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Sample records for mt blanc france

  1. A two century record of strontium isotopes from an ice core drilled at Mt Blanc, France

    NASA Astrophysics Data System (ADS)

    Burton, G. R.; Rosman, K. J. R.; Van de Velde, K. P.; Boutron, C. F.

    2006-08-01

    New techniques which allow small amounts of Sr to be reliably analysed [G.R. Burton, V.I. Morgan, C.F. Boutron, K.J.R. Rosman, High-sensitivity measurements of strontium isotopes in polar ice, Anal. Chim. Acta 469 (2002) 225-233] by TIMS (Thermal Ionisation Mass Spectrometry) have been used to measure the isotopic composition of Sr and the concentration of Rb and Sr at sub-nanogram per gram levels in a Mt Blanc snow and ice core. This two century time series of Sr isotopes is the first to be reported in an Alpine glacier. The Sr and Rb concentrations range from 3 ng/g to 20 pg/g and 1 ng/g to 10 pg/g, respectively, with higher concentrations evident in more recent times. This trend is consistent with that reported previously for other metals such as Cd, Cu and Zn [K. Van de Velde, C. Barbante, G. Cozzi, I. Moret, T. Bellomi, C. Ferrari, C. Boutron, Changes in the occurrence of silver, gold, platinum, palladium and rhodium in Mont Blanc ice and snow since the 18th century, Atmos. Environ. 34 (2000) 3117-3127; K. Van de Velde, C. Boutron, C. Ferrari, T. Bellomi, C. Barbante, S. Rudnev, M. Bolshov, Seasonal variations of heavy metals in the 1960s Alpine ice: sources versus meteorological factors, Earth Planet. Sci. Lett. 164 (1998) 521-533; K.J.R. Rosman, C. Ly, K. Van de Velde, C.F. Boutron, A two century record of lead isotopes in high altitude Alpine snow and ice, Earth Planet. Sci. Lett. 176 (2000) 413-424]. The 87Sr/ 86Sr ratios vary between 0.7020 and 0.7176 and display relatively larger variations in recent times which have been attributed to seasonal variations made evident by the increased sampling resolution available at shallower depths. No change with time is evident in this ratio which has a mean value of ˜ 0.712 and is similar to Glacial ice at Summit Greenland, suggesting that aerosols reaching Mt Blanc represent the same mixture of sources. Also, anthropogenic sources would appear to have the same isotopic ratio. The presence of Saharan dust in some

  2. Multi-decadal evolution of ice/snow covers in the Mont-Blanc massif (France)

    NASA Astrophysics Data System (ADS)

    Guillet, Grégoire; Ravanel, Ludovic

    2017-04-01

    Dynamics and evolution of the major glaciers of the Mont-Blanc massif have been vastly studied since the XXth century. Ice/snow covers on steep rock faces as part of the cryosphere however remain poorly studied with only qualitative descriptions existing. The study of ice/snow covers is primordial to further understand permafrost degradation throughout the Mont-Blanc massif and to improve safety and prevention for mountain sports practitioners. This study focuses on quantifying the evolution of ice/snow covers surface during the past century using a specially developed monoplotting tool using Bayesian statistics and Markov Chain Monte Carlo algorithms. Combining digital elevation models and photographs covering a time-span of 110 years, we calculated the ice/snow cover surface for 3 study sites — North faces of the Tour Ronde (3792 m a.s.l.) and the Grandes Jorasses (4208 m a.s.l.) and Triangle du Tacul (3970 m a.s.l.) — and deduced the evolution of their area throughout the XXth century. First results are showing several increase/decrease periods. The first decrease in ice/snow cover surface occurs between the 1940's and the 1950's. It is followed by an increase up to the 1980's. Since then, ice/snow covers show a general decrease in surface which is faster since the 2010's. Furthermore, the gain/loss during the increase/decrease periods varies with the considered ice/snow cover, making it an interesting cryospheric entity of its own.

  3. Evolution of hut access facing glacier shrinkage in the Mer de Glace basin (Mont Blanc massif, France)

    NASA Astrophysics Data System (ADS)

    Mourey, Jacques; Ravanel, Ludovic

    2016-04-01

    Given the evolution of high mountain environment due to global warming, mountaineering routes and huts accesses are more and more strongly affected by glacial shrinkage and concomitant gravity processes, but almost no studies have been conducted on this relationship. The aim of this research is to describe and explain the evolution over the last century of the access to the five alpine huts around the Mer de Glace glacier (Mont Blanc massif), the larger French glacier (length = 11.5 km, area = 30 km²), a major place for Alpine tourism since 1741 and the birthplace of mountaineering, by using several methods (comparing photographs, surveying, collecting historical documents). While most of the 20th century shows no marked changes, loss of ice thickness and associated erosion of lateral moraines generate numerous and significant changes since the 1990s. Boulder falls, rockfalls and landslides are the main geomorphological processes that affect the access, while the glacier surface lowering makes access much longer and more unstable. The danger is then greatly increased and the access must be relocated and/or equipped more and more frequently (e.g. a total of 520 m of ladders has been added). This questions the future accessibility to the huts, jeopardizing an important part of mountaineering and its linked economy in the Mer de Glace area.

  4. Kinematics and thermal conditions in the permafrost-affected rockwalls of the Aiguille du Midi (3842 m a.s.l., Mont Blanc massif, France)

    NASA Astrophysics Data System (ADS)

    Ravanel, Ludovic; Grangier, Germain; Weber, Samuel; Beutel, Jan; Magnin, Florence; Gruber, Stefan; Deline, Philip

    2016-04-01

    Processes that control climate-dependent rockfall from permafrost-affected rock slopes are still poorly understood. In this study, we present the results of a Wireless Sensor Network, integrated within the Swiss project PermaSense and developed in 2012, to measure rock temperature and geotechnical parameters in the steep rockwalls of the Aiguille du Midi (AdM, 3842 m a.s.l., Mont Blanc massif, France). Accessible year round by cable car, the AdM comprises two main peaks: (i) the Piton Nord with the cable car arrival station, where 4 crack-meters are placed on four major fractures, and (ii) the Piton Central with many touristic infrastructure, equipped with three 10-m-deep boreholes with 15 temperatures sensors since 2009, and where 2 crack-meters are installed along a major fracture. Three major kinematic regimes are observed: (i) opening of clefts when the rock temperature becomes positive, followed by closing during the cold period, (ii) summer opening continued by a winter opening, and (iii) closing during the warm period followed by opening in winter.

  5. GPS and TerraSAR-X time series measure temperate glacier flow in the Mont Blanc massif (France): the Argentière glacier test site.

    NASA Astrophysics Data System (ADS)

    Ponton, F.; Walpersdorf, A.; Gay, M.; Trouvé, E.; Mugnier, J. L.; Fallourd, R.; Cotte, N.; Ott, L.; Serafini, J.

    2012-04-01

    We present measurements of the surface velocity of the Argentière glacier in the Mont Blanc massif, France, obtained by SAR and GPS observations. We produce surface velocity fields from several couples of descending and ascending TerraSAR-X acquisitions repeated at 11 days intervals in spring 2009, using the offset power tracking technique. Moreover, we dispose of four years of GPS data acquired continuously on the Argentière glacier. Our local permanent GPS network is composed of two stations on the glacier at altitudes of 2441 m and 2770 m, and two stations in static places, one in the valley of Chamonix at an altitude of 1121 m and the other on a rock outcrop near the glacier at the altitude of 2835 m. The measurements yield average displacement rates of about 13 cm/day for the upper glacier station (2770 m) and 17 cm/day for the lower site (2441 m). These in situ GPS results have been used already to validate the displacement rates of a corner reflector on the glacier measured by SAR interferometry. Here, we will use the GPS observations to validate longitudinal profiles of the surface velocity field obtained by offset power tracking. The combination of continuous GPS time series and successive TerraSAR-X images yield new information on temperate glacier dynamics, constraining an annual variability of the displacement rates of up to 28 %, with fastest flow in late summer, and a spatial variability of the displacement rates of up to 50%, with fastest flow at the bottom of the glacier. The continuous monitoring (in space and time) of the Argentière glacier flow over several annual cycles can be used to examine the correlation with climatological parameters such as temperature and cumulated precipitations and provides an exceptional data set for improving models of temperate glacier flow mechanisms.

  6. The LIA history of the "Glacier des Bossons" (Mont Blanc area, France): a new high-resolution glacier length curve based on historical documents

    NASA Astrophysics Data System (ADS)

    Nussbaumer, Samuel U.; Zumbühl, Heinz J.

    2010-05-01

    Historical and proxy-records have documented a partly asynchronous evolution in temperature, precipitation and glacial variations between European regions during the Little Ice Age (LIA), and the causes of these temporal anomalies are yet being poorly understood. To address this question, highly resolved glacier reconstructions going far back in time based on historical documents (for the last 500 years) or on dendrochronological and radiocarbon dating (for the Holocene) are very important as they give valuable insights in past climate. However, such reconstructions exist only for few glaciers worldwide, depending on the public perception and the accessibility of the corresponding glacier and its surrounding area. One of these regions of interest is the well-documented Mont Blanc area. Here, we present a new high-resolution reconstruction of length changes for the "Glacier des Bossons", situated in the French part of the Mont Blanc area. This reconstruction is based on historical material newly discovered, that has not been evaluated so far for glacier reconstructions. More than 200, often unpublished, artworks (paintings, drawings, prints), photographs, maps and written accounts have been critically analysed and give an univocal picture of the glacier's history. Especially noteworthy are the drawings by Jean-Antoine Linck, Samuel Birmann and Eugène Viollet-le-Duc which depict meticulously the glacier's extent during the vast advance and subsequent retreat during the 19th century. The new reconstruction dates back to AD 1580. Maxima of the "Glacier des Bossons" are proved around 1610/1643, 1685, 1712, 1780, 1818, 1854, 1892, 1921, 1941, and 1983. The LIA maximum extent was reached in 1818. Until the present, the glacier has lost about 1.5 kilometres in length, and it is nowadays shorter than at any time during the reconstruction period. The length curve of the "Glacier des Bossons" is finally analysed regarding climate data and also compared with the nearby "Mer

  7. Chronological constraints on the Holocene glacier dynamics of the Argentière Glacier (Mont Blanc massif, France) based on cosmogenic nuclide dating

    NASA Astrophysics Data System (ADS)

    Protin, Marie; Schimmelpfennig, Irene; Mugnier, Jean-Louis; Ravanel, Ludovic; Deline, Philip; Le Roy, Melaine; Moreau, Luc; Aster Team

    2017-04-01

    While reconstruction of glacier fluctuations during the Holocene provides important information about the glacier response to natural climate change, it is still a challenge to accurately constrain chronologies of past glacier advances and retreats. Moraine deposits and roches moutonnées represent valuable geomorphic markers of advanced glacier extensions, while the currently ongoing glacier melt uncovers proglacial bedrock that can be used as a new archive to investigate the durations when a glacier was in retreated position during the Holocene. Our study focuses on the Mont-Blanc massif (MBM), located in the Western Alps and hosting some of the largest glaciers of Europe. Chronologies of Holocene glacier fluctuations in this area are still sparse, even if recent studies considerably improved the temporal reconstruction of Holocene advances of some glaciers in the MBM and locations near-by (e.g. Le Roy et al., 2015). Here we present preliminary 10Be exposure ages obtained from moraine boulders, roches moutonnées and pro- and subglacial bedrock in the area of the Argentière Glacier, located on the north-western flank of the MBM. The ages of moraine boulders and roche moutonnée surfaces outboard of the investigated moraines suggest that the Early Holocene deglaciation of this area started around 11 ka ago. Also, 10Be measurements of recently deglaciated bedrock surfaces indicate that the glacier was at a position at least as retracted as today for a minimum duration of 7 ka throughout the Holocene. The 10Be measurement of one sample from a surface that is currently still covered by 60 m of ice suggests that the glacier was shorter than today for at least a duration of 3 ka. These first results will soon be completed with in situ 14C measurements, which will allow us to quantify and take into account subglacial erosion rates and thus to more accurately determine the cumulative duration of pro- and subglacial bedrock exposure during the Holocene.

  8. Basal icequakes recorded beneath an Alpine glacier (Glacier d'Argentière, Mont Blanc, France): Evidence for stick-slip motion?

    NASA Astrophysics Data System (ADS)

    Helmstetter, Agnès.; Nicolas, Barbara; Comon, Pierre; Gay, Michel

    2015-03-01

    While basal icequakes associated with glacier motion have been detected under Antarctica for several decades, there remains very little evidence of stick-slip motion for Alpine glaciers. Here we analyzed 2357 basal icequakes that were recorded at Glacier d'Argentière (Mont-Blanc Massif) between February and November of 2012 and that are likely to be associated with basal sliding. These events have been classified into 18 multiplets, based on their waveforms. The strong similarity of the waveforms within each multiplet suggests an isolated repeating source. Despite this similarity, the peak amplitude within each multiplet varies gradually in time, by up to a factor of 18. The distribution of these events in time is relatively complex. For long time scales, we observe progressive variations in the amplitudes of events within each multiplet. For intermediate time scales (hours), the events occur regularly in time, with typical return times of several minutes up to several hours. For short time scales (from 0.01 to 100 s), the largest multiplet shows clustering in time, with a power law distribution of the interevent times. The location of these events and their focal mechanisms are not well constrained, because most of these events were detected by a single seismometer. Nevertheless, the locations can be estimated with an accuracy of a few tens of meters using a polarization analysis. The estimated average depth of the basal events is 179 m, which is in good agreement with the estimated glacier thickness. The relative changes in distance between the source and the sensor can be measured accurately by correlating separately the P wave and S wave parts of the seismograms of each event with the template waveforms, which are obtained by averaging the signals within each multiplet. We observed small variations in the times between the P wave and the S wave of up to 0.6 ms over 50 days. These variations cannot be explained by displacement of the sensor with respect to the

  9. Surface-to-base transfer and subglacial hydrology controls on subglacial erosion evidenced from 7 years of hydro-sedimentary observations within Bossons glacier catchment (Mont-Blanc massif, France)

    NASA Astrophysics Data System (ADS)

    Guillon, Hervé; Mugnier, Jean-Louis; Buoncristiani, Jean-François

    2016-04-01

    Continuous monitoring of sediment load in proglacial rivers allows to quantify the mass of sediment exported from a glaciated catchment toward the fluvial system. However, supraglacial, subglacial and proglacial sources contribute to this export and their specific roles are poorly understood. Our general intent in this study is to understand their respective contribution to the total exported load of suspended sediment. The catchment of the rapidly retreating Bossons glacier (Mont-Blanc massif, France) provides an ideal field laboratory to infer about the intensity of present-day erosion processes. On this glacier, two proglacial rivers were monitored : Crosette stream and Bossons stream. For Bossons stream, completing the initial 2009-2010 data, discharge and sediment load have been measured from 2011 to 2015 at a high time resolution (timestep from 15 to 2 min). Two stations acquired these data, upstream and downstream, respectively, from a valley sandur located at ˜1 km from the glacial tongue. Crosette stream was monitored directly at the exit of the subglacial system during 2013 and 2014. The combined dataset currently available from these 3 stations spans 7 years from 2009 to 2015, is not only limited to the melt season duration and is appreciably rich (4.3 millions raw data points). This tremendous data profusion allowed developping statistical methods. Multi-linear models were used to investigate sediment transfer processes in the proglacial area during the 2013 melt season. An original probabilistic approach provided critical information for every other years. Uncertainties on sediment masses were assessed by a careful propagation and by a Monte-Carlo method. Additionnaly, sediment transfer from supraglacial to subglacial position has been estimated for Crosette and Bossons streams. Applying the conclusions of these previous works on the 7 years dataset, we provide erosion rates for the supraglacial rockwalls, subglacial bedrock and proglacial area

  10. Multi-stage melt-rock interaction in the Mt. Maggiore (Corsica, France) ophiolitic peridotites: microstructural and geochemical evidence

    NASA Astrophysics Data System (ADS)

    Rampone, Elisabetta; Piccardo, Giovanni B.; Hofmann, Albrecht W.

    2008-10-01

    Spinel and plagioclase peridotites from the Mt.Maggiore (Corsica, France) ophiolitic massif record a composite asthenosphere-lithosphere history of partial melting and subsequent multi-stage melt-rock interaction. Cpx-poor spinel lherzolites are consistent with mantle residues after low-degree fractional melting ( F = 5-10%). Opx + spinel symplectites at the rims of orthopyroxene porphyroclasts indicate post-melting lithospheric cooling ( T = 970-1,100°C); this was followed by formation of olivine embayments within pyroxene porphyroclasts by melt-rock interaction. Enrichment in modal olivine (up to 85 wt%) at constant bulk Mg values, and variable absolute REE contents (at constant LREE/HREE) indicate olivine precipitation and pyroxene dissolution during reactive porous melt flow. This stage occurred at spinel-facies depths, after incorporation of the peridotites in the thermal lithosphere. Plagioclase-enriched peridotites show melt impregnation microtextures, like opx + plag intergrowths replacing exsolved cpx porphyroclasts and interstitial gabbronoritic veinlets. This second melt-rock interaction stage caused systematic chemical changes in clinopyroxene (e.g. Ti, REE, Zr, Y increase), related to the concomitant effects of local melt-rock interaction at decreasing melt mass, and crystallization of small (<3%) trapped melt fractions. LREE depletion in minerals of the gabbronoritic veinlets indicates that the impregnating melts were more depleted than normal MORB. Preserved microtextural evidence of previous melt-rock interaction in the impregnated peridotites suggests that they were progressively uplifted in response to lithosphere extension and thinning. Migrating melts were likely produced by mantle upwelling and melting related to extension; they were modified from olivine-saturated to opx-saturated compositions, and caused different styles of melt-rock interaction (reactive spinel harzburgites, vs. impregnated plagioclase peridotites) depending on the

  11. France

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Every July, the world's best cyclists race more than 3500 km around France, and sometimes the surrounding countries, in the Tour de France. This image from the Moderate resolution Imaging Spectroradiometer (MODIS) shows the varied terrain which challenges the riders. The race started in western France at Futuroscope, and headed toward Brittany. In these mostly flat 'stages' (as each day's race is called) sprinting specialists usually dash for the finish out of the main pack of riders. The race then moved to the Pyrenees mountains, in southern France along the border with Spain. Climbers and the overall favorites shine in the mountains, often gaining 10 minutes or more on their rivals. Only a few days after the Pyrenees climbs the race was again in the mountains. First Mont Ventoux, an extinct volcano in Provence, and then the massive Alps, with altitudes as high as 2,645 meters, challenged the racers. Finally the race headed toward Paris and a July 23rd finish in Paris. Go Lance! To learn more about MODIS, visit the MODIS web. Image by Jacques Descloitres, MODIS Land group, NASA GSFC

  12. France.

    PubMed

    1993-02-10

    Taxes on cigarettes in France have been increased by 15 per cent, the first of an overall rise of 30 per cent. Part of the revenue raised will help subsidise motor racing which lost its sponsors following a recent national ban on cigarette advertising. The remainder will go to the social security service.

  13. France

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Every July, the world's best cyclists race more than 3500 km around France, and sometimes the surrounding countries, in the Tour de France. This image from the Moderate resolution Imaging Spectroradiometer (MODIS) shows the varied terrain which challenges the riders. The race started in western France at Futuroscope, and headed toward Brittany. In these mostly flat 'stages' (as each day's race is called) sprinting specialists usually dash for the finish out of the main pack of riders. The race then moved to the Pyrenees mountains, in southern France along the border with Spain. Climbers and the overall favorites shine in the mountains, often gaining 10 minutes or more on their rivals. Only a few days after the Pyrenees climbs the race was again in the mountains. First Mont Ventoux, an extinct volcano in Provence, and then the massive Alps, with altitudes as high as 2,645 meters, challenged the racers. Finally the race headed toward Paris and a July 23rd finish in Paris. Go Lance! To learn more about MODIS, visit the MODIS web. Image by Jacques Descloitres, MODIS Land group, NASA GSFC

  14. France.

    PubMed

    1987-09-01

    In 1986, France had a population of 55,493,000, with an annual growth rate of 0.4%. The infant mortality rate stood at 8.2/1000. Of the work force of 23.8 million, 8.3% were engaged in agriculture, 45.2% were in the industry and commerce sector, and 46.5% were engaged in services. The unemployment rate stood at 10.7%. The country's gross domestic product (GDP) was US$724 billion in 1986, with an average annual growth rate of 2.0%, and per capita income averaged $13,046. France has substantial agricultural resources, a diversified modern industrial system, and a highly skilled labor force. Following the return of a socialist majority in government in 1981, several large manufacturing firms were nationalized along with much of the commercial banking sector. Initial socialist policies were stimulative, relying partly on income redistribution and partly on increased government spending. However, the resultant increase in import demand was not offset by an increased demand French exports. In 1983, an economic stabilization plan of reductions in the budget deficit, involving spending cuts, increased taxes, and tighter monetary and credit policies, was successfully implemented. Although current economic policies should promote stronger growth over the medium to long term, trade competitiveness remains weak and high unemployment is a major social problem.

  15. Contained events in the Mont-Blanc nucleon stability experiment

    NASA Astrophysics Data System (ADS)

    Battistoni, G.; Campana, P.; Chiarella, V.; Ciocio, A.; Iarocci, E.

    1986-04-01

    The nucleon-stability experiment (NUSEX) underway at Mt. Blanc Laboratory is briefly described, and some preliminary results are reported. NUSEX is designed to both generate nucleons and detect eventual nucleon decays, and comprises 136 1-cm-thick iron sheets interleaved with limited streamer tubes and arranged in a 3.5-m cube; the active mass for nucleon decay is about 130 tons. During 22,350 h of live time (equivalent to 2.3 x 10 to the 32nd nucleon yr) up to April 1985, 30 contained events were recorded (22 attributed to numu and seven attributed to nue), corresponding to a neutrino interaction rate of 149 + or - 27/kton yr.

  16. The Mont Blanc detection of neutrinos from SN 1987A.

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.; Dadykin, V. L.; Fulgione, W.; Galeotti, P.; Kalchukov, F. F.; Kortchaguin, V. B.; Kortchaguin, P. V.; Malguin, A. S.; Ryassny, V. G.; Ryazhkaya, O. G.; Saavedra, O.; Talochkin, V. P.; Trinchero, G.; Vernetto, S.; Zatsepin, G. T.; Yakushev, V. F.

    The authors discuss the event detected in the Mont Blanc Underground Neutrino Observatory on February 23, 1987, during the occurrence of supernova SN 1987A. The pulse amplitudes, the background imitation probability, and the energetics connected with the event are reported. It is also shown that some interactions recorded at the same time in other underground experiments, with a lower detection efficiency, are consistent with the Mont Blanc event.

  17. French Alps, Mont Blanc, French/Italian Border

    NASA Image and Video Library

    1992-04-02

    In this southeast looking view, Mont Blanc, on the French/Italian border, (48.0N, 4.5E) the highest mountain peak in all of Europe, is just below and right of center (below the end of the prominent valley of the Aosta River, in the center of the photo. The rivers flow out of the Alps into Italy toward Turin. Chamonix, the famous resort town and center of Alpine mountain climbing, lies in the valley just below Mont Blanc.

  18. Geographical origin of Sauvignon Blanc wines predicted by mass spectrometry and metal oxide based electronic nose.

    PubMed

    Berna, Amalia Z; Trowell, Stephen; Clifford, David; Cynkar, Wies; Cozzolino, Daniel

    2009-08-26

    Analysis of 34 Sauvignon Blanc wine samples from three different countries and six regions was performed by gas chromatography-mass spectrometry (GC-MS). Linear discriminant analysis (LDA) showed that there were three distinct clusters or classes of wines with different aroma profiles. Wines from the Loire region in France and Australian wines from Tasmania and Western Australia were found to have similar aroma patterns. New Zealand wines from the Marlborough region as well as the Australian ones from Victoria were grouped together based on the volatile composition. Wines from South Australia region formed one discrete class. Seven analytes, most of them esters, were found to be the relevant chemical compounds that characterized the classes. The grouping information obtained by GC-MS, was used to train metal oxide based electronic (MOS-Enose) and mass spectrometry based electronic (MS-Enose) noses. The combined use of solid phase microextraction (SPME) and ethanol removal prior to MOS-Enose analysis, allowed an average error of prediction of the regional origins of Sauvignon Blanc wines of 6.5% compared to 24% when static headspace (SHS) was employed. For MS-Enose, the misclassification rate was higher probably due to the requirement to delimit the m/z range considered.

  19. Results of the liquid scintillation detector of the Mont Blanc Laboratory

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Badino, G.; Bologna, G. F.; Castagnoli, C.; Fulgione, W.

    1986-04-01

    Preliminary results research on collapsing-star neutrino bursts and cosmic-ray muons, obtained using the 90-ton 72 element liquid-scintillation detector (LSD) at Mt. Blanc Laboratory since October 1984, are presented in tables and graphs and characterized. The theoretically expected energy and time values for neutrinos from collapsing stars of 2 solar mass are calculated, and it is shown that no burst with multiplicity 6 or greater and Delta t 30 s or less was detected in 4 mo of LSD live time, corresponding to a preliminary upper limit of 3/yr for Galactic stellar collapses. About 3 muons/h crossing at least two counters were observed, and detection of aobut 700 muon bundles per year of multiplicity 2 or greater or 90 bundles per year of multiplicity 3 or greater is predicted. The possible use of the LSD to search for nucleon instability (proton decay into muons) is considered.

  20. Wind-driven surface circulation in the Cape Blanc region

    NASA Astrophysics Data System (ADS)

    Castellanos, P.; Pelegrí, J. L.; Benazzouz, A.

    2013-06-01

    We analyze the short-term transition, on time scales of the order of days and weeks, of the surface fields in the coastal transition zone off Northwest Africa, between 15°N and 25°N, during winter and spring 2005 and 2006. This is a complex region characterized by the baroclinic coastal jet north of Cape Blanc, along-shore convergence and water export at the Cape Blanc giant filament, and substantial mesoscale variability between Capes Verde and Blanc. We use the anomalies of the wind impulse and two different coastal upwelling indexes, evaluated off 17°N, 20°N and 23°N, in order to assess the importance of wind forcing in this short-term variability. We also employ daily and weekly surface maps of wind, temperature, surface height and currents to investigate which are the mechanisms that lead to the relatively fast changes in the flow patterns. The coastal baroclinic jet and the Cape Blanc giant filament are ubiquitous features, the two being intrinsically related through the intensity of upwelling off Cape Blanc. Therefore, the strength of both features responds, to a large extent, to the fluctuations of the northeasterly winds; their intensity is greater in spring than winter but during both seasons they experience relatively fast oscillations related to the intermittency of the wind field. The mesoscalar features are visible in the entire domain, with time scales typically of the order of two weeks, but become prominent in the southern region during spring, apparently related to an intense northward coastal jet south of Cape Blanc.

  1. Mise en évidence de déformations en faille inverse avec ruptures de surface cosismiques dans des dépôts colluviaux würmiens du versant nord du mont Ventoux (Provence occidentale, France)Evidence of reverse faulting and coseismic surface ruptures in Würm colluvial deposits from the Mt Ventoux northern slope (Western Provence, France)

    NASA Astrophysics Data System (ADS)

    Dutour, Alain; Philip, Hervé; Jaurand, Erwan; Combes, Philippe

    In western Provence (France), brittle deformation of Quaternary age occurring in the vicinity of the Nı̂mes and Durance faults has been linked to palaeoseisms of significant magnitude. Our new observations made on the southern rim of the Tertiary Malaucène Basin, in the continuation of a thrust to the north of Mt Ventoux, present evidence for reverse faulting deformation in deposits of a Würm colluvial fan. The analysis of a trench section provides clear evidence for: (1) the development of two successive surface ruptures and degradation of associated scarps during the Mid-Upper Würm, and, (2) the continuation of the reverse fault within the Oligocene basement. These tectonic events were associated with earthquakes of at least 6 in magnitude. To cite this article: A. Dutour et al., C. R. Geoscience 334 (2002) 849-856.

  2. Neutrino astronomy at Mont Blanc: from LSD to LSD-2.

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.; Dadykin, V. L.; Fulgione, W.; Galeotti, P.; Kalchukov, F. F.; Kortchaguin, V. B.; Kortchaguin, P. V.; Malguin, A. S.; Ryassny, V. G.; Ryazskaya, O. G.; Saavedra, O.; Talockin, V. P.; Trinchero, G.; Vernetto, S.; Zatsepin, G. T.; Yakushev, V. F.

    In this paper the authors present the upgrading of the LSD experiment, presently running in the Mont Blanc Laboratory. The data recorded during the period when supernova 1987A exploded are analysed in detail. The research program of LSD-2, the same experiment as LSD but with a higher sensitivity to search for neutrino bursts from collapsing stars, is also discussed.

  3. Search for neutrinos from collapsing stars at Mont Blanc.

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.; Dadykin, V. L.; Fulgione, W.; Galeotti, P.; Kalchukov, F. F.; Kortchaguin, V. B.; Kortchaguin, P. V.; Malguin, A. S.; Ryassny, V. G.; Ryazskaya, O. G.; Saavedra, O.; Talockin, V. P.; Trinchero, G.; Vernetto, S.; Zatsepin, G. T.; Yakushev, V. F.

    The authors present the upgrading of the LSD experiment, presently running in the Mont Blanc Laboratory. The data recorded during the period when supernova 1987A exploded are analysed in detail. The research program of LSD-2, the same experiment as LSD but with an higher sensitivity to search for neutrino bursts from collapsing stars, is also discussed.

  4. The Mont Blanc detector of neutrinos from collapsing stars.

    NASA Astrophysics Data System (ADS)

    Saavedra, O.

    The author describes the upgrading of the LSD experiment presently running in the Mont Blanc Laboratory, and the research program of LSD-2, the same experiment as LSD but with a higher sensitivity to search for neutrino bursts from collapsing stars.

  5. Limit on monopole flux in the Mount Blanc NUSEX experiment

    NASA Astrophysics Data System (ADS)

    Battistoni, G.; Bloise, C.; Campana, P.; Ciocio, A.; Iarocci, E.

    1986-04-01

    A trigger dedicated to the search for superheavy monopoles has operated for about two years in the NUSEX apparatus installed in the Mont Blanc tunnel. Monopoles are identified by time of flight and visualization of the pulses involved in a trigger. The present upper limit on monopole flux is 2.3 x 10 to the -13th/sq cm s sr (90-percent confidence level).

  6. Mt. Everest

    NASA Image and Video Library

    1994-09-30

    STS068-259-009 (30 September-11 October 1994) --- This south-looking, summer-time view of Mt. Everest (center) - with strong sense of three dimension because of reduced amount of snow - and neighboring peaks of the Himalayas. Clouds cover lower slopes in India.

  7. The neutrino burst from SN 1987A detected in the Mont Blanc LSD experiment.

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.; Dadykin, V. L.; Fulgione, W.; Galeotti, P.; Kalchukov, F. F.; Khalchukov, F. F.; Kortchaguin, V. B.; Korchagin, V. B.; Kortchaguin, P. V.; Korchagin, P. V.; Malguin, A. S.; Mal'Gin, A. S.; Ryassny, V. G.; Ryasnyj, V. G.; Ryazhkaya, O. G.; Saavedra, O.; Talochkin, V. P.; Trinchero, G.; Vernetto, S.; Zatsepin, G. T.; Yakushev, V. F.

    The authors discuss the event, (5 interactions recorded during 7 seconds) detected in the Mont Blanc Underground Neutrino Observatory on February 23, 1987, during the occurrence of supernova SN 1987A. The pulse amplitudes, the background imitation probability, and the energetics connected with the event are reported. It is also shown that some interactions recorded at the same time in other underground experiments, with a lower detection efficiency, are consistent with the Mont Blanc event.

  8. Reconstruction of the rock fall/avalanche frequency in the Mont Blanc massif since the Last Glacial Maximum. New results using 10Be cosmogenic dating and reflectance spectroscopy

    NASA Astrophysics Data System (ADS)

    Gallach, Xavi; Ogier, Christophe; Ravanel, Ludovic; Deline, Philip; Carcaillet, Julien

    2017-04-01

    ., Brandová, D., Haeberli, W., Ivy-Ochs, S., Christl, M., Kubik, P.W., Deline, P. (2008). Comparison of exposure ages and spectral propierties of rock surfaces in steep, high alpine rock walls of Aiguille du Midi, France. Proceedings of the 9th International Conference on Permafrost, 143-148. Gallach, X. et al. (submitted). Timing of rockfalls in the Mont Blanc massif (western Alps). Evidences from surface exposure dating with cosmogenic 10Be. Landslides.

  9. Comprehensive lipidome profiling of Sauvignon blanc grape juice.

    PubMed

    Tumanov, Sergey; Zubenko, Yuri; Greven, Marc; Greenwood, David R; Shmanai, Vadim; Villas-Boas, Silas G

    2015-08-01

    This study presents a comprehensive lipidome analysis of Sauvignon blanc grape juice by combining GC-MS based fatty acid profiling with shotgun lipidomics strategy. We observed that despite grape juice being a water based matrix it contains a diverse range of lipid species, including common saturated and unsaturated free and intact fatty acids as well as odd-numbered and hydroxy fatty acids. Based on GC-MS quantitative data, we found that the total lipid content of grape juice could be as high as 2.80 g/L. The majority of lipids were present in the form of complex lipids with relatively small amount of free fatty acids (<15%). Therefore we concluded that the lipidome should be considered an important component of grape juice with the potential to impact on fermentation processes as well as on the sensorial properties of fermented products. This work serves as a hypothesis generating tool, the results of which justify follow-up studies to explore the influence of the grape juice lipidome and lipid metabolism in yeast on the aroma profile of wine. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Reconstruction of glacier fluctuations in the Mont-Blanc massif, western Alps: a multi-­-method approach

    NASA Astrophysics Data System (ADS)

    Lehmann, Benjamin; Valla, Pierre G.; King, Georgina E.; Ivy-Ochs, Susan; Christl, Marcus; Herman, Frederic

    2017-04-01

    Providing tight spatial and temporal constraints on Late Pleistocene glacier fluctuations remains an important challenge for understanding glacier and glacial erosion responses to climatic change. Paleo-glacier reconstructions are often scarce, discrete and spatially-limited during the Lateglacial and Holocene times, which makes their use as a paleoclimate proxy sometimes challenging. Here we focus on the Mer de Glace glacier (Mont-Blanc massif, France) where glacier reconstructions over the Little Ice Age (LIA, Vincent et al. 2014) and since the Mid Holocene (Le Roy et al., 2015) reveal important glacier fluctuations and ice thickness variations. LGM trimline mapping (Coutterand et al., 2006) and cosmogenic 10Be exposure dating on the Italian side of the massif (Wirsig et al., 2016) give important indications on the maximum ice thickness at the LGM and the timing of ice surface lowering in this area. However, continuous records of the Mer de Glace fluctuations have to precisely constrained to provide valuable record of local climate and erosion with time. Therefore, we collected samples of granitic polished bedrock surfaces between the LGM ice surface ( 2505 m a.s.l, Coutterand et al., 2006) and the present-day glacier (1920 m a.s.l) covering 600 m of elevation for the ice surface fluctuations. We first used cosmogenic 10Be dating on quartz (Gosse and Phillips, 2001) to constrain ice surface fluctuations during the Lateglacial and Holocene. Given that cosmic rays exposure produces 10Be over the first 3 m below the rock surface, multiple exposure history from complex glacier fluctuations would be difficult to quantify using this chronometer. To improve the temporal resolution for such complex exposure history, we combined cosmogenic 10Be dating on quartz with OSL surface exposure dating (Sohbati et al., 2011). OSL surface exposure dating is sensitive to light, based on the progressive bleaching of the OSL signal in a rock sample that depends on its exposure time

  11. Monitoring the morphological evolution of complex glaciers: the Planpincieux case-study (Mont Blanc - Aosta Valley)

    NASA Astrophysics Data System (ADS)

    Giordan, Daniele; Manconi, Andrea; Allasia, Paolo; Curtaz, Michèle; Vagliasindi, Marco; Bertolo, Davide

    2014-05-01

    The Planpincieux Glacier (PG) is located on the Italian side of the Grandes Jorasses massif, Mont Blanc, Italy. This area is historically known for the occasional activation of ice falls events from the frontal part of the glacier. The PG is a so-called "polythermal" glacier, meaning that the liquid water present at contact between ice and the bedrock in the lower part of the glacier itself plays an important role in the glacier dynamics, and ice falls might occur in a sudden and unpredictable fashion. In this scenario, the accurate analysis of the glacier morphological evolution assumes a crucial role. Starting from 2012, within the framework of the regional plan for glaciers risk detection, a research project was set up to study the Planpincieux Glacier and evaluate the potential hazard concerning the possible activation of large ice or ice-snow avalanches triggered by icefall events in that area. Dynamics of such avalanches, as well as potentially endangered areas, have been evaluated in an expertise by the SLF Institute. Therefore, the availability of both qualitative information and quantitative measurements relevant to the glacier movements represented a primary goal. After a careful evaluation of several possible technical solutions to achieve displacement monitoring also based on the results of a preliminary study managed by the ETH Zurich (prof. M. Funk), we installed an experimental monitoring station located on the opposite side of the valley, at the top of the Mt. de la Saxe, ca. 3.5 km away from the main target. The monitoring station is composed of two modules, including: (i) a surveillance module, based on a medium resolution digital camera, observing large part of the slope; (ii) a photogrammetric module, based on a high resolution digital camera equipped with a 300mm optical zoom, pointed on the Planpincieux glacier front. At this stage, our analyses focused mainly on the qualitative assessment and recognition of impulsive phenomena affecting the

  12. Chateaubriant, France

    NASA Image and Video Library

    2010-03-08

    This image, acquired 11-05-2007 by NASA Terra spacecraft, shows the city of Chateaubriant, France, surrounded by very old farmsteads. The surrounding countryside presents an interesting pattern of randomly oriented, small individual farmsteads.

  13. Microbiological fingerprint of African dust deposition in alpine snow pack, Mont Blanc summit

    NASA Astrophysics Data System (ADS)

    Chuvochina, Maria; Alekhina, Irina; Normand, Philippe; Petit, Jean-Robert; Bulat, Sergey

    2010-05-01

    The biogeochemical effect of African dust transport has been reported mostly with respect to nutrient budget change in both terrestrial and aquatic ecosystems and global transport of microorganisms, including pathogens. However, its potential to seed or colonize the remote environments by transported microorganisms is poorly understood. This study has focused on bacterial content and diversity of Saharan dust deposition from 2006, 2008 and 2009 in snow pack of Mont Blanc (MtBl) glacier as well as recognition of bacteria which could be involved in establishing microbiota in this icy environment. Four snow samples recorded Saharan dust events from June 2006 (SDm06/2006 - 3,5 months aged), May and June 2008 (SDm05/2008 and SDm06/2008 - 1 month in between and 1 week aged each) and May 2009 (SDm05/2009 - 1 week aged) were collected at Col du Dome area (4250m a.s.l.). Bacterial community structure was assessed by ribotyping and subsequent sequencing of bacterial 16S rRNA genes. To exclude human-associated and laboratory contamination several controls were run in parallel updating our contaminant library. The obtained phylotypes were tested against this library keeping only those which successfully passed through this exam. Of 176 selected clones from four clone libraries 29.8% were met in our contaminant library. The ‘true' sequences were assigned to 57 phylotypes (>97.5% sequence similarity) originating mostly from soil. The prevalent phylotypes recovered were belonging to different bacterial divisions: Deinococcus-Thermus, Alpha-proteobacteria and CFB groups for SDm06/2006; Actinobacteria, Alpha-proteobacteria and CFB for SDm05/2008 and SDm06/2008; Actinobacteria and chloroplasts/plastids for SDm05/2009. Phylogenetic analysis of all phylotypes showed no shared species amongst all 4 dust layers in MtBl snow pack in 2006, 2008 and 2009. However, two phylotypes (Blastococcus saxobsidens sp. - 99%, Geodermatophilus obscurus sp. - 99%) were shared between 2008 and 2009

  14. Large solar flares - Analysis of the events recorded by the Mont Blanc neutrino detector

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.; Dadykin, V. L.; Fulgione, W.; Galeotti, P.; Kalchukov, F. F.; Korolkova, I. V.; Kortchaguin, P. V.; Kudryavtsev, V. A.; Malguin, A. S.; Periale, L.; Ryassny, V. G.; Ryazhskaya, O. G.; Saavedra, O.; Trinchero, G.; Vernetto, S.; Yakushev, V. F.; Zatsepin, G. T.

    1991-11-01

    Analytical results are discussed from events recorded by the Mont Blanc neutrino detector during 19 large solar flares from August 1988 to March 1990, including the powerful flares of September 29 and October 19, 1989. It is found that no significant neutrino signal coincides temporally with solar flares. Upper limits are obtained for the integral neutrino and antineutrino flux of different flavors.

  15. Microbial communities established on Mont Blanc summit with Saharan dust deposition

    NASA Astrophysics Data System (ADS)

    Chuvochina, M.; Alekhina, I.; Normand, P.; Petit, J. R.; Bulat, S.

    2009-04-01

    Dust originating from the Sahara desert can be uplifted during storms, transported across the Mediterranean towards the Alpine region and deposited during snowfalls. The microbes associated with dust particles can be involved in establishing microbiota in icy environments as well as affect ecosystem and human health. Our objective was to use a culture-free DNA-based approach to assess bacterial content and diversity and furthermore, to identify ‘icy' microbes which could be brought on the Mont Blanc (MtBl) summit with Saharan dust and became living in the snow. Saharan dust fallout on MtBl summit from one event (MB5, event June 2006) vs. control libraries and that from another event (May 2008) were collected in Grenoble (SD, 200 m a.s.l.) and at Col du Dome (MB-SD, 4250 m a.s.l.). Soil from Ksar Ghilane (SS, Saharan desert, Tunisia, March 2008) was taken for overall comparison as a possible source population. Fresh snow falling in Grenoble (85) was collected as example of diversity in this area. To assess the microbial diversity 16S rRNA gene libraries (v3-v5 region) were constructed for corresponding dust-snow samples (MB5, SS, SD, 85 and MB-SD) along with clear snow samples and several controls. For both MB5 and MB-SD samples full-gene technique was evoked in attempt to differentiate reproduced bacteria from damaged DNA. Before sequencing the clones were rybotyped. All clone libraries were distinct in community composition except for some single phylotypes (or closely related groups) overlap. Thus, clone libraries from two different events that were collected at Col du Dome area within 2 year interval (MB5 and MB-SD) were different in community composition except one of the abundant phylotype from MB-SD library (Geodermatophilus sp.) which was shared (98% sequence similarity) with single representative from MB-5 library. These bacteria are pigmented and radiation-resistant, so it could be an indicator of desert origin for our sequences. For MB5 library two

  16. A fresh look at Bass Islands through Bois Blanc distribution, structure, and trap potential, Erie County Pennsylvania

    SciTech Connect

    Hobson, J.P. Jr.; Pees, S.T.

    1995-09-01

    Subsurface Upper Silurian and Lower Devonian strata have been correlated and mapped through a 55 sq. mi. (143 sq. km.) area of dense well control in Waterford and LeBoeuf Townships. Mapped strata include the Bass Islands. Helderberg, Oriskany and Bois Blanc Formation. The latter thicken in areas where {open_quotes}B{close_quotes} salt is absent. In most of LeBoeuf Township the Oriskany and Helderberg are absent and the Bois Blanc rests directly by unconformity on Bass Islands dolomite. In Waterford Township the Oriskany and Helderberg are generally present below pre-Bois Blanc and pre-Oriskany unconformities. Structural closure on the nose in Bois Blanc and Oriskany sandstones is provided by the combination of structural and stratigraphic factors and good gas shows have been tested from the formations.

  17. Monitoring surface displacements of glaciers with ground based photogrammetry: insights from Planpincieux Glacier, Grandes Jorasses massif, Mont Blanc

    NASA Astrophysics Data System (ADS)

    Manconi, Andrea; Dell'Anese, Federico; Giordan, Daniele; Allasia, Paolo; Curtaz, Michèle; Vagliasindi, Marco; Bertolo, Davide

    2015-04-01

    Monitoring the spatial and temporal evolution of glaciers modifications in a climate change scenario is a major scientific problem. The Italian side of the Grandes Jorasses massif, Mont Blanc, is historically known for the occasional activation of icefalls events from the frontal part of the glaciers located on that area. The Planpincieux Glacier (PG) is a "polythermal" glacier, meaning that the liquid water present at the contact between ice and the bedrock in the lower part of the glacier itself plays an important role in its dynamics. Under these conditions icefalls might occur in a sudden and barely predictable manner. In this scenario, an accurate analysis of its morphological evolution is crucial; however, one of the major problems on PG is the limited access to perform direct measurements. For this reason, remote sensing has been identified as the more convenient approach to achieve quantitative measurements of surficial modifications. An experimental monitoring station was installed on August 2013 in order to monitor the surface displacements at PG. The monitoring station is located on the opposite side of the valley, at the top of the Mt. de la Saxe, ca. 3.5 km away from the target under investigation. Monitoring includes: (i) a surveillance module, based on a medium resolution digital camera, observing large part of the slope; (ii) a photogrammetric module, based on a high resolution digital camera equipped with a 300 mm optical zoom, pointed to the PG front. Digital images acquired by the monitoring station are acquired with a revisit time of 1-hour, and analyzed by considering change-detection and pixel-offset techniques. This approach allows to evaluate surface changes over time, as well as to retrieve quantitative measurements of the glacier displacements. Here we present the results after one year of monitoring, and we discuss how the combination of different remote sensing techniques can be exploited for a better understanding of the glacier

  18. The PermaFRANCE network

    NASA Astrophysics Data System (ADS)

    Schoeneich, Philippe

    2010-05-01

    A French long term monitoring network of permafrost and frost related processes, named PermaFRANCE, is being built since two years. It will represent the French contribution to the Alpine wide PermaNET network. The PermaFRANCE network will focus not only on permafrost, but on all frost related phenomena at different altitudinal levels, including both thermal monitoring and process observation and monitoring : 1) continuous and discontinuous permafrost in rock walls : - thermal monitoring is mainly performed at the Aiguille du Midi (Mont Blanc massif) and includes rock surface temperature (RST) and temperature profils in medium depth boreholes (10 m) ; - inventory and observation of rockfall activity in high mountain rock walls : this action concerns the whole Mont Blanc area and is based on a hitorical inventory and an observation of current activity based on a network of observers and contributors ; 2) discontinuous permafrost is surficial deposits and flat bedrock : - thermal monitoring is performed on five rockglacier sites and includes ground surface temperature (GST) and annual BTS campaigns on some sites. Two medium depth boreholes (15 m) have been made in 2009 on one site, and equipped for thermal profile monitoring. A deep borehole (100 m) will be made in 2010 at 45° N latitude ; - geophysical monitoring is performed on 4 sites : repeated vertical electrical soundings exist for some sites since 20 years, and have been complemented since 2007 by eletrical resistivity tomography (ERT) and refraction seismics ; - surficial displacements of rockglaciers : surficial displacements are measured either by classical geodesy or by DGPS on 6 rockglaciers ; 3) sporadic permafrost at middle altitudes : - an inventory of cold scree slopes and biological investigations on soil and tree growth (dendrogeomorphology) have already been achieved ; - a thermal monitoring should be initiated on selected sites in 2010 ; 4) seasonal frost and frost/thaw cycles at middle and low

  19. Coincidences among Mont Blanc, Kamiokande, Baksan, IMB, Frejus, Homestake and Plateau Rosa detectors during SN1987A.

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.; Fulgione, W.; Galeotti, P.; Saavedra, O.; Trinchero, G.; Vernetto, S.

    Correlation analysis has been performed among the events recorded during the occurrence of SN1987A by the underground detectors of Mont Blanc, Kamiokande, Baksan, IMB, Frejus, Homestake and the EAS array of Plateau Rosa. A significative excess of coincidence exists between low energy events of Mont Blanc and IMB muons, in the time interval from 1:45 to 3:45 UT on Feb. 23, 1987.

  20. An event observed by the Mont Blanc underground neutrino detector on February 23, 1987

    NASA Astrophysics Data System (ADS)

    Dadykin, V. L.; Zatsepin, G. T.; Korchaguin, V. B.; Korchaguin, P. V.; Malgin, A. S.; Ryazhskaya, O. G.; Ryassny, V. G.; Talochkin, V. P.; Khalchukov, F. F.; Yakushev, V. F.; Aglietta, M.; Badino, G.; Bologna, G.; Vernetto, S.; Galeotti, P.; Castagnoli, C.; Castellina, A.; Saavedra, O.; Trinchero, G.; Fulgione, W.

    1988-02-01

    An analysis is made of the event detected by the Soviet-Italian neutrino scintillation detector (LSD) beneath Mont Blanc on Februrary 23, 1987 at 2:52:37 UT. Corrected energies of the pulses of the event have been determined along with the probability of event imitiation by the background. The LSD data are compared with Kamiokande and IMB data. The possibility that the observed event may be connected with the explosion of SN 1987A is examined.

  1. The research program of the Liquid Scintillation Detector (LSD) in the Mont Blanc Laboratory

    NASA Technical Reports Server (NTRS)

    Dadykin, V. L.; Yakushev, V. F.; Korchagin, P. V.; Korchagin, V. B.; Malgin, A. S.; Ryassny, F. G.; Ryazhskaya, O. G.; Talochkin, V. P.; Zatsepin, G. T.; Badino, G.

    1985-01-01

    A massive (90 tons) liquid scintillation detector (LSD) has been running since October 1984 in the Mont Blanc Laboratory at a depth of 5,200 hg/sq cm of standard rock. The research program of the experiment covers a variety of topics in particle physics and astrophysics. The performance of the detector, the main fields of research are presented and the preliminary results are discussed.

  2. Drug Use on Mont Blanc: A Study Using Automated Urine Collection.

    PubMed

    Robach, Paul; Trebes, Gilles; Lasne, Françoise; Buisson, Corinne; Méchin, Nathalie; Mazzarino, Monica; de la Torre, Xavier; Roustit, Matthieu; Kérivel, Patricia; Botré, Francesco; Bouzat, Pierre

    2016-01-01

    Mont Blanc, the summit of Western Europe, is a popular but demanding high-altitude ascent. Drug use is thought to be widespread among climbers attempting this summit, not only to prevent altitude illnesses, but also to boost physical and/or psychological capacities. This practice may be unsafe in this remote alpine environment. However, robust data on medication during the ascent of Mont Blanc are lacking. Individual urine samples from male climbers using urinals in mountain refuges on access routes to Mont Blanc (Goûter and Cosmiques mountain huts) were blindly and anonymously collected using a hidden automatic sampler. Urine samples were screened for a wide range of drugs, including diuretics, glucocorticoids, stimulants, hypnotics and phosphodiesterase 5 (PDE-5) inhibitors. Out of 430 samples analyzed from both huts, 35.8% contained at least one drug. Diuretics (22.7%) and hypnotics (12.9%) were the most frequently detected drugs, while glucocorticoids (3.5%) and stimulants (3.1%) were less commonly detected. None of the samples contained PDE-5 inhibitors. Two substances were predominant: the diuretic acetazolamide (20.6%) and the hypnotic zolpidem (8.4%). Thirty three samples were found positive for at least two substances, the most frequent combination being acetazolamide and a hypnotic (2.1%). Based on a novel sampling technique, we demonstrate that about one third of the urine samples collected from a random sample of male climbers contained one or several drugs, suggesting frequent drug use amongst climbers ascending Mont Blanc. Our data suggest that medication primarily aims at mitigating the symptoms of altitude illnesses, rather than enhancing performance. In this hazardous environment, the relatively high prevalence of hypnotics must be highlighted, since these molecules may alter vigilance.

  3. Drug Use on Mont Blanc: A Study Using Automated Urine Collection

    PubMed Central

    Robach, Paul; Trebes, Gilles; Lasne, Françoise; Buisson, Corinne; Méchin, Nathalie; Mazzarino, Monica; de la Torre, Xavier; Roustit, Matthieu; Kérivel, Patricia; Botré, Francesco; Bouzat, Pierre

    2016-01-01

    Mont Blanc, the summit of Western Europe, is a popular but demanding high-altitude ascent. Drug use is thought to be widespread among climbers attempting this summit, not only to prevent altitude illnesses, but also to boost physical and/or psychological capacities. This practice may be unsafe in this remote alpine environment. However, robust data on medication during the ascent of Mont Blanc are lacking. Individual urine samples from male climbers using urinals in mountain refuges on access routes to Mont Blanc (Goûter and Cosmiques mountain huts) were blindly and anonymously collected using a hidden automatic sampler. Urine samples were screened for a wide range of drugs, including diuretics, glucocorticoids, stimulants, hypnotics and phosphodiesterase 5 (PDE-5) inhibitors. Out of 430 samples analyzed from both huts, 35.8% contained at least one drug. Diuretics (22.7%) and hypnotics (12.9%) were the most frequently detected drugs, while glucocorticoids (3.5%) and stimulants (3.1%) were less commonly detected. None of the samples contained PDE-5 inhibitors. Two substances were predominant: the diuretic acetazolamide (20.6%) and the hypnotic zolpidem (8.4%). Thirty three samples were found positive for at least two substances, the most frequent combination being acetazolamide and a hypnotic (2.1%). Based on a novel sampling technique, we demonstrate that about one third of the urine samples collected from a random sample of male climbers contained one or several drugs, suggesting frequent drug use amongst climbers ascending Mont Blanc. Our data suggest that medication primarily aims at mitigating the symptoms of altitude illnesses, rather than enhancing performance. In this hazardous environment, the relatively high prevalence of hypnotics must be highlighted, since these molecules may alter vigilance. PMID:27253728

  4. Analysis of the data recorded by the Mont Blanc neutrino detector andby the Maryland and Rome gravitational wave detectors during SN1987A.

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Amaldi, E.; Badino, G.; Bassan, M.; Bologna, G.; Bonifazi, P.; Castagnoli, C.; Castellano, M. G.; Castellina, A.; Coccia, E.; Cosmelli, C.; Dadykin, V. L.; Frasca, S.; Fulgione, W.; Galeotti, P.; Gretz, D.; Kalchukov, F. F.; Malguin, A. S.; Modena, I.; Pallottino, G. V.; Pizzella, G.; Rapagnani, P.; Ricci, F.; Ryassny, V. G.; Ryazhskaya, O. G.; Saavedra, O.; Trinchero, G.; Vannaroni, G.; Vernetto, S.; Weber, J.; Wilmot, G.; Zatsepin, G. T.

    The data recorded by the gravitational wave and neutrino detectors have been analyzed over a period of 18h that includes the Mont Blanc 5ν burst occurrence time. A correlation is found during a period of about two hours roughly centered on the 5ν burst, independently between Maryland and Mont Blanc and Rome and Mont Blanc. The probability that these two correlations be due to chance is of the order of 3×10-6.

  5. Analysis of the data recorded by the Mont Blanc neutrino detector and by the Maryland and Rome gravitational-wave detectors during SN 1987 A

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.

    1989-02-01

    The paper presents data recorded by the neutrino detector on Mont Blanc and by gravitational wave detectors in Maryland and Rome. The data were obtained over a period of several days and include the occurrence of the Mont Blanc five-neutrino burst. A correlation is found during a period of about two hours roughly centered on the five-neutrino burst, independently between Maryland and Mont Blanc and Rome and Mont Blanc. The probability that these two correlations are due to chance is of the order of between 10 to the -6th and 10 to the -5th.

  6. Coso MT Site Locations

    DOE Data Explorer

    Doug Blankenship

    2011-05-04

    This data includes the locations of the MT data collected in and around the Coso Geothermal field that covered the West Flank area. These are the data that the 3D MT models were created from that were discussed in Phase 1 of the West Flank FORGE project. The projected coordinate system is NAD 1927 State Plane California IV FIPS 0404 and the Projection is Lambert Conformal Conic. Units are in feet.

  7. Power Output during the Tour de France.

    PubMed

    Vogt, S; Schumacher, Y O; Roecker, K; Dickhuth, H-H; Schoberer, U; Schmid, A; Heinrich, L

    2007-09-01

    The aim of this study was to evaluate the demands of riding a "Grand Tour" by monitoring both heart rate and power output in 15 professional cyclists. SRM power output profiles (SRM Trainingsystem, Jülich, Germany) were collected during 148 mass start stages during the 2005 Tour de France and analyzed to establish average power, heart rate (HR) and cadence produced in different terrain categories (flat [FLT]; semi-mountainous [SMT]; mountainous [MT]). The maximal mean power (MMP) for progressively longer durations was quantified. Average HR was similar between FLT (133 +/- 10 bpm) and SMT (134 +/- 8 bpm) but higher during MT (140 +/- 3 bpm). Average power output revealed a similar trend (FLT 218 +/- 21 W [3.1 +/- 0.3 W/kg], SMT 228 +/- 22 W [3.3 +/- 0.3 W/kg], and MT 234 +/- 13 W [3.3 +/- 0.2 W/kg]). Cadence during MT was approximately 6 - 7 rpm lower (81 +/- 15 rpm) compared to FLT or SMT. During MT stages, the MMP for 1800 sec. was highest (394 W vs. 342 W) but the MMP 15 was lower (836 W vs. 895 W) compared to FLT. The data document comprehensively the power output demands during the Tour de France.

  8. ALP-RISK, a smartphone app for collecting data on geomorphic phenomena at high altitude in the Mont Blanc region

    NASA Astrophysics Data System (ADS)

    Ravanel, Ludovic; Deline, Philip

    2014-05-01

    A network of observers (mountain guides, hut keepers and mountaineers) has been created from 2005 for the Mont Blanc massif in order to acquire data on rockfall in permafrost-affected rock walls. This network, fully operational since 2007, is based on observation sheets or oral communications and has documented nearly 350 events with volume between 100 and 45,000 m3. Their analysis confirmed and helped to better understand the role of the permafrost degradation as main triggering factor. To i) reinforce this network, ii) facilitate its observation work and iii) develop it as well in space (the whole Mont Blanc region, or eventually the whole western Alps) as in a thematic point of view (all glacial and periglacial brutal phenomena), the Alp-Risk app has been created in the framework of the Alcotra PrévRisk Mont-Blanc project. The latter (2011-13) has been developed to improve the prevention of individual and collective natural hazards around the Mont Blanc massif. The app was created for I-Phones and Androids in three languages (French, English and Italian) and allows, as intuitively and quickly as possible, transmitting data on natural hazards in high mountain (snow and ice avalanche, landslides and rockfalls, landslides, moraine destabilization, water pocket outburst flood, torrential flood, and others) to both practitioners (observations available directly on the app via an interface web), scientists, and possibly local managers. Alp-Risk thus constitutes a new step for participatory science in the Mont Blanc region.

  9. Constraints from 40Ar/39Ar geochronology on the timing of Alpine shear zones in the Mont Blanc-Aiguilles Rouges region of the European Alps

    NASA Astrophysics Data System (ADS)

    Egli, D.; Mancktelow, N.; Spikings, R.

    2017-04-01

    The Mont Blanc and Aiguilles Rouges massifs, which form part of the external crystalline massifs of the western European Alps, record a young and fast exhumation history, as established by an extensive low-temperature thermochronology and geochronology data set. Various kinematic and dynamic models for Oligocene to Neogene deformation and exhumation of the Aiguilles Rouges-Mont Blanc system have been proposed. However, the timing of deformation along major shear zones in and around the massifs, which is crucial to these models, is still controversial. Our new 40Ar/39Ar data from key deformation zones in the Mont Blanc area show that NW directed thrusting lasted from Oligocene to mid-Miocene times in the Mont Blanc massif before a NW-ward jump of the deformation front to below the Aiguilles Rouges massif, which led to updoming of the Aiguilles Rouges and Mont Blanc massifs. This deactivated the main NW verging shear zones and caused back-folding and back thrusting east of the Mont Blanc, as well as upward extrusion of the Aiguilles Rouges massif. Subsequently, there was a switch to more coaxial shortening between the Aiguilles Rouges and Mont Blanc massifs associated with strain partitioning and related dextral strike-slip deformation on the eastern side of the Mont Blanc massif.

  10. Investigating K-feldspar Luminescence Thermochronometry for Application in the Mont Blanc Massif

    NASA Astrophysics Data System (ADS)

    Lambert, R.; King, G. E.; Herman, F.; Valla, P.

    2015-12-01

    Luminescence dating has the potential to quantify the recent exhumation history of mountain ranges as a low-temperature thermochronometer. During rock exhumation, electrons get trapped through exposure to ionizing radiation whilst elevated temperatures cause thermally stimulated detrapping. The resulting luminescence signals measured in the laboratory can be used to constrain rock thermal histories through modelling of the kinetic parameters of electron trapping and detrapping. Here, we investigate and model laboratory kinetic processes of the luminescence of K-feldspar and assess their extrapolation over geological timescales. Samples were taken from the actively eroding Mont Blanc massif in the European Alps, along a 12 km long tunnel with ambient temperatures of 10-35 °C. In this setting rapid exhumation rates have been found during the last 2 million years (up to ~2 km/Myr), however, we intend to increase the temporal resolution to sub-Quaternary timescales using luminescence thermochronometry. Infra-red stimulated luminescence signals at 50 °C (IR50) and at 225 °C (post-IR IRSL225) of K-feldspar extracted from Mont Blanc tunnel samples were measured and our first results reveal a thermal signature from which rock cooling rates can be derived. Isothermal decay experiments show non-exponential decay, but interestingly, experiments with a range of regenerative doses reveal first-order kinetics. The observed thermal decay pattern is well-described by a model based on a physically plausible distribution of the density of states. Ultimately, we intend to use the IR50 and post-IR IRSL225 signals of K-feldspar as dual thermochronometers to determine the late-Quaternary cooling history of the Mont Blanc massif. Moreover, the luminescence signals may give insights into local thermal field evolution, before the influence of postglacial hydrothermal flow.

  11. Correlation analysis of the data recorded by the Baksan, Kamioka, and Mont Blanc detectors during SN 1987A

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.

    1989-12-01

    Results are presented on the correlation analysis of data recorded by the Baksan, Kamioka, and Mont Blanc underground detectors during the explosion of the SN 1987. The analysis was performed in order to reinvestigate the observations of two burst of several pulses each occurring several hours before first optical observations. The Mont Blanc computer detected a burst of five pulses about 8 hrs before the first optical observation, followed by a second burst of three pulses about 2 hrs later; Kamioka and Baksan reported observations of a burst made by eleven and five pulses, respectively, delayed by 4.7 hrs in comparison with the Mont Blanc burst. The results of the analysis strongly suggest that the event was real, occurring a few hours before the first optical observation of SN 1987A.

  12. Search for fractionally charged particles in the Mont Blanc LSD scintillation detector

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Antonioli, P.; Badino, G.; Castagnoli, C.; Castellina, A.; Dadykin, V. L.; Fulgione, W.; Galeotti, P.; Khalchukov, F. F.; Korolkova, E. V.; Kortchaguin, P. V.; Kortchaguin, V. B.; Kudryavtsev, V. A.; Malguin, A. S.; Marchetti, G.; Periale, L.; Ryassny, V. G.; Ryazhskaya, O. G.; Saavedra, O.; Trinchero, G. C.; Vernetto, S.; Yakushev, V. F.; Zatsepin, G. T.

    1994-02-01

    An analysis of the events recorded by the Mont Blanc Neutrino Scintillation Detector was performed in order to search for fractionally charged particles with |Q| = 1/3and |Q| = 2/3. In a live time of 2378 days, the obtained 90% C. L. upper limits on the fluxes of fractionally charged particles in the core of our detector are Φ(|Q| = 1/3) < 2. 3 10 -13cm-2s-1sr-1and Φ(|Q| = 2/3) < 2. 7 10 -13cm-2s-1sr-1, the best available limits obtained by scintillation counters technique.

  13. Neutrino out-blow from supernova 1987A detected in the Mont Blanc observatory

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.

    The authors discuss the neutrino outflow connected with the event detected in the Mont Blanc Underground Neutrino Observatory on February 23, 1987, and consisting of 5 interactions recorded during 7 seconds. The measured energies of the 5 pulses, the duration of the burst, and the advance of the detection time in comparison with the first optical observations give evidence that the event can be explained in terms of detection of neutrinos emitted during the stellar collapse in the Large Magellanic Cloud, which originated supernova SN 1987A.

  14. Schatten Matrix Norm Based Polarimetric SAR Data Regularization Application over Chamonix Mont-Blanc

    NASA Astrophysics Data System (ADS)

    Le, Thu Trang; Atto, Abdourrahmane M.; Trouve, Emmanuel

    2013-08-01

    The paper addresses the filtering of Polarimetry Synthetic Aperture Radar (PolSAR) images. The filtering strategy is based on a regularizing cost function associated with matrix norms called the Schatten p-norms. These norms apply on matrix singular values. The proposed approach is illustrated upon scattering and coherency matrices on RADARSAT-2 PolSAR images over the Chamonix Mont-Blanc site. Several p values of Schatten p-norms are surveyed and their capabilities on filtering PolSAR images is provided in comparison with conventional strategies for filtering PolSAR data.

  15. Present-day subglacial erosion efficiency inferred from sources and transport of glacial clasts in the North face of Mont Blanc

    NASA Astrophysics Data System (ADS)

    Mugnier, J. L.; Godon, C.; Buoncristiani, J. F.; Paquette, J. L.; Trouvé, E.

    2012-04-01

    The efficiency of erosional processes is classically considered from detrital composition at the outlet of a shed that reflects the rocks eroded within the shed. We adapt fluvial detrital thermochronology (DeCelles et al., 2004) and lithology (Attal and Lavé, 2006) methods to the subglacial streams of the north face of the Mont Blanc. The lithology of this area is composed by a ~303 Ma old granite intruded within an older poly metamorphic complex (orthogneisses). In this study,we use macroscopic criteria (~10 000 clasts) and Ur/Pb dating of zircons (~500 datings of sand grains) to determine the provenance of the sediment transported by the glacier and by the sub-glacial streams. Samples come from sediments collected around the glacier (above, below or laterally), from different bedrocks sources according to the surface flow lines and glacier characteristics (above or below the ELA; temperate or cold), and from different subglacial streams. A comparison between the proportion of granite and orthogneisses in these samples indicates that: 1) the supra load follows the flow lines of the glacier deduced from SAR images correlation and the displacement pattern excludes supra load mixing of the different sources; 2) the transport by the glacier does not mix the clasts issued from the sub-glacial erosion with the clasts issued from supraglacial deposition, except in the lower tongue where supraglacial streams and moulins move the supraglacial load from top to bottom; 3) the erosion rate beneath the glacier is very small: null beneath the cold ice but also very weak beneath the greatest part of the temperate glacier; the erosion increases significantly beneath the tongue, where supraglacial load incorporated at the base favors abrasion; 4) the glacial erosion rate beneath the tongue remains at least five time smaller than the erosion rate coming from non-glacial area. According to our results, we demonstrate that the glaciers of the Mont-Blanc north face protect the top of

  16. Italy: Mt. Etna

    Atmospheric Science Data Center

    2013-04-17

    ... SpectroRadiometer (MISR) images from Terra orbit 8476 capture the July 22, 2001 explosion of the Mt. Etna volcano. Etna is located ... also expels gases such as water vapor, sulfur dioxide, and carbon dioxide. Although the Etna volcano is one of the world's most ...

