Science.gov

Sample records for ms research title

  1. "Miss"ing Me and "Ms"ing the Other: Courtesy Titles for Women in Englishes

    ERIC Educational Resources Information Center

    Winter, Joanne; Pauwels, Anne

    2007-01-01

    The introduction and spread of "Ms" as the courtesy address title for women is a cornerstone of feminist linguistic planning for English. Its introduction aimed to eradicate the discriminatory inequity in the address system that exposed women through their (non)marital relationship with men. The understanding, use and impact of the courtesy title…

  2. A Corpus-Based Syntactic Study of Medical Research Article Titles

    ERIC Educational Resources Information Center

    Wang, Yan; Bai, Yongquan

    2007-01-01

    English titles of medical research articles (RAs) are of great importance, the quality of which can, to a certain degree, affect impact factors of the articles, because many readers will make a decision as to whether to read on after reading titles. However, the special genre has not been extensively studied to date. This paper is designed to…

  3. Building Consistency between Title, Problem Statement, Purpose, & Research Questions to Improve the Quality of Research Plans and Reports

    ERIC Educational Resources Information Center

    Newman, Isadore; Covrig, Duane M.

    2013-01-01

    Consistency in the title, problem, purpose, and research question improve the logic and transparency of research. When these components of research are aligned research design and planning are more coherent and research reports are more readable. This article reviews the process for checking for and improving consistency. Numerous examples of…

  4. The application of MALDI TOF MS in biopharmaceutical research.

    PubMed

    Kafka, Alexandra P; Kleffmann, Torsten; Rades, Thomas; McDowell, Arlene

    2011-09-30

    The development and quality assessment of modern biopharmaceuticals, particularly protein and peptide drugs, requires an array of analytical techniques to assess the integrity of the bioactive molecule during formulation and administration. Mass spectrometry is one of these methods and is particularly suitable for determining chemical modifications of protein and peptide drugs. The emphasis of this review is the identification of covalent interactions between protein and peptide bioactives with polymeric pharmaceutical formulations using mass spectrometry with the main focus on matrix-assisted laser desorption/ionization (MALDI) coupled tandem time-of-flight (TOF/TOF) mass spectrometry (MS). The basics of MALDI TOF MS and collision-induced dissociation (CID)-based ion fragmentation will be explained and applications for qualitative characterization of protein and peptide drugs and their interactions with pharmaceutical polymers will be discussed using three case studies.

  5. Stepchild or Prodigy? Neuroprotection in Multiple Sclerosis (MS) Research

    PubMed Central

    Rottlaender, Andrea; Kuerten, Stefanie

    2015-01-01

    Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS) and characterized by the infiltration of immune cells, demyelination and axonal loss. Loss of axons and nerve fiber pathology are widely accepted as correlates of neurological disability. Hence, it is surprising that the development of neuroprotective therapies has been neglected for a long time. A reason for this could be the diversity of the underlying mechanisms, complex changes in nerve fiber pathology and the absence of biomarkers and tools to quantify neuroregenerative processes. Present therapeutic strategies are aimed at modulating or suppressing the immune response, but do not primarily attenuate axonal pathology. Yet, target-oriented neuroprotective strategies are essential for the treatment of MS, especially as severe damage of nerve fibers mostly occurs in the course of disease progression and cannot be impeded by immune modulatory drugs. This review shall depict the need for neuroprotective strategies and elucidate difficulties and opportunities. PMID:26140377

  6. Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS

    PubMed Central

    Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim

    2012-01-01

    Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS. PMID:22917690

  7. Limitations of Using Microsoft Excel Version 2016 (MS Excel 2016) for Statistical Analysis for Medical Research.

    PubMed

    Tanavalee, Chotetawan; Luksanapruksa, Panya; Singhatanadgige, Weerasak

    2016-06-01

    Microsoft Excel (MS Excel) is a commonly used program for data collection and statistical analysis in biomedical research. However, this program has many limitations, including fewer functions that can be used for analysis and a limited number of total cells compared with dedicated statistical programs. MS Excel cannot complete analyses with blank cells, and cells must be selected manually for analysis. In addition, it requires multiple steps of data transformation and formulas to plot survival analysis graphs, among others. The Megastat add-on program, which will be supported by MS Excel 2016 soon, would eliminate some limitations of using statistic formulas within MS Excel.

  8. The role of epidemiology in MS research: Past successes, current challenges and future potential.

    PubMed

    Simpson, Steve; Taylor, Bruce V; van der Mei, Ingrid

    2015-07-01

    Multiple sclerosis (MS) is a multifaceted condition, with a range of environmental, behavioural and genetic factors implicated in its aetiology and clinical course. Successes in advancing our appreciation of the roles of Epstein-Barr virus, vitamin D/UV and the HLA-DRB1 locus; and our greater understanding of these and related factors' modes of action in MS and other conditions, can be attributed in no small part to the work of generations of epidemiologists. Hardly content to rest on our laurels, however, there are yet a range of unsolved conundrums in MS, including some changes in epidemiological characteristics (e.g. increasing incidence and sex ratio), to say nothing of the unresolved parts regarding what underlies MS risk and its clinical course. There is evidence that epidemiology will continue to play a crucial role in unravelling the architecture of MS causation and clinical course. While classic epidemiological methods are ongoing, novel avenues for research include gene-environment interaction studies, the world of '-omic' research, and the utilisation of mobile and social media tools to both access and track study populations, which means that the epidemiological discoveries of the past century may be but a glimpse of our understanding in the next few decades.

  9. Efficiency, Accountability, and Equity Issues in Title I Schoolwide Program Implementation. Research in Educational Productivity.

    ERIC Educational Resources Information Center

    Wong, Kenneth K., Ed.; Wang, Margaret C., Ed.

    This collection of conference papers includes: (1) "Using Market Forces to Make Title I More Effective" (Marci Kanstoroom and Tyce Palmaffy); (2) "Making Economically Grounded Decisions about Comprehensive School Reform Models: Considerations of Costs, Effects, and Contexts" (Jennifer King Rice); (3) "Does Title I Money Matter? Federal…

  10. The Evaluation of the ESEA Title VII Spanish/English Bilingual Education Program: Research Design and Analytic Approaches.

    ERIC Educational Resources Information Center

    Coles, Gary J.

    The research design and analytic approaches used in the national evaluation of the Elementary Secondary Education Act (ESEA) Title VII Spanish/English Bilingual Education Program are described. This study evaluated the entire program, as opposed to individual projects, and had four goals: to (1) determine the cognitive and affective impact of…

  11. Research on China's System of Evaluating Teachers in Institutions of Higher Education for Professional Titles and Appointments

    ERIC Educational Resources Information Center

    Meirong, Che

    2005-01-01

    Evaluation for and appointment to professional titles is a major aspect of personnel management in institutions of higher education. Diligence in this area is important for firing the enthusiasm of the broad mass of teachers for their work and for the stable and sustainable development of university research work.

  12. Implementation of a single quad MS detector in high-throughput transdermal research of plant extracts.

    PubMed

    Veryser, Lieselotte; Taevernier, Lien; Roche, Nathalie; Blondeel, Phillip; De Spiegeleer, Bart

    2015-11-10

    In this study, a new type of single quadrupole mass spectrometric detector was implemented in transdermal research. The local skin pharmacokinetic properties of the plant N-alkylamides (NAAs) pellitorine and anacycline, present in an Anacyclus pyrethrum extract, and spilanthol, present in a Spilanthes acmella extract were investigated. This single quad MS detection method showed great advantages compared to the traditional UV detector. The NAAs could be identified and quantified in the samples with an ultra performance liquid chromatography (UPLC)-single quad MS detection system, even if they were not separated, which is a requirement when using an UV-detector. Another advantage of the UPLC-MS system is that lower limit of detection values could be obtained allowing a more accurate and precise determination of the experimental lag time in the in vitro skin permeation experiments. To conclude, this single quad MS detector coupled to UPLC is a useful analytical tool with improved performance compared to high performance liquid chromatography (HPLC)-UV for biomedical-pharmaceutical purposes in transdermal research. PMID:26320078

  13. Current titles

    SciTech Connect

    1995-07-01

    This booklet is published for those interested in current research being conducted at the National Center for Electron Microscopy. The NCEM is a DOE-designated national user facility and is available at no charge to qualified researchers. Access is controlled by an external steering committee. Interested researchers may contact Gretchen Hermes at (510) 486-5006 or address below for a User`s Guide. Copies of available papers can be ordered from: Theda Crawford National Center for Electron Microscopy, Lawrence Berkeley Laboratory, One Cyclotron Rd., MS72, Berkeley, California, USA 94720.

  14. Market Research Survey of Commercial Off-The-Shelf (COTS) Portable MS Systems for IAEA Safeguards Applications

    SciTech Connect

    Hart, Garret L.; Hager, George J.; Barinaga, Charles J.; Duckworth, Douglas C.

    2013-02-01

    This report summarizes the results for the market research survey of mass spectrometers that are deemed pertinent to International Atomic Energy Agency (IAEA) needs and strategic objectives. The focus of the report is on MS instruments that represent currently available (or soon to be) commercial off-the shelf (COTS) technology and weigh less than 400 pounds. A compilation of all available MS instruments (36 COTS and 2 R&D) is presented, along with pertinent information regarding each instrument.

  15. Scientific Research Database of the 2008 Ms8.0 Wenchuan Earthquake

    NASA Astrophysics Data System (ADS)

    Liang, C.; Yang, Y.; Yu, Y.

    2013-12-01

    Nearly 5 years after the 2008 Ms8.0 Wenchuan Earthquake, the Ms7.0 Lushan earthquake stroke 70km away along the same fault system. Given the tremendous life loss and property damages as well as the short time and distance intervals between the two large magnitude events, the scientific probing into their causing factors and future seismic activities in the nearby region will continue to be in the center of earthquake research in China and even the world for years to come. In the past five years, scientists have made significant efforts to study the Wenchuan earthquake from various aspects using different datasets and methods. Their studies cover a variety of topics including seismogenic environment, earthquake precursors, rupture process, co-seismic phenomenon, hazard relief, reservoir induced seismicity and more. These studies have been published in numerous journals in Chinese, English and many other languages. In addition, 54 books regarding to this earthquake have been published. The extremely diversified nature of all publications makes it very difficult and time-consuming, if not impossible, to sort out information needed by individual researcher in an efficient way. An information platform that collects relevant scientific information and makes them accessible in various ways can be very handy. With this mission in mind, the Earthquake Research Group in the Chengdu University of Technology has developed a website www.wceq.org to attack this target: (1) articles published by major journals and books are recorded into a database. Researchers will be able to find articles by topics, journals, publication dates, authors and keywords e.t.c by a few clicks; (2) to fast track the latest developments, researchers can also follow upon updates in the current month, last 90days, 180 days and 365 days by clicking on corresponding links; (3) the modern communication tools such as Facebook, Twitter and their Chinese counterparts are accommodated in this site to share

  16. REPORT OF THE FIRST RESEARCH PLANNING CONFERENCE HELD UNDER THE AUSPICES OF PROJECT LITERACY (TITLE SUPPLIED)--PROJECT LITERACY REPORTS, NO. 1.

    ERIC Educational Resources Information Center

    LEVIN, HARRY; AND OTHERS

    PROVIDED IN THIS REPORT ARE COMPLETE TEXTS OF THE PAPERS PRESENTED AT THE FIRST RESEARCH PLANNING CONFERENCE OF "PROJECT LITERACY." THE CENTRAL THEME OF EACH PAPER IS BASIC RESEARCH AND/OR CURRICULUM DEVELOPMENT IN AREAS OF EDUCATION RELEVANT TO THE ACQUISITION OF READING SKILLS. TITLES OF THE 12 PAPERS PRESENTED ARE (1) "AROUSAL--IMPLICATIONS FOR…

  17. Critical Issues in Parental Involvement: A Collection of Research Summaries by Title VII Graduate Students.

    ERIC Educational Resources Information Center

    Bermudez, Andrea B., Ed.; Rakow, Steven J., Ed.; Ensle, Anne Labay, Ed.

    This volume contains 18 summaries of research on parental involvement, carried out by inservice teachers completing a Master's degree in multicultural studies. All but one of the participants were certified Texas teachers working in bilingual and English-as-a-Second-Language (ESL) education. Their research critically examined many facets of the…

  18. Triple Quad-ICP-MS Measurement of Toxic Metals in Mainstream Cigarette Smoke from Spectrum Research Cigarettes.

    PubMed

    Pappas, R Steven; Gray, Naudia; Gonzalez-Jimenez, Nathalie; Fresquez, Mark; Watson, Clifford H

    2016-01-01

    We previously reported toxic metal concentrations in the mainstream smoke from 50 varieties of commercial cigarettes available in the USA using quadrupole inductively coupled plasma-mass spectrometry (ICP-MS). However, efforts to continue producing high quality data on select mainstream cigarette smoke constituents demand continued improvements in instrumentation and methodology and application of the methodology to cigarettes that differ in design or construction. Here we report a new application of 'triple quad'-ICP-MS instrumentation to analyze seven toxic metals in mainstream cigarette smoke from the Spectrum variable nicotine research cigarettes. The Spectrum cigarettes are available for research purposes in different configurations of low or conventional levels of nicotine, mentholated or nonmentholated, and tar delivery ranges described as 'low tar' or 'high tar'. Detailed characterizations of specific harmful or potentially harmful constituents delivered by these research cigarettes will help inform researchers using these cigarettes in exposure studies, cessation studies and studies related to nicotine addiction or compensation.

  19. The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory.

    PubMed

    Morris, Chris; Pajon, Anne; Griffiths, Susanne L; Daniel, Ed; Savitsky, Marc; Lin, Bill; Diprose, Jonathan M; da Silva, Alan Wilter; Pilicheva, Katya; Troshin, Peter; van Niekerk, Johannes; Isaacs, Neil; Naismith, James; Nave, Colin; Blake, Richard; Wilson, Keith S; Stuart, David I; Henrick, Kim; Esnouf, Robert M

    2011-04-01

    The techniques used in protein production and structural biology have been developing rapidly, but techniques for recording the laboratory information produced have not kept pace. One approach is the development of laboratory information-management systems (LIMS), which typically use a relational database schema to model and store results from a laboratory workflow. The underlying philosophy and implementation of the Protein Information Management System (PiMS), a LIMS development specifically targeted at the flexible and unpredictable workflows of protein-production research laboratories of all scales, is described. PiMS is a web-based Java application that uses either Postgres or Oracle as the underlying relational database-management system. PiMS is available under a free licence to all academic laboratories either for local installation or for use as a managed service. PMID:21460443

  20. The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory.

    PubMed

    Morris, Chris; Pajon, Anne; Griffiths, Susanne L; Daniel, Ed; Savitsky, Marc; Lin, Bill; Diprose, Jonathan M; da Silva, Alan Wilter; Pilicheva, Katya; Troshin, Peter; van Niekerk, Johannes; Isaacs, Neil; Naismith, James; Nave, Colin; Blake, Richard; Wilson, Keith S; Stuart, David I; Henrick, Kim; Esnouf, Robert M

    2011-04-01

    The techniques used in protein production and structural biology have been developing rapidly, but techniques for recording the laboratory information produced have not kept pace. One approach is the development of laboratory information-management systems (LIMS), which typically use a relational database schema to model and store results from a laboratory workflow. The underlying philosophy and implementation of the Protein Information Management System (PiMS), a LIMS development specifically targeted at the flexible and unpredictable workflows of protein-production research laboratories of all scales, is described. PiMS is a web-based Java application that uses either Postgres or Oracle as the underlying relational database-management system. PiMS is available under a free licence to all academic laboratories either for local installation or for use as a managed service.

  1. The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory

    PubMed Central

    Morris, Chris; Pajon, Anne; Griffiths, Susanne L.; Daniel, Ed; Savitsky, Marc; Lin, Bill; Diprose, Jonathan M.; Wilter da Silva, Alan; Pilicheva, Katya; Troshin, Peter; van Niekerk, Johannes; Isaacs, Neil; Naismith, James; Nave, Colin; Blake, Richard; Wilson, Keith S.; Stuart, David I.; Henrick, Kim; Esnouf, Robert M.

    2011-01-01

    The techniques used in protein production and structural biology have been developing rapidly, but techniques for recording the laboratory information produced have not kept pace. One approach is the development of laboratory information-management systems (LIMS), which typically use a relational database schema to model and store results from a laboratory workflow. The underlying philosophy and implementation of the Protein Information Management System (PiMS), a LIMS development specifically targeted at the flexible and unpredictable workflows of protein-production research laboratories of all scales, is described. PiMS is a web-based Java application that uses either Postgres or Oracle as the underlying relational database-management system. PiMS is available under a free licence to all academic laboratories either for local installation or for use as a managed service. PMID:21460443

  2. Pediatric MS

    MedlinePlus

    ... of the oral medications in the pediatric population. Network of Pediatric MS Centers The National MS Society ... MS Study Group (2004) and established a nationwide network of six Pediatric MS Centers of Excellence (2006) ...

  3. Title Requested

    NASA Astrophysics Data System (ADS)

    Limaye, S. S.; Prabhu, T.; Bhatt, B. C.; Anandrao, B. G.; Emerson, G.; Young, E. F.

    2004-11-01

    In order to obtain a better dataset for tracking features in near infrared images of Venus, coordinated observations were made from two telescopes in India - the 1m Mt. Abu telescope at Gurushikhar (Location: 24o 39' 8.8" North Latitude, 72o 46' 47.47", 1680 m above MSL, NICMOS III camera, 0.5 arcsec/pixel) and the 2m Optical-Infrared Himalayan Chandra Telescope at Hanle, Ladakh (32o 35' 46" North Latitude and 78o 57' 51" East Longitude, 4500 m above MSL, NIR Camera, 0.21 arcsec/pixel) during 4-10 May 2004 and 6 -10 July 2004 when similar observations were also made from IRTF (Young et al., 2004) and Nordic Optical Telescope (Warell et al., 2004) as well as APO and AAT. Images were obtained at 2.29 micron wavelength using the filters available at the telescopes and show considerable variability from day to day in the atmospheric features. Yet there is enough retention of structural features that suggest a lifetime of 7 days indicating one complete rotation as observed from HCT data taken in May 2004. These features are believed to originate at 52 km level above the Venus surface and the motions are consistent with a rotation rate of 63 m/s at the equator. When combined with those from NOT, IRTF, APO and AAT these observations will yield better information about the circulation at 52 km altitude than has been possible from previous observations. We acknowledge the support and hospitality extended to us to obtain these observations by the staff of Mt. Abu and the Chandra telescopes, in particular Rajesh Shat and Jinesh Jain. Mt. Abu Telescope is operated by Physical Research Laboratory (Ahmedabad, India) and the Chandra Telescope is operated by Center for Research and Education in Science and Technology, Indian Institute of Astrophysics (Bangalore, India). Both are supported by the Indian Space Research Organization

  4. The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory

    SciTech Connect

    Morris, Chris; Pajon, Anne; Griffiths, Susanne L.; Daniel, Ed; Savitsky, Marc; Lin, Bill; Diprose, Jonathan M.; Wilter da Silva, Alan; Pilicheva, Katya; Troshin, Peter; Niekerk, Johannes van; Isaacs, Neil; Naismith, James; Nave, Colin; Blake, Richard; Wilson, Keith S.; Stuart, David I.; Henrick, Kim; Esnouf, Robert M.

    2011-04-01

    The Protein Information Management System (PiMS) is described together with a discussion of how its features make it well suited to laboratories of all sizes. The techniques used in protein production and structural biology have been developing rapidly, but techniques for recording the laboratory information produced have not kept pace. One approach is the development of laboratory information-management systems (LIMS), which typically use a relational database schema to model and store results from a laboratory workflow. The underlying philosophy and implementation of the Protein Information Management System (PiMS), a LIMS development specifically targeted at the flexible and unpredictable workflows of protein-production research laboratories of all scales, is described. PiMS is a web-based Java application that uses either Postgres or Oracle as the underlying relational database-management system. PiMS is available under a free licence to all academic laboratories either for local installation or for use as a managed service.

  5. MS Detectors

    SciTech Connect

    Koppenaal, David W.; Barinaga, Charles J.; Denton, M Bonner B.; Sperline, Roger P.; Hieftje, Gary M.; Schilling, G. D.; Andrade, Francisco J.; Barnes IV., James H.

    2005-11-01

    Good eyesight is often taken for granted, a situation that everyone appreciates once vision begins to fade with age. New eyeglasses or contact lenses are traditional ways to improve vision, but recent new technology, i.e. LASIK laser eye surgery, provides a new and exciting means for marked vision restoration and improvement. In mass spectrometry, detectors are the 'eyes' of the MS instrument. These 'eyes' have also been taken for granted. New detectors and new technologies are likewise needed to correct, improve, and extend ion detection and hence, our 'chemical vision'. The purpose of this report is to review and assess current MS detector technology and to provide a glimpse towards future detector technologies. It is hoped that the report will also serve to motivate interest, prompt ideas, and inspire new visions for ion detection research.

  6. National Research Council Dialogue to Assess Progress on NASA's Title of CRM Capability Roadmap Development: General Background and Introduction

    NASA Technical Reports Server (NTRS)

    Crooke, Julie A.

    2005-01-01

    Contents include the following: General Background and Introduction of Capability Roadmaps "Title." Agency Objective. Strategic Planning Transformation. Advanced Planning Organizational Roles. Public Involvement in Strategic Planning. Strategic Roadmaps and Schedule. Capability Roadmaps and Schedule. Purpose of NRC Review. Capability Roadmap Development (Progress to Date).

  7. Title VII Enhancement Project for Compartiendo Culturas/Sharing Cultures 1995-96. Research Report on Educational Programs.

    ERIC Educational Resources Information Center

    Houston Independent School District, TX. Dept. of Research and Evaluation.

    Compartiendo Culturas/Sharing Cultures, a Title VII Two-Way Developmental Bilingual Education Program at the Gary L. Herod Elementary School in the Houston Independent School District (Texas) was designed to end the isolation typically experienced by language minority students in traditional bilingual education and to provide language majority…

  8. The P.O.E.Ms of Educational Research: A Beginners' Concise Guide

    ERIC Educational Resources Information Center

    Mustafa, Rami F.

    2011-01-01

    Embarking in an educational research paper is one of the daunting processes any scholar can go through. And the process is even harder for novice education students who wander through the plethora of terminology, styles and paradigms trying to figure out their way in that jungle called educational research. The following of the review presents the…

  9. Current Titles

    SciTech Connect

    Various

    2006-06-01

    This booklet is published for those interested in current research being conducted at the National Center for Electron Microscopy. The NCEM is a DOE-designated national user facility and is available at no charge to qualified researchers. Access is controlled by an external steering committee. Interested researchers may contact Jane Cavlina, Administrator, at 510/486-6036.

  10. Current titles

    SciTech Connect

    Not Available

    1993-04-01

    116 abstracts are presented of work done with the electron microscope. NCEM is a DOE-designated national user facility and is available at no charge to qualified researchers (assess is controlled by a steering committee).

  11. Feasibility Research on Alternative Approaches for Sampling and Extraction Methods in the TO-4A Method for Pesticides in Ambient Air with Analysis by GC/MS and LC/MS/MS

    EPA Science Inventory

    This compilation of methods is the result of a Regional Methods project between the U.S. Environmental Protection Agency Region 4 and the EPA’s Office of Research and Development. The research leading to these methods was conducted in response to an observed need to update an EPA...

  12. Assessment of the tung tree (Vernicia fordii) germplasm collection and latest cultivar release at the USDA-ARS Southern Horticultural Research Unit in Poplarville, MS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Tung trees (Vernicia fordii, syn Aleurites fordii) and tung oil production have a long history in the gulf coast region. The Thad Cochran Southern Horticultural Laboratory (TCSHL) in Poplarville, MS was formerly the USDA Tung Oil Research Station in the 1940s, 50s and 60s and still maintains an exte...

  13. 32 CFR 644.68 - Title Clearance-Certificate of Title and Title Insurance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Title Clearance-Certificate of Title and Title... (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Acquisition Procurement of Title Evidence, Title Clearance, and Closings § 644.68 Title Clearance—Certificate of Title and Title Insurance. (a) Curative...

  14. Early American Textbooks, 1775-1900. A Catalog of the Titles Held by the Educational Research Library.

    ERIC Educational Resources Information Center

    Svobodny, Dolly, Ed.

    Intended as an educational resource for use in the study of the early development of education in the United States, this catalog, prepared by the Educational Research Library of the U.S. Department of Education's Office of Educational Research and Improvement, contains bibliographic descriptions for more than 6,000 textbooks published from 1775…

  15. Title X and its critics.

    PubMed

    Rosoff, J I; Kenney, A M

    1984-01-01

    On Arpil 5, 1984 Senator Jesse Helms (R.--NC) was the leadd witness at a hearing before the US Senate Labor and Human Resources Subcommittee on Family and Human Services. The subcommittee was considering the renewal of Title X of the Public Health Service Act, the main national family planning legislation. Helm's prepared text (given in this article) was noteworthy not only for its hyperbole but also for its tone of intense frustration and for its repetition of the main themes enunciated by those less well known and less powerful who have opposed the program since it began. Title X was 1st enacted in 1970 and was reenacted in 1973, 1975, 1977, 1978 and 1981. The program has always had its share of critics; but in the late 1970's with the emergence of the New Right, such groups moved into political power. Title X provided for project grants to be made to public and private nonprofit agencies to provide contraceptive services along with training, technical assistance and other support activities. It also spelled out government responsibilities and functions in relation to human reproduction and population research; and it created the post of Deputy Assistant Secretary for Population Affairs, with direct responsibility for both types of activities within the Department of Health and Human Services. Eligibility for services was broad--applying to all who need and want services, with priority for low-income persons. A requirement of voluntary participation and a prohibition of the use of Title X funds for abortion as a family planning method were clearly stated. Title X has been criticized by Catholics and many other groups. This article attempts to meet criticisms aimed at the functioning, appropriateness and impact of the Title X program, and summarizes the findings of a large body of socialogical and demographic research that has direct or indirect bearing on the issues raised by the critics.

  16. [Research and Application of the ICP-MS Detection Technology for the Content of Nb and Ta in Geochemical Sample].

    PubMed

    Li, Zi-qiang; Li, Xiao-ying; Zhu, Kun; Xu, Xiao-xia; Yan, Zhi-yuan

    2015-08-01

    In order to provide the test analysis technology to support the exploration and development of niobium and tantalum resource, based on the special chemical properties of Nb and Ta in geochemical sample, we studied the detection methods for the content of Nb and Ta in geochemical sample by using inductively coupled plasma mass spectrometry (ICP-MS). The results show that the sample dissolution and instrumental parameter of ICP-MS, especially the former have significant influence? on detection results. Therefore, optimizing important parameters of sample dissolution is the key of the detection technology. The optimal parameters are that the weight of sample is 50 mg; the dosage of HF acid is 15 mL; the concentration of nitric acid and tartaric acid in the sample solution is 2% and 1.5%, respectively; the validity period of detection for sample solution ≤1 d. The detection method has been validated by the national geochemistry standard reference material. The precise and exaction of method meet the required of industry standards. The detection limits of method for Nb and Ta are 1.05 and 0.13 μg · g(-1), respectively. The experiment proved that the ICP-MS detection methods, which using certain preparation process of sample solutions, is suitable for accurate and rapid determination of Nb and Ta in geochemical sample, especially geochemical survey samples which with a large amount and low content of Nb and Ta. PMID:26672313

  17. MS Based Metabonomics

    SciTech Connect

    Want, Elizabeth J.; Metz, Thomas O.

    2010-03-01

    Metabonomics is the latest and least mature of the systems biology triad, which also includes genomics and proteomics, and has its origins in the early orthomolecular medicine work pioneered by Linus Pauling and Arthur Robinson. It was defined by Nicholson and colleagues in 1999 as the quantitative measurement of perturbations in the metabolite complement of an integrated biological system in response to internal or external stimuli, and is often used today to describe many non-global types of metabolite analyses. Applications of metabonomics are extensive and include toxicology, nutrition, pharmaceutical research and development, physiological monitoring and disease diagnosis. For example, blood samples from millions of neonates are tested routinely by mass spectrometry (MS) as a diagnostic tool for inborn errors of metabolism. The metabonome encompasses a wide range of structurally diverse metabolites; therefore, no single analytical platform will be sufficient. Specialized sample preparation and detection techniques are required, and advances in NMR and MS technologies have led to enhanced metabonome coverage, which in turn demands improved data analysis approaches. The role of MS in metabonomics is still evolving as instrumentation and software becomes more sophisticated and as researchers realize the strengths and limitations of current technology. MS offers a wide dynamic range, high sensitivity, and reproducible, quantitative analysis. These attributes are essential for addressing the challenges of metabonomics, as the range of metabolite concentrations easily exceeds nine orders of magnitude in biofluids, and the diversity of molecular species ranges from simple amino and organic acids to lipids and complex carbohydrates. Additional challenges arise in generating a comprehensive metabolite profile, downstream data processing and analysis, and structural characterization of important metabolites. A typical workflow of MS-based metabonomics is shown in Figure

  18. [Analysis and research on the degradation and migration of organic pollutants in textile wastewater treatment process by GC-MS].

    PubMed

    Liu, Wei-jing; Zhang, Long; Wu, Wei; Tu, Yong

    2010-04-01

    In order to analyze the advantages/disadvantages of the combined treatment process between "physicochemical + biochemical" and "biochemical + physicochemical" in treatment of textile wastewater, gas chromatography-mass spectrometry (GC-MS) was used to determine the degradation process of organic pollutants in this two totally different treatment processes. The same analysis was also conducted to the sludge and discharged water. The results showed that the "physicochemical + biochemical" process displayed a poorer effect than "biochemical + physicochemical" in degrading the organic pollutants. The latter was 6.2% higher than the former in removing the organic pollutants averagely. The difference was mainly manifested in the efficiency of anaerobic hydrolysis in the two coupled processes. Moreover, the implement of "physicochemical + biochemical" process resulted in the migration of plenty of typical organic pollutants to sludge from primary coagulation sedimentation process and to the discharged water, which would cause secondary pollution easily.

  19. [Regional effect research of blood lead concentrations and isotopic fingerprints in four cities by ICP-MS].

    PubMed

    Zeng, Jing; Wang, Jing-Yu; Liu, Ya-Qiong; Xie, Qing; Ouyang, Li

    2011-11-01

    Blood lead is a reflection of environment lead in vivo, its concentration could be used to assess lead exposure of environment quantitatively, and its isotopic ratio could be used to fingerprint environment source qualitatively. In the present study, concentrations and isotopic ratios of blood lead (BPb) of four cities in China were measured by ICP-MS for the first time. The regional effects of BPb in four Chinese cities were observed in our study. The BPb levels of industrial cities (Taiyuan and Chengdu) are higher than that of non-industrial cities (Suzhou and Beijing), indicating that industrial pollution remains primary lead contamination factor. The BPb isotopic ratios are diverse with the different character of environment the individuals live in. Food-borne lead probably has replaced the air-borne lead to be the major source of BPb in Beijing. Besides, regional effect of BPb in some developed cities is partly weakened by diversity of vast majority of imported resources.

  20. No latest title...

    THOMAS, 112th Congress

    Rep. Mica, John L. [R-FL-7

    2012-04-16

    07/06/2012 Became Public Law No: 112-141. (TXT | PDF) (All Actions) Notes: Division F of the conference report includes Flood Insurance Reform and Modernization (Title II) and Student Loan Interest Rate Extension (Title III). Tracker: This bill has the status Became LawHere are the steps for Status of Legislation:

  1. Linking Resource Allocation to Student Achievement: A Study of Title 1 and Title 1 Stimulus Utilization

    ERIC Educational Resources Information Center

    Krumpe, Kati P.

    2012-01-01

    With the emphasis on high standards and fiscal accountability, there is a heightened need to inform the research linking student achievement to the allocation of resources. This mixed methods inquiry sought to study how schools utilized Title 1 and Title 1 stimulus funding from 2009-2011 to determine if correlations existed between areas of…

  2. Research of Herb-Partitioned Moxibustion for Primary Dysmenorrhea Patients Based on the LC-MS Metabonomics.

    PubMed

    Ma, Yu-Xia; Yang, Xing-Yue; Guo, Gang; Du, Dong-Qing; Yu, Yan-Pu; Gao, Shu-Zhong

    2015-01-01

    Objective. To explore the efficacy and mechanism of primary dysmenorrhea patients were treated with herb-partitioned moxibustion through metabonomics. Methods. 20 patients with primary dysmenorrhea were randomized into two groups, separately treated with herb-partitioned moxibustion at CV8 (shenque) and acupuncture at SP6 (sanyinjiao). After three menstrual cycles' treatment, the intensity of menstrual pain using VAS and the changes of metabolites of plasma using LC-MS were observed. Results. The VAS of two groups decreased with different descending range. Herb-partitioned moxibustion upregulated 20α-dihydroprogesterone, pregnenolone, prostaglandin E2 and γ-aminobutyric acid and downregulated the content of estrone and prostaglandin H2, while acupuncture upregulated pregnenolone and 20α-dihydroprogesterone and downregulated 2-methoxyestradiol-3-methylether, 15-hydroxyeicosatrienoic acid and 6-keto-prostaglandin. Discussion. It was effective in relieving the abdominal pain by these two therapies. Herb-partitioned moxibustion is superior to acupuncture for primary dysmenorrhea, which could be related to regulating the endocrine hormone. PMID:26229545

  3. 32 CFR 644.68 - Title Clearance-Certificate of Title and Title Insurance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Title Clearance-Certificate of Title and Title Insurance. 644.68 Section 644.68 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Acquisition Procurement of Title Evidence, Title...

  4. Title IV-A Works Toward Total Child Development: John B. Gordon Elementary School, 1972-73. Research and Development Report, Volume 7, Number 25, December, 1973.

