01

The exact neuromechanical nature and relative contribution of the abdominal drawing-in maneuver (ADIM) to postural instability warrants further investigation in uninjured and injured populations. To determine the effects of the ADIM on static core and unipedal postural stability in nonathletes with core instability. Controlled laboratory study. University research laboratory. A total of 19 nonathletes (4 women: age = 22.3 ± 1.3 years, height = 164.0 ± 1.7 cm, mass = 56.0 ± 4.6 kg; 15 men: age = 24.6 ± 2.8 years, height = 172.6 ± 4.7 cm, mass = 66.8 ± 7.6 kg) with core instability. Participants received ADIM training with visual feedback 20 minutes each day for 7 days each week over a 2-week period. Core instability was determined using a prone formal test and measured by a pressure biofeedback unit. Unipedal postural stability was determined by measuring the center-of-pressure sway and associated changes in the abdominal muscle-thickness ratios. Electromyographic activity was measured concurrently in the external oblique, erector spinae, gluteus medius, vastus medialis oblique, tibialis anterior, and medial gastrocnemius muscles. All participants initially were unable to complete the formal test. However, after the 2-week ADIM training period, all participants were able to reduce the pressure biofeedback unit by a range of 4 to 10 mm Hg from an initial 70 mm Hg and maintain it at 60 to 66 mm Hg with minimal activation of the external oblique (t(18) = 3.691, P = .002) and erector spinae (t(18) = 2.823, P = .01) muscles. Monitoring of the pressure biofeedback unit and other muscle activations confirmed that the correct muscle contraction defining the ADIM was accomplished. This core stabilization was well maintained in the unipedal-stance position, as evidenced by a decrease in the center-of-pressure sway measures (t(18) range, 3.953-5.775, P < .001), an increased muscle-thickness ratio for the transverse abdominis (t(18) = -2.327, P = .03), and a reduction in external oblique muscle activity (t(18) = 3.172, P = .005). We provide the first evidence to highlight the positive effects of ADIM training on core and postural stability in nonathletes with core instability.

The FRIGG project: From intermediate galactic scales to self-gravitating cores

NASA Astrophysics Data System (ADS)

Hennebelle, Patrick

2018-03-01

Context. Understanding the detailed structure of the interstellar gas is essential for our knowledge of the star formation process. Aim. The small-scale structure of the interstellar medium (ISM) is a direct consequence of the galactic scales and making the link between the two is essential. Methods: We perform adaptive mesh simulations that aim to bridge the gap between the intermediate galactic scales and the self-gravitating prestellar cores. For this purpose we use stratified supernova regulated ISM magneto-hydrodynamical simulations at the kpc scale to set up the initial conditions. We then zoom, performing a series of concentric uniform refinement and then refining on the Jeans length for the last levels. This allows us to reach a spatial resolution of a few 10-3 pc. The cores are identified using a clump finder and various criteria based on virial analysis. Their most relevant properties are computed and, due to the large number of objects formed in the simulations, reliable statistics are obtained. Results: The cores' properties show encouraging agreements with observations. The mass spectrum presents a clear powerlaw at high masses with an exponent close to ≃-1.3 and a peak at about 1-2 M⊙. The velocity dispersion and the angular momentum distributions are respectively a few times the local sound speed and a few 10-2 pc km s-1. We also find that the distribution of thermally supercritical cores present a range of magnetic mass-to-flux over critical mass-to-flux ratios, typically between ≃0.3 and 3 indicating that they are significantly magnetized. Investigating the time and spatial dependence of these statistical properties, we conclude that they are not significantly affected by the zooming procedure and that they do not present very large fluctuations. The most severe issue appears to be the dependence on the numerical resolution of the core mass function (CMF). While the core definition process may possibly introduce some biases, the peak tends to shift to smaller values when the resolution improves. Conclusions: Our simulations, which use self-consistently generated initial conditions at the kpc scale, produce a large number of prestellar cores from which reliable statistics can be inferred. Preliminary comparisons with observations show encouraging agreements. In particular the inferred CMFs resemble the ones inferred from recent observations. We stress, however, a possible issue with the peak position shifting with numerical resolution.

Intensive Abdominal Drawing-In Maneuver After Unipedal Postural Stability in Nonathletes With Core Instability

PubMed Central

Lee, Nam G.; You, Joshua (Sung) H.; Kim, Tae H.; Choi, Bong S.

2015-01-01

Context: The exact neuromechanical nature and relative contribution of the abdominal drawing-in maneuver (ADIM) to postural instability warrants further investigation in uninjured and injured populations. Objective: To determine the effects of the ADIM on static core and unipedal postural stability in nonathletes with core instability. Design: Controlled laboratory study. Setting: University research laboratory. Patients or Other Participants: A total of 19 nonathletes (4 women: age = 22.3 ± 1.3 years, height = 164.0 ± 1.7 cm, mass = 56.0 ± 4.6 kg; 15 men: age = 24.6 ± 2.8 years, height = 172.6 ± 4.7 cm, mass = 66.8 ± 7.6 kg) with core instability. Intervention(s): Participants received ADIM training with visual feedback 20 minutes each day for 7 days each week over a 2-week period. Main Outcome Measures(s): Core instability was determined using a prone formal test and measured by a pressure biofeedback unit. Unipedal postural stability was determined by measuring the center-of-pressure sway and associated changes in the abdominal muscle-thickness ratios. Electromyographic activity was measured concurrently in the external oblique, erector spinae, gluteus medius, vastus medialis oblique, tibialis anterior, and medial gastrocnemius muscles. Results: All participants initially were unable to complete the formal test. However, after the 2-week ADIM training period, all participants were able to reduce the pressure biofeedback unit by a range of 4 to 10 mm Hg from an initial 70 mm Hg and maintain it at 60 to 66 mm Hg with minimal activation of the external oblique (t18 = 3.691, P = .002) and erector spinae (t18 = 2.823, P = .01) muscles. Monitoring of the pressure biofeedback unit and other muscle activations confirmed that the correct muscle contraction defining the ADIM was accomplished. This core stabilization was well maintained in the unipedal-stance position, as evidenced by a decrease in the center-of-pressure sway measures (t18 range, 3.953–5.775, P < .001), an increased muscle-thickness ratio for the transverse abdominis (t18 = −2.327, P = .03), and a reduction in external oblique muscle activity (t18 = 3.172, P = .005). Conclusions: We provide the first evidence to highlight the positive effects of ADIM training on core and postural stability in nonathletes with core instability. PMID:25531145

Long-Term Changes In The Behaviour Of Jakobshavns Isbrae, West Greenland During The Late Quaternary-Holocene

NASA Astrophysics Data System (ADS)

O'Cofaigh, C.; Jennings, A.; Moros, M.; Andrews, J. T.; Kilfeather, A.; Dowdeswell, J. A.; Richter, T.