  17. Return to Mt. Makiling

    ERIC Educational Resources Information Center

    Wilson, George C.

    1977-01-01

    The National Arts Center of the Philippines, built to assist in the cultural enrichment of the Philippines through the development of young talents, stands today as the Filipino's tribute to the artist. The author discusses his return to Mt. Makiling comparing the development of the National Arts Center with his first visit in October 1973 at the…

  18. Mt. St. Helens Memories.

    ERIC Educational Resources Information Center

    Sharp, Len

    1992-01-01

    Provides a personal account of one science teacher's participation in a teacher workshop in which teachers learned about volcanic development, types of eruption, geomorphology, plate tectonics, volcano monitoring, and hazards created by volcanoes by examining Mt. St. Helens. Provides a graphic identifying volcanoes active since 1975. (MDH)

  19. Mt. St. Helens Memories.

    ERIC Educational Resources Information Center

    Sharp, Len

    1992-01-01

    Provides a personal account of one science teacher's participation in a teacher workshop in which teachers learned about volcanic development, types of eruption, geomorphology, plate tectonics, volcano monitoring, and hazards created by volcanoes by examining Mt. St. Helens. Provides a graphic identifying volcanoes active since 1975. (MDH)

  20. A re-analysis of 533 rockfalls occurred since 2003 in the Mont Blanc massif for the study of their relationship with permafrost

    NASA Astrophysics Data System (ADS)

    Ravanel, Ludovic; Magnin, Florence; Deline, Philip

    2015-04-01

    Rockfall is one of the main natural hazards in high mountain regions and its frequency is growing, especially since two decades. Collapses at high elevation are with an increasing certainty assumed to be a consequence of the climate change through the warming permafrost. In the Mont Blanc massif, data on present rockfalls (occurrence time when possible, accurate location, topographical and geological settings, volume, weather and snow conditions) were acquired for 2003 and for the period 2007-2014 thanks to a satellite image of the massif and a network of observers in the central part of the massif, respectively. The study of the 533 so-documented rockfalls shows a strong correlation at the year scale between air temperature and rockfall. Along with this data acquisition, a statistical model of the Mean Annual Rock Surface Temperature (MARST) for the 1961-1990 period has been implemented on a 4-m-resolution DEM of the Mont Blanc massif. The model runs with Potential Incoming Solar radiation (PISR) calculated with GIS tools and air temperature parameters computed from Chamonix Météo France records. We cross here the data on rockfalls with the permafrost distribution model to show that: (i) rockfall occurs mainly over modeled negative MARST (context of permafrost); (ii) simulated warm permafrost areas (> -2°C) are the most affected by instabilities; (iii) as the 1961-1990 period is supposed to be representative of the conditions at depth that are not affected by the climate warming during the two last decades, the latest results are mainly valuable for rockfalls related to pluri-decadal signal; and (iv) the higher (close to 0°C) the MARST, the deeper the detachment (possibly related to the deepening of the permafrost active layer). These results and field observations confirm that warming permafrost corresponds to the main required configuration for rockfall triggering at high elevation. In addition, we show that rockfalls for which ice observed in their scar

  1. Influence of juice pressing conditions on polyphenols, antioxidants, and varietal aroma of Sauvignon blanc microferments.

    PubMed

    Patel, Parimal; Herbst-Johnstone, Mandy; Lee, Soon A; Gardner, Richard C; Weaver, Randy; Nicolau, Laura; Kilmartin, Paul A

    2010-06-23

    The impact of juice press fractions upon the content of varietal thiols in Sauvignon blanc has been examined for wines fermented at the laboratory scale (750 mL). Wines made from pressed juices (taken at 0.25 and 1.0 bar) contained less than half the concentration of 3-mercaptohexan-1-ol (3MH) and 3-mercaptohexyl acetate (3MHA), important contributors to the tropical and passion fruit character of Sauvignon blanc wines, compared to wines made from free run juices. The pressed juices and wines exhibited lower acidity values, more rapid decline in glutathione content, and more advanced polyphenol oxidation. Supplementation of the juices with glutathione (at 67 mg/L) prior to fermentation led to lower varietal thiol concentrations in the finished wines, typically by several percent, whereas treatment with polyvinylpolypyrrolidone (PVPP) made no impact on wine parameters. Pasteurization of pressed juices increased 3MHA content in the finished wines, but also led to a decline in 3MH concentrations.

  2. Influence of fermentation temperature on volatile thiols concentrations in Sauvignon blanc wines.

    PubMed

    Masneuf-Pomarède, Isabelle; Mansour, Chantal; Murat, Marie-Laure; Tominaga, Takatoshi; Dubourdieu, Denis

    2006-05-01

    The effect of Saccharomyces cerevisiae strains on the amount of 4-mercapto-4-methylpentan-2-one, a major varietal aroma of Sauvignon blanc wines, was demonstrated by previous research work. However, the influence of different alcoholic fermentation parameters on the levels of volatile thiols (4-mercapto-4-methylpentan-2-one, 3-mercaptohexan-1-ol and 3-mercaptohexyl acetate) in wines has not yet been investigated. The impact of fermentation temperature on the final amount of volatiles thiols and on some other analytical parameters (ethanol, total acidity, residual sugars, volatile acidity) was determined in a model medium and in grape juice. Interaction between fermentation temperature and yeast strain was also tested. The fermentation temperature influenced the amount of volatile thiols irrespective of the yeast strain used. The final levels of 4MMP and 3MH in model medium and in wines were higher when the alcoholic fermentation is conducted at 20 degrees C than at 13 degrees C. The 3MHA, which was correlated with the amount of 3MH determined in wines, was also higher when the alcoholic fermentation was conducted at 20 degrees C. From a technological point of view, the choice of yeast strain and fermentation temperature has a decisive influence on the concentrations of the varietal aromas of Sauvignon blanc wines.

  3. New radiocarbon chronology of a late Holocene landslide event in the Mont Blanc massif, Italy

    NASA Astrophysics Data System (ADS)

    Hajdas, Irka; Sojc, Ursula; Ivy-Ochs, Susan; Akçar, Naki; Deline, Philip

    2016-04-01

    The Ferret valley Arp Nouva peat bog located in the Mont Blanc massif was critically evaluated since previously published radiocarbon dates have led to controversial conclusions on the formation of the swamp. Radiocarbon dating of roots from three pits of up to 1 m depth was applied to discuss the question whether the historical documented rock avalanche occurring in AD 1717 overran the peat bog or formed it at a later stage. Our results indicate that the rock avalanche formed the Arp Nouva peat bog by downstream blockage of the Bellecombe torrent. Furthermore, careful sample preparation with consequent separation of roots from the bulk peat sample provides possible explanation for the too old 14C ages of bulk peat samples dated previously (Deline and Kirkbride, 2009 and references therein). This work demonstrates that a combined geomorphological and geochronological approach is the most reliable way to reconstruct landscape evolution, especially in light of apparent chronological problems. The key to successful 14C dating is a careful sample selection and the identification of material that might be not ideal for chronological reconstructions. References Deline, Philip, and Martin P. Kirkbride. "Rock avalanches on a glacier and morainic complex in Haut Val Ferret (Mont Blanc Massif, Italy)".Geomorphology 103 (2009): 80-92.

  4. Mineralogy and ore fluid chemistry of the Roc Blanc Ag deposit, Jebilet Hercynian massif, Morocco

    NASA Astrophysics Data System (ADS)

    Essarraj, Samira; Boiron, Marie-Christine; Cathelineau, Michel; Tarantola, Alexandre; Leisen, Mathieu; Hibti, Mohamed

    2017-03-01

    The Roc Blanc Ag deposit is located about 20 km north of Marrakesh city (Morocco) in the Jebilet Hercynian massif. The ore bodies consist of N-S to NE-SW quartz (±carbonates) veins hosted by the Sarhlef marine sediments. These series, deposited in a Devonian-Carboniferous rift basin context, were deformed during the Hercynian orogeny, and submitted to low-grade regional metamorphism. Two major stages of fluid circulation and metal deposition are distinguished on the basis of mineralogical and paleo-fluid studies carried out on quartz and dolomite (microthermometry, Raman spectroscopy, LA-ICP-MS on individual inclusions, and O, H stable isotope data): (i) an early Fe-As stage, characterized by the circulation of metamorphic aqueous-carbonic fluids, under P-T conditions lower than 200 MPa ± 20 MPa and 400 °C respectively, along N-S structures; (ii) the ore stage, characterized by the circulation of a Na-Mg-K ± Ca high salinity brine, poor in gas but rich in metals such as Fe, Sr, Ba, Zn, Pb, ± Cu (salinity ranging from 19.6 wt% to likely more than 30 wt% NaCl equiv.) and the deposition of a sphalerite/dolomite-calcite assemblage; such a fluid likely evolved to a Na-K-(Ca-Mg)-Ag brine, with significant Pb and Sb concentrations and lower Sr, Ba and Zn concentrations than in the preceding fluid (salinity up to 19.4 wt% NaCl equiv.). The Ag content of the second mineralizing brine ranges from 0.9 mmol/kg to 9.4 mmol/kg solution (100 ppm-1000 ppm), whereas the base metal brine is generally Ag poor (up to 1.3 mmol/kg solution: 140 ppm). Dilution of the Ag brine by low salinity fluids (<6 wt% NaCl equiv., and Th from 130° to 230 °C) seems to be the main driving mechanism for the Ag ore deposition at Roc Blanc, with a possible involvement of cooling and reduction reactions in black schists. Base metal and Ag fluids may have circulated at average temperatures around 200 ± 30 °C or slightly higher and under hydrostatic pressures, along dominant E-W structures. The ore

  5. Electron drift velocities in mixtures of helium and xenon and experimental verification of corrections to Blanc's law

    SciTech Connect

    Sasic, O.; Jovanovic, J.; Petrovic, Z. Lj.; Urquijo, J. de; Castrejon-Pita, J.R.; Hernandez-Avila, J.L.; Basurto, E.

    2005-04-01

    Measurements of electron drift velocities were performed in pure Xe and He and in a number of mixtures ranging up to 70% of Xe. The data were obtained by using a pulsed Townsend technique over the density-normalized electric field strength E/N between 1 and 100 Td. Even for pure gases there are no data in the entire range covered here, and these data represent an extension of accurate drift velocities to higher E/N. A selection of well-established cross sections for low energies, which was extended to higher energies, led to a reasonably good agreement of the calculated transport coefficients with the available data. At the same time we have applied the standard (common E/N) Blanc's law and two forms of common mean energy (CME, due to Chiflykian) procedures. Blanc's law fails for most mixtures at low and moderate E/N, while the CME procedure is capable of following the experimental data for the mixtures much more closely, and even predicting the negative differential conductivity region when such effect does not exist for pure gases. Thus the present paper also represents an experimental test of procedures to correct the standard Blanc's law. Finally, we have used the data for two mixtures to obtain results for the third mixture and in all cases this procedure gave excellent results even though only the standard Blanc's law was used in the process.

  6. Mt. Etna, Italy

    NASA Image and Video Library

    2002-11-07

    On Sunday, November 3, 2002, Mt. Etna's ash-laden plume was imaged by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. The plume is seen blowing toward the south-southeast, over the city and airport of Catania, Sicily. The previous day, the plume was blowing toward the northwest, and posed no hazard to Catania. The current eruption of Mt. Etna, Europe's most active volcano, began on October 27. These sorts of observations from space may help civil defense authorities mitigate hazards from active eruptions. Space data may also help scientists evaluate the behavior and effects volcanic eruptions have on our global climate system. http://photojournal.jpl.nasa.gov/catalog/PIA03881

  7. Mt. Spurr's 1992 eruptions

    USGS Publications Warehouse

    1993-01-01

    On 27 June, 1992, the Crater Peak vent on the south side of Mt. Spurr awoke from 39 years of dormancy and burst into sub-plinian eruption after 10 months of elevated seismicity. Two more eruptions followed in August and September. The volcano lies 125 km west of Anchorage, Alaska's largest city and an important international hub for air travel. The Alaska Volcano Observatory (AVO) was able to warn communities and the aviation industry well in advance of these eruptions.

  8. Thermal conditions of rock slopes below unstable infrastructure in Alpine permafrost area: the cases of the Cosmiques hut and the Grands Montets cable-car station (Mont Blanc massif)

    NASA Astrophysics Data System (ADS)

    Duvillard, Pierre-Allain; Magnin, Florence; Mörtl, Christian; Ravanel, Ludovic; Deline, Philip

    2017-04-01

    rock ridge: the lower arête des Cosmiques, Mont-Blanc massif, France. Geografiska Annaler A, 95 : 51-66.

  9. Pre-fermentation fining effects on the aroma chemistry of Marlborough Sauvignon blanc press fractions.

    PubMed

    Parish, Katie J; Herbst-Johnstone, Mandy; Bouda, Flo; Klaere, Steffen; Fedrizzi, Bruno

    2016-10-01

    In the wine industry, fining agents are commonly used with many choices now commercially available. Here the influence of pre-fermentation fining on wine aroma chemistry has been explored. Free run and press fraction Sauvignon blanc juices from two vineyards were fined using gelatin, activated carbon, polyvinylpolypyrrolidone (PVPP) and a combination agent which included bentonite, PVPP and isinglass. Over thirty aroma compounds were quantified in the experimental wines. Results showed that activated carbon fining led to a significant (p<0.05) concentration decrease of hexan-1-ol and linalool in the experimental wines when compared to a control, consistent across all vineyard and fraction combinations. Other aroma compounds were also influenced by fining agent, even if vineyards and press fractions played a crucial role. This study confirmed that fining agents used pre-fermentation can influence wine aroma profiles and therefore needs specific tailoring addressing style and origin of grape. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Pinot blanc and Pinot gris arose as independent somatic mutations of Pinot noir

    PubMed Central

    Vezzulli, Silvia

    2012-01-01

    Somatic mutation is a natural mechanism which allows plant growers to develop new cultivars. As a source of variation within a uniform genetic background, it also represents an ideal tool for studying the genetic make-up of important traits and for establishing gene functions. Layer-specific molecular characterization of the Pinot family of grape cultivars was conducted to provide an evolutionary explanation for the somatic mutations that have affected the locus of berry colour. Through the study of the structural dynamics along chromosome 2, a very large deletion present in a single Pinot gris cell layer was identified and characterized. This mutation reveals that Pinot gris and Pinot blanc arose independently from the ancestral Pinot noir, suggesting a novel parallel evolutionary model. This proposed ‘Pinot-model’ represents a breakthrough towards the full understanding of the mechanisms behind the formation of white, grey, red, and pink grape cultivars, and eventually of their specific enological aptitude. PMID:23095995

  11. Limits on low-energy neutrino fluxes with the Mont Blanc liquid scintillator detector

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Antonioli, P.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.; Dadykin, V. L.; Fulgione, W.; Galeotti, P.; Khalchukov, F. F.; Korolkova, E. V.; Kortchaguin, P. V.; Kortchaguin, V. B.; Kudryavtsev, V. A.; Malguin, A. S.; Periale, L.; Ryassny, V. G.; Ryazhskaya, O. G.; Saavedra, O.; Trinchero, G.; Vernetto, S.; Yakushev, V. F.; Zatsepin, G. T.

    1992-11-01

    The LSD liquid scintillation detector has been operating since 1985 as an underground neutrino observatory in the Mont Blanc Laboratory with the main objective of detecting antineutrino bursts from collapsing stars. In August 1988 the construction of an additional lead and borex paraffin shield considerably reduced the radioactive background and increased the sensitivity of the apparatus. In this way the search for steady fluxes of low-energy neutrinos of different flavours through their interactions with free protons and carbon nuclei of the scintillator was made possible. No evidence for a galactic collapse was observed during the whole period of measurement. The corresponding 90% c.l. upper limit on the galactic collapses rate is 0.45 y -1 for a burst duration of ΔT ⩽ 10 s. After analysing the last 3 years data, the following 90% c.l. upper limits on the steady neutrino and antineutrino fluxes were obtained:

  12. Orsay, Santeuil and Le Blanc viruses primarily infect intestinal cells in Caenorhabditis nematodes.

    PubMed

    Franz, Carl J; Renshaw, Hilary; Frezal, Lise; Jiang, Yanfang; Félix, Marie-Anne; Wang, David

    2014-01-05

    The discoveries of Orsay, Santeuil and Le Blanc viruses, three viruses infecting either Caenorhabditis elegans or its relative Caenorhabditis briggsae, enable the study of virus-host interactions using natural pathogens of these two well-established model organisms. We characterized the tissue tropism of infection in Caenorhabditis nematodes by these viruses. Using immunofluorescence assays targeting proteins from each of the viruses, and in situ hybridization, we demonstrate viral proteins and RNAs localize to intestinal cells in larval stage Caenorhabditis nematodes. Viral proteins were detected in one to six of the 20 intestinal cells present in Caenorhabditis nematodes. In Orsay virus-infected C. elegans, viral proteins were detected as early as 6h post-infection. The RNA-dependent RNA polymerase and capsid proteins of Orsay virus exhibited different subcellular localization patterns. Collectively, these observations provide the first experimental insights into viral protein expression in any nematode host, and broaden our understanding of viral infection in Caenorhabditis nematodes.

  13. Grape cluster microclimate influences the aroma composition of Sauvignon blanc wine.

    PubMed

    Martin, Damian; Grose, Claire; Fedrizzi, Bruno; Stuart, Lily; Albright, Abby; McLachlan, Andrew

    2016-11-01

    New Zealand Sauvignon blanc (SB) wines are characterised by a distinctive combination of tropical-fruity and green-herbaceous aromatic compounds. The influence of sunlight exposure of grape clusters on juice and wine composition was investigated, with the aim of manipulating aromatic compounds in SB wine. In the absence of basal leaf removal SB clusters naturally exposed to sunlight were riper than shaded clusters, evidenced by higher total soluble solids (TSS) and proline, and lower malic acid, 3-isobutyl-2-methoxypyrazine (IBMP) and arginine. Volatile thiols in wines did not differ between shaded and exposed clusters. At equivalent TSS, cluster exposure had little or no effect on malic acid concentration. Conversely, wine from shaded clusters had almost double the IBMP concentration of wine from exposed clusters at equivalent TSS. The effects on SB juice and wine composition of natural variations in cluster microclimate are not comparable with the effects of cluster exposure created through leaf removal.

  14. Rock avalanches on a glacier and morainic complex in Haut Val Ferret (Mont Blanc Massif, Italy)

    NASA Astrophysics Data System (ADS)

    Deline, Philip; Kirkbride, Martin P.

    2009-01-01

    Deposits in upper Val Ferret (Mont Blanc Massif, Italy) have been attributed to glacier advances and to a rock avalanche of 12 September AD 1717. We review evidence for the timing and mode of emplacement of the deposit, and present a new geomorphic interpretation and relative and absolute dating to show that the AD 1717 deposit is less extensive than previously thought. The landslide was deflected along one side of the valley floor, preserving older slope and morainic sediments along the other side. An earlier rock avalanche onto the Triolet Glacier occurred before AD 1000. The deposits of these landslides partly cover older moraine several kilometres downstream from the present glacier front, and have affected the glacier regimen and construction of its moraines. This study highlights the geomorphic impact of rock avalanches in glacierized high mountains.

  15. [Hemiplegia and a hiking tour of Mont Blanc: from hope to reality].

    PubMed

    Calmels, P; Degache, F; Fayolle-Minon, I; Condemine, A; Courbon, A; Ramas, J; Richard, R; Roche, F; Degache, A; Girardin, N; Gautheron, V; Devillard, X

    2005-05-01

    At the end of an endurance training program for stroke patients with hemiplegia, we offered a hiking tour around the Mont Blanc Pedestrian Tour. We found no publication describing a similar experience and no scientific data in the literature to determine the physiological characteristics required for this performance, particularly regarding cardiac and vascular capacities, level of impairment, and functional abilities. To complete a part of the Mont Blanc Pedestrian Tour over six days, with a group of adults with hemiparesis and aphasia due to stroke. Seven of 20 subjects with right hemiparesis and aphasia were selected on the basis of results of physiological tests, after an endurance training program and two tests hikes at medium altitude. Mean age was 51.71 +/- 7.13 years, mean VO(2max) 19.76 +/- 3.46 ml.g(-1).mm(-1), mean P(max) 90 +/- 22.68 and mean walking speed 3.60 +/- 1.30 km/hour. Organization involved setting up the itinerary, recruiting accompanying personnel (9 people), and arranging security. No specific adaptations for accessibility were available, and no specific equipment was used, except for standard walking sticks. During this pedestrian tour, the subjects demonstrated strong motivation, as well as exceptional physical and functional performance, despite significant changes in elevation (up to 1500 m per day) and long walking times (from 5 to 9 hours per day). This experience has enriched our reflection about the medical, functional, and psychological conditions required for this type of physical effort, both from patients and accompanying personnel. In the absence of reports on similar experiences with this patient population, we thought it interesting, six months after this challenge, to present our observations as well as the patients' point of view. This may encourage other rehabilitation teams to offer intensive walking activities for stroke patients.

  16. The Spirit of France

    DTIC Science & Technology

    1994-01-01

    self - esteem amongst the French, giving France a greater sense of dignity. Charles de Gaulle sought grandeur to unite France and give the people a sense of common purpose. According to de Gaulle, France’s pursuit of its national interests was not narrow and self-serving, but was

  17. Competition in France

    SciTech Connect

    Gipe, P.

    1992-01-01

    This article examines the developing market for windpower in France. The topics discussed in the article include changes in the French energy policy, Electricite de France under pressure to relax absolute control of the electricity market, a new wind energy program involving international wind turbine designs, and public opinion regarding the place of wind power in France.

  18. The use of ground based photogrammetry for the monitoring of seasonal movement of a glacier: the case study of Planpincieux Glacier, Grandes Jorasses massif, Mont Blanc

    NASA Astrophysics Data System (ADS)

    Giordan, Daniele; Dell'Anese, Federico; Allasia, Paolo; Vagliasindi, Marco; Motta, Elena

    2016-04-01

    In September 2013, an experimental low cost monitoring station has been installed on the top of Mt. de La Saxe (Val Ferret, Aosta Valley, NW of Italy) to monitor the Planpincieux Glacier, located on the Italian side of Mont Blanc Massif. This system is based on two commercial APS-C DSLR cameras equipped with a 297 mm and 120 mm optical zoom respectively. Every hour cameras automatically acquire pictures of the lower part of the glacier, which showed to be the most active. The available dataset is analyzed using both change-detection and pixel-offset techniques, to detect the main surface changes over time, as well as to retrieve quantitative measurements of the glacier displacements. The system is able to work throughout the year. The available dataset has been used to analyze the daily evolution of the lower part of the glacier over the May-November period (when the glacier is free from snow) both in 2014 and 2015. The pixel-offset approach allows to measure the displacement of different parts of the glacier and to describe its seasonal evolution. Furthermore, change detection algorithm allows highlighting sudden changes of the scene, usually due to icefalls. The available dataset shows that the displacement rate of the glacier increases during the warm season, that in 2014 it was higher than in 2015, and that it was distributed in a different way. Actually, in 2015, the maximum rate was reached in August, whereas in 2014 the measured summer velocity was lower but it lasted over the months of July, August and September. The results have been validated using different ground based SARs, both in 2014 and 2015. Here we present the results of a three years monitoring, demonstrating the efficiency of pixel-offset and change-detection techniques for contactless monitoring of unreachable glacier surfaces. Furthermore, we present cross-analysis, considering displacements vs. weather measurements, in order to understand glaciers dynamics.

  19. Mt. St. Helens

    NASA Image and Video Library

    2001-10-22

    This 3-D anaglyph image of Mt. St. Helens volcano combines the nadir-looking and back-looking band 3 images of ASTER. To view the image in stereo, you will need blue-red glasses. Make sure to look through the red lens with your left eye. This ASTER image of Mt. St. Helens volcano in Washington was acquired on August 8, 2000 and covers an area of 37 by 51 km. Mount Saint Helens, a volcano in the Cascade Range of southwestern Washington that had been dormant since 1857, began to show signs of renewed activity in early 1980. On 18 May 1980, it erupted with such violence that the top of the mountain was blown off, spewing a cloud of ash and gases that rose to an altitude of 19 kilometers. The blast killed about 60 people and destroyed all life in an area of some 180 square kilometers (some 70 square miles), while a much larger area was covered with ash and debris. It continues to spit forth ash and steam intermittently. As a result of the eruption, the mountain's elevation decreased from 2,950 meters to 2,549 meters. The image is centered at 46.2 degrees north latitude, 122.2 degrees west longitude. http://photojournal.jpl.nasa.gov/catalog/PIA11160

  20. Correlation between background events detected by the Mont Blanc neutrino detector and by the Baksan Neutrino Telescope on 23.02.1987.

    NASA Astrophysics Data System (ADS)

    Alexeyev, E. N.; Alexeyeva, L. N.; Klimenko, N. F.; Kogaj, I. M.; Krivosheina, I. V.; Poddubny, V. A.; Zakidyshev, V. N.

    The Mont Blanc and Baksan neutrino detector data were compared for the period 00:00 - 10:00 UT on 23 February 1987. During one hour (1:45 - 2:45 UT) a correlation between Mont Blanc events, which are mainly caused by natural radioactivity, and Baksan high energy cosmic ray muons has been found. This correlation can probably be associated with SN 1987A.

  1. New structural field data on the timing and kinematics of deformation and exhumation of the Mont Blanc massif

    NASA Astrophysics Data System (ADS)

    Egli, Daniel; Mancktelow, Neil

    2010-05-01

    The Mont Blanc massif is one of the external crystalline massifs, which represent the basement of the former European continental margin and therefore belong to the Helvetic domain. It mainly consists of polymetamorphic Late Proterozoic to Early Paleozoic gneisses intruded by the Variscan Mont Blanc granite (Von Raumer et al. 1993). The timing and kinematics of deformation and exhumation of the Mont Blanc massif is a controversial topic and various models have been proposed. Low-temperature thermochronology studies provide an extensive data set for estimating exhumation rates in Neogene times (e.g. Seward & Mancktelow 1994; Leloup et al. 2005; Glotzbach et al. 2008), but detailed structural studies to critically asses and constrain the proposed kinematic models are largely lacking. Glotzbach et al. (2008) show that the exhumation is episodic, with rates changing from relatively fast (~2.5 km/Ma before 6 Ma) to a slow phase (<0.5 km/Ma between 6 and 3.5 Ma), in turn followed by acceleration to ~1 km/Ma after 3 Ma. Our study presents new structural data from the south-eastern side of the Mont Blanc massif and the adjacent sediments and addresses the tectonic evolution and late stage exhumation history of the massif. The goal is to assess the importance of tectonics versus climate for controlling exhumation, as well as to establish the overall geometry of uplift (2D pop-up, 3D dextral transpressive model, large scale backfolding). A major back-thrust was proposed by previous authors ("Mont Blanc back-thrust", e.g. Leloup et al. 2005, Rolland et al. 2007), characterized as a relatively steeply north-west dipping thrust bringing the Mont Blanc basement back over the tectonostratigraphically higher Helvetic and Ultrahelvetic metasediments. 40Ar¬-39Ar dating of white micas interpreted to have grown during movement on the Mont Blanc back-thrust indicates an initiation of movement around 16 Ma (Rolland et al. 2007). Leloup et al. (2005) suggest a reactivation of this

  2. Mt. Vesuvius, Italy

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This ASTER image of Mt. Vesuvius Italy was acquired September 26, 2000, and covers an area of 36 by 45 km. Vesuvius overlooks the city of Naples and the Bay of Naples in central Italy. In 79 AD, Vesuvius erupted cataclysmically, burying all of the surrounding cites with up to 30 m of ash. The towns of Pompeii and Herculanaeum were rediscovered in the 18th century, and excavated in the 20th century. They provide a snapshot of Roman life from 2000 years ago: perfectly preserved are wooden objects, food items, and the casts of hundreds of victims. Vesuvius is intensively monitored for potential signs of unrest that could signal the beginning of another eruption. The image is centered at 40.8 degrees north latitude, 14.4 degrees east longitude.

    The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  3. Mt. Vesuvius, Italy

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This ASTER image of Mt. Vesuvius Italy was acquired September 26, 2000, and covers an area of 36 by 45 km. Vesuvius overlooks the city of Naples and the Bay of Naples in central Italy. In 79 AD, Vesuvius erupted cataclysmically, burying all of the surrounding cites with up to 30 m of ash. The towns of Pompeii and Herculanaeum were rediscovered in the 18th century, and excavated in the 20th century. They provide a snapshot of Roman life from 2000 years ago: perfectly preserved are wooden objects, food items, and the casts of hundreds of victims. Vesuvius is intensively monitored for potential signs of unrest that could signal the beginning of another eruption. The image is centered at 40.8 degrees north latitude, 14.4 degrees east longitude.

    The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  4. Mt. Vesuvius, Italy

    NASA Image and Video Library

    2001-10-22

    This ASTER image of Mt. Vesuvius Italy was acquired September 26, 2000, and covers an area of 36 by 45 km. Vesuvius overlooks the city of Naples and the Bay of Naples in central Italy. In 79 AD, Vesuvius erupted cataclysmically, burying all of the surrounding cites with up to 30 m of ash. The towns of Pompeii and Herculanaeum were rediscovered in the 18th century, and excavated in the 20th century. They provide a snapshot of Roman life from 2000 years ago: perfectly preserved are wooden objects, food items, and the casts of hundreds of victims. Vesuvius is intensively monitored for potential signs of unrest that could signal the beginning of another eruption. The image is centered at 40.8 degrees north latitude, 14.4 degrees east longitude. http://photojournal.jpl.nasa.gov/catalog/PIA11091

  5. Mt. Kilimanjaro's Receding Glaciers

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Mt. Kilimanjaro (Tanzania), the highest point in all Africa, was photographed by the crew of Space Shuttle mission STS-97 on December 2, 2000 (STS097-701-17). Kilimanjaro (Kilima Njaro or 'shining mountain' in Swahili) is capped by glaciers on its southern and southwestern flanks. The glaciers and snow cap covered a far greater area ten years prior to the view above. Compare the photograph above with a photograph of Kilimanjaro taken in November 1990 by the Space Shuttle mission STS-38 crew. Shuttle photograph provided by the Earth Sciences and Image Analysis Laboratory, Johnson Space Center. Additional photographs taken by astronauts and cosmonauts can be viewed via the NASA - JSC Gateway to Astronaut Photography of Earth.

  6. Mt. St. Helens

    NASA Technical Reports Server (NTRS)

    2001-01-01

    [figure removed for brevity, see original site] [figure removed for brevity, see original site] Figure 1 Movie

    This 3-D anaglyph image of Mt. St. Helens volcano combines the nadir-looking and back-looking band 3 images of ASTER. To view the image in stereo, you will need blue-red glasses. Make sure to look through the red lens with your left eye. Figure 1: This ASTER image of Mt. St. Helens volcano in Washington was acquired on August 8, 2000 and covers an area of 37 by 51 km. Mount Saint Helens, a volcano in the Cascade Range of southwestern Washington that had been dormant since 1857, began to show signs of renewed activity in early 1980. On 18 May 1980, it erupted with such violence that the top of the mountain was blown off, spewing a cloud of ash and gases that rose to an altitude of 19 kilometers. The blast killed about 60 people and destroyed all life in an area of some 180 square kilometers (some 70 square miles), while a much larger area was covered with ash and debris. It continues to spit forth ash and steam intermittently. As a result of the eruption, the mountain's elevation decreased from 2,950 meters to 2,549 meters. The image is centered at 46.2 degrees north latitude, 122.2 degrees west longitude.

    Movie: The simulated fly-over was produced by draping ASTER visible and near infrared image data over a digital topography model, created from ASTER's 3-D stereo bands. The color was computer enhanced to create a natural color image, where the vegetation appears green. The topography has been exaggerated 2 times to enhance the appearance of the relief.

    The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  7. Influence of Fermentation Temperature, Yeast Strain, and Grape Juice on the Aroma Chemistry and Sensory Profile of Sauvignon Blanc Wines.

    PubMed

    Deed, Rebecca C; Fedrizzi, Bruno; Gardner, Richard C

    2017-10-02

    Sauvignon blanc wine, balanced by herbaceous and tropical aromas, is fermented at low temperatures (10-15 °C). Anecdotal accounts from winemakers suggest that cold fermentations produce and retain more "fruity" aroma compounds; nonetheless, studies have not confirmed why low temperatures are optimal for Sauvignon blanc. Thirty-two aroma compounds were quantitated from two Marlborough Sauvignon blanc juices fermented at 12.5 and 25 °C, using Saccharomyces cerevisiae strains EC1118, L-1528, M2, and X5. Fourteen compounds were responsible for driving differences in aroma chemistry. The 12.5 °C-fermented wines had lower 3-mercaptohexan-1-ol (3MH) and higher alcohols but increased fruity acetate esters. However, a sensory panel did not find a significant difference between fruitiness in 75% of wine pairs based on fermentation temperature, in spite of chemical differences. For wine pairs with significant differences (25%), the 25 °C-fermented wines were fruitier than the 12.5 °C-fermented wines, with high fruitiness associated with 3MH. We propose that the benefits of low fermentation temperatures are not derived from increased fruitiness but a better balance between fruitiness and greenness. Even so, since 75% of wines showed no significant difference, higher fermentation temperatures could be utilized without detriment, lowering costs for the wine industry.

  8. Environmental factors controlling the seasonal variability in particle size distribution of modern Saharan dust deposited off Cape Blanc

    NASA Astrophysics Data System (ADS)

    Friese, Carmen A.; van der Does, Michèlle; Merkel, Ute; Iversen, Morten H.; Fischer, Gerhard; Stuut, Jan-Berend W.

    2016-09-01

    The particle sizes of Saharan dust in marine sediment core records have been used frequently as a proxy for trade-wind speed. However, there are still large uncertainties with respect to the seasonality of the particle sizes of deposited Saharan dust off northwestern Africa and the factors influencing this seasonality. We investigated a three-year time-series of grain-size data from two sediment-trap moorings off Cape Blanc, Mauritania and compared them to observed wind-speed and precipitation as well as satellite images. Our results indicate a clear seasonality in the grain-size distributions: during summer the modal grain sizes were generally larger and the sorting was generally less pronounced compared to the winter season. Gravitational settling was the major deposition process during winter. We conclude that the following two mechanisms control the modal grain size of the collected dust during summer: (1) wet deposition causes increased deposition fluxes resulting in coarser modal grain sizes and (2) the development of cold fronts favors the emission and transport of coarse particles off Cape Blanc. Individual dust-storm events throughout the year could be recognized in the traps as anomalously coarse-grained samples. During winter and spring, intense cyclonic dust-storm events in the dust-source region explained the enhanced emission and transport of a larger component of coarse particles off Cape Blanc. The outcome of our study provides important implications for climate modellers and paleo-climatologists.

  9. Mt. Etna, Italy

    NASA Technical Reports Server (NTRS)

    2002-01-01

    On Sunday, November 3, 2002, Mt. Etna's ash-laden plume was imaged by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. The plume is seen blowing toward the south-southeast, over the city and airport of Catania, Sicily. The previous day, the plume was blowing toward the northwest, and posed no hazard to Catania. The current eruption of Mt. Etna, Europe's most active volcano, began on October 27. These sorts of observations from space may help civil defense authorities mitigate hazards from active eruptions. Space data may also help scientists evaluate the behavior and effects volcanic eruptions have on our global climate system.

    With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.

    ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.

    The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.

    Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, Calif., is the U.S. science team leader; Bjorn Eng of JPL is the project manager. The Terra mission is part of NASA's Earth Science

  10. Mt. Etna, Italy

    NASA Technical Reports Server (NTRS)

    2002-01-01

    On Sunday, November 3, 2002, Mt. Etna's ash-laden plume was imaged by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. The plume is seen blowing toward the south-southeast, over the city and airport of Catania, Sicily. The previous day, the plume was blowing toward the northwest, and posed no hazard to Catania. The current eruption of Mt. Etna, Europe's most active volcano, began on October 27. These sorts of observations from space may help civil defense authorities mitigate hazards from active eruptions. Space data may also help scientists evaluate the behavior and effects volcanic eruptions have on our global climate system.

    With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.

    ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.

    The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.

    Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, Calif., is the U.S. science team leader; Bjorn Eng of JPL is the project manager. The Terra mission is part of NASA's Earth Science

  11. Effects of transporting and processing Sauvignon blanc grapes on 3-mercaptohexan-1-ol precursor concentrations.

    PubMed

    Capone, Dimitra L; Jeffery, David W

    2011-05-11

    The effects of different processing treatments on thiol precursor concentrations have been investigated through studies involving transportation of machine-harvested Sauvignon blanc fruit and assessment of different applications of antioxidants, along with juice preparation and enzyme inhibition experiments. The influence these trials had on 3-S-cysteinylhexan-1-ol (Cys-3-MH) and 3-S-glutathionylhexan-1-ol (Glut-3-MH) concentrations in juices is discussed. Very interesting findings included the large increase in precursor concentrations after transportation, particularly for Cys-3-MH, and the limited formation of Glut-3-MH when grape proteins were precipitated during processing. The various results provided information about the ability to modulate precursor concentrations depending on the processing technique employed. Additionally, a conjugated aldehyde, which is the obvious missing link between the reaction of (E)-2-hexenal and glutathione in the formation of Glut-3-MH, has been tentatively identified for the first time. Deuterium-labeled 3-S-glutathionylhexanal (Glut-3-MHAl) was produced through the addition of labeled (E)-2-hexenal to grapes, followed by grape crushing, and detected in the juice by HPLC-MS/MS, along with the corresponding labeled Glut-3-MH.

  12. Inactive dry yeast application on grapes modify Sauvignon Blanc wine aroma.

    PubMed

    Šuklje, Katja; Antalick, Guillaume; Buica, Astrid; Coetzee, Zelmari A; Brand, Jeanne; Schmidtke, Leigh M; Vivier, Melané A

    2016-04-15

    This study investigated the potential to improve wine aroma by applying two inactive dry yeast products (IDYs) at the onset of ripening on Sauvignon Blanc grapes. Both products led to increased reduced glutathione concentrations in the grape juice and corresponding wines, as well as differences in individual higher alcohol acetates (HAAs) and ethyl esters of straight chain fatty acids (EEFAs) at the end of fermentation. After two months of storage, a significantly slower decrease of EEFAs and to a lesser extent of HAAs was found for wines made from grapes with IDY applications. These wines also resulted in significantly slower synthesis of ethyl esters of branched acids, whereas varietal thiols were altered in a product-specific manner. The modifications in the wine chemical composition were also sensorially corroborated. This study showed that vineyard additions of IDY products directly on the grapes at the onset of ripening have a subsequent benefit to the production and preservation of aroma in wines. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Atmospheric heavy metals in high altitude surface snows from Mont Blanc, French Alps

    NASA Astrophysics Data System (ADS)

    Batifol, Francoise M.; Boutron, Claude F.

    We present here the results of the analysis of various surface snow samples collected in the massif of Mont Blanc, French Alps, at three locations whose altitude ranges from 3560 to 4785 m a. s l. These samples were collected using ultra-clean techniques similar to the ones developed for Greenland and Antarctic studies. They were analysed for Pb, Cd, Cu, Zn, Ag, Na, Mg, K, Ca, Fe, Al and Mn by Graphite Furnace Atomic Absorption in clean room conditions. Measured concentrations are very low, then confirming the extreme purity of high altitude snow in the Alps. Principal components factor analysis of the data suggest a crustal source for Na, Mg, K, Ca, Fe, Mn and Al; heavy metals Pb, Cd, Cu, Zn and Ag are found on the other hand to be derived from one or several sources independent of the crustal source. Measured concentrations in snow appear to be closely related to those previously published by other authors for local aerosols.

  14. Influence of grape-harvesting steps on varietal thiol aromas in Sauvignon blanc wines.

    PubMed

    Allen, Thomas; Herbst-Johnstone, Mandy; Girault, Melanie; Butler, Paul; Logan, Gerard; Jouanneau, Sara; Nicolau, Laura; Kilmartin, Paul A

    2011-10-12

    The intense tropical fruit aroma of Sauvignon blanc wines has been associated with the varietal thiols 3-mercaptohexanol (3MH), derived from odorless precursors in the grape, and 3-mercaptohexyl acetate (3MHA), arising from 3MH during fermentation. Grapes and juice were sourced from five locations in Marlborough, New Zealand, taking hand-picked grapes and samples at four stages during the mechanical harvesting process and pressing, which were then fermented in replicated 750 mL bottles. With each set of juices, the highest concentrations of Cys-3MH and Glut-3MH were found in the juices pressed to 1 bar, but these juices produced wines with lower 3MH and 3MHA concentrations. With three of the juices, there was an increase in varietal thiol content for wines made from juices that had been machine harvested compared to the hand-picked samples, which matched earlier findings of lower 3MH and 3MHA levels in wines made from hand-picked grapes. Juices that were more oxidized, and which showed a higher absorbance at 420 nm, were found to produce wines with lower 3MH and 3MHA concentrations.

  15. Nitrogen and carbon assimilation by Saccharomyces cerevisiae during Sauvignon blanc juice fermentation.

    PubMed

    Pinu, Farhana R; Edwards, Patrick J B; Gardner, Richard C; Villas-Boas, Silas G

    2014-12-01

    To investigate the assimilation and production of juice metabolites by Saccharomyces cerevisiae during winemaking, we compared the metabolite profiles of 63 Sauvignon blanc (SB) grape juices collected over five harvesting seasons from different locations of New Zealand before and after fermentation by the commercial wine yeast strain EC1118 at 15 °C. Metabolite profiles were obtained using gas chromatography-mass spectrometry and nuclear magnetic resonance and the oenological parameters were determined by Fourier transform infrared spectroscopy. Our results revealed that the amino acids threonine and serine were the most consumed organic nitrogen sources, while proline and gamma-aminobutyric acid were the least consumed amino acids during SB juice fermentation. Saccharomyces cerevisiae metabolised some uncommon nitrogen sources (e.g. norleucine, norvaline and pyroglutamic acid) and several organic acids, including some fatty acids, most likely after fermenting the main juice sugars (glucose, fructose and mannose). However, consumption showed large variation between juices and in some cases between seasons. Our study clearly shows that preferred nitrogen and carbon sources were consumed by S. cerevisiae EC1118 independent of the juice fine composition, whilst the consumption of other nutrient sources mainly depended on the concentration of other juice metabolites, which explains the uniqueness of each barrel of wine. © 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.

  16. The effect of linoleic acid on the Sauvignon blanc fermentation by different wine yeast strains.

    PubMed

    Casu, Francesca; Pinu, Farhana R; Fedrizzi, Bruno; Greenwood, David R; Villas-Boas, Silas G

    2016-08-01

    The level of linoleic acid in the Sauvignon blanc (SB) grape juice affects the development of different aroma compounds during fermentation by Saccharomyces cerevisiae EC1118, including key varietal thiols such as 3-mercaptohexanol (3MH) and 3-mercaptohexyl acetate (3MHA). However, it is still unknown if linoleic acid would affect in a similar way other commonly used S. cerevisiae wine strains. Here we investigated the effect of grape juice linoleic acid on the development of aroma compounds and other metabolites of SB wines using different wine yeast strains: EC1118, AWRI796 and VIN13. Linoleic acid clearly affected the levels of acetylated aroma compounds, several amino acids, and antioxidant molecules, independent of yeast strain, but the production of 3MH was affected by linoleic acid in a strain-specific manner. Moreover, the supplementation of deuterium-labelled 3MH also affected the production of varietal thiols in a strain-specific way. Linoleic acid reduced the acetylation process probably by inhibiting an acetyltransferase, an effect that was independent of the yeast strain. However, regulation of the 3MH biosynthesis is strain-specific, which suggests a mindful consideration not only towards the wine yeast but also to the linoleic acid concentration in the grape juice in order to obtain the desired wine aroma characteristics. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  17. France Without NATO

    DTIC Science & Technology

    1966-04-08

    Community nations since 1958, France falls well behind Germany and Italy, and just barely above the Netherlands. A more meaning- ful comparison, would be...1965, p. 40. (Information relative to the shifting of the logistical base of NATO from France to the Low Countries.) 39. King, Gillian , ed

  18. Mt. Etna Eruption

    NASA Technical Reports Server (NTRS)

    2002-01-01

    [figure removed for brevity, see original site] [figure removed for brevity, see original site] Figure 1: Vis/NIR Image CloseupFigure 2: Difference Image

    October 2002 Mt. Etna, a volcano on the island of Sicily, erupted on October 26, 2002. Preliminary analysis of data taken by the Atmospheric Infrared Sounder (AIRS) on NASA's Aqua satellite on October 28 shows the instrument can provide an excellent means to study the evolution and structure of the sulfur dioxide (SO2) plume emitted from volcanoes. These data also demonstrate that AIRS can be used to obtain the total mass of SO2 injected into the atmosphere during a volcanic event, information that may help us to better understand these dangerous natural occurrences in the future.

    This image was made from a sensor on the AIRS instrument that is sensitive to the visible and near-infrared portions of the spectrum. The visible/near infrared data show the smoke plume from Mt. Etna. The view is of Europe and the central Mediterranean with Italy in the center. Since the visible/near infrared sensor on AIRS is sensitive to wavelengths that are different than the human eye, vegetated regions appear red (compare the red color of Europe with the tan desert of North Africa in the lower left). Figure 1 is a closer view of Sicily and shows a long, brownish smoke plume extending across the Mediterranean to Africa. This is consistent with the enhanced feature in the difference image in Figure 2 and helps validate the information inferred from that image.

    Figure 2 clearly shows the SO2 plume. This image was created by comparing data taken at two different frequencies, or channels, and creating one image that highlights the differences between these two channels. Both channels are sensitive to water vapor, but one of the channels is also sensitive to SO2. By subtracting out the common water vapor signal in both channels, the SO2 feature remains and shows up as an enhancement in the difference image.

    The

  19. MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.

    PubMed

    Liu, Jiabei; Clough, Shannon J; Hutchinson, Anthony J; Adamah-Biassi, Ekue B; Popovska-Gorevski, Marina; Dubocovich, Margarita L

    2016-01-01

    Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal gland and locally in the retina following a circadian rhythm, with low levels during the day and elevated levels at night. Melatonin activates two high-affinity G protein-coupled receptors, termed MT1 and MT2, to exert beneficial actions in sleep and circadian abnormality, mood disorders, learning and memory, neuroprotection, drug abuse, and cancer. Progress in understanding the role of melatonin receptors in the modulation of sleep and circadian rhythms has led to the discovery of a novel class of melatonin agonists for treating insomnia, circadian rhythms, mood disorders, and cancer. This review describes the pharmacological properties of a slow-release melatonin preparation (i.e., Circadin®) and synthetic ligands (i.e., agomelatine, ramelteon, tasimelteon), with emphasis on identifying specific therapeutic effects mediated through MT1 and MT2 receptor activation. Discovery of selective ligands targeting the MT1 or the MT2 melatonin receptors may promote the development of novel and more efficacious therapeutic agents.

  20. MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective

    PubMed Central

    Liu, Jiabei; Clough, Shannon J.; Hutchinson, Anthony J.; Adamah-Biassi, Ekue B.; Popovska-Gorevski, Marina; Dubocovich, Margarita L.

    2016-01-01

    Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal gland and locally in the retina following a circadian rhythm, with low levels during the day and elevated levels at night. Melatonin activates two high-affinity G protein–coupled receptors, termed MT1 and MT2, to exert beneficial actions in sleep and circadian abnormality, mood disorders, learning and memory, neuroprotection, drug abuse, and cancer. Progress in understanding the role of melatonin receptors in the modulation of sleep and circadian rhythms has led to the discovery of a novel class of melatonin agonists for treating insomnia, circadian rhythms, mood disorders, and cancer. This review describes the pharmacological properties of a slow-release melatonin preparation (i.e., Circadin®) and synthetic ligands (i.e., agomelatine, ramelteon, tasimelteon), with emphasis on identifying specific therapeutic effects mediated through MT1 and MT2 receptor activation. Discovery of selective ligands targeting the MT1 or the MT2 melatonin receptors may promote the development of novel and more efficacious therapeutic agents. PMID:26514204

  1. Repeated Holocene rock avalanches onto the Brenva Glacier, Mont Blanc massif, Italy: A chronology

    NASA Astrophysics Data System (ADS)

    Deline, Philip; Akçar, Naki; Ivy-Ochs, Susan; Kubik, Peter W.

    2015-10-01

    Infrequent rock avalanches (volume ≥1 Mm3) are long-runout processes, especially when travelling onto a glacier, that may threaten populated mountain valleys. Rock avalanches also have strong implications are for relief generation and destruction though time. Both consequences make reconstruction and dating of past events crucial, but dense clusters of events documented in one basin that may improve our knowledge of rock-avalanche frequency and triggering are very rare. Here we propose a chronology of seven of the rock-ice avalanches that affected a steep glacier basin on the southeast side of the Mont Blanc during the late Holocene. A geomorphological study of the runout deposits on the valley floor and the opposite side was combined with the analysis of historical sources and the use of absolute and relative dating methods, especially surface exposure dating with cosmogenic nuclides of 18 granite boulders from two deposits. These rock-ice avalanches are dated AD 1997 and 1920, with a rock volume in the range 2.4-3.6 and 2 × 106 m3, respectively; AD 1767, with a slightly shorter runout; AD 1000-1200, with a longer runout; c. AD 500, the runout of which is uncertain; c. 2500 BP, the determination of which is indirect; and c. 3500 years, with the longest runout. There is no distinct relationship between climatic periods and occurrence of these rock avalanches. Even for the two best documented ones, modelling suggests that the 1997 scar was characterized by a permafrost close to 0 °C, whereas in contrast, the 1920 scar was on the contrary located in cold permafrost.

  2. Coincidences among the data recorded by the Baksan, KAMIOKA and Mont Blanc underground neutrino detectors, and by the Maryland and Rome gravitational-wave detectors during Supernova 1987 A

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Castellina, A.; Fulgione, W.; Trinchero, G.; Vernetto, S.

    1991-04-01

    Data recorded with neutrino detectors at Mont Blanc, Kamioka, and Baksan and with gravitational wave detectors in Maryland and Rome are analyzed. An attempt is made to find correlations associated with SN 1987 A. The time when an excess of coincidences is found is centered at a 5-pulse burst detected at Mont Blanc.

  3. Brief communication: 3-D reconstruction of a collapsed rock pillar from Web-retrieved images and terrestrial lidar data - the 2005 event of the west face of the Drus (Mont Blanc massif)

    NASA Astrophysics Data System (ADS)

    Guerin, Antoine; Abellán, Antonio; Matasci, Battista; Jaboyedoff, Michel; Derron, Marc-Henri; Ravanel, Ludovic

    2017-07-01

    In June 2005, a series of major rockfall events completely wiped out the Bonatti Pillar located in the legendary Drus west face (Mont Blanc massif, France). Terrestrial lidar scans of the west face were acquired after this event, but no pre-event point cloud is available. Thus, in order to reconstruct the volume and the shape of the collapsed blocks, a 3-D model has been built using photogrammetry (structure-from-motion (SfM) algorithms) based on 30 pictures collected on the Web. All these pictures were taken between September 2003 and May 2005. We then reconstructed the shape and volume of the fallen compartment by comparing the SfM model with terrestrial lidar data acquired in October 2005 and November 2011. The volume is calculated to 292 680 m3 (±5.6 %). This result is close to the value previously assessed by Ravanel and Deline (2008) for this same rock avalanche (265 000 ± 10 000 m3). The difference between these two estimations can be explained by the rounded shape of the volume determined by photogrammetry, which may lead to a volume overestimation. However it is not excluded that the volume calculated by Ravanel and Deline (2008) is slightly underestimated, the thickness of the blocks having been assessed manually from historical photographs.

  4. Proteomic Analysis of Sauvignon Blanc Grape Skin, Pulp and Seed and Relative Quantification of Pathogenesis-Related Proteins

    PubMed Central

    Tian, Bin; Harrison, Roland; Morton, James; Deb-Choudhury, Santanu

    2015-01-01

    Thaumatin-like proteins (TLPs) and chitinases are the main constituents of so-called protein hazes which can form in finished white wine and which is a great concern of winemakers. These soluble pathogenesis-related (PR) proteins are extracted from grape berries. However, their distribution in different grape tissues is not well documented. In this study, proteins were first separately extracted from the skin, pulp and seed of Sauvignon Blanc grapes, followed by trypsin digestion and analysis by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). Proteins identified included 75 proteins from Sauvignon Blanc grape skin, 63 from grape pulp and 35 from grape seed, mostly functionally classified as associated with metabolism and energy. Some were present exclusively in specific grape tissues; for example, proteins involved in photosynthesis were only detected in grape skin and proteins found in alcoholic fermentation were only detected in grape pulp. Moreover, proteins identified in grape seed were less diverse than those identified in grape skin and pulp. TLPs and chitinases were identified in both Sauvignon Blanc grape skin and pulp, but not in the seed. To relatively quantify the PR proteins, the protein extracts of grape tissues were seperated by HPLC first and then analysed by SDS-PAGE. The results showed that the protein fractions eluted at 9.3 min and 19.2 min under the chromatographic conditions of this study confirmed that these corresponded to TLPs and chitinases seperately. Thus, the relative quantification of TLPs and chitinases in protein extracts was carried out by comparing the area of corresponding peaks against the area of a thamautin standard. The results presented in this study clearly demonstrated the distribution of haze-forming PR proteins in grape berries, and the relative quantification of TLPs and chitinases could be applied in fast tracking of changes in PR proteins during grape growth and determination of PR

  5. Episodic exhumation and relief growth in the Mont Blanc massif, Western Alps from numerical modelling of thermochronology data

    NASA Astrophysics Data System (ADS)

    Glotzbach, C.; van der Beek, P. A.; Spiegel, C.

    2011-04-01

    The Pliocene-Quaternary exhumational and topographic evolution of the European Alps and its potential climatic and tectonic controls remain a subject of controversy. Here, we apply inverse numerical thermal-kinematic modelling to a spatially dense thermochronological dataset (apatite fission-track and (U-Th)/He) of both tunnel and surface samples across the Mont Blanc massif in the Western Alps, complemented by new zircon fission-track data, in order to better quantify its Neogene exhumation and relief history. Age-elevation relationships and modelling results show that an episodic exhumation scenario best fits the data. Initiation of exhumation in the Mont Blanc massif at 22 ± 2 Ma with a rate of 0.8 ± 0.15 km/Myr is probably related to NW-directed thrusting during nappe emplacement. Exhumation rates decrease at 6 ± 2 Ma to values of 0.15 ± 0.65 km/Myr, which we interpret to be the result of a general decrease in convergence rates and/or extensive exposure of less erodible crystalline basement rocks from below more easily erodible Mesozoic sediments. Finally, local exhumation rates increase up to 2.0 ± 0.6 km/Myr at 1.7 ± 0.8 Ma. Modelling shows that this recent increase in local exhumation can be explained by valley incision and the associated increase in relief at 0.9 ± 0.8 Ma, leading to erosional unloading, isostatic rebound and additional rock uplift and exhumation. Given the lack of tectonic activity as evidenced by constant thermochronological ages along the tunnel transect, we suggest that the final increase in exhumation and relief in the Mont Blanc massif is the result of climate change, with the initiation of mid-Pleistocene glaciations leading to rapid valley incision and related local exhumation.

  6. Hurricanes Frances and Ivan

    Atmospheric Science Data Center

    2014-05-15

    article title:  Cloud Height Maps for Hurricanes Frances and Ivan     ... predict the intensity and amount of rainfall associated with hurricanes still requires improvement, especially on the 24 to 48 hour ...

  7. France in Black Africa,

    DTIC Science & Technology

    1989-01-01

    d’Investissement et de D~vel- oppement Economique et Social (FIDES) (the Fund for Investment and for Economic and Social Development). The new constitution...de Cooperation (FAC). CCFOM became the Caisse Cen- trale de Cooperation Economique (CCCE). The Minis- try of Overseas France, with its headquarters on...Ministry in "La France et l’Afrique: Etude des relations Franco-Africaines politiques, finan- cires, economiques , commerciales et culturelles," Paris, 1984

  8. Modelling Mt. Etna mantle sources

    NASA Astrophysics Data System (ADS)

    Casetta, Federico; Giacomoni, Pier Paolo; Coltorti, Massimo; Ferlito, Carmelo; Bonadiman, Costanza

    2017-04-01

    The mantle source beneath Mt. Etna is matter of a longstanding and controversial debate, due to the absence of mantle xenoliths, the evolved nature of the erupted magmas and their geochemical variations. This study is focused on the modelling of the petrogenetic processes responsible for the production of Mt. Etna magmas and their variation through time, by means of a comparison with the Hyblean lavas (Southern Sicily), their evolution and mantle source(s). Samples from all Mt. Etna eruptive events, from the tholeiites to the nowadays K-rich eruptions, were used to a backward reconstruction of the primitive magma compositions, taking into account the fO2 of the magmatic system and its effect on mineral-melt Fe partitioning. The eutectic melting proportions and the modal composition of the Mt. Etna mantle source, obtained by a mass balance melting model, allowed to: i) compare the etnean inferred primary magmas with the Ol-hosted melt inclusions (MI) composition and with the Hyblean real primary magmas; ii) define some petrologic and geodynamic constraints on the Hyblean-Mt. Etna area taking also in account the compositions of the Hyblean xenoliths. A 2% to 17% addition of dunitic to wehrlitic assemblages (Ol + Cpx in progressive equilibrium) to Mt. Etna less evolved lavas allowed to equilibrate the Mt. Etna primitive magmas (mg# = 68) compositions for Timpe, AAV, Ellittico, Mongibello and Post-1971 stages to mantle conditions; Ol with Fo=88). The calculated Lh source is constituted by Ol + Opx + Cpx + Cr-Sp, with addition of small amounts (4.3%) of Amph and Phlog. Decreasing partial melting degrees (from 19% to 13-10%) and a change in Amph and Phlog eutectic melting proportions can explain the entire Mt. Etna compositional range, from the tholeiitic event to the Post-1971 LILE-enriched episodes, leading to the production of primary magmas characterized by a 0.6 to 1.2 wt% H2O content. Some speculation between geodynamic and magmatic evolution of the articulated and

  9. Effect of inert gas and prefermentative treatment with polyvinylpolypyrrolidone on the phenolic composition of Chilean Sauvignon blanc wines.

    PubMed

    Cáceres-Mella, Alejandro; Peña-Neira, Álvaro; Parraguez, Jenny; López-Solís, Remigio; Laurie, V Felipe; Canals, Joan Miquel

    2013-06-01

    Sauvignon blanc wines are produced under a wide variety of winemaking conditions, some of which include different fruit-ripening levels, cold soaks and the use of fining agents and inert gases. Anecdotal evidence suggests that sensory variations among these wines may have to do with their phenolic composition and concentration. Therefore the aim of this work was to study the effects of different winemaking conditions typically used in Chile on the phenolic composition and concentration of Sauvignon blanc wines. The use of an inert gas (CO2) in winemaking produced differences in the proportion of proanthocyanidin fractions. A higher concentration of flavan-3-ol monomers resulted from winemaking in the presence of inert gas. This condition also produced a higher content of total phenols and low-molecular-weight phenolic compounds. Low doses of polyvinylpolypyrrolidone (PVPP) in the prefermentative treatments produced wines with a higher content of phenolic compounds. Under these conditions a higher content of polymeric proanthocyanidins was observed. Different winemaking conditions modified the concentration and proportion of proanthocyanidin fractions and the global phenolic composition of the resulting white wines. This should be taken into account by the wineries producing these wines. © 2012 Society of Chemical Industry.

  10. Exploration of consumer perception of Sauvignon Blanc wines with enhanced aroma properties using two different descriptive methods.

    PubMed

    Lezaeta, Alvaro; Bordeu, Edmundo; Næs, Tormod; Varela, Paula

    2017-09-01

    The aim of this study was to evaluate consumers' perception of a complex set of stimuli as aromatically enriched wines. For that, two consumer based profiling methods were compared, concurrently run with overall liking measurements: projective mapping based on choice or preference (PM-C), a newly proposed method, and check-all-that-apply (CATA) questions with an ideal sample, a more established, consumer-based method for product optimization. Reserve bottling and regular bottling of Sauvignon Blanc wines from three wineries were aromatically enriched with natural aromas collected by condensation during wine fermentation. A total of 144 consumers were enrolled in the study. The results revealed that both consumer-based highlighted the positive effect of aromatic enrichment on consumer perception and acceptance. However, PM-C generated a very detailed description, in which consumers focused less on the sensory aspects and more on the usage, attitudes, and reasons behind their choices. Providing a deeper understanding of the drivers of liking/disliking of enriched Sauvignon Blanc wines. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Combined Effects of Early Season Leaf Removal and Climatic Conditions on Aroma Precursors in Sauvignon Blanc Grapes.

    PubMed

    Sivilotti, Paolo; Falchi, Rachele; Herrera, Jose Carlos; Škvarč, Branka; Butinar, Lorena; Sternad Lemut, Melita; Bubola, Marijan; Sabbatini, Paolo; Lisjak, Klemen; Vanzo, Andreja

    2017-09-27

    Early leaf removal around the cluster zone is a common technique applied in cool climate viticulture, to regulate yield components and improve fruit quality. Despite the increasing amount of information on early leaf removal and its impact on total soluble solids, anthocyanins, and polyphenols, less is known regarding aroma compounds. In order to verify the hypothesis that defoliation, applied before or after flowering, could impact the biosynthesis of thiol precursors, we performed a two year (2013 and 2014) experiment on Sauvignon blanc. We provided evidence that differential accumulation of thiol precursors in berries is affected by the timing of defoliation, and this impact was related to modifications in the biosynthetic pathway. Furthermore, the possible interaction between leaf removal treatment and seasonal weather conditions, and its effect on the biosynthesis of volatile precursors are discussed. Our results suggested that in Sauvignon blanc the relative proportion of 4-S-glutathionyl-4-methylpentan-2-one (G-4MSP) and 3-S-glutathionylhexan-1-ol (G-3SH) precursors can be affected by defoliation, and this could be related to the induction of two specific genes encoding glutathione-S-transferases (VvGST3 and VvGST5), while no significant effects on basic fruit chemical parameters, polyphenols, and methoxypyrazines were ascertained under our experimental conditions.

  12. Recreation conflicts on Mt. Evans

    Treesearch

    Jerry J. Vaske; Karin Wittmann; Susan Laidlaw; Maureen P. Donnelly

    1995-01-01

    This study examines recreation conflict at Mt. Evans, Colorado; a high visibility area that attracts both hunters and non-hunters. Two types of conflict were distinguished: goal interference and conflict of values. Data were obtained from a series of on-site and mailed surveys. For hunting related events (e.g. seeing an animal being shot, hearing...

  13. The Mt. Mitchell scenery assessment

    Treesearch

    Robert F. Scheele; Gary W. Johnson

    1979-01-01

    The scenery assessment process for the Mt. Mitchell Suitability/Feasibility Study was conducted by National Park Service personnel and consultants in 1977-78. It combined approaches designed by Lewis (1962) and Jones (1976) in a comparative evaluation of the scenery of two large landscapes in the Appalachian physiographic province. The purpose of this study was to...

  14. Mt. SAC Research Briefs, 2000.

    ERIC Educational Resources Information Center

    Mt. SAC Research Briefs, 2000

    2000-01-01

    These Research Briefs examine Mt. San Antonio College District's (MSAC's) (California) enrollment trends. Over the last few years, the district has drawn a large number of students from surrounding areas; however, there are concerns as to whether this fact will remain the same as new forms of educational techniques such as distance education and…

  15. Study of Chardonnay and Sauvignon blanc wines from D.O.Ca Rioja (Spain) aged in different French oak wood barrels: Chemical and aroma quality aspects.

    PubMed

    Herrero, Paula; Sáenz-Navajas, María Pilar; Avizcuri, José Miguel; Culleré, Laura; Balda, Pedro; Antón, Elena C; Ferreira, Vicente; Escudero, Ana

    2016-11-01

    This study discusses chemical data corresponding to the analysis of twenty-one wood-extractable aromatic compounds in twenty-four different barrels varying in the toasting level at three sampling times: at the end of the alcoholic fermentation and after 5 and 12months of aging. Twelve barrels contained monovarietal Chardonnay wine while the other twelve barrels contained Sauvignon blanc wine. The levels of nearly all the analyzed compounds increased with the aging time, with the exception of vinylphenols and methyl vanillate, which decreased. These latter compounds had significantly higher levels in the Chardonnay wines than in the Sauvignon blanc. Furfural, guaiacol and vanillin derivatives increased with the toasting level. ANOVA study showed significant interactions between the toasting level and aging time as well as between the variety and aging time, which revealed significant differences in the levels of the compounds studied in the wines dependent on the toasting level, variety and aging time. Quality perception based exclusively on orthonasal aroma stimuli was evaluated by a panel of Spanish wine professionals in 12-month aged wines belonging to both grape varieties. Experts from D.O.Ca Rioja aroma did not share a common aroma quality concept for aged Chardonnay and Sauvignon blanc wines. Considering the cluster formed by the majority of experts (76%) for the Chardonnay and cluster 1 (56%) for Sauvignon blanc, quality scores were negatively correlated with the concentration level of 4-vinylphenol and positively with the concentration level of (E)-isoeugenol. The opposite was observed for cluster 2 (44%) identified for Sauvignon blanc wines. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. [Anesthesiologists in France].

    PubMed

    Mizuno, Ju; Hanaoka, Kazuo; Merckx, Paul; Bonneville, Claire Tae; Kavafyan, Juliette; Mantz, Jean

    2007-03-01

    We review some anesthesiologist's curriculum and demographic characteristics in France to the community of Japanese anesthesiologists. To become a certified anesthesiologist and an intensive care physician currently requires six years' medical education, passing national medical examination, and five years' special training as an intern of anesthesiology and intensive care. This educational course was started in 1984. There are 7942 certified anesthesiologists in France in 1999. The average age is 45.9 years and the ratio of female is 35.3%. Approximately two thirds of certified anesthesiologists are working in public institutions. 89% is full-time workers. More than half of certified anesthesiologists actually participate in daily intensive care practice. The number of certified anesthesiologists has been increasing gradually totaling 10,062 persons in 2005. The number of certified anesthesiologists per ten thousands general population is 1.7 persons and the corresponding ratio to all medical doctors is 4.8%. Working hours and holidays are regulated by the French Labour Law. The anaesthesiologist often works in a team with a nurse anaesthetist. The number of certified anesthesiologists in France is larger than that in Japan. Management of anesthesia in France seems to have an advantage in manpower.

  17. Chikungunya Virus, Southeastern France

    PubMed Central

    Caro, Valérie; Plumet, Sébastien; Thiberge, Jean-Michel; Souarès, Yvan; Failloux, Anna-Bella; Tolou, Hugues J.; Budelot, Michel; Cosserat, Didier; Leparc-Goffart, Isabelle; Desprès, Philippe

    2011-01-01

    In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present. Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus in Europe. PMID:21529410

  18. Country Profiles. France.

    ERIC Educational Resources Information Center

    Bourgeois-Pichat, Jean

    A profile of France is sketched in this paper. Emphasis is placed on the nature, scope, and accomplishments of population activities in the country. Topics and sub-topics include: (1) location and description of the country; (2) population--size, growth patterns, age structure, urban/rural distribution, ethnic and religious composition, education,…

  19. France. [CME Country Reports].

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Documentation Center for Education in Europe.