    ERIC Educational Resources Information Center

    McWilliams, Joyce H.; Wells, Veronica

    Gordon Elementary School had three supplementary programs during 1972-73 which were funded by federal, state, and local monies. Title IV-A is a federally funded program based on a "total family" approach to treating problems of the child and his education. Health, recreation, and physical fitness; remediation; family counseling; cultural…

  5. Roles, Titles and Opinions of Selected State Extension Sheep Specialists, A Partial Summary of a Nationwide Survey. A Research Summary of a Graduate Study.

    ERIC Educational Resources Information Center

    Kazzal, Najeeb T.; And Others

    This survey-type study had the following purposes: (1) to consider the sheep and Extension sheep situation and trends in the nation; (2) to gather information regarding titles and duties of sheep specialists; (3) to collect copies of available job descriptions; and (4) to identify some reasons why sheep numbers have continued to decline.…

  6. Homosexuals and Title VII

    ERIC Educational Resources Information Center

    Rivera, Juan R.; Galvan, Richard J.

    1975-01-01

    A method of dealing with the problems of discrimination against homosexuals in private employment through the application of Title VII of the Civil Rights Act of 1964 is discussed. The scope of the paper is limited to male homosexuals. (LBH)

  7. Employee Communication at the NASA Langley Research Center. M.S. Thesis - Coll. of William and Mary

    NASA Technical Reports Server (NTRS)

    Bendura, R. J.

    1972-01-01

    The means of employee communication at the NASA Langley Research Center are reported, and their effectiveness evaluated. The history, purpose, and structure of the organization as well as the employee educational background and salary status are discussed. Some of the approaches used by Langley Research Center management in communicating with their men are addressed and compared with recommendations of experts in employee communication. The results of personal interviews involving both employee and management assessment of management-employee communication are presented and evaluated. Employees need a great deal more recommunication from management providing rationale behind the cancellation of existing projects or the disapproval of proposed research projects. Also NASA management needs to establish a policy and guidelines for the rapid and simultaneous dissemination of all non-restricted information to employees during organizational activities having potential adverse effects on large numbers of personnel. Finally some improvements should be made in employee orientation procedures.

  8. Parameter identification studies on the NASA/Ames Research Center Advanced Concepts Flight Simulator. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Mckavitt, Thomas P., Jr.

    1990-01-01

    The results of an aircraft parameters identification study conducted on the National Aeronautics and Space Administration/Ames Research Center Advanced Concepts Flight Simulator (ACFS) in conjunction with the Navy-NASA Joint Institute of Aeronautics are given. The ACFS is a commercial airline simulator with a design based on future technology. The simulator is used as a laboratory for human factors research and engineering as applied to the commercial airline industry. Parametric areas examined were engine pressure ratio (EPR), optimum long range cruise Mach number, flap reference speed, and critical take-off speeds. Results were compared with corresponding parameters of the Boeing 757 and 767 aircraft. This comparison identified two areas where improvements can be made: (1) low maximum lift coefficients (on the order of 20-25 percent less than those of a 757); and (2) low optimum cruise Mach numbers. Recommendations were made to those anticipated with the application of future technologies.

  9. Research

    ERIC Educational Resources Information Center

    Mathematics Teaching, 1973

    1973-01-01

    Implications for teachers from Piagetian-oriented piagetian-oriented research on problem solving reported in an article by Eleanor Duckworth are presented. Edward de Bono's Children Solve Problems,'' a collection of examples, is also discussed. (MS)

  10. Status and use of HPLC-DAD/APCI-MS and direct flame sampling/APCI-MS for fullerenes and PAH research. First annual technical report for instrumentation grant, Project period 1 August 1992--31 July 1994

    SciTech Connect

    Howard, J.B.; Lafleur, A.L.; Taghizadeh, K.

    1994-08-01

    The PE/Sciex APCI/LC-MS equipment consists of a high performance liquid chromatograph (HPLC) with diode array spectrophotometric detector (DAD) interfaced to an atmospheric pressure ionizer with a single quadrupole mass spectrometer (MS) through a heated nebulizer. The interface between the HPLC and the MS is designed to minimize thermal input to the HPLC eluents and is of great importance for the authors intended application. Ionization occurs in a unique fashion at atmospheric pressure using a chemical ionization source (APCI). The equipment is being used for the identification and quantification of flame-generated fullerenes and polycyclic aromatic hydrocarbons (PAH). The mode of operation of this instrument is as follows: (1) complex mixtures are separated by the HPLC; (2) UV spectra of separated components are obtained by the diode array detector (DAD) as they elute from the HPLC; (3) components undergo mild ionization in the APCI source; and, (4) mass spectra are acquired by the mass spectrometer.

  11. Oversight on Family Planning Programs under Title X of the Public Health Service Act, 1984. Hearings before the Subcommittee on Family and Human Services of the Committee on Labor and Human Resources. United States Senate, Ninety-Eighth Congress, Second Session on Consideration of the Reauthorization of Title X of the Public Health Service Act, the Population Research and Voluntary Family Planning Programs (April 5 and May 1, 1984).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

    This document provides witness testimony and prepared statements from two sessions of the congressional hearing called to consider the reauthorization of Title X of the Public Health Service Act, the Population Research and Voluntary Family Planning Programs. Testimony is provided from the federal administration, state officials, representatives…

  12. No latest title...

    THOMAS, 112th Congress

    Sen. Brown, Sherrod [D-OH

    2012-04-16

    08/02/2012 Resolution agreed to in Senate with an amendment and an amendment to the Title and an amended preamble by Unanimous Consent. (text: CR S6011) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  13. No latest title...

    THOMAS, 113th Congress

    Sen. Hoeven, John [R-ND

    2013-05-23

    06/13/2013 Resolution agreed to in Senate with an amendment and an amendment to the Title and an amended preamble by Unanimous Consent. (text: CR S4495) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  14. No latest title...

    THOMAS, 113th Congress

    Sen. Durbin, Richard [D-IL

    2013-12-11

    01/07/2014 Resolution agreed to in Senate without amendment and an amendment to the Title and with a preamble by Unanimous Consent. (consideration: CR S82; text as passed Senate: CR S82) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  15. No latest title...

    THOMAS, 112th Congress

    Rep. Buerkle, Ann Marie [R-NY-25

    2011-06-01

    10/11/2011 The title of the measure was amended. Agreed to without objection. (All Actions) Notes: For further action, see H.R.1627, which became Public Law 112-154 on 8/6/2012. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  16. No latest title...

    THOMAS, 113th Congress

    Sen. Rubio, Marco [R-FL

    2014-05-22

    07/24/2014 Resolution agreed to in Senate without amendment and an amendment to the Title and an amended preamble by Unanimous Consent. (text: CR S4973) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  17. No latest title...

    THOMAS, 112th Congress

    Sen. Coons, Christopher A. [D-DE

    2012-03-21

    08/02/2012 Resolution agreed to in Senate with an amendment and an amendment to the Title and an amended preamble by Unanimous Consent. (text: CR S6009-6010) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  18. GeLC-MS/MS Analysis of Complex Protein Mixtures

    PubMed Central

    Dzieciatkowska, Monika; Hill, Ryan; Hansen, Kirk C.

    2015-01-01

    Discovery-based proteomics has found its place in nearly every facet of biological research. A key objective of this approach is to maximize sequence coverage for proteins across a wide concentration range. Fractionating samples at the protein level is one of the most common ways to circumvent challenges due to sample complexity and improve proteome coverage. Of the available methods, one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by liquid chromatography-tandem mass spectrometry (GeLC-MS/MS) is a robust and reproducible method for qualitative and quantitative proteomic analysis. Here we describe a general GeLC-MS/MS protocol and include technical advice and outline caveats to increase the probability of a successful analysis. PMID:24791981

  19. METLIN: MS/MS metabolite data from the MAGGIE Project

    DOE Data Explorer

    METLIN is a metabolite database for metabolomics containing over 50,000 structures, it also represents a data management system designed to assist in a broad array of metabolite research and metabolite identification by providing public access to its repository of current and comprehensive MS/MS metabolite data. An annotated list of known metabolites and their mass, chemical formula, and structure are available on the METLIN website. Each metabolite is conveniently linked to outside resources such as the the Kyoto Encyclopedia of Genes and Genomes (KEGG) for further reference and inquiry. MS/MS data is also available on many of the metabolites. The list is expanding continuously as more metabolite information is being deposited and discovered. [from http://metlin.scripps.edu/] Metlin is a component of the MAGGIE Project. MAGGIE is funded by the DOE Genomics: GTL and is an acronym for "Molecular Assemblies, Genes, and Genomics Integrated Efficiently."

  20. 32 CFR 644.62 - Title evidence.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Title evidence. 644.62 Section 644.62 National... HANDBOOK Acquisition Procurement of Title Evidence, Title Clearance, and Closings § 644.62 Title evidence. (a) Acceptable Types of Title Evidence. (1) Certificates of title are acceptable title...

  1. A Title I Refinement: Alaska.

    ERIC Educational Resources Information Center

    Hazelton, Alexander E.; And Others

    Through joint planning with a number of school districts and the Region X Title I Technical Assistance Center, and with the help of a Title I Refinement grant, Alaska has developed a system of data storage and retrieval using microcomputers that assists small school districts in the evaluation and reporting of their Title I programs. Although this…

  2. Title I: Compensatory Education at the Crossroads. Sociocultural, Political and Historical Studies in Education.

    ERIC Educational Resources Information Center

    Borman, Geoffrey D., Ed.; Stringfield, Samuel C., Ed.; Slavin, Robert E., Ed.

    This collection of papers presents the most recent research on Title I federal compensatory education. Building on 35 years of research, development, and practical experience, the book presents evidence of various ways Title I can become a more effective program and instrument for school reform. The nine papers are: (1) "Title I: Its Legislative…

  3. Titles, Labels, and Names: A House of Mirrors

    ERIC Educational Resources Information Center

    Petersen, Greg

    2006-01-01

    Among the harshest critiques ever received during my doctoral coursework came from a professor who was noticeably perturbed that I had researched and written a paper on an artwork without considering the title in the interpretation and analysis of the work. The professor insisted that the title is necessary to understand the piece. As a diligent…

  4. 48 CFR 1335.014 - Government property and title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... title. 1335.014 Section 1335.014 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title. The designee authorized to determine that the policies in FAR 35.014(b)(1)-(4) will not apply regarding...

  5. 48 CFR 1335.014 - Government property and title.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Government property and title. 1335.014 Section 1335.014 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title....

  6. 48 CFR 1335.014 - Government property and title.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government property and title. 1335.014 Section 1335.014 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title....

  7. 48 CFR 1335.014 - Government property and title.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Government property and title. 1335.014 Section 1335.014 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title....

  8. 48 CFR 1335.014 - Government property and title.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government property and title. 1335.014 Section 1335.014 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title....

  9. No latest title...

    THOMAS, 112th Congress

    Rep. Inslee, Jay [D-WA-1

    2011-09-21

    09/19/2012 PERMISSION TO BE ADDED AS A COSPONSOR - Ms. Bonamici asked unanimous consent that she be added as a cosponsor of H.R. 2994 since the original sponsor is no longer a Member of Congress. Agreed to without objection. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  10. No latest title...

    THOMAS, 112th Congress

    Rep. Heller, Dean [R-NV-2

    2011-01-25

    05/11/2011 Ms. Berkley asked unanimous consent to be the first sponsor of H.R. 427, and to have the authority to add co-sponsors. Agreed to without objection. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  11. Analysis of Thiodiglycol: Validation of Semi-Volatile Analysis by HPLC-MS/MS by EPA Method MS777

    SciTech Connect

    Owens, J; Koester, C

    2008-07-24

    The Environmental Protection Agency's (EPA) Region 5 Chicago Regional Laboratory (CRL) developed a method for the analysis of thiodiglycol, the breakdown product of the sulfur mustard HD, in water by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS), titled Method EPA MS777 (hereafter referred to as EPA CRL SOP MS777). This draft standard operating procedure (SOP) was distributed to multiple EPA laboratories and to Lawrence Livermore National Laboratory, which was tasked to serve as a reference laboratory for EPA's Environmental Reference Laboratory Network (ERLN) and to develop and validate analytical procedures. The primary objective of this study was to verify the analytical procedures described in MS777 for analysis of thiodiglycol in aqueous samples. The gathered data from this study will be used to: (1) demonstrate analytical method performance; (2) generate quality control acceptance criteria; and (3) revise the SOP to provide a validated method that would be available for use during a homeland security event. The data contained in this report will be compiled, by EPA CRL, with data generated by other EPA Regional laboratories so that performance metrics of Method EPA MS777 can be determined.

  12. No latest title...

    THOMAS, 113th Congress

    Rep. Wilson, Frederica S. [D-FL-24

    2013-07-24

    09/18/2014 Motion to Discharge Committee filed by Ms. Wilson (FL). Petition No: 113-12. (Discharge petition text with signatures.) (All Actions) Notes: On 9/18/2014, a motion was filed to discharge the Committees on Ways and Means, Small Business, Education and the Workforce, the Judiciary, Transportation and Infrastructure, Financial Services, House Administration, Oversight and Government Reform, and the Budget from the... Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  13. Fate and Transport of Bacteriophage (MS2 and PRD1) During Field-Scale Infiltration at a Research Site in Los Angeles County, CA

    NASA Astrophysics Data System (ADS)

    Anders, R.; Chrysikopoulos, C. V.

    2003-12-01

    As the use of tertiary-treated municipal wastewater (recycled water) for replenishment purposes continues to increase, provisions are being established to protect ground-water resources by ensuring that adequate soil-retention time and distance requirements are met for pathogen removal. However, many of the factors controlling virus fate and transport (e.g. hydraulic conditions, ground-water chemistry, and sediment mineralogy) are interrelated and poorly understood. Therefore, conducting field-scale experiments using surrogates for human enteric viruses at an actual recharge basin that uses recycled water may represent the best approach for establishing adequate setback requirements. Three field-scale infiltration experiments were conducted at such a basin using bacterial viruses (bacteriophage) MS2 and PRD1 as surrogates for human viruses, bromide as a conservative tracer, and recycled water. The specific research site consists of a test basin constructed adjacent to a large recharge facility (spreading grounds) located in the Montebello Forebay of Los Angeles County, California. The soil beneath the test basin is predominantly medium to coarse, moderately sorted, grayish-brown sand. The first experiment was conducted over a 2-day period to determine the feasibility of conducting field-scale infiltration experiments using recycled water seeded with high concentrations of bacteriophage and bromide as tracers. Based on the results of the first experiment, a second experiment was completed when similar hydraulic conditions existed at the test basin. The third infiltration experiment was conducted to confirm the results obtained from the second experiment. Data were obtained for samples collected during the second and third field-scale infiltration experiments from the test basin itself and from depths of 0.3, 0.6, 1.0, 1.5, 3.0, and 7.6 m below the bottom of the test basin. These field-scale tracer experiments indicate bacteriophage are attenuated by removal and (or

  14. 76 FR 59304 - Technical Amendment; Updates to Titles of Officials, Office Names, and References

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ...; Updates to Titles of Officials, Office Names, and References AGENCY: National Marine Fisheries Service... titles of officials, office names, and addresses to be consistent with the same in part 600. The... this title, or a designee. Science and Research Director means the Director of one of the six...

  15. Analysis of Ethanolamines: Validation of Semi-Volatile Analysis by HPLC-MS/MS by EPA Method MS888

    SciTech Connect

    Owens, J; Vu, A; Koester, C

    2008-10-08

    The Environmental Protection Agency's (EPA) Region 5 Chicago Regional Laboratory (CRL) developed a method titled 'Analysis of Diethanolamine, Triethanolamine, n-Methyldiethanolamine, and n-Ethyldiethanolamine in Water by Single Reaction Monitoring Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS): EPA Method MS888'. This draft standard operating procedure (SOP) was distributed to multiple EPA laboratories and to Lawrence Livermore National Laboratory, which was tasked to serve as a reference laboratory for EPA's Environmental Reference Laboratory Network (ERLN) and to develop and validate analytical procedures. The primary objective of this study was to validate and verify the analytical procedures described in 'EPA Method MS888' for analysis of the listed ethanolamines in aqueous samples. The gathered data from this validation study will be used to: (1) demonstrate analytical method performance; (2) generate quality control acceptance criteria; and (3) revise the SOP to provide a validated method that would be available for use during a homeland security event. The data contained in this report will be compiled, by EPA CRL, with data generated by other EPA Regional laboratories so that performance metrics of 'EPA Method MS888' can be determined.

  16. Analysis of Carbamate Pesticides: Validation of Semi-Volatile Analysis by HPLC-MS/MS by EPA Method MS666

    SciTech Connect

    Owens, J; Koester, C

    2008-05-14

    The Environmental Protection Agency's (EPA) Region 5 Chicago Regional Laboratory (CRL) developed a method for analysis of aldicarb, bromadiolone, carbofuran, oxamyl, and methomyl in water by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS), titled Method EPA MS666. This draft standard operating procedure (SOP) was distributed to multiple EPA laboratories and to Lawrence Livermore National Laboratory, which was tasked to serve as a reference laboratory for EPA's Environmental Reference Laboratory Network (ERLN) and to develop and validate analytical procedures. The primary objective of this study was to validate and verify the analytical procedures described in MS666 for analysis of carbamate pesticides in aqueous samples. The gathered data from this validation study will be used to: (1) demonstrate analytical method performance; (2) generate quality control acceptance criteria; and (3) revise the SOP to provide a validated method that would be available for use during a homeland security event. The data contained in this report will be compiled, by EPA CRL, with data generated by other EPA Regional laboratories so that performance metrics of Method EPA MS666 can be determined.

  17. SUMMARIES OF RESEARCH AND DEVELOPMENT ACTIVITIES PERFORMED IN RACINE R/I UNITS DURING THE 1966-67 SCHOOL YEAR. (TITLE SUPPLIED).

    ERIC Educational Resources Information Center

    QUILLING, MARY R.

    THE ACTIVITIES OF THE RACINE, WISCONSIN, R/I UNITS INCLUDED A CREATIVITY STUDY, LANGUAGE DEVELOPMENT EXPERIMENTS, TWO EXPERIMENTS IN INDIVIDUALIZING HANDWRITING, AN ANALYSIS OF THE EFFECTS OF INCREASED HOME-SCHOOL CONTACT ON PARENT ATTITUDE AND STUDENT ACHIEVEMENT, THREE EXPERIMENTS IN INDIVIDUALIZED ARITHMETIC INSTRUCTION, AND RESEARCH AND…

  18. Title IX: Boom or Bust?

    ERIC Educational Resources Information Center

    Mather, Marilyn J.

    2003-01-01

    Athletics has been significantly impacted by Title IX through an increase the number of female athletes, the number of teams available, and indirectly, the development of women's professional leagues. However, women in leadership positions in athletics have declined significantly since Title IX was signed into law. A concern about the…

  19. Seniority Rights and Title VII.

    ERIC Educational Resources Information Center

    McCarthy, Martha M.

    This chapter provides an analysis of seniority rights under Title VII of the Civil Rights Act of 1964, which bars discrimination in employment. Two legal theories have arisen in assessing Title VII claims: discriminatory treatment, in which the burden of proof of discriminatory intent lies with the plaintiff, and discriminatory impact of neutral…

  20. Sensitivity of GC-EI/MS, GC-EI/MS/MS, LC-ESI/MS/MS, LC-Ag(+) CIS/MS/MS, and GC-ESI/MS/MS for analysis of anabolic steroids in doping control.

    PubMed

    Cha, Eunju; Kim, Sohee; Kim, Ho Jun; Lee, Kang Mi; Kim, Ki Hun; Kwon, Oh-Seung; Lee, Jaeick

    2015-01-01

    This study compared the sensitivity of various separation and ionization methods, including gas chromatography with an electron ionization source (GC-EI), liquid chromatography with an electrospray ionization source (LC-ESI), and liquid chromatography with a silver ion coordination ion spray source (LC-Ag(+) CIS), coupled to a mass spectrometer (MS) for steroid analysis. Chromatographic conditions, mass spectrometric transitions, and ion source parameters were optimized. The majority of steroids in GC-EI/MS/MS and LC-Ag(+) CIS/MS/MS analysis showed higher sensitivities than those obtained with other analytical methods. The limits of detection (LODs) of 65 steroids by GC-EI/MS/MS, 68 steroids by LC-Ag(+) CIS/MS/MS, 56 steroids by GC-EI/MS, 54 steroids by LC-ESI/MS/MS, and 27 steroids by GC-ESI/MS/MS were below cut-off value of 2.0 ng/mL. LODs of steroids that formed protonated ions in LC-ESI/MS/MS analysis were all lower than the cut-off value. Several steroids such as unconjugated C3-hydroxyl with C17-hydroxyl structure showed higher sensitivities in GC-EI/MS/MS analysis relative to those obtained using the LC-based methods. The steroids containing 4, 9, 11-triene structures showed relatively poor sensitivities in GC-EI/MS and GC-ESI/MS/MS analysis. The results of this study provide information that may be useful for selecting suitable analytical methods for confirmatory analysis of steroids.

  1. Sensitivity of GC-EI/MS, GC-EI/MS/MS, LC-ESI/MS/MS, LC-Ag(+) CIS/MS/MS, and GC-ESI/MS/MS for analysis of anabolic steroids in doping control.

    PubMed

    Cha, Eunju; Kim, Sohee; Kim, Ho Jun; Lee, Kang Mi; Kim, Ki Hun; Kwon, Oh-Seung; Lee, Jaeick

    2015-01-01

    This study compared the sensitivity of various separation and ionization methods, including gas chromatography with an electron ionization source (GC-EI), liquid chromatography with an electrospray ionization source (LC-ESI), and liquid chromatography with a silver ion coordination ion spray source (LC-Ag(+) CIS), coupled to a mass spectrometer (MS) for steroid analysis. Chromatographic conditions, mass spectrometric transitions, and ion source parameters were optimized. The majority of steroids in GC-EI/MS/MS and LC-Ag(+) CIS/MS/MS analysis showed higher sensitivities than those obtained with other analytical methods. The limits of detection (LODs) of 65 steroids by GC-EI/MS/MS, 68 steroids by LC-Ag(+) CIS/MS/MS, 56 steroids by GC-EI/MS, 54 steroids by LC-ESI/MS/MS, and 27 steroids by GC-ESI/MS/MS were below cut-off value of 2.0 ng/mL. LODs of steroids that formed protonated ions in LC-ESI/MS/MS analysis were all lower than the cut-off value. Several steroids such as unconjugated C3-hydroxyl with C17-hydroxyl structure showed higher sensitivities in GC-EI/MS/MS analysis relative to those obtained using the LC-based methods. The steroids containing 4, 9, 11-triene structures showed relatively poor sensitivities in GC-EI/MS and GC-ESI/MS/MS analysis. The results of this study provide information that may be useful for selecting suitable analytical methods for confirmatory analysis of steroids. PMID:26489966

  2. Primary-Progressive MS (PPMS)

    MedlinePlus

    ... MS? Types of MS Primary progressive MS (PPMS) Primary progressive MS (PPMS) Share Smaller Text Larger Text Print In this article Overview PPMS is characterized by worsening neurologic function ( ...

  3. Student Aid and Postsecondary Tax Preferences. Limited Research Exists on Effectiveness of Tools to Assist Students and Families through Title IV Student Aid and Tax Preferences. Report to the Committee on Finance, U.S. Senate. GAO05-684

    ERIC Educational Resources Information Center

    Government Accountability Office, 2005

    2005-01-01

    Federal assistance helps students and families pay for postsecondary education through several policy tools--grant and loan programs authorized by title IV of the Higher Education Act of 1965 and more recently enacted tax preferences. In fiscal year 2004, about $14 billion in grants and $56 billion in loans were made under title IV while…

  4. 24 CFR 202.11 - Title I.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... INSTITUTIONS AND MORTGAGEES Title I and Title II Specific Requirements § 202.11 Title I. (a) Types of... under the Title I program. The administrative actions that may be applied are set forth in 24 CFR part 25. Civil money penalties may be imposed against Title I lenders and mortgagees pursuant to 24...

  5. 24 CFR 266.405 - Title.

    Code of Federal Regulations, 2010 CFR

    2005-04-01

    ... 24 Housing and Urban Development 2 2005-04-01 2005-04-01 false Title. 266.405 Section 266.405... Requirements; HUD Endorsement § 266.405 Title. (a) Eligibility of title. Marketable title to the mortgaged property must be vested in the mortgagor on the date the mortgage is filed for record. (b) Title...

  6. 24 CFR 266.405 - Title.

    Code of Federal Regulations, 2010 CFR

    2004-04-01

    ... 24 Housing and Urban Development 2 2004-04-01 2004-04-01 false Title. 266.405 Section 266.405... Requirements; HUD Endorsement § 266.405 Title. (a) Eligibility of title. Marketable title to the mortgaged property must be vested in the mortgagor on the date the mortgage is filed for record. (b) Title...

  7. 24 CFR 202.11 - Title I.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... in 24 CFR 25.5. Civil money penalties may be imposed against Title I lenders and mortgagees pursuant... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title I. 202.11 Section 202.11... INSTITUTIONS AND MORTGAGEES Title I and Title II Specific Requirements § 202.11 Title I. (a)...

  8. 24 CFR 266.405 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title. 266.405 Section 266.405... Requirements; HUD Endorsement § 266.405 Title. (a) Eligibility of title. Marketable title to the mortgaged property must be vested in the mortgagor on the date the mortgage is filed for record. (b) Title...

  9. 24 CFR 202.12 - Title II.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title II. 202.12 Section 202.12... INSTITUTIONS AND MORTGAGEES Title I and Title II Specific Requirements § 202.12 Title II. (a) Tiered pricing—(1... mortgagee approved for participation in Title II programs is notified by the Secretary that it had a rate...

  10. Ms. Mentor Unmasked

    ERIC Educational Resources Information Center

    Krebs, Paula

    2008-01-01

    This article presents an interview with Emily Toth, who writes the monthly "Ms. Mentor" academic advice column in the "Chronicle of Higher Education" and teaches in the English department at Louisiana State University, in Baton Rouge. She is the author of "Ms. Mentor's Impeccable Advice for Women in Academia" (1997), "Inside Peyton Place: The Life…

  11. 25 CFR 150.11 - Disclosure of land records, title documents, and title reports.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Disclosure of land records, title documents, and title... LAND RECORDS AND TITLE DOCUMENTS § 150.11 Disclosure of land records, title documents, and title reports. (a) The usefulness of a Land Titles and Records Office depends in large measure on the ability...

  12. MS/MS Automated Selected Ion Chromatograms

    2005-12-12

    This program can be used to read a LC-MS/MS data file from either a Finnigan ion trap mass spectrometer (.Raw file) or an Agilent Ion Trap mass spectrometer (.MGF and .CDF files) and create a selected ion chromatogram (SIC) for each of the parent ion masses chosen for fragmentation. The largest peak in each SIC is also identified, with reported statistics including peak elution time, height, area, and signal to noise ratio. It creates severalmore » output files, including a base peak intensity (BPI) chromatogram for the survey scan, a BPI for the fragmentation scans, an XML file containing the SIC data for each parent ion, and a "flat file" (ready for import into a database) containing summaries of the SIC data statistics.« less

  13. Improved Chiral Separation of Methamphetamine Enantiomers Using CSP-LC-MS-MS.

    PubMed

    Ward, Lauren F; Enders, Jeffrey R; Bell, David S; Cramer, Hugh M; Wallace, Frank N; McIntire, Gregory L

    2016-05-01

    To determine the true enantiomeric composition of methamphetamine urine drug testing results, chiral separation of dextro (D) and levo (L) enantiomers is necessary. While enantiomeric separation of methamphetamine has traditionally been accomplished using gas chromatography-mass spectrometry (GC-MS), chiral separation of D- and L-methamphetamine by chiral stationary phase (CSP) liquid chromatography-mass spectrometry/mass spectrometry (LC-MS-MS) has proved more reliable. Chirally selective detection of methamphetamine by GC-MS is often performed using L-N-trifluoroacetyl-prolyl chloride (TPC). L-TPC, a chiral compound, is known to have impurities that can affect the chiral composition percentages of the methamphetamine sample, potentially leading to inaccurate patient results. The comparative analysis of the samples run by GC and LC methods showed preferential bias of the GC method for producing error rates, consistent with previous research, of 8-19%. The CSP-LC-MS-MS method produces percent deviation errors of <2%. Additionally, the GC method failed to produce results that were 100% D- or L-isomer even for enantiomerically pure standards. A higher rate of D- and L-methamphetamine isomer racemization is seen in samples when analyzed by GC-MS using L-TPC-derivatizing agent. This racemization is not seen when these samples are tested with CSP-LC-MS-MS. Thus, a more accurate method of enantiomeric analysis is provided by CSP-LC-MS-MS. PMID:26869715

  14. NIF Title III engineering plan

    SciTech Connect

    Deis, G

    1998-06-01

    The purpose of this document is to define the work that must be accomplished by the NIF Project during Title III Engineering. This definition is intended to be sufficiently detailed to provide a framework for yearly planning, to clearly identify the specific deliverables so that the Project teams can focus on them, and to provide a common set of objectives and processes across the Project. This plan has been preceded by similar documents for Title I and Title II design and complements the Site Management Plan, the Project Control Manual, the Quality Assurance Program Plan, the RM Parsons NIF Title III Configuration Control Plan, the Integrated Project Schedule, the Preliminary Safety Analysis Report, the Configuration Management Plan, and the Transition Plan.

  15. Editor's Shelf: International Juvenile Titles.

    ERIC Educational Resources Information Center

    Mitchell-Powell, Brenda

    1994-01-01

    Provides an annotated list of international juvenile picture books and notes those that emphasize text over pictures. The 49 titles present international perspectives for educators, librarians, and parents seeking materials with alternative cultural content. The majority are folk tales. (SLD)

  16. Annotation of glycomics MS and MS/MS spectra using the GlycoWorkbench software tool.

    PubMed

    Damerell, David; Ceroni, Alessio; Maass, Kai; Ranzinger, René; Dell, Anne; Haslam, Stuart M

    2015-01-01

    The GlycoWorkbench software tool allows users to semiautomatically annotate glycomics MS and MS/MS spectra and MS glycoproteomics spectra. The GlycanBuilder software tool is embedded within GlycoWorkbench allowing users to draw glycan structures and export images of the drawn structures. This chapter demonstrates to users how to draw glycan structures within GlycoWorkbench using the GlycanBuilder software tool. This chapter also demonstrates how to use GlycoWorkbench to import MS and MS/MS glycomics spectra and use the cascading annotation feature to annotate both the MS and MS/MS spectra with a single command.

  17. SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer´s disease: appealing for ESI-IM-MS

    NASA Astrophysics Data System (ADS)

    Pujol-Pina, Rosa; Vilaprinyó-Pascual, Sílvia; Mazzucato, Roberta; Arcella, Annalisa; Vilaseca, Marta; Orozco, Modesto; Carulla, Natàlia

    2015-10-01

    The characterization of amyloid-beta peptide (Aβ) oligomer forms and structures is crucial to the advancement in the field of Alzheimer´s disease (AD). Here we report a critical evaluation of two methods used for this purpose, namely sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), extensively used in the field, and ion mobility coupled to electrospray ionization mass spectrometry (ESI-IM-MS), an emerging technique with great potential for oligomer characterization. To evaluate their performance, we first obtained pure cross-linked Aβ40 and Aβ42 oligomers of well-defined order. Analysis of these samples by SDS-PAGE revealed that SDS affects the oligomerization state of Aβ42 oligomers, thus providing flawed information on their order and distribution. In contrast, ESI-IM-MS provided accurate information, while also reported on the chemical nature and on the structure of the oligomers. Our findings have important implications as they challenge scientific paradigms in the AD field built upon SDS-PAGE characterization of Aβ oligomer samples.

  18. SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer´s disease: appealing for ESI-IM-MS

    PubMed Central

    Pujol-Pina, Rosa; Vilaprinyó-Pascual, Sílvia; Mazzucato, Roberta; Arcella, Annalisa; Vilaseca, Marta; Orozco, Modesto; Carulla, Natàlia

    2015-01-01

    The characterization of amyloid-beta peptide (Aβ) oligomer forms and structures is crucial to the advancement in the field of Alzheimer´s disease (AD). Here we report a critical evaluation of two methods used for this purpose, namely sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), extensively used in the field, and ion mobility coupled to electrospray ionization mass spectrometry (ESI-IM-MS), an emerging technique with great potential for oligomer characterization. To evaluate their performance, we first obtained pure cross-linked Aβ40 and Aβ42 oligomers of well-defined order. Analysis of these samples by SDS-PAGE revealed that SDS affects the oligomerization state of Aβ42 oligomers, thus providing flawed information on their order and distribution. In contrast, ESI-IM-MS provided accurate information, while also reported on the chemical nature and on the structure of the oligomers. Our findings have important implications as they challenge scientific paradigms in the AD field built upon SDS-PAGE characterization of Aβ oligomer samples. PMID:26450154

  19. Quantitative acylcarnitine determination by UHPLC-MS/MS--Going beyond tandem MS acylcarnitine "profiles".

    PubMed

    Minkler, Paul E; Stoll, Maria S K; Ingalls, Stephen T; Kerner, Janos; Hoppel, Charles L

    2015-12-01

    Tandem MS "profiling" of acylcarnitines and amino acids was conceived as a first-tier screening method, and its application to expanded newborn screening has been enormously successful. However, unlike amino acid screening (which uses amino acid analysis as its second-tier validation of screening results), acylcarnitine "profiling" also assumed the role of second-tier validation, due to the lack of a generally accepted second-tier acylcarnitine determination method. In this report, we present results from the application of our validated UHPLC-MS/MS second-tier method for the quantification of total carnitine, free carnitine, butyrobetaine, and acylcarnitines to patient samples with known diagnoses: malonic acidemia, short-chain acyl-CoA dehydrogenase deficiency (SCADD) or isobutyryl-CoA dehydrogenase deficiency (IBD), 3-methyl-crotonyl carboxylase deficiency (3-MCC) or ß-ketothiolase deficiency (BKT), and methylmalonic acidemia (MMA). We demonstrate the assay's ability to separate constitutional isomers and diastereomeric acylcarnitines and generate values with a high level of accuracy and precision. These capabilities are unavailable when using tandem MS "profiles". We also show examples of research interest, where separation of acylcarnitine species and accurate and precise acylcarnitine quantification is necessary.