2008-12-01

This poster shows the initial results of a joint scientific project to reconstruct the Late Quaternary-Holocene behavior of Jakobshavns Isbrae in central west Greenland, one of the largest ice streams draining the modern Greenland Ice Sheet. The underlying rationale for this research is to determine if recent observed changes to the mass balance of the Greenland Ice Sheet are part of the natural variability in ice-sheet dynamics, or if they relate to anthropogenically-induced climate warming. Key to resolving this question is an understanding of long-term changes in ice sheet behavior during the Late Quaternary and the Holocene. This research will allow assessment of the links between deglaciation and internal and external environmental controls, such as the influence of inflowing Atlantic Water, and will facilitate modelling of the likely future behavior of the GIS. Currently, four marine sediment cores arrayed along a transect from the Disko Bugt Fan to Disko Bay are providing information on changes in sediment flux and sedimentation style, such as abrupt intervals of iceberg-rafting vs. "normal" hemipelagic sedimentation, as well as the paleoceanographic setting and ice sheet-ocean interactions. The cores are being analysed using a variety of proxies including IRD, mineralogy, oxygen isotopes, foraminiferal assemblages, lithofacies analysis and AMS radiocarbon dating. Data are presented from two piston cores from the continental slope at the trough-mouth fan collected during the HE0006 'shakedown' cruise to Baffin Bay and from two gravity cores recovered in 2007 during MS Merian cruise MSM 05/03 to West Greenland. Slope cores contain sequences of laminated facies interpreted as fine-grained turbidites and intervals of massive, bioturbated, hemipelagic mud. The two Merian cores, contributed to this project by the Baltic Sea Research Institute, were collected from the southern entrance to Disko Bugt and the Vaigat channel north of Disko. Radiocarbon dates from the Disko Bugt core show that it contains a full Holocene record of glacial activity and paleoceanography. The poster will present the initial analyses, including radiocarbon dating, XRF compositional data, magnetic susceptibility, lithofacies and IRD analyses determined from x-radiography, foraminiferal analyses and sediment mineralogy. Additional cores and seismic data for this project will be obtained from a cruise on the Canadian research vessel, CSS Hudson in September 2008, and on the British ship, the RRS James Clark Ross in 2009.

What is an Oceanic Core Complex?

NASA Astrophysics Data System (ADS)

Schroeder, T.; Cheadle, M. J.

2007-12-01

The Mid-Atlantic Ridge (MAR) 75km north and south of the 15-20 Fracture Zone (FZ) has produced upper oceanic lithosphere composed dominantly of mantle peridotite with gabbro intrusions. In the absence of diapirism, mantle peridotite can only be exposed on the seafloor by extensional faulting, thus the sea floor geology and bathymetry provide widespread evidence for extensive low-angle faulting. However, only 3% of the seafloor in this region has the domal morphology characteristic of features that have been termed oceanic core complexes; suggesting that other processes, in addition to low-angle faulting, are responsible for the generation of domal core complexes. Most low-angle faults near the 15-20 FZ form gently dipping (10-15°), 10-15km-wide dip slopes on the flanks of 2000m relief bathymetric ridges that are up to 15-40km long (parallel to the MAR). Core recovered from ODP Leg 209 drill holes in these ridges is dominantly peridotite with small (<50m thick) gabbro intrusions. The peridotite is cut by a very high density of brittle faults dipping at both steep and gentle angles. Several holes also contain long-lived shear zones/faults in their upper reaches in which strain was localized at granulite facies, indicated by mylonitic olivine and cpx, and remained active during cooling to sub-greenschist grade, indicated by cross-cutting of progressively lower-grade syn-deformation mineral assemblages. These observations suggest that seafloor spreading is largely accommodated here by slip on low-angle faults, and that these faults are correctly termed detachment faults. Holes drilled into a domal oceanic core complex north of the 15-20 FZ during Leg 209 (ODP Site 1275) recovered dominantly gabbro and not mantle peridotite. This hole is cut by significantly fewer brittle and ductile faults than the peridotite drilled at the non-core-complex detachment fault sites. The detachment fault in the upper reaches (50m) of Site 1275 was localized at temperatures near feldspar's ductile-to-brittle transition, indicated by cataclasis with minor crystal plastic flow in plagioclase, and a lack of pervasive pure-ductile deformation. Amphibole-plagioclase thermometry in the fault yields equilibrium temperatures from 600-650°C, compared to equilibrium temperatures of 750-850°C for the gabbro outside the fault. The presence of talc- chlorite schists and cataclasites cutting the higher-temperature deformation textures indicate fault activity down- temperature from amphibolite through greenschist facies. This core-complex-bounding fault contrasts with the fault that bounds the Atlantis Bank Core Complex on the Southwest Indian Ridge (SWIR). There, the fault is 100m thick and strain was initially localized at granulite grade (>800°C) (Mehl & Hirth, 2007); significantly hotter than the Site 1275 fault. Therefore, the formation of core-complex morphology does not seem to depend on the initial faulting conditions. Both oceanic core complexes that have been drilled besides Site 1275, Atlantis Massif at 30°N (IODP Hole 1309D) on the MAR and Atlantis Bank on the SWIR (ODP Hole 735B), are also comprised dominantly of gabbro. This suggests that magma supply may be an essential requirement for core complex formation and raises the question whether all domal oceanic core complexes are cored by gabbro? We also ask whether the term 'oceanic core complex' should be restricted to these domal features and not applied to detachment-bound, non- domal, peridotite-cored ridges; or if these should be considered two sub-classes of oceanic core complexes.

Children's science learning: A core skills approach.

PubMed

Tolmie, Andrew K; Ghazali, Zayba; Morris, Suzanne

2016-09-01

Research has identified the core skills that predict success during primary school in reading and arithmetic, and this knowledge increasingly informs teaching. However, there has been no comparable work that pinpoints the core skills that underlie success in science. The present paper attempts to redress this by examining candidate skills and considering what is known about the way in which they emerge, how they relate to each other and to other abilities, how they change with age, and how their growth may vary between topic areas. There is growing evidence that early-emerging tacit awareness of causal associations is initially separated from language-based causal knowledge, which is acquired in part from everyday conversation and shows inaccuracies not evident in tacit knowledge. Mapping of descriptive and explanatory language onto causal awareness appears therefore to be a key development, which promotes unified conceptual and procedural understanding. This account suggests that the core components of initial science learning are (1) accurate observation, (2) the ability to extract and reason explicitly about causal connections, and (3) knowledge of mechanisms that explain these connections. Observational ability is educationally inaccessible until integrated with verbal description and explanation, for instance, via collaborative group work tasks that require explicit reasoning with respect to joint observations. Descriptive ability and explanatory ability are further promoted by managed exposure to scientific vocabulary and use of scientific language. Scientific reasoning and hypothesis testing are later acquisitions that depend on this integration of systems and improved executive control. © 2016 The British Psychological Society.

Effects of core retrieval, handling, and preservation on hydrate-bearing samples

NASA Astrophysics Data System (ADS)

Kneafsey, T. J.; Lu, H.; Winters, W. J.; Hunter, R. B.

2009-12-01

Recovery, preservation, storage, and transport of samples containing natural gas hydrate cause changes in the stress conditions, temperature, pressure, and hydrate saturation of samples. Sample handling at the ground surface and sample preservation, either by freezing in liquid nitrogen (LN) or repressurization using methane, provides additional time and driving forces for sample alteration. The extent to which these disturbances alter the properties of the hydrate bearing sediments (HBS) depend on specific sample handling techniques, as well as on the sample itself. HBS recovered during India’s National Gas Hydrate Program (NGHP) Expedition 01 and the 2007 BP Exploration Alaska - Department of Energy - U.S. Geological Survey (BP-DOE-USGS) Mount Elbert (ME) gas hydrate well on the Alaskan North Slope provide comparisons of sample alterations induced by multiple handling techniques. HBS samples from the NGHP and the ME projects were examined using x-ray computed tomography. Mount Elbert sand samples initially preserved in LN have non-uniform short “crack-like” low-density zones in the center that probably do not extend to the outside perimeter. Samples initially preserved by repressurization show fewer “crack-like” features and higher densities. Two samples were analyzed in detail by Lu and coworkers showing reduced hydrate saturations approaching the outer surface, while substantial hydrate remained in the central region. Non-pressure cored NGHP samples show relatively large altered regions approaching the core surface, while pressure-cored-liquid-nitrogen preserved samples have much less alteration.