    In France, the 1882 Compulsory Education Act includes both French and foreign children. Since then, the need to go further than this general principle of non-discrimination and to undertake specific action for immigrants, both adults and children, has been recognized. Since 1970, the Ministry of Education has been directly responsible for this…

  20. Industrial Psychology in France

    ERIC Educational Resources Information Center

    de Montmollin, Maurice

    1977-01-01

    The current status of French industrial psychology is evaluated. Within the social and economic context of contemporary France, varying ideologies and scarce resources have created a gap between applied and academic industrial psychology. Personnel practices and systems and organizational research are noted. (Editor)

  1. Technological Elites in France.

    ERIC Educational Resources Information Center

    Trilling, Leon

    1988-01-01

    Compares the training and activity of scientists and engineers in France and the United States. Describes the French higher education system including the features and curriculum design of the "grandes ecoles." Discusses the differences in the role of government to research and development between the two nations. (YP)

  2. France. [CME Country Reports].

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Documentation Center for Education in Europe.

    In France, the 1882 Compulsory Education Act includes both French and foreign children. Since then, the need to go further than this general principle of non-discrimination and to undertake specific action for immigrants, both adults and children, has been recognized. Since 1970, the Ministry of Education has been directly responsible for this…

  3. English Teaching Profile: France.

    ERIC Educational Resources Information Center

    British Council, London (England). English Language and Literature Div.

    This review of the status of English language instruction in France provides an overview of the role of English in the society in general and outlines the status of English in the educational system at the elementary, secondary, higher, and vocational levels. The following topics are covered: instruction in English for special purposes, the…

  4. Linguistic Pluralism in France.

    ERIC Educational Resources Information Center

    Laroche, Jacques M.

    This paper suggests that a discussion of linguistic pluralism in France begins by chronicling the emergence of French as the primary language in early French history and the role of linguistic minorities at various periods in French history. It then focuses on growing linguistic activism in the second half of the twentieth century, when the…

  5. [Psychosocial rehabilitation in France].

    PubMed

    Vidon, Gilles

    2015-01-01

    For a long time in France, readaptation and reinsertion have been considered separately. While readaptation focuses on the way the patient "adapts again", reintegration looks at the place of the readaptation, the society or the group. Today, psychosocial rehabilitation encompasses both of these notions by taking into account the medical and social aspects.

  6. Urban Sociology in France.

    ERIC Educational Resources Information Center

    Amiot, Michel

    1986-01-01

    Divides the history of urban sociology in France into three periods: (1) functionalism, which lasted from 1910 until the 1960s, (2) neo-Marxist socioeconomics lasting from 1968 until 1979, and (3) anthropological approach which is still dominant. Reviews theoretical perspectives and research characteristic of each period. (JDH)

  7. Traveling in France.

    ERIC Educational Resources Information Center

    Philyaw, Henry; And Others

    This minicourse guide for teachers of French is intended to help motivate and prepare students for travel in France. Activities are outlined in eleven related areas, including (1) planning for the trip, (2) currency, (3) going through customs, (4) tipping, (5) shopping, (6) guided tours, (7) touring on your own, (8) social life and entertainment,…

  8. Electricite de France`s ALARA policy

    SciTech Connect

    Stricker, L.; Rollin, P.

    1995-03-01

    In 1992, Electricite de France - EDF decided to improve the degree to which radiological protection is incorporated in overall management of the utility and set itself the objective of ensuring the same level of protection for workers from contractors as for those from EDF. This decision was taken in a context marked by a deterioration in exposure figures for French plants and by the new recommendations issued by the ICRP. This document describes the policy adopted by EDF at both corporate and plant level to meet these objectives, by: (1) setting up management systems which were responsive but not cumbersome; (2) a broad policy of motivation; (3) the development and use of suitable tools. The document then describes some quite positive results of EDF`s ALARA policy, giving concrete examples and analyzing the changes in global indicators.

  9. [Primary care in France].

    PubMed

    Sánchez-Sagrado, T

    2016-01-01

    The poor planning of health care professionals in Spain has led to an exodus of doctors leaving the country. France is one of the chosen countries for Spanish doctors to develop their professional career. The French health care system belongs to the Bismarck model. In this model, health care system is financed jointly by workers and employers through payroll deduction. The right to health care is linked to the job, and provision of services is done by sickness-funds controlled by the Government. Primary care in France is quite different from Spanish primary care. General practitioners are independent workers who have the right to set up a practice anywhere in France. This lack of regulation has generated a great problem of "medical desertification" with problems of health care access and inequalities in health. French doctors do not want to work in rural areas or outside cities because "they are not value for money". Medical salary is linked to professional activity. The role of doctors is to give punctual care. Team work team does not exist, and coordination between primary and secondary care is lacking. Access to diagnostic tests, hospitals and specialists is unlimited. Duplicity of services, adverse events and inefficiencies are the norm. Patients can freely choose their doctor, and they have a co-payment for visits and hospital care settings. Two years training is required to become a general practitioner. After that, continuing medical education is compulsory, but it is not regulated. Although the French medical Health System was named by the WHO in 2000 as the best health care system in the world, is it not that good. While primary care in Spain has room for improvement, there is a long way for France to be like Spain. Copyright © 2015 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  10. Pharmacy Education in France

    PubMed Central

    Bourdon, Olivier; Ekeland, Catherine

    2008-01-01

    In France, to practice as a pharmacist, one needs a “diplome d'état de Docteur en Pharmacie” This degree is awarded after 6 or 9 years of pharmacy studies, depending on the option chosen by the student. The degree is offered only at universities and is recognized in France as well as throughout the European Union. Each university in France is divided into faculties called Unité de Formation et de Recherche (UFR). There are 24 faculties of pharmacy or UFRs de pharmacie. A national committee develops a pharmacy education program at the national level and each faculty adapts this program according to its specific features and means (eg, faculty, buildings). The number of students accepted in the second year is determined each year by a Government decree (numerus clausus). Successive placements, totalling 62 weeks, progressively familiarize the student with professional practice, and enable him/her to acquire the required competencies, such as drug monitoring and educating and counselling patients. Challenges facing community pharmacies in the next 10 years are patient education, home health care, and orthopaedics; in hospital pharmacies, empowering pharmacists to supervise and validate all prescriptions; and finally, research in pharmacy practice. PMID:19325952

  11. Terrorism in France.

    PubMed

    Carli, Pierre; Telion, Caroline; Baker, David

    2003-01-01

    France has experienced two waves of major terrorist bombings since 1980. In the first wave (1985-1986), eight bombings occurred in Paris, killing 13 and injuring 281. In the second wave (1995-1996), six bombings occurred in Paris and Lyon, killing 10 and injuring 262. Based on lessons learned during these events, France has developed and improved a sophisticated national system for prehospital emergency response to conventional terrorist attacks based on its national emergency medical services (EMS) system, Service d'Aide Medicale Urgente (SAMU). According to the national plan for the emergency medical response to mass-casualty events (White Plan), the major phases of EMS response are: (1) alert; (2) search and rescue; (3) triage of victims and provision of critical care to first priority victims; (4) regulated dispatch of victims to hospitals; and (5) psychological assistance. Following the 1995 Tokyo subway sarin attack, a national plan for the emergency response to chemical and biological events (PIRATOX) was implemented. In 2002, the Ministries of Health and the Interior collaborated to produce a comprehensive national plan (BIOTOX) for the emergency response to chemical, biological, radiological, and nuclear events. Key aspects of BIOTOX are the prehospital provision of specialized advance life support for toxic injuries and the protection of responders in contaminated environments. BIOTOX was successfully used during the 2003 Severe Acute Respiratory Syndrome (SARS) outbreak in France.

  12. Onboard Photo of Mt. Everest

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Astronaut Daniel W. Bursch, Expedition Four flight engineer, was delighted in capturing this image of Mt. Everest in the Himalayan Range from aboard the International Space Station (ISS). The mountain is near frame center. Because the photo was taken close to orbital sunrise, the low sun angle gave tremendous relief to the mountains. Named for Sir George Everest, the British surveyor-general of India, Mount Everest is the tallest point on earth. Standing 29,028 feet tall, it is 5 1/2 miles above sea level. Mount Everest is located half in Nepal and half in Tibet.

  13. SN 1987 A - Correlations between the Maryland and Rome gravitational wave detector data and the Mont Blanc and KAMIOKANDE neutrino detector data

    NASA Astrophysics Data System (ADS)

    Pallottino, G. V.

    1990-02-01

    The paper describes the analysis of data obtained in the period 12 h of February 22, 1987 to 6 h of February 23, 1987, that includes the time of neutrino observation with the Mont Blanc detector during SN 1987 A. A very significant correlation has been observed among the data of the above detectors in a period of one or two hours which includes the time of the Mont Blanc 5-neutrino observation. The correlation between the gravitational wave detector data and the Kamiokande data is found if a time of 7.8 s is added to the Kamioka recorded time; this is very close to the time difference, 6.2 s, between the IMB and Kamioka large neutrino bursts observed at about 7 h 35 min.

  14. Correlation between the Maryland and Rome gravitational-wave detectors and the Mont Blanc, Kamioka and IMB particle detectors during SN 1987A.

    NASA Astrophysics Data System (ADS)

    Aglietta, M.; Castellina, A.; Fulgione, W.; Trinchero, G.; Vernetto, S.; Astone, P.; Badino, G.; Bologna, G.; Bassan, M.; Coccia, E.; Modena, I.; Bonifazi, P.; Castellano, M. G.; Visco, M.; Castagnoli, C.; Galeotti, P.; Saavedra, O.; Cosmelli, C.; Frasca, S.; Pallottino, G. V.; Pizzella, G.; Rapagnani, P.; Ricci, F.; Majorana, E.; Gretz, D.; Weber, J.; Wilmot, G.

    1991-11-01

    Following a previously found correlation between the gravitational-wave detectors and the Mont Blanc particle detector, the authors have searched for a similar correlation between the data of the experiments mentioned in the title. They have found that both the Kamioka and the IMB data have a correlation with the gravitational-wave data that occurs with the same characteristics and at the same time of that already found with Mont Blanc. This correlation extends for a period of one or two hours centred at the hour 2:45 UT of 23 February 1987. It shows that the particle detector signals are delayed with respect to the gravitational-wave detector signals by (1.2±0.5)s. The probability that the additional correlation due to Kamioka and IMB is only accidental is estimated of the order of 10-3 or 10-4.

  15. Vulnerability of settlements around Mt. Cameroon volcano, Cameroon

    NASA Astrophysics Data System (ADS)

    Zogning, Appolinaire; Spinetti, Claudia; Ngouanet, Chretien; Tchoudam, David; Kouokam, Emmanuel; Thierry, Pierre; Bignami, Christian; Fabrizia Buongiorno, Maria; Ilaria Pannaccione Apa, Maria

    2010-05-01

    Located at the bottom of the Gulf of Guinea, Cameroon is exposed to a large variety of natural hazards, including volcanism. Most of the hazard are concentrated around the active volcano Mt. Cameroon which combines effusive and explosive types of activity. The threatened stakes are numerous and different exposed: people, settlements, industrial plantations, petrol refinery and many other factories and infrastructures. Until 2005, no risk management plans has been available. In 2006, the French Embassy in Cameroon, within the framework of a financial convention between Cameroon and France, put in place the GRINP (Management of Natural Risks and Civil Protection) project whose objective was to reinforce the capacity of Cameroon's civil protection department and thus, contribute to the improvement of the security of the population faced with catastrophes. The objective was to realize a Risk Prevention Plan at a local council scale, and taking into consideration the specific natural risks of each zone. The general objective of the RPP was to clearly draw land use maps for risks zones, showing the overlay of stakes with risk of different intensities. In 2008 European Commission funded the Mia-Vita project (Mitigating and Assessing Volcanic Impacts on Terrain and human Activities). The aim of the project is to improve the crisis management capabilities based on monitoring and early warning systems and secure communications; reduction of people's vulnerability and development of recovering capabilities after an event occurs for both local communities and ecological systems. Keyword: natural hazards, Mt. Cameroon, vulnerability, risk prevention plan

  16. Thermal and structural evolution of the external Western Alps: Insights from (U-Th-Sm)/He thermochronology and RSCM thermometry in the Aiguilles Rouges/Mont Blanc massifs

    NASA Astrophysics Data System (ADS)

    Boutoux, A.; Bellahsen, N.; Nanni, U.; Pik, R.; Verlaguet, A.; Rolland, Y.; Lacombe, O.

    2016-06-01

    In the Western Alps, the External Crystalline Massifs (ECM) are key places to investigate the kinematics and thermal structure of a collisional crustal wedge, as their paleo-brittle/ductile transition is now exhumed at the surface. New (U-Th-Sm)/He data on zircon and new Raman Spectroscopy on Carbonaceous Material (RSCM) data from the Aiguilles Rouges and the Mont Blanc massifs, coupled to HeFTy thermal modeling, constrain the thermal evolution and exhumation of the massifs. In the cover of the Aiguilles Rouges massif, we found that the maximal temperature was about 320 °C (+/- 25 °C), close to the maximal temperature reached in the cover of the Mont Blanc massif ( 350 °C +/- 25 °C). We show that, after a fast heating period, the thermal peak lasted 10-15 Myrs in the Mont Blanc massif, and probably 5-10 Myrs in the Aiguilles Rouges massif. This thermal peak is synchronous with crustal shortening documented in the basement. (U-Th-Sm)/He data and thermal modeling point toward a coeval cooling of both massifs, like other ECM, at around 18 Ma +/- 1 Ma. This cooling was related to an exhumation due to the initiation of frontal crustal ramps below the ECM, quite synchronously along the Western Alps arc.

  17. Incineration of municipal and assimilated wastes in France: assessment of latest energy and material recovery performances.

    PubMed

    Autret, Erwan; Berthier, Francine; Luszezanec, Audrey; Nicolas, Florence

    2007-01-31

    Incineration has an important place in waste management in France. In 2003, around 130 incineration plants have treated 12.6 Mt of non-dangerous waste, mainly composed of household waste (10.8 Mt), non-dangerous waste from industry, business, services (1.0 Mt), sewage sludge (0.2 Mt) or clinical waste (0.1 Mt). The incineration of these wastes generated 3.0 Mt of bottom ash of which 2.3 Mt were used for roads construction and 0.2 Mt of ferrous and non-ferrous metal were recycled. It also produced 2,900,000 MWh of electricity, of which 2,200,000 MWh were sold to Electricité de France (EDF) and 9,100,000 MWh of heat, of which 7,200,000 MWh were sold to private or public users. These French incinerators of non-hazardous waste are currently being thoroughly modernized, thus making possible the consolidation and the enhancement of their environmental and energy performance. This process is related to the implementation of the European Directive 2000/76/CE whose expiration date is 28 December 2005. Upon request of ADEME, the engineering company GIRUS has realised the first technical and economical evaluation of works necessary to bring incinerators into compliance. The financial estimations, carried out in 30 June 2003, show that the investments to be devoted could reach 750 million euros. This assessment shed new light on the situation of non-hazardous waste incinerators, including an identification and a rank ordering for each incinerator of the most frequent and the most complex non-conformities to be solved in term of cost and delay. At last, this assessment gives the solutions for each non-compliance.

  18. ASTER Images Mt. Usu Volcano

    NASA Image and Video Library

    2000-04-26

    On April 3, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra Satellite captured this image of the erupting Mt. Usu volcano in Hokkaido, Japan. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER will image the Earth for the next 6 years to map and monitor the changing surface of our planet. This false color infrared image of Mt Usu volcano is dominated by Lake Toya, an ancient volcanic caldera. On the south shore is the active Usu volcano. On Friday, March 31, more than 11,000 people were evacuated by helicopter, truck and boat from the foot of Usu, that began erupting from the northwest flank, shooting debris and plumes of smoke streaked with blue lightning thousands of feet in the air. Although no lava gushed from the mountain, rocks and ash continued to fall after the eruption. The region was shaken by thousands of tremors before the eruption. People said they could taste grit from the ash that was spewed as high as 2,700 meters (8,850 ft) into the sky and fell to coat surrounding towns with ash. "Mount Usu has had seven significant eruptions that we know of, and at no time has it ended quickly with only a small scale eruption," said Yoshio Katsui, a professor at Hokkaido University. This was the seventh major eruption of Mount Usu in the past 300 years. Fifty people died when the volcano erupted in 1822, its worst known eruption. In the image, most of the land is covered by snow. Vegetation, appearing red in the false color composite, can be seen in the agricultural fields, and forests in the mountains. Mt. Usu is crossed by three dark streaks. These are the paths of ash deposits that rained out from eruption plumes two days earlier. The prevailing wind was from the northwest, carrying the ash away from the main city of Date. Ash deposited can be traced on the image as far away as 10 kilometers (16 miles

  19. Functional MT + lesion impairs contralateral motion processing.

    PubMed

    Moo, Lauren R; Emerton, Britt C; Slotnick, Scott D

    2008-07-01

    Human motion processing region MT + is retinotopically organized with perception of and attention to motion in the right visual field preferentially associated with left MT + activity and vice versa. However, the degree to which MT + is crucial for motion processing is uncertain. We report an epilepsy patient with visual symptoms early in his seizure evolution and a left temporal-occipital seizure onset electrographically in whom we hypothesized a functional left MT + lesion. The patient was impaired in his right but not left visual field on a hemifield motion attention task and demonstrated worse performance on a hemifield picture identification task when pictures implying motion were presented in the right as opposed to the left visual field. Functional MRI (fMRI) during a full-field motion detection task activated right MT + but failed to activate left MT + despite activating both left and right MT + in each of 10 controls. Furthermore, fMRI during a hemifield motion attention task also showed a lack of left MT + attention effects in the patient. Together these results suggest that MT + is necessary for normal motion processing.

  20. European security and France

    SciTech Connect

    deRose, A.

    1985-01-01

    A French authority on security argues for new European initiatives in the face of the ''danger represented by Soviet military power deployed in support of an imperialistic ideology.'' His proposals, including the strengthening of conventional forces without abandoning the option of the first use of nuclear weapons, are meant to give substance to President Mitterrand's declaration in 1983: ''The European nations now need to realize that their defense is also their responsibility....'' A part of the increasingly important debate in France over defense policy in Europe.

  1. City of Paris, France

    NASA Image and Video Library

    1992-09-20

    STS047-94-010 (12 - 20 Sept 1992) --- This 250mm Hasselblad color photo of Paris, France recorded during this mission, shows urban land uses in great detail. Several airports are clear, including the two major international airports of Orly and Le Bourget. Paris was founded in pre-Roman times on an island in the Seine River and continued as a Roman outpost. The easily defensible location was one of the keys to the growth of this island city. The city expanded from its island state to become a major urban center in Europe because of its location, its easy access by river traffic, and its productive hinterland.

  2. Battle of France WWII

    NASA Astrophysics Data System (ADS)

    Gadhath, Arpitha Rao

    The purpose of this thesis is to build an interactive Geographical Information System (GIS) tool, relating to the series of events that occurred during the Battle of France World War II. The tool gives us an insight about the countries involved in the battle, their allies and their strategies. This tool was created to use it as a one stop source of information regarding all the important battles that took place, which lead to the fall of France. The tool brings together the maps of all the countries involved. Integrated with each map is the data relevant to that map. The data for each country includes the place of attack, the strategies used during the attack, and the kind of warfare. The tool also makes use of HTML files to give all the information, along with the images from the time of the war and a footage which explains everything about the particular battle. The tool was build using JAVA, along with the use of MOJO (Map Objects Java Objects) to develop Maps of each of the countries. MOJO is developed by ESRI (Environmental Science Research Institute) which makes it easier to add data to the maps. It also makes highlighting important information easier making use of pop-up windows, charts and infographics. HTML files were designed making use of the open-source template developed by Bootstrap. The tool is built in such a way that the interface is simple and easy for the user to use and understand.

  3. Legionnaires' disease in France.

    PubMed

    Campèse, C; Descours, G; Lepoutre, A; Beraud, L; Maine, C; Che, D; Jarraud, S

    2015-03-01

    The aim of this review was to describe the current knowledge of Legionnaires' disease (LD) illustrated by the epidemiological situation in France in 2013. LD is a severe pneumonia commonly caused by Legionella pneumophila serogroup 1. The diagnosis is usually based on the urinary antigen test. This rapid method reduces the delay between clinical suspicion and initiation of an appropriate treatment. However, the availability of a clinical strain is important to improve knowledge of circulating bacteria, to document case clusters, and to identify the sources of contamination. The source of contamination is unknown in most cases. The main contamination sources generating aerosols are water network systems and cooling towers. Thanks to the strengthening of clinical and environmental monitoring and to several guidelines, no epidemic has been reported in France since 2006. Despite these efforts, the number of LD cases has not decreased in recent years. It is essential that applied research continue to better understand the spatial and temporal dynamics of the disease and its characteristics (impact of environmental factors, sources of exposure, strains, host, etc.). Fundamental knowledge has been greatly improved (pathogenesis, immune mechanisms, etc.). The results of this research should help define new strategies for the diagnosis, prevention, and control to decrease the number of LD cases diagnosed every year.

  4. Impacts of the 2003 and 2015 summer heatwaves on permafrost-affected rock-walls in the Mont Blanc massif.

    PubMed

    Ravanel, L; Magnin, F; Deline, P

    2017-07-20

    Rockfall is one of the main geomorphological processes that affects the evolution and stability of rock-walls. At high elevations, rockfall is largely climate-driven, very probably because of the warming of rock-wall permafrost. So with the ongoing global warming that drives the degradation of permafrost, the related hazards for people and infrastructure could continue to increase. The heatwave of summer 2015, which affected Western Europe from the end of June to August, had a serious impact on the stability of high-altitude rock-walls, including those in the Mont Blanc massif. A network of observers allowed us to survey the frequency and intensity of rock-wall morphodynamics in 2015, and to verify its relationship with permafrost. These observations were compared with those of the 2003 summer heatwave, identified and quantified by remote sensing. A comparison between the two years shows a fairly similar rockfall pattern in respect of total volumes and high frequencies (about 160 rockfalls >100m(3)) but the total volume for 2003 is higher than the 2015 one (about 300,000m(3) and 170,000m(3) respectively). In both cases, rockfalls were numerous but with a low magnitude and occurred in permafrost-affected areas. This suggests a sudden and remarkable deepening of the active layer during these two summers, rather than a longer-term warming of the permafrost body. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Clonal differences and impact of defoliation on Sauvignon blanc (Vitis vinifera L.) wines: a chemical and sensory investigation.

    PubMed

    Šuklje, Katja; Antalick, Guillaume; Buica, Astrid; Langlois, Jennifer; Coetzee, Zelmari A; Gouot, Julia; Schmidtke, Leigh M; Deloire, Alain

    2016-02-01

    The aim of this study, performed on Sauvignon blanc clones SB11 and SB316, grafted on the same rootstock 101-14 Mgt (Vitis riparia × V. ruperstris) and grown at two adjacent vineyards, was two-fold: (1) to study wine chemical and sensory composition of both clones within an unaltered canopy; and (2) to determine the effect of defoliation (e.g. bunch microclimate) on wine chemical and sensory composition. Orthogonal projection to latent structures discriminate analysis (OPLS-DA) was applied to the concentration profiles of volatile compounds derived from gas chromatography-mass spectrometry data. The loadings directions inferred that 3-isobutyl-2-methoxypyrazine (IBMP) discriminated control treatments (shaded fruit zone) of both clones from defoliation treatments (exposed fruit zone), whereas 3-sulfanyl-hexan-1-ol (3SH), 3-sulfanylhexyl acetate (3SHA), hexanol, hexyl hexanoate and some other esters discriminated defoliated treatments from the controls. The OPLS-DA indicated the importance of IBMP, higher alcohol acetates and phenylethyl esters, for discrimination of clone SB11 from clone SB316 irrespective of the treatment. Defoliation in the fruit zone significantly decreased perceived greenness in clone SB11 and elevated fruitier aromas, whereas in clone SB316 the effect of defoliation on wine sensory perception was less noticeable regardless the decrease in IBMP concentrations. These findings highlight the importance of clone selection and bunch microclimate to diversify produced wine styles. © 2015 Society of Chemical Industry.

  6. Dynamic study of yeast species and Saccharomyces cerevisiae strains during the spontaneous fermentations of Muscat blanc in Jingyang, China.

    PubMed

    Wang, Chunxiao; Liu, Yanlin

    2013-04-01

    The evolution of yeast species and Saccharomyces cerevisiae genotypes during spontaneous fermentations of Muscat blanc planted in 1957 in Jingyang region of China was followed in this study. Using a combination of colony morphology on Wallerstein Nutrient (WLN) medium, sequence analysis of the 26S rDNA D1/D2 domain and 5.8S-ITS-RFLP analysis, a total of 686 isolates were identified at the species level. The six species identified were S. cerevisiae, Hanseniaspora uvarum, Hanseniaspora opuntiae, Issatchenkia terricola, Pichia kudriavzevii (Issatchenkia orientalis) and Trichosporon coremiiforme. This is the first report of T. coremiiforme as an inhabitant of grape must. Three new colony morphologies on WLN medium and one new 5.8S-ITS-RFLP profile are described. Species of non-Saccharomyces, predominantly H. opuntiae, were found in early stages of fermentation. Subsequently, S. cerevisiae prevailed followed by large numbers of P. kudriavzevii that dominated at the end of fermentations. Six native genotypes of S. cerevisiae were determined by interdelta sequence analysis. Genotypes III and IV were predominant. As a first step in exploring untapped yeast resources of the region, this study is important for monitoring the yeast ecology in native fermentations and screening indigenous yeasts that will produce wines with regional characteristics.

  7. Tartaric acid pathways in Vitis vinifera L. (cv. Ugni blanc): a comparative study of two vintages with contrasted climatic conditions.

    PubMed

    Cholet, Céline; Claverol, Stéphane; Claisse, Olivier; Rabot, Amélie; Osowsky, Audrey; Dumot, Vincent; Ferrari, Gerald; Gény, Laurence

    2016-06-28

    The acid component of grape berries, originating in the metabolism of malate and tartrate, the latter being less well-known than the former, is a key factor at play in the microbiological stability of wines destined for distillation. Grape acidity is increasingly affected by climate changes. The ability to compare two vintages with contrasted climatic conditions may contribute to a global understanding of the regulation of acid metabolism and the future consequences for berry composition. The results of the analyses (molecular, protein, enzymatic) of tartrate biosynthesis pathways were compared with the developmental accumulation of tartrate in Ugni blanc grape berries, from floral bud to maturity. The existence of two distinct steps during this pathway was confirmed: one prior to ascorbate, with phases of VvGME, VvVTC2, VvVTC4, VvL-GalDH, VvGLDH gene expression and abundant protein, different for each vintage; the other downstream of ascorbate, leading to the synthesis of tartrate with maximum VvL-IdnDH genetic and protein expression towards the beginning of the growth process, and in correlation with enzyme activity regardless of the vintage. Overall results suggest that the two steps of this pathway do not appear to be regulated in the same way and could both be activated very early on during berry development.

  8. Women in physics in France

    SciTech Connect

    Pierron-Bohnes, Véronique

    2015-12-31

    We present six associations and entities working in France on issues of women in physics: the Women and Physics Commission, French Physical Society; Women in Nuclear (WiN) France; Women and Science Association; Mission for the Place of Women at CNRS; Parity, Diversity, and Women Network, CEA; and the Network of University Equality-Diversity Representatives.

  9. France acts on electronic cigarettes.

    PubMed

    Cahn, Zachary

    2013-11-01

    France is deciding how to regulate electronic cigarettes. I first consider the French approach and how it contrasts with other attempts at electronic cigarette regulation globally. Next, I critique the individual elements of the French proposal. The overall approach taken by France is a positive development, but banning indoor use appears unnecessary and banning advertising may be counterproductive.

  10. ASTER Images Mt. Usu Volcano

    NASA Technical Reports Server (NTRS)

    2000-01-01

    On April 3, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra Satellite captured this image of the erupting Mt. Usu volcano in Hokkaido, Japan. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER will image the Earth for the next 6 years to map and monitor the changing surface of our planet.

    This false color infrared image of Mt Usu volcano is dominated by Lake Toya, an ancient volcanic caldera. On the south shore is the active Usu volcano. On Friday, March 31, more than 11,000 people were evacuated by helicopter, truck and boat from the foot of Usu, that began erupting from the northwest flank, shooting debris and plumes of smoke streaked with blue lightning thousands of feet in the air. Although no lava gushed from the mountain, rocks and ash continued to fall after the eruption. The region was shaken by thousands of tremors before the eruption. People said they could taste grit from the ash that was spewed as high as 2,700 meters (8,850 ft) into the sky and fell to coat surrounding towns with ash. 'Mount Usu has had seven significant eruptions that we know of, and at no time has it ended quickly with only a small scale eruption,' said Yoshio Katsui, a professor at Hokkaido University. This was the seventh major eruption of Mount Usu in the past 300 years. Fifty people died when the volcano erupted in 1822, its worst known eruption.

    In the image, most of the land is covered by snow. Vegetation, appearing red in the false color composite, can be seen in the agricultural fields, and forests in the mountains. Mt. Usu is crossed by three dark streaks. These are the paths of ash deposits that rained out from eruption plumes two days earlier. The prevailing wind was from the northwest, carrying the ash away from the main city of Date. Ash deposited can be traced on the image as far away as 10 kilometers (16

  11. ASTER Images Mt. Usu Volcano

    NASA Technical Reports Server (NTRS)

    2000-01-01

    On April 3, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra Satellite captured this image of the erupting Mt. Usu volcano in Hokkaido, Japan. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER will image the Earth for the next 6 years to map and monitor the changing surface of our planet.

    This false color infrared image of Mt Usu volcano is dominated by Lake Toya, an ancient volcanic caldera. On the south shore is the active Usu volcano. On Friday, March 31, more than 11,000 people were evacuated by helicopter, truck and boat from the foot of Usu, that began erupting from the northwest flank, shooting debris and plumes of smoke streaked with blue lightning thousands of feet in the air. Although no lava gushed from the mountain, rocks and ash continued to fall after the eruption. The region was shaken by thousands of tremors before the eruption. People said they could taste grit from the ash that was spewed as high as 2,700 meters (8,850 ft) into the sky and fell to coat surrounding towns with ash. 'Mount Usu has had seven significant eruptions that we know of, and at no time has it ended quickly with only a small scale eruption,' said Yoshio Katsui, a professor at Hokkaido University. This was the seventh major eruption of Mount Usu in the past 300 years. Fifty people died when the volcano erupted in 1822, its worst known eruption.

    In the image, most of the land is covered by snow. Vegetation, appearing red in the false color composite, can be seen in the agricultural fields, and forests in the mountains. Mt. Usu is crossed by three dark streaks. These are the paths of ash deposits that rained out from eruption plumes two days earlier. The prevailing wind was from the northwest, carrying the ash away from the main city of Date. Ash deposited can be traced on the image as far away as 10 kilometers (16

  12. The role of MT2-MMP in cancer progression

    SciTech Connect

    Ito, Emiko; Yana, Ikuo; Fujita, Chisato; Irifune, Aiko; Takeda, Maki; Madachi, Ayako; Mori, Seiji; Hamada, Yoshinosuke; Kawaguchi, Naomasa; Matsuura, Nariaki

    2010-03-05

    The role of MT2-MMP in cancer progression remains to be elucidated in spite of many reports on MT1-MMP. Using a human fibrosarcoma cell, HT1080 and a human gastric cancer cell, TMK-1, endogenous expression of MT1-MMP or MT2-MMP was suppressed by siRNA induction to examine the influence of cancer progression in vitro and in vivo. In HT1080 cells, positive both in MT1-MMP and MT2-MMP, the migration as well as the invasion was impaired by MT1-MMP or MT2-MMP suppression. Also cell proliferation in three dimensional (3D) condition was inhibited by MT1-MMP or MT2-MMP suppression and tumor growth in the nude mice transplanted with tumor cells were reduced either MT1-MMP or MT2-MMP suppression with a prolongation of survival time in vivo. MT2-MMP suppression induces more inhibitory effects on 3D proliferation and in vivo tumor growth than MT1-MMP. On the other hand, TMK-1 cells, negative in MT1-MMP and MMP-2 but positive in MT2-MMP, all the migratory, invasive, and 3D proliferative activities in TMK-1 are decreased only by MT2-MMP suppression. These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP independently of MMP-2 and MT1-MMP.

  13. Mt. Pinatubo, Phillippines - Perspective View

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The effects of the June 15, 1991, eruption of Mt. Pinatubo continue to affect the lives of people living near the volcano on the island of Luzon in the Philippines. The eruption produced a large amount of volcanic debris that was deposited on the flanks of the volcano as part of pyroclastic flows. This perspective view looking toward the east shows the western flank of the volcano where most of these pyroclastic flows were deposited.

    This debris consists of ash and boulders that mix with water after heavy rains to form volcanic mudflows called lahars. Lahars are moving rivers of concrete slurry that are highly erosive. They can sweep down existing river valleys, carving deep canyons where the slopes are steep, or depositing a mixture of fine ash and larger rocks on the gentler slopes. The deposits left from a lahar soon solidify into a material similar to concrete, but while they are moving, lahars are dynamic features, and in a single river valley the active channel may change locations within a few minutes or hours. These changes represent a significant natural hazard to local communities.

    The topographic data were collected by NASA's airborne imaging radar AIRSAR instrument on November 29, 1996. Colors are from the French SPOT satellite imaging data in both visible and infrared wavelengths collected in February 1996. Areas of vegetation appear red and areas without vegetation appear light blue. River valleys radiate out from the summit of the volcano (upper center). Since the eruption, lahars have stripped these valleys of any vegetation. The Pasig-Potrero River flows to the northeast off the summit in the upper right of the image.

    Scientists have been using airborne radar data collected by the AIRSAR instrument in their studies of the aftereffects of the Mt. Pinatubo eruption. AIRSAR collected imaging radar data over the volcano during a mission to the Pacific Rim region in late 1996 and on a follow-up mission to the area in late 2000. These data sets

  14. Metallothionein (MT) 1/2 expression in MT 1/2 and MT 3 knock-out mice and Long-Evans Cinnamon (LEC) rats.

    PubMed

    Nakazato, Kyoumi; Nakajima, Katsuyuki; Nakano, Takamitsu; Kodaira, Tsukasa; Nakayama, Kenji; Satoh, Masahiko; Nagamine, Takeaki

    2012-02-01

    Metallothionein (MT) is known to be involved in various physiological roles and diseases. However, a standard method for MT measurement has not been established until recently. Therefore, we have developed an easy and specific enzyme-linked immunosorbent assays (ELISA) to determine MT-1 and MT-2. In order to evaluate the method we developed, MT-1/2 in liver, kidney and brain was determined in wild type (WT), MT-1/2 knockout (KO) and MT-3 KO mice, with and without Cd treatment. MT 1/2 in urine was determined in genetically disordered LEC rats (an animal model of Wilson disease). MT-1/2 concentrations in the liver, kidney and brain in MT-1/2 KO mice were significantly lower compared to those of WT and MT-3 KO mice. MT-1/2 concentrations in the livers of WT mice significantly increased with Cd administration, but not in MT-1/2 KO mice. Similar results were observed by immunohistochemical staining. To confirm the molecular weight (MW) of MT detected in organs by the ELISA, analysis with a Sephadex G-75 was performed. Two peaks of MT-1/2 (MW small and large) were detected in WT and MT-3 KO mice. The small MT peak was mostly depleted in MT 1/2-KO mice, while a large MT peak remained. A significant increase in MT-1/2 concentration was detected in the urine of LEC rats with age and especially at the hepatitis stage. In conclusion, MT-1/2 ELISA and immunohistochemical staining was highly correlated with MT-1/2 determination in experimental animal specimens and could be a robust analytical tool for physiological and toxicological studies.

  15. Chronic erosion in Wissant Bay coast, northern France - Causes and trials of management projects

    NASA Astrophysics Data System (ADS)

    Sedrati, M.; Anthony, E. J.

    2012-04-01

    Cape Gris Nez to the southwest and Cape Blanc Nez to the northeast limit's Wissant Bay. This extreme northern coast of France, facing the Dover Strait, is one of the most rapidly eroding sector of coast in France. Shoreline retreat has exceeded 250 m in the last fifty years in the central and western parts of the bay, while the eastern sector of the bay is now a zone of accretion, after being a sand-starved zone in the past, when the western sector was either stable or in accretion. The reasons for these changes are still not clear. They seem to involve interactions between a nearshore sand bank and the activity of current gyres related to the projecting headland of Cape Gris Nez, beach rotation processes and human activities, notably past aggregate extraction from the nearshore sand bank which acted hitherto as both a dissipater of incident storm wave energy and as a coastal sand source. The aim of this paper to contribute to the understanding of these long-term changes and investigate the mechanisms of this mildly embayed coast evolution. To this end, 10-years of topographic profile data throughout the bay were analysed and confronted with offshore wave data. This analysis complements a previous analytical effort that determined gross rates of annual shoreline retreat by time slices of several decades from the careful interpretation of long series of ortho-rectified aerial photographs. The overall data suggest chronic sand bleeding from the western sector of the beach and longshore transport to the east, within a framework of what appears to be an ongoing beach rotation process within a dominant longshore sediment transport cell between the headland of Cape Gris Nez and the bold chalk cliffs of Cape Blanc Nez. Retreat of the beach-dune barrier in the western sector of Wissant Bay poses a threat in the coming years as there is a likelihood of storm breaching of the narrow dune barrier. Face to this critical situation, a proper management strategy involving a good

  16. Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors.

    PubMed

    Audinot, Valérie; Bonnaud, Anne; Grandcolas, Line; Rodriguez, Marianne; Nagel, Nadine; Galizzi, Jean-Pierre; Balik, Ales; Messager, Sophie; Hazlerigg, David G; Barrett, Perry; Delagrange, Philippe; Boutin, Jean A

    2008-05-15

    In order to interpret the effects of melatonin ligands in rats, we need to determine their activity at the receptor subtype level in the corresponding species. Thus, the rat melatonin rMT(1) receptor was cloned using DNA fragments for exon 1 and 2 amplified from rat genomic DNA followed by screening of a rat genomic library for the full length exon sequences. The rat rMT(2) receptor subtype was cloned in a similar manner with the exception of exon 1 which was identified by screening a rat genomic library with exon 1 of the human hMT(2) receptor. The coding region of these receptors translates proteins of 353 and 364 amino acids, respectively, for rMT(1) and rMT(2). A 55% homology was observed between both rat isoforms. The entire contiguous rat MT(1) and MT(2) receptor coding sequences were cloned, stably expressed in CHO cells and characterized in binding assay using 2-[(125)I]-Iodomelatonin. The dissociation constants (K(d)) for rMT(1) and rMT(2) were 42 and 130 pM, respectively. Chemically diverse compounds previously characterized at human MT(1) and MT(2) receptors were evaluated at rMT(1) and rMT(2) receptors, for their binding affinity and functionality in [(35)S]-GTPgammaS binding assay. Some, but not all, compounds shared a similar binding affinity and functionality at both rat and human corresponding subtypes. A different pharmacological profile of the MT(1) subtype has also been observed previously between human and ovine species. These in vitro results obtained with the rat melatonin receptors are thus of importance to understand the physiological roles of each subtype in animal models.

  17. Domain Tuning of Bilingual Lexicons for MT

    DTIC Science & Technology

    2003-02-01

    SUBTITLE Domain Tuning of Bilingual Lexicons for MT 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER...Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Domain Tuning of Bilingual Lexicons for MT Necip Fazıl Ayan, Bonnie J. Dorr, Okan Kolak...umiacs.umd.edu Domain Tuning of Bilingual Lexicons for MT Abstract Our overall objective is to translate a domain-specific document in a for- eign language (in

  18. Temporal Trends in Transcatheter Aortic Valve Replacement in France: FRANCE 2 to FRANCE TAVI.

    PubMed

    Auffret, Vincent; Lefevre, Thierry; Van Belle, Eric; Eltchaninoff, Hélène; Iung, Bernard; Koning, René; Motreff, Pascal; Leprince, Pascal; Verhoye, Jean Philippe; Manigold, Thibaut; Souteyrand, Geraud; Boulmier, Dominique; Joly, Patrick; Pinaud, Frédéric; Himbert, Dominique; Collet, Jean Philippe; Rioufol, Gilles; Ghostine, Said; Bar, Olivier; Dibie, Alain; Champagnac, Didier; Leroux, Lionel; Collet, Frédéric; Teiger, Emmanuel; Darremont, Olivier; Folliguet, Thierry; Leclercq, Florence; Lhermusier, Thibault; Olhmann, Patrick; Huret, Bruno; Lorgis, Luc; Drogoul, Laurent; Bertrand, Bernard; Spaulding, Christian; Quilliet, Laurent; Cuisset, Thomas; Delomez, Maxence; Beygui, Farzin; Claudel, Jean-Philippe; Hepp, Alain; Jegou, Arnaud; Gommeaux, Antoine; Mirode, Anfani; Christiaens, Luc; Christophe, Charles; Cassat, Claude; Metz, Damien; Mangin, Lionel; Isaaz, Karl; Jacquemin, Laurent; Guyon, Philippe; Pouillot, Christophe; Makowski, Serge; Bataille, Vincent; Rodés-Cabau, Josep; Gilard, Martine; Le Breton, Hervé

    2017-07-04

    Transcatheter aortic valve replacement (TAVR) is standard therapy for patients with severe aortic stenosis who are at high surgical risk. However, national data regarding procedural characteristics and clinical outcomes over time are limited. The aim of this study was to assess nationwide performance trends and clinical outcomes of TAVR during a 6-year period. TAVRs performed in 48 centers across France between January 2013 and December 2015 were prospectively included in the FRANCE TAVI (French Transcatheter Aortic Valve Implantation) registry. Findings were further compared with those reported from the FRANCE 2 (French Aortic National CoreValve and Edwards 2) registry, which captured all TAVRs performed from January 2010 to January 2012 across 34 centers. A total of 12,804 patients from FRANCE TAVI and 4,165 patients from FRANCE 2 were included in this analysis. The median age of patients was 84.6 years, and 49.7% were men. FRANCE TAVI participants were older but at lower surgical risk (median logistic European System for Cardiac Operative Risk Evaluation [EuroSCORE]: 15.0% vs. 18.4%; p < 0.001). More than 80% of patients in FRANCE TAVI underwent transfemoral TAVR. Transesophageal echocardiography guidance decreased from 60.7% to 32.3% of cases, whereas more recent procedures were increasingly performed in hybrid operating rooms (15.8% vs. 35.7%). Rates of Valve Academic Research Consortium-defined device success increased from 95.3% in FRANCE 2 to 96.8% in FRANCE TAVI (p < 0.001). In-hospital and 30-day mortality rates were 4.4% and 5.4%, respectively, in FRANCE TAVI compared with 8.2% and 10.1%, respectively, in FRANCE 2 (p < 0.001 for both). Stroke and potentially life-threatening complications, such as annulus rupture or aortic dissection, remained stable over time, whereas rates of cardiac tamponade and pacemaker implantation significantly increased. The FRANCE TAVI registry provided reassuring data regarding trends in TAVR performance in an all

  19. MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.

    PubMed

    Zlotos, Darius P; Jockers, Ralf; Cecon, Erika; Rivara, Silvia; Witt-Enderby, Paula A

    2014-04-24

    Numerous physiological functions of the pineal gland hormone melatonin are mediated via activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the market, ramelteon and agomelatine, as well as the most advanced drug candidates under clinical evaluation, tasimelteon and TIK-301, are high-affinity nonselective MT1/MT2 agonists. A great number of MT2-selective ligands and, more recently, several MT1-selective agents have been reported to date. Herein, we review recent advances in the field focusing on high-affinity agonists and antagonists and those displaying selectivity toward MT1 and MT2 receptors. Moreover, the existing models of MT1 and MT2 receptors as well as the current status in the emerging field of melatonin receptor oligomerization are critically discussed. In addition to the already existing indications, such as insomnia, circadian sleep disorders, and depression, new potential therapeutic applications of melatonergic ligands including cardiovascular regulation, appetite control, tumor growth inhibition, and neurodegenerative diseases are presented.

  20. [Nurse anesthetist in France].

    PubMed

    Mizuno, Ju; Yann, Douchy; De Almeida, Sylvie; Deckert, Christine; Gauss, Tobias; Bonneville, Claire Tae; Merckx, Paul; Mantz, Jean

    2006-12-01

    We present the system of nurse anesthetist (Infirmier Anesthésiste Diplômé d'Etat: IADE) in France to the community of Japanese anesthesiologists. This French system with 70 years' history is older than the Japan Society of Anesthesiologists itself. There are 7000 nurse anesthetists in France now and the number of nurse anesthetists increases by 450-500 each year. Training to become a nurse anesthetist requires at least two years' experience as a general nurse and the general nurse must pass an examination after two years' special training in an anesthetistic nurse school to acquire the national certification. The nurse anesthetist's profession is regulated by French law. They work in a team with certified anesthesiologists. They can perform many kinds of anesthetic tasks including tracheal intubation and insertion of arterial catheter under the responsibility and supervision of certified anesthesiologists. The nurse anesthetists are not allowed to perform spinal, epidural, conduction and local anesthesia, although they can maintain these anesthesia and control these methods, e.g., by injecting local anesthetic agents through epidural catheter, following a specified prescription. The nurse anesthetists are not allowed to insert central venous and pulmonary artery catheters, although they can manage them. They are allowed to administer inhalation anesthetic agents, and inject venous anesthetic agents, muscle relaxants, their antagonists, and opioids by their own initiatives, but the decision for the use of catecholamine and emergency drugs is reserved to certified anesthesiologists. The nurse anesthetists perform other tasks preparing and checking anesthetic agents and equipment such as anesthetic machine, monitor, and defibrillator everyday, and sometimes use autologous blood recovery systems. The relationship between the certified anesthesiologist and the nurse anesthetist is marked by mutual respect, confidence and cooperation at each step of the anesthetic

  1. World ethylene capacity tops 71 million mt/y; recovery on horizon

    SciTech Connect

    Rhodes, A.K.

    1994-04-25

    The Journal's survey of world ethylene capacity reveals a global total of more than 71 million metric tons/year (mt/y). The survey has been organized to provide additional data on feedstocks and plant ownership, where available. Where feedstock percentages were not provided by survey responders, an X'' indicates the feedstocks used, when known. Estimates of coproduct olefins production, such as propylene and butadiene, can be made based on feedstock composition. Table 1 shows ethylene capacities by global region. North America is the largest producer, followed by Western Europe and the Asia/Pacific region, where growth is strongest. Table 2 shows ethylene production totals by country. The top three producing countries are, in order, US, Japan, and Germany. Countries with 2 million mt/y or more capacity include Canada, France, The Netherlands, Saudi Arabia, Korea, Brazil, and China.

  2. Chemical and histochemical analysis of 'Quatre Saisons Blanc Mousseux', a Moss Rose of the Rosa x damascena group.

    PubMed

    Caissard, Jean-Claude; Bergougnoux, Véronique; Martin, Magali; Mauriat, Mélanie; Baudino, Sylvie

    2006-02-01

    Moss roses are old garden roses covered with a mossy growth on flower pedicel and calyx. This moss releases a pine-scented oleoresin that is very sticky and odoriferous. Rosa x centifolia 'muscosa' was the first moss rose to be obtained by bud-mutation but, interestingly, R. x damascena 'Quatre Saisons Blanc Mousseux' was the first repeat-blooming cultivar, thus interesting breeders. In the present study, the anatomy of these sports (i.e. bud-mutations) is characterized and the volatile organic compounds (VOCs) produced by the moss versus the petals are identified. They are compared between the two lines and their respective parents. Anatomy of the moss is studied by environmental scanning electron microscopy and histochemical light microscopy. Sudan Red IV and Fluorol Yellow 088 are used to detect lipids, and 1-naphthol reaction with N,N-dimethyl-p-phenylenediamine to detect terpenes (Nadi reaction). Head-space or solid/liquid extraction followed by gas chromatography and mass spectrometry are used to identify VOCs in moss, trichomes and petals. Moss of the two cultivars has the same structure with trichomes on other trichomes but not exactly the same VOCs. These VOCs are specific to the moss, with lots of terpenes. An identical VOC composition is found in leaves but not in petals. They are nearly the same in the moss mutants and in the respective wild types. Sepals of moss roses and their parents have a specific VOC pattern, different from that of the petals. The moss corresponds to a heterochronic mutation with trichomes developing on other trichomes. Such a mutation has probably appeared twice and independently in the two lines.

  3. Chemical and Histochemical Analysis of ‘Quatre Saisons Blanc Mousseux’, a Moss Rose of the Rosa × damascena Group

    PubMed Central

    CAISSARD, JEAN-CLAUDE; BERGOUGNOUX, VÉRONIQUE; MARTIN, MAGALI; MAURIAT, MÉLANIE; BAUDINO, SYLVIE

    2006-01-01

    • Background and Aims Moss roses are old garden roses covered with a mossy growth on flower pedicel and calyx. This moss releases a pine-scented oleoresin that is very sticky and odoriferous. Rosa × centifolia ‘muscosa’ was the first moss rose to be obtained by bud-mutation but, interestingly, R. × damascena ‘Quatre Saisons Blanc Mousseux’ was the first repeat-blooming cultivar, thus interesting breeders. In the present study, the anatomy of these sports (i.e. bud-mutations) is characterized and the volatile organic compounds (VOCs) produced by the moss versus the petals are identified. They are compared between the two lines and their respective parents. • Methods Anatomy of the moss is studied by environmental scanning electron microscopy and histochemical light microscopy. Sudan Red IV and Fluorol Yellow 088 are used to detect lipids, and 1-naphthol reaction with N,N-dimethyl-p-phenylenediamine to detect terpenes (Nadi reaction). Head-space or solid/liquid extraction followed by gas chromatography and mass spectrometry are used to identify VOCs in moss, trichomes and petals. • Key Results Moss of the two cultivars has the same structure with trichomes on other trichomes but not exactly the same VOCs. These VOCs are specific to the moss, with lots of terpenes. An identical VOC composition is found in leaves but not in petals. They are nearly the same in the moss mutants and in the respective wild types. • Conclusions Sepals of moss roses and their parents have a specific VOC pattern, different from that of the petals. The moss corresponds to a heterochronic mutation with trichomes developing on other trichomes. Such a mutation has probably appeared twice and independently in the two lines. PMID:16344264

  4. mtDNA analysis reveals a major late Paleolithic population expansion from southwestern to northeastern Europe.

    PubMed Central

    Torroni, A; Bandelt, H J; D'Urbano, L; Lahermo, P; Moral, P; Sellitto, D; Rengo, C; Forster, P; Savontaus, M L; Bonné-Tamir, B; Scozzari, R

    1998-01-01

    mtDNA sequence variation was studied in 419 individuals from nine Eurasian populations, by high-resolution RFLP analysis, and it was followed by sequencing of the control region of a subset of these mtDNAs and a detailed survey of previously published data from numerous other European populations. This analysis revealed that a major Paleolithic population expansion from the "Atlantic zone" (southwestern Europe) occurred 10,000-15,000 years ago, after the Last Glacial Maximum. As an mtDNA marker for this expansion we identified haplogroup V, an autochthonous European haplogroup, which most likely originated in the northern Iberian peninsula or southwestern France at about the time of the Younger Dryas. Its sister haplogroup, H, which is distributed throughout the entire range of Caucasoid populations and which originated in the Near East approximately 25,000-30,000 years ago, also took part in this expansion, thus rendering it by far the most frequent (40%-60%) haplogroup in western Europe. Subsequent migrations after the Younger Dryas eventually carried those "Atlantic" mtDNAs into central and northern Europe. This scenario, already implied by archaeological records, is given overwhelming support from both the distribution of the autochthonous European Y chromosome type 15, as detected by the probes 49a/f, and the synthetic maps of nuclear data. PMID:9545392

  5. Diatom ooze as weak layer for submarine mega-slides off Northwest Africa: Evidence from core-seismic integration in the Cap Blanc Slide area

    NASA Astrophysics Data System (ADS)

    Urlaub, Morelia; Geersen, Jacob; Krastel, Sebastian; Schwenk, Tilmann

    2017-04-01

    The continental slope off Northwest Africa has experienced at least four mega-landslides, each affecting over 20,000 km2 of seafloor. Although the landslides lie more than 400 km apart, they have many similar characteristics, including stepped headwall patterns and several bedding-parallel glide planes at slope angles of <2°. This morphology suggests that failures took place along multiple mechanically weak sedimentary layers that are present at different stratigraphic depths. From all Northwest African mega-landslides the Cap Blanc Slide, situated off the coasts of Mauretania and West Sahara, offers an unprecedented possibility to advance our understanding of landslide causes. ODP site 658 (Leg 108) was drilled within the evacuation area of the slide, recovering its glide plane. In addition, site 658 also recovered the glide plane and the overlying undisturbed sedimentary sequence of a younger slope failure, which took place within the evacuation are of the main Cap Blanc Slide at some distance to the borehole. We use core-seismic integration to characterize the glide planes as well as to determine the timing of slope failures. The sediments just above both glide planes have particularly high biogenic opal contents owing to the presence of large amounts of diatom microfossils. Diatoms are hollow structures of microfossil skeletons, which contain large amounts of bound and intraskeletal water. When a critical stress level is exceeded during compaction, the microfossil shells break. The stored water is released causing a sudden increase in pore pressure, which may facilitate slope failure. We therefore suggest that diatom oozes acted as weak layers in the case of the Cap Blanc Slide. Pronounced biogenic opal maxima occur during glacial terminations and are expected all along the Northwest African continental margin. We thus hypothesize that mega-slides off Northwest Africa, and potentially also at other continental margins, are preconditioned by episodically high

  6. Outreach in southern France

    SciTech Connect

    Jackson, D.

    1992-12-09

    France's Europort South community lives cheek by jowl with the chemical industry, with major complexes at For, Berre, and Lavera. Xavier Segond, technical adviser at the regional chemical industry association, Le Syndicat General des Industries Chimiques Provence-Alpes-Cote d'Azur Corse (SGIC), says a good relationship has grown over a period of 20 years. Segond describes Arco Chimie as an effective driving force for the Responsible Care effort in the region - partly because its US parent introduced the program on a worldwide basis in 1989, ahead of national industry association Union des Industries Chimiques (UIC; Paris). Arco's F2-billion ($373 million)/year Fos-sur-Mer site makes it a significant player. But in 1986 the company was a complete newcomer. We came to Fos as a US company, we had no Paris headquarters or French president, explains Dominique Lequeux, director/human resources. The community viewed the company with a mixture of curiosity and enthusiasm as a potential employer - about 330 people now work at the site. The day before the officials propylene oxide plant opening, we invited in local people, says Lequeux. That formed a good basis for its Responsible Care community outreach program. Now, schools, professional groups, and political groups make 20-25 plant visits each year.

  7. The "Casa" of Sevres, France.

    ERIC Educational Resources Information Center

    Waltuch, Margot

    1996-01-01

    Discusses the author's teaching experiences during the 1930s at "La Maison des Enfants," a Montessori school in Sevres, France. Provides photographs and descriptions of the school day, outdoor activities, gardening, cooking and eating, practical activities, and creative activities. (MDM)

  8. Volcanic records of the Laschamp geomagnetic excursion from Mt Ruapehu, New Zealand

    NASA Astrophysics Data System (ADS)

    Ingham, E.; Turner, G. M.; Conway, C. E.; Heslop, D.; Roberts, A. P.; Leonard, G.; Townsend, D.; Calvert, A.

    2017-08-01

    We present palaeodirectional records of the Laschamp geomagnetic excursion from lavas on Mt Ruapehu, New Zealand. Fourteen lava flows on the northwestern and southern flanks of Mt Ruapehu, with 40Ar/39Ar weighted mean plateau ages that range from 46.3 ± 2.0 to 39.9 ± 1.4 ka, were studied. The youngest and older flows carry a normal polarity magnetization; however, six flows, dated between 46.3 ± 2.0 and 42.7 ± 1.8 ka, record excursional directions. Three of these flows record southerly palaeomagnetic declinations and negative inclinations that agree well with a published Laschamp record from the Auckland Volcanic Field (AVF). Together, the AVF and Mt Ruapehu lavas currently represent the only volcanic records of the Laschamp excursion outside the Chaîne des Puys region, France. Thus, they make an important contribution to the global set of Laschamp excursion records. Virtual geomagnetic pole (VGP) groups for the New Zealand and French records early in the excursion are compatible with a dipole-dominated field that rotated to an equatorial orientation while simultaneously decaying in strength. In contrast, younger excursional flows from France and New Zealand yield separate VGP groups, which suggest either that the field had a nondipolar morphology in this later phase, or that the VGP groups were not synchronous. 40Ar/39Ar ages for the Mt Ruapehu record are on average slightly older than published northern hemisphere ages and from the relative palaeointensity minimum in the GLOPIS sedimentary stack. Although few individual ages differ significantly at the 2σ level, the spread suggests an overall excursion duration that is longer than the currently accepted 1500 years. This age spread may result from excess Ar in magmas at the time of the eruption biasing the results to slightly older ages, or from non-synchronous excursional field behaviour at near-antipodal locations, or, possibly, a precursory phase prior to the main excursion.

  9. 78 FR 44187 - Montana Disaster # MT-00079

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Montana Disaster MT-00079 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... have been determined to be adversely affected by the disaster: Primary Counties: Blaine,...

  10. Volcanic earthquake swarms at Mt. Erebus, Antarctica

    NASA Astrophysics Data System (ADS)

    Kaminuma, Katsutada; Ueki, Sadato; Juergen, Kienle

    1985-04-01

    Mount Erebus is an active volcano in Antarctica located on Ross Island. A convecting lava lake occupies the summit crater of Mt. Erebus. Since December 1980 the seismic activity of Mt. Erebus has been continuously monitored using a radio-telemetered network of six seismic stations. The seismic activity observed by the Ross Island network during the 1982-1983 field season shows that: (1)Strombolian eruptions occur frequently at the Erebus summit lava lake at rates of 2-5 per day; (2)centrally located earthquakes map out a nearly vertical, narrow conduit system beneath the lava lake; (3)there are other source regions of seismicity on Ross Island, well removed from Mt. Erebus proper. An intense earthquake swarm recorded in October 1982 near Abbott Peak, 10 km northwest of the summit of Mt. Erebus, and volcanic tremor accompanying the swarm, may have been associated with new dike emplacement at depth.

  11. Correlations of low-energy pulses and muons recorded by the LSD detector near Mont Blanc from February 10 to July 1, 1987

    NASA Astrophysics Data System (ADS)

    Dadykin, V. L.; Zatsepin, G. T.; Korol'Kova, E. V.; Korchagin, P. V.; Kudriavtsev, V. A.

    1991-04-01

    Observation data obtained by the LSD underground detector near Mont Blanc over the period February 10 - July 1, 1987, are analyzed for possible time correlations between all events with an energy over 5 MeV detected during this period. Nine pairs of correlated pulses (muons and low-energy pulses with a time interval of 2 s) are identified during the period from 5:42 to 10:13 UT on February 23, 1987 (i.e., around the time of the optical burst CH 1987A). The result indicates a possible relation between the time correlation of the pulses and the burst.

  12. SN1987A: correlation between the data recorded by the Mont Blanc neutrino detector and by the Maryland and Rome gravitational wave antennas.

    NASA Astrophysics Data System (ADS)

    Pallottino, G. V.

    The author reports the analysis of gravitational wave and neutrino detectors over a period of 18 hours that includes the Mont Blanc 5 neutrino burst time. There is statistical evidence for correlations during a period of about two hours, centered on the 5 neutrino burst: the effect is mainly due to a dozen of large amplitude Maryland and Rome events. The interpretation of these events as due to gravitational radiation from SN1987A should be rejected, according to the standard theory of the cross-section of g.w. detectors, since it would imply an emission of energy too large by a factor of about 104.

  13. Goldfish (Carassius auratus) matching geometric and featural cues: a reinterpretation of some of the data of Vargas, López, Salas, and Thinus-Blanc (2004).

    PubMed

    Cheng, Ken

    2005-11-01

    Vargas, López, Salas, and Thinus-Blanc showed that goldfish (Carassius auratus) can use both geometric and featural cues in relocating a target corner in a rectangular enclosure. When featural cues (arrangement of striped walls) were put in conflict with geometric cues, results differed according to target location during training. Vargas, López, et al. explained the results of their cue conflict in terms of 2 different strategies: mapping and cue guidance. I provide an alternative, more parsimonious interpretation in which the same strategy of attempting to match as many cues as possible applies to both cases.

  14. High morphogenic activity in the permafrost-affected rock walls of the Mont Blanc massif during the 2015 summer heat wave

    NASA Astrophysics Data System (ADS)

    Ravanel, Ludovic; Magnin, Florence; Deline, Philip

    2016-04-01

    In order to test the geomorphological hypothesis on the link between permafrost degradation and rock wall destabilisation, we survey all the rockfalls that occur in the central part of the Mont-Blanc massif using a network of observers since 2007. 511 rockfalls (100 < V < 45,000 m3) have been documented, year 2015 included. Between 2007 and 2014, the average number of destabilizations was 44 (from 17 in 2014 with a cold summer to 72 in 2009 with a relatively hot summer). In 2015, 160 events were recorded i.e. 4 times more than the annual average of the previous years. That makes the year 2015 similar to 2003 that was characterized by its summer heatwave triggering 152 rockfalls in the area currently covered by the network of observers, as shown by the analysis of a SPOT-5 image. Observations of 2015 are discussed and crossed with a statistical model of the Mean Annual Rock Surface Temperature (MARST) for the 1961-1990 period, implemented on a 4-m-resolution DEM of the Mont Blanc massif, and temperature measurements in three 10-m-deep boreholes at the Aiguille du Midi (3842 m a.s.l.), where the summer 2015 active layers have been the thickest since the start of measurements in 2009 (e.g. 3.6 m in the NE face against 2.9 m in average during the previous years). Before 2015, 90 % of the inventoried rockfalls occurred in areas where MARST is in the range -5 to 1°C, whereas only 50 % of the whole rock wall area above 2000 m a.s.l. covers this temperature range. With an air 0°C isotherm which sometimes exceeded the summit of Mont Blanc (4809 m a.s.l.) during the 2015 Summer, conditions were particularly unfavorable for mountaineering. Numerous rescues were carried out to climbers technically blocked by uncommon conditions or injured by rockfalls. On the normal route to the summit of Mont Blanc, two administrative closures of the Goûter hut (3835 m a.s.l.) were necessary to prevent climbers from the huge risk of rockfalls in the access couloir, known for its rockfall

  15. A surgical sabbatical in France.

    PubMed

    Sutherland, F; Launois, B

    2000-06-01

    During my stay in France I had the unique opportunity to meet surgical professors from all over the world and made many friends and contacts in the field of hepatobiliary surgery. Brittany is a beautiful province of France, having unique way of life and approach to social and societal problems. The cultural enrichment that I received from my year there will last a lifetime, as well the many fond memories of the people, the culinary delights and the spectacular seashore.

  16. Distant Mt. Fuji, Island of Honshu Japan

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This distant view of Mt. Fuji, on the main home island of Honshu, Japan (34.0N, 139.0E) was taken from about 450 miles to the south. Evan at that great distance, the majestic and inspiring Mt. Fuji is still plainly visible and easily recognized as a world renowned symbol of Japan. The snow capped extinct volcano lies just a few miles south of Tokyo.

  17. Distant Mt. Fuji, Island of Honshu Japan

    NASA Image and Video Library

    1992-11-01

    This distant view of Mt. Fuji, on the main home island of Honshu, Japan (34.0N, 139.0E) was taken from about 450 miles to the south. Evan at that great distance, the majestic and inspiring Mt. Fuji is still plainly visible and easily recognized as a world renowned symbol of Japan. The snow capped extinct volcano lies just a few miles south of Tokyo.

  18. The Italian drilling project of the Mont Blanc road tunnel in the late fifties: an example of no geological care and lack of ethics in carrying out a big work.

    NASA Astrophysics Data System (ADS)

    Gosso, Guido; Croce, Giuseppe; Matteucci, Ruggero; Peppoloni, Silvia; Piacente, Sandra; Wasowski, Janusz

    2013-04-01

    In the first decade after the Second World War Italy was rushing to recover a positive role among European countries; basic needs as road communications with European neighbours became main priorities. The necessity of a rapid connection with South-eastern France, a subject already debated between the two nations over more than 50 years, appeared then on first line; the two countries convened on a joint investment for the construction of a tunnel across the international border of Mont Blanc, along the shortest track between Courmayeur and Chamonix. The political agreements were in favour of the quickest start of the drilling operations and such obligation imposed on the Italian side an impoverishment of the project content, specially concerning geological issues. No surveys were performed on fracture systems, cataclastic zones and faults, on the few rock ridges standing above the tunnel line and outcropping through thick talus cones, moraines, ice tongues and their related ice plateaus. Metasediments, migmatites and poorly foliated granites were to be drilled. Three Italian academics were allowed by the drilling company to track the working progress and collect rocks for comparison with other Alpine types; they mapped the lithology and the fault zonesall along the freshly excavated tunnel; the results of such survey appeared after the end of works. Geologists from Florence University published the surface granite faulting pattern 20 years after the road tunnel became operative. Such geological cares could have located the risky zones in time for the tunnel project, mitigating the catastrophic effects of sudden drainage of subglacial water from the Vallée Blanche ice plateau (Ghiacciaio del Gigante) at progression 3800m, that caused dramatic accidents and affected negatively the economy of the drilling. Also the wallrock temperature drops, measured during the drill, should have warned the company management on the location of dangerous fracture zones. Anxiety of

  19. 77 FR 32896 - Modification of Class E Airspace; Billings, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ... airspace at Billings Logan International Airport, Billings, MT. Controlled airspace is necessary to... Billings, MT Billings Logan International Airport, MT (Lat. 45 48'28'' N., long. 108 32'34'' W.) That... Federal Aviation Administration 14 CFR Part 71 Modification of Class E Airspace; Billings, MT AGENCY...

  20. 44 CFR 15.3 - Access to Mt. Weather.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Access to Mt. Weather. 15.3... HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY TRAINING CENTER § 15.3 Access to Mt. Weather. Mt. Weather contains classified material and areas...

  1. 44 CFR 15.3 - Access to Mt. Weather.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Access to Mt. Weather. 15.3... HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY TRAINING CENTER § 15.3 Access to Mt. Weather. Mt. Weather contains classified material and areas...

  2. 44 CFR 15.3 - Access to Mt. Weather.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Access to Mt. Weather. 15.3... HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY TRAINING CENTER § 15.3 Access to Mt. Weather. Mt. Weather contains classified material and areas...

  3. 44 CFR 15.3 - Access to Mt. Weather.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Access to Mt. Weather. 15.3... HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY TRAINING CENTER § 15.3 Access to Mt. Weather. Mt. Weather contains classified material and areas...

  4. 44 CFR 15.3 - Access to Mt. Weather.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Access to Mt. Weather. 15.3... HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY TRAINING CENTER § 15.3 Access to Mt. Weather. Mt. Weather contains classified material and areas...

  5. Impact of oxygen dissolved at bottling and transmitted through closures on the composition and sensory properties of a Sauvignon Blanc wine during bottle storage.