  20. No latest title...

    THOMAS, 112th Congress

    Rep. Kaptur, Marcy [D-OH-9

    2011-01-18

    03/03/2011 Referred to the Subcommittee on Rural Development, Research, Biotechnology, and Foreign Agriculture. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  1. No latest title...

    THOMAS, 113th Congress

    Rep. Chabot, Steve [R-OH-1

    2013-06-14

    06/25/2013 Referred to the Subcommittee on Horticulture, Research, Biotechnology, and Foreign Agriculture. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  2. No latest title...

    THOMAS, 113th Congress

    Rep. Royce, Edward R. [R-CA-39

    2013-05-15

    05/22/2013 Referred to the Subcommittee on Horticulture, Research, Biotechnology, and Foreign Agriculture. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  3. No latest title...

    THOMAS, 112th Congress

    Rep. Fincher, Stephen Lee [R-TN-8

    2011-05-26

    06/08/2011 Referred to the Subcommittee on Rural Development, Research, Biotechnology, and Foreign Agriculture. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  4. No latest title...

    THOMAS, 112th Congress

    Rep. Bartlett, Roscoe G. [R-MD-6

    2011-01-05

    03/03/2011 Referred to the Subcommittee on Rural Development, Research, Biotechnology, and Foreign Agriculture. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  5. No latest title...

    THOMAS, 113th Congress

    Rep. Conyers, John, Jr. [D-MI-13

    2013-07-16

    08/13/2013 Referred to the Subcommittee on Horticulture, Research, Biotechnology, and Foreign Agriculture. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. No latest title...

    THOMAS, 113th Congress

    Rep. Ellison, Keith [D-MN-5

    2013-05-17

    06/03/2013 Referred to the Subcommittee on Horticulture, Research, Biotechnology, and Foreign Agriculture. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  7. No latest title...

    THOMAS, 113th Congress

    Rep. DelBene, Suzan K. [D-WA-1

    2013-04-25

    05/03/2013 Referred to the Subcommittee on Horticulture, Research, Biotechnology, and Foreign Agriculture. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  8. No latest title...

    THOMAS, 113th Congress

    Rep. Carson, Andre [D-IN-7

    2013-05-23

    06/03/2013 Referred to the Subcommittee on Horticulture, Research, Biotechnology, and Foreign Agriculture. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  9. No latest title...

    THOMAS, 112th Congress

    Rep. Kucinich, Dennis J. [D-OH-10

    2011-12-02

    12/19/2011 Referred to the Subcommittee on Rural Development, Research, Biotechnology, and Foreign Agriculture. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  10. On-line monitoring of volatile organic compounds at pptv levels by means of proton-transfer-reaction mass spectrometry (PTR-MS) medical applications, food control and environmental research

    NASA Astrophysics Data System (ADS)

    Lindinger, W.; Hansel, A.; Jordan, A.

    1998-02-01

    A proton transfer reaction mass spectrometer (PTR-MS) system has been developed which allows for on-line measurements of trace components with concentrations as low as a few pptv. The method is based on reactions of H3O+ ions, which perform non-dissociative proton transfer to most of the common volatile organic compounds (VOCs) but do not react with any of the components present in clean air. Medical applications by means of breath analysis allow for monitoring of metabolic processes in the human body, and examples of food research are discussed on the basis of VOC emissions from fruit, coffee and meat. Environmental applications include investigations of VOC emissions from decaying biomatter which have been found to be an important source for tropospheric acetone, methanol and ethanol. On-line monitoring of the diurnal variations of VOCs in the troposphere yield data demonstrating the present sensitivity of PTR-MS to be in the range of a few pptv. Finally, PTR-MS has proven to be an ideal tool to measure Henry's law constants and their dependencies on temperature as well as on the salt content of water.

  11. Managing Progressive MS

    MedlinePlus

    ... MS Society | 8 builders about renovations and home adaptations to support independence. OTs may also evaluate and ... Staying at home will mean making changes. Home adaptations do more than fight fatigue. They offer safety, ...

  12. Living with Advanced MS

    MedlinePlus

    ... Read More Read More Resource Edward M. Dowd Personal Advocate Program The Edward M. Dowd Personal Advocate ... Informed About the Society Vision Careers Leadership Cultural Values Financials News Press Room MS Prevalence Charitable Ratings ...

  13. IMS - MS Data Extractor

    SciTech Connect

    2015-10-20

    An automated drift time extraction and computed associated collision cross section software tool for small molecule analysis with ion mobility spectrometry-mass spectrometry (IMS-MS). The software automatically extracts drift times and computes associated collision cross sections for small molecules analyzed using ion mobility spectrometry-mass spectrometry (IMS-MS) based on a target list of expected ions provided by the user.

  14. Electrospray Ionization Tandem Mass Spectrometry (ESI-MS/MS)-Based Shotgun Lipidomics

    SciTech Connect

    Mezengie, Giorgis I.

    2011-01-11

    In the past decade, many new strategies for mass spectrometry (MS)-based analyses of lipids have been developed. Lipidomics is one of the most promising research fields to emerge as a result of these advances in MS. Currently, mass spectrometric analysis of lipids involves two complementary approaches: direct infusion (shotgun lipidomics) and liquid chromatography coupled to MS. In this chapter, I will demonstrate the approach of shotgun lipidomics using electrospray ionization tandem MS for the analysis of lipid molecular species directly from crude biological extracts of tissue or fluids.

  15. Reading Titles of Empirical Research Papers

    ERIC Educational Resources Information Center

    Labassi, Tahar

    2009-01-01

    The restricted time allocated to courses and the immediate need to read literature in English necessitates the teaching of selective reading in many English as a foreign language contexts. This paper reports on one element of an expeditious (quick, effective, efficient and selective) reading course for learners in an English for Academic Purposes…

  16. National Ignition Facility Title II Design Plan

    SciTech Connect

    Kumpan, S

    1997-03-01

    This National Ignition Facility (NIF) Title II Design Plan defines the work to be performed by the NIF Project Team between November 1996, when the U.S. Department of Energy (DOE) reviewed Title I design and authorized the initiation of Title H design and specific long-lead procurements, and September 1998, when Title 11 design will be completed.

  17. 48 CFR 1352.271-80 - Title.

    Code of Federal Regulations, 2010 CFR

    2012-10-01

    ... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1352.271-80 Title. As prescribed in 48 CFR 1371.111, insert the following clause: Title (APR 2010) (a) Title to all materials and... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Title. 1352.271-80...

  18. 13 CFR 314.7 - Title.

    Code of Federal Regulations, 2010 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Title. 314.7 Section 314.7... Property § 314.7 Title. (a) General. The Recipient must hold title to the Real Property required for a... and must maintain title at all times during the Estimated Useful Life of the Project, except in...

  19. 7 CFR § 3200.7 - Title.

    Code of Federal Regulations, 2010 CFR

    2016-01-01

    ... 7 Agriculture 15 2016-01-01 2016-01-01 false Title. § 3200.7 Section § 3200.7 Agriculture... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government....

  20. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2010 CFR

    1997-10-01

    ... 48 Federal Acquisition Regulations System 5 1997-10-01 1997-10-01 false Title. 1252.217-77 Section... Title. As prescribed at 1217.7000 (a) and (b), insert the following clause: Title (Oct 1994) (a) Unless otherwise provided, title to all materials and equipment to be incorporated in a vessel in the...

  1. 48 CFR 51.106 - Title.

    Code of Federal Regulations, 2010 CFR

    1999-10-01

    ... 48 Federal Acquisition Regulations System 1 1999-10-01 1999-10-01 false Title. 51.106 Section 51... CONTRACTORS Contractor Use of Government Supply Sources 51.106 Title. (a) Title to all property acquired by..., title to property having an acquisition cost of less than $5,000 shall vest in the contractor...

  2. 48 CFR 1832.1009 - Title.

    Code of Federal Regulations, 2010 CFR

    1998-10-01

    ... 48 Federal Acquisition Regulations System 6 1998-10-01 1998-10-01 false Title. 1832.1009 Section... Title. In accordance with 42 U.S.C. 2465d, NASA shall not take title to launch vehicles under contracts... eliminate NASA's right to take title to other property acquired or produced by the contractor under...

  3. 48 CFR 252.217-7006 - Title.

    Code of Federal Regulations, 2010 CFR

    2008-10-01

    ... 48 Federal Acquisition Regulations System 3 2008-10-01 2008-10-01 false Title. 252.217-7006... Clauses 252.217-7006 Title. As prescribed in 217.7104(a), use the following clause: Title (DEC 1991) (a) Unless otherwise provided, title to all materials and equipment to be incorporated in a vessel in...

  4. 7 CFR 3200.7 - Title.

    Code of Federal Regulations, 2010 CFR

    2009-01-01

    ... 7 Agriculture 15 2009-01-01 2009-01-01 false Title. 3200.7 Section 3200.7 Agriculture Regulations... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government....

  5. 48 CFR 245.7309-5 - Title.

    Code of Federal Regulations, 2010 CFR

    2008-10-01

    ... 48 Federal Acquisition Regulations System 3 2008-10-01 2008-10-01 false Title. 245.7309-5 Section... Title. (a) Unless otherwise specified in the Invitation, title to property sold under this Invitation... Contractor, title shall not vest until payment and loading are completed. (b) A Standard Form 97,...

  6. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2010 CFR

    1998-10-01

    ... 48 Federal Acquisition Regulations System 5 1998-10-01 1998-10-01 false Title. 1252.217-77 Section... Title. As prescribed at 1217.7000 (a) and (b), insert the following clause: Title (OCT 1994) (a) Unless otherwise provided, title to all materials and equipment to be incorporated in a vessel in the...

  7. 48 CFR 1352.217-97 - Title.

    Code of Federal Regulations, 2010 CFR

    1997-10-01

    ... 48 Federal Acquisition Regulations System 5 1997-10-01 1997-10-01 false Title. 1352.217-97 Section... Clauses 1352.217-97 Title. As prescribed in 1317.7001(a), insert the following clause: Title (CAR 1352.217-97 ) (Jan 1987) Unless title to materials and equipment acquired or produced for, or allocated...

  8. 48 CFR 1352.217-97 - Title.

    Code of Federal Regulations, 2010 CFR

    2009-10-01

    ... 48 Federal Acquisition Regulations System 5 2009-10-01 2009-10-01 false Title. 1352.217-97 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 1352.217-97 Title. As prescribed in 1317.7001(a), insert the following clause: Title (CAR 1352.217-97) (JAN 1987) Unless title...

  9. 7 CFR 3200.7 - Title.

    Code of Federal Regulations, 2010 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Title. 3200.7 Section 3200.7 Agriculture Regulations... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government....

  10. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2010 CFR

    2005-04-01

    ... 24 Housing and Urban Development 2 2005-04-01 2005-04-01 false Title. 200.61 Section 200.61... Requirements for Existing Projects General Requirements § 200.61 Title. (a) Marketable title to the project must be vested in the mortgagor as of the date the mortgage is filed for record. (b) Title evidence...

  11. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2010 CFR

    2004-04-01

    ... 24 Housing and Urban Development 2 2004-04-01 2004-04-01 false Title. 200.61 Section 200.61... Requirements for Existing Projects General Requirements § 200.61 Title. (a) Marketable title to the project must be vested in the mortgagor as of the date the mortgage is filed for record. (b) Title evidence...

  12. 48 CFR 1352.217-97 - Title.

    Code of Federal Regulations, 2010 CFR

    2001-10-01

    ... 48 Federal Acquisition Regulations System 5 2001-10-01 2001-10-01 false Title. 1352.217-97 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 1352.217-97 Title. As prescribed in 1317.7001(a), insert the following clause: Title (CAR 1352.217-97) (JAN 1987) Unless title...

  13. 48 CFR 1352.217-97 - Title.

    Code of Federal Regulations, 2010 CFR

    1998-10-01

    ... 48 Federal Acquisition Regulations System 5 1998-10-01 1998-10-01 false Title. 1352.217-97 Section... Clauses 1352.217-97 Title. As prescribed in 1317.7001(a), insert the following clause: Title (CAR 1352.217-97) (JAN 1987) Unless title to materials and equipment acquired or produced for, or allocated to,...

  14. 7 CFR 3200.7 - Title.

    Code of Federal Regulations, 2010 CFR

    2000-01-01

    ... 7 Agriculture 15 2000-01-01 2000-01-01 false Title. 3200.7 Section 3200.7 Agriculture Regulations... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government....

  15. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2010 CFR

    2007-10-01

    ... of Provisions and Clauses 1252.217-77 Title. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (OCT 1994) (a) Unless otherwise provided, title to all materials and... 48 Federal Acquisition Regulations System 5 2007-10-01 2007-10-01 false Title. 1252.217-77...

  16. 48 CFR 1352.217-97 - Title.

    Code of Federal Regulations, 2010 CFR

    2007-10-01

    ... 48 Federal Acquisition Regulations System 5 2007-10-01 2007-10-01 false Title. 1352.217-97 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 1352.217-97 Title. As prescribed in 1317.7001(a), insert the following clause: Title (CAR 1352.217-97) (JAN 1987) Unless title...

  17. 7 CFR 3200.7 - Title.

    Code of Federal Regulations, 2010 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Title. 3200.7 Section 3200.7 Agriculture Regulations... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government....

  18. 48 CFR 1352.217-97 - Title.

    Code of Federal Regulations, 2010 CFR

    2005-10-01

    ... 48 Federal Acquisition Regulations System 5 2005-10-01 2005-10-01 false Title. 1352.217-97 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 1352.217-97 Title. As prescribed in 1317.7001(a), insert the following clause: Title (CAR 1352.217-97) (JAN 1987) Unless title...

  19. 48 CFR 1352.271-80 - Title.

    Code of Federal Regulations, 2010 CFR

    2015-10-01

    ... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1352.271-80 Title. As prescribed in 48 CFR 1371.111, insert the following clause: Title (APR 2010) (a) Title to all materials and... 48 Federal Acquisition Regulations System 5 2015-10-01 2015-10-01 false Title. 1352.271-80...

  20. Preference Scaling of Titles in English Composition.

    ERIC Educational Resources Information Center

    Jackson, Lorraine Morlock

    1968-01-01

    To learn what essay titles appealed to seventh grade students, 40 female and 52 male California students rated each of 100 essay titles according to their interest in writing a composition based on that title. Also, the study was designed to contrast the title preferences of male, female, intellectually-bright, and intellectually-dull subgroups…

  1. 48 CFR 252.217-7006 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Title. 252.217-7006... Clauses 252.217-7006 Title. As prescribed in 217.7104(a), use the following clause: Title (DEC 1991) (a) Unless otherwise provided, title to all materials and equipment to be incorporated in a vessel in...

  2. 24 CFR 232.600 - Title evidence.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title evidence. 232.600 Section 232... Equipment Title § 232.600 Title evidence. The lender, without expense to the Commissioner, shall furnish to the Commissioner a policy of title insurance, or if the lender is unable to furnish a policy...

  3. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title. 200.61 Section 200.61... Requirements for Existing Projects General Requirements § 200.61 Title. (a) Marketable title to the project must be vested in the mortgagor as of the date the mortgage is filed for record. (b) Title evidence...

  4. 48 CFR 245.7309-5 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Title. 245.7309-5 Section... Title. (a) Unless otherwise specified in the Invitation, title to property sold under this Invitation... Contractor, title shall not vest until payment and loading are completed. (b) A Standard Form 97,...

  5. 7 CFR 3200.7 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Title. 3200.7 Section 3200.7 Agriculture Regulations... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government....

  6. 12 CFR 5.42 - Corporate title.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Corporate title. 5.42 Section 5.42 Banks and... CORPORATE ACTIVITIES Other Changes in Activities and Operations § 5.42 Corporate title. (a) Authority. 12 U... change its corporate title. (c) Standards. A national bank may change its corporate title provided...

  7. 48 CFR 1352.271-80 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1352.271-80 Title. As prescribed in 48 CFR 1371.111, insert the following clause: Title (APR 2010) (a) Title to all materials and... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Title. 1352.271-80...

  8. 13 CFR 314.7 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Title. 314.7 Section 314.7... Property § 314.7 Title. (a) General. The Recipient must hold title to the Real Property required for a... and must maintain title at all times during the Estimated Useful Life of the Project, except in...

  9. 24 CFR 241.600 - Title evidence.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title evidence. 241.600 Section 241... Meters in Multifamily Projects Without a HUD-Insured or HUD-Held Mortgage Title § 241.600 Title evidence... to the Commissioner, and a policy of title insurance as provided in paragraph (a)(1) of this...

  10. 48 CFR 51.106 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Title. 51.106 Section 51... GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Government Supply Sources 51.106 Title. (a) Title to all... educational institutions and the Government Property clause at 52.245-1, Alternate II, is used, title...

  11. Titles are terrific: creating titles that will attract attention.

    PubMed

    Baum, Neil

    2014-01-01

    There are millions of blogs posted every day. However, the majority of them don't get read. Often this is because the title is not engaging and does not motivate the reader to read the content of the blog. Your blog content has to be informative and engaging, but first the blog must have a title that makes the reader want to take the time to read the blog. This article will discuss techniques and methods to use to create engaging titles that will get your blog read and, more importantly, move the reader from the blog to your Web site, and then to go online and make an appointment with your practice. PMID:25807616

  12. Implementation of Title V in California

    SciTech Connect

    Werner, B.; Cook, B.

    1996-12-31

    This presentation provides information on California`s Title V operating permit programs for stationary sources mandated by the 1990 Clean Air Act amendments. It covers background, applicability, regulatory history, requirements, and issues. In addition, specific information is provided on the progress of Title V implementation in California, including: the roles of implementing agencies, the status of district Title V programs, number and distribution of Title V sources, cost of Title V implementation, and highlights of Title V implementation in the State. The question and answer format is intended to facilitate easy access to specific information related to the Title V operating permit programs in California.

  13. Progressive-Relapsing MS (PRMS)

    MedlinePlus

    ... the disease process in MS and in MRI technology. Individuals who were previously diagnosed with progressive-relapsing MS would now be ... The National MS Society is Here to Help Need More Information? We ...

  14. Research on the change of chemical composition in productive process of Re Du Ning injection by HPLC/Q-TOF MS.

    PubMed

    Zhang, Shan; Li, Yan-Jing; Zhang, Chun-Xiao; Huang, Wen-Zhe; Ding, Gang; Wang, Zhen-Zhong; Bi, Yu-An; Xiao, Wei

    2016-02-01

    A high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF MS) was developed for the analysis of chemical composition change in the production process of Re Du Ning injection, a Chinese medicine preparation with a combination of Lonicera japonica Thunb., Gardenia jasminoides Ellis and Artemisia annua L. A total of 90 compounds from raw materials-intermediates-Re Du Ning injection were detected; among them, 55 compounds were identified or tentatively characterized, and the characteristic ions of different types of compounds were described. Based on these studies, the different types of compounds in the various process routes were analyzed. A total of 28 compounds, including seven iridoid glycosides and six monoterpenes from G. jasminoides Ellis, five iridoid glycosides, nine phenolic acids and one unknown compound from L. japonica Thunb., were transferred to Re Du Ning injection, and two unknown compounds were generated in the production process of Re Du Ning injection. The results indicated that the Chinese Medicine Pharmaceutical process control is very important. This method could provide some reference for other Chinese medicine preparations.

  15. Research on the change of chemical composition in productive process of Re Du Ning injection by HPLC/Q-TOF MS.

    PubMed

    Zhang, Shan; Li, Yan-Jing; Zhang, Chun-Xiao; Huang, Wen-Zhe; Ding, Gang; Wang, Zhen-Zhong; Bi, Yu-An; Xiao, Wei

    2016-02-01

    A high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF MS) was developed for the analysis of chemical composition change in the production process of Re Du Ning injection, a Chinese medicine preparation with a combination of Lonicera japonica Thunb., Gardenia jasminoides Ellis and Artemisia annua L. A total of 90 compounds from raw materials-intermediates-Re Du Ning injection were detected; among them, 55 compounds were identified or tentatively characterized, and the characteristic ions of different types of compounds were described. Based on these studies, the different types of compounds in the various process routes were analyzed. A total of 28 compounds, including seven iridoid glycosides and six monoterpenes from G. jasminoides Ellis, five iridoid glycosides, nine phenolic acids and one unknown compound from L. japonica Thunb., were transferred to Re Du Ning injection, and two unknown compounds were generated in the production process of Re Du Ning injection. The results indicated that the Chinese Medicine Pharmaceutical process control is very important. This method could provide some reference for other Chinese medicine preparations. PMID:26058547

  16. Comparative and Contrastive Observations on Scientific Titles Written in English and Spanish

    ERIC Educational Resources Information Center

    Soler, Viviana

    2011-01-01

    This research focuses on the structural construction of scientific titles in English and Spanish in research papers (RP) and review papers (RVP) in the biological and social sciences. The questions raised were (i) whether structural construction is a key distinctive feature between RP and RVP titles; (ii) whether the inherent peculiarities of…

  17. The Effectiveness of Title I: Synthesis of National-Level Evidence from 1966 to 2013

    ERIC Educational Resources Information Center

    Sousa, Sonia; Armor, David

    2016-01-01

    This paper reviews prior research to assess the effectiveness of Title I in closing the achievement gaps of disadvantaged students vis-à-vis their non-disadvantaged counterparts. A research synthesis approach is adopted to summarize national assessments of Title I conducted between 1966 and 2011. These analyses are supplemented by the authors'…

  18. Analysis of Phosphonic Acids: Validation of Semi-Volatile Analysis by HPLC-MS/MS by EPA Method MS999

    SciTech Connect

    Owens, J; Vu, A; Koester, C

    2008-10-31

    The Environmental Protection Agency's (EPA) Region 5 Chicago Regional Laboratory (CRL) developed a method titled Analysis of Diisopropyl Methylphosphonate, Ethyl Hydrogen Dimethylamidophosphate, Isopropyl Methylphosphonic Acid, Methylphosphonic Acid, and Pinacolyl Methylphosphonic Acid in Water by Multiple Reaction Monitoring Liquid Chromatography/Tandem Mass Spectrometry: EPA Version MS999. This draft standard operating procedure (SOP) was distributed to multiple EPA laboratories and to Lawrence Livermore National Laboratory, which was tasked to serve as a reference laboratory for EPA's Environmental Reference Laboratory Network (ERLN) and to develop and validate analytical procedures. The primary objective of this study was to validate and verify the analytical procedures described in EPA Method MS999 for analysis of the listed phosphonic acids and surrogates in aqueous samples. The gathered data from this validation study will be used to: (1) demonstrate analytical method performance; (2) generate quality control acceptance criteria; and (3) revise the SOP to provide a validated method that would be available for use during a homeland security event. The data contained in this report will be compiled, by EPA CRL, with data generated by other EPA Regional laboratories so that performance metrics of EPA Method MS999 can be determined.

  19. Title III Policy: State of the States. ESEA Evaluation Brief: The English Language Acquisition, Language Enhancement, and Academic Achievement Act

    ERIC Educational Resources Information Center

    Ramsey, Andrea; O'Day, Jennifer

    2010-01-01

    "Title III Policy: State of the States" (2010) discusses state implementation of the Title III accountability requirements based on phone interviews with six state Title III Directors in the spring of 2009, interviews with six experts and university-based researchers who work on education for English Learners, and based on earlier data collected…

  20. New Help for MS Patients

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Mark VII MicroClimate Medical Personal Cooling system enables multiple sclerosis' victims, as well as cerebral palsy, spinabifida patients and others to lower their body temperatures. Although this is not a cure, cooling can produce a dramatic improvement in symptoms. The Multiple Sclerosis Association of America has placed cool suits in MS research care centers. This technology originated in the need for cooling systems in spa@esuits. "Cool Suits" are now used by hazardous materials workers, armored vehicle crews, firefighters and crop dusters. A surgical personal cooling system has also been developed for medical personnel working in hot operating room environments.

  1. Facing Title V permit constraints

    SciTech Connect

    Patankar, U.M.

    1995-06-01

    The new Title V operating permit requirement under state regulations pursuant to the 1990 Clean Air Act Amendments will cover every emission source at a facility. These rules will significantly affect an operation by setting minimum compliance requirements, mandating periodic compliance certification, prescribing complex monitoring, record keeping and reporting procedures and making state and EPA approval of routine operational changes necessary through a permit amendment. The main concern with Title V is its effect on the operational flexibility of a facility, and individual emission sources within that facility. Unless properly addressed in a permit document, the term operational flexibility, so freely used by regulators in the context of the Title V program, can turn into a misnomer and the ability to operate as before may be significantly compromised under Title V. True operational flexibility is essential for businesses to respond to real changes in the marketplace. In the age of automation, just-in-time inventories and increased competition, flexibility to operate can mean the difference between growth and stagnation.

  2. Louisiana Title V General Permits

    SciTech Connect

    Boyer, B.E.; Neal, T.L.

    1995-12-31

    Title V of the Federal Clean Air Act Amendments of 1990 requires federal operating permits for all major sources of air pollution. In 1992, Title 40, Part 70 of the Code of Federal Regulations (40 CFR Part 70) codified the law s requirements. These federal regulations, entitled Operating Permit Program, define the minimum requirements for state administered operating permit programs. The intent of Title V is to put into one document all requirements of an operating permit. General Permits for oil and gas facilities may be preferred if the facility can comply with all permit requirements. If greater flexibility than allowed by the General Permit is required, then the facility should apply for an individual Title V permit. General Permits are designed to streamline the permitting process, shorten the time it takes to obtain approval for initial and modified permits. The advantages of the General Permit include reduced paperwork and greater consistency because the permits are standardized. There should be less uncertainty because permit requirements will be known at the time of application. Approval times for Initial and modified General Permits should be reduced. Lengthy public notice procedures (and possible hearings) will be required for only the initial approval of the General Permit and not for each applicant to the permit. A disadvantage of General Permits is reduced flexibility since the facility must comply with the requirements of a standardized permit.

  3. Title III hazardous air pollutants

    SciTech Connect

    Todd, R.

    1995-12-31

    The author presents an overview of the key provisions of Title III of the Clean Air Act Amendments of 1990. The key provisions include the following: 112(b) -- 189 Hazardous Air Pollutants (HAP); 112(a) -- Major Source: 10 TPY/25 TPY; 112(d) -- Application of MACT; 112(g) -- Modifications; 112(I) -- State Program; 112(j) -- The Hammer; and 112(r) -- Accidental Release Provisions.

  4. Title IX--Its Impact.

    ERIC Educational Resources Information Center

    Gerou, Nancy

    Fear, judgements, and violence have characterized discrimination throughout history. In sex discrimination, both sexes have a responsibility to fight discriminatory attitudes. Women should retain their distinctly feminine characteristics while at the same time being provided the same opportunities as men of equal ability. Title IX of the Education…

  5. Title I and the Arts.

    ERIC Educational Resources Information Center

    Le Tendre, Mary Jean

    1997-01-01

    Argues that although improving academic achievement is the crux of Title I, the arts can contribute to enhancing academic achievement in at-risk students. An example of this approach is provided via partnership between the John F. Kennedy Center for the Performing Arts and Washington (DC) metropolitan school districts. (GR)

  6. ICP-MS Workshop

    SciTech Connect

    Carman, April J.; Eiden, Gregory C.

    2014-11-01

    This is a short document that explains the materials that will be transmitted to LLNL and DNN HQ regarding the ICP-MS Workshop held at PNNL June 17-19th. The goal of the information is to pass on to LLNL information regarding the planning and preparations for the Workshop at PNNL in preparation of the SIMS workshop at LLNL.

  7. Titles--Who Needs Them?

    ERIC Educational Resources Information Center

    McAteer, John F.

    1974-01-01

    This article examines the question of student over-familiarity with student teachers, especially in the practice of addressing student teachers by a proper name without benefit of the prefix "Mr.,""Mrs.,""Miss," or even "Ms." (Author/JA)

  8. What the Research Says about Class Size, Professional Development, and Recruitment, Induction, and Retention of Highly Qualified Teachers: A Compendium of the Evidence on Title II, Part A, Program-Funded Strategies

    ERIC Educational Resources Information Center

    Krasnoff, Basha

    2015-01-01

    States and districts have the flexibility to creatively use Title II, Part A funds to address teacher quality issues. Currently, three strategies predominate--class size reduction, professional development, and recruitment, induction, and retention of highly qualified teachers. Each strategy is implemented with the intention of improving teaching…

  9. Negotiating Title V and non-Title V permits

    SciTech Connect

    Erbes, R.E.; MacDougall, C.R.

    1998-12-31

    The Title V Operating Permits program has been extended over many more years than originally anticipated when the 1990 Clean Air Act Amendments were first legislated. In fact, the regulatory program is still being refined even as facilities complete and submit their Title V permit applications. Likewise, it is clear that the agency review of the Title V permit applications will probably take considerably longer than originally anticipated. Finally, when the agency does complete the review, it is equally clear that there will need to be a significant amount of negotiating on the part of the facility to arrive at a simplified permit that is operationally feasible. This paper presents a number of suggestions for what the facility should be doing between the time the permit application is first submitted and the agency responds with a draft permit. The suggestions are designed to help simplify the permit and enhance flexibility. In addition, the paper presents permit negotiating techniques and points out the pitfalls that will be encountered if the facility does not take action prior to receiving the draft Title V permit. This paper suggests that the facility should internally evaluate how the permit application impacts facility operations prior to the agency doing so. It also suggests that the facility should contact the agency early and amend the permit application to take advantage of increasing regulatory flexibility. By taking these steps, and properly negotiating the permit terms and conditions; the facility will achieve a much better permit, and will hopefully be able to avoid the regulatory burdens and delays associated with re-opening the permit during the next 5 to 8 years (from the time of permit application submittal).

  10. Impacts of Title IV in Maryland

    SciTech Connect

    Sherwell, J.; Ellis, H.; Corio, L.; Seinfelt, J.

    1995-12-31

    The Maryland Department of Natural Resources` Power Plant Research Program has evaluated the environmental effects of acid deposition on Maryland`s air, land, water (especially the Chesapeake Bay), and human resources since the mid-1980`s. Title IV of the Clean Air Act Amendments of 1990 (CAAA90) has focused much attention on the mandated reductions of nitrogen oxides (NO{sub x}) and sulfur dioxide (SO{sub 2}) to control acid deposition. Baseline data on acidic deposition and air emissions/pollution control for NO{sub x} and SO{sub 2} acquired through PPRP studies have proved useful in evaluating the impacts of Title IV on Maryland power plants and resources. Three example programs are discussed: The first is an evaluation of SO{sub 2} emissions on ecosystems through the use of critical loads--the amount of acid rain that an ecosystem can tolerate without continuing to acidify. Results support the use of broadly based emissions trading scenarios: The second study is an evaluation of the potential for reducing nitrate loading in the Chesapeake Bay by reducing NO{sub x} emissions. Results indicate substantial NO{sub x} emission reductions could offer significant reductions in nitrate deposition to the Bay: The final study is a review of the impacts of Title IV on the Maryland coal industry and the prospects for coal cleaning and advanced combustion technologies. Current results indicate that Maryland coal will meet Phase 2 SO{sub 2} emission standards using advanced combustion techniques, such as fluidized bed technologies, but that additional emissions controls, such as a scrubber would be required in a conventional boiler.

  11. NAPS-MS

    PubMed Central

    Gudesblatt, Mark; Kresa-Reahl, Kiren; Brandes, David W.; Sater, Pamela

    2016-01-01

    Background: Patients with multiple sclerosis (MS) have higher rates of fatigue, mood disturbance, and cognitive impairments than healthy populations. Disease-modifying agents may affect sleep. Although patients taking natalizumab often show improvement in fatigue during the first year of therapy, the mechanism behind this effect is unknown. The aim of the NAPS-MS study was to investigate whether natalizumab affected objective measures of sleep as determined by polysomnography (PSG) and multiple sleep latency testing (MSLT) in patients with MS with fatigue or sleepiness initiating therapy. Additional goals were to evaluate changes in measures of fatigue, mood, and cognition and to correlate these measures with objective sleep measures. Methods: Patients underwent PSG and MSLT before their first natalizumab infusion and after their seventh. Patients completed the Modified Fatigue Impact Scale, Fatigue Severity Scale (FSS), Epworth Sleepiness Scale (ESS), and visual analogue scale for fatigue (VAS-F) at their first, fourth, and seventh natalizumab infusions. NeuroTrax cognitive tests and the Hospital Anxiety and Depression Scale (HADS) were performed at the first and seventh natalizumab infusions. Results: Changes in sleep efficiency, wakefulness after sleep onset, and multiple sleep latency from baseline to 6 months of therapy did not reach significance. The FSS, VAS-F, ESS, and HADS scores were significantly improved after 6 months of therapy; cognitive scores were not significantly improved. Conclusions: Although treatment with natalizumab was associated with improvements in fatigue, sleepiness, and mood, changes in objective measures of sleep were not significant. PMID:27551242

  12. Parent Power and Title I ESEA.

    ERIC Educational Resources Information Center

    National Urban League, Inc., New York, NY.

    This pamphlet is designed to inform the parents of disadvantaged elementary and secondary school students of the provisions of ESEA Title I, and of the possible abuses of Title I funds which might otherwise be allocated to the direct improvement of their children's education. Its contents include: parents' guide to ESEA Title I: what it is and…

  13. Title I, Higher Education Act Program Abstracts.

    ERIC Educational Resources Information Center

    Miller, Lorna M., Ed.