Measuring and predicting reservoir heterogeneity in complex deposystems. Annual report, September 20, 1990--September 20, 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donaldson, A.; Shumaker, R.; Laughrey, C.

1992-08-01

The Lower Mississippian Big Injun sandstone, a major oil producer in the western half of West Virginia, consists of several sandstones that overstep each west. Examination of cores and thin sections has led to preliminary interpretations of depositional environments for the Big Injun. These include distributary-mouth bars with associated distal, bar crest and back bar environments in a marine-deltaic system; and channel, point bar and chute environments in a fluvial system. Overall, the Big Injun is a medium-grained sublitharenite in which initially high porosity has been modified by compaction and diagenesis. Chlorite grain coatings helped to preserve original porosity, whereasmore » illite promoted pressure solution during compaction, resulting in a loss of porosity. Diagenetic effects within specific environments are being evaluated to determine if environmental interpretations can be used to predict porosity preservation. Core plugs taken from cores in Granny Creek field were analyzed for porosity and horizontal and vertical permeability. Directional permeability was negligible, but permeability does correlate with depth. Changes in permeability with depth can be related to subdivisions of the Big Injun determined from density logs. Permeability also correlated with porosity, but porosity values derived from both cores and logs show no significant correlation trend at present. A layered reservoir model is being developed to evaluate the effect of these vertical heterogeneities. Initial attempts to characterize the heterogeneity of the Big Injun reservoir in Granny Creek field used a number of direct and indirect methods.« less

Measuring and predicting reservoir heterogeneity in complex deposystems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donaldson, A.; Shumaker, R.; Laughrey, C.

1992-08-01

The Lower Mississippian Big Injun sandstone, a major oil producer in the western half of West Virginia, consists of several sandstones that overstep each west. Examination of cores and thin sections has led to preliminary interpretations of depositional environments for the Big Injun. These include distributary-mouth bars with associated distal, bar crest and back bar environments in a marine-deltaic system; and channel, point bar and chute environments in a fluvial system. Overall, the Big Injun is a medium-grained sublitharenite in which initially high porosity has been modified by compaction and diagenesis. Chlorite grain coatings helped to preserve original porosity, whereasmore » illite promoted pressure solution during compaction, resulting in a loss of porosity. Diagenetic effects within specific environments are being evaluated to determine if environmental interpretations can be used to predict porosity preservation. Core plugs taken from cores in Granny Creek field were analyzed for porosity and horizontal and vertical permeability. Directional permeability was negligible, but permeability does correlate with depth. Changes in permeability with depth can be related to subdivisions of the Big Injun determined from density logs. Permeability also correlated with porosity, but porosity values derived from both cores and logs show no significant correlation trend at present. A layered reservoir model is being developed to evaluate the effect of these vertical heterogeneities. Initial attempts to characterize the heterogeneity of the Big Injun reservoir in Granny Creek field used a number of direct and indirect methods.« less

FAILURE OF A NEUTRINO-DRIVEN EXPLOSION AFTER CORE-COLLAPSE MAY LEAD TO A THERMONUCLEAR SUPERNOVA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kushnir, Doron; Katz, Boaz, E-mail: kushnir@ias.edu

We demonstrate that ∼10 s after the core-collapse of a massive star, a thermonuclear explosion of the outer shells is possible for some (tuned) initial density and composition profiles, assuming that the neutrinos failed to explode the star. The explosion may lead to a successful supernova, as first suggested by Burbidge et al. We perform a series of one-dimensional (1D) calculations of collapsing massive stars with simplified initial density profiles (similar to the results of stellar evolution calculations) and various compositions (not similar to 1D stellar evolution calculations). We assume that the neutrinos escaped with a negligible effect on themore » outer layers, which inevitably collapse. As the shells collapse, they compress and heat up adiabatically, enhancing the rate of thermonuclear burning. In some cases, where significant shells of mixed helium and oxygen are present with pre-collapsed burning times of ≲100 s (≈10 times the free-fall time), a thermonuclear detonation wave is ignited, which unbinds the outer layers of the star, leading to a supernova. The energy released is small, ≲10{sup 50} erg, and negligible amounts of synthesized material (including {sup 56}Ni) are ejected, implying that these 1D simulations are unlikely to represent typical core-collapse supernovae. However, they do serve as a proof of concept that the core-collapse-induced thermonuclear explosions are possible, and more realistic two-dimensional and three-dimensional simulations are within current computational capabilities.« less

Core strength training using a combination of home exercises and a dynamic sling system for the management of low back pain in pre-professional ballet dancers: a case series.

PubMed

Kline, Jessica Beckmann; Krauss, John R; Maher, Sara F; Qu, Xianggui

2013-01-01

Estimates of low back pain prevalence in USA ballet dancers range from 8% to 23%. Lumbar stabilization and extensor muscle training has been shown to act as a hypoalgesic for low back pain. Timing and coordination of multifidi and transverse abdominis muscles are recognized as important factors for spinal stabilization. The purpose of this study was to explore the effects of training methods using home exercises and a dynamic sling system on core strength, disability, and low back pain in pre-professional ballet dancers. Five participants were randomly assigned to start a traditional unsupervised lumbar stabilization home exercise program (HEP) or supervised dynamic sling training to strengthen the core and lower extremities. Measurements were taken at baseline and at weeks 3 and 6 for disability using the patient specific functional scale (PSFS), pain using the Numerical Pain Rating System (NPRS), core strength and endurance using timed plank, side-plank, and bridge positions, and sciatic nerve irritability using the straight leg raise (SLR). Data were analyzed using descriptive statistics. From initial to final measurements, all participants demonstrated an improvement in strength and SLR range, and those with initial pain and disability reported relief of symptoms. These results suggest that dynamic sling training and a HEP may help to increase strength, decrease pain, and improve function in dancers without aggravating sciatic nerve irritation.

Effects of basin-forming impacts on the thermal evolution and magnetic field of Mars

NASA Astrophysics Data System (ADS)

Roberts, J. H.; Arkani-Hamed, J.

2017-11-01

The youngest of the giant impact basins on Mars are either weakly magnetized or completely demagnetized, indicating that a global magnetic field was not present at the time those basins formed. Eight basins are sufficiently large that the impact heating associated with their formation could have penetrated below the core-mantle boundary (CMB). Here we investigate the thermal evolution of the martian interior and the fate of the global magnetic field using 3D mantle convection models coupled to a parameterized 1D core thermal evolution model. We find that the survival of the impact-induced temperature anomalies in the upper mantle is strongly controlled by the mantle viscosity. Impact heating from subsequent impacts can accumulate in stiffer mantles faster than it can be advected away, resulting in a thermal blanket that insulates an entire hemisphere. The impact heating in the core will halt dynamo activity, at least temporarily. If the mantle is initially cold, and the core initially superheated, dynamo activity may resume as quickly as a few Myr after each impact. However unless the lower mantle has either a low viscosity or a high thermal conductivity, this restored dynamo will last for only a few hundred Myr after the end of the sequence of impacts. Thus, we find that the longevity of the magnetic field is more strongly controlled by the lower mantle properties and relatively insensitive to the impact-induced temperature anomalies in the upper mantle.