    PubMed

    Lopes, Paulo; Silva, Maria A; Pons, Alexandre; Tominaga, Takatoshi; Lavigne, Valérie; Saucier, Cédric; Darriet, Philippe; Teissedre, Pierre-Louis; Dubourdieu, Denis

    2009-11-11

    This work outlines the results from an investigation to determine the effect of the oxygen dissolved at bottling and the specific oxygen barrier properties of commercially available closures on the composition, color and sensory properties of a Bordeaux Sauvignon Blanc wine during two years of storage. The importance of oxygen for wine development after bottling was also assessed using an airtight bottle ampule. Wines were assessed for the antioxidants (SO(2) and ascorbic acid), varietal thiols (4-mercapto-4-methylpentan-2-one, 3-mercaptohexan-1-ol), hydrogen sulfide and sotolon content, and color throughout 24 months of storage. In addition, the aroma and palate properties of wines were also assessed. The combination of oxygen dissolved at bottling and the oxygen transferred through closures has a significant effect on Sauvignon Blanc development after bottling. Wines highly exposed to oxygen at bottling and those sealed with a synthetic, Nomacorc classic closure, highly permeable to oxygen, were relatively oxidized in aroma, brown in color, and low in antioxidants and volatile compounds compared to wines sealed with other closures. Conversely, wines sealed under more airtight conditions, bottle ampule and screw cap Saran-tin, have the slowest rate of browning, and displayed the greatest contents of antioxidants and varietal thiols, but also high levels of H(2)S, which were responsible for the reduced dominating character found in these wines, while wines sealed with cork stoppers and screw cap Saranex presented negligible reduced and oxidized characters.

  6. Methoxypyrazine Accumulation and O-Methyltransferase Gene Expression in Sauvignon blanc Grapes: The Role of Leaf Removal, Light Exposure, and Berry Development.

    PubMed

    Gregan, Scott M; Jordan, Brian

    2016-03-23

    Methoxypyrazines are present in the grapes of certain Vitis vinifera varieties including Sauvignon blanc and contribute herbaceous/green aromas to wine. Environmental factors such as light exposure and temperature can influence methoxypyrazine levels, and viticultural interventions such as canopy manipulation have the ability to reduce methoxypyrazine accumulation in grapes. We assessed methoxypyrazine levels and showed that leaf removal significantly reduces accumulation in Sauvignon blanc grapes. The main effect of reducing methoxypyrazines was preveraison, as postveraison treatments had no effect on concentrations at harvest. Methoxypyrazine concentrations in controls peaked preveraison and decreased through harvest. Dilution due to an increase in berry weight was found to be the major driver of decreasing concentrations, as methoxypyrazine levels on a per berry basis were found to increase through development in two of three seasons. In the one year of our study that showed contrasting results, analyses of weather data indicate that warmer than average temperatures appear to be the principal factor affecting the berries' ability to accumulate and retain methoxypyrazines. We also explored the expression of potential biosynthetic O-methyltransferase genes VvOMT1, VvOMT2, and VvOMT3; no significant differences were observed with respect to effect of leaf removal and light exposure.

  7. Indications of the prominent role of elemental sulfur in the formation of the varietal thiol 3-mercaptohexanol in Sauvignon blanc wine.

    PubMed

    Araujo, Leandro Dias; Vannevel, Sebastian; Buica, Astrid; Callerot, Suzanne; Fedrizzi, Bruno; Kilmartin, Paul A; du Toit, Wessel J

    2017-08-01

    Elemental sulfur is a fungicide traditionally used to control Powdery Mildew in the production of grapes. The presence of sulfur residues in grape juice has been associated with increased production of hydrogen sulfide during fermentation, which could take part in the formation of the varietal thiol 3-mercaptohexanol. This work examines whether elemental sulfur additions to Sauvignon blanc juice can increase the levels of sought-after varietal thiols. Initial trials were performed in South Africa and indicated a positive impact of sulfur on the levels of thiols. Further experiments were then carried out with New Zealand Sauvignon blanc and confirmed a positive relationship between elemental sulfur additions and wine varietal thiols. The formation of hydrogen sulfide was observed when the addition of elemental sulfur was made to clarified juice, along with an increase in further reductive sulfur compounds. When the addition of sulfur was made to pressed juice, prior to clarification, the production of reductive sulfur compounds was drastically decreased. Some mechanistic considerations are also presented, involving the reduction of sulfur to hydrogen sulfide prior to fermentation. Copyright © 2016. Published by Elsevier Ltd.

  8. Thermal stability of thaumatin-like protein, chitinase, and invertase isolated from Sauvignon blanc and Semillon juice and their role in haze formation in wine.

    PubMed

    Falconer, Robert J; Marangon, Matteo; Van Sluyter, Steven C; Neilson, Karlie A; Chan, Cherrine; Waters, Elizabeth J

    2010-01-27

    A thermal unfolding study of thaumatin-like protein, chitinase, and invertase isolated from Vitis vinifera Sauvignon blanc and Semillon juice was undertaken. Differential scanning calorimetry demonstrated that chitinase was a major player in heat-induced haze in unfined wines as it had a low melt temperature, and aggregation was observed. The kinetics of chitinase F1 (Sauvignon blanc) unfolding was studied using circular dichroism spectrometry. Chitinase unfolding conforms to Arrhenius behavior having an activation energy of 320 kJ/mol. This enabled a predictive model for protein stability to be generated, predicting a half-life of 9 years at 15 degrees C, 4.7 days at 30 degrees C, and 17 min at 45 degrees C. Circular dichroism studies indicate that chitinase unfolding follows three steps: an initial irreversible step from the native to an unfolded conformation, a reversible step between a collapsed and an unfolded non-native conformation, followed by irreversible aggregation associated with visible haze formation.

  9. 25 years (1981-2005) of equilibrium-line altitude and mass-balance reconstruction on Glacier Blanc, French Alps, using remote-sensing methods and meteorological data

    NASA Astrophysics Data System (ADS)

    Rabatel, Antoine; Dedieu, Jean-Pierre; Thibert, Emmanuel; Letréguilly, Anne; Vincent, Christian

    Annual equilibrium-line altitude (ELA) and surface mass balance of Glacier Blanc, Ecrins region, French Alps, were reconstructed from a 25 year time series of satellite images (1981-2005). The remote-sensing method used was based on identification of the snowline, which is easy to discern on optical satellite images taken at the end of the ablation season. In addition, surface mass balances at the ELA were reconstructed for the same period using meteorological data from three nearby weather stations. A comparison of the two types of series reveals a correlation of r > 0.67 at the 0.01 level of significance. Furthermore, the surface mass balances obtained from remote-sensing data are consistent with those obtained from field measurements on five other French glaciers (r = 0.76, p < 0.01). Also consistent for Glacier Blanc is the total mass loss (10.8 m w.e.) over the studied period. However, the surface mass balances obtained with the remote-sensing method show lower interannual variability. Given that the remote-sensing method is based on changes in the ELA, this difference probably results from the lower sensitivity of the surface mass balance to climate parameters at the ELA.

  10. 3D Detection, Quantification and Correlation of Slope Failures with Geologic Structure in the Mont Blanc massif

    NASA Astrophysics Data System (ADS)

    Allan, Mark; Dunning, Stuart; Lim, Michael; Woodward, John

    2016-04-01

    A thorough understanding of supply from landslides and knowledge of their spatial distribution is of fundamental importance to high-mountain sediment budgets. Advances in 3D data acquisition techniques are heralding new opportunities to create high-resolution topographic models to aid our understanding of landscape change through time. In this study, we use a Structure-from-Motion Multi-View Stereo (SfM-MVS) approach to detect and quantify slope failures at selected sites in the Mont Blanc massif. Past and present glaciations along with its topographical characteristics have resulted in a high rate of geomorphological activity within the range. Data for SfM-MVS processing were captured across variable temporal scales to examine short-term (daily), seasonal and annual change from terrestrial, Unmanned Aerial Vehicle (UAV) and helicopter perspectives. Variable spatial scales were also examined ranging from small focussed slopes (~0.01 km2) to large valley-scale surveys (~3 km2). Alignment and registration were conducted using a series of Ground Control Points (GCPs) across the surveyed slope at various heights and slope aspects. GCPs were also used to optimise data and reduce non-linear distortions. 3D differencing was performed using a multiscale model-to-model comparison algorithm (M3C2) which uses variable thresholding across each slope based on local surface roughness and model alignment quality. Detected change was correlated with local slope structure and 3D discontinuity analysis was undertaken using a plane-detection and clustering approach (DSE). Computation of joint spacing was performed using the classified data and normal distances. Structural analysis allowed us to assign a Slope Mass Rating (SMR) and assess the stability of each slope relative to the detected change and determine likely failure modes. We demonstrate an entirely 3D workflow which preserves the complexity of alpine slope topography to compute volumetric loss using a variable threshold. A

  11. Rare earth and trace element mobility in mid-crustal shear zones: insights from the Mont Blanc Massif (Western Alps)

    NASA Astrophysics Data System (ADS)

    Rolland, Yann; Cox, Stephen; Boullier, Anne-Marie; Pennacchioni, Giorgio; Mancktelow, Neil

    2003-09-01

    The behaviour of rare earth elements (REE) during fluid-rock interaction in mid-crustal shear zones has received little attention, despite their potential for mass balance calculation and isotopic tracing during deformation. In this study, several cases of large REE mobility during Alpine fluid-driven shear zone development in the pre-Alpine granitic basement of the Mont Blanc Massif are considered. On a regional scale, the undeformed granite compositions range within 5 wt% SiO 2 (70.5-75.3 wt%) and magmatic chemical variations are of the order of 10-20%, ascribed to minor effects of crystal fractionation. Major and trace element mobility observed in shear zones largely exceeds these initial variations. Shear zones developed a range of mineral assemblages as a result of shearing at mid-crustal depths (at ˜0.5 GPa, 400°C). Five main shear zone assemblages involve muscovite, chlorite, epidote, actinolite and calcite, respectively, as major phases. In most cases, selective enrichments of light or heavy REE (and Y, Ta, Hf) are observed. REE mobility is unrelated to deformation style (cataclastic, mylonitic), the intensity of strain, and to the shear zone's major metamorphic mineral assemblages. Instead, the changes in REE concentrations are ascribed to the alteration of pre-existing magmatic REE-bearing minerals during deformation-related fluid-rock interaction and to the syntectonic precipitation of metamorphic REE-bearing minerals (mainly monazite, bastnäsite, aeschynite and tombarthite). Minor proportions (<2%) of these accessory phases, with grain sizes mostly <20 μm, account for enrichments of up to 5:1 compared to the initial granite whole-rock REE budget. The stability of the REE phases appears to be largely dependent on the altering fluid composition. REE mobility is ascribed to changes in pH and to the availability of CO 32-, PO 42-, and SO 42-ligands in the fluid. Such processes are likely to influence the mobility of REE, Y, Hf and Ta in shear zones.

  12. Rockfalls on steep rock walls in the Mont Blanc massif: a statistical approach for the 2007 and 2008 events

    NASA Astrophysics Data System (ADS)

    Ravanel, L.; Allignol, F.; Deline, P.; Ravello, M.

    2009-04-01

    It is hypothesized that climatic warming since 1980 increases rock wall instability in high mountains due to permafrost degradation. This is supported by the observation of ice in several rockfall scars. Due to a lack of systematic observations, magnitude and frequency of high mountain rock failures remain poorly known. As a part of the French-Italian PERMAdataROC project (2005-2008) and the EU-funded transalpine PermaNET project (2008-2011), we developed a present-day rockfall database. It contains information collected during systematic surveys carried out by local people (mountain guides, hut keepers, researchers). Although difficult to implement, this approach seems an efficient way to systematically record slope instability events of all sizes related to climate variations. The database compiles the characteristics (topography, volume, scar geometry, deposit) of the 44 and the 20 rockfalls observed in 2007 and 2008, respectively, in the Mont-Blanc massif (Swiss and Saint-Gervais sides excepted). For each event, scar elevation, slope angle and aspect of the affected slopes are issues from ArcGIS, using a 50 m digital elevation model (DEM) - enhanced to 10 m for affected areas - for the French side of the massif, and a 10 m DEM for the Italian side. Among the 64 documented rockfalls, 53 occurred at an altitude above 3000 m a.s.l (but none above 3900 m), on slopes with an angle mainly in the range 50-60°. Massive ice has been directly observed in 12 scars. The four largest rockfalls occurred on the steepest, Italian side at: Dent de Jetoula (at 2810 m a.s.l.; 15,000 m3) on August 2007, one of the lowest in altitude; Tour des Grandes Jorasses (at 3830 m; 10,000 m3) on September 2007; Aiguilles de Thoules (at 3450 m; 8,000 m3) on July 2008; and Tré-la-Tête (at 3470 m; 50,000 m3) on September 2008. Detailed results are presented, statistically analysed and normalized.

  13. Beginning of Viniculture in France

    NASA Technical Reports Server (NTRS)

    McGovern, Patrick E.; Luley, Benjamin P.; Rovira, Nuria; Mirzoian, Armen; Callahan, Michael P.; Smith, Karen E.; Hall, Gretchen R.; Davidson, Theodore; Davidson, Theodore

    2013-01-01

    Chemical analyses of ancient organic compounds absorbed into the pottery fabrics of imported Etruscan amphoras (ca. 500-475 B.C.) and into a limestone pressing platform (ca. 425-400 B.C.) at the ancient coastal port site of Lattara in southern France provide the earliest biomolecular archaeological evidence for grape wine and viniculture from this country, which is crucial to the later history of wine in Europe and the rest of the world. The data support the hypothesis that export of wine by ship from Etruria in central Italy to southern Mediterranean France fueled an ever-growing market and interest in wine there, which, in turn, as evidenced by the winepress, led to transplantation of the Eurasian grapevine and the beginning of a Celtic industry in France. Herbal and pine resin additives to the Etruscan wine point to the medicinal role of wine in antiquity, as well as a means of preserving it during marine transport.

  14. Beginning of Viniculture in France

    NASA Technical Reports Server (NTRS)

    McGovern, Patrick E.; Luley, Benjamin P.; Rovira, Nuria; Mirzoian, Armen; Callahan, Michael P.; Smith, Karen F.; Hall, Gretchen R.; Davidson, Theodore; Henkin, Joshua M.

    2013-01-01

    Chemical analyses of ancient organic compounds absorbed into the pottery fabrics of imported Etruscan amphoras (ca. 500-475 B.C.) and into a limestone pressing platform (ca. 425-400 B.C.) at the ancient coastal port site of Lattara in southern France provide the earliest biomolecular archaeological evidence for grape wine and viniculture from this country, which is crucial to the later history of wine in Europe and the rest of the world. The data support the hypothesis that export of wine by ship from Etruria in central Italy to southern Mediterranean France fueled an ever-growing market and interest in wine there, which, in turn, as evidenced by the winepress, led to transplantation of the Eurasian grapevine and the beginning of a Celtic industry in France. Herbal and pine resin additives to the Etruscan wine point to the medicinal role of wine in antiquity, as well as a means of preserving it during marine transport.

  15. Beginning of viniculture in France.

    PubMed

    McGovern, Patrick E; Luley, Benjamin P; Rovira, Nuria; Mirzoian, Armen; Callahan, Michael P; Smith, Karen E; Hall, Gretchen R; Davidson, Theodore; Henkin, Joshua M

    2013-06-18

    Chemical analyses of ancient organic compounds absorbed into the pottery fabrics of imported Etruscan amphoras (ca. 500-475 B.C.) and into a limestone pressing platform (ca. 425-400 B.C.) at the ancient coastal port site of Lattara in southern France provide the earliest biomolecular archaeological evidence for grape wine and viniculture from this country, which is crucial to the later history of wine in Europe and the rest of the world. The data support the hypothesis that export of wine by ship from Etruria in central Italy to southern Mediterranean France fueled an ever-growing market and interest in wine there, which, in turn, as evidenced by the winepress, led to transplantation of the Eurasian grapevine and the beginning of a Celtic industry in France. Herbal and pine resin additives to the Etruscan wine point to the medicinal role of wine in antiquity, as well as a means of preserving it during marine transport.

  16. Earthworm Lumbricus rubellus MT-2: Metal Binding and Protein Folding of a True Cadmium-MT

    PubMed Central

    Kowald, Gregory R.; Stürzenbaum, Stephen R.; Blindauer, Claudia A.

    2016-01-01

    Earthworms express, as most animals, metallothioneins (MTs)—small, cysteine-rich proteins that bind d10 metal ions (Zn(II), Cd(II), or Cu(I)) in clusters. Three MT homologues are known for Lumbricus rubellus, the common red earthworm, one of which, wMT-2, is strongly induced by exposure of worms to cadmium. This study concerns composition, metal binding affinity and metal-dependent protein folding of wMT-2 expressed recombinantly and purified in the presence of Cd(II) and Zn(II). Crucially, whilst a single Cd7wMT-2 species was isolated from wMT-2-expressing E. coli cultures supplemented with Cd(II), expressions in the presence of Zn(II) yielded mixtures. The average affinities of wMT-2 determined for either Cd(II) or Zn(II) are both within normal ranges for MTs; hence, differential behaviour cannot be explained on the basis of overall affinity. Therefore, the protein folding properties of Cd- and Zn-wMT-2 were compared by 1H NMR spectroscopy. This comparison revealed that the protein fold is better defined in the presence of cadmium than in the presence of zinc. These differences in folding and dynamics may be at the root of the differential behaviour of the cadmium- and zinc-bound protein in vitro, and may ultimately also help in distinguishing zinc and cadmium in the earthworm in vivo. PMID:26742040

  17. Earthworm Lumbricus rubellus MT-2: Metal Binding and Protein Folding of a True Cadmium-MT.

    PubMed

    Kowald, Gregory R; Stürzenbaum, Stephen R; Blindauer, Claudia A

    2016-01-05

    Earthworms express, as most animals, metallothioneins (MTs)-small, cysteine-rich proteins that bind d(10) metal ions (Zn(II), Cd(II), or Cu(I)) in clusters. Three MT homologues are known for Lumbricus rubellus, the common red earthworm, one of which, wMT-2, is strongly induced by exposure of worms to cadmium. This study concerns composition, metal binding affinity and metal-dependent protein folding of wMT-2 expressed recombinantly and purified in the presence of Cd(II) and Zn(II). Crucially, whilst a single Cd₇wMT-2 species was isolated from wMT-2-expressing E. coli cultures supplemented with Cd(II), expressions in the presence of Zn(II) yielded mixtures. The average affinities of wMT-2 determined for either Cd(II) or Zn(II) are both within normal ranges for MTs; hence, differential behaviour cannot be explained on the basis of overall affinity. Therefore, the protein folding properties of Cd- and Zn-wMT-2 were compared by ¹H NMR spectroscopy. This comparison revealed that the protein fold is better defined in the presence of cadmium than in the presence of zinc. These differences in folding and dynamics may be at the root of the differential behaviour of the cadmium- and zinc-bound protein in vitro, and may ultimately also help in distinguishing zinc and cadmium in the earthworm in vivo.

  18. Pyemotes ventricosus Dermatitis, Southeastern France

    PubMed Central

    Blanc-Amrane, Véronique; Bahadoran, Philippe; Caumes, Eric; Marty, Pierre; Lazar, Mariléna; Boissy, Christian; Desruelles, François; Izri, Arezki; Ortonne, Jean-Paul; Counillon, Evelyne; Chosidow, Olivier; Delaunay, Pascal

    2008-01-01

    We investigated 42 patients who had unusual pruritic dermatitis associated with a specific clinical sign (comet sign) in 23 houses in southeastern France from May through September 2007. Pyemotes ventricosus, a parasite of the furniture beetle Anobium punctatum, was the cause of this condition. PMID:18976564

  19. Pyemotes ventricosus dermatitis, southeastern France.

    PubMed

    Del Giudice, Pascal; Blanc-Amrane, Véronique; Bahadoran, Philippe; Caumes, Eric; Marty, Pierre; Lazar, Mariléna; Boissy, Christian; Desruelles, François; Izri, Arezki; Ortonne, Jean-Paul; Counillon, Evelyne; Chosidow, Olivier; Delaunay, Pascal

    2008-11-01

    We investigated 42 patients who had unusual pruritic dermatitis associated with a specific clinical sign (comet sign) in 23 houses in southeastern France from May through September 2007. Pyemotes ventricosus, a parasite of the furniture beetle Anobium punctatum, was the cause of this condition.

  20. Education in France: Number 41.

    ERIC Educational Resources Information Center

    French Embassy, New York, NY. French Cultural Services.

    The history and modernization of the French nursery and elementary schools are the focal points of this review of educational trends in France. One major section discussed the "Ecole Maternelle", kindergarten, nursery schools, the "Jardin d'Enfants", and new math. Another section treats: (1) "Les Ecoles Primaires",…

  1. 77 FR 48198 - Montana Disaster #MT-00068

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... ADMINISTRATION Montana Disaster MT-00068 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of Montana dated 08/06/2012. Incident: Dahl Fire. Incident Period: 06/26/2012 through 07/06/2012. Effective Date: 08/06/2012...

  2. 77 FR 47907 - Montana Disaster #MT-00067

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... ADMINISTRATION Montana Disaster MT-00067 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of MONTANA dated 08/02/2012. Incident: Ash Creek Fire. Incident Period: 06/25/2012 through 07/22/2012. Effective Date: 08/02...

  3. "Climbing" Mt. Everest with IMAX Cinematographers.

    ERIC Educational Resources Information Center

    Ferguson, Nancy P.

    1997-01-01

    Describes how an elementary school teacher incorporated the real-life experiences of an IMAX (Image-Maximum) photography expedition to Mt. Everest into her curriculum. Highlights include geography lessons, math and problem solving, science-related issues, Tibetan Buddhism, and constructing a World Wide Web site. (LRW)

  4. 75 FR 39277 - Sorbitol From France; Determination

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... COMMISSION Sorbitol From France; Determination On the basis of the record \\1\\ developed in the subject five... antidumping duty order on sorbitol from France, would not be likely to lead to continuation or recurrence of...), entitled Sorbitol from France (Inv. No. 731-TA-44 (Third Review). \\2\\ The Commission determined to exercise...

  5. Geomatics techniques applied to time series of aerial images for multitemporal geomorphological analysis of the Miage Glacier (Mont Blanc).

    NASA Astrophysics Data System (ADS)

    Perotti, Luigi; Carletti, Roberto; Giardino, Marco; Mortara, Giovanni

    2010-05-01

    The Miage glacier is the major one in the Italian side of the Mont Blanc Massif, the third by area and the first by longitudinal extent among Italian glaciers. It is a typical debris covered glacier, since the end of the L.I.A. The debris coverage reduces ablation, allowing a relative stability of the glacier terminus, which is characterized by a wide and articulated moraine apparatus. For its conservative landforms, the Miage Glacier has a great importance for the analysis of the geomorphological response to recent climatic changes. Thanks to an organized existing archive of multitemporal aerial images (1935 to present) a photogrammetric approach has been applied to detect recent geomorphological changes in the Miage glacial basin. The research team provided: a) to digitize all the available images (still in analogic form) through photogrammetric scanners (very low image distortions devices) taking care of correctly defining the resolution of the acquisition compared to the scale mapping images are suitable for; b) to import digitized images into an appropriate digital photogrammetry software environment; c) to manage images in order, where possible, to carried out the stereo models orientation necessary for 3D navigation and plotting of critical geometric features of the glacier. Recognized geometric feature, referring to different periods, can be transferred to vector layers and imported in a GIS for further comparisons and investigations; d) to produce multi-temporal Digital Elevation Models for glacier volume changes; e) to perform orthoprojection of such images to obtain multitemporal orthoimages useful for areal an planar terrain evaluation and thematic analysis; f) to evaluate both planimetric positioning and height determination accuracies reachable through the photogrammetric process. Users have to known reliability of the measures they can do over such products. This can drive them to define the applicable field of this approach and this can help them to

  6. Surface exposure dating with cosmogenic 10Be of Late Holocene rock avalanches onto glaciers in the Mont Blanc massif, Italy

    NASA Astrophysics Data System (ADS)

    Deline, Philip; Akçar, Naki; Ivy-Ochs, Susan; Kubik, Peter W.

    2013-04-01

    Rock avalanching represents a potential high risk for growing infrastructure and people living in high mountain areas. This hazardous process is due to steep slopes, high relief, intensive rock fracturing, seismicity, paraglacial control, periglacial climatic conditions and the presence and interaction of snow, glaciers, and permafrost. The timing of rock avalanche recurrence intervals and the recognition of their spatial extension are essential. Very steep and elevated slopes on the Italian flank of the Mont Blanc massif are prone to rock avalanches (RAs) which travel onto glaciers. Whereas small RAs occurred in the Glacier du Miage basin during the 20th Century (the latest in July 2012), large RAs (volume > 1 M m3) travelled repeatedly onto Glaciers de Triolet, Frébouge, and la Brenva during the late Holocene The nature of the granitic deposit which largely overlaps the bottom of the upper Val Ferret over 2 km has been discussed since the 19th century. This extensive deposit was attributed to either glacial, or a September 12th 1717 AD rock avalanche, or a complex mixture of glacial, earlier RA and 1717 RA origin. Surface exposure dating of 16 boulders of the deposit shows that the 1717 RA, covering the whole upper Ferret valley floor, was one of the largest late Holocene RAs of the Alps, with a rock volume of 10-15 M m3 and a likely similar volume of glacier ice travelling more than 7 km downvalley. Two main RA deposits are lying downstream of the Glacier de Frébouge: a sheet of granite boulders with an open-work structure covers the south side of the Val Ferret, which ran > 100 m up the opposite metasedimentary side of the valley; a smaller RA deposit is located at the south and east margins of the large Frébouge polygenic fan. Surface exposure dating of 7 granite boulders of these deposits could in particular confirm whether the larger RA occurred sometime between 991 and 1154 AD, as suggested by a radiocarbon-dated piece of wood. Large RAs (volume > 2 M m3

  7. Bruce Medalists at the Mt. Wilson Observatory

    NASA Astrophysics Data System (ADS)

    Tenn, J. S.

    2004-12-01

    The institution which succeeded the Mt. Wilson Station of Yerkes Observatory in 1904 has had six names and three sites. From 1948-1980 it was united with Caltech's Palomar Observatory, and since then its main observatory has been in Chile, though still headquartered on Santa Barbara Street in Pasadena. For more than half of the twentieth century it was the leading observatory in the world. One bit of evidence for this is the amazing number of its staff members awarded the Bruce Medal. The Catherine Wolfe Bruce Gold Medal of the Astronomical Society of the Pacific has been awarded for lifetime contributions to astronomy since 1898. It is an international award. It wasn't until 1963 that the number of medalists who had worked primarily in the United States reached half the total. Yet fourteen of the first 87 medalists spent most of their careers at Mt. Wilson, including the period when it was Mt. Wilson and Palomar, and another three were Caltech observers who used the telescopes of the jointly operated observatory. Several more medalists made substantial use of the telescopes on Mt. Wilson and Palomar Mountain. We will discuss highlights of the careers of a number of these distinguished astronomers: directors George Ellery Hale, Walter Adams, Ira Bowen, and Horace Babcock; solar observer and satellite discoverer Seth Nicholson; instrument builder Harold Babcock; galactic and cosmological observers Frederick Seares, Edwin Hubble, Walter Baade, Rudolph Minkowski, and Allan Sandage; and spectroscopists Paul Merrill, Alfred Joy, Olin Wilson, Jesse Greenstein, Maarten Schmidt, and Wallace Sargent. We will touch briefly on others who used Mt. Wilson and/or Palomar, including Harlow Shapley, Joel Stebbins, Charlotte Moore Sitterly, Donald Osterbrock, and Albert Whitford.

  8. Rock falls in high-alpine rock walls quantified by terrestrial lidar measurements: A case study in the Mont Blanc area

    NASA Astrophysics Data System (ADS)

    Rabatel, Antoine; Deline, Philip; Jaillet, Stéphane; Ravanel, Ludovic

    2008-05-01

    The global warming observed in recent decades and its future increase may affect permafrost distribution on high-mountain faces with consequences for their stability. In this paper, we show that rock falls from high-alpine rock walls can be computed with a decimetre-resolution using lidar measurements. A laser scanner was used to create point clouds and triangulated irregular network models on the east face of the Tour Ronde at 3792 m asl (Mont Blanc massif). Comparison of the models realised from measurements of July 2005 and July 2006 enabled quantification of rock falls with reduced uncertainty. The volume of rock fall reached a total of 536 m3 in the scanned area, which matches an erosion rate of 8.4 mm yr-1. This rate slightly higher to the ones reported in former studies enable to assume that this rock fall may be the consequence of the permafrost degradation in this rock face.

  9. Charm hadroproduction cross-section up to 100 TeV from measurements of the cosmic-ray muon angular distribution Results of the Mount Blanc experiment

    NASA Astrophysics Data System (ADS)

    Castellina, A.; Dettorre Piazzoli, B.; Mannocchi, G.; Picchi, P.; Vernetto, S.; Bilokon, H.

    1985-02-01

    Accurate calculations of the angular distributions of underground conventional and prompt muons have been performed. The dependence of the angular enhancement functions on the primary spectrum, cross-sections, inclusive distributions, K/pi ratio and survival probability have been studied and found to be negligible. The results have been used to interpret the data from the Mont Blanc experiment in the depth range 4200-5800 hg/sq cm. Since the measurements extend over a limited angular range (lesser than 60 deg) the ratio between the flux of prompt to conventional muons of higher energy (greater than 1 TeV) is obtained with large associated statistical errors. In order to obtain the charm production cross-section in the energy region 50-100 TeV, accurate measurements over a very large angular range (greater than 70 deg) at depths higher than 5000 hg/sq cm are required.

  10. Quantitation of selected terpenoids and mercaptans in the dual-purpose hop varieties Amarillo, Citra, Hallertau Blanc, Mosaic, and Sorachi Ace.

    PubMed

    Cibaka, Marie-Lucie Kankolongo; Gros, Jacques; Nizet, Sabrina; Collin, Sonia

    2015-03-25

    Free terpenoids and both free and bound polyfunctional thiols were investigated in five selected dual-purpose hop cultivars. Surprisingly, the dual-purpose Sorachi Ace variety was found to contain higher amounts of farnesene (2101 mg/kg) than aromatic hops such as Saaz but only traces of 3-methylbutylisobutyrate, a compound that usually distinguishes all bitter varieties. All five cultivars investigated here showed an exceptional citrus-like potential explained by either monoterpenic alcohols or polyfunctional thiols. Among the monoterpenic alcohols, β-citronellol at concentrations above 7 mg/kg distinguished Amarillo, Citra, Hallertau Blanc, Mosaic, and Sorachi Ace from Nelson Sauvin and Tomahawk, two previously investigated dual-purpose hops, while linalool (312 mg/kg) and geraniol (211 mg/kg) remained good discriminating compounds for Nelson Sauvin and Tomahawk, respectively. Regarding polyfunctional thiols, higher amounts of 3-sulfanylhexyl acetate (27 μg/kg) characterized the Citra variety. Free 4-sulfanyl-4-methylpentan-2-one proved discriminant for Sorachi Ace, while the bound form is predominant in Nelson Sauvin. On the other hand, an S-conjugate of 3-sulfanylhexan-1-ol was found in Sorachi Ace at levels not far from those previously reported for Cascade, although the free form was undetected here. Both free and bound grapefruit-like 3-sulfanyl-4-methylpentan-1-ol (never evidenced before the present work) emerged as discriminating compounds for the Hallertau Blanc variety. The apotryptophanase assay also allowed us to evidence for the first time an S-conjugate of 2-sulfanylethan-1-ol.

  11. Decadal region-wide and glacier-wide mass balances derived from multi-temporal ASTER satellite digital elevation models. Validation over the Mont-Blanc area

    NASA Astrophysics Data System (ADS)

    Berthier, Etienne; Cabot, Vincent; Vincent, Christian; Six, Delphine

    2016-06-01

    Since 2000, a vast archive of stereo-images has been built by the Advanced Spaceborne Thermal Emission and Reflection (ASTER) satellite. Several studies already extracted glacier mass balances from multi-temporal ASTER digital elevation models (DEMs) but they lacked accurate independent data for validation. Here, we apply a linear regression to a time series of 3D-coregistered ASTER DEMs to estimate the rate of surface elevation changes (dh/dtASTER) and geodetic mass balances of Mont-Blanc glaciers (155 km²) between 2000 and 2014. Validation using field and spaceborne geodetic measurements reveals large errors at the individual pixel level (> 1 m a-1) and an accuracy of 0.2-0.3 m a-1 for dh/dtASTER averaged over areas larger than 1 km². For all Mont-Blanc glaciers, the ASTER region-wide mass balance (-1.05±0.37 m water equivalent (w.e.) a-1) agrees remarkably with the one measured using Spot5 and Pléiades DEMs (-1.06±0.23 m w.e. a-1) over their common 2003-2012 period. This multi-temporal ASTER DEM strategy leads to smaller errors than the simple differencing of two ASTER DEMs. By extrapolating dh/dtASTER to mid-February 2000, we infer a mean penetration depth of about 9±3 m for the C-band Shuttle Radar Topographic Mission (SRTM) radar signal, with a strong altitudinal dependency (range 0-12 m). This methodology thus reveals the regional pattern of glacier surface elevation changes and improves our knowledge of the penetration of the radar signal into snow and ice.

  12. Melatonin MT1 and MT2 Receptors in the Ram Reproductive Tract

    PubMed Central

    González-Arto, Marta; Aguilar, David; Gaspar-Torrubia, Elena; Gallego, Margarita; Carvajal-Serna, Melissa; Herrera-Marcos, Luis V.; Serrano-Blesa, Edith; Hamilton, Thais Rose dos Santos; Pérez-Pé, Rosaura; Muiño-Blanco, Teresa; Cebrián-Pérez, José A.; Casao, Adriana

    2017-01-01

    Some melatonin functions in mammals are exerted through MT1 and MT2 receptors. However, there are no reports of their presence in the reproductive tract of the ram, a seasonal species. Thus, we have investigated their existence in the ram testis, epididymis, accessory glands and ductus deferens. Real-time polymerase chain reaction (qPCR) revealed higher levels of m-RNA for both receptors in the testis, ampulla, seminal vesicles, and vas deferens, than in the other organs of the reproductive tract (p < 0.05). Western blot analyses showed protein bands compatible with the MT1 in the testis and cauda epididymis, and for the MT2 in the cauda epididymis and deferent duct. Immunohistochemistry analyses revealed the presence of MT1 receptors in spermatogonias, spermatocytes, and spermatids, and MT2 receptors in the newly-formed spermatozoa in the testis, whereas both receptors were located in the epithelial cells of the ampulla, seminal vesicles, and ductus deferens. Indirect immunofluorescence showed significant differences in the immunolocation of both receptors in spermatozoa during their transit in the epididymis. In conclusion, it was demonstrated that melatonin receptors are present in the ram reproductive tract. These results open the way for new studies on the molecular mechanism of melatonin and the biological significance of its receptors. PMID:28335493

  13. Field transplantation of the freshwater bivalve Corbicula fluminea along a polymetallic contamination gradient (River Lot, France): 2. Metallothionein response to metal exposure

    SciTech Connect

    Baudrimont, M.; Andres, S.; Metivaud, J.; Lapaquellerie, Y.; Ribeyre, F.; Maillet, N.; Latouche, C.; Boudou, A.

    1999-11-01

    Specimens of the Asiatic clam Corbicula fluminea were transplanted from a clean lacustrine site to four stations along a polymetallic pollution gradient in the river Lot, France, downstream from an old Zn ore treatment facility (see Part 1). From April to September 1996, the authors studied Cd and Zn bioaccumulation and the metallothionein-like metal-binding protein (MT) concentrations by subsampling the ages at t = 0, 21, 49, 85, 120, and 150 d. Marked differences were observed among the four stations. At the most polluted station Riou-Mort, MT concentrations did not increase despite very rapid metal accumulation; all mollusks died between days 49 and 85, suggesting that the metal detoxification mechanisms were overwhelmed at this station. At the next station downstream, the final levels of bioaccumulated metal after 150 d were as high as those at the Riou-Mort station, but in this case the MT concentrations also increased progressively with positive correlations between MT and metal concentrations; no mortality was observed, but a significant growth inhibition was revealed in comparison to the reference site, with a lack of correlation between MT and reduced growth. Subcellular metal partitioning, as determined by size-exclusion chromatography, revealed that most of the Cd was sequestered by MT. In contrast, most of the Zn was bound to low molecular weight proteins, the MT fraction representing only 12% of cytosolic zn. These data show the marked role of MT toward Cd bioaccumulation and toxic effects on this freshwater bivalve species.

  14. Photovoltaic rural electrification in France

    SciTech Connect

    Claverie, A.; Courtiade, P.; Vezin, P.

    1994-12-31

    The promotional programs sponsored by ADEME to encourage the use of off-grid photovoltaic power systems have evolved over the last ten years. From the first year-round residences that were equipped in the early 1980s, to those that are now participating in the program set up jointly by ADEME and the electricity utility Electricite de France (EDF), the notions of service quality and longevity are now better adapted to users` needs. This article outlines the evolution of ADEME`s approach in mainland France, describes the program undertaken in the French territory of New Caledonia, and lastly summarizes the results of a field survey of users of stand-alone photovoltaic systems in the French overseas department of Guadeloupe.

  15. [End of life in France].

    PubMed

    Vacheron, André

    2013-01-01

    Two major changes in end-of-life management have occured in recent decades: first, because of the increase in life expectancy and the resulting aging of the population, most deaths now involve old or very old people; second, more than two-thirds of deaths occur in a hospital or an institution. Our fellow citizens are afraid of suffering and death. They wish for a peaceful death, as rapid as possible and, in recent surveys, say they favour euthanasia. Yet euthanasia is illegal in France and in most other Western countries (with the exception of the Benelux nations). Palliative care ensures dignity in death, without anxiety of suffering, and is expanding rapidly in France. Léonetti's law of 22 April 2005 ensures the protection of the weakest, who should never be considered unworthy of life, yet is poorly known to the public and even to physicians. It now needs to be applied in practice.

  16. "Franklin: Science, Politics and France"

    NASA Astrophysics Data System (ADS)

    McClellan, James E., III

    2003-04-01

    This presentation traces Benjamin Franklin's career as a "civic scientist" in Old-Regime France. It outlines the initial - and not always positive - reception of Franklin's work on electricity by the community of French scientists in the 1750s. It sketches Franklin's subsequent elevation into the pantheon of French Enlightenment heros, and it details his work as a "civic scientist" while American envoy to France in the 1770s and 1780s, notably his service on the government-sponsored commissions that repudiated the scientific and medical claims of Franz Anton Mesmer. This presentation concludes by examining a few features of Franklin's career that are not completely congruent with our notion of what a "civic scientist" might be, a contrast that is intended to illuminate both Franklin and the concept of "civic scientist."

  17. Human coronavirus NL63, France.

    PubMed

    Vabret, Astrid; Mourez, Thomas; Dina, Julia; van der Hoek, Lia; Gouarin, Stéphanie; Petitjean, Joëlle; Brouard, Jacques; Freymuth, François

    2005-08-01

    The human coronavirus NL63 (HCoV-NL63) was first identified in The Netherlands, and its circulation in France has not been investigated. We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 respiratory specimens for HCoV-NL63. Of the 300 samples, 28 (9.3%) were positive for HCoV-NL63. The highest prevalence was found in February (18%). The main symptoms were fever (61%), rhinitis (39%), bronchiolitis (39%), digestive problems (33%), otitis (28%), pharyngitis (22%), and conjunctivitis (17%). A fragment of the spike protein gene was sequenced to determine the variety of circulating HCoV-NL63. Phylogenetic analysis indicated that strains with different genetic markers cocirculate in France.

  18. Human embryo research in France.

    PubMed

    Viville, Stéphane; Ménézo, Yves

    2002-02-01

    The French law on bioethics, voted upon in July 1994, is going to be revised. This is the occasion for France to reconsider its position concerning research on human embryos, which is currently prohibited in France, as it is in Germany, Switzerland and Austria. However, such research is authorised in other European countries such as the UK, Spain, Belgium, Italy and The Netherlands. The establishment of human embryonic stem (ES) cells has reopened the debate in France because of their potential in human therapy. Indeed, ES cells, derived from early embryos (5-6 days old), preserve in vitro a pluripotent character, and they could provide an infinite source of different tissues that could be used in replacement therapy. This consists of ES cells differentiated in vitro into the desired tissues or cell types and grafted into the patient. The use of human ES cells in replacement therapy raises the major problem of graft rejection. One of the proposed solutions would be to carry out a 'therapeutic cloning' and to derive ES cells from the embryos obtained in this way. We do consider that, for the moment, the interest of the cloning study lies mainly in the understanding of the mechanisms responsible for reprogramming the nuclei. This research can be performed first on animal models. France is now thinking to allow human embryo research. We present here the French law proposed on human embryo research. French government is proposing to allow research exclusively on frozen supernumerary embryos, which no longer have any parental or adoption potential. Creation of human embryos for research purposes will still be prohibited. However, allowance of studies on human cloning in order to realise therapeutic cloning is mentioned in the proposal. We think that allowing research in humans on therapeutic cloning is premature and contradicts the prohibition of the creation of human embryos for research.

  19. [Epidemiology of burns in France].

    PubMed

    Latarjet, Jacques; Ravat, François

    2012-01-01

    As with most traumas, the epidemiology of the "burn" health-event has long been neglected by public health doctors and rarely considered by burns specialists. There were therefore few verified data and many approximations and preconceived ideas. The gathering of information recently undertaken in France enables the reliability of the data to be improved and the diagnostic and demographic elements relating to hospitalised patients with burns to be established.

  20. Post Eruption Hazards at Mt. Pinatubo, Philippines

    NASA Technical Reports Server (NTRS)

    Mouginis-Mark, Peter J.

    2004-01-01

    Our project focused on the investigation of the post-eruption hazards at Mt. Pinatubo (Philippines) using remote sensing data, and field observations of the 1991 eruption deposits. Through the use of multiple satellite images, field work, and the 1996/2000 PacRim data sets, we conducted studies of the co- and post-eruption hazards of the volcano due to erosion and re-deposition of the extensive pyroclastic flow deposits. A major part of this project was the assembly and analysis of a database of over 50 high resolution (1 - 50 m/pixel) images that will facilitate this study. We collected Ikonos, SPOT, SIR-C/X-SAR, Landsat, ERS, RADARSAT, and ASTER images of the area around Mt. Pinatubo. An example of the changes that could be seen in these data is shown. Our investigation focused on a retrospective analysis of the erosion, redeposition, and re-vegetation of the 1991 pyroclastic flow deposits of Mt. Pinatubo. The primary geologic goal of our work was the analysis of the spatial distribution and volume change of the sources and sinks of materials associated with mudflow ('lahar') events. This included the measurement of river valley gradients and cross-sections using TOPSAR digital elevation data, as we are participating in the PacRim 2000 deployment to the Philippines specifically so that we can collect a second set of TOPSAR data that can then be used to create a topographic difference image of the volcano. The main results from this multi-sensor study have been published as Torres et al.. A discussion of the methodology that we used to assemble an appropriate database was included in Mouginis-Mark and Domergue-Schmidt. As part of an educational outreach effort, we also helped the Philippine Institute of Volcanology and Seismology (PHIVOLCS) in the Philippines to use NASA data to study Mt. Pinatubo and other Filipino volcanoes.

  1. Mt. Pinatubo Volcano - Post Eruption, Luzon, Philippines

    NASA Image and Video Library

    1992-08-08

    Mt. Pinatubo on the island of Luzon (15.0N, 120.0E) erupted catastrophically in June 1991 after over 600 years of inactivity. In this vertical view, the full extent of the eruption is obvious. Thick layers of ash completely surrounds the crater and the effect of mudflows in this previously heavily forested and agricultural region can be traced as ribbons flowing downhill. Clark AFB, once the crossroads of the SW Pacific can only partially be seen.

  2. Graphs for Isotopes of 109-Mt (Meitnerium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides a graphic representation of nucleon separation energies and residual interaction parameters for isotopes of the chemical element 109-Mt (Meitnerium, atomic number Z = 109).

  3. Mt. Pinatubo Volcano - Post Eruption, Luzon, Philippines

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Mt. Pinatubo on the island of Luzon (14.5N, 120.5E) erupted catastrophically in June 1991 after over 600 years of inactivity. Partially obscured by clouds in this post eruption photo, the crater is not obvious in this scene but the blowout area, in the once heavily forested region, is easily observed as lava flow, ash fallout, mud slide and debris trails mar the landscape. Clark AFB, once the crossroads of the SW Pacific can only partially be seen.

  4. Area MT Encodes Three-Dimensional Motion

    PubMed Central

    Huk, Alexander C.; Cormack, Lawrence K.; Kohn, Adam

    2014-01-01

    We use visual information to determine our dynamic relationship with other objects in a three-dimensional (3D) world. Despite decades of work on visual motion processing, it remains unclear how 3D directions—trajectories that include motion toward or away from the observer—are represented and processed in visual cortex. Area MT is heavily implicated in processing visual motion and depth, yet previous work has found little evidence for 3D direction sensitivity per se. Here we use a rich ensemble of binocular motion stimuli to reveal that most neurons in area MT of the anesthetized macaque encode 3D motion information. This tuning for 3D motion arises from multiple mechanisms, including different motion preferences in the two eyes and a nonlinear interaction of these signals when both eyes are stimulated. Using a novel method for functional binocular alignment, we were able to rule out contributions of static disparity tuning to the 3D motion tuning we observed. We propose that a primary function of MT is to encode 3D motion, critical for judging the movement of objects in dynamic real-world environments. PMID:25411482

  5. Modeling the Geologic History of Mt. Sharp

    NASA Technical Reports Server (NTRS)

    Pascuzzo, A.; Allen, C.

    2015-01-01

    Gale is an approximately 155 km diameter crater located on the martian dichotomy boundary (5 deg S 138 deg E). Gale is estimated to have formed 3.8 - 3.5 Gya, in the late Noachian or early Hesperian. Mt. Sharp, at the center of Gale Crater, is a crescent shaped sedimentary mound that rises 5.2 km above the crater floor. Gale is one of the few craters that has a peak reaching higher than the rim of the crater wall. The Curiosity rover is currently fighting to find its way across a dune field at the northwest base of the mound searching for evidence of habitability. This study used orbital images and topographic data to refine models for the geologic history of Mt. Sharp by analyzing its morphological features. In addition, it assessed the possibility of a peak ring in Gale. The presence of a peak ring can offer important information to how Mt. Sharp was formed and eroded early in Gale's history.

  6. Novel Scalable 3-D MT Inverse Solver

    NASA Astrophysics Data System (ADS)

    Kuvshinov, A. V.; Kruglyakov, M.; Geraskin, A.

    2016-12-01

    We present a new, robust and fast, three-dimensional (3-D) magnetotelluric (MT) inverse solver. As a forward modelling engine a highly-scalable solver extrEMe [1] is used. The (regularized) inversion is based on an iterative gradient-type optimization (quasi-Newton method) and exploits adjoint sources approach for fast calculation of the gradient of the misfit. The inverse solver is able to deal with highly detailed and contrasting models, allows for working (separately or jointly) with any type of MT (single-site and/or inter-site) responses, and supports massive parallelization. Different parallelization strategies implemented in the code allow for optimal usage of available computational resources for a given problem set up. To parameterize an inverse domain a mask approach is implemented, which means that one can merge any subset of forward modelling cells in order to account for (usually) irregular distribution of observation sites. We report results of 3-D numerical experiments aimed at analysing the robustness, performance and scalability of the code. In particular, our computational experiments carried out at different platforms ranging from modern laptops to high-performance clusters demonstrate practically linear scalability of the code up to thousands of nodes. 1. Kruglyakov, M., A. Geraskin, A. Kuvshinov, 2016. Novel accurate and scalable 3-D MT forward solver based on a contracting integral equation method, Computers and Geosciences, in press.

  7. Application of remote sensing analysis and MT method for identification geothermal prospect zone in Mt. Endut

    NASA Astrophysics Data System (ADS)

    Akbar, A. M.; Permadi, A. N.; Wildan, D.; Sobirin, R.; Supriyanto

    2017-07-01

    Mount Endut is located at Banten Province, 40 km southward Rangkasbitung City, with geographic UTM position between 9261000-9274000 N and 639000-652000 E. Preliminary survey at Mt. Endut was geological and geochemical survey in 2006, resistivity survey and MT survey in 2007 with 27 measurement point. All survey conducted by Pusat Sumber Daya Geologi (PSDG). According to result of premilinary survey, Mt. Endut is dominated by quartenary volcanic rock produced by Mt. Endut, which breakthrough tertiary sediment layer. NE to SW normal fault produced surface manifestation, namely Cikawah (CKW) hot spring and Handeleum (HDL) hot spring. According to SiO2 and NaK geothermometer, subsurface temperature of Mt Endut is ranging from 162 to 180 °C. Apparent resistivity maps show that thermal manifestation areas coincide with pronounced high anomaly due to resistive intrusion bodies contrast to conductive sedimentary basements. In order to delineate permeability zone, fracture fault density (FFD) analysis from remote sensing image is carry out. FFD analysis from lansdat 7 image shows the area on westward flank of Mt. Endut have high fracture fault density (162-276 m/km2), higher than it's surrounding area and can be assume that area is weak zone and have high permeability. That's structure density anomaly coincide with low resistivity from Magnetotelluric data. Resistivity structure from Magnetotelluric data shows western flank have low permeability layer (14-27 Ohmm) with average thickness 250 m. Below this layer there is layer with higher resistivity (37-100 Ohmm) with ±1000 m depth and interpreted as shallow reservoir. Massive resistif intrusive bodies act controlled the surface manifestation, and act as boundary and bounded the geothermal system in western part of Mt. Endut.

  8. MtDNA COI-COII marker and drone congregation area: an efficient method to establish and monitor honeybee (Apis mellifera L.) conservation centres.

    PubMed

    Bertrand, Bénédicte; Alburaki, Mohamed; Legout, Hélène; Moulin, Sibyle; Mougel, Florence; Garnery, Lionel

    2015-05-01

    Honeybee subspecies have been affected by human activities in Europe over the past few decades. One such example is the importation of nonlocal subspecies of bees which has had an adverse impact on the geographical repartition and subsequently on the genetic diversity of the black honeybee Apis mellifera mellifera. To restore the original diversity of this local honeybee subspecies, different conservation centres were set up in Europe. In this study, we established a black honeybee conservation centre Conservatoire de l'Abeille Noire d'Ile de France (CANIF) in the region of Ile-de-France, France. CANIF's honeybee colonies were intensively studied over a 3-year period. This study included a drone congregation area (DCA) located in the conservation centre. MtDNA COI-COII marker was used to evaluate the genetic diversity of CANIF's honeybee populations and the drones found and collected from the DCA. The same marker (mtDNA) was used to estimate the interactions and the haplotype frequency between CANIF's honeybee populations and 10 surrounding honeybee apiaries located outside of the CANIF. Our results indicate that the colonies of the conservation centre and the drones of the DCA show similar stable profiles compared to the surrounding populations with lower level of introgression. The mtDNA marker used on both DCA and colonies of the conservation centre seems to be an efficient approach to monitor and maintain the genetic diversity of the protected honeybee populations. © 2014 John Wiley & Sons Ltd.

  9. [Suicide and occupation in France].

    PubMed

    Cohidon, C; Santin, G; Geoffroy-Perez, B; Imbernon, E

    2010-04-01

    Suicide is a complex and multifactorial phenomenon. The number of work-related suicides is difficult to assess in France. There are nevertheless some data available to document this problem. The aim of this study is to describe suicide attempts (SA) and suicide mortality according to occupation in France. The description of SA relies on the "Baromètre Santé 2005", a cross-sectional representative survey conducted by the Inpes in France. The study population includes 6264 men and 7389 women in employment at the time of the survey. The prevalence of all life SA is described according to occupational category (one and two digits). Data on suicide mortality before the age of 65 comes from the Cosmop project, conducted by the Department of Occupational Health/InVS, and based on data from the "Echantillon démographique permanent"/Insee linked to medical causes of death from the French national death registry (CepiDc/Inserm). People included was born in France, employed at one of censuses (1968, 1975, 1982 and 1990, 187,938 men, 150,683 women). Relative risks for suicide mortality were estimated for the last known occupational category and economic sector. The prevalence of life course SA was higher among women than among men (6.6% vs 3.1%); an opposite situation was observed for mortality. Regarding salaried people, categories of manual workers and clerks are the most affected by SA and mortality from suicide whereas executives are the least concerned. Farmers were little affected by SA (0.4% men, 4.1% women) but experienced the highest rate of mortality by suicide (RR=3.1 men, RR=2.2 women). Among women, compared to non market sectors, the agricultural and equipment goods sectors exhibited an excessive risk of mortality from suicide. This study points out SA and mortality from suicide inequalities by occupational categories and to a lesser extent by economic sector. These results provide a first assessment on suicide according to occupation in France.

  10. Mt. Kilimanjaro expedition in earth science education

    NASA Astrophysics Data System (ADS)

    Sparrow, Elena; Yoshikawa, Kenji; Narita, Kenji; Brettenny, Mark; Yule, Sheila; O'Toole, Michael; Brettenny, Rogeline

    2010-05-01

    Mt. Kilimanjaro, Africa's highest mountain is 5,895 meters above sea level and is located 330 km south of the equator in Tanzania. In 1976 glaciers covered most of Mt. Kilimanjaro's summit; however in 2000, an estimated eighty percent of the ice cap has disappeared since the last thorough survey done in 1912. There is increased scientific interest in Mt. Kilimanjaro with the increase in global and African average temperatures. A team of college and pre-college school students from Tanzania, South Africa and Kenya, teachers from South Africa and the United States, and scientists from the University of Alaska Fairbanks in the United States and Akita University in Japan, climbed to the summit of Mt Kilimanjaro in October 2009. They were accompanied by guides, porters, two expedition guests, and a videographer. This expedition was part of the GLOBE Seasons and Biomes Earth System Science Project and the GLOBE Africa science education initiative, exploring and contributing to climate change studies. Students learned about earth science experientially by observing their physical and biological surroundings, making soil and air temperature measurements, participating in discussions, journaling their experience, and posing research questions. The international trekkers noted the change in the biomes as the altitude, temperature and conditions changed, from cultivated lands, to rain forest, heath zone, moorland, alpine desert, and summit. They also discovered permafrost, but not at the summit as expected. Rather, it was where the mountain was not covered by a glacier and thus more exposed to low extreme temperatures. This was the first report of permafrost on Mt. Kilimanjaro. Classrooms from all over the world participated in the expedition virtually. They followed the trek through the expedition website (http://www.xpeditiononline.com/) where pictures and journals were posted, and posed their own questions which were answered by the expedition and base camp team members

  11. METHYLATION OF ARSENIC BY RECOMBINANT HUMAN AS3MT/287M AND AS3MT/287T POLYMORPHS

    EPA Science Inventory

    Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the pathway for methylation of inorganic arsenic (iAs). AS3MT polymorphism is, in part, responsible for interindividual differences in iAs metabolism. AS3MT/M287T polymorphism that is found in ~ 10% of C...

  12. METHYLATION OF ARSENIC BY RECOMBINANT HUMAN AS3MT/287M AND AS3MT/287T POLYMORPHS

    EPA Science Inventory

    Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the pathway for methylation of inorganic arsenic (iAs). AS3MT polymorphism is, in part, responsible for interindividual differences in iAs metabolism. AS3MT/M287T polymorphism that is found in ~ 10% of C...

  13. Analysis of mtDNA/nDNA Ratio in Mice.

    PubMed

    Quiros, Pedro M; Goyal, Aashima; Jha, Pooja; Auwerx, Johan

    2017-03-02

    Mitochondrial DNA (mtDNA) lacks the protection provided by the nucleosomes in the nuclear DNA and does not have a DNA repair mechanism, making it highly susceptible to damage, which can lead to mtDNA depletion. mtDNA depletion compromises the efficient function of cells and tissues and thus impacts negatively on health. Here, we describe a brief and easy protocol to quantify mtDNA copy number by determining the mtDNA/nDNA ratio. The procedure has been validated using a cohort of young and aged mice. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc.

  14. Learning motion discrimination with suppressed and un-suppressed MT.

    PubMed

    Thompson, Benjamin; Liu, Zili

    2006-06-01

    Perceptual learning of motion direction discrimination is generally thought to rely on the middle temporal area of the brain (MT/V5). A recent study investigating learning of motion discrimination when MT was psychophysically suppressed found that learning was possible with suppressed MT, but only when the task was sufficiently easy [Lu, H., Qian, N., Liu, Z. (2004). Learning motion discrimination with suppressed MT. Vision Research 44, 1817-1825]. We investigated whether this effect was indeed due to MT suppression or whether it could be explained by task difficulty alone. By comparing learning of motion discrimination when MT was suppressed vs. un-suppressed, at different task difficulties, we found that task difficulty alone could not explain the effects. At the highest difficulty, learning was not possible with suppressed MT, confirming [Lu, H., Qian, N., Liu, Z. (2004). Learning motion discrimination with suppressed MT. Vision Research 44, 1817-1825]. In comparison, learning was possible with un-suppressed MT at the same difficulty level. At the intermediate task difficulty, there was a clear learning disadvantage when MT was suppressed. Only for the easiest level of difficulty, did learning become equally possible for both suppressed and un-suppressed conditions. These findings suggest that MT plays an important role in learning to discriminate relatively fine differences in motion direction.

  15. Genetic Diversity of Talpa Europaea and Nova Hanta Virus (NVAV) in France

    PubMed Central

    Hugot, Jean-Pierre; Gu, Se Hun; Feliu, Carlos; Ventur, Jacint; Ribas, Alexis; Dormion, Jerôme; Yanagihara, Richard; Nicolas, Violaine

    2014-01-01

    Summary Nova hantavirus (NVAV) was first identified in a single European mole (Talpa europaea), captured in Hungary. Analysis of lung tissues from 94 moles captured in France revealed NVAV in 50%. Based on the genetic diversity of the cytochrome b mtDNA, moles collected in Poitiers and Bordeaux were more closely related to the Iberian mole (T. occidentalis), a species previously assumed to be restricted to the Iberian Peninsula. Several hypotheses are discussed to explain these observations: 1) presence of hitherto unnoticed T. occidentalis in southwestern France; 2) existence of an ancient mitochondrial introgression phenomenon between the two Talpa species, producing a particular phenotype in some hybrids; 3) existence of a hybrid zone between the two species; and 4) existence of a new Talpa species. NVAV was not detected in the southwestern moles, which begs the question of the potential presence of a particular Hantavirus sp. in this population and/or in the Iberian moles. PMID:25530620

  16. Genetic Diversity of Talpa Europaea and Nova Hanta Virus (NVAV) in France.

    PubMed

    Hugot, Jean-Pierre; Gu, Se Hun; Feliu, Carlos; Ventur, Jacint; Ribas, Alexis; Dormion, Jerôme; Yanagihara, Richard; Nicolas, Violaine

    2014-01-01

    Nova hantavirus (NVAV) was first identified in a single European mole (Talpa europaea), captured in Hungary. Analysis of lung tissues from 94 moles captured in France revealed NVAV in 50%. Based on the genetic diversity of the cytochrome b mtDNA, moles collected in Poitiers and Bordeaux were more closely related to the Iberian mole (T. occidentalis), a species previously assumed to be restricted to the Iberian Peninsula. Several hypotheses are discussed to explain these observations: 1) presence of hitherto unnoticed T. occidentalis in southwestern France; 2) existence of an ancient mitochondrial introgression phenomenon between the two Talpa species, producing a particular phenotype in some hybrids; 3) existence of a hybrid zone between the two species; and 4) existence of a new Talpa species. NVAV was not detected in the southwestern moles, which begs the question of the potential presence of a particular Hantavirus sp. in this population and/or in the Iberian moles.

  17. CFB boiler at Gardanne (France)

    SciTech Connect

    Jaud, P.; Jacquet, L.; Delot, P.; Bayle, F.

    1995-06-01

    Among the new Clean Coal Technologies, {open_quotes}Circulating Fluidized Bed{close_quotes} is one of the most promising. Today, the largest project in commissioning`s the 250 MWe Provence CFB boiler, located near MARSEILLE in the south of France. At such a size, the CFB technique has now reached a capacity corresponding to thermal power plants operated by utilities. This new unit is a very important step towards larger size i.e. 400 MWe and greater. The SO{sub 2} emissions of this CFB boiler are guaranteed to be less than 400 mg / Nm{sup 3} at 6% O{sub 2} with the ratio of Ca/S lower than 3 while total sulfur in local coal used can reach 3.68 %. The purpose of the Provence project was to replace the existing pulverized coal boiler unit 4, commissioned in 1967, of the Provence power plant, with a new CFB boiler while reusing most of the existing equipment. The new boiler has been ordered from GEC ALSTHOM STEIN INDUSTREE (GASI) by Electricite de France (EDF) on behalf of the SOPROLIF consortium. Architect Engineering and construction management was performed by EDF jointly with Charbonnages de France (CdF: the French Coal Board). The 250 MWe CFB boiler is of the superheat-reheat type. The first firing of the boiler is due in April 1995. The poster session will describe the progress in the construction of the plant and provides technical details of the new boiler and auxiliaries.

  18. [Access to medicines in France].

    PubMed

    Bouvenot, Gilles; Bouvenot, Julien

    2009-03-01

    In France the total cost of medicinal products reimbursed by health insurers in 2007 was over 25 thousand million euros, and access to new drugs is neither restricted nor rationed, despite the unfavorable economic situation. In 2007 and 2008 the Transparency Commission (TC) of the French National Authority for Health (Haute Autorité de Santé) approved the reimbursement of 97% of new drugs and new indications for existing products, within 90 days on average. The 3% of medicinal products that were not approved did not represent therapeutic advances and could be considered to be of dubious utility. If evaluation of new drugs is to be an independent process, then HAS must not only be independent of the decision-maker, funding bodies and commercial firms, but must also be a purely medical and technical organization. This implies removing all financial consideration from the picture, including the size of the target population that may qualify for a new treatment. This system could be further improved by creating special procedures to promote funding for innovations outside the marketing authorization system, thereby providing patients with faster access to the drugs they need; these procedures would include temporary authorisation, temporary treatment protocols, and a special-case function for treatment of chronic and rare conditions. Currently, new treatments produced by the pharmaceutical industry are paid for by national funding bodies and, from this point of view, it is difficult to argue that drug innovation is under-supported in France. On the other hand, it is well known that France has long been the largest consumer of medicinal drugs, both in Europe and worldwide. Two behavioral patterns partially explain this situation: one is a tendency to believe that drugs are the answer to all health concerns, and the other is a preference for new, more expensive drugs, even though "never" is not necessarily "better".

  19. [Health and politics in France].

    PubMed

    Tabuteau, Didier

    2012-06-01

    Health is a dual notion. It is individual, singular and intimate. It is also collective, statistical and political. The modern problematic of health relies upon a balance of complex relations between individual and collective acceptances of the notion. You can try to outline the evolutions and the main concepts through a quadruple approach: health and politics, health and its professionals, health and society and in the end, health and the State. The relationships between health and politics in France are affected by the historical delay of France in public health, namely because of a structural weakness of the administrative organization of public health. Nevertheless France developed a dense and well organized care system and a universal social protection against the disease. The creation of the health professions in France was marked by a historical opposition between the doctors and the state which led to a failure of hygienist medicine and a fundamental misunderstanding on health insurance. Medical domination led to the organization of a system based on professional dichotomy and the delegation of the regulation skills to the health care professionals. The role of health issues in the French society was deeply renewed by the development of the medical and epidemiological knowledge. This resulted in a new political responsibility in the management of health risks but also in the confirmation of the patients' rights and the role of their associations in the health systems operations and the piloting of public policies. In this environment, the state has recently and progressively confirmed its dominating role in the health sector. A public hospital service was created In the 60's and 70's, then in the 80's there were recurrent interventions in order to control health spendings and eventually in the 90's health safety devices were set up. More recently, a process of health policies institutionalization confirmed this evolution. In the future, health issues should

  20. The MU-RAY project: detector technology and first data from Mt. Vesuvius

    NASA Astrophysics Data System (ADS)

    Ambrosino, F.; Anastasio, A.; Basta, D.; Bonechi, L.; Brianzi, M.; Bross, A.; Callier, S.; Caputo, A.; Ciaranfi, R.; Cimmino, L.; D'Alessandro, R.; D'Auria, L.; de La Taille, C.; Energico, S.; Garufi, F.; Giudicepietro, F.; Lauria, A.; Macedonio, G.; Martini, M.; Masone, V.; Mattone, C.; Montesi, M. C.; Noli, P.; Orazi, M.; Passeggio, G.; Peluso, R.; Pla-Dalmau, A.; Raux, L.; Rubinov, P.; Saracino, G.; Scarlini, E.; Scarpato, G.; Sekhniaidze, G.; Starodubtsev, O.; Strolin, P.; Taketa, A.; Tanaka, H. K. M.; Vanzanella, A.; Viliani, L.

    2014-02-01

    Muon Radiography allows to map the density of a volcanic cone. It is based on the measurement of the attenuation of the flux of muons present in the cosmic radiation on the ground. The MU-RAY project has developed an innovative detector designed for the muon radiography. The main features are the low electric power consumption, robustness and transportability, good spatial resolution and muon time of flight measurement. A 1 m2 detector prototype has been constructed. and collected data at Mt. Vesuvius for approximately 1 month in spring 2013. A second campaign of measurement has been performed at the Puy de Dôme, France, in the last four months of 2013. In this article the principles of muon radiography, the MU-RAY detector and the first results from the collected data will be described.