    The 1979 edition of the Title I, Higher Education Act Program Abstracts is presented. Directed toward state Title I, HEA administrators, the program abstracts are made available in order to encourage nationwide program replication of those tested and evaluated programs that have been conducted with Title I support by institutions of higher…

  14. 12 CFR 543.1 - Corporate title.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-INCORPORATION, ORGANIZATION, AND CONVERSION § 543.1 Corporate title. (a) General. A Federal savings association...) Title change. Prior to changing its corporate title, an association must file with the OTS a written notice indicating the intended change. The OTS, shall provide to the association a timely...

  15. 43 CFR 4.307 - Title.

    Code of Federal Regulations, 2010 CFR

    2000-10-01

    ... 43 Public Lands: Interior 1 2000-10-01 2000-10-01 false Title. 4.307 Section 4.307 Public Lands... Title. Upon payment by the tribe of the interests purchased, the Superintendent shall issue a... an order that the United States holds title to such interests in trust for the tribe, lodge...

  16. 7 CFR 2812.6 - Title.

    Code of Federal Regulations, 2010 CFR

    2000-01-01

    ... 7 Agriculture 15 2000-01-01 2000-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture-(Continued) OFFICE OF OPERATIONS,DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will...

  17. 48 CFR 1371.111 - Title.

    Code of Federal Regulations, 2010 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Title. 1371.111 Section... REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP REPAIR Provisions and Clauses 1371.111 Title. Insert clause 1352.271-80, Title, in all solicitations and contracts for ship repair....

  18. 7 CFR § 3203.7 - Title.

    Code of Federal Regulations, 2010 CFR

    2016-01-01

    ... 7 Agriculture 15 2016-01-01 2016-01-01 false Title. § 3203.7 Section § 3203.7 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF PROCUREMENT AND PROPERTY MANAGEMENT... PURSUANT TO SECTION 14220 OF THE 2008 FARM BILL § 3203.7 Title. Title of ownership to excess computers...

  19. 7 CFR 2812.6 - Title.

    Code of Federal Regulations, 2010 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS, DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will...

  20. 48 CFR 1832.1009 - Title.

    Code of Federal Regulations, 2010 CFR

    2006-10-01

    ... 48 Federal Acquisition Regulations System 6 2006-10-01 2006-10-01 false Title. 1832.1009 Section... CONTRACTING REQUIREMENTS CONTRACT FINANCING Performance-Based Payments 1832.1009 Title. In accordance with 42 U.S.C. 2465d, NASA shall not take title to launch vehicles under contracts for launch...

  1. 48 CFR 32.1009 - Title.

    Code of Federal Regulations, 2010 CFR

    2015-10-01

    ... 48 Federal Acquisition Regulations System 1 2015-10-01 2015-10-01 false Title. 32.1009 Section 32... REQUIREMENTS CONTRACT FINANCING Performance-Based Payments 32.1009 Title. (a) Since the clause at 52.232-32, Performance-Based Payments, gives the Government title to the property described in paragraph (f) of...

  2. 43 CFR 4.307 - Title.

    Code of Federal Regulations, 2010 CFR

    2004-10-01

    ... 43 Public Lands: Interior 1 2004-10-01 2004-10-01 false Title. 4.307 Section 4.307 Public Lands... Title. Upon payment by the tribe of the interests purchased, the Superintendent must issue a certificate... the United States holds title to such interests in trust for the tribe, lodge the complete...

  3. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2010 CFR

    2001-10-01

    ... 48 Federal Acquisition Regulations System 5 2001-10-01 2001-10-01 false Title. 1252.217-77 Section... REQUIREMENTS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 1252.217-77 Title. As prescribed at 1217.7000 (a) and (b), insert the following clause: Title (OCT 1994) (a) Unless...

  4. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2010 CFR

    2009-10-01

    ... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-77 Title. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (OCT 1994) (a) Unless otherwise... 48 Federal Acquisition Regulations System 5 2009-10-01 2009-10-01 false Title. 1252.217-77...

  5. 7 CFR 2812.6 - Title.

    Code of Federal Regulations, 2010 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS, DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will...

  6. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2010 CFR

    2005-10-01

    ... SOLICITATIONS PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-77 Title. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (Oct 1994) (a) Unless otherwise... 48 Federal Acquisition Regulations System 5 2005-10-01 2005-10-01 false Title. 1252.217-77...

  7. 7 CFR 3203.7 - Title.

    Code of Federal Regulations, 2010 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Title. 3203.7 Section 3203.7 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF PROCUREMENT AND PROPERTY MANAGEMENT... PURSUANT TO SECTION 14220 OF THE 2008 FARM BILL § 3203.7 Title. Title of ownership to excess computers...

  8. 43 CFR 4.307 - Title.

    Code of Federal Regulations, 2010 CFR

    2008-10-01

    ... 43 Public Lands: Interior 1 2008-10-01 2008-10-01 false Title. 4.307 Section 4.307 Public Lands... Title. (a) Upon payment by the tribe of the interests purchased, the Superintendent must: (1) Issue a... or Indian probate judge will: (1) Issue an order that the United States holds title to the...

  9. 43 CFR 4.307 - Title.

    Code of Federal Regulations, 2010 CFR

    2001-10-01

    ... 43 Public Lands: Interior 1 2001-10-01 2001-10-01 false Title. 4.307 Section 4.307 Public Lands... Title. Upon payment by the tribe of the interests purchased, the Superintendent shall issue a... an order that the United States holds title to such interests in trust for the tribe, lodge...

  10. 7 CFR 2812.6 - Title.

    Code of Federal Regulations, 2010 CFR

    2009-01-01

    ... 7 Agriculture 15 2009-01-01 2009-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS,DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will...

  11. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2010 CFR

    2012-10-01

    ... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-77 Title. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (OCT 1994) (a) Unless otherwise... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Title. 1252.217-77...

  12. 7 CFR § 2812.6 - Title.

    Code of Federal Regulations, 2010 CFR

    2016-01-01

    ... 7 Agriculture 15 2016-01-01 2016-01-01 false Title. § 2812.6 Section § 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS, DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will...

  13. 48 CFR 1832.1009 - Title.

    Code of Federal Regulations, 2010 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Title. 1832.1009 Section... CONTRACTING REQUIREMENTS CONTRACT FINANCING Performance-Based Payments 1832.1009 Title. In accordance with 42 U.S.C. 2465d, NASA shall not take title to launch vehicles under contracts for launch...

  14. 48 CFR 32.1009 - Title.

    Code of Federal Regulations, 2010 CFR

    1999-10-01

    ... 48 Federal Acquisition Regulations System 1 1999-10-01 1999-10-01 false Title. 32.1009 Section 32... Performance-Based Payments 32.1009 Title. (a) Since the clause at 52.232-32, Performance-Based Payments, gives the Government title to the property described in paragraph (f) of the clause, the contracting...

  15. 48 CFR 1371.111 - Title.

    Code of Federal Regulations, 2010 CFR

    2015-10-01

    ... 48 Federal Acquisition Regulations System 5 2015-10-01 2015-10-01 false Title. 1371.111 Section... REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP REPAIR Provisions and Clauses 1371.111 Title. Insert clause 1352.271-80, Title, in all solicitations and contracts for ship repair....

  16. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2010 CFR

    2015-10-01

    ... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-77 Title. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (OCT 1994) (a) Unless otherwise... 48 Federal Acquisition Regulations System 5 2015-10-01 2015-10-01 false Title. 1252.217-77...

  17. 48 CFR 1832.1009 - Title.

    Code of Federal Regulations, 2010 CFR

    2015-10-01

    ... 48 Federal Acquisition Regulations System 6 2015-10-01 2015-10-01 false Title. 1832.1009 Section... CONTRACTING REQUIREMENTS CONTRACT FINANCING Performance-Based Payments 1832.1009 Title. In accordance with 42 U.S.C. 2465d, NASA shall not take title to launch vehicles under contracts for launch...

  18. A Manual for Enforcing Title I Comparability.

    ERIC Educational Resources Information Center

    Lawyers' Committee for Civil Rights Under Law, Washington, DC.

    This manual is a detailed guide to the "comparability requirement" and other provisions of Title I of the Elementary and Secondary Education Act of 1965 which are intended to ensure that Title I programs provide compensatory education. Section I gives an overview of Title I and its comparability provision. Section II shows how to read and analyze…

  19. Five steps toward title V permitting

    SciTech Connect

    Shrock, J.

    1994-06-01

    Title V of the Clean Air Act Amendments will have a profound effect on industry. Industry should be aware that preparing a Title V permit application is a significant undertaking. If a Title V operating permit is required, the recommended approach is described.

  20. 48 CFR 1371.111 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Title. 1371.111 Section... REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP REPAIR Provisions and Clauses 1371.111 Title. Insert clause 1352.271-80, Title, in all solicitations and contracts for ship repair....

  1. 24 CFR 242.76 - Title evidence.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title evidence. 242.76 Section 242... INSURANCE FOR HOSPITALS Miscellaneous Requirements § 242.76 Title evidence. Upon insurance of the mortgage... policy of title insurance covering the property, as provided in paragraph (a) of this section. If,...

  2. 24 CFR 241.1085 - Title evidence.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title evidence. 241.1085 Section...-Eligibility Requirements § 241.1085 Title evidence. (a) Upon insurance of the loan, the lender shall furnish to the Commissioner a policy of title insurance as provided in paragraph (a)(1) of this section....

  3. 12 CFR 543.1 - Corporate title.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Corporate title. 543.1 Section 543.1 Banks and...-INCORPORATION, ORGANIZATION, AND CONVERSION § 543.1 Corporate title. (a) General. A Federal savings association shall not adopt a title that misrepresents the nature of the institution or the services it offers....

  4. 24 CFR 242.75 - Title requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title requirements. 242.75 Section... INSURANCE FOR HOSPITALS Miscellaneous Requirements § 242.75 Title requirements. In order for the mortgaged property to be eligible for insurance, HUD shall determine that marketable title thereto is vested in...

  5. 25 CFR 151.13 - Title examination.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Title examination. 151.13 Section 151.13 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LAND ACQUISITIONS § 151.13 Title... unrestricted fee status to trust status, he shall acquire, or require the applicant to furnish, title...

  6. 48 CFR 1832.1009 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Title. 1832.1009 Section... CONTRACTING REQUIREMENTS CONTRACT FINANCING Performance-Based Payments 1832.1009 Title. In accordance with 42 U.S.C. 2465d, NASA shall not take title to launch vehicles under contracts for launch...

  7. 7 CFR 2812.6 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS, DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will...

  8. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-77 Title. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (OCT 1994) (a) Unless otherwise... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Title. 1252.217-77...

  9. 48 CFR 32.1009 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Title. 32.1009 Section 32... REQUIREMENTS CONTRACT FINANCING Performance-Based Payments 32.1009 Title. (a) Since the clause at 52.232-32, Performance-Based Payments, gives the Government title to the property described in paragraph (f) of...

  10. Practical experience with Title V

    SciTech Connect

    Hoffnagle, G.F.

    1996-12-31

    Having prepared numerous Title V permit applications and applications for synthetic minor status, the do`s and don`ts of this experience are evaluated. The philosophy for what goes into the application is reviewed, with special regard to the EPA {open_quotes}White Paper{close_quotes} on streamlining the process. The pros and cons of accepting and applying for synthetic minor status are evaluated.

  11. Avoiding Title V permitting pitfalls

    SciTech Connect

    Laswell, D.L.

    1993-04-01

    Title V of the 1990 Clean Air Act Amendments requires states to implement new air operating permit programs. States have a great deal of flexibility in developing their permit programs. Industry should work now to ensure that state programs contain the favorable aspects of the federal regulations and do not contain more stringent requirements that are not required under the Clean Air Act. This article outlines areas of the permit program that have the potential to handicap industry`s ability to expand.

  12. Title V Community Prevention Grants Program. 2000 Report to Congress.

    ERIC Educational Resources Information Center

    Caliber Associates, Fairfax, VA.

    This seventh annual report describes activities and accomplishments of grant activities funded under Title V, the Community Prevention Grants Program; procedures for disseminating grant products and research findings; activities conducted to develop policy and coordinate federal agency and interagency efforts related to delinquency prevention; and…

  13. Bilingual/Bicultural Education: Titles and Abstracts of Doctoral Dissertations.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    Dissertation abstracts describing research on a wide variety of topics in bilingual education are presented. This publication is designed to provide background material for bilingual educators as well as practical procedures for bilingual teachers, administrators, counselors, and evaluators. The titles were acquired by using the two broad…

  14. 48 CFR 35.014 - Government property and title.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Government property and... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.014 Government property and title. (a) The requirements in part 45 for establishing and maintaining control over Government...

  15. 42 CFR 476.86 - Correlation of Title XI functions with Title XVIII functions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Correlation of Title XI functions with Title XVIII functions. 476.86 Section 476.86 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF...) Qio Review Functions § 476.86 Correlation of Title XI functions with Title XVIII functions....

  16. Heat transfer measurements from a NACA 0012 airfoil in flight and in the NASA Lewis icing research tunnel. M.S. Thesis Final Report

    NASA Technical Reports Server (NTRS)

    Poinsatte, Philip E.

    1990-01-01

    Local heat transfer coefficients from a smooth and roughened NACA 0012 airfoil were measured using a steady state heat flux method. Heat transfer measurements on the specially constructed 0.533 meter chord airfoil were made both in flight on the NASA Lewis Twin Otter Research Aircraft and in the NASA Lewis Icing Research Tunnel (IRT). Roughness was obtained by the attachment of small, 2 mm diameter, hemispheres of uniform size to the airfoil surface in four distinct patterns. The flight data was taken for the smooth and roughened airfoil at various Reynolds numbers based on chord in the range of 1.24x10(exp 6) to 2.50x10(exp 6) and at various angles of attack up to 4 degrees. During these flight tests the free stream velocity turbulence intensity was found to be very low (less than 0.1 percent). The wind tunnel data was taken in the Reynolds number range of 1.20x10(exp 6) to 4.52x10(exp 6) and at angles of attack from -4 degrees to +8 degrees. The turbulence intensity in the IRT was 0.5 to 0.7 percent with the cloud making spray off. Results for both the flight and tunnel tests are presented as Frossling number based on chord versus position on the airfoil surface for various roughnesses and angle of attack. A table of power law curve fits of Nusselt number as a function of Reynolds number is also provided. The higher level of turbulence in the IRT versus flight had little effect on heat transfer for the lower Reynolds numbers but caused a moderate increase in heat transfer at the higher Reynolds numbers. Turning on the cloud making spray air in the IRT did not alter the heat transfer. Roughness generally increased the heat transfer by locally disturbing the boundary layer flow. Finally, the present data was not only compared with previous airfoil data where applicable, but also with leading edge cylinder and flat plate heat transfer values which are often used to estimate airfoil heat transfer in computer codes.

  17. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code....

  18. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code....

  19. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code....

  20. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code....

  1. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code....

  2. Summary of the Regulation for Title IX Education Amendments of 1972.

    ERIC Educational Resources Information Center

    Association of American Colleges, Washington, DC. Project on the Status and Education of Women.

    Title IX of the Education Amendemtns of 1972 bars sex discrimination in any academic, extracurricular, research, occupational training or other educational program operated by an organization or agency that receives or benefits from federal aid. The regulation (45 CFR Part 86) for Title IX summarized in this document falls into five categories:…

  3. Title IX Compliance at Two-Year Colleges: An Analysis of Perceived Barriers and Strategies

    ERIC Educational Resources Information Center

    Causby, Cory Scott

    2010-01-01

    Although Title IX legislation has been in effect since 1972 and has created unprecedented positive change on intercollegiate athletics, educational institutions have still had difficulty meeting the basic requirements set forth by Title IX and ensuring gender equity in their athletic programs. Additionally, specific research has been largely…

  4. Characteristics of and Strategies Used by Principals Who Promote Academic Success in Title I Classified Schools

    ERIC Educational Resources Information Center

    Cohen, Kimberly Kay

    2013-01-01

    This research is an attempt to explore the various strategies employed by the principals of Title I schools in order to foster an environment of student progress and achievement. Since the inception of the NCLB Act, pressures have been increasing on the schools, especially on Title I Schools, and on their principals to increase academic…

  5. Strengthening Title I to Help High-Poverty Schools: How Title I Funds Fit into District Allocation Patterns

    ERIC Educational Resources Information Center

    Roza, Marguerite

    2005-01-01

    Despite the fact that funding for Title I continues to grow, and the program is now the major funding arm of "No Child Left Behind", the research reported here indicates that funds are not always spent in a way likely to accomplish the purposes of the legislation. In most urban districts a systematic bias is built into the district allocation…

  6. LC-MS/MS quantitation of plasma progesterone in cattle.

    PubMed

    Fernandes, R M T; Gomes, G C; Porcari, A M; Pimentel, J R V; Porciúncula, P M; Martins-Júnior, H A; Miguez, P H P; da Costa, J L; Amaral, P H; Perecin, F; Meurer, E C; Furtado, P V; Simas, R C; Eberlin, M N; Ferreira, C R; Madureira, E H

    2011-10-15

    Quantitation of progesterone (P(4)) in biological fluids is often performed by radioimmunoassay (RIA), whereas liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) has been used much less often. Due to its autoconfirmatory nature, LC-MS/MS greatly minimizes false positives and interference. Herein we report and compare with RIA an optimized LC-MS/MS method for rapid, efficient, and cost-effective quantitation of P(4) in plasma of cattle with no sample derivatization. The quantitation of plasma P(4) released from three nonbiodegradable, commercial, intravaginal P(4)-releasing devices (IPRD) over 192 h in six ovariectomized cows was compared in a pairwise study as a test case. Both techniques showed similar P(4) kinetics (P > 0.05) whereas results of P(4) quantitation by RIA were consistently higher compared with LC-MS/MS (P < 0.05) due to interference and matrix effects. The LC-MS/MS method was validated according to the recommended analytical standards and displayed P(4) limits of detection (LOD) and quantitation (LOQ) of 0.08 and a 0.25 ng/mL, respectively. The high selective LC-MS/MS method proposed herein for P(4) quantitation eliminates the risks associated with radioactive handling; it also requires no sample derivatization, which is a common requirement for LC-MS/MS quantitation of steroid hormones. Its application to multisteroid assays is also viable, and it is envisaged that it may provide a gold standard technique for hormone quantitation in animal reproductive science studies. PMID:21798587

  7. Implementing Title III -- Air toxics

    SciTech Connect

    Shaw, B.W.

    1995-12-31

    The South Coast Air Quality Management District (AQMD) is taking three basic approaches to implementing the new National Emissions Standards for Hazardous Air Pollutants (NESHAPs) from the Title III program: accept and implement, as written, the NESHAPs where few sources are located in the South Coast Air Basin; incorporate with simplification of the NESHAP requirements into AQMD rules when many sources are involved; then seek equivalency by the US EPA; and incorporate with a market-based rule (VOC RECLAIM), part of many NESHAPs which control volatile organic compound as HAPs. Whatever the approach, emphasis will be placed on: streamlining and simplification; helping sources understand requirements and comply; and common sense.

  8. Cannabinoids determination in oral fluid by SPME-GC/MS and UHPLC-MS/MS and its application on suspected drivers.

    PubMed

    Anzillotti, Luca; Castrignanò, Erika; Strano Rossi, Sabina; Chiarotti, Marcello

    2014-12-01

    The confirmation of Δ9-tetrahydrocannabinol (THC) in oral fluid (OF) is an important issue for assessing Driving Under the Influence of Drugs (DUID). The aim of this research was to develop a highly sensitive method with minimal sample pre-treatment suitable for the analysis of small OF volumes (100 μL) for the confirmation of cannabinoids in DUID cases. Two methods were compared for the confirmation of THC in residual OF samples, obtained from a preliminary on-site screening with commercial devices. An ultra high performance LC-MS (UHPLC-MS/MS) method and an SPME-GC/MS method were hence developed. 100 μL of the residual mixture OF/preservative buffer or neat OF was simply added to 10 μL of THC-D3 (1 μg/mL) and submitted to the two different analyses: A - direct injection of 10 μL in UHPLC-MS/MS in positive electrospray ionisation (ESI) mode and B - sampling for 30 min with SPME (100 μm polydimethylsiloxane or PDMS fibre) and direct injection by desorption of the fibre in the GC injection port. The lowest limit of detection (LLOD) of THC was 2 ng/mL in UHPLC-MS/MS and 0.5 ng/mL in SPME-GC/MS. In addition, cannabidiol (CBD) and cannabinol (CBN) could be detected in GC/MS equipment at 2 ng/mL, whilst in UHPLC-MS/MS the LLOD was 20 ng/mL. Both methods were applied to 70 samples coming from roadside tests. By SPME-GC/MS analysis, THC was confirmed in 42 samples, whilst CBD was detected in 21 of them, along with CBN in 14 samples. THC concentrations ranged from traces below the lowest limit of quantification or LLOQ (2 ng/mL) up to 690 ng/mL. PMID:25498928

  9. 32 CFR 644.71 - Final Title Assembly.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Final Title Assembly. 644.71 Section 644.71... ESTATE HANDBOOK Acquisition Procurement of Title Evidence, Title Clearance, and Closings § 644.71 Final Title Assembly. (a) Disposition of final title assemblies. The final title opinion and related...

  10. Polyamine analysis by LC-MS.

    PubMed

    Häkkinen, Merja R

    2011-01-01

    This chapter describes a protocol to analyze polyamines without any derivatization steps utilizing LC-MS/MS. Polyamines are separated by reversed phase LC prior MS analysis using heptafluorobutyric acid as MS compatible volatile ion-pairing agent, and selective and sensitive MS detection is performed using MS/MS in selected reaction monitoring mode.

  11. MS-DIAL: Data Independent MS/MS Deconvolution for Comprehensive Metabolome Analysis

    PubMed Central

    Tsugawa, Hiroshi; Cajka, Tomas; Kind, Tobias; Ma, Yan; Higgins, Brendan; Ikeda, Kazutaka; Kanazawa, Mitsuhiro; VanderGheynst, Jean; Fiehn, Oliver; Arita, Masanori

    2015-01-01

    Data-independent acquisition (DIA) in liquid chromatography tandem mass spectrometry (LC-MS/MS) provides more comprehensive untargeted acquisition of molecular data. Here we provide an open-source software pipeline, MS-DIAL, to demonstrate how DIA improves simultaneous identification and quantification of small molecules by mass spectral deconvolution. For reversed phase LC-MS/MS, our program with an enriched LipidBlast library identified total 1,023 lipid compounds from nine algal strains to highlight their chemotaxonomic relationships. PMID:25938372

  12. Energy Data Base: Serial titles with ISSN listing: Part 1, Alphabetic arrangement by title

    SciTech Connect

    Daniel, J.H.

    1986-12-01

    ''Serial Titles with ISSN Listing'' lists periodical titles which have been included in the OSTI (Office of Scientific and Technical Information) Journal Authority. The OSTI Journal Authority was established to standardize the citing of the approximately 23,000 titles contained in this authority. It is also a valuable tool for identifying journals by ISSN and CODEN, especially for journals with the same title which are published in different locations. This Part 1 is an alphabetical listing by full title of the journal publication and also includes abbreviated title, CODEN, ISSN, coverage code, and country code.

  13. Integrated LC-MS/MS system for plant metabolomics

    PubMed Central

    Sawada, Yuji; Hirai, Masami Yokota

    2013-01-01

    Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is highly sensitive, selective, and enables extensive detection of metabolites within a sample. The result allows us to characterize comprehensive metabolite accumulation patterns without dependence on authentic standard compounds and isolation of the individual metabolites. A reference database search is essential for the structural assignment process of un-targeted MS and MS/MS data. Moreover, the characterization of unknown metabolites is challenging, since these cannot be assigned a candidate structure by using a reference database. In this case study, integrated LC-MS/MS based plant metabolomics allows us to detect several hundred metabolites in a sample; and integrated omics analyses, e.g., large-scale reverse genetics, linkage mapping, and association mapping, provides a powerful tool for candidate structure selection or rejection. We also examine emerging technology and applications for LC-MS/MS-based un-targeted plant metabolomics. These activities promote the characterization of massive extended detectable metabolites. PMID:24688692

  14. 13 CFR § 314.7 - Title.

    Code of Federal Regulations, 2010 CFR

    2015-01-01

    ... 13 Business Credit and Assistance 1 2015-01-01 2015-01-01 false Title. § 314.7 Section § 314.7... Property § 314.7 Title. Link to an amendment published at 79 FR 76137, Dec. 19, 2014. (a) General. The Recipient must hold title to the Real Property required for a Project at the time the Investment...

  15. Innovative methodology to transfer conventional GC-MS heroin profiling to UHPLC-MS/MS.

    PubMed

    Debrus, B; Broséus, J; Guillarme, D; Lebrun, P; Hubert, P; Veuthey, J-L; Esseiva, P; Rudaz, S

    2011-03-01

    Nowadays, in forensic laboratories, heroin profiling is frequently carried out by gas chromatography coupled with mass spectrometry (GC-MS). This analytical technique is well established, provides good sensitivity and reproducibility, and allows the use of large databases. Despite those benefits, recently introduced analytical techniques, such as ultra-high-pressure liquid chromatography (UHPLC), could offer better chromatographic performance, which needs to be considered to increase the analysis throughput for heroin profiling. With the latter, chromatographic conditions were optimized through commercial modeling software and two atmospheric pressure ionization sources were evaluated. Data obtained from UHPLC-MS/MS were thus transferred, thanks to mathematical models to mimic GC-MS data. A calibration and a validation set of representative heroin samples were selected among the database to establish a transfer methodology and assess the models' abilities to transfer using principal component analysis and hierarchical classification analysis. These abilities were evaluated by computing the frequency of successful classification of UHPLC-MS/MS data among GC-MS database. Seven mathematical models were tested to adjust UHPLC-MS/MS data to GC-MS data. A simplified mathematical model was finally selected and offered a frequency of successful transfer equal to 95%.

  16. Relapsing-Remitting MS (RRMS)

    MedlinePlus

    ... pdf) Download Brochure Taming Stress (.pdf) Download Brochure Multiple Sclerosis and Your Emotions (.pdf) Download Brochure Disease Modifying Therapies Overview (.pdf) Download Document Pediatric MS Learn More ...

  17. Hydrogen Rearrangement Rules: Computational MS/MS Fragmentation and Structure Elucidation Using MS-FINDER Software.

    PubMed

    Tsugawa, Hiroshi; Kind, Tobias; Nakabayashi, Ryo; Yukihira, Daichi; Tanaka, Wataru; Cajka, Tomas; Saito, Kazuki; Fiehn, Oliver; Arita, Masanori

    2016-08-16

    Compound identification from accurate mass MS/MS spectra is a bottleneck for untargeted metabolomics. In this study, we propose nine rules of hydrogen rearrangement (HR) during bond cleavages in low-energy collision-induced dissociation (CID). These rules are based on the classic even-electron rule and cover heteroatoms and multistage fragmentation. We evaluated our HR rules by the statistics of MassBank MS/MS spectra in addition to enthalpy calculations, yielding three levels of computational MS/MS annotation: "resolved" (regular HR behavior following HR rules), "semiresolved" (irregular HR behavior), and "formula-assigned" (lacking structure assignment). With this nomenclature, 78.4% of a total of 18506 MS/MS fragment ions in the MassBank database and 84.8% of a total of 36370 MS/MS fragment ions in the GNPS database were (semi-) resolved by predicted bond cleavages. We also introduce the MS-FINDER software for structure elucidation. Molecular formulas of precursor ions are determined from accurate mass, isotope ratio, and product ion information. All isomer structures of the predicted formula are retrieved from metabolome databases, and MS/MS fragmentations are predicted in silico. The structures are ranked by a combined weighting score considering bond dissociation energies, mass accuracies, fragment linkages, and, most importantly, nine HR rules. The program was validated by its ability to correctly calculate molecular formulas with 98.0% accuracy for 5063 MassBank MS/MS records and to yield the correct structural isomer with 82.1% accuracy within the top-3 candidates. In a test with 936 manually identified spectra from an untargeted HILIC-QTOF MS data set of human plasma, formulas were correctly predicted in 90.4% of the cases, and the correct isomer structure was retrieved at 80.4% probability within the top-3 candidates, including for compounds that were absent in mass spectral libraries. The MS-FINDER software is freely available at http

  18. Hydrogen Rearrangement Rules: Computational MS/MS Fragmentation and Structure Elucidation Using MS-FINDER Software.

    PubMed

    Tsugawa, Hiroshi; Kind, Tobias; Nakabayashi, Ryo; Yukihira, Daichi; Tanaka, Wataru; Cajka, Tomas; Saito, Kazuki; Fiehn, Oliver; Arita, Masanori

    2016-08-16

    Compound identification from accurate mass MS/MS spectra is a bottleneck for untargeted metabolomics. In this study, we propose nine rules of hydrogen rearrangement (HR) during bond cleavages in low-energy collision-induced dissociation (CID). These rules are based on the classic even-electron rule and cover heteroatoms and multistage fragmentation. We evaluated our HR rules by the statistics of MassBank MS/MS spectra in addition to enthalpy calculations, yielding three levels of computational MS/MS annotation: "resolved" (regular HR behavior following HR rules), "semiresolved" (irregular HR behavior), and "formula-assigned" (lacking structure assignment). With this nomenclature, 78.4% of a total of 18506 MS/MS fragment ions in the MassBank database and 84.8% of a total of 36370 MS/MS fragment ions in the GNPS database were (semi-) resolved by predicted bond cleavages. We also introduce the MS-FINDER software for structure elucidation. Molecular formulas of precursor ions are determined from accurate mass, isotope ratio, and product ion information. All isomer structures of the predicted formula are retrieved from metabolome databases, and MS/MS fragmentations are predicted in silico. The structures are ranked by a combined weighting score considering bond dissociation energies, mass accuracies, fragment linkages, and, most importantly, nine HR rules. The program was validated by its ability to correctly calculate molecular formulas with 98.0% accuracy for 5063 MassBank MS/MS records and to yield the correct structural isomer with 82.1% accuracy within the top-3 candidates. In a test with 936 manually identified spectra from an untargeted HILIC-QTOF MS data set of human plasma, formulas were correctly predicted in 90.4% of the cases, and the correct isomer structure was retrieved at 80.4% probability within the top-3 candidates, including for compounds that were absent in mass spectral libraries. The MS-FINDER software is freely available at http://prime.psc.riken.jp/ .

  19. Stable Isotope Labeled Tracers for Metabolic Pathway Elucidation by GC-MS and FT-MS

    PubMed Central

    Higashi, Richard M.; Fan, Teresa W-M.; Lorkiewicz, Pawel K.; Moseley, Hunter N.B.; Lane, Andrew N.

    2015-01-01

    Advances in analytical methodologies, principally nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS), over the last decade have made large-scale analysis of the human metabolome a reality. This is leading to the reawakening of the importance of metabolism in human diseases, particularly widespread metabolic diseases such as cancer, diabetes, and obesity. Emerging NMR and MS atom-tracking technologies and informatics is poised to revolutionize metabolomics-based research because they deliver the high information throughput (HIT) that is needed for deciphering systems biochemistry. In particular, Stable Isotope Resolved Metabolomics (SIRM) enables unambiguous tracking of individual atoms through compartmentalized metabolic networks, in a wide range of experimental systems, including human subjects. MS offers a wide range of initial capital outlay and operating costs, ranging from gas-chromatography (GC) MS affordable by many individual laboratories, to the HIT-supporting Fourier-transform (FT) class of MS that rivals NMR in cost and infrastructure support. This chapter will focus on sample preparation, instrument, and data processing procedures for these two extremes of MS instrumentation used in SIRM. PMID:25270929

  20. High Throughput Analytical Techniques for the Determination and Confirmation of Residues of 653 Multiclass Pesticides and Chemical Pollutants in Tea by GC/MS, GC/MS/MS, and LC/MS/MS: Collaborative Study, First Action 2014.09.

    PubMed

    Pang, Guo-Fang; Fan, Chun-Lin; Cao, Yan-Zhong; Yan, Fang; Li, Yan; Kang, Jian; Chen, Hui; Chang, Qiao-Ying

    2015-01-01

    Thirty laboratories from fom North and South America, Europe, and Asia participated in this AOAC collaborative study (15 from China; five from Germany; two each from Italy and the United States; and one each from the Republic of Korea, Canada, Spain, Japan, Belgium, and India). Participants represented government regulatory, commercial testing, university, research institute, and private laboratories. The single-laboratory validated (SLV) tea method was evaluated in the collaborative study to determine the recovery and reproducibility of the method under multilaboratory conditions. Since there were no restrictions regarding the type of analytical instrumentation to use for the analyses, laboratories used a combination of equipment that included GC/MS, GC/MS/MS, and LC/MS/MS instruments from 22 different manufacturers, 21 brands of GC and LC columns, 13 different GC temperature programming profiles, 11 LC gradient elution programs, and six different vendor manufactured SPE cartridges. Even though all the analytical performance parameters for all the 653 compounds had been determined in the SLV study, guidance was obtained from an expert review panel of the AOAC Method-Centric Committee on Pesticide Residues to conduct the multilaboratory collaborative study based on 20 selected compounds that can be analyzed by GC/MS and 20 compounds that can be analyzed by LC/MS/MS. Altogether, 560 samples covering the 40 selected pesticides were analyzed in the study. These samples included green tea and oolong tea samples fortified typically at the European Union maximum residue limit for regulatory guidance and compliance, aged tea samples incurred with 20 pesticides, and green tea and oolong tea samples incurred with five pesticides. The analysis of the 560 samples generated a total of 82 459 test results by the 30 participating laboratories. One laboratory failed to meet the proficiency requirements in the precollaborative study. Therefore, its data submitted for the

  1. Title IX: A Brief History. 25 Years of Title IX. WEEA Digest.

    ERIC Educational Resources Information Center

    Valentin, Iram

    This brief history of Title IX points out that the role of women and girls in education and the work force began to change significantly with the passage of Title IX as part of the Education Amendments to the Civil Rights Act of 1964. Title IX ensures legal protection against discrimination for students and employees. This article discusses the…

  2. 45 CFR Subject Index to Title IX... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2015-10-01

    ... 45 Public Welfare 1 2015-10-01 2015-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare Department of Health and... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]....