Body and brain temperature coupling: the critical role of cerebral blood flow

PubMed Central

Ackerman, Joseph J. H.; Yablonskiy, Dmitriy A.

2010-01-01

Direct measurements of deep-brain and body-core temperature were performed on rats to determine the influence of cerebral blood flow (CBF) on brain temperature regulation under static and dynamic conditions. Static changes of CBF were achieved using different anesthetics (chloral hydrate, CH; α-chloralose, αCS; and isoflurane, IF) with αCS causing larger decreases in CBF than CH and IF; dynamic changes were achieved by inducing transient hypercapnia (5% CO2 in 40% O2 and 55% N2). Initial deep-brain/body-core temperature differentials were anesthetic-type dependent with the largest differential observed with rats under αCS anesthesia (ca. 2°C). Hypercapnia induction raised rat brain temperature under all three anesthesia regimes, but by different anesthetic-dependent amounts correlated with the initial differentials—αCS anesthesia resulted in the largest brain temperature increase (0.32 ± 0.08°C), while CH and IF anesthesia lead to smaller increases (0.12 ± 0.03 and 0.16 ± 0.05°C, respectively). The characteristic temperature transition time for the hypercapnia-induced temperature increase was 2–3 min under CH and IF anesthesia and ~4 min under αCS anesthesia. We conclude that both, the deep-brain/body-core temperature differential and the characteristic temperature transition time correlate with CBF: a lower CBF promotes higher deep-brain/body-core temperature differentials and, upon hypercapnia challenge, longer characteristic transition times to increased temperatures. PMID:19277681

Body and brain temperature coupling: the critical role of cerebral blood flow.

PubMed

Zhu, Mingming; Ackerman, Joseph J H; Yablonskiy, Dmitriy A

2009-08-01

Direct measurements of deep-brain and body-core temperature were performed on rats to determine the influence of cerebral blood flow (CBF) on brain temperature regulation under static and dynamic conditions. Static changes of CBF were achieved using different anesthetics (chloral hydrate, CH; alpha-chloralose, alphaCS; and isoflurane, IF) with alphaCS causing larger decreases in CBF than CH and IF; dynamic changes were achieved by inducing transient hypercapnia (5% CO(2) in 40% O(2) and 55% N(2)). Initial deep-brain/body-core temperature differentials were anesthetic-type dependent with the largest differential observed with rats under alphaCS anesthesia (ca. 2 degrees C). Hypercapnia induction raised rat brain temperature under all three anesthesia regimes, but by different anesthetic-dependent amounts correlated with the initial differentials--alphaCS anesthesia resulted in the largest brain temperature increase (0.32 +/- 0.08 degrees C), while CH and IF anesthesia lead to smaller increases (0.12 +/- 0.03 and 0.16 +/- 0.05 degrees C, respectively). The characteristic temperature transition time for the hypercapnia-induced temperature increase was 2-3 min under CH and IF anesthesia and approximately 4 min under alphaCS anesthesia. We conclude that both, the deep-brain/body-core temperature differential and the characteristic temperature transition time correlate with CBF: a lower CBF promotes higher deep-brain/body-core temperature differentials and, upon hypercapnia challenge, longer characteristic transition times to increased temperatures.

Tree Islands of the Florida Everglades - A Disappearing Resource

USGS Publications Warehouse

,

2003-01-01

Until recently, the timing and cause of tree island formation have been poorly understood, with estimates of initial tree-island development as early as thousands of years ago to as recently as the last few decades. To increase our knowledge about the origins of these features, sediment cores were collected on and around tree islands. These cores were dated using radioisotopic techniques, including carbon-14 dating, which provides reliable dates from ~40,000 to ~300 years ago, and lead-210 dating, which provides age models for the last century. These age models were paired with vegetational reconstruction based on pollen analysis from cores to identify the timing of tree-island formation and assess past tree-island response to hydrologic changes in the 20th century.

Kin28 regulates the transient association of Mediator with core promoters.

PubMed

Jeronimo, Célia; Robert, François

2014-05-01

Mediator is an essential, broadly used eukaryotic transcriptional coactivator. How and what Mediator communicates from activators to RNA polymerase II (RNAPII) remains an open question. Here we performed genome-wide location profiling of Saccharomyces cerevisiae Mediator subunits. Mediator is not found at core promoters but rather occupies the upstream activating sequence, upstream of the pre-initiation complex. In the absence of Kin28 (CDK7) kinase activity or in cells in which the RNAPII C-terminal domain is mutated to replace Ser5 with alanine, however, Mediator accumulates at core promoters together with RNAPII. We propose that Mediator is released quickly from promoters after phosphorylation of Ser5 by Kin28 (CDK7), which also allows for RNAPII to escape from the promoter.

NUCLEAR REACTOR CONTROL SYSTEM

DOEpatents

Howard, D.F.; Motta, E.E.

1961-06-27

A method for controlling the excess reactivity in a nuclear reactor throughout the core life while maintaining the neutron flux distribution at the desired level is described. The control unit embodies a container having two electrodes of different surface area immersed in an electrolytic solution of a good neutron sbsorbing metal ion such as boron, gadolinium, or cadmium. Initially, the neutron absorber is plated on the larger electrode to control the greater neutron flux of a freshly refueled core. As the fuel burns up, the excess reactivity decreases and the neutron absorber is then plated onto the smaller electrode so that the number of neutrons absorbed also decreases. The excess reactivity in the core may thus be maintained without the introduction of serious perturbations in the neutron flux distributibn.

A First Look at Higher Performing High Schools: School Qualities that Educators Believe Contribute Most to College and Career Readiness

ERIC Educational Resources Information Center

ACT, Inc., 2012

2012-01-01

The Common Core State Standards Initiative represents one of the most significant reforms to US education in recent history. As of June 2012, 45 states and the District of Columbia have adopted the Standards. ACT is pleased to have played a leading role in the development of the Standards. Not only did the initiative draw on its longitudinal…

Ready for the Future: Assessing the Collaborative Capacity of State Emergency Management Agencies

DTIC Science & Technology

2013-03-01

Management and Budget, Paperwork Reduction Project (0704-0188) Washington DC 20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE March 2013...Preparedness) SEOC State Emergency Operations Center xiv SFI Strategic Foresight Initiative SPSS Statistical Package for the Social Sciences UASI... management discipline and to define the core capabilities to meet those needs. The Strategic Foresight Initiative (SFI) resulted in a vision document

Functional Mission Analysis (FMA) for the Air Force Cyber Squadron Initiative (CS I)

DTIC Science & Technology

2017-03-17

Analysis for the Air Force Cyber Squadron Initiative DESIGN PROJECT CONDUCTED 13 FEB – 17 FEB 17 Produced with input from numerous units...Success The Air Force’s base-level Communications Squadrons are engaged in a cultural and technological transformation through the Cyber Squadron...sharpening their focus to include active cyber defense and mission assurance as core competencies to enable operational advantages and out-maneuver our

Necrosome core machinery: MLKL.