  1. Improving the Terrain-Based Parameter for the Assessment of Snow Redistribution in the Col du Lac Blanc Area and Comparisons with TLS Snow Depth Data

    NASA Astrophysics Data System (ADS)

    Schön, Peter; Prokop, Alexander; Naaim-Bouvet, Florence; Nishimura, Kouichi; Vionnet, Vincent; Guyomarc'h, Gilbert

    2014-05-01

    Wind and the associated snow drift are dominating factors determining the snow distribution and accumulation in alpine areas, resulting in a high spatial variability of snow depth that is difficult to evaluate and quantify. The terrain-based parameter Sx characterizes the degree of shelter or exposure of a grid point provided by the upwind terrain, without the computational complexity of numerical wind field models. The parameter has shown to qualitatively predict snow redistribution with good reproduction of spatial patterns, but has failed to quantitatively describe the snow redistribution, and correlations with measured snow heights were poor. The objective of our research was to a) identify the sources of poor correlations between predicted and measured snow re-distribution and b) improve the parameters ability to qualitatively and quantitatively describe snow redistribution in our research area, the Col du Lac Blanc in the French Alps. The area is at an elevation of 2700 m and particularly suited for our study due to its constant wind direction and the availability of data from a meteorological station. Our work focused on areas with terrain edges of approximately 10 m height, and we worked with 1-2 m resolution digital terrain and snow surface data. We first compared the results of the terrain-based parameter calculations to measured snow-depths, obtained by high-accuracy terrestrial laser scan measurements. The results were similar to previous studies: The parameter was able to reproduce observed patterns in snow distribution, but regression analyses showed poor correlations between terrain-based parameter and measured snow-depths. We demonstrate how the correlations between measured and calculated snow heights improve if the parameter is calculated based on a snow surface model instead of a digital terrain model. We show how changing the parameter's search distance and how raster re-sampling and raster smoothing improve the results. To improve the parameter

  2. Two year study of CO2, CH4 and N2O dynamics and fluxes in four rivers in Belgium (Meuse, Ourthe, Geer and Blanc Gravier)

    NASA Astrophysics Data System (ADS)

    Borges, Alberto V.; Darchambeau, François; Beulen, Aurore

    2013-04-01

    Two rivers and two streams close to the city of Liège in Belgium (Meuse, Ourthe, Geer and Blanc Gravier) were sampled to describe the dynamics of CO2, CH4 and N2O (for the first time in Belgium for freshwaters). The four systems were chosen to cover a gradient of size (stream to river) and of human influence (mainly forested to mainly agricultural watersheds). The study covers the period from February 2011 to March 2013 with weekly sampling in surface waters. The variables were very contrasted in the four systems, the Geer showing a strong enrichment in nitrogen NH4+ et NO2-) and phosphorous in relation to the other three systems. The O2 concentrations were much lower, and the concentration of CH4, N2O and pCO2 were much higher in the Geer than in other three systems. The concentrations in CH4, N2O and pCO2 were higher in the Ourthe than in the Meuse and than in the Blanc Gravier. Marked seasonal variations were observed in the 4 systems. In general the concentration of CH4, N2O and pCO2 were higher in summer than in winter. This is related on one hand to the increase of temperature in summer that stimulates bacterial activity. Also in summer, the availability of organic matter for bacterial activity is higher after the spring phytoplankton blooms and also from allochthnous inputs from the watersheds. The increase of temperature and bacterial consumption of O2 in the water column leads to a lesser O2 penetration in the sediments that could stimulate benthic anaerobic processes among which methanogenesis and denitrification, leading to an increase of CH4 and N2O in the water column. Also, the production of N2O by denitrification strongly increases at low O2. During low water, the increase of residence time of the water mass and the decrease of current (decrease of degasing) allow an accumulation of CO2, CH4 and N2O in the water column. On the contrary during high water, dilution and increase of current (increase of degasing) lead to a decrease of concentrations

  3. Mt. Pinatubo Volcano - Post Eruption, Luzon, Philippines

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Mt. Pinatubo on the island of Luzon (15.5N, 120.0E) erupted catastrophically in June 1991 after over 600 years of inactivity. This is the first shuttle post eruption photo. The north facing crater is not obvious in this scene but the blowout area, in the once heavily forested region, is easily observed as lava flow, ash fallout, mud slide and debris trails mar the landscape. Clark AFB, once the crossroads of the SW Pacific can only partially be seen.

  4. Eurotra: A European perspective on MT

    SciTech Connect

    Arnold, D.

    1986-07-01

    This paper describes the perspective on Machine Translation taken in the Eurotra project: an R and D project of the European Communities at a relatively early stage. It describes: i) the project's rather challenging aims; ii) the framework of design principles and linguistic and software methodology which are of particular importance given its size, scope, and organization; iii) the proposed representational theories and expressive (programming) languages with which actual instances of MT systems can be constructed. The final section sketches some recent proposals and directions for future research.

  5. Merging a Terrain-Based Parameter and Snow Particle Counter Data for the Assessment of Snow Redistribution in the Col du Lac Blanc Area

    NASA Astrophysics Data System (ADS)

    Schön, Peter; Prokop, Alexander; Naaim-Bouvet, Florence; Vionnet, Vincent; Guyomarc'h, Gilbert; Heiser, Micha; Nishimura, Kouichi

    2015-04-01

    Wind and the associated snow drift are dominating factors determining the snow distribution and accumulation in alpine areas, resulting in a high spatial variability of snow depth that is difficult to evaluate and quantify. The terrain-based parameter Sx characterizes the degree of shelter or exposure of a grid point provided by the upwind terrain, without the computational complexity of numerical wind field models. The parameter has shown to qualitatively predict snow redistribution with good reproduction of spatial patterns. It does not, however, provide a quantitative estimate of changes in snow depths. The objective of our research was to introduce a new parameter to quantify changes in snow depths in our research area, the Col du Lac Blanc in the French Alps. The area is at an elevation of 2700 m and particularly suited for our study due to its consistently bi-modal wind directions. Our work focused on two pronounced, approximately 10 m high terrain breaks, and we worked with 1 m resolution digital snow surface models (DSM). The DSM and measured changes in snow depths were obtained with high-accuracy terrestrial laser scan (TLS) measurements. First we calculated the terrain-based parameter Sx on a digital snow surface model and correlated Sx with measured changes in snow-depths (Δ SH). Results showed that Δ SH can be approximated by Δ SHestimated = α * Sx, where α is a newly introduced parameter. The parameter α has shown to be linked to the amount of snow deposited influenced by blowing snow flux. At the Col du Lac Blanc test side, blowing snow flux is recorded with snow particle counters (SPC). Snow flux is the number of drifting snow particles per time and area. Hence, the SPC provide data about the duration and intensity of drifting snow events, two important factors not accounted for by the terrain parameter Sx. We analyse how the SPC snow flux data can be used to estimate the magnitude of the new variable parameter α . To simulate the development

  6. From flakes to grooves: a technical shift in antlerworking during the last glacial maximum in southwest France.

    PubMed

    Pétillon, Jean-Marc; Ducasse, Sylvain

    2012-04-01

    The evolution of antlerworking technology in Paleolithic and Mesolithic Europe, especially the production of splinters, is usually described as a cumulative process. A progressive increase in blank standardization and productivity was prompted by the application of a key technical process, the groove and splinter technique (GST). The Badegoulian, however, appears as an interruption in this continuum. According to the original definition of this post-Solutrean, pre-Magdalenian archeological culture, one of its distinctive features is the absence of the GST and the manufacture of antler blanks by knapping only. However, this conception has been recently questioned, leading to an alternative hypothesis suggesting that both GST and knapping were used during the Badegoulian. In this article, we present new evidence from several sites in southwest France, which sheds new light on the issue of Badegoulian antlerworking and the transition with the subsequent Lower Magdalenian. Our study is based on two complementary methods: the technological analysis of antler assemblages well-dated to the Badegoulian (Le Cuzoul de Vers) or to the Lower Magdalenian (La Grotte des Scilles, Saint-Germain-la-Rivière), and the direct (14)C dating of specific antler artifacts from mixed or problematic contexts (Cap-Blanc, Reverdit and Lassac). The results firmly establish that, in southwest France, knapping is the only method used for the production of antler splinters during the Badegoulian, before ca. 20,500 cal BP (calibrated years before present), and that it is rapidly replaced by the GST at the beginning of the Lower Magdalenian, after ca. 20,500 cal BP. This technical shift is not linked to an influx of new human populations, environmental change or the supposed economic advantages of the GST. Instead, it must be understood as one of the expressions of a broader reconfiguration of the technical world that starts to take shape in the middle of the Last Glacial Maximum.

  7. New Radioligands for Describing the Molecular Pharmacology of MT1 and MT2 Melatonin Receptors

    PubMed Central

    Legros, Céline; Matthey, Ulrich; Grelak, Teresa; Pedragona-Moreau, Sandrine; Hassler, Werner; Yous, Saïd; Thomas, Emmanuel; Suzenet, Franck; Folleas, Benoît; Lefoulon, François; Berthelot, Pascal; Caignard, Daniel-Henri; Guillaumet, Gérald; Delagrange, Philippe; Brayer, Jean-Louis; Nosjean, Olivier; Boutin, Jean A.

    2013-01-01

    Melatonin receptors have been studied for several decades. The low expression of the receptors in tissues led the scientific community to find a substitute for the natural hormone melatonin, the agonist 2-[125I]-iodomelatonin. Using the agonist, several hundreds of studies were conducted, including the discovery of agonists and antagonists for the receptors and minute details about their molecular behavior. Recently, we attempted to expand the panel of radioligands available for studying the melatonin receptors by using the newly discovered compounds SD6, DIV880, and S70254. These compounds were characterized for their affinities to the hMT1 and hMT2 recombinant receptors and their functionality in the classical GTPγS system. SD6 is a full agonist, equilibrated between the receptor isoforms, whereas S70254 and DIV880 are only partial MT2 agonists, with Ki in the low nanomolar range while they have no affinity to MT1 receptors. These new tools will hopefully allow for additions to the current body of information on the native localization of the receptor isoforms in tissues. PMID:23698757

  8. New radioligands for describing the molecular pharmacology of MT1 and MT2 melatonin receptors.

    PubMed

    Legros, Céline; Matthey, Ulrich; Grelak, Teresa; Pedragona-Moreau, Sandrine; Hassler, Werner; Yous, Saïd; Thomas, Emmanuel; Suzenet, Franck; Folleas, Benoît; Lefoulon, François; Berthelot, Pascal; Caignard, Daniel-Henri; Guillaumet, Gérald; Delagrange, Philippe; Brayer, Jean-Louis; Nosjean, Olivier; Boutin, Jean A

    2013-04-25

    Melatonin receptors have been studied for several decades. The low expression of the receptors in tissues led the scientific community to find a substitute for the natural hormone melatonin, the agonist 2-[125I]-iodomelatonin. Using the agonist, several hundreds of studies were conducted, including the discovery of agonists and antagonists for the receptors and minute details about their molecular behavior. Recently, we attempted to expand the panel of radioligands available for studying the melatonin receptors by using the newly discovered compounds SD6, DIV880, and S70254. These compounds were characterized for their affinities to the hMT1 and hMT2 recombinant receptors and their functionality in the classical GTPS system. SD6 is a full agonist, equilibrated between the receptor isoforms, whereas S70254 and DIV880 are only partial MT2 agonists, with Ki in the low nanomolar range while they have no affinity to MT1 receptors. These new tools will hopefully allow for additions to the current body of information on the native localization of the receptor isoforms in tissues.

  9. Stereo Image of Mt. Usu Volcano

    NASA Technical Reports Server (NTRS)

    2002-01-01

    On April 3, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra Satellite captured this image of the erupting Mt. Usu volcano in Hokkaido, Japan. This anaglyph stereo image is of Mt Usu volcano. On Friday, March 31, more than 15,000 people were evacuated by helicopter, truck and boat from the foot of Usu, that began erupting from the northwest flank, shooting debris and plumes of smoke streaked with blue lightning thousands of feet in the air. Although no lava gushed from the mountain, rocks and ash continued to fall after the eruption. The region was shaken by thousands of tremors before the eruption. People said they could taste grit from the ash that was spewed as high as 2,700 meters (8,850 ft) into the sky and fell to coat surrounding towns with ash. A 3-D view can be obtained by looking through stereo glasses, with the blue film through your left eye and red film with your right eye at the same time. North is on your right hand side. For more information, see When Rivers of Rock Flow ASTER web page Image courtesy of MITI, ERSDAC, JAROS, and the U.S./Japan ASTER Science Team

  10. Evolution of anorthoclase phonolite, Mt. Erebus, Antarctica

    SciTech Connect

    Moore, J.A.; Kyle, P.R.

    1985-01-01

    Over the last 1 m.y. Mt. Erebus (3794 m) has erupted mainly anorthoclase phonolite (AP) and lesser trachyte, kaersutite phonolite and intermediate differentiates. An active convecting AP lava lake, identical in composition to the older lavas, existed from 1972 until late 1984. Most of the rocks define a strongly undersaturated continuous sodic differentiation series, composed of basanite, Ne-hawaiite, Ne-mugearite, Ne-benmoreite and AP. The main phenocryst phases and their ranges are: olivine (Fo 81-43), clinopyroxene (Wo 50-44, En 42-24, Fs 11-30), opaque oxides (Usp 52-79) and feldspar. Major, trace and REE analyses exhibit smooth trends on variation diagrams. REE are strongly LREE enriched and increase from La/sub N/=220 in the basanites to 400 in AP. There are no significant Eu anomalies. Published isotopic data show derivation of the basanite parental magmas from a depleted (/sup 87/Sr//sup 86/Sr=0.703) heterogeneous mantle source similar to that for oceanic island basalts. Crustal contamination is insignificant except in the trachytes. Evolution of the Erebus lineage by fractional crystallization of the above phases plus apatite is supported by mass balance models. Differentiation probably occurred in larger, hotter and lower P/sub H20/ magma chambers compared to the basanite to kaersutite phonolite DVDP lineage (Kyle, 1981) of the neighboring Hut Point Peninsula. Mt. Erebus may mark the site of a major mantle upwelling.

  11. Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease

    PubMed Central

    Nicholls, Thomas J.; Zsurka, Gábor; Peeva, Viktoriya; Schöler, Susanne; Szczesny, Roman J.; Cysewski, Dominik; Reyes, Aurelio; Kornblum, Cornelia; Sciacco, Monica; Moggio, Maurizio; Dziembowski, Andrzej; Kunz, Wolfram S.; Minczuk, Michal

    2014-01-01

    MGME1, also known as Ddk1 or C20orf72, is a mitochondrial exonuclease found to be involved in the processing of mitochondrial DNA (mtDNA) during replication. Here, we present detailed insights on the role of MGME1 in mtDNA maintenance. Upon loss of MGME1, elongated 7S DNA species accumulate owing to incomplete processing of 5′ ends. Moreover, an 11-kb linear mtDNA fragment spanning the entire major arc of the mitochondrial genome is generated. In contrast to control cells, where linear mtDNA molecules are detectable only after nuclease S1 treatment, the 11-kb fragment persists in MGME1-deficient cells. In parallel, we observed characteristic mtDNA duplications in the absence of MGME1. The fact that the breakpoints of these mtDNA rearrangements do not correspond to either classical deletions or the ends of the linear 11-kb fragment points to a role of MGME1 in processing mtDNA ends, possibly enabling their repair by homologous recombination. In agreement with its functional involvement in mtDNA maintenance, we show that MGME1 interacts with the mitochondrial replicase PolgA, suggesting that it is a constituent of the mitochondrial replisome, to which it provides an additional exonuclease activity. Thus, our results support the viewpoint that MGME1-mediated mtDNA processing is essential for faithful mitochondrial genome replication and might be required for intramolecular recombination of mtDNA. PMID:24986917

  12. Keeping mtDNA in Shape between Generations

    PubMed Central

    Stewart, James B.; Larsson, Nils-Göran

    2014-01-01

    Since the unexpected discovery that mitochondria contain their own distinct DNA molecules, studies of the mitochondrial DNA (mtDNA) have yielded many surprises. In animals, transmission of the mtDNA genome is explicitly non-Mendelian, with a very high number of genome copies being inherited from the mother after a drastic bottleneck. Recent work has begun to uncover the molecular details of this unusual mode of transmission. Many surprising variations in animal mitochondrial biology are known; however, a series of recent studies have identified a core of evolutionarily conserved mechanisms relating to mtDNA inheritance, e.g., mtDNA bottlenecks during germ cell development, selection against specific mtDNA mutation types during maternal transmission, and targeted destruction of sperm mitochondria. In this review, we outline recent literature on the transmission of mtDNA in animals and highlight the implications for human health and ageing. PMID:25299061

  13. Apprenticeship in France: Between Tradition and Innovation.

    ERIC Educational Resources Information Center

    Simon-Zarca, Georgie

    1996-01-01

    A study was made of the state of apprenticeship in France, using data gathered through telephone interviews with apprentices. Of a targeted group of 6,000 young apprentices, 70% participated in the survey. The study found that, until recently, apprenticeships had generally been used in France to train students in manual trades. During the past 10…

  14. 76 FR 56967 - Amendment of Class E Airspace; Glendive, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    .... * * * * * ANM MT E5 Glendive, MT Glendive, Dawson Community Airport, MT (Lat. 47 08'19'' N., long. 104 48'26'' W... extending upward from 1,200 feet above the surface within an area bounded by lat. 47 38'00'' N., long. 104 48'00'' W.; to lat. 47 17'00'' N., long. 104 05'00'' W.; to lat. 46 54'00'' N., long. 104 05'00''...

  15. Evolution of 3-mercaptohexanol, hydrogen sulfide, and methyl mercaptan during bottle storage of Sauvignon blanc wines. Effect of glutathione, copper, oxygen exposure, and closure-derived oxygen.

    PubMed

    Ugliano, Maurizio; Kwiatkowski, Mariola; Vidal, Stéphane; Capone, Dimitra; Siebert, Tracey; Dieval, Jean-Baptiste; Aagaard, Olav; Waters, Elizabeth J

    2011-03-23

    The effects of wine composition and postbottling oxygen exposure on 3-mercaptohexanol (3-MH), hydrogen sulfide (H2S), and methyl mercaptan (MeSH) were investigated. A Sauvignon blanc wine with initial copper concentration of 0.1 mg/L was treated with copper sulfate and/or glutathione (GSH) prior to bottling to give final concentrations of 0.3 and 20 mg/L, respectively. The wines were bottled with a synthetic closure previously stored in either ambient air or nitrogen to study the effect of the oxygen normally present in the closure. Bottled wines were stored for 6 months in either air or nitrogen to study the effect of oxygen ingress through the closure. Copper addition resulted in a rapid initial decrease in 3-MH. During storage, a further decrease of 3-MH was observed, which was lower with GSH addition and lowered oxygen exposure. H2S accumulated largely during the second 3 months of bottle storage, with the highest concentrations attained in the wines treated with GSH and copper. Lower oxygen from and through the closure promoted H2S accumulation. The concentration of MeSH was virtually not affected by the experimental variables at 6 months, although differences were observed after 3 months of storage. The implications for wine quality are discussed.

  16. Identification of S-3-(hexanal)-glutathione and its bisulfite adduct in grape juice from Vitis vinifera L. cv. Sauvignon blanc as new potential precursors of 3SH.

    PubMed

    Thibon, Cécile; Böcker, Caroline; Shinkaruk, Svitlana; Moine, Virginie; Darriet, Philippe; Dubourdieu, Denis

    2016-05-15

    Two main precursors (S-3-(hexan-1-ol)-l-cysteine and S-3-(hexan-1-ol)-l-glutathione) of 3-sulfanylhexanol (3SH, formerly named 3-mercaptohexanol) have been identified so far in grape juice but a correlation between precursor concentrations in grape juices and 3SH concentrations in wines is not always observed. This suggests that there may be other compounds associated with the aromatic potential. In this work, S-3-(hexanal)-glutathione (Glut-3SH-Al) and its bisulfite (Glut-3SH-SO3) adduct were identified in Sauvignon blanc grape juice by liquid chromatography coupled to Fourier transform mass spectrometry experiments. A partial purification of the compounds was carried out by Medium Pressure Liquid Chromatography (MPLC) on the reverse phase using 5L of grape juice. The addition of synthetized Glut-3SH-Al and Glut-3SH-SO3 in the synthetic medium induced a significant release of 3SH after fermentation. Moreover, we demonstrate that Glut-3SH-Al and its bisulfite adduct are present in grape juice and could be considered as new direct 3SH precursors with molar conversion yields close to 0.4%. Copyright © 2016. Published by Elsevier Ltd.

  17. 76 FR 35967 - Amendment of Class E Airspace; Bozeman, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... Bozeman, Gallatin Field Airport, Bozeman, MT, to accommodate aircraft using Instrument Landing System (ILS.... Controlled airspace is necessary to accommodate aircraft using the ILS LOC standard instrument...

  18. 77 FR 52219 - Amendment of Class E Airspace; Lewistown, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... aircraft using Area Navigation (RNAV) Global Positioning System (GPS) standard instrument approach... surface, at Lewistown Municipal Airport, Lewistown, MT, to accommodate IFR aircraft executing RNAV...

  19. [Surgical glove use in France].

    PubMed

    Caillot, J L

    2005-01-01

    Since the end of the 19th century, surgeons have used gloves to prevent infectious complications to the patient. The AIDS epidemic of the 1980's sparked the use of universal precautions to protect the surgeon from infection and vice-versa. The interface between surgeon and patient is in effect a two-way street. Surgical techniques must be modified and barrier protection optimized to minimize these risks. A single layer glove is a fragile barrier to blood exposure; unrecognized glove perforations may lead to unrecognized and prolonged exposure. Double gloving, though far from being a widespread practice in France, seems to be the best protection from pathogen exposure. Glove powder and latex allergies have their own inherent risks to both surgeon and patient in the form of latex allergies and adhesive peritonitis. New institutional protocols will be necesssary in order to make powder-free non-latex gloves available to French surgeons.

  20. Regulation of Biobanks in France.

    PubMed

    Rial-Sebbag, Emmanuelle; Pigeon, Anna

    2015-01-01

    The privacy of biobank research participants in France is protected by a combination of bioethics laws, research laws, and data protection laws. Although the law has attempted to facilitate research by creating an opt-out regime for research with pre-existing samples, other aspects of the law hinder research. The requirement for multiple consents throughout the process of biobank sample collection and use, the lack of acceptance of a broad consent for biobanking, and genetic exceptionalism in the law all complicate biobank research. With IRB approval, opt-out consent may be used for genetic research using human tissue collected for other purposes, but express consent is still required for research with the associated genetic data. Among the important issues remaining to be addressed are harmonizing and simplifying the various informed consent processes. © 2015 American Society of Law, Medicine & Ethics, Inc.

  1. WPA Omnibus Award MT Wind Power Outreach

    SciTech Connect

    Brian Spangler, Manager Energy Planning and Renewables

    2012-01-30

    The objective of this grant was to further the development of Montana's vast wind resources for small, medium, and large scale benefits to Montana and the nation. This was accomplished through collaborative work with wind industry representatives, state and local governments, the agricultural community, and interested citizens. Through these efforts MT Dept Environmental Quality (DEQ) was able to identify development barriers, educate and inform citizens, as well as to participate in regional and national dialogue that will spur the development of wind resources. The scope of DEQ's wind outreach effort evolved over the course of this agreement from the development of the Montana Wind Working Group and traditional outreach efforts, to the current focus on working with the state's university system to deliver a workforce trained to enter the wind industry.

  2. The Zn- and Cd-clusters of recombinant mammalian MT1 and MT4 metallothionein domains include sulfide ligands.

    PubMed

    Tío, Laura; Villarreal, Laura; Atrian, Sílvia; Capdevila, Mercè

    2006-10-01

    Recombinant (E. coli ) synthesis of mammalian MT1 and MT4 domains as separate peptides in Zn(II) and Cd(II) enriched growth media has rendered metal complexes containing sulfide anions as additional ligands. The Cd preparations show higher sulfide content than the Zn preparations. Also, the betaMT1 and betaMT4 fragments exhibit higher sulfide/peptide ratios than the respective alpha fragments. Titration of Zn3-betaMT1 with Cd(II) followed by addition of several sodium sulfide equivalents shows that the Cd(II)-betaMT1 species can incorporate sulfide ligands in vitro, with a concomitant evolution of their UV-vis and CD fingerprints to those characteristic of the Cd-S2- chromophores. Current results have also provided full understanding of previous data collected by this group in the characterization of the Cd-betaMT1 preparations obtained from large-scale fermentor synthesis by allowing identification of at least 2S2- ligands per Cd-betaMT1 species. Furthermore, the results here presented have revealed that synthesis of betaMT4 in Cd-supplemented cultures yielded Cd,S(2-)-containing clusters instead of the proposed heterometallic Zn,Cd-betaMT4 complexes. Finally, a global evaluation of our results suggests that the higher the Cu-thionein character of a MT peptide, the higher is its tendency to harbor nonproteic ligands (i.e., sulfide anions) when building divalent metal clusters, especially Cd-MT complexes.

  3. The mutation rate of the human mtDNA deletion mtDNA4977.

    PubMed

    Shenkar, R; Navidi, W; Tavaré, S; Dang, M H; Chomyn, A; Attardi, G; Cortopassi, G; Arnheim, N

    1996-10-01

    The human mitochondrial mutation mtDNA4977 is a 4,977-bp deletion that originates between two 13-bp direct repeats. We grew 220 colonies of cells, each from a single human cell. For each colony, we counted the number of cells and amplified the DNA by PCR to test for the presence of a deletion. To estimate the mutation fate, we used a model that describes the relationship between the mutation rate and the probability that a colony of a given size will contain no mutants, taking into account such factors as possible mitochondrial turnover and mistyping due to PCR error. We estimate that the mutation rate for mtDNA4977 in cultured human cells is 5.95 x 10(-8) per mitochondrial genome replication. This method can be applied to specific chromosomal, as well as mitochondrial, mutations.

  4. Effects of the Melatonin MT-1/MT-2 Agonist Ramelteon on Daytime Body Temperature and Sleep

    PubMed Central

    Markwald, Rachel R.; Lee-Chiong, Teofilo L.; Burke, Tina M.; Snider, Jesse A.; Wright, Kenneth P.

    2010-01-01

    Study Objectives: A reduction in core temperature and an increase in the distal-proximal skin gradient (DPG) are reported to be associated with shorter sleep onset latencies (SOL) and better sleep quality. Ramelteon is a melatonin MT-1/MT-2 agonist approved for the treatment of insomnia. At night, ramelteon has been reported to shorten SOL. In the present study we tested the hypothesis that ramelteon would reduce core temperature, increase the DPG, as well as shorten SOL, reduce wakefulness after sleep onset (WASO), and increase total sleep time (TST) during a daytime sleep opportunity. Design: Randomized, double-blind, placebo-controlled, cross-over design. Eight mg ramelteon or placebo was administered 2 h prior to a 4-h daytime sleep opportunity. Setting: Sleep and chronobiology laboratory. Participants: Fourteen healthy adults (5 females), aged (23.2 ± 4.2 y). Measurements and Results: Primary outcome measures included core body temperature, the DPG and sleep physiology (minutes of total sleep time [TST], wake after sleep onset [WASO], and SOL). We also assessed as secondary outcomes, proximal and distal skin temperatures, sleep staging and subjective TST. Repeated measures ANOVA revealed ramelteon significantly reduced core temperature and increased the DPG (both P < 0.05). Furthermore, ramelteon reduced WASO and increased TST, and stages 1 and 2 sleep (all P < 0.05). The change in the DPG was negatively correlated with SOL in the ramelteon condition. Conclusions: Ramelteon improved daytime sleep, perhaps mechanistically in part by reducing core temperature and modulating skin temperature. These findings suggest that ramelteon may have promise for the treatment of insomnia associated with circadian misalignment due to circadian sleep disorders. Citation: Markwald RR; Lee-Choing TL; Burke TM; Snider JA; Wright KP. Effects of the melatonin MT-1/MT-2 agonist ramelteon on daytime body temperature and sleep. SLEEP 2010;33(6):825-831 PMID:20550024

  5. An Evaluation Study of Community Services, Mt. San Antonio College.

    ERIC Educational Resources Information Center

    Lohr, Sue

    A study was conducted by the Community Services Department at Mt. San Antonio College (Mt. SAC) to evaluate participant satisfaction and suggestions for future direction for the department's comprehensive program of non-credit courses. A questionnaire was administered in class to 307 participants between April 1, and June 1, 1987, focusing on…

  6. An Evaluation Study of Community Services, Mt. San Antonio College.

    ERIC Educational Resources Information Center

    Lohr, Sue

    A study was conducted by the Community Services Department at Mt. San Antonio College (Mt. SAC) to evaluate participant satisfaction and suggestions for future direction for the department's comprehensive program of non-credit courses. A questionnaire was administered in class to 307 participants between April 1, and June 1, 1987, focusing on…

  7. 78 FR 67024 - Establishment of Class E Airspace; Glasgow, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Federal Aviation Administration 14 CFR Parts 71 Establishment of Class E Airspace; Glasgow, MT AGENCY... a final rule published in the Federal Register of September 30, 2013, that establishes Class E... aid, Glasgow, MT. A favorable comment from the National Business Aviation Association (NBAA)...

  8. SignMT: An Alternative Language Learning Tool

    ERIC Educational Resources Information Center

    Ditcharoen, Nadh; Naruedomkul, Kanlaya; Cercone, Nick

    2010-01-01

    Learning a second language is very difficult, especially, for the disabled; the disability may be a barrier to learn and to utilize information written in text form. We present the SignMT, Thai sign to Thai machine translation system, which is able to translate from Thai sign language into Thai text. In the translation process, SignMT takes into…

  9. Construct Validity of the MMPI-2 College Maladjustment (Mt) Scale

    ERIC Educational Resources Information Center

    Barthlow, Deanna L.; Graham, John R.; Ben-Porath, Yossef S.; McNulty, John L

    2004-01-01

    The construct validity of the MMPI-2 (Minnesota Multiphasic Personality Inventory-2) College Maladjustment (Mt) Scale was examined using 376 student clients at a university psychological clinic. A principal components analysis and correlations of Mt scale scores with clients' and therapists' ratings of symptoms and functioning showed that the Mt…

  10. 75 FR 41075 - Amendment of Class E Airspace; Bozeman, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Bozeman, MT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action will amend Class E airspace at... proposed rulemaking to amend Class E airspace at Bozeman, MT (75 FR 20321). Interested parties were...

  11. Interface Symbiotic Membrane Formation in Root Nodules of Medicago truncatula: the Role of Synaptotagmins MtSyt1, MtSyt2 and MtSyt3

    PubMed Central

    Gavrin, Aleksandr; Kulikova, Olga; Bisseling, Ton; Fedorova, Elena E.

    2017-01-01

    Symbiotic bacteria (rhizobia) are maintained and conditioned to fix atmospheric nitrogen in infected cells of legume root nodules. Rhizobia are confined to the asymmetrical protrusions of plasma membrane (PM): infection threads (IT), cell wall-free unwalled droplets and symbiosomes. These compartments rapidly increase in surface and volume due to the microsymbiont expansion, and remarkably, the membrane resources of the host cells are targeted to interface membrane quite precisely. We hypothesized that the change in the membrane tension around the expanding microsymbionts creates a vector for membrane traffic toward the symbiotic interface. To test this hypothesis, we selected calcium sensors from the group of synaptotagmins: MtSyt1, Medicago truncatula homolog of AtSYT1 from Arabidopsis thaliana known to be involved in membrane repair, and two other homologs expressed in root nodules: MtSyt2 and MtSyt3. Here we show that MtSyt1, MtSyt2, and MtSyt3 are expressed in the expanding cells of the meristem, zone of infection and proximal cell layers of zone of nitrogen fixation (MtSyt1, MtSyt3). All three GFP-tagged proteins delineate the interface membrane of IT and unwalled droplets and create a subcompartments of PM surrounding these structures. The localization of MtSyt1 by EM immunogold labeling has shown the signal on symbiosome membrane and endoplasmic reticulum (ER). To specify the role of synaptotagmins in interface membrane formation, we compared the localization of MtSyt1, MtSyt3 and exocyst subunit EXO70i, involved in the tethering of post-Golgi secretory vesicles and operational in tip growth. The localization of EXO70i in root nodules and arbusculated roots was strictly associated with the tips of IT and the tips of arbuscular fine branches, but the distribution of synaptotagmins on membrane subcompartments was broader and includes lateral parts of IT, the membrane of unwalled droplets as well as the symbiosomes. The double silencing of synaptotagmins

  12. Interface Symbiotic Membrane Formation in Root Nodules of Medicago truncatula: the Role of Synaptotagmins MtSyt1, MtSyt2 and MtSyt3.

    PubMed

    Gavrin, Aleksandr; Kulikova, Olga; Bisseling, Ton; Fedorova, Elena E

    2017-01-01

    Symbiotic bacteria (rhizobia) are maintained and conditioned to fix atmospheric nitrogen in infected cells of legume root nodules. Rhizobia are confined to the asymmetrical protrusions of plasma membrane (PM): infection threads (IT), cell wall-free unwalled droplets and symbiosomes. These compartments rapidly increase in surface and volume due to the microsymbiont expansion, and remarkably, the membrane resources of the host cells are targeted to interface membrane quite precisely. We hypothesized that the change in the membrane tension around the expanding microsymbionts creates a vector for membrane traffic toward the symbiotic interface. To test this hypothesis, we selected calcium sensors from the group of synaptotagmins: MtSyt1, Medicago truncatula homolog of AtSYT1 from Arabidopsis thaliana known to be involved in membrane repair, and two other homologs expressed in root nodules: MtSyt2 and MtSyt3. Here we show that MtSyt1, MtSyt2, and MtSyt3 are expressed in the expanding cells of the meristem, zone of infection and proximal cell layers of zone of nitrogen fixation (MtSyt1, MtSyt3). All three GFP-tagged proteins delineate the interface membrane of IT and unwalled droplets and create a subcompartments of PM surrounding these structures. The localization of MtSyt1 by EM immunogold labeling has shown the signal on symbiosome membrane and endoplasmic reticulum (ER). To specify the role of synaptotagmins in interface membrane formation, we compared the localization of MtSyt1, MtSyt3 and exocyst subunit EXO70i, involved in the tethering of post-Golgi secretory vesicles and operational in tip growth. The localization of EXO70i in root nodules and arbusculated roots was strictly associated with the tips of IT and the tips of arbuscular fine branches, but the distribution of synaptotagmins on membrane subcompartments was broader and includes lateral parts of IT, the membrane of unwalled droplets as well as the symbiosomes. The double silencing of synaptotagmins

  13. Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors

    PubMed Central

    Renzi, Anastasia; Glaser, Shannon; DeMorrow, Sharon; Mancinelli, Romina; Meng, Fanyin; Franchitto, Antonio; Venter, Julie; White, Mellanie; Francis, Heather; Han, Yuyan; Alvaro, Domenico; Gaudio, Eugenio; Carpino, Guido; Ueno, Yoshiyuki; Onori, Paolo

    2011-01-01

    In bile duct-ligated (BDL) rats, large cholangiocytes proliferate by activation of cAMP-dependent signaling. Melatonin, which is secreted from pineal gland as well as extrapineal tissues, regulates cell mitosis by interacting with melatonin receptors (MT1 and MT2) modulating cAMP and clock genes. In the liver, melatonin suppresses oxidative damage and ameliorates fibrosis. No information exists regarding the role of melatonin in the regulation of biliary hyperplasia. We evaluated the mechanisms of action by which melatonin regulates the growth of cholangiocytes. In normal and BDL rats, we determined the hepatic distribution of MT1, MT2, and the clock genes, CLOCK, BMAL1, CRY1, and PER1. Normal and BDL (immediately after BDL) rats were treated in vivo with melatonin before evaluating 1) serum levels of melatonin, bilirubin, and transaminases; 2) intrahepatic bile duct mass (IBDM) in liver sections; and 3) the expression of MT1 and MT2, clock genes, and PKA phosphorylation. In vitro, large cholangiocytes were stimulated with melatonin in the absence/presence of luzindole (MT1/MT2 antagonist) and 4-phenyl-2-propionamidotetralin (MT2 antagonist) before evaluating cell proliferation, cAMP levels, and PKA phosphorylation. Cholangiocytes express MT1 and MT2, CLOCK, BMAL1, CRY1, and PER1 that were all upregulated following BDL. Administration of melatonin to BDL rats decreased IBDM, serum bilirubin and transaminases levels, the expression of all clock genes, cAMP levels, and PKA phosphorylation in cholangiocytes. In vitro, melatonin decreased the proliferation, cAMP levels, and PKA phosphorylation, decreases that were blocked by luzindole. Melatonin may be important in the management of biliary hyperplasia in human cholangiopathies. PMID:21757639

  14. Developing equine mtDNA profiling for forensic application.

    PubMed

    Gurney, Susan M R; Schneider, Sandra; Pflugradt, René; Barrett, Elizabeth; Forster, Anna Catharina; Brinkmann, Bernd; Jansen, Thomas; Forster, Peter

    2010-11-01

    Horse mtDNA profiling can be useful in forensic work investigating degraded samples, hair shafts or highly dilute samples. Degraded DNA often does not allow sequencing of fragments longer than 200 nucleotides. In this study we therefore search for the most discriminatory sections within the hypervariable horse mtDNA control region. Among a random sample of 39 horses, 32 different sequences were identified in a stretch of 921 nucleotides. The sequences were assigned to the published mtDNA types A-G, and to a newly labelled minor type H. The random match probability within the analysed samples is 3.61%, and the average pairwise sequence difference is 15 nucleotides. In a "sliding window" analysis of 200-nucleotide sections of the mtDNA control region, we find that the known repetitive central motif divides the mtDNA control region into a highly diverse segment and a markedly less discriminatory segment.

  15. Spotlight on the relevance of mtDNA in cancer.

    PubMed

    Cruz-Bermúdez, A; Vicente-Blanco, R J; Gonzalez-Vioque, E; Provencio, M; Fernández-Moreno, M Á; Garesse, R

    2017-04-01

    The potential role of the mitochondrial genome has recently attracted interest because of its high mutation frequency in tumors. Different aspects of mtDNA make it relevant for cancer's biology, such as it encodes a limited but essential number of genes for OXPHOS biogenesis, it is particularly susceptible to mutations, and its copy number can vary. Moreover, most ROS in mitochondria are produced by the electron transport chain. These characteristics place the mtDNA in the center of multiple signaling pathways, known as mitochondrial retrograde signaling, which modifies numerous key processes in cancer. Cybrid studies support that mtDNA mutations are relevant and exert their effect through a modification of OXPHOS function and ROS production. However, there is still much controversy regarding the clinical relevance of mtDNA mutations. New studies should focus more on OXPHOS dysfunction associated with a specific mutational signature rather than the presence of mutations in the mtDNA.

  16. mtDNAprofiler: a Web application for the nomenclature and comparison of human mitochondrial DNA sequences.

    PubMed

    Yang, In Seok; Lee, Hwan Young; Yang, Woo Ick; Shin, Kyoung-Jin

    2013-07-01

    Mitochondrial DNA (mtDNA) is a valuable tool in the fields of forensic, population, and medical genetics. However, recording and comparing mtDNA control region or entire genome sequences would be difficult if researchers are not familiar with mtDNA nomenclature conventions. Therefore, mtDNAprofiler, a Web application, was designed for the analysis and comparison of mtDNA sequences in a string format or as a list of mtDNA single-nucleotide polymorphisms (mtSNPs). mtDNAprofiler which comprises four mtDNA sequence-analysis tools (mtDNA nomenclature, mtDNA assembly, mtSNP conversion, and mtSNP concordance-check) supports not only the accurate analysis of mtDNA sequences via an automated nomenclature function, but also consistent management of mtSNP data via direct comparison and validity-check functions. Since mtDNAprofiler consists of four tools that are associated with key steps of mtDNA sequence analysis, mtDNAprofiler will be helpful for researchers working with mtDNA. mtDNAprofiler is freely available at http://mtprofiler.yonsei.ac.kr.

  17. Napoli and Volcanism - Vesuvius and Mt. Etna

    NASA Technical Reports Server (NTRS)

    2002-01-01

    For more than 240 million years the region now known as Italy has been the scene of episodic volcanic activity. East-southeast of Napoli (Naples) stands the imposing cone of Vesuvius, which erupted explosively in 79 A.D. to bury Pompeii and Herculaneum. More recently, when the crew of Space Shuttle mission STS-104 captured this view, Mt. Etna (Sicily, not seen in this image, but photographed the day before) was spewing ash and gas thousands of meters into the air, some of which can be seen as a brownish smear over Isola d' Ischia and the Tyrrhenian Sea. The Appenine ranges extend from northern Italy, down the boot of the peninsula and westward into Sicily. This photograph of the Appenino Napoletano is part of an 18-frame stereophoto mapping strip that spans the entire mountain chain. The almost 1200-km-long belt of volcanoes and folded/faulted mountains is a result of the ongoing collision of Africa and Eurasia, accompanied by the progressive closing of the Mediterranean Sea. Using overlapping pairs of stereophotos, and a special viewer, scientists can get a three-dimensional perspective on the ranges that surpasses any image viewed alone. For more information, see another image of Mt. Vesuvius, taken by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER). References: Behncke, Boris, 2000, Vesuvio - The eruption of A.D. 79: Italy's Volcanoes - The Cradle of Volcanology [http://www.geo.mtu.edu/boris/VESUVIO_79.html (accessed 10/18/01)] Doglioni, C., and Flores, G., 1997, Italy, in Moores, E. M., and Fairbridge, R. W., editors, Encyclopedia of European and Asian Regional Geology: London, Chapman and Hall, p. 414-435 Shuttle photograph STS104-710-60 was taken 23 July 2001 from the orbiter Atlantis using a Hasselblad camera with 250-mm lens. The image is provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. The entire mapping series (of frames numbered in sequence from 50 through 68) can also be downloaded from the

  18. Napoli and Volcanism - Vesuvius and Mt. Etna

    NASA Technical Reports Server (NTRS)

    2002-01-01

    For more than 240 million years the region now known as Italy has been the scene of episodic volcanic activity. East-southeast of Napoli (Naples) stands the imposing cone of Vesuvius, which erupted explosively in 79 A.D. to bury Pompeii and Herculaneum. More recently, when the crew of Space Shuttle mission STS-104 captured this view, Mt. Etna (Sicily, not seen in this image, but photographed the day before) was spewing ash and gas thousands of meters into the air, some of which can be seen as a brownish smear over Isola d' Ischia and the Tyrrhenian Sea. The Appenine ranges extend from northern Italy, down the boot of the peninsula and westward into Sicily. This photograph of the Appenino Napoletano is part of an 18-frame stereophoto mapping strip that spans the entire mountain chain. The almost 1200-km-long belt of volcanoes and folded/faulted mountains is a result of the ongoing collision of Africa and Eurasia, accompanied by the progressive closing of the Mediterranean Sea. Using overlapping pairs of stereophotos, and a special viewer, scientists can get a three-dimensional perspective on the ranges that surpasses any image viewed alone. For more information, see another image of Mt. Vesuvius, taken by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER). References: Behncke, Boris, 2000, Vesuvio - The eruption of A.D. 79: Italy's Volcanoes - The Cradle of Volcanology [http://www.geo.mtu.edu/boris/VESUVIO_79.html (accessed 10/18/01)] Doglioni, C., and Flores, G., 1997, Italy, in Moores, E. M., and Fairbridge, R. W., editors, Encyclopedia of European and Asian Regional Geology: London, Chapman and Hall, p. 414-435 Shuttle photograph STS104-710-60 was taken 23 July 2001 from the orbiter Atlantis using a Hasselblad camera with 250-mm lens. The image is provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. The entire mapping series (of frames numbered in sequence from 50 through 68) can also be downloaded from the

  19. [Smoking in women in France].

    PubMed

    Hill, C

    1999-10-01

    Surveillance of smoking behavior and study of consequences of smoking on the health of the French population, and particularly the female population, is a public health priority. The amount of tobacco consumed can be determined from sales figures and from surveys. Globally, tobacco sales increased through 1985. According to the available surveys, the proportion of regular smokers has varied little as smoking rate has decreased in men and increased in women. The decrease occurred in all age groups for men and increased only in the 25-49 year age group for women. Smoking is the cause of 60,000 deaths per year in France, 57,000 in the male population and 3,000 in the female population. Despite reinforced legislation (The Veil and Evin laws) which is unfortunately poorly applied, tobacco consumption has not decreased greatly. Funding levels for anti-smoking campaigns are totally insignificant compared with the efforts of the tobacco industry to promote their products. However, the beneficial health effect of stopping smoking is truly great since the risk depends much more on the duration of smoking than on the number of daily cigarettes. In addition, the delay between the cause and consequence is long, the consequences of the increase in tobacco smoking among young women over the last 20 years will not become visible until 20 to 40 years from now. One could wonder why so little effort has been put into anti-smoking campaigns despite the readily available data clearly warranting their promotion.

  20. [Cannabis in France, new insights].

    PubMed

    Costentin, Jean

    2014-03-01

    France holds the record for cannabis use in Europe, especially among adolescents. This drug of abuse is thus mainly used during a very sensitive period of brain development, education, vehicle driving and development of life projects. In addition, synthetic derivatives of tetrahydrocannabinol (THC), which are more noxious than cannabis itself are now appearing on the market. Traficking and cultivation for personnal use have intensified; products proposed for sale are richer in THC; and some methods of consumption (e-cigarettes, vaporizers, water pipes) increase the supply of THC to the lungs and thence to the body and brain. It is in this context that attempts are being made to legalize this drug of abuse. Other attempts are made to disguise it as a medication. Meanwhile, the list of its psychic as well as physical damages grows longer, with some very severe cases of major injuries. This evolution takes place in spite of numerous warnings expressed by the French Academy of Medicine. Subsequently, it is prompted to carefully and vigorously denounce these events. This will be the aim of this thematic session.

  1. [Chronic respiratory insufficiency in France].

    PubMed

    Chailleux, E; Boffa, C

    2001-05-31

    The data concerning the prevalence of chronic respiratory insufficiency (CRI) in France are scarce: in 1994 official numbers were 14,000 deaths due to chronic bronchitis, 2,000 due to asthma for a total number of 40,000 deaths with respiratory cause; the same year 27,000 new patients were compensated for chronic respiratory insufficiency by social security services. On January 1st 2000 the non-profit organizations was in charge of 21,500 patients with long term oxygen therapy and 10,500 with home ventilation, and the commercial companies respectively 30,000 and 6,000. Accordingly the total of patients treated at home for CRI is about 68,000. The repartition by cause of CRI, the characteristics of patients and the prognosis can be evaluated thanks to the ANTADIR observatory which collects medical data since 1981. Chronic obstructive pulmonary diseases (chronic bronchitis, emphysema, asthma, bronchiectasis) count for more than half of the total of cases. Other causes comprise pleuro-parietal diseases (tuberculosis sequelae, kyphoscoliosis), neuro-muscular diseases and interstitial lung diseases. CRI is a severe disease with a survival median of three years for chronic obstructive pulmonary diseases, and a prognosis slightly better for kyphoscoliosis and neuro-muscular diseases, and worse for pulmonary fibrosis.

  2. Cold wake of Hurricane Frances

    NASA Astrophysics Data System (ADS)

    D'Asaro, Eric A.; Sanford, Thomas B.; Niiler, P. Peter; Terrill, Eric J.

    2007-08-01

    An array of instruments air-deployed ahead of Hurricane Frances measured the three-dimensional, time dependent response of the ocean to this strong (60 ms-1) storm. Sea surface temperature cooled by up to 2.2°C with the greatest cooling occurring in a 50-km-wide band centered 60-85 km to the right of the track. The cooling was almost entirely due to vertical mixing, not air-sea heat fluxes. Currents of up to 1.6 ms-1 and thermocline displacements of up to 50 m dispersed as near-inertial internal waves. The heat in excess of 26°C, decreased behind the storm due primarily to horizontal advection of heat away from the storm track, with a small contribution from mixing across the 26°C isotherm. SST cooling under the storm core (0.4°C) produced a 16% decrease in air-sea heat flux implying an approximately 5 ms-1 reduction in peak winds

  3. [The occupational physician in France].

    PubMed

    Matsuda, Shinya

    2013-10-01

    The French Labor law defines the role and its allocation criteria of the occupational physician (OP) the same as in Japan. In France, occupational medicine is one of the medical specialties. The OP resident must follow the 4 years clinical training before certification. After having finished their residency, they are entitled to work for the occupational health service office of a company or company association (in the case of small and medium sized companies). The most important characteristics of the French system is that they cover all workers regardless of company size. The main role of the OP is prevention of work related diseases and accidents. They are not allowed to do clinical services except for emergency cases. Their main activities are health examinations, health education, patrol and advice for better working condition. Formerly, it was rather difficult to attract the medical students for OP resident course because of its prevention oriented characteristics. A growing concern about the importance of health management at the work site, however, has changed the situation. Now, the number of candidates for OP resident course is increasing. Their task has expanded to cover mental health and other life style related diseases. The 2011 modification of law redefines the role of the OP as a director of an occupational health service office who has a total responsibility of multidisciplinary services. The French and Japanese occupational health systems have many of similarities. A comparative study by researchers of UOEH is expected to yield useful information.

  4. Mechanisms for the export of archaeal lipids down the water column in the upwelling area off Cape Blanc, North-West Africa

    NASA Astrophysics Data System (ADS)

    Ebersbach, Friederike; Goldenstein, Nadine; Iversen, Morten; Mollenhauer, Gesine; Hinrichs, Kai-Uwe

    2016-04-01

    Transport mechanisms of microbial membrane lipids from surface waters to the seafloor are poorly understood. In particular, pelagic archaeal glycerol dibiphytanyl glycerol tetraethers (GDGTs) from planktonic archaea are frequently used for reconstruction of ancient sea surface temperatures (Schouten et al. 2013). Because planktonic archaea are too small and neutrally buoyant to sink independently, transport vehicles for efficient export of fossil archaeal biomarkers to the sediment are required. The surface ocean is coupled with the deep ocean through biogenic sinking particles, a process known as the biological pump (Volk and Hoffert 1985). Two different pathways for particle formation, mainly taking place in the mesopelagic zone, are distinguished: Direct aggregation of phytoplankton blooms or grazing, resulting in phyto-detrital aggregates or reprocessed faecal material, respectively. Grazing and packaging into sinking particles is a possible export mechanism for GDGTs (Huguet et al. 2006). Moreover, it is assumed that phyto-detrital aggregates also play an important role in transporting GDGTs to the deep (Mollenhauer et al. 2015), but processes behind this pathway remain unclear. However, there are only few studies that link GDGT signals in sinking particles to the composition of the exported particulate matter (e.g. Yamamoto et al., 2012; Mollenhauer et al. 2015). Here we investigate sinking particles and suspended particulate matter (SPM) from spring blooms in 2012 and 2013 in the upwelling region in the Atlantic Ocean off Cape Blanc, Mauritania. We compare for the first time material from free-floating sediment traps (100, 200 and 400 m; purely sinking particles) with sinking particles and SPM from size fractionated in-situ pump (ISP) filters (several depths between 40 and 2350 m). This setup allows to relate the signal from archaeal lipids to (i) the flux of particulate organic carbon and the particle assemblages as revealed by the characterisation of

  5. 75 FR 16839 - Sorbitol From France

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Sorbitol From France AGENCY: United States International Trade Commission. ACTION: Revised schedule for the subject review. DATES: Effective Date: Date of Commission approval. FOR...

  6. New environmental technology options in France

    SciTech Connect

    Oppeneau, J.C. )

    1994-12-01

    Since the 1980s and the 1992 United Nations Conference on Environment and Development, the environmental, or ''ecological,'' dimension has become the basis for a strategic orientation among industries and economies. France in 1992 allocated nearly 100.5 billion French francs ($19 billion)--1.4 percent of its gross domestic products--to environmental protection. If drinking water production facilities, natural resource conservation, urban amenities and waste recycling are included, France's expenditure on the environment is almost 140 billion francs ($26.4 billion), or 1.8 percent of GDP. Despite a recessionary period, environmental expenditures increased about 2.4 percent in 1992, while industrial investment remained constant. Traditional industry's share in this national expenditure has reached 30 percent.

  7. Women's Employment in France: Protection or Equality.

    ERIC Educational Resources Information Center

    Devaud, Marcelle; Levy, Martine

    1980-01-01

    Reviews the origin and evolution of special protection laws in France for employed women, describes those measures that still exist, and explains what employers, unions, and the authorities think of them. Discusses pregnancy, family responsibilities, and technological progress. (CT)

  8. Demoiselles and Drafts from Italy and France.

    ERIC Educational Resources Information Center

    Picard, M. Dane

    1988-01-01

    Recounts the adventures of a journey taken through France and Italy. Makes an analogy of this trip to that of the one Charles Dickens took in 1844. Describes silicified horizons of the southern Paris Basin, moraines, outcrops, and "Hoodoos." (RT)

  9. The matter of preservation: A comparison of recent organic-walled dinoflagellate cyst assemblages in sediment trap and core top sediments off Cape Blanc (NW Africa)

    NASA Astrophysics Data System (ADS)

    Rüßbült, Annegret; Zonneveld, Karin A. F.; Pospelova, Vera

    2017-04-01

    During the last decades, organic-walled dinoflagellate cysts (dinocysts) have become a valuable tool for paleoenvironmental reconstructions. It is known that the sedimentary record depends on several factors like initial cyst production and preservation. Therefore it is necessary to know, to what extent the assemblage in the sediment reflects the primary signal produced in the water column. In this study, we compare undisturbed core top sediments with sediment trap data covering the same time intervals. Both, core and trap, were retrieved at a similar location off Cape Blanc (NW Africa) where high productivity of organic material takes place due to costal upwelling. The samples of trap CBi analyzed for dinocysts were collected over 5 years (2003-2008) and compared to assemblages found in 2 mm interval sections of core GeoB 14103-7. 210Pb dating revealed an age of 2.5 years per core sample, leading to a comparison of the upper 6 mm with CBi 1-5. The dinocyst species composition in core and trap sediments is similar. Both assemblages are dominated by heterotrophic species. However, while the most common species in the trap, Brigantidinium spp., makes up over 50% of each sample, it is less abundant in the core where it forms only 13% of the assemblage. Core samples are dominated by Protoperidinium monospinum with an average of 28%. This species is underrepresented in CBi with 3% abundance. Over time the proportions of the individual species show minor variations both in core and trap samples. We therefore assume that the strong differences in association composition are due to post-depositional processes altering the assemblages in the sediments like degradation or bioturbation rather than to changes in initial cyst production or differences in source areas of trap and sediment core.

  10. Tracking Holocene glacial and high-altitude alpine environments fluctuations from minerogenic and organic markers in proglacial lake sediments (Lake Blanc Huez, Western French Alps)

    NASA Astrophysics Data System (ADS)

    Simonneau, Anaëlle; Chapron, Emmanuel; Garçon, Marion; Winiarski, Thierry; Graz, Yann; Chauvel, Catherine; Debret, Maxime; Motelica-Heino, Mickaël; Desmet, Marc; Di Giovanni, Christian

    2014-04-01

    Holocene palaeoenvironmental evolution and glacial fluctuations at high-altitude in the western French Alps are reconstructed based on a multiproxy approach within Lake Blanc Huez (2550 m a.s.l.) drainage basin. The combination of seismic profiling (3.5 kHz), piston coring and radiocarbon dating in proglacial lacustrine sediments together with a detailed organic analysis of autochthonous and allochthonous supply allows documenting the evolution of glacier activity during the Holocene. Over the last 9700 years, the Holocene lake record has a bimodal pattern whose transition is progressive and occurring between 5400 and 4700 cal BP. During the Early Holocene, the organic lacustrine facies reflects reduced glacial activity in the catchment. This major glacial retreat seems to result from solar forcing and high summer insolation. After 5400 cal BP, lacustrine sedimentation is marked by the gradual increase both of minerogenic supply and soil erosion, suggesting a progressive transition to wetter climatic conditions. This climate change is synchronous both from the gradual decrease of summer insolation and the gradual reorganization of oceanic and atmospheric circulations, characterizing the beginning of the Neoglacial period. Both colder temperature and humid climate induced significant glacier advance, since 4700 cal BP. Over this global trend, three periods are particularly associated with higher runoff processes and higher soil erosion interpreted as wetter time intervals resulting from enhanced northern Westerlies regimes across the North Atlantic and Western Europe. They are dated from 8700 to 7000, 4700 to 2500 and 1200 to 200 cal BP. These wetter phases drastically contrast with periods of reduced glacial activities dated from the Early Bronze Age (ca 3870-3770 cal BP), the Iron Age (ca 2220-2150 cal BP), the Roman period (ca AD115-330) and the Medieval Warm Period (ca AD760-1160). In addition, these dryer periods are associated with mining activities at high-altitude.

  11. The Evolution of Minehunting in France (L’Evolution de la Chasse aux Mines en France),

    DTIC Science & Technology

    1983-07-13

    AD-A132 532 THE EVOLUTION OF MINEHUNTING IN FRANCE IL’EVOLUTION DE I/1 LA CHASSE AUX MINES EN FRANCE)(U) NAVAL INTELLIGENCE SUPPORT CENTER WASHINGTON...SEP 16 0 -wm- a/or.’- i.,it ______ D a " THE EVOLUTION OF MINEHUNTING IN FRANCE (de Drezigue, Cdr; L’Evolution de la Chasse aux Mines en France...than the minehunter could assure this mission? Evolution of Minehunting The guiding thought of this evolution is the following: to have a good

  12. [Smoking and electronic cigarettes in France].

    PubMed

    Berlin, Ivan

    2016-12-01

    France is one of the developed countries where the prevalence of tobacco use is the highest. The reduction of incidence and prevalence of tobacco use in the near future would considerably decrease tobacco associated mortality and morbidity. The electronic cigarette, a consumer product that delivers pharmacologically active substances, is used by several millions of persons in France. The benefit-risk ratio of electronic cigarette use is unknown, as of today.

  13. Surface and thickness variations of Brenva Glacier tongue (Mont Blanc, Italian Alps) in the second half of the 20th century by historical maps and aerial photogrammetry comparisons

    NASA Astrophysics Data System (ADS)

    D Agata, C.; Zanutta, A.; Muzzu Martis, D.; Mancini, F.; Smiraglia, C.

    2003-04-01

    Aim of this contribution is the evaluation of volumetric and surface variations of Brenva Glacier (Mont Blanc, Italian Alps) during the second half of the 20th century, by GIS-based processing of maps and aerial photogrammetry technique. Brenva Glacier is a typical debris covered glacier, located in a valley on the S-E side of the Mont Blanc. The glacier covers a surface of 7 kmq and shows a length of 7,6 km at maximum. The glacier snout reaches 1415 m a.s.l., which is the lowest glacier terminus of the Italian Alps. To evaluate glacier variations different historical maps were used: 1) The 1959 Map, at the scale 1:5.000, by EIRA (Ente Italiano Rilievi Aerofotogrammetrici, Firenze), from terrestrial photogrammetric survey, published in the Bollettino del Comitato Glaciologico Italiano, 2, n. 19, 1971. 2) The 1971 Map, at the scale 1:5.000, from aerial photogrammetry (Alifoto, Torino) published in the Bollettino del Comitato Glaciologico Italiano, 2, n. 20, 1972. 3) The 1988 Map, at the scale 1:10.000, (Region Aosta Valley, Regional Technical Map) from 1983 aerial photogrammetric survey. 4) The 1999 Map, at the scale 1:10.000, (Region Aosta Valley, Regional Technical Map) from 1991 aerial photogrammetry survey. For the same purpose the following aereal photographs were used: 1) The 1975 image, CGR (Italian General Company aerial Surveys) flight RAVDA (Administrative Autonomous Region Aosta Valley), at the scale 1:17.000. 2) The 1991 image, CGR (Italian General Company aerial Surveys) flight RAVDA (Administrative Autonomous Region Aosta Valley), at the scale 1:17.000. Aerial imageries have been acquired over a long period from 1975 to 1991. The black and white images were scanned at suitable resolution if compared with the imagery scale and several models, representing the glacier tongue area, oriented using the inner and outer orientation parameters delivered with the images, were produced. The digital photogrammetric system, after orientation and matching, produces

  14. Extreme mtDNA divergences in a terrestrial slug (Gastropoda, Pulmonata, Arionidae): accelerated evolution, allopatric divergence and secondary contact.

    PubMed

    Pinceel, J; Jordaens, K; Backeljau, T

    2005-09-01

    Extremely high levels of intraspecific mtDNA differences in pulmonate gastropods have been reported repeatedly and several hypotheses to explain them have been postulated. We studied the phylogeny and phylogeography of 51 populations (n = 843) of the highly polymorphic terrestrial slug Arion subfuscus (Draparnaud, 1805) across its native distribution range in Western Europe. By combining the analysis of single stranded conformation polymorphisms (SSCP) and nucleotide sequencing, we obtained individual sequence data for a fragment of the mitochondrial 16S rDNA and a fragment of the nuclear ITS1. Additionally, five polymorphic allozyme loci were scored. Based on the 16S rDNA phylogeny, five monophyletic haplotype groups with sequence divergences of 9-21% were found. Despite this deep mitochondrial divergence, the haplotype groups were not monophyletic for the nuclear ITS1 fragment and haplotype group-specific allozyme alleles were not found. Although there is evidence for an accelerated mtDNA clock, the divergence among the haplotype groups is older than the Pleistocene and their current allopatric ranges probably reflect allopatric divergence and glacial survival in separate refugia from which different post-glacial colonization routes were established. A range-overlap of two mtDNA groups (S1 and S2, 21% sequence divergence) stretched from Central France and Belgium up to the North of the British Isles. The nuclear data suggest that this secondary contact resulted in hybridization between the allopatrically diverged groups. Therefore, it seems that, at least for two of the groups, the deep mtDNA divergence was only partially accompanied by the formation of reproductive isolation.

  15. MT3DMS: Model use, calibration, and validation

    USGS Publications Warehouse

    Zheng, C.; Hill, Mary C.; Cao, G.; Ma, R.

    2012-01-01

    MT3DMS is a three-dimensional multi-species solute transport model for solving advection, dispersion, and chemical reactions of contaminants in saturated groundwater flow systems. MT3DMS interfaces directly with the U.S. Geological Survey finite-difference groundwater flow model MODFLOW for the flow solution and supports the hydrologic and discretization features of MODFLOW. MT3DMS contains multiple transport solution techniques in one code, which can often be important, including in model calibration. Since its first release in 1990 as MT3D for single-species mass transport modeling, MT3DMS has been widely used in research projects and practical field applications. This article provides a brief introduction to MT3DMS and presents recommendations about calibration and validation procedures for field applications of MT3DMS. The examples presented suggest the need to consider alternative processes as models are calibrated and suggest opportunities and difficulties associated with using groundwater age in transport model calibration.

  16. Viscosity controlled magma-carbonate interaction: a comparison of Mt. Vesuvius (Italy) and Mt. Merapi (Indonesia).

    NASA Astrophysics Data System (ADS)

    Blythe, L. S.; Misiti, V.; Masotta, M.; Taddeucci, J.; Freda, C.; Troll, V. R.; Deegan, F. M.; Jolis, E. M.

    2012-04-01

    Magma-carbonate interaction is increasingly seen as a viable and extremely important cause of magma contamination, and the generation of a crustally sourced CO2 phase (Goff et al., 2001; Freda et al., 2010). Even though the process is well recognized at certain volcanoes e.g. Popocatépetl, (Mexico); Merapi, (Indonesia); and Colli Albani, (Italy) (Goff et al., 2001; Deegan et al., 2010; Freda et al., 2010), neither the kinetics of carbonate assimilation nor its consequences for controlling the explosivity of eruptions have been constrained. Here we show the results of magma-carbonate interaction experiments conducted at 1200 °C and 0.5 GPa for varying durations (0 s, 60 s, 90 s and 300 s) for the Mt. Merapi (Indonesia) and Mt. Vesuvius (Italy) volcanic systems. We performed experiments using glassy starting materials specific to each volcano (shoshonite for Mt. Vesuvius, basaltic-andesite for Mt. Merapi) with different degrees of hydration (anhydrous vs hydration with ~ 2 wt % water) and using carbonate fragments of local origin; see Deegan et al., (2010) and Jolis et al., (2011). Experimental products include a gas phase (CO2-rich) and two melt phases, one pristine (Ca-normal) and one contaminated (Ca-rich) separated by a 'contamination front' which propagates outwards from the carbonate clast. Vesicles appear to nucleate in the contaminated glass and then migrate into the pristine one. Both contamination front propagation and bubble migration away from the carbonate are slower in anhydrous basaltic-andesite (Merapi anhydrous series) than in hydrated basaltic-andesite and shoshonite (Merapi and Vesuvius hydrated series), suggesting that assimilation speed is strongly controlled by the degree of hydration and the SiO2 content, both of which influence melt viscosity and hence diffusivity. As the carbonate dissolution proceeds in our experiments, initially dissolved and eventually exsolved CO2 builds up in the contaminated Ca-rich melt phase. Once melt volatile

  17. Comparison of complementary reactions in the production of Mt

    SciTech Connect

    Nelson, S. L.; Dragojevic, I.; Ellison, P. A.; Garcia, M. A.; Gates, J. M.; Nitsche, H.; Gregorich, K. E.; Dvorak, J.; Stavsetra, L.; Ali, M. N.

    2009-02-15

    The new reaction {sup 208}Pb({sup 59}Co,n){sup 266}Mt was studied using the Berkeley Gas-filled Separator at the Lawrence Berkeley National Laboratory 88-Inch Cyclotron. A cross section of 7.7{sub -3.3}{sup +5.2} pb was measured at a compound nucleus excitation energy of 14.9 MeV. The measured decay properties of {sup 266}Mt and its daughters correspond well with existing data. We compare this experimental result to transactinide compound nucleus formation model predictions, and the previously studied {sup 209}Bi({sup 58}Fe,n){sup 266}Mt reaction.

  18. Comparison of Complementary Reactions in the Production of Mt

    SciTech Connect

    Nelson, Sarah; Gregorich, Kenneth; Dragojevic, Irena; Ellison, Paul; Garcia, Mitch Andre; Gates, Jacklyn; Stavsetra, Liv; Ali, Mazhar; Nitsche, Heino

    2009-01-21

    The new reaction 208Pb(59Co,n)266Mt was studied using the Berkeley Gas-filled Separator at the Lawrence Berkeley National Laboratory 88-Inch Cyclotron. A cross section of 7.7+5.2-3.3 pb was measured at a compound nucleus excitation energy of 14.9 MeV. The measured decay properties of 266Mt and its daughters correspond well with existing data. We compare this experimental result to transactinide compound nucleus formation model predictions, and the previously studied 209Bi(58Fe,n)266Mt reaction.

  19. Stoichiometric expression of mtHsp40 and mtHsp70 modulates mitochondrial morphology and cristae structure via Opa1L cleavage.

    PubMed

    Lee, Byoungchun; Ahn, Younghee; Kang, Sung-Myung; Park, Youngjin; Jeon, You-Jin; Rho, Jong M; Kim, Sung-Woo

    2015-06-15

    Deregulation of mitochondrial heat-shock protein 40 (mtHsp40) and dysfunction of mtHsp70 are associated with mitochondrial fragmentation, suggesting that mtHsp40 and mtHsp70 may play roles in modulating mitochondrial morphology. However, the mechanism of mitochondrial fragmentation induced by mtHsp40 deregulation and mtHsp70 dysfunction remains unclear. In addition, the functional link between mitochondrial morphology change upon deregulated mtHsp40/mtHsp70 and mitochondrial function has been unexplored. Our coimmunoprecipitation and protein aggregation analysis showed that both overexpression and depletion of mtHsp40 accumulated aggregated proteins in fragmented mitochondria. Moreover, mtHsp70 loss and expression of a mtHsp70 mutant lacking the client-binding domain caused mitochondrial fragmentation. Together the data suggest that the molecular ratio of mtHsp40 to mtHsp70 is important for their chaperone function and mitochondrial morphology. Whereas mitochondrial translocation of Drp1 was not altered, optic atrophy 1 (Opa1) short isoform accumulated in fragmented mitochondria, suggesting that mitochondrial fragmentation in this study results from aberration of mitochondrial inner membrane fusion. Finally, we found that fragmented mitochondria were defective in cristae development, OXPHOS, and ATP production. Taken together, our data suggest that impaired stoichiometry between mtHsp40 and mtHsp70 promotes Opa1L cleavage, leading to cristae opening, decreased OXPHOS, and triggering of mitochondrial fragmentation after reduction in their chaperone function.