  3. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2002-10-01

    ... 45 Public Welfare 1 2002-10-01 2002-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare GENERAL ADMINISTRATION... FINANCIAL ASSISTANCE Procedures Interim procedures. Pt. 86, Index Subject Index to Title IX Preamble...

  4. 45 CFR Subject Index to Title IX... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2006-10-01

    ... 45 Public Welfare 1 2006-10-01 2006-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]....

  5. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2005-10-01

    ... 45 Public Welfare 1 2005-10-01 2005-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTH AND... to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets . A Access...

  6. 34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2005-07-01

    ... 34 Education 1 2005-07-01 2005-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the.... Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are...

  7. 34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2002-07-01

    ... 34 Education 1 2002-07-01 2002-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Regulations of the Offices of the Department.... Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are...

  8. 34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2008-07-01

    ... 34 Education 1 2008-07-01 2008-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the.... Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are...

  9. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation \\1\\

    Code of Federal Regulations, 2010 CFR

    1998-10-01

    ... 45 Public Welfare 1 1998-10-01 1998-10-01 false Subject Index to Title IX Preamble and Regulation \\1\\ Index Subject Index to Title IX Preamble and Regulation \\1\\ GENERAL ADMINISTRATION... FINANCIAL ASSISTANCE Procedures Interim procedures. Pt. 86, Index Subject Index to Title IX Preamble...

  10. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation \\1\\

    Code of Federal Regulations, 2010 CFR

    2000-10-01

    ... 45 Public Welfare 1 2000-10-01 2000-10-01 false Subject Index to Title IX Preamble and Regulation \\1\\ Index Subject Index to Title IX Preamble and Regulation \\1\\ Public Welfare DEPARTMENT OF.... Pt. 86, Index Subject Index to Title IX Preamble and Regulation \\1\\ 1 Preamble paragraph numbers...

  11. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2003-10-01

    ... 45 Public Welfare 1 2003-10-01 2003-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND..., Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in...

  12. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2009-10-01

    ... 45 Public Welfare 1 2009-10-01 2009-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTH AND... to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets . A Access...

  13. 34 CFR Subject Index to Title IX... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2015-07-01

    ... 34 Education 1 2015-07-01 2015-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph...

  14. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2001-10-01

    ... 45 Public Welfare 1 2001-10-01 2001-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND..., Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in...

  15. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2004-10-01

    ... 45 Public Welfare 1 2004-10-01 2004-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND..., Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in...

  16. 34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2007-07-01

    ... 34 Education 1 2007-07-01 2007-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the.... Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are...

  17. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2008-10-01

    ... 45 Public Welfare 1 2008-10-01 2008-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND... to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets . A Access...

  18. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation \\1\\

    Code of Federal Regulations, 2010 CFR

    1999-10-01

    ... 45 Public Welfare 1 1999-10-01 1999-10-01 false Subject Index to Title IX Preamble and Regulation \\1\\ Index Subject Index to Title IX Preamble and Regulation \\1\\ Public Welfare DEPARTMENT OF.... Pt. 86, Index Subject Index to Title IX Preamble and Regulation \\1\\ 1 Preamble paragraph numbers...

  19. 34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2003-07-01

    ... 34 Education 1 2003-07-01 2003-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the.... Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are...

  20. 34 CFR Subject Index to Title IX... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2016-07-01

    ... 34 Education 1 2016-07-01 2016-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph...

  1. 34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2004-07-01

    ... 34 Education 1 2004-07-01 2004-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the.... Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are...

  2. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2007-10-01

    ... 45 Public Welfare 1 2007-10-01 2007-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND... to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets . A Access...

  3. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation \\1\\

    Code of Federal Regulations, 2010 CFR

    1997-10-01

    ... 45 Public Welfare 1 1997-10-01 1997-10-01 false Subject Index to Title IX Preamble and Regulation \\1\\ Index Subject Index to Title IX Preamble and Regulation \\1\\ GENERAL ADMINISTRATION... FINANCIAL ASSISTANCE Procedures Interim procedures. Pt. 86, Index Subject Index to Title IX Preamble...

  4. 34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2006-07-01

    ... 34 Education 1 2006-07-01 2006-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the.... Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are...

  5. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation \\1\\

    Code of Federal Regulations, 2010 CFR

    1996-10-01

    ... 45 Public Welfare 1 1996-10-01 1996-10-01 false Subject Index to Title IX Preamble and Regulation \\1\\ Index Subject Index to Title IX Preamble and Regulation \\1\\ NONDISCRIMINATION ON THE BASIS OF SEX... Procedures Interim procedures. Pt. 86, Index Subject Index to Title IX Preamble and Regulation \\1\\ 1...

  6. 34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2009-07-01

    ... 34 Education 1 2009-07-01 2009-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the.... Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are...

  7. Title IX and Pregnancy Discrimination in Higher Education: The New Frontier.

    PubMed

    Mason, Mary Ann; Younger, Jaclyn

    2014-01-01

    Pregnancy discrimination is a little known area covered by Title IX. According to the Title IX regulations, areas of prohibited discrimination include: admissions; hiring; coursework accommodations and completion; pregnancy leave policies and status protection upon return from leave; and health insurance coverage. These regulations will soon get more attention as the Obama Administration insists on Title IX dissemination and compliance in an effort to stop the leaky pipeline for women in the STEM fields. Research shows that pregnancy and childbirth are the major reasons why women drop out of research science in much greater numbers than men; this dropout is most likely to occur among graduate students and postdoctoral fellows who are in their peak childbearing years. A similar pattern of dropout can be seen in all fields, including related professional schools. Research also reveals that there are currently few established policies in higher education which adequately address pregnancy and childbirth in formal policies for students. This article will address new efforts by the United States Department of Education and the federal agencies to begin to seek compliance relating to Title IX and pregnancy discrimination in educational institutions. It will discuss the recent successful efforts of the U.S. Department of Education's Office for Civil Rights in investigating and settling pregnancy discrimination claims as well as the lessons learned in private action lawsuits under Title IX. Title IX private action suits have transformed athletics for women, and more recently Title IX has been applied in sexual harassment cases. Pregnancy discrimination is now the new frontier.

  8. 75 FR 26711 - Notice of New Recreation Fee Site; Federal Lands Recreation Enhancement Act, (Title VIII, Pub. L...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... Forest Service Notice of New Recreation Fee Site; Federal Lands Recreation Enhancement Act, (Title VIII... Recreation Fee Site. SUMMARY: Bethel Motorcycle and Bethel ATV Trails are located near Saucier, MS. Currently..., Recreation Program Manager, 601-965-1617, National Forests in Mississippi, 100 West Capitol Street,...

  9. 40 CFR 105.3 - Title.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Title. 105.3 Section 105.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT General § 105.3 Title. The awards are known as the National Clean Water...

  10. 40 CFR 105.3 - Title.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Title. 105.3 Section 105.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT General § 105.3 Title. The awards are known as the National Clean Water...

  11. 40 CFR 105.3 - Title.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Title. 105.3 Section 105.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT General § 105.3 Title. The awards are known as the National Clean Water...

  12. Arkansas HEA Title II. State Report, 2004

    ERIC Educational Resources Information Center

    Arkansas Department of Education, 2005

    2005-01-01

    In October 1998, Congress enacted Title II, Sections 207 and 208 (as amendments to the Higher Education Act) which support the efforts of States, Institutions of Higher Education, and their School District partners to improve the recruitment, preparation, and support of new teachers. The Title II report includes specifications, conditions and…

  13. Automated Title Page Cataloging: A Feasibility Study.

    ERIC Educational Resources Information Center

    Weibel, Stuart; And Others

    1989-01-01

    Describes the design of a prototype rule-based system for the automation of descriptive cataloging from title pages. The discussion covers the results of tests of the prototype, major impediments to automatic cataloging from title pages, and prospects for further progress. The rules implemented in the prototype are appended. (16 references)…

  14. Statistical Evidence and Compliance with Title IX

    ERIC Educational Resources Information Center

    Cheslock, John J.; Eckes, Suzanne E.

    2008-01-01

    The scope of Title IX clearly includes all aspects of education, but the legislation's application to college athletics receives the most attention. Athletics programs, unlike most academic activities, are sex segregated, so the proper interpretation of the intercollegiate athletics provisions of Title IX is less clear-cut. This article examines…

  15. Title IX and Sex Discrimination. Revised.

    ERIC Educational Resources Information Center

    Office for Civil Rights (ED), Washington, DC.

    Title IX of the Education Amendments of 1972 protects people from discrimination based on sex in education programs or activities that receive Federal financial assistance. This brochure outlines the responsibilities of education programs and activities covered by Title IX, the responsibilities of the Office for Civil Rights (OCR) in enforcing…

  16. 29 CFR 18.1103 - Title.

    Code of Federal Regulations, 2010 CFR

    2002-07-01

    ... ADMINISTRATIVE LAW JUDGES Rules of Evidence Applicability § 18.1103 Title. These rules may be known as the United States Department of Labor Rules of Evidence and cited as 29 CFR 18.__ (1989). ... 29 Labor 1 2002-07-01 2001-07-01 true Title. 18.1103 Section 18.1103 Labor Office of the...

  17. 40 CFR § 105.3 - Title.

    Code of Federal Regulations, 2010 CFR

    2016-07-01

    ... 40 Protection of Environment 24 2016-07-01 2016-07-01 false Title. § 105.3 Section § 105.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT General § 105.3 Title. The awards are known as the National Clean Water...

  18. 33 CFR 402.2 - Title.

    Code of Federal Regulations, 2010 CFR

    2009-07-01

    ... 33 Navigation and Navigable Waters 3 2009-07-01 2009-07-01 false Title. 402.2 Section 402.2 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT CORPORATION, DEPARTMENT OF TRANSPORTATION TARIFF OF TOLLS § 402.2 Title. This tariff may be cited as the St. Lawrence Seaway Tariff of...

  19. 29 CFR 18.1103 - Title.

    Code of Federal Regulations, 2010 CFR

    2001-07-01

    ... ADMINISTRATIVE LAW JUDGES Rules of Evidence Applicability § 18.1103 Title. These rules may be known as the United States Department of Labor Rules of Evidence and cited as 29 CFR 18.__ (1989). ... 29 Labor 1 2001-07-01 2001-07-01 false Title. 18.1103 Section 18.1103 Labor Office of...

  20. 45 CFR 1309.20 - Title.

    Code of Federal Regulations, 2010 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Title. 1309.20 Section 1309.20 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH... FACILITIES PURCHASE, MAJOR RENOVATION AND CONSTRUCTION Protection of Federal Interest § 1309.20 Title....

  1. 40 CFR 105.3 - Title.

    Code of Federal Regulations, 2010 CFR

    2011-07-01

    ... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Title. 105.3 Section 105.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT General § 105.3 Title. The awards are known as the National Clean Water...

  2. 33 CFR 402.2 - Title.

    Code of Federal Regulations, 2010 CFR

    1999-07-01

    ... 33 Navigation and Navigable Waters 3 1999-07-01 1999-07-01 false Title. 402.2 Section 402.2 Navigation and Navigable Waters SAINT LAWRENCE SEAWAYDEVELOPMENT CORPORATION, DEPARTMENT OF TRANSPORTATION TARIFF OF TOLLS § 402.2 Title. This tariff may be cited as the St. Lawrence Seaway Tariff of Tolls....

  3. 45 CFR 1309.20 - Title.

    Code of Federal Regulations, 2010 CFR

    2005-10-01

    ... 45 Public Welfare 4 2005-10-01 2005-10-01 false Title. 1309.20 Section 1309.20 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH... FACILITIES PURCHASE, MAJOR RENOVATION AND CONSTRUCTION Protection of Federal Interest § 1309.20 Title....

  4. 29 CFR 18.1103 - Title.

    Code of Federal Regulations, 2010 CFR

    2005-07-01

    ... ADMINISTRATIVE LAW JUDGES Rules of Evidence Applicability § 18.1103 Title. These rules may be known as the United States Department of Labor Rules of Evidence and cited as 29 CFR 18.__ (1989). ... 29 Labor 1 2005-07-01 2005-07-01 false Title. 18.1103 Section 18.1103 Labor Office of...

  5. 29 CFR 18.1103 - Title.

    Code of Federal Regulations, 2010 CFR

    2006-07-01

    ... ADMINISTRATIVE LAW JUDGES Rules of Evidence Applicability § 18.1103 Title. These rules may be known as the United States Department of Labor Rules of Evidence and cited as 29 CFR 18.__ (1989). ... 29 Labor 1 2006-07-01 2006-07-01 false Title. 18.1103 Section 18.1103 Labor Office of...

  6. 33 CFR § 402.2 - Title.

    Code of Federal Regulations, 2010 CFR

    2015-07-01

    ... 33 Navigation and Navigable Waters 3 2015-07-01 2015-07-01 false Title. § 402.2 Section § 402.2 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT CORPORATION, DEPARTMENT OF TRANSPORTATION TARIFF OF TOLLS § 402.2 Title. This tariff may be cited as the St. Lawrence Seaway Tariff of...

  7. 31 CFR 505.01 - Short title.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Short title. 505.01 Section 505.01 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... CERTAIN MERCHANDISE BETWEEN FOREIGN COUNTRIES § 505.01 Short title. The regulations in this part may...

  8. 40 CFR 105.3 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Title. 105.3 Section 105.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT General § 105.3 Title. The awards are known as the National Clean Water...

  9. 24 CFR 3500.16 - Title companies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Title companies. 3500.16 Section 3500.16 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT § 3500.16 Title companies. No seller of property that...

  10. 18 CFR 415.1 - Short title.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Short title. 415.1 Section 415.1 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-FLOOD PLAIN REGULATIONS Generally § 415.1 Short title. This part shall be...

  11. 33 CFR 402.2 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Title. 402.2 Section 402.2 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT CORPORATION, DEPARTMENT OF TRANSPORTATION TARIFF OF TOLLS § 402.2 Title. This tariff may be cited as the St. Lawrence Seaway Tariff of...

  12. 33 CFR 401.1 - Short title.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Short title. 401.1 Section 401.1 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT CORPORATION, DEPARTMENT OF TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations § 401.1 Short title. These regulations may be cited as...

  13. 45 CFR 1309.20 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Title. 1309.20 Section 1309.20 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH... FACILITIES PURCHASE, MAJOR RENOVATION AND CONSTRUCTION Protection of Federal Interest § 1309.20 Title....

  14. 29 CFR 18.1103 - Title.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ADMINISTRATIVE LAW JUDGES Rules of Evidence Applicability § 18.1103 Title. These rules may be known as the United States Department of Labor Rules of Evidence and cited as 29 CFR 18.__ (1989). ... 29 Labor 1 2010-07-01 2010-07-01 true Title. 18.1103 Section 18.1103 Labor Office of the...

  15. 18 CFR 415.1 - Short title.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Short title. 415.1 Section 415.1 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-FLOOD PLAIN REGULATIONS Generally § 415.1 Short title. This part shall be...

  16. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Title. 1252.217-77 Section 1252.217-77 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-77 Title. As prescribed at (TAR) 48 CFR 1217.7001(b) and...

  17. Great Expectations: Understanding the New Title I.

    ERIC Educational Resources Information Center

    Manasevit, Leigh M.; Cowan, Kristen Tosh

    On October 20, 1994, President Clinton signed into law the Improving America's Schools Act of 1994. This statute contains amendments to the Elementary and Secondary Education Act of 1965, including the reauthorization of Chapter 1, as the newly entitled Title I. The reauthorized Title I drastically restructures the direction of former remedial…

  18. Analysis of acrylamide by LC-MS/MS and GC-MS in processed Japanese foods.

    PubMed

    Ono, H; Chuda, Y; Ohnishi-Kameyama, M; Yada, H; Ishizaka, M; Kobayashi, H; Yoshida, M

    2003-03-01

    Acrylamide concentrations in processed foods (63 samples covering 31 product types) from Japan were analysed by LC-MS/MS and GC-MS methods. The limit of detection and limit of quantification of acrylamide were 0.2 ng x ml(-1) (6 fmol) and 0.8 ng x ml(-1) (22 fmol), respectively, by LC-MS/MS, and those of 2,3-dibromopropionamide derived from acrylamide were 12 ng x ml(-1) (52 fmol) and 40 ng x ml(-1) (170 fmol), respectively, by GC-MS. Repeatability given as RSD was <5 and <15% for the LC-MS/MS and GC-MS methods, respectively. High correlation (r(2) - 0.946) was observed between values obtained by the two methods. Most potato crisps and whole potato-based fried snacks showed acrylamide concentrations >1000 microg x kg(-1). The concentrations in non-whole potato-based snacks, rice crackers processed by grilling or frying, and candied sweet potatoes were lower compared with those in the potato crisps and the whole potato-based fried snacks. One of the whole potato-based fried snacks, however, showed low acrylamide concentration (<50 microg x kg(-1)) suggesting the formation of acrylamide is strongly influenced by processing conditions. Acrylamide concentrations in instant precooked noodles and won-tons were <100 microg x kg(-1) with only one exception. Roasted barley grains for 'Mugi-cha' tea contained 200-600 microg x kg(-1) acrylamide.

  19. Determination of Glyphosate Levels in Breast Milk Samples from Germany by LC-MS/MS and GC-MS/MS.

    PubMed

    Steinborn, Angelika; Alder, Lutz; Michalski, Britta; Zomer, Paul; Bendig, Paul; Martinez, Sandra Aleson; Mol, Hans G J; Class, Thomas J; Pinheiro, Nathalie Costa

    2016-02-17

    This study describes the validation and application of two independent analytical methods for the determination of glyphosate in breast milk. They are based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS), respectively. For LC-MS/MS, sample preparation involved an ultrafiltration followed by chromatography on an anion exchange column. The analysis by GC-MS/MS involved an extraction step, cleanup on a cation exchange column, and derivatization with heptafluorobutanol and trifluoroacetic acid anhydride. Both methods were newly developed for breast milk and are able to quantify glyphosate residues at concentrations as low as 1 ng/mL. The methods were applied to quantify glyphosate levels in 114 breast milk samples, which had been collected from August to September of 2015 in Germany. The mothers participated at their own request and thus do not form a representative sample. In none of the investigated samples were glyphosate residues above the limit of detection found.

  20. 12 CFR 611.1137 - Title VIII service corporations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Title VIII service corporations. 611.1137... Organizations § 611.1137 Title VIII service corporations. (a) What is a title VIII service corporation? A title... authorities granted under title VIII of the Act to act as an agricultural mortgage marketing facility. (b)...

  1. 24 CFR 203.389 - Waived title objections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Waived title objections. 203.389... SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Property Title Transfers and Title Waivers § 203.389 Waived title objections. The Commissioner shall not object to title by reason of...

  2. 7 CFR 1927.55 - Title clearance services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Title clearance services. 1927.55 Section 1927.55... REGULATIONS TITLE CLEARANCE AND LOAN CLOSING Real Estate Title Clearance and Loan Closing § 1927.55 Title... borrower by a closing agent in connection with the transaction vary depending on whether a title...

  3. 37 CFR 1.72 - Title and abstract.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Title and abstract. 1.72... Title and abstract. (a) The title of the invention may not exceed 500 characters in length and must be... created by the Office. Unless the title is supplied in an application data sheet (§ 1.76), the title...

  4. 25 CFR 150.8 - Title status reports.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Title status reports. 150.8 Section 150.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LAND RECORDS AND TITLE DOCUMENTS § 150.8 Title status reports. Land Titles and Records Offices may conduct a title examination of a tract...

  5. 24 CFR 207.258a - Title requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title requirements. 207.258a... the Contract of Insurance § 207.258a Title requirements. (a) Form of title evidence. The title... policy of title insurance, except that, if an abstract and attorney's opinion were accepted by...

  6. 24 CFR 203.386 - Coverage of title evidence.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Coverage of title evidence. 203.386... SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Property Title Transfers and Title Waivers § 203.386 Coverage of title evidence. Evidence of title shall be executed as of a date to...

  7. 32 CFR 644.63 - Contracting for title evidence.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Contracting for title evidence. 644.63 Section... PROPERTY REAL ESTATE HANDBOOK Acquisition Procurement of Title Evidence, Title Clearance, and Closings § 644.63 Contracting for title evidence. (a) Survey of Area and Source of Title...

  8. 32 CFR 644.69 - Title Clearance-Easements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Title Clearance-Easements. 644.69 Section 644.69... ESTATE HANDBOOK Acquisition Procurement of Title Evidence, Title Clearance, and Closings § 644.69 Title Clearance—Easements. (a) Easements Costing in Excess of $1,000. Curative action and clearance of title...

  9. 32 CFR 644.66 - Payment for title services.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Payment for title services. 644.66 Section 644.66... ESTATE HANDBOOK Acquisition Procurement of Title Evidence, Title Clearance, and Closings § 644.66 Payment for title services. (a) Approval. The Contracting Officer will approve payment for all title...

  10. 2 CFR 1.100 - Content of this title.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Content of this title. 1.100 Section 1.100 Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of this title. This title contains— (a) Office of Management...

  11. International Pediatric MS Study Group Global Members Symposium report.

    PubMed

    Wassmer, Evangeline; Chitnis, Tanuja; Pohl, Daniela; Amato, Maria Pia; Banwell, Brenda; Ghezzi, Angelo; Hintzen, Rogier Q; Krupp, Lauren B; Makhani, Naila; Rostásy, Kevin; Tardieu, Marc; Tenembaum, Silvia; Waldman, Amy; Waubant, Emmanuelle; Kornberg, Andrew J

    2016-08-30

    The International Pediatric Multiple Sclerosis Study Group held its inaugural educational program, "The World of Pediatric MS: A Global Update," in September 2014 to discuss advances and challenges in the diagnosis and management of pediatric multiple sclerosis (MS) and other neuroinflammatory CNS disorders. Highlights included a discussion on the revised diagnostic criteria, which enable the differentiation of MS, acute disseminated encephalomyelitis, neuromyelitis optica, and other neuroinflammatory disorders. While these criteria currently identify clinical and MRI features for a particular diagnosis, advances in biomarkers may prove to be useful in the future. An update was also provided on environmental factors associated with pediatric MS risk and possibly outcomes, notably vitamin D deficiency. However, optimal vitamin D intake and its role in altering MS course in children have yet to be established. Regarding MS outcomes, our understanding of the cognitive consequences of early-onset MS has grown. However, further work is needed to define the course of cognitive function and its long-term outcome in diverse patient samples and to develop strategies for effective cognitive rehabilitation specifically tailored to children and adolescents. Finally, treatment strategies were discussed, including a need to consider additional drug treatment options and paradigms (escalation vs induction), although treatment should be tailored to the individual child. Of critical importance, clinical trials of newer MS agents in children are required. Although our understanding of childhood MS has improved, further research is needed to have a positive impact for children and their families. PMID:27572855

  12. International Pediatric MS Study Group Global Members Symposium report.

    PubMed

    Wassmer, Evangeline; Chitnis, Tanuja; Pohl, Daniela; Amato, Maria Pia; Banwell, Brenda; Ghezzi, Angelo; Hintzen, Rogier Q; Krupp, Lauren B; Makhani, Naila; Rostásy, Kevin; Tardieu, Marc; Tenembaum, Silvia; Waldman, Amy; Waubant, Emmanuelle; Kornberg, Andrew J

    2016-08-30

    The International Pediatric Multiple Sclerosis Study Group held its inaugural educational program, "The World of Pediatric MS: A Global Update," in September 2014 to discuss advances and challenges in the diagnosis and management of pediatric multiple sclerosis (MS) and other neuroinflammatory CNS disorders. Highlights included a discussion on the revised diagnostic criteria, which enable the differentiation of MS, acute disseminated encephalomyelitis, neuromyelitis optica, and other neuroinflammatory disorders. While these criteria currently identify clinical and MRI features for a particular diagnosis, advances in biomarkers may prove to be useful in the future. An update was also provided on environmental factors associated with pediatric MS risk and possibly outcomes, notably vitamin D deficiency. However, optimal vitamin D intake and its role in altering MS course in children have yet to be established. Regarding MS outcomes, our understanding of the cognitive consequences of early-onset MS has grown. However, further work is needed to define the course of cognitive function and its long-term outcome in diverse patient samples and to develop strategies for effective cognitive rehabilitation specifically tailored to children and adolescents. Finally, treatment strategies were discussed, including a need to consider additional drug treatment options and paradigms (escalation vs induction), although treatment should be tailored to the individual child. Of critical importance, clinical trials of newer MS agents in children are required. Although our understanding of childhood MS has improved, further research is needed to have a positive impact for children and their families.

  13. Title III and toxic torts

    SciTech Connect

    Rodnehausen, G.A.

    1989-07-01

    In July the second annual Toxic Release Inventory (TRI) report under Section 313 of Title III of the Superfund Amendments and Reauthorization Act (SARA), and the computerized, national TRI data-base will be issued. Although the Environmental Protection Agency will not be able to aggregate the July, 1989 reports and issue its own annual report until early next year, we can expect political attention to focus quickly on whether total releases to air, land and water, and in particular total emissions to the air, have increased or decreased from 1987 to 1988. Because the reporting threshold for chemical manufacturing and processing facilities will drop from 75,000 to 50,000 pounds per year, the number of facilities reporting and number of chemicals reported should increase significantly, forcing up total releases. Bringing the totals down will be waste and release reduction efforts already underway in the chemical industry and elsewhere, and perhaps improved accuracy in measurement and estimation of releases. Additions to and deletions from the list of reportable chemicals will also have an effect. Nevertheless, any significant increase in aggregate totals, no matter what the explanation, will be bound to have a political impact on air toxics legislation, and spur public concern with the health risks of air pollution.

  14. Title I Achieving Schools Study

    ERIC Educational Resources Information Center

    Barela, Eric

    2008-01-01

    This article describes an educational program evaluation conducted by Dr. Eric Barela. Barela is a senior educational research analyst with the research and planning division of the Los Angeles Unified School District (LAUSD). He joined the division as an urban education research fellow and has been an internal evaluator with LAUSD for almost six…

  15. Dataset of mouse hippocampus profiled by LC-MS/MS for label-free quantitation.

    PubMed

    English, Jane A; Scaife, Caitriona; Harauma, Akiko; Focking, Melanie; Wynne, Kieran; Cagney, Gerard; Moriguchi, Toru; Cotter, David R

    2016-06-01

    This dataset reports on the analysis of mouse hippocampus by LC-MS/MS, from mice fed a diet that was either deficient in n-3 FA (n-3 Def) or sufficient in n-3 FA (n-3 Adq). Label free quantitative (LFQ) analysis of the mass spectrometry data identified 1008 quantifiable proteins, 115 of which were found to be differentially expressed between the two dietary groups (n=8 per group). This data article refers to the research article "Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus" (English et al., 2013 [1]), in which a more comprehensive interpretation and analysis of the data is given.

  16. Qualitative identification of rodenticide anticoagulants by LC-MS/MS.

    PubMed

    Middleberg, Robert A; Homan, Joseph

    2012-01-01

    Rodenticide anticoagulants are used in the control of rodent populations. In addition to accidental ingestions in humans, such agents have also been used for homicidal and suicidal purposes. There are two major groups of rodenticide anticoagulants - hydroxycoumarins and indanediones. Before the advent of LC-MS/MS, analysis for such agents was relegated to such techniques as TLC and HPLC with nonspecific modes of detection. LC-MS/MS has been used to determine any given number of rodenticide anticoagulants in animal tissues, foods, plasma, etc. Use of this technique allows for the simultaneous identification of individual compounds within both classes of rodenticide anticoagulants. The LC-MS/MS method presented allows for simultaneous qualitative identification of brodifacoum, bromadiolone, chlorphacinone, dicumarol, difenacoum, diphacinone, and warfarin in blood, serum, and plasma using ESI in the negative mode. Two transitions are monitored for each analyte after a simple sample preparation. Chromatographic separation is accomplished using a gradient of ammonium hydroxide in water and ammonium hydroxide in methanol. Chloro-warfarin is used as internal standard. PMID:22767114

  17. The advantage of short paper titles

    PubMed Central

    Letchford, Adrian; Moat, Helen Susannah; Preis, Tobias

    2015-01-01

    Vast numbers of scientific articles are published each year, some of which attract considerable attention, and some of which go almost unnoticed. Here, we investigate whether any of this variance can be explained by a simple metric of one aspect of the paper's presentation: the length of its title. Our analysis provides evidence that journals which publish papers with shorter titles receive more citations per paper. These results are consistent with the intriguing hypothesis that papers with shorter titles may be easier to understand, and hence attract more citations. PMID:26361556

  18. The collision of Title III and Title V: A potential permitting and enforcement nightmare

    SciTech Connect

    Facca, G.; Faler, M.

    1998-12-31

    The Clean Air Act of 1990 (CAA) mandated that all facilities classified as major were to obtain a Federal Title V operating permit. In addition, any facility, either major or minor, which emits certain chemicals or compounds above a specific single quantity limit or a total aggregate limit are subject to Title III requirements and are required to obtain a Title V permit as well. The problem with obtaining a Title V permit for Title III substances is there is limited data, at least for the utilities sources, on emission factors and emission rates for many of the Title III listed chemical compounds. In addition, the emission data that exists is very conservative, and if used, would show the facilities to be significant emitters of hazardous air emissions, while actual emissions are significantly less. This could lead a facility to applying for a Title V permit unnecessarily, a time consuming process at best. In Iowa, facilities submitted the first Title V permit applications in 1994. The Iowa Department of Natural Resources is currently in the process of reviewing the submittals prior to issuing operating permits. Title III has not been addressed at all in the submittals and therefore will not be included in this round of finished permits that are to be issued. The outcome of this is that the Title V permits will have to be opened and amended to include the applicable Title III operating conditions and constraints. This paper will examine the areas where Title III and Title V collide and the potential permitting and enforcement issues that will have to be faced by the facilities that operate under these permits. This paper is based on the opinions of two of the three responsible parties (facilities and consultants) that are dealing with the potential permitting and enforcement wreckage before the collision occurs.

  19. Assessing the Effectiveness of Education Interventions: Issues and Recommendations for the Title I Evaluation. MPR Reference No. 8911-700

    ERIC Educational Resources Information Center

    Glazerman, Steven; Myers, David

    2004-01-01

    In October 2002, the Institute of Education Sciences (IES) contracted with Mathematica Policy Research, Inc. (MRP) to help identify issues pertinent to the evaluation of Title I and to propose feasible evaluation design strategies. This design effort took its lead from two sources: (1) the Title I Independent Review Panel (IRP); and (2) a more…

  20. The Need for Conciliation under Title VII

    ERIC Educational Resources Information Center

    Pollard, William E.

    1975-01-01

    The AFL-CIO is committed to the task of eliminating discrimination and injustice in the workplace and is making efforts to expand the Equal Employment Opportunity Commission's conciliation efforts under Title Seven. (MW)

  1. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... provides survey coverage based on a survey acceptable to the title company and the Commissioner; or as the... Commissioner. (c) Endorsement of the credit instrument for insurance shall evidence the acceptability of...

  2. 24 CFR 200.61 - Title.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... provides survey coverage based on a survey acceptable to the title company and the Commissioner; or as the... Commissioner. (c) Endorsement of the credit instrument for insurance shall evidence the acceptability of...

  3. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., or other ship's materials shall not be considered Government-furnished property. (End of clause) ... (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (OCT 1994) (a) Unless...

  4. 48 CFR 1252.217-77 - Title.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., or other ship's materials shall not be considered Government-furnished property. (End of clause) ... (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (OCT 1994) (a) Unless...

  5. What every designated representative should know about Title IV and Title V enforcement provisions

    SciTech Connect

    Bischoff, C.A.; Dayal, P.

    1995-12-31

    Title IV of the Clean Air Act not only created a regulatory program unlike any other under the Clean Air Act, but also established a unique position--the designated representative--as an integral part of the program. The designated representative is required to meet certain basic obligations under Title IV, and a panoply of enforcement mechanisms are available to EPA in the event of noncompliance with these obligations. Also, because a designated representative may take on responsibilities under the permit provisions of Title V of the Clean Air Act, the designated representative can also be subject to an enforcement action for failure to comply with certain Title V permit requirements. This paper considers the basic definition of the designated representative under EPA`s Title IV and Title V regulations, identifies the responsibilities assigned to the designated representative, and then analyzes the enforcement mechanisms that may be applied to the designated representative if a regulatory responsibility has not been satisfied.

  6. Progressive MS Alliance Industry Forum: Maximizing Collective Impact To Enable Drug Development.

    PubMed

    Zaratin, P; Comi, G; Coetzee, T; Ramsey, K; Smith, K; Thompson, A; Panzara, M

    2016-10-01

    The Progressive MS Alliance Industry Forum describes a new approach to address barriers to developing treatments for progressive multiple sclerosis (MS). This innovative model promises to facilitate robust collaboration between industry, academia, and patient organizations and accelerate research towards the overarching goal of developing safe and effective treatments for progressive MS.

  7. Titles change the esthetic appreciations of paintings

    PubMed Central

    Gerger, Gernot; Leder, Helmut

    2015-01-01

    Esthetic experiences of artworks are influenced by contextualizing information such as titles. However, how titles contribute to positive esthetic experiences is still an open issue. Considering that fluency, as well as effortful elaborate processing, potentially influence esthetic experiences, we tested how three different title types—semantically matching (fluent), semantically non-matching (non-fluent), and an “untitled” condition (control)—affected experiences of abstract, semi-abstract, and representational art. While participants viewed title/artwork combinations we assessed facial electromygraphic (fEMG) recordings over M. corrugator supercilii and M. zygomaticus major muscle to capture subtle changes in emotional and cognitive processing, and asked for subjective liking and interest. Matching titles, but also the more effortful untitled condition, produced higher liking compared to non-fluently processed, non-matching titles especially in abstract art. These results were reflected in fEMG with stronger M. corrugator activations in the non-matching condition followed by the untitled condition. This implies high cognitive effort as well as negative emotions. Only in the matching condition, M. zygomaticus was more strongly activated indicating positive emotions due to fluency. Interest, however, was hardly affected. These results show that high levels of dis-fluency and cognitive effort reduce liking. However, fluency as well as moderate levels of effort contribute to more positive esthetic experiences. PMID:26379527

  8. [Research on the Content Characteristics and Pollution Evaluation of Heavy Metals in Filtered Water and Suspended Particles from Gansu, Ningxia and Inner Mongolia Sections of the Yellow River in Wet Season Using HR-ICP-MS].