PubMed

Zhang, Jing; Yang, Yu; He, Wenyan; Sun, Liming

2016-06-01

In the study of regulated cell death, the rapidly expanding field of regulated necrosis, in particular necroptosis, has been drawing much attention. The signaling of necroptosis represents a sophisticated form of a death pathway. Anti-caspase mechanisms (e.g., using inhibitors of caspases, or genetic ablation of caspase-8) switch cell fate from apoptosis to necroptosis. The initial extracellular death signals regulate RIP1 and RIP3 kinase activation. The RIP3-associated death complex assembly is necessary and sufficient to initiate necroptosis. MLKL was initially identified as an essential mediator of RIP1/RIP3 kinase-initiated necroptosis. Recent studies on the signal transduction using chemical tools and biomarkers support the idea that MLKL is able to make more functional sense for the core machinery of the necroptosis death complex, called the necrosome, to connect to the necroptosis execution. The experimental data available now have pointed that the activated MLKL forms membrane-disrupting pores causing membrane leakage, which extends the prototypical concept of morphological and biochemical events following necroptosis happening in vivo. The key role of MLKL in necroptosis signaling thus sheds light on the logic underlying this unique "membrane-explosive" cell death pathway. In this review, we provide the general concepts and strategies that underlie signal transduction of this form of cell death, and then focus specifically on the role of MLKL in necroptosis.

ON THE COAGULATION AND SIZE DISTRIBUTION OF PRESSURE CONFINED CORES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang Xu; Zhou Tingtao; Lin, D. N. C., E-mail: xuhuang@princeton.edu

2013-05-20

Observations of the Pipe Nebula have led to the discovery of dense starless cores. The mass of most cores is too small for their self-gravity to hold them together. Instead, they are thought to be pressure confined. The observed dense cores' mass function (CMF) matches well with the initial mass function of stars in young clusters. Similar CMFs are observed in other star forming regions such as the Aquila Nebula, albeit with some dispersion. The shape of these CMF provides important clues to the competing physical processes which lead to star formation and its feedback on the interstellar media. Inmore » this paper, we investigate the dynamical origin of the mass function of starless cores which are confined by a warm, less dense medium. In order to follow the evolution of the CMF, we construct a numerical method to consider the coagulation between the cold cores and their ablation due to Kelvin-Helmholtz instability induced by their relative motion through the warm medium. We are able to reproduce the observed CMF among the starless cores in the Pipe Nebula. Our results indicate that in environment similar to the Pipe Nebula: (1) before the onset of their gravitational collapse, the mass distribution of the progenitor cores is similar to that of the young stars, (2) the observed CMF is a robust consequence of dynamical equilibrium between the coagulation and ablation of cores, and (3) a break in the slope of the CMF is due to the enhancement of collisional cross section and suppression of ablation for cores with masses larger than the cores' Bonnor-Ebert mass.« less

Hepatitis C virus core protein targets 4E-BP1 expression and phosphorylation and potentiates Myc-induced liver carcinogenesis in transgenic mice.

PubMed

Abdallah, Cosette; Lejamtel, Charlène; Benzoubir, Nassima; Battaglia, Serena; Sidahmed-Adrar, Nazha; Desterke, Christophe; Lemasson, Matthieu; Rosenberg, Arielle R; Samuel, Didier; Bréchot, Christian; Pflieger, Delphine; Le Naour, François; Bourgeade, Marie-Françoise

2017-08-22

Hepatitis C virus (HCV) is a leading cause of liver diseases including the development of hepatocellular carcinoma (HCC). Particularly, core protein has been involved in HCV-related liver pathologies. However, the impact of HCV core on signaling pathways supporting the genesis of HCC remains largely elusive. To decipher the host cell signaling pathways involved in the oncogenic potential of HCV core, a global quantitative phosphoproteomic approach was carried out. This study shed light on novel differentially phosphorylated proteins, in particular several components involved in translation. Among the eukaryotic initiation factors that govern the translational machinery, 4E-BP1 represents a master regulator of protein synthesis that is associated with the development and progression of cancers due to its ability to increase protein expression of oncogenic pathways. Enhanced levels of 4E-BP1 in non-modified and phosphorylated forms were validated in human hepatoma cells and in mouse primary hepatocytes expressing HCV core, in the livers of HCV core transgenic mice as well as in HCV-infected human primary hepatocytes. The contribution of HCV core in carcinogenesis and the status of 4E-BP1 expression and phosphorylation were studied in HCV core/Myc double transgenic mice. HCV core increased the levels of 4E-BP1 expression and phosphorylation and significantly accelerated the onset of Myc-induced tumorigenesis in these double transgenic mice. These results reveal a novel function of HCV core in liver carcinogenesis potentiation. They position 4E-BP1 as a tumor-specific target of HCV core and support the involvement of the 4E-BP1/eIF4E axis in hepatocarcinogenesis.

Statistical errors and systematic biases in the calibration of the convective core overshooting with eclipsing binaries. A case study: TZ Fornacis

NASA Astrophysics Data System (ADS)

Valle, G.; Dell'Omodarme, M.; Prada Moroni, P. G.; Degl'Innocenti, S.

2017-04-01

Context. Recently published work has made high-precision fundamental parameters available for the binary system TZ Fornacis, making it an ideal target for the calibration of stellar models. Aims: Relying on these observations, we attempt to constrain the initial helium abundance, the age and the efficiency of the convective core overshooting. Our main aim is in pointing out the biases in the results due to not accounting for some sources of uncertainty. Methods: We adopt the SCEPtER pipeline, a maximum likelihood technique based on fine grids of stellar models computed for various values of metallicity, initial helium abundance and overshooting efficiency by means of two independent stellar evolutionary codes, namely FRANEC and MESA. Results: Beside the degeneracy between the estimated age and overshooting efficiency, we found the existence of multiple independent groups of solutions. The best one suggests a system of age 1.10 ± 0.07 Gyr composed of a primary star in the central helium burning stage and a secondary in the sub-giant branch (SGB). The resulting initial helium abundance is consistent with a helium-to-metal enrichment ratio of ΔY/ ΔZ = 1; the core overshooting parameter is β = 0.15 ± 0.01 for FRANEC and fov = 0.013 ± 0.001 for MESA. The second class of solutions, characterised by a worse goodness-of-fit, still suggest a primary star in the central helium-burning stage but a secondary in the overall contraction phase, at the end of the main sequence (MS). In this case, the FRANEC grid provides an age of Gyr and a core overshooting parameter , while the MESA grid gives 1.23 ± 0.03 Gyr and fov = 0.025 ± 0.003. We analyse the impact on the results of a larger, but typical, mass uncertainty and of neglecting the uncertainty in the initial helium content of the system. We show that very precise mass determinations with uncertainty of a few thousandths of solar mass are required to obtain reliable determinations of stellar parameters, as mass errors larger than approximately 1% lead to estimates that are not only less precise but also biased. Moreover, we show that a fit obtained with a grid of models computed at a fixed ΔY/ ΔZ - thus neglecting the current uncertainty in the initial helium content of the system - can provide severely biased age and overshooting estimates. The possibility of independent overshooting efficiencies for the two stars of the system is also explored. Conclusions: The present analysis confirms that to constrain the core overshooting parameter by means of binary systems is a very difficult task that requires an observational precision still rarely achieved and a robust statistical treatment of the error sources.