  20. Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs

    PubMed Central

    Gammage, Payam A.; Gaude, Edoardo; Van Haute, Lindsey; Rebelo-Guiomar, Pedro; Jackson, Christopher B.; Rorbach, Joanna; Pekalski, Marcin L.; Robinson, Alan J.; Charpentier, Marine; Concordet, Jean-Paul; Frezza, Christian; Minczuk, Michal

    2016-01-01

    Mitochondrial diseases are frequently associated with mutations in mitochondrial DNA (mtDNA). In most cases, mutant and wild-type mtDNAs coexist, resulting in heteroplasmy. The selective elimination of mutant mtDNA, and consequent enrichment of wild-type mtDNA, can rescue pathological phenotypes in heteroplasmic cells. Use of the mitochondrially targeted zinc finger-nuclease (mtZFN) results in degradation of mutant mtDNA through site-specific DNA cleavage. Here, we describe a substantial enhancement of our previous mtZFN-based approaches to targeting mtDNA, allowing near-complete directional shifts of mtDNA heteroplasmy, either by iterative treatment or through finely controlled expression of mtZFN, which limits off-target catalysis and undesired mtDNA copy number depletion. To demonstrate the utility of this improved approach, we generated an isogenic distribution of heteroplasmic cells with variable mtDNA mutant level from the same parental source without clonal selection. Analysis of these populations demonstrated an altered metabolic signature in cells harbouring decreased levels of mutant m.8993T>G mtDNA, associated with neuropathy, ataxia, and retinitis pigmentosa (NARP). We conclude that mtZFN-based approaches offer means for mtDNA heteroplasmy manipulation in basic research, and may provide a strategy for therapeutic intervention in selected mitochondrial diseases. PMID:27466392

  1. Zinc metallothionein (MT) induction by parenteral iron and endotoxin: A temporal analysis of hepatic MT mRNA changes

    SciTech Connect

    McCormick, C.C. )

    1991-03-15

    The present study was undertaken to compare the temporal characteristics of iron-induced hepatic MT mRNA accumulation to that effected by endotoxin. Young chicks were given (ip) either endotoxin, ferrous gluconate or an equivalent volume of saline. At various times following injections, liver was obtained from 5 chicks per treatment for total RNA extraction. Equal amounts of total hepatic RNA from each chick were pooled and 10 {mu}g separated by denaturing agarose gel electrophoresis. Hepatic MT mRNA and albumin mRNA were analyzed by Northern blot analysis using synthetic oligonucleotides. The results indicated little temporal difference in the accumulation of hepatic MT mRNA as affected by either endotoxin or iron. In both treatments, MT mRNA was minimally affected at 3 hours post-injection. Maximum accumulation was achieved during a 6 h period from 6 to 12 hours post-injection. At 24 hours, MT mRNA was considerably higher in liver of endotoxin-injected chicks when compared to that of iron-injection chicks. Albumin expression appeared not to be substantially affected by either treatment. The results suggest that the induction of hepatic MT by iron injection is not substantially different than that observed following endotoxin administration. It would be speculative to suggest that the processes by which MT is induced under these conditions are also similar.

  2. Porous aerosol in degassing plumes of Mt. Etna and Mt. Stromboli

    NASA Astrophysics Data System (ADS)

    Shcherbakov, Valery; Jourdan, Olivier; Voigt, Christiane; Gayet, Jean-Francois; Chauvigne, Aurélien; Schwarzenboeck, Alfons; Minikin, Andreas; Klingebiel, Marcus; Weigel, Ralf; Borrmann, Stephan; Jurkat, Tina; Kaufmann, Stefan; Schlage, Romy; Gourbeyre, Christophe; Febvre, Guy; Lapyonok, Tatyana; Frey, Wiebke; Molleker, Sergej; Weinzierl, Bernadett

    2016-09-01

    Aerosols of the volcanic degassing plumes from Mt. Etna and Mt. Stromboli were probed with in situ instruments on board the Deutsches Zentrum für Luft- und Raumfahrt research aircraft Falcon during the contrail, volcano, and cirrus experiment CONCERT in September 2011. Aerosol properties were analyzed using angular-scattering intensities and particle size distributions measured simultaneously with the Polar Nephelometer and the Forward Scattering Spectrometer probes (FSSP series 100 and 300), respectively. Aerosols of degassing plumes are characterized by low values of the asymmetry parameter (between 0.6 and 0.75); the effective diameter was within the range of 1.5-2.8 µm and the maximal diameter was lower than 20 µm. A principal component analysis applied to the Polar Nephelometer data indicates that scattering features of volcanic aerosols of different crater origins are clearly distinctive from angular-scattering intensities of cirrus and contrails. Retrievals of aerosol properties revealed that the particles were "optically spherical" and the estimated values of the real part of the refractive index are within the interval from 1.35 to 1.38. The interpretation of these results leads to the conclusion that the degassing plume aerosols were porous with air voids. Our estimates suggest that aerosol particles contained about 18 to 35 % of air voids in terms of the total volume.

  3. Eudialyte-group minerals in rocks of Lovozero layered complex at Mt. Karnasurt and Mt. Kedykvyrpakhk

    NASA Astrophysics Data System (ADS)

    Ivanyuk, G. Yu.; Pakhomovsky, Ya. A.; Yakovenchuk, V. N.

    2015-12-01

    Eudialyte-bearing interbeds within layers I-4 (Mt. Karnasurt) and II-4 (Mt. Kedykvyrpakhk) in the layered complex of the Lovozero Pluton are localized symmetrically relative to the loparite-bearing ijolite-malignite layer; the content of eudialyte decreases from underlying nepheline syenite to overlying foidolite. Eudialyte-group minerals fill the interstices between nepheline, sodalite, and microcline-perthite crystals in all rock types and are partially replaced with georgechaoite and minerals of the lovozerite group as a result of hydrothermal alteration. Variations in the chemical composition of the eudialyte-group minerals are mainly controlled by block substitution NaFeZrCl ↔ LnMn(Nb,Ti)S producing eudialyte proper, manganoeudialyte (sharply predominant), kentbrooksite, alluaivite, and a phase intermediate between manganoeudialyte and alluaivite. As the total Ln2O3 content increases, the relative amounts of Ce and La oxides increases linearly in the proportion Ce2O3: La2O3 = 2.5: 1. In the phases containing lower than 3 wt % La2O3, Nd becomes the next REE after Ce. It is very likely that (mangano)eudialyte was mostly formed after parakeldyshite and other anhydrous zirconium-silicate under effect of residual fluids enriched in Ca and Mn, which took part in fenitization of basalt, tuff, and tuffite of the Lovozero Formation.

  4. Loparite-(Ce) in rocks of the Lovozero layered complex at Mt. Karnasurt and Mt. Kedykvyrpakhk

    NASA Astrophysics Data System (ADS)

    Pakhomovsky, Ya. A.; Ivanyuk, G. Yu.; Yakovenchuk, V. N.

    2014-12-01

    Following from a mineralogical and petrographic study of loparite-bearing units I-4 at Mt. Karnasurt and II-4 at Mt. Kedykvyrpakhk, loparite-(Ce) is found to be concentrated in thin (10-40 cm) malignite-ijolite layers at the boundary between the underlying nepheline syenite and the overlying foidolite. Skeletal loparite-(Ce) metacrysts occur as inclusions in nepheline, sodalite, natrolite, aegirine, eudialyte, and lomonosovite or within the intergranular space between them. In turn, the characteristic segregations of skeletal loparite-(Ce) metacrysts contain inclusions of natrolite, lomonosovite, rhabdophane-(Ce), labuntsovite, and other relatively low-temperature minerals typical of pegmatites and hydrothermally altered rocks. The chemical composition of loparite-(Ce) varies within narrow limits (Lop59-70Per11-18Lue5-11Tsn4-7 due to an increase in Ca, Ln, Al, and Ti contents and a decrease in Na, Mn, Th, Sr, Fe, and Ta contents in the transitional zone between the underlying nepheline syenite, ore-bearing foidolite-malignite, and overlying ijoliteurtite. Variations in composition are also caused by the lateral isomorphic replacement of Na and Nb with Ln and Ti. The data obtained show that loparite mineralization is related to a pneumatolytic-hydrothermal alteration of foidolite and nepheline syenite along the contact between them.

  5. Altered MT1 and MT2 melatonin receptors expression in the hippocampus of pilocarpine-induced epileptic rats.

    PubMed

    Rocha, Anna Karynna Alves de Alencar; de Lima, Eliangela; Amaral, Fernanda; Peres, Rafael; Cipolla-Neto, José; Amado, Débora

    2017-06-01

    Clinical and experimental findings show that melatonin may be used as an adjuvant to the treatment of epilepsy-related complications by alleviates sleep disturbances, circadian alterations and attenuates seizures alone or in combination with AEDs. In addition, it has been observed that there is a circadian component on seizures, which cause changes in circadian system and in melatonin production. Nevertheless, the dynamic changes of the melatoninergic system, especially with regard to its membrane receptors (MT1 and MT2) in the natural course of TLE remain largely unknown. The aim of this study was to evaluate the 24-hour profile of MT1 and MT2 mRNA and protein expression in the hippocampus of rats submitted to the pilocarpine-induced epilepsy model analyzing the influence of the circadian rhythm in the expression pattern during the acute, silent, and chronic phases. Melatonin receptor MT1 and MT2 mRNA expression levels were increased in the hippocampus of rats few hours after SE, with MT1 returning to normal levels and MT2 reducing during the silent phase. During the chronic phase, mRNA expression levels of both receptors return to levels close to control, however, presenting a different daily profile, showing that there is a circadian change during the chronic phase. Also, during the acute and silent phase it was possible to verify MT1 label only in CA2 hippocampal region with an increased expression only in the dark period of the acute phase. The MT2 receptor was present in all hippocampal regions, however, it was reduced in the acute phase and it was found in astrocytes. In chronic animals, there is a reduction in the presence of both receptors especially in regions where there is a typical damage derived from epilepsy. Therefore, we conclude that SE induced by pilocarpine is able to change melatonin receptor MT1 and MT2 protein and mRNA expression levels in the hippocampus of rats few hours after SE as well as in silent and chronic phases. Copyright © 2017

  6. Advanced MCT technologies in France

    NASA Astrophysics Data System (ADS)

    Destefanis, Gérard; Tribolet, Philippe

    2007-04-01

    In this paper we present an overview of the very recent developments of the HgCdTe infrared detector technology developed by CEA-LETI and industrialized by Sofradir in France. Today Sofradir uses in production for more than 15years a very mature, reproducible, well mastered and fully understood, planar n on p ion implanted technology. This process that allows very high yields to be achieved in all infrared bands from SWIR to LWIR uses the very conventional approach of LPE growth of MCT on lattice-matched CdZnTe substrates. Progress in this field is continuous from 20years and has recently leaded to the fabrication of high performance VLWIR FPA (320x256 with cut off wavelengths as high as 20μm). Moreover, thanks to the design of the epitaxial structure and to the substrate removal step MCT FPAs present the unique features to have very high quantum efficiency (above 70%) from the cut off wavelength down to the UV. This effect, which opens new application fields, was recently demonstrated in SWIR 320x256 FPAs with cut off wavelength of 2.5μm. Very high quality FPAs (1280x1024) with pitches as small as 15μm have already been demonstrated last year using the MBE growth of MWIR MCT epilayers on 4 inches germanium substrates, n on p ion implanted photodiodes and the hot welding indium bump hybridization technique. At the same time, with the MBE growth, bicolor and dual band FPAs which uses more complex multi hetero-junctions architectures (both 4 layers npn and 'pseudo planar' structures and extrinsically doped MCT layers) were fabricated with formats of 320x256 and pitches as small as 25μm. A very new area of development concerns avalanche photodiodes (APD) made with MCT. This semiconductor presents a unique feature among all the over semiconductors. Extremely high avalanche gains can be obtained on n on p photodiodes without absolutely any noise excess (F(K)=1): MCT APDs act as perfect amplifiers. These results open new interesting fields of investigation for low

  7. RadNet Air Data From Kalispell, MT

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Kalispell, MT from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  8. RadNet Air Data From Billings, MT

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Billings, MT from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  9. Mt. Etna, Italy taken by the Expedition Two crew

    NASA Image and Video Library

    2001-07-22

    ISS002-E-8683 (22 July 2001) --- Smoke and ash combine to create a plume extending from the erupting volcano on Mt. Etna in Sicily. The digital still image was recorded by one of the Expedition Two crew members.

  10. 75 FR 54419 - Environmental Impact Statement: Yellowstone County, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ... Federal Highway Administration Environmental Impact Statement: Yellowstone County, MT AGENCY: Federal... highway project in Yellowstone County, Montana. FOR FURTHER INFORMATION CONTACT: Brian Hasselbach, Right... (I-90) and Old Highway 312 in or near the city of Billings, Yellowstone County, Montana....

  11. 76 FR 27914 - Television Broadcasting Services; Kalispell, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 Television Broadcasting Services; Kalispell, MT AGENCY: Federal Communications Commission. ACTION: Final rule. SUMMARY: The Commission has before it a Notice of Proposed Rulemaking...

  12. Motion-dependent representation of space in area MT+

    PubMed Central

    Fischer, Jason; Whitney, David

    2013-01-01

    Summary How is visual space represented in cortical area MT+? At a relatively coarse scale, the organization of MT+ is debated: Retinotopic, spatiotopic, or mixed representations have been proposed. However, none of these entirely explains perceptual localization of objects at a fine spatial scale—a scale relevant for tasks like navigating or manipulating objects. For example, perceived positions of objects are strongly modulated by visual motion: stationary flashes appear shifted in the direction of nearby motion. Does spatial coding in MT+ reflect these shifts in perceived position? We performed an fMRI experiment employing this “flash-drag effect”, and found that flashes presented near motion produced patterns of activity similar to physically shifted flashes in the absence of motion. This reveals a motion-dependent change in the neural representation of object position in human MT+, a process that could help compensate for perceptual and motor delays in localizing objects in dynamic scenes. PMID:23664618

  13. [Epidemiology of sexually transmitted infections in France].

    PubMed

    Herida, M; Michel, A; Goulet, V; Janier, M; Sednaoui, P; Dupin, N; de Barbeyrac, B; Semaille, C

    2005-05-01

    Sexually transmitted infections (STI) in France are reported on a voluntary basis through several sentinel surveillance systems. To monitor STI, sentinel laboratory- or clinician-based surveillance systems were set up by the Institut de Veille Sanitaire: gonorrhea surveillance (Renago) in 1986, Chlamydia infections surveillance (Renachla) in 1989, and more recently, syphilis surveillance in 2000 and rectal lymphogranuloma venereum (LGV) in 2004. From 2000 to 2003, 1,089 syphilis infections were reported. Most of the cases were diagnosed in men having sex with men (MSM) and were mainly reported by STI clinics located in the Paris area. From 1997 to 2000, an increase of gonorrhea was observed each year. After two years of stable trend, the prevalence of gonorrhea increased again in 2003. From 2002 to 2004, 123 LGV cases were diagnosed in France and were observed only in MSM. Since 2001, Chlamydia infections have steadily increased, particularly in women. Because STI surveillance is based on a voluntary basis, the number of reported cases is probably lower than the number of STI diagnosed in France. However, the data provided by the different surveillance systems reveals that STI have been increasing in France since 1997. Moreover, the resurgence of syphilis in 2000 and the emergence of rectal LGV in 2004 indicate that these STI occur mainly in MSM. Trends on incidence and patients characteristics observed in France are similar to those of several Europeans countries. European Public Health interventions are becoming necessary to prevent and control STI.

  14. [Epidemiology of tuberculosis in France in 2008].

    PubMed

    Che, D; Antoine, D

    2011-07-01

    A total of 5,758 tuberculosis cases were notified in France in 2008, giving a rate of nine cases per 100,000 inhabitants. The median age was 45 years and 59% of cases were male patients. Île-de-France (Paris and greater Paris area) and French Guiana had the highest notification rate in 2008 (17.9/10(5) and 22.6/10(5) respectively). The rate of tuberculosis was higher in individuals born abroad (43.2/10(5) vs. 5.0/10(5) for individuals born in France), especially those recently arrived in France. Pulmonary tuberculosis accounted for 72% of notified cases, 76% of which were potentially contagious (positive sputum smear, or culture). Compared to 2007, the number of notified tuberculosis cases increased by 3.3% in 2008. This increase was not accompanied by a rise of severe cases (meningitis and miliary TB); this seemed to be due partly to improvement in identification and notification of cases. However this trend could require specific monitoring in future years. A national tuberculosis control program was launched in France in 2007, aiming at reducing epidemiological disparities. Clinical and public health expertise needs to be maintained on all the territory to ensure that implemented measures can have the expected impact on the epidemiology of the disease.

  15. Atmospheric pollution for trace elements in the remote high-altitude atmosphere in central Asia as recorded in snow from Mt. Qomolangma (Everest) of the Himalayas.

    PubMed

    Lee, Khanghyun; Hur, Soon Do; Hou, Shugui; Hong, Sungmin; Qin, Xiang; Ren, Jiawen; Liu, Yapping; Rosman, Kevin J R; Barbante, Carlo; Boutron, Claude F

    2008-10-01

    A series of 42 snow samples covering over a one-year period from the fall of 2004 to the summer of 2005 were collected from a 2.1-m snow pit at a high-altitude site on the northeastern slope of Mt. Everest. These samples were analyzed for Al, V, Cr, Mn, Co, Ni, Cu, Zn, As, Rb, Sr, Cd, Sb, Pb, and Bi in order to characterize the relative contributions from anthropogenic and natural sources to the fallout of these elements in central Himalayas. Our data were also considered in the context of monsoon versus non-monsoon seasons. The mean concentrations of the majority of the elements were determined to be at the pg g(-1) level with a strong variation in concentration with snow depth. While the mean concentrations of most of the elements were significantly higher during the non-monsoon season than during the monsoon season, considerable variability in the trace element inputs to the snow was observed during both periods. Cu, Zn, As, Cd, Sb, and Bi displayed high crustal enrichment factors (EFc) in most samples, while Cr, Ni, Rb, and Pb show high EFc values in some of the samples. Our data indicate that anthropogenic inputs are potentially important for these elements in the remote high-altitude atmosphere in the central Himalayas. The relationship between the EFc of each element and the Al concentration indicates that a dominant input of anthropogenic trace elements occurs during both the monsoon and non-monsoon seasons, when crustal contribution is relatively minor. Finally, a comparison of the trace element fallout fluxes calculated in our samples with those recently obtained at Mont Blanc, Greenland, and Antarctica provides direct evidence for a geographical gradient of the atmospheric pollution with trace elements on a global scale.

  16. Revealing the hidden complexities of mtDNA inheritance.

    PubMed

    White, Daniel James; Wolff, Jonci Nikolai; Pierson, Melanie; Gemmell, Neil John

    2008-12-01

    Mitochondrial DNA (mtDNA) is a pivotal tool in molecular ecology, evolutionary and population genetics. The power of mtDNA analyses derives from a relatively high mutation rate and the apparent simplicity of mitochondrial inheritance (maternal, without recombination), which has simplified modelling population history compared to the analysis of nuclear DNA. However, in biology things are seldom simple, and advances in DNA sequencing and polymorphism detection technology have documented a growing list of exceptions to the central tenets of mitochondrial inheritance, with paternal leakage, heteroplasmy and recombination now all documented in multiple systems. The presence of paternal leakage, recombination and heteroplasmy can have substantial impact on analyses based on mtDNA, affecting phylogenetic and population genetic analyses, estimates of the coalescent and the myriad of other parameters that are dependent on such estimates. Here, we review our understanding of mtDNA inheritance, discuss how recent findings mean that established ideas may need to be re-evaluated, and we assess the implications of these new-found complications for molecular ecologists who have relied for decades on the assumption of a simpler mode of inheritance. We show how it is possible to account for recombination and heteroplasmy in evolutionary and population analyses, but that accurate estimates of the frequencies of biparental inheritance and recombination are needed. We also suggest how nonclonal inheritance of mtDNA could be exploited, to increase the ways in which mtDNA can be used in analyses.

  17. MT1-MMP: universal or particular player in angiogenesis?

    PubMed

    Genís, Laura; Gálvez, Beatriz G; Gonzalo, Pilar; Arroyo, Alicia G

    2006-03-01

    Tumorigenesis involves not only tumor cells that become transformed but also the peritumoral stroma which reacts inducing inflammatory and angiogenic responses. Angiogenesis, the formation of new capillaries from preexisting vessels, is an absolute requirement for tumor growth and metastasis, and it can be induced and modulated by a wide variety of soluble factors. During angiogenesis, quiescent endothelial cells are activated and they initiate migration by degrading the basement membranes through the action of specific proteases, in particular of matrix metalloproteinases (MMPs). Among these, the membrane type 1-matrix metalloproteinase (MT1-MMP) has been identified as a key player during the angiogenic response. In this review, we will summarize the role of MT1-MMP in angiogenesis and the regulatory mechanisms of this protease in endothelial cells. Since our recent findings have suggested that MT1-MMP is not universally required for angiogenesis, we hypothesize that the regulation and participation of MT1-MMP in angiogenesis may depend on the nature of the angiogenic stimulus. Experiments aimed at testing this hypothesis have shown that similarly to the chemokine stromal cell-derived factor-1 (SDF-1)/CXCL12, lipopolysaccharide (LPS) seems to induce the formation of capillary tubes by human or mouse endothelial cells (ECs) in an MT1-MMP-independent manner. The implications of these findings in the potential use of MT1-MMP inhibitors in cancer therapy are discussed.

  18. mtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia.

    PubMed

    Li, Hong; Bi, Rui; Fan, Yu; Wu, Yong; Tang, Yanqing; Li, Zongchang; He, Ying; Zhou, Jun; Tang, Jinsong; Chen, Xiaogang; Yao, Yong-Gang

    2017-08-01

    Although monozygotic (MZ) twins have theoretically identical nuclear DNA sequences, there may be phenotypic differences between them caused by somatic mutations and epigenetic changes affecting each genome. In this study, we collected eight families of MZ twins discordant for schizophrenia with the aim of investigating the potential role of mitochondrial DNA (mtDNA) heteroplasmy in causing the phenotypic differences between the twin pairs. Next-generation sequencing (NGS) technology was used to screen the whole mitochondrial genome of the twin pairs and their parents. The mtDNA heteroplasmy level was found to be nearly identical between the twin pairs but was distinctly different between each mother and their offspring. These results suggest that the discordance of schizophrenia between MZ twins may not be attributable to the difference in mtDNA heteroplasmy, and the high concordance of mtDNA heteroplasmy between MZ twins may indicate the relatively equal distribution of mtDNA during embryo separation of MZ twins and/or the modulation effect from the same nuclear genetic background. Furthermore, we observed an overrepresentation of heteroplasmy in noncoding regions and an elevated ratio of nonsynonymous heteroplasmy, suggesting the possible effects of a purifying selection in shaping the pattern of mtDNA heteroplasmy.

  19. Modelling rock wall permafrost degradation in the Mont Blanc massif from the LIA to the end of the 21st century

    NASA Astrophysics Data System (ADS)

    Magnin, Florence; Josnin, Jean-Yves; Ravanel, Ludovic; Pergaud, Julien; Pohl, Benjamin; Deline, Philip

    2017-08-01

    High alpine rock wall permafrost is extremely sensitive to climate change. Its degradation has a strong impact on landscape evolution and can trigger rockfalls constituting an increasing threat to socio-economical activities of highly frequented areas; quantitative understanding of permafrost evolution is crucial for such communities. This study investigates the long-term evolution of permafrost in three vertical cross sections of rock wall sites between 3160 and 4300 m above sea level in the Mont Blanc massif, from the Little Ice Age (LIA) steady-state conditions to 2100. Simulations are forced with air temperature time series, including two contrasted air temperature scenarios for the 21st century representing possible lower and upper boundaries of future climate change according to the most recent models and climate change scenarios. The 2-D finite element model accounts for heat conduction and latent heat transfers, and the outputs for the current period (2010-2015) are evaluated against borehole temperature measurements and an electrical resistivity transect: permafrost conditions are remarkably well represented. Over the past two decades, permafrost has disappeared on faces with a southerly aspect up to 3300 m a.s.l. and possibly higher. Warm permafrost (i.e. > - 2 °C) has extended up to 3300 and 3850 m a.s.l. in N and S-exposed faces respectively. During the 21st century, warm permafrost is likely to extend at least up to 4300 m a.s.l. on S-exposed rock walls and up to 3850 m a.s.l. depth on the N-exposed faces. In the most pessimistic case, permafrost will disappear on the S-exposed rock walls at a depth of up to 4300 m a.s.l., whereas warm permafrost will extend at a depth of the N faces up to 3850 m a.s.l., but possibly disappearing at such elevation under the influence of a close S face. The results are site specific and extrapolation to other sites is limited by the imbrication of local topographical and transient effects.

  20. Snow control on active layer and permafrost in steep alpine rock walls (Aiguille du Midi, 3842 m a.s.l, Mont Blanc massif)

    NASA Astrophysics Data System (ADS)

    Magnin, Florence; Westermann, Sebastian; Pogliotti, Paolo; Ravanel, Ludovic; Deline, Philip

    2016-04-01

    Permafrost degradation through the thickening of the active layer and the rising temperature at depth is a crucial process of rock wall stability. The ongoing increase in rock falls observed during hot periods in mid-latitude mountain ranges is regarded as a result of permafrost degradation. However, the short-term thermal dynamics of alpine rock walls are misunderstood since they result of complex processes related to the interaction of local climate variables, heterogeneous snow cover and heat transfers. As a consequence steady-state and long-term changes that can be approached with simpler process mainly related to air temperature, solar radiations and heat conduction were the most common dynamics to be studied so far. The effect of snow on the bedrock surface temperature is increasingly investigated and has already been demonstrated to be an essential factor of permafrost distribution. Nevertheless, its effect on the year-to-year changes of the active layer thickness and of the permafrost temperature in steep alpine bedrock has not been investigated yet, partly due to the lack of appropriate data. We explore the role of snow accumulations on the active layer and permafrost thermal regime of steep rock walls of a high-elevated site, the Aiguille du Midi (AdM, 3842 m a.s.l, Mont Blanc massif, Western European Alps) by mean of a multi-methods approach. We first analyse six years of temperature records in three 10-m-deep boreholes. Then we describe the snow accumulation patterns on two rock faces by means of automatically processed camera records. Finally, sensitivity analyses of the active layer thickness and permafrost temperature towards timing and magnitude of snow accumulations are performed using the numerical permafrost model CryoGrid 3. The energy balance module is forced with local meteorological measurements on the AdM S face and validated with surface temperature measurements at the weather station location. The heat conduction scheme is calibrated with

  1. A 4-year sediment trap record of alkenones from the filamentous upwelling region off Cape Blanc, NW Africa and a comparison with distributions in underlying sediments

    NASA Astrophysics Data System (ADS)

    Müller, Peter J.; Fischer, Gerhard

    2001-08-01

    We analysed long-chain alkenones in sinking particles and surface sediments from the filamentous upwelling region off Cape Blanc, NW Africa, to evaluate the transfer of surface water signals into the geological record. Our study is based on time-series sediment trap records from 730 m (1990-1991) to 2195-3562 m depth (1988-1991). Alkenone fluxes showed considerable interannual variations and no consistent seasonality. The average flux of C 37 and C 38 alkenones to the deep traps was 1.9 μg m -2 d -1 from March 1988 to October 1990 and sevenfold higher in the subsequent year. Alkenone fluxes to the shallower traps were on average twice as high and showed similar temporal variations. The alkenone unsaturation indices UK' 37, UK38Me and UK38Et closely mirrored the seasonal variations in sea-surface temperature (weekly Reynolds SST). Time lags of 10-48 days between the SST and unsaturation maxima suggest particle sinking rates of about 80 and 280 m d -1 for the periods of low and high alkenone fluxes, respectively. The average flux-weighted UK' 37 temperature for the 4-year time series of the deeper traps was 22.1°C, in perfect agreement with the mean weekly SST for the same period. This and the comparison with seasonal temperature variations in the upper 100 m of the water column suggests that UK' 37 records principally the yearly average of the mixed-layer temperature in this region. A comparison between the average annual alkenone fluxes to the lower traps (2400 μg m -2 yr -1) and into the underlying sediments (4 μg m -2 yr -1) suggests that only about 0.2% of the alkenones reaching the deep ocean became preserved in the sediments. The flux-weighted alkenone concentrations also decreased considerably, from 2466 μg gC -1 in the water column to 62 μg gC -1 in the surface sediments. Such a low degree of alkenone preservation is typical for slowly accumulating oxygenated sediments. Despite these dramatic diagenetic alkenone losses, the UK' 37 ratio was not

  2. Two-stage fluid flow and element transfers in shear zones during collision burial-exhumation cycle: Insights from the Mont Blanc Crystalline Massif (Western Alps)

    NASA Astrophysics Data System (ADS)

    Rolland, Y.; Rossi, M.

    2016-11-01

    The Mont-Blanc Massif was intensely deformed during the Alpine orogenesis: in a first stage of prograde underthrusting at c. 30 Ma and in a second stage of uplift and exhumation at 22-11 Ma. Mid-crustal shear zones of 1 mm-50 m size, neighbouring episyenites (quartz-dissolved altered granite) and alpine veins, have localised intense fluid flow, which produced substantial changes in mineralogy and whole-rock geochemistry. Four main metamorphic zones are oriented parallel to the strike of the massif: (i) epidote, (ii) chlorite, (iii) actinolite-muscovite ± biotite and (iv) muscovite ± biotite. In addition, phlogopite-bearing shear zones occur in the chlorite zone, and calcite-bearing shear zones are locally found in the muscovite zone. The initial chemical composition of the granitic protolith is relatively constant at massif scale, which allows investigating compositional changes related to shear zone activity, and subsequent volume change and elements mobility. The variations of whole-rock composition and mineral chemistry in shear zones reflect variations in fluid/rock ratios and fluid's chemistry, which have produced specific mineral reactions. Estimated time-integrated fluid fluxes are of the order of 106 m3/m2. The mineral assemblages that crystallised upon these fluid-P-T conditions are responsible for specific major and trace element enrichments. The XFe (Fe/Fe + Mg) pattern of shear zone phyllosilicates and the δ13C pattern of vein calcite both show a bell-type pattern across the massif with high values on the massif rims and low values in the centre of the massif. These low XFe and δ13C values are explained by down temperature up-flow of a Fe-Mg-CO2-rich and silica-depleted fluid during stage 1, while the massif was underthrusting. These produced phlogopite, chlorite and actinolite precipitation and quartz hydrolysis, resulting in strong volume losses. In contrast, during stage 2 (uplift), substantial volume gains occurred on the massif rims due to the

  3. Calendar-dated glacier variations in the western European Alps during the Neoglacial: the Mer de Glace record, Mont Blanc massif

    NASA Astrophysics Data System (ADS)

    Le Roy, Melaine; Nicolussi, Kurt; Deline, Philip; Astrade, Laurent; Edouard, Jean-Louis; Miramont, Cécile; Arnaud, Fabien

    2015-01-01

    Holocene glacier records from the western European Alps are still sparse, although a number of sites are well suited to constraining pre- and early- Little Ice Age (LIA) glacier advances. The present study provides the first dendrochronologically-based and calendar-dated Neoglacial glacier chronology for the Mont Blanc massif, French Alps. It is based on the analysis of over 240 glacially buried Pinus cembra subfossil logs and wood remains found either embedded-in-till or as detrital material in the Mer de Glace right lateral moraine. Only a few of the samples were found to be 'formally in situ' but we show that some logs were 'virtually in situ' (not rooted but showing little or no evidence of reworking) and could be used to accurately reconstruct past glacier margin behavior in space and time. Uncertainties regarding the other samples may relate to original growth location and/or to outer wood decay. The resulting dates (followed by a '+') were therefore considered maximum-limiting ages for glacier advances. The main burial events - interpreted as glacier advances - occurred between ca 1655+ and 1544+ BC, between ca 1230+ and 1105+ BC, between ca 1013+ and 962+/937+ BC, at ca 802-777 BC, after 608+ BC, between 312 and 337 AD, between ca 485+ AD and 606+ AD, between 1120 and 1178 AD, between ca 1248 and 1278+/1296 AD, and after 1352+ AD. These advances predate the late LIA maxima known from historical sources. The magnitude of the advances gradually increased to culminate in three near-Neoglacial maxima during the 7th, 12th and 13th centuries AD, followed by a first LIA/Neoglacial maximum in the second half of the 14th century AD. The pattern of Neoglacial events described here is coherent with Central and Eastern Alpine glacier chronologies. This indicates marked synchronicity of late Holocene glacier variability and forcing at a regional scale, although occasional differences could be detected between 'Western' and 'Eastern' records. The Mer de Glace record also

  4. [Utilization of methylphenidate(Ritalin) in France].

    PubMed

    Frances, C; Hoizey, G; Millart, H; Trenque, T

    2002-01-01

    Methylphenidate (Ritalin) is the only psychostimulant approved in France and indicated in attention deficit hyperactivity disorder in children over 6 years. It is under restricted prescription and distribution conditions. As such, it requires a hospital initiated prescription from either a neurology, psychiatry or pediatric specialist and it is covered by the "narcotics" schedule. The French Pharmacovigilance database spontaneous adverse drug reactions reporting, since it was approved in 1995, were analyzed. 21 adverse drug reactions were reported. In 16 cases, methylphenidate was suspected. They were generally non-serious, mild side effects and in most cases promptly resolved. These results do not suggest methylphenidate misuse in France or an overuse in between 1300 and 4000 treated children, to date. Until more information is available concerning the long-term effects of methylphenidate, and in order to limit misuse, inappropriate or overuse, the current prescription and dispensing regulation should be maintained in France, and could well be developed in other countries.

  5. [A case of donovanosis acquired in France].

    PubMed

    Okhremchuk, I; Marmottant, E; Abed, S; Nguyen, A-T; Fournier, B; Boye, T; Morand, J-J

    2016-11-01

    Donovanosis (granuloma inguinale) is a bacterial infection caused by Klebsiella granulomatis that occurs mainly in the genital area and is primarily sexually transmitted; it is seen predominantly in the tropics. Herein, we report a case of the disease contracted in metropolitan France. A 47-year-old man presented with painless ulceration of the glans, present for one month, with progressive extension; there was no history of any recent trip abroad. Skin biopsy with Whartin-Starry and Giemsa staining revealed Donovan bodies in the cytoplasm of macrophages. Based on these findings, further questioning of the patient revealed unprotected sexual contact two months earlier in France. Treatment was initiated with azithromycin 1g on the first day followed by 500mg per day for three weeks. The clinical outcome was spectacular, with almost complete regression of the ulcer at 7 days. This case demonstrates that donovanosis can occur in metropolitan France. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  6. Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-h vigilance states.

    PubMed

    Ochoa-Sanchez, Rafael; Comai, Stefano; Spadoni, Gilberto; Bedini, Annalida; Tarzia, Giorgio; Gobbi, Gabriella

    2014-02-21

    Melatonin (MLT) is a neurohormone implicated in several physiological processes such as sleep. Contrasting results have been produced on whether or not it may act as a hypnotic agent, and the neurobiological mechanism through which it controls the vigilance states has not yet been elucidated. In this study we investigated the effect of MLT (40 mg/kg), a non-selective MT1/MT2 receptor agonist (UCM793, 40 mg/kg), and a selective MT2 partial agonist (UCM924, 40 mg/kg) on the 24-h vigilance states. EEG and EMG sleep-wake patterns were registered across the 24-h light-dark cycle in adult Sprague-Dawley male rats. MLT decreased (-37%) the latency to the first episode of non rapid eye movement sleep (NREMS), enhanced the power of NREMS delta band (+33%), but did not alter the duration of any of the three vigilance states. Differently, UCM793 increased the number of episodes (+52%) and decreased the length of the episodes (-38%) of wakefulness but did not alter the 24-h duration of wakefulness, NREMS and REMS. UCM924 instead reduced the latency (-56%) and increased (+31%) the duration of NREMS. Moreover, it raised the number of REMS episodes (+57%) but did not affect REMS duration. Taken together, these findings show that MLT and non-selective MT1/MT2 receptor agonists do not increase the quantity of sleep but differently influence the three vigilance states. In addition, they support the evidence that selective MT2 receptor agonists increase NREMS duration compared to MLT and non-selective MT1/MT2 agonists.

  7. Single domain metallothioneins: supermetalation of human MT 1a.

    PubMed

    Sutherland, Duncan E K; Willans, Mathew J; Stillman, Martin J

    2012-02-15

    Metallothioneins are a family of small, cysteine rich proteins that have been implicated in a range of roles including toxic metal detoxification, protection against oxidative stress, and as metallochaperones involved in the homeostasis of both essential zinc and copper. We report that human metallothionein 1a, well-known to coordinate 7 Zn(2+) or Cd(2+) ions with 20 cysteinyl thiols, will bind 8 structurally significant Cd(2+) ions, leading to the formation of the supermetalated Cd(8)-βα-rhMT 1a species, for which the structure is a novel single domain. ESI-mass spectrometry was used to determine the exact metalation status of the βα-rhMT. The derivative-shaped CD envelope of Cd(7)-βα-rhMT [peak extrema (+) 260 and (-) 239 nm] changed drastically upon formation of the Cd(8)-βα-rhMT with the appearance of a sharp monophasic CD band centered on 252 nm, a feature indicative of the loss of cluster symmetry. The structural significance of the eighth Cd(2+) ion was determined from a combination of direct and indirect (113)Cd nuclear magnetic resonance (NMR) spectra. In the case of Cd(8)-βα-rhMT, only four peaks were observed in the direct (113)Cd NMR spectrum. Significantly, while both of the isolated domains can be supermetalated forming Cd(4)-β-rhMT and Cd(5)-α-rhMT, Cd(8)-βα-rhMT and not Cd(9)-βα-rhMT was observed following addition of excess Cd(2+). We propose that both domains act in concert to coordinate the eighth Cd(2+) atom, and furthermore that this interaction results in a coalescence of the two domains leading to collapse of the two-domain structure. This is the first report of a possible single-"superdomain" metallothionein structure for Zn(2+) and Cd(2+) binding mammalian proteins. A computational model of a possible single-domain structure of Cd(8)-βα-rhMT is described.

  8. [Foreign-born youth in France].

    PubMed

    Tribalat, M

    1996-12-01

    Data from an INED survey on migration and social integration (Mobilite Geographique et Insertion Sociale) carried out in France in 1992 are used to examine the process of assimilation of young people aged 20-29 in France. The results show that although there are many problems facing the young of foreign origin, and particularly those of North African origin, the situation concerning their integration into French society has improved significantly over the course of a generation despite the economic and social problems affecting the country that have made the process of assimilation more difficult.

  9. Kinetic evidence for different mechanisms of interaction of black mamba toxins MT alpha and MT beta with muscarinic receptors.

    PubMed

    Jolkkonen, M; Oras, A; Toomela, T; Karlsson, E; Järv, J; Akerman, K E

    2001-01-01

    By studying the influence of two toxins from the black mamba Dendroaspis polylepis on the kinetics of [3H]-N-methylscopolamine binding to muscarinic acetylcholine receptors from rat cerebral cortex, it was revealed that these toxins, MT alpha and MT beta, interact with the receptors via kinetically distinct mechanisms. MT beta bound to receptors in a one-step, readily reversible process with the dissociation constant K(d)=5.3 microM. The binding mechanism of MTalpha was more complex, involving at least two consecutive steps. A fast receptor-toxin complex formation (K(T)=3.8 microM) was followed by a slow process of isomerisation of this complex (k(i)=1.8 x 10(-2) s(-1), half-time 39 s). A similar two-step interaction mechanism has been established for a related toxin, MT2 from the green mamba D. angusticeps (K(T)=1.4 microM, k(i)=8.3 x 10(-4) s(-1), half-time 840 s). The slow isomerisation process delays the effect of MT alpha and MT2, but increases their apparent potency compared to toxins unable to induce the isomerisation process.

  10. Directed Replacement of Mt a by Mt a-1 Effects a Mating Type Switch in Neurospora Crassa

    PubMed Central

    Chang, S.; Staben, C.

    1994-01-01

    To test the functions of a mating type genes, we developed an efficient strategy to select transformants of Neurospora crassa in which resident A mating type DNA was replaced by cloned DNA from the mt a idiomorph. Cloned a idiomorphic DNA could specify all functions, including fertility, of a mating type, but only when it replaced A DNA at the mating type locus. Only the mt a-1 region of the a idiomorph was necessary in order to specify a mating type. Gene replacement events involved the homologous sequences flanking the unique mating type idiomorphic DNA, resulting in apparently isogenic a and A strains. These isogenic strains were fertile when crossed with one another, indicating that no determinants outside the transforming DNA are necessary for fertility as a and that no host sequences of A strains interfere with fertility as a. One a replacement strain bore a duplication of the transforming mt a-1 and hph DNA. The duplication strain had unexpected properties. Although mating type segregated 1:1 in crosses of this strain to A, the duplicated regions were efficiently altered during the sexual process to generate a single copy in the progeny. No progeny were recovered that had undergone RIP (repeat induced point mutation) sufficient to inactivate the mt a-1 gene. We infer that the mt a-1 gene is necessary and sufficient to specify a mating type identity in all vegetative and sexual activities. Mt a-1 may also play an essential role in ascosporogenesis after fertilization. PMID:8001795

  11. Body composition and hematological changes following ascents of Mt. Aconcagua and Mt. Everest.

    PubMed

    Wagner, Dale R

    2010-11-01

    Both Mt. Aconcagua (22,841.2 ft/6962 m) and Mt. Everest (29,035.4 ft/ 8850 m) are highly prized summits by mountaineers, yet there are no published studies comparing the physiological adaptations that occur from climbing both peaks. This case study compares the changes in body composition and hematology of a mountaineer who ascended both peaks. The male subject was 41 yr of age during the Aconcagua ascent and 43 yr of age during the Everest ascent, and had a history of ascents above 19,685 ft (6000 m). Baseline body composition measurements and blood draws were done within a few days of departure for both expeditions. Body composition was assessed by air displacement plethysmography and the blood draw consisted of a complete blood count (CBC). Post-expedition measurements were taken 10-14 d after reaching the summits. The ascent of Aconcagua resulted in a 2.0-kg drop in body mass and a reduction in body fat (15.5% to 12.1%), but blood chemistry remained within +/- 2% of baseline values. Body mass was reduced from 65.0 kg to 60.5 kg during the Everest expedition with a drop in body fat from 17.3% to 10.2%. Despite no change in RBCs there were increases in hemoglobin and mean corpuscular hemoglobin of 12.7% and 13.7%, respectively. It took the subject 12 d to reach the summit of Aconcagua, whereas it took 50 d to reach the summit of Everest. The longer duration at higher altitude for the Everest expedition resulted in more dramatic physiological changes.

  12. Effects of the melatonin MT-1/MT-2 agonist ramelteon on daytime body temperature and sleep.

    PubMed

    Markwald, Rachel R; Lee-Chiong, Teofilo L; Burke, Tina M; Snider, Jesse A; Wright, Kenneth P

    2010-06-01

    A reduction in core temperature and an increase in the distal-proximal skin gradient (DPG) are reported to be associated with shorter sleep onset latencies (SOL) and better sleep quality. Ramelteon is a melatonin MT-1/MT-2 agonist approved for the treatment of insomnia. At night, ramelteon has been reported to shorten SOL. In the present study we tested the hypothesis that ramelteon would reduce core temperature, increase the DPG, as well as shorten SOL, reduce wakefulness after sleep onset (WASO), and increase total sleep time (TST) during a daytime sleep opportunity. Randomized, double-blind, placebo-controlled, cross-over design. Eight mg ramelteon or placebo was administered 2 h prior to a 4-h daytime sleep opportunity. Sleep and chronobiology laboratory. Fourteen healthy adults (5 females), aged (23.2 +/- 4.2 y). Primary outcome measures included core body temperature, the DPG and sleep physiology (minutes of total sleep time [TST], wake after sleep onset [WASO], and SOL). We also assessed as secondary outcomes, proximal and distal skin temperatures, sleep staging and subjective TST. Repeated measures ANOVA revealed ramelteon significantly reduced core temperature and increased the DPG (both P < 0.05). Furthermore, ramelteon reduced WASO and increased TST, and stages 1 and 2 sleep (all P < 0.05). The change in the DPG was negatively correlated with SOL in the ramelteon condition. Ramelteon improved daytime sleep, perhaps mechanistically in part by reducing core temperature and modulating skin temperature. These findings suggest that ramelteon may have promise for the treatment of insomnia associated with circadian misalignment due to circadian sleep disorders.

  13. The Formation and Erosion History of Mt. Sharp

    NASA Technical Reports Server (NTRS)

    Allen, Carlton C.; Dapremont, Angela M.

    2014-01-01

    The Curiosity rover is exploring 155 km diameter Gale crater and Mt. Sharp, Gale's 5 km high central mound (Fig. 1). This study addresses the formation and erosion history of Mt. Sharp. Gale lies on the topographic dichotomy between the southern highlands and the northern plains - a drop of over 2 km [1,2]. Altitude differences between the north and south rim reflect this regional slope, as do altitude differences between the deep annulus north of Mt. Sharp and the southern crater floor. Orbiter and rover images demonstrate that most exposed areas on Mt. Sharp consist of thin, sub-parallel units interpreted as sedimentary layers [3]. Gale is typical of the 50 large martian craters that have been totally or partially filled with such layers [4,5]. In many craters these sediments have been deeply eroded. Central Peak and Peak Ring: The highest point on Mt. Sharp, near the crater's center, is interpreted as a central peak [6]. The peak has a massive lower portion and a thin, smooth capping deposit (Fig. 2). Gale's size is transitional between martian craters with single central peaks and craters with peak rings approximately half the crater's diameter [2,6]. The boundaries of Mt. Sharp, as well as an arc of hills to the southeast of the mountain, closely match a circle approximately 80 km in diameter (Fig. 3). This morphology suggests that the Gale impact may have formed both a central peak and a partial peak ring, which is covered by the sediments of Mt. Sharp in the north and possibly exposed in the arc of eroded hills in the southeast quadrant (Figs. 3,4).

  14. 77 FR 20747 - Proposed Amendment of Class E Airspace; Billings, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-06

    ... action proposes to modify Class E airspace at Billings Logan International Airport, Billings, MT, to... feet or more above the surface of the earth. * * * * * ANM MT E5 Billings, MT Billings Logan... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Billings, MT AGENCY...

  15. Transcriptional quiescence of paternal mtDNA in cyprinid fish embryos

    PubMed Central

    Wen, Ming; Peng, Liangyue; Hu, Xinjiang; Zhao, Yuling; Liu, Shaojun; Hong, Yunhan

    2016-01-01

    Mitochondrial homoplasmy signifies the existence of identical copies of mitochondrial DNA (mtDNA) and is essential for normal development, as heteroplasmy causes abnormal development and diseases in human. Homoplasmy in many organisms is ensured by maternal mtDNA inheritance through either absence of paternal mtDNA delivery or early elimination of paternal mtDNA. However, whether paternal mtDNA is transcribed has remained unknown. Here we report that paternal mtDNA shows late elimination and transcriptional quiescence in cyprinid fishes. Paternal mtDNA was present in zygotes but absent in larvae and adult organs of goldfish and blunt-snout bream, demonstrating paternal mtDNA delivery and elimination for maternal mtDNA inheritance. Surprisingly, paternal mtDNA remained detectable up to the heartbeat stage, suggesting its late elimination leading to embryonic heteroplasmy up to advanced embryogenesis. Most importantly, we never detected the cytb RNA of paternal mtDNA at all stages when paternal mtDNA was easily detectable, which reveals that paternal mtDNA is transcriptionally quiescent and thus excludes its effect on the development of heteroplasmic embryos. Therefore, paternal mtDNA in cyprinids shows late elimination and transcriptional quiescence. Clearly, transcriptional quiescence of paternal mtDNA represents a new mechanism for maternal mtDNA inheritance and provides implications for treating mitochondrion-associated diseases by mitochondrial transfer or replacement. PMID:27334806

  16. Measurements of IN and BIO-IN with the fast ice nucleus chamber FINCH at Mt. Zugspitze, Mt. Puy de Dôme and Jungfraujoch during fall and winter

    NASA Astrophysics Data System (ADS)

    Nillius, B.; Frank, F.; Bingemer, H.; Curtius, J.; Bundke, U.

    2013-05-01

    In this work we present IN measurements at Mt. Zugspitze, Germany, 2650 m.a.s.l., Mt. Puy de Dôme, France, 1464 m.a.s.l. and Jungfraujoch, Switzerland, 3580 m a.s.l during fall and winter 2012 with the instrument FINCH HALO (Fast Ice Nucleus Chamber for the High Altitude and LOng range research aircraft HALO). In this device the temperature and super saturation for activation of Ice Nuclei (IN) and the growth to ice crystals is obtained by mixing three gas flows of different temperatures and moisture. After the growth of IN and Cloud Condensation Nuclei (CCN) to macroscopic ice crystals and super-cooled water droplets in the development chamber, they are counted using an optical detector. The discrimination between ice and water is made by measuring the circular depolarization ratio of the backscattered laser light of each individual particle. IN are classified as biological particles by measuring their individual intrinsic-fluorescence during the winter campaigns in average 30-40 % of the IN show an intrinsic fluorescence and are supposed to be of biological origin.

  17. 78 FR 49115 - Airworthiness Directives; Eurocopter France Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ...-100-AD; Amendment 39-17285; AD 2012-25-04] RIN 2120-AA64 Airworthiness Directives; Eurocopter France... applies to certain Eurocopter France (Eurocopter) Model AS350B3 helicopters. The reference to Title...

  18. A Model of Binocular Motion Integration in MT Neurons.

    PubMed

    Baker, Pamela M; Bair, Wyeth

    2016-06-15

    Primate cortical area MT plays a central role in visual motion perception, but models of this area have largely overlooked the binocular integration of motion signals. Recent electrophysiological studies tested binocular integration in MT and found surprisingly that MT neurons lose their hallmark "pattern motion" selectivity when stimuli are presented dichoptically and that many neurons are selective for motion-in-depth (MID). By unifying these novel observations with insights from monocular, frontoparallel motion studies concurrently in a binocular MT motion model, we generated clear, testable predictions about the circuitry and mechanisms underlying visual motion processing. We built binocular models in which signals from left- and right-eye streams could be integrated at various stages from V1 to MT, attempting to create the simplest plausible circuits that accounted for the physiological range of pattern motion selectivity, that explained changes across this range for dichoptic stimulus presentation, and that spanned the spectrum of MID selectivity observed in MT. Our successful models predict that motion-opponent suppression is the key mechanism to account for the striking loss of pattern motion sensitivity with dichoptic plaids, that opponent suppression precedes binocular integration, and that opponent suppression will be stronger in inputs to pattern cells than to component cells. We also found an unexpected connection between circuits for pattern motion selectivity and MID selectivity, suggesting that these two separately studied phenomena could be related. These results also hold in models that include binocular disparity computations, providing a platform for future exploration of binocular response properties in MT. The neural pathways underlying our sense of visual motion are among the most studied and well-understood parts of the primate cerebral cortex. Nevertheless, our understanding is incomplete because electrophysiological research has focused

  19. Frances Rauscher: Music and Reasoning. Interview.

    ERIC Educational Resources Information Center

    Snyder, Neal

    1995-01-01

    Reports on an interview with Frances Rauscher, a research psychologist and musician who has studied the effects of music on the brain. Maintains that students who have studied music have enhanced spatial reasoning. Recommends that music education begin at younger ages. (CFR)

  20. World Foods. The Flavor of France.

    ERIC Educational Resources Information Center

    Calhoun, Helen; And Others

    This teacher's guide contains materials to be used in a study of France and its cuisine. Unit 1 provides an overview of French geographic, political, economic, social, and cultural characteristics. Unit 2 studies French food habits, nutrition, food preparation, and meal patterns. Each unit contains a list of objectives (e.g., identify the type of…

  1. Haemovigilance and transfusion safety in France.

    PubMed

    Rouger, P; Noizat-Pirenne, F; Le Pennec, P Y

    2000-01-01

    The risks associated to red cell and platelet transfusions are essentially bound to the polymorphism of blood group antigens and to transfusion transmitted agents including virus, bacterias.... In France, the haemovigilance system and several investigations allowed to measure these different kinds of risks. We also developed analysis of failures in order to prevent errors and accidents to increase blood safety.

  2. Competence: Conceptual Approach and Practice in France

    ERIC Educational Resources Information Center

    Le Deist, Francoise

    2009-01-01

    Purpose: The purpose of this article is to analyse the conceptual approaches to competence and practice in competence management in France. Design/methodology/approach: Extensive literature review, discussion with academic experts in the French competence network of AGRH and interviews concerning developments following the 2003 national agreement…

  3. France's Rich Relation: The Oc Connection.

    ERIC Educational Resources Information Center

    Belasco, Simon

    1990-01-01

    A discussion of Occitan, a Romance language spoken in a large portion of France, looks at the history; irregular characteristics; orthographic and morphophonemic variations across dialects; and present status, which is in danger of becoming extinct because of neglect, of the language. (MSE)

  4. A Paradox in Physics Education in France

    ERIC Educational Resources Information Center

    Smigiel, Eddie; Sonntag, Michel

    2013-01-01

    This paper deals with the nature and the level of difficulty of teaching and learning physics in the first year of undergraduate engineering schools in France. Our case study is based on a survey regarding a classic and basic question in applied physics, and which was conducted with a group of second-year students in a post-baccalaureate 1…

  5. World Foods. The Flavor of France.

    ERIC Educational Resources Information Center

    Calhoun, Helen; And Others

    This teacher's guide contains materials to be used in a study of France and its cuisine. Unit 1 provides an overview of French geographic, political, economic, social, and cultural characteristics. Unit 2 studies French food habits, nutrition, food preparation, and meal patterns. Each unit contains a list of objectives (e.g., identify the type of…

  6. Murine Typhus, Reunion, France, 2011–2013

    PubMed Central

    Camuset, Guillaume; Socolovschi, Cristina; Moiton, Marie-Pierre; Kuli, Barbara; Foucher, Aurélie; Poubeau, Patrice; Borgherini, Gianandrea; Wartel, Guillaume; Audin, Héla; Raoult, Didier; Filleul, Laurent; Parola, Philippe; Pagès, Fréderic

    2015-01-01

    Murine typhus case was initially identified in Reunion, France, in 2012 in a tourist. Our investigation confirmed 8 autochthonous cases that occurred during January 2011–January 2013 in Reunion. Murine typhus should be considered in local patients and in travelers returning from Reunion who have fevers of unknown origin. PMID:25625653

  7. France: Nukes Stuck between NATO and EU

    DTIC Science & Technology

    2013-03-01

    On words alone, however, the French may seem more prone to use nuclear weapons, which may start a potential chain reaction that could lead to the...A COLD HANDSHAKE BETWEEN THE FRENCH AND THE UNITED STATES...height of the Cold War. In the 1950s, France embarked on a campaign of building for nuclear energy to power its postwar reconstruction and nuclear

  8. A Paradox in Physics Education in France

    ERIC Educational Resources Information Center

    Smigiel, Eddie; Sonntag, Michel

    2013-01-01

    This paper deals with the nature and the level of difficulty of teaching and learning physics in the first year of undergraduate engineering schools in France. Our case study is based on a survey regarding a classic and basic question in applied physics, and which was conducted with a group of second-year students in a post-baccalaureate 1…

  9. The emergence of cognitive science in France.

    PubMed

    Chamak, B

    1999-10-01

    A comparison between the development of cognitive science in France and the USA enables us to analyze some national differences linked to specific connections between the scientific, military, economic and political worlds. The influence of new practices and tools developed during World War II and the Cold War appears to be of crucial importance in understanding the development of this new field, as well as that of cybernetics, computer science, artificial intelligence and molecular biology. This paper can be considered as a study in how the differing contexts in France and the USA shaped the history of the construction of cognitive science in each of these two countries. In spite of various differences, some common aspects may be pointed out: in both cases, computer experts and psychologists using a computational modelling approach were those first engaged in the construction of cognitive science. If in France neuroscience-oriented cognitive science research was stronger than in the USA, it seems that the artificial intelligence orientation is also of growing importance in France.

  10. Competence: Conceptual Approach and Practice in France

    ERIC Educational Resources Information Center

    Le Deist, Francoise

    2009-01-01

    Purpose: The purpose of this article is to analyse the conceptual approaches to competence and practice in competence management in France. Design/methodology/approach: Extensive literature review, discussion with academic experts in the French competence network of AGRH and interviews concerning developments following the 2003 national agreement…

  11. Spatial precision of population activity in primate area MT

    PubMed Central

    Morley, John W.; Solomon, Samuel G.

    2015-01-01

    The middle temporal (MT) area is a cortical area integral to the “where” pathway of primate visual processing, signaling the movement and position of objects in the visual world. The receptive field of a single MT neuron is sensitive to the direction of object motion but is too large to signal precise spatial position. Here, we asked if the activity of MT neurons could be combined to support the high spatial precision required in the where pathway. With the use of multielectrode arrays, we recorded simultaneously neural activity at 24–65 sites in area MT of anesthetized marmoset monkeys. We found that although individual receptive fields span more than 5° of the visual field, the combined population response can support fine spatial discriminations (<0.2°). This is because receptive fields at neighboring sites overlapped substantially, and changes in spatial position are therefore projected onto neural activity in a large ensemble of neurons. This fine spatial discrimination is supported primarily by neurons with receptive fields flanking the target locations. Population performance is degraded (by 13–22%) when correlations in neural activity are ignored, further reflecting the contribution of population neural interactions. Our results show that population signals can provide high spatial precision despite large receptive fields, allowing area MT to represent both the motion and the position of objects in the visual world. PMID:26041825

  12. MtDNA haplogroups and elite Korean athlete status.

    PubMed

    Kim, K C; Cho, H I; Kim, W

    2012-01-01

    Mitochondrial DNA (mtDNA) variation has recently been suggested to have an association with athletic performance or physical endurance. Since mtDNA is haploid and lacks recombination, specific mutations in the mtDNA genome associated with human exercise tolerance or intolerance arise and remain in particular genetic backgrounds referred to as haplogroups. To assess the possible contribution of mtDNA haplogroup-specific variants to differences in elite athletic performance, we performed a population-based study of 152 Korean elite athletes [77 sprint/power athletes (SPA) and 75 endurance/middle-power athletes (EMA)] and 265 non-athletic controls (CON). The overall haplogroup distribution of EMA differed significantly from CON (p<0.01), but that of SPA did not. The EMA have an excess of haplogroups M* (OR 4.38, 95% CI 1.63-11.79, p=0.003) and N9 (OR 2.32, 95% CI 0.92-5.81, p=0.042), but a dearth of haplogroup B (OR 0.26, 95% CI 0.09-0.75, p=0.003) compared with the CON. Thus, our data imply that specific mtDNA lineages may provide a significant effect on elite Korean endurance status, although functional studies with larger sample sizes are necessary to further substantiate these findings.

  13. The mitochondrial Italian Human Proteome Project initiative (mt-HPP).

    PubMed

    Urbani, Andrea; De Canio, Michele; Palmieri, Ferdinando; Sechi, Salvatore; Bini, Luca; Castagnola, Massimo; Fasano, Mauro; Modesti, Alessandra; Roncada, Paola; Timperio, Anna Maria; Bonizzi, Luigi; Brunori, Maurizio; Cutruzzolà, Francesca; De Pinto, Vito; Di Ilio, Carmine; Federici, Giorgio; Folli, Franco; Foti, Salvatore; Gelfi, Cecilia; Lauro, Davide; Lucacchini, Antonio; Magni, Fulvio; Messana, Irene; Pandolfi, Pier Paolo; Papa, Sergio; Pucci, Piero; Sacchetta, Paolo

    2013-08-01

    Mitochondria carry maternally inherited genetic material, called the mitochondrial genome (mtDNA), which can be defined as the 25th human chromosome. The chromosome-centric Human Proteome Project (c-HPP) has initially focused its activities addressing the characterization and quantification of the nuclear encoded proteins. Following the last International HUPO Congress in Boston (September 2012) it was clear that however small the mitochondrial chromosome is, it plays an important role in many biological and physiopathological functions. Mutations in the mtDNA have been shown to be associated with dozens of unexplained disorders and the information contained in the mtDNA should be of major relevance to the understanding of many human diseases. Within this paper we describe the Italian initiative of the Human Proteome Project dedicated to mitochondria as part of both programs: chromosome-centric (c-HPP) and Biology/Disease (B/D-HPP). The mt-HPP has finally shifted the attention of the HUPO community outside the nuclear chromosomes with the general purpose to highlight the mitochondrial processes influencing the human health. Following this vision and considering the large interest and evidence collected on the non-Mendelian heredity of Homo sapiens associated with mt-chromosome and with the microbial commensal ecosystem constituting our organism we may speculate that this program will represent an initial step toward other HPP initiatives focusing on human phenotypic heredity.

  14. Les instituts universitaires de technologie en France. (The university institutes of technology in France)

    ERIC Educational Resources Information Center

    Pineau, Gaston

    1971-01-01

    In 1966 France passed legislation naming three types of technical training: two year postbaccalaureate, short-cycle for those without a bachelor's degree, adult education, for those already employed. (MF)

  15. Melatonin receptors MT1 and MT2 are expressed in spermatozoa from several seasonal and nonseasonal breeder species.

    PubMed

    González-Arto, Marta; Vicente-Carrillo, Alejandro; Martínez-Pastor, Felipe; Fernández-Alegre, Estela; Roca, Jordi; Miró, Jordi; Rigau, Teresa; Rodríguez-Gil, Joan E; Pérez-Pé, Rosaura; Muiño-Blanco, Teresa; Cebrián-Pérez, José A; Casao, Adriana

    2016-11-01

    Melatonin is a ubiquitous and multipurpose molecule, and one of its roles is to regulate reproduction in some seasonal mammals. Our group has previously reported the variation in the melatonin levels in ram seminal plasma along the year and identified MT1 and MT2 receptors in ram spermatozoa. The objective of this study was to elucidate whether the presence of melatonin receptors (MT1 and MT2) in the sperm plasma membrane, and melatonin in the seminal plasma is related to seasonal breeding. For this purpose, the presence of melatonin receptors and the levels of melatonin in seminal plasma have been examined in several species: donkey and stallion as long-day breeders; red deer as a wild, short-day, highly seasonal breeder (epididymal spermatozoa); bull as a conventional nonseasonal breeder; boar as a seasonal breeder under management techniques; and dog as possible a seasonal breeder not regulated by melatonin. We have detected measurable levels of melatonin in the seminal plasma of all ejaculated semen samples (from donkey, stallion, boar, bull, and dog). Also, and for the first time, we have demonstrated the presence of MT1 and MT2 melatonin receptors in the spermatozoa of all these species, regardless their type of reproduction or sperm source (ejaculated or epididymal), using indirect immunofluorescence techniques and Western blotting. Our findings suggest that melatonin and melatonin receptors may be universally distributed in the reproductive system of mammals and that the sperm melatonin receptors cells may not be necessarily related with seasonal reproduction. Furthermore, the presence of MT1 at the cytoplasmic droplet in immature ejaculated stallion spermatozoa found in one sample and epididymal red deer spermatozoa suggests that melatonin may be involved in specific functions during spermatogenesis and sperm maturation, like protecting spermatozoa from oxidative damage, this activity being mediated through these receptors. Copyright © 2016 Elsevier Inc

  16. Caenorhabditis elegans metallothionein isoform specificity--metal binding abilities and the role of histidine in CeMT1 and CeMT2.

    PubMed

    Bofill, Roger; Orihuela, Rubén; Romagosa, Míriam; Domènech, Jordi; Atrian, Sílvia; Capdevila, Mercè

    2009-12-01

    Two metallothionein (MT) isoforms have been identified in the model nematode Caenorhabditis elegans: CeMT1 and CeMT2, comprising two polypeptides that are 75 and 63 residues in length, respectively. Both isoforms encompass a conserved cysteine pattern (19 in CeMT1 and 18 in CeMT2) and, most significantly, as a result of their coordinative potential, CeMT1 includes four histidines, whereas CeMT2 has only one. In the present study, we present a comprehensive and comparative analysis of the metal [Zn(II), Cd(II) and Cu(I)] binding abilities of CeMT1 and CeMT2, performed through spectroscopic and spectrometric characterization of the recombinant metal-MT complexes synthesized for wild-type isoforms (CeMT1 and CeMT2), their separate N- and C-terminal moieties (NtCeMT1, CtCeMT1, NtCeMT2 and CtCeMT2) and a DeltaHisCeMT2 mutant. The corresponding in vitro Zn/Cd- and Zn/Cu-replacement and acidification/renaturalization processes have also been studied, as well as protein modification strategies that make it possible to identify and quantify the contribution of the histidine residues to metal coordination. Overall, the data obtained in the present study are consistent with a scenario where both isoforms exhibit a clear preference for divalent metal ion binding, rather than for Cu coordination, although this preference is more pronounced towards cadmium for CeMT2, whereas it is markedly clearer towards Zn for CeMT1. The presence of histidines in these MTs is revealed to be decisive for their coordination performance. In CeMT1, they contribute to the binding of a seventh Zn(II) ion in relation to the M(II)(6)-CeMT2 complexes, both when synthesized in the presence of supplemented Zn(II) or Cd(II). In CeMT2, the unique C-terminal histidine abolishes the Cu-thionein character that this isoform would otherwise exhibit.

  17. Satellite remote sensing of hailstorms in France

    NASA Astrophysics Data System (ADS)

    Melcón, Pablo; Merino, Andrés; Sánchez, José Luis; López, Laura; Hermida, Lucía

    2016-12-01

    Hailstorms are meteorological phenomena of great interest to the scientific community, owing to their socioeconomic impact, which is mainly on agricultural production. With its global coverage and high spatial and temporal resolution, satellite remote sensing can contribute to monitoring of such events through the development of appropriate techniques. This paper presents an extensive validation in the south of France of a hail detection tool (HDT) developed for the Middle Ebro Valley (MEV). The HDT is based on consecutive application of two filters, a convection mask (CM) and hail mask (HM), using spectral channels of the Meteosat Second Generation (MSG) satellite. The south of France is an ideal area for studying hailstorms, because there is a robust database of hail falls recorded by an extensive network of hailpads managed by the Association Nationale d'Etude et de Lutte contre les Fleáux Atmosphériques (ANELFA). The results show noticeably poorer performance of the HDT in France relative to that in the MEV, with probability of detection (POD) 60.4% and false alarm rate (FAR) 26.6%. For this reason, a new tool to suit the characteristics of hailstorms in France has been developed. The France Hail Detection Tool (FHDT) was developed using logistic regression from channels of the Spinning Enhanced Visible and Infrared Imager (SEVIRI) sensor of the MSG. The FHDT was validated, resulting in POD 69.3% and FAR 15.4%, thus improving hail detection in the study area as compared with the previous tool. The new tool was tested in a case study with satisfactory results, supporting its future practical application.

  18. 77 FR 18965 - Airworthiness Directives; Eurocopter France Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... Directives; Eurocopter France Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... Eurocopter France Model SA341G helicopters. This proposed AD is prompted by an analysis and tests performed... Civile (DGAC), which is the aviation authority for France, has issued French AD No. F-2004-070, dated...

  19. 77 FR 70382 - Airworthiness Directives; Eurocopter France Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for Eurocopter France Model EC 155B... France EC 155, SA 366, SA 365, and AS 365 model helicopters, except those with certain modifications...) Applicability This AD applies to Eurocopter France Model EC 155B, EC155B1, and SA-366G1 helicopters,...