    PubMed

    Ma, Xiao-ling; Liu, Jing-jun; Deng, Feng-yu; Zuo, Hang; Huang, Fang; Zhang, Li-yang; Liu, Ying

    2015-10-01

    The content characteristics, pollution evaluation and source identification of 6 heavy Metals (Cd, Pb, Cr, As, Cu and Zn) in filtered water and 9 heavy Metals (Cd, Pb, Cr, Ni, Cu, V, Co, Zn and Mn) in suspended particles from 10 sampling sites such as Zhaojunfuqiao (S1) and Baotoufuqiao (S2), etc. from Gansu, Ningxia and Inner Mongolia sections of the Yellow River in 2012 Wet Season were studied to understand the condition of the heavy metal pollution in Gansu, Ningxia and Inner Mongolia Sections of the Yellow River by using high resolution inductively coupled plasma-mass spectrometry (HR-ICP-MS). Multivariate geochemical approaches and statistical analysis were also exploited for assessing the level of heavy metals in filtered water and suspended particles from studied area. The results showed that in filtering water, only the concentrations of Cr exceeded the standard value of Environmental Quality Standard for Surface Water (GB3838-2002) and were the highest (74.8-94.7 μg x L(-1)) among all elements in 10 sampling sites; Single factor pollution index (I(i)) results suggested that the water quality in all sampling sites were contaminated by both Cr and total nitrogen (TN), with the exception of TN in Baotoufuqiao (S2); Integrated Nemerow pollution index (I) indicated that the I values in all sampling sites were between 1-2 (light pollution), which implied that the water quality in Gansu, Ningxia and Inner Mongolia sections, especially downstream sections (S1-S6) of the Yellow River wasn't an ideal source for drinking and using in aquaculture any more. In suspended particles, concentrations of heavy metals were relatively higher than their soil background values in 10 sampling sites, except Ni in S10 (34.7 μg x L(-1)). Index of geo-accumulation (I(geo)) indicated that the I(geo) values of Pb, Cr, Ni, Cu, V, Co, Zn and Mn in all sampling sites were less than 1 (unpolluted or unpolluted-moderately polluted), respectively, while I(geo)Cd were the highest in 10

  9. Quantitative performance of a quadrupole-orbitrap-MS in targeted LC-MS determinations of small molecules.

    PubMed

    Grund, Baptiste; Marvin, Laure; Rochat, Bertrand

    2016-05-30

    High-resolution mass spectrometry (HRMS) has been associated with qualitative and research analysis and QQQ-MS with quantitative and routine analysis. This view is now challenged and for this reason, we have evaluated the quantitative LC-MS performance of a new high-resolution mass spectrometer (HRMS), a Q-orbitrap-MS, and compared the results obtained with a recent triple-quadrupole MS (QQQ-MS). High-resolution full-scan (HR-FS) and MS/MS acquisitions have been tested with real plasma extracts or pure standards. Limits of detection, dynamic range, mass accuracy and false positive or false negative detections have been determined or investigated with protease inhibitors, tyrosine kinase inhibitors, steroids and metanephrines. Our quantitative results show that today's available HRMS are reliable and sensitive quantitative instruments and comparable to QQQ-MS quantitative performance. Taking into account their versatility, user-friendliness and robustness, we believe that HRMS should be seen more and more as key instruments in quantitative LC-MS analyses. In this scenario, most targeted LC-HRMS analyses should be performed by HR-FS recording virtually "all" ions. In addition to absolute quantifications, HR-FS will allow the relative quantifications of hundreds of metabolites in plasma revealing individual's metabolome and exposome. This phenotyping of known metabolites should promote HRMS in clinical environment. A few other LC-HRMS analyses should be performed in single-ion-monitoring or MS/MS mode when increased sensitivity and/or detection selectivity will be necessary.

  10. Public titles of clinical trials should have ethics review.

    PubMed

    Saenz, Carla; Reveiz, Ludovic; Tisdale, John F

    2015-09-01

    A key aspect to guarantee that research with human subjects is ethical is being overlooked. Ethics review committees invest great effort examining the informed consent documents of research protocols to ensure that potential participants can provide consent validly and are not deluded into thinking that the experimental intervention they may sign up for is already known to be therapeutic. However, these efforts to avoid what is called the "therapeutic misconception" might be in vain if the title with which the studies are being introduced to the potential participants escapes ethics review. Research participants might be deceived by clinical trials entitled "novel therapy" when the point of the trial is precisely to find out whether the intervention at stake is therapeutic or not. Providing potential research participants with such misleading information hampers their ability to make informed decisions. The well-established scrutiny that ethics review committees exercise with regard to consent forms is limited if the registration of clinical trials, for which a public title is chosen, constitutes a process that is independent from the ethics review. In this article, we examine this problem, assess recent measures to integrate clinical trial registration with ethics review processes, and provide specific recommendations to solve the problem and ultimately enhance the accountability, transparency, and ethics of research with human subjects.

  11. 12 CFR Appendix Ms-3 to Part 1024 - Appendix MS-3 to Part 1024

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Appendix MS-3 to Part 1024 MS Appendix MS-3 to... ACT (REGULATION X) Pt. 1024, App. MS-3 Appendix MS-3 to Part 1024 Model Force-Placed Insurance Notice Forms Table of Contents MS-3(A)—Model Form for Force-Placed Insurance Notice Containing...

  12. 29 CFR 452.7 - Bill of Rights, title I.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 2 2013-07-01 2013-07-01 false Bill of Rights, title I. 452.7 Section 452.7 Labor... DISCLOSURE ACT OF 1959 Other Provisions of the Act Affecting Title IV § 452.7 Bill of Rights, title I. The provisions of title I, “Bill of Rights of Members of Labor Organizations” 7 (particularly section...

  13. 29 CFR 452.7 - Bill of Rights, title I.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 2 2014-07-01 2014-07-01 false Bill of Rights, title I. 452.7 Section 452.7 Labor... DISCLOSURE ACT OF 1959 Other Provisions of the Act Affecting Title IV § 452.7 Bill of Rights, title I. The provisions of title I, “Bill of Rights of Members of Labor Organizations” 7 (particularly section...

  14. 29 CFR 452.7 - Bill of Rights, title I.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Bill of Rights, title I. 452.7 Section 452.7 Labor... DISCLOSURE ACT OF 1959 Other Provisions of the Act Affecting Title IV § 452.7 Bill of Rights, title I. The provisions of title I, “Bill of Rights of Members of Labor Organizations” 7 (particularly section...

  15. 29 CFR 452.7 - Bill of Rights, title I.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 2 2011-07-01 2011-07-01 false Bill of Rights, title I. 452.7 Section 452.7 Labor... DISCLOSURE ACT OF 1959 Other Provisions of the Act Affecting Title IV § 452.7 Bill of Rights, title I. The provisions of title I, “Bill of Rights of Members of Labor Organizations” 7 (particularly section...

  16. 24 CFR 203.366 - Conveyance of marketable title.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Conveyance of marketable title. 203... Conveyance of marketable title. (a) Satisfactory conveyance of title and transfer of possession. The mortgagee shall tender to the Commissioner a satisfactory conveyance of title and transfer of possession...

  17. 46 CFR 67.50 - Requirement for title evidence.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Requirement for title evidence. 67.50 Section 67.50... DOCUMENTATION OF VESSELS Title Requirements for Vessel Documentation § 67.50 Requirement for title evidence. The owner of a vessel must present title evidence in accordance with one of the methods specified in...

  18. 7 CFR 550.37 - Title to equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Title to equipment. 550.37 Section 550.37 Agriculture... Equipment/property Standards § 550.37 Title to equipment. (a) As authorized by 7 U.S.C. 3318(d), title to... provision of this rule the REE Agency may, at its discretion, retain title to equipment described...

  19. 48 CFR 1852.245-75 - Title to equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Title to equipment. 1852... 1852.245-75 Title to equipment. As prescribed in 1845.106-70(f), insert the following clause: Title to..., title to equipment and other tangible personal property acquired by the Contractor with funds...

  20. 29 CFR 452.8 - Trusteeship provisions, title III.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Trusteeship provisions, title III. 452.8 Section 452.8... AND DISCLOSURE ACT OF 1959 Other Provisions of the Act Affecting Title IV § 452.8 Trusteeship provisions, title III. Placing a labor organization under trusteeship consistent with title III, may have...

  1. 24 CFR 234.285 - Waived title objections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Waived title objections. 234.285... Waived title objections. The Commissioner shall not object to title by reason of the following matters... for a penalty of reversion or forfeiture of title or a lien for liquidated damage. (b) Easements...

  2. 24 CFR 232.595 - Eligibility of title.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Eligibility of title. 232.595... Fire Safety Equipment Title § 232.595 Eligibility of title. In order for the property which is to be... Commissioner shall determine that the title to the property is vested in the borrower as of the date...

  3. 32 CFR 644.65 - Ordering title evidence.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Ordering title evidence. 644.65 Section 644.65... ESTATE HANDBOOK Acquisition Procurement of Title Evidence, Title Clearance, and Closings § 644.65 Ordering title evidence. (a) Placing orders. Where the contract does not specify the order in which...

  4. 46 CFR 67.53 - Methods of establishing title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Methods of establishing title. 67.53 Section 67.53... DOCUMENTATION OF VESSELS Title Requirements for Vessel Documentation § 67.53 Methods of establishing title. Title to a vessel may be established through one of the following methods: (a) Simplified method...

  5. 48 CFR 32.503-14 - Protection of Government title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... title. 32.503-14 Section 32.503-14 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... of Government title. (a) Since the Progress Payments clause gives the Government title to all of the... ensure that the Government title to these inventories is not compromised by other...

  6. 29 CFR 2200.31 - Caption; titles of cases.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Caption; titles of cases. 2200.31 Section 2200.31 Labor... Pleadings and Motions § 2200.31 Caption; titles of cases. (a) Notice of contest cases. Cases initiated by a..., Respondent. (c) Location of title. The titles listed in paragraphs (a) and (b) of this section shall...

  7. MS-MS Approaches for the Analysis of Environmental Pollutants

    EPA Science Inventory

    Concern about the environment and the start of environmental analysis coincided with the rise of gas chromatography-mass spectrometry (GC-MS). The United States Environmental Protection Agency (U.S. EPA) was founded in 1970, and as the need for techniques to analyze environmental...

  8. Education and Title VI. Title VI of the Civil Rights Act of 1964.

    ERIC Educational Resources Information Center

    Office for Civil Rights (ED), Washington, DC.

    The Office for Civil Rights (OCR), in the U.S. Department of Education, is a law enforcement agency charged with enforcing the federal civil rights laws, one of which is Title VI of the Civil Rights Act of 1964. Title VI protects people from discrimination based on race, color, or national origin in programs or activities that receive federal…

  9. 25 CFR 150.11 - Disclosure of land records, title documents, and title reports.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... reports. (a) The usefulness of a Land Titles and Records Office depends in large measure on the ability of... grounds for denying access where such access is not required by the Freedom of Information Act, 5 U.S.C... disclosing information concerning any living individual, the Manager, Land Titles and Records Office,...

  10. Division of Federal Assistance Conference, Title I ESEA, Title II ESEA.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus.

    Speeches given at this conference cover the following areas: trends in implementation and funding status of Title I and Title II programs of the Elementary and Secondary Education Act; problems of designing programs for the urban disadvantaged (recruitment, curriculum development, staff selection, and supportive counseling); the cultures of rural…

  11. Roadmap Through Title XX. Financing Services for Children Through Title XX and Other Programs: Manual 5.

    ERIC Educational Resources Information Center

    Copeland, William C.; Iversen, Iver A.

    This manual, part of a Hecht Institute four-manual series entitled Financing Children's Services Through Title XX and Related Programs, teaches what Title XX regulations are, what they mean, and what actions and procedures are commanded by them. The first section covers the necessity of rule systems, the characteristics of a good rule system and…

  12. The Contrast Between Title I and Non-Title I Schools.

    ERIC Educational Resources Information Center

    Fortune, Jim C.; Hutchinson, Thomas E.

    The problem addressed in this paper is to compare the schools identified as participating in Title I, 1965 Elementary Secondary Education Act programs, with those identified as not participating in Title I, with regard to percentage of pupils on welfare, number of target group pupils, percentage of pupils reading below grade level, percentage of…

  13. HDX Workbench: Software for the Analysis of H/D Exchange MS Data

    NASA Astrophysics Data System (ADS)

    Pascal, Bruce D.; Willis, Scooter; Lauer, Janelle L.; Landgraf, Rachelle R.; West, Graham M.; Marciano, David; Novick, Scott; Goswami, Devrishi; Chalmers, Michael J.; Griffin, Patrick R.

    2012-09-01

    Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for the interrogation of protein conformation and dynamics. While the data analysis challenge of HDX-MS has been addressed by a number of software packages, new computational tools are needed to keep pace with the improved methods and throughput of this technique. To address these needs, we report an integrated desktop program titled HDX Workbench, which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets. Using the software, validated data analysis can be achieved at the rate of generation. The application is available at the project home page http://hdx.florida.scripps.edu.

  14. 10 years of MS instrumental developments--impact on LC-MS/MS in clinical chemistry.

    PubMed

    Himmelsbach, Markus

    2012-02-01

    The combination of liquid chromatography and mass spectrometry (LC-MS) is a powerful and indispensable analytical tool that is widely applied in many areas of chemistry, medicine, pharmaceutics and biochemistry. In this review recent MS instrumental developments are presented as part of a special issue covering various aspects of liquid chromatography tandem mass spectrometry (LC-MS/MS) in clinical chemistry. Improvements, new inventions as well as new combinations in ion source technology are described focusing on dual or multimode sources and atmospheric pressure photoionization (APPI). Increasing demands regarding sensitivity, accuracy, resolution and both quantitation and identification guarantee on-going improvements in mass analyzer technology. This paper discusses new hybrid MS instruments that can perform novel scan modes as well as high-resolution mass spectrometers (HRMS) that finally seem to be able to overcome, or at least significantly reduce, their weaknesses in quantitative applications. Ion mobility-mass spectrometry (IMMS) itself is not an invention of the last 10 years, but a lot of progress was made within the last decade that reveals the potential benefits of this combination. This is clearly reflected by the increased number of commercially available instruments and the various designs of IMMS are covered in detail in this review. Selected applications for all these instrumental developments are given focusing on the perspective of clinical chemistry.

  15. Covert Operation ``Sun God'' - History of German Solar Research in the Third Reich and Under Allied Occupation (German Title: Kommandosache ``Sonnengott'' - Geschichte der deutschen Sonnenforschung im Dritten Reich und unter alliierter Besatzung)

    NASA Astrophysics Data System (ADS)

    Seiler, Michael P.

    Between 1939 and 1945 the Luftwaffe of the Third Reich invested large sums in solar research and the establishment of a chain of solar observatories under the code word “Sun God”. Observations of the different phenomena of solar activity were intended to allow a dependable daily prediction of the best frequency bands for long-range military radio. For the development of these research activities the Luftwaffe used a young astrophysicist, who - being the son of a well-known leftist publisher of the Weimar Republic - did appear not well suited to perform “war decisive research” for the Nazi regime: Karl-Otto Kiepenheuer (1910-1975). Circumventing the usual academic tenure, Hitler's war turned the barely thirty-year-old and up to then rather unsuccessful Kiepenheuer into an influential director of a research institution, which he was to remain for the next three decades as well. This book recounts the history of German solar research in the period 1939-1949, her entanglement with the crimes of the Nazi regime as well as her use by the Western Allies until the founding of the German Federal Republic.

  16. Future directions of imaging MS in pharmaceutical R&D.

    PubMed

    Goodwin, Richard J A; Webborn, Peter J H

    2015-01-01

    MS imaging has rapidly evolved over the last decade, finding roles in all aspects of pharmaceutical research and development. This article discusses possible methodological and technological future advancements and describes research areas where the technology can expand and continue to prove to be worthwhile tool for drug discovery and development. PMID:26510897

  17. Quantitative determination of fluorotelomer sulfonates in groundwater by LC MS/MS.

    PubMed

    Schultz, Melissa M; Barofsky, Douglas F; Field, Jennifer A

    2004-03-15

    Aqueous film-forming foams (AFFF) are complex mixtures containing fluorocarbon- and hydrocarbon-based surfactants that are used to fight hydrocarbon-fueled fires. The military is the largest consumer of AFFF in the United States, and fire-training activities conducted at military bases have led to groundwater contamination by unspent fuels and AFFF chemicals. A direct-injection, liquid-chromatography tandem mass spectrometry (LC MS/MS) method was developed to quantify a suite of fluorotelomer sulfonate surfactants in groundwater collected from military bases where fire-training activities were conducted. The 4:2, 6:2, and 8:2 fluorotelomer sulfonates were detected and quantified in groundwater from two of the three military bases. The total fluorotelomer sulfonate concentrations observed at Wurtsmith AFB, MI, and Tyndall AFB, FL, ranged respectively from below quantitation (< or = 0.60) to 182 microg/L and from 1100 to 14,600 microg/L. Analyses of a fluorotelomer-based AFFF concentrate by negative ion fast atom bombardment/mass spectrometry and LC MS/MS analyses indicate that the AFFF concentrate contains only a small amount of fluorotelomer sulfonates and that fluoroalkylthioamido sulfonates are the main anionic fluorosurfactant in the mixtures. More research is needed to determine the fate of fluoroalkylthioamido sulfonates in the environment.

  18. Determination of Dextromethorphan in Oral Fluid by LC-MS-MS.

    PubMed

    Amaratunga, Piyadarsha; Clothier, Morgan; Lorenz Lemberg, Bridget; Lemberg, Dave

    2016-06-01

    Dextromethorphan (DXM) is an antitussive drug found in commonly used nonprescription cold and cough medications. At low doses, DXM is a safe drug that does not produce adverse reactions. However, abuse of DXM has been reported among adolescents and young adults using the drug at higher doses. DXM is not a scheduled drug in the USA, and the primary reason for its abuse is the ease of availability. DXM is available to purchase in the form of over-the-counter cough medications, such as Robitussin(®) and Coricidin(®), or it can be purchased over the Internet in the form of a powder. In this research work, we developed an LC-MS-MS method that can quantify DXM and dextrorphan (DXO) in oral fluid in a high-throughput toxicology laboratory setting. The developed method was validated according to the Scientific Working Group for Forensic Toxicology guidelines. The linear dynamic range was 5-100 ng/mL with a lowest limit of quantitation (LLOQ) of 5.0 ng/mL for DXM and DXO. Overall, the results of the accuracy and the precision values were within the acceptance criteria for both drugs. In addition, selectivity, matrix effect and recovery were calculated for the LC-MS-MS method. Authentic samples (n = 59) were tested to evaluate the applicability of the method. Thirty samples were found to be positive for DXM and DXO and two samples were found to be positive for DXM only.

  19. Evaluation of the Effectiveness of Compensatory Education Funded by Title I, ESEA.

    ERIC Educational Resources Information Center

    Gordon, Kenneth F.; Gordon, Barbara, J. A.

    During 1967 and 1968, TEMPO, a Research affiliate of The General Electric Company, evaluated federal assistance to local school districts to use for compensatory education authorized by 1965 Elementary Secondary Education Act Title I. The specific research questions were straight-forward: (1) Has statistically significant enhancement of pupil…

  20. The preparation for and survival of an EPA Title IV and Title V facility audit

    SciTech Connect

    Facca, G.L.; Faler, M.

    1999-07-01

    As part of the 1990 Clean Air Act Amendments, major facilities are required to obtain federally enforceable operating permits (Title V). In a separate permitting action, the electric utilities with units generating more then 25 megawatts are required to obtain permits for NO{sub x} and SO{sub x}, the emissions which contribute to acid rain (Title IV). The Title IV permit is included as part of the Title V permit. This paper will use an actual audit experience at a coal fired generation facility as a case study for the preparation for and outcome of an EPA Title IV Level 3 audit. The paper will document the procedures for preparation, the audit process, and the outcome. The audit is part of the EPA's process for review of the record keeping and instrument calibration methods outlined in Title IV. Both types of permits have many different record keeping and monitoring requirements as well as separate reporting requirements which are submitted to both federal; state and local regulatory agencies for review and evaluation. Title IV units include very specific instrument calibration/audit requirements, and Title V has compliance testing and monitoring requirements. Alliant Power was notified in August 1998 of the intent of EPA Region VII to conduct a Level 3 audit at the Lansing Generation Station. The US EPA and the State of Iowa intended to review all Title IV record keeping (Level 1), continuous emission monitoring calibrations and linearity testing (Level 2) and observe the annual Relative Accuracy Testing Audit performed by an outside contractor. In addition, during this facility site visit, the compliance with Title V permit requirements was also audited.

  1. Towards establishing MS prevalence in Latin America and the Caribbean.

    PubMed

    Melcon, M O; Melcon, C M; Bartoloni, L; Cristiano, E; Duran, J C; Grzesiuk, A K; Fragoso, Y D; Brooks, J B Bidin; Díaz, V; Romero García, K M; Cabrera Gomez, J A; Abad, P; Islas, M A Macías; Gracia, F; Diaz de Bedoya, V F Hamuy; Ruiz, M E Córdova; Hackembruch, J H; Oehninger, C; Ketzoian, C N; Soto, A

    2013-02-01

    A very high prevalence of multiple sclerosis (MS) has been reported in some Western European and North American countries. The few surveys of MS epidemiology in South America reveal lower prevalence rates, implying that susceptibility varies between distinct ethnic groups, thus forming an important determinant of the geographic distribution of the disease. The objective of this study is to review MS prevalence estimates in different Latin American and Caribbean countries. We reviewed surveys of regional MS prevalence from 1991 to 2011. Sources included an online database, authors' reports and proceedings or specific lectures from regional conferences. We obtained a total of 30 prevalence surveys from 15 countries, showing low/medium MS prevalence rates. Both the number and the quality of prevalence surveys have greatly improved in this region over recent decades. This is the first collaborative study to map the regional frequency of MS. Establishment of standardized methods and joint epidemiological studies will advance future MS research in Latin America and the Caribbean.

  2. Title List of documents made publicly available

    SciTech Connect

    Not Available

    1982-07-01

    The Title List of Documents Made Publicly Available is a monthly publication. It contains descriptions of the information received and generated by the US Nuclear Regulatory Commission (NRC). This information includes: (1) docketed material associated with civilian nuclear power plants and other uses of radioactive materials and (2) nondocketed material received and generated by NRC pertinent to its role as a regulatory agency. As used here, docketed does not refer to Court dockets; it refers to the system by which NRC maintains its regulatory records. This series of documents is indexed by a Personal Author Index, a Corporate Source Index, and a Report Number Index. The docketed information contained in the Title List includes the information formerly issued through the Department of Energy publication Power Reactor Docket Information, last published in January 1979. Microfiche of the docketed information listed in the Title List is available for sale on a subscription basis from the National Technical Information Service (NTIS).

  3. Title List of documents made publicly available

    SciTech Connect

    Not Available

    1982-06-01

    The Title List of Documents Made Publicly Available is a monthly publication. It contains descriptions of the information received and generated by the US Nuclear Regulatory Commission (NRC). This information includes: (1) docketed material associated with civilian nuclear power plants and other uses of radioactive materials and (2) nondocketed material received and generated by NRC pertinent to its role as a regulatory agency. As used here, docketed does not refer to Court dockets; it refers to the system by which NRC maintains its regulatory records. This series of documents is indexed by a Personal Author Index, a Corporate Source Index, and a Report Number Index. The docketed information contained in the Title List includes the information formerly issued throught the Department of Energy publication Power Reactor Docket Information, last published in January 1979. Microfiche of the docketed information listed in the Title List is available for sale on a subscription basis from the National Technical Information Service (NTIS).

  4. Phosphoprotein profiling by PA-GeLC-MS/MS.

    PubMed

    Kristjansdottir, Kolbrun; Wolfgeher, Donald; Lucius, Nick; Angulo, David Sigfredo; Kron, Stephen J

    2008-07-01

    A significant consequence of protein phosphorylation is to alter protein-protein interactions, leading to dynamic regulation of the components of protein complexes that direct many core biological processes. Recent proteomic studies have populated databases with extensive compilations of cellular phosphoproteins and phosphorylation sites and a similarly deep coverage of the subunit compositions and interactions in multiprotein complexes. However, considerably less data are available on the dynamics of phosphorylation, composition of multiprotein complexes or that define their interdependence. We describe a method to identify candidate phosphoprotein complexes by combining phosphoprotein affinity chromatography, separation by size, denaturing gel electrophoresis, protein identification by tandem mass spectrometry, and informatics analysis. Toward developing phosphoproteome profiling, we have isolated native phosphoproteins using a phosphoprotein affinity matrix, Pro-Q Diamond resin (Molecular Probes-Invitrogen). This resin quantitatively retains phosphoproteins and associated proteins from cell extracts. Pro-Q Diamond purification of a yeast whole cell extract followed by 1-D PAGE separation, proteolysis and ESI LC-MS/MS, a method we term PA-GeLC-MS/MS, yielded 108 proteins, a majority of which were known phosphoproteins. To identify proteins that were purified as parts of phosphoprotein complexes, the Pro-Q eluate was separated into two fractions by size, <100 kDa and >100 kDa, before analysis by PAGE and ESI LC-MS/MS and the component proteins queried against databases to identify protein-protein interactions. The <100 kDa fraction was enriched in phosphoproteins indicating the presence of monomeric phosphoproteins. The >100 kDa fraction contained 171 proteins of 20-80 kDa, nearly all of which participate in known protein-protein interactions. Of these 171, few are known phosphoproteins, consistent with their purification by participation in protein complexes. By

  5. Evaluating GC/MS Performance

    SciTech Connect

    Alcaraz, A; Dougan, A

    2006-11-26

    Evaluating the chemical background in the GC/MS system (system background) and solvent purity. This procedure will allow the analyst to verify that the GC/MS is free of chemical interferences or contamination and verify the solvent being utilized is free of interferences - Conduct a GC/MS analysis without injecting a solvent (system background) and Conduct a GC/MS analysis inject 1uL of CH2Cl2 solvent (Solvent background). GC conditions: (1) Injector Temperature (C): Injector Temperature is typically set at 250; (2) Transferline Temperature (C) - The Transferline Temperature is typically set at 280 C; (3) Constant flow (Sec./cm2) - This value, in seconds per cubic cm. Typically, set at 32; (4) Splitless mode (Sec.) - This value, in seconds, is the time before the purge valve opens. Typically, set at 45 seconds; (5) Starting Temperature (C): The Starting Temperature value can be set at 40 C; (6) Hold Time 1 (Min.) - Hold Time 1 is the amount of time, in minutes at the Starting Temperature that Ramp 1 Temperature is held. Typically set at 3 minutes; (7) Ramp 1 Rate (C/Min.) - Ramp 1 Rate is the temperature rise per unit time and has a typically value of 8 C per minute to 300 C; and (8) Hold Time 2 (Min.): Hold Time 2 is the amount of time, in minutes at the final Temperature that Ramp 1 Temperature is held. Temperature is held at 300 C for 3 minutes. MS conditions: Electronic - 40 to 500 amu, Scan Range - 30-600 m/z, Scan time - 0.7 sec, Mass Resolution - 07u, and Electron energy 1 - 70 eV. The total ion chromatograms (TIC) from a bakeout and solvent should be void of any large chromatographic peaks (see figure 1). Autotune using the PFTBA calibrant: First selecting the autotune option and click on standard autotune. The software program will generate final tune report similar to figure 2. If there are any MS tuning problems (e.g., dirty source, air leak, etc.) the tuning process will fail. Be sure to save the tune file before proceeding to the next step. Run an 'Air

  6. Civil Rights: Civil Rights Act of 1964 (Amended 1972, 1975, 1978), Title VI, Title VII [and] Educational Amendments of 1972, Title IX. Legal Modules for Vocational Cooperative Education.

    ERIC Educational Resources Information Center

    Western Michigan Univ., Kalamazoo.

    This module deals with various state and federal legislation pertaining to the civil rights of students enrolled in vocational cooperative programs in Michigan. Covered in the module are Title VI and Title VII of the Civil Rights Act of 1964 and Title IX of the Education Amendments of 1972 as well as Michigan civil rights legislation. The module,…

  7. 20 CFR 416.573 - How much will we withhold from your title II and title VIII benefits to recover a title XVI...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How much will we withhold from your title II and title VIII benefits to recover a title XVI overpayment? 416.573 Section 416.573 Employees... Payment of Benefits, Overpayments, and Underpayments § 416.573 How much will we withhold from your...

  8. 20 CFR 416.573 - How much will we withhold from your title II and title VIII benefits to recover a title XVI...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false How much will we withhold from your title II and title VIII benefits to recover a title XVI overpayment? 416.573 Section 416.573 Employees... Payment of Benefits, Overpayments, and Underpayments § 416.573 How much will we withhold from your...

  9. Determination of drugs in hair using GC/MS/MS.

    PubMed

    Uhl, M

    1997-01-17

    An important task for the forensic toxicologist and expert witness is the detection of the noxa in biological matrices. Because of this, the identification and quantification of residues of illegal drugs in human hair is still of growing interest. Utilizing the advantages of GC/MS/MS testing human hair is performed for most common drugs of abuse like heroin and other opioides, cocaine, cannabis and amphetamine derivatives. Analyzing hair specimens for substances that present a toxicological risk is another challenge. Several quality control parameters must be observed to avoid false positive or false negative results and to gain additional information. Blank sample, blank hair as well as the combined wash extracts are tested for the presence of the relevant compounds within every series. Careful evaluation of the findings can provide an approximate measure of the intensity of drug use in the majority of cases.

  10. Therapeutic drug monitoring of tamoxifen using LC-MS/MS.

    PubMed

    Tchu, Simone M; Lynch, Kara L; Wu, Alan H B

    2012-01-01

    Tamoxifen is a selective estrogen receptor modulator (SERM) that is used widely in the treatment of estrogen receptor positive breast cancer (ER+). Therapeutic monitoring of tamoxifen, and its metabolites N-desmethyltamoxifen (NDTam) and 4-hydroxy-N-desmethyltamoxifen (endoxifen), may be clinically useful for guiding treatment decisions. Two significant barriers to tamoxifen efficacy are: (1) variability in conversion of tamoxifen into the potent antiestrogenic metabolite, endoxifen, and (2) poor compliance and adherence to tamoxifen therapy. Therapeutic monitoring can be used to address both of these issues. Low levels of endoxifen indicate either poor compliance or poor metabolism of tamoxifen. Low tamoxifen levels would suggest poor compliance while a low ratio of endoxifen to NDTam would be indicative of poor metabolism. Solid phase extraction of patient serum followed by liquid chromatography tandem mass spectrometry (LC-MS/MS) detection enables rapid, accurate, detection of tamoxifen, N-desmethyltamoxifen, and endoxifen. PMID:22767121

  11. ESEA Title I: Instructional Aides Program.

    ERIC Educational Resources Information Center

    Lile, Kurt; And Others

    The Title I Program in the Fremont Unified School District is located at two target schools. Currently there are 39 instructional aides employed. Aides were recruited through letters to parents and notices on shopping center bulletin boards in the target area. A committee including the principals of the two schools, the resource teachers, and a…

  12. Feminizing Science: The Alchemy of Title IX

    ERIC Educational Resources Information Center

    Hausman, Patricia

    2008-01-01

    The author scrutinizes the National Academy of Sciences report "Beyond Bias and Barriers: Fulfilling the Potential of Women in Academic Science and Engineering" and its dangerous call to place the sciences under the sledgehammer of Title IX. Her findings: A one-sided, inaccurate, and internally contradictory report prepared by a committee lacking…

  13. 24 CFR 241.600 - Title evidence.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Title evidence. 241.600 Section 241.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN...

  14. Training Manual: Dictionary of Occupational Titles.

    ERIC Educational Resources Information Center

    Georgia State Dept. of Human Resources, Atlanta.

    The training manual was developed as a tool for understanding the occupational information and descriptive data presented in the Dictionary of Occupational Titles (DOT) (Volumes 1 and 2 and Supplements 1 and 2). Exercises are provided in workbook form to increase an understanding of the occupational information presented. Exercises coordinated…

  15. Review the draft Title V with care

    SciTech Connect

    Romzick, P.G.; Heitz, D.R.

    1998-12-31

    The Title V permitting process is well underway for many industries and just beginning for others. Waste Management recently conducted the first in-depth reviews of draft Title V permits for some of its municipal solid waste (MSW) landfills. The Company`s comments on the draft permits were numerous. The draft permits contained some obvious as well as several less obvious errors. The results of these reviews identified a need to scrutinize carefully each and every draft permit issued to the Company`s landfills. The Company expects to require Title V permits for most of its 140 plus active landfills, due to the recently-enacted New Source Performance Standards for Municipal Solid Waste Landfills. Many issues of concern were encountered during the review. Had these issues not been identified, the facility would have had to live with an unnecessarily burdensome permit consisting of permit conditions that were more strict than the regulations required and lacking protections allowed by the law. This paper discusses many of the issues of concern identified during the draft permit review. Although many of the issues addressed in this paper are specific to MSW landfills, many of the issues are also applicable to Title V permits in general.

  16. Title I: Time to Get It Right

    ERIC Educational Resources Information Center

    Roza, Marguerite; Lake, Robin

    2015-01-01

    Congress enacted the Elementary and Secondary Education Act (ESEA) 50 years ago as part of President Lyndon B. Johnson's "War on Poverty." The most expansive federal education bill ever passed, it was developed as redress, establishing that poor children needed more educational services than wealthier children. Title I of the ESEA…

  17. 24 CFR 241.600 - Title evidence.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Title evidence. 241.600 Section 241.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN...