The Colorado Plateau Coring Project: A Continuous Cored Non-Marine Record of Early Mesozoic Environmental and Biotic Change

NASA Astrophysics Data System (ADS)

Irmis, Randall; Olsen, Paul; Geissman, John; Gehrels, George; Kent, Dennis; Mundil, Roland; Rasmussen, Cornelia; Giesler, Dominique; Schaller, Morgan; Kürschner, Wolfram; Parker, William; Buhedma, Hesham

2017-04-01

The early Mesozoic is a critical time in earth history that saw the origin of modern ecosystems set against the back-drop of mass extinction and sudden climate events in a greenhouse world. Non-marine sedimentary strata in western North America preserve a rich archive of low latitude terrestrial ecosystem and environmental change during this time. Unfortunately, frequent lateral facies changes, discontinuous outcrops, and a lack of robust geochronologic constraints make lithostratigraphic and chronostratigraphic correlation difficult, and thus prevent full integration of these paleoenvironmental and paleontologic data into a regional and global context. The Colorado Plateau Coring Project (CPCP) seeks to remedy this situation by recovering a continuous cored record of early Mesozoic sedimentary rocks from the Colorado Plateau of the western United States. CPCP Phase 1 was initiated in 2013, with NSF- and ICDP-funded drilling of Triassic units in Petrified Forest National Park, northern Arizona, U.S.A. This phase recovered a 520 m core (1A) from the northern part of the park, and a 240 m core (2B) from the southern end of the park, comprising the entire Lower-Middle Triassic Moenkopi Formation, and most of the Upper Triassic Chinle Formation. Since the conclusion of drilling, the cores have been CT scanned at the University of Texas - Austin, and split, imaged, and scanned (e.g., XRF, gamma, and magnetic susceptibility) at the University of Minnesota LacCore facility. Subsequently, at the Rutgers University Core Repository, core 1A was comprehensively sampled for paleomagnetism, zircon geochronology, petrography, palynology, and soil carbonate stable isotopes. LA-ICPMS U-Pb zircon analyses are largely complete, and CA-TIMS U-Pb zircon, paleomagnetic, petrographic, and stable isotope analyses are on-going. Initial results reveal numerous horizons with a high proportion of Late Triassic-aged primary volcanic zircons, the age of which appears to be a close approximation of their host rock's depositional age, along with significant populations of early Paleozoic and Proterozoic zircons which will be used to identify provenance. Thermal demagnetization of paleomagnetic samples show that most Moenkopi and some fine-grained Chinle lithologies preserve a primary magnetization, and thus will allow the construction of a robust magnetostratigraphy for portions of the Triassic section. Soil carbonates are abundant throughout the cored section. All data will be integrated to construct an exportable chronostratigraphic framework that will allow us to test a number of major questions with global implications for understanding the early Mesozoic world, including: 1) do independent U-Pb ages support the accuracy of the Newark astronomically-calibrated geomagnetic polarity timescale? 2) is the mid-Late Triassic biotic turnover observable in the western US coincident with the Manicouagan bolide impact? and 3) are cyclical climate variations apparent in the cored record, and do they reflect variations in atmospheric CO2?

Coronal Heating by Magnetic Explosions

NASA Technical Reports Server (NTRS)

Moore, Ronald L.; Falconer, D. A.; Porter, Jason G.; Suess, Steven T.

1998-01-01

We build a case for the persistent strong coronal heating in active regions and the pervasive quasi-steady heating of the corona in quiet regions and coronal holes being driven in basically the same way as the intense transient heating in solar flares: by explosions of sheared magnetic fields in the cores of initially closed bipoles. We begin by summarizing the observational case for exploding sheared core fields being the drivers of a wide variety of flare events, with and without coronal mass ejections. We conclude that the arrangement of an event's flare heating, whether there is a coronal mass ejection, and the time and place of the ejection relative to the flare heating are all largely determined by four elements of the form and action the magnetic field: (1) the arrangement of the impacted, interacting bipoles participating in the event, (2) which of these bipoles are active (have sheared core fields that explode) and which are passive (are heated by injection from impacted active bipoles), (3) which core field explodes first, and (4) which core-field explosions are confined within the closed field of their bipoles and which ejectively open their bipoles.

Multi-tiered S-SOA, Parameter-Driven New Islamic Syariah Products of Holistic Islamic Banking System (HiCORE): Virtual Banking Environment

NASA Astrophysics Data System (ADS)

Halimah, B. Z.; Azlina, A.; Sembok, T. M.; Sufian, I.; Sharul Azman, M. N.; Azuraliza, A. B.; Zulaiha, A. O.; Nazlia, O.; Salwani, A.; Sanep, A.; Hailani, M. T.; Zaher, M. Z.; Azizah, J.; Nor Faezah, M. Y.; Choo, W. O.; Abdullah, Chew; Sopian, B.

The Holistic Islamic Banking System (HiCORE), a banking system suitable for virtual banking environment, created based on universityindustry collaboration initiative between Universiti Kebangsaan Malaysia (UKM) and Fuziq Software Sdn Bhd. HiCORE was modeled on a multitiered Simple - Services Oriented Architecture (S-SOA), using the parameterbased semantic approach. HiCORE's existence is timely as the financial world is looking for a new approach to creating banking and financial products that are interest free or based on the Islamic Syariah principles and jurisprudence. An interest free banking system has currently caught the interest of bankers and financiers all over the world. HiCORE's Parameter-based module houses the Customer-information file (CIF), Deposit and Financing components. The Parameter based module represents the third tier of the multi-tiered Simple SOA approach. This paper highlights the multi-tiered parameter- driven approach to the creation of new Islamiic products based on the 'dalil' (Quran), 'syarat' (rules) and 'rukun' (procedures) as required by the syariah principles and jurisprudence reflected by the semantic ontology embedded in the parameter module of the system.

A core syllabus for the teaching of neuroanatomy to medical students.

PubMed

Moxham, Bernard; McHanwell, Stephen; Plaisant, Odile; Pais, Diogo

2015-09-01

There is increasingly a call for clinical relevance in the teaching of biomedical sciences within all health care courses. However, this presupposes that there is a clear understanding of what can be considered core material within the curricula. To date, the anatomical sciences have been relatively poorly served by the development of core syllabuses, particularly for specialized core syllabuses such as neuroanatomy. One of the aims of the International Federation of Associations of Anatomists (IFAA) and of the European Federation for Experimental Morphology (EFEM) is to formulate, on an international scale, core syllabuses for all branches of the anatomical sciences using Delphi Panels consisting of anatomists, scientists, and clinicians to initially evaluate syllabus content. In this article, the findings of a Delphi Panel for neuroanatomy are provided. These findings will subsequently be published on the IFAA website to enable anatomical (and other cognate learned) societies and individual anatomists, clinicians, and students to freely comment upon, and elaborate and amend, the syllabuses. The aim is to set internationally recognized standards and thus to provide guidelines concerning neuroanatomical knowledge when engaged in course development. © 2015 Wiley Periodicals, Inc.

Training infection control and hospital hygiene professionals in Europe, 2010: agreed core competencies among 33 European countries.

PubMed

Brusaferro, S; Cookson, B; Kalenic, S; Cooper, T; Fabry, J; Gallagher, R; Hartemann, P; Mannerquist, K; Popp, W; Privitera, G; Ruef, C; Viale, P; Coiz, F; Fabbro, E; Suetens, C; Varela Santos, C

2014-12-11

The harmonisation of training programmes for infection control and hospital hygiene (IC/HH) professionals in Europe is a requirement of the Council recommendation on patient safety. The European Centre for Disease Prevention and Control commissioned the 'Training Infection Control in Europe' project to develop a consensus on core competencies for IC/HH professionals in the European Union (EU). Core competencies were drafted on the basis of the Improving Patient Safety in Europe (IPSE) project's core curriculum (CC), evaluated by questionnaire and approved by National Representatives (NRs) for IC/HH training. NRs also re-assessed the status of IC/HH training in European countries in 2010 in comparison with the situation before the IPSE CC in 2006. The IPSE CC had been used to develop or update 28 of 51 IC/HH courses. Only 10 of 33 countries offered training and qualification for IC/HH doctors and nurses. The proposed core competencies are structured in four areas and 16 professional tasks at junior and senior level. They form a reference for standardisation of IC/HH professional competencies and support recognition of training initiatives.