  20. Aging in France: Population Trends, Policy Issues, and Research Institutions

    ERIC Educational Resources Information Center

    Beland, Daniel; Durandal, Jean-Philippe Viriot

    2013-01-01

    Like in other advanced industrial countries, in France, demographic aging has become a widely debated research and policy topic. This article offers a brief overview of major aging-related trends in France. The article describes France's demographics of aging, explores key policy matters, maps the institutional field of French social gerontology…

  1. 77 FR 43734 - Airworthiness Directives; Eurocopter France Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; Eurocopter France...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for Eurocopter France (Eurocopter) Model... Determination This helicopter model is manufactured in France and is type certificated for operation in the...

  2. 78 FR 75579 - Low Enriched Uranium From France

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... COMMISSION Low Enriched Uranium From France Determination On the basis of the record \\1\\ developed in the... antidumping duty order on low enriched uranium from France would be likely to lead to continuation or...), entitled Low Enriched Uranium from France: Investigation No. 731-TA-909 (Second Review). By order of the...

  3. 78 FR 857 - Airworthiness Directives; Eurocopter France Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-07

    ...-17302; AD 2012-26-07] RIN 2120-AA64 Airworthiness Directives; Eurocopter France Helicopters AGENCY... airworthiness directive (AD) for Eurocopter France (Eurocopter) Model AS350BA helicopters with certain AERAZUR... Determination These helicopters have been approved by the aviation authority of France and are approved for...

  4. Aging in France: Population Trends, Policy Issues, and Research Institutions

    ERIC Educational Resources Information Center

    Beland, Daniel; Durandal, Jean-Philippe Viriot

    2013-01-01

    Like in other advanced industrial countries, in France, demographic aging has become a widely debated research and policy topic. This article offers a brief overview of major aging-related trends in France. The article describes France's demographics of aging, explores key policy matters, maps the institutional field of French social gerontology…

  5. Rheology of Crystallizing Basalts from Mt. Nyiragongo and Mt. Nyamuragira D.R.C.

    NASA Astrophysics Data System (ADS)

    Morrison, A. A.; Whittington, A. G.; Sehlke, A.

    2015-12-01

    Mt. Nyiragongo, located within the Virunga Volcanic Province on the western branch of the East African Rift, is known for its persistent lava lake activity as well as devastating eruptions in 1977 and 2002. The 2002 eruption caused a humanitarian crisis when channelized lava flows entered the nearby city of Goma killing 170 people and displacing ~350,000 others. These lavas have extremely low silica contents (39-42 wt.% SiO2) and are very fluid, allowing flows to move rapidly away from the source. We have measured the rheology of lavas from Nyiragongo using a concentric cylinder viscometer at temperatures of ~1220, 1205, 1190, 1175, 1165, and 1145°C. Each experiment starts with a liquid viscosity measurement at 1500˚C, followed by cooling to the desired experimental temperature. The lava spends 10-12 hours at this temperature, with constant stirring, before measurements begin. After measuring at a range of strain rates, the lava is quenched by immersion of the Pt crucible in a water bath. The viscosity is ~32 Pas at the liquidus temperature of ~1220°C, increasing gradually to ~142 Pas at 1165˚C. These viscosity measurements are much lower than most other basaltic compositions including Hawaiian lavas which have a crystal fraction of ~42% and apparent viscosity of ~2000 Pas at 1169°C. Over this temperature range, crystal fraction varies little (1-5% spinel crystals). Interpolating between measurements of the melt viscosity by concentric cylinder and parallel-plate viscometry suggests that at 1165˚C, the viscosity of the starting melt would be ~63 Pas. Consequently, the change in viscosity is due primarily to cooling rather than either the physical or chemical effects of crystallization. The data were collected at strain rates between ~1 and 46 s-1, and are well reproduced using a power-law model with exponents ~0.94 to 0.96. Below 1165˚C, crystal fraction and magma viscosity both increase rapidly. Further experiments at lower temperatures will quantify this

  6. Mitochondrial disease in childhood: mtDNA encoded.

    PubMed

    Saneto, Russell P; Sedensky, Margret M

    2013-04-01

    Since the first description of a mitochondrial DNA (mtDNA)-associated disease in the late 1980s, there have been more than 275 mutations within the mtDNA genome described causing human disease. The phenotypic expression of these disorders is vast, as disturbances of the unique physiology of mitochondria can create a wide range of clinical heterogeneity. Features of heteroplasmy, threshold effect, genetic bottleneck, mtDNA depletion, mitotic segregation, and maternal inheritance have been identified and described as a result of novel biochemical and genetic controls of mitochondrial function. We hope that as we unfold this fascinating part of clinical medicine, the reader will see how alterations in the tapestry of mitochondrial biochemistry and genetics can give rise to human illness.

  7. Gravity survey of the Mt. Toondina impact structure, South Australia

    NASA Technical Reports Server (NTRS)

    Plescia, J. B.; Shoemaker, E. M.; Shoemaker, C. S.

    1991-01-01

    The Mt. Toondina impact structure is located in northern South Australia, about 45 km south of the town of Oodnadatta. Only the central uplift is exposed. The outcrops at Mt. Toondina reveal a remarkable structural anomaly surrounded by a broad expanse of nearly flat-lying beds of the Bulldog Shale of Early Cretaceous age. A gravity survey was undertaken in 1989 to determine the diameter of the impact structure, define the form of the central uplift, and understand the local crustal structure. Data were collected along two orthogonal lines across the structure. In addition to the profiles, a significant number of measurements were made on and around the central uplift. The 1989 gravity data combined with 1963 gravity data and the seismic reflection data provide an excellent data base to interpret the subsurface structure of the Mt. Toondina feature.

  8. EMT and EndMT: regulated in similar ways?

    PubMed

    Saito, Akira

    2013-06-01

    Epithelial-mesenchymal transition (EMT) is an evolutionary conserved developmental process, which is evoked during tumour invasion and metastasis. In the tumour microenvironment, a variety of resident and recruited cells participate in tumour progression. Kawata et al. demonstrated an experimental model where proinflammatory cytokines derived from macrophages could enhance EMT of cancer cells. Endothelial-mesenchymal transition (EndMT) is originally observed during heart development, and recent studies suggest its role in pathological settings such as cancer and fibrosis. Mihira et al. demonstrated a line of evidence showing endothelial cell plasticity to undergo EndMT in vitro. Both in EMT and EndMT, transforming growth factor-β played pivotal roles, and multiple downstream mechanisms were used, depending on cell context. These recent works unraveled discrete regulatory networks in mesenchymal transition of epithelial and endothelial cells.

  9. MtDNA ancestry of Rio de Janeiro population, Brazil.

    PubMed

    Bernardo, Suellen; Hermida, Rose; Desidério, Márcia; Silva, Dayse A; de Carvalho, Elizeu F

    2014-01-01

    Polymorphism studies concerning HVI and HVII regions of mitochondrial DNA (mtDNA) have improved the understanding of the admixture genetic process related to the occupation of the continents by human population groups. We have analyzed the mtDNA lineages of 190 healthy and maternally unrelated individuals born in the metropolitan region of the Rio de Janeiro city, the capital of the State of Rio de Janeiro, southeastern Brazil. The data showing that 57.9, 25.3 and 16.8 % of the matrilineages found in Rio de Janeiro come from African, Amerindian and European population groups. They are, respectively, in close agreement with historical records which indicate that the admixture population of Brazil is the resulting of interethnic asymmetry crosses between individuals from those population groups. The high proportion of African mtDNA lineages in the population of Rio de Janeiro is in accordance with studies related to other Brazilian states.

  10. Genetic analysis of the presumptive blood from Louis XVI, King of France.

    PubMed

    Lalueza-Fox, Carles; Gigli, Elena; Bini, Carla; Calafell, Francesc; Luiselli, Donata; Pelotti, Susi; Pettener, Davide

    2011-11-01

    A text on a pyrographically decorated gourd dated to 1793 explains that it contains a handkerchief dipped with the blood of Louis XVI, king of France, after his execution. Biochemical analyses confirmed that the material contained within the gourd was blood. The mitochondrial DNA (mtDNA) hypervariable region 1 (HVR1) and 2 (HVR2), the Y-chromosome STR profile, some autosomal STR markers and a SNP in HERC2 gene associated to blue eyes, were retrieved, and some results independently replicated in two different laboratories. The uncommon mtDNA sequence retrieved can be attributed to a N1b haplotype, while the novel Y-chromosome haplotype belongs to haplogroup G2a. The HERC2 gene showed that the subject analyzed was a heterozygote, which is compatible with a blue-eyed person, as king Louis XVI was. To confirm the identity of the subject, an analysis of the dried heart of his son, Louis XVII, could be undertaken.

  11. The eruptive history of the Trous Blancs pit craters, La Réunion Island: The origin of a 24 km long lava flow

    NASA Astrophysics Data System (ADS)

    Walther, Georg; Frese, Ingmar; Di Muro, Andrea; Kueppers, Ulrich; Michon, Laurent; Métrich, Nicole

    2015-04-01

    The assessment of volcanic hazards is strongly based on the past eruptive behaviour of volcanoes and its morphological parameters. Since past eruption characteristics and their frequency provide the best probabilities of such eruptions for the future, understanding the complete eruptive history of a volcano is one of the most powerful tools in assessing the potential hazards or eruptions. At Piton de la Fournaise (PdF) volcano (La Réunion, Indian Ocean), the most frequent style of activity is the effusion of lava flows, which pose the greatest hazard by invasion of inhabited areas and destruction of human property. Here we examined the eruptive history of a previously uninvestigated area, believed to be the origin of a 24 km long lava flow. The eruptions recurrence time of PdF is about one eruption every 9 months in the central caldera. Besides this central activity, eruptive vents have been built along three main rift zones cutting the edifice during the last 50 kyrs. In this study we focused on the largest rift zone of about 15 km width and 20 km length, which extends in a north westerly direction between PdF and the nearby Piton des Neiges volcanic complex. This rift zone is typified by deep seismicity (up to 30 km), emitting mostly primitive magmas, indicative of high fluid pressures (up to 5 kbar) and large volume eruptions. Our area of investigation focused on four consecutively aligned pit craters called the Trous Blancs. These have been identified [1] as the source area of one of the youngest (ca. 6 kyrs) and largest lava field, which extends for 24 km from a height of 1800m asl, passing Le Tampon and Saint Pierre city, until it reaches the coast. To gain insight into the development of this eruption and possible future similar activity, we collected new field data (including stratigraphic logs, a geological map of the area, C-14 dating and geochemical analyses of the eruptive products). Fieldwork revealed that the eruption initiated with intense

  12. Passive monitoring of Mt. Etna and Mt. Yasur to probe the upper atmosphere

    NASA Astrophysics Data System (ADS)

    Assink, J. D.; Le Pichon, A.; Blanc, E.

    2013-12-01

    We present two case studies in which the influence of atmospheric dynamics on infrasound propagation is studied. We make use of a volcanic infrasound data set that has been recorded at infrasound arrays in the vicinity of Mount Etna, Italy (37 N). In addition, we revisit the Mt. Yasur (22 S) dataset. Respectively, over 6 and 10 years of infrasound observables are compared to theoretical estimates obtained from propagation modeling using existing European Centre for Medium-Range Weather Forecasts (ECMWF) atmospheric databases. Long-term detail comparisons such as presented in this study have been unprecedented and are useful for atmospheric modeling and infrasound propagation studies. While a first-order agreement is found, we report on significant discrepancies around the equinox period and during intervals during which anomalous detections occur during the winter, such as during Sudden Stratospheric Warmings (SSWs). We present an inversion study in which we make use of measured trace velocity estimates to predict effective sound speed model updates in a Bayesian framework. Such estimates will be compared to independent wind and temperature measurements that are available through the Atmospheric dynamics Research InfraStructure in Europe (ARISE) network.

  13. Mt. Etna: rationale and implementation of a Supersite

    NASA Astrophysics Data System (ADS)

    Puglisi, Giuseppe

    2017-04-01

    Mt. Etna is one of the most active volcanoes on Earth and, in the past few decades, has erupted virtually every year. The volcanism of Mt. Etna results from the interaction between magma ascent in the rather complex plumbing feeding system and the local tectonic regime controlled by the volcano edifice's eastern flank instability, whose driving conditions (e.g., structural setting, tectonic forces) and cause-effect relationships are not yet completely understood. At the surface, the combination of the two factors produces eruptions that might consist of either strongly explosive (e.g., 2002; 2011) and produce volcanic ash plumes likely to disrupt air traffic for hours to weeks (e.g., 5 January 2012), including powerful summit paroxysms in the 2012-2013 time span or lava flows capable of invading the populated sectors, that can threat human property and vital infrastructures. Mt. Etna presents many characteristics that make it prone to be a Geohazard Supersite. The volcano consists of an open-vent system characterised by continuous degassing from the volcano summit craters and frequent eruptive summit and flank eruptions. Eruptions can be of different kinds passing from violent short-lasting explosive events to long-lasting lava output, thus producing different kinds of impacts on the surrounding environment, and especially on the large number of people living around the volcano foot. Over time, the frequency and variety of Mt. Etna's eruptive activity have made the volcano one of the most well-studied and monitored worldwide. At Mt. Etna volcanic activity produces a wide spectrum of signals, spanning from seismic and geodetic to geochemical and radiometric signals, which are tracked in continuous and in real-and quasi-real time by the automatic multi-disciplinary monitoring systems deployed by INGV. The huge amount of ground-based collected data sets enforces the vision of Mt. Etna supersite as a Geohazard Supersite where applying the overarching criteria of the

  14. A new perspective in Oral health: potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity.

    PubMed

    Cutando, Antonio; Aneiros-Fernández, Jose; López-Valverde, Antonio; Arias-Santiago, Salvador; Aneiros-Cachaza, Jose; Reiter, Russel J

    2011-10-01

    Melatonin is involved in many physiological processes in mammals, amongst others; it is implicated in sleep-wake regulation. It has antioxidant and anti-inflammatory properties. It also acts as an immunomodulator, stimulates bone metabolism and inhibits various tumours. Additionally an abnormal melatonin rhythm may contribute to depression and insomnia. The mechanisms of action of melatonin include the involvement of membrane receptors (MT1, MT2), cytosolic binding sites (MT3 and calmodulin), and nuclear receptors of the RZR/ROR family. Melatonin also has receptor-independent activity and can directly scavenge free radicals. The current review addresses the functions of melatonin in the oral cavity in relation to its receptors. An extensive search was conducted on the following scientific databases Pub Med, Science Direct, ISI Web of Knowledge and Cochrane database in order to review all pertinent literature. Melatonin from the blood into the saliva may play an important role in suppressing oral diseases. It may have beneficial effects in periodontal disease, herpes and oral cancer, amongst others. Melatonin contributes to protecting of oral cavity from tissue damage due to its action of different receptors. From the reviewed literature it is concluded that experimental evidence suggests that melatonin can be useful in treating several common diseases of the oral cavity. Specific studies are necessary to extend the therapeutic possibilities of melatonin to other oral diseases. Copyright © 2011 Elsevier Ltd. All rights reserved.

  15. Melatonin influences somatostatin secretion from human pancreatic δ-cells via MT1 and MT2 receptors.

    PubMed

    Zibolka, Juliane; Mühlbauer, Eckhard; Peschke, Elmar

    2015-03-01

    Melatonin is an effector of the diurnal clock on pancreatic islets. The membrane receptor-transmitted inhibitory influence of melatonin on insulin secretion is well established and contrasts with the reported stimulation of glucagon release from α-cells. Virtually, nothing is known concerning the melatonin-mediated effects on islet δ-cells. Analysis of a human pancreatic δ-cell model, the cell line QGP-1, and the use of a somatostatin-specific radioimmunoassay showed that melatonin primarily has an inhibitory effect on somatostatin secretion in the physiological concentration range. In the pharmacological range, melatonin elicited slightly increased somatostatin release from δ-cells. Cyclic adenosine monophosphate (cAMP) is the major second messenger dose-dependently stimulating somatostatin secretion, in experiments employing the membrane-permeable 8-Br-cAMP. 8-Br-cyclic guanosine monophosphate proved to be of only minor relevance to somatostatin release. As the inhibitory effect of 1 nm melatonin was reversed after incubation of QGP-1 cells with the nonselective melatonin receptor antagonist luzindole, but not with the MT2-selective antagonist 4-P-PDOT (4-phenyl-2-propionamidotetraline), an involvement of the MT1 receptor can be assumed. Somatostatin release from the δ-cells at low glucose concentrations was significantly inhibited during co-incubation with 1 nm melatonin, an effect which was less pronounced at higher glucose levels. Transient expression experiments, overexpressing MT1, MT2, or a deletion variant as a control, indicated that the MT1 and not the MT2 receptor was the major transmitter of the inhibitory melatonin effect. These data point to a significant influence of melatonin on pancreatic δ-cells and on somatostatin release.

  16. Identifying Water on Mt. Baker and Mt. St. Helens, WA with Geophysics: Implications for Volcanic Landslide Hazards

    NASA Astrophysics Data System (ADS)

    Finn, C.; Bedrosian, P.; Wisniewski, M.; Deszcz-Pan, M.

    2015-12-01

    Groundwater position, abundance, and flow rates within a volcano affect the transmission of fluid pressure, transport of mass and heat and formation of mechanically weak hydrothermal alteration influencing the stability of volcanoes. In addition, eruptions can shatter volcanic rocks, weakening the edifice. Helicopter magnetic and electromagnetic (HEM) data collected over Mt. Baker and Mt. St. Helens volcanoes reveal the distribution of water, shattered volcanic rocks and hydrothermal alteration essential to evaluating volcanic landslide hazards. These data, combined with geological mapping and rock property measurements, indicate the presence of localized <100 m thick zones of water-saturated hydrothermally altered rock beneath Sherman Crater and the Dorr Fumarole Fields at Mt. Baker. Nuclear magnetic resonance data indicate that the hydrothermal clays contain ~50% bound water with no evidence for free water ponded beneath the ice. The HEM data suggest water-saturated fresh volcanic rocks from the surface to the detection limit (~100 m) over the entire summit of Mt. Baker (below the ice). A 50-100 m thick high resistivity layer (>1500 ohm-m) corresponding to domes, debris avalanche, volcanic rocks and glaciers mantles the crater at Mt. St. Helens. Shallow low resistivity layers corresponding to fresh, cold water and hot brines are observed below the high resistivity surface in EM data. Shallow ground water mainly concentrates in shattered dome material in the crater of Mt. St. Helens. Aeromagnetic data indicate the location of basalts sandwiched between debris avalanche deposits and shattered dome material. The combination of the EM and magnetic data help map the location of the shattered dome material that is considered to be the failure surface for the 1980 debris avalanche. The EM data image the regional groundwater table near the base of the volcano. The geophysical identification of groundwater and weak layers constrain landslide hazards assessments.

  17. Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration

    PubMed Central

    Khiati, Salim; Baechler, Simone A.; Factor, Valentina M.; Zhang, Hongliang; Huang, Shar-yin N.; Dalla Rosa, Ilaria; Sourbier, Carole; Neckers, Leonard; Thorgeirsson, Snorri S.; Pommier, Yves

    2015-01-01

    The liver has an exceptional replicative capacity following partial hepatectomy or chemical injuries. Cellular proliferation requires increased production of energy and essential metabolites, which critically depend on the mitochondria. To determine whether Top1mt, the vertebrate mitochondrial topoisomerase, is involved in this process, we studied liver regeneration after carbon tetrachloride (CCl4) administration. TOP1mt knockout (KO) mice showed a marked reduction in regeneration and hepatocyte proliferation. The hepatic mitochondrial DNA (mtDNA) failed to increase during recovery from CCl4 exposure. Reduced glutathione was also depleted, indicating increased reactive oxygen species (ROS). Steady-state levels of ATP, O2 consumption, mtDNA, and mitochondrial mass were also reduced in primary hepatocytes from CCl4-treated KO mice. To further test whether Top1mt acted by enabling mtDNA regeneration, we tested TOP1mt KO fibroblasts and human colon carcinoma HCT116 cells and measured mtDNA after 3-d treatment with ethidium bromide. Both types of TOP1mt knockout cells showed defective mtDNA regeneration following mtDNA depletion. Our study demonstrates that Top1mt is required for normal mtDNA homeostasis and for linking mtDNA expansion with hepatocyte proliferation. PMID:26305952

  18. Young people's heroes in France and Spain.

    PubMed

    Gash, Hugh; Domínguez Rodríguez, Pilar

    2009-05-01

    Heroes play collectivist or individualist roles in imagination and self-development. Representations of heroic figures in questionnaires given to French (n = 241) and Spanish (n = 227) samples of 10 and 15-year-olds were examined to assess the extent that heroes originated in digital media, and whether they were proximal or distal personalities. There is strong evidence that heroes in this sample were largely learned about in digital media (France 45%, Spain 50%): family and community heroes were a minority (France 11%, Spain 9%). Male heroes were more important to Spanish participants compared to their French peers. The acquisition sequence for hero type reported in the pre-television era, proximal (family and community) to distal (beyond the neighbourhood), is reversed in this study. Generally, 10-year-olds preferred heroes with collectivist qualities and 15-year-olds with individualised qualities. Findings are discussed in terms of the emergence of social capital.

  19. Diphtheria: a zoonotic disease in France?

    PubMed

    Bonmarin, Isabelle; Guiso, Nicole; Le Flèche-Matéos, Anne; Patey, Olivier; Patrick, A D Grimont; Levy-Bruhl, Daniel

    2009-06-24

    Thanks to vaccination, diphtheria has almost disappeared in France. The case definition, used for mandatory notification, was expanded in 2003 to include toxin-producing strains of Corynebacterium ulcerans. We describe the epidemiology of diphtheria in France from 1990 to 2008. No cases occurred between 1990 and 2001. Since 2002, 19 cases have been reported: 4 cases due to Corynebacterium diphtheriae related to exposure in endemic countries, and 15 cases due to other corynebacteria, including 4 cases of pseudomembranous pharyngitis, mainly related to contact with domestic animals. High vaccination coverage in the population and sensitive surveillance need to be maintained. Moreover, control measures need to be adapted to the non-C. diphtheriae toxigenic species.

  20. Modeling the Historical Flood Events in France

    NASA Astrophysics Data System (ADS)

    Ali, Hani; Blaquière, Simon

    2017-04-01

    We will present the simulation results for different scenarios based on the flood model developed by AXA Global P&C CAT Modeling team. The model uses a Digital Elevation Model (DEM) with 75 m resolution, a hydrographic system (DB Carthage), daily rainfall data from "Météo France", water level from "HYDRO Banque" the French Hydrological Database (www.hydro.eaufrance.fr), for more than 1500 stations, hydrological model from IRSTEA and in-house hydraulic tool. In particular, the model re-simulates the most important and costly flood events that occurred during the past decade in France: we will present the re-simulated meteorological conditions since 1964 and estimate insurance loss incurred on current AXA portfolio of individual risks.

  1. First case of human gongylonemosis in France

    PubMed Central

    Pesson, Bernard; Hersant, Christel; Biehler, Jean-François; Abou-Bacar, Ahmed; Brunet, Julie; Pfaff, Alexander W.; Ferté, Hubert; Candolfi, Ermanno

    2013-01-01

    Gongylonema spp. are cosmopolitan spirurid nematodes that are common parasites of wild and domesticated mammals and birds. Gongylonema pulchrum Molin, 1857 is most common in ruminants, where it invades mucosa and submucosa of the mouth, tongue, oesophagus and forestomachs. It extremely rarely occurs in man, and fewer than 60 cases have been reported worldwide. We report a case from the Alsace region, which appears to be the first case of human gongylonemosis described in France. PMID:23425508

  2. First case of human gongylonemosis in France.

    PubMed

    Pesson, Bernard; Hersant, Christel; Biehler, Jean-François; Abou-Bacar, Ahmed; Brunet, Julie; Pfaff, Alexander W; Ferté, Hubert; Candolfi, Ermanno

    2013-01-01

    Gongylonema spp. are cosmopolitan spirurid nematodes that are common parasites of wild and domesticated mammals and birds. Gongylonema pulchrum Molin, 1857 is most common in ruminants, where it invades mucosa and submucosa of the mouth, tongue, oesophagus and forestomachs. It extremely rarely occurs in man, and fewer than 60 cases have been reported worldwide. We report a case from the Alsace region, which appears to be the first case of human gongylonemosis described in France.

  3. Enterovirus Migration Patterns between France and Tunisia.

    PubMed

    Othman, Ines; Mirand, Audrey; Slama, Ichrak; Mastouri, Maha; Peigue-Lafeuille, Hélène; Aouni, Mahjoub; Bailly, Jean-Luc

    2015-01-01

    The enterovirus (EV) types echovirus (E-) 5, E-9, and E-18, and coxsackievirus (CV-) A9 are infrequently reported in human diseases and their epidemiologic features are poorly defined. Virus transmission patterns between countries have been estimated with phylogenetic data derived from the 1D/VP1 and 3CD gene sequences of a sample of 74 strains obtained in France (2000-2012) and Tunisia (2011-2013) and from the publicly available sequences. The EV types (E-5, E-9, and E-18) exhibited a lower worldwide genetic diversity (respective number of genogroups: 4, 5, and 3) in comparison to CV-A9 (n = 10). The phylogenetic trees estimated with both 1D/VP1 and 3CD sequence data showed variations in the number of co-circulating lineages over the last 20 years among the four EV types. Despite the low number of genogroups in E-18, the virus exhibited the highest number of recombinant 3CD lineages (n = 10) versus 4 (E-5) to 8 (E-9). The phylogenies provided evidence of multiple transportation events between France and Tunisia involving E-5, E-9, E-18, and CV-A9 strains. Virus spread events between France and 17 other countries in five continents had high probabilities of occurrence as those between Tunisia and two European countries other than France. All transportation events were supported by BF values > 10. Inferring the source of virus transmission from phylogenetic data may provide insights into the patterns of sporadic and epidemic diseases caused by EVs.

  4. Screening programme for congenital toxoplasmosis in France.

    PubMed

    Thulliez, P

    1992-01-01

    The high prevalence of Toxoplasma gondii infection in France led to the establishment of a national screening programme. Preventive measures were progressively introduced, and these became compulsory in 1978 with the result that the incidence of congenital toxoplasmosis is now markedly reduced. Further improvements may include more systematic sampling from women before pregnancy, better and adequate health education and centralized notification of both maternal and congenital cases of toxoplasmosis.

  5. Minimally Invasive Forefoot Surgery in France.

    PubMed

    Meusnier, Tristan; Mukish, Prikesht

    2016-06-01

    Study groups have been formed in France to advance the use of minimally invasive surgery. These techniques are becoming more frequently used and the technique nuances are continuing to evolve. The objective of this article was to advance the awareness of the current trends in minimally invasive surgery for common diseases of the forefoot. The percutaneous surgery at the forefoot is less developed at this time, but also will be discussed.

  6. [Suicide in France, a situational analysis].

    PubMed

    Facy, Françoise

    2017-04-01

    The fall in the number of suicides in France in no way diminishes the urgent need to act and reinforce the efforts, initiatives and resources to fight against this human tragedy. Public policies are starting to show results. The action of the French national suicide watch, associations, health professionals as well as the perspectives of the French national mental health council should amplify this movement. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  7. Enterovirus Migration Patterns between France and Tunisia

    PubMed Central

    Othman, Ines; Mirand, Audrey; Slama, Ichrak; Mastouri, Maha; Peigue-Lafeuille, Hélène; Aouni, Mahjoub; Bailly, Jean-Luc

    2015-01-01

    The enterovirus (EV) types echovirus (E-) 5, E-9, and E-18, and coxsackievirus (CV-) A9 are infrequently reported in human diseases and their epidemiologic features are poorly defined. Virus transmission patterns between countries have been estimated with phylogenetic data derived from the 1D/VP1 and 3CD gene sequences of a sample of 74 strains obtained in France (2000–2012) and Tunisia (2011–2013) and from the publicly available sequences. The EV types (E-5, E-9, and E-18) exhibited a lower worldwide genetic diversity (respective number of genogroups: 4, 5, and 3) in comparison to CV-A9 (n = 10). The phylogenetic trees estimated with both 1D/VP1 and 3CD sequence data showed variations in the number of co-circulating lineages over the last 20 years among the four EV types. Despite the low number of genogroups in E-18, the virus exhibited the highest number of recombinant 3CD lineages (n = 10) versus 4 (E-5) to 8 (E-9). The phylogenies provided evidence of multiple transportation events between France and Tunisia involving E-5, E-9, E-18, and CV-A9 strains. Virus spread events between France and 17 other countries in five continents had high probabilities of occurrence as those between Tunisia and two European countries other than France. All transportation events were supported by BF values > 10. Inferring the source of virus transmission from phylogenetic data may provide insights into the patterns of sporadic and epidemic diseases caused by EVs. PMID:26709514

  8. The e-Bug project in France.

    PubMed

    Touboul, Pia; Dunais, Brigitte; Urcun, Jeanne-Marie; Michard, Jean-Louis; Loarer, Christian; Azanowsky, Jean-Michel; Vincent, Isabelle; Jestin, Christine; Housseau, Bruno; de Warren, Anne; Dellamonica, Pierre

    2011-06-01

    The high rates of antibiotic prescriptions and antimicrobial resistance in France motivated its participation in the European e-Bug school project concerning microbes, and infection transmission, prevention and treatment. The prospect of raising awareness among children, helping them to adopt suitable attitudes and behaviour towards infection transmission and treatment starting from childhood, generated enthusiastic support from relevant national educational and health institutions throughout the Project. France was actively involved in every stage: background research showed that the subject matter was best suited to the national science curricula of the fourth and fifth forms in junior schools, and the sixth and ninth forms in senior schools; a focus group study with junior and senior teachers elicited teachers' needs concerning teaching resources; and a qualitative and quantitative evaluation, after translation and pack review, enabled further adaptation of the packs. This evaluation showed an overall enthusiastic reception by teachers and their students in France, and reassured teachers on the ease of use of the Project's resources and students' progress. The e-Bug Project was launched through a national institutional implementation plan in September 2009 and orders for e-Bug tools increased rapidly. By the end of October, 57% of all senior science teachers and 16% of all junior school teachers had ordered the pack. France is one of the most frequent users of the e-Bug web site. The collaboration with both educational and health partners was particularly helpful to implementing the Project, and this was confirmed by the favourable reception and participation of teachers and students in the field.

  9. [New conditions for organ donation in France].

    PubMed

    Antoine, Corinne; Maroudy, Daniel

    2016-09-01

    The procurement of organs from donors after circulatory death is a reliable technique which gives satisfactory posttransplant results and also represents a potential source of additional organs. In order to meet the growing need for organ donations, the 'anticipated organ donation approach' procedure is currently receiving renewed interest with new conditions for its implementation in France. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  10. Frances Keesler Graham (1918-2013).

    PubMed

    Berg, W Keith

    2014-09-01

    Frances Keesler Graham, noted psychophysiologist and developmental researcher, died on April 16, 2013. Fran was born in Canastota, New York, on August 1, 1918. Fran's high-quality research, her success in obtaining 39 years of uninterrupted funding, and the very high regard in which she was held among her colleagues led to numerous awards and honors. Fran was demanding but equally willing to provide extensive assistance to students willing to work hard.

  11. Bioelectromagnetics Research in France--An Assessment.

    DTIC Science & Technology

    1984-06-29

    lEanetj’ hr black auf) Over the past decade, France has played a major research role In bicebec- tri~ gnetics (BEN) (studies of the interaction of...materials studied at CNRS; reasonable conclusion. Occupational use animal behavior and electroencephalogram of electromagnetic energy, on the oher...at slightly shorter A crossed -beam apparatus for treatment times and at slightly lower simultaneous spectrophotometric observa- final temperatures

  12. 76 FR 9991 - Television Broadcasting Services; Kalispell, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-23

    ... COMMISSION 47 CFR Part 73 Television Broadcasting Services; Kalispell, MT AGENCY: Federal Communications... ex parte contacts (other than ex parte presentations exempt under 47 CFR 1.1204(a)) are prohibited in Commission proceedings, such as this one, which involve channel allotments. See 47 CFR 1.1208 for...

  13. Mt. San Antonio College Matriculation Study: Fall 1986-Spring 1989.

    ERIC Educational Resources Information Center

    Hall, Barbara Ann; And Others

    In fall 1986, Mt. San Antonio College (MSAC) began a five year longitudinal study of the effectiveness of its matriculation services, which include assessment, orientation, counseling/advisement, and follow-up of students by staff members. The study utilized a computerized tracking system to compare retention, grade point average (GPA),…

  14. Mt. San Antonio College Matriculation Research Update, 1989-90.

    ERIC Educational Resources Information Center

    Hall, Barbara Ann; And Others

    In fall 1986, Mt. San Antonio College (MSAC) initiated a 5-year longitudinal study of the effectiveness of its matriculation services, including assessment, orientation, counseling/advisement, and follow-up. The academic performance and success of students participating in one or more of these services were compared to those of degree- and…

  15. Mt. San Antonio Community College Information Notebook; Volume Two, 1985.

    ERIC Educational Resources Information Center

    Mount San Antonio Community Coll. District, Walnut, CA.

    This databook contains some of the basic information to be used in decision making and planning in the Mt. San Antonio College (MSAC) District. Part I focuses on the demographic characteristics of the district population, feeder school districts, and data from other educational providers. Part II presents statewide data on potential enrollment by…

  16. Mt. St. Helens Seen Close Up on May 18.

    ERIC Educational Resources Information Center

    Stoffel, Dorothy B.; Stoffel, Keith L.

    1980-01-01

    Describes eruption steps in Mt. St. Helens' top surface deformation: constant shaking of earthquakes, minor steaming from vents, and sudden catastrophic eruption. Explosions caused black projectile-laden ash clouds, vertical white steam clouds, and vertical gray ash-laden clouds. (SK)

  17. 77 FR 41259 - Modification of Class E Airspace; Plentywood, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ..., which is incorporated by reference in 14 CFR 71.1. The Class E airspace designations listed in this... Federal Aviation Administration 14 CFR Part 71 Modification of Class E Airspace; Plentywood, MT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action modifies Class...

  18. Mt. Etna taken by the Expedition Two crew

    NASA Image and Video Library

    2001-07-22

    ISS002-E-9637 (22 July 2001) --- An overhead look at the smoke and ash being expelled from the erupting volcano Mt. Etna on the island of Sicily. This image was recorded by an Expedition Two crew member with a digital still camera.

  19. Mt. Etna taken by the Expedition Two crew

    NASA Image and Video Library

    2001-07-22

    ISS002-E-9639 (22 July 2001) --- An overhead look at the smoke and ash being expelled from the erupting volcano Mt. Etna on the island of Sicily. This image was recorded by an Expedition Two crew member with a digital still camera.

  20. Mt. St. Helens Seen Close Up on May 18.

    ERIC Educational Resources Information Center

    Stoffel, Dorothy B.; Stoffel, Keith L.

    1980-01-01

    Describes eruption steps in Mt. St. Helens' top surface deformation: constant shaking of earthquakes, minor steaming from vents, and sudden catastrophic eruption. Explosions caused black projectile-laden ash clouds, vertical white steam clouds, and vertical gray ash-laden clouds. (SK)

  1. Conflicting Values: Spirituality and Wilderness at Mt. Shasta

    Treesearch

    Maria Fernandez-Gimenez; Lynn Huntsinger; Catherine Phillips; Barbara Allen-Diaz

    1992-01-01

    Many people from a variety of backgrounds believe that Mt. Shasta is a major spiritual center. Although these "spiritual users" value the area's natural features, their spiritual and social activities, including construction of sweat lodges, medicine wheels, altars, meditation pads, trails, and campsites, are leading to rapid ecological degradation. This...

  2. Gravity Survey of the Mt. Toondina Impact Structure South Australia

    NASA Technical Reports Server (NTRS)

    Plescia, J.; Shoemaker, E.; Shoemaker, C.

    1993-01-01

    This paper presents data to support the conclusion that gravity data combined with seismic reflection data and surface stuctural geologic mapping for the Mt. Toondina structure in South Australia reveal that the central uplift is surrounded by a ring structural depression.

  3. Mt. San Antonio Community College Information Notebook; Volume Two, 1985.

    ERIC Educational Resources Information Center

    Mount San Antonio Community Coll. District, Walnut, CA.

    This databook contains some of the basic information to be used in decision making and planning in the Mt. San Antonio College (MSAC) District. Part I focuses on the demographic characteristics of the district population, feeder school districts, and data from other educational providers. Part II presents statewide data on potential enrollment by…

  4. Mt. San Antonio College Matriculation Research Update, 1989-90.

    ERIC Educational Resources Information Center

    Hall, Barbara Ann; And Others

    In fall 1986, Mt. San Antonio College (MSAC) initiated a 5-year longitudinal study of the effectiveness of its matriculation services, including assessment, orientation, counseling/advisement, and follow-up. The academic performance and success of students participating in one or more of these services were compared to those of degree- and…

  5. Mt. San Antonio College Matriculation Study: Fall 1986-Spring 1989.

    ERIC Educational Resources Information Center

    Hall, Barbara Ann; And Others

    In fall 1986, Mt. San Antonio College (MSAC) began a five year longitudinal study of the effectiveness of its matriculation services, which include assessment, orientation, counseling/advisement, and follow-up of students by staff members. The study utilized a computerized tracking system to compare retention, grade point average (GPA),…

  6. Mt. Etna, Sicily as seen from STS-62

    NASA Image and Video Library

    1994-03-05

    STS062-85-195 (4-18 March 1994) --- A thin plume of steam blows southward from the summit of Mt. Etna, the active volcano on the island of Sicily. The summit is capped with snow but the dark lava flow along the eastern flank (the 1991-93 flow) is clearly visible. The coastal city south of Etna is Catania.

  7. Motion-dependent representation of space in area MT+.

    PubMed

    Maus, Gerrit W; Fischer, Jason; Whitney, David

    2013-05-08

    How is visual space represented in cortical area MT+? At a relatively coarse scale, the organization of MT+ is debated; retinotopic, spatiotopic, or mixed representations have all been proposed. However, none of these representations entirely explain the perceptual localization of objects at a fine spatial scale--a scale relevant for tasks like navigating or manipulating objects. For example, perceived positions of objects are strongly modulated by visual motion; stationary flashes appear shifted in the direction of nearby motion. Does spatial coding in MT+ reflect these shifts in perceived position? We performed an fMRI experiment employing this "flash-drag" effect and found that flashes presented near motion produced patterns of activity similar to physically shifted flashes in the absence of motion. This reveals a motion-dependent change in the neural representation of object position in human MT+, a process that could help compensate for perceptual and motor delays in localizing objects in dynamic scenes. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. 76 FR 59479 - Montana Disaster Number MT-00062

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Montana Disaster Number MT-00062 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2... Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera, Associate Administrator for Disaster...

  9. Evidences for higher nocturnal seismic activity at the Mt. Vesuvius

    NASA Astrophysics Data System (ADS)

    Scafetta, Nicola; Mazzarella, Adriano

    2017-04-01

    We analyze hourly seismic data measured at the Osservatorio Vesuviano Ovest (OVO, 1972-2014) and at the Bunker Est (BKE, 1999-2014) stations on the Mt. Vesuvius (Italy). The OVO record is complete for seismic events with magnitude M ≥ 1.9. We demonstrate that before 1996 this record presents a daily oscillation that nearly vanishes afterwards. To determine whether a daily oscillation exists in the seismic activity of the Mt. Vesuvius, we use the higher quality BKE record that is complete for seismic events with magnitude M ≥ 0.2. We demonstrate that BKE confirms that the seismic activity at the Mt. Vesuvius is higher during nighttime than during daytime. The amplitude of the daily oscillation is enhanced during summer and damped during winter. We speculate possible links with the cooling/warming diurnal cycle of the volcanic edifice and with external geomagnetic field. We find that the amplitude of the seismic daily cycle changes in time and has been increasing since 2008. Finally, we propose a seismic activity index to monitor the 24-hour oscillation that could be used to complement other methodologies currently adopted to determine the seismic status of the volcano to prevent the relative hazard. Reference: Mazzarella, A., Scafetta, N., 2016. Evidences for higher nocturnal seismic activity at the Mt. Vesuvius. Journal of Volcanology and Geothermal Research 321, 102-113. DOI: 10.1016/j.jvolgeores.2016.04.026

  10. Limnology of Mt. Elbert Forebay, 1978-1979. Final report

    SciTech Connect

    Boehmke, J.R.; LaBounty, J.F.; Sartoris, J.J.; Roline, R.A.

    1982-03-01

    The 1978-79 limnological study of Mt. Elbert Forebay was done in conjunction with other limnological studies at Twin Lakes. The purpose of the overall study is to determine the effects of pumped storage on the aquatic environment of Twin Lakes. Information will help maximize ecological resources while meeting the water storage and power generation objectives of Fryingpan-Arkansas Project.

  11. 76 FR 53049 - Amendment of Class E Airspace; Shelby, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Shelby, MT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action modifies Class E airspace at... received. Class E airspace designations are published in paragraph 6005 of FAA Order 7400.9U dated...

  12. 77 FR 44120 - Establishment of Class E Airspace; Roundup, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Roundup, MT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class E... Association (NBAA). The NBAA comments recommended that the FAA lower some of the adjacent Class E...

  13. 77 FR 55690 - Amendment of Class E Airspace; Dillon, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Dillon, MT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E airspace... Federal Register a notice of proposed rulemaking (NPRM) to amend Class E airspace at Dillon...

  14. Southern Hemisphere Lidar Measurements of the Aerosol Clouds from Mt. Pinatubo and Mt. Hudson

    NASA Technical Reports Server (NTRS)

    Young, Stuart A.; Manson, Peter J.; Patterson, Graeme R.

    1992-01-01

    On 19 Jul., 1991, during tests to determine the ability of the newly-modified CSIRO Ns:YAG lidar to measure signals from the stratosphere before the arrival of dust from the eruption of Mt. Pinatubo, a strongly scattering layer was detected at an altitude of 2 km. That evening, the spectacular sunset and twilight were typical of volcanically disturbed conditions. Lidar measurements at 532 nm were made between 1400 and 1500 EST (0400-0500 UT) on 19 Jul. through broken cloud. Approximately 3800 laser firings were averaged in 256 shot blocks. These and subsequent data have been analyzed to produce profiles of aerosol volume backscatter function and scattering ratio. Clouds again prevented a clear view of the twilights on the next two nights, although there was some evidence for an enhanced glow. The evidence suggested that the aerosol layer had disappeared. An explanation for this disappearance and the earlier than expected arrival of the layer over Melbourne was required. Nimbus 7 TOMS data for 23 Jun. showed that the SO2 from the eruption had extended at least 11000 km to the west and that the southern boundary of the cloud had reached 15 degrees S just 8 days after the climactic eruption. It can be assumed that this cloud also contained dust and sulphuric acid aerosol. It was proposed that a section had then been broken away from the main cloud and carried south by a large scale eddy between the low latitude easterlies and the strong mid-latitude westerlies which finally carried the aerosol cloud over southern Australia. Accompanying 30 mb wind data showed a counter clockwise circulation, responsible for the transport, located in the South Atlantic Ocean.

  15. Southern Hemisphere Lidar Measurements of the Aerosol Clouds from Mt. Pinatubo and Mt. Hudson

    NASA Technical Reports Server (NTRS)

    Young, Stuart A.; Manson, Peter J.; Patterson, Graeme R.

    1992-01-01

    On 19 Jul., 1991, during tests to determine the ability of the newly-modified CSIRO Ns:YAG lidar to measure signals from the stratosphere before the arrival of dust from the eruption of Mt. Pinatubo, a strongly scattering layer was detected at an altitude of 2 km. That evening, the spectacular sunset and twilight were typical of volcanically disturbed conditions. Lidar measurements at 532 nm were made between 1400 and 1500 EST (0400-0500 UT) on 19 Jul. through broken cloud. Approximately 3800 laser firings were averaged in 256 shot blocks. These and subsequent data have been analyzed to produce profiles of aerosol volume backscatter function and scattering ratio. Clouds again prevented a clear view of the twilights on the next two nights, although there was some evidence for an enhanced glow. The evidence suggested that the aerosol layer had disappeared. An explanation for this disappearance and the earlier than expected arrival of the layer over Melbourne was required. Nimbus 7 TOMS data for 23 Jun. showed that the SO2 from the eruption had extended at least 11000 km to the west and that the southern boundary of the cloud had reached 15 degrees S just 8 days after the climactic eruption. It can be assumed that this cloud also contained dust and sulphuric acid aerosol. It was proposed that a section had then been broken away from the main cloud and carried south by a large scale eddy between the low latitude easterlies and the strong mid-latitude westerlies which finally carried the aerosol cloud over southern Australia. Accompanying 30 mb wind data showed a counter clockwise circulation, responsible for the transport, located in the South Atlantic Ocean.

  16. [Epidemiology of urogenital cancers in France].

    PubMed

    Rébillard, Xavier; Tretarre, Brigitte

    2007-03-31

    Estimates of cancer incidence and mortality in France as well as survival data are published by the cancer registry network (Francim). In 2000, the number of new cancer cases was almost 280,000 in France. This number has been gradually increasing, partly due to population aging. The proportion of urological cancers is increasing as well, as a consequence of the marked increase in number of prostate cancers. The estimated number of new cases for the 4 main urological cancers in 2000 reached 61,174, distributed as follows: 40,310 prostate cancers, 10,771 bladder cancers, 8,293 kidney cancers and 1,800 testis cancers. Urological tumours represented at the time 22% of new cancer cases in France: 35% of male cancers (56,402 /161,025) and 4% of female cancers (4,772/117,228). The relative five-year survival for prostate cancers is high: 80%. It is below that of testis cancers (95% after 5 years), but higher than that of kidney cancers (64% in men and 63% in women after five years). Of all urological cancers, bladder cancers have the worst prognosis, since the relative five-year survival is 60% in men and especially 50% in women.

  17. Mosquito spiroplasmas from France and their ecology.

    PubMed

    Chastel, C; Devau, B; Le Goff, F; Simitzis-Le Flohic, A M; Gruffaz, R; Kerdraon, G; Gilot, B

    1987-06-01

    Spiroplasmas have been isolated previously from a number of blood-sucking arthropods, including ticks, horseflies, and deerflies. More recently, spiroplasmas were isolated from mosquitoes from the USA, France, and Taiwan. Spiroplasmas isolated from mosquitoes from France belong to at least three serogroups and are serologically different from one of the Taiwan isolates, Sp2. Our Ar 1343 strain is the prototype of a new serogroup (XIII). During 3 consecutive years (1983-85), the ecology of these spiroplasmas was studied in different biotopes near, and in, the Isère River Valley in Savoia, France. A total of 23 strains was isolated from four species or groups of mosquitoes (Aedes sticticus/vexans, Ae. cantans/annulipes, Ae. cinereus/geminus and Coquillettidia richiardii). Spiroplasmas were isolated only from female mosquitoes and only during June and July. An as yet unidentified virus was also isolated from three mosquito pools, one of which yielded spiroplasmas. Spiroplasma viruses were not detected. Antibody to our Ar 1357 isolate was found in 4 of 20 sera from cows living in the areas studied, but not in sera from wild rodents or in sera from rabbit or pigeon sentinels. Finally, preliminary results are presented on the effects of experimental infection of Ae. aegypti with the Ar 1357 isolated (serogroup XXII).

  18. A paradox in physics education in France

    NASA Astrophysics Data System (ADS)

    Smigiel, Eddie; Sonntag, Michel

    2013-07-01

    This paper deals with the nature and the level of difficulty of teaching and learning physics in the first year of undergraduate engineering schools in France. Our case study is based on a survey regarding a classic and basic question in applied physics, and which was conducted with a group of second-year students in a post-baccalaureateThe French baccalaureate (baccalauréat) is the examination students must pass to graduate from high school. undergraduate engineering school. The responses to the survey indicate that many students fall into a kind of mathematical ‘formalism’, which prevents them from understanding the actual physics behind the question. This leads us to believe that we must reconsider the way that physics is taught. An analysis of a physics teaching sequence in French and English undergraduate textbooks confirms the weight given to mathematical formalism in France. When approached from a purely mathematical angle, physics becomes a long and slow process of assimilation of the specific scientific culture that underlies the teaching model used in classes préparatoires, classes that are usually presented as a model of academic excellence. However, this model appears to be less suitable when teaching more ‘ordinary students’, who respond better when taken through a ‘detour’ of the ‘important roots’ of physics. This paper shows that in France historically rooted pedagogical traditions persist, ignoring the latest advances in research on science teaching.

  19. Populations at Risk for Alveolar Echinococcosis, France

    PubMed Central

    Piarroux, Martine; Piarroux, Renaud; Knapp, Jenny; Bardonnet, Karine; Dumortier, Jérôme; Watelet, Jérôme; Gerard, Alain; Beytout, Jean; Abergel, Armand; Bresson-Hadni, Solange

    2013-01-01

    During 1982–2007, alveolar echinococcosis (AE) was diagnosed in 407 patients in France, a country previously known to register half of all European patients. To better define high-risk groups in France, we conducted a national registry-based study to identify areas where persons were at risk and spatial clusters of cases. We interviewed 180 AE patients about their way of life and compared responses to those of 517 controls. We found that almost all AE patients lived in 22 départements in eastern and central France (relative risk 78.63, 95% CI 52.84–117.02). Classification and regression tree analysis showed that the main risk factor was living in AE-endemic areas. There, most at-risk populations lived in rural settings (odds ratio [OR] 66.67, 95% CI 6.21–464.51 for farmers and OR 6.98, 95% CI 2.88–18.25 for other persons) or gardened in nonrural settings (OR 4.30, 95% CI 1.82–10.91). These findings can help sensitization campaigns focus on specific groups. PMID:23647623

  20. Transformation of MT Resistivity Sections into Geologically Meaningful Images

    NASA Astrophysics Data System (ADS)

    Park, S. K.

    2004-05-01

    Earthscope offers an unprecedented opportunity for interdisciplinary studies of North America. In addition to a continent-wide seismic study, it includes the acquisition of magnetotelluric (MT) data at many of the Bigfoot array sites. Earthscope will thus provide a uniform 3-D MT survey over regional scales when completed. MT interpreters will be able to include 3-D regional effects in their models for the first time whether they are interpreting local studies. However, the full value of the interdisciplinary nature of Earthscope will be realized only if MT sections and maps are useful to other earth scientists. The standard final product from any 2-D or 3-D MT interpretation is a spatial distribution of electrical resistivity. Inference of the physicochemical state from bulk resistivity is complicated because a variety of factors influence the property including temperature, intrinsic conduction of silicates, and small amounts of interconnected conducting materials (e.g., graphite, metallic minerals, partial melt, fluid). Here, I use petrophysical measurements and a petrological model to transform a resistivity section into cross sections of temperature and partial melt fraction in the mantle beneath the Sierra Nevada. In this manner, I am able to separate the contributions of increasing temperature and melt fraction to the bulk resistivity. Predicted melt fractions match observations from xenoliths relatively well but temperatures are systematically 200C higher than those observed. A small amount of dissolved hydrogen (~70 ppm H/Si) lowers the predicted temperatures to match those from the xenoliths, however. I conclude that while this transformation is a simple first step based on many assumptions, initial results are promising.

  1. Moisture Sources for Snowfall to Mt. Logan, Yukon

    NASA Astrophysics Data System (ADS)

    Rupper, S. R.; Steig, E. J.

    2002-05-01

    Accumulation and isotopic data from an ice core obtained at Mt. Logan, Yukon Territory (Holdsworth et al, 1992) are used to determine possible sources of precipitation at the site, an important prerequisite to the use of Mt. Logan data as quantitative measures of past North Pacific climate variability. Annual accumulation at Logan is poorly correlated with Gulf of Alaska sea level pressure (SLP), but well correlated with Pacific sea surface temperature (SST) anomalies. The latter correlation forms a horseshoe pattern of warmer than average SSTs in the eastern North Pacific around colder than average SSTs in the central Pacific similar to the dominant EOF of SSTs (the Pacific Decadal Oscillation). Back-trajectory calculations show that most air reaching Mt. Logan follows a high-altitude pathway along the upper limb of the horseshoe pattern from the western Pacific. However, further analyses suggest that the moisture source changes according to the strength of the Aleutian Low. Mean SSTs are highest along the west coast of North America and lowest in the central North Pacific and Japan during years when the Aleutian Low is strong. During weak Aleutian Low years, accumulation is most highly correlated with SSTs around Japan and the Philippines (r ~ 0.5), while when the Aleutian Low is strong, it is most highly correlated with SSTs along the west coast of North America and the northern most part of the Pacific (r ~ 0.7). Finally, \\delta18O ratios at Mt. Logan are negatively correlated with sea level pressure (SLP) anomalies in the Gulf of Alaska (r ~ -0.4). Together, these results suggest that during years in which the Aleutian Low is weak, the west and central Pacific are the moisture sources for Mt. Logan while advection of local moisture dominates precipitation when the Aleutian Low is strong.

  2. New geophysical views of Mt.Melbourne Volcano (East Antarctica)

    NASA Astrophysics Data System (ADS)

    Armadillo, E.; Gambetta, M.; Ferraccioli, F.; Corr, H.; Bozzo, E.

    2009-05-01

    Mt. Melbourne volcano is located along the transition between the Transantarctic Mountains and the West Antarctic Rift System. Recent volcanic activity is suggested by the occurrence of blankets of pyroclastic pumice and scoria fall around the eastern and southern flanks of Mt Melbourne and by pyroclastic layers interbedded with the summit snows. Geothermal activity in the crater area of Mount Melbourne may be linked to the intrusion of dykes within the last 200 years. Geophysical networks suggest that Mount Melbourne is a quiescent volcano, possibly characterised by slow internal dynamics. During the 2002-2003 Italian Antarctic campaign a high-resolution aeromagnetic survey was performed within the TIMM (Tectonics and Interior of Mt. Melbourne area) project. This helicopter-borne survey was flown at low-altitude and in drape-mode configuration (305 m above terrain) with a line separation less than 500 m. Our new high-resolution magnetic maps reveal the largely ice-covered magmatic and tectonic patters in the Mt. Melbourne volcano area. Additionally, in the frame of the UK-Italian ISODYN-WISE project (2005-06), an airborne ice-sounding radar survey was flown. We combine the sub-ice topography with images and models of the interior of Mt. Melbourne volcano, as derived from the high resolution aeromagnetic data and land gravity data. Our new geophysical maps and models also provide a new tool to study the regional setting of the volcano. In particular we re-assess whether there is geophysical evidence for coupling between strike-slip faulting, the Terror Rift, and Mount Melbourne volcano.

  3. Ramelteon, a selective MT1/MT2 receptor agonist, suppresses the proliferation and invasiveness of endometrial cancer cells.

    PubMed

    Osanai, Kiyono; Kobayashi, Yoichi; Otsu, Masahiro; Izawa, Tomoko; Sakai, Keiji; Iwashita, Mitsutoshi

    2017-07-01

    The incidence of endometrial cancer is increasing, making it the fifth most common cancer worldwide. To date, however, there is no standard therapy for patients with recurrent endometrial cancer. Melatonin, a hormone secreted by the pineal gland, has been shown to have anti-tumor effects in various tumor types. Although melatonin is available as a supplement, it has not been approved for cancer treatment. Ramelteon, a selective melatonin receptor type 1 and 2 (MT1/MT2) receptor agonist, has been approved to treat sleep disorders, suggesting that ramelteon may be effective in the treatment of endometrial cancer. To determine whether this agent may be effective in the treatment of endometrial cancer, this study investigated the ability of ramelteon to suppress the proliferation and invasiveness of HHUA cells, an estrogen receptor-positive endometrial cancer cell line. Ramelteon at 10(-8) M maximally suppressed the proliferation of HHUA cells, reducing the percentage of Ki-67 positive proliferating cells. This effect was completely blocked by luzindole, a MT1/MT2 receptor antagonist. Furthermore, ramelteon inhibited HHUA cell invasion and reduced the expression of the MMP-2 and MMP-9 genes. These results suggested that ramelteon may be a candidate for the treatment of recurrent endometrial cancer, with activity similar to that of melatonin.

  4. Decay spectroscopy of element 115 daughters: Rg280→Mt276 and Mt276→Bh272

    DOE PAGES

    Gates, J. M.; Gregorich, K. E.; Gothe, O. R.; ...

    2015-08-03

    In this study, forty-six decay chains, assigned to the decay of 288115, were produced using the 243Am (48Ca, 3n) 288115 reaction at the Lawrence Berkeley National Laboratory 88-in. cyclotron. The resulting series of α decays were studied using α-photon and α-x-ray spectroscopies. Multiple α-photon coincidences were observed in the element 115 decay chain members, particularly in the third- and fourth-generation decays (presumed to be 280Rg and 276Mt, respectively). Upon combining these data with those from 22 288115 decay chains observed in a similar experiment, updated level schemes in 276Mt and 272Bh (populated by the α decay of 280Rg and 276Mt,more » respectively) are proposed. Additionally, photons were observed in the energy range expected for K x rays coincident with the α decay of both 280Rg and 276Mt. However, Compton scattering of higher-energy γ rays and discrete transitions are present in the K x-ray region preventing a definitive Z identification to be made based on observation of characteristic K x-ray energies.« less

  5. Analysis of BRCA1 and mtDNA haplotypes and mtDNA polymorphism in familial breast cancer.

    PubMed

    Gutiérrez Povedano, Cristina; Salgado, Josefa; Gil, Carmen; Robles, Maitane; Patiño-García, Ana; García-Foncillas, Jesús

    2015-04-01

    Mitochondrial DNA (mtDNA) defects have been postulated to play an important role in the modulation and/or progression of cancer. In the past decade, a wide spectrum of mtDNA variations have been suggested as potentially sensitive and specific biomarkers for several human cancer types. In this context, single nucleotide polymorphisms (SNPs) described as protective or risk variants have been published, in particular in breast cancer, though not without controversy. Moreover, many mtDNA haplogroups have been associated with different phenotypes and diseases. We genotyped 18 SNPs, 15 of them defining European mtDNA haplogroups, including SNPs described as protective or risk variants, 7 SNPs that determine BRCA1 haplotypes and a BRCA1 intron 7 polymorphism. We included in this study 90 Caucasian unrelated women with breast cancer with familial criteria and 96 controls. Our aim was to clarify the importance of any of these SNPs, mitochondrial haplogroups and BRCA1 haplotypes in the modulation of breast cancer. We detected no significant differences in the distribution of BRCA1 haplotypes between patients and controls. Haplogroup U and the 12308G variant of mtDNA were overrepresented within the control group (p = 0.005 and p = 0.036, respectively) compared to breast cancer. Finally, we identified a significant association between the BRCA1 intron 7 polymorphism and BRCA1 haplotypes. Specifically, (TTC)6/6 and (TTC)6/7 genotypes with the seven polymorphic site cassette of "H2-like" haplotypes, and the (TTC)7/7 genotype associated with the "H1-like" haplotypes (p < 0.001).

  6. Barley Metallothioneins: MT3 and MT4 Are Localized in the Grain Aleurone Layer and Show Differential Zinc Binding1[W][OA

    PubMed Central

    Hegelund, Josefine Nymark; Schiller, Michaela; Kichey, Thomas; Hansen, Thomas Hesselhøj; Pedas, Pai; Husted, Søren; Schjoerring, Jan Kofod

    2012-01-01

    Metallothioneins (MTs) are low-molecular-weight, cysteine-rich proteins believed to play a role in cytosolic zinc (Zn) and copper (Cu) homeostasis. However, evidence for the functional properties of MTs has been hampered by methodological problems in the isolation and characterization of the proteins. Here, we document that barley (Hordeum vulgare) MT3 and MT4 proteins exist in planta and that they differ in tissue localization as well as in metal coordination chemistry. Combined transcriptional and histological analyses showed temporal and spatial correlations between transcript levels and protein abundance during grain development. MT3 was present in tissues of both maternal and filial origin throughout grain filling. In contrast, MT4 was confined to the embryo and aleurone layer, where it appeared during tissue specialization and remained until maturity. Using state-of-the-art speciation analysis by size-exclusion chromatography inductively coupled plasma mass spectrometry and electrospray ionization time-of-flight mass spectrometry on recombinant MT3 and MT4, their specificity and capacity for metal ion binding were quantified, showing a strong preferential Zn binding relative to Cu and cadmium (Cd) in MT4, which was not the case for MT3. When complementary DNAs from barley MTs were expressed in Cu- or Cd-sensitive yeast mutants, MT3 provided a much stronger complementation than did MT4. We conclude that MT3 may play a housekeeping role in metal homeostasis, while MT4 may function in Zn storage in developing and mature grains. The localization of MT4 and its discrimination against Cd make it an ideal candidate for future biofortification strategies directed toward increasing food and feed Zn concentrations. PMID:22582132

  7. Weak Lensing Calibrated M-T Scaling Relation of Galaxy Groups in the COSMOS Fieldsstarf

    NASA Astrophysics Data System (ADS)

    Kettula, K.; Finoguenov, A.; Massey, R.; Rhodes, J.; Hoekstra, H.; Taylor, J. E.; Spinelli, P. F.; Tanaka, M.; Ilbert, O.; Capak, P.; McCracken, H. J.; Koekemoer, A.

    2013-11-01

    The scaling between X-ray observables and mass for galaxy clusters and groups is instrumental for cluster-based cosmology and an important probe for the thermodynamics of the intracluster gas. We calibrate a scaling relation between the weak lensing mass and X-ray spectroscopic temperature for 10 galaxy groups in the COSMOS field, combined with 55 higher-mass clusters from the literature. The COSMOS data includes Hubble Space Telescope imaging and redshift measurements of 46 source galaxies per arcminute2, enabling us to perform unique weak lensing measurements of low-mass systems. Our sample extends the mass range of the lensing calibrated M-T relation an order of magnitude lower than any previous study, resulting in a power-law slope of 1.48^{+0.13}_{-0.09}. The slope is consistent with the self-similar model, predictions from simulations, and observations of clusters. However, X-ray observations relying on mass measurements derived under the assumption of hydrostatic equilibrium have indicated that masses at group scales are lower than expected. Both simulations and observations suggest that hydrostatic mass measurements can be biased low. Our external weak lensing masses provide the first observational support for hydrostatic mass bias at group level, showing an increasing bias with decreasing temperature and reaching a level of 30%-50% at 1 keV. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by AURA Inc., under NASA contract NAS 5-26555. Also based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan; the XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA; the European Southern Observatory under Large Program 175.A-0839, Chile; Kitt Peak National Observatory, Cerro Tololo Inter-American Observatory, and the National Optical Astronomy Observatory, which

  8. Legume Resources: MtDB and Medicago.Org.

    PubMed

    Retzel, Ernest F; Johnson, James E; Crow, John A; Lamblin, Anne F; Paule, Charles E

    2007-01-01

    To identify the genes and gene functions that underlie key aspects of legume biology, researchers have selected the cool season legume Medicago truncatula as a model system for legume research. The mission of the M. truncatula Consortium is to promote unrestricted sharing of data and information that are provided by Medicago research groups worldwide. Through integration of a variety of data and tools, the medicago.org site intends to facilitate progress in the fields of structural, comparative, and functional genomics. To this goal, and as a consortium partner, the Center for Computational Genomics and Bioinformatics (CCGB) at the University of Minnesota has developed MtDB2.0, the M. truncatula database version 2.0. The MtDB2.0 database is the first step toward the global integration of M. truncatula genomic, genetic, and biological information. MtDB2.0 is a relational database that integrates M. truncatula transcriptome data and provides a wide range of user-defined data mining options. The database is interrogated through a series of interfaces, with 58 options grouped into two filters. Sequence identifiers from all public M. truncatula sites [e.g., IDs from GenBank, CCGB, The Institute for Genomic Research (TIGR), National Center for Genome Resources (NCGR), and I'Institut National de la Recherche Agronomique (INRA)] are fully cross-referenced to facilitate comparisons between different sites, and hypertext links to the appropriate database records are provided for all queries' results. MtDB's goal is to provide researchers with the means to quickly and independently identify sequences that match specific research interests based on user-defined criteria. MtDB2.0 offers unrestricted access to advanced and powerful querying tools unmatched by any other public databases. Structurad Query Language (SQL)-encoded queries with a Java-based Web user interface, incorporate different filtering that allow sophisticated data mining of the expressed sequence tag sequencing

  9. Snow Depth Depicted on Mt. Lyell by NASA Airborne Snow Observatory

    NASA Image and Video Library

    2013-05-02

    A natural color image of Mt. Lyell, the highest point in the Tuolumne River Basin top image is compared with a three-dimensional color composite image of Mt. Lyell from NASA Airborne Snow Observatory depicting snow depth bottom image.

  10. 78 FR 38821 - Airworthiness Directives; Eurocopter France Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... new airworthiness directive (AD) for Eurocopter France Model EC 155B, EC155B1, SA-366G1, SA-365N, SA... apply to Eurocopter France Model EC 155B, EC155B1, SA-366G1, SA-365N, SA-365N1, AS-365N2, and AS 365 N3..., 2011 (AD No. 2011-0190), to correct an unsafe condition for the Eurocopter France EC 155, SA 366,...

  11. Human tularemia in France, 2006-2010.

    PubMed

    Maurin, Max; Pelloux, Isabelle; Brion, Jean Paul; Del Banõ, Jeanne-Noëlle; Picard, Aleth

    2011-11-01

    Tularemia is an endemic but rare disease in France. We describe the epidemiologic, clinical, diagnostic, treatment, and prognostic aspects of the disease in 101 consecutive patients investigated during a 5-year period (2006-2010). All tularemia cases confirmed at the French Reference Center for Tularemia (FRCT) were included. Data were collected both at the Institut de Veille Sanitaire (mandatory notification) and FRCT. Diagnostic methods included serological tests (microagglutination and indirect immunofluorescence assay), Francisella tularensis cultures, real-time polymerase chain reaction (RT-PCR) tests, and molecular identification of the F. tularensis subspecies involved. The patient cohort consisted of 55 men and 46 women (sex ratio, 1.2; average age, 51.7 years), including 93 sporadic cases that occurred throughout France. Contaminations occurred predominantly through contact with or ingestion of lagomorphs (31.7%), tick bites (10.9%), or contaminated environments (7.9%). The glandular and ulceroglandular forms predominated (57.5% of cases), but 18.8% of patients experienced a systemic disease and 29.7% were hospitalized. Specific diagnosis was mainly based on serology, but 38.6% of patients had positive RT-PCR tests and 20.8% had a positive culture. F. tularensis subspecies holarctica was identified in 25 patients. All patients except 1 recovered from infection, but 38.6% experienced relapses despite appropriate antibiotic therapy. The epidemiological and clinical aspects of tularemia in France are varied, suggesting different modes of contamination. The high rates of systemic diseases and hospitalization indicate that the more serious cases are more likely to be diagnosed and notified. RT-PCR tests may help to improve diagnosis and reporting of the disease.

  12. [Epidemiology of induced abortion in France].