  18. 24 CFR 241.600 - Title evidence.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Title evidence. 241.600 Section 241.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN...

  19. Monitoring Services to Children: Title XX

    ERIC Educational Resources Information Center

    Black Child Development Institute

    1977-01-01

    The proliferation of State offices of child development and the advent of Social Security Title XX funds have been accompanied by confusion at every level of government and in the black community. The impact of these developments on availability of good day care for children is examined and recommendations are made. (Author/AM)

  20. 24 CFR 3500.16 - Title companies.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Title companies. 3500.16 Section 3500.16 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND......

  1. ESEA Title III 1972 - PACE in Pennsylvania.

    ERIC Educational Resources Information Center

    Research and Information Services for Education, King of Prussia, PA.

    This document is a collection of abstracts of all ESEA Title III educational innovation projects funded or operating in Pennsylvania during 1972. Each abstract contains the name of the local supporting agency, the project number, financial information, target population, major objectives, activities, evaluation design, findings to date,…

  2. Multicultural Titles for Holidays and Celebrations.

    ERIC Educational Resources Information Center

    Mitchell-Powell, Brenda

    1993-01-01

    This bibliography (14 sources) of holiday-oriented titles provides resources for school, library, and home use that present engaging perspectives on cultural celebrations, informative content, and potential for interactive use. All incorporate diversity as an everyday way of life rather than a special occasion posture. (SLD)

  3. 24 CFR 241.600 - Title evidence.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Title evidence. 241.600 Section 241.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN...

  4. 7 CFR 1955.141 - Transferring title.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... or place project operations on a sound basis. 7 CFR part 3560, subpart E will be followed in... granted to program applicants purchasing MFH properties in accordance with the provisions of 7 CFR part... 7 Agriculture 14 2010-01-01 2009-01-01 true Transferring title. 1955.141 Section...

  5. Title V in South Carolina -- An Update.

    ERIC Educational Resources Information Center

    Jacob, Nelson L.

    Since South Carolina's Title V Community and Resource Development (CRD) project is limited to one small rural county (Williamsburg) affording careful documentation, this paper explicates South Carolina's CRD process via a social action model. This project, then, is described in terms of the following model components: (1) community initiative…

  6. 12 CFR Appendix Ms-1 to Part 1024 - Appendix MS-1 to Part 1024

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Appendix MS-1 to Part 1024 MS Appendix MS-1 to Part 1024 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION REAL ESTATE SETTLEMENT PROCEDURES ACT (REGULATION X) Pt. 1024, App. MS-1 Appendix MS-1 to Part 1024 SERVICING DISCLOSURE...

  7. 24 CFR Appendix Ms-1 to Part 3500 - Appendix MS-1 to Part 3500

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Appendix MS-1 to Part 3500 MS Appendix MS-1 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-1 Appendix MS-1...

  8. 24 CFR Appendix Ms-1 to Part 3500 - Appendix MS-1 to Part 3500

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Appendix MS-1 to Part 3500 MS Appendix MS-1 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-1 Appendix MS-1...

  9. 24 CFR Appendix Ms-1 to Part 3500 - Appendix MS-1 to Part 3500

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Appendix MS-1 to Part 3500 MS Appendix MS-1 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-1 Appendix MS-1...

  10. 24 CFR Appendix Ms-2 to Part 3500 - Appendix MS-2 to Part 3500

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Appendix MS-2 to Part 3500 MS Appendix MS-2 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-2 Appendix MS-2...

  11. 24 CFR Appendix Ms-2 to Part 3500 - Appendix MS-2 to Part 3500

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Appendix MS-2 to Part 3500 MS Appendix MS-2 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-2 Appendix MS-2...

  12. 24 CFR Appendix Ms-2 to Part 3500 - Appendix MS-2 to Part 3500

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Appendix MS-2 to Part 3500 MS Appendix MS-2 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-2 Appendix MS-2...

  13. 24 CFR Appendix Ms-1 to Part 3500 - Appendix MS-1 to Part 3500

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Appendix MS-1 to Part 3500 MS Appendix MS-1 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-1 Appendix MS-1...

  14. 24 CFR Appendix Ms-1 to Part 3500 - Appendix MS-1 to Part 3500

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Appendix MS-1 to Part 3500 MS Appendix MS-1 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-1 Appendix MS-1...

  15. 24 CFR Appendix Ms-2 to Part 3500 - Appendix MS-2 to Part 3500

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Appendix MS-2 to Part 3500 MS Appendix MS-2 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-2 Appendix MS-2...

  16. 24 CFR Appendix Ms-2 to Part 3500 - Appendix MS-2 to Part 3500

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Appendix MS-2 to Part 3500 MS Appendix MS-2 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-2 Appendix MS-2...

  17. Dataset of mouse hippocampus profiled by LC-MS/MS for label-free quantitation.

    PubMed

    English, Jane A; Scaife, Caitriona; Harauma, Akiko; Focking, Melanie; Wynne, Kieran; Cagney, Gerard; Moriguchi, Toru; Cotter, David R

    2016-06-01

    This dataset reports on the analysis of mouse hippocampus by LC-MS/MS, from mice fed a diet that was either deficient in n-3 FA (n-3 Def) or sufficient in n-3 FA (n-3 Adq). Label free quantitative (LFQ) analysis of the mass spectrometry data identified 1008 quantifiable proteins, 115 of which were found to be differentially expressed between the two dietary groups (n=8 per group). This data article refers to the research article "Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus" (English et al., 2013 [1]), in which a more comprehensive interpretation and analysis of the data is given. PMID:26977433

  18. Comparison of clozapine in nail and hair of psychiatric patients determined with LC-MS/MS.

    PubMed

    Chen, Hang; Xiang, Ping; Sun, Qi-Ran; Shen, Min

    2012-09-01

    As a keratinized material, nail recently has attracting researchers' attention in the pharmaceuticals analysis. There are comparatively limited studies concerning nail's xenobiotic determination and its mechanism. This article reported the development of a sensitive, specific and reproducible LC-MS/MS method, which could be as a foundation of other studies on drug determination in nail. It can also be regarded as the first report on organic drug in mainland China. Sixteen nail samples from volunteers, who were ingested clozapine for more than nine months, are confirmed positive after being analyzed by the method. It is found that contents of clozapine in the patients' nails are above the nanogram level. Besides, a comparative study of clozapine concentration in nails and hair was made, with a result that there exists a correlation between the two materials in terms of clozapine concentration. PMID:23227550

  19. ms2: A molecular simulation tool for thermodynamic properties

    NASA Astrophysics Data System (ADS)

    Deublein, Stephan; Eckl, Bernhard; Stoll, Jürgen; Lishchuk, Sergey V.; Guevara-Carrion, Gabriela; Glass, Colin W.; Merker, Thorsten; Bernreuther, Martin; Hasse, Hans; Vrabec, Jadran

    2011-11-01

    This work presents the molecular simulation program ms2 that is designed for the calculation of thermodynamic properties of bulk fluids in equilibrium consisting of small electro-neutral molecules. ms2 features the two main molecular simulation techniques, molecular dynamics (MD) and Monte-Carlo. It supports the calculation of vapor-liquid equilibria of pure fluids and multi-component mixtures described by rigid molecular models on the basis of the grand equilibrium method. Furthermore, it is capable of sampling various classical ensembles and yields numerous thermodynamic properties. To evaluate the chemical potential, Widom's test molecule method and gradual insertion are implemented. Transport properties are determined by equilibrium MD simulations following the Green-Kubo formalism. ms2 is designed to meet the requirements of academia and industry, particularly achieving short response times and straightforward handling. It is written in Fortran90 and optimized for a fast execution on a broad range of computer architectures, spanning from single processor PCs over PC-clusters and vector computers to high-end parallel machines. The standard Message Passing Interface (MPI) is used for parallelization and ms2 is therefore easily portable to different computing platforms. Feature tools facilitate the interaction with the code and the interpretation of input and output files. The accuracy and reliability of ms2 has been shown for a large variety of fluids in preceding work. Program summaryProgram title:ms2 Catalogue identifier: AEJF_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEJF_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Special Licence supplied by the authors No. of lines in distributed program, including test data, etc.: 82 794 No. of bytes in distributed program, including test data, etc.: 793 705 Distribution format: tar.gz Programming language: Fortran90 Computer: The

  20. Analysis of 136 pesticides in avocado using a modified QuEChERS method with LC-MS/MS and GC-MS/MS.

    PubMed

    Chamkasem, Narong; Ollis, Lisa W; Harmon, Tiffany; Lee, Sookwang; Mercer, Greg

    2013-03-13

    A simple and high-throughput screening method for the analysis of 136 pesticides in avocado ( Persea americana ) by LC-(+)-ESI-MS/MS and GC-MS/MS is presented. A modified QuEChERS sample preparation method was developed to improve the extraction recovery of highly lipophilic pesticides. Extracts from minced avocados after acetonitrile (MeCN) extraction were directly injected to LC-MS/MS, whereas other GC-amenable compounds were treated with the modified QuEChERS procedure for GC-MS/MS analysis. The average recoveries for 79 pesticides quantified by LC-MS/MS at 10, 50, and 200 ng/g fortifying levels were 86.1% or better (with maximum RSD at 9.2%), whereas GC-MS/MS analysis demonstrated 70.2% or better (RSD < 18%) for average recovery from 57 compounds at the same spike levels. The application of LC- and GC-MS/MS combined with the improved extraction procedures led to the current method, which can quantitate these pesticides even if they are present in avocados below the targeted action level by FDA. This method demonstrated the improved recovery of several challenging lipophilic pesticides in highly fat-rich avocados. PMID:23362971

  1. PTR-MS in enology

    NASA Astrophysics Data System (ADS)

    Spitaler, Renate; Araghipour, Nooshin; Mikoviny, Tomas; Wisthaler, Armin; Via, Josef Dalla; Märk, Tilmann D.

    2007-10-01

    The present communication deals with the improvement of proton transfer reaction mass spectrometry (PTR-MS) wine headspace analyses. In contrast to previous PTR-MS investigations of wine, where wine headspace was ionized by protonated ethanol clusters, the headspace was diluted by a factor of 1:40 with N2 and ionized by H3O+ ions. This method is better suited for routine applications than the previously reported method since it is simpler, faster, and the mass spectra obtained are less complex. A test wine was mixed with ethanol and with water to yield ethanol contents ranging from 10 to 15% (v/v) and these mixtures were analyzed to assess whether any quantitative differences in the composition of volatiles were detectable. The data showed no impact of the ethanol content on the wine headspace composition. The new method was applied to eight different wine samples produced from two different grape varieties: Pinot Noir and Cabernet Sauvignon. Each variety was grown in two different locations in South Tyrol (Northern Italy) and harvested at two different dates. Quantitative (but not qualitative) differences in PTR-MS spectra between the two wine varieties were observed. Using principal component analysis of selected m/z signals differentiation between Pinot Noir and Cabernet Sauvignon samples was achievable.

  2. The search for cognitive terminology: an analysis of comparative psychology journal titles.

    PubMed

    Whissell, Cynthia; Abramson, Charles I; Barber, Kelsey R

    2013-03-01

    This research examines the employment of cognitive or mentalist words in the titles of articles from three comparative psychology journals (Journal of Comparative Psychology, International Journal of Comparative Psychology, Journal of Experimental Psychology: Animal Behavior Processes; 8,572 titles, >100,000 words). The Dictionary of Affect in Language, coupled with a word search of titles, was employed to demonstrate cognitive creep. The use of cognitive terminology increased over time (1940-2010) and the increase was especially notable in comparison to the use of behavioral words, highlighting a progressively cognitivist approach to comparative research. Problems associated with the use of cognitive terminology in this domain include a lack of operationalization and a lack of portability. There were stylistic differences among journals including an increased use of words rated as pleasant and concrete across years for Journal of Comparative Psychology, and a greater use of emotionally unpleasant and concrete words in Journal of Experimental Psychology: Animal Behavior Processes. PMID:25379230

  3. The Search for Cognitive Terminology: An Analysis of Comparative Psychology Journal Titles

    PubMed Central

    Whissell, Cynthia; Abramson, Charles I.; Barber, Kelsey R.

    2013-01-01

    This research examines the employment of cognitive or mentalist words in the titles of articles from three comparative psychology journals (Journal of Comparative Psychology, International Journal of Comparative Psychology, Journal of Experimental Psychology: Animal Behavior Processes; 8,572 titles, >100,000 words). The Dictionary of Affect in Language, coupled with a word search of titles, was employed to demonstrate cognitive creep. The use of cognitive terminology increased over time (1940–2010) and the increase was especially notable in comparison to the use of behavioral words, highlighting a progressively cognitivist approach to comparative research. Problems associated with the use of cognitive terminology in this domain include a lack of operationalization and a lack of portability. There were stylistic differences among journals including an increased use of words rated as pleasant and concrete across years for Journal of Comparative Psychology, and a greater use of emotionally unpleasant and concrete words in Journal of Experimental Psychology: Animal Behavior Processes. PMID:25379230

  4. The search for cognitive terminology: an analysis of comparative psychology journal titles.

    PubMed

    Whissell, Cynthia; Abramson, Charles I; Barber, Kelsey R

    2013-03-01

    This research examines the employment of cognitive or mentalist words in the titles of articles from three comparative psychology journals (Journal of Comparative Psychology, International Journal of Comparative Psychology, Journal of Experimental Psychology: Animal Behavior Processes; 8,572 titles, >100,000 words). The Dictionary of Affect in Language, coupled with a word search of titles, was employed to demonstrate cognitive creep. The use of cognitive terminology increased over time (1940-2010) and the increase was especially notable in comparison to the use of behavioral words, highlighting a progressively cognitivist approach to comparative research. Problems associated with the use of cognitive terminology in this domain include a lack of operationalization and a lack of portability. There were stylistic differences among journals including an increased use of words rated as pleasant and concrete across years for Journal of Comparative Psychology, and a greater use of emotionally unpleasant and concrete words in Journal of Experimental Psychology: Animal Behavior Processes.

  5. The potential of combining ion trap/MS/MS and TOF/MS for identification of emerging contaminants

    USGS Publications Warehouse

    Ferrer, I.; Furlong, E.T.; Heine, C.E.; Thurman, E.M.

    2002-01-01

    The use of a method combining ion trap tandem mass spectrometry (MS/MS) and time of flight mass spectrometry (TOF/MS) for identification of emerging contaminates was discussed. The two tools together complemented each other in sensitivity, fragmentation and accurate mass determination. Liquid chromatography/electrospray ionization/ion-trap tandem mass spectrometry (LC/ESI/MS/MS), in positive ion mode of operation, was used to separate and identify specific compounds. Diagnostic fragment ions were obtained for a polyethyleneglycol(PEG) homolog by ion trap MS/MS, and fragments were measured by TOF/MS. It was observed that the combined method gave an exact mass measurement that differed from the calculated mass.

  6. LC-MS-based metabolomics in drug metabolism.

    PubMed

    Chen, Chi; Gonzalez, Frank J; Idle, Jeffrey R

    2007-01-01

    Xenobiotic metabolism, a ubiquitous natural response to foreign compounds, elicits initiating signals for many pathophysiological events. Currently, most widely used techniques for identifying xenobiotic metabolites and metabolic pathways are empirical and largely based on in vitro incubation assays and in vivo radiotracing experiments. Recent work in our lab has shown that LC-MS-based metabolomic techniques are useful tools for xenobiotic metabolism research since multivariate data analysis in metabolomics can significantly rationalize the processes of xenobiotic metabolite identification and metabolic pathway analysis. In this review, the technological elements of LC-MS-based metabolomics for constructing high-quality datasets and conducting comprehensive data analysis are examined. Four novel approaches of using LC-MS-based metabolomic techniques in xenobiotic metabolism research are proposed and illustrated by case studies and proof-of-concept experiments, and the perspective on their application is further discussed.

  7. Selenium speciation analysis of Misgurnus anguillicaudatus selenoprotein by HPLC-ICP-MS and HPLC-ESI-MS/MS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Analytical methods for selenium (Se) speciation were developed using high performance liquid chromatography (HPLC) coupled to either inductively coupled plasma mass spectrometry (ICP-MS) or electrospray ionization tandem mass spectrometry (ESI-MS/MS). Separations of selenomethionine (Se-Met) and sel...

  8. Energy data base. Serial titles with ISSN listing

    SciTech Connect

    Hendricks, P.L.

    1984-03-01

    This issue of Serial Titles with ISSN Listing is the first revision of DOE/TIC-4579 to include the International Standard Serial Number (ISSN) for journals. The TIC journal authority was established to bring about conformity in citing the approximately 16,000 titles contained in this authority. It can prove to be a valuable tool in establishing the precise journal by ISSN and CODEN indication, especially for journals with the same title published in different locations. Serial Titles with ISSN Listing is comprised of two parts. Part 1 is an alphabetical listing by full title of the publication and also includes abbreviated title, CODEN, ISSN, coverage code, and country code. Part 2 is an ISSN-title correlation arranged in numeric order by ISSN and also includes the CODEN and full title.

  9. 29 CFR 452.7 - Bill of Rights, title I.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... enforcement of title I rights, as such, is limited to civil suit in a district court of the United States by... 29 Labor 2 2012-07-01 2012-07-01 false Bill of Rights, title I. 452.7 Section 452.7 Labor... DISCLOSURE ACT OF 1959 Other Provisions of the Act Affecting Title IV § 452.7 Bill of Rights, title......

  10. Streamlining the Title V application process

    SciTech Connect

    Fisher, P.; DeCesar, R.

    1997-02-01

    Companies in some US states face 1997 deadlines to apply for permits required by Title V of the 1990 Clean Air Act Amendments. Consultants assisting in the preparation of these applications for a variety of facilities have gleaned numerous cost-effective, time-saving approaches for performing the task. Some of the lessons that have been learned are given. Title V applications are often prepared by teams composed of members of a facility`s corporate environmental staff, plant environment staff, plant production staff and an outside consultant. Understanding the role of each team member and delineating lines of communication are keys to working efficiently. Because the focus is on demonstrating existing and future compliance, applicants should define at the outset which regulatory requirements apply to each emissions unit.

  11. Title IX: With New Opportunities, Girls' Interest Rises

    ERIC Educational Resources Information Center

    Toporek, Bryan

    2012-01-01

    On June 23, 1972, President Richard M. Nixon signed into law Title IX of the Education Amendments of 1972, which prohibits gender discrimination in any federally financed education program or activity. Title IX is far-reaching, but the law is most often associated with school and college athletics. Title IX allows schools to prove their athletic…

  12. 14 CFR 1245.109 - Assignment of title to NASA.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Assignment of title to NASA. 1245.109... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.109 Assignment of title to NASA. (a) The instrument of waiver set forth in § 1245.115(c) shall be voided by NASA with respect to the domestic title...

  13. 14 CFR 1245.109 - Assignment of title to NASA.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Assignment of title to NASA. 1245.109... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.109 Assignment of title to NASA. (a) The instrument of waiver set forth in § 1245.115(c) shall be voided by NASA with respect to the domestic title...

  14. 14 CFR 1245.109 - Assignment of title to NASA.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Assignment of title to NASA. 1245.109... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.109 Assignment of title to NASA. (a) The instrument of waiver set forth in § 1245.115(c) shall be voided by NASA with respect to the domestic title...

  15. 14 CFR 1245.109 - Assignment of title to NASA.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Assignment of title to NASA. 1245.109... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.109 Assignment of title to NASA. (a) The instrument of waiver set forth in § 1245.115(c) shall be voided by NASA with respect to the domestic title...

  16. 32 CFR 644.65 - Ordering title evidence.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Ordering title evidence. 644.65 Section 644.65... ESTATE HANDBOOK Acquisition Procurement of Title Evidence, Title Clearance, and Closings § 644.65... involved will be attached to the order or will be typed thereon. (b) Orders based on contiguous areas....

  17. 29 CFR 541.2 - Job titles insufficient.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Job titles insufficient. 541.2 Section 541.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND... General Regulations § 541.2 Job titles insufficient. A job title alone is insufficient to establish...

  18. 29 CFR 541.2 - Job titles insufficient.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Job titles insufficient. 541.2 Section 541.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND... General Regulations § 541.2 Job titles insufficient. A job title alone is insufficient to establish...

  19. 29 CFR 541.2 - Job titles insufficient.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Job titles insufficient. 541.2 Section 541.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND... General Regulations § 541.2 Job titles insufficient. A job title alone is insufficient to establish...

  20. 29 CFR 541.2 - Job titles insufficient.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Job titles insufficient. 541.2 Section 541.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND... General Regulations § 541.2 Job titles insufficient. A job title alone is insufficient to establish...

  1. 29 CFR 541.2 - Job titles insufficient.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Job titles insufficient. 541.2 Section 541.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND... General Regulations § 541.2 Job titles insufficient. A job title alone is insufficient to establish...

  2. Exploring New Directions: Title I in the Year 2000.

    ERIC Educational Resources Information Center

    Puma, Michael J.; Drury, Darrel W.

    This report takes stock of the present Title I program, identifies the most promising approaches to educating the nation's disadvantaged children, and offers guidance to policymakers seeking to improve Title I's effectiveness. The report draws upon hundreds of studies, evaluations, and other documents, and details the evolution of the Title I…

  3. 36 CFR 901.1 - Title and office.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Title and office. 901.1 Section 901.1 Parks, Forests, and Public Property PENNSYLVANIA AVENUE DEVELOPMENT CORPORATION BYLAWS OF THE CORPORATION § 901.1 Title and office. (a) Title. The name of the Corporation is the...

  4. 27 CFR 70.102 - Coordination with title 11.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Coordination with title 11... § 70.102 Coordination with title 11. (a) Certain failures to pay tax. No addition to the tax shall be... respect to a period during which a case is pending under Title 11 of the United States Code— (1) If...

  5. 24 CFR 206.35 - Title held by mortgagor.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title held by mortgagor. 206.35... HOME EQUITY CONVERSION MORTGAGE INSURANCE Eligibility; Endorsement Eligible Mortgagors § 206.35 Title held by mortgagor. The mortgagor shall hold title to the entire property which is the security for...

  6. 24 CFR 235.221 - Waived title objections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Waived title objections. 235.221... Involving Condominium Units § 235.221 Waived title objections. (a) General provisions. All of the provisions of § 203.389 of this chapter (relating to the waiver by the Secretary of objections to title)...

  7. 28 CFR 33.22 - Title to personal property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Title to personal property. 33.22 Section... Criminal Justice Block Grants Allocation of Funds § 33.22 Title to personal property. Section 808 of the Justice Assistance Act provides that notwithstanding any other provision of law, title to all...

  8. 48 CFR 3052.217-96 - Title (USCG).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of Provisions and Clauses 3052.217-96 Title (USCG). As prescribed in USCG guidance at (HSAR) 48 CFR 3017.9000(a) and (b), insert the following clause: Title (DEC 2003) (a) Unless otherwise provided... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Title (USCG)....

  9. 24 CFR 221.280 - Waived title objections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Waived title objections. 221.280... Cost Homes § 221.280 Waived title objections. (a) General provisions. All of the provisions of § 203.389 of this chapter (relating to the waiver by the Commissioner of objections to title) shall apply...

  10. 1 CFR 21.7 - Titles and subtitles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Titles and subtitles. 21.7 Section 21.7 General... DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General Code Structure § 21.7 Titles and subtitles. (a) The major divisions of the Code are titles, each of which brings together broadly...

  11. 38 CFR 36.4234 - Title and lien requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Title and lien... Site Preparation Financing Manufactured Home Units § 36.4234 Title and lien requirements. (a) The...) Legal title evidenced by such document as is customarily issued to the purchaser of a manufactured...

  12. 32 CFR 644.356 - Report on Government title.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Report on Government title. 644.356 Section 644... General Services Administration (gsa) § 644.356 Report on Government title. In all cases where Government... thereof), a report prepared by a qualified employee of the holding agency on the Government's title to...

  13. 23 CFR 200.7 - FHWA Title VI policy.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ensure compliance with Title VI of the Civil Rights Act of 1964; 49 CFR part 21; and related statutes and... 23 Highways 1 2010-04-01 2010-04-01 false FHWA Title VI policy. 200.7 Section 200.7 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND...

  14. 24 CFR 241.1080 - Eligibility of title.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Eligibility of title. 241.1080...-Eligibility Requirements § 241.1080 Eligibility of title. In order for the project to be eligible for insurance, the Commissioner shall determine that the title to the property is vested in the borrower as...

  15. 24 CFR 241.595 - Eligibility of title.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Eligibility of title. 241.595... Meters in Multifamily Projects Without a HUD-Insured or HUD-Held Mortgage Title § 241.595 Eligibility of title. In order for the property which is to be the security for a loan to be insured under this...

  16. 28 CFR 0.66 - Delegation respecting title opinions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Delegation respecting title opinions. 0... JUSTICE Environment and Natural Resources Division § 0.66 Delegation respecting title opinions. (a) The... General to opinions on the validity of titles to property acquired by or on behalf of the United...

  17. 40 CFR 300.220 - Related Title III issues.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PLAN Planning and Preparedness § 300.220 Related Title III issues. Other related Title III requirements are found in 40 CFR part 355. ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Related Title III issues....

  18. 48 CFR 35.014 - Government property and title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... title. 35.014 Section 35.014 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... title. (a) The requirements in part 45 for establishing and maintaining control over Government property... otherwise, the policies in subparagraphs (1) through (4) following, regarding title to equipment (and...

  19. 29 CFR 1978.108 - Captions, titles of cases.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Captions, titles of cases. 1978.108 Section 1978.108 Labor...) Rules of Procedure Litigation § 1978.108 Captions, titles of cases. (a) Cases described in § 1978.107(a...), Complainant v. (Name of named person), Respondent. (d) The titles listed in paragraphs (a), (b), and (c)...

  20. 44 CFR 208.27 - Title to equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... name, under 44 CFR 13.32(g), for example, when a Sponsoring Agency indicates or demonstrates that it... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Title to equipment. 208.27... Cooperative Agreements § 208.27 Title to equipment. Title to equipment purchased by a Sponsoring Agency...

  1. 13 CFR 314.9 - Recorded statement-title.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Recorded statement-title. 314.9... PROPERTY Personal Property § 314.9 Recorded statement—title. For all Projects which EDA determines involve... by EDA to be recorded, the Recipient must hold title to the Personal Property acquired or improved...

  2. 44 CFR 208.46 - Title to equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CFR 13.32(g), when a Sponsoring Agency indicates or demonstrates that it cannot fulfill its... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Title to equipment. 208.46... Agreements § 208.46 Title to equipment. Title to equipment purchased by a Sponsoring Agency with...

  3. 32 CFR 644.356 - Report on Government title.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Report on Government title. 644.356 Section 644... General Services Administration (gsa) § 644.356 Report on Government title. In all cases where Government... thereof), a report prepared by a qualified employee of the holding agency on the Government's title to...

  4. 32 CFR 644.356 - Report on Government title.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Report on Government title. 644.356 Section 644... General Services Administration (gsa) § 644.356 Report on Government title. In all cases where Government... thereof), a report prepared by a qualified employee of the holding agency on the Government's title to...

  5. 32 CFR 644.356 - Report on Government title.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Report on Government title. 644.356 Section 644... General Services Administration (gsa) § 644.356 Report on Government title. In all cases where Government... thereof), a report prepared by a qualified employee of the holding agency on the Government's title to...

  6. 32 CFR 644.356 - Report on Government title.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Report on Government title. 644.356 Section 644... General Services Administration (gsa) § 644.356 Report on Government title. In all cases where Government... thereof), a report prepared by a qualified employee of the holding agency on the Government's title to...

  7. 48 CFR 32.503-14 - Protection of Government title.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Protection of Government... of Government title. (a) Since the Progress Payments clause gives the Government title to all of the... ensure that the Government title to these inventories is not compromised by other...

  8. 32 CFR 644.71 - Final title assembly.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Final title assembly. 644.71 Section 644.71 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Acquisition Procurement of Title Evidence, Title Clearance, and Closings § 644.71...

  9. 32 CFR 644.66 - Payment for title services.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Payment for title services. 644.66 Section 644.66 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Acquisition Procurement of Title Evidence, Title Clearance, and...

  10. 29 CFR 4022.63 - Estimated title IV benefit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Estimated title IV benefit. 4022.63 Section 4022.63 Labor... PAYABLE IN TERMINATED SINGLE-EMPLOYER PLANS Benefit Reductions in Terminating Plans § 4022.63 Estimated... administrator shall determine each participant's estimated title IV benefit. The estimated title IV...

  11. Fostering Parental Engagement in a Rural Title I Elementary School

    ERIC Educational Resources Information Center

    McDowell, Joyce R.

    2014-01-01

    The major purpose of this study was to find out how to encourage Title I family engagement as the school funds were decreasing in the next school year. I wanted to determine how to continue, as well as increase, parental engagement at a Title I elementary school in a rural setting. The Title I program focuses on assisting students who are…

  12. 23 CFR 200.7 - FHWA Title VI policy.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... ensure compliance with Title VI of the Civil Rights Act of 1964; 49 CFR part 21; and related statutes and... 23 Highways 1 2012-04-01 2012-04-01 false FHWA Title VI policy. 200.7 Section 200.7 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND...

  13. 23 CFR 200.7 - FHWA Title VI policy.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... ensure compliance with Title VI of the Civil Rights Act of 1964; 49 CFR part 21; and related statutes and... 23 Highways 1 2014-04-01 2014-04-01 false FHWA Title VI policy. 200.7 Section 200.7 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND...

  14. 23 CFR 200.7 - FHWA Title VI policy.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... ensure compliance with Title VI of the Civil Rights Act of 1964; 49 CFR part 21; and related statutes and... 23 Highways 1 2013-04-01 2013-04-01 false FHWA Title VI policy. 200.7 Section 200.7 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND...

  15. MS Power Point vs Prezi in Higher Education

    ERIC Educational Resources Information Center

    Kiss, Gabor

    2016-01-01

    The teachers use different presentation tools in Higher Education to make the presentation enjoyable for the students. I used MS Power Point or Prezi in my presentations in two different groups of the freshmen students at the University. The aim of this research was an analysis of the paper results in two groups of students to reveal the influence…

  16. Gearing up for Title 5 operating permits

    SciTech Connect

    Klaber, K.; Weiss, K. )

    1994-06-01

    Title 5 of the 1990 Clean Air Act Amendments (CAAA) establishes a massive new operating permit program, which will be administered by state agencies in accordance with federal guidelines. Formal requirements regarding operating-permits were promulgated by the US Environmental Protection Agency (EPA) on July 21, 1992 (40 CFR 70). The Title 5 program will require many chemical manufacturing facilities to apply for and obtain operating permits that address air emissions from the entire facility. A major impact of the Title 5 program is that facilities will now be required to implement measures to routinely demonstrate that they are operating in compliance with the terms of the permit. Otherwise, facilities will be considered out of compliance. Once the new permits are in place, the burden will be on the facility to prove routine compliance to prevent any enforcement action. According to EPA, the new permits are not intended to impose any new regulatory requirements on a facility. Rather, they will serve as an enforcement tool.

  17. Decision Making in Intercollegiate Athletics: One Institution's Journey to Maintain Title IX Compliance

    ERIC Educational Resources Information Center

    Rowland, John W.

    2012-01-01

    The allocation of resources and participation opportunities in intercollegiate athletics has been a debate among researchers for nearly 40 years. Title IX and traditionally male-dominated budgeting practices continue to be opposing forces that shape the financial and gender makeup of university athletic departments. In fact, the need to be Title…

  18. The Perpetuation of Risk: Organizational and Institutional Policies and Practices in a Title 1 School

    ERIC Educational Resources Information Center

    McMahon, Brenda

    2011-01-01

    This empirical mixed methods study examines educators' understandings of student risk factors. The research was conducted in a Title 1 combination middle high school in the Florida panhandle that had been open for three years and had received a grade of F school in each of these years. In Florida, schools are graded according to the Florida…

  19. The Influence of Neutral Gender Words on Translating Job Titles from English Language into Arabic Language

    ERIC Educational Resources Information Center

    Mubaideen, Taghreed

    2015-01-01

    This paper aims at investigating the influence of neutral gender words on translating job titles from English language into Arabic Language. This qualitative research includes 20 postgraduate students doing their M.A in Applied Linguistics at the Department of English Language and Literature at Mu'tah University for the academic year 2015/2016.…

  20. An Evaluation of the Omaha Westside Public Schools Title I Mathematics Programs.

    ERIC Educational Resources Information Center

    Thompson, Pat; Novak, Carl D.

    The Omaha Westside Public Schools Director of Research made a thorough investigation of student participation in the commercially available mathematics programs, the Hoffman Mathematics System and Systems 80, and parental attitudes about student participation. This report answers questions dealing with the justification of Title I funds resulting…

  1. Titles in highly ranked multidisciplinary psychology journals 1966-2011: more words and punctuation marks allow for the communication of more information.

    PubMed

    Whissell, Cynthia

    2013-12-01

    Titles of articles in seven highly ranked multidisciplinary psychology journals for every fifth year between 1966 and 2011 (inclusive) were studied in terms of title length, word length, punctuation density, and word pleasantness, activation, and concreteness (assessed by the Dictionary of Affect in Language). Titles grew longer (by three words) and were more frequently punctuated (by one colon or comma for every other article) between 1966 and 2011. This may reflect the increasing complexity of psychology and satisfy readers' requirements for more specific information. There were significant differences among journals (e.g., titles in the Annual Review of Psychology were scored by the Dictionary of Affect as the most pleasant, and those in Psychological Bulletin as the least pleasant) and among categories of journals (e.g., titles in review journals employed longer words than those in research or association journals). Differences were stable across time and were employed to successfully categorize titles from a validation sample.