Development of the RANCOR Rotary-Percussive Coring System for Mars Sample Return

NASA Technical Reports Server (NTRS)

Paulsen, Gale; Indyk, Stephen; Zacny, Kris

2014-01-01

A RANCOR drill was designed to fit a Mars Exploration Rover (MER) class vehicle. The low mass of 3 kg was achieved by using the same actuator for three functions: rotation, percussions, and core break-off. Initial testing of the drill exposed an unexpected behavior of an off-the-shelf sprag clutch used to couple and decouple rotary-percussive function from the core break off function. Failure of the sprag was due to the vibration induced during percussive drilling. The sprag clutch would back drive in conditions where it was expected to hold position. Although this did not affect the performance of the drill, it nevertheless reduced the quality of the cores produced. Ultimately, the sprag clutch was replaced with a custom ratchet system that allowed for some angular displacement without advancing in either direction. Replacing the sprag with the ratchet improved the collected core quality. Also, premature failure of a 300-series stainless steel percussion spring was observed. The 300-series percussion spring was ultimately replaced with a music wire spring based on performances of previously designed rotary-percussive drill systems.

Detectability and Uncertainties of the Supernova Relic Neutrino Background

NASA Astrophysics Data System (ADS)

Nakazato, Ken'ichiro; Mochida, Eri; Niino, Yuu; Suzuki, Hideyuki

The spectrum of the supernova relic neutrino (SRN) background from past stellar core collapses is calculated and its detectability at SK-Gd (Super-Kamiokande experiment with gadolinium-loaded water) is investigated. Several uncertainties on the flux of SRNs are considered. The core collapse rate at each redshift depends on the cosmic star formation rate, initial mass function and mass range of progenitors that end with a core collapse. The shock revival time is introduced as a parameter that should depend on the still unknown explosion mechanism of core collapse supernovae. Furthermore, since the neutrino luminosity of black-hole-forming failed supernovae is higher than that of ordinary supernovae, their contribution to SRNs is quantitatively estimated. Assuming the mass and metallicity ranges of their progenitors, the redshift dependence of the black hole formation rate is considered on the basis of the metallicity evolution of galaxies. As a result, it is found that the expected event rate of SRNs is comparable with other backgrounds at SK-Gd. Therefore, the required observation time to detect SRNs at SK-Gd depends strongly on the core collapse rate and it is 10-300 years.

Merging of Kirkendall Growth and Ostwald Ripening: CuO@MnO2 Core-shell Architectures for Asymmetric Supercapacitors

PubMed Central

Huang, Ming; Zhang, Yuxin; Li, Fei; Wang, Zhongchang; Alamusi; Hu, Ning; Wen, Zhiyu; Liu, Qing

2014-01-01

Fabricating hierarchical core-shell nanostructures is currently the subject of intensive research in the electrochemical field owing to the hopes it raises for making efficient electrodes for high-performance supercapacitors. Here, we develop a simple and cost-effective approach to prepare CuO@MnO2 core-shell nanostructures without any surfactants and report their applications as electrodes for supercapacitors. An asymmetric supercapacitor with CuO@MnO2 core-shell nanostructure as the positive electrode and activated microwave exfoliated graphite oxide (MEGO) as the negative electrode yields an energy density of 22.1 Wh kg−1 and a maximum power density of 85.6 kW kg−1; the device shows a long-term cycling stability which retains 101.5% of its initial capacitance even after 10000 cycles. Such a facile strategy to fabricate the hierarchical CuO@MnO2 core-shell nanostructure with significantly improved functionalities opens up a novel avenue to design electrode materials on demand for high-performance supercapacitor applications. PMID:24682149

Hierarchically mesoporous CuO/carbon nanofiber coaxial shell-core nanowires for lithium ion batteries

PubMed Central

Park, Seok-Hwan; Lee, Wan-Jin

2015-01-01

Hierarchically mesoporous CuO/carbon nanofiber coaxial shell-core nanowires (CuO/CNF) as anodes for lithium ion batteries were prepared by coating the Cu2(NO3)(OH)3 on the surface of conductive and elastic CNF via electrophoretic deposition (EPD), followed by thermal treatment in air. The CuO shell stacked with nanoparticles grows radially toward the CNF core, which forms hierarchically mesoporous three-dimensional (3D) coaxial shell-core structure with abundant inner spaces in nanoparticle-stacked CuO shell. The CuO shells with abundant inner spaces on the surface of CNF and high conductivity of 1D CNF increase mainly electrochemical rate capability. The CNF core with elasticity plays an important role in strongly suppressing radial volume expansion by inelastic CuO shell by offering the buffering effect. The CuO/CNF nanowires deliver an initial capacity of 1150 mAh g−1 at 100 mA g−1 and maintain a high reversible capacity of 772 mAh g−1 without showing obvious decay after 50 cycles. PMID:25944615

Report: Review of Region 5 Laboratory Operations

EPA Pesticide Factsheets

Report #2000-P-3, Jan 1, 2000. In September 1998, the Region 5 Quality Assurance Core initiated a Management Systems Review of the CRL to determine whether the lab’s quality management system was operating as designed.

Phenomenological investigation of despair in depression.

PubMed

Bürgy, Martin

2008-01-01

In current psychopathological literature, the concept of despair is almost redundant. At most, the term is applied in a behavioral biological context as a synonym for helplessness and hopelessness. In light of the fact that the subjective experience of despair is neglected, the present paper adopts a phenomenological approach. The selection and hermeneutic investigation of philosophical concepts serve as tools for an initial delineation of the core structure of despair. On the basis of a growing deviation between desire and reality, target and actual status, an alternating development is initiated which increasingly constricts and leads to hopelessness and suicide. This phenomenological core structure is identified from a number of integral characteristics of depression and further developed. Despair, thus, becomes a psychopathological key term through which access can be gained to the subjective experience of the depressive individual and which can provide the basis for promoting understanding and communication as well as developing successful therapeutic interventions.

Tornado wind-loading requirements based on risk assessment techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deobald, T.L.; Coles, G.A.; Smith, G.L.

Regulations require that nuclear power plants be protected from tornado winds. If struck by a tornado, a plant must be capable of safely shutting down and removing decay heat. Probabilistic techniques are used to show that risk to the public from the US Department of Energy (DOE) SP-100 reactor is acceptable without tornado hardening parts of the secondary system. Relaxed requirements for design wind loadings will result in significant cost savings. To demonstrate an acceptable level of risk, this document examines tornado-initiated accidents. The two tornado-initiated accidents examined in detail are loss of cooling resulting in core damage and lossmore » of secondary system boundary integrity leading to sodium release. Loss of core cooling is analyzed using fault/event tree models. Loss of secondary system boundary integrity is analyzed by comparing the consequences to acceptance criteria for the release of radioactive material or alkali metal aerosol. 4 refs., 4 figs.« less

Experiments with a Parallel Multi-Objective Evolutionary Algorithm for Scheduling

NASA Technical Reports Server (NTRS)

Brown, Matthew; Johnston, Mark D.