    PubMed

    Vigoureux, S

    2016-12-01

    Conduct a synthesis of existing knowledge about the frequency of induced abortion or termination of pregnancy and unplanned pregnancies, the exposure factors of unplanned pregnancies and abortion and the associated morbidity and mortality. Consultation of The Medline database, and national and international reports on abortions in France and in developed countries. Voluntary termination of pregnancy is an induced abortion, opted for non-medical reasons, which in France can be performed before 14 weeks of gestation. Abortion is a common procedure, with rare complications, amounting to about 220,000 procedures per year in France with a stable rate over decades. Similarly to births, women aged 20 to 24 are most affected. The possibility of an abortion exists for all women; this potential event, however, is not equal for each and varies by age of women, socio-professional situations, geographical origins, marital status and past or present domestic and sexual violence. The French historical analysis shows that for 50 years the increase in contraceptive prevalence rate is associated with a decrease in the frequency of unplanned pregnancies. It is therefore possible that the prevention of unplanned pregnancy through early uptake of contraception and contraception options by women is related to a woman's lifestyle. Nonetheless, the number of abortion remains stable since its decriminalization despite the large increase in medicalized contraceptive prevalence rate. Good knowledge of the epidemiology of voluntary termination of pregnancy and unplanned pregnancies is a prerequisite to better adopt prevention and case management strategies. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  13. [Current data on malaria in metropolitan France].

    PubMed

    Danis, M; Legros, F; Thellier, M; Caumes, E

    2002-01-01

    Epidemiological data from the French National Reference Center for Imported Diseases showed that the estimated number of cases of imported malaria in France increased from 5,940 in 1998 to 7,127 in 1999 and 8,056 in 2000. This three-year progression ended in 2001 when the number of estimated cases fell back to 7,223. It was due mainly to the concomitant increase in the number of people traveling to endemic zones especially in Africa. In 2000 the median age of patients with imported malaria in France was 29.5 years and the sex ratio was 1.78. Sixty-three percent of cases involved people of African origin and 37% involved "Westerners". The countries in which contamination occurred were located in tropical Africa (95%), Asia (2.2%), and Latin America (2.7%). During the three year period from 1998 to 2000, there were a total of 13 accidental autochtonous cases of malaria involving patients with no history of travel to tropical areas. The distribution of Plasmodium species involved in imported malaria in France was stable with 83% of cases involving Plasmodium falciparum, 6% involving Plasmodium vivax, 6.5% involving Plasmodium ovale and 1.3% involving Plasmodium malariae. Attacks were clinically uncomplicated in 90 to 95% of cases and severe in 2 to 5% including fatal Plasmodium falciparum malaria in 0.49 to 0.37% of cases. Less than 10% of the 45% of patients claiming use of prophylaxis complied properly. Analysis of the drugs used for curative treatment in 2000 showed an increase in the use of quinine and mefloquine and decrease in the use of halofantrine. The main objectives remain reduction of mortality and improvement of prevention.

  14. Outlier detection for groundwater data in France

    NASA Astrophysics Data System (ADS)

    Valmy, Larissa; de Fouquet, Chantal; Bourgine, Bernard

    2014-05-01

    Quality and quantity water in France are increasingly observed since the 70s. Moreover, in 2000, the EU Water Framework Directive established a framework for community action in the water policy field for the protection of inland surface waters (rivers and lakes), transitional waters (estuaries), coastal waters and groundwater. It will ensure that all aquatic ecosystems and, with regard to their water needs, terrestrial ecosystems and wetlands meet 'good status' by 2015. The Directive requires Member States to establish river basin districts and for each of these a river basin management plan. In France, monitoring programs for the water status were implemented in each basin since 2007. The data collected through these programs feed into an information system which contributes to check the compliance of water environmental legislation implementation, assess the status of water guide management actions (programs of measures) and evaluate their effectiveness, and inform the public. Our work consists in study quality and quantity groundwater data for some basins in France. We propose a specific mathematical approach in order to detect outliers and study trends in time series. In statistic, an outlier is an observation that lies outside the overall pattern of a distribution. Usually, the presence of an outlier indicates some sort of problem, thus, it is important to detect it in order to know the cause. In fact, techniques for temporal data analysis have been developed for several decades in parallel with geostatistical methods. However compared to standard statistical methods, geostatistical analysis allows incomplete or irregular time series analysis. Otherwise, tests carried out by the BRGM showed the potential contribution of geostatistical methods for characterization of environmental data time series. Our approach is to exploit this potential through the development of specific algorithms, tests and validation of methods. We will introduce and explain our method

  15. [Infant botulism in France, 1991-2009].

    PubMed

    King, L-A; Popoff, M-R; Mazuet, C; Espié, E; Vaillant, V; de Valk, H

    2010-09-01

    Infant botulism is caused by the ingestion of spores of Clostridium botulinum and affects newborns and infants under 12 months of age. Ingested spores multiply and produce botulinum toxin in the digestive tract, which then induces clinical symptoms. A single French case was described in the literature prior to 1991. We describe the cases of infant botulism identified in France between 1991 and 2009. All clinical suspicions of botulism must be declared in France. Biological confirmation of the disease is provided by the National reference laboratory for anaerobic bacteria and botulism at the Pasteur Institute. During this period, 7 cases of infant botulism were identified, 1 per year from 2004 to 2008 and 2 in 2009. The median age of affected infants was 119 days and all were female. All infants presented with constipation and oculomotor symptoms. All were hospitalized and required mechanical ventilation. The infants recovered from their botulism. The diagnosis of infant botulism was biologically confirmed for all patients. One 4-month-old infant was treated with a single dose of the human-derived botulism antitoxin specific for infant botulism types A and B (BabyBIG®). The infants all had different feeding habits ranging from exclusive breast feeding to a mix of formula feeding and solid food consumption. The consumption of honey, the only documented risk food for this disease, was reported for 3 of the infants. The honey had been placed on the pacifier of 2 infants and directly in the mouth of the 3rd by the mother. Infant botulism, a form of botulism that was previously rarely recognized in France, has been reported more frequently during the last 6 years. This disease remains rare but nonetheless severe. In light of recent epidemiological data, efforts to raise awareness among parents of infants and health professionals on the danger of infant botulism and particularly, its association with honey consumption seems necessary.

  16. How Gaz de France optimizes LNG regasification

    SciTech Connect

    Colonna, J.L.; Lecomte, B.; Caudron, S.

    1986-05-05

    A regasification optimization program was implemented at Montoir-de-Bretagne in 1984, and rapidly accepted by the operators. It has been an important tool for decision-making in the optimizing operation of this liquefied natural gas (LNG) storage and regasification terminal. The models used are regularly and easily updated on the basis of equipment behavior: aging or fouling. The Montoir-de-Bretagne LNG terminal is in the port area of Nates-Saint Nazaire on the Atlantic coast. It was commissioned in 1982 by Gaz de France. This terminal is used for receiving, storing, and regasifying the Algerian LNG received under a contract between Gaz de France and Sonatrach, as well as the LNG imported by Belgium and temporarily routed through France. It is designed to receive 25,000 to 200,000 cu m LNG carriers and has three 120,000 cm m LNG storage tanks. The daily sendout ranges between 6.7 million cu m and 36 million cu m. Monitor terminal supplies mainly Brittany and the Paris area. Two identifical berths allow the simultaneous reception of two LNG carriers. LNG is carried to the storage tanks in 32-in. lines at a rate of 12,000 cu m/hr. Each storage tank is equipped with three submerged 450 cu m/hr pumps with which the LNG is sent from the tanks to the secondary pumps at 8 bar. The nine high-pressure (HP) secondary pumps, with a capacity of either 450 cu m/hr or 180 cu m/hr, raise the LNG pressure to a level at least equal to pipeline pressure prior to revaporization.

  17. New melatonin (MT1/MT2) ligands: design and synthesis of (8,9-dihydro-7H-furo[3,2-f]chromen-1-yl) derivatives.

    PubMed

    Landagaray, Elodie; Ettaoussi, Mohamed; Leclerc, Véronique; Traoré, Balla; Perez, Valérie; Nosjean, Olivier; Boutin, Jean A; Caignard, Daniel-Henri; Delagrange, Philippe; Berthelot, Pascal; Yous, Saïd

    2014-02-01

    Herein we describe the synthesis of novel tricyclic analogues issued from the rigidification of the methoxy group of the benzofuranic analogue of melatonin as MT1 and MT2 ligands. Most of the synthesized compounds displayed high binding affinities at MT1 and MT2 receptors subtypes. Compound 6b (MT1, Ki=0.07nM; MT2, Ki=0.08nM) exhibited with the vinyl 6c and allyl 6d the most interesting derivatives of this series. Functional activity of these compounds showed full agonist activity with EC50 in the nanomolar range. Compounds 6a (EC50=0.8nM and Emax=98%) and 6b (EC50=0.2nM and Emax=121%) exhibited good pharmacological profiles. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Mt. Wilson Meets the Lyot Double Image Micrometer

    NASA Astrophysics Data System (ADS)

    Weise, Eric; Genet, Russell; Buchheim, Bob; Gelston, Ryan; Brewer, Mark; Genet, Cheryl; Gerhart, Christine; Wallen, Vera

    2015-07-01

    As part of the Mt. Wilson Double Star Workshop, the authors used a double image micrometer to observe two double stars, STF2383CD and STF2583AB, on the night of July 19, 2013 (B2013.547). The instrument was designed in 1949 by Bernard Lyot and built by Meca-Precis. We found separations of 2.53±0.29'' for STF2383CD and 1.58±0.40'' for STF2583AB, and positions angles of 77.8±2.3° for STF 2383CD and 103.4±1.6° for STF2583AB. The scarcity of double image micrometers and the opportunity to use the historic 60 inch telescope at Mt Wilson made this workshop a very unique experience.

  19. Microtron MT 25 as a source of neutrons

    SciTech Connect

    Kralik, M.; Solc, J.; Chvatil, D.; Krist, P.; Turek, K.; Granja, C.

    2012-08-15

    The objective was to describe Microtron MT25 as a source of neutrons generated by bremsstrahlung induced photonuclear reactions in U and Pb targets. Bremsstrahlung photons were produced by electrons accelerated at energy 21.6 MeV. Spectral fluence of the generated neutrons was calculated with MCNPX code and then experimentally determined at two positions by means of a Bonner spheres spectrometer in which the detector of thermal neutrons was replaced by activation Mn tablets or track detectors CR-39 with a {sup 10}B radiator. The measured neutron spectral fluence and the calculated anisotropy served for the estimation of neutron yield from the targets and for the determination of ambient dose equivalent rate at the place of measurement. Microtron MT25 is intended as one of the sources for testing neutron sensitive devices which will be sent into the space.

  20. A portable ELF-MT system for shallow resistivity sounding

    NASA Astrophysics Data System (ADS)

    Fujii, T.; Komori, H.; Honkura, Y.

    1989-03-01

    In view of recent extensive investigation of shallow resistivity structure for active fault studies and geothermal exploration, we developed a portable magnetotelluric (MT) system for the extremely low frequency (ELF) range. The system aims primarily at making real-time analyses of MT data at the so-called Schumann resonance frequencies of ˜ 8, 14 and 20 Hz. Calculations of the apparent resistivity, the phase, etc. are made by a small HC-20 computer, which also controls data acquisition. We made performance tests of this system and compared the results with those derived by the conventional method using the large computer at our computer center. The stacking number of 30 for Fourier transform stacking turned out to be sufficient to obtain results comparable with those by the conventional method. The time required for this processing is ˜ 15 min. This system can also be used for continuous monitoring of time-dependence of shallow crustal resistivity, particularly for earthquake prediction studies.

  1. Mt. Etna, Sicily as seen from STS-64

    NASA Image and Video Library

    1994-09-19

    STS064-71-037 (9-20 Sept. 1994) --- Mt. Etna on Sicily displays a steam plume from its summit. Geologists attribute the volcano's existence to the collision of tectonic plates. Unlike the sudden, explosive eruption at Rabaul, Mt. Etna's activity is ongoing and is generally not explosive - Etna's slopes have been settled with villages and cultivated land for centuries. Other Mediterranean volcanoes (like Santorini) have experienced large catastrophic eruptions. Etna recently finished a two-year eruption (ending in 1993), marked by relatively gentle lava flows down the eastern flank. It has been continually degassing since then, according to the geologists, producing an omnipresent steam plume, as seen here. The 1993 flow is difficult to identify in this image because it lies within shadows on the eastern flank, but small cinder cones on the western flank mark earlier episodes of volcanic activity. Photo credit: NASA or National Aeronautics and Space Administration

  2. Attention to surfaces modulates motion processing in extrastriate area MT.

    PubMed

    Wannig, Aurel; Rodríguez, Valia; Freiwald, Winrich A

    2007-05-24

    In the visual system, early atomized representations are grouped into higher-level entities through processes of perceptual organization. Here we present neurophysiological evidence that a representation of a simple object, a surface defined by color and motion, can be the unit of attentional selection at an early stage of visual processing. Monkeys were cued by the color of a fixation spot to attend to one of two transparent random-dot surfaces, one red and one green, which occupied the same region of space. Motion of the attended surface drove neurons in the middle temporal (MT) visual area more strongly than physically identical motion of the non-attended surface, even though both occurred within the spotlight of attention. Surface-based effects of attention persisted even without differential surface coloring, but attentional modulation was stronger with color. These results show that attention can select surface representations to modulate visual processing as early as cortical area MT.

  3. MT Serpentis: A pre-cataclysmic variable or not?

    NASA Astrophysics Data System (ADS)

    Bruch, A.

    2002-01-01

    MT Ser, the central star of the planetary nebula Abell 41, shows photometric variations with a period of P1 = 2h 43m (Grauer & Bond 1983, ApJ, 271, 259). They are interpreted as due to a reflection effect in a close binary consisting of a compact hot component and a cool star (Model 1). This configuration would make MT Ser the pre-cataclysmic variable with the shortest known orbital period. However, an alternative scenario of a system consisting of two hot subdwarfs in an orbit with period P2 = 2 P1 is also possible (Model 2). The light curve can then be explained by ellipsoidal variations and (partial) eclipses.

  4. Neural Representation of Motion-In-Depth in Area MT

    PubMed Central

    Sanada, Takahisa M.

    2014-01-01

    Neural processing of 2D visual motion has been studied extensively, but relatively little is known about how visual cortical neurons represent visual motion trajectories that include a component toward or away from the observer (motion in depth). Psychophysical studies have demonstrated that humans perceive motion in depth based on both changes in binocular disparity over time (CD cue) and interocular velocity differences (IOVD cue). However, evidence for neurons that represent motion in depth has been limited, especially in primates, and it is unknown whether such neurons make use of CD or IOVD cues. We show that approximately one-half of neurons in macaque area MT are selective for the direction of motion in depth, and that this selectivity is driven primarily by IOVD cues, with a small contribution from the CD cue. Our results establish that area MT, a central hub of the primate visual motion processing system, contains a 3D representation of visual motion. PMID:25411481

  5. Model of the 2003 Tour de France

    NASA Astrophysics Data System (ADS)

    Hannas, Benjamin Lee; Goff, John Eric

    2004-05-01

    We modeled the 2003 Tour de France bicycle race using stage profile data for which elevations at various points in each stage are known. Each stage is modeled as a series of inclined planes. We accounted for the forces on a bicycle-rider combination such as aerodynamic drag and rolling resistance and calculated the winning stage times for an assumed set of bicycle and rider parameters. The calculated total race time differed from the sum of all actual winning stage times by only 0.03%.

  6. [National organization of forensic medicine in France].

    PubMed

    Chariot, Patrick

    2012-06-01

    Forensic medicine has long been characterized, in France, by diverse medical practices, which affected its recognition and development. A change was needed, Harmonization procedure includes the development of professional guidelines and allows forensic medicine to look at itself. However, the implementation of the recommendations is still far from complete. A national reform came into effect on 15 January 2011 and has defined a national reform of forensic medicine which includes funding by global budgets instead of fee-for-service. This reform allows easier organization and identification of forensic medicine units. One year later, tangible results are mixed. Forensic medicine is now more clearly identified but properly defined funding criteria are still lacking.

  7. France: Thrust and parry over nuclear risks

    SciTech Connect

    Balter, M.

    1997-01-31

    Claims about the health risks posed by nuclear-power installations are always controversial, but nowhere more so than in France, where some 75% of the nation`s electricity is generated from nuclear energy. So, it was no surprise that publication of a study by two French epidemiologists earlier this month claiming to show a link between cases of childhood leukemia and the nuclear-waste reprocessing plant at La Hague on the Normandy coast sparked fireworks in the French press. Several French epidemiologists sharply criticized the study`s methodology and conclusions. Their attacks have now drawn an unusual response from the British Medical Journal (BMJ), in which the paper appeared.

  8. [Economic repercussions of cardiac insufficiency in France].

    PubMed

    Selke, B; Brunot, A; Lebrun, T

    2003-03-01

    The aim of the article is to review economic and public health consequences of congestive heart failure in France. This disease with an increasing prevalence induces for the social security system and the society a high cost; 85 to 93% of this cost are bound to hospitalizations, most of them avoidable. New modalities of care are to be chosen in order to improve the management of heart failure and to contain costs. In this context, multidisciplinary interventions based on patients' education are experimented taking care to assure a greater role to health actors working in the ambulatory sector (GPs, private cardiologists, nurses).

  9. Frances E. Jensen's The Teenage Brain.

    PubMed

    Silveri, Marisa M

    2015-01-01

    The unpredictable and sometimes incomprehensible moods and behaviors of a teenager can be a head-scratching mystery-especially to parents. Hormones, boredom, social media, peer pressure, and drugs and alcohol are just a few of the factors to consider. Frances E. Jensen, M.D., professor and chair of neurology at the University of Pennsylvania and the mother of two sons who are now in their twenties (along with Washington Post health and science reporter and Pulitzer Prize winner Amy Ellis Nutt) look at the emerging science of the adolescent brain and provide advice based on Jensen's own research and experience as a single mother.

  10. Directions toward the Year 2000. Strategic Plan, Mt. San Antonio Community College.

    ERIC Educational Resources Information Center

    Mount San Antonio Community Coll. District, Walnut, CA.

    This booklet presents Mt. San Antonio College's (Mt. SAC's) long-range goals and specific action priorities in an effort to focus planning on the year 2000. Introductory comments discuss the purpose of strategic planning and Mt. SAC's planning orientation. The next sections list goals and objectives with respect to: (1) the improvement of existing…

  11. 77 FR 41939 - Proposed Establishment of Class E Airspace; Deer Lodge, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-17

    ... Proposed Establishment of Class E Airspace; Deer Lodge, MT AGENCY: Federal Aviation Administration (FAA... airspace at Deer Lodge-City-County Airport, Deer Lodge, MT. Controlled airspace is necessary to accommodate... procedures at Deer Lodge-City-County Airport, Deer Lodge, MT. The FAA is proposing this action to enhance...

  12. 77 FR 39651 - Proposed Establishment of Class E Airspace; Circle Town, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... County Airport, Circle Town, MT, to accommodate aircraft using new Area Navigation (RNAV) Global... aircraft using new RNAV (GPS) standard instrument approach procedures at Circle Town County Airport. This.... * * * * * ANM MT E5 Circle Town, MT [New] Circle Town County Airport (Lat. 47[deg]25'06'' N., long. 105[deg]33...

  13. Random Genetic Drift Determines the Level of Mutant mtDNA in Human Primary Oocytes

    PubMed Central

    Brown, D. T.; Samuels, D. C.; Michael, E. M.; Turnbull, D. M.; Chinnery, P. F.

    2001-01-01

    We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes. PMID:11133360

  14. 78 FR 52112 - Proposed Amendment of Class E Airspace; Cut Bank, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-22

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Cut Bank, MT AGENCY... action proposes to modify Class E airspace at Cut Bank Municipal Airport, Cut Bank, MT. Controlled... from 700/1,200 feet above the surface at Cut Bank Municipal Airport, Cut Bank, MT. Controlled airspace...

  15. 78 FR 54415 - Proposed Establishment of Class E Airspace; Ennis, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ...). SUMMARY: This action proposes to establish Class E airspace at Ennis- Big Sky Airport, Ennis, MT... System (GPS) standard instrument approach procedures at Ennis-Big Sky Airport, Ennis, MT. The FAA is... from 700 feet above the surface within a 7-mile radius of Ennis- Big Sky Airport, Ennis, MT, along...

  16. Directions toward the Year 2000. Strategic Plan, Mt. San Antonio Community College.

    ERIC Educational Resources Information Center

    Mount San Antonio Community Coll. District, Walnut, CA.

    This booklet presents Mt. San Antonio College's (Mt. SAC's) long-range goals and specific action priorities in an effort to focus planning on the year 2000. Introductory comments discuss the purpose of strategic planning and Mt. SAC's planning orientation. The next sections list goals and objectives with respect to: (1) the improvement of existing…

  17. Contrahelicase activity of the mitochondrial transcription termination factor mtDBP

    PubMed Central

    Polosa, Paola Loguercio; Deceglie, Stefania; Roberti, Marina; Gadaleta, Maria Nicola; Cantatore, Palmiro

    2005-01-01

    The sea urchin mitochondrial D-loop binding protein (mtDBP) is a transcription termination factor that is able to arrest bidirectionally mitochondrial RNA chain elongation. The observation that the mtDBP binding site in the main non-coding region is located in correspondence of the 3′ end of the triplex structure, where the synthesis of heavy strand mitochondrial (mt) DNA is either prematurely terminated or allowed to continue, raised the question whether mtDBP could also regulate mtDNA replication. By using a helicase assay in the presence of the replicative helicase of SV40, we show that mtDBP is able to inhibit the enzyme thus acting as a contrahelicase. The impairing activity of mtDBP is bidirectional as it is independent of the orientation of the protein binding site. The inhibition is increased by the presence of the guanosine-rich sequence that flanks mtDBP binding site. Finally, a mechanism of abrogation of mtDBP contrahelicase activity is suggested that is based on the dissociation of mtDBP from DNA caused by the passage of the RNA polymerase through the protein–DNA complex. All these findings favour the view that mtDBP, besides serving as transcription termination factor, could also act as a negative regulator of mtDNA synthesis at the level of D-loop expansion. PMID:16006625

  18. 77 FR 43183 - Proposed Modification of Class E Airspace; Wolf Point, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ...-ANM-17 Proposed Modification of Class E Airspace; Wolf Point, MT AGENCY: Federal Aviation... Class E airspace at Wolf Point, MT. Controlled airspace is necessary to accommodate aircraft using Nondirectional Radio Beacon (NDB) standard instrument approach procedures at L M Clayton Airport, Wolf Point, MT...

  19. 77 FR 64714 - Modification of Class E Airspace; Wolf Point, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Federal Aviation Administration 14 CFR Part 71 Modification of Class E Airspace; Wolf Point, MT AGENCY... airspace at Wolf Point, MT. Controlled airspace is necessary to accommodate aircraft using Nondirectional Radio Beacon (NDB) standard instrument approach procedures at L M Clayton Airport, Wolf Point, MT. This...

  20. An Analysis of the Mt. Meron Seismic Array

    SciTech Connect

    Pasyanos, M E; Ryall, F

    2008-01-10

    We have performed a quick analysis of the Mt. Meron seismic array to monitor regional seismic events in the Middle East. The Meron array is the only current array in the Levant and Arabian Peninsula and, as such, might be useful in contributing to event location, identification, and other analysis. Here, we provide a brief description of the array and a review of the travel time and array analysis done to assess its performance.

  1. Vertical Scales of Turbulence at the Mt. Wilson Observatory

    NASA Technical Reports Server (NTRS)

    Treuhaft, Robert N.

    1995-01-01

    The vertical scales of turbulence at the Mt. Wilson observatory are inferred from data from the University of California at Berkeley Infrared Spatial Interferometer (ISI), by modeling path length fluctuations observed in the interferometric paths to celestial objects and those in instrumental ground- based paths. The correlations between the stellar and ground-based path length fluctuations and the temporal statistic of those fluctuations are modeled on various time scales to constrain the vertical scales.

  2. MT-Toolbox: improved amplicon sequencing using molecule tags.

    PubMed

    Yourstone, Scott M; Lundberg, Derek S; Dangl, Jeffery L; Jones, Corbin D

    2014-08-22

    Short oligonucleotides can be used as markers to tag and track DNA sequences. For example, barcoding techniques (i.e. Multiplex Identifiers or Indexing) use short oligonucleotides to distinguish between reads from different DNA samples pooled for high-throughput sequencing. A similar technique called molecule tagging uses the same principles but is applied to individual DNA template molecules. Each template molecule is tagged with a unique oligonucleotide prior to polymerase chain reaction. The resulting amplicon sequences can be traced back to their original templates by their oligonucleotide tag. Consensus building from sequences sharing the same tag enables inference of original template molecules thereby reducing effects of sequencing error and polymerase chain reaction bias. Several independent groups have developed similar protocols for molecule tagging; however, user-friendly software for build consensus sequences from molecule tagged reads is not readily available or is highly specific for a particular protocol. MT-Toolbox recognizes oligonucleotide tags in amplicons and infers the correct template sequence. On a set of molecule tagged test reads, MT-Toolbox generates sequences having on average 0.00047 errors per base. MT-Toolbox includes a graphical user interface, command line interface, and options for speed and accuracy maximization. It can be run in serial on a standard personal computer or in parallel on a Load Sharing Facility based cluster system. An optional plugin provides features for common 16S metagenome profiling analysis such as chimera filtering, building operational taxonomic units, contaminant removal, and taxonomy assignments. MT-Toolbox provides an accessible, user-friendly environment for analysis of molecule tagged reads thereby reducing technical errors and polymerase chain reaction bias. These improvements reduce noise and allow for greater precision in single amplicon sequencing experiments.

  3. Vertical Scales of Turbulence at the Mt. Wilson Observatory

    NASA Technical Reports Server (NTRS)

    Treuhaft, Robert N.

    1995-01-01

    The vertical scales of turbulence at the Mt. Wilson observatory are inferred from data from the University of California at Berkeley Infrared Spatial Interferometer (ISI), by modeling path length fluctuations observed in the interferometric paths to celestial objects and those in instrumental ground- based paths. The correlations between the stellar and ground-based path length fluctuations and the temporal statistic of those fluctuations are modeled on various time scales to constrain the vertical scales.

  4. Volcanogenic origin of cenotes near Mt Gambier, southeastern Australia

    NASA Astrophysics Data System (ADS)

    Webb, John A.; Grimes, Ken G.; Lewis, Ian D.

    2010-07-01

    The cenotes near Mt Gambier are circular, cliffed, collapse dolines containing water-table lakes up to 125 m deep, floored by large rubble cones. They lie in a flat, coastal plain composed of mid-Tertiary limestone. Most of the deepest cenotes are concentrated in two small areas located along trends sub-parallel to the main joint direction in the limestone. The cenotes do not connect to underwater phreatic passages, and water chemistry data confirm that they are not part of an interconnected karst network. They formed by collapse into large chambers (up to > 1 million m 3) that extended 125 m or more below the land surface. Several cenotes have actively growing stromatolites on the sub-vertical walls that started growing at ˜ 8000 years BP. The caves that collapsed to form the deep Mt Gambier cenotes are much larger than shallow and deep phreatic caves in the area, and do not connect into deep phreatic systems. They were not formed by freshwater/seawater mixing, responsible for many of the well-known Yucatan cenotes, because they are not associated with locations of the mixing zone during previous high sea levels, and are much larger than caves presently forming along the mixing zone near Mt Gambier. Instead dissolution was most likely due to a process whereby acidified groundwater containing large amounts of volcanogenic CO 2 ascended up fractures from the magma chambers that fed the Pleistocene-Holocene volcanic eruptions in the area; deep reservoirs of volcanogenic CO 2 occur nearby. Cave dissolution could have been due to release of CO 2 during the Mt Gambier eruption ˜ 28,000 years ago, followed by collapse to form cenotes during the low sea levels of the Last Glacial Maximum ˜ 20,000 years ago. The cenotes then flooded ˜ 8000 years ago as sea level rose, and stromatolites began to grow on the walls.

  5. Into thin air: extreme ultrasound on Mt Everest.

    PubMed

    Otto, Christian; Hamilton, Douglas R; Levine, Benjamin D; Hare, Craig; Sargsyan, Ashot E; Altshuler, Peter; Dulchavsky, Scott A

    2009-01-01

    Mountaineers face a variety of health risks at altitude including pulmonary edema; portable ultrasound may be used to diagnose high altitude pulmonary edema. This report tests the functionality of electronic equipment in a hypobaric test environment and the ability of remotely guided nonexperts to use ultrasound to evaluate respiratory status on Mt Everest. Two ultrasound devices and associated video equipment were tested in a cooled (4 degrees C-5 degrees C) hypobaric chamber to 27000 feet (8230 m) before travel to Mt Everest. The ultrasound system was connected via satellite phone to a video streaming device and portable computer to stream video through the Internet for remote guidance of a novice user by an expert. Pulmonary interstitial fluid was quantified by the presence of "comet tail" artifacts. There was no notable degradation in equipment performance in cold, hypobaric conditions; ultrasound confirmation of increased comet tails was noted in the chamber despite oxygen supplementation and the very brief exposure. Two pulmonary surveys of asymptomatic participants were completed by novice operators within 25 minutes on Mt Everest. The remote expert was able to guide and identify comet tails suggestive of intermediate pulmonary interstitial fluid. Image quality was excellent. The tested ultrasound devices functioned nominally in cold, hypobaric conditions; acute changes in lung fluid content were noted in these conditions despite normoxia. We successfully used a satellite telemedical connection with a remote expert to guide thoracic ultrasound examinations at Advanced Base Camp on Mt Everest. Coupling portable ultrasound with remote expert guidance telemedicine provides a robust diagnostic capability in austere locations.

  6. miRNAs in mtDNA-less cell mitochondria

    PubMed Central

    Dasgupta, N; Peng, Y; Tan, Z; Ciraolo, G; Wang, D; Li, R

    2015-01-01

    The novel regulation mechanism in mtDNA-less cells was investigated. Very low mtDNA copy in mtDNA-less 206 ρ° cells was identified. But no 13 mitochondria-specific proteins were translated in 206 ρ° cells. Their mitochondrial respiration complexes V, III and II were 86.5, 29.4 and 49.6% of 143B cells, respectively. Complexes I and IV completely lack in 206 ρ° cells. Non-mitochondrial respiration to generate ATP in 206 ρ° cells was discovered. The expression levels of some mitochondrial RNAs including 12S rRNA, COX1, COX2, COX3, ND4 and ND5 were low. However, ND1, ND3 and Cyto b were not expressed in 206 ρ° cells. Unequal transcription of mitochondrial RNAs indicated the post-transcriptional cleavage and processing mechanisms in the regulation of mitochondrial gene expression in 206 ρ° cells. MicroRNAs (miRNAs) may modulate these mitochondrial RNA expression in these cells. RNA-induced silencing complex indeed within 206 ρ° cell mitochondria indicated miRNAs in 206 ρ° cell mitochondria. miRNA profile in mtDNA-less 206 ρ° cells was studied by next-generation sequencing of small RNAs. Several mitochondria-enriched miRNAs such as miR-181c-5p and miR-146a-5p were identified in 206 ρ° cell mitochondria. miR-181c-5p and miR-146a-5p had 23 and 19 potential targets on mitochondrial RNAs respectively, and these two miRNAs had multiple targets on mitochondria-associated messenger RNAs encoded by nuclear genes. These data provided the first direct evidence that miRNAs were imported into mitochondria and regulated mitochondrial RNA expressions. PMID:27551440

  7. La France a ta porte: Negocier les apprentissages (France at Your Doorstep: Negotiating Learning Experiences).

    ERIC Educational Resources Information Center

    de Acosta, Asuncion; Serna, Isabel

    1992-01-01

    A second-language teaching strategy in which students are active in the selection of a unit theme and objective is discussed. In this approach, the teacher assumes the role of monitor in student development of the unit. A sample unit on language for daily living in France illustrates the process. (MSE)

  8. Geothermal energy resource investigations at Mt. Spurr, Alaska

    SciTech Connect

    Turner, D.L.; Wescott, E.M.

    1986-12-01

    Spurr volcano is a composite Quaternary cone of largely andesitic composition located on the west side of Cook Inlet about 80 miles west of Anchorage and about 40 miles from the Beluga electrical transmission line. Geologic mapping (Plate 1-1) shows that the present summit depression was produced by a Mt. St. Helens-type sector collapse, rather than by a caldera collapse. Geochronologic and previous tephrachronologic studies show that there has been an active magmatic system at Spurr volcano during the late Pleistocene-to-Holocene time interval that is of critical interest for geothermal energy resource assessment. Major effort was devoted to geochemical and geophysical surveys of the accessible area south of Mt. Spurr, in addition to geologic mapping and geochronologic studies. Many coincident mercury and helium anomalies were found, suggesting the presence of geothermal systems at depth. Extremely large electrical self-potential anomalies were also found, together with extensive zones of low resistivity discovered by our controlled-source audiomagnetotelluric survey. The juxtaposition of all of these different types of anomalies at certain areas on the south slope of Crater Peak indicates the presence of a geothermal system which should be accessible by drilling to about 2000 ft depth. It is also evident that there is a strong volcanic hazard to be evaluated in considering any development on the south side of Mt. Spurr. This hazardous situation may require angle drilling of production wells from safer areas and placement of power generation facilities at a considerable distance from hazardous areas.

  9. Study on new optimum parameters in MT repeated survey

    NASA Astrophysics Data System (ADS)

    Zhang, Yun-Lin; Liu, Xiao-Ling; An, Hai-Jing; Jiang, Mei; Li, Zhi-Xiong; Si, Yu-Lan; Zhang, Wu-Si

    1994-11-01

    The first MT monitoring profile with initial shape both at home and abroad has been built in the northern margin of the Qinghai-Tibet Plateau. Based on MT data observed before and after the eight earthquakes of M=5 7 from 1988 to 1992, a new parameter-mean resistivitybar ρ has been introduced. The results show thatbar ρ indicates not only the major feature of decreasing-increasing and recovering to normal value, but also synchronism of phase or the variation in a large area, “lead or delay” among different small areas and the amplitude decreasing with the increase of the distance from the epicenter. Two characters mentioned above might correspond to reginal field precursor of the tectonic generating earthquake and field precursor of the tectonic kinematics. This paper analyses the errors of observed data and the cause of ρ variation. The MT profile optimum parameter system consists of parameterbar ρ , apparent resistivity ρ, twisting degree and the principal-axis azimuth which might provide quantitative criterion for the physical proces of the great destructive earthquake and moderate and short-term earthquake prediction.

  10. Evidences for higher nocturnal seismic activity at the Mt. Vesuvius

    NASA Astrophysics Data System (ADS)

    Mazzarella, Adriano; Scafetta, Nicola

    2016-07-01

    We analyze hourly seismic data measured at the Osservatorio Vesuviano Ovest (OVO, 1972-2014) and at the Bunker Est (BKE, 1999-2014) stations on the Mt. Vesuvius. The OVO record is complete for seismic events with magnitude M ≥ 1.9. We demonstrate that before 1996 this record presents a daily oscillation that nearly vanishes afterwards. To determine whether a daily oscillation exists in the seismic activity of the Mt. Vesuvius, we use the higher quality BKE record that is complete for seismic events with magnitude M ≥ 0.2. We demonstrate that BKE confirms that the seismic activity at the Mt. Vesuvius is higher during nighttime than during daytime. The amplitude of the daily oscillation is enhanced during summer and damped during winter. We speculate possible links with the cooling/warming diurnal cycle of the volcanic edifice, with external geomagnetic field and with magnetostriction, which stress the rocks. We find that the amplitude of the seismic daily cycle changes in time and has been increasing since 2008. Finally, we propose a seismic activity index to monitor the 24-hour oscillation that could be used to complement other methodologies currently adopted to determine the seismic status of the volcano to prevent the relative hazard.

  11. Seismo Gravity Observations of Mt. Bromo, East Java, Indonesia

    NASA Astrophysics Data System (ADS)

    Maryanto, S.

    2016-12-01

    Mt. Bromo, an active quaternary volcanoes located at Tengger caldera, Probolinggo, East Java. The magma chamber of Mt. Bromo had been studied by using the intergrated method of gravity and seismic. Gravity method studied subsurface density contrast variation in 2D model. Meanwhile, seismic method studied magma chamber geometry based on hypocenter distribution of A-type volcanic earthquake (VTA) signals. 2D gravity model showed that the magma chamber exists at 2 km up to 12.5 km under mean sea level and dominated by andesitic magmas (ρ=2.66 g/cm3). Besides, quantitative interpretation of Bromo subsurface also indicates that this area is formed by quartzite and granite formations. Based on the hypocenter distribution, shown that two magma chambers estimated beneath Bromo volcano. The shallow magma chamber located at 2 km up to 5 km depth under the summit of Bromo volcano. Meanwhile, the deep magma chamber located on 7 km up to 15 km of depth under the summit of Mt. Bromo.

  12. CD44 regulates pancreatic cancer invasion through MT1-MMP.

    PubMed

    Jiang, Wei; Zhang, Yaqing; Kane, Kevin T; Collins, Meredith A; Simeone, Diane M; di Magliano, Marina Pasca; Nguyen, Kevin Tri

    2015-01-01

    Pancreatic cancer is one of the deadliest human malignancies due to its early metastatic spread and resistance to therapy. The mechanisms regulating pancreatic cancer metastasis are so far poorly understood. Here, using both in vitro and in vivo approaches, it is demonstrated that CD44, a transmembrane glycoprotein expressed on a subset of pancreatic cancer cells, is required for the induction of epithelial-mesenchymal transition (EMT) and the activation of an invasive program in pancreatic cancer. Mechanistically, the transcription factor Snail1 (SNAI1), a regulator of the EMT program, is a downstream target of CD44 in primary pancreatic cancer cells and regulates membrane bound metalloproteinase (MMP14/MT1-MMP) expression. In turn, MT1-MMP expression is required for pancreatic cancer invasion. Thus, these data establish the CD44-Snail-MMP axis as a key regulator of the EMT program and of invasion in pancreatic cancer. This study sets the stage for CD44 and MT1-MMP as therapeutic targets in pancreatic cancer, for which small molecule or biologic inhibitors are available. Visual Overview: http://mcr.aacrjournals.org/content/early/2014/09/10/1541-7786.MCR-14-0076/F1.large.jpg. ©2014 American Association for Cancer Research.

  13. CD44 regulates pancreatic cancer invasion through MT1-MMP

    PubMed Central

    Jiang, Wei; Zhang, Yaqing; Kane, Kevin T.; Collins, Meredith A.; Simeone, Diane M.; di Magliano, Marina Pasca; Nguyen, Kevin Tri

    2014-01-01

    Pancreatic cancer is one of the deadliest human malignancies due to its early metastatic spread and resistance to therapy. The mechanisms regulating pancreatic cancer metastasis are so far poorly understood. Here, using both in vitro and in vivo approaches, it is demonstrated that CD44, a transmembrane glycoprotein expressed on a subset of pancreatic cancer cells, is required for the induction of epithelial-mesenchymal transition (EMT) and the activation of an invasive program in pancreatic cancer. Mechanistically, the transcription factor Snail1 (SNAI1), a regulator of the EMT program, is a downstream target of CD44 in primary pancreatic cancer cells and regulates membrane bound metalloproteinase (MMP14/MT1-MMP) expression. In turn, MT1-MMP expression is required for pancreatic cancer invasion. Thus, these data establish the CD44-Snail-MMP axis as a key regulator of the EMT program and of invasion in pancreatic cancer. (135) IMPLICATIONS This study sets the stage for CD44 and MT1-MMP as therapeutic targets in pancreatic cancer, for which small molecule or biologic inhibitors are available. PMID:25566991

  14. The making of the African mtDNA landscape.

    PubMed

    Salas, Antonio; Richards, Martin; De la Fe, Tomás; Lareu, María-Victoria; Sobrino, Beatriz; Sánchez-Diz, Paula; Macaulay, Vincent; Carracedo, Angel

    2002-11-01

    Africa presents the most complex genetic picture of any continent, with a time depth for mitochondrial DNA (mtDNA) lineages >100,000 years. The most recent widespread demographic shift within the continent was most probably the Bantu dispersals, which archaeological and linguistic evidence suggest originated in West Africa 3,000-4,000 years ago, spreading both east and south. Here, we have carried out a thorough phylogeographic analysis of mtDNA variation in a total of 2,847 samples from throughout the continent, including 307 new sequences from southeast African Bantu speakers. The results suggest that the southeast Bantu speakers have a composite origin on the maternal line of descent, with approximately 44% of lineages deriving from West Africa, approximately 21% from either West or Central Africa, approximately 30% from East Africa, and approximately 5% from southern African Khoisan-speaking groups. The ages of the major founder types of both West and East African origin are consistent with the likely timing of Bantu dispersals, with those from the west somewhat predating those from the east. Despite this composite picture, the southeastern African Bantu groups are indistinguishable from each other with respect to their mtDNA, suggesting that they either had a common origin at the point of entry into southeastern Africa or have undergone very extensive gene flow since.

  15. The Making of the African mtDNA Landscape

    PubMed Central

    Salas, Antonio; Richards, Martin; De la Fe, Tomás; Lareu, María-Victoria; Sobrino, Beatriz; Sánchez-Diz, Paula; Macaulay, Vincent; Carracedo, Ángel

    2002-01-01

    Africa presents the most complex genetic picture of any continent, with a time depth for mitochondrial DNA (mtDNA) lineages >100,000 years. The most recent widespread demographic shift within the continent was most probably the Bantu dispersals, which archaeological and linguistic evidence suggest originated in West Africa 3,000–4,000 years ago, spreading both east and south. Here, we have carried out a thorough phylogeographic analysis of mtDNA variation in a total of 2,847 samples from throughout the continent, including 307 new sequences from southeast African Bantu speakers. The results suggest that the southeast Bantu speakers have a composite origin on the maternal line of descent, with ∼44% of lineages deriving from West Africa, ∼21% from either West or Central Africa, ∼30% from East Africa, and ∼5% from southern African Khoisan-speaking groups. The ages of the major founder types of both West and East African origin are consistent with the likely timing of Bantu dispersals, with those from the west somewhat predating those from the east. Despite this composite picture, the southeastern African Bantu groups are indistinguishable from each other with respect to their mtDNA, suggesting that they either had a common origin at the point of entry into southeastern Africa or have undergone very extensive gene flow since. PMID:12395296

  16. 75 FR 43556 - TA-W-73,381, MT Rail Link, Inc., Missoula, MT; TA-W-73,381A, Billings, MT; TA-W-73,381B, Laurel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... Employment and Training Administration TA-W-73,381, MT Rail Link, Inc., Missoula, MT; TA-W-73,381A, Billings... facilities (yards) in Billings, Laurel, Livingston, Helena and Missoula, Montana. The Billings, Laurel... Rail Link, Inc. at facilities in Billings, Laurel, Livingston, and Helena, Montana. The amended...

  17. Causes and Consequences of Rapidly Evolving mtDNA in a Plant Lineage

    PubMed Central

    Trapp, Paul; Miller, Christopher M.; Bazos, Ioannis

    2017-01-01

    Understanding mechanisms of coevolution between nuclear and mitochondrial (mt) genomes is a defining challenge in eukaryotic genetics. The angiosperm genus Silene is a natural system to investigate the causes and consequences of mt mutation rate variation because closely related species have highly divergent rates. In Silene species with fast-evolving mtDNA, nuclear genes that encode mitochondrially targeted proteins (N-mt genes) are also fast-evolving. This correlation could indicate positive selection to compensate for mt mutations, but might also result from a recent relaxation of selection. To differentiate between these interpretations, we used phylogenetic and population-genetic methods to test for positive and relaxed selection in three classes of N-mt genes (oxidative phosphorylation genes, ribosomal genes, and “RRR” genes involved in mtDNA recombination, replication, and repair). In all three classes, we found that species with fast-evolving mtDNA had: 1) elevated dN/dS, 2) an excess of nonsynonymous divergence relative to levels of intraspecific polymorphism, which is a signature of positive selection, and 3) no clear signals of relaxed selection. “Control” genes exhibited comparatively few signs of positive selection. These results suggest that high mt mutation rates can create selection on N-mt genes and that relaxed selection is an unlikely cause of recent accelerations in the evolution of N-mt genes. Because mt-RRR genes were found to be under positive selection, it is unlikely that elevated mt mutation rates in Silene were caused by inactivation of these mt-RRR genes. Therefore, the causes of extreme increases in angiosperm mt mutation rates remain uncertain. PMID:28164243

  18. Adjusting MtDNA Quantification in Whole Blood for Peripheral Blood Platelet and Leukocyte Counts.

    PubMed

    Hurtado-Roca, Yamilee; Ledesma, Marta; Gonzalez-Lazaro, Monica; Moreno-Loshuertos, Raquel; Fernandez-Silva, Patricio; Enriquez, Jose Antonio; Laclaustra, Martin

    2016-01-01

    Alterations of mitochondrial DNA copy number (mtDNAcn) in the blood (mitochondrial to nuclear DNA ratio) appear associated with several systemic diseases, including primary mitochondrial disorders, carcinogenesis, and hematologic diseases. Measuring mtDNAcn in DNA extracted from whole blood (WB) instead of from peripheral blood mononuclear cells or buffy coat may yield different results due to mitochondrial DNA present in platelets. The aim of this work is to quantify the contribution of platelets to mtDNAcn in whole blood [mtDNAcn(WB)] and to propose a correction formula to estimate leukocytes' mtDNAcn [mtDNAcn(L)] from mtDNAcn(WB). Blood samples from 10 healthy adults were combined with platelet-enriched plasma and saline solution to produce artificial blood preparations. Aliquots of each sample were combined with five different platelet concentrations. In 46 of these blood preparations, mtDNAcn was measured by qPCR. MtDNAcn(WB) increased 1.07 (95%CI 0.86, 1.29; p<0.001) per 1000 platelets present in the preparation. We proved that leukocyte count should also be taken into account as mtDNAcn(WB) was inversely associated with leukocyte count; it increased 1.10 (95%CI 0.95, 1.25, p<0.001) per unit increase of the ratio between platelet and leukocyte counts. If hematological measurements are available, subtracting 1.10 the platelets/leukocyte ratio from mtDNAcn(WB) may serve as an estimation for mtDNAcn(L). Both platelet and leukocyte counts in the sample are important sources of variation if comparing mtDNAcn among groups of patients when mtDNAcn is measured in DNA extracted from whole blood. Not taking the platelet/leukocyte ratio into account in whole blood measurements, may lead to overestimation and misclassification if interpreted as leukocytes' mtDNAcn.

  19. Adjusting MtDNA Quantification in Whole Blood for Peripheral Blood Platelet and Leukocyte Counts

    PubMed Central

    Gonzalez-Lazaro, Monica; Moreno-Loshuertos, Raquel; Fernandez-Silva, Patricio; Enriquez, Jose Antonio; Laclaustra, Martin

    2016-01-01

    Alterations of mitochondrial DNA copy number (mtDNAcn) in the blood (mitochondrial to nuclear DNA ratio) appear associated with several systemic diseases, including primary mitochondrial disorders, carcinogenesis, and hematologic diseases. Measuring mtDNAcn in DNA extracted from whole blood (WB) instead of from peripheral blood mononuclear cells or buffy coat may yield different results due to mitochondrial DNA present in platelets. The aim of this work is to quantify the contribution of platelets to mtDNAcn in whole blood [mtDNAcn(WB)] and to propose a correction formula to estimate leukocytes' mtDNAcn [mtDNAcn(L)] from mtDNAcn(WB). Blood samples from 10 healthy adults were combined with platelet-enriched plasma and saline solution to produce artificial blood preparations. Aliquots of each sample were combined with five different platelet concentrations. In 46 of these blood preparations, mtDNAcn was measured by qPCR. MtDNAcn(WB) increased 1.07 (95%CI 0.86, 1.29; p<0.001) per 1000 platelets present in the preparation. We proved that leukocyte count should also be taken into account as mtDNAcn(WB) was inversely associated with leukocyte count; it increased 1.10 (95%CI 0.95, 1.25, p<0.001) per unit increase of the ratio between platelet and leukocyte counts. If hematological measurements are available, subtracting 1.10 the platelets/leukocyte ratio from mtDNAcn(WB) may serve as an estimation for mtDNAcn(L). Both platelet and leukocyte counts in the sample are important sources of variation if comparing mtDNAcn among groups of patients when mtDNAcn is measured in DNA extracted from whole blood. Not taking the platelet/leukocyte ratio into account in whole blood measurements, may lead to overestimation and misclassification if interpreted as leukocytes' mtDNAcn. PMID:27736919

  20. Overview of manure treatment in France.

    PubMed

    Loyon, L

    2017-03-01

    Manure treatment becomes a focal issue in relation to current EU and national policies on environmental, climate and renewable energy matters. The objective of this desk study was to collect all available data on the treatment of manure from cattle, pig and poultry farms for an overview of manure treatment in France. Specific surveys in 2008 showed that 12% of pig farms, 11% of poultry farms and 7.5% of cattle farms was concerned by manure treatment. Taken together, the treatment of pig, poultry and cattle manure accounted for 13.6milliontons corresponding to 11.3% of the total annual tonnage (120milliontons). The main processes, mostly applied on the farm, were composting (8.5milliontons), aerobic treatment (2.9milliontons of pig slurry) and anaerobic digestion (1milliontons). Other manure treatments, including physical-chemical treatment, were less frequent (0.4million of m(3)). Treated manure was mainly used to fertilize the soil and crops on the farm concerned. Manure treatment can thus be considered to be underused in France. However, anaerobic digestion is expected to expand to reach the European target of 20% of energy from renewable sources. Nevertheless, this expansion will depend on overcoming the constraint requiring registration or normalization of the use of the digestate as fertilizer. Thus, to avoid penalizing farmers, the further development or creation of collective processing platforms is recommended, combined with an N recovery process that will enable the production of organic amendments and fertilizers in an easy marketable form.

  1. Medication Sales and Syndromic Surveillance, France

    PubMed Central

    Grais, Rebecca F.; Sarter, Hélène; Fagot, Jean-Paul; Lambert, Bruno; Valleron, Alain-Jacques; Flahault, Antoine

    2006-01-01

    Although syndromic surveillance systems using nonclinical data have been implemented in the United States, the approach has yet to be tested in France. We present the results of the first model based on drug sales that detects the onset of influenza season and forecasts its trend. Using weekly lagged sales of a selected set of medications, we forecast influenzalike illness (ILI) incidence at the national and regional level for 3 epidemic seasons (2000-01, 2001-02, and 2002-03) and validate the model with real-time updating on the fourth (2003-04). For national forecasts 1–3 weeks ahead, the correlation between observed ILI incidence and forecast was 0.85–0.96, an improvement over the current surveillance method in France. Our findings indicate that drug sales are a useful additional tool to syndromic surveillance, a complementary and independent source of information, and a potential improvement for early warning systems for both epidemic and pandemic planning. PMID:16704778

  2. Aedes albopictus: a potential problem in France.

    PubMed

    Rodhain, F

    1995-12-01

    Aedes albopictus, a mosquito of Asian origin, has been rapidly spreading in all the continents since a decade: it is now established in North and South America, Africa, Oceania and even in Europe where it was detected in Albania, 1979 and in Italy, 1990. The international shipping trade of used tires provides to Ae. albopictus an ideal mechanism of dissemination, and everywhere the tire stocks constitute an extremely productive ecological niche. Now, this mosquito is present in several localities in Northern and Central Italy, and it is a real threat for other Mediterranean countries, particularly Southern part of France (French Riviera and Corsica) where climatic conditions are very suitable for its establishment. In addition, the tolerance exhibited by some natural populations of Ae. albopictus for low temperatures allows this species to occupy an area much further north than Ae. aegypti. Ae. albopictus is a very competent vector for many arboviruses, particularly the four dengue serotypes, with the possibility of a vertical transmission; we also know that it can act as an experimental vector for many other viruses. The consequences of its introduction into France would lie in an increased level of transmission of autochthonous viral or filarial (canine dirofilariasis) infections, along with the spread of viruses presently unknown in the region (like dengue, Rift Valley fever, Batai, etc.). For these reasons, it is necessary to set up a permanent entomological surveillance in all the threatened areas in order to detect immediately such an introduction and to be able to quickly eliminate the mosquito.

  3. Strategic nuclear forces of Britain and France

    SciTech Connect

    Prados, J.; Wit, J.S.; Zagurek, M.J. Jr.

    1984-08-01

    Weapon inventories of the US and the USSR account for about 97% of the nuclear warheads in the world today; Britain and France have most of the remainder. Yet even the comparatively modest claims the two Western European nations can make in this regard represent an awesome military capability that the USSR (and, to a lesser extent, the US) cannot afford to ignore. Indeed, the recent proposals both superpowers have made to dismantle all their European-based intermediate-range missiles differ sharply in particulars but raise the same fundamental question: What role will the other nuclear forces in Europe have in the future military balance. The Europeans are unlikely to place their limited strategic forces on the bargaining table along with those of the USSR and the US unless the superpowers impose severe constraints on their own strategic-weapon programs, and in particular on their strategic-defense programs. The deployment of such defense systems poses a worrisome dilemma for the Europeans: while in the near term a Soviet anti-ballistic-missile (ABM) system might have only marginal military impact, over the longer term a novel, exotic defense could conceivably nullify the dependent deterrent Britain and France have so arduously sought. At the same time and American system such as the Strategic Defense Initiative could, by decoupling the defense of Europe from that of the US, increase the need for precisely such an independent deterrent in the minds of the British and the French.

  4. Processes Controlling Spessartite Generation beneath Mt. Rainier, Washington

    NASA Astrophysics Data System (ADS)

    Bohrson, W. A.; Scott, S. R.

    2008-12-01

    Mt. Rainier is a composite volcano located in the Cascade volcanic arc about 60km SE of Tacoma, Washington (Crowley et at., 1997). The volcanism at Mt. Rainier is a consequence of subduction of the Juan de Fuca plate under the North American plate at an average rate of 50mmyr-1 (Lowrie, 2007). Based on a compilation of data representing basaltic andesites through dacites (Sisson & Vallance, submitted, Sisson, personal communication) 125 MELTS (Ghiorso & Sack, 1995) models have been run to constrain the mechanisms of formation for the typical liquid line of descent. Using a variety of parental magmas, models were run through pressure space of 1-10 kbars, with initial water contents from 1-5 wt. %, and with fO2 buffers of QFM or NNO. The best fit model for the Mt. Rainier rocks involves crystallization at 1-1.5 kbars from a melt with an initial H2O content of 3.5 wt. % and oxygen fugacity of QFM. Comparing the best fit MELTS models with the suite of associated rocks from Mt. Rainier provides evidence for fractional crystallization and magma mixing as the dominant processes, consistent with the work of Sisson & Hankins (2007). While most Mt. Rainier lavas typically contain phenocrysts of plagioclase and pyroxene, one particular lava flow classified as a spessartite andesite possesses phenocrysts of amphibole and pyroxene. The spessartite also has a high concentration of K2O relative to typical andesites and is enriched in LREEs and LILEs. Fractional and equilibrium crystallization MELTS models have not successfully reproduced the trends exhibited by the spessartite, suggesting that the magma evolved by processes different than simple crystallization; MELTS modeling of more complex petrogenetic scenarios is currently underway. Electron microprobe data of amphibole and pyroxene from the spessartite demonstrate a complex history of crystal growth as well. The amphiboles range in composition from ~2 to 15 wt. % Al2O3 and ~6 to 12 wt. % FeO*. Pyroxene phenocrysts have Mg

  5. Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies.

    PubMed

    Leger, Damien; Quera-Salva, Maria-Antonia; Vecchierini, Marie-Françoise; Ogrizek, Pascale; Perry, Christina A; Dressman, Marlene A

    2015-01-01

    Tasimelteon, a novel circadian regulator, is the first product for the treatment of Non-24-hour Sleep-Wake Disorder (Non-24) approved by either the FDA or the European Medicines Agency (EMA). Tasimelteon is a potent and specific melatonin (MT1 and MT2) receptor agonist with 2 - 4 times greater affinity for the MT2 receptor. Safety was assessed in two controlled and two open-label studies in blind individuals with Non-24 and in two controlled studies of primary insomnia. Periodic assessments included collection of adverse events (AEs), laboratory testing, electrocardiograms (ECGs), vital sign monitoring, physical examinations and assessment for the potential for suicide. One study included additional assessments for endocrine function. A total of 184 blind individuals with Non-24 received tasimelteon nightly with a median exposure > 1 year. In placebo-controlled studies, 387 patients with insomnia and 42 patients with Non-24 received tasimelteon nightly for 4 - 26 weeks. The total patient years exposure for the six studies assessed here is 258.64 patient years. Discontinuations due to AEs were similar across treatment groups. Overall in the clinical studies described here, AEs attributable to tasimelteon treatment were headache, diarrhea, dry mouth, alanine aminotransferase increased, somnolence, dizziness and nightmare/abnormal dreams. There were no clinically significant differences in treatment group with ECGs, vital signs, withdrawal, endocrine function and suicidality assessments. Long-term tasimelteon administration was safe and well-tolerated. This is supported by placebo-controlled data in both Non-24 and insomnia patients.

  6. Evidence for a Fourteenth mtDNA-Encoded Protein in the Female-Transmitted mtDNA of Marine Mussels (Bivalvia: Mytilidae)

    PubMed Central

    Breton, Sophie; Ghiselli, Fabrizio; Passamonti, Marco; Milani, Liliana; Stewart, Donald T.; Hoeh, Walter R.

    2011-01-01

    Background A novel feature for animal mitochondrial genomes has been recently established: i.e., the presence of additional, lineage-specific, mtDNA-encoded proteins with functional significance. This feature has been observed in freshwater mussels with doubly uniparental inheritance of mtDNA (DUI). The latter unique system of mtDNA transmission, which also exists in some marine mussels and marine clams, is characterized by one mt genome inherited from the female parent (F mtDNA) and one mt genome inherited from the male parent (M mtDNA). In freshwater mussels, the novel mtDNA-encoded proteins have been shown to be mt genome-specific (i.e., one novel protein for F genomes and one novel protein for M genomes). It has been hypothesized that these novel, F- and M-specific, mtDNA-encoded proteins (and/or other F- and/or M-specific mtDNA sequences) could be responsible for the different modes of mtDNA transmission in bivalves but this remains to be demonstrated. Methodology/Principal Findings We investigated all complete (or nearly complete) female- and male-transmitted marine mussel mtDNAs previously sequenced for the presence of ORFs that could have functional importance in these bivalves. Our results confirm the presence of a novel F genome-specific mt ORF, of significant length (>100aa) and located in the control region, that most likely has functional significance in marine mussels. The identification of this ORF in five Mytilus species suggests that it has been maintained in the mytilid lineage (subfamily Mytilinae) for ∼13 million years. Furthermore, this ORF likely has a homologue in the F mt genome of Musculista senhousia, a DUI-containing mytilid species in the subfamily Crenellinae. We present evidence supporting the functionality of this F-specific ORF at the transcriptional, amino acid and nucleotide levels. Conclusions/Significance Our results offer support for the hypothesis that “novel F genome-specific mitochondrial genes” are involved in key

  7. Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) Modulates Water Homeostasis in Mice

    PubMed Central

    Srichai, Manakan B.; Colleta, Heloisa; Gewin, Leslie; Matrisian, Linsey; Abel, Ty W.; Koshikawa, Naohiko; Seiki, Motoharu; Pozzi, Ambra; Harris, Raymond C.; Zent, Roy

    2011-01-01

    MT4-MMP is a membrane-type metalloproteinase (MMP) anchored to the membrane by a glycosyl-phosphatidylinositol (GPI) motif. GPI-type MT-MMPs (MT4- and MT6-MMP) are related to other MT-MMPs, but their physiological substrates and functions in vivo have yet to be identified. In this manuscript we show that MT4-MMP is expressed early in kidney development, as well as in the adult kidney, where the highest levels of expression are found in the papilla. MT4-MMP null mice had minimal renal developmental abnormalities, with a minor branching morphogenesis defect in early embryonic kidney development and slightly dysmorphic collecting ducts in adult mice. Interestingly, MT4-MMP null mice had higher baseline urine osmolarities relative to wild type controls, but these animals were able to concentrate and dilute their urines normally. However, MT4-MMP-null mice had decreased daily water intake and daily urine output, consistent with primary hypodipsia. MT4-MMP was shown to be expressed in areas of the hypothalamus considered important for regulating thirst. Thus, our results show that although MT4-MMP is expressed in the kidney, this metalloproteinase does not play a major role in renal development or function; however it does appear to modify the neural stimuli that modulate thirst. PMID:21347258

  8. Simplified qPCR method for detecting excessive mtDNA damage induced by exogenous factors.

    PubMed

    Gureev, Artem P; Shaforostova, Ekaterina A; Starkov, Anatoly A; Popov, Vasily N

    2017-05-01

    Damage to mitochondrial DNA (mtDNA) is a meaningful biomarker for evaluating genotoxicity of drugs and environmental toxins. Existing PCR methods utilize long mtDNA fragments (∼8-10kb), which complicates detecting exact sites of mtDNA damage. To identify the mtDNA regions most susceptible to damage, we have developed and validated a set of primers to amplify ∼2kb long fragments, while covering over 95% of mouse mtDNA. We have modified the detection method by greatly increasing the enrichment of mtDNA, which allows us solving the problem of non-specific primer annealing to nuclear DNA. To validate our approach, we have determined the most damage-susceptible mtDNA regions in mice treated in vivo and in vitro with rotenone and H2O2. The GTGR-sequence-enriched mtDNA segments located in the D-loop region were found to be especially susceptible to damage. Further, we demonstrate that H2O2-induced mtDNA damage facilitates the relaxation of mtDNA supercoiled conformation, making the sequences with minimal damage more accessible to DNA polymerase, which, in turn, results in a decrease in threshold cycle value. Overall, our modified PCR method is simpler and more selective to the specific sites of damage in mtDNA. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. An enhanced MITOMAP with a global mtDNA mutational phylogeny

    PubMed Central

    Ruiz-Pesini, Eduardo; Lott, Marie T.; Procaccio, Vincent; Poole, Jason C.; Brandon, Marty C.; Mishmar, Dan; Yi, Christina; Kreuziger, James; Baldi, Pierre; Wallace, Douglas C.

    2007-01-01

    The MITOMAP () data system for the human mitochondrial genome has been greatly enhanced by the addition of a navigable mutational mitochondrial DNA (mtDNA) phylogenetic tree of ∼3000 mtDNA coding region sequences plus expanded pathogenic mutation tables and a nuclear-mtDNA pseudogene (NUMT) data base. The phylogeny reconstructs the entire mutational history of the human mtDNA, thus defining the mtDNA haplogroups and differentiating ancient from recent mtDNA mutations. Pathogenic mutations are classified by both genotype and phenotype, and the NUMT sequences permits detection of spurious inclusion of pseudogene variants during mutation analysis. These additions position MITOMAP for the implementation of our automated mtDNA sequence analysis system, Mitomaster. PMID:17178747

  10. Repetitive transcranial magnetic stimulation of human MT+ reduces apparent motion perception.

    PubMed

    Matsuyoshi, Daisuke; Hirose, Nobuyuki; Mima, Tatsuya; Fukuyama, Hidenao; Osaka, Naoyuki

    2007-12-18

    We investigated the effects of repetitive transcranial magnetic stimulation (rTMS) over the human cerebral cortex on apparent motion perception. Previous studies have shown that human extrastriate visual area MT+ (V5) processes not only real but also apparent motion. However, the functional relevance of MT+ on long-range apparent motion perception remains unclear. Here, we show direct evidence for the involvement of MT+ in apparent motion perception using rTMS, which is known to temporarily inhibit a localized region in the cerebral cortex. The results showed that apparent motion perception decreased after applying rTMS over MT+, but not after applying rTMS over the control region (inferior temporal gyrus). The decrease in performance caused by applying rTMS to MT+ suggests that MT+ is a causally responsible region for apparent motion perception, and thus, further supports the idea that MT+ plays a major role in the perception of motion.

  11. International Reports on Literacy Research: France and Argentina

    ERIC Educational Resources Information Center

    Malloy, Jacquelynn A., Comp.; Botzakis, Stergios, Comp.

    2006-01-01

    This is a compilation of two separate reports on international literacy research from France and Argentina. In the reports from France, research correspondent Jacques Fijalkow detailed three research projects that included the following: (1) A description of adult literacy skills; (2) An investigation of how study-abroad students were integrated…

  12. In Wake of Riots, France Refashions Priority Zones

    ERIC Educational Resources Information Center

    Hendrie, Caroline

    2006-01-01

    This article deals with an initiative embarked upon by the government of France one year after widespread youth violence broke out in many disadvantaged communities in France. The initiative is aimed at adapting its 25-year-old "priority education" program to a landscape that has dramatically changed. The initiative is the centerpiece of…

  13. 78 FR 49116 - Airworthiness Directives; Eurocopter France Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ...-018-AD; Amendment 39-16847; AD 2011-22-05] RIN 2120-AA64 Airworthiness Directives; Eurocopter France... applies to certain Eurocopter France (Eurocopter) Model AS350B, B1, B2, B3, BA, C, D, and D1...

  14. Influenza D Virus in Cattle, France, 2011–2014

    PubMed Central

    Pelletier, Claire; Meyer, Gilles

    2015-01-01

    A new influenza virus, genus D, isolated in US pigs and cattle, has also been circulating in cattle in France. It was first identified there in 2011, and an increase was detected in 2014. The virus genome in France is 94%–99% identical to its US counterpart, which suggests intercontinental spillover. PMID:25628038

  15. France: The Move toward Distance Education in the University Sector

    ERIC Educational Resources Information Center

    Mortimer, Peter

    2005-01-01

    France is one of the most modern countries in the world and is a leading force in Europe. A highly literate and well-educated society, France's education statistics for 2003 show 12.1 million French children in primary and secondary education and 2.2 million students in tertiary education. The concept of education as a market commodity--long since…

  16. A Primer for Accompanying Secondary Student Groups to France. [Revised].

    ERIC Educational Resources Information Center

    Becker, Jim

    Many of the factors that can help ensure a successful and positive learning experience for teachers, leaders, chaperons, and students who travel and/or study in France are addressed in this publication. Although it is geared toward France, many of the ideas, especially the section on pre-departure orientation, can be applied to any travel group.…

  17. France: The Challenges of Renewal. Headline Series #282.

    ERIC Educational Resources Information Center

    DePorte, A. W.

    France has responded well to the social, economic, and political challenges which began when that nation was defeated by Germany in 1940. Two major challenges have been to limit internal quarrels which reduce the nation's ability to handle current issues and to accept the fact that France is no longer the greatest power in Europe. Chapter 1…

  18. Social Representation of Gifted Children: A Preliminary Study in France

    ERIC Educational Resources Information Center

    Tavani, Jean Louis; Zenasni, Franck; Pereira-Fradin, Maria

    2009-01-01

    There is a growing recognition of giftedness in France and the need for identification. Social Representations (SR) of gifted children have never been examined in France with an appropriate methodology, yet it is important to do so as the information obtained may help ensure the insertion and inclusion of these children in school and society. The…

  19. The Challenges Facing Catholic Education in France Today

    ERIC Educational Resources Information Center

    Moog, François

    2016-01-01

    The effects of secularisation on society demand a rethinking of the identity and mission of Catholic schools in France. In 2013, the French bishops published a new directory which offers new approaches, described here, based on the three challenges facing Catholic education in France: linking social responsibility and evangelisation, setting up…

  20. France: The Move toward Distance Education in the University Sector

    ERIC Educational Resources Information Center

    Mortimer, Peter

    2005-01-01

    France is one of the most modern countries in the world and is a leading force in Europe. A highly literate and well-educated society, France's education statistics for 2003 show 12.1 million French children in primary and secondary education and 2.2 million students in tertiary education. The concept of education as a market commodity--long since…