  2. Treatment optimization in MS: Canadian MS Working Group updated recommendations.

    PubMed

    Freedman, Mark S; Selchen, Daniel; Arnold, Douglas L; Prat, Alexandre; Banwell, Brenda; Yeung, Michael; Morgenthau, David; Lapierre, Yves

    2013-05-01

    The Canadian Multiple Sclerosis Working Group (CMSWG) developed practical recommendations in 2004 to assist clinicians in optimizing the use of disease-modifying therapies (DMT) in patients with relapsing multiple sclerosis. The CMSWG convened to review how disease activity is assessed, propose a more current approach for assessing suboptimal response, and to suggest a scheme for switching or escalating treatment. Practical criteria for relapses, Expanded Disability Status Scale (EDSS) progression and MRI were developed to classify the clinical level of concern as Low, Medium and High. The group concluded that a change in treatment may be considered in any RRMS patient if there is a high level of concern in any one domain (relapses, progression or MRI), a medium level of concern in any two domains, or a low level of concern in all three domains. These recommendations for assessing treatment response should assist clinicians in making more rational choices in their management of relapsing MS patients. PMID:23603165

  3. Academic Achievement Differences between Title I Students Enrolled in Music Classes and Title I Students Who Are Not

    ERIC Educational Resources Information Center

    McDaniel, Brian

    2011-01-01

    Purpose. The purpose of the study was to determine academic achievement differences between those Title I students enrolled in music classes and Title I students who are not enrolled in music classes. A second purpose was to determine educators' perceptions regarding the educational justice implications of excluding nonproficient Title I students…

  4. Challenges in implementing efficient Title IV and Title V permit programs

    SciTech Connect

    Sprott, R.

    1997-12-31

    Integrating title IV acid rain and title V operating permits in an efficient manner poses numerous challenges. Federal rules and policy memos about these programs often conflict or lead to actions that are difficult to implement at best. Both permitting programs are complex and controversial, but the title IV permitting rules are particularly difficult to use and understand. Clear lines of jurisdiction for various aspects of the acid rain program are lacking in some cases, and regulators have been slow to recognize and solve these problems. There are numerous issues that have arisen during the initial stages of developing permits for title IV affected sources. Some have or are being resolved; others remain as potential impediments to efficient permitting. Utah and other western states have been working with the utility industry and US Environmental Protection Agency (EPA) to resolve these and other issues and some problems have been resolved. However, some state and industry officials feel that EPA should take the lead to conduct a series title IV implementation workshops in partnership with states and the utilities. This paper describes solutions to some common implementation problems and identifies challenges that remain to be solved.

  5. Isotopic analyses by ICP-MS in clinical samples.

    PubMed

    Rodushkin, Ilia; Engström, Emma; Baxter, Douglas C

    2013-03-01

    This critical review focuses on inductively coupled plasma mass spectrometry (ICP-MS) based applications for isotope abundance ratio measurements in various clinical samples relevant to monitoring occupational or environmental exposure, human provenancing and reconstruction of migration pathways as well as metabolic research. It starts with a brief overview of recent advances in ICP-MS instrumentation, followed by selected examples that cover the fields of accurate analyte quantification using isotope dilution, tracer studies in nutrition and toxicology, and areas relying upon natural or man-made variations in isotope abundance ratios (Pb, Sr, actinides and stable heavy elements). Finally, some suggestions on future developments in the field are provided.

  6. Futurist Art: Motion and Aesthetics As a Function of Title

    PubMed Central

    Mastandrea, Stefano; Umiltà, Maria A.

    2016-01-01

    Very often the titles of Futurist paintings contain words denoting movement in order to satisfy their artistic poetic focused on motion and velocity. The aim of the present study is to investigate the reported dynamism and aesthetic quality of several Futurist artworks as a function of their title. Ten Futurist artworks with a movement-related word in the title were selected for this study. The titles were manipulated, resulting in four conditions for each painting: the “original title” with the movement word; an “increased” title in which an adjective was added in order to intensify the sense of dynamism; a “decreased” title, in which the movement word was eliminated; no title. Participants evaluated the movement suggested by each painting in the four different title conditions, rated their beauty and reported how much they liked the work. Results showed that the manipulation of the title had an effect on the reported movement: compared to the others, paintings presented with the “original” and with the “increased” title received significant higher movement scores. Of interest, beauty did not differ across conditions, but liking was higher for the conditions with more movement. Lastly, positive correlations between the quantity of perceived movement and aesthetic evaluation were found. From the present results it can be concluded that Futurists attributed much relevance to the titles of their artworks in order to effectively increase the expression of the movement represented. PMID:27242471

  7. Research '70.

    ERIC Educational Resources Information Center

    Toronto Board of Education (Ontario). Research Dept.

    Thirteen research reports on a wide variety of issues are annotated in this bibliography that is intended for interested school personnel. Descriptions of studies ranging from the diagnostic value of children's drawings to the effects of bilingualism are brief. Titles reflecting the content of the studies are: The Measurement of Socio-Economic…

  8. Fast and accurate database searches with MS-GF+Percolator

    SciTech Connect

    Granholm, Viktor; Kim, Sangtae; Navarro, Jose' C.; Sjolund, Erik; Smith, Richard D.; Kall, Lukas

    2014-02-28

    To identify peptides and proteins from the large number of fragmentation spectra in mass spectrometrybased proteomics, researches commonly employ so called database search engines. Additionally, postprocessors like Percolator have been used on the results from such search engines, to assess confidence, infer peptides and generally increase the number of identifications. A recent search engine, MS-GF+, has previously been showed to out-perform these classical search engines in terms of the number of identified spectra. However, MS-GF+ generates only limited statistical estimates of the results, hence hampering the biological interpretation. Here, we enabled Percolator-processing for MS-GF+ output, and observed an increased number of identified peptides for a wide variety of datasets. In addition, Percolator directly reports false discovery rate estimates, such as q values and posterior error probabilities, as well as p values, for peptide-spectrum matches, peptides and proteins, functions useful for the whole proteomics community.

  9. [Applications of MALDI-TOF-MS in clinical microbiology laboratory].

    PubMed

    Carbonnelle, Etienne; Nassif, Xavier

    2011-10-01

    For twenty years, mass spectrometry (MS) has emerged as a particularly powerful tool for analysis and characterization of proteins in research. It is only recently that this technology, especially MALDI-TOF-MS (Matrix Assisted Laser Desorption Ionization Time-Of-Flight) has entered the field of routine microbiology. This method has proven to be reliable and safe for the identification of bacteria, yeasts, filamentous fungi and dermatophytes. MALDI-TOF-MS is a rapid, precise and cost-effective method for identification, compared to conventional phenotypic techniques or molecular biology. Its ability to analyse whole microorganisms with few sample preparation has greatly reduced the time to identification (1-2 min). Furthermore, this technology can be used to identify bacteria directly from clinical samples as blood culture bottles or urines. Future applications will be developed in order to provide direct information concerning virulence or resistance protein markers.

  10. Catalytic oxidizers and Title V requirements

    SciTech Connect

    Uberoi, M.; Rach, S.E.

    1999-07-01

    Catalytic oxidizers have been used to reduce VOC emissions from various industries including printing, chemical, paint, coatings, etc. A catalytic oxidizer uses a catalyst to reduce the operating temperature for combustion to approximately 600 F, which is substantially lower than thermal oxidation unit. Title V requirements have renewed the debate on the best methods to assure compliance of catalytic oxidizers, with some suggesting the need for continuous emission monitoring equipment. This paper will discuss the various aspects of catalytic oxidation and consider options such as monitoring inlet/outlet temperatures, delta T across the catalyst, periodic laboratory testing of catalyst samples, and preventive maintenance procedures as means of assuring continuous compliance.

  11. Title list of documents made publicly available

    SciTech Connect

    Not Available

    1983-07-01

    The Title List of Documents Made Publicly Available is a monthly publication. It contains descriptions of the information received and generated by the US Nuclear Regulatory Commission (NRC). This information includes (1) docketed material associated with civilian nuclear power plants and other uses of radioactive materials and (2) nondocketed material received and generated by NRC pertinent to its role as a regulatory agency. As used here, docketed does not refer to Court dockets; it refers to the system by which NRC maintains its regulatory records. This series of documents is indexed by a Personal Author Index, a Corporate Source Index, and a Report Number Index.

  12. Title list of documents made publicly available

    SciTech Connect

    Not Available

    1983-02-01

    The Title List of Documents Made Publicly Available is a monthly publication. It contains descriptions of the information received and generated by the US Nuclear Regulatory Commission (NRC). This information includes (1) docketed material associated with civilian nuclear power plants and other uses of radioactive materials and (2) nondocketed material received and generated by NRC pertinent to its role as a regulatory agency. As used here, docketed does not refer to Court dockets; it refers to the system by which NRC maintains its regulatory records. This series of documents is indexed by a Personal Author Index, a Corporate Source Index, and a Report Number Index.

  13. Ryan White CARE Act Title IV programs: a preliminary characterization of benefits and costs.

    PubMed

    Abramowitz, Susan; Greene, Danielle

    2005-01-01

    Congress enacted the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act in 1990 to address the unmet health needs of persons living with HIV (PLWH) by funding primary healthcare and support services to enhance access to and retention in care. The CARE Act was amended and reauthorized in 1996 and in 2000, and again in December 2006. As originally enacted, the CARE Act was a compromise across a wide political divide. A structure was established that distributed Ryan White CARE Act (RWCA) funds through five federal titles, with different parameters set for each title. Some funds were placed under federal control, while others were controlled locally and distributed to cities and states. Some funds were earmarked for specific services or populations, such as medications; others could be assigned according to a community's priorities. Title IV, the section of the RWCA dedicated to serving women, children, youth, and families who are infected with and affected by HIV/AIDS, is unique, even given the diversity of the other titles. The Title IV program was first implemented in 1988 as the Pediatric AIDS Demonstration Program. It became part of the CARE Act in 1994, and its purpose was expanded at that time to create better links between medical and support services. Although it is the smallest of the titles, with less than 4 percent of the RWCA budget, it may have the broadest mission: providing medical, logistical, psychosocial, and developmental care not just to persons living with the virus, but to entire families. In addition to its focus on this target population, Title IV is unique in its recognition of the need for, and historic support of, comprehensive systems of care to improve, expand, and coordinate service delivery, HIV-prevention efforts, and clinical research. Title IV was excluded from a 10 percent administrative cap on administrative expenses, which enables its funded programs to accomplish this mission. As of 2003, Title IV supported 74 family

  14. Immunomodulatory treatments and cognition in MS.

    PubMed

    Mückschel, M; Beste, C; Ziemssen, T

    2016-09-01

    Cognitive impairments occur frequently and early in multiple sclerosis (MS) and contribute significantly to a reduced quality of life of patients with MS. Executive functions (EFs) play a pivotal role for the behavioral adaption to the environment and are also crucial for compensatory processes of cognitive impairments. Disease-modifying drugs (DMDs) are effective in reducing the frequency of relapses and slow the disease progression in MS. The effects of DMDs on cognitive impairments were reviewed with a special focus on EFs. Most studies show some beneficial effects of DMDs on cognition in MS, but the evidence for effects on EFs is sparse. Additionally, most studies suffer from methodological issues, small sample sizes and learning effects. We discuss that EFs may constitute a viable cognitive endpoint for cognitive impairments in MS, which could foster the early detection of subtle cognitive changes in MS. PMID:27580907

  15. The impact of course title and instructor gender on student perceptions and interest in a women's and gender studies course.

    PubMed

    Spoor, Jennifer R; Lehmiller, Justin J

    2014-01-01

    Diversity awareness has enormous benefits, and universities in the United States increasingly require students to complete diversity-related courses. Prior research has demonstrated that students' initial attitudes toward these courses affect their subsequent engagement, as well as the quality of their learning experience; however, very little research has examined how these initial attitudes are formed. We conducted an experiment to examine this issue in the context of a women's and gender studies course in psychology. Participants read one of two identical course descriptions that varied only the course title (i.e., Psychology of Gender versus Psychology of Women) and instructor gender. Participants perceived a women-titled course to be narrowly focused compared to an identical gender-titled course and were more interested in taking the gender-titled course. Instructor gender had no effects on any of the variables. Additionally, female participants had more positive attitudes toward the course than male participants, regardless of title. Exploratory mediation analyses indicated that the main effects of course title and participant gender were mediated by perceptions of course content. Implications for improving student experiences and interest in diversity-related courses are discussed. PMID:25268353

  16. The Impact of Course Title and Instructor Gender on Student Perceptions and Interest in a Women's and Gender Studies Course

    PubMed Central

    Spoor, Jennifer R.; Lehmiller, Justin J.

    2014-01-01

    Diversity awareness has enormous benefits, and universities in the United States increasingly require students to complete diversity-related courses. Prior research has demonstrated that students' initial attitudes toward these courses affect their subsequent engagement, as well as the quality of their learning experience; however, very little research has examined how these initial attitudes are formed. We conducted an experiment to examine this issue in the context of a women's and gender studies course in psychology. Participants read one of two identical course descriptions that varied only the course title (i.e., Psychology of Gender versus Psychology of Women) and instructor gender. Participants perceived a women-titled course to be narrowly focused compared to an identical gender-titled course and were more interested in taking the gender-titled course. Instructor gender had no effects on any of the variables. Additionally, female participants had more positive attitudes toward the course than male participants, regardless of title. Exploratory mediation analyses indicated that the main effects of course title and participant gender were mediated by perceptions of course content. Implications for improving student experiences and interest in diversity-related courses are discussed. PMID:25268353

  17. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTH AND... obligation, 86.4(b) Form, 86.4(c) Athletics, ; 86.41 Adjustment period, ; 86.41(d) Contact sport defined, 86... responsible employee”, 86.8(a) (b) H Health and Insurance Benefits and Services, ; 86.39, 86.56...

  18. Title XX and CETA. A Coordination Guide for Title XX Administrators.

    ERIC Educational Resources Information Center

    Urban Management Consultants of San Francisco, Inc., CA.

    Written for the social service (Title XX) administrator at the State or sub-State level, this guide is intended to serve four major purposes: (1) Provide selected insights into what the Comprehensive Employment and Training Act (CETA) is and how it works; (2) point out potential areas for coordination which, from study or field experience, hold…

  19. Has operating permitting really changed with Title V? Reflecting on the Title V operating permit program

    SciTech Connect

    Goldstein, D.R.; Cressman, A.W.

    1999-07-01

    Now that some state regulatory agencies are reviewing Title V permit applications and issuing permits, evaluation of the process can be made in comparison with the original goals of the Title V permitting program. In addition, assessment of the terms and conditions that are being incorporated into permits, the nature of draft permits that are issued to facilities for comment, and the extent and type of negotiation that have been conducted with agencies to develop successful Title V permits, will be helpful for facilities that are currently undergoing application review. In working with a Fortune 500 surface coating company, fourteen Title V permit applications were developed and submitted for plants located in Maryland, Pennsylvania, Ohio, New Jersey, Illinois, Georgia, West Virginia, Wisconsin, Indiana and southern California. Draft permits have been issued for several of the plants, and differences in the terms and conditions, testing requirements, and permit format and structure have been noted between states. One of the issued permits required modification, and the process was one of the first for this state agency.

  20. Measurement of oxidative stress parameters using liquid chromatography-tandem mass spectroscopy (LC-MS/MS)

    SciTech Connect

    Winnik, Witold M. Kitchin, Kirk T.

    2008-11-15

    There is increasingly intense scientific and clinical interest in oxidative stress and the many parameters used to quantify the degree of oxidative stress. However, there remain many analytical limitations to currently available assays for oxidative stress markers. Recent improvements in software, hardware, and instrumentation design have made liquid chromatography and tandem mass spectroscopy (LC-MS/MS) methods optimal choices for the determination of many oxidative stress markers. In particular, LC-MS/MS often provides the advantages of higher specificity, higher sensitivity, and the capacity to determine multiple analytes (e.g. 4-11 oxidative stress markers per LC run) when compared to other available methods, such as gas chromatography-MS, immunoassays, spectrophotometric or flourometric assays. LC-MS/MS methods are also compatible with cleanup and sample preparation methods including prior solid phase extraction or automated two dimensional LC/LC chromatography followed by MS/MS. LC-MS/MS provides three analytical filtering functions: (1) the LC column provides initial separation as each analyte elutes from the column. (2) The first MS dimension isolates ions of a particular mass-to-charge (m/z) ratio. (3) The selected precursor ion is fragmented into product ions that provide structural information about the precursor ion. Quantitation is achieved based on the abundances of the product ions. The sensitivity limits for LC-MS/MS usually lie within the range of fg-pg of analyte per LC on-column injection. In this article, the present capabilities of LC-MS/MS are briefly presented and some specific examples of the strengths of these LC-MS/MS assays are discussed. The selected examples include methods for isoprostanes, oxidized proteins and amino acids, and DNA biomarkers of oxidative stress.

  1. LC-MS/MS in the Clinical Laboratory – Where to From Here?

    PubMed Central

    Grebe, Stefan KG; Singh, Ravinder J

    2011-01-01

    Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has seen enormous growth in clinical laboratories during the last 10–15 years. It offers analytical specificity superior to that of immunoassays or conventional high performance/pressure liquid chromatography (HPLC) for low molecular weight analytes and has higher throughput than gas chromatography-mass spectrometry (GC-MS). Drug/Toxicology and Biochemical Genetics/Newborn Screening laboratories were at the vanguard of clinical LC-MS/MS use, but have been eclipsed by Endocrine laboratories. In USA reference/referral laboratories, most steroids and biogenic amines are now assayed by LC-MS/MS, and the technology has started to penetrate into smaller laboratories. Assays for mineralo- and gluco-corticoids and their precursors, sex steroids, metanephrines and 25-hydroxy vitamin D highlight the advantages of LC-MS/MS. However, several limitations of LC-MS/MS have become apparent, centring on the interacting triangle of sensitivity – specificity – throughput. While sample throughput is higher than for conventional HPLC or GC-MS, it lags behind automated immunoassays. Techniques which improve throughput include direct sample injection, LC-multiplexing and samplemultiplexing. Measures to improve specificity and sensitivity include sample clean-up and optimising chromatography to avoid interferences and ion suppression due to sample-matrix components. Next generation instrumentation may offer additional benefits. The next challenge for clinical LC-MS/MS is peptide/protein analysis. The quest for multi-biomarker profiles for various diseases has largely failed, but targeted peptide and protein testing by LC-MS/MS, directed at analytical and clinical questions that need to be answered, is proving highly successful. We anticipate that this will result in similar growth of clinical protein/peptide LC-MS/MS as has been seen for low molecular weight applications. PMID:21451775

  2. Measurement of oxidative stress parameters using liquid chromatography-tandem mass spectroscopy (LC-MS/MS).

    PubMed

    Winnik, Witold M; Kitchin, Kirk T

    2008-11-15

    There is increasingly intense scientific and clinical interest in oxidative stress and the many parameters used to quantify the degree of oxidative stress. However, there remain many analytical limitations to currently available assays for oxidative stress markers. Recent improvements in software, hardware, and instrumentation design have made liquid chromatography and tandem mass spectroscopy (LC-MS/MS) methods optimal choices for the determination of many oxidative stress markers. In particular, LC-MS/MS often provides the advantages of higher specificity, higher sensitivity, and the capacity to determine multiple analytes (e.g. 4-11 oxidative stress markers per LC run) when compared to other available methods, such as gas chromatography-MS, immunoassays, spectrophotometric or fluorometric assays. LC-MS/MS methods are also compatible with cleanup and sample preparation methods including prior solid phase extraction or automated two dimensional LC/LC chromatography followed by MS/MS. LC-MS/MS provides three analytical filtering functions: (1) the LC column provides initial separation as each analyte elutes from the column. (2) The first MS dimension isolates ions of a particular mass-to-charge (m/z) ratio. (3) The selected precursor ion is fragmented into product ions that provide structural information about the precursor ion. Quantitation is achieved based on the abundances of the product ions. The sensitivity limits for LC-MS/MS usually lie within the range of fg-pg of analyte per LC on-column injection. In this article, the present capabilities of LC-MS/MS are briefly presented and some specific examples of the strengths of these LC-MS/MS assays are discussed. The selected examples include methods for isoprostanes, oxidized proteins and amino acids, and DNA biomarkers of oxidative stress. PMID:18547599

  3. Gadofosveset: MS 325, MS 32520, Vasovist, ZK 236018.

    PubMed

    2004-01-01

    Gadofosveset [MS 325, MS 32520, Vasovist, ZK 236018], a gadolinium-based chelate, is an injectable angiography imaging agent for use in magnetic resonance imaging (MRI) scans. The agent is being developed by EPIX Medical (formerly Metasyn) for diagnostic imaging of blood vessels of the cardiovascular system. Gadofosveset has potential as an alternative to the range of x-ray, invasive, catheter-based angiograms and thallium stress tests currently used in the diagnosis of coronary artery disease. The agent may also have applications in the diagnosis of peripheral vascular disease, thrombosis and breast cancer. Unlike conventional MRI contrast agents, gadofosveset binds to serum albumin in the blood and moves with the blood through the arteries and veins for an extended period of time before being excreted by the kidneys. The MRI with gadofosveset allows 3D images of the whole body to be accessed in one imaging session. Moreover, it makes it possible to view vessel structures.EPIX Medical has acquired an exclusive licence from the Massachusetts General Hospital to a certain technology, including patents and patent applications, that relates to the company's product candidates such as gadofosveset.EPIX Medical, Mallinckrodt (Tyco International) and Schering AG signed several agreements to develop, manufacture and market gadofosveset (formerly known as Mallinckrodt's AngioMARK). Initially, in June 2000 Schering AG acquired worldwide exclusive rights (except for Japan) from EPIX Medical to develop and market gadofosveset. Under the terms of the agreement, EPIX Medical is responsible for the completion of clinical trials and filing for approval in the US, while Schering AG undertakes responsibility for clinical investigation of gadofosveset outside the US. Mallinckrodt is responsible and will undertake a long-term supply contract for gadofosveset for clinical development and sales. Schering's subsidiary Berlex will market the product in the US after the approval via its

  4. Approaches to Climate Change & Health in Cuba: Guillermo Mesa MD MPhil, Director, Disasters & Health, National School of Public Health. Paulo Ortiz MS PhD, Senior Researcher, Climate Center, Cuban Meteorology Institute.

    PubMed

    Mesa, Guillermo; Ortiz, Paulo; Gorry, Conner

    2015-04-01

    The US National Institutes of Health predict climate change will cause an additional 250,000 deaths between 2030 and 2050, with damages to health costing US$2-$4 billion by 2030. Although much debate still surrounds climate change, island ecosystems-such as Cuba's-in the developing world are arguably among the most vulnerable contexts in which to confront climate variability. Beginning in the 1990s, Cuba launched research to develop the evidence base, set policy priorities, and design mitigation and adaptation actions specifically to address climate change and its effects on health. Two researchers at the forefront of this interdisciplinary, intersectoral effort are epidemiologist Dr Guillermo Mesa, who directed design and implementation of the nationwide strategy for disaster risk reduction in the Cuban public health system as founding director of the Latin American Center for Disaster Medicine (CLAMED) and now heads the Disasters and Health department at the National School of Public Health; and Dr Paulo Ortiz, a biostatistician and economist at the Cuban Meteorology Institute's Climate Center (CENCLIM), who leads the research on Cuba's Climate and Health project and is advisor on climate change and health for the UN Economic Commission for Latin America and the Caribbean (ECLAC).

  5. Approaches to Climate Change & Health in Cuba: Guillermo Mesa MD MPhil, Director, Disasters & Health, National School of Public Health. Paulo Ortiz MS PhD, Senior Researcher, Climate Center, Cuban Meteorology Institute.

    PubMed

    Mesa, Guillermo; Ortiz, Paulo; Gorry, Conner

    2015-04-01

    The US National Institutes of Health predict climate change will cause an additional 250,000 deaths between 2030 and 2050, with damages to health costing US$2-$4 billion by 2030. Although much debate still surrounds climate change, island ecosystems-such as Cuba's-in the developing world are arguably among the most vulnerable contexts in which to confront climate variability. Beginning in the 1990s, Cuba launched research to develop the evidence base, set policy priorities, and design mitigation and adaptation actions specifically to address climate change and its effects on health. Two researchers at the forefront of this interdisciplinary, intersectoral effort are epidemiologist Dr Guillermo Mesa, who directed design and implementation of the nationwide strategy for disaster risk reduction in the Cuban public health system as founding director of the Latin American Center for Disaster Medicine (CLAMED) and now heads the Disasters and Health department at the National School of Public Health; and Dr Paulo Ortiz, a biostatistician and economist at the Cuban Meteorology Institute's Climate Center (CENCLIM), who leads the research on Cuba's Climate and Health project and is advisor on climate change and health for the UN Economic Commission for Latin America and the Caribbean (ECLAC). PMID:26027580

  6. The Design and Implementation of a Model Evaluation Capability. 1975-76 Final Report. Title III Project.

    ERIC Educational Resources Information Center

    Austin Independent School District, TX. Office of Research and Evaluation.

    The Austin Independent School District received an Elementary and Secondary Education Act Title III grant in 1973 to develop an internal research and evaluation capability. Funding was provided the resulting Office of Research and Evaluation (ORE) for three years. The foci of the original grant were (1) to develop a district evaluation model, (2)…

  7. 34 CFR 85.1017 - Title IV, HEA program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (NONPROCUREMENT) Definitions § 85.1017 Title IV, HEA program. A title IV, HEA program includes any program listed in 34 CFR 668.1(c). Authority: E.O. 12549 (3 CFR, 1986 Comp., p.1890: E.O. 12689 (3 CFR, 1989 Comp... 34 Education 1 2010-07-01 2010-07-01 false Title IV, HEA program. 85.1017 Section...

  8. 22 CFR 92.25 - Title of affidavit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Title of affidavit. 92.25 Section 92.25 Foreign... Acts § 92.25 Title of affidavit. Generally an affidavit taken for use in a pending cause must be... is taken or if the affidavit is not to be used in any cause in court, no title need be given....

  9. 34 CFR 85.1018 - Title IV, HEA transaction.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (3 CFR, 1986 Comp., p. 189) E.O. 12689 (3 CFR, 1989 Comp., p. 235); 20 U.S.C. 1082, 1094, 1221e-3 and... 34 Education 1 2010-07-01 2010-07-01 false Title IV, HEA transaction. 85.1018 Section 85.1018... (NONPROCUREMENT) Definitions § 85.1018 Title IV, HEA transaction. A title IV, HEA transaction includes: (a)...

  10. Beyond the proteome: Mass Spectrometry Special Interest Group (MS-SIG) at ISMB/ECCB 2013

    SciTech Connect

    Ryu, Soyoung; Payne, Samuel H.; Schaab, Christoph; Xiao, Wenzhong

    2014-07-02

    Mass spectrometry special interest group (MS-SIG) aims to bring together experts from the global research community to discuss highlights and challenges in the field of mass spectrometry (MS)-based proteomics and computational biology. The rapid echnological developments in MS-based proteomics have enabled the generation of a large amount of meaningful information on hundreds to thousands of proteins simultaneously from a biological sample; however, the complexity of the MS data require sophisticated computational algorithms and software for data analysis and interpretation. This year’s MS-SIG meeting theme was ‘Beyond the Proteome’ with major focuses on improving protein identification/quantification and using proteomics data to solve interesting problems in systems biology and clinical research.

  11. Sulphite Railroad Bridge1896, Title Sheet Sulphite Railroad Bridge, Former ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Sulphite Railroad Bridge-1896, Title Sheet - Sulphite Railroad Bridge, Former Boston & Maine Railroad (originally Tilton & Franklin Railroad) spanning Winnipesautee River, Franklin, Merrimack County, NH

  12. Title Sheet, National Home for Disabled Volunteer Soldiers, Northwestern Branch ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Title Sheet, National Home for Disabled Volunteer Soldiers, Northwestern Branch - National Home for Disabled Volunteer Soldiers, Northwestern Branch, 5000 West National Avenue, Milwaukee, Milwaukee County, WI

  13. 40 CFR 35.6330 - Title to federally owned property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Personal Property Requirements Under A Cooperative Agreement § 35.6330 Title to...

  14. Experience in automating the Title V permit application

    SciTech Connect

    Ashcraft, T.; O`Brien, J.

    1995-12-31

    Title V of the Clean Air Act Amendments of 1990 requires that the owners and operators of certain types of industrial plants obtain a federal operating permit. In general, any plant that meets the definition of a major source must either obtain a Title V Operating permit, or take actions to ``act out`` of the Title V program. This Technical Paper describes the experience of the authors in designing and implementing a computer system for data management and reporting of Clean Air Act Title V Permit information. Recommendations are also provided to guide companies and industry groups who are planning to undertake similar automation projects.

  15. Cumulative evidence for MS as a neural network disconnection syndrome consistent with cognitive impairment mechanisms and the confounding role of fatigue and depression-outlook from the Fourth Nordic MS symposium.

    PubMed

    van Ettinger-Veenstra, H

    2016-09-01

    The Fourth Nordic MS symposium served as a platform to present an overview over the rise and impact of cognitive impairment in people with MS, from early stages on, impairing their quality of life. After discussing MS and cognitive impairment symptoms, a review on the pathophysiology underlying cognitive impairment was given, followed by a talk on neuroimaging highlighting cortical reorganization in MS-affected brains. As a conclusion, therapy and treatment options were discussed. The symposium presented several cutting-edge research studies providing or testing working models that appear successful in predicting and explaining cognitive impairment in MS, such as the disconnection syndrome. PMID:27580899

  16. Characterization of the Human Pancreatic Islet Proteome by Two-Dimensional LC/MS/MS

    SciTech Connect

    Metz, Thomas O.; Jacobs, Jon M.; Gritsenko, Marina A.; Fontes, Ghislaine; Qian, Weijun; Camp, David G.; Poitout, Vincent J.; Smith, Richard D.

    2006-12-01

    Research to elucidate the pathogenesis of type 1 diabetes mellitus has traditionally focused on the genetic and immunological factors associated with the disease, and, until recently, has not considered the target cell. While there have been reports detailing proteomic analyses of established islet cell lines or isolated rodent islets, the information gained is not always easily extrapolated to humans. Therefore, extensive characterization of the human islet proteome could result in better understanding of islet biology and lead to more effective treatment strategies. We have applied a two-dimensional LC-MS/MS-based analysis to the characterization of the human islet proteome, resulting in the detection of 29,021 unique peptides corresponding to 4,925 proteins. As expected, major islet hormones (insulin, glucagon, somatostatin), beta-cell enriched secretory products (IAPP), ion channels (K-ATP channel), and transcription factors (PDX-1, Nkx 6.1, HNF-1 beta) were detected. In addition, significant proteome coverage of metabolic enzymes and cellular pathways was obtained, including the insulin signaling cascade and the MAP kinase, NF-κβ, and JAK/STAT pathways. This work represents the most extensive characterization of the human islet proteome to date and provides a peptide reference library that may be utilized in future studies of islet biology and type 1 diabetes.

  17. Research.

    ERIC Educational Resources Information Center

    Raudenbush, Stephen

    In May of 1999, the American Academy of Arts and Sciences hosted a conference on ways to improve the scientific quality of educational research. In medicine, thanks to work 40 years ago by 2 researchers, Howard Hyatt and Frederick Mosteller, the commitment of medical professionals to base their diagnoses and prescriptions on clinical trials in…

  18. LC-MS/MS analysis of steroids in the clinical laboratory.

    PubMed

    Keevil, Brian G

    2016-09-01

    Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful tool that is changing the way we analyse steroids in the clinical laboratory. It is already opening up the field of steroid analysis in endocrinology and is providing new applications for individual steroids and panels of steroids in different clinical conditions. LC-MS/MS is now well-accepted technology and is increasingly being used to replace problematic immunoassay methods because of greater sensitivity and specificity. Improved sample preparation, modern chromatography methods, and sensitive, faster scanning mass spectrometers have all played a role in improving LC-MS/MS. LC-MS/MS is also playing a key role in improving the quality of assays through the development of reference measurement procedures, characterisation of reference materials and multi-site calibration programmes. There is increasing interest in multiplexing steroid assays into panels of diagnostic tests to aid and improve the diagnosis and monitoring of disease. PMID:27131495

  19. How Many proteins are Missed in Quantitative proteomics Based on Ms/Ms sequencing Methods?

    PubMed Central

    Mulvey, Claire; Thur, Bettina; Crawford, Mark; Godovac-Zimmermann, Jasminka

    2014-01-01

    Current bottom-up quantitative proteomics methods based on MS/MS sequencing of peptides are shown to be strongly dependent on sample preparation. Using cytosolic proteins from MCF-7 breast cancer cells, it is shown that protein pre-fractionation based on pI and MW is more effective than pre-fractionation using only MW in increasing the number of observed proteins (947 vs. 704 proteins) and the number of spectral counts per protein. Combination of MS data from the different pre-fractionation methods results in further improvements (1238 proteins). We discuss that at present the main limitation on quantitation by MS/MS sequencing is not MS sensitivity and protein abundance, but rather extensive peptide overlap and limited MS/MS sequencing throughput, and that this favors internally calibrated methods such as SILAC, ICAT or ITRAQ over spectral counting methods in attempts to drastically improve proteome coverage of biological samples. PMID:25729266

  20. Book Trade Research and Statistics. Prices of U.S. and Foreign Published Materials; Book Title Output and Average Prices: 2001 Final and 2002 Preliminary Figures; Book Sales Statistics, 2002: AAP Preliminary Estimates; U.S. Book Exports and Imports:2002; Number of Book Outlets in the United States and Canada; Review Media Statistics.

    ERIC Educational Resources Information Center

    Sullivan, Sharon G.; Grabois, Andrew; Greco, Albert N.

    2003-01-01

    Includes six reports related to book trade statistics, including prices of U.S. and foreign materials; book title output and average prices; book sales statistics; book exports and imports; book outlets in the U.S. and Canada; and numbers of books and other media reviewed by major reviewing publications. (LRW)