2013-01-01

Evolutionary multi-objective algorithms have great potential for scheduling in those situations where tradeoffs among competing objectives represent a key requirement. One challenge, however, is runtime performance, as a consequence of evolving not just a single schedule, but an entire population, while attempting to sample the Pareto frontier as accurately and uniformly as possible. The growing availability of multi-core processors in end user workstations, and even laptops, has raised the question of the extent to which such hardware can be used to speed up evolutionary algorithms. In this paper we report on early experiments in parallelizing a Generalized Differential Evolution (GDE) algorithm for scheduling long-range activities on NASA's Deep Space Network. Initial results show that significant speedups can be achieved, but that performance does not necessarily improve as more cores are utilized. We describe our preliminary results and some initial suggestions from parallelizing the GDE algorithm. Directions for future work are outlined.

Influence of Initial Vorticity Distribution on Axisymmetric Vortex Breakdown and Reconnection

NASA Technical Reports Server (NTRS)

Young, Larry A.

2007-01-01

An analytical treatment has been developed to study some of the axisymmetric vortex breakdown and reconnection fluid dynamic processes underlying body-vortex interactions that are frequently manifested in rotorcraft and propeller-driven fixed-wing aircraft wakes. In particular, the presence of negative vorticity in the inner core of a vortex filament (one example of which is examined in this paper) subsequent to "cutting" by a solid body has a profound influence on the vortex reconnection, leading to analog flow behavior similar to vortex breakdown phenomena described in the literature. Initial vorticity distributions (three specific examples which are examined) without an inner core of negative vorticity do not exhibit vortex breakdown and instead manifest diffusion-like properties while undergoing vortex reconnection. Though this work focuses on laminar vortical flow, this work is anticipated to provide valuable insight into rotary-wing aerodynamics as well as other types of vortical flow phenomena.

Developing a Manualized Occupational Therapy Diabetes Management Intervention: Resilient, Empowered, Active Living With Diabetes.

PubMed

Pyatak, Elizabeth A; Carandang, Kristine; Davis, Shain

2015-07-01

This article reports on the development of a manualized occupational therapy intervention for diabetes management. An initial theoretical framework and core content areas for a Stage I intervention manual were developed based on an in-depth needs assessment and review of existing literature. After evaluation by a panel of experts and completion of a feasibility study, the intervention was revised into a Stage 2 manual in preparation for a randomized study evaluating the intervention's efficacy. In developing the initial manual, we delineated core theoretical principles to allow for flexible application and tailoring of the intervention's content areas. Expert panel feedback and feasibility study results led to changes to the intervention structure and content as we developed the Stage 2 manual. Through describing this process, we illustrate the dynamic evolution of intervention manuals, which undergo revisions due to both theoretical and practical considerations at each stage of the research-to-clinical practice pipeline.

Ceres: Evolution and Present State

NASA Astrophysics Data System (ADS)

Castillo-Rogez, J.; McCord, T.

2007-08-01

Introduction:We consider Ceres as a prototype for planetary evolution [1]. From thermal modeling by McCord and Sotin [2, 3, 4], Ceres was inferred to have differentiated into a rocky core of hydrated silicates, and an icy outer shell. Thomas et al. [5] confirmed such a model from direct observation of Ceres's shape from Hubble Space Telescope observations, and pervious occultation measurements. McCord and Sotin [4] also suggest that Ceres could have preserved a deep ocean, especially if ammonia or some other ice melting point depressant, such as salts, was incorporated during accretion. We continue to develop thermal modeling of Ceres, using increasingly sophisticated models and new observational information in order to match the observed shape. . In particular, we investigate the evolution of the core. Approach: Our models require the following initial input: initial planetesimal temperature (after [6]); composition; time of formation with respect to Calcium-Aluminum Inclusions (CAIs); and an internal heat profile after initial accretion. Modeling begins with a porous Ceres (after [7, 8]). The rock phase has the composition of an ordinary chondrite (after [9]). Short-lived radiogenic isotopes, including 26Al and 60Fe, have initial concentrations as measured by [10, 11]. Conductive thermal evolution is computed for one-dimensional models following the approach of [4] and [12]. The silicate core evolves through hydration, then dehydration and melting stages. Currently, hydrothermal cooling is not included in our algorithm. Model Results: Conditions were present for full differentiation of Ceres if accretion time t0-CAIs was less than 7 My and/or if ammonia was accreted. For times of formation t0-CAIs shorter than 2 My, the boiling point of water was reached within a few My after accretion, and may have led to major water loss.Under these conditions, hydrothermal activity was inevitable, and might still be taking place inside Ceres. Whether a deep ocean is still present within Ceres or not depends on the initial conditions, especially the presence of ammonia. The core follows very different evolutionary paths, given the range of input values. Core evolution is most strongly affected by the time of accretion, with respect to inclusion of CAIs. With the inclusion of short-lived radioisotopes, pressure and temperature conditions in the core can lead to dehydration of the silicate phase [13], and layering of the core. An outer layer consisting of hydrated silicates, and a deep core consisting of dry silicate is the result, due to the equation of state of hydrated silicates. Explosive volcanism is expected to occur [14]. Conditions can even lead to partial differentiation of a metallic core.It is these model runs, resulting in the differentiation of Ceres's core into an outer hydrated layer, dehydrated inner layer and a tiny metallic center, that also produce the observed shape. Acknowledgement: This work was supported in part by the NASA Dawn Discovery Program under contract to the Space Science Institute by the UCLA and funded by JPL/NASA. Part of this work was performed at the Jet Propulsion Laboratory - California Institute of Technology under contract to NASA. References: [1] McCord T. B. et al. 2006. Eos 87(10). [2] McCord, T. B., Sotin, C. 2003. American Astronomical Society, DPS meeting #35, #34.17; Bull. Amer. Astron. Soc. 35, 979. [3] McCord, T., Sotin, C. 2004. 35th COSPAR Scientific Assembly. Held 18 - 25 July 2004, in Paris, France., 1148. [4] McCord, T.B., C. Sotin 2005. J. Geophys. Res., 110, E05009, doi: 10.1029/2004JE002244. 1-14. [5] Thomas, P. C., et al. 2005. Nature 437, doi: 10.1038/nature03938, 224-226. [6] Mousis O. and Alibert Y. (2005) MNRAS, 358, 188-192. [7] Leliwa-Kopystynski, J., Kossacki, K. J. 1995. Planet. Space Sci. 43, 851-861. [8] Leliwa-Kopystynski, J., Kossacki, K. J. 2000. Planet. Space Sci. 48, 727-745. [9] Wasson, J. T., Kalleymen, G. W. 1988. Phil. Trans. Roy. Soc. London A 325, 535. [10] Wasserburg, G. J., Papanastassiou, D. A. 1982. in Essays in Nuclear Astrophysics, ed. C.A. Barnes, D.D. Clayton, & D.N. Schramm (New York: Cambridge Univ. Press), 77. [11] Tachibana, S., et al. 2006. Astroph. J., 639, L87-L90, doi: 10.1086/503201. [12] Castillo et al. Submitted to Icarus. [13] Ellis D. E., Wyllie P. J. 1979. Am. Miner. 64, 41-48. [14] Wilson L. et al. (1999) MPS, 34, 541-557.